#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q96KP6 uniprotkb:Q8N1G4 intact:EBI-2509913|ensembl:ENSP00000057513|uniprotkb:Q9H780|uniprotkb:A8K2Z4|uniprotkb:A1A574|uniprotkb:Q96PQ3|uniprotkb:B4DVF5|uniprotkb:B4E023 intact:EBI-2509921|ensembl:ENSP00000367498|uniprotkb:Q9ULN5 psi-mi:tnip3_human(display_long)|uniprotkb:TNIP3(gene name)|psi-mi:TNIP3(display_short)|uniprotkb:ABIN3(gene name synonym)|uniprotkb:LIND(gene name synonym)|uniprotkb:Listeria-induced gene protein(gene name synonym)|uniprotkb:A20-binding inhibitor of NF-kappa-B activation 3(gene name synonym) psi-mi:lrc47_human(display_long)|uniprotkb:LRRC47(gene name)|psi-mi:LRRC47(display_short)|uniprotkb:KIAA1185(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2509899|imex:IM-12079-51 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005829"(cytosol)|go:"GO:0006954"(inflammatory response)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0071222"(cellular response to lipopolysaccharide)|interpro:IPR032419|interpro:IPR033574|ensembl:ENSG00000050730(gene)|ensembl:ENST00000057513(transcript)|go:"GO:0002756"(MyD88-independent toll-like receptor signaling pathway)|reactome:R-HSA-5689896|refseq:NP_079149.3|refseq:NP_001231693.1|refseq:NP_001122315.2 ensembl:ENSG00000130764(gene)|ensembl:ENST00000378251(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004826"(phenylalanine-tRNA ligase activity)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR005146(B3/B4 tRNA-binding domain)|interpro:IPR020825|interpro:IPR025875|interpro:IPR032675|rcsb pdb:6ZXD|rcsb pdb:6ZXE|rcsb pdb:6ZXF|rcsb pdb:6ZXG|refseq:NP_065761.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:5bgfpxYiGPdno4T5MyJmPCj1e0A9606 rogid:aPzU//EIwK8J4it97jCw/YyKFWU9606 intact-crc:9A7C4147C311BF9E|rigid:8plzhcwSiU+qvNi5HBNgrKtqQMk false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96KP6 uniprotkb:P28331 intact:EBI-2509913|ensembl:ENSP00000057513|uniprotkb:Q9H780|uniprotkb:A8K2Z4|uniprotkb:A1A574|uniprotkb:Q96PQ3|uniprotkb:B4DVF5|uniprotkb:B4E023 intact:EBI-1043922|uniprotkb:B4DPG1|uniprotkb:B4DUC1|uniprotkb:Q53TR8|uniprotkb:Q8N1C4|uniprotkb:Q8TCC9|ensembl:ENSP00000233190|ensembl:ENSP00000399912|ensembl:ENSP00000489640|ensembl:ENSP00000490898|uniprotkb:B4DJA0|uniprotkb:B4DIN9|uniprotkb:E7ENF3 psi-mi:tnip3_human(display_long)|uniprotkb:TNIP3(gene name)|psi-mi:TNIP3(display_short)|uniprotkb:ABIN3(gene name synonym)|uniprotkb:LIND(gene name synonym)|uniprotkb:Listeria-induced gene protein(gene name synonym)|uniprotkb:A20-binding inhibitor of NF-kappa-B activation 3(gene name synonym) psi-mi:ndus1_human(display_long)|uniprotkb:NDUFS1(gene name)|psi-mi:NDUFS1(display_short)|uniprotkb:Complex I-75kD(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2509899|imex:IM-12079-51 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005829"(cytosol)|go:"GO:0006954"(inflammatory response)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0071222"(cellular response to lipopolysaccharide)|interpro:IPR032419|interpro:IPR033574|ensembl:ENSG00000050730(gene)|ensembl:ENST00000057513(transcript)|go:"GO:0002756"(MyD88-independent toll-like receptor signaling pathway)|reactome:R-HSA-5689896|refseq:NP_079149.3|refseq:NP_001231693.1|refseq:NP_001122315.2 refseq:NP_001186913.1|refseq:NP_004997.4|ensembl:ENSG00000023228(gene)|ensembl:ENSG00000283447(gene)|ensembl:ENST00000233190(transcript)|ensembl:ENST00000449699(transcript)|ensembl:ENST00000635748(transcript)|ensembl:ENST00000636505(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0009055"(electron transfer activity)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0045333"(cellular respiration)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0072593"(reactive oxygen species metabolic process)|interpro:IPR000283(NADH dehydrogenase 75 kDa subunit, conserved site)|interpro:IPR001041(Ferredoxin)|interpro:IPR006656(Molybdopterin oxidoreductase)|interpro:IPR006963(Molybdopterin oxidoreductase Fe4S4 region)|interpro:IPR010228(NADH-quinone oxidoreductase, chain G)|interpro:IPR015405(NADH-quinone oxidoreductase, chain G, C-terminal)|interpro:IPR019574|interpro:IPR036010|mint:P28331|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198|go:"GO:0005758"(mitochondrial intermembrane space)|refseq:NP_001186911.1|refseq:NP_001186912.1|refseq:NP_001186910.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:5bgfpxYiGPdno4T5MyJmPCj1e0A9606 rogid:xznBU7fYzFPWvWbs2c/Q+8hV1Kw9606 intact-crc:9A7C4147C311BF9E|rigid:8plzhcwSiU+qvNi5HBNgrKtqQMk false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96KP6 uniprotkb:P30154 intact:EBI-2509913|ensembl:ENSP00000057513|uniprotkb:Q9H780|uniprotkb:A8K2Z4|uniprotkb:A1A574|uniprotkb:Q96PQ3|uniprotkb:B4DVF5|uniprotkb:B4E023 intact:EBI-357094|uniprotkb:O75620|uniprotkb:Q8NHV8|uniprotkb:B0YJ69|intact:EBI-2559603|uniprotkb:B4DWW5|uniprotkb:B4DGQ6|uniprotkb:F8W8G1|uniprotkb:A8MY67|uniprotkb:B4DK91|ensembl:ENSP00000437193 psi-mi:tnip3_human(display_long)|uniprotkb:TNIP3(gene name)|psi-mi:TNIP3(display_short)|uniprotkb:ABIN3(gene name synonym)|uniprotkb:LIND(gene name synonym)|uniprotkb:Listeria-induced gene protein(gene name synonym)|uniprotkb:A20-binding inhibitor of NF-kappa-B activation 3(gene name synonym) psi-mi:2aab_human(display_long)|uniprotkb:PPP2R1B(gene name)|psi-mi:PPP2R1B(display_short)|uniprotkb:PP2A subunit A isoform PR65-beta(gene name synonym)|uniprotkb:PP2A subunit A isoform R1-beta(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2509899|imex:IM-12079-51 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005829"(cytosol)|go:"GO:0006954"(inflammatory response)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0071222"(cellular response to lipopolysaccharide)|interpro:IPR032419|interpro:IPR033574|ensembl:ENSG00000050730(gene)|ensembl:ENST00000057513(transcript)|go:"GO:0002756"(MyD88-independent toll-like receptor signaling pathway)|reactome:R-HSA-5689896|refseq:NP_079149.3|refseq:NP_001231693.1|refseq:NP_001122315.2 dip:DIP-36616N|refseq:NP_001171033.1|refseq:NP_001171034.1|refseq:NP_002707.3|refseq:NP_859050.1|refseq:NP_859051.1|ensembl:ENST00000527614(transcript)|go:"GO:0000159"(protein phosphatase type 2A complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0045121"(membrane raft)|go:"GO:0060561"(apoptotic process involved in morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000357(HEAT)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR021133|mint:P30154|reactome:R-HSA-113501|reactome:R-HSA-141444|reactome:R-HSA-163685|reactome:R-HSA-163767|reactome:R-HSA-180024|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-198753|reactome:R-HSA-202670|reactome:R-HSA-2465910|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-389513|reactome:R-HSA-432142|reactome:R-HSA-4641262|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5467337|reactome:R-HSA-5467340|reactome:R-HSA-5467348|reactome:R-HSA-5663220|reactome:R-HSA-5673000|reactome:R-HSA-5675221|reactome:R-HSA-6804757|reactome:R-HSA-6811558|reactome:R-HSA-68877|reactome:R-HSA-69231|reactome:R-HSA-69273|reactome:R-HSA-9634600|reactome:R-HSA-9648025|ensembl:ENSG00000137713(gene) psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:5bgfpxYiGPdno4T5MyJmPCj1e0A9606 rogid:fYgJ5+zyhLkZTUHV535I4LB+4iw9606 intact-crc:9A7C4147C311BF9E|rigid:8plzhcwSiU+qvNi5HBNgrKtqQMk false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96KP6 uniprotkb:Q04917 intact:EBI-2509913|ensembl:ENSP00000057513|uniprotkb:Q9H780|uniprotkb:A8K2Z4|uniprotkb:A1A574|uniprotkb:Q96PQ3|uniprotkb:B4DVF5|uniprotkb:B4E023 intact:EBI-306940|ensembl:ENSP00000248975|intact:EBI-11759595 psi-mi:tnip3_human(display_long)|uniprotkb:TNIP3(gene name)|psi-mi:TNIP3(display_short)|uniprotkb:ABIN3(gene name synonym)|uniprotkb:LIND(gene name synonym)|uniprotkb:Listeria-induced gene protein(gene name synonym)|uniprotkb:A20-binding inhibitor of NF-kappa-B activation 3(gene name synonym) psi-mi:1433f_human(display_long)|uniprotkb:YWHAH(gene name)|psi-mi:YWHAH(display_short)|uniprotkb:YWHA1(gene name synonym)|uniprotkb:Protein AS1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2509899|imex:IM-12079-51 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005829"(cytosol)|go:"GO:0006954"(inflammatory response)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0071222"(cellular response to lipopolysaccharide)|interpro:IPR032419|interpro:IPR033574|ensembl:ENSG00000050730(gene)|ensembl:ENST00000057513(transcript)|go:"GO:0002756"(MyD88-independent toll-like receptor signaling pathway)|reactome:R-HSA-5689896|refseq:NP_079149.3|refseq:NP_001231693.1|refseq:NP_001122315.2 go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0050774"(negative regulation of dendrite morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0086010"(membrane depolarization during action potential)|go:"GO:2000649"(regulation of sodium ion transmembrane transporter activity)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:Q04917|rcsb pdb:2C63|rcsb pdb:2C74|reactome:R-HSA-111447|reactome:R-HSA-1445148|reactome:R-HSA-5625740|reactome:R-HSA-5628897|reactome:R-HSA-75035|ensembl:ENSG00000128245(gene)|ensembl:ENST00000248975(transcript)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0003779"(actin binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006713"(glucocorticoid catabolic process)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0014704"(intercalated disc)|go:"GO:0017080"(sodium channel regulator activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021762"(substantia nigra development)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042921"(glucocorticoid receptor signaling pathway)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|refseq:NP_003396.1|dip:DIP-27566N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:5bgfpxYiGPdno4T5MyJmPCj1e0A9606 rogid:VhFYPSsW3IRC388FTlmwwN37HnU9606 intact-crc:9A7C4147C311BF9E|rigid:8plzhcwSiU+qvNi5HBNgrKtqQMk false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96KP6 uniprotkb:Q5H9R7 intact:EBI-2509913|ensembl:ENSP00000057513|uniprotkb:Q9H780|uniprotkb:A8K2Z4|uniprotkb:A1A574|uniprotkb:Q96PQ3|uniprotkb:B4DVF5|uniprotkb:B4E023 intact:EBI-355498|uniprotkb:Q3B7I1|uniprotkb:Q7L4R8|uniprotkb:Q8N3B2|uniprotkb:Q96MB2|uniprotkb:Q9H2K5|uniprotkb:Q9H2K6|uniprotkb:Q9HCL4|uniprotkb:Q9NUY3|uniprotkb:Q3I4Y0|uniprotkb:Q3KR35|uniprotkb:Q68CR3|intact:EBI-28971860|ensembl:ENSP00000377389 psi-mi:tnip3_human(display_long)|uniprotkb:TNIP3(gene name)|psi-mi:TNIP3(display_short)|uniprotkb:ABIN3(gene name synonym)|uniprotkb:LIND(gene name synonym)|uniprotkb:Listeria-induced gene protein(gene name synonym)|uniprotkb:A20-binding inhibitor of NF-kappa-B activation 3(gene name synonym) psi-mi:pp6r3_human(display_long)|uniprotkb:PPP6R3(gene name)|psi-mi:PPP6R3(display_short)|uniprotkb:C11orf23(gene name synonym)|uniprotkb:KIAA1558(gene name synonym)|uniprotkb:PP6R3(gene name synonym)|uniprotkb:SAPL(gene name synonym)|uniprotkb:Sporulation-induced transcript 4-associated protein SAPL(gene name synonym)|uniprotkb:SAPS domain family member 3(gene name synonym)|uniprotkb:SAPS3(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2509899|imex:IM-12079-51 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005829"(cytosol)|go:"GO:0006954"(inflammatory response)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0071222"(cellular response to lipopolysaccharide)|interpro:IPR032419|interpro:IPR033574|ensembl:ENSG00000050730(gene)|ensembl:ENST00000057513(transcript)|go:"GO:0002756"(MyD88-independent toll-like receptor signaling pathway)|reactome:R-HSA-5689896|refseq:NP_079149.3|refseq:NP_001231693.1|refseq:NP_001122315.2 refseq:NP_001157632.1|refseq:NP_001157633.1|refseq:NP_001157634.1|refseq:NP_001157635.1|refseq:NP_001157636.1|refseq:NP_060782.2|ensembl:ENST00000265636|ensembl:ENSP00000265636|ensembl:ENSP00000377389|ensembl:ENST00000393801|ensembl:ENSP00000377390|ensembl:ENST00000524845|ensembl:ENSP00000431415|ensembl:ENST00000524904|ensembl:ENSP00000433058|ensembl:ENST00000529710|ensembl:ENSP00000437329|refseq:XP_011543442.1|refseq:XP_006718676.1|refseq:XP_006718677.1|refseq:XP_006718681.1|refseq:XP_006718687.1|refseq:XP_016873451.1|refseq:XP_016873452.1|refseq:XP_016873455.1|ensembl:ENSG00000110075(gene)|ensembl:ENST00000393800(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|interpro:IPR007587(SIT4 phosphatase-associated protein)|interpro:IPR016024(Armadillo-type fold)|mint:Q5H9R7|reactome:R-HSA-171319|reactome:R-HSA-204005 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:5bgfpxYiGPdno4T5MyJmPCj1e0A9606 rogid:9hU14AmzYI9nORfchfMtLoyRecA9606 intact-crc:9A7C4147C311BF9E|rigid:8plzhcwSiU+qvNi5HBNgrKtqQMk false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96KP6 uniprotkb:Q14566 intact:EBI-2509913|ensembl:ENSP00000057513|uniprotkb:Q9H780|uniprotkb:A8K2Z4|uniprotkb:A1A574|uniprotkb:Q96PQ3|uniprotkb:B4DVF5|uniprotkb:B4E023 intact:EBI-374900|uniprotkb:Q13504|uniprotkb:Q99859|uniprotkb:B2R6H2|ensembl:ENSP00000264156 psi-mi:tnip3_human(display_long)|uniprotkb:TNIP3(gene name)|psi-mi:TNIP3(display_short)|uniprotkb:ABIN3(gene name synonym)|uniprotkb:LIND(gene name synonym)|uniprotkb:Listeria-induced gene protein(gene name synonym)|uniprotkb:A20-binding inhibitor of NF-kappa-B activation 3(gene name synonym) psi-mi:mcm6_human(display_long)|uniprotkb:MCM6(gene name)|psi-mi:MCM6(display_short)|uniprotkb:p105MCM(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2509899|imex:IM-12079-51 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005829"(cytosol)|go:"GO:0006954"(inflammatory response)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0071222"(cellular response to lipopolysaccharide)|interpro:IPR032419|interpro:IPR033574|ensembl:ENSG00000050730(gene)|ensembl:ENST00000057513(transcript)|go:"GO:0002756"(MyD88-independent toll-like receptor signaling pathway)|reactome:R-HSA-5689896|refseq:NP_079149.3|refseq:NP_001231693.1|refseq:NP_001122315.2 ensembl:ENST00000264156(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0042555"(MCM complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0071162"(CMG complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902969"(mitotic DNA replication)|ensembl:ENSG00000076003(gene)|reactome:R-HSA-68962|reactome:R-HSA-69052|interpro:IPR008049(MCM protein 6)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR018525|interpro:IPR027417|interpro:IPR027925|interpro:IPR031327|interpro:IPR033762|interpro:IPR041024|interpro:IPR041562|interpro:IPR001208(MCM)|mint:Q14566|rcsb pdb:2KLQ|rcsb pdb:2LE8|rcsb pdb:6XTX|rcsb pdb:6XTY|reactome:R-HSA-176187|reactome:R-HSA-176974|reactome:R-HSA-68867|reactome:R-HSA-68949|refseq:NP_005906.2|dip:DIP-31727N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:5bgfpxYiGPdno4T5MyJmPCj1e0A9606 rogid:gVpEwgfSwwxvP2T2CvCzIukthY49606 intact-crc:9A7C4147C311BF9E|rigid:8plzhcwSiU+qvNi5HBNgrKtqQMk false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96KP6 uniprotkb:P49189 intact:EBI-2509913|ensembl:ENSP00000057513|uniprotkb:Q9H780|uniprotkb:A8K2Z4|uniprotkb:A1A574|uniprotkb:Q96PQ3|uniprotkb:B4DVF5|uniprotkb:B4E023 intact:EBI-1055313|uniprotkb:B2R6X1|uniprotkb:Q6LCL1|uniprotkb:Q9NZT7|uniprotkb:Q5VV90|uniprotkb:B4DXY7|uniprotkb:B9EKV4 psi-mi:tnip3_human(display_long)|uniprotkb:TNIP3(gene name)|psi-mi:TNIP3(display_short)|uniprotkb:ABIN3(gene name synonym)|uniprotkb:LIND(gene name synonym)|uniprotkb:Listeria-induced gene protein(gene name synonym)|uniprotkb:A20-binding inhibitor of NF-kappa-B activation 3(gene name synonym) psi-mi:al9a1_human(display_long)|uniprotkb:Aldehyde dehydrogenase family 9 member A1(gene name synonym)|uniprotkb:Aldehyde dehydrogenase E3 isozyme(gene name synonym)|uniprotkb:Gamma-aminobutyraldehyde dehydrogenase(gene name synonym)|uniprotkb:R-aminobutyraldehyde dehydrogenase(gene name synonym)|uniprotkb:ALDH9A1(gene name)|psi-mi:ALDH9A1(display_short)|uniprotkb:ALDH7(gene name synonym)|uniprotkb:ALDH9(gene name synonym)|uniprotkb:ALDH4(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2509899|imex:IM-12079-51 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005829"(cytosol)|go:"GO:0006954"(inflammatory response)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0071222"(cellular response to lipopolysaccharide)|interpro:IPR032419|interpro:IPR033574|ensembl:ENSG00000050730(gene)|ensembl:ENST00000057513(transcript)|go:"GO:0002756"(MyD88-independent toll-like receptor signaling pathway)|reactome:R-HSA-5689896|refseq:NP_079149.3|refseq:NP_001231693.1|refseq:NP_001122315.2 refseq:NP_000687.3|interpro:IPR016161(Aldehyde/histidinol dehydrogenase)|interpro:IPR016160(Aldehyde dehydrogenase, conserved site)|interpro:IPR016162(Aldehyde dehydrogenase, N-terminal)|interpro:IPR015590(Aldehyde dehydrogenase)|refseq:XP_011507596.1|interpro:IPR029510|go:"GO:0004029"("aldehyde dehydrogenase (NAD+) activity")|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006081"(cellular aldehyde metabolic process)|go:"GO:0019145"(aminobutyraldehyde dehydrogenase activity)|go:"GO:0033737"(1-pyrroline dehydrogenase activity)|go:"GO:0042136"(neurotransmitter biosynthetic process)|go:"GO:0042445"(hormone metabolic process)|go:"GO:0043878"("glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity")|go:"GO:0045329"(carnitine biosynthetic process)|go:"GO:0047105"(4-trimethylammoniobutyraldehyde dehydrogenase activity)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0070062"(extracellular exosome)|rcsb pdb:6QAK|rcsb pdb:6QAO|rcsb pdb:6QAP|rcsb pdb:6VR6|rcsb pdb:6VWF|reactome:R-HSA-71262|interpro:IPR016163(Aldehyde dehydrogenase, C-terminal)|mint:P49189 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:5bgfpxYiGPdno4T5MyJmPCj1e0A9606 rogid:MYde00UETppWGSEKa35Jsck7Joc9606 intact-crc:9A7C4147C311BF9E|rigid:8plzhcwSiU+qvNi5HBNgrKtqQMk false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96KP6 uniprotkb:P23378 intact:EBI-2509913|ensembl:ENSP00000057513|uniprotkb:Q9H780|uniprotkb:A8K2Z4|uniprotkb:A1A574|uniprotkb:Q96PQ3|uniprotkb:B4DVF5|uniprotkb:B4E023 intact:EBI-2509907|ensembl:ENSP00000370737|uniprotkb:Q2M2F8 psi-mi:tnip3_human(display_long)|uniprotkb:TNIP3(gene name)|psi-mi:TNIP3(display_short)|uniprotkb:ABIN3(gene name synonym)|uniprotkb:LIND(gene name synonym)|uniprotkb:Listeria-induced gene protein(gene name synonym)|uniprotkb:A20-binding inhibitor of NF-kappa-B activation 3(gene name synonym) psi-mi:gcsp_human(display_long)|uniprotkb:GLDC(gene name)|psi-mi:GLDC(display_short)|uniprotkb:GCSP(gene name synonym)|uniprotkb:Glycine decarboxylase(gene name synonym)|uniprotkb:Glycine cleavage system P protein(gene name synonym)|uniprotkb:"Glycine dehydrogenase (aminomethyl-transferring)"(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2509899|imex:IM-12079-51 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005829"(cytosol)|go:"GO:0006954"(inflammatory response)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0071222"(cellular response to lipopolysaccharide)|interpro:IPR032419|interpro:IPR033574|ensembl:ENSG00000050730(gene)|ensembl:ENST00000057513(transcript)|go:"GO:0002756"(MyD88-independent toll-like receptor signaling pathway)|reactome:R-HSA-5689896|refseq:NP_079149.3|refseq:NP_001231693.1|refseq:NP_001122315.2 ensembl:ENSG00000178445(gene)|ensembl:ENST00000321612(transcript)|go:"GO:0004375"("glycine dehydrogenase (decarboxylating) activity")|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005886"(plasma membrane)|go:"GO:0005960"(glycine cleavage complex)|go:"GO:0006546"(glycine catabolic process)|go:"GO:0009055"(electron transfer activity)|go:"GO:0016594"(glycine binding)|go:"GO:0016829"(lyase activity)|go:"GO:0019464"(glycine decarboxylation via glycine cleavage system)|go:"GO:0019899"(enzyme binding)|go:"GO:0030170"(pyridoxal phosphate binding)|go:"GO:0036255"(response to methylamine)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070280"(pyridoxal binding)|go:"GO:1903442"(response to lipoic acid)|interpro:IPR001597(Aromatic amino acid beta-eliminating lyase/threonine aldolase)|interpro:IPR003437(Glycine cleavage system P-protein)|interpro:IPR015421(Pyridoxal phosphate-dependent transferase, major region, subdomain 1)|interpro:IPR015422(Pyridoxal phosphate-dependent transferase, major region, subdomain 2)|interpro:IPR015424(Pyridoxal phosphate-dependent transferase, major region)|interpro:IPR020581|rcsb pdb:6I33|rcsb pdb:6I34|rcsb pdb:6I35|reactome:R-HSA-6783984|refseq:NP_000161.2 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:5bgfpxYiGPdno4T5MyJmPCj1e0A9606 rogid:zNBF42twnLftxt9dEQsTcGD5dts9606 intact-crc:9A7C4147C311BF9E|rigid:8plzhcwSiU+qvNi5HBNgrKtqQMk false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96KP6 uniprotkb:Q8WXI2 intact:EBI-2509913|ensembl:ENSP00000057513|uniprotkb:Q9H780|uniprotkb:A8K2Z4|uniprotkb:A1A574|uniprotkb:Q96PQ3|uniprotkb:B4DVF5|uniprotkb:B4E023 intact:EBI-1045119|uniprotkb:O94976|uniprotkb:Q5JPK4|uniprotkb:Q8WXI1|uniprotkb:B9EG83|uniprotkb:Q5JPN0|ensembl:ENSP00000368824|uniprotkb:B4DGR4|uniprotkb:B7ZLJ1|uniprotkb:E7ESA4 psi-mi:tnip3_human(display_long)|uniprotkb:TNIP3(gene name)|psi-mi:TNIP3(display_short)|uniprotkb:ABIN3(gene name synonym)|uniprotkb:LIND(gene name synonym)|uniprotkb:Listeria-induced gene protein(gene name synonym)|uniprotkb:A20-binding inhibitor of NF-kappa-B activation 3(gene name synonym) psi-mi:cnkr2_human(display_long)|uniprotkb:CNKSR2(gene name)|psi-mi:CNKSR2(display_short)|uniprotkb:CNK2(gene name synonym)|uniprotkb:KIAA0902(gene name synonym)|uniprotkb:KSR2(gene name synonym)|uniprotkb:CNK homolog protein 2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2509899|imex:IM-12079-51 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005829"(cytosol)|go:"GO:0006954"(inflammatory response)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0071222"(cellular response to lipopolysaccharide)|interpro:IPR032419|interpro:IPR033574|ensembl:ENSG00000050730(gene)|ensembl:ENST00000057513(transcript)|go:"GO:0002756"(MyD88-independent toll-like receptor signaling pathway)|reactome:R-HSA-5689896|refseq:NP_079149.3|refseq:NP_001231693.1|refseq:NP_001122315.2 refseq:NP_001162119.1|refseq:NP_055742.2|refseq:NP_001162118.1|refseq:NP_001162120.1|ensembl:ENSG00000149970(gene)|ensembl:ENST00000379510(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0019901"(protein kinase binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099147"(extrinsic component of postsynaptic density membrane)|go:"GO:0099173"(postsynapse organization)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR010599(Connector enhancer of kinase suppressor of ras 2)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR017874|interpro:IPR036034|rcsb pdb:2EAN|rcsb pdb:3BS5|reactome:R-HSA-5674135|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-9649948|reactome:R-HSA-9656223|ensembl:ENSP00000368824|ensembl:ENST00000425654|ensembl:ENSP00000397906|ensembl:ENST00000543067|ensembl:ENSP00000444633|ensembl:ENST00000642359|ensembl:ENSP00000496709|dip:DIP-29736N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:5bgfpxYiGPdno4T5MyJmPCj1e0A9606 rogid:FEIgggNg8LMikG2NZ6LHRD3lKDw9606 intact-crc:9A7C4147C311BF9E|rigid:8plzhcwSiU+qvNi5HBNgrKtqQMk false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96KP6 uniprotkb:Q9UHD2 intact:EBI-2509913|ensembl:ENSP00000057513|uniprotkb:Q9H780|uniprotkb:A8K2Z4|uniprotkb:A1A574|uniprotkb:Q96PQ3|uniprotkb:B4DVF5|uniprotkb:B4E023 intact:EBI-356402|intact:EBI-5773956|intact:EBI-1383470|uniprotkb:Q8IYV3|uniprotkb:Q9NUJ5|ensembl:ENSP00000329967|ensembl:ENSP00000498995|uniprotkb:A8K4S4 psi-mi:tnip3_human(display_long)|uniprotkb:TNIP3(gene name)|psi-mi:TNIP3(display_short)|uniprotkb:ABIN3(gene name synonym)|uniprotkb:LIND(gene name synonym)|uniprotkb:Listeria-induced gene protein(gene name synonym)|uniprotkb:A20-binding inhibitor of NF-kappa-B activation 3(gene name synonym) psi-mi:tbk1_human(display_long)|uniprotkb:TBK1(gene name)|psi-mi:TBK1(display_short)|uniprotkb:NAK(gene name synonym)|uniprotkb:TANK-binding kinase 1(gene name synonym)|uniprotkb:T2K(gene name synonym)|uniprotkb:NF-kappa-B-activating kinase(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2509899|imex:IM-12079-51 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005829"(cytosol)|go:"GO:0006954"(inflammatory response)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0071222"(cellular response to lipopolysaccharide)|interpro:IPR032419|interpro:IPR033574|ensembl:ENSG00000050730(gene)|ensembl:ENST00000057513(transcript)|go:"GO:0002756"(MyD88-independent toll-like receptor signaling pathway)|reactome:R-HSA-5689896|refseq:NP_079149.3|refseq:NP_001231693.1|refseq:NP_001122315.2 refseq:NP_037386.1|go:"GO:0004672"(protein kinase activity)|ensembl:ENSG00000183735(gene)|ensembl:ENST00000331710(transcript)|ensembl:ENST00000650790(transcript)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0032479"(regulation of type I interferon production)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044565"(dendritic cell proliferation)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0060340"(positive regulation of type I interferon-mediated signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901214"(regulation of neuron death)|go:"GO:1904417"(positive regulation of xenophagy)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR041087|interpro:IPR041309|mint:Q9UHD2|rcsb pdb:4EFO|rcsb pdb:4EUT|rcsb pdb:4EUU|rcsb pdb:4IM0|rcsb pdb:4IM2|rcsb pdb:4IM3|rcsb pdb:4IW0|rcsb pdb:4IWO|rcsb pdb:4IWP|rcsb pdb:4IWQ|rcsb pdb:5EOA|rcsb pdb:5EOF|rcsb pdb:5EP6|rcsb pdb:5W5V|rcsb pdb:6BNY|rcsb pdb:6BOD|rcsb pdb:6BOE|rcsb pdb:6CQ0|rcsb pdb:6CQ4|rcsb pdb:6CQ5|rcsb pdb:6NT9|rcsb pdb:6O8B|rcsb pdb:6RSR|rcsb pdb:6RST|rcsb pdb:6RSU|reactome:R-HSA-1606341|reactome:R-HSA-168928|reactome:R-HSA-3134975|reactome:R-HSA-3249367|reactome:R-HSA-3270619|reactome:R-HSA-9008059|reactome:R-HSA-9013973|reactome:R-HSA-918233|reactome:R-HSA-933541|reactome:R-HSA-936440|reactome:R-HSA-936964|reactome:R-HSA-9679191|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0009615"(response to virus)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019903"(protein phosphatase binding)|refseq:XP_005268866.1|refseq:XP_005268867.1|dip:DIP-27529N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:5bgfpxYiGPdno4T5MyJmPCj1e0A9606 rogid:Cf+RbPJBZTpm7XIqbAD2OEC6VEs9606 intact-crc:9A7C4147C311BF9E|rigid:8plzhcwSiU+qvNi5HBNgrKtqQMk false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96KP6 uniprotkb:Q9UK99 intact:EBI-2509913|ensembl:ENSP00000057513|uniprotkb:Q9H780|uniprotkb:A8K2Z4|uniprotkb:A1A574|uniprotkb:Q96PQ3|uniprotkb:B4DVF5|uniprotkb:B4E023 intact:EBI-2509901|uniprotkb:B3KY16|uniprotkb:D3DR05|uniprotkb:Q9H0V2|uniprotkb:Q86X90|uniprotkb:Q9NUX2|ensembl:ENSP00000265651 psi-mi:tnip3_human(display_long)|uniprotkb:TNIP3(gene name)|psi-mi:TNIP3(display_short)|uniprotkb:ABIN3(gene name synonym)|uniprotkb:LIND(gene name synonym)|uniprotkb:Listeria-induced gene protein(gene name synonym)|uniprotkb:A20-binding inhibitor of NF-kappa-B activation 3(gene name synonym) psi-mi:fbx3_human(display_long)|uniprotkb:FBXO3(gene name)|psi-mi:FBXO3(display_short)|uniprotkb:FBX3(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2509899|imex:IM-12079-51 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005829"(cytosol)|go:"GO:0006954"(inflammatory response)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0071222"(cellular response to lipopolysaccharide)|interpro:IPR032419|interpro:IPR033574|ensembl:ENSG00000050730(gene)|ensembl:ENST00000057513(transcript)|go:"GO:0002756"(MyD88-independent toll-like receptor signaling pathway)|reactome:R-HSA-5689896|refseq:NP_079149.3|refseq:NP_001231693.1|refseq:NP_001122315.2 refseq:NP_036307.2|refseq:NP_208385.1|dip:DIP-53688N|ensembl:ENSG00000110429(gene)|ensembl:ENST00000265651(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR007474(ApaG)|interpro:IPR018958|interpro:IPR028388|interpro:IPR036047|interpro:IPR036767|interpro:IPR037883|rcsb pdb:5HDW psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:5bgfpxYiGPdno4T5MyJmPCj1e0A9606 rogid:zQB8ig3s51tXN81NtMrou84Rv6I9606 intact-crc:9A7C4147C311BF9E|rigid:8plzhcwSiU+qvNi5HBNgrKtqQMk false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96KP6 uniprotkb:P31946 intact:EBI-2509913|ensembl:ENSP00000057513|uniprotkb:Q9H780|uniprotkb:A8K2Z4|uniprotkb:A1A574|uniprotkb:Q96PQ3|uniprotkb:B4DVF5|uniprotkb:B4E023 intact:EBI-359815|uniprotkb:A8K9K2|uniprotkb:E1P616|ensembl:ENSP00000300161|ensembl:ENSP00000361930 psi-mi:tnip3_human(display_long)|uniprotkb:TNIP3(gene name)|psi-mi:TNIP3(display_short)|uniprotkb:ABIN3(gene name synonym)|uniprotkb:LIND(gene name synonym)|uniprotkb:Listeria-induced gene protein(gene name synonym)|uniprotkb:A20-binding inhibitor of NF-kappa-B activation 3(gene name synonym) psi-mi:1433b_human(display_long)|uniprotkb:YWHAB(gene name)|psi-mi:YWHAB(display_short)|uniprotkb:Protein kinase C inhibitor protein 1(gene name synonym)|uniprotkb:Protein 1054(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2509899|imex:IM-12079-51 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005829"(cytosol)|go:"GO:0006954"(inflammatory response)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0071222"(cellular response to lipopolysaccharide)|interpro:IPR032419|interpro:IPR033574|ensembl:ENSG00000050730(gene)|ensembl:ENST00000057513(transcript)|go:"GO:0002756"(MyD88-independent toll-like receptor signaling pathway)|reactome:R-HSA-5689896|refseq:NP_079149.3|refseq:NP_001231693.1|refseq:NP_001122315.2 refseq:NP_003395.1|refseq:NP_647539.1|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051220"(cytoplasmic sequestering of protein)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:P31946|rcsb pdb:2BQ0|rcsb pdb:2C23|rcsb pdb:4DNK|rcsb pdb:5N10|rcsb pdb:6A5Q|rcsb pdb:6BYK|rcsb pdb:6GN0|rcsb pdb:6GN8|rcsb pdb:6GNJ|rcsb pdb:6GNK|rcsb pdb:6GNN|rcsb pdb:6HEP|reactome:R-HSA-111447|reactome:R-HSA-1445148|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-170968|reactome:R-HSA-170984|reactome:R-HSA-2028269|reactome:R-HSA-392517|reactome:R-HSA-450385|reactome:R-HSA-450513|reactome:R-HSA-5625740|reactome:R-HSA-5628897|reactome:R-HSA-5673000|reactome:R-HSA-5674135|reactome:R-HSA-5675221|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-75035|reactome:R-HSA-9614399|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9660537|ensembl:ENSG00000166913(gene)|ensembl:ENST00000353703(transcript)|ensembl:ENST00000372839(transcript)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005774"(vacuolar membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006605"(protein targeting)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0016020"(membrane)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|refseq:XP_016883528.1|dip:DIP-743N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:5bgfpxYiGPdno4T5MyJmPCj1e0A9606 rogid:rp43CodPzsPadWEPtbnpKFAVIIU9606 intact-crc:9A7C4147C311BF9E|rigid:8plzhcwSiU+qvNi5HBNgrKtqQMk false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96KP6 uniprotkb:P13489 intact:EBI-2509913|ensembl:ENSP00000057513|uniprotkb:Q9H780|uniprotkb:A8K2Z4|uniprotkb:A1A574|uniprotkb:Q96PQ3|uniprotkb:B4DVF5|uniprotkb:B4E023 intact:EBI-1237106|uniprotkb:Q8IZK8|uniprotkb:Q96FD7|uniprotkb:Q9BQ80|uniprotkb:Q9UDK6|ensembl:ENSP00000346402|ensembl:ENSP00000348515|ensembl:ENSP00000380729|ensembl:ENSP00000380738|ensembl:ENSP00000380739|ensembl:ENSP00000416589|ensembl:ENSP00000433999|ensembl:ENSP00000435594|ensembl:ENSP00000478664|ensembl:ENSP00000479004|ensembl:ENSP00000479966|ensembl:ENSP00000480036|ensembl:ENSP00000484572|ensembl:ENSP00000487753|ensembl:ENSP00000487940|ensembl:ENSP00000488734 psi-mi:tnip3_human(display_long)|uniprotkb:TNIP3(gene name)|psi-mi:TNIP3(display_short)|uniprotkb:ABIN3(gene name synonym)|uniprotkb:LIND(gene name synonym)|uniprotkb:Listeria-induced gene protein(gene name synonym)|uniprotkb:A20-binding inhibitor of NF-kappa-B activation 3(gene name synonym) psi-mi:rini_human(display_long)|uniprotkb:RNH1(gene name)|psi-mi:RNH1(display_short)|uniprotkb:PRI(gene name synonym)|uniprotkb:RNH(gene name synonym)|uniprotkb:Ribonuclease/angiogenin inhibitor 1(gene name synonym)|uniprotkb:Placental ribonuclease inhibitor(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2509899|imex:IM-12079-51 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005829"(cytosol)|go:"GO:0006954"(inflammatory response)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0071222"(cellular response to lipopolysaccharide)|interpro:IPR032419|interpro:IPR033574|ensembl:ENSG00000050730(gene)|ensembl:ENST00000057513(transcript)|go:"GO:0002756"(MyD88-independent toll-like receptor signaling pathway)|reactome:R-HSA-5689896|refseq:NP_079149.3|refseq:NP_001231693.1|refseq:NP_001122315.2 refseq:NP_002930.2|refseq:NP_976317.1|refseq:NP_976318.1|refseq:NP_976319.1|refseq:NP_976320.1|refseq:NP_976321.1|refseq:NP_976322.1|refseq:NP_976323.1|refseq:XP_011518557.1|refseq:XP_011518559.1|refseq:XP_011518560.1|refseq:XP_011518561.1|refseq:XP_011518562.1|refseq:XP_011518563.1|refseq:XP_011518564.1|refseq:XP_011518565.1|refseq:XP_016873595.1|ensembl:ENST00000619599(transcript)|ensembl:ENST00000621211(transcript)|ensembl:ENST00000632527(transcript)|ensembl:ENST00000632954(transcript)|ensembl:ENST00000633287(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006402"(mRNA catabolic process)|go:"GO:0008428"(ribonuclease inhibitor activity)|go:"GO:0032311"(angiogenin-PRI complex)|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR006553(Leucine-rich repeat, cysteine-containing subtype)|interpro:IPR032675|interpro:IPR041302|mint:P13489|rcsb pdb:1A4Y|rcsb pdb:1Z7X|rcsb pdb:2BEX|rcsb pdb:2Q4G|ensembl:ENSG00000023191(gene)|ensembl:ENSG00000276230(gene)|ensembl:ENST00000354420(transcript)|ensembl:ENST00000356187(transcript)|ensembl:ENST00000397604(transcript)|ensembl:ENST00000397614(transcript)|ensembl:ENST00000397615(transcript)|ensembl:ENST00000438658(transcript)|ensembl:ENST00000533410(transcript)|ensembl:ENST00000534797(transcript)|ensembl:ENST00000612988(transcript)|ensembl:ENST00000617351(transcript)|ensembl:ENST00000618184(transcript) psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:5bgfpxYiGPdno4T5MyJmPCj1e0A9606 rogid:1WMWoYulk8Aj8HYhDcqnauddUFk9606 intact-crc:9A7C4147C311BF9E|rigid:8plzhcwSiU+qvNi5HBNgrKtqQMk false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96KP6 uniprotkb:P52732 intact:EBI-2509913|ensembl:ENSP00000057513|uniprotkb:Q9H780|uniprotkb:A8K2Z4|uniprotkb:A1A574|uniprotkb:Q96PQ3|uniprotkb:B4DVF5|uniprotkb:B4E023 intact:EBI-355697|uniprotkb:A0AV49|uniprotkb:Q15716|uniprotkb:Q5VWX0|uniprotkb:B2RMV3|ensembl:ENSP00000260731 psi-mi:tnip3_human(display_long)|uniprotkb:TNIP3(gene name)|psi-mi:TNIP3(display_short)|uniprotkb:ABIN3(gene name synonym)|uniprotkb:LIND(gene name synonym)|uniprotkb:Listeria-induced gene protein(gene name synonym)|uniprotkb:A20-binding inhibitor of NF-kappa-B activation 3(gene name synonym) psi-mi:kif11_human(display_long)|uniprotkb:KIF11(gene name)|psi-mi:KIF11(display_short)|uniprotkb:EG5(gene name synonym)|uniprotkb:KNSL1(gene name synonym)|uniprotkb:TRIP5(gene name synonym)|uniprotkb:Kinesin-related motor protein Eg5(gene name synonym)|uniprotkb:Kinesin-like spindle protein HKSP(gene name synonym)|uniprotkb:Thyroid receptor-interacting protein 5(gene name synonym)|uniprotkb:Kinesin-like protein 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2509899|imex:IM-12079-51 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005829"(cytosol)|go:"GO:0006954"(inflammatory response)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0071222"(cellular response to lipopolysaccharide)|interpro:IPR032419|interpro:IPR033574|ensembl:ENSG00000050730(gene)|ensembl:ENST00000057513(transcript)|go:"GO:0002756"(MyD88-independent toll-like receptor signaling pathway)|reactome:R-HSA-5689896|refseq:NP_079149.3|refseq:NP_001231693.1|refseq:NP_001122315.2 refseq:NP_004514.2|ensembl:ENSG00000138160(gene)|ensembl:ENST00000260731(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000922"(spindle pole)|go:"GO:0003777"(microtubule motor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|rcsb pdb:1X88|rcsb pdb:1YRS|rcsb pdb:2FKY|rcsb pdb:2FL2|go:"GO:0007018"(microtubule-based movement)|go:"GO:0007051"(spindle organization)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007100"(mitotic centrosome separation)|go:"GO:0008017"(microtubule binding)|go:"GO:0008574"(plus-end-directed microtubule motor activity)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0046602"(regulation of mitotic centrosome separation)|go:"GO:0051301"(cell division)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090307"(mitotic spindle assembly)|interpro:IPR001752(Kinesin, motor region)|interpro:IPR019821|interpro:IPR025901|interpro:IPR027417|interpro:IPR036961|rcsb pdb:1II6|rcsb pdb:1Q0B|rcsb pdb:2FL6|rcsb pdb:2FME|rcsb pdb:2G1Q|rcsb pdb:2GM1|rcsb pdb:2IEH|rcsb pdb:2PG2|rcsb pdb:2Q2Y|rcsb pdb:2Q2Z|rcsb pdb:2UYI|rcsb pdb:2UYM|rcsb pdb:2WOG|rcsb pdb:2X2R|rcsb pdb:2X7C|rcsb pdb:2X7D|rcsb pdb:2X7E|rcsb pdb:2XAE|rcsb pdb:3CJO|rcsb pdb:3HQD|rcsb pdb:3K3B|rcsb pdb:3K5E|rcsb pdb:3KEN|rcsb pdb:3L9H|rcsb pdb:3WPN|rcsb pdb:3ZCW|rcsb pdb:4A1Z|rcsb pdb:4A28|rcsb pdb:4A50|rcsb pdb:4A51|rcsb pdb:4A5Y|rcsb pdb:4AP0|rcsb pdb:4AQV|rcsb pdb:4AQW|rcsb pdb:4AS7|rcsb pdb:4B7B|rcsb pdb:4BBG|rcsb pdb:4BXN|rcsb pdb:4CK5|rcsb pdb:4CK6|rcsb pdb:4CK7|rcsb pdb:4ZCA|rcsb pdb:4ZHI|rcsb pdb:5JV3|rcsb pdb:5ZO7|rcsb pdb:5ZO8|rcsb pdb:5ZO9|rcsb pdb:6G6Y|rcsb pdb:6G6Z|rcsb pdb:6HKX|rcsb pdb:6HKY|rcsb pdb:6TA3|rcsb pdb:6TA4|rcsb pdb:6TIW|rcsb pdb:6TLE|rcsb pdb:6TRL|rcsb pdb:6Y1I|reactome:R-HSA-2132295|reactome:R-HSA-6811434|reactome:R-HSA-983189|dip:DIP-53686N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:5bgfpxYiGPdno4T5MyJmPCj1e0A9606 rogid:YimbfuWYTSuyqgfs2RF8kCx2+xE9606 intact-crc:9A7C4147C311BF9E|rigid:8plzhcwSiU+qvNi5HBNgrKtqQMk false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P54252-1 uniprotkb:Q96DC9 intact:EBI-946068|ensembl:ENSP00000437157 intact:EBI-746259|uniprotkb:Q9H6T1|uniprotkb:Q6IA10|ensembl:ENSP00000203664|ensembl:ENSP00000478628 psi-mi:p54252-1(display_long)|uniprotkb:ATXN3(gene name)|psi-mi:ATXN3(display_short)|uniprotkb:ATX3(gene name synonym)|uniprotkb:MJD(gene name synonym)|uniprotkb:MJD1(gene name synonym)|uniprotkb:SCA3(gene name synonym)|uniprotkb:Machado-Joseph disease protein 1(gene name synonym)|uniprotkb:Spinocerebellar ataxia type 3 protein(gene name synonym)|uniprotkb:MJD1a(isoform synonym) psi-mi:otub2_human(display_long)|uniprotkb:Otubain-2(gene name synonym)|uniprotkb:OTU domain-containing ubiquitin aldehyde-binding protein 2(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease OTUB2(gene name synonym)|uniprotkb:Deubiquitinating enzyme OTUB2(gene name synonym)|uniprotkb:OTUB2(gene name)|psi-mi:OTUB2(display_short)|uniprotkb:C14orf137(gene name synonym)|uniprotkb:OTB2(gene name synonym)|uniprotkb:OTU2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2509960|imex:IM-12079-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-946046(atx3_human)|ensembl:ENSG00000066427(gene)|ensembl:ENST00000532032(transcript) refseq:NP_075601.1|go:"GO:1901315"(negative regulation of histone H2A K63-linked ubiquitination)|go:"GO:2000780"(negative regulation of double-strand break repair)|interpro:IPR003323(Ovarian tumour, otubain)|interpro:IPR016615(Ubiquitin thioesterase Otubain)|interpro:IPR019400|interpro:IPR030299|interpro:IPR038765|interpro:IPR042467|interpro:IPR042468|rcsb pdb:1TFF|rcsb pdb:4FJV|rcsb pdb:5QIO|rcsb pdb:5QIP|rcsb pdb:5QIQ|rcsb pdb:5QIR|rcsb pdb:5QIS|rcsb pdb:5QIT|rcsb pdb:5QIU|rcsb pdb:5QIV|rcsb pdb:5QIW|rcsb pdb:5QIX|rcsb pdb:5QIY|rcsb pdb:5QIZ|reactome:R-HSA-5689896|ensembl:ENSG00000089723(gene)|ensembl:ENSG00000277276(gene)|ensembl:ENST00000203664(transcript)|ensembl:ENST00000617748(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035871"(protein K11-linked deubiquitination)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination) psi-mi:"MI:0469"(intact) isoform-comment:"Variant in position: 349:YELHVIFALHYSSFPL->Missing (in short isoform 1, due to a stop-gain single nucleotide polymorphism, has reduced half-life due to increased proteasomal degradation, has reduced solubility and increased tendency to form aggregates, increased localization to the nucleus)." - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/01/16 rogid:gFCEB9aqDG+N0hP6xAwf967TUKI9606 rogid:VRoMLaGboqq1kdgtxKBy76srvi09606 intact-crc:C0F0614048389677|rigid:WI7taTtFFbVQoMhoJ4GCFqlw1ts false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P54252-1 uniprotkb:Q92995 intact:EBI-946068|ensembl:ENSP00000437157 intact:EBI-714351|uniprotkb:D3DNS2|uniprotkb:Q96B25|intact:EBI-28978985|ensembl:ENSP00000263966|uniprotkb:A8K2S3|uniprotkb:B4DYF3 psi-mi:p54252-1(display_long)|uniprotkb:ATXN3(gene name)|psi-mi:ATXN3(display_short)|uniprotkb:ATX3(gene name synonym)|uniprotkb:MJD(gene name synonym)|uniprotkb:MJD1(gene name synonym)|uniprotkb:SCA3(gene name synonym)|uniprotkb:Machado-Joseph disease protein 1(gene name synonym)|uniprotkb:Spinocerebellar ataxia type 3 protein(gene name synonym)|uniprotkb:MJD1a(isoform synonym) psi-mi:ubp13_human(display_long)|uniprotkb:Ubiquitin-specific-processing protease 13(gene name synonym)|uniprotkb:Deubiquitinating enzyme 13(gene name synonym)|uniprotkb:Isopeptidase T-3(gene name synonym)|uniprotkb:USP13(gene name)|psi-mi:USP13(display_short)|uniprotkb:ISOT3(gene name synonym)|uniprotkb:Ubiquitin thioesterase 13(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2509960|imex:IM-12079-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-946046(atx3_human)|ensembl:ENSG00000066427(gene)|ensembl:ENST00000532032(transcript) refseq:NP_003931.2|ensembl:ENSG00000058056(gene)|ensembl:ENST00000263966(transcript)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006914"(autophagy)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030318"(melanocyte differentiation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035523"(protein K29-linked deubiquitination)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0044313"(protein K6-linked deubiquitination)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0070628"(proteasome binding)|go:"GO:1904288"(BAT3 complex binding)|go:"GO:1904294"(positive regulation of ERAD pathway)|go:"GO:1904378"(maintenance of unfolded protein involved in ERAD pathway)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR009060(UBA-like)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR016652(Ubiquitinyl hydrolase)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|interpro:IPR041432|rcsb pdb:2L80|rcsb pdb:2LBC|reactome:R-HSA-5689880|reactome:R-HSA-8948751|ensembl:ENSP00000263966|ensembl:ENST00000496897|ensembl:ENSP00000417146|dip:DIP-53511N psi-mi:"MI:0469"(intact) isoform-comment:"Variant in position: 349:YELHVIFALHYSSFPL->Missing (in short isoform 1, due to a stop-gain single nucleotide polymorphism, has reduced half-life due to increased proteasomal degradation, has reduced solubility and increased tendency to form aggregates, increased localization to the nucleus)." - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/01/16 rogid:gFCEB9aqDG+N0hP6xAwf967TUKI9606 rogid:q6g2QmSYm3Xjoo+tv20s6cN8iHk9606 intact-crc:C0F0614048389677|rigid:WI7taTtFFbVQoMhoJ4GCFqlw1ts false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P54252-1 uniprotkb:Q9H3F6 intact:EBI-946068|ensembl:ENSP00000437157 intact:EBI-2505886|uniprotkb:Q53HN2|uniprotkb:Q59FV1|uniprotkb:Q6PL47|uniprotkb:Q96SU0|intact:EBI-2563423|ensembl:ENSP00000228495 psi-mi:p54252-1(display_long)|uniprotkb:ATXN3(gene name)|psi-mi:ATXN3(display_short)|uniprotkb:ATX3(gene name synonym)|uniprotkb:MJD(gene name synonym)|uniprotkb:MJD1(gene name synonym)|uniprotkb:SCA3(gene name synonym)|uniprotkb:Machado-Joseph disease protein 1(gene name synonym)|uniprotkb:Spinocerebellar ataxia type 3 protein(gene name synonym)|uniprotkb:MJD1a(isoform synonym) psi-mi:bacd3_human(display_long)|uniprotkb:BTB/POZ domain-containing protein KCTD10(gene name synonym)|uniprotkb:Potassium channel tetramerization domain-containing protein 10(gene name synonym)|uniprotkb:KCTD10(gene name)|psi-mi:KCTD10(display_short)|uniprotkb:ULR061(gene name synonym)|uniprotkb:MSTP028(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2509960|imex:IM-12079-1 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) intact:EBI-946046(atx3_human)|ensembl:ENSG00000066427(gene)|ensembl:ENST00000532032(transcript) refseq:NP_001304324.1|refseq:NP_001304328.1|refseq:NP_114160.1|ensembl:ENSG00000110906(gene)|ensembl:ENST00000228495(transcript)|go:"GO:0005112"(Notch binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0051260"(protein homooligomerization)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR003131(Potassium channel, voltage dependent, Kv, tetramerisation)|interpro:IPR011333(BTB/POZ fold)|rcsb pdb:5FTA psi-mi:"MI:0469"(intact) isoform-comment:"Variant in position: 349:YELHVIFALHYSSFPL->Missing (in short isoform 1, due to a stop-gain single nucleotide polymorphism, has reduced half-life due to increased proteasomal degradation, has reduced solubility and increased tendency to form aggregates, increased localization to the nucleus)." - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/01/16 rogid:gFCEB9aqDG+N0hP6xAwf967TUKI9606 rogid:ol+Pl17F/3aoKl1CD+edgT9KweI9606 intact-crc:C0F0614048389677|rigid:WI7taTtFFbVQoMhoJ4GCFqlw1ts false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q92560 uniprotkb:Q16576 intact:EBI-1791447|uniprotkb:Q6LEM0|uniprotkb:Q7Z5E8|uniprotkb:A8K993|intact:EBI-2558090|ensembl:ENSP00000417132 intact:EBI-352227|ensembl:ENSP00000369427|intact:EBI-3505029|uniprotkb:Q5JP00 psi-mi:bap1_human(display_long)|uniprotkb:BAP1(gene name)|psi-mi:BAP1(display_short)|uniprotkb:KIAA0272(gene name synonym)|uniprotkb:hucep-6(orf name)|uniprotkb:BRCA1-associated protein 1(gene name synonym)|uniprotkb:Cerebral protein 6(gene name synonym) psi-mi:rbbp7_human(display_long)|uniprotkb:RBBP7(gene name)|psi-mi:RBBP7(display_short)|uniprotkb:RBAP46(gene name synonym)|uniprotkb:Retinoblastoma-binding protein 7(gene name synonym)|uniprotkb:Retinoblastoma-binding protein p46(gene name synonym)|uniprotkb:Histone acetyltransferase type B subunit 2(gene name synonym)|uniprotkb:Nucleosome-remodeling factor subunit RBAP46(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2509989|imex:IM-12079-53 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-47004N|refseq:NP_004647.1|ensembl:ENSG00000163930(gene)|ensembl:ENST00000460680(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0003682"(chromatin binding)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008233"(peptidase activity)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010035"(response to inorganic substance)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035517"(PR-DUB complex)|go:"GO:0035520"(monoubiquitinated protein deubiquitination)|go:"GO:0035522"(monoubiquitinated histone H2A deubiquitination)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0061519"(macrophage homeostasis)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:1900015"(regulation of cytokine production involved in inflammatory response)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|interpro:IPR001578(Peptidase C12, ubiquitin carboxyl-terminal hydrolase 1)|interpro:IPR036959|interpro:IPR038765|interpro:IPR041507|mint:Q92560|reactome:R-HSA-5689603|reactome:R-HSA-5693565 refseq:NP_002884.1|ensembl:ENST00000380087(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006325"(chromatin organization)|go:"GO:0016581"(NuRD complex)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0035098"("ESC/E(Z) complex")|go:"GO:0042393"(histone binding)|go:"GO:0048545"(response to steroid hormone)|go:"GO:0070370"(cellular heat acclimation)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR022052|interpro:IPR036322|mint:Q16576|rcsb pdb:3CFS|rcsb pdb:3CFV|rcsb pdb:7M3X|reactome:R-HSA-212300|reactome:R-HSA-2559580|reactome:R-HSA-3214815|reactome:R-HSA-3214841|reactome:R-HSA-3214847|reactome:R-HSA-3214858|reactome:R-HSA-427389|reactome:R-HSA-5617472|reactome:R-HSA-606279|reactome:R-HSA-6804758|reactome:R-HSA-73762|reactome:R-HSA-8943724|reactome:R-HSA-8951664|reactome:R-HSA-8953750|reactome:R-HSA-9609690|reactome:R-HSA-9679191|reactome:R-HSA-9710421|ensembl:ENSG00000102054(gene)|refseq:NP_001185648.1|dip:DIP-436N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:GMWdT1u5HUl29N+YgC/bCKTbxm49606 rogid:qANLG0ui7jm3Uy4+IRnxR8Kir7c9606 intact-crc:89E9AB79EFAE28D6|rigid:V6jURcKZ46ct04Ne1KJYfQojUX4 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q92560 uniprotkb:Q8IWZ3 intact:EBI-1791447|uniprotkb:Q6LEM0|uniprotkb:Q7Z5E8|uniprotkb:A8K993|intact:EBI-2558090|ensembl:ENSP00000417132 intact:EBI-359558|ensembl:ENSP00000354085|intact:EBI-948598|uniprotkb:A6NH85|uniprotkb:Q149P2|uniprotkb:Q8IWZ2|uniprotkb:Q8WY90|uniprotkb:Q96G77|uniprotkb:Q96GK0|uniprotkb:Q9H2U0|uniprotkb:Q9HA95|uniprotkb:Q9NWG4|uniprotkb:Q9UPR7 psi-mi:bap1_human(display_long)|uniprotkb:BAP1(gene name)|psi-mi:BAP1(display_short)|uniprotkb:KIAA0272(gene name synonym)|uniprotkb:hucep-6(orf name)|uniprotkb:BRCA1-associated protein 1(gene name synonym)|uniprotkb:Cerebral protein 6(gene name synonym) psi-mi:ankh1_human(display_long)|uniprotkb:Multiple ankyrin repeats single KH domain(gene name synonym)|uniprotkb:ANKHD1(gene name)|psi-mi:ANKHD1(display_short)|uniprotkb:HIV-1 Vpr-binding ankyrin repeat protein(gene name synonym)|uniprotkb:KIAA1085(gene name synonym)|uniprotkb:MASK(gene name synonym)|uniprotkb:VBARP(gene name synonym)|uniprotkb:PP2500(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2509989|imex:IM-12079-53 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-47004N|refseq:NP_004647.1|ensembl:ENSG00000163930(gene)|ensembl:ENST00000460680(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0003682"(chromatin binding)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008233"(peptidase activity)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010035"(response to inorganic substance)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035517"(PR-DUB complex)|go:"GO:0035520"(monoubiquitinated protein deubiquitination)|go:"GO:0035522"(monoubiquitinated histone H2A deubiquitination)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0061519"(macrophage homeostasis)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:1900015"(regulation of cytokine production involved in inflammatory response)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|interpro:IPR001578(Peptidase C12, ubiquitin carboxyl-terminal hydrolase 1)|interpro:IPR036959|interpro:IPR038765|interpro:IPR041507|mint:Q92560|reactome:R-HSA-5689603|reactome:R-HSA-5693565 ensembl:ENSG00000131503(gene)|ensembl:ENST00000360839(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0045087"(innate immune response)|interpro:IPR002110(Ankyrin)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR020683|interpro:IPR036612|interpro:IPR036770|refseq:NP_001183959.1|refseq:NP_060217.1|refseq:NP_060448.1|refseq:NP_078944.2|refseq:NP_065741.3|ensembl:ENSP00000354085|ensembl:ENST00000394722|ensembl:ENSP00000378211|ensembl:ENST00000394723|ensembl:ENSP00000378212|ensembl:ENST00000616482|ensembl:ENSP00000478529|dip:DIP-36371N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:GMWdT1u5HUl29N+YgC/bCKTbxm49606 rogid:yPjTR77ttPwAEMg8WHOzYJNcAhA9606 intact-crc:89E9AB79EFAE28D6|rigid:V6jURcKZ46ct04Ne1KJYfQojUX4 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q92560 uniprotkb:O15294 intact:EBI-1791447|uniprotkb:Q6LEM0|uniprotkb:Q7Z5E8|uniprotkb:A8K993|intact:EBI-2558090|ensembl:ENSP00000417132 intact:EBI-539828|uniprotkb:Q7Z3K0|uniprotkb:Q8WWM8|uniprotkb:Q96CC1|uniprotkb:Q9UG57|ensembl:ENSP00000362824 psi-mi:bap1_human(display_long)|uniprotkb:BAP1(gene name)|psi-mi:BAP1(display_short)|uniprotkb:KIAA0272(gene name synonym)|uniprotkb:hucep-6(orf name)|uniprotkb:BRCA1-associated protein 1(gene name synonym)|uniprotkb:Cerebral protein 6(gene name synonym) psi-mi:ogt1_human(display_long)|uniprotkb:O-linked N-acetylglucosamine transferase 110 kDa subunit(gene name synonym)|uniprotkb:O-GlcNAc transferase subunit p110(gene name synonym)|uniprotkb:OGT(gene name)|psi-mi:OGT(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2509989|imex:IM-12079-53 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-47004N|refseq:NP_004647.1|ensembl:ENSG00000163930(gene)|ensembl:ENST00000460680(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0003682"(chromatin binding)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008233"(peptidase activity)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010035"(response to inorganic substance)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035517"(PR-DUB complex)|go:"GO:0035520"(monoubiquitinated protein deubiquitination)|go:"GO:0035522"(monoubiquitinated histone H2A deubiquitination)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0061519"(macrophage homeostasis)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:1900015"(regulation of cytokine production involved in inflammatory response)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|interpro:IPR001578(Peptidase C12, ubiquitin carboxyl-terminal hydrolase 1)|interpro:IPR036959|interpro:IPR038765|interpro:IPR041507|mint:Q92560|reactome:R-HSA-5689603|reactome:R-HSA-5693565 refseq:NP_858058.1|refseq:NP_858059.1|rcsb pdb:3PE3|rcsb pdb:3PE4|rcsb pdb:3TAX|rcsb pdb:4AY5|rcsb pdb:4AY6|rcsb pdb:4CDR|rcsb pdb:4GYW|rcsb pdb:4GYY|rcsb pdb:4GZ3|rcsb pdb:4GZ5|rcsb pdb:4GZ6|rcsb pdb:4N39|rcsb pdb:4N3A|rcsb pdb:1W3B|rcsb pdb:4N3B|rcsb pdb:4N3C|rcsb pdb:4XI9|rcsb pdb:4XIF|rcsb pdb:5BNW|rcsb pdb:5C1D|rcsb pdb:5HGV|rcsb pdb:5LVV|rcsb pdb:5LWV|rcsb pdb:5NPR|rcsb pdb:5NPS|rcsb pdb:5VIE|rcsb pdb:5VIF|rcsb pdb:6E37|rcsb pdb:6EOU|rcsb pdb:6IBO|rcsb pdb:6MA2|rcsb pdb:6MA3|rcsb pdb:6MA4|rcsb pdb:6MA5|rcsb pdb:6Q4M|rcsb pdb:6TKA|reactome:R-HSA-3214847|reactome:R-HSA-5213460|reactome:R-HSA-5675482|reactome:R-HSA-5689603|rcsb pdb:6MA1|ensembl:ENSG00000147162(gene)|ensembl:ENST00000373719(transcript)|go:"GO:0000123"(histone acetyltransferase complex)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006110"(regulation of glycolytic process)|go:"GO:0006111"(regulation of gluconeogenesis)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006493"(protein O-linked glycosylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007584"(response to nutrient)|go:"GO:0008375"(acetylglucosaminyltransferase activity)|go:"GO:0016262"(protein N-acetylglucosaminyltransferase activity)|go:"GO:0016485"(protein processing)|go:"GO:0017122"(protein N-acetylglucosaminyltransferase complex)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032868"(response to insulin)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035020"(regulation of Rac protein signal transduction)|go:"GO:0043981"(histone H4-K5 acetylation)|go:"GO:0043982"(histone H4-K8 acetylation)|go:"GO:0043984"(histone H4-K16 acetylation)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0060544"(regulation of necroptotic process)|go:"GO:0061087"(positive regulation of histone H3-K27 methylation)|go:"GO:0080182"(histone H3-K4 trimethylation)|go:"GO:0097363"(protein O-GlcNAc transferase activity)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR029489|interpro:IPR037919|mint:O15294|go:"GO:0042995"(cell projection)|refseq:XP_016885396.1|refseq:XP_016885397.1|dip:DIP-33491N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:GMWdT1u5HUl29N+YgC/bCKTbxm49606 rogid:NmuVFHeg1QRYMbVav6e7fRJft5U9606 intact-crc:89E9AB79EFAE28D6|rigid:V6jURcKZ46ct04Ne1KJYfQojUX4 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q92560 uniprotkb:Q8NB78 intact:EBI-1791447|uniprotkb:Q6LEM0|uniprotkb:Q7Z5E8|uniprotkb:A8K993|intact:EBI-2558090|ensembl:ENSP00000417132 intact:EBI-2509999|ensembl:ENSP00000499208|uniprotkb:Q6AI15|uniprotkb:Q6ZUU4|uniprotkb:Q96EL7|uniprotkb:Q5TGV3|uniprotkb:Q8N258|uniprotkb:A2A2C5|uniprotkb:A2A2C6 psi-mi:bap1_human(display_long)|uniprotkb:BAP1(gene name)|psi-mi:BAP1(display_short)|uniprotkb:KIAA0272(gene name synonym)|uniprotkb:hucep-6(orf name)|uniprotkb:BRCA1-associated protein 1(gene name synonym)|uniprotkb:Cerebral protein 6(gene name synonym) psi-mi:kdm1b_human(display_long)|uniprotkb:KDM1B(gene name)|psi-mi:KDM1B(display_short)|uniprotkb:C6orf193(gene name synonym)|uniprotkb:AOF1(gene name synonym)|uniprotkb:LSD2(gene name synonym)|uniprotkb:Lysine-specific histone demethylase 2(gene name synonym)|uniprotkb:Flavin-containing amine oxidase domain-containing protein 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2509989|imex:IM-12079-53 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-47004N|refseq:NP_004647.1|ensembl:ENSG00000163930(gene)|ensembl:ENST00000460680(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0003682"(chromatin binding)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008233"(peptidase activity)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010035"(response to inorganic substance)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035517"(PR-DUB complex)|go:"GO:0035520"(monoubiquitinated protein deubiquitination)|go:"GO:0035522"(monoubiquitinated histone H2A deubiquitination)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0061519"(macrophage homeostasis)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:1900015"(regulation of cytokine production involved in inflammatory response)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|interpro:IPR001578(Peptidase C12, ubiquitin carboxyl-terminal hydrolase 1)|interpro:IPR036959|interpro:IPR038765|interpro:IPR041507|mint:Q92560|reactome:R-HSA-5689603|reactome:R-HSA-5693565 ensembl:ENSG00000165097(gene)|ensembl:ENST00000650836(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000786"(nucleosome)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006349"(regulation of gene expression by genomic imprinting)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0032452"(histone demethylase activity)|go:"GO:0034648"("obsolete histone demethylase activity (H3-dimethyl-K4 specific)")|go:"GO:0034649"("obsolete histone demethylase activity (H3-monomethyl-K4 specific)")|go:"GO:0034720"(histone H3-K4 demethylation)|go:"GO:0042393"(histone binding)|go:"GO:0043046"(DNA methylation involved in gamete generation)|go:"GO:0044030"(regulation of DNA methylation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050660"(flavin adenine dinucleotide binding)|go:"GO:0071949"(FAD binding)|interpro:IPR002937(Amine oxidase)|interpro:IPR007526(SWIRM)|interpro:IPR009057(Homeodomain-like)|interpro:IPR011124(Zinc finger, CW-type)|interpro:IPR036188|interpro:IPR036388|rcsb pdb:4FWE|rcsb pdb:4FWF|rcsb pdb:4FWJ|rcsb pdb:4GU0|rcsb pdb:4GU1|rcsb pdb:4GUR|rcsb pdb:4GUS|rcsb pdb:4GUT|rcsb pdb:4GUU|rcsb pdb:4HSU|rcsb pdb:6R1U|rcsb pdb:6R25|reactome:R-HSA-3214842|reactome:R-HSA-5689603|reactome:R-HSA-9029569|refseq:NP_694587.3|refseq:XP_005248983.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:GMWdT1u5HUl29N+YgC/bCKTbxm49606 rogid:37lP46UxrdbQmFoKabg6UdpVETg9606 intact-crc:89E9AB79EFAE28D6|rigid:V6jURcKZ46ct04Ne1KJYfQojUX4 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q92560 uniprotkb:Q8IXJ9 intact:EBI-1791447|uniprotkb:Q6LEM0|uniprotkb:Q7Z5E8|uniprotkb:A8K993|intact:EBI-2558090|ensembl:ENSP00000417132 intact:EBI-1646500|uniprotkb:Q5JWS9|uniprotkb:Q8IYY7|uniprotkb:Q9H466|uniprotkb:Q9NQF8|uniprotkb:Q9UFJ0|uniprotkb:Q9UFP8|uniprotkb:Q9Y2I4|uniprotkb:B2RP59|ensembl:ENSP00000364839|ensembl:ENSP00000480487|ensembl:ENSP00000481978 psi-mi:bap1_human(display_long)|uniprotkb:BAP1(gene name)|psi-mi:BAP1(display_short)|uniprotkb:KIAA0272(gene name synonym)|uniprotkb:hucep-6(orf name)|uniprotkb:BRCA1-associated protein 1(gene name synonym)|uniprotkb:Cerebral protein 6(gene name synonym) psi-mi:asxl1_human(display_long)|uniprotkb:ASXL1(gene name)|psi-mi:ASXL1(display_short)|uniprotkb:KIAA0978(gene name synonym)|uniprotkb:Additional sex combs-like protein 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2509989|imex:IM-12079-53 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-47004N|refseq:NP_004647.1|ensembl:ENSG00000163930(gene)|ensembl:ENST00000460680(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0003682"(chromatin binding)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008233"(peptidase activity)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010035"(response to inorganic substance)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035517"(PR-DUB complex)|go:"GO:0035520"(monoubiquitinated protein deubiquitination)|go:"GO:0035522"(monoubiquitinated histone H2A deubiquitination)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0061519"(macrophage homeostasis)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:1900015"(regulation of cytokine production involved in inflammatory response)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|interpro:IPR001578(Peptidase C12, ubiquitin carboxyl-terminal hydrolase 1)|interpro:IPR036959|interpro:IPR038765|interpro:IPR041507|mint:Q92560|reactome:R-HSA-5689603|reactome:R-HSA-5693565 refseq:NP_056153.2|ensembl:ENSP00000364839|ensembl:ENSP00000480487|ensembl:ENSP00000481978|dip:DIP-46910N|ensembl:ENSG00000171456(gene)|ensembl:ENST00000375687(transcript)|ensembl:ENST00000613218(transcript)|ensembl:ENST00000620121(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010888"(negative regulation of lipid storage)|go:"GO:0030097"(hemopoiesis)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0035359"(negative regulation of peroxisome proliferator activated receptor signaling pathway)|go:"GO:0035517"(PR-DUB complex)|go:"GO:0035522"(monoubiquitinated histone H2A deubiquitination)|go:"GO:0035564"(regulation of kidney size)|go:"GO:0042974"(retinoic acid receptor binding)|go:"GO:0042975"(peroxisome proliferator activated receptor binding)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048538"(thymus development)|go:"GO:0048539"(bone marrow development)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0060430"(lung saccule development)|go:"GO:0072015"(glomerular visceral epithelial cell development)|interpro:IPR007759(DNA-directed RNA polymerase delta subunit)|interpro:IPR024811|interpro:IPR024815|interpro:IPR026905|interpro:IPR028020|interpro:IPR044867|reactome:R-HSA-5689603|go:"GO:0048386"(positive regulation of retinoic acid receptor signaling pathway) psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:GMWdT1u5HUl29N+YgC/bCKTbxm49606 rogid:6YpSgdOhNRawROUe3W0t72u6JfA9606 intact-crc:89E9AB79EFAE28D6|rigid:V6jURcKZ46ct04Ne1KJYfQojUX4 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q92560 uniprotkb:O14929 intact:EBI-1791447|uniprotkb:Q6LEM0|uniprotkb:Q7Z5E8|uniprotkb:A8K993|intact:EBI-2558090|ensembl:ENSP00000417132 intact:EBI-2339359|uniprotkb:Q53SU4|uniprotkb:Q53QF0|uniprotkb:Q49A44|uniprotkb:Q6P594|uniprotkb:Q8WWB9|ensembl:ENSP00000264108 psi-mi:bap1_human(display_long)|uniprotkb:BAP1(gene name)|psi-mi:BAP1(display_short)|uniprotkb:KIAA0272(gene name synonym)|uniprotkb:hucep-6(orf name)|uniprotkb:BRCA1-associated protein 1(gene name synonym)|uniprotkb:Cerebral protein 6(gene name synonym) psi-mi:hat1_human(display_long)|uniprotkb:HAT1(gene name)|psi-mi:HAT1(display_short)|uniprotkb:KAT1(gene name synonym)|uniprotkb:Histone acetyltransferase 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2509989|imex:IM-12079-53 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-47004N|refseq:NP_004647.1|ensembl:ENSG00000163930(gene)|ensembl:ENST00000460680(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0003682"(chromatin binding)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008233"(peptidase activity)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010035"(response to inorganic substance)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035517"(PR-DUB complex)|go:"GO:0035520"(monoubiquitinated protein deubiquitination)|go:"GO:0035522"(monoubiquitinated histone H2A deubiquitination)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0061519"(macrophage homeostasis)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:1900015"(regulation of cytokine production involved in inflammatory response)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|interpro:IPR001578(Peptidase C12, ubiquitin carboxyl-terminal hydrolase 1)|interpro:IPR036959|interpro:IPR038765|interpro:IPR041507|mint:Q92560|reactome:R-HSA-5689603|reactome:R-HSA-5693565 refseq:NP_003633.1|dip:DIP-52811N|ensembl:ENSG00000128708(gene)|ensembl:ENST00000264108(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0004402"(histone acetyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006323"(DNA packaging)|go:"GO:0006335"(DNA replication-dependent chromatin assembly)|go:"GO:0006336"(DNA replication-independent chromatin assembly)|go:"GO:0006348"|go:"GO:0006475"(internal protein amino acid acetylation)|go:"GO:0007584"(response to nutrient)|go:"GO:0010485"(H4 histone acetyltransferase activity)|go:"GO:0016363"(nuclear matrix)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042393"(histone binding)|go:"GO:0043967"(histone H4 acetylation)|interpro:IPR013523(Histone acetyltransferase HAT1, C-terminal)|interpro:IPR016181(Acyl-CoA N-acyltransferase)|interpro:IPR017380(Histone acetyltransferase type B, catalytic subunit)|interpro:IPR019467|interpro:IPR037113|mint:O14929|rcsb pdb:2P0W|rcsb pdb:6VO5|reactome:R-HSA-3214847 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:GMWdT1u5HUl29N+YgC/bCKTbxm49606 rogid:80KgRaid3NeRfAUdTHMQ/r0VuGo9606 intact-crc:89E9AB79EFAE28D6|rigid:V6jURcKZ46ct04Ne1KJYfQojUX4 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q92560 uniprotkb:Q76L83 intact:EBI-1791447|uniprotkb:Q6LEM0|uniprotkb:Q7Z5E8|uniprotkb:A8K993|intact:EBI-2558090|ensembl:ENSP00000417132 intact:EBI-1058437|uniprotkb:Q76L81|uniprotkb:Q9C0H8|uniprotkb:Q9NV67|uniprotkb:Q53TC9|uniprotkb:Q5H9U4|uniprotkb:Q86XM1|intact:EBI-2558098|intact:EBI-2509978|ensembl:ENSP00000391447 psi-mi:bap1_human(display_long)|uniprotkb:BAP1(gene name)|psi-mi:BAP1(display_short)|uniprotkb:KIAA0272(gene name synonym)|uniprotkb:hucep-6(orf name)|uniprotkb:BRCA1-associated protein 1(gene name synonym)|uniprotkb:Cerebral protein 6(gene name synonym) psi-mi:asxl2_human(display_long)|uniprotkb:ASXL2(gene name)|psi-mi:ASXL2(display_short)|uniprotkb:ASXH2(gene name synonym)|uniprotkb:KIAA1685(gene name synonym)|uniprotkb:Additional sex combs-like protein 2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2509989|imex:IM-12079-53 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-47004N|refseq:NP_004647.1|ensembl:ENSG00000163930(gene)|ensembl:ENST00000460680(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0003682"(chromatin binding)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008233"(peptidase activity)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010035"(response to inorganic substance)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035517"(PR-DUB complex)|go:"GO:0035520"(monoubiquitinated protein deubiquitination)|go:"GO:0035522"(monoubiquitinated histone H2A deubiquitination)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0061519"(macrophage homeostasis)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:1900015"(regulation of cytokine production involved in inflammatory response)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|interpro:IPR001578(Peptidase C12, ubiquitin carboxyl-terminal hydrolase 1)|interpro:IPR036959|interpro:IPR038765|interpro:IPR041507|mint:Q92560|reactome:R-HSA-5689603|reactome:R-HSA-5693565 refseq:NP_060733.4|ensembl:ENSG00000143970(gene)|ensembl:ENST00000435504(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010884"(positive regulation of lipid storage)|go:"GO:0035360"(positive regulation of peroxisome proliferator activated receptor signaling pathway)|go:"GO:0035517"(PR-DUB complex)|go:"GO:0042975"(peroxisome proliferator activated receptor binding)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|interpro:IPR007759(DNA-directed RNA polymerase delta subunit)|interpro:IPR024811|interpro:IPR024817|interpro:IPR026905|interpro:IPR028020|interpro:IPR044867|reactome:R-HSA-5689603 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:GMWdT1u5HUl29N+YgC/bCKTbxm49606 rogid:O3e0oxBNha1iPYIYsUBSLGP0GPQ9606 intact-crc:89E9AB79EFAE28D6|rigid:V6jURcKZ46ct04Ne1KJYfQojUX4 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q92560 uniprotkb:P85037 intact:EBI-1791447|uniprotkb:Q6LEM0|uniprotkb:Q7Z5E8|uniprotkb:A8K993|intact:EBI-2558090|ensembl:ENSP00000417132 intact:EBI-2509974|ensembl:ENSP00000328720 psi-mi:bap1_human(display_long)|uniprotkb:BAP1(gene name)|psi-mi:BAP1(display_short)|uniprotkb:KIAA0272(gene name synonym)|uniprotkb:hucep-6(orf name)|uniprotkb:BRCA1-associated protein 1(gene name synonym)|uniprotkb:Cerebral protein 6(gene name synonym) psi-mi:foxk1_human(display_long)|uniprotkb:FOXK1(gene name)|psi-mi:FOXK1(display_short)|uniprotkb:MNF(gene name synonym)|uniprotkb:Myocyte nuclear factor(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2509989|imex:IM-12079-53 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-47004N|refseq:NP_004647.1|ensembl:ENSG00000163930(gene)|ensembl:ENST00000460680(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0003682"(chromatin binding)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008233"(peptidase activity)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010035"(response to inorganic substance)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035517"(PR-DUB complex)|go:"GO:0035520"(monoubiquitinated protein deubiquitination)|go:"GO:0035522"(monoubiquitinated histone H2A deubiquitination)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0061519"(macrophage homeostasis)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:1900015"(regulation of cytokine production involved in inflammatory response)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|interpro:IPR001578(Peptidase C12, ubiquitin carboxyl-terminal hydrolase 1)|interpro:IPR036959|interpro:IPR038765|interpro:IPR041507|mint:Q92560|reactome:R-HSA-5689603|reactome:R-HSA-5693565 ensembl:ENSG00000164916(gene)|ensembl:ENST00000328914(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007517"(muscle organ development)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010906"(regulation of glucose metabolic process)|go:"GO:0030154"(cell differentiation)|go:"GO:0042594"(response to starvation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0061621"(canonical glycolysis)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000253(Forkhead-associated)|interpro:IPR001766(Fork head transcription factor)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR018122|interpro:IPR030456|interpro:IPR036388|interpro:IPR036390|reactome:R-HSA-5689603|refseq:XP_011513493.1|refseq:NP_001032242.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:GMWdT1u5HUl29N+YgC/bCKTbxm49606 rogid:ngoE3oNlIDGkTf1ZMYG4OQ6lvE09606 intact-crc:89E9AB79EFAE28D6|rigid:V6jURcKZ46ct04Ne1KJYfQojUX4 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q92560 uniprotkb:Q13185 intact:EBI-1791447|uniprotkb:Q6LEM0|uniprotkb:Q7Z5E8|uniprotkb:A8K993|intact:EBI-2558090|ensembl:ENSP00000417132 intact:EBI-78176|ensembl:ENSP00000336687|ensembl:ENSP00000379670|uniprotkb:Q96CD7|uniprotkb:Q99409|uniprotkb:Q9BVS3|uniprotkb:Q9P0Z6 psi-mi:bap1_human(display_long)|uniprotkb:BAP1(gene name)|psi-mi:BAP1(display_short)|uniprotkb:KIAA0272(gene name synonym)|uniprotkb:hucep-6(orf name)|uniprotkb:BRCA1-associated protein 1(gene name synonym)|uniprotkb:Cerebral protein 6(gene name synonym) psi-mi:cbx3_human(display_long)|uniprotkb:CBX3(gene name)|psi-mi:CBX3(display_short)|uniprotkb:Heterochromatin protein 1 homolog gamma(gene name synonym)|uniprotkb:Modifier 2 protein(gene name synonym)|uniprotkb:HECH(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2509989|imex:IM-12079-53 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-47004N|refseq:NP_004647.1|ensembl:ENSG00000163930(gene)|ensembl:ENST00000460680(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0003682"(chromatin binding)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008233"(peptidase activity)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010035"(response to inorganic substance)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035517"(PR-DUB complex)|go:"GO:0035520"(monoubiquitinated protein deubiquitination)|go:"GO:0035522"(monoubiquitinated histone H2A deubiquitination)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0061519"(macrophage homeostasis)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:1900015"(regulation of cytokine production involved in inflammatory response)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|interpro:IPR001578(Peptidase C12, ubiquitin carboxyl-terminal hydrolase 1)|interpro:IPR036959|interpro:IPR038765|interpro:IPR041507|mint:Q92560|reactome:R-HSA-5689603|reactome:R-HSA-5693565 go:"GO:0000791"(euchromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|ensembl:ENSG00000122565(gene)|ensembl:ENST00000337620(transcript)|ensembl:ENST00000396386(transcript)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000779"(condensed chromosome, centromeric region)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0005819"(spindle)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048511"(rhythmic process)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0090734"(site of DNA damage)|go:"GO:1990226"(histone methyltransferase binding)|interpro:IPR000953(Chromo domain)|interpro:IPR008251(Chromo shadow)|interpro:IPR016197(Chromo domain-like)|interpro:IPR017984|interpro:IPR023779|interpro:IPR023780|interpro:IPR038033|mint:Q13185|rcsb pdb:2L11|rcsb pdb:3DM1|rcsb pdb:3KUP|rcsb pdb:3TZD|go:"GO:0005637"(nuclear inner membrane)|rcsb pdb:6HW2|reactome:R-HSA-427389|reactome:R-HSA-73772|reactome:R-HSA-8953750|rcsb pdb:5T1I|refseq:NP_009207.2|refseq:NP_057671.2|refseq:XP_005249668.1|dip:DIP-5985N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:GMWdT1u5HUl29N+YgC/bCKTbxm49606 rogid:6L5OQHfxCBkmPV5Z0XihmXx4mFQ9606 intact-crc:89E9AB79EFAE28D6|rigid:V6jURcKZ46ct04Ne1KJYfQojUX4 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q92560 uniprotkb:Q01167 intact:EBI-1791447|uniprotkb:Q6LEM0|uniprotkb:Q7Z5E8|uniprotkb:A8K993|intact:EBI-2558090|ensembl:ENSP00000417132 intact:EBI-2509991|intact:EBI-28976610|ensembl:ENSP00000335677|uniprotkb:Q13624|uniprotkb:Q13623|uniprotkb:A6NEP5|uniprotkb:Q13622 psi-mi:bap1_human(display_long)|uniprotkb:BAP1(gene name)|psi-mi:BAP1(display_short)|uniprotkb:KIAA0272(gene name synonym)|uniprotkb:hucep-6(orf name)|uniprotkb:BRCA1-associated protein 1(gene name synonym)|uniprotkb:Cerebral protein 6(gene name synonym) psi-mi:foxk2_human(display_long)|uniprotkb:G/T-mismatch specific binding protein(gene name synonym)|uniprotkb:FOXK2(gene name)|psi-mi:FOXK2(display_short)|uniprotkb:ILF(gene name synonym)|uniprotkb:ILF1(gene name synonym)|uniprotkb:Interleukin enhancer-binding factor 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2509989|imex:IM-12079-53 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-47004N|refseq:NP_004647.1|ensembl:ENSG00000163930(gene)|ensembl:ENST00000460680(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0003682"(chromatin binding)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008233"(peptidase activity)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010035"(response to inorganic substance)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035517"(PR-DUB complex)|go:"GO:0035520"(monoubiquitinated protein deubiquitination)|go:"GO:0035522"(monoubiquitinated histone H2A deubiquitination)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0061519"(macrophage homeostasis)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:1900015"(regulation of cytokine production involved in inflammatory response)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|interpro:IPR001578(Peptidase C12, ubiquitin carboxyl-terminal hydrolase 1)|interpro:IPR036959|interpro:IPR038765|interpro:IPR041507|mint:Q92560|reactome:R-HSA-5689603|reactome:R-HSA-5693565 ensembl:ENSG00000141568(gene)|ensembl:ENST00000335255(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010906"(regulation of glucose metabolic process)|go:"GO:0042594"(response to starvation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|interpro:IPR000253(Forkhead-associated)|interpro:IPR001766(Fork head transcription factor)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR018122|go:"GO:0061621"(canonical glycolysis)|interpro:IPR030456|interpro:IPR036388|interpro:IPR036390|mint:Q01167|rcsb pdb:1JXS|rcsb pdb:2C6Y|reactome:R-HSA-5689603|ensembl:ENSP00000335677|ensembl:ENST00000473637|ensembl:ENSP00000436108|refseq:NP_004505.2 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:GMWdT1u5HUl29N+YgC/bCKTbxm49606 rogid:mGYtlnM3enVAuU82j5hQ0sui3F49606 intact-crc:89E9AB79EFAE28D6|rigid:V6jURcKZ46ct04Ne1KJYfQojUX4 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q92560 uniprotkb:P61289 intact:EBI-1791447|uniprotkb:Q6LEM0|uniprotkb:Q7Z5E8|uniprotkb:A8K993|intact:EBI-2558090|ensembl:ENSP00000417132 intact:EBI-355546|uniprotkb:O35563|uniprotkb:P97373|uniprotkb:Q12920|uniprotkb:Q13172|uniprotkb:Q9BQD9|uniprotkb:A8K9A3|ensembl:ENSP00000466794 psi-mi:bap1_human(display_long)|uniprotkb:BAP1(gene name)|psi-mi:BAP1(display_short)|uniprotkb:KIAA0272(gene name synonym)|uniprotkb:hucep-6(orf name)|uniprotkb:BRCA1-associated protein 1(gene name synonym)|uniprotkb:Cerebral protein 6(gene name synonym) psi-mi:psme3_human(display_long)|uniprotkb:PSME3(gene name)|psi-mi:PSME3(display_short)|uniprotkb:Proteasome activator 28 subunit gamma(gene name synonym)|uniprotkb:Activator of multicatalytic protease subunit 3(gene name synonym)|uniprotkb:11S regulator complex subunit gamma(gene name synonym)|uniprotkb:Ki nuclear autoantigen(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2509989|imex:IM-12079-53 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-47004N|refseq:NP_004647.1|ensembl:ENSG00000163930(gene)|ensembl:ENST00000460680(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0003682"(chromatin binding)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008233"(peptidase activity)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010035"(response to inorganic substance)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035517"(PR-DUB complex)|go:"GO:0035520"(monoubiquitinated protein deubiquitination)|go:"GO:0035522"(monoubiquitinated histone H2A deubiquitination)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0061519"(macrophage homeostasis)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:1900015"(regulation of cytokine production involved in inflammatory response)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|interpro:IPR001578(Peptidase C12, ubiquitin carboxyl-terminal hydrolase 1)|interpro:IPR036959|interpro:IPR038765|interpro:IPR041507|mint:Q92560|reactome:R-HSA-5689603|reactome:R-HSA-5693565 refseq:NP_005780.2|refseq:NP_789839.1|ensembl:ENSG00000131467(gene)|ensembl:ENST00000590720(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0002039"(p53 binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0008537"(proteasome activator complex)|go:"GO:0010950"(positive regulation of endopeptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0061133"(endopeptidase activator activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR003185(Proteasome activator pa28, REG alpha subunit)|interpro:IPR003186(Proteasome activator pa28, REG beta subunit)|interpro:IPR009077(Proteasome activator pa28, REG alpha/beta subunit)|interpro:IPR036252|interpro:IPR036996|interpro:IPR036997|mint:P61289|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:GMWdT1u5HUl29N+YgC/bCKTbxm49606 rogid:6EQY2Kj3Juf++m4eBDzPWMgbC2k9606 intact-crc:89E9AB79EFAE28D6|rigid:V6jURcKZ46ct04Ne1KJYfQojUX4 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q92560 uniprotkb:O00410 intact:EBI-1791447|uniprotkb:Q6LEM0|uniprotkb:Q7Z5E8|uniprotkb:A8K993|intact:EBI-2558090|ensembl:ENSP00000417132 intact:EBI-356424|uniprotkb:O15257|intact:EBI-1105173|uniprotkb:B4DZA0|uniprotkb:Q5T578|uniprotkb:Q86XC7|ensembl:ENSP00000350219|ensembl:ENSP00000418393|ensembl:ENSP00000499125 psi-mi:bap1_human(display_long)|uniprotkb:BAP1(gene name)|psi-mi:BAP1(display_short)|uniprotkb:KIAA0272(gene name synonym)|uniprotkb:hucep-6(orf name)|uniprotkb:BRCA1-associated protein 1(gene name synonym)|uniprotkb:Cerebral protein 6(gene name synonym) psi-mi:ipo5_human(display_long)|uniprotkb:IPO5(gene name)|psi-mi:IPO5(display_short)|uniprotkb:KPNB3(gene name synonym)|uniprotkb:RANBP5(gene name synonym)|uniprotkb:Importin subunit beta-3(gene name synonym)|uniprotkb:Karyopherin beta-3(gene name synonym)|uniprotkb:Ran-binding protein 5(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2509989|imex:IM-12079-53 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-47004N|refseq:NP_004647.1|ensembl:ENSG00000163930(gene)|ensembl:ENST00000460680(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0003682"(chromatin binding)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008233"(peptidase activity)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010035"(response to inorganic substance)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035517"(PR-DUB complex)|go:"GO:0035520"(monoubiquitinated protein deubiquitination)|go:"GO:0035522"(monoubiquitinated histone H2A deubiquitination)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0061519"(macrophage homeostasis)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:1900015"(regulation of cytokine production involved in inflammatory response)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|interpro:IPR001578(Peptidase C12, ubiquitin carboxyl-terminal hydrolase 1)|interpro:IPR036959|interpro:IPR038765|interpro:IPR041507|mint:Q92560|reactome:R-HSA-5689603|reactome:R-HSA-5693565 refseq:NP_002262.3|refseq:XP_011519389.1|refseq:XP_011519390.1|refseq:XP_011519391.1|refseq:XP_011519392.1|ensembl:ENSG00000065150(gene)|ensembl:ENST00000357602(transcript)|ensembl:ENST00000490680(transcript)|ensembl:ENST00000651721(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005095"(GTPase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005643"(nuclear pore)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006607"(NLS-bearing protein import into nucleus)|go:"GO:0006610"(ribosomal protein import into nucleus)|go:"GO:0008139"(nuclear localization sequence binding)|refseq:XP_005254109.1|refseq:XP_005254110.1|go:"GO:0016020"(membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0061608"(nuclear import signal receptor activity)|go:"GO:0071230"(cellular response to amino acid stimulus)|interpro:IPR000357(HEAT)|interpro:IPR001494(Importin-beta, N-terminal)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR034085|interpro:IPR040122|interpro:IPR040928|interpro:IPR041389|interpro:IPR041653|mint:O00410|rcsb pdb:6XTE|rcsb pdb:6XU2|reactome:R-HSA-192905|refseq:XP_016876051.1|dip:DIP-41042N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:GMWdT1u5HUl29N+YgC/bCKTbxm49606 rogid:jBYLvkqyYyWAu1TdCVyCMh9ZHKY9606 intact-crc:89E9AB79EFAE28D6|rigid:V6jURcKZ46ct04Ne1KJYfQojUX4 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q92560 uniprotkb:P51610 intact:EBI-1791447|uniprotkb:Q6LEM0|uniprotkb:Q7Z5E8|uniprotkb:A8K993|intact:EBI-2558090|ensembl:ENSP00000417132 intact:EBI-396176|intact:EBI-2832627|uniprotkb:Q6P4G5|intact:EBI-12037257|intact:EBI-14324845|ensembl:ENSP00000309555|intact:EBI-12980473 psi-mi:bap1_human(display_long)|uniprotkb:BAP1(gene name)|psi-mi:BAP1(display_short)|uniprotkb:KIAA0272(gene name synonym)|uniprotkb:hucep-6(orf name)|uniprotkb:BRCA1-associated protein 1(gene name synonym)|uniprotkb:Cerebral protein 6(gene name synonym) psi-mi:hcfc1_human(display_long)|uniprotkb:HCFC1(gene name)|psi-mi:HCFC1(display_short)|uniprotkb:HCF1(gene name synonym)|uniprotkb:C1 factor(gene name synonym)|uniprotkb:VP16 accessory protein(gene name synonym)|uniprotkb:VCAF(gene name synonym)|uniprotkb:CFF(gene name synonym)|uniprotkb:HFC1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2509989|imex:IM-12079-53 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-47004N|refseq:NP_004647.1|ensembl:ENSG00000163930(gene)|ensembl:ENST00000460680(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0003682"(chromatin binding)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008233"(peptidase activity)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010035"(response to inorganic substance)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035517"(PR-DUB complex)|go:"GO:0035520"(monoubiquitinated protein deubiquitination)|go:"GO:0035522"(monoubiquitinated histone H2A deubiquitination)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0061519"(macrophage homeostasis)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:1900015"(regulation of cytokine production involved in inflammatory response)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|interpro:IPR001578(Peptidase C12, ubiquitin carboxyl-terminal hydrolase 1)|interpro:IPR036959|interpro:IPR038765|interpro:IPR041507|mint:Q92560|reactome:R-HSA-5689603|reactome:R-HSA-5693565 refseq:NP_005325.2|refseq:XP_006724879.1|rcsb pdb:6MA1|rcsb pdb:6MA2|rcsb pdb:6MA3|rcsb pdb:6MA4|rcsb pdb:6MA5|reactome:R-HSA-2151201|reactome:R-HSA-3214847|reactome:R-HSA-5689603|ensembl:ENSG00000172534(gene)|ensembl:ENST00000310441(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000123"(histone acetyltransferase complex)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007049"(cell cycle)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0019046"(release from viral latency)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043981"(histone H4-K5 acetylation)|go:"GO:0043982"(histone H4-K8 acetylation)|go:"GO:0043984"(histone H4-K16 acetylation)|go:"GO:0045296"(cadherin binding)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048188"(Set1C/COMPASS complex)|go:"GO:0050821"(protein stabilization)|go:"GO:0071339"(MLL1 complex)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015915(Kelch-type beta propeller)|interpro:IPR036116|interpro:IPR037854|interpro:IPR043536|mint:P51610|rcsb pdb:4GO6|rcsb pdb:4N39|rcsb pdb:4N3A|rcsb pdb:4N3B|rcsb pdb:4N3C|rcsb pdb:5LWV|dip:DIP-32955N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:GMWdT1u5HUl29N+YgC/bCKTbxm49606 rogid:RzsCRe9l6md3DI87H4ZgdR9oBMI9606 intact-crc:89E9AB79EFAE28D6|rigid:V6jURcKZ46ct04Ne1KJYfQojUX4 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q92560 uniprotkb:Q9C0C9 intact:EBI-1791447|uniprotkb:Q6LEM0|uniprotkb:Q7Z5E8|uniprotkb:A8K993|intact:EBI-2558090|ensembl:ENSP00000417132 intact:EBI-2339946|uniprotkb:Q8N425|uniprotkb:Q9H9B2|uniprotkb:Q6PIZ2|uniprotkb:Q9H7E4|uniprotkb:Q8TBN1|uniprotkb:A6NDU5|uniprotkb:Q9BSW1|uniprotkb:Q69YP4|uniprotkb:Q86UA4|uniprotkb:Q9H6E6|ensembl:ENSP00000323687 psi-mi:bap1_human(display_long)|uniprotkb:BAP1(gene name)|psi-mi:BAP1(display_short)|uniprotkb:KIAA0272(gene name synonym)|uniprotkb:hucep-6(orf name)|uniprotkb:BRCA1-associated protein 1(gene name synonym)|uniprotkb:Cerebral protein 6(gene name synonym) psi-mi:ube2o_human(display_long)|uniprotkb:UBE2O(gene name)|psi-mi:UBE2O(display_short)|uniprotkb:KIAA1734(gene name synonym)|uniprotkb:Ubiquitin-protein ligase O(gene name synonym)|uniprotkb:Ubiquitin carrier protein O(gene name synonym)|uniprotkb:Ubiquitin-conjugating enzyme E2 of 230 kDa(gene name synonym)|uniprotkb:Ubiquitin-conjugating enzyme E2 O(gene name synonym)|uniprotkb:E2/E3 hybrid ubiquitin-protein ligase UBE2O(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2509989|imex:IM-12079-53 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-47004N|refseq:NP_004647.1|ensembl:ENSG00000163930(gene)|ensembl:ENST00000460680(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0003682"(chromatin binding)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008233"(peptidase activity)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010035"(response to inorganic substance)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035517"(PR-DUB complex)|go:"GO:0035520"(monoubiquitinated protein deubiquitination)|go:"GO:0035522"(monoubiquitinated histone H2A deubiquitination)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0061519"(macrophage homeostasis)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:1900015"(regulation of cytokine production involved in inflammatory response)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|interpro:IPR001578(Peptidase C12, ubiquitin carboxyl-terminal hydrolase 1)|interpro:IPR036959|interpro:IPR038765|interpro:IPR041507|mint:Q92560|reactome:R-HSA-5689603|reactome:R-HSA-5693565 refseq:NP_071349.3|ensembl:ENSG00000175931(gene)|ensembl:ENST00000319380(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0004869"(cysteine-type endopeptidase inhibitor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|mint:Q9C0C9|reactome:R-HSA-983168 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:GMWdT1u5HUl29N+YgC/bCKTbxm49606 rogid:FftBetvip/qFQAsQxmxRnGy8ctA9606 intact-crc:89E9AB79EFAE28D6|rigid:V6jURcKZ46ct04Ne1KJYfQojUX4 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q92560 uniprotkb:Q8TEX9 intact:EBI-1791447|uniprotkb:Q6LEM0|uniprotkb:Q7Z5E8|uniprotkb:A8K993|intact:EBI-2558090|ensembl:ENSP00000417132 intact:EBI-395967|uniprotkb:Q2NL96|uniprotkb:Q86TZ9|uniprotkb:Q8NCG8|uniprotkb:Q96SJ3|uniprotkb:Q9BTI4|uniprotkb:Q9H5L0|uniprotkb:B2RN95|ensembl:ENSP00000346453|ensembl:ENSP00000494795 psi-mi:bap1_human(display_long)|uniprotkb:BAP1(gene name)|psi-mi:BAP1(display_short)|uniprotkb:KIAA0272(gene name synonym)|uniprotkb:hucep-6(orf name)|uniprotkb:BRCA1-associated protein 1(gene name synonym)|uniprotkb:Cerebral protein 6(gene name synonym) psi-mi:ipo4_human(display_long)|uniprotkb:IPO4(gene name)|psi-mi:IPO4(display_short)|uniprotkb:IMP4B(gene name synonym)|uniprotkb:RANBP4(gene name synonym)|uniprotkb:Importin-4b(gene name synonym)|uniprotkb:Ran-binding protein 4(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2509989|imex:IM-12079-53 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-47004N|refseq:NP_004647.1|ensembl:ENSG00000163930(gene)|ensembl:ENST00000460680(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0003682"(chromatin binding)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008233"(peptidase activity)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010035"(response to inorganic substance)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035517"(PR-DUB complex)|go:"GO:0035520"(monoubiquitinated protein deubiquitination)|go:"GO:0035522"(monoubiquitinated histone H2A deubiquitination)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0061519"(macrophage homeostasis)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:1900015"(regulation of cytokine production involved in inflammatory response)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|interpro:IPR001578(Peptidase C12, ubiquitin carboxyl-terminal hydrolase 1)|interpro:IPR036959|interpro:IPR038765|interpro:IPR041507|mint:Q92560|reactome:R-HSA-5689603|reactome:R-HSA-5693565 refseq:NP_078934.3|dip:DIP-32944N|ensembl:ENSG00000196497(gene)|ensembl:ENSG00000285248(gene)|ensembl:ENST00000354464(transcript)|ensembl:ENST00000644546(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006335"(DNA replication-dependent chromatin assembly)|go:"GO:0006336"(DNA replication-independent chromatin assembly)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0016020"(membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0061608"(nuclear import signal receptor activity)|interpro:IPR000357(HEAT)|interpro:IPR001494(Importin-beta, N-terminal)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR021133|interpro:IPR034085|interpro:IPR040122|mint:Q8TEX9|rcsb pdb:5XAH|rcsb pdb:5XBK psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:GMWdT1u5HUl29N+YgC/bCKTbxm49606 rogid:PVIcGG3WTf0QmYbS0vvy049EjlQ9606 intact-crc:89E9AB79EFAE28D6|rigid:V6jURcKZ46ct04Ne1KJYfQojUX4 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q92560 uniprotkb:O75179 intact:EBI-1791447|uniprotkb:Q6LEM0|uniprotkb:Q7Z5E8|uniprotkb:A8K993|intact:EBI-2558090|ensembl:ENSP00000417132 intact:EBI-355530|uniprotkb:Q6PJ85|uniprotkb:Q6PK85|uniprotkb:Q6PKA2|uniprotkb:Q86XI3|uniprotkb:Q8NDR5|uniprotkb:Q96I86|uniprotkb:Q9H6J9|uniprotkb:Q9H288|ensembl:ENSP00000351416|uniprotkb:G5E964|uniprotkb:E7EUV3 psi-mi:bap1_human(display_long)|uniprotkb:BAP1(gene name)|psi-mi:BAP1(display_short)|uniprotkb:KIAA0272(gene name synonym)|uniprotkb:hucep-6(orf name)|uniprotkb:BRCA1-associated protein 1(gene name synonym)|uniprotkb:Cerebral protein 6(gene name synonym) psi-mi:anr17_human(display_long)|uniprotkb:ANKRD17(gene name)|psi-mi:ANKRD17(display_short)|uniprotkb:GTAR(gene name synonym)|uniprotkb:KIAA0697(gene name synonym)|uniprotkb:Gene trap ankyrin repeat protein(gene name synonym)|uniprotkb:Serologically defined breast cancer antigen NY-BR-16(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2509989|imex:IM-12079-53 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-47004N|refseq:NP_004647.1|ensembl:ENSG00000163930(gene)|ensembl:ENST00000460680(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0003682"(chromatin binding)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008233"(peptidase activity)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010035"(response to inorganic substance)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035517"(PR-DUB complex)|go:"GO:0035520"(monoubiquitinated protein deubiquitination)|go:"GO:0035522"(monoubiquitinated histone H2A deubiquitination)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0061519"(macrophage homeostasis)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:1900015"(regulation of cytokine production involved in inflammatory response)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|interpro:IPR001578(Peptidase C12, ubiquitin carboxyl-terminal hydrolase 1)|interpro:IPR036959|interpro:IPR038765|interpro:IPR041507|mint:Q92560|reactome:R-HSA-5689603|reactome:R-HSA-5693565 refseq:NP_115593.3|refseq:NP_942592.1|refseq:NP_056389.1|ensembl:ENSG00000132466(gene)|ensembl:ENST00000358602(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0001955"(blood vessel maturation)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0016020"(membrane)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045087"(innate immune response)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0051151"(negative regulation of smooth muscle cell differentiation)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1900245"(positive regulation of MDA-5 signaling pathway)|go:"GO:1900246"(positive regulation of RIG-I signaling pathway)|interpro:IPR002110(Ankyrin)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR020683|interpro:IPR036612|interpro:IPR036770|mint:O75179|go:"GO:0031965"(nuclear membrane)|refseq:NP_001273700.1|ensembl:ENST00000330838|ensembl:ENSP00000332265|ensembl:ENSP00000351416|ensembl:ENST00000509867|ensembl:ENSP00000427151|dip:DIP-47290N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:GMWdT1u5HUl29N+YgC/bCKTbxm49606 rogid:l/gkMCasWF6pn6feuIzeQKWwwKM9606 intact-crc:89E9AB79EFAE28D6|rigid:V6jURcKZ46ct04Ne1KJYfQojUX4 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q92560 uniprotkb:Q9UJX3 intact:EBI-1791447|uniprotkb:Q6LEM0|uniprotkb:Q7Z5E8|uniprotkb:A8K993|intact:EBI-2558090|ensembl:ENSP00000417132 intact:EBI-1384164|uniprotkb:Q96AC4|uniprotkb:Q96GF4|uniprotkb:Q9BU24|uniprotkb:Q9NT16|ensembl:ENSP00000394394|ensembl:ENSP00000402314 psi-mi:bap1_human(display_long)|uniprotkb:BAP1(gene name)|psi-mi:BAP1(display_short)|uniprotkb:KIAA0272(gene name synonym)|uniprotkb:hucep-6(orf name)|uniprotkb:BRCA1-associated protein 1(gene name synonym)|uniprotkb:Cerebral protein 6(gene name synonym) psi-mi:apc7_human(display_long)|uniprotkb:ANAPC7(gene name)|psi-mi:ANAPC7(display_short)|uniprotkb:APC7(gene name synonym)|uniprotkb:Cyclosome subunit 7(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2509989|imex:IM-12079-53 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-47004N|refseq:NP_004647.1|ensembl:ENSG00000163930(gene)|ensembl:ENST00000460680(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0003682"(chromatin binding)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008233"(peptidase activity)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010035"(response to inorganic substance)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035517"(PR-DUB complex)|go:"GO:0035520"(monoubiquitinated protein deubiquitination)|go:"GO:0035522"(monoubiquitinated histone H2A deubiquitination)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0061519"(macrophage homeostasis)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:1900015"(regulation of cytokine production involved in inflammatory response)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|interpro:IPR001578(Peptidase C12, ubiquitin carboxyl-terminal hydrolase 1)|interpro:IPR036959|interpro:IPR038765|interpro:IPR041507|mint:Q92560|reactome:R-HSA-5689603|reactome:R-HSA-5693565 refseq:NP_001131136.1|refseq:NP_057322.2|dip:DIP-39765N|ensembl:ENSG00000196510(gene)|ensembl:ENST00000450008(transcript)|ensembl:ENST00000455511(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005680"(anaphase-promoting complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0007091"(metaphase/anaphase transition of mitotic cell cycle)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0031145"(anaphase-promoting complex-dependent catabolic process)|go:"GO:0045842"(positive regulation of mitotic metaphase/anaphase transition)|go:"GO:0051301"(cell division)|go:"GO:0070979"(protein K11-linked ubiquitination)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|mint:Q9UJX3|rcsb pdb:3FFL|rcsb pdb:4UI9|rcsb pdb:5A31|rcsb pdb:5G04|rcsb pdb:5G05|rcsb pdb:5KHR|rcsb pdb:5KHU|rcsb pdb:5L9T|rcsb pdb:5L9U|rcsb pdb:5LCW|rcsb pdb:6Q6G|rcsb pdb:6Q6H|rcsb pdb:6TLJ|rcsb pdb:6TM5|rcsb pdb:6TNT|reactome:R-HSA-141430|reactome:R-HSA-174048|reactome:R-HSA-174084|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-176407|reactome:R-HSA-176408|reactome:R-HSA-176409|reactome:R-HSA-176412|reactome:R-HSA-179409|reactome:R-HSA-2467813|reactome:R-HSA-2559582|reactome:R-HSA-69017|reactome:R-HSA-8853884|reactome:R-HSA-9687136|reactome:R-HSA-983168 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:GMWdT1u5HUl29N+YgC/bCKTbxm49606 rogid:2q+llvuIzK2MOWjPuOUxmyN782E9606 intact-crc:89E9AB79EFAE28D6|rigid:V6jURcKZ46ct04Ne1KJYfQojUX4 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q92560 uniprotkb:P83916 intact:EBI-1791447|uniprotkb:Q6LEM0|uniprotkb:Q7Z5E8|uniprotkb:A8K993|intact:EBI-2558090|ensembl:ENSP00000417132 intact:EBI-78129|uniprotkb:P23197|ensembl:ENSP00000225603|ensembl:ENSP00000377060 psi-mi:bap1_human(display_long)|uniprotkb:BAP1(gene name)|psi-mi:BAP1(display_short)|uniprotkb:KIAA0272(gene name synonym)|uniprotkb:hucep-6(orf name)|uniprotkb:BRCA1-associated protein 1(gene name synonym)|uniprotkb:Cerebral protein 6(gene name synonym) psi-mi:cbx1_human(display_long)|uniprotkb:CBX1(gene name)|psi-mi:CBX1(display_short)|uniprotkb:CBX(gene name synonym)|uniprotkb:Heterochromatin protein 1 homolog beta(gene name synonym)|uniprotkb:Modifier 1 protein(gene name synonym)|uniprotkb:M31(gene name synonym)|uniprotkb:Heterochromatin protein p25(gene name synonym)|uniprotkb:p25beta(gene name synonym)|uniprotkb:HP1Hsbeta(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2509989|imex:IM-12079-53 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-47004N|refseq:NP_004647.1|ensembl:ENSG00000163930(gene)|ensembl:ENST00000460680(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0003682"(chromatin binding)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008233"(peptidase activity)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010035"(response to inorganic substance)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035517"(PR-DUB complex)|go:"GO:0035520"(monoubiquitinated protein deubiquitination)|go:"GO:0035522"(monoubiquitinated histone H2A deubiquitination)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0061519"(macrophage homeostasis)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:1900015"(regulation of cytokine production involved in inflammatory response)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|interpro:IPR001578(Peptidase C12, ubiquitin carboxyl-terminal hydrolase 1)|interpro:IPR036959|interpro:IPR038765|interpro:IPR041507|mint:Q92560|reactome:R-HSA-5689603|reactome:R-HSA-5693565 ensembl:ENSG00000108468(gene)|ensembl:ENST00000225603(transcript)|ensembl:ENST00000393408(transcript)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0001939"(female pronucleus)|go:"GO:0001940"(male pronucleus)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0005819"(spindle)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010369"(chromocenter)|go:"GO:0019899"(enzyme binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0090734"(site of DNA damage)|go:"GO:1990226"(histone methyltransferase binding)|interpro:IPR000953(Chromo domain)|interpro:IPR008251(Chromo shadow)|interpro:IPR016197(Chromo domain-like)|interpro:IPR017984|interpro:IPR023779|interpro:IPR023780|mint:P83916|rcsb pdb:2FMM|rcsb pdb:3F2U|rcsb pdb:3Q6S|rcsb pdb:5T1G|rcsb pdb:6D07|rcsb pdb:6D08|reactome:R-HSA-9609690|refseq:NP_001120700.1|refseq:NP_006798.1|dip:DIP-28135N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:GMWdT1u5HUl29N+YgC/bCKTbxm49606 rogid:W2npW/vFRcuTkStKpknsAP69q6I9606 intact-crc:89E9AB79EFAE28D6|rigid:V6jURcKZ46ct04Ne1KJYfQojUX4 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q92560 uniprotkb:O15355 intact:EBI-1791447|uniprotkb:Q6LEM0|uniprotkb:Q7Z5E8|uniprotkb:A8K993|intact:EBI-2558090|ensembl:ENSP00000417132 intact:EBI-725702|ensembl:ENSP00000342778 psi-mi:bap1_human(display_long)|uniprotkb:BAP1(gene name)|psi-mi:BAP1(display_short)|uniprotkb:KIAA0272(gene name synonym)|uniprotkb:hucep-6(orf name)|uniprotkb:BRCA1-associated protein 1(gene name synonym)|uniprotkb:Cerebral protein 6(gene name synonym) psi-mi:ppm1g_human(display_long)|uniprotkb:Protein phosphatase 2C isoform gamma(gene name synonym)|uniprotkb:Protein phosphatase magnesium-dependent 1 gamma(gene name synonym)|uniprotkb:Protein phosphatase 1C(gene name synonym)|uniprotkb:PPM1G(gene name)|psi-mi:PPM1G(display_short)|uniprotkb:PPM1C(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2509989|imex:IM-12079-53 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-47004N|refseq:NP_004647.1|ensembl:ENSG00000163930(gene)|ensembl:ENST00000460680(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0003682"(chromatin binding)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008233"(peptidase activity)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010035"(response to inorganic substance)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035517"(PR-DUB complex)|go:"GO:0035520"(monoubiquitinated protein deubiquitination)|go:"GO:0035522"(monoubiquitinated histone H2A deubiquitination)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0061519"(macrophage homeostasis)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:1900015"(regulation of cytokine production involved in inflammatory response)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|interpro:IPR001578(Peptidase C12, ubiquitin carboxyl-terminal hydrolase 1)|interpro:IPR036959|interpro:IPR038765|interpro:IPR041507|mint:Q92560|reactome:R-HSA-5689603|reactome:R-HSA-5693565 refseq:NP_817092.1|ensembl:ENST00000344034(transcript)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006470"(protein dephosphorylation)|ensembl:ENSG00000115241(gene)|go:"GO:0016020"(membrane)|go:"GO:0035970"(peptidyl-threonine dephosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0106306"|go:"GO:0106307"|interpro:IPR000222(Protein phosphatase 2C, manganese/magnesium aspartate binding site)|interpro:IPR001932(Protein phosphatase 2C-related)|interpro:IPR015655(Protein phosphatase 2C)|interpro:IPR036457|mint:O15355|dip:DIP-29404N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:GMWdT1u5HUl29N+YgC/bCKTbxm49606 rogid:j9ut2f7QHVyOtsLuYJ8e2XOP3HE9606 intact-crc:89E9AB79EFAE28D6|rigid:V6jURcKZ46ct04Ne1KJYfQojUX4 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q92560 uniprotkb:Q96HN2 intact:EBI-1791447|uniprotkb:Q6LEM0|uniprotkb:Q7Z5E8|uniprotkb:A8K993|intact:EBI-2558090|ensembl:ENSP00000417132 intact:EBI-1056923|uniprotkb:O94917|uniprotkb:B4DIZ5|uniprotkb:D9N155|ensembl:ENSP00000315931 psi-mi:bap1_human(display_long)|uniprotkb:BAP1(gene name)|psi-mi:BAP1(display_short)|uniprotkb:KIAA0272(gene name synonym)|uniprotkb:hucep-6(orf name)|uniprotkb:BRCA1-associated protein 1(gene name synonym)|uniprotkb:Cerebral protein 6(gene name synonym) psi-mi:sahh3_human(display_long)|uniprotkb:AHCYL2(gene name)|psi-mi:AHCYL2(display_short)|uniprotkb:KIAA0828(gene name synonym)|uniprotkb:S-adenosyl-L-homocysteine hydrolase 3(gene name synonym)|uniprotkb:S-adenosylhomocysteine hydrolase-like protein 2(gene name synonym)|uniprotkb:"IP(3)Rs binding protein released with IP(3) 2"(gene name synonym)|uniprotkb:Long-IRBIT(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2509989|imex:IM-12079-53 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-47004N|refseq:NP_004647.1|ensembl:ENSG00000163930(gene)|ensembl:ENST00000460680(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0003682"(chromatin binding)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008233"(peptidase activity)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010035"(response to inorganic substance)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035517"(PR-DUB complex)|go:"GO:0035520"(monoubiquitinated protein deubiquitination)|go:"GO:0035522"(monoubiquitinated histone H2A deubiquitination)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0061519"(macrophage homeostasis)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:1900015"(regulation of cytokine production involved in inflammatory response)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|interpro:IPR001578(Peptidase C12, ubiquitin carboxyl-terminal hydrolase 1)|interpro:IPR036959|interpro:IPR038765|interpro:IPR041507|mint:Q92560|reactome:R-HSA-5689603|reactome:R-HSA-5693565 refseq:NP_001124192.1|refseq:NP_001124194.2|refseq:NP_001124195.1|refseq:NP_056143.1|ensembl:ENSG00000158467(gene)|ensembl:ENST00000325006(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006730"(one-carbon metabolic process)|go:"GO:0016787"(hydrolase activity)|go:"GO:0033353"(S-adenosylmethionine cycle)|go:"GO:0043005"(neuron projection)|interpro:IPR000043(S-adenosyl-L-homocysteine hydrolase)|interpro:IPR015878(S-adenosyl-L-homocysteine hydrolase, NAD binding)|interpro:IPR020082|interpro:IPR036291|interpro:IPR042172|rcsb pdb:3GVP|reactome:R-HSA-425381 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:GMWdT1u5HUl29N+YgC/bCKTbxm49606 rogid:OOrDmlSeGOWqnAhYQcNa4tF5pk09606 intact-crc:89E9AB79EFAE28D6|rigid:V6jURcKZ46ct04Ne1KJYfQojUX4 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P46736 uniprotkb:Q15018 intact:EBI-750352|uniprotkb:Q16107|uniprotkb:Q9BTZ6|uniprotkb:A6QRF8|uniprotkb:A6QRF9|uniprotkb:A8MUX5|uniprotkb:A8MWH0|uniprotkb:A9Z1Y0|uniprotkb:A9Z1Y5|uniprotkb:B1B062|uniprotkb:B4DQN7|uniprotkb:Q53YX5|ensembl:ENSP00000358474 intact:EBI-1056583|uniprotkb:Q96H11|uniprotkb:B4DKR2|intact:EBI-28981592|ensembl:ENSP00000298492 psi-mi:brcc3_human(display_long)|uniprotkb:BRCC3(gene name)|psi-mi:BRCC3(display_short)|uniprotkb:C6.1A(gene name synonym)|uniprotkb:CXorf53(gene name synonym)|uniprotkb:BRCC36(gene name synonym)|uniprotkb:BRCA1-A complex subunit BRCC36(gene name synonym)|uniprotkb:BRISC complex subunit BRCC36(gene name synonym)|uniprotkb:BRCA1/BRCA2-containing complex subunit 3(gene name synonym)|uniprotkb:BRCA1/BRCA2-containing complex subunit 36(gene name synonym) psi-mi:abrx2_human(display_long)|uniprotkb:ABRAXAS2(gene name)|psi-mi:ABRAXAS2(display_short)|uniprotkb:ABRO1(gene name synonym)|uniprotkb:Abraxas brother protein 1(gene name synonym)|uniprotkb:FAM175B(gene name synonym)|uniprotkb:KIAA0157(gene name synonym)|uniprotkb:Protein FAM175B(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510058|imex:IM-12079-2 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001018065.1|refseq:NP_001229569.1|refseq:NP_077308.1|refseq:XP_016885327.1|dip:DIP-48719N|ensembl:ENSG00000185515(gene)|go:"GO:0000152"(nuclear ubiquitin ligase complex)|go:"GO:0000922"(spindle pole)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0010165"(response to X-ray)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0046872"(metal ion binding)|go:"GO:0051301"(cell division)|go:"GO:0061578"(Lys63-specific deubiquitinase activity)|go:"GO:0070122"(isopeptidase activity)|ensembl:ENST00000369462(transcript)|go:"GO:0070531"(BRCA1-A complex)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0070537"(histone H2A K63-linked deubiquitination)|go:"GO:0070552"(BRISC complex)|go:"GO:0000151"(ubiquitin ligase complex)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR033860|interpro:IPR037518|interpro:IPR040749|mint:P46736|rcsb pdb:6H3C|rcsb pdb:6R8F|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473 ensembl:ENSP00000298492|refseq:NP_115558.3|ensembl:ENSG00000165660(gene)|ensembl:ENST00000298492(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000922"(spindle pole)|go:"GO:0002931"(response to ischemia)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0007059"(chromosome segregation)|go:"GO:0008017"(microtubule binding)|go:"GO:0008608"(attachment of spindle microtubules to kinetochore)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0051301"(cell division)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0070552"(BRISC complex)|go:"GO:0090307"(mitotic spindle assembly)|interpro:IPR023238|interpro:IPR023240|interpro:IPR037518|mint:Q15018|rcsb pdb:6H3C|rcsb pdb:6R8F|reactome:R-HSA-5689901 psi-mi:"MI:0469"(intact) caution:This sequence has been withdrawn from Uniprot.|crc64:5720358C1A2F7421 - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/11/01 rogid:4YP0TYSnZOZQ4mFEmr07XIx+AVw9606 rogid:fYZdQpH09qcBBUV1IKV2wsRk4m89606 intact-crc:75875F79320A0255|rigid:rxKFzekBdg4rGYdf1R4LzTy+A9U false flag tag:n-n|ha tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P46736 uniprotkb:Q86VP6 intact:EBI-750352|uniprotkb:Q16107|uniprotkb:Q9BTZ6|uniprotkb:A6QRF8|uniprotkb:A6QRF9|uniprotkb:A8MUX5|uniprotkb:A8MWH0|uniprotkb:A9Z1Y0|uniprotkb:A9Z1Y5|uniprotkb:B1B062|uniprotkb:B4DQN7|uniprotkb:Q53YX5|ensembl:ENSP00000358474 intact:EBI-456077|uniprotkb:O94918|uniprotkb:Q6PIY4|uniprotkb:Q8NDJ4|uniprotkb:Q96JZ9|uniprotkb:Q96T19|uniprotkb:Q9BTC4|uniprotkb:Q9H0G2|uniprotkb:Q9P0H7|uniprotkb:Q9UF85|uniprotkb:B2RAU3|ensembl:ENSP00000442318 psi-mi:brcc3_human(display_long)|uniprotkb:BRCC3(gene name)|psi-mi:BRCC3(display_short)|uniprotkb:C6.1A(gene name synonym)|uniprotkb:CXorf53(gene name synonym)|uniprotkb:BRCC36(gene name synonym)|uniprotkb:BRCA1-A complex subunit BRCC36(gene name synonym)|uniprotkb:BRISC complex subunit BRCC36(gene name synonym)|uniprotkb:BRCA1/BRCA2-containing complex subunit 3(gene name synonym)|uniprotkb:BRCA1/BRCA2-containing complex subunit 36(gene name synonym) psi-mi:cand1_human(display_long)|uniprotkb:KIAA0829(gene name synonym)|uniprotkb:TIP120(gene name synonym)|uniprotkb:TIP120A(gene name synonym)|uniprotkb:Cullin-associated and neddylation-dissociated protein 1(gene name synonym)|uniprotkb:p120 CAND1(gene name synonym)|uniprotkb:TBP-interacting protein of 120 kDa A(gene name synonym)|uniprotkb:CAND1(gene name)|psi-mi:CAND1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510058|imex:IM-12079-2 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001018065.1|refseq:NP_001229569.1|refseq:NP_077308.1|refseq:XP_016885327.1|dip:DIP-48719N|ensembl:ENSG00000185515(gene)|go:"GO:0000152"(nuclear ubiquitin ligase complex)|go:"GO:0000922"(spindle pole)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0010165"(response to X-ray)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0046872"(metal ion binding)|go:"GO:0051301"(cell division)|go:"GO:0061578"(Lys63-specific deubiquitinase activity)|go:"GO:0070122"(isopeptidase activity)|ensembl:ENST00000369462(transcript)|go:"GO:0070531"(BRCA1-A complex)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0070537"(histone H2A K63-linked deubiquitination)|go:"GO:0070552"(BRISC complex)|go:"GO:0000151"(ubiquitin ligase complex)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR033860|interpro:IPR037518|interpro:IPR040749|mint:P46736|rcsb pdb:6H3C|rcsb pdb:6R8F|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473 refseq:NP_060918.2|dip:DIP-31608N|ensembl:ENSG00000111530(gene)|ensembl:ENST00000545606(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0010265"(SCF complex assembly)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0017025"(TBP-class protein binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0045899"(positive regulation of RNA polymerase II transcription preinitiation complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR013932("TATA-binding protein interacting (TIP20)")|interpro:IPR039852|mint:Q86VP6|rcsb pdb:1U6G|rcsb pdb:4A0C|reactome:R-HSA-6798695|reactome:R-HSA-8951664|reactome:R-HSA-917937|interpro:IPR016024(Armadillo-type fold) psi-mi:"MI:0469"(intact) caution:This sequence has been withdrawn from Uniprot.|crc64:5720358C1A2F7421 - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/11/01 rogid:4YP0TYSnZOZQ4mFEmr07XIx+AVw9606 rogid:2lBY8xJXlGZL+xyo/dyB2WzuNqs9606 intact-crc:75875F79320A0255|rigid:rxKFzekBdg4rGYdf1R4LzTy+A9U false flag tag:n-n|ha tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P46736 uniprotkb:P34897 intact:EBI-750352|uniprotkb:Q16107|uniprotkb:Q9BTZ6|uniprotkb:A6QRF8|uniprotkb:A6QRF9|uniprotkb:A8MUX5|uniprotkb:A8MWH0|uniprotkb:A9Z1Y0|uniprotkb:A9Z1Y5|uniprotkb:B1B062|uniprotkb:B4DQN7|uniprotkb:Q53YX5|ensembl:ENSP00000358474 intact:EBI-352908|ensembl:ENSP00000333667|uniprotkb:O00740|uniprotkb:Q8N1A5|uniprotkb:B7Z9F1|uniprotkb:E7EQ19|uniprotkb:E7EU43 psi-mi:brcc3_human(display_long)|uniprotkb:BRCC3(gene name)|psi-mi:BRCC3(display_short)|uniprotkb:C6.1A(gene name synonym)|uniprotkb:CXorf53(gene name synonym)|uniprotkb:BRCC36(gene name synonym)|uniprotkb:BRCA1-A complex subunit BRCC36(gene name synonym)|uniprotkb:BRISC complex subunit BRCC36(gene name synonym)|uniprotkb:BRCA1/BRCA2-containing complex subunit 3(gene name synonym)|uniprotkb:BRCA1/BRCA2-containing complex subunit 36(gene name synonym) psi-mi:glym_human(display_long)|uniprotkb:SHMT2(gene name)|psi-mi:SHMT2(display_short)|uniprotkb:Glycine hydroxymethyltransferase(gene name synonym)|uniprotkb:Serine methylase(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510058|imex:IM-12079-2 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001018065.1|refseq:NP_001229569.1|refseq:NP_077308.1|refseq:XP_016885327.1|dip:DIP-48719N|ensembl:ENSG00000185515(gene)|go:"GO:0000152"(nuclear ubiquitin ligase complex)|go:"GO:0000922"(spindle pole)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0010165"(response to X-ray)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0046872"(metal ion binding)|go:"GO:0051301"(cell division)|go:"GO:0061578"(Lys63-specific deubiquitinase activity)|go:"GO:0070122"(isopeptidase activity)|ensembl:ENST00000369462(transcript)|go:"GO:0070531"(BRCA1-A complex)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0070537"(histone H2A K63-linked deubiquitination)|go:"GO:0070552"(BRISC complex)|go:"GO:0000151"(ubiquitin ligase complex)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR033860|interpro:IPR037518|interpro:IPR040749|mint:P46736|rcsb pdb:6H3C|rcsb pdb:6R8F|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473 ensembl:ENSG00000182199(gene)|ensembl:ENST00000328923(transcript)|go:"GO:0000900"(translation repressor activity, mRNA regulatory element binding)|go:"GO:0002082"(regulation of oxidative phosphorylation)|go:"GO:0003682"(chromatin binding)|go:"GO:0004372"(glycine hydroxymethyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006544"(glycine metabolic process)|go:"GO:0006563"(L-serine metabolic process)|go:"GO:0006564"(L-serine biosynthetic process)|go:"GO:0006565"(L-serine catabolic process)|go:"GO:0006730"(one-carbon metabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008732"(L-allo-threonine aldolase activity)|go:"GO:0009113"(purine nucleobase biosynthetic process)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0019264"(glycine biosynthetic process from serine)|go:"GO:0030170"(pyridoxal phosphate binding)|go:"GO:0034340"(response to type I interferon)|go:"GO:0035999"(tetrahydrofolate interconversion)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046653"(tetrahydrofolate metabolic process)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0050897"(cobalt ion binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070129"(regulation of mitochondrial translation)|go:"GO:0046655"(folic acid metabolic process)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0070552"(BRISC complex)|go:"GO:0070905"(serine binding)|go:"GO:1903715"(regulation of aerobic respiration)|interpro:IPR001085(Glycine hydroxymethyltransferase)|interpro:IPR015421(Pyridoxal phosphate-dependent transferase, major region, subdomain 1)|interpro:IPR015422(Pyridoxal phosphate-dependent transferase, major region, subdomain 2)|interpro:IPR015424(Pyridoxal phosphate-dependent transferase, major region)|interpro:IPR019798|interpro:IPR039429|mint:P34897|rcsb pdb:4PVF|rcsb pdb:5V7I|rcsb pdb:5X3V|rcsb pdb:6DK3|rcsb pdb:6H3C|rcsb pdb:6M5O|rcsb pdb:6QVG|rcsb pdb:6QVL|rcsb pdb:6R8F|reactome:R-HSA-196757|reactome:R-HSA-9013408|refseq:NP_001159829.1|refseq:NP_001159830.1|refseq:NP_001159831.1|refseq:NP_005403.2|refseq:NP_001159828.1 psi-mi:"MI:0469"(intact) caution:This sequence has been withdrawn from Uniprot.|crc64:5720358C1A2F7421 - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/11/01 rogid:4YP0TYSnZOZQ4mFEmr07XIx+AVw9606 rogid:Ce7izVDbUDULaGUe2fZWlikUZFk9606 intact-crc:75875F79320A0255|rigid:rxKFzekBdg4rGYdf1R4LzTy+A9U false flag tag:n-n|ha tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P46736 uniprotkb:Q8IYI6 intact:EBI-750352|uniprotkb:Q16107|uniprotkb:Q9BTZ6|uniprotkb:A6QRF8|uniprotkb:A6QRF9|uniprotkb:A8MUX5|uniprotkb:A8MWH0|uniprotkb:A9Z1Y0|uniprotkb:A9Z1Y5|uniprotkb:B1B062|uniprotkb:B4DQN7|uniprotkb:Q53YX5|ensembl:ENSP00000358474 intact:EBI-742102|ensembl:ENSP00000355605|uniprotkb:Q5TE82|uniprotkb:B3KU33 psi-mi:brcc3_human(display_long)|uniprotkb:BRCC3(gene name)|psi-mi:BRCC3(display_short)|uniprotkb:C6.1A(gene name synonym)|uniprotkb:CXorf53(gene name synonym)|uniprotkb:BRCC36(gene name synonym)|uniprotkb:BRCA1-A complex subunit BRCC36(gene name synonym)|uniprotkb:BRISC complex subunit BRCC36(gene name synonym)|uniprotkb:BRCA1/BRCA2-containing complex subunit 3(gene name synonym)|uniprotkb:BRCA1/BRCA2-containing complex subunit 36(gene name synonym) psi-mi:exoc8_human(display_long)|uniprotkb:Exocyst complex 84 kDa subunit(gene name synonym)|uniprotkb:EXOC8(gene name)|psi-mi:EXOC8(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510058|imex:IM-12079-2 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001018065.1|refseq:NP_001229569.1|refseq:NP_077308.1|refseq:XP_016885327.1|dip:DIP-48719N|ensembl:ENSG00000185515(gene)|go:"GO:0000152"(nuclear ubiquitin ligase complex)|go:"GO:0000922"(spindle pole)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0010165"(response to X-ray)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0046872"(metal ion binding)|go:"GO:0051301"(cell division)|go:"GO:0061578"(Lys63-specific deubiquitinase activity)|go:"GO:0070122"(isopeptidase activity)|ensembl:ENST00000369462(transcript)|go:"GO:0070531"(BRCA1-A complex)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0070537"(histone H2A K63-linked deubiquitination)|go:"GO:0070552"(BRISC complex)|go:"GO:0000151"(ubiquitin ligase complex)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR033860|interpro:IPR037518|interpro:IPR040749|mint:P46736|rcsb pdb:6H3C|rcsb pdb:6R8F|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473 go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006887"(exocytosis)|go:"GO:0006893"(Golgi to plasma membrane transport)|go:"GO:0007032"(endosome organization)|go:"GO:0008104"(protein localization)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0030426"(growth cone)|ensembl:ENSG00000116903(gene)|go:"GO:0031252"(cell leading edge)|ensembl:ENST00000366645(transcript)|go:"GO:0000145"(exocyst)|go:"GO:0005770"(late endosome)|go:"GO:0031267"(small GTPase binding)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|refseq:NP_787072.2|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016159(Cullin repeat-like)|interpro:IPR032403|interpro:IPR033961|interpro:IPR042560|interpro:IPR042561|reactome:R-HSA-1445148|reactome:R-HSA-264876|reactome:R-HSA-5620916 psi-mi:"MI:0469"(intact) caution:This sequence has been withdrawn from Uniprot.|crc64:5720358C1A2F7421 - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/11/01 rogid:4YP0TYSnZOZQ4mFEmr07XIx+AVw9606 rogid:VXQFBw3zltr9eQ/3EgdLszUZbbs9606 intact-crc:75875F79320A0255|rigid:rxKFzekBdg4rGYdf1R4LzTy+A9U false flag tag:n-n|ha tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P46736 uniprotkb:Q6UWZ7 intact:EBI-750352|uniprotkb:Q16107|uniprotkb:Q9BTZ6|uniprotkb:A6QRF8|uniprotkb:A6QRF9|uniprotkb:A8MUX5|uniprotkb:A8MWH0|uniprotkb:A9Z1Y0|uniprotkb:A9Z1Y5|uniprotkb:B1B062|uniprotkb:B4DQN7|uniprotkb:Q53YX5|ensembl:ENSP00000358474 intact:EBI-1263451|uniprotkb:Q9H8I1|uniprotkb:Q9H9N4|uniprotkb:A5JJ07|ensembl:ENSP00000369857 psi-mi:brcc3_human(display_long)|uniprotkb:BRCC3(gene name)|psi-mi:BRCC3(display_short)|uniprotkb:C6.1A(gene name synonym)|uniprotkb:CXorf53(gene name synonym)|uniprotkb:BRCC36(gene name synonym)|uniprotkb:BRCA1-A complex subunit BRCC36(gene name synonym)|uniprotkb:BRISC complex subunit BRCC36(gene name synonym)|uniprotkb:BRCA1/BRCA2-containing complex subunit 3(gene name synonym)|uniprotkb:BRCA1/BRCA2-containing complex subunit 36(gene name synonym) psi-mi:abrx1_human(display_long)|uniprotkb:ABRAXAS1(gene name)|psi-mi:ABRAXAS1(display_short)|uniprotkb:ABRA1(gene name synonym)|uniprotkb:CCDC98(gene name synonym)|uniprotkb:Coiled-coil domain-containing protein 98(gene name synonym)|uniprotkb:FAM175A(gene name synonym)|uniprotkb:Protein FAM175A(gene name synonym)|uniprotkb:UNQ496/PRO1013(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510058|imex:IM-12079-2 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001018065.1|refseq:NP_001229569.1|refseq:NP_077308.1|refseq:XP_016885327.1|dip:DIP-48719N|ensembl:ENSG00000185515(gene)|go:"GO:0000152"(nuclear ubiquitin ligase complex)|go:"GO:0000922"(spindle pole)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0010165"(response to X-ray)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0046872"(metal ion binding)|go:"GO:0051301"(cell division)|go:"GO:0061578"(Lys63-specific deubiquitinase activity)|go:"GO:0070122"(isopeptidase activity)|ensembl:ENST00000369462(transcript)|go:"GO:0070531"(BRCA1-A complex)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0070537"(histone H2A K63-linked deubiquitination)|go:"GO:0070552"(BRISC complex)|go:"GO:0000151"(ubiquitin ligase complex)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR033860|interpro:IPR037518|interpro:IPR040749|mint:P46736|rcsb pdb:6H3C|rcsb pdb:6R8F|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473 dip:DIP-29615N|refseq:NP_620775.2|refseq:NP_001332891.1|ensembl:ENSG00000163322(gene)|ensembl:ENST00000321945(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006325"(chromatin organization)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0008017"(microtubule binding)|go:"GO:0008608"(attachment of spindle microtubules to kinetochore)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016604"(nuclear body)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0070531"(BRCA1-A complex)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0090307"(mitotic spindle assembly)|interpro:IPR023238|interpro:IPR023239|interpro:IPR037518|rcsb pdb:4JLU|rcsb pdb:4U4A|rcsb pdb:4Y18|rcsb pdb:4Y2G|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473 psi-mi:"MI:0469"(intact) caution:This sequence has been withdrawn from Uniprot.|crc64:5720358C1A2F7421 caution:This sequence has been withdrawn from Uniprot. figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/11/01 rogid:4YP0TYSnZOZQ4mFEmr07XIx+AVw9606 rogid:ZD7wQnqzfRv9owR8/zdgrMP5W6c9606 intact-crc:75875F79320A0255|rigid:rxKFzekBdg4rGYdf1R4LzTy+A9U false flag tag:n-n|ha tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P46736 uniprotkb:Q96RL1 intact:EBI-750352|uniprotkb:Q16107|uniprotkb:Q9BTZ6|uniprotkb:A6QRF8|uniprotkb:A6QRF9|uniprotkb:A8MUX5|uniprotkb:A8MWH0|uniprotkb:A9Z1Y0|uniprotkb:A9Z1Y5|uniprotkb:B1B062|uniprotkb:B4DQN7|uniprotkb:Q53YX5|ensembl:ENSP00000358474 intact:EBI-725300|intact:EBI-1263554|uniprotkb:Q5XKQ1|uniprotkb:Q7Z3W7|uniprotkb:Q8N5B9|uniprotkb:Q9BZR1|uniprotkb:Q9BZR5|uniprotkb:Q9UHX7|uniprotkb:A8MSA1|uniprotkb:B3KMZ1|uniprotkb:B4E3N2|ensembl:ENSP00000366434|ensembl:ENSP00000421926 psi-mi:brcc3_human(display_long)|uniprotkb:BRCC3(gene name)|psi-mi:BRCC3(display_short)|uniprotkb:C6.1A(gene name synonym)|uniprotkb:CXorf53(gene name synonym)|uniprotkb:BRCC36(gene name synonym)|uniprotkb:BRCA1-A complex subunit BRCC36(gene name synonym)|uniprotkb:BRISC complex subunit BRCC36(gene name synonym)|uniprotkb:BRCA1/BRCA2-containing complex subunit 3(gene name synonym)|uniprotkb:BRCA1/BRCA2-containing complex subunit 36(gene name synonym) psi-mi:uimc1_human(display_long)|uniprotkb:Retinoid X receptor-interacting protein 110(gene name synonym)|uniprotkb:Receptor-associated protein 80(gene name synonym)|uniprotkb:Ubiquitin interaction motif-containing protein 1(gene name synonym)|uniprotkb:UIMC1(gene name)|psi-mi:UIMC1(display_short)|uniprotkb:RAP80(gene name synonym)|uniprotkb:RXRIP110(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510058|imex:IM-12079-2 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001018065.1|refseq:NP_001229569.1|refseq:NP_077308.1|refseq:XP_016885327.1|dip:DIP-48719N|ensembl:ENSG00000185515(gene)|go:"GO:0000152"(nuclear ubiquitin ligase complex)|go:"GO:0000922"(spindle pole)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0010165"(response to X-ray)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0046872"(metal ion binding)|go:"GO:0051301"(cell division)|go:"GO:0061578"(Lys63-specific deubiquitinase activity)|go:"GO:0070122"(isopeptidase activity)|ensembl:ENST00000369462(transcript)|go:"GO:0070531"(BRCA1-A complex)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0070537"(histone H2A K63-linked deubiquitination)|go:"GO:0070552"(BRISC complex)|go:"GO:0000151"(ubiquitin ligase complex)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR033860|interpro:IPR037518|interpro:IPR040749|mint:P46736|rcsb pdb:6H3C|rcsb pdb:6R8F|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473 refseq:NP_001186226.1|refseq:NP_001186227.1|refseq:NP_057374.3|refseq:NP_001304890.1|ensembl:ENSG00000087206(gene)|ensembl:ENST00000377227(transcript)|ensembl:ENST00000511320(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006302"(double-strand break repair)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016604"(nuclear body)|go:"GO:0042393"(histone binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0070531"(BRCA1-A complex)|go:"GO:0070537"(histone H2A K63-linked deubiquitination)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR006642(Zinc finger, Rad18-type putative)|interpro:IPR038868|interpro:IPR040714|mint:Q96RL1|rcsb pdb:2MKF|rcsb pdb:2MKG|rcsb pdb:2N9E|rcsb pdb:2RR9|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473|refseq:XP_005265987.1|refseq:XP_005265993.1|refseq:XP_006714934.1|refseq:XP_016865063.1|refseq:XP_016865067.1|refseq:XP_016865068.1|dip:DIP-29936N psi-mi:"MI:0469"(intact) caution:This sequence has been withdrawn from Uniprot.|crc64:5720358C1A2F7421 - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/11/01 rogid:4YP0TYSnZOZQ4mFEmr07XIx+AVw9606 rogid:j5ho+aD4tkX7bXXlROdiprUX1Mc9606 intact-crc:75875F79320A0255|rigid:rxKFzekBdg4rGYdf1R4LzTy+A9U false flag tag:n-n|ha tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P46736 uniprotkb:Q9Y5B9 intact:EBI-750352|uniprotkb:Q16107|uniprotkb:Q9BTZ6|uniprotkb:A6QRF8|uniprotkb:A6QRF9|uniprotkb:A8MUX5|uniprotkb:A8MWH0|uniprotkb:A9Z1Y0|uniprotkb:A9Z1Y5|uniprotkb:B1B062|uniprotkb:B4DQN7|uniprotkb:Q53YX5|ensembl:ENSP00000358474 intact:EBI-1046849|uniprotkb:Q6GMT8|uniprotkb:Q6P2F1|uniprotkb:Q6PJM1|uniprotkb:Q9NRX0|ensembl:ENSP00000216297 psi-mi:brcc3_human(display_long)|uniprotkb:BRCC3(gene name)|psi-mi:BRCC3(display_short)|uniprotkb:C6.1A(gene name synonym)|uniprotkb:CXorf53(gene name synonym)|uniprotkb:BRCC36(gene name synonym)|uniprotkb:BRCA1-A complex subunit BRCC36(gene name synonym)|uniprotkb:BRISC complex subunit BRCC36(gene name synonym)|uniprotkb:BRCA1/BRCA2-containing complex subunit 3(gene name synonym)|uniprotkb:BRCA1/BRCA2-containing complex subunit 36(gene name synonym) psi-mi:sp16h_human(display_long)|uniprotkb:Facilitates chromatin transcription complex subunit SPT16(gene name synonym)|uniprotkb:FACT 140 kDa subunit(gene name synonym)|uniprotkb:FACTp140(gene name synonym)|uniprotkb:Chromatin-specific transcription elongation factor 140 kDa subunit(gene name synonym)|uniprotkb:SUPT16H(gene name)|psi-mi:SUPT16H(display_short)|uniprotkb:FACT140(gene name synonym)|uniprotkb:FACTP140(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510058|imex:IM-12079-2 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001018065.1|refseq:NP_001229569.1|refseq:NP_077308.1|refseq:XP_016885327.1|dip:DIP-48719N|ensembl:ENSG00000185515(gene)|go:"GO:0000152"(nuclear ubiquitin ligase complex)|go:"GO:0000922"(spindle pole)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0010165"(response to X-ray)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0046872"(metal ion binding)|go:"GO:0051301"(cell division)|go:"GO:0061578"(Lys63-specific deubiquitinase activity)|go:"GO:0070122"(isopeptidase activity)|ensembl:ENST00000369462(transcript)|go:"GO:0070531"(BRCA1-A complex)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0070537"(histone H2A K63-linked deubiquitination)|go:"GO:0070552"(BRISC complex)|go:"GO:0000151"(ubiquitin ligase complex)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR033860|interpro:IPR037518|interpro:IPR040749|mint:P46736|rcsb pdb:6H3C|rcsb pdb:6R8F|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473 ensembl:ENSG00000092201(gene)|ensembl:ENST00000216297(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006260"(DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006337"(nucleosome disassembly)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0031491"(nucleosome binding)|go:"GO:0032786"(positive regulation of DNA-templated transcription, elongation)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0034724"(DNA replication-independent chromatin organization)|go:"GO:0035101"(FACT complex)|interpro:IPR000994(Peptidase M24, catalytic core)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013719(Region of unknown function DUF1747, eukaryote)|interpro:IPR013953(FACT complex subunit Spt16p/Cdc68p)|interpro:IPR029148|interpro:IPR029149|interpro:IPR033825|interpro:IPR036005|interpro:IPR040258|mint:Q9Y5B9|rcsb pdb:4Z2M|rcsb pdb:4Z2N|rcsb pdb:5E5B|rcsb pdb:5UMT|rcsb pdb:5UMU|rcsb pdb:5XM2|rcsb pdb:6UPK|rcsb pdb:6UPL|reactome:R-HSA-112382|reactome:R-HSA-167152|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-674695|reactome:R-HSA-6796648|reactome:R-HSA-6804756|reactome:R-HSA-75955|refseq:NP_009123.1|dip:DIP-42757N psi-mi:"MI:0469"(intact) caution:This sequence has been withdrawn from Uniprot.|crc64:5720358C1A2F7421 - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/11/01 rogid:4YP0TYSnZOZQ4mFEmr07XIx+AVw9606 rogid:jLK5dOF3mEyI0UbZhcNgtdlG+WI9606 intact-crc:75875F79320A0255|rigid:rxKFzekBdg4rGYdf1R4LzTy+A9U false flag tag:n-n|ha tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P46736 uniprotkb:P49736 intact:EBI-750352|uniprotkb:Q16107|uniprotkb:Q9BTZ6|uniprotkb:A6QRF8|uniprotkb:A6QRF9|uniprotkb:A8MUX5|uniprotkb:A8MWH0|uniprotkb:A9Z1Y0|uniprotkb:A9Z1Y5|uniprotkb:B1B062|uniprotkb:B4DQN7|uniprotkb:Q53YX5|ensembl:ENSP00000358474 intact:EBI-374819|uniprotkb:Q14577|uniprotkb:Q15023|uniprotkb:Q8N2V1|uniprotkb:Q969W7|uniprotkb:Q96AE1|uniprotkb:Q9BRM7|ensembl:ENSP00000265056 psi-mi:brcc3_human(display_long)|uniprotkb:BRCC3(gene name)|psi-mi:BRCC3(display_short)|uniprotkb:C6.1A(gene name synonym)|uniprotkb:CXorf53(gene name synonym)|uniprotkb:BRCC36(gene name synonym)|uniprotkb:BRCA1-A complex subunit BRCC36(gene name synonym)|uniprotkb:BRISC complex subunit BRCC36(gene name synonym)|uniprotkb:BRCA1/BRCA2-containing complex subunit 3(gene name synonym)|uniprotkb:BRCA1/BRCA2-containing complex subunit 36(gene name synonym) psi-mi:mcm2_human(display_long)|uniprotkb:MCM2(gene name)|psi-mi:MCM2(display_short)|uniprotkb:BM28(gene name synonym)|uniprotkb:CDCL1(gene name synonym)|uniprotkb:KIAA0030(gene name synonym)|uniprotkb:Minichromosome maintenance protein 2 homolog(gene name synonym)|uniprotkb:Nuclear protein BM28(gene name synonym)|uniprotkb:CCNL1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510058|imex:IM-12079-2 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001018065.1|refseq:NP_001229569.1|refseq:NP_077308.1|refseq:XP_016885327.1|dip:DIP-48719N|ensembl:ENSG00000185515(gene)|go:"GO:0000152"(nuclear ubiquitin ligase complex)|go:"GO:0000922"(spindle pole)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0010165"(response to X-ray)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0046872"(metal ion binding)|go:"GO:0051301"(cell division)|go:"GO:0061578"(Lys63-specific deubiquitinase activity)|go:"GO:0070122"(isopeptidase activity)|ensembl:ENST00000369462(transcript)|go:"GO:0070531"(BRCA1-A complex)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0070537"(histone H2A K63-linked deubiquitination)|go:"GO:0070552"(BRISC complex)|go:"GO:0000151"(ubiquitin ligase complex)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR033860|interpro:IPR037518|interpro:IPR040749|mint:P46736|rcsb pdb:6H3C|rcsb pdb:6R8F|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473 ensembl:ENSG00000073111(gene)|ensembl:ENST00000265056(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005664"(nuclear origin of replication recognition complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006915"(apoptotic process)|go:"GO:0019899"(enzyme binding)|go:"GO:0042393"(histone binding)|go:"GO:0042555"(MCM complex)|go:"GO:0046872"(metal ion binding)|go:"GO:0071162"(CMG complex)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0090102"(cochlea development)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902975"(mitotic DNA replication initiation)|go:"GO:1905775"(negative regulation of DNA helicase activity)|interpro:IPR001208(MCM)|interpro:IPR008045(MCM protein 2)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR018525|interpro:IPR027417|interpro:IPR027925|interpro:IPR031327|interpro:IPR033762|interpro:IPR041562|mint:P49736|rcsb pdb:4UUZ|rcsb pdb:5BNV|rcsb pdb:5BNX|rcsb pdb:5BO0|rcsb pdb:5C3I|rcsb pdb:5JA4|rcsb pdb:6XTX|rcsb pdb:6XTY|rcsb pdb:6YA7|rcsb pdb:7CIZ|rcsb pdb:7CJ0|reactome:R-HSA-176187|reactome:R-HSA-176974|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|reactome:R-HSA-69052|refseq:NP_004517.2|dip:DIP-31732N psi-mi:"MI:0469"(intact) caution:This sequence has been withdrawn from Uniprot.|crc64:5720358C1A2F7421 - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/11/01 rogid:4YP0TYSnZOZQ4mFEmr07XIx+AVw9606 rogid:Jt9ODNyJBwtwQ0pb/+X46vtHfE09606 intact-crc:75875F79320A0255|rigid:rxKFzekBdg4rGYdf1R4LzTy+A9U false flag tag:n-n|ha tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P46736 uniprotkb:C9JYE9 intact:EBI-750352|uniprotkb:Q16107|uniprotkb:Q9BTZ6|uniprotkb:A6QRF8|uniprotkb:A6QRF9|uniprotkb:A8MUX5|uniprotkb:A8MWH0|uniprotkb:A9Z1Y0|uniprotkb:A9Z1Y5|uniprotkb:B1B062|uniprotkb:B4DQN7|uniprotkb:Q53YX5|ensembl:ENSP00000358474 intact:EBI-2510054|ensembl:ENSP00000256117 psi-mi:brcc3_human(display_long)|uniprotkb:BRCC3(gene name)|psi-mi:BRCC3(display_short)|uniprotkb:C6.1A(gene name synonym)|uniprotkb:CXorf53(gene name synonym)|uniprotkb:BRCC36(gene name synonym)|uniprotkb:BRCA1-A complex subunit BRCC36(gene name synonym)|uniprotkb:BRISC complex subunit BRCC36(gene name synonym)|uniprotkb:BRCA1/BRCA2-containing complex subunit 3(gene name synonym)|uniprotkb:BRCA1/BRCA2-containing complex subunit 36(gene name synonym) psi-mi:c9jye9_human(display_long)|uniprotkb:E2F5(gene name)|psi-mi:E2F5(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510058|imex:IM-12079-2 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001018065.1|refseq:NP_001229569.1|refseq:NP_077308.1|refseq:XP_016885327.1|dip:DIP-48719N|ensembl:ENSG00000185515(gene)|go:"GO:0000152"(nuclear ubiquitin ligase complex)|go:"GO:0000922"(spindle pole)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0010165"(response to X-ray)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0046872"(metal ion binding)|go:"GO:0051301"(cell division)|go:"GO:0061578"(Lys63-specific deubiquitinase activity)|go:"GO:0070122"(isopeptidase activity)|ensembl:ENST00000369462(transcript)|go:"GO:0070531"(BRCA1-A complex)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0070537"(histone H2A K63-linked deubiquitination)|go:"GO:0070552"(BRISC complex)|go:"GO:0000151"(ubiquitin ligase complex)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR033860|interpro:IPR037518|interpro:IPR040749|mint:P46736|rcsb pdb:6H3C|rcsb pdb:6R8F|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473 ensembl:ENSG00000133740(gene)|ensembl:ENST00000256117(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR003316("Transcription factor E2F/dimerisation partner (TDP)")|interpro:IPR015633(E2F Family)|interpro:IPR028316|interpro:IPR032198|interpro:IPR036388|interpro:IPR036390|interpro:IPR037241 psi-mi:"MI:0469"(intact) caution:This sequence has been withdrawn from Uniprot.|crc64:5720358C1A2F7421 - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/11/01 rogid:4YP0TYSnZOZQ4mFEmr07XIx+AVw9606 rogid:0hXcWqK+tADHYMdjsjMhSf43yJ49606 intact-crc:75875F79320A0255|rigid:rxKFzekBdg4rGYdf1R4LzTy+A9U false flag tag:n-n|ha tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P46736 uniprotkb:P46379 intact:EBI-750352|uniprotkb:Q16107|uniprotkb:Q9BTZ6|uniprotkb:A6QRF8|uniprotkb:A6QRF9|uniprotkb:A8MUX5|uniprotkb:A8MWH0|uniprotkb:A9Z1Y0|uniprotkb:A9Z1Y5|uniprotkb:B1B062|uniprotkb:B4DQN7|uniprotkb:Q53YX5|ensembl:ENSP00000358474 intact:EBI-347552|uniprotkb:A2ADJ7|uniprotkb:A3KQ42|uniprotkb:A3KQ44|uniprotkb:A6NGY6|uniprotkb:A6PWF7|uniprotkb:O95874|uniprotkb:Q5HYL9|uniprotkb:Q5SQ35|uniprotkb:Q5SQ36|uniprotkb:Q5SQ37|uniprotkb:Q5SQ41|uniprotkb:Q5SRP8|uniprotkb:Q5SRP9|uniprotkb:Q5STC1|uniprotkb:Q5STX1|uniprotkb:Q5STX3|uniprotkb:Q96SA6|uniprotkb:Q9BCN4|uniprotkb:B0UX84|uniprotkb:B4DZ12|uniprotkb:B4E3V4|uniprotkb:E7EMZ4|uniprotkb:F8VXY4|ensembl:ENSP00000354368|ensembl:ENSP00000390966|ensembl:ENSP00000397894 psi-mi:brcc3_human(display_long)|uniprotkb:BRCC3(gene name)|psi-mi:BRCC3(display_short)|uniprotkb:C6.1A(gene name synonym)|uniprotkb:CXorf53(gene name synonym)|uniprotkb:BRCC36(gene name synonym)|uniprotkb:BRCA1-A complex subunit BRCC36(gene name synonym)|uniprotkb:BRISC complex subunit BRCC36(gene name synonym)|uniprotkb:BRCA1/BRCA2-containing complex subunit 3(gene name synonym)|uniprotkb:BRCA1/BRCA2-containing complex subunit 36(gene name synonym) psi-mi:bag6_human(display_long)|uniprotkb:BAT3(gene name synonym)|uniprotkb:G3(gene name synonym)|uniprotkb:HLA-B-associated transcript 3(gene name synonym)|uniprotkb:Protein G3(gene name synonym)|uniprotkb:BCL2-associated athanogene 6(gene name synonym)|uniprotkb:BAG6(gene name)|psi-mi:BAG6(display_short)|uniprotkb:BAG family molecular chaperone regulator 6(gene name synonym)|uniprotkb:Protein Scythe(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510058|imex:IM-12079-2 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001018065.1|refseq:NP_001229569.1|refseq:NP_077308.1|refseq:XP_016885327.1|dip:DIP-48719N|ensembl:ENSG00000185515(gene)|go:"GO:0000152"(nuclear ubiquitin ligase complex)|go:"GO:0000922"(spindle pole)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0010165"(response to X-ray)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0046872"(metal ion binding)|go:"GO:0051301"(cell division)|go:"GO:0061578"(Lys63-specific deubiquitinase activity)|go:"GO:0070122"(isopeptidase activity)|ensembl:ENST00000369462(transcript)|go:"GO:0070531"(BRCA1-A complex)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0070537"(histone H2A K63-linked deubiquitination)|go:"GO:0070552"(BRISC complex)|go:"GO:0000151"(ubiquitin ligase complex)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR033860|interpro:IPR037518|interpro:IPR040749|mint:P46736|rcsb pdb:6H3C|rcsb pdb:6R8F|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473 dip:DIP-31191N|refseq:NP_001092004.1|refseq:NP_001186627.1|refseq:NP_004630.3|refseq:NP_542433.1|refseq:NP_542434.1|refseq:NP_001186626.1|refseq:XP_016866776.1|ensembl:ENSG00000096155(gene)|ensembl:ENSG00000229524(gene)|ensembl:ENSG00000233348(gene)|ensembl:ENST00000361076(transcript)|ensembl:ENST00000449450(transcript)|ensembl:ENST00000451932(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0002429"(immune response-activating cell surface receptor signaling pathway)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007130"(synaptonemal complex assembly)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0016020"(membrane)|go:"GO:0018393"(internal peptidyl-lysine acetylation)|go:"GO:0030101"(natural killer cell activation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030324"(lung development)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0043022"(ribosome binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0050821"(protein stabilization)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0061857"(endoplasmic reticulum stress-induced pre-emptive quality control)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070628"(proteasome binding)|go:"GO:0071712"(ER-associated misfolded protein catabolic process)|go:"GO:0071816"(tail-anchored membrane protein insertion into ER membrane)|go:"GO:0071818"(BAT3 complex)|go:"GO:1904294"(positive regulation of ERAD pathway)|go:"GO:1904378"(maintenance of unfolded protein involved in ERAD pathway)|go:"GO:1904379"(protein localization to cytosolic proteasome complex involved in ERAD pathway)|go:"GO:1990381"(ubiquitin-specific protease binding)|interpro:IPR000626(Ubiquitin)|interpro:IPR019954|interpro:IPR021925|interpro:IPR029071|mint:P46379|rcsb pdb:1WX9|rcsb pdb:2N9P|rcsb pdb:4DWF|rcsb pdb:4EEW|rcsb pdb:4WWR|rcsb pdb:6AU8|reactome:R-HSA-9609523|rcsb pdb:4X86 psi-mi:"MI:0469"(intact) caution:This sequence has been withdrawn from Uniprot.|crc64:5720358C1A2F7421 - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/11/01 rogid:4YP0TYSnZOZQ4mFEmr07XIx+AVw9606 rogid:ghHlLBbS3yeP2mN6AOoHs+CECKU9606 intact-crc:75875F79320A0255|rigid:rxKFzekBdg4rGYdf1R4LzTy+A9U false flag tag:n-n|ha tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P46736 uniprotkb:O95299 intact:EBI-750352|uniprotkb:Q16107|uniprotkb:Q9BTZ6|uniprotkb:A6QRF8|uniprotkb:A6QRF9|uniprotkb:A8MUX5|uniprotkb:A8MWH0|uniprotkb:A9Z1Y0|uniprotkb:A9Z1Y5|uniprotkb:B1B062|uniprotkb:B4DQN7|uniprotkb:Q53YX5|ensembl:ENSP00000358474 intact:EBI-1246361|uniprotkb:Q8WXC9|ensembl:ENSP00000252711|ensembl:ENSP00000503956|ensembl:ENSP00000504765 psi-mi:brcc3_human(display_long)|uniprotkb:BRCC3(gene name)|psi-mi:BRCC3(display_short)|uniprotkb:C6.1A(gene name synonym)|uniprotkb:CXorf53(gene name synonym)|uniprotkb:BRCC36(gene name synonym)|uniprotkb:BRCA1-A complex subunit BRCC36(gene name synonym)|uniprotkb:BRISC complex subunit BRCC36(gene name synonym)|uniprotkb:BRCA1/BRCA2-containing complex subunit 3(gene name synonym)|uniprotkb:BRCA1/BRCA2-containing complex subunit 36(gene name synonym) psi-mi:nduaa_human(display_long)|uniprotkb:NDUFA10(gene name)|psi-mi:NDUFA10(display_short)|uniprotkb:NADH-ubiquinone oxidoreductase 42 kDa subunit(gene name synonym)|uniprotkb:Complex I-42kD(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510058|imex:IM-12079-2 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001018065.1|refseq:NP_001229569.1|refseq:NP_077308.1|refseq:XP_016885327.1|dip:DIP-48719N|ensembl:ENSG00000185515(gene)|go:"GO:0000152"(nuclear ubiquitin ligase complex)|go:"GO:0000922"(spindle pole)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0010165"(response to X-ray)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0046872"(metal ion binding)|go:"GO:0051301"(cell division)|go:"GO:0061578"(Lys63-specific deubiquitinase activity)|go:"GO:0070122"(isopeptidase activity)|ensembl:ENST00000369462(transcript)|go:"GO:0070531"(BRCA1-A complex)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0070537"(histone H2A K63-linked deubiquitination)|go:"GO:0070552"(BRISC complex)|go:"GO:0000151"(ubiquitin ligase complex)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR033860|interpro:IPR037518|interpro:IPR040749|mint:P46736|rcsb pdb:6H3C|rcsb pdb:6R8F|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473 refseq:NP_004535.1|ensembl:ENSG00000130414(gene)|ensembl:ENST00000252711(transcript)|ensembl:ENST00000676929(transcript)|ensembl:ENST00000678158(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|interpro:IPR015828(NADH-ubiquinone oxidoreductase, 42 kDa subunit)|interpro:IPR027417|interpro:IPR031314|mint:O95299|rcsb pdb:5XTC|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198 psi-mi:"MI:0469"(intact) caution:This sequence has been withdrawn from Uniprot.|crc64:5720358C1A2F7421 - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/11/01 rogid:4YP0TYSnZOZQ4mFEmr07XIx+AVw9606 rogid:8jwJPJ0rD9H7A4AzxPd186tpXYs9606 intact-crc:75875F79320A0255|rigid:rxKFzekBdg4rGYdf1R4LzTy+A9U false flag tag:n-n|ha tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P46736 uniprotkb:P48047 intact:EBI-750352|uniprotkb:Q16107|uniprotkb:Q9BTZ6|uniprotkb:A6QRF8|uniprotkb:A6QRF9|uniprotkb:A8MUX5|uniprotkb:A8MWH0|uniprotkb:A9Z1Y0|uniprotkb:A9Z1Y5|uniprotkb:B1B062|uniprotkb:B4DQN7|uniprotkb:Q53YX5|ensembl:ENSP00000358474 intact:EBI-355815|uniprotkb:Q5U042|uniprotkb:Q6IBI2|uniprotkb:B2R4E2|ensembl:ENSP00000290299 psi-mi:brcc3_human(display_long)|uniprotkb:BRCC3(gene name)|psi-mi:BRCC3(display_short)|uniprotkb:C6.1A(gene name synonym)|uniprotkb:CXorf53(gene name synonym)|uniprotkb:BRCC36(gene name synonym)|uniprotkb:BRCA1-A complex subunit BRCC36(gene name synonym)|uniprotkb:BRISC complex subunit BRCC36(gene name synonym)|uniprotkb:BRCA1/BRCA2-containing complex subunit 3(gene name synonym)|uniprotkb:BRCA1/BRCA2-containing complex subunit 36(gene name synonym) psi-mi:atpo_human(display_long)|uniprotkb:ATP5PO(gene name)|psi-mi:ATP5PO(display_short)|uniprotkb:ATP synthase peripheral stalk subunit OSCP(gene name synonym)|uniprotkb:ATP5O(gene name synonym)|uniprotkb:ATPO(gene name synonym)|uniprotkb:Oligomycin sensitivity conferral protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510058|imex:IM-12079-2 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001018065.1|refseq:NP_001229569.1|refseq:NP_077308.1|refseq:XP_016885327.1|dip:DIP-48719N|ensembl:ENSG00000185515(gene)|go:"GO:0000152"(nuclear ubiquitin ligase complex)|go:"GO:0000922"(spindle pole)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0010165"(response to X-ray)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0046872"(metal ion binding)|go:"GO:0051301"(cell division)|go:"GO:0061578"(Lys63-specific deubiquitinase activity)|go:"GO:0070122"(isopeptidase activity)|ensembl:ENST00000369462(transcript)|go:"GO:0070531"(BRCA1-A complex)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0070537"(histone H2A K63-linked deubiquitination)|go:"GO:0070552"(BRISC complex)|go:"GO:0000151"(ubiquitin ligase complex)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR033860|interpro:IPR037518|interpro:IPR040749|mint:P46736|rcsb pdb:6H3C|rcsb pdb:6R8F|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473 refseq:NP_001688.1|ensembl:ENSG00000241837(gene)|ensembl:ENST00000290299(transcript)|go:"GO:0000274"(mitochondrial proton-transporting ATP synthase, stator stalk)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005753"(mitochondrial proton-transporting ATP synthase complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0015986"(ATP synthesis coupled proton transport)|go:"GO:0042776"(mitochondrial ATP synthesis coupled proton transport)|go:"GO:0045261"("proton-transporting ATP synthase complex, catalytic core F(1)")|go:"GO:0046933"(proton-transporting ATP synthase activity, rotational mechanism)|go:"GO:1902600"(proton transmembrane transport)|interpro:IPR000711(ATPase, F1 complex, OSCP/delta subunit)|interpro:IPR020781|interpro:IPR026015|mint:P48047|reactome:R-HSA-163210|reactome:R-HSA-8949613 psi-mi:"MI:0469"(intact) caution:This sequence has been withdrawn from Uniprot.|crc64:5720358C1A2F7421 - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/11/01 rogid:4YP0TYSnZOZQ4mFEmr07XIx+AVw9606 rogid:4lQel+z57OEHJXVWW8ijNyp2h2U9606 intact-crc:75875F79320A0255|rigid:rxKFzekBdg4rGYdf1R4LzTy+A9U false flag tag:n-n|ha tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P46736 uniprotkb:Q9NWV8 intact:EBI-750352|uniprotkb:Q16107|uniprotkb:Q9BTZ6|uniprotkb:A6QRF8|uniprotkb:A6QRF9|uniprotkb:A8MUX5|uniprotkb:A8MWH0|uniprotkb:A9Z1Y0|uniprotkb:A9Z1Y5|uniprotkb:B1B062|uniprotkb:B4DQN7|uniprotkb:Q53YX5|ensembl:ENSP00000358474 intact:EBI-745725|uniprotkb:Q6FIA0|uniprotkb:Q9P018|uniprotkb:A8MQT0|uniprotkb:B4DRY9|uniprotkb:B4DVR1|ensembl:ENSP00000352408|ensembl:ENSP00000470920|ensembl:ENSP00000471605 psi-mi:brcc3_human(display_long)|uniprotkb:BRCC3(gene name)|psi-mi:BRCC3(display_short)|uniprotkb:C6.1A(gene name synonym)|uniprotkb:CXorf53(gene name synonym)|uniprotkb:BRCC36(gene name synonym)|uniprotkb:BRCA1-A complex subunit BRCC36(gene name synonym)|uniprotkb:BRISC complex subunit BRCC36(gene name synonym)|uniprotkb:BRCA1/BRCA2-containing complex subunit 3(gene name synonym)|uniprotkb:BRCA1/BRCA2-containing complex subunit 36(gene name synonym) psi-mi:baba1_human(display_long)|uniprotkb:BABAM1(gene name)|psi-mi:BABAM1(display_short)|uniprotkb:HSPC142(orf name)|uniprotkb:C19orf62(gene name synonym)|uniprotkb:NBA1(gene name synonym)|uniprotkb:Mediator of RAP80 interactions and targeting subunit of 40 kDa(gene name synonym)|uniprotkb:New component of the BRCA1-A complex(gene name synonym)|uniprotkb:MERIT40(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510058|imex:IM-12079-2 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001018065.1|refseq:NP_001229569.1|refseq:NP_077308.1|refseq:XP_016885327.1|dip:DIP-48719N|ensembl:ENSG00000185515(gene)|go:"GO:0000152"(nuclear ubiquitin ligase complex)|go:"GO:0000922"(spindle pole)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0010165"(response to X-ray)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0046872"(metal ion binding)|go:"GO:0051301"(cell division)|go:"GO:0061578"(Lys63-specific deubiquitinase activity)|go:"GO:0070122"(isopeptidase activity)|ensembl:ENST00000369462(transcript)|go:"GO:0070531"(BRCA1-A complex)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0070537"(histone H2A K63-linked deubiquitination)|go:"GO:0070552"(BRISC complex)|go:"GO:0000151"(ubiquitin ligase complex)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR033860|interpro:IPR037518|interpro:IPR040749|mint:P46736|rcsb pdb:6H3C|rcsb pdb:6R8F|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473 refseq:NP_001028721.1|refseq:NP_054892.2|ensembl:ENSG00000105393(gene)|ensembl:ENST00000359435(transcript)|ensembl:ENST00000598188(transcript)|ensembl:ENST00000601043(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006325"(chromatin organization)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016604"(nuclear body)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0051301"(cell division)|go:"GO:0070531"(BRCA1-A complex)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0070552"(BRISC complex)|interpro:IPR026126|interpro:IPR036465|mint:Q9NWV8|rcsb pdb:6H3C|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473|refseq:NP_001275685.1|refseq:NP_001275686.1 psi-mi:"MI:0469"(intact) caution:This sequence has been withdrawn from Uniprot.|crc64:5720358C1A2F7421 - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/11/01 rogid:4YP0TYSnZOZQ4mFEmr07XIx+AVw9606 rogid:o71OvjzuL/7w4247ap7fm6i3pXU9606 intact-crc:75875F79320A0255|rigid:rxKFzekBdg4rGYdf1R4LzTy+A9U false flag tag:n-n|ha tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P46736 uniprotkb:P39656 intact:EBI-750352|uniprotkb:Q16107|uniprotkb:Q9BTZ6|uniprotkb:A6QRF8|uniprotkb:A6QRF9|uniprotkb:A8MUX5|uniprotkb:A8MWH0|uniprotkb:A9Z1Y0|uniprotkb:A9Z1Y5|uniprotkb:B1B062|uniprotkb:B4DQN7|uniprotkb:Q53YX5|ensembl:ENSP00000358474 intact:EBI-358866|uniprotkb:O43244|uniprotkb:Q8NI93|uniprotkb:Q9BUI2|uniprotkb:B2RDQ4|uniprotkb:Q5VWA5|ensembl:ENSP00000399457|uniprotkb:B4DJE3|uniprotkb:B4DLI2 psi-mi:brcc3_human(display_long)|uniprotkb:BRCC3(gene name)|psi-mi:BRCC3(display_short)|uniprotkb:C6.1A(gene name synonym)|uniprotkb:CXorf53(gene name synonym)|uniprotkb:BRCC36(gene name synonym)|uniprotkb:BRCA1-A complex subunit BRCC36(gene name synonym)|uniprotkb:BRISC complex subunit BRCC36(gene name synonym)|uniprotkb:BRCA1/BRCA2-containing complex subunit 3(gene name synonym)|uniprotkb:BRCA1/BRCA2-containing complex subunit 36(gene name synonym) psi-mi:ost48_human(display_long)|uniprotkb:DDOST(gene name)|psi-mi:DDOST(display_short)|uniprotkb:KIAA0115(gene name synonym)|uniprotkb:OST48(gene name synonym)|uniprotkb:OK/SW-cl.45(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510058|imex:IM-12079-2 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001018065.1|refseq:NP_001229569.1|refseq:NP_077308.1|refseq:XP_016885327.1|dip:DIP-48719N|ensembl:ENSG00000185515(gene)|go:"GO:0000152"(nuclear ubiquitin ligase complex)|go:"GO:0000922"(spindle pole)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0010165"(response to X-ray)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0046872"(metal ion binding)|go:"GO:0051301"(cell division)|go:"GO:0061578"(Lys63-specific deubiquitinase activity)|go:"GO:0070122"(isopeptidase activity)|ensembl:ENST00000369462(transcript)|go:"GO:0070531"(BRCA1-A complex)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0070537"(histone H2A K63-linked deubiquitination)|go:"GO:0070552"(BRISC complex)|go:"GO:0000151"(ubiquitin ligase complex)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR033860|interpro:IPR037518|interpro:IPR040749|mint:P46736|rcsb pdb:6H3C|rcsb pdb:6R8F|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473 refseq:NP_005207.2|ensembl:ENSG00000244038(gene)|ensembl:ENST00000415136(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006486"(protein glycosylation)|go:"GO:0006487"(protein N-linked glycosylation)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0008250"(oligosaccharyltransferase complex)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0018279"(protein N-linked glycosylation via asparagine)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0034097"(response to cytokine)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042110"(T cell activation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR005013(Dolichyl-diphosphooligosaccharide-protein glycosyltransferase 48kDa subunit)|mint:P39656|rcsb pdb:6S7O|rcsb pdb:6S7T|reactome:R-HSA-1799339|reactome:R-HSA-446203|reactome:R-HSA-6798695|reactome:R-HSA-879415|reactome:R-HSA-9694548 psi-mi:"MI:0469"(intact) caution:This sequence has been withdrawn from Uniprot.|crc64:5720358C1A2F7421 - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/11/01 rogid:4YP0TYSnZOZQ4mFEmr07XIx+AVw9606 rogid:utOlgvpqe2JHEJHk4gIp8tXwv/I9606 intact-crc:75875F79320A0255|rigid:rxKFzekBdg4rGYdf1R4LzTy+A9U false flag tag:n-n|ha tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P46736 uniprotkb:Q9NXR7 intact:EBI-750352|uniprotkb:Q16107|uniprotkb:Q9BTZ6|uniprotkb:A6QRF8|uniprotkb:A6QRF9|uniprotkb:A8MUX5|uniprotkb:A8MWH0|uniprotkb:A9Z1Y0|uniprotkb:A9Z1Y5|uniprotkb:B1B062|uniprotkb:B4DQN7|uniprotkb:Q53YX5|ensembl:ENSP00000358474 intact:EBI-949389|ensembl:ENSP00000339371|ensembl:ENSP00000368945|uniprotkb:Q13880|uniprotkb:Q96P06|uniprotkb:A8K4X1|uniprotkb:Q4ZFX8|uniprotkb:Q53SD0|uniprotkb:Q969X9|uniprotkb:D6W562|uniprotkb:D6W563 psi-mi:brcc3_human(display_long)|uniprotkb:BRCC3(gene name)|psi-mi:BRCC3(display_short)|uniprotkb:C6.1A(gene name synonym)|uniprotkb:CXorf53(gene name synonym)|uniprotkb:BRCC36(gene name synonym)|uniprotkb:BRCA1-A complex subunit BRCC36(gene name synonym)|uniprotkb:BRISC complex subunit BRCC36(gene name synonym)|uniprotkb:BRCA1/BRCA2-containing complex subunit 3(gene name synonym)|uniprotkb:BRCA1/BRCA2-containing complex subunit 36(gene name synonym) psi-mi:baba2_human(display_long)|uniprotkb:BABAM2(gene name)|psi-mi:BABAM2(display_short)|uniprotkb:BRCA1-A complex subunit BRE(gene name synonym)|uniprotkb:BRCA1/BRCA2-containing complex subunit 45(gene name synonym)|uniprotkb:BRCC45(gene name synonym)|uniprotkb:BRE(gene name synonym)|uniprotkb:Brain and reproductive organ-expressed protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510058|imex:IM-12079-2 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001018065.1|refseq:NP_001229569.1|refseq:NP_077308.1|refseq:XP_016885327.1|dip:DIP-48719N|ensembl:ENSG00000185515(gene)|go:"GO:0000152"(nuclear ubiquitin ligase complex)|go:"GO:0000922"(spindle pole)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0010165"(response to X-ray)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0046872"(metal ion binding)|go:"GO:0051301"(cell division)|go:"GO:0061578"(Lys63-specific deubiquitinase activity)|go:"GO:0070122"(isopeptidase activity)|ensembl:ENST00000369462(transcript)|go:"GO:0070531"(BRCA1-A complex)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0070537"(histone H2A K63-linked deubiquitination)|go:"GO:0070552"(BRISC complex)|go:"GO:0000151"(ubiquitin ligase complex)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR033860|interpro:IPR037518|interpro:IPR040749|mint:P46736|rcsb pdb:6H3C|rcsb pdb:6R8F|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473 ensembl:ENSG00000158019(gene)|ensembl:ENST00000342045(transcript)|ensembl:ENST00000379624(transcript)|go:"GO:0000152"(nuclear ubiquitin ligase complex)|go:"GO:0000268"(peroxisome targeting sequence binding)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0007165"(signal transduction)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0051301"(cell division)|go:"GO:0070531"(BRCA1-A complex)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0070552"(BRISC complex)|interpro:IPR010358(Brain and reproductive organ-expressed)|rcsb pdb:6H3C|rcsb pdb:6R8F|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473|go:"GO:0006302"(double-strand break repair)|refseq:NP_004890.2|refseq:NP_954661.1|refseq:NP_954662.1|refseq:NP_954663.1|refseq:NP_954664.1|refseq:NP_001248769.1|refseq:NP_001316041.1|refseq:NP_001316042.1 psi-mi:"MI:0469"(intact) caution:This sequence has been withdrawn from Uniprot.|crc64:5720358C1A2F7421 - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/11/01 rogid:4YP0TYSnZOZQ4mFEmr07XIx+AVw9606 rogid:ULbrw0O7e5M0Hzho3d05OlUnEGM9606 intact-crc:75875F79320A0255|rigid:rxKFzekBdg4rGYdf1R4LzTy+A9U false flag tag:n-n|ha tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q92905 uniprotkb:P61201 intact:EBI-594661|uniprotkb:O15386|uniprotkb:Q6AW95|uniprotkb:Q86WQ4|uniprotkb:Q9BQ17|ensembl:ENSP00000350512 intact:EBI-1050386|uniprotkb:O88950|uniprotkb:Q15647|uniprotkb:Q6FGP4|uniprotkb:Q9BY54|uniprotkb:Q9R249|uniprotkb:Q9UNI2|uniprotkb:Q9UNQ5|ensembl:ENSP00000373553 psi-mi:csn5_human(display_long)|uniprotkb:Jun activation domain-binding protein 1(gene name synonym)|uniprotkb:COPS5(gene name)|psi-mi:COPS5(display_short)|uniprotkb:CSN5(gene name synonym)|uniprotkb:JAB1(gene name synonym) psi-mi:csn2_human(display_long)|uniprotkb:JAB1-containing signalosome subunit 2(gene name synonym)|uniprotkb:Thyroid receptor-interacting protein 15(gene name synonym)|uniprotkb:Alien homolog(gene name synonym)|uniprotkb:COPS2(gene name)|psi-mi:COPS2(display_short)|uniprotkb:CSN2(gene name synonym)|uniprotkb:TRIP15(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510150|imex:IM-12079-52 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006828.2|dip:DIP-34546N|ensembl:ENSG00000121022(gene)|ensembl:ENST00000357849(transcript)|go:"GO:0000338"(protein deneddylation)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006412"(translation)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019784"(NEDD8-specific protease activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0035718"(macrophage migration inhibitory factor binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070122"(isopeptidase activity)|go:"GO:1903894"(regulation of IRE1-mediated unfolded protein response)|go:"GO:1990182"(exosomal secretion)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR037518|interpro:IPR037740|interpro:IPR040961|mint:Q92905|rcsb pdb:4D10|rcsb pdb:4D18|rcsb pdb:4F7O|rcsb pdb:4WSN|rcsb pdb:5JOG|rcsb pdb:5JOH|rcsb pdb:5M5Q|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|reactome:R-HSA-5696394|reactome:R-HSA-6781823|reactome:R-HSA-8856825|reactome:R-HSA-8951664 refseq:NP_001137359.1|refseq:NP_004227.1|ensembl:ENSG00000166200(gene)|ensembl:ENST00000388901(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000338"(protein deneddylation)|go:"GO:0001833"(inner cell mass cell proliferation)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0030182"(neuron differentiation)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:1903507"(negative regulation of nucleic acid-templated transcription)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR036390|interpro:IPR037750|mint:P61201|rcsb pdb:4D10|rcsb pdb:4D18|rcsb pdb:4WSN|rcsb pdb:6A73|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|rcsb pdb:6R7N|reactome:R-HSA-5696394|reactome:R-HSA-6781823|reactome:R-HSA-8856825|reactome:R-HSA-8951664|reactome:R-HSA-9013422|dip:DIP-42076N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:GMgH8dW3KWILX6Mr/+XrgAV3xY49606 rogid:MrlEHktIBvvcQux7Z7kqYJYgbbs9606 intact-crc:62C682BFC2A95F82|rigid:idT5K7H/rzoG1Ge3VgtYYQZGUuo false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q92905 uniprotkb:Q86XK2 intact:EBI-594661|uniprotkb:O15386|uniprotkb:Q6AW95|uniprotkb:Q86WQ4|uniprotkb:Q9BQ17|ensembl:ENSP00000350512 intact:EBI-1047804|uniprotkb:Q9H9L1|uniprotkb:Q9NR14|uniprotkb:Q9UFK1|uniprotkb:Q52ZP1|uniprotkb:Q53EP7|uniprotkb:Q8IXG3|uniprotkb:Q96E90|uniprotkb:Q9H6V8|uniprotkb:Q9UHI1|uniprotkb:Q9UKC2|uniprotkb:Q53RT5|uniprotkb:A1L491|ensembl:ENSP00000384823 psi-mi:csn5_human(display_long)|uniprotkb:Jun activation domain-binding protein 1(gene name synonym)|uniprotkb:COPS5(gene name)|psi-mi:COPS5(display_short)|uniprotkb:CSN5(gene name synonym)|uniprotkb:JAB1(gene name synonym) psi-mi:fbx11_human(display_long)|uniprotkb:Vitiligo-associated protein 1(gene name synonym)|uniprotkb:FBXO11(gene name)|psi-mi:FBXO11(display_short)|uniprotkb:FBX11(gene name synonym)|uniprotkb:VIT1(gene name synonym)|uniprotkb:PRMT9(gene name synonym)|uniprotkb:Protein arginine N-methyltransferase 9(gene name synonym)|uniprotkb:UG063H01(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510150|imex:IM-12079-52 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006828.2|dip:DIP-34546N|ensembl:ENSG00000121022(gene)|ensembl:ENST00000357849(transcript)|go:"GO:0000338"(protein deneddylation)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006412"(translation)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019784"(NEDD8-specific protease activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0035718"(macrophage migration inhibitory factor binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070122"(isopeptidase activity)|go:"GO:1903894"(regulation of IRE1-mediated unfolded protein response)|go:"GO:1990182"(exosomal secretion)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR037518|interpro:IPR037740|interpro:IPR040961|mint:Q92905|rcsb pdb:4D10|rcsb pdb:4D18|rcsb pdb:4F7O|rcsb pdb:4WSN|rcsb pdb:5JOG|rcsb pdb:5JOH|rcsb pdb:5M5Q|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|reactome:R-HSA-5696394|reactome:R-HSA-6781823|reactome:R-HSA-8856825|reactome:R-HSA-8951664 refseq:NP_001177203.1|refseq:XP_016860506.1|refseq:NP_079409.3|refseq:XP_005264629.1|dip:DIP-35680N|ensembl:ENSG00000138081(gene)|ensembl:ENST00000403359(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016274"(protein-arginine N-methyltransferase activity)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0042981"(regulation of apoptotic process)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR003126(Zinc finger, N-recognin)|interpro:IPR006626(Parallel beta-helix repeat)|interpro:IPR006633(Carbohydrate-binding and sugar hydrolysis)|interpro:IPR007742(Periplasmic copper-binding)|interpro:IPR011050(Pectin lyase fold/virulence factor)|interpro:IPR012334(Pectin lyase fold)|interpro:IPR022441|interpro:IPR029799|interpro:IPR036047|interpro:IPR039448|rcsb pdb:5VMD|reactome:R-HSA-8951664|reactome:R-HSA-983168 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:GMgH8dW3KWILX6Mr/+XrgAV3xY49606 rogid:7tSKElIYe8osUxG4NtKI0lWkLak9606 intact-crc:62C682BFC2A95F82|rigid:idT5K7H/rzoG1Ge3VgtYYQZGUuo false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q92905 uniprotkb:Q9BX70 intact:EBI-594661|uniprotkb:O15386|uniprotkb:Q6AW95|uniprotkb:Q86WQ4|uniprotkb:Q9BQ17|ensembl:ENSP00000350512 intact:EBI-710091|uniprotkb:O60418|uniprotkb:O75248|uniprotkb:Q4VBZ1|uniprotkb:Q6IAC5|uniprotkb:Q7Z5W0|uniprotkb:Q96SX8|uniprotkb:Q9NPS1|uniprotkb:Q9NX81|ensembl:ENSP00000255608 psi-mi:csn5_human(display_long)|uniprotkb:Jun activation domain-binding protein 1(gene name synonym)|uniprotkb:COPS5(gene name)|psi-mi:COPS5(display_short)|uniprotkb:CSN5(gene name synonym)|uniprotkb:JAB1(gene name synonym) psi-mi:btbd2_human(display_long)|uniprotkb:BTBD2(gene name)|psi-mi:BTBD2(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510150|imex:IM-12079-52 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006828.2|dip:DIP-34546N|ensembl:ENSG00000121022(gene)|ensembl:ENST00000357849(transcript)|go:"GO:0000338"(protein deneddylation)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006412"(translation)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019784"(NEDD8-specific protease activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0035718"(macrophage migration inhibitory factor binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070122"(isopeptidase activity)|go:"GO:1903894"(regulation of IRE1-mediated unfolded protein response)|go:"GO:1990182"(exosomal secretion)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR037518|interpro:IPR037740|interpro:IPR040961|mint:Q92905|rcsb pdb:4D10|rcsb pdb:4D18|rcsb pdb:4F7O|rcsb pdb:4WSN|rcsb pdb:5JOG|rcsb pdb:5JOH|rcsb pdb:5M5Q|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|reactome:R-HSA-5696394|reactome:R-HSA-6781823|reactome:R-HSA-8856825|reactome:R-HSA-8951664 refseq:XP_011526429.1|refseq:NP_060267.2|ensembl:ENSG00000133243(gene)|ensembl:ENST00000255608(transcript)|go:"GO:0000932"(P-body)|go:"GO:0005829"(cytosol)|go:"GO:0022008"(neurogenesis)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR011705(BTB/Kelch-associated)|interpro:IPR012983(PHR)|interpro:IPR038648|mint:Q9BX70|rcsb pdb:3NO8 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:GMgH8dW3KWILX6Mr/+XrgAV3xY49606 rogid:/G2pfpWgbGkgFcMLzMcWg5isDOE9606 intact-crc:62C682BFC2A95F82|rigid:idT5K7H/rzoG1Ge3VgtYYQZGUuo false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q92905 uniprotkb:Q13620 intact:EBI-594661|uniprotkb:O15386|uniprotkb:Q6AW95|uniprotkb:Q86WQ4|uniprotkb:Q9BQ17|ensembl:ENSP00000350512 intact:EBI-456067|uniprotkb:Q6PIE4|uniprotkb:Q6UP07|uniprotkb:B3KVX4|uniprotkb:B7Z5K8|uniprotkb:Q7Z673|uniprotkb:Q9BY37|uniprotkb:Q9UEB7|uniprotkb:Q9UED7|uniprotkb:B1APK5|ensembl:ENSP00000505084|ensembl:ENSP00000505176|ensembl:ENSP00000506259 psi-mi:csn5_human(display_long)|uniprotkb:Jun activation domain-binding protein 1(gene name synonym)|uniprotkb:COPS5(gene name)|psi-mi:COPS5(display_short)|uniprotkb:CSN5(gene name synonym)|uniprotkb:JAB1(gene name synonym) psi-mi:cul4b_human(display_long)|uniprotkb:CUL4B(gene name)|psi-mi:CUL4B(display_short)|uniprotkb:KIAA0695(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510150|imex:IM-12079-52 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006828.2|dip:DIP-34546N|ensembl:ENSG00000121022(gene)|ensembl:ENST00000357849(transcript)|go:"GO:0000338"(protein deneddylation)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006412"(translation)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019784"(NEDD8-specific protease activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0035718"(macrophage migration inhibitory factor binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070122"(isopeptidase activity)|go:"GO:1903894"(regulation of IRE1-mediated unfolded protein response)|go:"GO:1990182"(exosomal secretion)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR037518|interpro:IPR037740|interpro:IPR040961|mint:Q92905|rcsb pdb:4D10|rcsb pdb:4D18|rcsb pdb:4F7O|rcsb pdb:4WSN|rcsb pdb:5JOG|rcsb pdb:5JOH|rcsb pdb:5M5Q|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|reactome:R-HSA-5696394|reactome:R-HSA-6781823|reactome:R-HSA-8856825|reactome:R-HSA-8951664 refseq:NP_001073341.1|refseq:NP_003579.3|ensembl:ENST00000371322|ensembl:ENSP00000360373|ensembl:ENST00000371323|ensembl:ENSP00000360374|ensembl:ENSP00000505084|ensembl:ENSP00000506259|ensembl:ENSP00000505176|refseq:XP_011529702.1|dip:DIP-31609N|ensembl:ENSG00000158290(gene)|ensembl:ENST00000680673(transcript)|ensembl:ENST00000681253(transcript)|ensembl:ENST00000681652(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031175"(neuron projection development)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031465"(Cul4B-RING E3 ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035518"(histone H2A monoubiquitination)|go:"GO:0042254"(ribosome biogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070914"(UV-damage excision repair)|reactome:R-HSA-5696394|reactome:R-HSA-5696395|reactome:R-HSA-5696400|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-8951664|go:"GO:0080008"(Cul4-RING E3 ubiquitin ligase complex)|interpro:IPR001373(Cullin, N-terminal region)|interpro:IPR016157(Cullin, conserved site)|interpro:IPR016158(Cullin homology)|interpro:IPR016159(Cullin repeat-like)|interpro:IPR019559|interpro:IPR033044|interpro:IPR036317|interpro:IPR036388|interpro:IPR036390|mint:Q13620|rcsb pdb:2DO7|rcsb pdb:4A0C|rcsb pdb:4A0L|rcsb pdb:4A64|reactome:R-HSA-110314 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:GMgH8dW3KWILX6Mr/+XrgAV3xY49606 rogid:D75aMBt3GaBdpBt5Mxsxk7yiRVg9606 intact-crc:62C682BFC2A95F82|rigid:idT5K7H/rzoG1Ge3VgtYYQZGUuo false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q92905 uniprotkb:Q9H496 intact:EBI-594661|uniprotkb:O15386|uniprotkb:Q6AW95|uniprotkb:Q86WQ4|uniprotkb:Q9BQ17|ensembl:ENSP00000350512 intact:EBI-2510146|ensembl:ENSP00000485355|uniprotkb:Q05BU2 psi-mi:csn5_human(display_long)|uniprotkb:Jun activation domain-binding protein 1(gene name synonym)|uniprotkb:COPS5(gene name)|psi-mi:COPS5(display_short)|uniprotkb:CSN5(gene name synonym)|uniprotkb:JAB1(gene name synonym) psi-mi:ifg15_human(display_long)|uniprotkb:IFRG15(gene name synonym)|uniprotkb:TOR1AIP2(gene name)|psi-mi:TOR1AIP2(display_short)|uniprotkb:15 kDa interferon-responsive protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510150|imex:IM-12079-52 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006828.2|dip:DIP-34546N|ensembl:ENSG00000121022(gene)|ensembl:ENST00000357849(transcript)|go:"GO:0000338"(protein deneddylation)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006412"(translation)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019784"(NEDD8-specific protease activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0035718"(macrophage migration inhibitory factor binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070122"(isopeptidase activity)|go:"GO:1903894"(regulation of IRE1-mediated unfolded protein response)|go:"GO:1990182"(exosomal secretion)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR037518|interpro:IPR037740|interpro:IPR040961|mint:Q92905|rcsb pdb:4D10|rcsb pdb:4D18|rcsb pdb:4F7O|rcsb pdb:4WSN|rcsb pdb:5JOG|rcsb pdb:5JOH|rcsb pdb:5M5Q|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|reactome:R-HSA-5696394|reactome:R-HSA-6781823|reactome:R-HSA-8856825|reactome:R-HSA-8951664 ensembl:ENSG00000169905(gene)|ensembl:ENST00000482587(transcript)|refseq:NP_071742.1|refseq:XP_016855966.1|refseq:XP_016855967.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:GMgH8dW3KWILX6Mr/+XrgAV3xY49606 rogid:JTZAx1BSMfctWtiQyePC82lYQnM9606 intact-crc:62C682BFC2A95F82|rigid:idT5K7H/rzoG1Ge3VgtYYQZGUuo false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q92905 uniprotkb:Q96EF6 intact:EBI-594661|uniprotkb:O15386|uniprotkb:Q6AW95|uniprotkb:Q86WQ4|uniprotkb:Q9BQ17|ensembl:ENSP00000350512 intact:EBI-2510157|ensembl:ENSP00000292852|ensembl:ENSP00000470361|ensembl:ENSP00000488997|ensembl:ENSP00000489327|uniprotkb:Q96LQ4 psi-mi:csn5_human(display_long)|uniprotkb:Jun activation domain-binding protein 1(gene name synonym)|uniprotkb:COPS5(gene name)|psi-mi:COPS5(display_short)|uniprotkb:CSN5(gene name synonym)|uniprotkb:JAB1(gene name synonym) psi-mi:fbx17_human(display_long)|uniprotkb:FBXO17(gene name)|psi-mi:FBXO17(display_short)|uniprotkb:FBG4(gene name synonym)|uniprotkb:FBX17(gene name synonym)|uniprotkb:FBX26(gene name synonym)|uniprotkb:FBXO26(gene name synonym)|uniprotkb:F-box only protein 26(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510150|imex:IM-12079-52 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006828.2|dip:DIP-34546N|ensembl:ENSG00000121022(gene)|ensembl:ENST00000357849(transcript)|go:"GO:0000338"(protein deneddylation)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006412"(translation)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019784"(NEDD8-specific protease activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0035718"(macrophage migration inhibitory factor binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070122"(isopeptidase activity)|go:"GO:1903894"(regulation of IRE1-mediated unfolded protein response)|go:"GO:1990182"(exosomal secretion)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR037518|interpro:IPR037740|interpro:IPR040961|mint:Q92905|rcsb pdb:4D10|rcsb pdb:4D18|rcsb pdb:4F7O|rcsb pdb:4WSN|rcsb pdb:5JOG|rcsb pdb:5JOH|rcsb pdb:5M5Q|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|reactome:R-HSA-5696394|reactome:R-HSA-6781823|reactome:R-HSA-8856825|reactome:R-HSA-8951664 ensembl:ENSG00000269190(gene)|ensembl:ENSG00000282954(gene)|ensembl:ENST00000634982(transcript)|ensembl:ENST00000635115(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006516"(glycoprotein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR007397(F-box associated region)|interpro:IPR008979(Galactose-binding like)|ensembl:ENST00000292852(transcript)|ensembl:ENST00000595329(transcript)|interpro:IPR036047|interpro:IPR039752|mint:Q96EF6|reactome:R-HSA-8951664|reactome:R-HSA-983168|refseq:NP_079183.4|refseq:NP_680474.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:GMgH8dW3KWILX6Mr/+XrgAV3xY49606 rogid:yc7kMZQhjtDMtTD97TFdPZnGPPk9606 intact-crc:62C682BFC2A95F82|rigid:idT5K7H/rzoG1Ge3VgtYYQZGUuo false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q92905 uniprotkb:Q96M94 intact:EBI-594661|uniprotkb:O15386|uniprotkb:Q6AW95|uniprotkb:Q86WQ4|uniprotkb:Q9BQ17|ensembl:ENSP00000350512 intact:EBI-2510129|ensembl:ENSP00000332791|uniprotkb:Q9C0I6|uniprotkb:Q32MN3|uniprotkb:Q96BM6|uniprotkb:Q8NDA3 psi-mi:csn5_human(display_long)|uniprotkb:Jun activation domain-binding protein 1(gene name synonym)|uniprotkb:COPS5(gene name)|psi-mi:COPS5(display_short)|uniprotkb:CSN5(gene name synonym)|uniprotkb:JAB1(gene name synonym) psi-mi:klh15_human(display_long)|uniprotkb:KLHL15(gene name)|psi-mi:KLHL15(display_short)|uniprotkb:KIAA1677(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510150|imex:IM-12079-52 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006828.2|dip:DIP-34546N|ensembl:ENSG00000121022(gene)|ensembl:ENST00000357849(transcript)|go:"GO:0000338"(protein deneddylation)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006412"(translation)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019784"(NEDD8-specific protease activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0035718"(macrophage migration inhibitory factor binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070122"(isopeptidase activity)|go:"GO:1903894"(regulation of IRE1-mediated unfolded protein response)|go:"GO:1990182"(exosomal secretion)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR037518|interpro:IPR037740|interpro:IPR040961|mint:Q92905|rcsb pdb:4D10|rcsb pdb:4D18|rcsb pdb:4F7O|rcsb pdb:4WSN|rcsb pdb:5JOG|rcsb pdb:5JOH|rcsb pdb:5M5Q|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|reactome:R-HSA-5696394|reactome:R-HSA-6781823|reactome:R-HSA-8856825|reactome:R-HSA-8951664 ensembl:ENSG00000174010(gene)|ensembl:ENST00000328046(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0071630"(nuclear protein quality control by the ubiquitin-proteasome system)|go:"GO:2000042"(negative regulation of double-strand break repair via homologous recombination)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR011705(BTB/Kelch-associated)|interpro:IPR015915(Kelch-type beta propeller)|interpro:IPR017096(Kelch-like protein, gigaxonin)|interpro:IPR030597|refseq:NP_085127.2|refseq:XP_006724581.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:GMgH8dW3KWILX6Mr/+XrgAV3xY49606 rogid:Xkm72585iSVnSMqN1b0XM79Pd2g9606 intact-crc:62C682BFC2A95F82|rigid:idT5K7H/rzoG1Ge3VgtYYQZGUuo false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q92905 uniprotkb:Q9BT78 intact:EBI-594661|uniprotkb:O15386|uniprotkb:Q6AW95|uniprotkb:Q86WQ4|uniprotkb:Q9BQ17|ensembl:ENSP00000350512 intact:EBI-742413|uniprotkb:Q561W7|uniprotkb:Q9NW31|uniprotkb:Q9Y677|uniprotkb:B3KN88|ensembl:ENSP00000264389|uniprotkb:B3KST5 psi-mi:csn5_human(display_long)|uniprotkb:Jun activation domain-binding protein 1(gene name synonym)|uniprotkb:COPS5(gene name)|psi-mi:COPS5(display_short)|uniprotkb:CSN5(gene name synonym)|uniprotkb:JAB1(gene name synonym) psi-mi:csn4_human(display_long)|uniprotkb:COPS4(gene name)|psi-mi:COPS4(display_short)|uniprotkb:CSN4(gene name synonym)|uniprotkb:JAB1-containing signalosome subunit 4(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510150|imex:IM-12079-52 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006828.2|dip:DIP-34546N|ensembl:ENSG00000121022(gene)|ensembl:ENST00000357849(transcript)|go:"GO:0000338"(protein deneddylation)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006412"(translation)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019784"(NEDD8-specific protease activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0035718"(macrophage migration inhibitory factor binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070122"(isopeptidase activity)|go:"GO:1903894"(regulation of IRE1-mediated unfolded protein response)|go:"GO:1990182"(exosomal secretion)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR037518|interpro:IPR037740|interpro:IPR040961|mint:Q92905|rcsb pdb:4D10|rcsb pdb:4D18|rcsb pdb:4F7O|rcsb pdb:4WSN|rcsb pdb:5JOG|rcsb pdb:5JOH|rcsb pdb:5M5Q|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|reactome:R-HSA-5696394|reactome:R-HSA-6781823|reactome:R-HSA-8856825|reactome:R-HSA-8951664 ensembl:ENSG00000138663(gene)|refseq:NP_057213.2|refseq:NP_001244935.1|go:"GO:0016607"(nuclear speck)|go:"GO:0019784"(NEDD8-specific protease activity)|go:"GO:0030054"(cell junction)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR036388|interpro:IPR036390|interpro:IPR037754|interpro:IPR040134|interpro:IPR041406|mint:Q9BT78|rcsb pdb:4D0P|rcsb pdb:4D10|rcsb pdb:4D18|rcsb pdb:4WSN|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|rcsb pdb:6R7N|reactome:R-HSA-5696394|reactome:R-HSA-6781823|reactome:R-HSA-8856825|reactome:R-HSA-8951664|reactome:R-HSA-9013422|ensembl:ENST00000264389(transcript)|go:"GO:0000338"(protein deneddylation)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008180"(COP9 signalosome)|refseq:NP_001317656.1|dip:DIP-34516N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:GMgH8dW3KWILX6Mr/+XrgAV3xY49606 rogid:onrZiPzG+bZvycmpDTZMtkPzCfQ9606 intact-crc:62C682BFC2A95F82|rigid:idT5K7H/rzoG1Ge3VgtYYQZGUuo false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q92905 uniprotkb:Q92466 intact:EBI-594661|uniprotkb:O15386|uniprotkb:Q6AW95|uniprotkb:Q86WQ4|uniprotkb:Q9BQ17|ensembl:ENSP00000350512 intact:EBI-1176171|uniprotkb:Q76E54|uniprotkb:Q76E55|uniprotkb:Q76E56|uniprotkb:Q76E57|uniprotkb:B2R875|ensembl:ENSP00000256996 psi-mi:csn5_human(display_long)|uniprotkb:Jun activation domain-binding protein 1(gene name synonym)|uniprotkb:COPS5(gene name)|psi-mi:COPS5(display_short)|uniprotkb:CSN5(gene name synonym)|uniprotkb:JAB1(gene name synonym) psi-mi:ddb2_human(display_long)|uniprotkb:Damage-specific DNA-binding protein 2(gene name synonym)|uniprotkb:DDB p48 subunit(gene name synonym)|uniprotkb:UV-damaged DNA-binding protein 2(gene name synonym)|uniprotkb:DDB2(gene name)|psi-mi:DDB2(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510150|imex:IM-12079-52 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006828.2|dip:DIP-34546N|ensembl:ENSG00000121022(gene)|ensembl:ENST00000357849(transcript)|go:"GO:0000338"(protein deneddylation)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006412"(translation)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019784"(NEDD8-specific protease activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0035718"(macrophage migration inhibitory factor binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070122"(isopeptidase activity)|go:"GO:1903894"(regulation of IRE1-mediated unfolded protein response)|go:"GO:1990182"(exosomal secretion)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR037518|interpro:IPR037740|interpro:IPR040961|mint:Q92905|rcsb pdb:4D10|rcsb pdb:4D18|rcsb pdb:4F7O|rcsb pdb:4WSN|rcsb pdb:5JOG|rcsb pdb:5JOH|rcsb pdb:5M5Q|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|reactome:R-HSA-5696394|reactome:R-HSA-6781823|reactome:R-HSA-8856825|reactome:R-HSA-8951664 refseq:NP_000098.1|refseq:NP_001287663.1|ensembl:ENSG00000134574(gene)|ensembl:ENST00000256996(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0003677"(DNA binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006290"(pyrimidine dimer repair)|go:"GO:0009411"(response to UV)|go:"GO:0030054"(cell junction)|go:"GO:0031465"(Cul4B-RING E3 ubiquitin ligase complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035518"(histone H2A monoubiquitination)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0070914"(UV-damage excision repair)|go:"GO:0080008"(Cul4-RING E3 ubiquitin ligase complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR033312|interpro:IPR036322|rcsb pdb:3EI4|rcsb pdb:3I7L|rcsb pdb:4E54|rcsb pdb:4E5Z|rcsb pdb:6R8Y|rcsb pdb:6R8Z|rcsb pdb:6R90|rcsb pdb:6R91|rcsb pdb:6R92|reactome:R-HSA-5689880|reactome:R-HSA-5696394|reactome:R-HSA-5696395|reactome:R-HSA-5696400|reactome:R-HSA-6796648|reactome:R-HSA-8951664|dip:DIP-36670N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:GMgH8dW3KWILX6Mr/+XrgAV3xY49606 rogid:HkT35Q/boNG3Gc5ZH4PzTwrMebU9606 intact-crc:62C682BFC2A95F82|rigid:idT5K7H/rzoG1Ge3VgtYYQZGUuo false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q92905 uniprotkb:Q9P2J3 intact:EBI-594661|uniprotkb:O15386|uniprotkb:Q6AW95|uniprotkb:Q86WQ4|uniprotkb:Q9BQ17|ensembl:ENSP00000350512 intact:EBI-2510152|ensembl:ENSP00000351933|uniprotkb:Q8TCQ2 psi-mi:csn5_human(display_long)|uniprotkb:Jun activation domain-binding protein 1(gene name synonym)|uniprotkb:COPS5(gene name)|psi-mi:COPS5(display_short)|uniprotkb:CSN5(gene name synonym)|uniprotkb:JAB1(gene name synonym) psi-mi:klhl9_human(display_long)|uniprotkb:KLHL9(gene name)|psi-mi:KLHL9(display_short)|uniprotkb:KIAA1354(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510150|imex:IM-12079-52 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006828.2|dip:DIP-34546N|ensembl:ENSG00000121022(gene)|ensembl:ENST00000357849(transcript)|go:"GO:0000338"(protein deneddylation)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006412"(translation)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019784"(NEDD8-specific protease activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0035718"(macrophage migration inhibitory factor binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070122"(isopeptidase activity)|go:"GO:1903894"(regulation of IRE1-mediated unfolded protein response)|go:"GO:1990182"(exosomal secretion)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR037518|interpro:IPR037740|interpro:IPR040961|mint:Q92905|rcsb pdb:4D10|rcsb pdb:4D18|rcsb pdb:4F7O|rcsb pdb:4WSN|rcsb pdb:5JOG|rcsb pdb:5JOH|rcsb pdb:5M5Q|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|reactome:R-HSA-5696394|reactome:R-HSA-6781823|reactome:R-HSA-8856825|reactome:R-HSA-8951664 ensembl:ENSG00000198642(gene)|ensembl:ENST00000359039(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0007049"(cell cycle)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030496"(midbody)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0051301"(cell division)|go:"GO:0097602"(cullin family protein binding)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR011705(BTB/Kelch-associated)|interpro:IPR015915(Kelch-type beta propeller)|interpro:IPR017096(Kelch-like protein, gigaxonin)|reactome:R-HSA-8951664|reactome:R-HSA-983168|refseq:NP_061335.1|dip:DIP-53514N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:GMgH8dW3KWILX6Mr/+XrgAV3xY49606 rogid:BBlUawWo6f4qKrbRHeZp87E+DTo9606 intact-crc:62C682BFC2A95F82|rigid:idT5K7H/rzoG1Ge3VgtYYQZGUuo false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q92905 uniprotkb:Q9UBW8 intact:EBI-594661|uniprotkb:O15386|uniprotkb:Q6AW95|uniprotkb:Q86WQ4|uniprotkb:Q9BQ17|ensembl:ENSP00000350512 intact:EBI-712982|ensembl:ENSP00000229251|ensembl:ENSP00000438115|ensembl:ENSP00000438363|ensembl:ENSP00000441852|ensembl:ENSP00000446039|uniprotkb:Q9NVX3|uniprotkb:Q9UJW4|uniprotkb:A8K9A6 psi-mi:csn5_human(display_long)|uniprotkb:Jun activation domain-binding protein 1(gene name synonym)|uniprotkb:COPS5(gene name)|psi-mi:COPS5(display_short)|uniprotkb:CSN5(gene name synonym)|uniprotkb:JAB1(gene name synonym) psi-mi:csn7a_human(display_long)|uniprotkb:JAB1-containing signalosome subunit 7a(gene name synonym)|uniprotkb:Dermal papilla-derived protein 10(gene name synonym)|uniprotkb:COPS7A(gene name)|psi-mi:COPS7A(display_short)|uniprotkb:CSN7A(gene name synonym)|uniprotkb:DERP10(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510150|imex:IM-12079-52 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006828.2|dip:DIP-34546N|ensembl:ENSG00000121022(gene)|ensembl:ENST00000357849(transcript)|go:"GO:0000338"(protein deneddylation)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006412"(translation)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019784"(NEDD8-specific protease activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0035718"(macrophage migration inhibitory factor binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070122"(isopeptidase activity)|go:"GO:1903894"(regulation of IRE1-mediated unfolded protein response)|go:"GO:1990182"(exosomal secretion)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR037518|interpro:IPR037740|interpro:IPR040961|mint:Q92905|rcsb pdb:4D10|rcsb pdb:4D18|rcsb pdb:4F7O|rcsb pdb:4WSN|rcsb pdb:5JOG|rcsb pdb:5JOH|rcsb pdb:5M5Q|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|reactome:R-HSA-5696394|reactome:R-HSA-6781823|reactome:R-HSA-8856825|reactome:R-HSA-8951664 ensembl:ENSG00000111652(gene)|ensembl:ENST00000229251(transcript)|ensembl:ENST00000534877(transcript)|ensembl:ENST00000534947(transcript)|ensembl:ENST00000539735(transcript)|ensembl:ENST00000543155(transcript)|go:"GO:0000338"(protein deneddylation)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010387"(COP9 signalosome assembly)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR037757|interpro:IPR041481|mint:Q9UBW8|rcsb pdb:4D10|rcsb pdb:4D18|rcsb pdb:4WSN|reactome:R-HSA-5696394|reactome:R-HSA-6781823|reactome:R-HSA-8856825|reactome:R-HSA-8951664|refseq:NP_001157565.1|refseq:NP_001157566.1|refseq:NP_001157567.1|refseq:NP_057403.1|refseq:XP_005253751.1|dip:DIP-53412N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:GMgH8dW3KWILX6Mr/+XrgAV3xY49606 rogid:KT1zw5OuZthyscvNa/4lW1iJz2Q9606 intact-crc:62C682BFC2A95F82|rigid:idT5K7H/rzoG1Ge3VgtYYQZGUuo false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q92905 uniprotkb:P15374 intact:EBI-594661|uniprotkb:O15386|uniprotkb:Q6AW95|uniprotkb:Q86WQ4|uniprotkb:Q9BQ17|ensembl:ENSP00000350512 intact:EBI-954554|uniprotkb:Q5TBK8|uniprotkb:Q6IBE9|ensembl:ENSP00000366819|uniprotkb:B2R970 psi-mi:csn5_human(display_long)|uniprotkb:Jun activation domain-binding protein 1(gene name synonym)|uniprotkb:COPS5(gene name)|psi-mi:COPS5(display_short)|uniprotkb:CSN5(gene name synonym)|uniprotkb:JAB1(gene name synonym) psi-mi:uchl3_human(display_long)|uniprotkb:Ubiquitin thioesterase L3(gene name synonym)|uniprotkb:UCHL3(gene name)|psi-mi:UCHL3(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510150|imex:IM-12079-52 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006828.2|dip:DIP-34546N|ensembl:ENSG00000121022(gene)|ensembl:ENST00000357849(transcript)|go:"GO:0000338"(protein deneddylation)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006412"(translation)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019784"(NEDD8-specific protease activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0035718"(macrophage migration inhibitory factor binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070122"(isopeptidase activity)|go:"GO:1903894"(regulation of IRE1-mediated unfolded protein response)|go:"GO:1990182"(exosomal secretion)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR037518|interpro:IPR037740|interpro:IPR040961|mint:Q92905|rcsb pdb:4D10|rcsb pdb:4D18|rcsb pdb:4F7O|rcsb pdb:4WSN|rcsb pdb:5JOG|rcsb pdb:5JOH|rcsb pdb:5M5Q|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|reactome:R-HSA-5696394|reactome:R-HSA-6781823|reactome:R-HSA-8856825|reactome:R-HSA-8951664 refseq:NP_001257881.1|refseq:NP_005993.1|ensembl:ENSG00000118939(gene)|ensembl:ENST00000377595(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008233"(peptidase activity)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019784"(NEDD8-specific protease activity)|go:"GO:0030163"(protein catabolic process)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043687"(post-translational protein modification)|interpro:IPR001578(Peptidase C12, ubiquitin carboxyl-terminal hydrolase 1)|interpro:IPR036959|interpro:IPR038765|rcsb pdb:1UCH|rcsb pdb:1XD3|rcsb pdb:6ISU|rcsb pdb:6QML|reactome:R-HSA-5689603|reactome:R-HSA-8866652|reactome:R-HSA-8951664|dip:DIP-29135N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:GMgH8dW3KWILX6Mr/+XrgAV3xY49606 rogid:cPnctBpxrgvBKBSaQmhCsyd2nRM9606 intact-crc:62C682BFC2A95F82|rigid:idT5K7H/rzoG1Ge3VgtYYQZGUuo false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q92905 uniprotkb:Q13616 intact:EBI-594661|uniprotkb:O15386|uniprotkb:Q6AW95|uniprotkb:Q86WQ4|uniprotkb:Q9BQ17|ensembl:ENSP00000350512 intact:EBI-359390|uniprotkb:O60719|uniprotkb:Q08AL6|uniprotkb:Q8IYW1|uniprotkb:D3DWG3|ensembl:ENSP00000326804|ensembl:ENSP00000387160|ensembl:ENSP00000473318|ensembl:ENSP00000499255|ensembl:ENSP00000499277|ensembl:ENSP00000499398 psi-mi:csn5_human(display_long)|uniprotkb:Jun activation domain-binding protein 1(gene name synonym)|uniprotkb:COPS5(gene name)|psi-mi:COPS5(display_short)|uniprotkb:CSN5(gene name synonym)|uniprotkb:JAB1(gene name synonym) psi-mi:cul1_human(display_long)|uniprotkb:CUL1(gene name)|psi-mi:CUL1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510150|imex:IM-12079-52 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006828.2|dip:DIP-34546N|ensembl:ENSG00000121022(gene)|ensembl:ENST00000357849(transcript)|go:"GO:0000338"(protein deneddylation)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006412"(translation)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019784"(NEDD8-specific protease activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0035718"(macrophage migration inhibitory factor binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070122"(isopeptidase activity)|go:"GO:1903894"(regulation of IRE1-mediated unfolded protein response)|go:"GO:1990182"(exosomal secretion)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR037518|interpro:IPR037740|interpro:IPR040961|mint:Q92905|rcsb pdb:4D10|rcsb pdb:4D18|rcsb pdb:4F7O|rcsb pdb:4WSN|rcsb pdb:5JOG|rcsb pdb:5JOH|rcsb pdb:5M5Q|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|reactome:R-HSA-5696394|reactome:R-HSA-6781823|reactome:R-HSA-8856825|reactome:R-HSA-8951664 refseq:NP_003583.2|rcsb pdb:6WCQ|rcsb pdb:7B5L|rcsb pdb:7B5M|rcsb pdb:7B5N|rcsb pdb:7B5R|rcsb pdb:7B5S|reactome:R-HSA-1169091|reactome:R-HSA-1170546|reactome:R-HSA-174113|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-2122947|reactome:R-HSA-2565942|reactome:R-HSA-2644606|reactome:R-HSA-2644607|reactome:R-HSA-2871837|reactome:R-HSA-2894862|reactome:R-HSA-400253|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5676590|reactome:R-HSA-5684264|reactome:R-HSA-68949|reactome:R-HSA-69231|reactome:R-HSA-8854050|reactome:R-HSA-8939902|reactome:R-HSA-8951664|reactome:R-HSA-9020702|reactome:R-HSA-917937|reactome:R-HSA-9604323|reactome:R-HSA-9708530|reactome:R-HSA-983168|refseq:XP_011514931.1|refseq:XP_011514932.1|refseq:XP_011514933.1|refseq:XP_011514934.1|ensembl:ENSG00000055130(gene)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|ensembl:ENST00000325222(transcript)|ensembl:ENST00000409469(transcript)|ensembl:ENST00000602748(transcript)|ensembl:ENST00000662716(transcript)|ensembl:ENST00000663044(transcript)|ensembl:ENST00000665936(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:1990452"(Parkin-FBXW7-Cul1 ubiquitin ligase complex)|interpro:IPR001373(Cullin, N-terminal region)|interpro:IPR016157(Cullin, conserved site)|interpro:IPR016158(Cullin homology)|interpro:IPR016159(Cullin repeat-like)|interpro:IPR019559|interpro:IPR036317|interpro:IPR036388|interpro:IPR036390|mint:Q13616|rcsb pdb:1LDJ|rcsb pdb:1LDK|rcsb pdb:1U6G|rcsb pdb:3RTR|rcsb pdb:3TDU|rcsb pdb:3TDZ|rcsb pdb:4F52|rcsb pdb:4P5O|rcsb pdb:5V89|rcsb pdb:6TTU|refseq:XP_005250117.1|dip:DIP-17013N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:GMgH8dW3KWILX6Mr/+XrgAV3xY49606 rogid:OAZP+ifWW3eEnQKb937ww9s1fMQ9606 intact-crc:62C682BFC2A95F82|rigid:idT5K7H/rzoG1Ge3VgtYYQZGUuo false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q92905 uniprotkb:Q7L5N1 intact:EBI-594661|uniprotkb:O15386|uniprotkb:Q6AW95|uniprotkb:Q86WQ4|uniprotkb:Q9BQ17|ensembl:ENSP00000350512 intact:EBI-486838|uniprotkb:O15387|uniprotkb:A4D2A3|ensembl:ENSP00000304102 psi-mi:csn5_human(display_long)|uniprotkb:Jun activation domain-binding protein 1(gene name synonym)|uniprotkb:COPS5(gene name)|psi-mi:COPS5(display_short)|uniprotkb:CSN5(gene name synonym)|uniprotkb:JAB1(gene name synonym) psi-mi:csn6_human(display_long)|uniprotkb:COPS6(gene name)|psi-mi:COPS6(display_short)|uniprotkb:CSN6(gene name synonym)|uniprotkb:HVIP(gene name synonym)|uniprotkb:JAB1-containing signalosome subunit 6(gene name synonym)|uniprotkb:Vpr-interacting protein(gene name synonym)|uniprotkb:MOV34 homolog(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510150|imex:IM-12079-52 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006828.2|dip:DIP-34546N|ensembl:ENSG00000121022(gene)|ensembl:ENST00000357849(transcript)|go:"GO:0000338"(protein deneddylation)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006412"(translation)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019784"(NEDD8-specific protease activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0035718"(macrophage migration inhibitory factor binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070122"(isopeptidase activity)|go:"GO:1903894"(regulation of IRE1-mediated unfolded protein response)|go:"GO:1990182"(exosomal secretion)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR037518|interpro:IPR037740|interpro:IPR040961|mint:Q92905|rcsb pdb:4D10|rcsb pdb:4D18|rcsb pdb:4F7O|rcsb pdb:4WSN|rcsb pdb:5JOG|rcsb pdb:5JOH|rcsb pdb:5M5Q|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|reactome:R-HSA-5696394|reactome:R-HSA-6781823|reactome:R-HSA-8856825|reactome:R-HSA-8951664 refseq:NP_006824.2|ensembl:ENSG00000168090(gene)|ensembl:ENST00000303904(transcript)|go:"GO:0000338"(protein deneddylation)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070122"(isopeptidase activity)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR033859|interpro:IPR024969|interpro:IPR037518|mint:Q7L5N1|rcsb pdb:4D10|rcsb pdb:4D18|rcsb pdb:4QFT|rcsb pdb:4R14|rcsb pdb:4WSN|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|reactome:R-HSA-5696394|reactome:R-HSA-6781823|reactome:R-HSA-8856825|reactome:R-HSA-8951664|dip:DIP-32655N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:GMgH8dW3KWILX6Mr/+XrgAV3xY49606 rogid:hyuYyAujJCJtbfS2tJ+UgH7jWP89606 intact-crc:62C682BFC2A95F82|rigid:idT5K7H/rzoG1Ge3VgtYYQZGUuo false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q92905 uniprotkb:Q99627 intact:EBI-594661|uniprotkb:O15386|uniprotkb:Q6AW95|uniprotkb:Q86WQ4|uniprotkb:Q9BQ17|ensembl:ENSP00000350512 intact:EBI-2510102|ensembl:ENSP00000346340|uniprotkb:A8K1H6|uniprotkb:Q53QS9 psi-mi:csn5_human(display_long)|uniprotkb:Jun activation domain-binding protein 1(gene name synonym)|uniprotkb:COPS5(gene name)|psi-mi:COPS5(display_short)|uniprotkb:CSN5(gene name synonym)|uniprotkb:JAB1(gene name synonym) psi-mi:csn8_human(display_long)|uniprotkb:COPS8(gene name)|psi-mi:COPS8(display_short)|uniprotkb:CSN8(gene name synonym)|uniprotkb:JAB1-containing signalosome subunit 8(gene name synonym)|uniprotkb:COP9 homolog(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510150|imex:IM-12079-52 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006828.2|dip:DIP-34546N|ensembl:ENSG00000121022(gene)|ensembl:ENST00000357849(transcript)|go:"GO:0000338"(protein deneddylation)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006412"(translation)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019784"(NEDD8-specific protease activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0035718"(macrophage migration inhibitory factor binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070122"(isopeptidase activity)|go:"GO:1903894"(regulation of IRE1-mediated unfolded protein response)|go:"GO:1990182"(exosomal secretion)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR037518|interpro:IPR037740|interpro:IPR040961|mint:Q92905|rcsb pdb:4D10|rcsb pdb:4D18|rcsb pdb:4F7O|rcsb pdb:4WSN|rcsb pdb:5JOG|rcsb pdb:5JOH|rcsb pdb:5M5Q|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|reactome:R-HSA-5696394|reactome:R-HSA-6781823|reactome:R-HSA-8856825|reactome:R-HSA-8951664 ensembl:ENSG00000198612(gene)|ensembl:ENST00000354371(transcript)|go:"GO:0000338"(protein deneddylation)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010387"(COP9 signalosome assembly)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR033205|interpro:IPR033464|mint:Q99627|rcsb pdb:4D10|rcsb pdb:4D18|rcsb pdb:4WSN|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|rcsb pdb:6R7N|reactome:R-HSA-5696394|reactome:R-HSA-6781823|reactome:R-HSA-8856825|reactome:R-HSA-8951664|go:"GO:0006468"(protein phosphorylation)|refseq:NP_006701.1|refseq:NP_937832.1|dip:DIP-42075N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:GMgH8dW3KWILX6Mr/+XrgAV3xY49606 rogid:3L+8IdjEw+ZC5MERztdPAY2ww389606 intact-crc:62C682BFC2A95F82|rigid:idT5K7H/rzoG1Ge3VgtYYQZGUuo false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q92905 uniprotkb:Q8NEZ5 intact:EBI-594661|uniprotkb:O15386|uniprotkb:Q6AW95|uniprotkb:Q86WQ4|uniprotkb:Q9BQ17|ensembl:ENSP00000350512 intact:EBI-2510137|ensembl:ENSP00000307833|uniprotkb:Q9H824|uniprotkb:Q6PIL5|uniprotkb:Q9UKC0|uniprotkb:Q0D2P8|uniprotkb:Q8IXW3 psi-mi:csn5_human(display_long)|uniprotkb:Jun activation domain-binding protein 1(gene name synonym)|uniprotkb:COPS5(gene name)|psi-mi:COPS5(display_short)|uniprotkb:CSN5(gene name synonym)|uniprotkb:JAB1(gene name synonym) psi-mi:fbx22_human(display_long)|uniprotkb:FBXO22(gene name)|psi-mi:FBXO22(display_short)|uniprotkb:FBX22(gene name synonym)|uniprotkb:F-box protein FBX22p44(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510150|imex:IM-12079-52 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006828.2|dip:DIP-34546N|ensembl:ENSG00000121022(gene)|ensembl:ENST00000357849(transcript)|go:"GO:0000338"(protein deneddylation)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006412"(translation)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019784"(NEDD8-specific protease activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0035718"(macrophage migration inhibitory factor binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070122"(isopeptidase activity)|go:"GO:1903894"(regulation of IRE1-mediated unfolded protein response)|go:"GO:1990182"(exosomal secretion)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR037518|interpro:IPR037740|interpro:IPR040961|mint:Q92905|rcsb pdb:4D10|rcsb pdb:4D18|rcsb pdb:4F7O|rcsb pdb:4WSN|rcsb pdb:5JOG|rcsb pdb:5JOH|rcsb pdb:5M5Q|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|reactome:R-HSA-5696394|reactome:R-HSA-6781823|reactome:R-HSA-8856825|reactome:R-HSA-8951664 ensembl:ENSG00000167196(gene)|ensembl:ENST00000308275(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0030018"(Z disc)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR019494|interpro:IPR036047|reactome:R-HSA-8951664|reactome:R-HSA-983168|refseq:XP_011519749.1|refseq:NP_036302.1|refseq:NP_671717.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:GMgH8dW3KWILX6Mr/+XrgAV3xY49606 rogid:hOnBb3SK/OM+oGU8RdxmUb8MVDE9606 intact-crc:62C682BFC2A95F82|rigid:idT5K7H/rzoG1Ge3VgtYYQZGUuo false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q92905 uniprotkb:Q6TFL4 intact:EBI-594661|uniprotkb:O15386|uniprotkb:Q6AW95|uniprotkb:Q86WQ4|uniprotkb:Q9BQ17|ensembl:ENSP00000350512 intact:EBI-2510117|intact:EBI-28976209|ensembl:ENSP00000242810|ensembl:ENSP00000395012|uniprotkb:A5PLN8|uniprotkb:Q9H620|uniprotkb:Q9NXT9 psi-mi:csn5_human(display_long)|uniprotkb:Jun activation domain-binding protein 1(gene name synonym)|uniprotkb:COPS5(gene name)|psi-mi:COPS5(display_short)|uniprotkb:CSN5(gene name synonym)|uniprotkb:JAB1(gene name synonym) psi-mi:klh24_human(display_long)|uniprotkb:KLHL24(gene name)|psi-mi:KLHL24(display_short)|uniprotkb:DRE1(gene name synonym)|uniprotkb:Kainate receptor-interacting protein for GluR6(gene name synonym)|uniprotkb:Protein DRE1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510150|imex:IM-12079-52 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006828.2|dip:DIP-34546N|ensembl:ENSG00000121022(gene)|ensembl:ENST00000357849(transcript)|go:"GO:0000338"(protein deneddylation)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006412"(translation)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019784"(NEDD8-specific protease activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0035718"(macrophage migration inhibitory factor binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070122"(isopeptidase activity)|go:"GO:1903894"(regulation of IRE1-mediated unfolded protein response)|go:"GO:1990182"(exosomal secretion)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR037518|interpro:IPR037740|interpro:IPR040961|mint:Q92905|rcsb pdb:4D10|rcsb pdb:4D18|rcsb pdb:4F7O|rcsb pdb:4WSN|rcsb pdb:5JOG|rcsb pdb:5JOH|rcsb pdb:5M5Q|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|reactome:R-HSA-5696394|reactome:R-HSA-6781823|reactome:R-HSA-8856825|reactome:R-HSA-8951664 ensembl:ENSG00000114796(gene)|ensembl:ENST00000242810(transcript)|ensembl:ENST00000454652(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005912"(adherens junction)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030057"(desmosome)|go:"GO:0030424"(axon)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0043204"(perikaryon)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:2000312"(regulation of kainate selective glutamate receptor activity)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR011705(BTB/Kelch-associated)|interpro:IPR015915(Kelch-type beta propeller)|interpro:IPR017096(Kelch-like protein, gigaxonin)|interpro:IPR030596|ensembl:ENSP00000242810|ensembl:ENSP00000395012|ensembl:ENST00000476808|ensembl:ENSP00000419010|refseq:XP_011511240.1|refseq:NP_060114.2|refseq:XP_005247609.1|refseq:XP_005247610.1|refseq:XP_005247611.1|refseq:XP_005247612.1|refseq:XP_005247613.1|refseq:XP_016862148.1|refseq:XP_016862149.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:GMgH8dW3KWILX6Mr/+XrgAV3xY49606 rogid:bzDmcJFRhPoULz94KRhkDrQg+Bk9606 intact-crc:62C682BFC2A95F82|rigid:idT5K7H/rzoG1Ge3VgtYYQZGUuo false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q92905 uniprotkb:Q9H9Q2 intact:EBI-594661|uniprotkb:O15386|uniprotkb:Q6AW95|uniprotkb:Q86WQ4|uniprotkb:Q9BQ17|ensembl:ENSP00000350512 intact:EBI-2510162|ensembl:ENSP00000272995|ensembl:ENSP00000386567|uniprotkb:Q53S22|uniprotkb:Q5BJG3|uniprotkb:Q9H7V6 psi-mi:csn5_human(display_long)|uniprotkb:Jun activation domain-binding protein 1(gene name synonym)|uniprotkb:COPS5(gene name)|psi-mi:COPS5(display_short)|uniprotkb:CSN5(gene name synonym)|uniprotkb:JAB1(gene name synonym) psi-mi:csn7b_human(display_long)|uniprotkb:COPS7B(gene name)|psi-mi:COPS7B(display_short)|uniprotkb:CSN7B(gene name synonym)|uniprotkb:JAB1-containing signalosome subunit 7b(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510150|imex:IM-12079-52 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006828.2|dip:DIP-34546N|ensembl:ENSG00000121022(gene)|ensembl:ENST00000357849(transcript)|go:"GO:0000338"(protein deneddylation)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006412"(translation)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019784"(NEDD8-specific protease activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0035718"(macrophage migration inhibitory factor binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070122"(isopeptidase activity)|go:"GO:1903894"(regulation of IRE1-mediated unfolded protein response)|go:"GO:1990182"(exosomal secretion)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR037518|interpro:IPR037740|interpro:IPR040961|mint:Q92905|rcsb pdb:4D10|rcsb pdb:4D18|rcsb pdb:4F7O|rcsb pdb:4WSN|rcsb pdb:5JOG|rcsb pdb:5JOH|rcsb pdb:5M5Q|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|reactome:R-HSA-5696394|reactome:R-HSA-6781823|reactome:R-HSA-8856825|reactome:R-HSA-8951664 refseq:NP_001269879.1|refseq:NP_001269881.1|ensembl:ENSG00000144524(gene)|ensembl:ENST00000350033(transcript)|ensembl:ENST00000410024(transcript)|go:"GO:0000338"(protein deneddylation)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010387"(COP9 signalosome assembly)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR041481|mint:Q9H9Q2|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|interpro:IPR027530|rcsb pdb:6R7I|rcsb pdb:6R7N|reactome:R-HSA-5696394|reactome:R-HSA-6781823|reactome:R-HSA-8856825|reactome:R-HSA-8951664|refseq:NP_073567.1|refseq:XP_016860205.1|refseq:XP_016860206.1|dip:DIP-53525N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:GMgH8dW3KWILX6Mr/+XrgAV3xY49606 rogid:Q4rrTMRm/aOT/uIBaELCKNCZd9c9606 intact-crc:62C682BFC2A95F82|rigid:idT5K7H/rzoG1Ge3VgtYYQZGUuo false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q92905 uniprotkb:Q8TEB1 intact:EBI-594661|uniprotkb:O15386|uniprotkb:Q6AW95|uniprotkb:Q86WQ4|uniprotkb:Q9BQ17|ensembl:ENSP00000350512 intact:EBI-2213388|uniprotkb:Q5D039|uniprotkb:Q86U00|uniprotkb:Q86U39|uniprotkb:Q8NDN2|uniprotkb:Q9H2J0|uniprotkb:Q9H3A3|uniprotkb:Q9H5C9|uniprotkb:D3DS56|uniprotkb:B3KQ83|ensembl:ENSP00000415556|ensembl:ENSP00000452898|ensembl:ENSP00000494282|ensembl:ENSP00000495416 psi-mi:csn5_human(display_long)|uniprotkb:Jun activation domain-binding protein 1(gene name synonym)|uniprotkb:COPS5(gene name)|psi-mi:COPS5(display_short)|uniprotkb:CSN5(gene name synonym)|uniprotkb:JAB1(gene name synonym) psi-mi:dca11_human(display_long)|uniprotkb:DCAF11(gene name)|psi-mi:DCAF11(display_short)|uniprotkb:GL014(orf name)|uniprotkb:PRO2389(orf name)|uniprotkb:WDR23(gene name synonym)|uniprotkb:WD repeat-containing protein 23(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510150|imex:IM-12079-52 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006828.2|dip:DIP-34546N|ensembl:ENSG00000121022(gene)|ensembl:ENST00000357849(transcript)|go:"GO:0000338"(protein deneddylation)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006412"(translation)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019784"(NEDD8-specific protease activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0035718"(macrophage migration inhibitory factor binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070122"(isopeptidase activity)|go:"GO:1903894"(regulation of IRE1-mediated unfolded protein response)|go:"GO:1990182"(exosomal secretion)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR037518|interpro:IPR037740|interpro:IPR040961|mint:Q92905|rcsb pdb:4D10|rcsb pdb:4D18|rcsb pdb:4F7O|rcsb pdb:4WSN|rcsb pdb:5JOG|rcsb pdb:5JOH|rcsb pdb:5M5Q|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|reactome:R-HSA-5696394|reactome:R-HSA-6781823|reactome:R-HSA-8856825|reactome:R-HSA-8951664 refseq:NP_001156956.1|refseq:NP_079506.3|refseq:NP_852002.1|ensembl:ENSG00000100897(gene)|ensembl:ENSG00000284796(gene)|ensembl:ENST00000446197(transcript)|ensembl:ENST00000559115(transcript)|ensembl:ENST00000642239(transcript)|ensembl:ENST00000646568(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0080008"(Cul4-RING E3 ubiquitin ligase complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR017399(WD repeat protein 23)|interpro:IPR020472|interpro:IPR036322|mint:Q8TEB1|reactome:R-HSA-8951664 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:GMgH8dW3KWILX6Mr/+XrgAV3xY49606 rogid:iQQ4lP7NSE1MIcskh1XBjj9CC0s9606 intact-crc:62C682BFC2A95F82|rigid:idT5K7H/rzoG1Ge3VgtYYQZGUuo false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q92905 uniprotkb:Q13619 intact:EBI-594661|uniprotkb:O15386|uniprotkb:Q6AW95|uniprotkb:Q86WQ4|uniprotkb:Q9BQ17|ensembl:ENSP00000350512 intact:EBI-456106|uniprotkb:O75834|uniprotkb:Q589T6|uniprotkb:Q5TC62|uniprotkb:Q6UP08|uniprotkb:Q9UP17|uniprotkb:A2A2W2|ensembl:ENSP00000364589 psi-mi:csn5_human(display_long)|uniprotkb:Jun activation domain-binding protein 1(gene name synonym)|uniprotkb:COPS5(gene name)|psi-mi:COPS5(display_short)|uniprotkb:CSN5(gene name synonym)|uniprotkb:JAB1(gene name synonym) psi-mi:cul4a_human(display_long)|uniprotkb:CUL4A(gene name)|psi-mi:CUL4A(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510150|imex:IM-12079-52 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006828.2|dip:DIP-34546N|ensembl:ENSG00000121022(gene)|ensembl:ENST00000357849(transcript)|go:"GO:0000338"(protein deneddylation)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006412"(translation)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019784"(NEDD8-specific protease activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0035718"(macrophage migration inhibitory factor binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070122"(isopeptidase activity)|go:"GO:1903894"(regulation of IRE1-mediated unfolded protein response)|go:"GO:1990182"(exosomal secretion)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR037518|interpro:IPR037740|interpro:IPR040961|mint:Q92905|rcsb pdb:4D10|rcsb pdb:4D18|rcsb pdb:4F7O|rcsb pdb:4WSN|rcsb pdb:5JOG|rcsb pdb:5JOH|rcsb pdb:5M5Q|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|reactome:R-HSA-5696394|reactome:R-HSA-6781823|reactome:R-HSA-8856825|reactome:R-HSA-8951664 refseq:NP_001008895.1|refseq:NP_003580.1|refseq:NP_001265442.1|refseq:XP_011535825.1|dip:DIP-31610N|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042254"(ribosome biogenesis)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0048511"(rhythmic process)|go:"GO:0051246"(regulation of protein metabolic process)|go:"GO:0080008"(Cul4-RING E3 ubiquitin ligase complex)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000001"(regulation of DNA damage checkpoint)|go:"GO:2000819"(regulation of nucleotide-excision repair)|interpro:IPR001373(Cullin, N-terminal region)|interpro:IPR016157(Cullin, conserved site)|interpro:IPR016158(Cullin homology)|interpro:IPR016159(Cullin repeat-like)|interpro:IPR019559|interpro:IPR036317|interpro:IPR036388|interpro:IPR036390|mint:Q13619|rcsb pdb:2HYE|rcsb pdb:4A0K|reactome:R-HSA-110314|reactome:R-HSA-5696394|reactome:R-HSA-5696395|reactome:R-HSA-5696400|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-8951664|ensembl:ENSG00000139842(gene)|ensembl:ENST00000375440(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030853"(negative regulation of granulocyte differentiation)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031464"(Cul4A-RING E3 ubiquitin ligase complex) psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:GMgH8dW3KWILX6Mr/+XrgAV3xY49606 rogid:xYRRxjpO/9qqeXtq9dfACAdqyM89606 intact-crc:62C682BFC2A95F82|rigid:idT5K7H/rzoG1Ge3VgtYYQZGUuo false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q92905 uniprotkb:Q13309 intact:EBI-594661|uniprotkb:O15386|uniprotkb:Q6AW95|uniprotkb:Q86WQ4|uniprotkb:Q9BQ17|ensembl:ENSP00000350512 intact:EBI-456291|uniprotkb:Q8TDZ0|uniprotkb:Q8TDZ1|uniprotkb:Q9BV69|ensembl:ENSP00000274255|uniprotkb:A8K5E0|uniprotkb:B4DJT4 psi-mi:csn5_human(display_long)|uniprotkb:Jun activation domain-binding protein 1(gene name synonym)|uniprotkb:COPS5(gene name)|psi-mi:COPS5(display_short)|uniprotkb:CSN5(gene name synonym)|uniprotkb:JAB1(gene name synonym) psi-mi:skp2_human(display_long)|uniprotkb:F-box protein Skp2(gene name synonym)|uniprotkb:Cyclin-A/CDK2-associated protein p45(gene name synonym)|uniprotkb:p45skp2(gene name synonym)|uniprotkb:F-box/LRR-repeat protein 1(gene name synonym)|uniprotkb:SKP2(gene name)|psi-mi:SKP2(display_short)|uniprotkb:FBXL1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510150|imex:IM-12079-52 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006828.2|dip:DIP-34546N|ensembl:ENSG00000121022(gene)|ensembl:ENST00000357849(transcript)|go:"GO:0000338"(protein deneddylation)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006412"(translation)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019784"(NEDD8-specific protease activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0035718"(macrophage migration inhibitory factor binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070122"(isopeptidase activity)|go:"GO:1903894"(regulation of IRE1-mediated unfolded protein response)|go:"GO:1990182"(exosomal secretion)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR037518|interpro:IPR037740|interpro:IPR040961|mint:Q92905|rcsb pdb:4D10|rcsb pdb:4D18|rcsb pdb:4F7O|rcsb pdb:4WSN|rcsb pdb:5JOG|rcsb pdb:5JOH|rcsb pdb:5M5Q|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|reactome:R-HSA-5696394|reactome:R-HSA-6781823|reactome:R-HSA-8856825|reactome:R-HSA-8951664 ensembl:ENSG00000145604(gene)|ensembl:ENST00000274255(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0033148"(positive regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045087"(innate immune response)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0051607"(defense response to virus)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0071460"(cellular response to cell-matrix adhesion)|go:"GO:1902916"(positive regulation of protein polyubiquitination)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR006553(Leucine-rich repeat, cysteine-containing subtype)|rcsb pdb:2ASS|rcsb pdb:2AST|interpro:IPR032675|rcsb pdb:7B5L|interpro:IPR036047|mint:Q13309|rcsb pdb:1FQV|rcsb pdb:7B5M|rcsb pdb:1FS1|rcsb pdb:1FS2|rcsb pdb:1LDK|refseq:NP_005974.2|refseq:NP_116026.1|refseq:NP_001230049.1|dip:DIP-17011N|rcsb pdb:7B5R|reactome:R-HSA-174178|reactome:R-HSA-187577|reactome:R-HSA-5689880|reactome:R-HSA-68949|reactome:R-HSA-69231|reactome:R-HSA-8939902|reactome:R-HSA-8951664|reactome:R-HSA-9687136|reactome:R-HSA-9708530|reactome:R-HSA-983168 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:GMgH8dW3KWILX6Mr/+XrgAV3xY49606 rogid:VABxcX3qu0Yr6eRNYINqvAPhPMc9606 intact-crc:62C682BFC2A95F82|rigid:idT5K7H/rzoG1Ge3VgtYYQZGUuo false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q92905 uniprotkb:Q15843 intact:EBI-594661|uniprotkb:O15386|uniprotkb:Q6AW95|uniprotkb:Q86WQ4|uniprotkb:Q9BQ17|ensembl:ENSP00000350512 intact:EBI-716247|uniprotkb:Q3SXN8|uniprotkb:Q6LES6|ensembl:ENSP00000250495|ensembl:ENSP00000496420 psi-mi:csn5_human(display_long)|uniprotkb:Jun activation domain-binding protein 1(gene name synonym)|uniprotkb:COPS5(gene name)|psi-mi:COPS5(display_short)|uniprotkb:CSN5(gene name synonym)|uniprotkb:JAB1(gene name synonym) psi-mi:nedd8_human(display_long)|uniprotkb:Ubiquitin-like protein Nedd8(gene name synonym)|uniprotkb:Neddylin(gene name synonym)|uniprotkb:Neural precursor cell expressed developmentally down-regulated protein 8(gene name synonym)|uniprotkb:NEDD8(gene name)|psi-mi:NEDD8(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510150|imex:IM-12079-52 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006828.2|dip:DIP-34546N|ensembl:ENSG00000121022(gene)|ensembl:ENST00000357849(transcript)|go:"GO:0000338"(protein deneddylation)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006412"(translation)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019784"(NEDD8-specific protease activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0035718"(macrophage migration inhibitory factor binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070122"(isopeptidase activity)|go:"GO:1903894"(regulation of IRE1-mediated unfolded protein response)|go:"GO:1990182"(exosomal secretion)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR037518|interpro:IPR037740|interpro:IPR040961|mint:Q92905|rcsb pdb:4D10|rcsb pdb:4D18|rcsb pdb:4F7O|rcsb pdb:4WSN|rcsb pdb:5JOG|rcsb pdb:5JOH|rcsb pdb:5M5Q|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|reactome:R-HSA-5696394|reactome:R-HSA-6781823|reactome:R-HSA-8856825|reactome:R-HSA-8951664 refseq:NP_006147.1|ensembl:ENSG00000129559(gene)|ensembl:ENSG00000285246(gene)|ensembl:ENST00000250495(transcript)|ensembl:ENST00000643069(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006508"(proteolysis)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008104"(protein localization)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0019941"(modification-dependent protein catabolic process)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0031386"(protein tag)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0045116"(protein neddylation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000626(Ubiquitin)|interpro:IPR019954|interpro:IPR019956|interpro:IPR029071|interpro:IPR038738|mint:Q15843|rcsb pdb:1NDD|rcsb pdb:1R4M|rcsb pdb:1R4N|rcsb pdb:1XT9|rcsb pdb:2BKR|rcsb pdb:2KO3|rcsb pdb:2N7K|rcsb pdb:2NVU|rcsb pdb:3DBH|rcsb pdb:3DBL|rcsb pdb:3DBR|rcsb pdb:3DQV|rcsb pdb:3GZN|rcsb pdb:4F8C|rcsb pdb:4FBJ|rcsb pdb:4HCP|rcsb pdb:4P5O|rcsb pdb:6R7F|rcsb pdb:6R7I|rcsb pdb:6TTU|rcsb pdb:7B5L|rcsb pdb:7B5N|reactome:R-HSA-2173789|reactome:R-HSA-5689603|reactome:R-HSA-8856825|reactome:R-HSA-8951664|reactome:R-HSA-917937|dip:DIP-29266N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:GMgH8dW3KWILX6Mr/+XrgAV3xY49606 rogid:qB1KNoIOwa1ONfphWDWjJri9hwE9606 intact-crc:62C682BFC2A95F82|rigid:idT5K7H/rzoG1Ge3VgtYYQZGUuo false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q92905 uniprotkb:Q13618 intact:EBI-594661|uniprotkb:O15386|uniprotkb:Q6AW95|uniprotkb:Q86WQ4|uniprotkb:Q9BQ17|ensembl:ENSP00000350512 intact:EBI-456129|uniprotkb:O75415|uniprotkb:Q569L3|uniprotkb:Q9UBI8|uniprotkb:B8ZZC3|uniprotkb:Q9UET7|uniprotkb:A8K536|ensembl:ENSP00000264414 psi-mi:csn5_human(display_long)|uniprotkb:Jun activation domain-binding protein 1(gene name synonym)|uniprotkb:COPS5(gene name)|psi-mi:COPS5(display_short)|uniprotkb:CSN5(gene name synonym)|uniprotkb:JAB1(gene name synonym) psi-mi:cul3_human(display_long)|uniprotkb:CUL3(gene name)|psi-mi:CUL3(display_short)|uniprotkb:KIAA0617(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510150|imex:IM-12079-52 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006828.2|dip:DIP-34546N|ensembl:ENSG00000121022(gene)|ensembl:ENST00000357849(transcript)|go:"GO:0000338"(protein deneddylation)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006412"(translation)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019784"(NEDD8-specific protease activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0035718"(macrophage migration inhibitory factor binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070122"(isopeptidase activity)|go:"GO:1903894"(regulation of IRE1-mediated unfolded protein response)|go:"GO:1990182"(exosomal secretion)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR037518|interpro:IPR037740|interpro:IPR040961|mint:Q92905|rcsb pdb:4D10|rcsb pdb:4D18|rcsb pdb:4F7O|rcsb pdb:4WSN|rcsb pdb:5JOG|rcsb pdb:5JOH|rcsb pdb:5M5Q|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|reactome:R-HSA-5696394|reactome:R-HSA-6781823|reactome:R-HSA-8856825|reactome:R-HSA-8951664 refseq:NP_003581.1|refseq:NP_001244126.1|refseq:NP_001244127.1|dip:DIP-31611N|ensembl:ENSG00000036257(gene)|ensembl:ENST00000264414(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000922"(spindle pole)|go:"GO:0001831"(trophectodermal cellular morphogenesis)|go:"GO:0005112"(Notch binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005827"(polar microtubule)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007369"(gastrulation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016477"(cell migration)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0017145"(stem cell division)|go:"GO:0030030"(cell projection organization)|go:"GO:0030332"(cyclin binding)|go:"GO:0031145"(anaphase-promoting complex-dependent catabolic process)|go:"GO:0031208"(POZ domain binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0036126"(sperm flagellum)|go:"GO:0040016"(embryonic cleavage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044346"(fibroblast apoptotic process)|go:"GO:0045842"(positive regulation of mitotic metaphase/anaphase transition)|go:"GO:0048208"(COPII vesicle coating)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0071630"(nuclear protein quality control by the ubiquitin-proteasome system)|go:"GO:0072576"(liver morphogenesis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:1901992"(positive regulation of mitotic cell cycle phase transition)|interpro:IPR001373(Cullin, N-terminal region)|interpro:IPR016157(Cullin, conserved site)|interpro:IPR016158(Cullin homology)|interpro:IPR016159(Cullin repeat-like)|interpro:IPR019559|interpro:IPR036317|interpro:IPR036388|interpro:IPR036390|mint:Q13618|rcsb pdb:2MYL|rcsb pdb:2MYM|rcsb pdb:4AP2|rcsb pdb:4APF|rcsb pdb:4EOZ|rcsb pdb:4HXI|rcsb pdb:5NLB|rcsb pdb:6I2M|reactome:R-HSA-4641258|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-8932339|reactome:R-HSA-8951664|reactome:R-HSA-9013418|reactome:R-HSA-9013422|reactome:R-HSA-9706019|reactome:R-HSA-983168 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:GMgH8dW3KWILX6Mr/+XrgAV3xY49606 rogid:xI/8pHB9nckOW629STOqKba4KzQ9606 intact-crc:62C682BFC2A95F82|rigid:idT5K7H/rzoG1Ge3VgtYYQZGUuo false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q92905 uniprotkb:Q15048 intact:EBI-594661|uniprotkb:O15386|uniprotkb:Q6AW95|uniprotkb:Q86WQ4|uniprotkb:Q9BQ17|ensembl:ENSP00000350512 intact:EBI-2510124|ensembl:ENSP00000292524|ensembl:ENSP00000434768|uniprotkb:A8K0A8|uniprotkb:D3DWM8 psi-mi:csn5_human(display_long)|uniprotkb:Jun activation domain-binding protein 1(gene name synonym)|uniprotkb:COPS5(gene name)|psi-mi:COPS5(display_short)|uniprotkb:CSN5(gene name synonym)|uniprotkb:JAB1(gene name synonym) psi-mi:lrc14_human(display_long)|uniprotkb:LRRC14(gene name)|psi-mi:LRRC14(display_short)|uniprotkb:KIAA0014(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510150|imex:IM-12079-52 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006828.2|dip:DIP-34546N|ensembl:ENSG00000121022(gene)|ensembl:ENST00000357849(transcript)|go:"GO:0000338"(protein deneddylation)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006412"(translation)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019784"(NEDD8-specific protease activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0035718"(macrophage migration inhibitory factor binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070122"(isopeptidase activity)|go:"GO:1903894"(regulation of IRE1-mediated unfolded protein response)|go:"GO:1990182"(exosomal secretion)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR037518|interpro:IPR037740|interpro:IPR040961|mint:Q92905|rcsb pdb:4D10|rcsb pdb:4D18|rcsb pdb:4F7O|rcsb pdb:4WSN|rcsb pdb:5JOG|rcsb pdb:5JOH|rcsb pdb:5M5Q|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|reactome:R-HSA-5696394|reactome:R-HSA-6781823|reactome:R-HSA-8856825|reactome:R-HSA-8951664 ensembl:ENSG00000160959(gene)|ensembl:ENST00000292524(transcript)|ensembl:ENST00000529022(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0019900"(kinase binding)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR026292|interpro:IPR032675|refseq:NP_055480.1|refseq:NP_001258965.1|refseq:XP_005272415.1|refseq:XP_005272416.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:GMgH8dW3KWILX6Mr/+XrgAV3xY49606 rogid:/8PIIiNrB/FC2AzR1Spn1piB7kA9606 intact-crc:62C682BFC2A95F82|rigid:idT5K7H/rzoG1Ge3VgtYYQZGUuo false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q92905 uniprotkb:Q13098 intact:EBI-594661|uniprotkb:O15386|uniprotkb:Q6AW95|uniprotkb:Q86WQ4|uniprotkb:Q9BQ17|ensembl:ENSP00000350512 intact:EBI-725197|uniprotkb:Q8NA10|uniprotkb:Q9BWL1|ensembl:ENSP00000302873 psi-mi:csn5_human(display_long)|uniprotkb:Jun activation domain-binding protein 1(gene name synonym)|uniprotkb:COPS5(gene name)|psi-mi:COPS5(display_short)|uniprotkb:CSN5(gene name synonym)|uniprotkb:JAB1(gene name synonym) psi-mi:csn1_human(display_long)|uniprotkb:JAB1-containing signalosome subunit 1(gene name synonym)|uniprotkb:G protein pathway suppressor 1(gene name synonym)|uniprotkb:Protein MFH(gene name synonym)|uniprotkb:GPS1(gene name)|psi-mi:GPS1(display_short)|uniprotkb:COPS1(gene name synonym)|uniprotkb:CSN1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510150|imex:IM-12079-52 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006828.2|dip:DIP-34546N|ensembl:ENSG00000121022(gene)|ensembl:ENST00000357849(transcript)|go:"GO:0000338"(protein deneddylation)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006412"(translation)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019784"(NEDD8-specific protease activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0035718"(macrophage migration inhibitory factor binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070122"(isopeptidase activity)|go:"GO:1903894"(regulation of IRE1-mediated unfolded protein response)|go:"GO:1990182"(exosomal secretion)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR037518|interpro:IPR037740|interpro:IPR040961|mint:Q92905|rcsb pdb:4D10|rcsb pdb:4D18|rcsb pdb:4F7O|rcsb pdb:4WSN|rcsb pdb:5JOG|rcsb pdb:5JOH|rcsb pdb:5M5Q|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|reactome:R-HSA-5696394|reactome:R-HSA-6781823|reactome:R-HSA-8856825|reactome:R-HSA-8951664 refseq:NP_004118.3|refseq:NP_997657.1|ensembl:ENSG00000169727(gene)|ensembl:ENST00000306823(transcript)|go:"GO:0000188"(obsolete inactivation of MAPK activity)|go:"GO:0000338"(protein deneddylation)|go:"GO:0005095"(GTPase inhibitor activity)|go:"GO:0005654"(nucleoplasm)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR019585|interpro:IPR033008|interpro:IPR036390|mint:Q13098|rcsb pdb:4D10|rcsb pdb:4D18|rcsb pdb:4WSN|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|rcsb pdb:6R7N|go:"GO:0005829"(cytosol)|go:"GO:0007254"(JNK cascade)|go:"GO:0008180"(COP9 signalosome)|reactome:R-HSA-5696394|reactome:R-HSA-6781823|reactome:R-HSA-8856825|reactome:R-HSA-8951664|reactome:R-HSA-9013422|refseq:NP_001308021.1|refseq:XP_016880023.1|dip:DIP-42077N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:GMgH8dW3KWILX6Mr/+XrgAV3xY49606 rogid:OMWZ67qcgKTM0R/hy8L2oCa3cpo9606 intact-crc:62C682BFC2A95F82|rigid:idT5K7H/rzoG1Ge3VgtYYQZGUuo false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q92905 uniprotkb:Q9Y4B6 intact:EBI-594661|uniprotkb:O15386|uniprotkb:Q6AW95|uniprotkb:Q86WQ4|uniprotkb:Q9BQ17|ensembl:ENSP00000350512 intact:EBI-1996353|uniprotkb:Q2YD74|uniprotkb:Q8TBD9|uniprotkb:Q9HCA1|uniprotkb:Q9UG37|intact:EBI-2559078|intact:EBI-28988191|ensembl:ENSP00000393183|ensembl:ENSP00000506880 psi-mi:csn5_human(display_long)|uniprotkb:Jun activation domain-binding protein 1(gene name synonym)|uniprotkb:COPS5(gene name)|psi-mi:COPS5(display_short)|uniprotkb:CSN5(gene name synonym)|uniprotkb:JAB1(gene name synonym) psi-mi:dcaf1_human(display_long)|uniprotkb:DCAF1(gene name)|psi-mi:DCAF1(display_short)|uniprotkb:HIV-1 Vpr-binding protein(gene name synonym)|uniprotkb:KIAA0800(gene name synonym)|uniprotkb:RIP(gene name synonym)|uniprotkb:Serine/threonine-protein kinase VPRBP(gene name synonym)|uniprotkb:VPRBP(gene name synonym)|uniprotkb:Vpr-interacting protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510150|imex:IM-12079-52 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006828.2|dip:DIP-34546N|ensembl:ENSG00000121022(gene)|ensembl:ENST00000357849(transcript)|go:"GO:0000338"(protein deneddylation)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006412"(translation)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019784"(NEDD8-specific protease activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0035718"(macrophage migration inhibitory factor binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070122"(isopeptidase activity)|go:"GO:1903894"(regulation of IRE1-mediated unfolded protein response)|go:"GO:1990182"(exosomal secretion)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR037518|interpro:IPR037740|interpro:IPR040961|mint:Q92905|rcsb pdb:4D10|rcsb pdb:4D18|rcsb pdb:4F7O|rcsb pdb:4WSN|rcsb pdb:5JOG|rcsb pdb:5JOH|rcsb pdb:5M5Q|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|reactome:R-HSA-5696394|reactome:R-HSA-6781823|reactome:R-HSA-8856825|reactome:R-HSA-8951664 refseq:NP_001165375.1|refseq:NP_055518.1|refseq:XP_011532575.1|refseq:XP_011532576.1|refseq:XP_011532577.1|refseq:XP_011532578.1|refseq:XP_011532579.1|refseq:XP_016863035.1|refseq:XP_016863036.1|refseq:XP_016863037.1|refseq:XP_016863038.1|refseq:XP_016863039.1|ensembl:ENST00000335891|ensembl:ENSP00000338857|ensembl:ENSP00000393183|ensembl:ENST00000504652|ensembl:ENSP00000421724|ensembl:ENSP00000506880|ensembl:ENSG00000145041(gene)|ensembl:ENST00000423656(transcript)|ensembl:ENST00000684031(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001650"(fibrillar center)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0033151"("V(D)J recombination")|go:"GO:0035212"(cell competition in a multicellular organism)|go:"GO:0080008"(Cul4-RING E3 ubiquitin ligase complex)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1990244"("histone kinase activity (H2A-T120 specific)")|go:"GO:1990245"(histone H2A-T120 phosphorylation)|interpro:IPR006594(LisH dimerisation motif)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR033270|interpro:IPR036322|mint:Q9Y4B6|rcsb pdb:3WA0|rcsb pdb:4CC9|rcsb pdb:4P7I|rcsb pdb:4PXW|rcsb pdb:4Z8L|rcsb pdb:5AJA|rcsb pdb:5JK7|rcsb pdb:6N45|reactome:R-HSA-983168|refseq:XP_005276810.1|refseq:XP_005276812.1|dip:DIP-47048N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:GMgH8dW3KWILX6Mr/+XrgAV3xY49606 rogid:qs3qG0MM135EE/DjC1S/gCLRFhc9606 intact-crc:62C682BFC2A95F82|rigid:idT5K7H/rzoG1Ge3VgtYYQZGUuo false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q92905 uniprotkb:Q9P2N7 intact:EBI-594661|uniprotkb:O15386|uniprotkb:Q6AW95|uniprotkb:Q86WQ4|uniprotkb:Q9BQ17|ensembl:ENSP00000350512 intact:EBI-1996321|uniprotkb:D3DWH6|uniprotkb:Q6P2E3|uniprotkb:Q96QI7|uniprotkb:Q9UDN9|uniprotkb:B3KV78|uniprotkb:B3KWM7|uniprotkb:B7Z3S9|uniprotkb:B7Z5P2|uniprotkb:B7Z802|ensembl:ENSP00000262820 psi-mi:csn5_human(display_long)|uniprotkb:Jun activation domain-binding protein 1(gene name synonym)|uniprotkb:COPS5(gene name)|psi-mi:COPS5(display_short)|uniprotkb:CSN5(gene name synonym)|uniprotkb:JAB1(gene name synonym) psi-mi:klh13_human(display_long)|uniprotkb:KLHL13(gene name)|psi-mi:KLHL13(display_short)|uniprotkb:BKLHD2(gene name synonym)|uniprotkb:KIAA1309(gene name synonym)|uniprotkb:BTB and kelch domain-containing protein 2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510150|imex:IM-12079-52 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006828.2|dip:DIP-34546N|ensembl:ENSG00000121022(gene)|ensembl:ENST00000357849(transcript)|go:"GO:0000338"(protein deneddylation)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006412"(translation)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019784"(NEDD8-specific protease activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0035718"(macrophage migration inhibitory factor binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070122"(isopeptidase activity)|go:"GO:1903894"(regulation of IRE1-mediated unfolded protein response)|go:"GO:1990182"(exosomal secretion)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR037518|interpro:IPR037740|interpro:IPR040961|mint:Q92905|rcsb pdb:4D10|rcsb pdb:4D18|rcsb pdb:4F7O|rcsb pdb:4WSN|rcsb pdb:5JOG|rcsb pdb:5JOH|rcsb pdb:5M5Q|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|reactome:R-HSA-5696394|reactome:R-HSA-6781823|reactome:R-HSA-8856825|reactome:R-HSA-8951664 refseq:NP_001161771.1|refseq:NP_001161772.1|refseq:NP_001161773.1|refseq:NP_001161774.1|refseq:NP_001161775.1|refseq:NP_277030.2|refseq:XP_011529713.1|refseq:XP_016885439.1|interpro:IPR017096(Kelch-like protein, gigaxonin)|reactome:R-HSA-8951664|reactome:R-HSA-983168|ensembl:ENSG00000003096(gene)|ensembl:ENST00000262820(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0007049"(cell cycle)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030496"(midbody)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0051301"(cell division)|go:"GO:0097602"(cullin family protein binding)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR011705(BTB/Kelch-associated)|interpro:IPR015915(Kelch-type beta propeller) psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:GMgH8dW3KWILX6Mr/+XrgAV3xY49606 rogid:UP21yD93ihtJxCs8xNZ3FUB94tU9606 intact-crc:62C682BFC2A95F82|rigid:idT5K7H/rzoG1Ge3VgtYYQZGUuo false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q92905 uniprotkb:Q13617 intact:EBI-594661|uniprotkb:O15386|uniprotkb:Q6AW95|uniprotkb:Q86WQ4|uniprotkb:Q9BQ17|ensembl:ENSP00000350512 intact:EBI-456179|uniprotkb:O00200|uniprotkb:Q5T2B6|uniprotkb:Q9UNF9|uniprotkb:D3DRY6|uniprotkb:B3KT95|uniprotkb:B7Z6K8|uniprotkb:G3V1S2|ensembl:ENSP00000363881|ensembl:ENSP00000363883|ensembl:ENSP00000501215|ensembl:ENSP00000363880 psi-mi:csn5_human(display_long)|uniprotkb:Jun activation domain-binding protein 1(gene name synonym)|uniprotkb:COPS5(gene name)|psi-mi:COPS5(display_short)|uniprotkb:CSN5(gene name synonym)|uniprotkb:JAB1(gene name synonym) psi-mi:cul2_human(display_long)|uniprotkb:CUL2(gene name)|psi-mi:CUL2(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510150|imex:IM-12079-52 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006828.2|dip:DIP-34546N|ensembl:ENSG00000121022(gene)|ensembl:ENST00000357849(transcript)|go:"GO:0000338"(protein deneddylation)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006412"(translation)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019784"(NEDD8-specific protease activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0035718"(macrophage migration inhibitory factor binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070122"(isopeptidase activity)|go:"GO:1903894"(regulation of IRE1-mediated unfolded protein response)|go:"GO:1990182"(exosomal secretion)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR037518|interpro:IPR037740|interpro:IPR040961|mint:Q92905|rcsb pdb:4D10|rcsb pdb:4D18|rcsb pdb:4F7O|rcsb pdb:4WSN|rcsb pdb:5JOG|rcsb pdb:5JOH|rcsb pdb:5M5Q|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|reactome:R-HSA-5696394|reactome:R-HSA-6781823|reactome:R-HSA-8856825|reactome:R-HSA-8951664 refseq:NP_001185706.1|refseq:NP_001185707.1|refseq:NP_001185708.1|refseq:NP_003582.2|refseq:XP_011518049.1|dip:DIP-31612N|ensembl:ENST00000374748(transcript)|ensembl:ENST00000374749(transcript)|ensembl:ENST00000374751(transcript)|ensembl:ENST00000673636(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0030891"(VCB complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031462"(Cul2-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|interpro:IPR001373(Cullin, N-terminal region)|interpro:IPR016157(Cullin, conserved site)|interpro:IPR016158(Cullin homology)|interpro:IPR016159(Cullin repeat-like)|interpro:IPR019559|interpro:IPR036317|interpro:IPR036388|interpro:IPR036390|mint:Q13617|rcsb pdb:4WQO|rcsb pdb:5N4W|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|rcsb pdb:6R7N|reactome:R-HSA-1234176|reactome:R-HSA-8951664|ensembl:ENSG00000108094(gene)|reactome:R-HSA-983168|reactome:R-HSA-9010553 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:GMgH8dW3KWILX6Mr/+XrgAV3xY49606 rogid:ffttNV1NYH8UnmbHxf+ygcIG1wE9606 intact-crc:62C682BFC2A95F82|rigid:idT5K7H/rzoG1Ge3VgtYYQZGUuo false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q92905 uniprotkb:Q96L50 intact:EBI-594661|uniprotkb:O15386|uniprotkb:Q6AW95|uniprotkb:Q86WQ4|uniprotkb:Q9BQ17|ensembl:ENSP00000350512 intact:EBI-2510106|uniprotkb:B4DDE0|ensembl:ENSP00000298288|uniprotkb:A5D6X3|uniprotkb:Q52M24|uniprotkb:Q8N6H9|uniprotkb:Q86SZ1 psi-mi:csn5_human(display_long)|uniprotkb:Jun activation domain-binding protein 1(gene name synonym)|uniprotkb:COPS5(gene name)|psi-mi:COPS5(display_short)|uniprotkb:CSN5(gene name synonym)|uniprotkb:JAB1(gene name synonym) psi-mi:llr1_human(display_long)|uniprotkb:LRR1(gene name)|psi-mi:LRR1(display_short)|uniprotkb:PPIL5(gene name synonym)|uniprotkb:LRR-repeat protein 1(gene name synonym)|uniprotkb:4-1BB-mediated-signaling molecule(gene name synonym)|uniprotkb:4-1BBlrr(gene name synonym)|uniprotkb:Peptidylprolyl isomerase-like 5(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510150|imex:IM-12079-52 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006828.2|dip:DIP-34546N|ensembl:ENSG00000121022(gene)|ensembl:ENST00000357849(transcript)|go:"GO:0000338"(protein deneddylation)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006412"(translation)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019784"(NEDD8-specific protease activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0035718"(macrophage migration inhibitory factor binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070122"(isopeptidase activity)|go:"GO:1903894"(regulation of IRE1-mediated unfolded protein response)|go:"GO:1990182"(exosomal secretion)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR037518|interpro:IPR037740|interpro:IPR040961|mint:Q92905|rcsb pdb:4D10|rcsb pdb:4D18|rcsb pdb:4F7O|rcsb pdb:4WSN|rcsb pdb:5JOG|rcsb pdb:5JOH|rcsb pdb:5M5Q|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|reactome:R-HSA-5696394|reactome:R-HSA-6781823|reactome:R-HSA-8856825|reactome:R-HSA-8951664 ensembl:ENSG00000165501(gene)|ensembl:ENST00000298288(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0016567"(protein ubiquitination)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR025875|interpro:IPR032675|reactome:R-HSA-8951664|reactome:R-HSA-983168|refseq:NP_689542.2|refseq:NP_982292.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:GMgH8dW3KWILX6Mr/+XrgAV3xY49606 rogid:7znZddT/rr1wCuorp9l6jxzsujE9606 intact-crc:62C682BFC2A95F82|rigid:idT5K7H/rzoG1Ge3VgtYYQZGUuo false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q92905 uniprotkb:Q53GT1 intact:EBI-594661|uniprotkb:O15386|uniprotkb:Q6AW95|uniprotkb:Q86WQ4|uniprotkb:Q9BQ17|ensembl:ENSP00000350512 intact:EBI-1996072|uniprotkb:D3DX30|uniprotkb:Q96B68|uniprotkb:Q96KC6|uniprotkb:A8MTV3|uniprotkb:A8K3Q4|ensembl:ENSP00000331682|uniprotkb:B7Z2G1 psi-mi:csn5_human(display_long)|uniprotkb:Jun activation domain-binding protein 1(gene name synonym)|uniprotkb:COPS5(gene name)|psi-mi:COPS5(display_short)|uniprotkb:CSN5(gene name synonym)|uniprotkb:JAB1(gene name synonym) psi-mi:klh22_human(display_long)|uniprotkb:KLHL22(gene name)|psi-mi:KLHL22(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510150|imex:IM-12079-52 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006828.2|dip:DIP-34546N|ensembl:ENSG00000121022(gene)|ensembl:ENST00000357849(transcript)|go:"GO:0000338"(protein deneddylation)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006412"(translation)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019784"(NEDD8-specific protease activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0035718"(macrophage migration inhibitory factor binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070122"(isopeptidase activity)|go:"GO:1903894"(regulation of IRE1-mediated unfolded protein response)|go:"GO:1990182"(exosomal secretion)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR037518|interpro:IPR037740|interpro:IPR040961|mint:Q92905|rcsb pdb:4D10|rcsb pdb:4D18|rcsb pdb:4F7O|rcsb pdb:4WSN|rcsb pdb:5JOG|rcsb pdb:5JOH|rcsb pdb:5M5Q|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|reactome:R-HSA-5696394|reactome:R-HSA-6781823|reactome:R-HSA-8856825|reactome:R-HSA-8951664 refseq:NP_116164.2|refseq:XP_016884510.1|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005813"(centrosome)|go:"GO:0005827"(polar microtubule)|go:"GO:0005829"(cytosol)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045171"(intercellular bridge)|go:"GO:0051301"(cell division)|go:"GO:0071233"(cellular response to leucine)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0072686"(mitotic spindle)|go:"GO:1904263"(positive regulation of TORC1 signaling)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR011705(BTB/Kelch-associated)|interpro:IPR015915(Kelch-type beta propeller)|interpro:IPR017096(Kelch-like protein, gigaxonin)|interpro:IPR030575|mint:Q53GT1|reactome:R-HSA-8951664|reactome:R-HSA-983168|ensembl:ENSG00000099910(gene)|ensembl:ENST00000328879(transcript) psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:GMgH8dW3KWILX6Mr/+XrgAV3xY49606 rogid:EC3vXSWYpde+ZCa6lm86DF+sfM89606 intact-crc:62C682BFC2A95F82|rigid:idT5K7H/rzoG1Ge3VgtYYQZGUuo false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q92905 uniprotkb:Q9UNS2 intact:EBI-594661|uniprotkb:O15386|uniprotkb:Q6AW95|uniprotkb:Q86WQ4|uniprotkb:Q9BQ17|ensembl:ENSP00000350512 intact:EBI-350590|uniprotkb:O43191|uniprotkb:Q7LDR6|uniprotkb:B2R683|ensembl:ENSP00000268717|uniprotkb:B4DY81 psi-mi:csn5_human(display_long)|uniprotkb:Jun activation domain-binding protein 1(gene name synonym)|uniprotkb:COPS5(gene name)|psi-mi:COPS5(display_short)|uniprotkb:CSN5(gene name synonym)|uniprotkb:JAB1(gene name synonym) psi-mi:csn3_human(display_long)|uniprotkb:COPS3(gene name)|psi-mi:COPS3(display_short)|uniprotkb:CSN3(gene name synonym)|uniprotkb:JAB1-containing signalosome subunit 3(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510150|imex:IM-12079-52 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006828.2|dip:DIP-34546N|ensembl:ENSG00000121022(gene)|ensembl:ENST00000357849(transcript)|go:"GO:0000338"(protein deneddylation)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006412"(translation)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019784"(NEDD8-specific protease activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0035718"(macrophage migration inhibitory factor binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070122"(isopeptidase activity)|go:"GO:1903894"(regulation of IRE1-mediated unfolded protein response)|go:"GO:1990182"(exosomal secretion)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR037518|interpro:IPR037740|interpro:IPR040961|mint:Q92905|rcsb pdb:4D10|rcsb pdb:4D18|rcsb pdb:4F7O|rcsb pdb:4WSN|rcsb pdb:5JOG|rcsb pdb:5JOH|rcsb pdb:5M5Q|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|reactome:R-HSA-5696394|reactome:R-HSA-6781823|reactome:R-HSA-8856825|reactome:R-HSA-8951664 refseq:NP_001186054.1|refseq:NP_003644.2|ensembl:ENSG00000141030(gene)|ensembl:ENST00000268717(transcript)|go:"GO:0000338"(protein deneddylation)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0009416"(response to light stimulus)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR036390|interpro:IPR037753|mint:Q9UNS2|rcsb pdb:4D10|rcsb pdb:4D18|rcsb pdb:4WSN|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|rcsb pdb:6R7N|reactome:R-HSA-5696394|reactome:R-HSA-6781823|reactome:R-HSA-8856825|reactome:R-HSA-8951664|rcsb pdb:6R6H|refseq:NP_001303283.1|refseq:NP_001303284.1|refseq:NP_001303285.1|refseq:NP_001303286.1|refseq:NP_001303287.1|refseq:XP_005256894.1|dip:DIP-32478N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:GMgH8dW3KWILX6Mr/+XrgAV3xY49606 rogid:z6E/tPEo/ksVxD5Yyfo89t+ww989606 intact-crc:62C682BFC2A95F82|rigid:idT5K7H/rzoG1Ge3VgtYYQZGUuo false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q92905 uniprotkb:Q13216 intact:EBI-594661|uniprotkb:O15386|uniprotkb:Q6AW95|uniprotkb:Q86WQ4|uniprotkb:Q9BQ17|ensembl:ENSP00000350512 intact:EBI-295260|uniprotkb:Q6FHX5|uniprotkb:Q96GB9|uniprotkb:B2RB64|intact:EBI-28983947|ensembl:ENSP00000501614 psi-mi:csn5_human(display_long)|uniprotkb:Jun activation domain-binding protein 1(gene name synonym)|uniprotkb:COPS5(gene name)|psi-mi:COPS5(display_short)|uniprotkb:CSN5(gene name synonym)|uniprotkb:JAB1(gene name synonym) psi-mi:ercc8_human(display_long)|uniprotkb:ERCC8(gene name)|psi-mi:ERCC8(display_short)|uniprotkb:CSA(gene name synonym)|uniprotkb:CKN1(gene name synonym)|uniprotkb:Cockayne syndrome WD repeat protein CSA(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510150|imex:IM-12079-52 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006828.2|dip:DIP-34546N|ensembl:ENSG00000121022(gene)|ensembl:ENST00000357849(transcript)|go:"GO:0000338"(protein deneddylation)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006412"(translation)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019784"(NEDD8-specific protease activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0035718"(macrophage migration inhibitory factor binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070122"(isopeptidase activity)|go:"GO:1903894"(regulation of IRE1-mediated unfolded protein response)|go:"GO:1990182"(exosomal secretion)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR037518|interpro:IPR037740|interpro:IPR040961|mint:Q92905|rcsb pdb:4D10|rcsb pdb:4D18|rcsb pdb:4F7O|rcsb pdb:4WSN|rcsb pdb:5JOG|rcsb pdb:5JOH|rcsb pdb:5M5Q|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|reactome:R-HSA-5696394|reactome:R-HSA-6781823|reactome:R-HSA-8856825|reactome:R-HSA-8951664 refseq:NP_001007235.1|refseq:NP_000073.1|ensembl:ENST00000647486|ensembl:ENSP00000494466|ensembl:ENST00000675229|ensembl:ENSP00000502154|ensembl:ENSP00000501614|dip:DIP-291N|ensembl:ENSG00000049167(gene)|ensembl:ENST00000676185(transcript)|go:"GO:0000012"(single strand break repair)|go:"GO:0000109"(nucleotide-excision repair complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006283"(transcription-coupled nucleotide-excision repair)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0009411"(response to UV)|go:"GO:0016363"(nuclear matrix)|go:"GO:0031464"(Cul4A-RING E3 ubiquitin ligase complex)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0080008"(Cul4-RING E3 ubiquitin ligase complex)|go:"GO:0097680"(double-strand break repair via classical nonhomologous end joining)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|interpro:IPR042238|rcsb pdb:4A11|rcsb pdb:6FCV|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-8951664 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:GMgH8dW3KWILX6Mr/+XrgAV3xY49606 rogid:rAvPc8OiKusCMRi//0rJWsMu+dg9606 intact-crc:62C682BFC2A95F82|rigid:idT5K7H/rzoG1Ge3VgtYYQZGUuo false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q92905 uniprotkb:O94889 intact:EBI-594661|uniprotkb:O15386|uniprotkb:Q6AW95|uniprotkb:Q86WQ4|uniprotkb:Q9BQ17|ensembl:ENSP00000350512 intact:EBI-2510096|uniprotkb:Q7Z3E8|uniprotkb:Q8N125|uniprotkb:A8K612|ensembl:ENSP00000232766 psi-mi:csn5_human(display_long)|uniprotkb:Jun activation domain-binding protein 1(gene name synonym)|uniprotkb:COPS5(gene name)|psi-mi:COPS5(display_short)|uniprotkb:CSN5(gene name synonym)|uniprotkb:JAB1(gene name synonym) psi-mi:klh18_human(display_long)|uniprotkb:KLHL18(gene name)|psi-mi:KLHL18(display_short)|uniprotkb:KIAA0795(gene name synonym)|uniprotkb:OK/SW-cl.74(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510150|imex:IM-12079-52 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006828.2|dip:DIP-34546N|ensembl:ENSG00000121022(gene)|ensembl:ENST00000357849(transcript)|go:"GO:0000338"(protein deneddylation)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006412"(translation)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019784"(NEDD8-specific protease activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0035718"(macrophage migration inhibitory factor binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070122"(isopeptidase activity)|go:"GO:1903894"(regulation of IRE1-mediated unfolded protein response)|go:"GO:1990182"(exosomal secretion)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR037518|interpro:IPR037740|interpro:IPR040961|mint:Q92905|rcsb pdb:4D10|rcsb pdb:4D18|rcsb pdb:4F7O|rcsb pdb:4WSN|rcsb pdb:5JOG|rcsb pdb:5JOH|rcsb pdb:5M5Q|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|reactome:R-HSA-5696394|reactome:R-HSA-6781823|reactome:R-HSA-8856825|reactome:R-HSA-8951664 refseq:NP_079286.2|ensembl:ENSG00000114648(gene)|ensembl:ENST00000232766(transcript)|go:"GO:0007049"(cell cycle)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0051301"(cell division)|go:"GO:1901992"(positive regulation of mitotic cell cycle phase transition)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR011705(BTB/Kelch-associated)|interpro:IPR015915(Kelch-type beta propeller)|interpro:IPR017096(Kelch-like protein, gigaxonin)|interpro:IPR030603 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:GMgH8dW3KWILX6Mr/+XrgAV3xY49606 rogid:mSO8Uw0maleiD2Ri6RuERO1OpiQ9606 intact-crc:62C682BFC2A95F82|rigid:idT5K7H/rzoG1Ge3VgtYYQZGUuo false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q92905 uniprotkb:B4DN30 intact:EBI-594661|uniprotkb:O15386|uniprotkb:Q6AW95|uniprotkb:Q86WQ4|uniprotkb:Q9BQ17|ensembl:ENSP00000350512 intact:EBI-2510114 psi-mi:csn5_human(display_long)|uniprotkb:Jun activation domain-binding protein 1(gene name synonym)|uniprotkb:COPS5(gene name)|psi-mi:COPS5(display_short)|uniprotkb:CSN5(gene name synonym)|uniprotkb:JAB1(gene name synonym) psi-mi:b4dn30_human(display_long) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510150|imex:IM-12079-52 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006828.2|dip:DIP-34546N|ensembl:ENSG00000121022(gene)|ensembl:ENST00000357849(transcript)|go:"GO:0000338"(protein deneddylation)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006412"(translation)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019784"(NEDD8-specific protease activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0035718"(macrophage migration inhibitory factor binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070122"(isopeptidase activity)|go:"GO:1903894"(regulation of IRE1-mediated unfolded protein response)|go:"GO:1990182"(exosomal secretion)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR037518|interpro:IPR037740|interpro:IPR040961|mint:Q92905|rcsb pdb:4D10|rcsb pdb:4D18|rcsb pdb:4F7O|rcsb pdb:4WSN|rcsb pdb:5JOG|rcsb pdb:5JOH|rcsb pdb:5M5Q|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|reactome:R-HSA-5696394|reactome:R-HSA-6781823|reactome:R-HSA-8856825|reactome:R-HSA-8951664 interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR001680(WD40 repeat)|refseq:NP_001156981.1|interpro:IPR036322 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:GMgH8dW3KWILX6Mr/+XrgAV3xY49606 rogid:Mk9d67PQ07hQYLpZ+jTq4hfKRWk9606 intact-crc:62C682BFC2A95F82|rigid:idT5K7H/rzoG1Ge3VgtYYQZGUuo false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q7L5N1 uniprotkb:Q9C0D3 intact:EBI-486838|uniprotkb:O15387|uniprotkb:A4D2A3|ensembl:ENSP00000304102 intact:EBI-1811414|uniprotkb:Q8N2X3|uniprotkb:Q9H8L8|ensembl:ENSP00000294353 psi-mi:csn6_human(display_long)|uniprotkb:COPS6(gene name)|psi-mi:COPS6(display_short)|uniprotkb:CSN6(gene name synonym)|uniprotkb:HVIP(gene name synonym)|uniprotkb:JAB1-containing signalosome subunit 6(gene name synonym)|uniprotkb:Vpr-interacting protein(gene name synonym)|uniprotkb:MOV34 homolog(gene name synonym) psi-mi:zy11b_human(display_long)|uniprotkb:ZYG11B(gene name)|psi-mi:ZYG11B(display_short)|uniprotkb:KIAA1730(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510262|imex:IM-12079-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006824.2|ensembl:ENSG00000168090(gene)|ensembl:ENST00000303904(transcript)|go:"GO:0000338"(protein deneddylation)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070122"(isopeptidase activity)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR033859|interpro:IPR024969|interpro:IPR037518|mint:Q7L5N1|rcsb pdb:4D10|rcsb pdb:4D18|rcsb pdb:4QFT|rcsb pdb:4R14|rcsb pdb:4WSN|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|reactome:R-HSA-5696394|reactome:R-HSA-6781823|reactome:R-HSA-8856825|reactome:R-HSA-8951664|dip:DIP-32655N refseq:NP_078922.1|ensembl:ENSG00000162378(gene)|ensembl:ENST00000294353(transcript)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0031462"(Cul2-RING ubiquitin ligase complex)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR032675|interpro:IPR040367|mint:Q9C0D3 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2020/10/21 rogid:hyuYyAujJCJtbfS2tJ+UgH7jWP89606 rogid:PL/P806AUcYTlvB6/2VS/UxLUYg9606 intact-crc:B58AF288F9C81A77|rigid:/fWQJTQK1fD0fpKu4c/6K/d+bMo false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q7L5N1 uniprotkb:Q6TFL4 intact:EBI-486838|uniprotkb:O15387|uniprotkb:A4D2A3|ensembl:ENSP00000304102 intact:EBI-2510117|intact:EBI-28976209|ensembl:ENSP00000242810|ensembl:ENSP00000395012|uniprotkb:A5PLN8|uniprotkb:Q9H620|uniprotkb:Q9NXT9 psi-mi:csn6_human(display_long)|uniprotkb:COPS6(gene name)|psi-mi:COPS6(display_short)|uniprotkb:CSN6(gene name synonym)|uniprotkb:HVIP(gene name synonym)|uniprotkb:JAB1-containing signalosome subunit 6(gene name synonym)|uniprotkb:Vpr-interacting protein(gene name synonym)|uniprotkb:MOV34 homolog(gene name synonym) psi-mi:klh24_human(display_long)|uniprotkb:KLHL24(gene name)|psi-mi:KLHL24(display_short)|uniprotkb:DRE1(gene name synonym)|uniprotkb:Kainate receptor-interacting protein for GluR6(gene name synonym)|uniprotkb:Protein DRE1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510262|imex:IM-12079-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006824.2|ensembl:ENSG00000168090(gene)|ensembl:ENST00000303904(transcript)|go:"GO:0000338"(protein deneddylation)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070122"(isopeptidase activity)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR033859|interpro:IPR024969|interpro:IPR037518|mint:Q7L5N1|rcsb pdb:4D10|rcsb pdb:4D18|rcsb pdb:4QFT|rcsb pdb:4R14|rcsb pdb:4WSN|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|reactome:R-HSA-5696394|reactome:R-HSA-6781823|reactome:R-HSA-8856825|reactome:R-HSA-8951664|dip:DIP-32655N ensembl:ENSG00000114796(gene)|ensembl:ENST00000242810(transcript)|ensembl:ENST00000454652(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005912"(adherens junction)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030057"(desmosome)|go:"GO:0030424"(axon)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0043204"(perikaryon)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:2000312"(regulation of kainate selective glutamate receptor activity)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR011705(BTB/Kelch-associated)|interpro:IPR015915(Kelch-type beta propeller)|interpro:IPR017096(Kelch-like protein, gigaxonin)|interpro:IPR030596|ensembl:ENSP00000242810|ensembl:ENSP00000395012|ensembl:ENST00000476808|ensembl:ENSP00000419010|refseq:XP_011511240.1|refseq:NP_060114.2|refseq:XP_005247609.1|refseq:XP_005247610.1|refseq:XP_005247611.1|refseq:XP_005247612.1|refseq:XP_005247613.1|refseq:XP_016862148.1|refseq:XP_016862149.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2020/10/21 rogid:hyuYyAujJCJtbfS2tJ+UgH7jWP89606 rogid:bzDmcJFRhPoULz94KRhkDrQg+Bk9606 intact-crc:B58AF288F9C81A77|rigid:/fWQJTQK1fD0fpKu4c/6K/d+bMo false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q7L5N1 uniprotkb:Q96SW2 intact:EBI-486838|uniprotkb:O15387|uniprotkb:A4D2A3|ensembl:ENSP00000304102 intact:EBI-2510250|ensembl:ENSP00000231948|uniprotkb:B2R6H4|uniprotkb:C9IZA9|uniprotkb:C9JAH6|uniprotkb:Q6NVZ0|uniprotkb:Q6AI62|uniprotkb:Q9UHW4 psi-mi:csn6_human(display_long)|uniprotkb:COPS6(gene name)|psi-mi:COPS6(display_short)|uniprotkb:CSN6(gene name synonym)|uniprotkb:HVIP(gene name synonym)|uniprotkb:JAB1-containing signalosome subunit 6(gene name synonym)|uniprotkb:Vpr-interacting protein(gene name synonym)|uniprotkb:MOV34 homolog(gene name synonym) psi-mi:crbn_human(display_long)|uniprotkb:CRBN(gene name)|psi-mi:CRBN(display_short)|uniprotkb:AD-006(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510262|imex:IM-12079-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006824.2|ensembl:ENSG00000168090(gene)|ensembl:ENST00000303904(transcript)|go:"GO:0000338"(protein deneddylation)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070122"(isopeptidase activity)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR033859|interpro:IPR024969|interpro:IPR037518|mint:Q7L5N1|rcsb pdb:4D10|rcsb pdb:4D18|rcsb pdb:4QFT|rcsb pdb:4R14|rcsb pdb:4WSN|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|reactome:R-HSA-5696394|reactome:R-HSA-6781823|reactome:R-HSA-8856825|reactome:R-HSA-8951664|dip:DIP-32655N go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031464"(Cul4A-RING E3 ubiquitin ligase complex)|go:"GO:0035641"(locomotory exploration behavior)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:1902607"(negative regulation of large conductance calcium-activated potassium channel activity)|interpro:IPR003111(Peptidase S16, lon N-terminal)|interpro:IPR004910(Yippee-like protein)|interpro:IPR034750|mint:Q96SW2|rcsb pdb:4M91|rcsb pdb:4TZ4|rcsb pdb:5FQD|rcsb pdb:5HXB|rcsb pdb:5V3O|rcsb pdb:6BN7|rcsb pdb:6BN8|rcsb pdb:6BN9|rcsb pdb:6BNB|rcsb pdb:6BOY|interpro:IPR015947(PUA-like)|rcsb pdb:6H0F|rcsb pdb:6H0G|rcsb pdb:6UML|rcsb pdb:6XK9|rcsb pdb:7BQU|rcsb pdb:7BQV|rcsb pdb:7LPS|reactome:R-HSA-9679191|ensembl:ENSG00000113851(gene)|ensembl:ENST00000231948(transcript)|refseq:NP_057386.2|refseq:NP_001166953.1|dip:DIP-53521N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2020/10/21 rogid:hyuYyAujJCJtbfS2tJ+UgH7jWP89606 rogid:R1sZch07ti/kUKYBByte0xAoCMo9606 intact-crc:B58AF288F9C81A77|rigid:/fWQJTQK1fD0fpKu4c/6K/d+bMo false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q7L5N1 uniprotkb:Q9UNS2 intact:EBI-486838|uniprotkb:O15387|uniprotkb:A4D2A3|ensembl:ENSP00000304102 intact:EBI-350590|uniprotkb:O43191|uniprotkb:Q7LDR6|uniprotkb:B2R683|ensembl:ENSP00000268717|uniprotkb:B4DY81 psi-mi:csn6_human(display_long)|uniprotkb:COPS6(gene name)|psi-mi:COPS6(display_short)|uniprotkb:CSN6(gene name synonym)|uniprotkb:HVIP(gene name synonym)|uniprotkb:JAB1-containing signalosome subunit 6(gene name synonym)|uniprotkb:Vpr-interacting protein(gene name synonym)|uniprotkb:MOV34 homolog(gene name synonym) psi-mi:csn3_human(display_long)|uniprotkb:COPS3(gene name)|psi-mi:COPS3(display_short)|uniprotkb:CSN3(gene name synonym)|uniprotkb:JAB1-containing signalosome subunit 3(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510262|imex:IM-12079-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006824.2|ensembl:ENSG00000168090(gene)|ensembl:ENST00000303904(transcript)|go:"GO:0000338"(protein deneddylation)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070122"(isopeptidase activity)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR033859|interpro:IPR024969|interpro:IPR037518|mint:Q7L5N1|rcsb pdb:4D10|rcsb pdb:4D18|rcsb pdb:4QFT|rcsb pdb:4R14|rcsb pdb:4WSN|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|reactome:R-HSA-5696394|reactome:R-HSA-6781823|reactome:R-HSA-8856825|reactome:R-HSA-8951664|dip:DIP-32655N refseq:NP_001186054.1|refseq:NP_003644.2|ensembl:ENSG00000141030(gene)|ensembl:ENST00000268717(transcript)|go:"GO:0000338"(protein deneddylation)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0009416"(response to light stimulus)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR036390|interpro:IPR037753|mint:Q9UNS2|rcsb pdb:4D10|rcsb pdb:4D18|rcsb pdb:4WSN|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|rcsb pdb:6R7N|reactome:R-HSA-5696394|reactome:R-HSA-6781823|reactome:R-HSA-8856825|reactome:R-HSA-8951664|rcsb pdb:6R6H|refseq:NP_001303283.1|refseq:NP_001303284.1|refseq:NP_001303285.1|refseq:NP_001303286.1|refseq:NP_001303287.1|refseq:XP_005256894.1|dip:DIP-32478N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2020/10/21 rogid:hyuYyAujJCJtbfS2tJ+UgH7jWP89606 rogid:z6E/tPEo/ksVxD5Yyfo89t+ww989606 intact-crc:B58AF288F9C81A77|rigid:/fWQJTQK1fD0fpKu4c/6K/d+bMo false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q7L5N1 uniprotkb:Q96Q07 intact:EBI-486838|uniprotkb:O15387|uniprotkb:A4D2A3|ensembl:ENSP00000304102 intact:EBI-2510245|ensembl:ENSP00000418751|ensembl:ENSP00000497066|uniprotkb:Q494V9|uniprotkb:Q96M00|uniprotkb:Q494W1 psi-mi:csn6_human(display_long)|uniprotkb:COPS6(gene name)|psi-mi:COPS6(display_short)|uniprotkb:CSN6(gene name synonym)|uniprotkb:HVIP(gene name synonym)|uniprotkb:JAB1-containing signalosome subunit 6(gene name synonym)|uniprotkb:Vpr-interacting protein(gene name synonym)|uniprotkb:MOV34 homolog(gene name synonym) psi-mi:btbd9_human(display_long)|uniprotkb:BTBD9(gene name)|psi-mi:BTBD9(display_short)|uniprotkb:KIAA1880(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510262|imex:IM-12079-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006824.2|ensembl:ENSG00000168090(gene)|ensembl:ENST00000303904(transcript)|go:"GO:0000338"(protein deneddylation)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070122"(isopeptidase activity)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR033859|interpro:IPR024969|interpro:IPR037518|mint:Q7L5N1|rcsb pdb:4D10|rcsb pdb:4D18|rcsb pdb:4QFT|rcsb pdb:4R14|rcsb pdb:4WSN|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|reactome:R-HSA-5696394|reactome:R-HSA-6781823|reactome:R-HSA-8856825|reactome:R-HSA-8951664|dip:DIP-32655N ensembl:ENSG00000183826(gene)|ensembl:ENST00000481247(transcript)|ensembl:ENST00000649492(transcript)|go:"GO:0007616"(long-term memory)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0042428"(serotonin metabolic process)|go:"GO:0042748"(circadian sleep/wake cycle, non-REM sleep)|go:"GO:0048512"(circadian behavior)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050951"(sensory perception of temperature stimulus)|go:"GO:0060586"(multicellular organismal iron ion homeostasis)|go:"GO:1900242"(regulation of synaptic vesicle endocytosis)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR000421(Coagulation factor 5/8 type, C-terminal)|interpro:IPR008979(Galactose-binding like)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR011705(BTB/Kelch-associated)|interpro:IPR034091|refseq:XP_011512581.1|refseq:NP_001092742.1|refseq:NP_001165889.1|refseq:NP_443125.1|refseq:NP_689946.2 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2020/10/21 rogid:hyuYyAujJCJtbfS2tJ+UgH7jWP89606 rogid:cjdtAwudivBKATkCJ5R/vYLhx4g9606 intact-crc:B58AF288F9C81A77|rigid:/fWQJTQK1fD0fpKu4c/6K/d+bMo false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q7L5N1 uniprotkb:Q15048 intact:EBI-486838|uniprotkb:O15387|uniprotkb:A4D2A3|ensembl:ENSP00000304102 intact:EBI-2510124|ensembl:ENSP00000292524|ensembl:ENSP00000434768|uniprotkb:A8K0A8|uniprotkb:D3DWM8 psi-mi:csn6_human(display_long)|uniprotkb:COPS6(gene name)|psi-mi:COPS6(display_short)|uniprotkb:CSN6(gene name synonym)|uniprotkb:HVIP(gene name synonym)|uniprotkb:JAB1-containing signalosome subunit 6(gene name synonym)|uniprotkb:Vpr-interacting protein(gene name synonym)|uniprotkb:MOV34 homolog(gene name synonym) psi-mi:lrc14_human(display_long)|uniprotkb:LRRC14(gene name)|psi-mi:LRRC14(display_short)|uniprotkb:KIAA0014(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510262|imex:IM-12079-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006824.2|ensembl:ENSG00000168090(gene)|ensembl:ENST00000303904(transcript)|go:"GO:0000338"(protein deneddylation)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070122"(isopeptidase activity)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR033859|interpro:IPR024969|interpro:IPR037518|mint:Q7L5N1|rcsb pdb:4D10|rcsb pdb:4D18|rcsb pdb:4QFT|rcsb pdb:4R14|rcsb pdb:4WSN|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|reactome:R-HSA-5696394|reactome:R-HSA-6781823|reactome:R-HSA-8856825|reactome:R-HSA-8951664|dip:DIP-32655N ensembl:ENSG00000160959(gene)|ensembl:ENST00000292524(transcript)|ensembl:ENST00000529022(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0019900"(kinase binding)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR026292|interpro:IPR032675|refseq:NP_055480.1|refseq:NP_001258965.1|refseq:XP_005272415.1|refseq:XP_005272416.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2020/10/21 rogid:hyuYyAujJCJtbfS2tJ+UgH7jWP89606 rogid:/8PIIiNrB/FC2AzR1Spn1piB7kA9606 intact-crc:B58AF288F9C81A77|rigid:/fWQJTQK1fD0fpKu4c/6K/d+bMo false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q7L5N1 uniprotkb:Q96EF6 intact:EBI-486838|uniprotkb:O15387|uniprotkb:A4D2A3|ensembl:ENSP00000304102 intact:EBI-2510157|ensembl:ENSP00000292852|ensembl:ENSP00000470361|ensembl:ENSP00000488997|ensembl:ENSP00000489327|uniprotkb:Q96LQ4 psi-mi:csn6_human(display_long)|uniprotkb:COPS6(gene name)|psi-mi:COPS6(display_short)|uniprotkb:CSN6(gene name synonym)|uniprotkb:HVIP(gene name synonym)|uniprotkb:JAB1-containing signalosome subunit 6(gene name synonym)|uniprotkb:Vpr-interacting protein(gene name synonym)|uniprotkb:MOV34 homolog(gene name synonym) psi-mi:fbx17_human(display_long)|uniprotkb:FBXO17(gene name)|psi-mi:FBXO17(display_short)|uniprotkb:FBG4(gene name synonym)|uniprotkb:FBX17(gene name synonym)|uniprotkb:FBX26(gene name synonym)|uniprotkb:FBXO26(gene name synonym)|uniprotkb:F-box only protein 26(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510262|imex:IM-12079-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006824.2|ensembl:ENSG00000168090(gene)|ensembl:ENST00000303904(transcript)|go:"GO:0000338"(protein deneddylation)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070122"(isopeptidase activity)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR033859|interpro:IPR024969|interpro:IPR037518|mint:Q7L5N1|rcsb pdb:4D10|rcsb pdb:4D18|rcsb pdb:4QFT|rcsb pdb:4R14|rcsb pdb:4WSN|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|reactome:R-HSA-5696394|reactome:R-HSA-6781823|reactome:R-HSA-8856825|reactome:R-HSA-8951664|dip:DIP-32655N ensembl:ENSG00000269190(gene)|ensembl:ENSG00000282954(gene)|ensembl:ENST00000634982(transcript)|ensembl:ENST00000635115(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006516"(glycoprotein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR007397(F-box associated region)|interpro:IPR008979(Galactose-binding like)|ensembl:ENST00000292852(transcript)|ensembl:ENST00000595329(transcript)|interpro:IPR036047|interpro:IPR039752|mint:Q96EF6|reactome:R-HSA-8951664|reactome:R-HSA-983168|refseq:NP_079183.4|refseq:NP_680474.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2020/10/21 rogid:hyuYyAujJCJtbfS2tJ+UgH7jWP89606 rogid:yc7kMZQhjtDMtTD97TFdPZnGPPk9606 intact-crc:B58AF288F9C81A77|rigid:/fWQJTQK1fD0fpKu4c/6K/d+bMo false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q7L5N1 uniprotkb:Q13618 intact:EBI-486838|uniprotkb:O15387|uniprotkb:A4D2A3|ensembl:ENSP00000304102 intact:EBI-456129|uniprotkb:O75415|uniprotkb:Q569L3|uniprotkb:Q9UBI8|uniprotkb:B8ZZC3|uniprotkb:Q9UET7|uniprotkb:A8K536|ensembl:ENSP00000264414 psi-mi:csn6_human(display_long)|uniprotkb:COPS6(gene name)|psi-mi:COPS6(display_short)|uniprotkb:CSN6(gene name synonym)|uniprotkb:HVIP(gene name synonym)|uniprotkb:JAB1-containing signalosome subunit 6(gene name synonym)|uniprotkb:Vpr-interacting protein(gene name synonym)|uniprotkb:MOV34 homolog(gene name synonym) psi-mi:cul3_human(display_long)|uniprotkb:CUL3(gene name)|psi-mi:CUL3(display_short)|uniprotkb:KIAA0617(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510262|imex:IM-12079-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006824.2|ensembl:ENSG00000168090(gene)|ensembl:ENST00000303904(transcript)|go:"GO:0000338"(protein deneddylation)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070122"(isopeptidase activity)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR033859|interpro:IPR024969|interpro:IPR037518|mint:Q7L5N1|rcsb pdb:4D10|rcsb pdb:4D18|rcsb pdb:4QFT|rcsb pdb:4R14|rcsb pdb:4WSN|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|reactome:R-HSA-5696394|reactome:R-HSA-6781823|reactome:R-HSA-8856825|reactome:R-HSA-8951664|dip:DIP-32655N refseq:NP_003581.1|refseq:NP_001244126.1|refseq:NP_001244127.1|dip:DIP-31611N|ensembl:ENSG00000036257(gene)|ensembl:ENST00000264414(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000922"(spindle pole)|go:"GO:0001831"(trophectodermal cellular morphogenesis)|go:"GO:0005112"(Notch binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005827"(polar microtubule)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007369"(gastrulation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016477"(cell migration)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0017145"(stem cell division)|go:"GO:0030030"(cell projection organization)|go:"GO:0030332"(cyclin binding)|go:"GO:0031145"(anaphase-promoting complex-dependent catabolic process)|go:"GO:0031208"(POZ domain binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0036126"(sperm flagellum)|go:"GO:0040016"(embryonic cleavage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044346"(fibroblast apoptotic process)|go:"GO:0045842"(positive regulation of mitotic metaphase/anaphase transition)|go:"GO:0048208"(COPII vesicle coating)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0071630"(nuclear protein quality control by the ubiquitin-proteasome system)|go:"GO:0072576"(liver morphogenesis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:1901992"(positive regulation of mitotic cell cycle phase transition)|interpro:IPR001373(Cullin, N-terminal region)|interpro:IPR016157(Cullin, conserved site)|interpro:IPR016158(Cullin homology)|interpro:IPR016159(Cullin repeat-like)|interpro:IPR019559|interpro:IPR036317|interpro:IPR036388|interpro:IPR036390|mint:Q13618|rcsb pdb:2MYL|rcsb pdb:2MYM|rcsb pdb:4AP2|rcsb pdb:4APF|rcsb pdb:4EOZ|rcsb pdb:4HXI|rcsb pdb:5NLB|rcsb pdb:6I2M|reactome:R-HSA-4641258|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-8932339|reactome:R-HSA-8951664|reactome:R-HSA-9013418|reactome:R-HSA-9013422|reactome:R-HSA-9706019|reactome:R-HSA-983168 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2020/10/21 rogid:hyuYyAujJCJtbfS2tJ+UgH7jWP89606 rogid:xI/8pHB9nckOW629STOqKba4KzQ9606 intact-crc:B58AF288F9C81A77|rigid:/fWQJTQK1fD0fpKu4c/6K/d+bMo false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q7L5N1 uniprotkb:Q96M94 intact:EBI-486838|uniprotkb:O15387|uniprotkb:A4D2A3|ensembl:ENSP00000304102 intact:EBI-2510129|ensembl:ENSP00000332791|uniprotkb:Q9C0I6|uniprotkb:Q32MN3|uniprotkb:Q96BM6|uniprotkb:Q8NDA3 psi-mi:csn6_human(display_long)|uniprotkb:COPS6(gene name)|psi-mi:COPS6(display_short)|uniprotkb:CSN6(gene name synonym)|uniprotkb:HVIP(gene name synonym)|uniprotkb:JAB1-containing signalosome subunit 6(gene name synonym)|uniprotkb:Vpr-interacting protein(gene name synonym)|uniprotkb:MOV34 homolog(gene name synonym) psi-mi:klh15_human(display_long)|uniprotkb:KLHL15(gene name)|psi-mi:KLHL15(display_short)|uniprotkb:KIAA1677(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510262|imex:IM-12079-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006824.2|ensembl:ENSG00000168090(gene)|ensembl:ENST00000303904(transcript)|go:"GO:0000338"(protein deneddylation)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070122"(isopeptidase activity)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR033859|interpro:IPR024969|interpro:IPR037518|mint:Q7L5N1|rcsb pdb:4D10|rcsb pdb:4D18|rcsb pdb:4QFT|rcsb pdb:4R14|rcsb pdb:4WSN|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|reactome:R-HSA-5696394|reactome:R-HSA-6781823|reactome:R-HSA-8856825|reactome:R-HSA-8951664|dip:DIP-32655N ensembl:ENSG00000174010(gene)|ensembl:ENST00000328046(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0071630"(nuclear protein quality control by the ubiquitin-proteasome system)|go:"GO:2000042"(negative regulation of double-strand break repair via homologous recombination)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR011705(BTB/Kelch-associated)|interpro:IPR015915(Kelch-type beta propeller)|interpro:IPR017096(Kelch-like protein, gigaxonin)|interpro:IPR030597|refseq:NP_085127.2|refseq:XP_006724581.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2020/10/21 rogid:hyuYyAujJCJtbfS2tJ+UgH7jWP89606 rogid:Xkm72585iSVnSMqN1b0XM79Pd2g9606 intact-crc:B58AF288F9C81A77|rigid:/fWQJTQK1fD0fpKu4c/6K/d+bMo false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q7L5N1 uniprotkb:Q8WXC6 intact:EBI-486838|uniprotkb:O15387|uniprotkb:A4D2A3|ensembl:ENSP00000304102 intact:EBI-2510257|uniprotkb:Q8N110|ensembl:ENSP00000475979 psi-mi:csn6_human(display_long)|uniprotkb:COPS6(gene name)|psi-mi:COPS6(display_short)|uniprotkb:CSN6(gene name synonym)|uniprotkb:HVIP(gene name synonym)|uniprotkb:JAB1-containing signalosome subunit 6(gene name synonym)|uniprotkb:Vpr-interacting protein(gene name synonym)|uniprotkb:MOV34 homolog(gene name synonym) psi-mi:csn9_human(display_long)|uniprotkb:COPS9(gene name)|psi-mi:COPS9(display_short)|uniprotkb:CSN acidic protein(gene name synonym)|uniprotkb:MYEOV2(gene name synonym)|uniprotkb:Myeloma-overexpressed gene 2 protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510262|imex:IM-12079-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006824.2|ensembl:ENSG00000168090(gene)|ensembl:ENST00000303904(transcript)|go:"GO:0000338"(protein deneddylation)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070122"(isopeptidase activity)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR033859|interpro:IPR024969|interpro:IPR037518|mint:Q7L5N1|rcsb pdb:4D10|rcsb pdb:4D18|rcsb pdb:4QFT|rcsb pdb:4R14|rcsb pdb:4WSN|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|reactome:R-HSA-5696394|reactome:R-HSA-6781823|reactome:R-HSA-8856825|reactome:R-HSA-8951664|dip:DIP-32655N refseq:NP_001156896.1|refseq:NP_612209.1|ensembl:ENSG00000172428(gene)|ensembl:ENST00000607357(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0034644"(cellular response to UV)|go:"GO:0051220"(cytoplasmic sequestering of protein)|go:"GO:2000435"(negative regulation of protein neddylation)|interpro:IPR029391 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2020/10/21 rogid:hyuYyAujJCJtbfS2tJ+UgH7jWP89606 rogid:Ma2mlUpfjM/BNSiVuV9+6tnomtQ9606 intact-crc:B58AF288F9C81A77|rigid:/fWQJTQK1fD0fpKu4c/6K/d+bMo false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q7L5N1 uniprotkb:P15374 intact:EBI-486838|uniprotkb:O15387|uniprotkb:A4D2A3|ensembl:ENSP00000304102 intact:EBI-954554|uniprotkb:Q5TBK8|uniprotkb:Q6IBE9|ensembl:ENSP00000366819|uniprotkb:B2R970 psi-mi:csn6_human(display_long)|uniprotkb:COPS6(gene name)|psi-mi:COPS6(display_short)|uniprotkb:CSN6(gene name synonym)|uniprotkb:HVIP(gene name synonym)|uniprotkb:JAB1-containing signalosome subunit 6(gene name synonym)|uniprotkb:Vpr-interacting protein(gene name synonym)|uniprotkb:MOV34 homolog(gene name synonym) psi-mi:uchl3_human(display_long)|uniprotkb:Ubiquitin thioesterase L3(gene name synonym)|uniprotkb:UCHL3(gene name)|psi-mi:UCHL3(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510262|imex:IM-12079-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006824.2|ensembl:ENSG00000168090(gene)|ensembl:ENST00000303904(transcript)|go:"GO:0000338"(protein deneddylation)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070122"(isopeptidase activity)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR033859|interpro:IPR024969|interpro:IPR037518|mint:Q7L5N1|rcsb pdb:4D10|rcsb pdb:4D18|rcsb pdb:4QFT|rcsb pdb:4R14|rcsb pdb:4WSN|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|reactome:R-HSA-5696394|reactome:R-HSA-6781823|reactome:R-HSA-8856825|reactome:R-HSA-8951664|dip:DIP-32655N refseq:NP_001257881.1|refseq:NP_005993.1|ensembl:ENSG00000118939(gene)|ensembl:ENST00000377595(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008233"(peptidase activity)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019784"(NEDD8-specific protease activity)|go:"GO:0030163"(protein catabolic process)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043687"(post-translational protein modification)|interpro:IPR001578(Peptidase C12, ubiquitin carboxyl-terminal hydrolase 1)|interpro:IPR036959|interpro:IPR038765|rcsb pdb:1UCH|rcsb pdb:1XD3|rcsb pdb:6ISU|rcsb pdb:6QML|reactome:R-HSA-5689603|reactome:R-HSA-8866652|reactome:R-HSA-8951664|dip:DIP-29135N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2020/10/21 rogid:hyuYyAujJCJtbfS2tJ+UgH7jWP89606 rogid:cPnctBpxrgvBKBSaQmhCsyd2nRM9606 intact-crc:B58AF288F9C81A77|rigid:/fWQJTQK1fD0fpKu4c/6K/d+bMo false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q7L5N1 uniprotkb:Q13616 intact:EBI-486838|uniprotkb:O15387|uniprotkb:A4D2A3|ensembl:ENSP00000304102 intact:EBI-359390|uniprotkb:O60719|uniprotkb:Q08AL6|uniprotkb:Q8IYW1|uniprotkb:D3DWG3|ensembl:ENSP00000326804|ensembl:ENSP00000387160|ensembl:ENSP00000473318|ensembl:ENSP00000499255|ensembl:ENSP00000499277|ensembl:ENSP00000499398 psi-mi:csn6_human(display_long)|uniprotkb:COPS6(gene name)|psi-mi:COPS6(display_short)|uniprotkb:CSN6(gene name synonym)|uniprotkb:HVIP(gene name synonym)|uniprotkb:JAB1-containing signalosome subunit 6(gene name synonym)|uniprotkb:Vpr-interacting protein(gene name synonym)|uniprotkb:MOV34 homolog(gene name synonym) psi-mi:cul1_human(display_long)|uniprotkb:CUL1(gene name)|psi-mi:CUL1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510262|imex:IM-12079-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006824.2|ensembl:ENSG00000168090(gene)|ensembl:ENST00000303904(transcript)|go:"GO:0000338"(protein deneddylation)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070122"(isopeptidase activity)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR033859|interpro:IPR024969|interpro:IPR037518|mint:Q7L5N1|rcsb pdb:4D10|rcsb pdb:4D18|rcsb pdb:4QFT|rcsb pdb:4R14|rcsb pdb:4WSN|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|reactome:R-HSA-5696394|reactome:R-HSA-6781823|reactome:R-HSA-8856825|reactome:R-HSA-8951664|dip:DIP-32655N refseq:NP_003583.2|rcsb pdb:6WCQ|rcsb pdb:7B5L|rcsb pdb:7B5M|rcsb pdb:7B5N|rcsb pdb:7B5R|rcsb pdb:7B5S|reactome:R-HSA-1169091|reactome:R-HSA-1170546|reactome:R-HSA-174113|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-2122947|reactome:R-HSA-2565942|reactome:R-HSA-2644606|reactome:R-HSA-2644607|reactome:R-HSA-2871837|reactome:R-HSA-2894862|reactome:R-HSA-400253|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5676590|reactome:R-HSA-5684264|reactome:R-HSA-68949|reactome:R-HSA-69231|reactome:R-HSA-8854050|reactome:R-HSA-8939902|reactome:R-HSA-8951664|reactome:R-HSA-9020702|reactome:R-HSA-917937|reactome:R-HSA-9604323|reactome:R-HSA-9708530|reactome:R-HSA-983168|refseq:XP_011514931.1|refseq:XP_011514932.1|refseq:XP_011514933.1|refseq:XP_011514934.1|ensembl:ENSG00000055130(gene)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|ensembl:ENST00000325222(transcript)|ensembl:ENST00000409469(transcript)|ensembl:ENST00000602748(transcript)|ensembl:ENST00000662716(transcript)|ensembl:ENST00000663044(transcript)|ensembl:ENST00000665936(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:1990452"(Parkin-FBXW7-Cul1 ubiquitin ligase complex)|interpro:IPR001373(Cullin, N-terminal region)|interpro:IPR016157(Cullin, conserved site)|interpro:IPR016158(Cullin homology)|interpro:IPR016159(Cullin repeat-like)|interpro:IPR019559|interpro:IPR036317|interpro:IPR036388|interpro:IPR036390|mint:Q13616|rcsb pdb:1LDJ|rcsb pdb:1LDK|rcsb pdb:1U6G|rcsb pdb:3RTR|rcsb pdb:3TDU|rcsb pdb:3TDZ|rcsb pdb:4F52|rcsb pdb:4P5O|rcsb pdb:5V89|rcsb pdb:6TTU|refseq:XP_005250117.1|dip:DIP-17013N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2020/10/21 rogid:hyuYyAujJCJtbfS2tJ+UgH7jWP89606 rogid:OAZP+ifWW3eEnQKb937ww9s1fMQ9606 intact-crc:B58AF288F9C81A77|rigid:/fWQJTQK1fD0fpKu4c/6K/d+bMo false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q7L5N1 uniprotkb:Q9UBW8 intact:EBI-486838|uniprotkb:O15387|uniprotkb:A4D2A3|ensembl:ENSP00000304102 intact:EBI-712982|ensembl:ENSP00000229251|ensembl:ENSP00000438115|ensembl:ENSP00000438363|ensembl:ENSP00000441852|ensembl:ENSP00000446039|uniprotkb:Q9NVX3|uniprotkb:Q9UJW4|uniprotkb:A8K9A6 psi-mi:csn6_human(display_long)|uniprotkb:COPS6(gene name)|psi-mi:COPS6(display_short)|uniprotkb:CSN6(gene name synonym)|uniprotkb:HVIP(gene name synonym)|uniprotkb:JAB1-containing signalosome subunit 6(gene name synonym)|uniprotkb:Vpr-interacting protein(gene name synonym)|uniprotkb:MOV34 homolog(gene name synonym) psi-mi:csn7a_human(display_long)|uniprotkb:JAB1-containing signalosome subunit 7a(gene name synonym)|uniprotkb:Dermal papilla-derived protein 10(gene name synonym)|uniprotkb:COPS7A(gene name)|psi-mi:COPS7A(display_short)|uniprotkb:CSN7A(gene name synonym)|uniprotkb:DERP10(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510262|imex:IM-12079-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006824.2|ensembl:ENSG00000168090(gene)|ensembl:ENST00000303904(transcript)|go:"GO:0000338"(protein deneddylation)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070122"(isopeptidase activity)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR033859|interpro:IPR024969|interpro:IPR037518|mint:Q7L5N1|rcsb pdb:4D10|rcsb pdb:4D18|rcsb pdb:4QFT|rcsb pdb:4R14|rcsb pdb:4WSN|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|reactome:R-HSA-5696394|reactome:R-HSA-6781823|reactome:R-HSA-8856825|reactome:R-HSA-8951664|dip:DIP-32655N ensembl:ENSG00000111652(gene)|ensembl:ENST00000229251(transcript)|ensembl:ENST00000534877(transcript)|ensembl:ENST00000534947(transcript)|ensembl:ENST00000539735(transcript)|ensembl:ENST00000543155(transcript)|go:"GO:0000338"(protein deneddylation)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010387"(COP9 signalosome assembly)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR037757|interpro:IPR041481|mint:Q9UBW8|rcsb pdb:4D10|rcsb pdb:4D18|rcsb pdb:4WSN|reactome:R-HSA-5696394|reactome:R-HSA-6781823|reactome:R-HSA-8856825|reactome:R-HSA-8951664|refseq:NP_001157565.1|refseq:NP_001157566.1|refseq:NP_001157567.1|refseq:NP_057403.1|refseq:XP_005253751.1|dip:DIP-53412N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2020/10/21 rogid:hyuYyAujJCJtbfS2tJ+UgH7jWP89606 rogid:KT1zw5OuZthyscvNa/4lW1iJz2Q9606 intact-crc:B58AF288F9C81A77|rigid:/fWQJTQK1fD0fpKu4c/6K/d+bMo false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q7L5N1 uniprotkb:Q99627 intact:EBI-486838|uniprotkb:O15387|uniprotkb:A4D2A3|ensembl:ENSP00000304102 intact:EBI-2510102|ensembl:ENSP00000346340|uniprotkb:A8K1H6|uniprotkb:Q53QS9 psi-mi:csn6_human(display_long)|uniprotkb:COPS6(gene name)|psi-mi:COPS6(display_short)|uniprotkb:CSN6(gene name synonym)|uniprotkb:HVIP(gene name synonym)|uniprotkb:JAB1-containing signalosome subunit 6(gene name synonym)|uniprotkb:Vpr-interacting protein(gene name synonym)|uniprotkb:MOV34 homolog(gene name synonym) psi-mi:csn8_human(display_long)|uniprotkb:COPS8(gene name)|psi-mi:COPS8(display_short)|uniprotkb:CSN8(gene name synonym)|uniprotkb:JAB1-containing signalosome subunit 8(gene name synonym)|uniprotkb:COP9 homolog(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510262|imex:IM-12079-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006824.2|ensembl:ENSG00000168090(gene)|ensembl:ENST00000303904(transcript)|go:"GO:0000338"(protein deneddylation)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070122"(isopeptidase activity)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR033859|interpro:IPR024969|interpro:IPR037518|mint:Q7L5N1|rcsb pdb:4D10|rcsb pdb:4D18|rcsb pdb:4QFT|rcsb pdb:4R14|rcsb pdb:4WSN|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|reactome:R-HSA-5696394|reactome:R-HSA-6781823|reactome:R-HSA-8856825|reactome:R-HSA-8951664|dip:DIP-32655N ensembl:ENSG00000198612(gene)|ensembl:ENST00000354371(transcript)|go:"GO:0000338"(protein deneddylation)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010387"(COP9 signalosome assembly)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR033205|interpro:IPR033464|mint:Q99627|rcsb pdb:4D10|rcsb pdb:4D18|rcsb pdb:4WSN|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|rcsb pdb:6R7N|reactome:R-HSA-5696394|reactome:R-HSA-6781823|reactome:R-HSA-8856825|reactome:R-HSA-8951664|go:"GO:0006468"(protein phosphorylation)|refseq:NP_006701.1|refseq:NP_937832.1|dip:DIP-42075N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2020/10/21 rogid:hyuYyAujJCJtbfS2tJ+UgH7jWP89606 rogid:3L+8IdjEw+ZC5MERztdPAY2ww389606 intact-crc:B58AF288F9C81A77|rigid:/fWQJTQK1fD0fpKu4c/6K/d+bMo false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q7L5N1 uniprotkb:Q8NEZ5 intact:EBI-486838|uniprotkb:O15387|uniprotkb:A4D2A3|ensembl:ENSP00000304102 intact:EBI-2510137|ensembl:ENSP00000307833|uniprotkb:Q9H824|uniprotkb:Q6PIL5|uniprotkb:Q9UKC0|uniprotkb:Q0D2P8|uniprotkb:Q8IXW3 psi-mi:csn6_human(display_long)|uniprotkb:COPS6(gene name)|psi-mi:COPS6(display_short)|uniprotkb:CSN6(gene name synonym)|uniprotkb:HVIP(gene name synonym)|uniprotkb:JAB1-containing signalosome subunit 6(gene name synonym)|uniprotkb:Vpr-interacting protein(gene name synonym)|uniprotkb:MOV34 homolog(gene name synonym) psi-mi:fbx22_human(display_long)|uniprotkb:FBXO22(gene name)|psi-mi:FBXO22(display_short)|uniprotkb:FBX22(gene name synonym)|uniprotkb:F-box protein FBX22p44(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510262|imex:IM-12079-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006824.2|ensembl:ENSG00000168090(gene)|ensembl:ENST00000303904(transcript)|go:"GO:0000338"(protein deneddylation)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070122"(isopeptidase activity)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR033859|interpro:IPR024969|interpro:IPR037518|mint:Q7L5N1|rcsb pdb:4D10|rcsb pdb:4D18|rcsb pdb:4QFT|rcsb pdb:4R14|rcsb pdb:4WSN|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|reactome:R-HSA-5696394|reactome:R-HSA-6781823|reactome:R-HSA-8856825|reactome:R-HSA-8951664|dip:DIP-32655N ensembl:ENSG00000167196(gene)|ensembl:ENST00000308275(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0030018"(Z disc)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR019494|interpro:IPR036047|reactome:R-HSA-8951664|reactome:R-HSA-983168|refseq:XP_011519749.1|refseq:NP_036302.1|refseq:NP_671717.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2020/10/21 rogid:hyuYyAujJCJtbfS2tJ+UgH7jWP89606 rogid:hOnBb3SK/OM+oGU8RdxmUb8MVDE9606 intact-crc:B58AF288F9C81A77|rigid:/fWQJTQK1fD0fpKu4c/6K/d+bMo false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q7L5N1 uniprotkb:Q9P2J3 intact:EBI-486838|uniprotkb:O15387|uniprotkb:A4D2A3|ensembl:ENSP00000304102 intact:EBI-2510152|ensembl:ENSP00000351933|uniprotkb:Q8TCQ2 psi-mi:csn6_human(display_long)|uniprotkb:COPS6(gene name)|psi-mi:COPS6(display_short)|uniprotkb:CSN6(gene name synonym)|uniprotkb:HVIP(gene name synonym)|uniprotkb:JAB1-containing signalosome subunit 6(gene name synonym)|uniprotkb:Vpr-interacting protein(gene name synonym)|uniprotkb:MOV34 homolog(gene name synonym) psi-mi:klhl9_human(display_long)|uniprotkb:KLHL9(gene name)|psi-mi:KLHL9(display_short)|uniprotkb:KIAA1354(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510262|imex:IM-12079-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006824.2|ensembl:ENSG00000168090(gene)|ensembl:ENST00000303904(transcript)|go:"GO:0000338"(protein deneddylation)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070122"(isopeptidase activity)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR033859|interpro:IPR024969|interpro:IPR037518|mint:Q7L5N1|rcsb pdb:4D10|rcsb pdb:4D18|rcsb pdb:4QFT|rcsb pdb:4R14|rcsb pdb:4WSN|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|reactome:R-HSA-5696394|reactome:R-HSA-6781823|reactome:R-HSA-8856825|reactome:R-HSA-8951664|dip:DIP-32655N ensembl:ENSG00000198642(gene)|ensembl:ENST00000359039(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0007049"(cell cycle)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030496"(midbody)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0051301"(cell division)|go:"GO:0097602"(cullin family protein binding)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR011705(BTB/Kelch-associated)|interpro:IPR015915(Kelch-type beta propeller)|interpro:IPR017096(Kelch-like protein, gigaxonin)|reactome:R-HSA-8951664|reactome:R-HSA-983168|refseq:NP_061335.1|dip:DIP-53514N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2020/10/21 rogid:hyuYyAujJCJtbfS2tJ+UgH7jWP89606 rogid:BBlUawWo6f4qKrbRHeZp87E+DTo9606 intact-crc:B58AF288F9C81A77|rigid:/fWQJTQK1fD0fpKu4c/6K/d+bMo false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q7L5N1 uniprotkb:Q13619 intact:EBI-486838|uniprotkb:O15387|uniprotkb:A4D2A3|ensembl:ENSP00000304102 intact:EBI-456106|uniprotkb:O75834|uniprotkb:Q589T6|uniprotkb:Q5TC62|uniprotkb:Q6UP08|uniprotkb:Q9UP17|uniprotkb:A2A2W2|ensembl:ENSP00000364589 psi-mi:csn6_human(display_long)|uniprotkb:COPS6(gene name)|psi-mi:COPS6(display_short)|uniprotkb:CSN6(gene name synonym)|uniprotkb:HVIP(gene name synonym)|uniprotkb:JAB1-containing signalosome subunit 6(gene name synonym)|uniprotkb:Vpr-interacting protein(gene name synonym)|uniprotkb:MOV34 homolog(gene name synonym) psi-mi:cul4a_human(display_long)|uniprotkb:CUL4A(gene name)|psi-mi:CUL4A(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510262|imex:IM-12079-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006824.2|ensembl:ENSG00000168090(gene)|ensembl:ENST00000303904(transcript)|go:"GO:0000338"(protein deneddylation)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070122"(isopeptidase activity)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR033859|interpro:IPR024969|interpro:IPR037518|mint:Q7L5N1|rcsb pdb:4D10|rcsb pdb:4D18|rcsb pdb:4QFT|rcsb pdb:4R14|rcsb pdb:4WSN|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|reactome:R-HSA-5696394|reactome:R-HSA-6781823|reactome:R-HSA-8856825|reactome:R-HSA-8951664|dip:DIP-32655N refseq:NP_001008895.1|refseq:NP_003580.1|refseq:NP_001265442.1|refseq:XP_011535825.1|dip:DIP-31610N|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042254"(ribosome biogenesis)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0048511"(rhythmic process)|go:"GO:0051246"(regulation of protein metabolic process)|go:"GO:0080008"(Cul4-RING E3 ubiquitin ligase complex)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000001"(regulation of DNA damage checkpoint)|go:"GO:2000819"(regulation of nucleotide-excision repair)|interpro:IPR001373(Cullin, N-terminal region)|interpro:IPR016157(Cullin, conserved site)|interpro:IPR016158(Cullin homology)|interpro:IPR016159(Cullin repeat-like)|interpro:IPR019559|interpro:IPR036317|interpro:IPR036388|interpro:IPR036390|mint:Q13619|rcsb pdb:2HYE|rcsb pdb:4A0K|reactome:R-HSA-110314|reactome:R-HSA-5696394|reactome:R-HSA-5696395|reactome:R-HSA-5696400|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-8951664|ensembl:ENSG00000139842(gene)|ensembl:ENST00000375440(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030853"(negative regulation of granulocyte differentiation)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031464"(Cul4A-RING E3 ubiquitin ligase complex) psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2020/10/21 rogid:hyuYyAujJCJtbfS2tJ+UgH7jWP89606 rogid:xYRRxjpO/9qqeXtq9dfACAdqyM89606 intact-crc:B58AF288F9C81A77|rigid:/fWQJTQK1fD0fpKu4c/6K/d+bMo false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q7L5N1 uniprotkb:Q9H078 intact:EBI-486838|uniprotkb:O15387|uniprotkb:A4D2A3|ensembl:ENSP00000304102 intact:EBI-2107221|uniprotkb:Q8ND11|uniprotkb:Q9H8Y0|uniprotkb:B4DXW4|uniprotkb:B4DXJ7|uniprotkb:B4DXP7|uniprotkb:E7EWN6|uniprotkb:F8W7P6|ensembl:ENSP00000294053 psi-mi:csn6_human(display_long)|uniprotkb:COPS6(gene name)|psi-mi:COPS6(display_short)|uniprotkb:CSN6(gene name synonym)|uniprotkb:HVIP(gene name synonym)|uniprotkb:JAB1-containing signalosome subunit 6(gene name synonym)|uniprotkb:Vpr-interacting protein(gene name synonym)|uniprotkb:MOV34 homolog(gene name synonym) psi-mi:clpb_human(display_long)|uniprotkb:CLPB(gene name)|psi-mi:CLPB(display_short)|uniprotkb:HSP78(gene name synonym)|uniprotkb:SKD3(gene name synonym)|uniprotkb:Suppressor of potassium transport defect 3(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510262|imex:IM-12079-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006824.2|ensembl:ENSG00000168090(gene)|ensembl:ENST00000303904(transcript)|go:"GO:0000338"(protein deneddylation)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070122"(isopeptidase activity)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR033859|interpro:IPR024969|interpro:IPR037518|mint:Q7L5N1|rcsb pdb:4D10|rcsb pdb:4D18|rcsb pdb:4QFT|rcsb pdb:4R14|rcsb pdb:4WSN|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|reactome:R-HSA-5696394|reactome:R-HSA-6781823|reactome:R-HSA-8856825|reactome:R-HSA-8951664|dip:DIP-32655N refseq:NP_110440.1|refseq:NP_001245321.1|refseq:NP_001245322.1|refseq:NP_001245323.1|ensembl:ENSG00000162129(gene)|ensembl:ENST00000294053(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0034605"(cellular response to heat)|go:"GO:0039529"(RIG-I signaling pathway)|go:"GO:0140374"(antiviral innate immune response)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001270(Chaperonin clpA/B)|interpro:IPR002110(Ankyrin)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR019489|interpro:IPR020683|interpro:IPR027417|interpro:IPR036770|mint:Q9H078 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2020/10/21 rogid:hyuYyAujJCJtbfS2tJ+UgH7jWP89606 rogid:QqIOYOITwDC+c8kKtMGBHa/0Tjk9606 intact-crc:B58AF288F9C81A77|rigid:/fWQJTQK1fD0fpKu4c/6K/d+bMo false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q7L5N1 uniprotkb:Q9H4M3 intact:EBI-486838|uniprotkb:O15387|uniprotkb:A4D2A3|ensembl:ENSP00000304102 intact:EBI-2322644|uniprotkb:Q5TGX2|uniprotkb:Q5TGX4|uniprotkb:Q5TGX5|uniprotkb:Q68DJ9|uniprotkb:Q8WWY2|uniprotkb:B3KNZ2|uniprotkb:B7Z743|ensembl:ENSP00000251547|ensembl:ENSP00000365961 psi-mi:csn6_human(display_long)|uniprotkb:COPS6(gene name)|psi-mi:COPS6(display_short)|uniprotkb:CSN6(gene name synonym)|uniprotkb:HVIP(gene name synonym)|uniprotkb:JAB1-containing signalosome subunit 6(gene name synonym)|uniprotkb:Vpr-interacting protein(gene name synonym)|uniprotkb:MOV34 homolog(gene name synonym) psi-mi:fbx44_human(display_long)|uniprotkb:FBXO44(gene name)|psi-mi:FBXO44(display_short)|uniprotkb:FBG3(gene name synonym)|uniprotkb:FBX30(gene name synonym)|uniprotkb:FBX44(gene name synonym)|uniprotkb:FBX6A(gene name synonym)|uniprotkb:FBXO6A(gene name synonym)|uniprotkb:F-box/G-domain protein 3(gene name synonym)|uniprotkb:F-box protein FBX30(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510262|imex:IM-12079-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006824.2|ensembl:ENSG00000168090(gene)|ensembl:ENST00000303904(transcript)|go:"GO:0000338"(protein deneddylation)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070122"(isopeptidase activity)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR033859|interpro:IPR024969|interpro:IPR037518|mint:Q7L5N1|rcsb pdb:4D10|rcsb pdb:4D18|rcsb pdb:4QFT|rcsb pdb:4R14|rcsb pdb:4WSN|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|reactome:R-HSA-5696394|reactome:R-HSA-6781823|reactome:R-HSA-8856825|reactome:R-HSA-8951664|dip:DIP-32655N refseq:NP_001291720.1|refseq:NP_001291719.1|refseq:XP_006711108.1|refseq:NP_001014765.1|refseq:NP_149438.2|refseq:NP_904319.1|refseq:NP_904320.1|refseq:XP_016858332.1|refseq:XP_016858333.1|ensembl:ENSG00000132879(gene)|ensembl:ENST00000251547(transcript)|ensembl:ENST00000376770(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006516"(glycoprotein catabolic process)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR007397(F-box associated region)|interpro:IPR008979(Galactose-binding like)|interpro:IPR036047|interpro:IPR039752|rcsb pdb:3WSO|rcsb pdb:5B4N|reactome:R-HSA-8951664|reactome:R-HSA-983168 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2020/10/21 rogid:hyuYyAujJCJtbfS2tJ+UgH7jWP89606 rogid:4pBdxSUZxIgZKD5rZXETdYIJ5UU9606 intact-crc:B58AF288F9C81A77|rigid:/fWQJTQK1fD0fpKu4c/6K/d+bMo false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q7L5N1 uniprotkb:Q9Y3I1 intact:EBI-486838|uniprotkb:O15387|uniprotkb:A4D2A3|ensembl:ENSP00000304102 intact:EBI-1161222|uniprotkb:Q5TGC4|uniprotkb:Q96HM6|uniprotkb:Q9UF21|uniprotkb:Q9UKT2|uniprotkb:B4DNB3|ensembl:ENSP00000266087|uniprotkb:B4DWX5|uniprotkb:Q5TI86 psi-mi:csn6_human(display_long)|uniprotkb:COPS6(gene name)|psi-mi:COPS6(display_short)|uniprotkb:CSN6(gene name synonym)|uniprotkb:HVIP(gene name synonym)|uniprotkb:JAB1-containing signalosome subunit 6(gene name synonym)|uniprotkb:Vpr-interacting protein(gene name synonym)|uniprotkb:MOV34 homolog(gene name synonym) psi-mi:fbx7_human(display_long)|uniprotkb:FBXO7(gene name)|psi-mi:FBXO7(display_short)|uniprotkb:FBX7(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510262|imex:IM-12079-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006824.2|ensembl:ENSG00000168090(gene)|ensembl:ENST00000303904(transcript)|go:"GO:0000338"(protein deneddylation)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070122"(isopeptidase activity)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR033859|interpro:IPR024969|interpro:IPR037518|mint:Q7L5N1|rcsb pdb:4D10|rcsb pdb:4D18|rcsb pdb:4QFT|rcsb pdb:4R14|rcsb pdb:4WSN|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|reactome:R-HSA-5696394|reactome:R-HSA-6781823|reactome:R-HSA-8856825|reactome:R-HSA-8951664|dip:DIP-32655N refseq:NP_001028196.1|refseq:NP_036311.3|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040012"(regulation of locomotion)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045620"(negative regulation of lymphocyte differentiation)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0097409"(glial cytoplasmic inclusion)|go:"GO:0097414"(classical Lewy body)|go:"GO:0097462"(Lewy neurite)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0016567"(protein ubiquitination)|go:"GO:1903599"(positive regulation of autophagy of mitochondrion)|go:"GO:1990037"(Lewy body core)|go:"GO:1990038"(Lewy body corona)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR021625|interpro:IPR029071|interpro:IPR036047|mint:Q9Y3I1|rcsb pdb:4L9C|rcsb pdb:4L9H|reactome:R-HSA-8951664|reactome:R-HSA-983168|go:"GO:1903208"(negative regulation of hydrogen peroxide-induced neuron death)|ensembl:ENSG00000100225(gene)|ensembl:ENST00000266087(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|refseq:NP_001244919.1|dip:DIP-36125N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2020/10/21 rogid:hyuYyAujJCJtbfS2tJ+UgH7jWP89606 rogid:i2Mqtw28fJTLURYC+gwr6bcjBoY9606 intact-crc:B58AF288F9C81A77|rigid:/fWQJTQK1fD0fpKu4c/6K/d+bMo false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q7L5N1 uniprotkb:Q13620 intact:EBI-486838|uniprotkb:O15387|uniprotkb:A4D2A3|ensembl:ENSP00000304102 intact:EBI-456067|uniprotkb:Q6PIE4|uniprotkb:Q6UP07|uniprotkb:B3KVX4|uniprotkb:B7Z5K8|uniprotkb:Q7Z673|uniprotkb:Q9BY37|uniprotkb:Q9UEB7|uniprotkb:Q9UED7|uniprotkb:B1APK5|ensembl:ENSP00000505084|ensembl:ENSP00000505176|ensembl:ENSP00000506259 psi-mi:csn6_human(display_long)|uniprotkb:COPS6(gene name)|psi-mi:COPS6(display_short)|uniprotkb:CSN6(gene name synonym)|uniprotkb:HVIP(gene name synonym)|uniprotkb:JAB1-containing signalosome subunit 6(gene name synonym)|uniprotkb:Vpr-interacting protein(gene name synonym)|uniprotkb:MOV34 homolog(gene name synonym) psi-mi:cul4b_human(display_long)|uniprotkb:CUL4B(gene name)|psi-mi:CUL4B(display_short)|uniprotkb:KIAA0695(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510262|imex:IM-12079-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006824.2|ensembl:ENSG00000168090(gene)|ensembl:ENST00000303904(transcript)|go:"GO:0000338"(protein deneddylation)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070122"(isopeptidase activity)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR033859|interpro:IPR024969|interpro:IPR037518|mint:Q7L5N1|rcsb pdb:4D10|rcsb pdb:4D18|rcsb pdb:4QFT|rcsb pdb:4R14|rcsb pdb:4WSN|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|reactome:R-HSA-5696394|reactome:R-HSA-6781823|reactome:R-HSA-8856825|reactome:R-HSA-8951664|dip:DIP-32655N refseq:NP_001073341.1|refseq:NP_003579.3|ensembl:ENST00000371322|ensembl:ENSP00000360373|ensembl:ENST00000371323|ensembl:ENSP00000360374|ensembl:ENSP00000505084|ensembl:ENSP00000506259|ensembl:ENSP00000505176|refseq:XP_011529702.1|dip:DIP-31609N|ensembl:ENSG00000158290(gene)|ensembl:ENST00000680673(transcript)|ensembl:ENST00000681253(transcript)|ensembl:ENST00000681652(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031175"(neuron projection development)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031465"(Cul4B-RING E3 ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035518"(histone H2A monoubiquitination)|go:"GO:0042254"(ribosome biogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070914"(UV-damage excision repair)|reactome:R-HSA-5696394|reactome:R-HSA-5696395|reactome:R-HSA-5696400|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-8951664|go:"GO:0080008"(Cul4-RING E3 ubiquitin ligase complex)|interpro:IPR001373(Cullin, N-terminal region)|interpro:IPR016157(Cullin, conserved site)|interpro:IPR016158(Cullin homology)|interpro:IPR016159(Cullin repeat-like)|interpro:IPR019559|interpro:IPR033044|interpro:IPR036317|interpro:IPR036388|interpro:IPR036390|mint:Q13620|rcsb pdb:2DO7|rcsb pdb:4A0C|rcsb pdb:4A0L|rcsb pdb:4A64|reactome:R-HSA-110314 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2020/10/21 rogid:hyuYyAujJCJtbfS2tJ+UgH7jWP89606 rogid:D75aMBt3GaBdpBt5Mxsxk7yiRVg9606 intact-crc:B58AF288F9C81A77|rigid:/fWQJTQK1fD0fpKu4c/6K/d+bMo false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q7L5N1 uniprotkb:Q13617 intact:EBI-486838|uniprotkb:O15387|uniprotkb:A4D2A3|ensembl:ENSP00000304102 intact:EBI-456179|uniprotkb:O00200|uniprotkb:Q5T2B6|uniprotkb:Q9UNF9|uniprotkb:D3DRY6|uniprotkb:B3KT95|uniprotkb:B7Z6K8|uniprotkb:G3V1S2|ensembl:ENSP00000363881|ensembl:ENSP00000363883|ensembl:ENSP00000501215|ensembl:ENSP00000363880 psi-mi:csn6_human(display_long)|uniprotkb:COPS6(gene name)|psi-mi:COPS6(display_short)|uniprotkb:CSN6(gene name synonym)|uniprotkb:HVIP(gene name synonym)|uniprotkb:JAB1-containing signalosome subunit 6(gene name synonym)|uniprotkb:Vpr-interacting protein(gene name synonym)|uniprotkb:MOV34 homolog(gene name synonym) psi-mi:cul2_human(display_long)|uniprotkb:CUL2(gene name)|psi-mi:CUL2(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510262|imex:IM-12079-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006824.2|ensembl:ENSG00000168090(gene)|ensembl:ENST00000303904(transcript)|go:"GO:0000338"(protein deneddylation)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070122"(isopeptidase activity)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR033859|interpro:IPR024969|interpro:IPR037518|mint:Q7L5N1|rcsb pdb:4D10|rcsb pdb:4D18|rcsb pdb:4QFT|rcsb pdb:4R14|rcsb pdb:4WSN|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|reactome:R-HSA-5696394|reactome:R-HSA-6781823|reactome:R-HSA-8856825|reactome:R-HSA-8951664|dip:DIP-32655N refseq:NP_001185706.1|refseq:NP_001185707.1|refseq:NP_001185708.1|refseq:NP_003582.2|refseq:XP_011518049.1|dip:DIP-31612N|ensembl:ENST00000374748(transcript)|ensembl:ENST00000374749(transcript)|ensembl:ENST00000374751(transcript)|ensembl:ENST00000673636(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0030891"(VCB complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031462"(Cul2-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|interpro:IPR001373(Cullin, N-terminal region)|interpro:IPR016157(Cullin, conserved site)|interpro:IPR016158(Cullin homology)|interpro:IPR016159(Cullin repeat-like)|interpro:IPR019559|interpro:IPR036317|interpro:IPR036388|interpro:IPR036390|mint:Q13617|rcsb pdb:4WQO|rcsb pdb:5N4W|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|rcsb pdb:6R7N|reactome:R-HSA-1234176|reactome:R-HSA-8951664|ensembl:ENSG00000108094(gene)|reactome:R-HSA-983168|reactome:R-HSA-9010553 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2020/10/21 rogid:hyuYyAujJCJtbfS2tJ+UgH7jWP89606 rogid:ffttNV1NYH8UnmbHxf+ygcIG1wE9606 intact-crc:B58AF288F9C81A77|rigid:/fWQJTQK1fD0fpKu4c/6K/d+bMo false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q7L5N1 uniprotkb:Q15369 intact:EBI-486838|uniprotkb:O15387|uniprotkb:A4D2A3|ensembl:ENSP00000304102 intact:EBI-301231|uniprotkb:Q567Q6|ensembl:ENSP00000284811|ensembl:ENSP00000428074|ensembl:ENSP00000428171|ensembl:ENSP00000428334|ensembl:ENSP00000429596|ensembl:ENSP00000429906|ensembl:ENSP00000478121|uniprotkb:E5RGD9 psi-mi:csn6_human(display_long)|uniprotkb:COPS6(gene name)|psi-mi:COPS6(display_short)|uniprotkb:CSN6(gene name synonym)|uniprotkb:HVIP(gene name synonym)|uniprotkb:JAB1-containing signalosome subunit 6(gene name synonym)|uniprotkb:Vpr-interacting protein(gene name synonym)|uniprotkb:MOV34 homolog(gene name synonym) psi-mi:eloc_human(display_long)|uniprotkb:ELOC(gene name)|psi-mi:ELOC(display_short)|uniprotkb:Elongin 15 kDa subunit(gene name synonym)|uniprotkb:RNA polymerase II transcription factor SIII subunit C(gene name synonym)|uniprotkb:SIII p15(gene name synonym)|uniprotkb:TCEB1(gene name synonym)|uniprotkb:Transcription elongation factor B polypeptide 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510262|imex:IM-12079-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006824.2|ensembl:ENSG00000168090(gene)|ensembl:ENST00000303904(transcript)|go:"GO:0000338"(protein deneddylation)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070122"(isopeptidase activity)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR033859|interpro:IPR024969|interpro:IPR037518|mint:Q7L5N1|rcsb pdb:4D10|rcsb pdb:4D18|rcsb pdb:4QFT|rcsb pdb:4R14|rcsb pdb:4WSN|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|reactome:R-HSA-5696394|reactome:R-HSA-6781823|reactome:R-HSA-8856825|reactome:R-HSA-8951664|dip:DIP-32655N refseq:NP_005639.1|refseq:NP_001191786.1|refseq:NP_001191787.1|refseq:NP_001191788.1|refseq:NP_001191789.1|refseq:NP_001191790.1|refseq:NP_001191791.1|refseq:NP_001191792.1|refseq:NP_001191793.1|ensembl:ENSG00000154582(gene)|ensembl:ENST00000284811(transcript)|ensembl:ENST00000518127(transcript)|ensembl:ENST00000519487(transcript)|ensembl:ENST00000520242(transcript)|ensembl:ENST00000522337(transcript)|ensembl:ENST00000523815(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0031462"(Cul2-RING ubiquitin ligase complex)|go:"GO:0070449"(elongin complex)|interpro:IPR001232(SKP1 component)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR016073(SKP1 component, POZ)|interpro:IPR039948|mint:Q15369|rcsb pdb:1LM8|rcsb pdb:1LQB|rcsb pdb:1VCB|rcsb pdb:2C9W|rcsb pdb:2IZV|rcsb pdb:2MA9|rcsb pdb:3DCG|rcsb pdb:3ZKJ|rcsb pdb:3ZNG|rcsb pdb:3ZRC|rcsb pdb:3ZRF|rcsb pdb:3ZTC|rcsb pdb:3ZTD|rcsb pdb:3ZUN|rcsb pdb:4AJY|rcsb pdb:4AWJ|ensembl:ENST00000622804(transcript)|rcsb pdb:4B95|rcsb pdb:4B9K|rcsb pdb:4BKS|rcsb pdb:4BKT|rcsb pdb:4N9F|rcsb pdb:4W9C|rcsb pdb:4W9D|rcsb pdb:4W9E|rcsb pdb:4W9F|rcsb pdb:4W9G|rcsb pdb:4W9H|rcsb pdb:4W9I|rcsb pdb:4W9J|rcsb pdb:4W9K|rcsb pdb:4W9L|rcsb pdb:4WQO|rcsb pdb:5BO4|rcsb pdb:5LLI|rcsb pdb:5N4W|rcsb pdb:5NVV|rcsb pdb:5NVW|rcsb pdb:5NVX|rcsb pdb:5NVY|rcsb pdb:5NVZ|rcsb pdb:5NW0|rcsb pdb:5NW1|rcsb pdb:5NW2|rcsb pdb:5T35|rcsb pdb:6BVB|rcsb pdb:6C5X|rcsb pdb:6FMI|rcsb pdb:6FMJ|rcsb pdb:6FMK|rcsb pdb:6GFX|rcsb pdb:6GFZ|rcsb pdb:6GMN|rcsb pdb:6GMQ|rcsb pdb:6GMR|rcsb pdb:6GMX|rcsb pdb:6HAX|rcsb pdb:6GFY|rcsb pdb:6HAY|rcsb pdb:6HR2|rcsb pdb:6I4X|rcsb pdb:6I5J|rcsb pdb:6I5N|rcsb pdb:6I7R|rcsb pdb:6P59|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7N|rcsb pdb:6SIS|rcsb pdb:6V9H|rcsb pdb:6ZHC|rcsb pdb:7KHH|reactome:R-HSA-112382|reactome:R-HSA-1234176|reactome:R-HSA-167152|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-180585|reactome:R-HSA-674695|reactome:R-HSA-6796648|reactome:R-HSA-75955|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9705462|reactome:R-HSA-983168|reactome:R-HSA-167200|refseq:XP_011515882.1|refseq:XP_011515883.1|dip:DIP-29571N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2020/10/21 rogid:hyuYyAujJCJtbfS2tJ+UgH7jWP89606 rogid:Ngvkh3YoddZoutF3Vgwdi2b6xz49606 intact-crc:B58AF288F9C81A77|rigid:/fWQJTQK1fD0fpKu4c/6K/d+bMo false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q7L5N1 uniprotkb:Q53GT1 intact:EBI-486838|uniprotkb:O15387|uniprotkb:A4D2A3|ensembl:ENSP00000304102 intact:EBI-1996072|uniprotkb:D3DX30|uniprotkb:Q96B68|uniprotkb:Q96KC6|uniprotkb:A8MTV3|uniprotkb:A8K3Q4|ensembl:ENSP00000331682|uniprotkb:B7Z2G1 psi-mi:csn6_human(display_long)|uniprotkb:COPS6(gene name)|psi-mi:COPS6(display_short)|uniprotkb:CSN6(gene name synonym)|uniprotkb:HVIP(gene name synonym)|uniprotkb:JAB1-containing signalosome subunit 6(gene name synonym)|uniprotkb:Vpr-interacting protein(gene name synonym)|uniprotkb:MOV34 homolog(gene name synonym) psi-mi:klh22_human(display_long)|uniprotkb:KLHL22(gene name)|psi-mi:KLHL22(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510262|imex:IM-12079-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006824.2|ensembl:ENSG00000168090(gene)|ensembl:ENST00000303904(transcript)|go:"GO:0000338"(protein deneddylation)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070122"(isopeptidase activity)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR033859|interpro:IPR024969|interpro:IPR037518|mint:Q7L5N1|rcsb pdb:4D10|rcsb pdb:4D18|rcsb pdb:4QFT|rcsb pdb:4R14|rcsb pdb:4WSN|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|reactome:R-HSA-5696394|reactome:R-HSA-6781823|reactome:R-HSA-8856825|reactome:R-HSA-8951664|dip:DIP-32655N refseq:NP_116164.2|refseq:XP_016884510.1|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005813"(centrosome)|go:"GO:0005827"(polar microtubule)|go:"GO:0005829"(cytosol)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045171"(intercellular bridge)|go:"GO:0051301"(cell division)|go:"GO:0071233"(cellular response to leucine)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0072686"(mitotic spindle)|go:"GO:1904263"(positive regulation of TORC1 signaling)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR011705(BTB/Kelch-associated)|interpro:IPR015915(Kelch-type beta propeller)|interpro:IPR017096(Kelch-like protein, gigaxonin)|interpro:IPR030575|mint:Q53GT1|reactome:R-HSA-8951664|reactome:R-HSA-983168|ensembl:ENSG00000099910(gene)|ensembl:ENST00000328879(transcript) psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2020/10/21 rogid:hyuYyAujJCJtbfS2tJ+UgH7jWP89606 rogid:EC3vXSWYpde+ZCa6lm86DF+sfM89606 intact-crc:B58AF288F9C81A77|rigid:/fWQJTQK1fD0fpKu4c/6K/d+bMo false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q7L5N1 uniprotkb:Q9UK73 intact:EBI-486838|uniprotkb:O15387|uniprotkb:A4D2A3|ensembl:ENSP00000304102 intact:EBI-310482|uniprotkb:O43146|ensembl:ENSP00000307298 psi-mi:csn6_human(display_long)|uniprotkb:COPS6(gene name)|psi-mi:COPS6(display_short)|uniprotkb:CSN6(gene name synonym)|uniprotkb:HVIP(gene name synonym)|uniprotkb:JAB1-containing signalosome subunit 6(gene name synonym)|uniprotkb:Vpr-interacting protein(gene name synonym)|uniprotkb:MOV34 homolog(gene name synonym) psi-mi:fem1b_human(display_long)|uniprotkb:FEM1B(gene name)|psi-mi:FEM1B(display_short)|uniprotkb:KIAA0396(gene name synonym)|uniprotkb:F1AA(gene name synonym)|uniprotkb:FEM1-beta(gene name synonym)|uniprotkb:Fem-1-like death receptor-binding protein alpha(gene name synonym)|uniprotkb:Fem-1-like in apoptotic pathway protein alpha(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510262|imex:IM-12079-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006824.2|ensembl:ENSG00000168090(gene)|ensembl:ENST00000303904(transcript)|go:"GO:0000338"(protein deneddylation)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070122"(isopeptidase activity)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR033859|interpro:IPR024969|interpro:IPR037518|mint:Q7L5N1|rcsb pdb:4D10|rcsb pdb:4D18|rcsb pdb:4QFT|rcsb pdb:4R14|rcsb pdb:4WSN|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|reactome:R-HSA-5696394|reactome:R-HSA-6781823|reactome:R-HSA-8856825|reactome:R-HSA-8951664|dip:DIP-32655N refseq:NP_056137.1|ensembl:ENSG00000169018(gene)|ensembl:ENST00000306917(transcript)|go:"GO:0005123"(death receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0031462"(Cul2-RING ubiquitin ligase complex)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0051438"(regulation of ubiquitin-protein transferase activity)|go:"GO:0060442"(branching involved in prostate gland morphogenesis)|go:"GO:0060743"(epithelial cell maturation involved in prostate gland development)|go:"GO:0140627"(ubiquitin-dependent protein catabolic process via the C-end degron rule pathway)|go:"GO:1902041"(regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR036770|rcsb pdb:6LBF|rcsb pdb:7CNG|rcsb pdb:7EL6|reactome:R-HSA-8951664|go:"GO:2000001"(regulation of DNA damage checkpoint)|dip:DIP-31663N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2020/10/21 rogid:hyuYyAujJCJtbfS2tJ+UgH7jWP89606 rogid:ODOxw01NrJ8fUJv2XopsdTYtAr49606 intact-crc:B58AF288F9C81A77|rigid:/fWQJTQK1fD0fpKu4c/6K/d+bMo false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q7L5N1 uniprotkb:Q92905 intact:EBI-486838|uniprotkb:O15387|uniprotkb:A4D2A3|ensembl:ENSP00000304102 intact:EBI-594661|uniprotkb:O15386|uniprotkb:Q6AW95|uniprotkb:Q86WQ4|uniprotkb:Q9BQ17|ensembl:ENSP00000350512 psi-mi:csn6_human(display_long)|uniprotkb:COPS6(gene name)|psi-mi:COPS6(display_short)|uniprotkb:CSN6(gene name synonym)|uniprotkb:HVIP(gene name synonym)|uniprotkb:JAB1-containing signalosome subunit 6(gene name synonym)|uniprotkb:Vpr-interacting protein(gene name synonym)|uniprotkb:MOV34 homolog(gene name synonym) psi-mi:csn5_human(display_long)|uniprotkb:Jun activation domain-binding protein 1(gene name synonym)|uniprotkb:COPS5(gene name)|psi-mi:COPS5(display_short)|uniprotkb:CSN5(gene name synonym)|uniprotkb:JAB1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510262|imex:IM-12079-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006824.2|ensembl:ENSG00000168090(gene)|ensembl:ENST00000303904(transcript)|go:"GO:0000338"(protein deneddylation)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070122"(isopeptidase activity)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR033859|interpro:IPR024969|interpro:IPR037518|mint:Q7L5N1|rcsb pdb:4D10|rcsb pdb:4D18|rcsb pdb:4QFT|rcsb pdb:4R14|rcsb pdb:4WSN|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|reactome:R-HSA-5696394|reactome:R-HSA-6781823|reactome:R-HSA-8856825|reactome:R-HSA-8951664|dip:DIP-32655N refseq:NP_006828.2|dip:DIP-34546N|ensembl:ENSG00000121022(gene)|ensembl:ENST00000357849(transcript)|go:"GO:0000338"(protein deneddylation)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006412"(translation)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019784"(NEDD8-specific protease activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0035718"(macrophage migration inhibitory factor binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070122"(isopeptidase activity)|go:"GO:1903894"(regulation of IRE1-mediated unfolded protein response)|go:"GO:1990182"(exosomal secretion)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR037518|interpro:IPR037740|interpro:IPR040961|mint:Q92905|rcsb pdb:4D10|rcsb pdb:4D18|rcsb pdb:4F7O|rcsb pdb:4WSN|rcsb pdb:5JOG|rcsb pdb:5JOH|rcsb pdb:5M5Q|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|reactome:R-HSA-5696394|reactome:R-HSA-6781823|reactome:R-HSA-8856825|reactome:R-HSA-8951664 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2020/10/21 rogid:hyuYyAujJCJtbfS2tJ+UgH7jWP89606 rogid:GMgH8dW3KWILX6Mr/+XrgAV3xY49606 intact-crc:B58AF288F9C81A77|rigid:/fWQJTQK1fD0fpKu4c/6K/d+bMo false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q7L5N1 uniprotkb:B4DN30 intact:EBI-486838|uniprotkb:O15387|uniprotkb:A4D2A3|ensembl:ENSP00000304102 intact:EBI-2510114 psi-mi:csn6_human(display_long)|uniprotkb:COPS6(gene name)|psi-mi:COPS6(display_short)|uniprotkb:CSN6(gene name synonym)|uniprotkb:HVIP(gene name synonym)|uniprotkb:JAB1-containing signalosome subunit 6(gene name synonym)|uniprotkb:Vpr-interacting protein(gene name synonym)|uniprotkb:MOV34 homolog(gene name synonym) psi-mi:b4dn30_human(display_long) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510262|imex:IM-12079-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006824.2|ensembl:ENSG00000168090(gene)|ensembl:ENST00000303904(transcript)|go:"GO:0000338"(protein deneddylation)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070122"(isopeptidase activity)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR033859|interpro:IPR024969|interpro:IPR037518|mint:Q7L5N1|rcsb pdb:4D10|rcsb pdb:4D18|rcsb pdb:4QFT|rcsb pdb:4R14|rcsb pdb:4WSN|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|reactome:R-HSA-5696394|reactome:R-HSA-6781823|reactome:R-HSA-8856825|reactome:R-HSA-8951664|dip:DIP-32655N interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR001680(WD40 repeat)|refseq:NP_001156981.1|interpro:IPR036322 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2020/10/21 rogid:hyuYyAujJCJtbfS2tJ+UgH7jWP89606 rogid:Mk9d67PQ07hQYLpZ+jTq4hfKRWk9606 intact-crc:B58AF288F9C81A77|rigid:/fWQJTQK1fD0fpKu4c/6K/d+bMo false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q7L5N1 uniprotkb:Q8TBC3 intact:EBI-486838|uniprotkb:O15387|uniprotkb:A4D2A3|ensembl:ENSP00000304102 intact:EBI-724292|uniprotkb:Q8N2I6|uniprotkb:Q96IB8|uniprotkb:Q8WY93|intact:EBI-28987662|ensembl:ENSP00000291842 psi-mi:csn6_human(display_long)|uniprotkb:COPS6(gene name)|psi-mi:COPS6(display_short)|uniprotkb:CSN6(gene name synonym)|uniprotkb:HVIP(gene name synonym)|uniprotkb:JAB1-containing signalosome subunit 6(gene name synonym)|uniprotkb:Vpr-interacting protein(gene name synonym)|uniprotkb:MOV34 homolog(gene name synonym) psi-mi:shkb1_human(display_long)|uniprotkb:SHKBP1(gene name)|psi-mi:SHKBP1(display_short)|uniprotkb:SB1(gene name synonym)|uniprotkb:SETA-binding protein 1(gene name synonym)|uniprotkb:PP203(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510262|imex:IM-12079-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006824.2|ensembl:ENSG00000168090(gene)|ensembl:ENST00000303904(transcript)|go:"GO:0000338"(protein deneddylation)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070122"(isopeptidase activity)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR033859|interpro:IPR024969|interpro:IPR037518|mint:Q7L5N1|rcsb pdb:4D10|rcsb pdb:4D18|rcsb pdb:4QFT|rcsb pdb:4R14|rcsb pdb:4WSN|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|reactome:R-HSA-5696394|reactome:R-HSA-6781823|reactome:R-HSA-8856825|reactome:R-HSA-8951664|dip:DIP-32655N refseq:NP_612401.2|interpro:IPR001680(WD40 repeat)|interpro:IPR003131(Potassium channel, voltage dependent, Kv, tetramerisation)|ensembl:ENSG00000160410(gene)|ensembl:ENST00000291842(transcript)|go:"GO:0005764"(lysosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0051260"(protein homooligomerization)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR036322|rcsb pdb:4CRH|reactome:R-HSA-9013148|ensembl:ENSP00000291842 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2020/10/21 rogid:hyuYyAujJCJtbfS2tJ+UgH7jWP89606 rogid:2cIBkgod4mRxgPSslubgbqyJtFk9606 intact-crc:B58AF288F9C81A77|rigid:/fWQJTQK1fD0fpKu4c/6K/d+bMo false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q7L5N1 uniprotkb:Q9H496 intact:EBI-486838|uniprotkb:O15387|uniprotkb:A4D2A3|ensembl:ENSP00000304102 intact:EBI-2510146|ensembl:ENSP00000485355|uniprotkb:Q05BU2 psi-mi:csn6_human(display_long)|uniprotkb:COPS6(gene name)|psi-mi:COPS6(display_short)|uniprotkb:CSN6(gene name synonym)|uniprotkb:HVIP(gene name synonym)|uniprotkb:JAB1-containing signalosome subunit 6(gene name synonym)|uniprotkb:Vpr-interacting protein(gene name synonym)|uniprotkb:MOV34 homolog(gene name synonym) psi-mi:ifg15_human(display_long)|uniprotkb:IFRG15(gene name synonym)|uniprotkb:TOR1AIP2(gene name)|psi-mi:TOR1AIP2(display_short)|uniprotkb:15 kDa interferon-responsive protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510262|imex:IM-12079-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006824.2|ensembl:ENSG00000168090(gene)|ensembl:ENST00000303904(transcript)|go:"GO:0000338"(protein deneddylation)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070122"(isopeptidase activity)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR033859|interpro:IPR024969|interpro:IPR037518|mint:Q7L5N1|rcsb pdb:4D10|rcsb pdb:4D18|rcsb pdb:4QFT|rcsb pdb:4R14|rcsb pdb:4WSN|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|reactome:R-HSA-5696394|reactome:R-HSA-6781823|reactome:R-HSA-8856825|reactome:R-HSA-8951664|dip:DIP-32655N ensembl:ENSG00000169905(gene)|ensembl:ENST00000482587(transcript)|refseq:NP_071742.1|refseq:XP_016855966.1|refseq:XP_016855967.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2020/10/21 rogid:hyuYyAujJCJtbfS2tJ+UgH7jWP89606 rogid:JTZAx1BSMfctWtiQyePC82lYQnM9606 intact-crc:B58AF288F9C81A77|rigid:/fWQJTQK1fD0fpKu4c/6K/d+bMo false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q7L5N1 uniprotkb:Q8TEB1 intact:EBI-486838|uniprotkb:O15387|uniprotkb:A4D2A3|ensembl:ENSP00000304102 intact:EBI-2213388|uniprotkb:Q5D039|uniprotkb:Q86U00|uniprotkb:Q86U39|uniprotkb:Q8NDN2|uniprotkb:Q9H2J0|uniprotkb:Q9H3A3|uniprotkb:Q9H5C9|uniprotkb:D3DS56|uniprotkb:B3KQ83|ensembl:ENSP00000415556|ensembl:ENSP00000452898|ensembl:ENSP00000494282|ensembl:ENSP00000495416 psi-mi:csn6_human(display_long)|uniprotkb:COPS6(gene name)|psi-mi:COPS6(display_short)|uniprotkb:CSN6(gene name synonym)|uniprotkb:HVIP(gene name synonym)|uniprotkb:JAB1-containing signalosome subunit 6(gene name synonym)|uniprotkb:Vpr-interacting protein(gene name synonym)|uniprotkb:MOV34 homolog(gene name synonym) psi-mi:dca11_human(display_long)|uniprotkb:DCAF11(gene name)|psi-mi:DCAF11(display_short)|uniprotkb:GL014(orf name)|uniprotkb:PRO2389(orf name)|uniprotkb:WDR23(gene name synonym)|uniprotkb:WD repeat-containing protein 23(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510262|imex:IM-12079-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006824.2|ensembl:ENSG00000168090(gene)|ensembl:ENST00000303904(transcript)|go:"GO:0000338"(protein deneddylation)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070122"(isopeptidase activity)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR033859|interpro:IPR024969|interpro:IPR037518|mint:Q7L5N1|rcsb pdb:4D10|rcsb pdb:4D18|rcsb pdb:4QFT|rcsb pdb:4R14|rcsb pdb:4WSN|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|reactome:R-HSA-5696394|reactome:R-HSA-6781823|reactome:R-HSA-8856825|reactome:R-HSA-8951664|dip:DIP-32655N refseq:NP_001156956.1|refseq:NP_079506.3|refseq:NP_852002.1|ensembl:ENSG00000100897(gene)|ensembl:ENSG00000284796(gene)|ensembl:ENST00000446197(transcript)|ensembl:ENST00000559115(transcript)|ensembl:ENST00000642239(transcript)|ensembl:ENST00000646568(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0080008"(Cul4-RING E3 ubiquitin ligase complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR017399(WD repeat protein 23)|interpro:IPR020472|interpro:IPR036322|mint:Q8TEB1|reactome:R-HSA-8951664 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2020/10/21 rogid:hyuYyAujJCJtbfS2tJ+UgH7jWP89606 rogid:iQQ4lP7NSE1MIcskh1XBjj9CC0s9606 intact-crc:B58AF288F9C81A77|rigid:/fWQJTQK1fD0fpKu4c/6K/d+bMo false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q7L5N1 uniprotkb:Q13309 intact:EBI-486838|uniprotkb:O15387|uniprotkb:A4D2A3|ensembl:ENSP00000304102 intact:EBI-456291|uniprotkb:Q8TDZ0|uniprotkb:Q8TDZ1|uniprotkb:Q9BV69|ensembl:ENSP00000274255|uniprotkb:A8K5E0|uniprotkb:B4DJT4 psi-mi:csn6_human(display_long)|uniprotkb:COPS6(gene name)|psi-mi:COPS6(display_short)|uniprotkb:CSN6(gene name synonym)|uniprotkb:HVIP(gene name synonym)|uniprotkb:JAB1-containing signalosome subunit 6(gene name synonym)|uniprotkb:Vpr-interacting protein(gene name synonym)|uniprotkb:MOV34 homolog(gene name synonym) psi-mi:skp2_human(display_long)|uniprotkb:F-box protein Skp2(gene name synonym)|uniprotkb:Cyclin-A/CDK2-associated protein p45(gene name synonym)|uniprotkb:p45skp2(gene name synonym)|uniprotkb:F-box/LRR-repeat protein 1(gene name synonym)|uniprotkb:SKP2(gene name)|psi-mi:SKP2(display_short)|uniprotkb:FBXL1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510262|imex:IM-12079-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006824.2|ensembl:ENSG00000168090(gene)|ensembl:ENST00000303904(transcript)|go:"GO:0000338"(protein deneddylation)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070122"(isopeptidase activity)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR033859|interpro:IPR024969|interpro:IPR037518|mint:Q7L5N1|rcsb pdb:4D10|rcsb pdb:4D18|rcsb pdb:4QFT|rcsb pdb:4R14|rcsb pdb:4WSN|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|reactome:R-HSA-5696394|reactome:R-HSA-6781823|reactome:R-HSA-8856825|reactome:R-HSA-8951664|dip:DIP-32655N ensembl:ENSG00000145604(gene)|ensembl:ENST00000274255(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0033148"(positive regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045087"(innate immune response)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0051607"(defense response to virus)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0071460"(cellular response to cell-matrix adhesion)|go:"GO:1902916"(positive regulation of protein polyubiquitination)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR006553(Leucine-rich repeat, cysteine-containing subtype)|rcsb pdb:2ASS|rcsb pdb:2AST|interpro:IPR032675|rcsb pdb:7B5L|interpro:IPR036047|mint:Q13309|rcsb pdb:1FQV|rcsb pdb:7B5M|rcsb pdb:1FS1|rcsb pdb:1FS2|rcsb pdb:1LDK|refseq:NP_005974.2|refseq:NP_116026.1|refseq:NP_001230049.1|dip:DIP-17011N|rcsb pdb:7B5R|reactome:R-HSA-174178|reactome:R-HSA-187577|reactome:R-HSA-5689880|reactome:R-HSA-68949|reactome:R-HSA-69231|reactome:R-HSA-8939902|reactome:R-HSA-8951664|reactome:R-HSA-9687136|reactome:R-HSA-9708530|reactome:R-HSA-983168 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2020/10/21 rogid:hyuYyAujJCJtbfS2tJ+UgH7jWP89606 rogid:VABxcX3qu0Yr6eRNYINqvAPhPMc9606 intact-crc:B58AF288F9C81A77|rigid:/fWQJTQK1fD0fpKu4c/6K/d+bMo false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q7L5N1 uniprotkb:Q9P2K6 intact:EBI-486838|uniprotkb:O15387|uniprotkb:A4D2A3|ensembl:ENSP00000304102 intact:EBI-739890|uniprotkb:Q2VPK1|uniprotkb:Q8N334|ensembl:ENSP00000370671 psi-mi:csn6_human(display_long)|uniprotkb:COPS6(gene name)|psi-mi:COPS6(display_short)|uniprotkb:CSN6(gene name synonym)|uniprotkb:HVIP(gene name synonym)|uniprotkb:JAB1-containing signalosome subunit 6(gene name synonym)|uniprotkb:Vpr-interacting protein(gene name synonym)|uniprotkb:MOV34 homolog(gene name synonym) psi-mi:klh42_human(display_long)|uniprotkb:KLHL42(gene name)|psi-mi:KLHL42(display_short)|uniprotkb:Cullin-3-binding protein 9(gene name synonym)|uniprotkb:KIAA1340(gene name synonym)|uniprotkb:KLHDC5(gene name synonym)|uniprotkb:Kelch domain-containing protein 5(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510262|imex:IM-12079-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006824.2|ensembl:ENSG00000168090(gene)|ensembl:ENST00000303904(transcript)|go:"GO:0000338"(protein deneddylation)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070122"(isopeptidase activity)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR033859|interpro:IPR024969|interpro:IPR037518|mint:Q7L5N1|rcsb pdb:4D10|rcsb pdb:4D18|rcsb pdb:4QFT|rcsb pdb:4R14|rcsb pdb:4WSN|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|reactome:R-HSA-5696394|reactome:R-HSA-6781823|reactome:R-HSA-8856825|reactome:R-HSA-8951664|dip:DIP-32655N refseq:NP_065833.1|ensembl:ENSG00000087448(gene)|ensembl:ENST00000381271(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0007049"(cell cycle)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0051301"(cell division)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR011705(BTB/Kelch-associated)|interpro:IPR015915(Kelch-type beta propeller)|interpro:IPR044727|reactome:R-HSA-8951664|reactome:R-HSA-983168 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2020/10/21 rogid:hyuYyAujJCJtbfS2tJ+UgH7jWP89606 rogid:yJggodiT351m3/HVgDumWQXnp949606 intact-crc:B58AF288F9C81A77|rigid:/fWQJTQK1fD0fpKu4c/6K/d+bMo false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q7L5N1 uniprotkb:Q13216 intact:EBI-486838|uniprotkb:O15387|uniprotkb:A4D2A3|ensembl:ENSP00000304102 intact:EBI-295260|uniprotkb:Q6FHX5|uniprotkb:Q96GB9|uniprotkb:B2RB64|intact:EBI-28983947|ensembl:ENSP00000501614 psi-mi:csn6_human(display_long)|uniprotkb:COPS6(gene name)|psi-mi:COPS6(display_short)|uniprotkb:CSN6(gene name synonym)|uniprotkb:HVIP(gene name synonym)|uniprotkb:JAB1-containing signalosome subunit 6(gene name synonym)|uniprotkb:Vpr-interacting protein(gene name synonym)|uniprotkb:MOV34 homolog(gene name synonym) psi-mi:ercc8_human(display_long)|uniprotkb:ERCC8(gene name)|psi-mi:ERCC8(display_short)|uniprotkb:CSA(gene name synonym)|uniprotkb:CKN1(gene name synonym)|uniprotkb:Cockayne syndrome WD repeat protein CSA(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510262|imex:IM-12079-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006824.2|ensembl:ENSG00000168090(gene)|ensembl:ENST00000303904(transcript)|go:"GO:0000338"(protein deneddylation)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070122"(isopeptidase activity)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR033859|interpro:IPR024969|interpro:IPR037518|mint:Q7L5N1|rcsb pdb:4D10|rcsb pdb:4D18|rcsb pdb:4QFT|rcsb pdb:4R14|rcsb pdb:4WSN|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|reactome:R-HSA-5696394|reactome:R-HSA-6781823|reactome:R-HSA-8856825|reactome:R-HSA-8951664|dip:DIP-32655N refseq:NP_001007235.1|refseq:NP_000073.1|ensembl:ENST00000647486|ensembl:ENSP00000494466|ensembl:ENST00000675229|ensembl:ENSP00000502154|ensembl:ENSP00000501614|dip:DIP-291N|ensembl:ENSG00000049167(gene)|ensembl:ENST00000676185(transcript)|go:"GO:0000012"(single strand break repair)|go:"GO:0000109"(nucleotide-excision repair complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006283"(transcription-coupled nucleotide-excision repair)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0009411"(response to UV)|go:"GO:0016363"(nuclear matrix)|go:"GO:0031464"(Cul4A-RING E3 ubiquitin ligase complex)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0080008"(Cul4-RING E3 ubiquitin ligase complex)|go:"GO:0097680"(double-strand break repair via classical nonhomologous end joining)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|interpro:IPR042238|rcsb pdb:4A11|rcsb pdb:6FCV|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-8951664 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2020/10/21 rogid:hyuYyAujJCJtbfS2tJ+UgH7jWP89606 rogid:rAvPc8OiKusCMRi//0rJWsMu+dg9606 intact-crc:B58AF288F9C81A77|rigid:/fWQJTQK1fD0fpKu4c/6K/d+bMo false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q7L5N1 uniprotkb:Q9NZJ0 intact:EBI-486838|uniprotkb:O15387|uniprotkb:A4D2A3|ensembl:ENSP00000304102 intact:EBI-1176075|uniprotkb:Q5VT77|uniprotkb:Q96SN0|uniprotkb:Q9NW03|uniprotkb:Q9NW34|uniprotkb:Q9NWM5|uniprotkb:A8K8H8|uniprotkb:D3DT98|intact:EBI-2559087|ensembl:ENSP00000355958 psi-mi:csn6_human(display_long)|uniprotkb:COPS6(gene name)|psi-mi:COPS6(display_short)|uniprotkb:CSN6(gene name synonym)|uniprotkb:HVIP(gene name synonym)|uniprotkb:JAB1-containing signalosome subunit 6(gene name synonym)|uniprotkb:Vpr-interacting protein(gene name synonym)|uniprotkb:MOV34 homolog(gene name synonym) psi-mi:dtl_human(display_long)|uniprotkb:"Lethal(2) denticleless protein homolog"(gene name synonym)|uniprotkb:DDB1- and CUL4-associated factor 2(gene name synonym)|uniprotkb:Retinoic acid-regulated nuclear matrix-associated protein(gene name synonym)|uniprotkb:DTL(gene name)|psi-mi:DTL(display_short)|uniprotkb:CDT2(gene name synonym)|uniprotkb:CDW1(gene name synonym)|uniprotkb:DCAF2(gene name synonym)|uniprotkb:L2DTL(gene name synonym)|uniprotkb:RAMP(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510262|imex:IM-12079-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006824.2|ensembl:ENSG00000168090(gene)|ensembl:ENST00000303904(transcript)|go:"GO:0000338"(protein deneddylation)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070122"(isopeptidase activity)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR033859|interpro:IPR024969|interpro:IPR037518|mint:Q7L5N1|rcsb pdb:4D10|rcsb pdb:4D18|rcsb pdb:4QFT|rcsb pdb:4R14|rcsb pdb:4WSN|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|reactome:R-HSA-5696394|reactome:R-HSA-6781823|reactome:R-HSA-8856825|reactome:R-HSA-8951664|dip:DIP-32655N refseq:NP_001273158.1|refseq:NP_057532.3|ensembl:ENSG00000143476(gene)|ensembl:ENST00000366991(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0009411"(response to UV)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0019985"(translesion synthesis)|go:"GO:0031464"(Cul4A-RING E3 ubiquitin ligase complex)|go:"GO:0031465"(Cul4B-RING E3 ubiquitin ligase complex)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0048511"(rhythmic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0080008"(Cul4-RING E3 ubiquitin ligase complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|rcsb pdb:6QC0|reactome:R-HSA-110314|reactome:R-HSA-8951664|go:"GO:0031965"(nuclear membrane) psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2020/10/21 rogid:hyuYyAujJCJtbfS2tJ+UgH7jWP89606 rogid:pp9gRfayDQZsdioTjmCAbPPzlJI9606 intact-crc:B58AF288F9C81A77|rigid:/fWQJTQK1fD0fpKu4c/6K/d+bMo false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q7L5N1 uniprotkb:Q86XK2 intact:EBI-486838|uniprotkb:O15387|uniprotkb:A4D2A3|ensembl:ENSP00000304102 intact:EBI-1047804|uniprotkb:Q9H9L1|uniprotkb:Q9NR14|uniprotkb:Q9UFK1|uniprotkb:Q52ZP1|uniprotkb:Q53EP7|uniprotkb:Q8IXG3|uniprotkb:Q96E90|uniprotkb:Q9H6V8|uniprotkb:Q9UHI1|uniprotkb:Q9UKC2|uniprotkb:Q53RT5|uniprotkb:A1L491|ensembl:ENSP00000384823 psi-mi:csn6_human(display_long)|uniprotkb:COPS6(gene name)|psi-mi:COPS6(display_short)|uniprotkb:CSN6(gene name synonym)|uniprotkb:HVIP(gene name synonym)|uniprotkb:JAB1-containing signalosome subunit 6(gene name synonym)|uniprotkb:Vpr-interacting protein(gene name synonym)|uniprotkb:MOV34 homolog(gene name synonym) psi-mi:fbx11_human(display_long)|uniprotkb:Vitiligo-associated protein 1(gene name synonym)|uniprotkb:FBXO11(gene name)|psi-mi:FBXO11(display_short)|uniprotkb:FBX11(gene name synonym)|uniprotkb:VIT1(gene name synonym)|uniprotkb:PRMT9(gene name synonym)|uniprotkb:Protein arginine N-methyltransferase 9(gene name synonym)|uniprotkb:UG063H01(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510262|imex:IM-12079-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006824.2|ensembl:ENSG00000168090(gene)|ensembl:ENST00000303904(transcript)|go:"GO:0000338"(protein deneddylation)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070122"(isopeptidase activity)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR033859|interpro:IPR024969|interpro:IPR037518|mint:Q7L5N1|rcsb pdb:4D10|rcsb pdb:4D18|rcsb pdb:4QFT|rcsb pdb:4R14|rcsb pdb:4WSN|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|reactome:R-HSA-5696394|reactome:R-HSA-6781823|reactome:R-HSA-8856825|reactome:R-HSA-8951664|dip:DIP-32655N refseq:NP_001177203.1|refseq:XP_016860506.1|refseq:NP_079409.3|refseq:XP_005264629.1|dip:DIP-35680N|ensembl:ENSG00000138081(gene)|ensembl:ENST00000403359(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016274"(protein-arginine N-methyltransferase activity)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0042981"(regulation of apoptotic process)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR003126(Zinc finger, N-recognin)|interpro:IPR006626(Parallel beta-helix repeat)|interpro:IPR006633(Carbohydrate-binding and sugar hydrolysis)|interpro:IPR007742(Periplasmic copper-binding)|interpro:IPR011050(Pectin lyase fold/virulence factor)|interpro:IPR012334(Pectin lyase fold)|interpro:IPR022441|interpro:IPR029799|interpro:IPR036047|interpro:IPR039448|rcsb pdb:5VMD|reactome:R-HSA-8951664|reactome:R-HSA-983168 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2020/10/21 rogid:hyuYyAujJCJtbfS2tJ+UgH7jWP89606 rogid:7tSKElIYe8osUxG4NtKI0lWkLak9606 intact-crc:B58AF288F9C81A77|rigid:/fWQJTQK1fD0fpKu4c/6K/d+bMo false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q7L5N1 uniprotkb:Q92466 intact:EBI-486838|uniprotkb:O15387|uniprotkb:A4D2A3|ensembl:ENSP00000304102 intact:EBI-1176171|uniprotkb:Q76E54|uniprotkb:Q76E55|uniprotkb:Q76E56|uniprotkb:Q76E57|uniprotkb:B2R875|ensembl:ENSP00000256996 psi-mi:csn6_human(display_long)|uniprotkb:COPS6(gene name)|psi-mi:COPS6(display_short)|uniprotkb:CSN6(gene name synonym)|uniprotkb:HVIP(gene name synonym)|uniprotkb:JAB1-containing signalosome subunit 6(gene name synonym)|uniprotkb:Vpr-interacting protein(gene name synonym)|uniprotkb:MOV34 homolog(gene name synonym) psi-mi:ddb2_human(display_long)|uniprotkb:Damage-specific DNA-binding protein 2(gene name synonym)|uniprotkb:DDB p48 subunit(gene name synonym)|uniprotkb:UV-damaged DNA-binding protein 2(gene name synonym)|uniprotkb:DDB2(gene name)|psi-mi:DDB2(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510262|imex:IM-12079-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006824.2|ensembl:ENSG00000168090(gene)|ensembl:ENST00000303904(transcript)|go:"GO:0000338"(protein deneddylation)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070122"(isopeptidase activity)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR033859|interpro:IPR024969|interpro:IPR037518|mint:Q7L5N1|rcsb pdb:4D10|rcsb pdb:4D18|rcsb pdb:4QFT|rcsb pdb:4R14|rcsb pdb:4WSN|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|reactome:R-HSA-5696394|reactome:R-HSA-6781823|reactome:R-HSA-8856825|reactome:R-HSA-8951664|dip:DIP-32655N refseq:NP_000098.1|refseq:NP_001287663.1|ensembl:ENSG00000134574(gene)|ensembl:ENST00000256996(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0003677"(DNA binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006290"(pyrimidine dimer repair)|go:"GO:0009411"(response to UV)|go:"GO:0030054"(cell junction)|go:"GO:0031465"(Cul4B-RING E3 ubiquitin ligase complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035518"(histone H2A monoubiquitination)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0070914"(UV-damage excision repair)|go:"GO:0080008"(Cul4-RING E3 ubiquitin ligase complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR033312|interpro:IPR036322|rcsb pdb:3EI4|rcsb pdb:3I7L|rcsb pdb:4E54|rcsb pdb:4E5Z|rcsb pdb:6R8Y|rcsb pdb:6R8Z|rcsb pdb:6R90|rcsb pdb:6R91|rcsb pdb:6R92|reactome:R-HSA-5689880|reactome:R-HSA-5696394|reactome:R-HSA-5696395|reactome:R-HSA-5696400|reactome:R-HSA-6796648|reactome:R-HSA-8951664|dip:DIP-36670N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2020/10/21 rogid:hyuYyAujJCJtbfS2tJ+UgH7jWP89606 rogid:HkT35Q/boNG3Gc5ZH4PzTwrMebU9606 intact-crc:B58AF288F9C81A77|rigid:/fWQJTQK1fD0fpKu4c/6K/d+bMo false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q7L5N1 uniprotkb:Q9BW61 intact:EBI-486838|uniprotkb:O15387|uniprotkb:A4D2A3|ensembl:ENSP00000304102 intact:EBI-2510241|ensembl:ENSP00000352928|ensembl:ENSP00000472171|ensembl:ENSP00000473086 psi-mi:csn6_human(display_long)|uniprotkb:COPS6(gene name)|psi-mi:COPS6(display_short)|uniprotkb:CSN6(gene name synonym)|uniprotkb:HVIP(gene name synonym)|uniprotkb:JAB1-containing signalosome subunit 6(gene name synonym)|uniprotkb:Vpr-interacting protein(gene name synonym)|uniprotkb:MOV34 homolog(gene name synonym) psi-mi:dda1_human(display_long)|uniprotkb:DDA1(gene name)|psi-mi:DDA1(display_short)|uniprotkb:C19orf58(gene name synonym)|uniprotkb:PCIA1(gene name synonym)|uniprotkb:Placenta cross-immune reaction antigen 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510262|imex:IM-12079-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006824.2|ensembl:ENSG00000168090(gene)|ensembl:ENST00000303904(transcript)|go:"GO:0000338"(protein deneddylation)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070122"(isopeptidase activity)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR033859|interpro:IPR024969|interpro:IPR037518|mint:Q7L5N1|rcsb pdb:4D10|rcsb pdb:4D18|rcsb pdb:4QFT|rcsb pdb:4R14|rcsb pdb:4WSN|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|reactome:R-HSA-5696394|reactome:R-HSA-6781823|reactome:R-HSA-8856825|reactome:R-HSA-8951664|dip:DIP-32655N ensembl:ENSG00000130311(gene)|ensembl:ENST00000359866(transcript)|ensembl:ENST00000593466(transcript)|ensembl:ENST00000596582(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005654"(nucleoplasm)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0080008"(Cul4-RING E3 ubiquitin ligase complex)|interpro:IPR018276|interpro:IPR033575|mint:Q9BW61|rcsb pdb:6DSZ|rcsb pdb:6PAI|rcsb pdb:6Q0R|rcsb pdb:6Q0V|rcsb pdb:6Q0W|rcsb pdb:6SJ7|rcsb pdb:6UD7|rcsb pdb:6UE5|reactome:R-HSA-8951664|refseq:NP_076955.1|dip:DIP-53527N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2020/10/21 rogid:hyuYyAujJCJtbfS2tJ+UgH7jWP89606 rogid:yD3tRVKVhirdHUj58DCTphW7ZYs9606 intact-crc:B58AF288F9C81A77|rigid:/fWQJTQK1fD0fpKu4c/6K/d+bMo false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q7L5N1 uniprotkb:Q9BT78 intact:EBI-486838|uniprotkb:O15387|uniprotkb:A4D2A3|ensembl:ENSP00000304102 intact:EBI-742413|uniprotkb:Q561W7|uniprotkb:Q9NW31|uniprotkb:Q9Y677|uniprotkb:B3KN88|ensembl:ENSP00000264389|uniprotkb:B3KST5 psi-mi:csn6_human(display_long)|uniprotkb:COPS6(gene name)|psi-mi:COPS6(display_short)|uniprotkb:CSN6(gene name synonym)|uniprotkb:HVIP(gene name synonym)|uniprotkb:JAB1-containing signalosome subunit 6(gene name synonym)|uniprotkb:Vpr-interacting protein(gene name synonym)|uniprotkb:MOV34 homolog(gene name synonym) psi-mi:csn4_human(display_long)|uniprotkb:COPS4(gene name)|psi-mi:COPS4(display_short)|uniprotkb:CSN4(gene name synonym)|uniprotkb:JAB1-containing signalosome subunit 4(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510262|imex:IM-12079-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006824.2|ensembl:ENSG00000168090(gene)|ensembl:ENST00000303904(transcript)|go:"GO:0000338"(protein deneddylation)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070122"(isopeptidase activity)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR033859|interpro:IPR024969|interpro:IPR037518|mint:Q7L5N1|rcsb pdb:4D10|rcsb pdb:4D18|rcsb pdb:4QFT|rcsb pdb:4R14|rcsb pdb:4WSN|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|reactome:R-HSA-5696394|reactome:R-HSA-6781823|reactome:R-HSA-8856825|reactome:R-HSA-8951664|dip:DIP-32655N ensembl:ENSG00000138663(gene)|refseq:NP_057213.2|refseq:NP_001244935.1|go:"GO:0016607"(nuclear speck)|go:"GO:0019784"(NEDD8-specific protease activity)|go:"GO:0030054"(cell junction)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR036388|interpro:IPR036390|interpro:IPR037754|interpro:IPR040134|interpro:IPR041406|mint:Q9BT78|rcsb pdb:4D0P|rcsb pdb:4D10|rcsb pdb:4D18|rcsb pdb:4WSN|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|rcsb pdb:6R7N|reactome:R-HSA-5696394|reactome:R-HSA-6781823|reactome:R-HSA-8856825|reactome:R-HSA-8951664|reactome:R-HSA-9013422|ensembl:ENST00000264389(transcript)|go:"GO:0000338"(protein deneddylation)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008180"(COP9 signalosome)|refseq:NP_001317656.1|dip:DIP-34516N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2020/10/21 rogid:hyuYyAujJCJtbfS2tJ+UgH7jWP89606 rogid:onrZiPzG+bZvycmpDTZMtkPzCfQ9606 intact-crc:B58AF288F9C81A77|rigid:/fWQJTQK1fD0fpKu4c/6K/d+bMo false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q7L5N1 uniprotkb:Q647K1 intact:EBI-486838|uniprotkb:O15387|uniprotkb:A4D2A3|ensembl:ENSP00000304102 intact:EBI-2510264 psi-mi:csn6_human(display_long)|uniprotkb:COPS6(gene name)|psi-mi:COPS6(display_short)|uniprotkb:CSN6(gene name synonym)|uniprotkb:HVIP(gene name synonym)|uniprotkb:JAB1-containing signalosome subunit 6(gene name synonym)|uniprotkb:Vpr-interacting protein(gene name synonym)|uniprotkb:MOV34 homolog(gene name synonym) psi-mi:q647k1_human(display_long)|uniprotkb:KLHL18(gene name)|psi-mi:KLHL18(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510262|imex:IM-12079-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006824.2|ensembl:ENSG00000168090(gene)|ensembl:ENST00000303904(transcript)|go:"GO:0000338"(protein deneddylation)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070122"(isopeptidase activity)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR033859|interpro:IPR024969|interpro:IPR037518|mint:Q7L5N1|rcsb pdb:4D10|rcsb pdb:4D18|rcsb pdb:4QFT|rcsb pdb:4R14|rcsb pdb:4WSN|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|reactome:R-HSA-5696394|reactome:R-HSA-6781823|reactome:R-HSA-8856825|reactome:R-HSA-8951664|dip:DIP-32655N interpro:IPR011705(BTB/Kelch-associated)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR015915(Kelch-type beta propeller) psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2020/10/21 rogid:hyuYyAujJCJtbfS2tJ+UgH7jWP89606 rogid:I6q7BkeV4ANO7Af2mNzGZSWRttg9606 intact-crc:B58AF288F9C81A77|rigid:/fWQJTQK1fD0fpKu4c/6K/d+bMo false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q7L5N1 uniprotkb:Q9BX70 intact:EBI-486838|uniprotkb:O15387|uniprotkb:A4D2A3|ensembl:ENSP00000304102 intact:EBI-710091|uniprotkb:O60418|uniprotkb:O75248|uniprotkb:Q4VBZ1|uniprotkb:Q6IAC5|uniprotkb:Q7Z5W0|uniprotkb:Q96SX8|uniprotkb:Q9NPS1|uniprotkb:Q9NX81|ensembl:ENSP00000255608 psi-mi:csn6_human(display_long)|uniprotkb:COPS6(gene name)|psi-mi:COPS6(display_short)|uniprotkb:CSN6(gene name synonym)|uniprotkb:HVIP(gene name synonym)|uniprotkb:JAB1-containing signalosome subunit 6(gene name synonym)|uniprotkb:Vpr-interacting protein(gene name synonym)|uniprotkb:MOV34 homolog(gene name synonym) psi-mi:btbd2_human(display_long)|uniprotkb:BTBD2(gene name)|psi-mi:BTBD2(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510262|imex:IM-12079-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006824.2|ensembl:ENSG00000168090(gene)|ensembl:ENST00000303904(transcript)|go:"GO:0000338"(protein deneddylation)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070122"(isopeptidase activity)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR033859|interpro:IPR024969|interpro:IPR037518|mint:Q7L5N1|rcsb pdb:4D10|rcsb pdb:4D18|rcsb pdb:4QFT|rcsb pdb:4R14|rcsb pdb:4WSN|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|reactome:R-HSA-5696394|reactome:R-HSA-6781823|reactome:R-HSA-8856825|reactome:R-HSA-8951664|dip:DIP-32655N refseq:XP_011526429.1|refseq:NP_060267.2|ensembl:ENSG00000133243(gene)|ensembl:ENST00000255608(transcript)|go:"GO:0000932"(P-body)|go:"GO:0005829"(cytosol)|go:"GO:0022008"(neurogenesis)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR011705(BTB/Kelch-associated)|interpro:IPR012983(PHR)|interpro:IPR038648|mint:Q9BX70|rcsb pdb:3NO8 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2020/10/21 rogid:hyuYyAujJCJtbfS2tJ+UgH7jWP89606 rogid:/G2pfpWgbGkgFcMLzMcWg5isDOE9606 intact-crc:B58AF288F9C81A77|rigid:/fWQJTQK1fD0fpKu4c/6K/d+bMo false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q7L5N1 uniprotkb:Q9P2G9 intact:EBI-486838|uniprotkb:O15387|uniprotkb:A4D2A3|ensembl:ENSP00000304102 intact:EBI-949008|uniprotkb:Q53XA3|ensembl:ENSP00000273963|ensembl:ENSP00000424131|uniprotkb:Q6N018|intact:EBI-11068414 psi-mi:csn6_human(display_long)|uniprotkb:COPS6(gene name)|psi-mi:COPS6(display_short)|uniprotkb:CSN6(gene name synonym)|uniprotkb:HVIP(gene name synonym)|uniprotkb:JAB1-containing signalosome subunit 6(gene name synonym)|uniprotkb:Vpr-interacting protein(gene name synonym)|uniprotkb:MOV34 homolog(gene name synonym) psi-mi:klhl8_human(display_long)|uniprotkb:KLHL8(gene name)|psi-mi:KLHL8(display_short)|uniprotkb:KIAA1378(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510262|imex:IM-12079-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006824.2|ensembl:ENSG00000168090(gene)|ensembl:ENST00000303904(transcript)|go:"GO:0000338"(protein deneddylation)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070122"(isopeptidase activity)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR033859|interpro:IPR024969|interpro:IPR037518|mint:Q7L5N1|rcsb pdb:4D10|rcsb pdb:4D18|rcsb pdb:4QFT|rcsb pdb:4R14|rcsb pdb:4WSN|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|reactome:R-HSA-5696394|reactome:R-HSA-6781823|reactome:R-HSA-8856825|reactome:R-HSA-8951664|dip:DIP-32655N ensembl:ENSG00000145332(gene)|ensembl:ENST00000273963(transcript)|ensembl:ENST00000512111(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR011043(Galactose oxidase/kelch, beta-propeller)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR011705(BTB/Kelch-associated)|interpro:IPR015915(Kelch-type beta propeller)|interpro:IPR017096(Kelch-like protein, gigaxonin)|interpro:IPR030605|refseq:NP_065854.3|refseq:NP_001278932.1|refseq:NP_001278935.1|refseq:NP_001278936.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2020/10/21 rogid:hyuYyAujJCJtbfS2tJ+UgH7jWP89606 rogid:4K/fcscSuNoBm6n3AQ2RFMbNjYs9606 intact-crc:B58AF288F9C81A77|rigid:/fWQJTQK1fD0fpKu4c/6K/d+bMo false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q7L5N1 uniprotkb:Q9Y597 intact:EBI-486838|uniprotkb:O15387|uniprotkb:A4D2A3|ensembl:ENSP00000304102 intact:EBI-373299|uniprotkb:A0AV15|uniprotkb:Q49AG7|uniprotkb:Q504Q9|uniprotkb:Q6PJN6|uniprotkb:Q8ND58|uniprotkb:Q8NDJ0|uniprotkb:Q8WX16|uniprotkb:D3DTA6|ensembl:ENSP00000259154 psi-mi:csn6_human(display_long)|uniprotkb:COPS6(gene name)|psi-mi:COPS6(display_short)|uniprotkb:CSN6(gene name synonym)|uniprotkb:HVIP(gene name synonym)|uniprotkb:JAB1-containing signalosome subunit 6(gene name synonym)|uniprotkb:Vpr-interacting protein(gene name synonym)|uniprotkb:MOV34 homolog(gene name synonym) psi-mi:kctd3_human(display_long)|uniprotkb:KCTD3(gene name)|psi-mi:KCTD3(display_short)|uniprotkb:Renal carcinoma antigen NY-REN-45(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510262|imex:IM-12079-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006824.2|ensembl:ENSG00000168090(gene)|ensembl:ENST00000303904(transcript)|go:"GO:0000338"(protein deneddylation)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070122"(isopeptidase activity)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR033859|interpro:IPR024969|interpro:IPR037518|mint:Q7L5N1|rcsb pdb:4D10|rcsb pdb:4D18|rcsb pdb:4QFT|rcsb pdb:4R14|rcsb pdb:4WSN|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|reactome:R-HSA-5696394|reactome:R-HSA-6781823|reactome:R-HSA-8856825|reactome:R-HSA-8951664|dip:DIP-32655N refseq:NP_057205.2|refseq:NP_001306223.1|refseq:NP_001306224.1|ensembl:ENST00000259154(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0051260"(protein homooligomerization)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR001680(WD40 repeat)|interpro:IPR003131(Potassium channel, voltage dependent, Kv, tetramerisation)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR036322|reactome:R-HSA-9013148|ensembl:ENSG00000136636(gene) psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2020/10/21 rogid:hyuYyAujJCJtbfS2tJ+UgH7jWP89606 rogid:rd5uwUaxsHyv815HcLJmrI3sgNQ9606 intact-crc:B58AF288F9C81A77|rigid:/fWQJTQK1fD0fpKu4c/6K/d+bMo false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q7L5N1 uniprotkb:Q9H9Q2 intact:EBI-486838|uniprotkb:O15387|uniprotkb:A4D2A3|ensembl:ENSP00000304102 intact:EBI-2510162|ensembl:ENSP00000272995|ensembl:ENSP00000386567|uniprotkb:Q53S22|uniprotkb:Q5BJG3|uniprotkb:Q9H7V6 psi-mi:csn6_human(display_long)|uniprotkb:COPS6(gene name)|psi-mi:COPS6(display_short)|uniprotkb:CSN6(gene name synonym)|uniprotkb:HVIP(gene name synonym)|uniprotkb:JAB1-containing signalosome subunit 6(gene name synonym)|uniprotkb:Vpr-interacting protein(gene name synonym)|uniprotkb:MOV34 homolog(gene name synonym) psi-mi:csn7b_human(display_long)|uniprotkb:COPS7B(gene name)|psi-mi:COPS7B(display_short)|uniprotkb:CSN7B(gene name synonym)|uniprotkb:JAB1-containing signalosome subunit 7b(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510262|imex:IM-12079-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006824.2|ensembl:ENSG00000168090(gene)|ensembl:ENST00000303904(transcript)|go:"GO:0000338"(protein deneddylation)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070122"(isopeptidase activity)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR033859|interpro:IPR024969|interpro:IPR037518|mint:Q7L5N1|rcsb pdb:4D10|rcsb pdb:4D18|rcsb pdb:4QFT|rcsb pdb:4R14|rcsb pdb:4WSN|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|reactome:R-HSA-5696394|reactome:R-HSA-6781823|reactome:R-HSA-8856825|reactome:R-HSA-8951664|dip:DIP-32655N refseq:NP_001269879.1|refseq:NP_001269881.1|ensembl:ENSG00000144524(gene)|ensembl:ENST00000350033(transcript)|ensembl:ENST00000410024(transcript)|go:"GO:0000338"(protein deneddylation)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0010387"(COP9 signalosome assembly)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR041481|mint:Q9H9Q2|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|interpro:IPR027530|rcsb pdb:6R7I|rcsb pdb:6R7N|reactome:R-HSA-5696394|reactome:R-HSA-6781823|reactome:R-HSA-8856825|reactome:R-HSA-8951664|refseq:NP_073567.1|refseq:XP_016860205.1|refseq:XP_016860206.1|dip:DIP-53525N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2020/10/21 rogid:hyuYyAujJCJtbfS2tJ+UgH7jWP89606 rogid:Q4rrTMRm/aOT/uIBaELCKNCZd9c9606 intact-crc:B58AF288F9C81A77|rigid:/fWQJTQK1fD0fpKu4c/6K/d+bMo false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q7L5N1 uniprotkb:P61201 intact:EBI-486838|uniprotkb:O15387|uniprotkb:A4D2A3|ensembl:ENSP00000304102 intact:EBI-1050386|uniprotkb:O88950|uniprotkb:Q15647|uniprotkb:Q6FGP4|uniprotkb:Q9BY54|uniprotkb:Q9R249|uniprotkb:Q9UNI2|uniprotkb:Q9UNQ5|ensembl:ENSP00000373553 psi-mi:csn6_human(display_long)|uniprotkb:COPS6(gene name)|psi-mi:COPS6(display_short)|uniprotkb:CSN6(gene name synonym)|uniprotkb:HVIP(gene name synonym)|uniprotkb:JAB1-containing signalosome subunit 6(gene name synonym)|uniprotkb:Vpr-interacting protein(gene name synonym)|uniprotkb:MOV34 homolog(gene name synonym) psi-mi:csn2_human(display_long)|uniprotkb:JAB1-containing signalosome subunit 2(gene name synonym)|uniprotkb:Thyroid receptor-interacting protein 15(gene name synonym)|uniprotkb:Alien homolog(gene name synonym)|uniprotkb:COPS2(gene name)|psi-mi:COPS2(display_short)|uniprotkb:CSN2(gene name synonym)|uniprotkb:TRIP15(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510262|imex:IM-12079-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006824.2|ensembl:ENSG00000168090(gene)|ensembl:ENST00000303904(transcript)|go:"GO:0000338"(protein deneddylation)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070122"(isopeptidase activity)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR033859|interpro:IPR024969|interpro:IPR037518|mint:Q7L5N1|rcsb pdb:4D10|rcsb pdb:4D18|rcsb pdb:4QFT|rcsb pdb:4R14|rcsb pdb:4WSN|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|reactome:R-HSA-5696394|reactome:R-HSA-6781823|reactome:R-HSA-8856825|reactome:R-HSA-8951664|dip:DIP-32655N refseq:NP_001137359.1|refseq:NP_004227.1|ensembl:ENSG00000166200(gene)|ensembl:ENST00000388901(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000338"(protein deneddylation)|go:"GO:0001833"(inner cell mass cell proliferation)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0030182"(neuron differentiation)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:1903507"(negative regulation of nucleic acid-templated transcription)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR036390|interpro:IPR037750|mint:P61201|rcsb pdb:4D10|rcsb pdb:4D18|rcsb pdb:4WSN|rcsb pdb:6A73|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|rcsb pdb:6R7N|reactome:R-HSA-5696394|reactome:R-HSA-6781823|reactome:R-HSA-8856825|reactome:R-HSA-8951664|reactome:R-HSA-9013422|dip:DIP-42076N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2020/10/21 rogid:hyuYyAujJCJtbfS2tJ+UgH7jWP89606 rogid:MrlEHktIBvvcQux7Z7kqYJYgbbs9606 intact-crc:B58AF288F9C81A77|rigid:/fWQJTQK1fD0fpKu4c/6K/d+bMo false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q7L5N1 uniprotkb:Q9Y2M5 intact:EBI-486838|uniprotkb:O15387|uniprotkb:A4D2A3|ensembl:ENSP00000304102 intact:EBI-714379|ensembl:ENSP00000209884|uniprotkb:Q5TZF2|uniprotkb:Q9H457|uniprotkb:B3KMA0|uniprotkb:Q5ZF45|uniprotkb:B4DUR0 psi-mi:csn6_human(display_long)|uniprotkb:COPS6(gene name)|psi-mi:COPS6(display_short)|uniprotkb:CSN6(gene name synonym)|uniprotkb:HVIP(gene name synonym)|uniprotkb:JAB1-containing signalosome subunit 6(gene name synonym)|uniprotkb:Vpr-interacting protein(gene name synonym)|uniprotkb:MOV34 homolog(gene name synonym) psi-mi:klh20_human(display_long)|uniprotkb:KLHL20(gene name)|psi-mi:KLHL20(display_short)|uniprotkb:KLEIP(gene name synonym)|uniprotkb:Kelch-like ECT2-interacting protein(gene name synonym)|uniprotkb:Kelch-like protein X(gene name synonym)|uniprotkb:KLHLX(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510262|imex:IM-12079-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006824.2|ensembl:ENSG00000168090(gene)|ensembl:ENST00000303904(transcript)|go:"GO:0000338"(protein deneddylation)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070122"(isopeptidase activity)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR033859|interpro:IPR024969|interpro:IPR037518|mint:Q7L5N1|rcsb pdb:4D10|rcsb pdb:4D18|rcsb pdb:4QFT|rcsb pdb:4R14|rcsb pdb:4WSN|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|reactome:R-HSA-5696394|reactome:R-HSA-6781823|reactome:R-HSA-8856825|reactome:R-HSA-8951664|dip:DIP-32655N reactome:R-HSA-983168|go:"GO:0035455"(response to interferon-alpha)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:1990390"(protein K33-linked ubiquitination)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR011705(BTB/Kelch-associated)|interpro:IPR015915(Kelch-type beta propeller)|interpro:IPR017096(Kelch-like protein, gigaxonin)|interpro:IPR030594|mint:Q9Y2M5|rcsb pdb:5YQ4|rcsb pdb:6GY5|reactome:R-HSA-8951664|ensembl:ENSG00000076321(gene)|ensembl:ENST00000209884(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0006895"(Golgi to endosome transport)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0015031"(protein transport)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016605"(PML body)|go:"GO:0019964"(interferon-gamma binding)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|refseq:NP_055273.2|refseq:XP_005245150.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2020/10/21 rogid:hyuYyAujJCJtbfS2tJ+UgH7jWP89606 rogid:3MyNIHmvjvjumxy4csUdrbMg5wI9606 intact-crc:B58AF288F9C81A77|rigid:/fWQJTQK1fD0fpKu4c/6K/d+bMo false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q7L5N1 uniprotkb:Q96L50 intact:EBI-486838|uniprotkb:O15387|uniprotkb:A4D2A3|ensembl:ENSP00000304102 intact:EBI-2510106|uniprotkb:B4DDE0|ensembl:ENSP00000298288|uniprotkb:A5D6X3|uniprotkb:Q52M24|uniprotkb:Q8N6H9|uniprotkb:Q86SZ1 psi-mi:csn6_human(display_long)|uniprotkb:COPS6(gene name)|psi-mi:COPS6(display_short)|uniprotkb:CSN6(gene name synonym)|uniprotkb:HVIP(gene name synonym)|uniprotkb:JAB1-containing signalosome subunit 6(gene name synonym)|uniprotkb:Vpr-interacting protein(gene name synonym)|uniprotkb:MOV34 homolog(gene name synonym) psi-mi:llr1_human(display_long)|uniprotkb:LRR1(gene name)|psi-mi:LRR1(display_short)|uniprotkb:PPIL5(gene name synonym)|uniprotkb:LRR-repeat protein 1(gene name synonym)|uniprotkb:4-1BB-mediated-signaling molecule(gene name synonym)|uniprotkb:4-1BBlrr(gene name synonym)|uniprotkb:Peptidylprolyl isomerase-like 5(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510262|imex:IM-12079-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006824.2|ensembl:ENSG00000168090(gene)|ensembl:ENST00000303904(transcript)|go:"GO:0000338"(protein deneddylation)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070122"(isopeptidase activity)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR033859|interpro:IPR024969|interpro:IPR037518|mint:Q7L5N1|rcsb pdb:4D10|rcsb pdb:4D18|rcsb pdb:4QFT|rcsb pdb:4R14|rcsb pdb:4WSN|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|reactome:R-HSA-5696394|reactome:R-HSA-6781823|reactome:R-HSA-8856825|reactome:R-HSA-8951664|dip:DIP-32655N ensembl:ENSG00000165501(gene)|ensembl:ENST00000298288(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0016567"(protein ubiquitination)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR025875|interpro:IPR032675|reactome:R-HSA-8951664|reactome:R-HSA-983168|refseq:NP_689542.2|refseq:NP_982292.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2020/10/21 rogid:hyuYyAujJCJtbfS2tJ+UgH7jWP89606 rogid:7znZddT/rr1wCuorp9l6jxzsujE9606 intact-crc:B58AF288F9C81A77|rigid:/fWQJTQK1fD0fpKu4c/6K/d+bMo false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q7L5N1 uniprotkb:Q13098 intact:EBI-486838|uniprotkb:O15387|uniprotkb:A4D2A3|ensembl:ENSP00000304102 intact:EBI-725197|uniprotkb:Q8NA10|uniprotkb:Q9BWL1|ensembl:ENSP00000302873 psi-mi:csn6_human(display_long)|uniprotkb:COPS6(gene name)|psi-mi:COPS6(display_short)|uniprotkb:CSN6(gene name synonym)|uniprotkb:HVIP(gene name synonym)|uniprotkb:JAB1-containing signalosome subunit 6(gene name synonym)|uniprotkb:Vpr-interacting protein(gene name synonym)|uniprotkb:MOV34 homolog(gene name synonym) psi-mi:csn1_human(display_long)|uniprotkb:JAB1-containing signalosome subunit 1(gene name synonym)|uniprotkb:G protein pathway suppressor 1(gene name synonym)|uniprotkb:Protein MFH(gene name synonym)|uniprotkb:GPS1(gene name)|psi-mi:GPS1(display_short)|uniprotkb:COPS1(gene name synonym)|uniprotkb:CSN1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510262|imex:IM-12079-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006824.2|ensembl:ENSG00000168090(gene)|ensembl:ENST00000303904(transcript)|go:"GO:0000338"(protein deneddylation)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070122"(isopeptidase activity)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR033859|interpro:IPR024969|interpro:IPR037518|mint:Q7L5N1|rcsb pdb:4D10|rcsb pdb:4D18|rcsb pdb:4QFT|rcsb pdb:4R14|rcsb pdb:4WSN|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|reactome:R-HSA-5696394|reactome:R-HSA-6781823|reactome:R-HSA-8856825|reactome:R-HSA-8951664|dip:DIP-32655N refseq:NP_004118.3|refseq:NP_997657.1|ensembl:ENSG00000169727(gene)|ensembl:ENST00000306823(transcript)|go:"GO:0000188"(obsolete inactivation of MAPK activity)|go:"GO:0000338"(protein deneddylation)|go:"GO:0005095"(GTPase inhibitor activity)|go:"GO:0005654"(nucleoplasm)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR019585|interpro:IPR033008|interpro:IPR036390|mint:Q13098|rcsb pdb:4D10|rcsb pdb:4D18|rcsb pdb:4WSN|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|rcsb pdb:6R7N|go:"GO:0005829"(cytosol)|go:"GO:0007254"(JNK cascade)|go:"GO:0008180"(COP9 signalosome)|reactome:R-HSA-5696394|reactome:R-HSA-6781823|reactome:R-HSA-8856825|reactome:R-HSA-8951664|reactome:R-HSA-9013422|refseq:NP_001308021.1|refseq:XP_016880023.1|dip:DIP-42077N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2020/10/21 rogid:hyuYyAujJCJtbfS2tJ+UgH7jWP89606 rogid:OMWZ67qcgKTM0R/hy8L2oCa3cpo9606 intact-crc:B58AF288F9C81A77|rigid:/fWQJTQK1fD0fpKu4c/6K/d+bMo false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q7L5N1 uniprotkb:Q9Y4B6 intact:EBI-486838|uniprotkb:O15387|uniprotkb:A4D2A3|ensembl:ENSP00000304102 intact:EBI-1996353|uniprotkb:Q2YD74|uniprotkb:Q8TBD9|uniprotkb:Q9HCA1|uniprotkb:Q9UG37|intact:EBI-2559078|intact:EBI-28988191|ensembl:ENSP00000393183|ensembl:ENSP00000506880 psi-mi:csn6_human(display_long)|uniprotkb:COPS6(gene name)|psi-mi:COPS6(display_short)|uniprotkb:CSN6(gene name synonym)|uniprotkb:HVIP(gene name synonym)|uniprotkb:JAB1-containing signalosome subunit 6(gene name synonym)|uniprotkb:Vpr-interacting protein(gene name synonym)|uniprotkb:MOV34 homolog(gene name synonym) psi-mi:dcaf1_human(display_long)|uniprotkb:DCAF1(gene name)|psi-mi:DCAF1(display_short)|uniprotkb:HIV-1 Vpr-binding protein(gene name synonym)|uniprotkb:KIAA0800(gene name synonym)|uniprotkb:RIP(gene name synonym)|uniprotkb:Serine/threonine-protein kinase VPRBP(gene name synonym)|uniprotkb:VPRBP(gene name synonym)|uniprotkb:Vpr-interacting protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510262|imex:IM-12079-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006824.2|ensembl:ENSG00000168090(gene)|ensembl:ENST00000303904(transcript)|go:"GO:0000338"(protein deneddylation)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070122"(isopeptidase activity)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR033859|interpro:IPR024969|interpro:IPR037518|mint:Q7L5N1|rcsb pdb:4D10|rcsb pdb:4D18|rcsb pdb:4QFT|rcsb pdb:4R14|rcsb pdb:4WSN|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|reactome:R-HSA-5696394|reactome:R-HSA-6781823|reactome:R-HSA-8856825|reactome:R-HSA-8951664|dip:DIP-32655N refseq:NP_001165375.1|refseq:NP_055518.1|refseq:XP_011532575.1|refseq:XP_011532576.1|refseq:XP_011532577.1|refseq:XP_011532578.1|refseq:XP_011532579.1|refseq:XP_016863035.1|refseq:XP_016863036.1|refseq:XP_016863037.1|refseq:XP_016863038.1|refseq:XP_016863039.1|ensembl:ENST00000335891|ensembl:ENSP00000338857|ensembl:ENSP00000393183|ensembl:ENST00000504652|ensembl:ENSP00000421724|ensembl:ENSP00000506880|ensembl:ENSG00000145041(gene)|ensembl:ENST00000423656(transcript)|ensembl:ENST00000684031(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001650"(fibrillar center)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0033151"("V(D)J recombination")|go:"GO:0035212"(cell competition in a multicellular organism)|go:"GO:0080008"(Cul4-RING E3 ubiquitin ligase complex)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1990244"("histone kinase activity (H2A-T120 specific)")|go:"GO:1990245"(histone H2A-T120 phosphorylation)|interpro:IPR006594(LisH dimerisation motif)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR033270|interpro:IPR036322|mint:Q9Y4B6|rcsb pdb:3WA0|rcsb pdb:4CC9|rcsb pdb:4P7I|rcsb pdb:4PXW|rcsb pdb:4Z8L|rcsb pdb:5AJA|rcsb pdb:5JK7|rcsb pdb:6N45|reactome:R-HSA-983168|refseq:XP_005276810.1|refseq:XP_005276812.1|dip:DIP-47048N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2020/10/21 rogid:hyuYyAujJCJtbfS2tJ+UgH7jWP89606 rogid:qs3qG0MM135EE/DjC1S/gCLRFhc9606 intact-crc:B58AF288F9C81A77|rigid:/fWQJTQK1fD0fpKu4c/6K/d+bMo false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q7L5N1 uniprotkb:Q9H0C5 intact:EBI-486838|uniprotkb:O15387|uniprotkb:A4D2A3|ensembl:ENSP00000304102 intact:EBI-935503|uniprotkb:A6NMI8|uniprotkb:Q9BX71|uniprotkb:Q9NWN4|ensembl:ENSP00000261721 psi-mi:csn6_human(display_long)|uniprotkb:COPS6(gene name)|psi-mi:COPS6(display_short)|uniprotkb:CSN6(gene name synonym)|uniprotkb:HVIP(gene name synonym)|uniprotkb:JAB1-containing signalosome subunit 6(gene name synonym)|uniprotkb:Vpr-interacting protein(gene name synonym)|uniprotkb:MOV34 homolog(gene name synonym) psi-mi:btbd1_human(display_long)|uniprotkb:BTBD1(gene name)|psi-mi:BTBD1(display_short)|uniprotkb:C15orf1(gene name synonym)|uniprotkb:Hepatitis C virus NS5A-transactivated protein 8(gene name synonym)|uniprotkb:NS5ATP8(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510262|imex:IM-12079-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006824.2|ensembl:ENSG00000168090(gene)|ensembl:ENST00000303904(transcript)|go:"GO:0000338"(protein deneddylation)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070122"(isopeptidase activity)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR033859|interpro:IPR024969|interpro:IPR037518|mint:Q7L5N1|rcsb pdb:4D10|rcsb pdb:4D18|rcsb pdb:4QFT|rcsb pdb:4R14|rcsb pdb:4WSN|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|reactome:R-HSA-5696394|reactome:R-HSA-6781823|reactome:R-HSA-8856825|reactome:R-HSA-8951664|dip:DIP-32655N refseq:NP_001011885.1|refseq:NP_079514.1|ensembl:ENSG00000064726(gene)|ensembl:ENST00000261721(transcript)|go:"GO:0000932"(P-body)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007517"(muscle organ development)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0022008"(neurogenesis)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0097602"(cullin family protein binding)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR011705(BTB/Kelch-associated)|interpro:IPR012983(PHR)|interpro:IPR038648|reactome:R-HSA-8951664|reactome:R-HSA-983168 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2020/10/21 rogid:hyuYyAujJCJtbfS2tJ+UgH7jWP89606 rogid:fRSh7JVRI2O2o8m7WCEjydcX1QM9606 intact-crc:B58AF288F9C81A77|rigid:/fWQJTQK1fD0fpKu4c/6K/d+bMo false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q7L5N1 uniprotkb:P61024 intact:EBI-486838|uniprotkb:O15387|uniprotkb:A4D2A3|ensembl:ENSP00000304102 intact:EBI-456371|uniprotkb:P33551|ensembl:ENSP00000311083 psi-mi:csn6_human(display_long)|uniprotkb:COPS6(gene name)|psi-mi:COPS6(display_short)|uniprotkb:CSN6(gene name synonym)|uniprotkb:HVIP(gene name synonym)|uniprotkb:JAB1-containing signalosome subunit 6(gene name synonym)|uniprotkb:Vpr-interacting protein(gene name synonym)|uniprotkb:MOV34 homolog(gene name synonym) psi-mi:cks1_human(display_long)|uniprotkb:PNAS-16(orf name)|uniprotkb:PNAS-143(orf name)|uniprotkb:CKS1B(gene name)|psi-mi:CKS1B(display_short)|uniprotkb:CKS1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510262|imex:IM-12079-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006824.2|ensembl:ENSG00000168090(gene)|ensembl:ENST00000303904(transcript)|go:"GO:0000338"(protein deneddylation)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070122"(isopeptidase activity)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR033859|interpro:IPR024969|interpro:IPR037518|mint:Q7L5N1|rcsb pdb:4D10|rcsb pdb:4D18|rcsb pdb:4QFT|rcsb pdb:4R14|rcsb pdb:4WSN|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|reactome:R-HSA-5696394|reactome:R-HSA-6781823|reactome:R-HSA-8856825|reactome:R-HSA-8951664|dip:DIP-32655N refseq:NP_001817.1|dip:DIP-102N|rcsb pdb:4YC6|rcsb pdb:7B5L|rcsb pdb:7B5M|rcsb pdb:7B5R|reactome:R-HSA-187577|reactome:R-HSA-69231|ensembl:ENSG00000173207(gene)|ensembl:ENST00000308987(transcript)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0005654"(nucleoplasm)|go:"GO:0007049"(cell cycle)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0019901"(protein kinase binding)|go:"GO:0042393"(histone binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0051301"(cell division)|go:"GO:0061575"(cyclin-dependent protein serine/threonine kinase activator activity)|interpro:IPR000789(Cyclin-dependent kinase, regulatory subunit)|interpro:IPR036858|mint:P61024|rcsb pdb:1BUH|rcsb pdb:1DKS|rcsb pdb:1DKT|rcsb pdb:2ASS|rcsb pdb:2AST psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2020/10/21 rogid:hyuYyAujJCJtbfS2tJ+UgH7jWP89606 rogid:ANoFqi0sBqFKOAyhcMhTWA9kghY9606 intact-crc:B58AF288F9C81A77|rigid:/fWQJTQK1fD0fpKu4c/6K/d+bMo false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q7L5N1 uniprotkb:Q5XUX1 intact:EBI-486838|uniprotkb:O15387|uniprotkb:A4D2A3|ensembl:ENSP00000304102 intact:EBI-2322729|uniprotkb:B3KVP7|uniprotkb:Q9BT89|ensembl:ENSP00000376945 psi-mi:csn6_human(display_long)|uniprotkb:COPS6(gene name)|psi-mi:COPS6(display_short)|uniprotkb:CSN6(gene name synonym)|uniprotkb:HVIP(gene name synonym)|uniprotkb:JAB1-containing signalosome subunit 6(gene name synonym)|uniprotkb:Vpr-interacting protein(gene name synonym)|uniprotkb:MOV34 homolog(gene name synonym) psi-mi:fbxw9_human(display_long)|uniprotkb:FBXW9(gene name)|psi-mi:FBXW9(display_short)|uniprotkb:FBW9(gene name synonym)|uniprotkb:F-box and WD-40 domain-containing protein 9(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510262|imex:IM-12079-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006824.2|ensembl:ENSG00000168090(gene)|ensembl:ENST00000303904(transcript)|go:"GO:0000338"(protein deneddylation)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070122"(isopeptidase activity)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR033859|interpro:IPR024969|interpro:IPR037518|mint:Q7L5N1|rcsb pdb:4D10|rcsb pdb:4D18|rcsb pdb:4QFT|rcsb pdb:4R14|rcsb pdb:4WSN|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|reactome:R-HSA-5696394|reactome:R-HSA-6781823|reactome:R-HSA-8856825|reactome:R-HSA-8951664|dip:DIP-32655N refseq:NP_115677.2|ensembl:ENSG00000132004(gene)|ensembl:ENST00000393261(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0030687"(preribosome, large subunit precursor)|interpro:IPR001680(WD40 repeat)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036047|interpro:IPR036322|reactome:R-HSA-390471|reactome:R-HSA-8951664|reactome:R-HSA-983168 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2020/10/21 rogid:hyuYyAujJCJtbfS2tJ+UgH7jWP89606 rogid:srCRaEUd/tjElP41q22zfIRLvCM9606 intact-crc:B58AF288F9C81A77|rigid:/fWQJTQK1fD0fpKu4c/6K/d+bMo false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q7L5N1 uniprotkb:Q15843 intact:EBI-486838|uniprotkb:O15387|uniprotkb:A4D2A3|ensembl:ENSP00000304102 intact:EBI-716247|uniprotkb:Q3SXN8|uniprotkb:Q6LES6|ensembl:ENSP00000250495|ensembl:ENSP00000496420 psi-mi:csn6_human(display_long)|uniprotkb:COPS6(gene name)|psi-mi:COPS6(display_short)|uniprotkb:CSN6(gene name synonym)|uniprotkb:HVIP(gene name synonym)|uniprotkb:JAB1-containing signalosome subunit 6(gene name synonym)|uniprotkb:Vpr-interacting protein(gene name synonym)|uniprotkb:MOV34 homolog(gene name synonym) psi-mi:nedd8_human(display_long)|uniprotkb:Ubiquitin-like protein Nedd8(gene name synonym)|uniprotkb:Neddylin(gene name synonym)|uniprotkb:Neural precursor cell expressed developmentally down-regulated protein 8(gene name synonym)|uniprotkb:NEDD8(gene name)|psi-mi:NEDD8(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510262|imex:IM-12079-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006824.2|ensembl:ENSG00000168090(gene)|ensembl:ENST00000303904(transcript)|go:"GO:0000338"(protein deneddylation)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070122"(isopeptidase activity)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR033859|interpro:IPR024969|interpro:IPR037518|mint:Q7L5N1|rcsb pdb:4D10|rcsb pdb:4D18|rcsb pdb:4QFT|rcsb pdb:4R14|rcsb pdb:4WSN|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|reactome:R-HSA-5696394|reactome:R-HSA-6781823|reactome:R-HSA-8856825|reactome:R-HSA-8951664|dip:DIP-32655N refseq:NP_006147.1|ensembl:ENSG00000129559(gene)|ensembl:ENSG00000285246(gene)|ensembl:ENST00000250495(transcript)|ensembl:ENST00000643069(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006508"(proteolysis)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008104"(protein localization)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0019941"(modification-dependent protein catabolic process)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0031386"(protein tag)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0045116"(protein neddylation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000626(Ubiquitin)|interpro:IPR019954|interpro:IPR019956|interpro:IPR029071|interpro:IPR038738|mint:Q15843|rcsb pdb:1NDD|rcsb pdb:1R4M|rcsb pdb:1R4N|rcsb pdb:1XT9|rcsb pdb:2BKR|rcsb pdb:2KO3|rcsb pdb:2N7K|rcsb pdb:2NVU|rcsb pdb:3DBH|rcsb pdb:3DBL|rcsb pdb:3DBR|rcsb pdb:3DQV|rcsb pdb:3GZN|rcsb pdb:4F8C|rcsb pdb:4FBJ|rcsb pdb:4HCP|rcsb pdb:4P5O|rcsb pdb:6R7F|rcsb pdb:6R7I|rcsb pdb:6TTU|rcsb pdb:7B5L|rcsb pdb:7B5N|reactome:R-HSA-2173789|reactome:R-HSA-5689603|reactome:R-HSA-8856825|reactome:R-HSA-8951664|reactome:R-HSA-917937|dip:DIP-29266N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2020/10/21 rogid:hyuYyAujJCJtbfS2tJ+UgH7jWP89606 rogid:qB1KNoIOwa1ONfphWDWjJri9hwE9606 intact-crc:B58AF288F9C81A77|rigid:/fWQJTQK1fD0fpKu4c/6K/d+bMo false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q7L5N1 uniprotkb:Q9P2N7 intact:EBI-486838|uniprotkb:O15387|uniprotkb:A4D2A3|ensembl:ENSP00000304102 intact:EBI-1996321|uniprotkb:D3DWH6|uniprotkb:Q6P2E3|uniprotkb:Q96QI7|uniprotkb:Q9UDN9|uniprotkb:B3KV78|uniprotkb:B3KWM7|uniprotkb:B7Z3S9|uniprotkb:B7Z5P2|uniprotkb:B7Z802|ensembl:ENSP00000262820 psi-mi:csn6_human(display_long)|uniprotkb:COPS6(gene name)|psi-mi:COPS6(display_short)|uniprotkb:CSN6(gene name synonym)|uniprotkb:HVIP(gene name synonym)|uniprotkb:JAB1-containing signalosome subunit 6(gene name synonym)|uniprotkb:Vpr-interacting protein(gene name synonym)|uniprotkb:MOV34 homolog(gene name synonym) psi-mi:klh13_human(display_long)|uniprotkb:KLHL13(gene name)|psi-mi:KLHL13(display_short)|uniprotkb:BKLHD2(gene name synonym)|uniprotkb:KIAA1309(gene name synonym)|uniprotkb:BTB and kelch domain-containing protein 2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510262|imex:IM-12079-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006824.2|ensembl:ENSG00000168090(gene)|ensembl:ENST00000303904(transcript)|go:"GO:0000338"(protein deneddylation)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070122"(isopeptidase activity)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR033859|interpro:IPR024969|interpro:IPR037518|mint:Q7L5N1|rcsb pdb:4D10|rcsb pdb:4D18|rcsb pdb:4QFT|rcsb pdb:4R14|rcsb pdb:4WSN|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|reactome:R-HSA-5696394|reactome:R-HSA-6781823|reactome:R-HSA-8856825|reactome:R-HSA-8951664|dip:DIP-32655N refseq:NP_001161771.1|refseq:NP_001161772.1|refseq:NP_001161773.1|refseq:NP_001161774.1|refseq:NP_001161775.1|refseq:NP_277030.2|refseq:XP_011529713.1|refseq:XP_016885439.1|interpro:IPR017096(Kelch-like protein, gigaxonin)|reactome:R-HSA-8951664|reactome:R-HSA-983168|ensembl:ENSG00000003096(gene)|ensembl:ENST00000262820(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0007049"(cell cycle)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030496"(midbody)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0051301"(cell division)|go:"GO:0097602"(cullin family protein binding)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR011705(BTB/Kelch-associated)|interpro:IPR015915(Kelch-type beta propeller) psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2020/10/21 rogid:hyuYyAujJCJtbfS2tJ+UgH7jWP89606 rogid:UP21yD93ihtJxCs8xNZ3FUB94tU9606 intact-crc:B58AF288F9C81A77|rigid:/fWQJTQK1fD0fpKu4c/6K/d+bMo false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q7L5N1 uniprotkb:Q93034 intact:EBI-486838|uniprotkb:O15387|uniprotkb:A4D2A3|ensembl:ENSP00000304102 intact:EBI-1057139|uniprotkb:O14766|uniprotkb:Q9BZC6|uniprotkb:A8K960|ensembl:ENSP00000376808|ensembl:ENSP00000435376 psi-mi:csn6_human(display_long)|uniprotkb:COPS6(gene name)|psi-mi:COPS6(display_short)|uniprotkb:CSN6(gene name synonym)|uniprotkb:HVIP(gene name synonym)|uniprotkb:JAB1-containing signalosome subunit 6(gene name synonym)|uniprotkb:Vpr-interacting protein(gene name synonym)|uniprotkb:MOV34 homolog(gene name synonym) psi-mi:cul5_human(display_long)|uniprotkb:CUL5(gene name)|psi-mi:CUL5(display_short)|uniprotkb:VACM1(gene name synonym)|uniprotkb:Vasopressin-activated calcium-mobilizing receptor 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510262|imex:IM-12079-3 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006824.2|ensembl:ENSG00000168090(gene)|ensembl:ENST00000303904(transcript)|go:"GO:0000338"(protein deneddylation)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070122"(isopeptidase activity)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR033859|interpro:IPR024969|interpro:IPR037518|mint:Q7L5N1|rcsb pdb:4D10|rcsb pdb:4D18|rcsb pdb:4QFT|rcsb pdb:4R14|rcsb pdb:4WSN|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|reactome:R-HSA-5696394|reactome:R-HSA-6781823|reactome:R-HSA-8856825|reactome:R-HSA-8951664|dip:DIP-32655N refseq:NP_003469.2|ensembl:ENSG00000166266(gene)|ensembl:ENST00000393094(transcript)|ensembl:ENST00000531427(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005829"(cytosol)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031466"(Cul5-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0038128"(ERBB2 signaling pathway)|go:"GO:0090734"(site of DNA damage)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|interpro:IPR001373(Cullin, N-terminal region)|interpro:IPR016157(Cullin, conserved site)|interpro:IPR016158(Cullin homology)|interpro:IPR016159(Cullin repeat-like)|interpro:IPR019559|interpro:IPR036317|interpro:IPR036388|interpro:IPR036390|mint:Q93034|rcsb pdb:3DPL|rcsb pdb:3DQV|rcsb pdb:4JGH|rcsb pdb:4N9F|rcsb pdb:6V9I|reactome:R-HSA-180585|reactome:R-HSA-8863795|reactome:R-HSA-8951664|reactome:R-HSA-9705462|reactome:R-HSA-983168|dip:DIP-43696N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2020/10/21 rogid:hyuYyAujJCJtbfS2tJ+UgH7jWP89606 rogid:rmqOrKvxsALWuSvEcrPXxtNrcpc9606 intact-crc:B58AF288F9C81A77|rigid:/fWQJTQK1fD0fpKu4c/6K/d+bMo false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q14694 uniprotkb:Q92879 intact:EBI-2510389|uniprotkb:B4DS84|uniprotkb:B2RDJ8|uniprotkb:Q9BWG7|uniprotkb:Q9NSL7|ensembl:ENSP00000219473 intact:EBI-713032|ensembl:ENSP00000351409|uniprotkb:Q4LE52|uniprotkb:Q9NP83|uniprotkb:Q9NR06|uniprotkb:D3DQS0|uniprotkb:B4E2U5|uniprotkb:F8W940 psi-mi:ubp10_human(display_long)|uniprotkb:USP10(gene name)|psi-mi:USP10(display_short)|uniprotkb:KIAA0190(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 10(gene name synonym)|uniprotkb:Deubiquitinating enzyme 10(gene name synonym)|uniprotkb:Ubiquitin thioesterase 10(gene name synonym) psi-mi:celf1_human(display_long)|uniprotkb:Bruno-like protein 2(gene name synonym)|uniprotkb:RNA-binding protein BRUNOL-2(gene name synonym)|uniprotkb:CUG triplet repeat RNA-binding protein 1(gene name synonym)|uniprotkb:Deadenylation factor CUG-BP(gene name synonym)|uniprotkb:50 kDa nuclear polyadenylated RNA-binding protein(gene name synonym)|uniprotkb:Embryo deadenylation element-binding protein homolog(gene name synonym)|uniprotkb:CELF1(gene name)|psi-mi:CELF1(display_short)|uniprotkb:BRUNOL2(gene name synonym)|uniprotkb:CUGBP(gene name synonym)|uniprotkb:NAB50(gene name synonym)|uniprotkb:CUGBP1(gene name synonym)|uniprotkb:CUG-BP- and ETR-3-like factor 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510387|imex:IM-12079-54 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005144.2|ensembl:ENSP00000219473|ensembl:ENST00000570191|ensembl:ENSP00000457411|refseq:NP_001259004.1|ensembl:ENSG00000103194(gene)|ensembl:ENST00000219473(transcript)|go:"GO:0002039"(p53 binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006914"(autophagy)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019985"(translesion synthesis)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0071347"(cellular response to interleukin-1)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR009818(Ataxin-2, C-terminal)|interpro:IPR018200|interpro:IPR028767|interpro:IPR028889|interpro:IPR038765|mint:Q14694|reactome:R-HSA-5656169|reactome:R-HSA-5689880|go:"GO:0005737"(cytoplasm) ensembl:ENSG00000149187(gene)|ensembl:ENST00000358597(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000900"(translation repressor activity, mRNA regulatory element binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006376"(mRNA splice site selection)|go:"GO:0006397"(mRNA processing)|go:"GO:0007281"(germ cell development)|go:"GO:0007286"(spermatid development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0097356"(perinucleolar compartment)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034196|interpro:IPR034198|interpro:IPR034199|interpro:IPR035979|mint:Q92879|rcsb pdb:2CPZ|rcsb pdb:2DHS|rcsb pdb:2RQ4|rcsb pdb:2RQC|rcsb pdb:3NMR|rcsb pdb:3NNA|rcsb pdb:3NNC|go:"GO:0016020"(membrane)|rcsb pdb:3NNH|go:"GO:0016246"(RNA interference)|go:"GO:0016441"(posttranscriptional gene silencing)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0036002"(pre-mRNA binding)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042835"(BRE binding)|go:"GO:0043484"(regulation of RNA splicing)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0061157"(mRNA destabilization)|refseq:XP_011518161.1|refseq:NP_001020767.1|refseq:NP_001166110.1|refseq:NP_001166111.1|refseq:NP_006551.1|refseq:NP_941989.1|ensembl:ENST00000310513|ensembl:ENSP00000308386|ensembl:ENSP00000351409|ensembl:ENST00000361904|ensembl:ENSP00000354639|ensembl:ENST00000395290|ensembl:ENSP00000378705|ensembl:ENST00000395292|ensembl:ENSP00000378706|ensembl:ENST00000532048|ensembl:ENSP00000435926|refseq:XP_016872613.1|refseq:XP_016872614.1|refseq:XP_016872615.1|refseq:XP_016872616.1|refseq:XP_016872617.1|refseq:XP_016872618.1|refseq:XP_016872619.1|refseq:XP_016872620.1|refseq:XP_016872621.1|refseq:XP_016872622.1|refseq:XP_016872623.1|refseq:XP_016872624.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:W34ZdOIilLOVI8SXqCH3rOmmloo9606 rogid:MUTvmDd0BGmmliUR0FEiHnZq0v49606 intact-crc:8D1CAEBA69E79846|rigid:DplFqtwagt+MUOvV/TzD/ue2GrM false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q14694 uniprotkb:Q13283 intact:EBI-2510389|uniprotkb:B4DS84|uniprotkb:B2RDJ8|uniprotkb:Q9BWG7|uniprotkb:Q9NSL7|ensembl:ENSP00000219473 intact:EBI-1047359|intact:EBI-1384154|ensembl:ENSP00000348578|ensembl:ENSP00000377681|ensembl:ENSP00000430480|ensembl:ENSP00000502880|ensembl:ENSP00000503039|ensembl:ENSP00000503699|ensembl:ENSP00000503939|ensembl:ENSP00000504140|ensembl:ENSP00000504627|uniprotkb:Q5HYE9 psi-mi:ubp10_human(display_long)|uniprotkb:USP10(gene name)|psi-mi:USP10(display_short)|uniprotkb:KIAA0190(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 10(gene name synonym)|uniprotkb:Deubiquitinating enzyme 10(gene name synonym)|uniprotkb:Ubiquitin thioesterase 10(gene name synonym) psi-mi:g3bp1_human(display_long)|uniprotkb:G3BP1(gene name)|psi-mi:G3BP1(display_short)|uniprotkb:G3BP(gene name synonym)|uniprotkb:ATP-dependent DNA helicase VIII(gene name synonym)|uniprotkb:GAP SH3 domain-binding protein 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510387|imex:IM-12079-54 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005144.2|ensembl:ENSP00000219473|ensembl:ENST00000570191|ensembl:ENSP00000457411|refseq:NP_001259004.1|ensembl:ENSG00000103194(gene)|ensembl:ENST00000219473(transcript)|go:"GO:0002039"(p53 binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006914"(autophagy)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019985"(translesion synthesis)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0071347"(cellular response to interleukin-1)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR009818(Ataxin-2, C-terminal)|interpro:IPR018200|interpro:IPR028767|interpro:IPR028889|interpro:IPR038765|mint:Q14694|reactome:R-HSA-5656169|reactome:R-HSA-5689880|go:"GO:0005737"(cytoplasm) refseq:NP_005745.1|refseq:NP_938405.1|ensembl:ENSG00000145907(gene)|go:"GO:0003729"(mRNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0033677"(DNA/RNA helicase activity)|go:"GO:0034063"(stress granule assembly)|go:"GO:0043204"(perikaryon)|go:"GO:0045087"(innate immune response)|go:"GO:0051607"(defense response to virus)|go:"GO:0062029"(positive regulation of stress granule assembly)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR002075(Nuclear transport factor 2)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR018222|interpro:IPR032710|interpro:IPR034374|interpro:IPR034375|interpro:IPR035979|interpro:IPR039539|mint:Q13283|ensembl:ENST00000356245(transcript)|rcsb pdb:3Q90|rcsb pdb:4FCJ|rcsb pdb:4FCM|rcsb pdb:4IIA|rcsb pdb:5FW5|rcsb pdb:6TA7|ensembl:ENST00000394123(transcript)|ensembl:ENST00000522761(transcript)|ensembl:ENST00000676827(transcript)|ensembl:ENST00000676978(transcript)|ensembl:ENST00000677323(transcript)|ensembl:ENST00000678070(transcript)|ensembl:ENST00000678101(transcript)|ensembl:ENST00000678925(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|refseq:XP_006714812.1|refseq:XP_006714813.1|refseq:XP_016864411.1|refseq:XP_016864412.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:W34ZdOIilLOVI8SXqCH3rOmmloo9606 rogid:0ZRCHNVEmmtGEOASNwg3kIm2uys9606 intact-crc:8D1CAEBA69E79846|rigid:DplFqtwagt+MUOvV/TzD/ue2GrM false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q14694 uniprotkb:Q9UN86 intact:EBI-2510389|uniprotkb:B4DS84|uniprotkb:B2RDJ8|uniprotkb:Q9BWG7|uniprotkb:Q9NSL7|ensembl:ENSP00000219473 intact:EBI-1044298|uniprotkb:O60606|uniprotkb:O75149|uniprotkb:Q9UPA1|ensembl:ENSP00000352738|ensembl:ENSP00000379069|ensembl:ENSP00000503228|ensembl:ENSP00000503239|ensembl:ENSP00000503355|ensembl:ENSP00000503669|ensembl:ENSP00000503911|ensembl:ENSP00000503943|ensembl:ENSP00000504101|ensembl:ENSP00000504159|ensembl:ENSP00000504316|ensembl:ENSP00000504361|ensembl:ENSP00000504371|ensembl:ENSP00000504496|ensembl:ENSP00000504523|ensembl:ENSP00000504585|ensembl:ENSP00000504698|ensembl:ENSP00000503504|uniprotkb:A8K6X1 psi-mi:ubp10_human(display_long)|uniprotkb:USP10(gene name)|psi-mi:USP10(display_short)|uniprotkb:KIAA0190(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 10(gene name synonym)|uniprotkb:Deubiquitinating enzyme 10(gene name synonym)|uniprotkb:Ubiquitin thioesterase 10(gene name synonym) psi-mi:g3bp2_human(display_long)|uniprotkb:GAP SH3 domain-binding protein 2(gene name synonym)|uniprotkb:G3BP2(gene name)|psi-mi:G3BP2(display_short)|uniprotkb:KIAA0660(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510387|imex:IM-12079-54 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005144.2|ensembl:ENSP00000219473|ensembl:ENST00000570191|ensembl:ENSP00000457411|refseq:NP_001259004.1|ensembl:ENSG00000103194(gene)|ensembl:ENST00000219473(transcript)|go:"GO:0002039"(p53 binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006914"(autophagy)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019985"(translesion synthesis)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0071347"(cellular response to interleukin-1)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR009818(Ataxin-2, C-terminal)|interpro:IPR018200|interpro:IPR028767|interpro:IPR028889|interpro:IPR038765|mint:Q14694|reactome:R-HSA-5656169|reactome:R-HSA-5689880|go:"GO:0005737"(cytoplasm) refseq:NP_036429.2|refseq:NP_987100.1|refseq:NP_987101.1|ensembl:ENSG00000138757(gene)|ensembl:ENST00000677620(transcript)|ensembl:ENST00000678062(transcript)|ensembl:ENST00000678100(transcript)|ensembl:ENST00000678123(transcript)|ensembl:ENST00000678265(transcript)|ensembl:ENST00000678578(transcript)|ensembl:ENST00000678798(transcript)|ensembl:ENST00000678971(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007253"(cytoplasmic sequestering of NF-kappaB)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0034063"(stress granule assembly)|go:"GO:0045087"(innate immune response)|go:"GO:0051028"(mRNA transport)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0062029"(positive regulation of stress granule assembly)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR002075(Nuclear transport factor 2)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR018222|interpro:IPR032710|interpro:IPR034376|interpro:IPR034377|interpro:IPR035979|interpro:IPR039539|mint:Q9UN86|rcsb pdb:5DRV|ensembl:ENST00000359707(transcript)|ensembl:ENST00000395719(transcript)|ensembl:ENST00000676584(transcript)|ensembl:ENST00000676974(transcript)|ensembl:ENST00000677162(transcript)|ensembl:ENST00000677171(transcript)|ensembl:ENST00000677201(transcript)|ensembl:ENST00000677333(transcript)|ensembl:ENST00000677566(transcript)|ensembl:ENST00000677606(transcript)|refseq:XP_011530743.1|refseq:XP_005263439.1|refseq:XP_005263440.1|refseq:XP_016864365.1|refseq:XP_016864366.1|refseq:XP_016864367.1|refseq:XP_016864368.1|dip:DIP-50299N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:W34ZdOIilLOVI8SXqCH3rOmmloo9606 rogid:bYP8U2wviIqJBWcnLQnuoV0MhV89606 intact-crc:8D1CAEBA69E79846|rigid:DplFqtwagt+MUOvV/TzD/ue2GrM false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q14694 uniprotkb:Q4LE58 intact:EBI-2510389|uniprotkb:B4DS84|uniprotkb:B2RDJ8|uniprotkb:Q9BWG7|uniprotkb:Q9NSL7|ensembl:ENSP00000219473 intact:EBI-877750 psi-mi:ubp10_human(display_long)|uniprotkb:USP10(gene name)|psi-mi:USP10(display_short)|uniprotkb:KIAA0190(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 10(gene name synonym)|uniprotkb:Deubiquitinating enzyme 10(gene name synonym)|uniprotkb:Ubiquitin thioesterase 10(gene name synonym) psi-mi:q4le58_human(display_long)|uniprotkb:EIF4G1 variant protein(gene name)|psi-mi:EIF4G1 variant protein(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510387|imex:IM-12079-54 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005144.2|ensembl:ENSP00000219473|ensembl:ENST00000570191|ensembl:ENSP00000457411|refseq:NP_001259004.1|ensembl:ENSG00000103194(gene)|ensembl:ENST00000219473(transcript)|go:"GO:0002039"(p53 binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006914"(autophagy)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019985"(translesion synthesis)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0071347"(cellular response to interleukin-1)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR009818(Ataxin-2, C-terminal)|interpro:IPR018200|interpro:IPR028767|interpro:IPR028889|interpro:IPR038765|mint:Q14694|reactome:R-HSA-5656169|reactome:R-HSA-5689880|go:"GO:0005737"(cytoplasm) go:"GO:0003729"(mRNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0008190"(eukaryotic initiation factor 4E binding)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR003307(eIF4-gamma/eIF5/eIF2-epsilon)|interpro:IPR003891(Initiation factor eIF-4 gamma, MA3)|interpro:IPR003890(MIF4G-like, type 3)|interpro:IPR037584|interpro:IPR016021(MIF4-like, type 1/2/3) psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:W34ZdOIilLOVI8SXqCH3rOmmloo9606 rogid:Y/nGTcJwfFXWNRyAStOYrrJBojM9606 intact-crc:8D1CAEBA69E79846|rigid:DplFqtwagt+MUOvV/TzD/ue2GrM false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q14694 uniprotkb:O43432 intact:EBI-2510389|uniprotkb:B4DS84|uniprotkb:B2RDJ8|uniprotkb:Q9BWG7|uniprotkb:Q9NSL7|ensembl:ENSP00000219473 intact:EBI-464766|uniprotkb:Q5SWC3|ensembl:ENSP00000264211|uniprotkb:Q15597|uniprotkb:Q8NEN1|uniprotkb:Q504Z1|uniprotkb:B9EGQ7 psi-mi:ubp10_human(display_long)|uniprotkb:USP10(gene name)|psi-mi:USP10(display_short)|uniprotkb:KIAA0190(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 10(gene name synonym)|uniprotkb:Deubiquitinating enzyme 10(gene name synonym)|uniprotkb:Ubiquitin thioesterase 10(gene name synonym) psi-mi:if4g3_human(display_long)|uniprotkb:EIF4G3(gene name)|psi-mi:EIF4G3(display_short)|uniprotkb:eIF-4-gamma II(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510387|imex:IM-12079-54 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005144.2|ensembl:ENSP00000219473|ensembl:ENST00000570191|ensembl:ENSP00000457411|refseq:NP_001259004.1|ensembl:ENSG00000103194(gene)|ensembl:ENST00000219473(transcript)|go:"GO:0002039"(p53 binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006914"(autophagy)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019985"(translesion synthesis)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0071347"(cellular response to interleukin-1)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR009818(Ataxin-2, C-terminal)|interpro:IPR018200|interpro:IPR028767|interpro:IPR028889|interpro:IPR038765|mint:Q14694|reactome:R-HSA-5656169|reactome:R-HSA-5689880|go:"GO:0005737"(cytoplasm) ensembl:ENST00000264211(transcript)|go:"GO:0000339"(RNA cap binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0008135"(translation factor activity, RNA binding)|go:"GO:0016281"(eukaryotic translation initiation factor 4F complex)|interpro:IPR003307(eIF4-gamma/eIF5/eIF2-epsilon)|interpro:IPR003890(MIF4G-like, type 3)|interpro:IPR003891(Initiation factor eIF-4 gamma, MA3)|interpro:IPR016021(MIF4-like, type 1/2/3)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR037585|mint:O43432|rcsb pdb:1HU3|reactome:R-HSA-1169408|ensembl:ENSG00000075151(gene)|refseq:NP_001185732.1|refseq:NP_003751.2|ensembl:ENSP00000264211|ensembl:ENST00000356916|ensembl:ENSP00000349386|ensembl:ENST00000374935|ensembl:ENSP00000364071|ensembl:ENST00000602326|ensembl:ENSP00000473510|ensembl:ENST00000682284|ensembl:ENSP00000507819|refseq:NP_001185731.1|refseq:NP_001185730.1|refseq:XP_016858189.1|refseq:XP_016858197.1|refseq:XP_016858201.1|dip:DIP-33245N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:W34ZdOIilLOVI8SXqCH3rOmmloo9606 rogid:dN5046U5kz1WfBJD0+NWYMMU6RY9606 intact-crc:8D1CAEBA69E79846|rigid:DplFqtwagt+MUOvV/TzD/ue2GrM false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q14694 uniprotkb:Q9NY12 intact:EBI-2510389|uniprotkb:B4DS84|uniprotkb:B2RDJ8|uniprotkb:Q9BWG7|uniprotkb:Q9NSL7|ensembl:ENSP00000219473 intact:EBI-2510382|ensembl:ENSP00000226796|ensembl:ENSP00000378127|uniprotkb:Q5MJQ2 psi-mi:ubp10_human(display_long)|uniprotkb:USP10(gene name)|psi-mi:USP10(display_short)|uniprotkb:KIAA0190(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 10(gene name synonym)|uniprotkb:Deubiquitinating enzyme 10(gene name synonym)|uniprotkb:Ubiquitin thioesterase 10(gene name synonym) psi-mi:gar1_human(display_long)|uniprotkb:GAR1(gene name)|psi-mi:GAR1(display_short)|uniprotkb:NOLA1(gene name synonym)|uniprotkb:snoRNP protein GAR1(gene name synonym)|uniprotkb:Nucleolar protein family A member 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510387|imex:IM-12079-54 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005144.2|ensembl:ENSP00000219473|ensembl:ENST00000570191|ensembl:ENSP00000457411|refseq:NP_001259004.1|ensembl:ENSG00000103194(gene)|ensembl:ENST00000219473(transcript)|go:"GO:0002039"(p53 binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006914"(autophagy)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019985"(translesion synthesis)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0071347"(cellular response to interleukin-1)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR009818(Ataxin-2, C-terminal)|interpro:IPR018200|interpro:IPR028767|interpro:IPR028889|interpro:IPR038765|mint:Q14694|reactome:R-HSA-5656169|reactome:R-HSA-5689880|go:"GO:0005737"(cytoplasm) ensembl:ENSG00000109534(gene)|ensembl:ENST00000226796(transcript)|ensembl:ENST00000394631(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0031429"(box H/ACA snoRNP complex)|go:"GO:0034513"(box H/ACA snoRNA binding)|go:"GO:0070034"(telomerase RNA binding)|go:"GO:0072589"(box H/ACA scaRNP complex)|go:"GO:0090661"(box H/ACA telomerase RNP complex)|interpro:IPR007504(Gar1 protein RNA-binding region)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)|interpro:IPR038664|mint:Q9NY12|rcsb pdb:7BGB|reactome:R-HSA-171319|go:"GO:0000454"(snoRNA guided rRNA pseudouridine synthesis)|reactome:R-HSA-6790901|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|refseq:NP_061856.1|refseq:NP_127460.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:W34ZdOIilLOVI8SXqCH3rOmmloo9606 rogid:voLJvYfWyMWtTf0VSd7XeY3psC09606 intact-crc:8D1CAEBA69E79846|rigid:DplFqtwagt+MUOvV/TzD/ue2GrM false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9NQC7 uniprotkb:Q8TEP8 intact:EBI-2117940|uniprotkb:O94934|uniprotkb:Q7L3N6|uniprotkb:Q96EH0|uniprotkb:Q9NZX9|ensembl:ENSP00000308928|ensembl:ENSP00000392025 intact:EBI-2339778|uniprotkb:Q9H0F4|uniprotkb:Q8WYT8|uniprotkb:Q9NW27|uniprotkb:A0A060A9S4|intact:EBI-11329707|uniprotkb:B7ZMF0|uniprotkb:E9PF99|intact:EBI-10984660|ensembl:ENSP00000427550 psi-mi:cyld_human(display_long)|uniprotkb:Ubiquitin thioesterase CYLD(gene name synonym)|uniprotkb:CYLD(gene name)|psi-mi:CYLD(display_short)|uniprotkb:CYLD1(gene name synonym)|uniprotkb:KIAA0849(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease CYLD(gene name synonym)|uniprotkb:Deubiquitinating enzyme CYLD(gene name synonym)|uniprotkb:HSPC057(orf name) psi-mi:ce192_human(display_long)|uniprotkb:CEP192(gene name)|psi-mi:CEP192(display_short)|uniprotkb:KIAA1569(gene name synonym)|uniprotkb:PP8407(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510419|imex:IM-12079-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001035814.1|refseq:NP_001035877.1|refseq:NP_056062.1|refseq:XP_016878467.1|refseq:XP_016878469.1|go:"GO:0007049"(cell cycle)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010803"(regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0005874"(microtubule)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032480"(negative regulation of type I interferon production)|go:"GO:0036064"(ciliary basal body)|go:"GO:0045087"(innate immune response)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0060544"(regulation of necroptotic process)|go:"GO:0061578"(Lys63-specific deubiquitinase activity)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0070266"(necroptotic process)|go:"GO:0070423"(nucleotide-binding oligomerization domain containing signaling pathway)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097542"(ciliary tip)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1902017"(regulation of cilium assembly)|go:"GO:1903753"(negative regulation of p38MAPK cascade)|go:"GO:1990108"(protein linear deubiquitination)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001242"(regulation of intrinsic apoptotic signaling pathway)|interpro:IPR000938(Cytoskeleton-associated protein, CAP-Gly)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR036859|interpro:IPR038765|mint:Q9NQC7|rcsb pdb:1IXD|rcsb pdb:1WHL|rcsb pdb:1WHM|rcsb pdb:2VHF|reactome:R-HSA-168638|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5689880|reactome:R-HSA-936440|ensembl:ENSG00000083799(gene)|ensembl:ENST00000311559(transcript)|ensembl:ENST00000427738(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|refseq:XP_005255869.1|refseq:XP_006721212.1|refseq:XP_011521209.1|refseq:XP_016878466.1|refseq:XP_016878468.1 refseq:NP_115518.3|dip:DIP-52779N|ensembl:ENSG00000101639(gene)|ensembl:ENST00000506447(transcript)|go:"GO:0000242"(pericentriolar material)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0007099"(centriole replication)|go:"GO:0009617"(response to bacterium)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0071539"(protein localization to centrosome)|go:"GO:0090222"(centrosome-templated microtubule nucleation)|go:"GO:0090307"(mitotic spindle assembly)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR039103|rcsb pdb:4N7Z|rcsb pdb:6FVI|rcsb pdb:6W3J|reactome:R-HSA-2565942|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-8854518 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/07/23 rogid:Z01woAwtDVaoNnAthw9tTrBqRao9606 rogid:XXxzXD9dfRTtgx/tKR0VhGAlPWc9606 intact-crc:2C86053894F99559|rigid:nKeSsxUnTHkXXXlVglUynlXxejY false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9NQC7 uniprotkb:Q9UM54 intact:EBI-2117940|uniprotkb:O94934|uniprotkb:Q7L3N6|uniprotkb:Q96EH0|uniprotkb:Q9NZX9|ensembl:ENSP00000308928|ensembl:ENSP00000392025 intact:EBI-350606|uniprotkb:Q5TEM5|uniprotkb:Q5TEM6|uniprotkb:Q5TEM7|uniprotkb:Q9BZZ7|uniprotkb:Q9UEG2|uniprotkb:A6H8V4|uniprotkb:E1P540 psi-mi:cyld_human(display_long)|uniprotkb:Ubiquitin thioesterase CYLD(gene name synonym)|uniprotkb:CYLD(gene name)|psi-mi:CYLD(display_short)|uniprotkb:CYLD1(gene name synonym)|uniprotkb:KIAA0849(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease CYLD(gene name synonym)|uniprotkb:Deubiquitinating enzyme CYLD(gene name synonym)|uniprotkb:HSPC057(orf name) psi-mi:myo6_human(display_long)|uniprotkb:MYO6(gene name)|psi-mi:MYO6(display_short)|uniprotkb:KIAA0389(gene name synonym)|uniprotkb:Unconventional myosin-6(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510419|imex:IM-12079-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001035814.1|refseq:NP_001035877.1|refseq:NP_056062.1|refseq:XP_016878467.1|refseq:XP_016878469.1|go:"GO:0007049"(cell cycle)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010803"(regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0005874"(microtubule)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032480"(negative regulation of type I interferon production)|go:"GO:0036064"(ciliary basal body)|go:"GO:0045087"(innate immune response)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0060544"(regulation of necroptotic process)|go:"GO:0061578"(Lys63-specific deubiquitinase activity)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0070266"(necroptotic process)|go:"GO:0070423"(nucleotide-binding oligomerization domain containing signaling pathway)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097542"(ciliary tip)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1902017"(regulation of cilium assembly)|go:"GO:1903753"(negative regulation of p38MAPK cascade)|go:"GO:1990108"(protein linear deubiquitination)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001242"(regulation of intrinsic apoptotic signaling pathway)|interpro:IPR000938(Cytoskeleton-associated protein, CAP-Gly)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR036859|interpro:IPR038765|mint:Q9NQC7|rcsb pdb:1IXD|rcsb pdb:1WHL|rcsb pdb:1WHM|rcsb pdb:2VHF|reactome:R-HSA-168638|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5689880|reactome:R-HSA-936440|ensembl:ENSG00000083799(gene)|ensembl:ENST00000311559(transcript)|ensembl:ENST00000427738(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|refseq:XP_005255869.1|refseq:XP_006721212.1|refseq:XP_011521209.1|refseq:XP_016878466.1|refseq:XP_016878468.1 go:"GO:0051046"(regulation of secretion)|refseq:NP_004990.3|go:"GO:0000146"(microfilament motor activity)|go:"GO:0001726"(ruffle)|go:"GO:0003774"(cytoskeletal motor activity)|go:"GO:0003779"(actin binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016461"(unconventional myosin complex)|go:"GO:0016591"(RNA polymerase II, holoenzyme)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0030050"(vesicle transport along actin filament)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030175"(filopodium)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0030665"(clathrin-coated vesicle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031941"(filamentous actin)|go:"GO:0031965"(nuclear membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032587"(ruffle membrane)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043531"(ADP binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051015"(actin filament binding)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005938"(cell cortex)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006897"(endocytosis)|go:"GO:0007015"(actin filament organization)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001609(Myosin head, motor region)|interpro:IPR004009(Myosin, N-terminal, SH3-like)|interpro:IPR008989(Myosin S1 fragment, N-terminal)|interpro:IPR027417|interpro:IPR032412|interpro:IPR036114|interpro:IPR036961|rcsb pdb:2N0Z|rcsb pdb:2N10|rcsb pdb:2N11|go:"GO:0060001"(minus-end directed microfilament motor activity)|rcsb pdb:2N12|rcsb pdb:2N13|rcsb pdb:6E5N|rcsb pdb:6J56|reactome:R-HSA-190873|reactome:R-HSA-399719|reactome:R-HSA-9013418|reactome:R-HSA-9013420|reactome:R-HSA-9013422|refseq:NP_001287828.1|mint:Q9UM54|dip:DIP-33123N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/07/23 rogid:Z01woAwtDVaoNnAthw9tTrBqRao9606 rogid:LYtnU7aRzVE/LDFhZgcK5IvahC09606 intact-crc:2C86053894F99559|rigid:nKeSsxUnTHkXXXlVglUynlXxejY false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9NQC7 uniprotkb:Q8IUW3 intact:EBI-2117940|uniprotkb:O94934|uniprotkb:Q7L3N6|uniprotkb:Q96EH0|uniprotkb:Q9NZX9|ensembl:ENSP00000308928|ensembl:ENSP00000392025 intact:EBI-2510414|ensembl:ENSP00000289805|uniprotkb:Q8NHV3|uniprotkb:D3DX85 psi-mi:cyld_human(display_long)|uniprotkb:Ubiquitin thioesterase CYLD(gene name synonym)|uniprotkb:CYLD(gene name)|psi-mi:CYLD(display_short)|uniprotkb:CYLD1(gene name synonym)|uniprotkb:KIAA0849(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease CYLD(gene name synonym)|uniprotkb:Deubiquitinating enzyme CYLD(gene name synonym)|uniprotkb:HSPC057(orf name) psi-mi:spa2l_human(display_long)|uniprotkb:SPATA2L(gene name)|psi-mi:SPATA2L(display_short)|uniprotkb:C16orf76(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510419|imex:IM-12079-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001035814.1|refseq:NP_001035877.1|refseq:NP_056062.1|refseq:XP_016878467.1|refseq:XP_016878469.1|go:"GO:0007049"(cell cycle)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010803"(regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0005874"(microtubule)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032480"(negative regulation of type I interferon production)|go:"GO:0036064"(ciliary basal body)|go:"GO:0045087"(innate immune response)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0060544"(regulation of necroptotic process)|go:"GO:0061578"(Lys63-specific deubiquitinase activity)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0070266"(necroptotic process)|go:"GO:0070423"(nucleotide-binding oligomerization domain containing signaling pathway)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097542"(ciliary tip)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1902017"(regulation of cilium assembly)|go:"GO:1903753"(negative regulation of p38MAPK cascade)|go:"GO:1990108"(protein linear deubiquitination)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001242"(regulation of intrinsic apoptotic signaling pathway)|interpro:IPR000938(Cytoskeleton-associated protein, CAP-Gly)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR036859|interpro:IPR038765|mint:Q9NQC7|rcsb pdb:1IXD|rcsb pdb:1WHL|rcsb pdb:1WHM|rcsb pdb:2VHF|reactome:R-HSA-168638|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5689880|reactome:R-HSA-936440|ensembl:ENSG00000083799(gene)|ensembl:ENST00000311559(transcript)|ensembl:ENST00000427738(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|refseq:XP_005255869.1|refseq:XP_006721212.1|refseq:XP_011521209.1|refseq:XP_016878466.1|refseq:XP_016878468.1 ensembl:ENSG00000158792(gene)|ensembl:ENST00000289805(transcript)|go:"GO:0005737"(cytoplasm)|interpro:IPR029745|refseq:NP_689552.2|refseq:XP_005256336.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/07/23 rogid:Z01woAwtDVaoNnAthw9tTrBqRao9606 rogid:T+j7MmE5wRkSdglyvWC5iuDvfbU9606 intact-crc:2C86053894F99559|rigid:nKeSsxUnTHkXXXlVglUynlXxejY false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9NQC7 uniprotkb:Q13557 intact:EBI-2117940|uniprotkb:O94934|uniprotkb:Q7L3N6|uniprotkb:Q96EH0|uniprotkb:Q9NZX9|ensembl:ENSP00000308928|ensembl:ENSP00000392025 intact:EBI-351018|intact:EBI-1642546|uniprotkb:Q52PK4|uniprotkb:Q59G21|uniprotkb:Q8N553|uniprotkb:Q9UGH6|uniprotkb:Q9UQE9|uniprotkb:A8MVS8|ensembl:ENSP00000339740|ensembl:ENSP00000507073 psi-mi:cyld_human(display_long)|uniprotkb:Ubiquitin thioesterase CYLD(gene name synonym)|uniprotkb:CYLD(gene name)|psi-mi:CYLD(display_short)|uniprotkb:CYLD1(gene name synonym)|uniprotkb:KIAA0849(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease CYLD(gene name synonym)|uniprotkb:Deubiquitinating enzyme CYLD(gene name synonym)|uniprotkb:HSPC057(orf name) psi-mi:kcc2d_human(display_long)|uniprotkb:CAMK2D(gene name)|psi-mi:CAMK2D(display_short)|uniprotkb:CAMKD(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510419|imex:IM-12079-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001035814.1|refseq:NP_001035877.1|refseq:NP_056062.1|refseq:XP_016878467.1|refseq:XP_016878469.1|go:"GO:0007049"(cell cycle)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010803"(regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0005874"(microtubule)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032480"(negative regulation of type I interferon production)|go:"GO:0036064"(ciliary basal body)|go:"GO:0045087"(innate immune response)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0060544"(regulation of necroptotic process)|go:"GO:0061578"(Lys63-specific deubiquitinase activity)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0070266"(necroptotic process)|go:"GO:0070423"(nucleotide-binding oligomerization domain containing signaling pathway)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097542"(ciliary tip)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1902017"(regulation of cilium assembly)|go:"GO:1903753"(negative regulation of p38MAPK cascade)|go:"GO:1990108"(protein linear deubiquitination)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001242"(regulation of intrinsic apoptotic signaling pathway)|interpro:IPR000938(Cytoskeleton-associated protein, CAP-Gly)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR036859|interpro:IPR038765|mint:Q9NQC7|rcsb pdb:1IXD|rcsb pdb:1WHL|rcsb pdb:1WHM|rcsb pdb:2VHF|reactome:R-HSA-168638|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5689880|reactome:R-HSA-936440|ensembl:ENSG00000083799(gene)|ensembl:ENST00000311559(transcript)|ensembl:ENST00000427738(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|refseq:XP_005255869.1|refseq:XP_006721212.1|refseq:XP_011521209.1|refseq:XP_016878466.1|refseq:XP_016878468.1 refseq:NP_001212.2|refseq:NP_742112.1|refseq:NP_742113.1|refseq:NP_742125.1|refseq:NP_742126.1|refseq:NP_742127.1|refseq:NP_001308495.1|refseq:NP_001308502.1|refseq:NP_001308509.1|refseq:NP_001308518.1|ensembl:ENSG00000145349(gene)|ensembl:ENST00000342666(transcript)|ensembl:ENST00000683023(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0003254"(regulation of membrane depolarization)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005954"(calcium- and calmodulin-dependent protein kinase complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008016"(regulation of heart contraction)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0010649"(regulation of cell communication by electrical coupling)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0010880"(regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0016020"(membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019871"(sodium channel inhibitor activity)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031432"(titin binding)|go:"GO:0032469"(endoplasmic reticulum calcium ion homeostasis)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0055119"(relaxation of cardiac muscle)|go:"GO:0060314"(regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0060341"(regulation of cellular localization)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0086003"(cardiac muscle cell contraction)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0098901"(regulation of cardiac muscle cell action potential)|go:"GO:0098909"(regulation of cardiac muscle cell action potential involved in regulation of contraction)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901725"(regulation of histone deacetylase activity)|go:"GO:1901844"(regulation of cell communication by electrical coupling involved in cardiac conduction)|go:"GO:1901897"(regulation of relaxation of cardiac muscle)|go:"GO:1902306"(negative regulation of sodium ion transmembrane transport)|go:"GO:1902514"(regulation of calcium ion transmembrane transport via high voltage-gated calcium channel)|go:"GO:2000650"(negative regulation of sodium ion transmembrane transporter activity)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013543(Calcium/calmodulin dependent protein kinase II, association-domain)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q13557|rcsb pdb:2VN9|rcsb pdb:2W2C|rcsb pdb:2WEL|rcsb pdb:3GP2|rcsb pdb:5VLO|rcsb pdb:6AYW|reactome:R-HSA-111932|reactome:R-HSA-3371571|reactome:R-HSA-399719|reactome:R-HSA-438066|reactome:R-HSA-442982|reactome:R-HSA-5576892|reactome:R-HSA-5578775|reactome:R-HSA-5673000|reactome:R-HSA-5673001|reactome:R-HSA-6802946|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-877300|reactome:R-HSA-9022692|reactome:R-HSA-936837|reactome:R-HSA-9609736|reactome:R-HSA-9617324|reactome:R-HSA-9620244|reactome:R-HSA-9649948|reactome:R-HSA-9656223|interpro:IPR032710|refseq:XP_011530591.1|refseq:XP_011530593.1|dip:DIP-33129N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/07/23 rogid:Z01woAwtDVaoNnAthw9tTrBqRao9606 rogid:z2mz73Kq9gwpKgo2Todn0IxQpSI9606 intact-crc:2C86053894F99559|rigid:nKeSsxUnTHkXXXlVglUynlXxejY false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9NQC7 uniprotkb:Q9UM82 intact:EBI-2117940|uniprotkb:O94934|uniprotkb:Q7L3N6|uniprotkb:Q96EH0|uniprotkb:Q9NZX9|ensembl:ENSP00000308928|ensembl:ENSP00000392025 intact:EBI-744066|uniprotkb:O94857|uniprotkb:E1P626|ensembl:ENSP00000289431|ensembl:ENSP00000416799 psi-mi:cyld_human(display_long)|uniprotkb:Ubiquitin thioesterase CYLD(gene name synonym)|uniprotkb:CYLD(gene name)|psi-mi:CYLD(display_short)|uniprotkb:CYLD1(gene name synonym)|uniprotkb:KIAA0849(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease CYLD(gene name synonym)|uniprotkb:Deubiquitinating enzyme CYLD(gene name synonym)|uniprotkb:HSPC057(orf name) psi-mi:spat2_human(display_long)|uniprotkb:SPATA2(gene name)|psi-mi:SPATA2(display_short)|uniprotkb:KIAA0757(gene name synonym)|uniprotkb:PD1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510419|imex:IM-12079-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001035814.1|refseq:NP_001035877.1|refseq:NP_056062.1|refseq:XP_016878467.1|refseq:XP_016878469.1|go:"GO:0007049"(cell cycle)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010803"(regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0005874"(microtubule)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032480"(negative regulation of type I interferon production)|go:"GO:0036064"(ciliary basal body)|go:"GO:0045087"(innate immune response)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0060544"(regulation of necroptotic process)|go:"GO:0061578"(Lys63-specific deubiquitinase activity)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0070266"(necroptotic process)|go:"GO:0070423"(nucleotide-binding oligomerization domain containing signaling pathway)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097542"(ciliary tip)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1902017"(regulation of cilium assembly)|go:"GO:1903753"(negative regulation of p38MAPK cascade)|go:"GO:1990108"(protein linear deubiquitination)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001242"(regulation of intrinsic apoptotic signaling pathway)|interpro:IPR000938(Cytoskeleton-associated protein, CAP-Gly)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR036859|interpro:IPR038765|mint:Q9NQC7|rcsb pdb:1IXD|rcsb pdb:1WHL|rcsb pdb:1WHM|rcsb pdb:2VHF|reactome:R-HSA-168638|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5689880|reactome:R-HSA-936440|ensembl:ENSG00000083799(gene)|ensembl:ENST00000311559(transcript)|ensembl:ENST00000427738(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|refseq:XP_005255869.1|refseq:XP_006721212.1|refseq:XP_011521209.1|refseq:XP_016878466.1|refseq:XP_016878468.1 refseq:NP_001129245.1|refseq:NP_006029.1|refseq:XP_011527418.1|ensembl:ENSG00000158480(gene)|ensembl:ENST00000289431(transcript)|ensembl:ENST00000422556(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0007283"(spermatogenesis)|go:"GO:0010803"(regulation of tumor necrosis factor-mediated signaling pathway)|refseq:XP_006723957.1|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0060544"(regulation of necroptotic process)|go:"GO:0070266"(necroptotic process)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0072520"(seminiferous tubule development)|go:"GO:1990108"(protein linear deubiquitination)|go:"GO:1990381"(ubiquitin-specific protease binding)|interpro:IPR029744|mint:Q9UM82|rcsb pdb:5LJM|rcsb pdb:5LJN psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/07/23 rogid:Z01woAwtDVaoNnAthw9tTrBqRao9606 rogid:VwbVhr/GuqylbroxXXcpBpWAXvM9606 intact-crc:2C86053894F99559|rigid:nKeSsxUnTHkXXXlVglUynlXxejY false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9NQC7 uniprotkb:O60502 intact:EBI-2117940|uniprotkb:O94934|uniprotkb:Q7L3N6|uniprotkb:Q96EH0|uniprotkb:Q9NZX9|ensembl:ENSP00000308928|ensembl:ENSP00000392025 intact:EBI-715814|uniprotkb:O75166|uniprotkb:Q86WV0|uniprotkb:Q8IV98|uniprotkb:Q9BVA5|uniprotkb:Q9HAR0|uniprotkb:B7WPB9|uniprotkb:D3DR79|uniprotkb:E9PGF9|ensembl:ENSP00000354850 psi-mi:cyld_human(display_long)|uniprotkb:Ubiquitin thioesterase CYLD(gene name synonym)|uniprotkb:CYLD(gene name)|psi-mi:CYLD(display_short)|uniprotkb:CYLD1(gene name synonym)|uniprotkb:KIAA0849(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease CYLD(gene name synonym)|uniprotkb:Deubiquitinating enzyme CYLD(gene name synonym)|uniprotkb:HSPC057(orf name) psi-mi:oga_human(display_long)|uniprotkb:OGA(gene name)|psi-mi:OGA(display_short)|uniprotkb:Beta-N-acetylglucosaminidase(gene name synonym)|uniprotkb:Beta-N-acetylhexosaminidase(gene name synonym)|uniprotkb:Beta-hexosaminidase(gene name synonym)|uniprotkb:HEXC(gene name synonym)|uniprotkb:KIAA0679(gene name synonym)|uniprotkb:MEA5(gene name synonym)|uniprotkb:MGEA5(gene name synonym)|uniprotkb:Meningioma-expressed antigen 5(gene name synonym)|uniprotkb:N-acetyl-beta-D-glucosaminidase(gene name synonym)|uniprotkb:N-acetyl-beta-glucosaminidase(gene name synonym)|uniprotkb:Nuclear cytoplasmic O-GlcNAcase and acetyltransferase(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510419|imex:IM-12079-4 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001035814.1|refseq:NP_001035877.1|refseq:NP_056062.1|refseq:XP_016878467.1|refseq:XP_016878469.1|go:"GO:0007049"(cell cycle)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010803"(regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0005874"(microtubule)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032480"(negative regulation of type I interferon production)|go:"GO:0036064"(ciliary basal body)|go:"GO:0045087"(innate immune response)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0060544"(regulation of necroptotic process)|go:"GO:0061578"(Lys63-specific deubiquitinase activity)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0070266"(necroptotic process)|go:"GO:0070423"(nucleotide-binding oligomerization domain containing signaling pathway)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097542"(ciliary tip)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1902017"(regulation of cilium assembly)|go:"GO:1903753"(negative regulation of p38MAPK cascade)|go:"GO:1990108"(protein linear deubiquitination)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001242"(regulation of intrinsic apoptotic signaling pathway)|interpro:IPR000938(Cytoskeleton-associated protein, CAP-Gly)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR036859|interpro:IPR038765|mint:Q9NQC7|rcsb pdb:1IXD|rcsb pdb:1WHL|rcsb pdb:1WHM|rcsb pdb:2VHF|reactome:R-HSA-168638|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5689880|reactome:R-HSA-936440|ensembl:ENSG00000083799(gene)|ensembl:ENST00000311559(transcript)|ensembl:ENST00000427738(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|refseq:XP_005255869.1|refseq:XP_006721212.1|refseq:XP_011521209.1|refseq:XP_016878466.1|refseq:XP_016878468.1 refseq:NP_001135906.1|refseq:NP_036347.1|ensembl:ENSG00000198408(gene)|ensembl:ENST00000361464(transcript)|go:"GO:0004415"(hyalurononglucosaminidase activity)|go:"GO:0005829"(cytosol)|go:"GO:0006044"(N-acetylglucosamine metabolic process)|go:"GO:0006493"(protein O-linked glycosylation)|go:"GO:0006516"(glycoprotein catabolic process)|go:"GO:0006517"(protein deglycosylation)|go:"GO:0009100"(glycoprotein metabolic process)|go:"GO:0016020"(membrane)|go:"GO:0016231"(beta-N-acetylglucosaminidase activity)|go:"GO:0102166"("[protein]-3-O-(N-acetyl-D-glucosaminyl)-L-threonine O-N-acetyl-alpha-D-glucosaminase activity")|go:"GO:0102167"("[protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine O-N-acetyl-alpha-D-glucosaminase activity")|go:"GO:0102571"("[protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine/L-threonine O-N-acetyl-alpha-D-glucosaminase activity")|interpro:IPR011496(Hyaluronidase eukaryotic/prokaryotic)|interpro:IPR016181(Acyl-CoA N-acyltransferase)|interpro:IPR017853(Glycoside hydrolase, catalytic core)|rcsb pdb:2YDQ|rcsb pdb:5M7R|rcsb pdb:5M7S|rcsb pdb:5M7T|rcsb pdb:5M7U|rcsb pdb:5TKE|rcsb pdb:5UHK|rcsb pdb:5UHL|rcsb pdb:5UHO|rcsb pdb:5UHP|rcsb pdb:5UN8|rcsb pdb:5UN9|rcsb pdb:5VVO|rcsb pdb:5VVT|rcsb pdb:5VVU|rcsb pdb:5VVV|rcsb pdb:5VVX|rcsb pdb:6HKI|rcsb pdb:6PM9|go:"GO:0005634"(nucleus) psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/07/23 rogid:Z01woAwtDVaoNnAthw9tTrBqRao9606 rogid:KEvP6+2BWwsxrs8hsIjQhKAQGVo9606 intact-crc:2C86053894F99559|rigid:nKeSsxUnTHkXXXlVglUynlXxejY false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O15372 uniprotkb:O14514 intact:EBI-709735|ensembl:ENSP00000429931 intact:EBI-1995178|ensembl:ENSP00000313046|ensembl:ENSP00000430945 psi-mi:eif3h_human(display_long)|uniprotkb:EIF3S3(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 3(gene name synonym)|uniprotkb:eIF-3-gamma(gene name synonym)|uniprotkb:eIF3 p40 subunit(gene name synonym)|uniprotkb:EIF3H(gene name)|psi-mi:EIF3H(display_short) psi-mi:agrb1_human(display_long)|uniprotkb:ADGRB1(gene name)|psi-mi:ADGRB1(display_short)|uniprotkb:BAI1(gene name synonym)|uniprotkb:Brain-specific angiogenesis inhibitor 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510472|imex:IM-12079-55 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003747.1|ensembl:ENSG00000147677(gene)|ensembl:ENST00000521861(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070122"(isopeptidase activity)|go:"GO:0071541"(eukaryotic translation initiation factor 3 complex, eIF3m)|go:"GO:0101005"(deubiquitinase activity)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR027524|interpro:IPR037518|mint:O15372|rcsb pdb:3J8B|rcsb pdb:3J8C|rcsb pdb:6YBD|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|dip:DIP-33689N refseq:XP_011515501.1|refseq:NP_001693.2|dip:DIP-40884N|ensembl:ENSG00000181790(gene)|ensembl:ENST00000323289(transcript)|ensembl:ENST00000517894(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001891"(phagocytic cup)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006910"(phagocytosis, recognition)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007409"(axonogenesis)|go:"GO:0007422"(peripheral nervous system development)|go:"GO:0007517"(muscle organ development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0043652"(engulfment of apoptotic cell)|go:"GO:0045087"(innate immune response)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:1901741"(positive regulation of myoblast fusion)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|interpro:IPR000203(GPS)|interpro:IPR000832(GPCR, family 2, secretin-like)|interpro:IPR000884(Thrombospondin, type I)|interpro:IPR001879(GPCR, family 2, extracellular region)|interpro:IPR008077(GPCR, family 2, brain-specific angiogenesis inhibitor)|interpro:IPR017981|interpro:IPR032471|interpro:IPR036383|interpro:IPR036445|interpro:IPR043838|mint:O14514 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|caution:"The participant EBI-366647(O75822) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510460(B0QY89) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-366617(Q14152) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2509449() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-353901(Q7L2H7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-347740(P60228) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-348169(P67870) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510446(P61221) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-347451(P19784) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-347804(P68400) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-366632(O75821) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-353741(Q99613) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-354047(Q13347) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2507547() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510474(Q5JT00) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510442(Q9BX72) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-354344(Q9UBQ5) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510439(O95065) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-353818(O15371) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-366696(P55884) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2017/12/08 rogid:p1S78JRQsXwUzzAJkG02ABVWTNs9606 rogid:CM2mofUrH0mg1fj03UflXDeFyvs9606 intact-crc:20F800B7B4841EDE|rigid:i3zuCcUqSmEYgzLsmrtzHSPk68M false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O15372 uniprotkb:Q8N3C0 intact:EBI-709735|ensembl:ENSP00000429931 intact:EBI-1210710|uniprotkb:Q9NTR0|uniprotkb:O43738|uniprotkb:Q5VTN2|uniprotkb:Q9H1I9|uniprotkb:E7EW23|uniprotkb:Q4G1A0|uniprotkb:Q9H5A2|ensembl:ENSP00000358159 psi-mi:eif3h_human(display_long)|uniprotkb:EIF3S3(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 3(gene name synonym)|uniprotkb:eIF-3-gamma(gene name synonym)|uniprotkb:eIF3 p40 subunit(gene name synonym)|uniprotkb:EIF3H(gene name)|psi-mi:EIF3H(display_short) psi-mi:ascc3_human(display_long)|uniprotkb:ASCC3(gene name)|psi-mi:ASCC3(display_short)|uniprotkb:HELIC1(gene name synonym)|uniprotkb:ASC-1 complex subunit p200(gene name synonym)|uniprotkb:Trip4 complex subunit p200(gene name synonym)|uniprotkb:Helicase, ATP binding 1(gene name synonym)|uniprotkb:RQT2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510472|imex:IM-12079-55 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003747.1|ensembl:ENSG00000147677(gene)|ensembl:ENST00000521861(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070122"(isopeptidase activity)|go:"GO:0071541"(eukaryotic translation initiation factor 3 complex, eIF3m)|go:"GO:0101005"(deubiquitinase activity)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR027524|interpro:IPR037518|mint:O15372|rcsb pdb:3J8B|rcsb pdb:3J8C|rcsb pdb:6YBD|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|dip:DIP-33689N refseq:NP_001271200.1|refseq:NP_006819.2|refseq:NP_071374.1|ensembl:ENSG00000112249(gene)|ensembl:ENST00000369162(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006307"(DNA dealkylation involved in DNA repair)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0043138"(3'-5' DNA helicase activity)|go:"GO:0099053"(activating signal cointegrator 1 complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR004179(Sec63)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR027417|interpro:IPR035892|interpro:IPR036388|interpro:IPR036390|mint:Q8N3C0|rcsb pdb:6YXQ|reactome:R-HSA-112126|go:"GO:0005829"(cytosol) psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|caution:"The participant EBI-366647(O75822) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510460(B0QY89) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-366617(Q14152) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2509449() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-353901(Q7L2H7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-347740(P60228) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-348169(P67870) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510446(P61221) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-347451(P19784) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-347804(P68400) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-366632(O75821) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-353741(Q99613) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-354047(Q13347) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2507547() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510474(Q5JT00) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510442(Q9BX72) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-354344(Q9UBQ5) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510439(O95065) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-353818(O15371) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-366696(P55884) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2017/12/08 rogid:p1S78JRQsXwUzzAJkG02ABVWTNs9606 rogid:HAdhxBtWHxdw7k0GkyqBtloVyPY9606 intact-crc:20F800B7B4841EDE|rigid:i3zuCcUqSmEYgzLsmrtzHSPk68M false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O15372 uniprotkb:Q15270 intact:EBI-709735|ensembl:ENSP00000429931 intact:EBI-2510468|ensembl:ENSP00000407978 psi-mi:eif3h_human(display_long)|uniprotkb:EIF3S3(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 3(gene name synonym)|uniprotkb:eIF-3-gamma(gene name synonym)|uniprotkb:eIF3 p40 subunit(gene name synonym)|uniprotkb:EIF3H(gene name)|psi-mi:EIF3H(display_short) psi-mi:nkx11_human(display_long)|uniprotkb:NKX1-1(gene name)|psi-mi:NKX1-1(display_short)|uniprotkb:HPX153(gene name synonym)|uniprotkb:Homeobox protein SAX-2(gene name synonym)|uniprotkb:NKX-1.1(gene name synonym)|uniprotkb:Homeobox protein 153(gene name synonym)|uniprotkb:SAX2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510472|imex:IM-12079-55 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003747.1|ensembl:ENSG00000147677(gene)|ensembl:ENST00000521861(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070122"(isopeptidase activity)|go:"GO:0071541"(eukaryotic translation initiation factor 3 complex, eIF3m)|go:"GO:0101005"(deubiquitinase activity)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR027524|interpro:IPR037518|mint:O15372|rcsb pdb:3J8B|rcsb pdb:3J8C|rcsb pdb:6YBD|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|dip:DIP-33689N ensembl:ENSG00000235608(gene)|ensembl:ENST00000422806(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0010906"(regulation of glucose metabolic process)|go:"GO:0030154"(cell differentiation)|go:"GO:0043467"(regulation of generation of precursor metabolites and energy)|go:"GO:0050877"(nervous system process)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|interpro:IPR020479 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|caution:"The participant EBI-366647(O75822) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510460(B0QY89) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-366617(Q14152) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2509449() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-353901(Q7L2H7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-347740(P60228) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-348169(P67870) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510446(P61221) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-347451(P19784) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-347804(P68400) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-366632(O75821) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-353741(Q99613) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-354047(Q13347) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2507547() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510474(Q5JT00) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510442(Q9BX72) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-354344(Q9UBQ5) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510439(O95065) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-353818(O15371) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-366696(P55884) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2017/12/08 rogid:p1S78JRQsXwUzzAJkG02ABVWTNs9606 rogid:aExyGAxK6xts8FzZFpSB6LLqhrk9606 intact-crc:20F800B7B4841EDE|rigid:i3zuCcUqSmEYgzLsmrtzHSPk68M false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O15372 uniprotkb:O43432 intact:EBI-709735|ensembl:ENSP00000429931 intact:EBI-464766|uniprotkb:Q5SWC3|ensembl:ENSP00000264211|uniprotkb:Q15597|uniprotkb:Q8NEN1|uniprotkb:Q504Z1|uniprotkb:B9EGQ7 psi-mi:eif3h_human(display_long)|uniprotkb:EIF3S3(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 3(gene name synonym)|uniprotkb:eIF-3-gamma(gene name synonym)|uniprotkb:eIF3 p40 subunit(gene name synonym)|uniprotkb:EIF3H(gene name)|psi-mi:EIF3H(display_short) psi-mi:if4g3_human(display_long)|uniprotkb:EIF4G3(gene name)|psi-mi:EIF4G3(display_short)|uniprotkb:eIF-4-gamma II(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510472|imex:IM-12079-55 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003747.1|ensembl:ENSG00000147677(gene)|ensembl:ENST00000521861(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070122"(isopeptidase activity)|go:"GO:0071541"(eukaryotic translation initiation factor 3 complex, eIF3m)|go:"GO:0101005"(deubiquitinase activity)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR027524|interpro:IPR037518|mint:O15372|rcsb pdb:3J8B|rcsb pdb:3J8C|rcsb pdb:6YBD|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|dip:DIP-33689N ensembl:ENST00000264211(transcript)|go:"GO:0000339"(RNA cap binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0008135"(translation factor activity, RNA binding)|go:"GO:0016281"(eukaryotic translation initiation factor 4F complex)|interpro:IPR003307(eIF4-gamma/eIF5/eIF2-epsilon)|interpro:IPR003890(MIF4G-like, type 3)|interpro:IPR003891(Initiation factor eIF-4 gamma, MA3)|interpro:IPR016021(MIF4-like, type 1/2/3)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR037585|mint:O43432|rcsb pdb:1HU3|reactome:R-HSA-1169408|ensembl:ENSG00000075151(gene)|refseq:NP_001185732.1|refseq:NP_003751.2|ensembl:ENSP00000264211|ensembl:ENST00000356916|ensembl:ENSP00000349386|ensembl:ENST00000374935|ensembl:ENSP00000364071|ensembl:ENST00000602326|ensembl:ENSP00000473510|ensembl:ENST00000682284|ensembl:ENSP00000507819|refseq:NP_001185731.1|refseq:NP_001185730.1|refseq:XP_016858189.1|refseq:XP_016858197.1|refseq:XP_016858201.1|dip:DIP-33245N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|caution:"The participant EBI-366647(O75822) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510460(B0QY89) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-366617(Q14152) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2509449() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-353901(Q7L2H7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-347740(P60228) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-348169(P67870) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510446(P61221) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-347451(P19784) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-347804(P68400) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-366632(O75821) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-353741(Q99613) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-354047(Q13347) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2507547() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510474(Q5JT00) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510442(Q9BX72) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-354344(Q9UBQ5) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510439(O95065) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-353818(O15371) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-366696(P55884) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2017/12/08 rogid:p1S78JRQsXwUzzAJkG02ABVWTNs9606 rogid:dN5046U5kz1WfBJD0+NWYMMU6RY9606 intact-crc:20F800B7B4841EDE|rigid:i3zuCcUqSmEYgzLsmrtzHSPk68M false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O15372 uniprotkb:B3KSH1 intact:EBI-709735|ensembl:ENSP00000429931 intact:EBI-2510457 psi-mi:eif3h_human(display_long)|uniprotkb:EIF3S3(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 3(gene name synonym)|uniprotkb:eIF-3-gamma(gene name synonym)|uniprotkb:eIF3 p40 subunit(gene name synonym)|uniprotkb:EIF3H(gene name)|psi-mi:EIF3H(display_short) psi-mi:b3ksh1_human(display_long)|uniprotkb:EIF3F(gene name)|psi-mi:EIF3F(display_short)|uniprotkb:EIF3S5(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 5(gene name synonym)|uniprotkb:eIF-3-epsilon(gene name synonym)|uniprotkb:eIF3 p47(gene name synonym)|uniprotkb:hCG_1784554(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510472|imex:IM-12079-55 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003747.1|ensembl:ENSG00000147677(gene)|ensembl:ENST00000521861(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070122"(isopeptidase activity)|go:"GO:0071541"(eukaryotic translation initiation factor 3 complex, eIF3m)|go:"GO:0101005"(deubiquitinase activity)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR027524|interpro:IPR037518|mint:O15372|rcsb pdb:3J8B|rcsb pdb:3J8C|rcsb pdb:6YBD|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|dip:DIP-33689N go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0070122"(isopeptidase activity)|interpro:IPR024969|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR027531|interpro:IPR037518 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|caution:"The participant EBI-366647(O75822) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510460(B0QY89) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-366617(Q14152) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2509449() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-353901(Q7L2H7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-347740(P60228) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-348169(P67870) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510446(P61221) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-347451(P19784) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-347804(P68400) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-366632(O75821) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-353741(Q99613) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-354047(Q13347) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2507547() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510474(Q5JT00) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510442(Q9BX72) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-354344(Q9UBQ5) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510439(O95065) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-353818(O15371) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-366696(P55884) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2017/12/08 rogid:p1S78JRQsXwUzzAJkG02ABVWTNs9606 rogid:3xYNX/dcd5LtW8Ne+TP0TYHEUqY9606 intact-crc:20F800B7B4841EDE|rigid:i3zuCcUqSmEYgzLsmrtzHSPk68M false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O15372 uniprotkb:Q7Z4H1 intact:EBI-709735|ensembl:ENSP00000429931 intact:EBI-2510464 psi-mi:eif3h_human(display_long)|uniprotkb:EIF3S3(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 3(gene name synonym)|uniprotkb:eIF-3-gamma(gene name synonym)|uniprotkb:eIF3 p40 subunit(gene name synonym)|uniprotkb:EIF3H(gene name)|psi-mi:EIF3H(display_short) psi-mi:q7z4h1_human(display_long)|uniprotkb:HBEBP1(gene name)|psi-mi:HBEBP1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510472|imex:IM-12079-55 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003747.1|ensembl:ENSG00000147677(gene)|ensembl:ENST00000521861(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070122"(isopeptidase activity)|go:"GO:0071541"(eukaryotic translation initiation factor 3 complex, eIF3m)|go:"GO:0101005"(deubiquitinase activity)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR027524|interpro:IPR037518|mint:O15372|rcsb pdb:3J8B|rcsb pdb:3J8C|rcsb pdb:6YBD|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|dip:DIP-33689N - psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|caution:"The participant EBI-366647(O75822) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510460(B0QY89) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-366617(Q14152) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2509449() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-353901(Q7L2H7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-347740(P60228) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-348169(P67870) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510446(P61221) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-347451(P19784) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-347804(P68400) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-366632(O75821) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-353741(Q99613) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-354047(Q13347) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2507547() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510474(Q5JT00) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510442(Q9BX72) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-354344(Q9UBQ5) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510439(O95065) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-353818(O15371) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-366696(P55884) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2017/12/08 rogid:p1S78JRQsXwUzzAJkG02ABVWTNs9606 rogid:vfPT63cW6rj6enxHf86aUjFUapU9606 intact-crc:20F800B7B4841EDE|rigid:i3zuCcUqSmEYgzLsmrtzHSPk68M false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O15372 uniprotkb:P78344 intact:EBI-709735|ensembl:ENSP00000429931 intact:EBI-296519|uniprotkb:O60877|uniprotkb:P78404|uniprotkb:Q0VH00|uniprotkb:Q53EU1|uniprotkb:Q58EZ2|uniprotkb:Q8NI71|uniprotkb:Q96C16|ensembl:ENSP00000340281|ensembl:ENSP00000433371|ensembl:ENSP00000433664|uniprotkb:Q0VH01|uniprotkb:Q2NKW9|uniprotkb:Q49A79 psi-mi:eif3h_human(display_long)|uniprotkb:EIF3S3(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 3(gene name synonym)|uniprotkb:eIF-3-gamma(gene name synonym)|uniprotkb:eIF3 p40 subunit(gene name synonym)|uniprotkb:EIF3H(gene name)|psi-mi:EIF3H(display_short) psi-mi:if4g2_human(display_long)|uniprotkb:EIF4G2(gene name)|psi-mi:EIF4G2(display_short)|uniprotkb:DAP5(gene name synonym)|uniprotkb:OK/SW-cl.75(orf name)|uniprotkb:p97(gene name synonym)|uniprotkb:Death-associated protein 5(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510472|imex:IM-12079-55 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003747.1|ensembl:ENSG00000147677(gene)|ensembl:ENST00000521861(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070122"(isopeptidase activity)|go:"GO:0071541"(eukaryotic translation initiation factor 3 complex, eIF3m)|go:"GO:0101005"(deubiquitinase activity)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR027524|interpro:IPR037518|mint:O15372|rcsb pdb:3J8B|rcsb pdb:3J8C|rcsb pdb:6YBD|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|dip:DIP-33689N ensembl:ENSG00000110321(gene)|ensembl:ENST00000339995(transcript)|ensembl:ENST00000525681(transcript)|ensembl:ENST00000526148(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005912"(adherens junction)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0007507"(heart development)|go:"GO:0008135"(translation factor activity, RNA binding)|go:"GO:0008219"(cell death)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0016020"(membrane)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030424"(axon)|go:"GO:0034645"(cellular macromolecule biosynthetic process)|go:"GO:0045296"(cadherin binding)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060999"(positive regulation of dendritic spine development)|interpro:IPR003307(eIF4-gamma/eIF5/eIF2-epsilon)|interpro:IPR003890(MIF4G-like, type 3)|go:"GO:0016281"(eukaryotic translation initiation factor 4F complex)|interpro:IPR003891(Initiation factor eIF-4 gamma, MA3)|interpro:IPR016021(MIF4-like, type 1/2/3)|interpro:IPR016024(Armadillo-type fold)|mint:P78344|rcsb pdb:3D3M|rcsb pdb:3L6A|rcsb pdb:4IUL|reactome:R-HSA-1169408|refseq:NP_001036024.3|refseq:NP_001166176.1|refseq:NP_001409.3|dip:DIP-31366N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|caution:"The participant EBI-366647(O75822) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510460(B0QY89) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-366617(Q14152) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2509449() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-353901(Q7L2H7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-347740(P60228) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-348169(P67870) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510446(P61221) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-347451(P19784) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-347804(P68400) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-366632(O75821) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-353741(Q99613) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-354047(Q13347) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2507547() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510474(Q5JT00) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510442(Q9BX72) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-354344(Q9UBQ5) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510439(O95065) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-353818(O15371) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-366696(P55884) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2017/12/08 rogid:p1S78JRQsXwUzzAJkG02ABVWTNs9606 rogid:UIE1Um0s2KJ9hpaa9X6kfZ8enPc9606 intact-crc:20F800B7B4841EDE|rigid:i3zuCcUqSmEYgzLsmrtzHSPk68M false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O15372 uniprotkb:Q14240 intact:EBI-709735|ensembl:ENSP00000429931 intact:EBI-73473|intact:EBI-1058347|uniprotkb:Q96B90|uniprotkb:Q96EA8|intact:EBI-2831835|uniprotkb:Q53XJ6|uniprotkb:D3DNU9|ensembl:ENSP00000326381 psi-mi:eif3h_human(display_long)|uniprotkb:EIF3S3(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 3(gene name synonym)|uniprotkb:eIF-3-gamma(gene name synonym)|uniprotkb:eIF3 p40 subunit(gene name synonym)|uniprotkb:EIF3H(gene name)|psi-mi:EIF3H(display_short) psi-mi:if4a2_human(display_long)|uniprotkb:ATP-dependent RNA helicase eIF4A-2(gene name synonym)|uniprotkb:EIF4A2(gene name)|psi-mi:EIF4A2(display_short)|uniprotkb:DDX2B(gene name synonym)|uniprotkb:EIF4F(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510472|imex:IM-12079-55 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003747.1|ensembl:ENSG00000147677(gene)|ensembl:ENST00000521861(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070122"(isopeptidase activity)|go:"GO:0071541"(eukaryotic translation initiation factor 3 complex, eIF3m)|go:"GO:0101005"(deubiquitinase activity)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR027524|interpro:IPR037518|mint:O15372|rcsb pdb:3J8B|rcsb pdb:3J8C|rcsb pdb:6YBD|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|dip:DIP-33689N refseq:NP_001958.2|ensembl:ENSG00000156976(gene)|ensembl:ENST00000323963(transcript)|go:"GO:0002183"(cytoplasmic translational initiation)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0016281"(eukaryotic translation initiation factor 4F complex)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1900260"(negative regulation of RNA-directed 5'-3' RNA polymerase activity)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR000629(RNA helicase, ATP-dependent, DEAD-box, conserved site)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|interpro:IPR044728|mint:Q14240|rcsb pdb:3BOR|reactome:R-HSA-1169408|reactome:R-HSA-156827|reactome:R-HSA-429947|reactome:R-HSA-72649|reactome:R-HSA-72662|reactome:R-HSA-72702|reactome:R-HSA-72706 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|caution:"The participant EBI-366647(O75822) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510460(B0QY89) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-366617(Q14152) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2509449() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-353901(Q7L2H7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-347740(P60228) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-348169(P67870) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510446(P61221) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-347451(P19784) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-347804(P68400) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-366632(O75821) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-353741(Q99613) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-354047(Q13347) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2507547() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510474(Q5JT00) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510442(Q9BX72) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-354344(Q9UBQ5) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510439(O95065) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-353818(O15371) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-366696(P55884) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2017/12/08 rogid:p1S78JRQsXwUzzAJkG02ABVWTNs9606 rogid:m9i/jWfsbU+6kQvj1h06x31+awg9606 intact-crc:20F800B7B4841EDE|rigid:i3zuCcUqSmEYgzLsmrtzHSPk68M false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O15372 uniprotkb:P67870 intact:EBI-709735|ensembl:ENSP00000429931 intact:EBI-348169|ensembl:ENSP00000365025|ensembl:ENSP00000365026|ensembl:ENSP00000365042|ensembl:ENSP00000372919|ensembl:ENSP00000372925|ensembl:ENSP00000382980|ensembl:ENSP00000390900|ensembl:ENSP00000391038|ensembl:ENSP00000393756|ensembl:ENSP00000394855|ensembl:ENSP00000395275|ensembl:ENSP00000400188|ensembl:ENSP00000407018|ensembl:ENSP00000407379|ensembl:ENSP00000409510|ensembl:ENSP00000410802|ensembl:ENSP00000411322|ensembl:ENSP00000412520|ensembl:ENSP00000413469|ensembl:ENSP00000415237|ensembl:ENSP00000415303|uniprotkb:P07312|uniprotkb:P13862|uniprotkb:Q4VX47|intact:EBI-3866975|uniprotkb:B0UXA9 psi-mi:eif3h_human(display_long)|uniprotkb:EIF3S3(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 3(gene name synonym)|uniprotkb:eIF-3-gamma(gene name synonym)|uniprotkb:eIF3 p40 subunit(gene name synonym)|uniprotkb:EIF3H(gene name)|psi-mi:EIF3H(display_short) psi-mi:csk2b_human(display_long)|uniprotkb:Phosvitin(gene name synonym)|uniprotkb:Protein G5a(gene name synonym)|uniprotkb:CSNK2B(gene name)|psi-mi:CSNK2B(display_short)|uniprotkb:CK2N(gene name synonym)|uniprotkb:G5A(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510472|imex:IM-12079-55 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003747.1|ensembl:ENSG00000147677(gene)|ensembl:ENST00000521861(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070122"(isopeptidase activity)|go:"GO:0071541"(eukaryotic translation initiation factor 3 complex, eIF3m)|go:"GO:0101005"(deubiquitinase activity)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR027524|interpro:IPR037518|mint:O15372|rcsb pdb:3J8B|rcsb pdb:3J8C|rcsb pdb:6YBD|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|dip:DIP-33689N ensembl:ENSG00000204435(gene)|ensembl:ENSG00000230700(gene)|ensembl:ENSG00000206406(gene)|ensembl:ENSG00000232960(gene)|ensembl:ENSG00000224398(gene)|ensembl:ENSG00000224774(gene)|ensembl:ENSG00000228875(gene)|ensembl:ENST00000375882(transcript)|ensembl:ENST00000383427(transcript)|ensembl:ENST00000383433(transcript)|ensembl:ENST00000400110(transcript)|ensembl:ENST00000412802(transcript)|ensembl:ENST00000418230(transcript)|ensembl:ENST00000422567(transcript)|ensembl:ENST00000429633(transcript)|ensembl:ENST00000431476(transcript)|ensembl:ENST00000436169(transcript)|ensembl:ENST00000443673(transcript)|ensembl:ENST00000448596(transcript)|ensembl:ENST00000451917(transcript)|ensembl:ENST00000452985(transcript)|ensembl:ENST00000453234(transcript)|ensembl:ENST00000454382(transcript)|ensembl:ENST00000454511(transcript)|ensembl:ENST00000455161(transcript)|ensembl:ENST00000458330(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0005956"(protein kinase CK2 complex)|go:"GO:0007165"(signal transduction)|ensembl:ENST00000375865(transcript)|ensembl:ENST00000375866(transcript)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016363"(nuclear matrix)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032927"(positive regulation of activin receptor signaling pathway)|go:"GO:0033211"(adiponectin-activated signaling pathway)|go:"GO:0033574"(response to testosterone)|go:"GO:0034622"|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042802"(identical protein binding)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0046872"(metal ion binding)|go:"GO:0051101"(regulation of DNA binding)|go:"GO:0061154"(endothelial tube morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0080163"(regulation of protein serine/threonine phosphatase activity)|go:"GO:0097421"(liver regeneration)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000704(Casein kinase II, regulatory subunit)|interpro:IPR016149(Casein kinase II, regulatory subunit, alpha-helical)|interpro:IPR035991|mint:P67870|rcsb pdb:1DS5|rcsb pdb:1JWH|go:"GO:0008134"(transcription factor binding)|rcsb pdb:1QF8|rcsb pdb:3EED|rcsb pdb:4DGL|rcsb pdb:4MD7|rcsb pdb:4MD8|rcsb pdb:4MD9|rcsb pdb:4NH1|reactome:R-HSA-1483191|reactome:R-HSA-201688|reactome:R-HSA-2514853|reactome:R-HSA-445144|reactome:R-HSA-6798695|reactome:R-HSA-6804756|reactome:R-HSA-6814122|reactome:R-HSA-8932339|reactome:R-HSA-8934903|reactome:R-HSA-8939243|reactome:R-HSA-8948751|rcsb pdb:6Q38|refseq:NP_001311.3|refseq:NP_001269314.1|dip:DIP-131N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|caution:"The participant EBI-366647(O75822) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510460(B0QY89) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-366617(Q14152) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2509449() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-353901(Q7L2H7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-347740(P60228) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-348169(P67870) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510446(P61221) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-347451(P19784) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-347804(P68400) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-366632(O75821) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-353741(Q99613) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-354047(Q13347) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2507547() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510474(Q5JT00) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510442(Q9BX72) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-354344(Q9UBQ5) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510439(O95065) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-353818(O15371) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-366696(P55884) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2017/12/08 rogid:p1S78JRQsXwUzzAJkG02ABVWTNs9606 rogid:ZTHJjCqHg2dE7B+WoSU28VSMuPg9606 intact-crc:20F800B7B4841EDE|rigid:i3zuCcUqSmEYgzLsmrtzHSPk68M false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O15372 uniprotkb:P68400 intact:EBI-709735|ensembl:ENSP00000429931 intact:EBI-347804|ensembl:ENSP00000217244|ensembl:ENSP00000383076|ensembl:ENSP00000495248|ensembl:ENSP00000495422|ensembl:ENSP00000495902|ensembl:ENSP00000495912|ensembl:ENSP00000495998|ensembl:ENSP00000496569|uniprotkb:P19138|uniprotkb:P20426|uniprotkb:Q14013|uniprotkb:Q5U065|uniprotkb:D3DVV8|uniprotkb:B4DYS6 psi-mi:eif3h_human(display_long)|uniprotkb:EIF3S3(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 3(gene name synonym)|uniprotkb:eIF-3-gamma(gene name synonym)|uniprotkb:eIF3 p40 subunit(gene name synonym)|uniprotkb:EIF3H(gene name)|psi-mi:EIF3H(display_short) psi-mi:csk21_human(display_long)|uniprotkb:CSNK2A1(gene name)|psi-mi:CSNK2A1(display_short)|uniprotkb:CK2A1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510472|imex:IM-12079-55 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003747.1|ensembl:ENSG00000147677(gene)|ensembl:ENST00000521861(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070122"(isopeptidase activity)|go:"GO:0071541"(eukaryotic translation initiation factor 3 complex, eIF3m)|go:"GO:0101005"(deubiquitinase activity)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR027524|interpro:IPR037518|mint:O15372|rcsb pdb:3J8B|rcsb pdb:3J8C|rcsb pdb:6YBD|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|dip:DIP-33689N rcsb pdb:6TLS|rcsb pdb:6TLU|rcsb pdb:6TLV|rcsb pdb:6TLW|rcsb pdb:6YPG|rcsb pdb:6YPH|rcsb pdb:6YPJ|rcsb pdb:6YPK|rcsb pdb:6YPN|rcsb pdb:6YUL|rcsb pdb:6YUM|rcsb pdb:6YZH|rcsb pdb:6Z19|rcsb pdb:6Z83|rcsb pdb:6Z84|rcsb pdb:7A49|rcsb pdb:6TLR|rcsb pdb:7A4B|rcsb pdb:7A4C|rcsb pdb:7B8H|rcsb pdb:3PE2|rcsb pdb:3PE4|rcsb pdb:3Q04|rcsb pdb:3Q9W|rcsb pdb:3Q9X|rcsb pdb:3Q9Y|rcsb pdb:3Q9Z|rcsb pdb:3QA0|rcsb pdb:3R0T|rcsb pdb:3RPS|rcsb pdb:3TAX|rcsb pdb:3U4U|rcsb pdb:3U87|rcsb pdb:3U9C|rcsb pdb:3W8L|rcsb pdb:3WAR|rcsb pdb:3WIK|rcsb pdb:3WIL|rcsb pdb:3WOW|rcsb pdb:3PE1|rcsb pdb:4DGL|rcsb pdb:4FBX|ensembl:ENSG00000101266(gene)|ensembl:ENST00000217244(transcript)|ensembl:ENST00000400217(transcript)|ensembl:ENST00000643660(transcript)|ensembl:ENST00000645623(transcript)|ensembl:ENST00000646305(transcript)|ensembl:ENST00000646561(transcript)|ensembl:ENST00000646814(transcript)|ensembl:ENST00000647348(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005956"(protein kinase CK2 complex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016301"(kinase activity)|go:"GO:0016580"(Sin3 complex)|go:"GO:0016581"(NuRD complex)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|rcsb pdb:4GUB|rcsb pdb:4GYW|rcsb pdb:4GYY|rcsb pdb:4GZ3|rcsb pdb:4IB5|rcsb pdb:4KWP|rcsb pdb:4MD7|rcsb pdb:4MD8|rcsb pdb:4MD9|rcsb pdb:4NH1|rcsb pdb:4RLL|rcsb pdb:4UB7|rcsb pdb:4GRB|rcsb pdb:4UBA|rcsb pdb:5B0X|rcsb pdb:5CLP|rcsb pdb:5CQU|rcsb pdb:5CQW|rcsb pdb:5CS6|rcsb pdb:5CSH|rcsb pdb:5CSP|rcsb pdb:5CSV|rcsb pdb:7BU4|rcsb pdb:7B8I|reactome:R-HSA-1483191|reactome:R-HSA-201688|reactome:R-HSA-2514853|reactome:R-HSA-445144|reactome:R-HSA-6804756|reactome:R-HSA-6814122|reactome:R-HSA-8932339|reactome:R-HSA-8934903|reactome:R-HSA-8939243|reactome:R-HSA-8948751|rcsb pdb:5CTP|rcsb pdb:5CU0|rcsb pdb:5CU2|rcsb pdb:5CU3|rcsb pdb:5CU4|rcsb pdb:5CU6|rcsb pdb:5CVF|rcsb pdb:5CVG|rcsb pdb:5CVH|rcsb pdb:5CX9|rcsb pdb:5H8B|rcsb pdb:5H8E|rcsb pdb:5H8G|rcsb pdb:5HGV|rcsb pdb:5KU8|rcsb pdb:5KWH|rcsb pdb:5M44|rcsb pdb:5M4C|rcsb pdb:5M4F|rcsb pdb:5M4I|rcsb pdb:5MMF|rcsb pdb:5MMR|rcsb pdb:5MO5|rcsb pdb:5MO6|rcsb pdb:5MO7|rcsb pdb:5MO8|rcsb pdb:5MOD|rcsb pdb:5MOE|rcsb pdb:5MOH|rcsb pdb:5MOT|rcsb pdb:5MOV|rcsb pdb:5MOW|rcsb pdb:5MP8|rcsb pdb:5MPJ|rcsb pdb:5N1V|rcsb pdb:5N9K|rcsb pdb:5N9L|rcsb pdb:5N9N|rcsb pdb:5NQC|rcsb pdb:5OMY|rcsb pdb:5ONI|rcsb pdb:5OQU|rcsb pdb:5ORH|rcsb pdb:5ORJ|rcsb pdb:5ORK|rcsb pdb:5CT0|rcsb pdb:5OT6|rcsb pdb:5OTD|rcsb pdb:5OTH|rcsb pdb:5OTI|rcsb pdb:5OTL|rcsb pdb:5OTO|rcsb pdb:5OTP|rcsb pdb:5OTQ|rcsb pdb:5OTR|rcsb pdb:5OTS|rcsb pdb:5OTY|rcsb pdb:5OTZ|rcsb pdb:5OUE|rcsb pdb:5OS7|rcsb pdb:5OUL|rcsb pdb:5OUM|rcsb pdb:5OS8|rcsb pdb:5OUU|rcsb pdb:5OWH|rcsb pdb:5OSL|rcsb pdb:5OWL|rcsb pdb:5OSP|rcsb pdb:5OYF|rcsb pdb:5T1H|rcsb pdb:5VIE|rcsb pdb:5VIF|rcsb pdb:5ZN0|rcsb pdb:5ZN1|rcsb pdb:5OSR|rcsb pdb:5OSU|rcsb pdb:5OSZ|rcsb pdb:5ZN2|rcsb pdb:5OT5|rcsb pdb:5ZN3|rcsb pdb:5ZN4|rcsb pdb:5ZN5|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048511"(rhythmic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1905818"(regulation of chromosome separation)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P68400|rcsb pdb:1JWH|rcsb pdb:1NA7|rcsb pdb:1PJK|rcsb pdb:2PVR|rcsb pdb:2ZJW|rcsb pdb:3AMY|rcsb pdb:3AT2|rcsb pdb:3AT3|rcsb pdb:3AT4|rcsb pdb:3AXW|rcsb pdb:3BQC|rcsb pdb:3C13|rcsb pdb:3FWQ|rcsb pdb:3H30|rcsb pdb:3JUH|rcsb pdb:3MB6|rcsb pdb:3MB7|rcsb pdb:3NGA|rcsb pdb:3NSZ|interpro:IPR011009(Protein kinase-like)|rcsb pdb:3OWJ|rcsb pdb:3OWK|rcsb pdb:3OWL|rcsb pdb:6E37|rcsb pdb:6EHK|rcsb pdb:6EHU|rcsb pdb:6EII|rcsb pdb:6FVF|rcsb pdb:6FVG|rcsb pdb:6GIH|rcsb pdb:6GMD|rcsb pdb:6HBN|rcsb pdb:6HME|rcsb pdb:6HNW|rcsb pdb:6HNY|rcsb pdb:6HOP|rcsb pdb:6HOQ|rcsb pdb:6HOR|rcsb pdb:6HOT|rcsb pdb:6HOU|rcsb pdb:6JWA|rcsb pdb:6L1Z|rcsb pdb:6L21|rcsb pdb:6L22|rcsb pdb:6L23|rcsb pdb:6L24|rcsb pdb:6Q38|rcsb pdb:6Q4Q|rcsb pdb:6QY7|rcsb pdb:6RB1|rcsb pdb:6RCB|rcsb pdb:6RCM|rcsb pdb:6RFE|rcsb pdb:6RFF|rcsb pdb:6SPW|rcsb pdb:6A1C|rcsb pdb:6SPX|rcsb pdb:6TEI|rcsb pdb:6TLL|rcsb pdb:6TLO|rcsb pdb:6TLP|refseq:NP_001886.1|refseq:NP_808227.1|refseq:NP_808228.1|dip:DIP-32682N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|caution:"The participant EBI-366647(O75822) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510460(B0QY89) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-366617(Q14152) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2509449() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-353901(Q7L2H7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-347740(P60228) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-348169(P67870) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510446(P61221) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-347451(P19784) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-347804(P68400) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-366632(O75821) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-353741(Q99613) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-354047(Q13347) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2507547() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510474(Q5JT00) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510442(Q9BX72) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-354344(Q9UBQ5) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510439(O95065) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-353818(O15371) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-366696(P55884) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2017/12/08 rogid:p1S78JRQsXwUzzAJkG02ABVWTNs9606 rogid:5PLQNJJpbPzJhA0sqogKhl9umIQ9606 intact-crc:20F800B7B4841EDE|rigid:i3zuCcUqSmEYgzLsmrtzHSPk68M false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O15372 uniprotkb:O15372 intact:EBI-709735|ensembl:ENSP00000429931 intact:EBI-709735|ensembl:ENSP00000429931 psi-mi:eif3h_human(display_long)|uniprotkb:EIF3S3(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 3(gene name synonym)|uniprotkb:eIF-3-gamma(gene name synonym)|uniprotkb:eIF3 p40 subunit(gene name synonym)|uniprotkb:EIF3H(gene name)|psi-mi:EIF3H(display_short) psi-mi:eif3h_human(display_long)|uniprotkb:EIF3S3(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 3(gene name synonym)|uniprotkb:eIF-3-gamma(gene name synonym)|uniprotkb:eIF3 p40 subunit(gene name synonym)|uniprotkb:EIF3H(gene name)|psi-mi:EIF3H(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510472|imex:IM-12079-55 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003747.1|ensembl:ENSG00000147677(gene)|ensembl:ENST00000521861(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070122"(isopeptidase activity)|go:"GO:0071541"(eukaryotic translation initiation factor 3 complex, eIF3m)|go:"GO:0101005"(deubiquitinase activity)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR027524|interpro:IPR037518|mint:O15372|rcsb pdb:3J8B|rcsb pdb:3J8C|rcsb pdb:6YBD|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|dip:DIP-33689N refseq:NP_003747.1|ensembl:ENSG00000147677(gene)|ensembl:ENST00000521861(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070122"(isopeptidase activity)|go:"GO:0071541"(eukaryotic translation initiation factor 3 complex, eIF3m)|go:"GO:0101005"(deubiquitinase activity)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR027524|interpro:IPR037518|mint:O15372|rcsb pdb:3J8B|rcsb pdb:3J8C|rcsb pdb:6YBD|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|dip:DIP-33689N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|caution:"The participant EBI-366647(O75822) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510460(B0QY89) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-366617(Q14152) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2509449() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-353901(Q7L2H7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-347740(P60228) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-348169(P67870) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510446(P61221) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-347451(P19784) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-347804(P68400) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-366632(O75821) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-353741(Q99613) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-354047(Q13347) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2507547() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510474(Q5JT00) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510442(Q9BX72) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-354344(Q9UBQ5) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510439(O95065) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-353818(O15371) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-366696(P55884) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2017/12/08 rogid:p1S78JRQsXwUzzAJkG02ABVWTNs9606 rogid:p1S78JRQsXwUzzAJkG02ABVWTNs9606 intact-crc:20F800B7B4841EDE|rigid:i3zuCcUqSmEYgzLsmrtzHSPk68M false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O15372 uniprotkb:Q99613 intact:EBI-709735|ensembl:ENSP00000429931 intact:EBI-353741|uniprotkb:A8K7Z0|intact:EBI-2876652|uniprotkb:O00215|uniprotkb:Q9BW98|uniprotkb:B2RXG3|intact:EBI-11017021|ensembl:ENSP00000332604|ensembl:ENSP00000378953|ensembl:ENSP00000457418|ensembl:ENSP00000457963|uniprotkb:B4E1D5|uniprotkb:H3BRV0 psi-mi:eif3h_human(display_long)|uniprotkb:EIF3S3(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 3(gene name synonym)|uniprotkb:eIF-3-gamma(gene name synonym)|uniprotkb:eIF3 p40 subunit(gene name synonym)|uniprotkb:EIF3H(gene name)|psi-mi:EIF3H(display_short) psi-mi:eif3c_human(display_long)|uniprotkb:EIF3C(gene name)|psi-mi:EIF3C(display_short)|uniprotkb:EIF3S8(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 8(gene name synonym)|uniprotkb:eIF3 p110(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510472|imex:IM-12079-55 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003747.1|ensembl:ENSG00000147677(gene)|ensembl:ENST00000521861(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070122"(isopeptidase activity)|go:"GO:0071541"(eukaryotic translation initiation factor 3 complex, eIF3m)|go:"GO:0101005"(deubiquitinase activity)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR027524|interpro:IPR037518|mint:O15372|rcsb pdb:3J8B|rcsb pdb:3J8C|rcsb pdb:6YBD|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|dip:DIP-33689N refseq:NP_001032897.1|refseq:NP_001186071.1|refseq:NP_003743.1|refseq:NP_001273407.1|ensembl:ENSG00000184110(gene)|ensembl:ENST00000331666(transcript)|ensembl:ENST00000395587(transcript)|ensembl:ENST00000566501(transcript)|ensembl:ENST00000566866(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0043022"(ribosome binding)|go:"GO:0045727"(positive regulation of translation)|go:"GO:1902416"(positive regulation of mRNA binding)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR008905(Eukaryotic translation initiation factor 3 subunit 8, N-terminal)|interpro:IPR027516|interpro:IPR036388|interpro:IPR036390|mint:Q99613|rcsb pdb:3J8B|rcsb pdb:3J8C|rcsb pdb:6YBD|rcsb pdb:6YBW|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|refseq:NP_001254503.1|dip:DIP-32865N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|caution:"The participant EBI-366647(O75822) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510460(B0QY89) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-366617(Q14152) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2509449() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-353901(Q7L2H7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-347740(P60228) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-348169(P67870) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510446(P61221) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-347451(P19784) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-347804(P68400) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-366632(O75821) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-353741(Q99613) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-354047(Q13347) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2507547() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510474(Q5JT00) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510442(Q9BX72) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-354344(Q9UBQ5) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510439(O95065) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-353818(O15371) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-366696(P55884) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2017/12/08 rogid:p1S78JRQsXwUzzAJkG02ABVWTNs9606 rogid:74XQwDW6yxVsob6wZNgfuBlB06M9606 intact-crc:20F800B7B4841EDE|rigid:i3zuCcUqSmEYgzLsmrtzHSPk68M false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O15372 uniprotkb:P48634 intact:EBI-709735|ensembl:ENSP00000429931 intact:EBI-347545|uniprotkb:Q05BK4|uniprotkb:Q4LE37|uniprotkb:Q8MGQ9|uniprotkb:O95875|uniprotkb:Q5SQ29|uniprotkb:Q5SQ30|uniprotkb:Q5ST84|uniprotkb:Q5STX6|uniprotkb:Q5STX7|uniprotkb:Q68DW9|uniprotkb:Q6P9P7|uniprotkb:Q6PIN1|uniprotkb:Q96QC6|uniprotkb:B0UZL3|uniprotkb:B0UZE9|uniprotkb:B0UX77|ensembl:ENSP00000365175|ensembl:ENSP00000365201|ensembl:ENSP00000372947|ensembl:ENSP00000372956|ensembl:ENSP00000387477|ensembl:ENSP00000387910|ensembl:ENSP00000396812|ensembl:ENSP00000400540|ensembl:ENSP00000404619|ensembl:ENSP00000408226|ensembl:ENSP00000409444|ensembl:ENSP00000413977|ensembl:ENSP00000415182|ensembl:ENSP00000415363 psi-mi:eif3h_human(display_long)|uniprotkb:EIF3S3(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 3(gene name synonym)|uniprotkb:eIF-3-gamma(gene name synonym)|uniprotkb:eIF3 p40 subunit(gene name synonym)|uniprotkb:EIF3H(gene name)|psi-mi:EIF3H(display_short) psi-mi:prc2a_human(display_long)|uniprotkb:HLA-B-associated transcript 2(gene name synonym)|uniprotkb:PRRC2A(gene name)|psi-mi:PRRC2A(display_short)|uniprotkb:G2(gene name synonym)|uniprotkb:Protein G2(gene name synonym)|uniprotkb:BAT2(gene name synonym)|uniprotkb:Large proline-rich protein BAT2(gene name synonym)|uniprotkb:Proline-rich and coiled-coil-containing protein 2A(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510472|imex:IM-12079-55 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003747.1|ensembl:ENSG00000147677(gene)|ensembl:ENST00000521861(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070122"(isopeptidase activity)|go:"GO:0071541"(eukaryotic translation initiation factor 3 complex, eIF3m)|go:"GO:0101005"(deubiquitinase activity)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR027524|interpro:IPR037518|mint:O15372|rcsb pdb:3J8B|rcsb pdb:3J8C|rcsb pdb:6YBD|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|dip:DIP-33689N refseq:NP_542417.2|refseq:NP_004629.3|ensembl:ENSP00000372956|ensembl:ENSP00000404619|ensembl:ENSP00000415182|ensembl:ENSP00000415363|ensembl:ENSP00000387910|ensembl:ENSP00000413977|ensembl:ENSP00000408226|ensembl:ENSP00000409444|ensembl:ENSP00000400540|ensembl:ENSP00000387477|ensembl:ENSP00000396812|ensembl:ENSP00000365175|ensembl:ENSP00000365201|ensembl:ENSP00000372947|ensembl:ENSG00000204469(gene)|ensembl:ENSG00000206427(gene)|ensembl:ENSG00000225164(gene)|ensembl:ENSG00000225748(gene)|ensembl:ENSG00000226618(gene)|ensembl:ENSG00000231370(gene)|ensembl:ENSG00000231825(gene)|ensembl:ENST00000376007(transcript)|ensembl:ENST00000376033(transcript)|ensembl:ENST00000383455(transcript)|ensembl:ENST00000383464(transcript)|ensembl:ENST00000414956(transcript)|ensembl:ENST00000416335(transcript)|ensembl:ENST00000422962(transcript)|ensembl:ENST00000428775(transcript)|ensembl:ENST00000430737(transcript)|ensembl:ENST00000432252(transcript)|ensembl:ENST00000435971(transcript)|ensembl:ENST00000439762(transcript)|ensembl:ENST00000454306(transcript)|ensembl:ENST00000458561(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0030154"(cell differentiation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR009738(BAT2, N-terminal)|interpro:IPR033184|mint:P48634 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|caution:"The participant EBI-366647(O75822) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510460(B0QY89) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-366617(Q14152) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2509449() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-353901(Q7L2H7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-347740(P60228) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-348169(P67870) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510446(P61221) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-347451(P19784) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-347804(P68400) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-366632(O75821) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-353741(Q99613) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-354047(Q13347) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2507547() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510474(Q5JT00) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510442(Q9BX72) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-354344(Q9UBQ5) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510439(O95065) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-353818(O15371) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-366696(P55884) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2017/12/08 rogid:p1S78JRQsXwUzzAJkG02ABVWTNs9606 rogid:6XZhA7FHJ4ckoWPf1yI/OnaNwjo9606 intact-crc:20F800B7B4841EDE|rigid:i3zuCcUqSmEYgzLsmrtzHSPk68M false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O15372 uniprotkb:Q9UBQ5 intact:EBI-709735|ensembl:ENSP00000429931 intact:EBI-354344|uniprotkb:Q96IQ0|uniprotkb:Q9Y6D1|intact:EBI-2339187|uniprotkb:A8K0I9|ensembl:ENSP00000248342|ensembl:ENSP00000489438|uniprotkb:B7ZAM9 psi-mi:eif3h_human(display_long)|uniprotkb:EIF3S3(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 3(gene name synonym)|uniprotkb:eIF-3-gamma(gene name synonym)|uniprotkb:eIF3 p40 subunit(gene name synonym)|uniprotkb:EIF3H(gene name)|psi-mi:EIF3H(display_short) psi-mi:eif3k_human(display_long)|uniprotkb:MSTP001(orf name)|uniprotkb:PTD001(orf name)|uniprotkb:HSPC029(orf name)|uniprotkb:EIF3K(gene name)|psi-mi:EIF3K(display_short)|uniprotkb:ARG134(orf name)|uniprotkb:EIF3S12(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 12(gene name synonym)|uniprotkb:eIF-3 p25(gene name synonym)|uniprotkb:eIF-3 p28(gene name synonym)|uniprotkb:Muscle-specific gene M9 protein(gene name synonym)|uniprotkb:PLAC-24(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510472|imex:IM-12079-55 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003747.1|ensembl:ENSG00000147677(gene)|ensembl:ENST00000521861(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070122"(isopeptidase activity)|go:"GO:0071541"(eukaryotic translation initiation factor 3 complex, eIF3m)|go:"GO:0101005"(deubiquitinase activity)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR027524|interpro:IPR037518|mint:O15372|rcsb pdb:3J8B|rcsb pdb:3J8C|rcsb pdb:6YBD|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|dip:DIP-33689N refseq:NP_037366.1|ensembl:ENSG00000282986(gene)|ensembl:ENST00000248342(transcript)|ensembl:ENST00000635567(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003743"(translation initiation factor activity)|ensembl:ENSG00000178982(gene)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0016020"(membrane)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0043022"(ribosome binding)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR009374(Translation initiation factor 3, subunit 12, eukaryotic)|interpro:IPR016020(Translation initiation factor 3, subunit 12, N-terminal, eukaryotic)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR033464|interpro:IPR036388|interpro:IPR036390|mint:Q9UBQ5|rcsb pdb:1RZ4|rcsb pdb:3J8B|rcsb pdb:3J8C|rcsb pdb:6FEC|rcsb pdb:6YBD|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|dip:DIP-32880N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|caution:"The participant EBI-366647(O75822) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510460(B0QY89) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-366617(Q14152) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2509449() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-353901(Q7L2H7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-347740(P60228) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-348169(P67870) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510446(P61221) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-347451(P19784) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-347804(P68400) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-366632(O75821) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-353741(Q99613) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-354047(Q13347) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2507547() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510474(Q5JT00) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510442(Q9BX72) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-354344(Q9UBQ5) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510439(O95065) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-353818(O15371) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-366696(P55884) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2017/12/08 rogid:p1S78JRQsXwUzzAJkG02ABVWTNs9606 rogid:sle5eYxV0F37AzixzoNY4Jm6Loo9606 intact-crc:20F800B7B4841EDE|rigid:i3zuCcUqSmEYgzLsmrtzHSPk68M false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O15372 uniprotkb:O15511 intact:EBI-709735|ensembl:ENSP00000429931 intact:EBI-352975|uniprotkb:A6NEC4|uniprotkb:Q6PG42|ensembl:ENSP00000352918 psi-mi:eif3h_human(display_long)|uniprotkb:EIF3S3(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 3(gene name synonym)|uniprotkb:eIF-3-gamma(gene name synonym)|uniprotkb:eIF3 p40 subunit(gene name synonym)|uniprotkb:EIF3H(gene name)|psi-mi:EIF3H(display_short) psi-mi:arpc5_human(display_long)|uniprotkb:ARPC5(gene name)|psi-mi:ARPC5(display_short)|uniprotkb:ARC16(gene name synonym)|uniprotkb:Arp2/3 complex 16 kDa subunit(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510472|imex:IM-12079-55 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003747.1|ensembl:ENSG00000147677(gene)|ensembl:ENST00000521861(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070122"(isopeptidase activity)|go:"GO:0071541"(eukaryotic translation initiation factor 3 complex, eIF3m)|go:"GO:0101005"(deubiquitinase activity)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR027524|interpro:IPR037518|mint:O15372|rcsb pdb:3J8B|rcsb pdb:3J8C|rcsb pdb:6YBD|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|dip:DIP-33689N refseq:NP_005708.1|refseq:NP_001257368.1|dip:DIP-33144N|ensembl:ENSG00000162704(gene)|ensembl:ENST00000359856(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005885"(Arp2/3 protein complex)|go:"GO:0005925"(focal adhesion)|go:"GO:0014909"(smooth muscle cell migration)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016477"(cell migration)|go:"GO:0021769"(orbitofrontal cortex development)|go:"GO:0030011"(maintenance of cell polarity)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030426"(growth cone)|go:"GO:0034314"(Arp2/3 complex-mediated actin nucleation)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0035861"(site of double-strand break)|go:"GO:0051639"(actin filament network formation)|go:"GO:0061842"(microtubule organizing center localization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097581"(lamellipodium organization)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR006789("ARP2/3 complex 16 kDa subunit (p16-Arc)")|interpro:IPR036743|mint:O15511|rcsb pdb:6UHC|rcsb pdb:6YW7|reactome:R-HSA-2029482|reactome:R-HSA-3928662|reactome:R-HSA-5663213|reactome:R-HSA-6798695|reactome:R-HSA-8856828|reactome:R-HSA-9664422 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|caution:"The participant EBI-366647(O75822) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510460(B0QY89) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-366617(Q14152) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2509449() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-353901(Q7L2H7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-347740(P60228) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-348169(P67870) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510446(P61221) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-347451(P19784) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-347804(P68400) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-366632(O75821) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-353741(Q99613) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-354047(Q13347) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2507547() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510474(Q5JT00) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510442(Q9BX72) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-354344(Q9UBQ5) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510439(O95065) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-353818(O15371) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-366696(P55884) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2017/12/08 rogid:p1S78JRQsXwUzzAJkG02ABVWTNs9606 rogid:kfZQK6CXdREnQNI1h+GlQpB/gPI9606 intact-crc:20F800B7B4841EDE|rigid:i3zuCcUqSmEYgzLsmrtzHSPk68M false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O15372 uniprotkb:O75821 intact:EBI-709735|ensembl:ENSP00000429931 intact:EBI-366632|uniprotkb:O14801|uniprotkb:Q969U5|intact:EBI-28974438|ensembl:ENSP00000253108 psi-mi:eif3h_human(display_long)|uniprotkb:EIF3S3(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 3(gene name synonym)|uniprotkb:eIF-3-gamma(gene name synonym)|uniprotkb:eIF3 p40 subunit(gene name synonym)|uniprotkb:EIF3H(gene name)|psi-mi:EIF3H(display_short) psi-mi:eif3g_human(display_long)|uniprotkb:EIF3G(gene name)|psi-mi:EIF3G(display_short)|uniprotkb:EIF3S4(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 4(gene name synonym)|uniprotkb:eIF-3-delta(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 RNA-binding subunit(gene name synonym)|uniprotkb:eIF3 p44(gene name synonym)|uniprotkb:eIF3 p42(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510472|imex:IM-12079-55 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003747.1|ensembl:ENSG00000147677(gene)|ensembl:ENST00000521861(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070122"(isopeptidase activity)|go:"GO:0071541"(eukaryotic translation initiation factor 3 complex, eIF3m)|go:"GO:0101005"(deubiquitinase activity)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR027524|interpro:IPR037518|mint:O15372|rcsb pdb:3J8B|rcsb pdb:3J8C|rcsb pdb:6YBD|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|dip:DIP-33689N ensembl:ENSP00000253108|refseq:NP_003746.2|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0075525"(viral translational termination-reinitiation)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR017334(Translation initiation factor 3, RNA-binding subunit)|interpro:IPR024675|interpro:IPR034240|interpro:IPR035979|mint:O75821|rcsb pdb:2CQ0|rcsb pdb:2MJC|rcsb pdb:5K0Y|rcsb pdb:6YBS|rcsb pdb:6ZMW|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|ensembl:ENSG00000130811(gene)|ensembl:ENST00000253108(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|dip:DIP-31115N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|caution:"The participant EBI-366647(O75822) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510460(B0QY89) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-366617(Q14152) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2509449() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-353901(Q7L2H7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-347740(P60228) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-348169(P67870) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510446(P61221) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-347451(P19784) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-347804(P68400) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-366632(O75821) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-353741(Q99613) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-354047(Q13347) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2507547() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510474(Q5JT00) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510442(Q9BX72) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-354344(Q9UBQ5) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510439(O95065) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-353818(O15371) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-366696(P55884) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2017/12/08 rogid:p1S78JRQsXwUzzAJkG02ABVWTNs9606 rogid:ZHm8Il08Zyb6kFAavZo4tnuUN4g9606 intact-crc:20F800B7B4841EDE|rigid:i3zuCcUqSmEYgzLsmrtzHSPk68M false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O15372 uniprotkb:O15372 intact:EBI-709735|ensembl:ENSP00000429931 intact:EBI-709735|ensembl:ENSP00000429931 psi-mi:eif3h_human(display_long)|uniprotkb:EIF3S3(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 3(gene name synonym)|uniprotkb:eIF-3-gamma(gene name synonym)|uniprotkb:eIF3 p40 subunit(gene name synonym)|uniprotkb:EIF3H(gene name)|psi-mi:EIF3H(display_short) psi-mi:eif3h_human(display_long)|uniprotkb:EIF3S3(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 3(gene name synonym)|uniprotkb:eIF-3-gamma(gene name synonym)|uniprotkb:eIF3 p40 subunit(gene name synonym)|uniprotkb:EIF3H(gene name)|psi-mi:EIF3H(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510472|imex:IM-12079-55 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003747.1|ensembl:ENSG00000147677(gene)|ensembl:ENST00000521861(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070122"(isopeptidase activity)|go:"GO:0071541"(eukaryotic translation initiation factor 3 complex, eIF3m)|go:"GO:0101005"(deubiquitinase activity)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR027524|interpro:IPR037518|mint:O15372|rcsb pdb:3J8B|rcsb pdb:3J8C|rcsb pdb:6YBD|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|dip:DIP-33689N refseq:NP_003747.1|ensembl:ENSG00000147677(gene)|ensembl:ENST00000521861(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070122"(isopeptidase activity)|go:"GO:0071541"(eukaryotic translation initiation factor 3 complex, eIF3m)|go:"GO:0101005"(deubiquitinase activity)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR027524|interpro:IPR037518|mint:O15372|rcsb pdb:3J8B|rcsb pdb:3J8C|rcsb pdb:6YBD|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|dip:DIP-33689N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|caution:"The participant EBI-366647(O75822) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510460(B0QY89) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-366617(Q14152) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2509449() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-353901(Q7L2H7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-347740(P60228) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-348169(P67870) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510446(P61221) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-347451(P19784) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-347804(P68400) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-366632(O75821) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-353741(Q99613) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-354047(Q13347) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2507547() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510474(Q5JT00) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510442(Q9BX72) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-354344(Q9UBQ5) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510439(O95065) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-353818(O15371) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-366696(P55884) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2017/12/08 rogid:p1S78JRQsXwUzzAJkG02ABVWTNs9606 rogid:p1S78JRQsXwUzzAJkG02ABVWTNs9606 intact-crc:20F800B7B4841EDE|rigid:i3zuCcUqSmEYgzLsmrtzHSPk68M false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O15372 uniprotkb:P61221 intact:EBI-709735|ensembl:ENSP00000429931 intact:EBI-2510446|ensembl:ENSP00000296577|uniprotkb:Q6NR76|uniprotkb:O88793|uniprotkb:Q13181|uniprotkb:Q99K66|uniprotkb:Q13864|uniprotkb:Q96AL0|uniprotkb:Q96B10 psi-mi:eif3h_human(display_long)|uniprotkb:EIF3S3(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 3(gene name synonym)|uniprotkb:eIF-3-gamma(gene name synonym)|uniprotkb:eIF3 p40 subunit(gene name synonym)|uniprotkb:EIF3H(gene name)|psi-mi:EIF3H(display_short) psi-mi:abce1_human(display_long)|uniprotkb:ABCE1(gene name)|psi-mi:ABCE1(display_short)|uniprotkb:RLI(gene name synonym)|uniprotkb:RNASEL1(gene name synonym)|uniprotkb:RNASELI(gene name synonym)|uniprotkb:RNS4I(gene name synonym)|uniprotkb:RNase L inhibitor(gene name synonym)|uniprotkb:Ribonuclease 4 inhibitor(gene name synonym)|uniprotkb:2'-5'-oligoadenylate-binding protein(gene name synonym)|uniprotkb:HuHP68(gene name synonym)|uniprotkb:OK/SW-cl.40(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510472|imex:IM-12079-55 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003747.1|ensembl:ENSG00000147677(gene)|ensembl:ENST00000521861(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070122"(isopeptidase activity)|go:"GO:0071541"(eukaryotic translation initiation factor 3 complex, eIF3m)|go:"GO:0101005"(deubiquitinase activity)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR027524|interpro:IPR037518|mint:O15372|rcsb pdb:3J8B|rcsb pdb:3J8C|rcsb pdb:6YBD|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|dip:DIP-33689N ensembl:ENSG00000164163(gene)|ensembl:ENST00000296577(transcript)|go:"GO:0000054"(ribosomal subunit export from nucleus)|go:"GO:0005506"(iron ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006413"(translational initiation)|go:"GO:0006415"(translational termination)|go:"GO:0006417"(regulation of translation)|go:"GO:0016020"(membrane)|go:"GO:0042626"(ATPase-coupled transmembrane transporter activity)|go:"GO:0043024"(ribosomal small subunit binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0060698"(endoribonuclease inhibitor activity)|go:"GO:0060702"(negative regulation of endoribonuclease activity)|interpro:IPR003439(ABC transporter-like)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR007209(Possible metal-binding region in RNase L inhibitor, RLI)|interpro:IPR013283(ABC transporter, ABCE)|interpro:IPR017871|interpro:IPR017896|interpro:IPR017900|interpro:IPR027417|interpro:IPR034348|mint:P61221|rcsb pdb:6ZME|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-8983711|reactome:R-HSA-909733|refseq:NP_001035809.1|refseq:NP_002931.2 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|caution:"The participant EBI-366647(O75822) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510460(B0QY89) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-366617(Q14152) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2509449() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-353901(Q7L2H7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-347740(P60228) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-348169(P67870) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510446(P61221) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-347451(P19784) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-347804(P68400) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-366632(O75821) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-353741(Q99613) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-354047(Q13347) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2507547() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510474(Q5JT00) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510442(Q9BX72) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-354344(Q9UBQ5) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510439(O95065) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-353818(O15371) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-366696(P55884) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2017/12/08 rogid:p1S78JRQsXwUzzAJkG02ABVWTNs9606 rogid:+6ykpRtI4p94M3TuoTzFBvdCsC09606 intact-crc:20F800B7B4841EDE|rigid:i3zuCcUqSmEYgzLsmrtzHSPk68M false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O15372 uniprotkb:O15372 intact:EBI-709735|ensembl:ENSP00000429931 intact:EBI-709735|ensembl:ENSP00000429931 psi-mi:eif3h_human(display_long)|uniprotkb:EIF3S3(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 3(gene name synonym)|uniprotkb:eIF-3-gamma(gene name synonym)|uniprotkb:eIF3 p40 subunit(gene name synonym)|uniprotkb:EIF3H(gene name)|psi-mi:EIF3H(display_short) psi-mi:eif3h_human(display_long)|uniprotkb:EIF3S3(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 3(gene name synonym)|uniprotkb:eIF-3-gamma(gene name synonym)|uniprotkb:eIF3 p40 subunit(gene name synonym)|uniprotkb:EIF3H(gene name)|psi-mi:EIF3H(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510472|imex:IM-12079-55 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003747.1|ensembl:ENSG00000147677(gene)|ensembl:ENST00000521861(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070122"(isopeptidase activity)|go:"GO:0071541"(eukaryotic translation initiation factor 3 complex, eIF3m)|go:"GO:0101005"(deubiquitinase activity)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR027524|interpro:IPR037518|mint:O15372|rcsb pdb:3J8B|rcsb pdb:3J8C|rcsb pdb:6YBD|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|dip:DIP-33689N refseq:NP_003747.1|ensembl:ENSG00000147677(gene)|ensembl:ENST00000521861(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070122"(isopeptidase activity)|go:"GO:0071541"(eukaryotic translation initiation factor 3 complex, eIF3m)|go:"GO:0101005"(deubiquitinase activity)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR027524|interpro:IPR037518|mint:O15372|rcsb pdb:3J8B|rcsb pdb:3J8C|rcsb pdb:6YBD|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|dip:DIP-33689N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|caution:"The participant EBI-366647(O75822) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510460(B0QY89) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-366617(Q14152) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2509449() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-353901(Q7L2H7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-347740(P60228) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-348169(P67870) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510446(P61221) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-347451(P19784) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-347804(P68400) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-366632(O75821) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-353741(Q99613) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-354047(Q13347) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2507547() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510474(Q5JT00) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510442(Q9BX72) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-354344(Q9UBQ5) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510439(O95065) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-353818(O15371) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-366696(P55884) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2017/12/08 rogid:p1S78JRQsXwUzzAJkG02ABVWTNs9606 rogid:p1S78JRQsXwUzzAJkG02ABVWTNs9606 intact-crc:20F800B7B4841EDE|rigid:i3zuCcUqSmEYgzLsmrtzHSPk68M false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O15372 uniprotkb:O43432 intact:EBI-709735|ensembl:ENSP00000429931 intact:EBI-464766|uniprotkb:Q5SWC3|ensembl:ENSP00000264211|uniprotkb:Q15597|uniprotkb:Q8NEN1|uniprotkb:Q504Z1|uniprotkb:B9EGQ7 psi-mi:eif3h_human(display_long)|uniprotkb:EIF3S3(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 3(gene name synonym)|uniprotkb:eIF-3-gamma(gene name synonym)|uniprotkb:eIF3 p40 subunit(gene name synonym)|uniprotkb:EIF3H(gene name)|psi-mi:EIF3H(display_short) psi-mi:if4g3_human(display_long)|uniprotkb:EIF4G3(gene name)|psi-mi:EIF4G3(display_short)|uniprotkb:eIF-4-gamma II(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510472|imex:IM-12079-55 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003747.1|ensembl:ENSG00000147677(gene)|ensembl:ENST00000521861(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070122"(isopeptidase activity)|go:"GO:0071541"(eukaryotic translation initiation factor 3 complex, eIF3m)|go:"GO:0101005"(deubiquitinase activity)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR027524|interpro:IPR037518|mint:O15372|rcsb pdb:3J8B|rcsb pdb:3J8C|rcsb pdb:6YBD|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|dip:DIP-33689N ensembl:ENST00000264211(transcript)|go:"GO:0000339"(RNA cap binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0008135"(translation factor activity, RNA binding)|go:"GO:0016281"(eukaryotic translation initiation factor 4F complex)|interpro:IPR003307(eIF4-gamma/eIF5/eIF2-epsilon)|interpro:IPR003890(MIF4G-like, type 3)|interpro:IPR003891(Initiation factor eIF-4 gamma, MA3)|interpro:IPR016021(MIF4-like, type 1/2/3)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR037585|mint:O43432|rcsb pdb:1HU3|reactome:R-HSA-1169408|ensembl:ENSG00000075151(gene)|refseq:NP_001185732.1|refseq:NP_003751.2|ensembl:ENSP00000264211|ensembl:ENST00000356916|ensembl:ENSP00000349386|ensembl:ENST00000374935|ensembl:ENSP00000364071|ensembl:ENST00000602326|ensembl:ENSP00000473510|ensembl:ENST00000682284|ensembl:ENSP00000507819|refseq:NP_001185731.1|refseq:NP_001185730.1|refseq:XP_016858189.1|refseq:XP_016858197.1|refseq:XP_016858201.1|dip:DIP-33245N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|caution:"The participant EBI-366647(O75822) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510460(B0QY89) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-366617(Q14152) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2509449() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-353901(Q7L2H7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-347740(P60228) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-348169(P67870) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510446(P61221) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-347451(P19784) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-347804(P68400) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-366632(O75821) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-353741(Q99613) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-354047(Q13347) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2507547() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510474(Q5JT00) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510442(Q9BX72) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-354344(Q9UBQ5) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510439(O95065) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-353818(O15371) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-366696(P55884) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2017/12/08 rogid:p1S78JRQsXwUzzAJkG02ABVWTNs9606 rogid:dN5046U5kz1WfBJD0+NWYMMU6RY9606 intact-crc:20F800B7B4841EDE|rigid:i3zuCcUqSmEYgzLsmrtzHSPk68M false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O15372 uniprotkb:O95065 intact:EBI-709735|ensembl:ENSP00000429931 intact:EBI-2510439 psi-mi:eif3h_human(display_long)|uniprotkb:EIF3S3(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 3(gene name synonym)|uniprotkb:eIF-3-gamma(gene name synonym)|uniprotkb:eIF3 p40 subunit(gene name synonym)|uniprotkb:EIF3H(gene name)|psi-mi:EIF3H(display_short) psi-mi:o95065_human(display_long) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510472|imex:IM-12079-55 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003747.1|ensembl:ENSG00000147677(gene)|ensembl:ENST00000521861(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070122"(isopeptidase activity)|go:"GO:0071541"(eukaryotic translation initiation factor 3 complex, eIF3m)|go:"GO:0101005"(deubiquitinase activity)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR027524|interpro:IPR037518|mint:O15372|rcsb pdb:3J8B|rcsb pdb:3J8C|rcsb pdb:6YBD|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|dip:DIP-33689N go:"GO:0003729"(mRNA binding)|go:"GO:0003743"(translation initiation factor activity)|refseq:NP_886553.3|interpro:IPR037584 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|caution:"The participant EBI-366647(O75822) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510460(B0QY89) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-366617(Q14152) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2509449() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-353901(Q7L2H7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-347740(P60228) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-348169(P67870) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510446(P61221) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-347451(P19784) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-347804(P68400) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-366632(O75821) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-353741(Q99613) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-354047(Q13347) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2507547() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510474(Q5JT00) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510442(Q9BX72) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-354344(Q9UBQ5) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510439(O95065) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-353818(O15371) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-366696(P55884) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2017/12/08 rogid:p1S78JRQsXwUzzAJkG02ABVWTNs9606 rogid:s6TwW41esxJqcvLZsfvjgqS4SiM9606 intact-crc:20F800B7B4841EDE|rigid:i3zuCcUqSmEYgzLsmrtzHSPk68M false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O15372 uniprotkb:Q9BX72 intact:EBI-709735|ensembl:ENSP00000429931 intact:EBI-2510442 psi-mi:eif3h_human(display_long)|uniprotkb:EIF3S3(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 3(gene name synonym)|uniprotkb:eIF-3-gamma(gene name synonym)|uniprotkb:eIF3 p40 subunit(gene name synonym)|uniprotkb:EIF3H(gene name)|psi-mi:EIF3H(display_short) psi-mi:q9bx72_human(display_long)|uniprotkb:IFP38(gene name)|psi-mi:IFP38(display_short)|uniprotkb:EIF3F(gene name synonym)|uniprotkb:EIF3S5(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 5(gene name synonym)|uniprotkb:eIF-3-epsilon(gene name synonym)|uniprotkb:eIF3 p47(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510472|imex:IM-12079-55 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003747.1|ensembl:ENSG00000147677(gene)|ensembl:ENST00000521861(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070122"(isopeptidase activity)|go:"GO:0071541"(eukaryotic translation initiation factor 3 complex, eIF3m)|go:"GO:0101005"(deubiquitinase activity)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR027524|interpro:IPR037518|mint:O15372|rcsb pdb:3J8B|rcsb pdb:3J8C|rcsb pdb:6YBD|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|dip:DIP-33689N go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0070122"(isopeptidase activity)|interpro:IPR024969|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR027531|interpro:IPR037518 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|caution:"The participant EBI-366647(O75822) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510460(B0QY89) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-366617(Q14152) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2509449() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-353901(Q7L2H7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-347740(P60228) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-348169(P67870) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510446(P61221) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-347451(P19784) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-347804(P68400) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-366632(O75821) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-353741(Q99613) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-354047(Q13347) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2507547() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510474(Q5JT00) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510442(Q9BX72) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-354344(Q9UBQ5) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510439(O95065) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-353818(O15371) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-366696(P55884) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2017/12/08 rogid:p1S78JRQsXwUzzAJkG02ABVWTNs9606 rogid:OOc3qYL+oLa30X9bNDW8IpmYvkA9606 intact-crc:20F800B7B4841EDE|rigid:i3zuCcUqSmEYgzLsmrtzHSPk68M false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O15372 uniprotkb:P28676 intact:EBI-709735|ensembl:ENSP00000429931 intact:EBI-947242|uniprotkb:Q53TB5|uniprotkb:Q59EP3|uniprotkb:B2R5X3|ensembl:ENSP00000394842 psi-mi:eif3h_human(display_long)|uniprotkb:EIF3S3(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 3(gene name synonym)|uniprotkb:eIF-3-gamma(gene name synonym)|uniprotkb:eIF3 p40 subunit(gene name synonym)|uniprotkb:EIF3H(gene name)|psi-mi:EIF3H(display_short) psi-mi:gran_human(display_long)|uniprotkb:GCA(gene name)|psi-mi:GCA(display_short)|uniprotkb:GCL(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510472|imex:IM-12079-55 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003747.1|ensembl:ENSG00000147677(gene)|ensembl:ENST00000521861(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070122"(isopeptidase activity)|go:"GO:0071541"(eukaryotic translation initiation factor 3 complex, eIF3m)|go:"GO:0101005"(deubiquitinase activity)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR027524|interpro:IPR037518|mint:O15372|rcsb pdb:3J8B|rcsb pdb:3J8C|rcsb pdb:6YBD|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|dip:DIP-33689N refseq:NP_036330.1|dip:DIP-41437N|ensembl:ENSG00000115271(gene)|ensembl:ENST00000437150(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0061025"(membrane fusion)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|rcsb pdb:1F4O|rcsb pdb:1F4Q|rcsb pdb:1K94|rcsb pdb:1K95|reactome:R-HSA-6798695 psi-mi:"MI:0469"(intact) - crc64:88CA4DDF835AFFE4 figure legend:submitted by author|caution:"The participant EBI-366647(O75822) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510460(B0QY89) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-366617(Q14152) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2509449() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-353901(Q7L2H7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-347740(P60228) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-348169(P67870) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510446(P61221) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-347451(P19784) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-347804(P68400) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-366632(O75821) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-353741(Q99613) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-354047(Q13347) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2507547() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510474(Q5JT00) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510442(Q9BX72) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-354344(Q9UBQ5) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510439(O95065) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-353818(O15371) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-366696(P55884) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2017/12/08 rogid:p1S78JRQsXwUzzAJkG02ABVWTNs9606 rogid:I1zdQPwDUFrBGazaVREgC7nqxok9606 intact-crc:20F800B7B4841EDE|rigid:i3zuCcUqSmEYgzLsmrtzHSPk68M false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O15372 uniprotkb:A0A804HIM8 intact:EBI-709735|ensembl:ENSP00000429931 intact:EBI-2510474|ensembl:ENSP00000507145 psi-mi:eif3h_human(display_long)|uniprotkb:EIF3S3(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 3(gene name synonym)|uniprotkb:eIF-3-gamma(gene name synonym)|uniprotkb:eIF3 p40 subunit(gene name synonym)|uniprotkb:EIF3H(gene name)|psi-mi:EIF3H(display_short) psi-mi:a0a804him8_human(display_long)|uniprotkb:PRRC2B(gene name)|psi-mi:PRRC2B(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510472|imex:IM-12079-55 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003747.1|ensembl:ENSG00000147677(gene)|ensembl:ENST00000521861(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070122"(isopeptidase activity)|go:"GO:0071541"(eukaryotic translation initiation factor 3 complex, eIF3m)|go:"GO:0101005"(deubiquitinase activity)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR027524|interpro:IPR037518|mint:O15372|rcsb pdb:3J8B|rcsb pdb:3J8C|rcsb pdb:6YBD|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|dip:DIP-33689N ensembl:ENSG00000288701(gene)|ensembl:ENST00000684736(transcript)|uniprotkb:Q5JT00(uniprot-removed-ac) psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|caution:"The participant EBI-366647(O75822) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510460(B0QY89) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-366617(Q14152) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2509449() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-353901(Q7L2H7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-347740(P60228) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-348169(P67870) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510446(P61221) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-347451(P19784) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-347804(P68400) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-366632(O75821) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-353741(Q99613) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-354047(Q13347) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2507547() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510474(Q5JT00) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510442(Q9BX72) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-354344(Q9UBQ5) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510439(O95065) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-353818(O15371) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-366696(P55884) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2017/12/08 rogid:p1S78JRQsXwUzzAJkG02ABVWTNs9606 rogid:gWPDAy2o/Vkzm6l9Zj73tFnUxcs9606 intact-crc:20F800B7B4841EDE|rigid:i3zuCcUqSmEYgzLsmrtzHSPk68M false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O15372 uniprotkb:Q14152 intact:EBI-709735|ensembl:ENSP00000429931 intact:EBI-366617|uniprotkb:O00653|uniprotkb:Q15778|uniprotkb:B1AMV5|intact:EBI-28978176|ensembl:ENSP00000358140|ensembl:ENSP00000438178|uniprotkb:B4DYS1|uniprotkb:F5H335 psi-mi:eif3h_human(display_long)|uniprotkb:EIF3S3(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 3(gene name synonym)|uniprotkb:eIF-3-gamma(gene name synonym)|uniprotkb:eIF3 p40 subunit(gene name synonym)|uniprotkb:EIF3H(gene name)|psi-mi:EIF3H(display_short) psi-mi:eif3a_human(display_long)|uniprotkb:EIF3A(gene name)|psi-mi:EIF3A(display_short)|uniprotkb:KIAA0139(gene name synonym)|uniprotkb:EIF3S10(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 10(gene name synonym)|uniprotkb:eIF-3-theta(gene name synonym)|uniprotkb:eIF3 p167(gene name synonym)|uniprotkb:eIF3 p180(gene name synonym)|uniprotkb:eIF3 p185(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510472|imex:IM-12079-55 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003747.1|ensembl:ENSG00000147677(gene)|ensembl:ENST00000521861(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070122"(isopeptidase activity)|go:"GO:0071541"(eukaryotic translation initiation factor 3 complex, eIF3m)|go:"GO:0101005"(deubiquitinase activity)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR027524|interpro:IPR037518|mint:O15372|rcsb pdb:3J8B|rcsb pdb:3J8C|rcsb pdb:6YBD|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|dip:DIP-33689N refseq:NP_003741.1|ensembl:ENSP00000358140|ensembl:ENSP00000438178|ensembl:ENSG00000107581(gene)|ensembl:ENST00000369144(transcript)|ensembl:ENST00000541549(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0002188"(translation reinitiation)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0005874"(microtubule)|go:"GO:0006413"(translational initiation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0043614"(multi-eIF complex)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071540"(eukaryotic translation initiation factor 3 complex, eIF3e)|go:"GO:0071541"(eukaryotic translation initiation factor 3 complex, eIF3m)|go:"GO:0075522"(IRES-dependent viral translational initiation)|go:"GO:0075525"(viral translational termination-reinitiation)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR027512|mint:Q14152|rcsb pdb:3J8B|rcsb pdb:3J8C|rcsb pdb:6YBD|rcsb pdb:6YBT|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|dip:DIP-31114N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|caution:"The participant EBI-366647(O75822) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510460(B0QY89) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-366617(Q14152) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2509449() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-353901(Q7L2H7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-347740(P60228) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-348169(P67870) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510446(P61221) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-347451(P19784) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-347804(P68400) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-366632(O75821) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-353741(Q99613) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-354047(Q13347) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2507547() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510474(Q5JT00) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510442(Q9BX72) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-354344(Q9UBQ5) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510439(O95065) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-353818(O15371) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-366696(P55884) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2017/12/08 rogid:p1S78JRQsXwUzzAJkG02ABVWTNs9606 rogid:COyPBU7e0SUL3BiZY7NQuUkmxns9606 intact-crc:20F800B7B4841EDE|rigid:i3zuCcUqSmEYgzLsmrtzHSPk68M false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O15372 intact:EBI-2507547 intact:EBI-709735|ensembl:ENSP00000429931 - psi-mi:eif3h_human(display_long)|uniprotkb:EIF3S3(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 3(gene name synonym)|uniprotkb:eIF-3-gamma(gene name synonym)|uniprotkb:eIF3 p40 subunit(gene name synonym)|uniprotkb:EIF3H(gene name)|psi-mi:EIF3H(display_short) psi-mi:ipi00004208(display_short)|psi-mi:EBI-2507547(display_long) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510472|imex:IM-12079-55 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003747.1|ensembl:ENSG00000147677(gene)|ensembl:ENST00000521861(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070122"(isopeptidase activity)|go:"GO:0071541"(eukaryotic translation initiation factor 3 complex, eIF3m)|go:"GO:0101005"(deubiquitinase activity)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR027524|interpro:IPR037518|mint:O15372|rcsb pdb:3J8B|rcsb pdb:3J8C|rcsb pdb:6YBD|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|dip:DIP-33689N - psi-mi:"MI:0469"(intact) - no-uniprot-update:An amino acid sequence which is not represented in UniProt figure legend:submitted by author|caution:"The participant EBI-366647(O75822) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510460(B0QY89) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-366617(Q14152) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2509449() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-353901(Q7L2H7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-347740(P60228) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-348169(P67870) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510446(P61221) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-347451(P19784) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-347804(P68400) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-366632(O75821) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-353741(Q99613) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-354047(Q13347) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2507547() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510474(Q5JT00) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510442(Q9BX72) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-354344(Q9UBQ5) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510439(O95065) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-353818(O15371) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-366696(P55884) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2017/12/08 rogid:p1S78JRQsXwUzzAJkG02ABVWTNs9606 rogid:qIclPpO20su7YmGk7m5eOrG6m3Y9606 intact-crc:20F800B7B4841EDE|rigid:i3zuCcUqSmEYgzLsmrtzHSPk68M false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O15372 uniprotkb:P60228 intact:EBI-709735|ensembl:ENSP00000429931 intact:EBI-347740|uniprotkb:O43902|uniprotkb:Q64058|uniprotkb:Q64059|uniprotkb:Q64252|uniprotkb:Q8WVK4|intact:EBI-1237448|uniprotkb:Q6FG33|ensembl:ENSP00000220849 psi-mi:eif3h_human(display_long)|uniprotkb:EIF3S3(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 3(gene name synonym)|uniprotkb:eIF-3-gamma(gene name synonym)|uniprotkb:eIF3 p40 subunit(gene name synonym)|uniprotkb:EIF3H(gene name)|psi-mi:EIF3H(display_short) psi-mi:eif3e_human(display_long)|uniprotkb:EIF3E(gene name)|psi-mi:EIF3E(display_short)|uniprotkb:INT6(gene name synonym)|uniprotkb:EIF3S6(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 6(gene name synonym)|uniprotkb:eIF-3 p48(gene name synonym)|uniprotkb:Viral integration site protein INT-6 homolog(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510472|imex:IM-12079-55 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003747.1|ensembl:ENSG00000147677(gene)|ensembl:ENST00000521861(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070122"(isopeptidase activity)|go:"GO:0071541"(eukaryotic translation initiation factor 3 complex, eIF3m)|go:"GO:0101005"(deubiquitinase activity)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR027524|interpro:IPR037518|mint:O15372|rcsb pdb:3J8B|rcsb pdb:3J8C|rcsb pdb:6YBD|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|dip:DIP-33689N refseq:NP_001559.1|ensembl:ENSG00000104408(gene)|ensembl:ENST00000220849(transcript)|dip:DIP-32691N|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0016020"(membrane)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0016605"(PML body)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0045296"(cadherin binding)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071540"(eukaryotic translation initiation factor 3 complex, eIF3e)|go:"GO:1902416"(positive regulation of mRNA binding)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR016650(Translation initiation factor 3, subunit 6, eukaryotic)|interpro:IPR019010|interpro:IPR036390|mint:P60228|rcsb pdb:3J8B|rcsb pdb:3J8C|rcsb pdb:6FEC|rcsb pdb:6YBD|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|caution:"The participant EBI-366647(O75822) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510460(B0QY89) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-366617(Q14152) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2509449() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-353901(Q7L2H7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-347740(P60228) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-348169(P67870) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510446(P61221) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-347451(P19784) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-347804(P68400) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-366632(O75821) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-353741(Q99613) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-354047(Q13347) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2507547() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510474(Q5JT00) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510442(Q9BX72) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-354344(Q9UBQ5) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510439(O95065) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-353818(O15371) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-366696(P55884) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2017/12/08 rogid:p1S78JRQsXwUzzAJkG02ABVWTNs9606 rogid:s09LicCa0mb9WwO7esZvVdvUonY9606 intact-crc:20F800B7B4841EDE|rigid:i3zuCcUqSmEYgzLsmrtzHSPk68M false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O15372 uniprotkb:Q16891 intact:EBI-709735|ensembl:ENSP00000429931 intact:EBI-473801|uniprotkb:Q68D41|uniprotkb:B2R5N6|uniprotkb:Q14539|uniprotkb:Q15092|uniprotkb:Q69HW5|uniprotkb:Q6IBL0|uniprotkb:Q7Z3X1|uniprotkb:Q8TAJ5|uniprotkb:Q9P0V2|uniprotkb:B1H0U5|ensembl:ENSP00000387262 psi-mi:eif3h_human(display_long)|uniprotkb:EIF3S3(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 3(gene name synonym)|uniprotkb:eIF-3-gamma(gene name synonym)|uniprotkb:eIF3 p40 subunit(gene name synonym)|uniprotkb:EIF3H(gene name)|psi-mi:EIF3H(display_short) psi-mi:mic60_human(display_long)|uniprotkb:Mitofilin(gene name synonym)|uniprotkb:p87/89(gene name synonym)|uniprotkb:Cell proliferation-inducing gene 4/52 protein(gene name synonym)|uniprotkb:MIC60(gene name synonym)|uniprotkb:IMMT(gene name)|psi-mi:IMMT(display_short)|uniprotkb:HMP(gene name synonym)|uniprotkb:MINOS2(gene name synonym)|uniprotkb:Mitochondrial inner membrane protein(gene name synonym)|uniprotkb:PIG4(orf name)|uniprotkb:PIG52(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510472|imex:IM-12079-55 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003747.1|ensembl:ENSG00000147677(gene)|ensembl:ENST00000521861(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070122"(isopeptidase activity)|go:"GO:0071541"(eukaryotic translation initiation factor 3 complex, eIF3m)|go:"GO:0101005"(deubiquitinase activity)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR027524|interpro:IPR037518|mint:O15372|rcsb pdb:3J8B|rcsb pdb:3J8C|rcsb pdb:6YBD|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|dip:DIP-33689N refseq:NP_001093639.1|refseq:NP_001093640.1|refseq:NP_006830.2|refseq:XP_005264170.1|ensembl:ENSG00000132305(gene)|ensembl:ENST00000410111(transcript)|go:"GO:0001401"(SAM complex)|go:"GO:0003723"(RNA binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0007007"(inner mitochondrial membrane organization)|go:"GO:0016020"(membrane)|go:"GO:0042407"(cristae formation)|go:"GO:0051560"(mitochondrial calcium ion homeostasis)|go:"GO:0061617"(MICOS complex)|interpro:IPR019133|mint:Q16891|reactome:R-HSA-8949613|go:"GO:0140275"(MIB complex)|refseq:XP_016858683.1|dip:DIP-32517N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|caution:"The participant EBI-366647(O75822) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510460(B0QY89) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-366617(Q14152) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2509449() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-353901(Q7L2H7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-347740(P60228) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-348169(P67870) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510446(P61221) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-347451(P19784) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-347804(P68400) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-366632(O75821) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-353741(Q99613) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-354047(Q13347) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2507547() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510474(Q5JT00) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510442(Q9BX72) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-354344(Q9UBQ5) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510439(O95065) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-353818(O15371) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-366696(P55884) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2017/12/08 rogid:p1S78JRQsXwUzzAJkG02ABVWTNs9606 rogid:WypdAh4p5IjofFakBmSBwTIWWEs9606 intact-crc:20F800B7B4841EDE|rigid:i3zuCcUqSmEYgzLsmrtzHSPk68M false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O15372 uniprotkb:Q7L2H7 intact:EBI-709735|ensembl:ENSP00000429931 intact:EBI-353901|intact:EBI-4289539|intact:EBI-715219|uniprotkb:Q2F836|uniprotkb:Q53HL6|uniprotkb:Q9BXW1|uniprotkb:O60735|uniprotkb:A8K7X4|intact:EBI-2559366|ensembl:ENSP00000436049|intact:EBI-373200|uniprotkb:B4E2Q4 psi-mi:eif3h_human(display_long)|uniprotkb:EIF3S3(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 3(gene name synonym)|uniprotkb:eIF-3-gamma(gene name synonym)|uniprotkb:eIF3 p40 subunit(gene name synonym)|uniprotkb:EIF3H(gene name)|psi-mi:EIF3H(display_short) psi-mi:eif3m_human(display_long)|uniprotkb:EIF3M(gene name)|psi-mi:EIF3M(display_short)|uniprotkb:HFLB5(gene name synonym)|uniprotkb:PCID1(gene name synonym)|uniprotkb:PCI domain-containing protein 1(gene name synonym)|uniprotkb:Fetal lung protein B5(gene name synonym)|uniprotkb:GA17(orf name)|uniprotkb:PNAS-125(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510472|imex:IM-12079-55 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003747.1|ensembl:ENSG00000147677(gene)|ensembl:ENST00000521861(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070122"(isopeptidase activity)|go:"GO:0071541"(eukaryotic translation initiation factor 3 complex, eIF3m)|go:"GO:0101005"(deubiquitinase activity)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR027524|interpro:IPR037518|mint:O15372|rcsb pdb:3J8B|rcsb pdb:3J8C|rcsb pdb:6YBD|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|dip:DIP-33689N refseq:NP_006351.2|refseq:NP_001294858.1|ensembl:ENSG00000149100(gene)|ensembl:ENST00000531120(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0002183"(cytoplasmic translational initiation)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0071541"(eukaryotic translation initiation factor 3 complex, eIF3m)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR027528|interpro:IPR036390|interpro:IPR040750|mint:Q7L2H7|rcsb pdb:3J8B|rcsb pdb:3J8C|rcsb pdb:6FEC|rcsb pdb:6YBD|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|dip:DIP-31256N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|caution:"The participant EBI-366647(O75822) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510460(B0QY89) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-366617(Q14152) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2509449() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-353901(Q7L2H7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-347740(P60228) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-348169(P67870) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510446(P61221) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-347451(P19784) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-347804(P68400) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-366632(O75821) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-353741(Q99613) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-354047(Q13347) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2507547() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510474(Q5JT00) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510442(Q9BX72) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-354344(Q9UBQ5) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510439(O95065) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-353818(O15371) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-366696(P55884) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2017/12/08 rogid:p1S78JRQsXwUzzAJkG02ABVWTNs9606 rogid:siTfTDezqWL90pw6xG3xUKfY9n49606 intact-crc:20F800B7B4841EDE|rigid:i3zuCcUqSmEYgzLsmrtzHSPk68M false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O15372 uniprotkb:B0QY89 intact:EBI-709735|ensembl:ENSP00000429931 intact:EBI-2510460|ensembl:ENSP00000416892|uniprotkb:E9PB84 psi-mi:eif3h_human(display_long)|uniprotkb:EIF3S3(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 3(gene name synonym)|uniprotkb:eIF-3-gamma(gene name synonym)|uniprotkb:eIF3 p40 subunit(gene name synonym)|uniprotkb:EIF3H(gene name)|psi-mi:EIF3H(display_short) psi-mi:b0qy89_human(display_long)|uniprotkb:EIF3L(gene name)|psi-mi:EIF3L(display_short)|uniprotkb:EIF3EIP(gene name synonym)|uniprotkb:EIF3S6IP(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 6-interacting protein(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit E-interacting protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510472|imex:IM-12079-55 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003747.1|ensembl:ENSG00000147677(gene)|ensembl:ENST00000521861(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070122"(isopeptidase activity)|go:"GO:0071541"(eukaryotic translation initiation factor 3 complex, eIF3m)|go:"GO:0101005"(deubiquitinase activity)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR027524|interpro:IPR037518|mint:O15372|rcsb pdb:3J8B|rcsb pdb:3J8C|rcsb pdb:6YBD|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|dip:DIP-33689N go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019382|ensembl:ENSG00000100129(gene)|ensembl:ENST00000412331(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex) psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|caution:"The participant EBI-366647(O75822) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510460(B0QY89) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-366617(Q14152) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2509449() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-353901(Q7L2H7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-347740(P60228) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-348169(P67870) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510446(P61221) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-347451(P19784) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-347804(P68400) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-366632(O75821) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-353741(Q99613) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-354047(Q13347) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2507547() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510474(Q5JT00) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510442(Q9BX72) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-354344(Q9UBQ5) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510439(O95065) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-353818(O15371) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-366696(P55884) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2017/12/08 rogid:p1S78JRQsXwUzzAJkG02ABVWTNs9606 rogid:9Ig8GRbf2Y8j+VQkYFQqTU1k41A9606 intact-crc:20F800B7B4841EDE|rigid:i3zuCcUqSmEYgzLsmrtzHSPk68M false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O15372 uniprotkb:P19784 intact:EBI-709735|ensembl:ENSP00000429931 intact:EBI-347451|ensembl:ENSP00000262506 psi-mi:eif3h_human(display_long)|uniprotkb:EIF3S3(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 3(gene name synonym)|uniprotkb:eIF-3-gamma(gene name synonym)|uniprotkb:eIF3 p40 subunit(gene name synonym)|uniprotkb:EIF3H(gene name)|psi-mi:EIF3H(display_short) psi-mi:csk22_human(display_long)|uniprotkb:CSNK2A2(gene name)|psi-mi:CSNK2A2(display_short)|uniprotkb:CK2A2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510472|imex:IM-12079-55 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003747.1|ensembl:ENSG00000147677(gene)|ensembl:ENST00000521861(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070122"(isopeptidase activity)|go:"GO:0071541"(eukaryotic translation initiation factor 3 complex, eIF3m)|go:"GO:0101005"(deubiquitinase activity)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR027524|interpro:IPR037518|mint:O15372|rcsb pdb:3J8B|rcsb pdb:3J8C|rcsb pdb:6YBD|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|dip:DIP-33689N refseq:NP_001887.1|dip:DIP-318N|ensembl:ENSG00000070770(gene)|ensembl:ENST00000262506(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005956"(protein kinase CK2 complex)|go:"GO:0006915"(apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0007283"(spermatogenesis)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0097421"(liver regeneration)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1905818"(regulation of chromosome separation)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P19784|rcsb pdb:3E3B|rcsb pdb:3OFM|rcsb pdb:3U87|rcsb pdb:5M4U|rcsb pdb:5M56|rcsb pdb:5OOI|rcsb pdb:5Y9M|rcsb pdb:5YF9|rcsb pdb:5YWM|rcsb pdb:6HMB|rcsb pdb:6HMC|rcsb pdb:6HMD|rcsb pdb:6HMQ|rcsb pdb:6L20|rcsb pdb:6QY8|rcsb pdb:6QY9|rcsb pdb:6TE2|rcsb pdb:6TEW|rcsb pdb:6TGU|rcsb pdb:7A1B|rcsb pdb:7A1Z|rcsb pdb:7A22|rcsb pdb:7A2H|reactome:R-HSA-1483191|reactome:R-HSA-201688|reactome:R-HSA-2514853|reactome:R-HSA-445144|reactome:R-HSA-6804756|reactome:R-HSA-6814122|reactome:R-HSA-8932339|reactome:R-HSA-8934903|reactome:R-HSA-8939243|reactome:R-HSA-8948751 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|caution:"The participant EBI-366647(O75822) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510460(B0QY89) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-366617(Q14152) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2509449() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-353901(Q7L2H7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-347740(P60228) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-348169(P67870) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510446(P61221) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-347451(P19784) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-347804(P68400) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-366632(O75821) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-353741(Q99613) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-354047(Q13347) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2507547() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510474(Q5JT00) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510442(Q9BX72) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-354344(Q9UBQ5) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510439(O95065) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-353818(O15371) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-366696(P55884) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2017/12/08 rogid:p1S78JRQsXwUzzAJkG02ABVWTNs9606 rogid:SIekW2yzNePP9hLKW7OHNFBwNck9606 intact-crc:20F800B7B4841EDE|rigid:i3zuCcUqSmEYgzLsmrtzHSPk68M false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O15372 uniprotkb:P55884 intact:EBI-709735|ensembl:ENSP00000429931 intact:EBI-366696|uniprotkb:Q2NL77|uniprotkb:Q9UMF9|uniprotkb:A4D208|ensembl:ENSP00000354125|ensembl:ENSP00000380206 psi-mi:eif3h_human(display_long)|uniprotkb:EIF3S3(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 3(gene name synonym)|uniprotkb:eIF-3-gamma(gene name synonym)|uniprotkb:eIF3 p40 subunit(gene name synonym)|uniprotkb:EIF3H(gene name)|psi-mi:EIF3H(display_short) psi-mi:eif3b_human(display_long)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 9(gene name synonym)|uniprotkb:eIF-3-eta(gene name synonym)|uniprotkb:eIF3 p116(gene name synonym)|uniprotkb:eIF3 p110(gene name synonym)|uniprotkb:Prt1 homolog(gene name synonym)|uniprotkb:EIF3B(gene name)|psi-mi:EIF3B(display_short)|uniprotkb:EIF3S9(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510472|imex:IM-12079-55 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003747.1|ensembl:ENSG00000147677(gene)|ensembl:ENST00000521861(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070122"(isopeptidase activity)|go:"GO:0071541"(eukaryotic translation initiation factor 3 complex, eIF3m)|go:"GO:0101005"(deubiquitinase activity)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR027524|interpro:IPR037518|mint:O15372|rcsb pdb:3J8B|rcsb pdb:3J8C|rcsb pdb:6YBD|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|dip:DIP-33689N refseq:NP_001032360.1|refseq:NP_003742.2|refseq:XP_011513901.1|refseq:XP_011513902.1|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0031369"(translation initiation factor binding)|ensembl:ENSG00000106263(gene)|ensembl:ENST00000360876(transcript)|ensembl:ENST00000397011(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0045202"(synapse)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071541"(eukaryotic translation initiation factor 3 complex, eIF3m)|go:"GO:0075522"(IRES-dependent viral translational initiation)|go:"GO:0075525"(viral translational termination-reinitiation)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR011400(Translation initiation factor eIF-3b)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR013979(Eukaryotic translation initiation factor 2A, central region)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR034363|interpro:IPR035979|mint:P55884|rcsb pdb:2KRB|rcsb pdb:2NLW|rcsb pdb:5K1H|rcsb pdb:6YBT|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|refseq:XP_016868241.1|dip:DIP-31113N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|caution:"The participant EBI-366647(O75822) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510460(B0QY89) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-366617(Q14152) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2509449() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-353901(Q7L2H7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-347740(P60228) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-348169(P67870) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510446(P61221) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-347451(P19784) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-347804(P68400) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-366632(O75821) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-353741(Q99613) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-354047(Q13347) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2507547() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510474(Q5JT00) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510442(Q9BX72) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-354344(Q9UBQ5) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510439(O95065) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-353818(O15371) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-366696(P55884) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2017/12/08 rogid:p1S78JRQsXwUzzAJkG02ABVWTNs9606 rogid:MxQFPvmuOcO/S+4NqzToozWr8K89606 intact-crc:20F800B7B4841EDE|rigid:i3zuCcUqSmEYgzLsmrtzHSPk68M false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O15372 uniprotkb:P06730 intact:EBI-709735|ensembl:ENSP00000429931 intact:EBI-73440|uniprotkb:Q96E95|ensembl:ENSP00000389624|uniprotkb:D6RCQ6|uniprotkb:B7Z6V1|intact:EBI-28969298 psi-mi:eif3h_human(display_long)|uniprotkb:EIF3S3(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 3(gene name synonym)|uniprotkb:eIF-3-gamma(gene name synonym)|uniprotkb:eIF3 p40 subunit(gene name synonym)|uniprotkb:EIF3H(gene name)|psi-mi:EIF3H(display_short) psi-mi:if4e_human(display_long)|uniprotkb:mRNA cap-binding protein(gene name synonym)|uniprotkb:eIF-4F 25 kDa subunit(gene name synonym)|uniprotkb:EIF4E(gene name)|psi-mi:EIF4E(display_short)|uniprotkb:EIF4EL1(gene name synonym)|uniprotkb:EIF4F(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510472|imex:IM-12079-55 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003747.1|ensembl:ENSG00000147677(gene)|ensembl:ENST00000521861(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070122"(isopeptidase activity)|go:"GO:0071541"(eukaryotic translation initiation factor 3 complex, eIF3m)|go:"GO:0101005"(deubiquitinase activity)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR027524|interpro:IPR037518|mint:O15372|rcsb pdb:3J8B|rcsb pdb:3J8C|rcsb pdb:6YBD|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|dip:DIP-33689N refseq:NP_001124151.1|refseq:NP_001959.1|ensembl:ENST00000280892|ensembl:ENSP00000280892|ensembl:ENSP00000389624|ensembl:ENST00000505992|ensembl:ENSP00000425561|rcsb pdb:2V8X|rcsb pdb:2V8Y|rcsb pdb:2W97|rcsb pdb:3AM7|rcsb pdb:3TF2|rcsb pdb:3U7X|rcsb pdb:4AZA|rcsb pdb:4BEA|rcsb pdb:4DT6|rcsb pdb:4DUM|rcsb pdb:4TPW|rcsb pdb:4TQB|rcsb pdb:4TQC|rcsb pdb:4UED|rcsb pdb:5EHC|rcsb pdb:5EI3|rcsb pdb:5EIR|rcsb pdb:5EKV|rcsb pdb:5GW6|rcsb pdb:5T46|rcsb pdb:5ZJY|rcsb pdb:5ZJZ|rcsb pdb:5ZK5|rcsb pdb:5ZK7|rcsb pdb:5ZK9|ensembl:ENSG00000151247(gene)|rcsb pdb:5ZML|rcsb pdb:7MEU|reactome:R-HSA-1169408|reactome:R-HSA-156827|reactome:R-HSA-159231|reactome:R-HSA-166208|reactome:R-HSA-429947|reactome:R-HSA-72649|reactome:R-HSA-72662|reactome:R-HSA-72702|reactome:R-HSA-72706|reactome:R-HSA-159230|reactome:R-HSA-159227|ensembl:ENST00000450253(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000339"(RNA cap binding)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000932"(P-body)|go:"GO:0001662"(behavioral fear response)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0006417"(regulation of translation)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016281"(eukaryotic translation initiation factor 4F complex)|go:"GO:0016442"(RISC complex)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019899"(enzyme binding)|go:"GO:0030324"(lung development)|go:"GO:0031370"(eukaryotic initiation factor 4G binding)|go:"GO:0033391"(chromatoid body)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR001040("Eukaryotic translation initiation factor 4E (eIF-4E)")|interpro:IPR019770|interpro:IPR023398|mint:P06730|rcsb pdb:1IPB|rcsb pdb:1IPC|rcsb pdb:1WKW|rcsb pdb:2GPQ|rcsb pdb:2V8W|refseq:NP_001124150.1|refseq:NP_001317946.1|dip:DIP-22N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|caution:"The participant EBI-366647(O75822) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510460(B0QY89) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-366617(Q14152) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2509449() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-353901(Q7L2H7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-347740(P60228) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-348169(P67870) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510446(P61221) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-347451(P19784) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-347804(P68400) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-366632(O75821) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-353741(Q99613) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-354047(Q13347) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2507547() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510474(Q5JT00) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510442(Q9BX72) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-354344(Q9UBQ5) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510439(O95065) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-353818(O15371) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-366696(P55884) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2017/12/08 rogid:p1S78JRQsXwUzzAJkG02ABVWTNs9606 rogid:9173bxjOdBfKj36pWVvzw7M6g1A9606 intact-crc:20F800B7B4841EDE|rigid:i3zuCcUqSmEYgzLsmrtzHSPk68M false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O15372 uniprotkb:P23588 intact:EBI-709735|ensembl:ENSP00000429931 intact:EBI-970310|ensembl:ENSP00000262056|uniprotkb:Q4G0E3|uniprotkb:Q53HQ2|uniprotkb:Q6GPH5|uniprotkb:Q6IB46|uniprotkb:Q8WYK5|uniprotkb:B4DS13 psi-mi:eif3h_human(display_long)|uniprotkb:EIF3S3(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 3(gene name synonym)|uniprotkb:eIF-3-gamma(gene name synonym)|uniprotkb:eIF3 p40 subunit(gene name synonym)|uniprotkb:EIF3H(gene name)|psi-mi:EIF3H(display_short) psi-mi:if4b_human(display_long)|uniprotkb:EIF4B(gene name)|psi-mi:EIF4B(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510472|imex:IM-12079-55 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003747.1|ensembl:ENSG00000147677(gene)|ensembl:ENST00000521861(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070122"(isopeptidase activity)|go:"GO:0071541"(eukaryotic translation initiation factor 3 complex, eIF3m)|go:"GO:0101005"(deubiquitinase activity)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR027524|interpro:IPR037518|mint:O15372|rcsb pdb:3J8B|rcsb pdb:3J8C|rcsb pdb:6YBD|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|dip:DIP-33689N ensembl:ENSG00000063046(gene)|ensembl:ENST00000262056(transcript)|go:"GO:0001731"(formation of translation preinitiation complex)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0016281"(eukaryotic translation initiation factor 4F complex)|go:"GO:0030425"(dendrite)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034057"(RNA strand-exchange activity)|go:"GO:0043024"(ribosomal small subunit binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0097010"(eukaryotic translation initiation factor 4F complex assembly)|go:"GO:0098794"(postsynapse)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR033107|interpro:IPR035979|mint:P23588|rcsb pdb:1WI8|rcsb pdb:2J76|rcsb pdb:6FEC|reactome:R-HSA-156827|reactome:R-HSA-166208|reactome:R-HSA-429947|reactome:R-HSA-72649|reactome:R-HSA-72662|reactome:R-HSA-72702|reactome:R-HSA-72706|refseq:NP_001408.2|refseq:NP_001317583.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|caution:"The participant EBI-366647(O75822) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510460(B0QY89) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-366617(Q14152) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2509449() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-353901(Q7L2H7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-347740(P60228) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-348169(P67870) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510446(P61221) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-347451(P19784) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-347804(P68400) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-366632(O75821) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-353741(Q99613) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-354047(Q13347) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2507547() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510474(Q5JT00) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510442(Q9BX72) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-354344(Q9UBQ5) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510439(O95065) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-353818(O15371) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-366696(P55884) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2017/12/08 rogid:p1S78JRQsXwUzzAJkG02ABVWTNs9606 rogid:6QlRkSj6suC5apkUxdZhOq+OMBc9606 intact-crc:20F800B7B4841EDE|rigid:i3zuCcUqSmEYgzLsmrtzHSPk68M false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O15372 uniprotkb:O60573 intact:EBI-709735|ensembl:ENSP00000429931 intact:EBI-398610|uniprotkb:O75349|uniprotkb:B8ZZJ9|ensembl:ENSP00000258416 psi-mi:eif3h_human(display_long)|uniprotkb:EIF3S3(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 3(gene name synonym)|uniprotkb:eIF-3-gamma(gene name synonym)|uniprotkb:eIF3 p40 subunit(gene name synonym)|uniprotkb:EIF3H(gene name)|psi-mi:EIF3H(display_short) psi-mi:if4e2_human(display_long)|uniprotkb:EIF4E2(gene name)|psi-mi:EIF4E2(display_short)|uniprotkb:mRNA cap-binding protein type 3(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 4E-like 3(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 4E homologous protein(gene name synonym)|uniprotkb:mRNA cap-binding protein 4EHP(gene name synonym)|uniprotkb:eIF4E-like protein 4E-LP(gene name synonym)|uniprotkb:EIF4EL3(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510472|imex:IM-12079-55 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003747.1|ensembl:ENSG00000147677(gene)|ensembl:ENST00000521861(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070122"(isopeptidase activity)|go:"GO:0071541"(eukaryotic translation initiation factor 3 complex, eIF3m)|go:"GO:0101005"(deubiquitinase activity)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR027524|interpro:IPR037518|mint:O15372|rcsb pdb:3J8B|rcsb pdb:3J8C|rcsb pdb:6YBD|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|dip:DIP-33689N refseq:NP_004837.1|dip:DIP-32578N|ensembl:ENSG00000135930(gene)|ensembl:ENST00000258416(transcript)|go:"GO:0000339"(RNA cap binding)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000932"(P-body)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0008135"(translation factor activity, RNA binding)|go:"GO:0016281"(eukaryotic translation initiation factor 4F complex)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|interpro:IPR001040("Eukaryotic translation initiation factor 4E (eIF-4E)")|interpro:IPR019770|interpro:IPR023398|mint:O60573|rcsb pdb:2JGB|rcsb pdb:2JGC|rcsb pdb:5NVK|rcsb pdb:5NVL|rcsb pdb:5NVM|rcsb pdb:5NVN|rcsb pdb:5XLN|reactome:R-HSA-1169408|refseq:NP_001263265.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|caution:"The participant EBI-366647(O75822) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510460(B0QY89) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-366617(Q14152) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2509449() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-353901(Q7L2H7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-347740(P60228) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-348169(P67870) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510446(P61221) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-347451(P19784) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-347804(P68400) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-366632(O75821) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-353741(Q99613) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-354047(Q13347) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2507547() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510474(Q5JT00) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510442(Q9BX72) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-354344(Q9UBQ5) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510439(O95065) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-353818(O15371) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-366696(P55884) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2017/12/08 rogid:p1S78JRQsXwUzzAJkG02ABVWTNs9606 rogid:fjre85PBJjEPNVrWjFUUX5NeuEE9606 intact-crc:20F800B7B4841EDE|rigid:i3zuCcUqSmEYgzLsmrtzHSPk68M false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O15372 uniprotkb:O75822 intact:EBI-709735|ensembl:ENSP00000429931 intact:EBI-366647|uniprotkb:Q9BUD2|uniprotkb:Q9H8Q2|uniprotkb:Q9UI65|ensembl:ENSP00000261868|uniprotkb:B4DUI3|uniprotkb:F5H425 psi-mi:eif3h_human(display_long)|uniprotkb:EIF3S3(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 3(gene name synonym)|uniprotkb:eIF-3-gamma(gene name synonym)|uniprotkb:eIF3 p40 subunit(gene name synonym)|uniprotkb:EIF3H(gene name)|psi-mi:EIF3H(display_short) psi-mi:eif3j_human(display_long)|uniprotkb:EIF3J(gene name)|psi-mi:EIF3J(display_short)|uniprotkb:PRO0391(orf name)|uniprotkb:EIF3S1(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 1(gene name synonym)|uniprotkb:eIF-3-alpha(gene name synonym)|uniprotkb:eIF3 p35(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510472|imex:IM-12079-55 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003747.1|ensembl:ENSG00000147677(gene)|ensembl:ENST00000521861(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070122"(isopeptidase activity)|go:"GO:0071541"(eukaryotic translation initiation factor 3 complex, eIF3m)|go:"GO:0101005"(deubiquitinase activity)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR027524|interpro:IPR037518|mint:O15372|rcsb pdb:3J8B|rcsb pdb:3J8C|rcsb pdb:6YBD|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|dip:DIP-33689N refseq:NP_001271264.1|refseq:NP_001271265.1|refseq:NP_003749.2|ensembl:ENSG00000104131(gene)|ensembl:ENST00000261868(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0042802"(identical protein binding)|interpro:IPR013906(Translation initiation factor eIF3 subunit)|interpro:IPR023194|mint:O75822|rcsb pdb:2KRB|rcsb pdb:3BPJ|rcsb pdb:6YBW|rcsb pdb:6ZMW|rcsb pdb:6ZVJ|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|dip:DIP-31117N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|caution:"The participant EBI-366647(O75822) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510460(B0QY89) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-366617(Q14152) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2509449() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-353901(Q7L2H7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-347740(P60228) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-348169(P67870) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510446(P61221) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-347451(P19784) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-347804(P68400) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-366632(O75821) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-353741(Q99613) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-354047(Q13347) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2507547() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510474(Q5JT00) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510442(Q9BX72) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-354344(Q9UBQ5) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510439(O95065) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-353818(O15371) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-366696(P55884) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2017/12/08 rogid:p1S78JRQsXwUzzAJkG02ABVWTNs9606 rogid:dJ+uqlLn3RH30Rw3COnJ+/nkk+I9606 intact-crc:20F800B7B4841EDE|rigid:i3zuCcUqSmEYgzLsmrtzHSPk68M false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O15372 uniprotkb:O15371 intact:EBI-709735|ensembl:ENSP00000429931 intact:EBI-353818|uniprotkb:Q3MJD9|uniprotkb:Q5M9Q6|uniprotkb:B2R7D4|intact:EBI-10969985|ensembl:ENSP00000216190|ensembl:ENSP00000385812|uniprotkb:A8MWD3|uniprotkb:B4DTF8|uniprotkb:B4DVY1 psi-mi:eif3h_human(display_long)|uniprotkb:EIF3S3(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 3(gene name synonym)|uniprotkb:eIF-3-gamma(gene name synonym)|uniprotkb:eIF3 p40 subunit(gene name synonym)|uniprotkb:EIF3H(gene name)|psi-mi:EIF3H(display_short) psi-mi:eif3d_human(display_long)|uniprotkb:EIF3D(gene name)|psi-mi:EIF3D(display_short)|uniprotkb:EIF3S7(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 7(gene name synonym)|uniprotkb:eIF-3-zeta(gene name synonym)|uniprotkb:eIF3 p66(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510472|imex:IM-12079-55 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003747.1|ensembl:ENSG00000147677(gene)|ensembl:ENST00000521861(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070122"(isopeptidase activity)|go:"GO:0071541"(eukaryotic translation initiation factor 3 complex, eIF3m)|go:"GO:0101005"(deubiquitinase activity)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR027524|interpro:IPR037518|mint:O15372|rcsb pdb:3J8B|rcsb pdb:3J8C|rcsb pdb:6YBD|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|dip:DIP-33689N refseq:NP_003744.1|ensembl:ENSG00000100353(gene)|ensembl:ENST00000216190(transcript)|ensembl:ENST00000405442(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0002191"(cap-dependent translational initiation)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0016020"(membrane)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0071541"(eukaryotic translation initiation factor 3 complex, eIF3m)|go:"GO:0075522"(IRES-dependent viral translational initiation)|go:"GO:0075525"(viral translational termination-reinitiation)|go:"GO:0098808"(mRNA cap binding)|go:"GO:1902416"(positive regulation of mRNA binding)|interpro:IPR007783(Eukaryotic translation initiation factor 3, subunit 7)|mint:O15371|rcsb pdb:6YBD|rcsb pdb:6YBS|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|dip:DIP-32870N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|caution:"The participant EBI-366647(O75822) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510460(B0QY89) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-366617(Q14152) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2509449() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-353901(Q7L2H7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-347740(P60228) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-348169(P67870) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510446(P61221) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-347451(P19784) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-347804(P68400) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-366632(O75821) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-353741(Q99613) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-354047(Q13347) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2507547() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510474(Q5JT00) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510442(Q9BX72) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-354344(Q9UBQ5) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510439(O95065) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-353818(O15371) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-366696(P55884) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2017/12/08 rogid:p1S78JRQsXwUzzAJkG02ABVWTNs9606 rogid:hw2nyiDfdecEhLmKA5U9+46bBag9606 intact-crc:20F800B7B4841EDE|rigid:i3zuCcUqSmEYgzLsmrtzHSPk68M false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O15372 uniprotkb:Q13347 intact:EBI-709735|ensembl:ENSP00000429931 intact:EBI-354047|intact:EBI-11759480|ensembl:ENSP00000504034|ensembl:ENSP00000504061|ensembl:ENSP00000502867|ensembl:ENSP00000503348|ensembl:ENSP00000503539 psi-mi:eif3h_human(display_long)|uniprotkb:EIF3S3(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 3(gene name synonym)|uniprotkb:eIF-3-gamma(gene name synonym)|uniprotkb:eIF3 p40 subunit(gene name synonym)|uniprotkb:EIF3H(gene name)|psi-mi:EIF3H(display_short) psi-mi:eif3i_human(display_long)|uniprotkb:EIF3I(gene name)|psi-mi:EIF3I(display_short)|uniprotkb:TRIP1(gene name synonym)|uniprotkb:EIF3S2(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 2(gene name synonym)|uniprotkb:eIF-3-beta(gene name synonym)|uniprotkb:eIF3 p36(gene name synonym)|uniprotkb:TGF-beta receptor-interacting protein 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510472|imex:IM-12079-55 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003747.1|ensembl:ENSG00000147677(gene)|ensembl:ENST00000521861(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070122"(isopeptidase activity)|go:"GO:0071541"(eukaryotic translation initiation factor 3 complex, eIF3m)|go:"GO:0101005"(deubiquitinase activity)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR027524|interpro:IPR037518|mint:O15372|rcsb pdb:3J8B|rcsb pdb:3J8C|rcsb pdb:6YBD|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|dip:DIP-33689N refseq:NP_003748.1|ensembl:ENST00000676801(transcript)|ensembl:ENST00000677202(transcript)|ensembl:ENST00000677701(transcript)|ensembl:ENST00000677711(transcript)|ensembl:ENST00000677760(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0002183"(cytoplasmic translational initiation)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071541"(eukaryotic translation initiation factor 3 complex, eIF3m)|ensembl:ENSG00000084623(gene)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR027525|interpro:IPR036322|mint:Q13347|rcsb pdb:6YBT|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|dip:DIP-31116N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|caution:"The participant EBI-366647(O75822) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510460(B0QY89) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-366617(Q14152) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2509449() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-353901(Q7L2H7) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-347740(P60228) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-348169(P67870) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510446(P61221) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-347451(P19784) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-347804(P68400) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-366632(O75821) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-353741(Q99613) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-354047(Q13347) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2507547() was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510474(Q5JT00) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510442(Q9BX72) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-354344(Q9UBQ5) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-2510439(O95065) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-353818(O15371) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|caution:"The participant EBI-366696(P55884) was duplicated. It is posssible that originally this interaction did contain more participants pointing to different Trembl proteins which have been merged to a single swissprot protein later."|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2017/12/08 rogid:p1S78JRQsXwUzzAJkG02ABVWTNs9606 rogid:fogC6nSNmIynV2ziHZboT9laA3M9606 intact-crc:20F800B7B4841EDE|rigid:i3zuCcUqSmEYgzLsmrtzHSPk68M false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q15040 uniprotkb:O60220 intact:EBI-2510602|ensembl:ENSP00000216039|ensembl:ENSP00000506752|uniprotkb:A8K712 intact:EBI-1049822|uniprotkb:Q6IRW6|uniprotkb:B2R5A6|ensembl:ENSP00000361993 psi-mi:jos1_human(display_long)|uniprotkb:JOSD1(gene name)|psi-mi:JOSD1(display_short)|uniprotkb:JSPH1(gene name synonym)|uniprotkb:KIAA0063(gene name synonym)|uniprotkb:Josephin domain-containing protein 1(gene name synonym) psi-mi:tim8a_human(display_long)|uniprotkb:Deafness dystonia protein 1(gene name synonym)|uniprotkb:X-linked deafness dystonia protein(gene name synonym)|uniprotkb:TIMM8A(gene name)|psi-mi:TIMM8A(display_short)|uniprotkb:DDP(gene name synonym)|uniprotkb:DDP1(gene name synonym)|uniprotkb:TIM8A(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510600|imex:IM-12079-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000100221(gene)|ensembl:ENST00000216039(transcript)|ensembl:ENST00000683374(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0016579"(protein deubiquitination)|interpro:IPR006155(Machado-Joseph disease protein MJD)|interpro:IPR040053|mint:Q15040|reactome:R-HSA-5689877|refseq:NP_055691.1|refseq:XP_005261933.1|refseq:XP_005261934.1|refseq:XP_005261935.1|refseq:XP_005261936.1 refseq:NP_004076.1|reactome:R-HSA-1268020|ensembl:ENSG00000126953(gene)|ensembl:ENST00000372902(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0007399"(nervous system development)|go:"GO:0042802"(identical protein binding)|go:"GO:0045039"(protein insertion into mitochondrial inner membrane)|go:"GO:0046872"(metal ion binding)|interpro:IPR004217(Zinc finger, Tim10/DDP-type)|interpro:IPR035427|interpro:IPR039238|mint:O60220 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:n5Nf09Ce5oUJULfhF6PJ7cfgVJw9606 rogid:v01DxxXFU24eNjL3zVBvqQP9zA49606 intact-crc:CB438212FBEF9689|rigid:m2RScOBhwgCnYjaP5Akwf6/IaI4 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q15040 uniprotkb:P62158 intact:EBI-2510602|ensembl:ENSP00000216039|ensembl:ENSP00000506752|uniprotkb:A8K712 intact:EBI-397435|uniprotkb:P02593|uniprotkb:P70667|uniprotkb:P99014|uniprotkb:Q13942|uniprotkb:Q53S29|uniprotkb:Q61379|uniprotkb:Q61380|uniprotkb:Q96HK3|uniprotkb:P0DP25|uniprotkb:P0DP24|uniprotkb:P0DP23 psi-mi:jos1_human(display_long)|uniprotkb:JOSD1(gene name)|psi-mi:JOSD1(display_short)|uniprotkb:JSPH1(gene name synonym)|uniprotkb:KIAA0063(gene name synonym)|uniprotkb:Josephin domain-containing protein 1(gene name synonym) psi-mi:calm_human(display_long)|uniprotkb:CALM1(gene name)|psi-mi:CALM1(display_short)|uniprotkb:CALM(gene name synonym)|uniprotkb:CAM(gene name synonym)|uniprotkb:CAM1(gene name synonym)|uniprotkb:CALM2(gene name)|psi-mi:CALM2(display_short)|uniprotkb:CAMB(gene name synonym)|uniprotkb:CALM3(gene name)|psi-mi:CALM3(display_short)|uniprotkb:CAM3(gene name synonym)|uniprotkb:CAMC(gene name synonym)|uniprotkb:CAMIII(gene name synonym)|uniprotkb:CAM2(gene name synonym)|uniprotkb:CALML2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510600|imex:IM-12079-5 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000100221(gene)|ensembl:ENST00000216039(transcript)|ensembl:ENST00000683374(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0016579"(protein deubiquitination)|interpro:IPR006155(Machado-Joseph disease protein MJD)|interpro:IPR040053|mint:Q15040|reactome:R-HSA-5689877|refseq:NP_055691.1|refseq:XP_005261933.1|refseq:XP_005261934.1|refseq:XP_005261935.1|refseq:XP_005261936.1 rcsb pdb:3SUI|rcsb pdb:2LGF|rcsb pdb:2LQC|rcsb pdb:2LQP|rcsb pdb:2Y4V|rcsb pdb:4JQ0|rcsb pdb:4LZX|rcsb pdb:4M1L|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|rcsb pdb:3J41|rcsb pdb:2LL6|go:"GO:0002027"(regulation of heart rate)|go:"GO:0005513"(detection of calcium ion)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0030017"(sarcomere)|go:"GO:0030801"(obsolete positive regulation of cyclic nucleotide metabolic process)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0051343"(positive regulation of cyclic-nucleotide phosphodiesterase activity)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1901844"(regulation of cell communication by electrical coupling involved in cardiac conduction)|rcsb pdb:2LV6|rcsb pdb:2N6A|refseq:NP_001734.1|refseq:NP_005175.2|refseq:NP_008819.1|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR002048(Calcium-binding EF-hand)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005876"(spindle microtubule)|go:"GO:0000922"(spindle pole)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005980"(glycogen catabolic process)|go:"GO:0006936"(muscle contraction)|go:"GO:0060315"(negative regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0002576"(platelet degranulation)|go:"GO:0060316"(positive regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0050999"(regulation of nitric-oxide synthase activity)|rcsb pdb:1AJI|rcsb pdb:1CDL|rcsb pdb:1CLL|rcsb pdb:1CTR|rcsb pdb:1IWQ|rcsb pdb:1J7O|rcsb pdb:1J7P|rcsb pdb:1K90|rcsb pdb:1K93|rcsb pdb:1L7Z|rcsb pdb:1LVC|rcsb pdb:1NKF|rcsb pdb:1PK0|rcsb pdb:1S26|rcsb pdb:1SK6|rcsb pdb:1SW8|rcsb pdb:1WRZ|rcsb pdb:1XFU|rcsb pdb:1XFV|rcsb pdb:1XFW|rcsb pdb:1XFX|rcsb pdb:1XFY|rcsb pdb:1XFZ|rcsb pdb:1Y6W|rcsb pdb:1YR5|rcsb pdb:1YRT|rcsb pdb:1YRU|rcsb pdb:1ZOT|rcsb pdb:1ZUZ|rcsb pdb:2BE6|rcsb pdb:2F3Y|rcsb pdb:2F3Z|rcsb pdb:2HF5|rcsb pdb:2I08|rcsb pdb:2JZI|rcsb pdb:2K0E|rcsb pdb:2K0F|rcsb pdb:2K0J|rcsb pdb:2K61|rcsb pdb:2KNE|rcsb pdb:2KUG|rcsb pdb:2KUH|rcsb pdb:2L53|rcsb pdb:2L7L|rcsb pdb:2R28|rcsb pdb:2V01|rcsb pdb:2V02|rcsb pdb:2VAY|rcsb pdb:2W73|rcsb pdb:2WEL|rcsb pdb:2X0G|rcsb pdb:3BYA|rcsb pdb:3DVE|rcsb pdb:3DVJ|rcsb pdb:3DVK|rcsb pdb:3DVM|rcsb pdb:3EWT|rcsb pdb:3EWV|rcsb pdb:3G43|rcsb pdb:3HR4|rcsb pdb:3O77|rcsb pdb:3O78|rcsb pdb:3OXQ|rcsb pdb:3UCT|rcsb pdb:3UCW|rcsb pdb:3UCY|rcsb pdb:4DCK|go:"GO:0010801"(negative regulation of peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031954"(positive regulation of protein autophosphorylation)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0000165"(MAPK cascade)|rcsb pdb:2M0J|rcsb pdb:2M0K|rcsb pdb:4UMO|rcsb pdb:4V0C|go:"GO:0031982"(vesicle)|rcsb pdb:4Q5U|rcsb pdb:4UPU|reactome:R-HSA-2672351|reactome:R-HSA-418359|reactome:R-HSA-425561|reactome:R-HSA-5576892|reactome:R-HSA-5578775|reactome:R-HSA-936837|refseq:NP_001292555.1|rcsb pdb:4OVN|rcsb pdb:5COC|go:"GO:0021762"(substantia nigra development)|go:"GO:0070062"(extracellular exosome)|rcsb pdb:4BW7|rcsb pdb:4BW8|rcsb pdb:4L79|rcsb pdb:5DBR|rcsb pdb:4DJC|rcsb pdb:2M55|rcsb pdb:2LL7|go:"GO:0019855"(calcium channel inhibitor activity)|go:"GO:0001975"(response to amphetamine)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030426"(growth cone)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051412"(response to corticosterone)|go:"GO:1901841"(regulation of high voltage-gated calcium channel activity)|rcsb pdb:2N77|go:"GO:0032991"(protein-containing complex)|go:"GO:0006479"(protein methylation)|go:"GO:0014069"(postsynaptic density)|rcsb pdb:5DSU|reactome:R-HSA-8876725|rcsb pdb:4GOW|rcsb pdb:4Q57|go:"GO:0043647"(inositol phosphate metabolic process)|go:"GO:0022400"(regulation of rhodopsin mediated signaling pathway)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0010880"(regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031432"(titin binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0031997"(N-terminal myristoylation domain binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0051592"(response to calcium ion)|go:"GO:0055117"(regulation of cardiac muscle contraction)|rcsb pdb:2MG5|go:"GO:0005088"|go:"GO:0007223"(Wnt signaling pathway, calcium modulating pathway)|go:"GO:0008440"(inositol-1,4,5-trisphosphate 3-kinase activity)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0005634"(nucleus)|rcsb pdb:4JPZ|ensembl:ENST00000272298|ensembl:ENST00000291295|ensembl:ENST00000356978|ensembl:ENST00000596362|refseq:NP_001292553.1|refseq:NP_001292554.1|rcsb pdb:4BYF|reactome:R-HSA-111932|reactome:R-HSA-111933|reactome:R-HSA-111957|reactome:R-HSA-111997|reactome:R-HSA-114608|reactome:R-HSA-1445148|reactome:R-HSA-1474151|reactome:R-HSA-180024|reactome:R-HSA-1855204|reactome:R-HSA-203615|reactome:R-HSA-2514859|reactome:R-HSA-2871809|reactome:R-HSA-4086398|reactome:R-HSA-442717|reactome:R-HSA-442729|reactome:R-HSA-442745|reactome:R-HSA-442982|reactome:R-HSA-445355|reactome:R-HSA-451308|reactome:R-HSA-5218920|reactome:R-HSA-5218921|reactome:R-HSA-5607763|reactome:R-HSA-5626467|reactome:R-HSA-5627123|reactome:R-HSA-5673001|reactome:R-HSA-70221|reactome:R-HSA-983695|ensembl:ENSG00000143933|ensembl:ENSG00000160014|ensembl:ENSG00000198668|ensembl:ENSP00000272298|ensembl:ENSP00000291295|ensembl:ENSP00000349467|ensembl:ENSP00000472141|rcsb pdb:5NIN|rcsb pdb:5VMS|rcsb pdb:5WSU|rcsb pdb:5WSV|rcsb pdb:6U39|rcsb pdb:6U3A|rcsb pdb:6U3B|rcsb pdb:6U3D|rcsb pdb:2N8J|rcsb pdb:5GGM|rcsb pdb:5J8H|reactome:R-HSA-163615|reactome:R-HSA-5210891|refseq:NP_001316851.1|refseq:NP_001316852.1|refseq:NP_001316853.1|refseq:NP_001316854.1|refseq:NP_001316855.1|rcsb pdb:2N27|rcsb pdb:5DOW|rcsb pdb:5I0I|rcsb pdb:5J03|rcsb pdb:5K7L|rcsb pdb:5K8Q|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0043388"(positive regulation of DNA binding)|dip:DIP-31794N|rcsb pdb:1UP5|rcsb pdb:5JQA|rcsb pdb:5JTH|rcsb pdb:5OEO|rcsb pdb:5TP5|rcsb pdb:5TP6|rcsb pdb:5V02|rcsb pdb:5V03|rcsb pdb:5V7X|rcsb pdb:5WBX|rcsb pdb:5WC5|rcsb pdb:6B8L|rcsb pdb:6B8M|rcsb pdb:6B8N|rcsb pdb:6B8P|rcsb pdb:6B8Q|rcsb pdb:6C1D|rcsb pdb:6C1G|rcsb pdb:6C1H|rcsb pdb:6CNM|rcsb pdb:6CNN|rcsb pdb:6CNO|rcsb pdb:6FEG|rcsb pdb:6FEH|reactome:R-HSA-2025928|reactome:R-HSA-2151201|go:"GO:0034704"(calcium channel complex)|go:"GO:0010856"(adenylate cyclase activator activity)|go:"GO:0051186"(obsolete cofactor metabolic process)|go:"GO:0075206"(obsolete positive regulation by host of symbiont cAMP-mediated signal transduction)|go:"GO:0060314"(regulation of ryanodine-sensitive calcium-release channel activity)|interpro:IPR039030|go:"GO:1902494"(catalytic complex)|go:"GO:0043234"|go:"GO:0008179"(adenylate cyclase binding)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0030819"(obsolete positive regulation of cAMP biosynthetic process)|rcsb pdb:6BUT|rcsb pdb:6DAD|rcsb pdb:6DAE|rcsb pdb:6DAF|rcsb pdb:6DAH|rcsb pdb:6E2F|rcsb pdb:6E2G|rcsb pdb:6EEB|rcsb pdb:6GDK|rcsb pdb:6GDL|rcsb pdb:6HCS|rcsb pdb:6JI8|rcsb pdb:6JII|rcsb pdb:6JIU|rcsb pdb:6JIY|rcsb pdb:6JRS|rcsb pdb:6JV2|rcsb pdb:6K4K|rcsb pdb:6K4L|rcsb pdb:6K4R|rcsb pdb:6MUD|rcsb pdb:6MUE|rcsb pdb:6N5W|rcsb pdb:6O5G|reactome:R-HSA-438066|reactome:R-HSA-442720|reactome:R-HSA-5673000|reactome:R-HSA-6802946|reactome:R-HSA-6802949|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-9009391|reactome:R-HSA-9022535|reactome:R-HSA-9022692|reactome:R-HSA-9617324|reactome:R-HSA-9619229|reactome:R-HSA-9619483|reactome:R-HSA-9620244|go:"GO:0019722"(calcium-mediated signaling)|rcsb pdb:6PBX|rcsb pdb:6PBY|reactome:R-HSA-9649948|go:"GO:0005623"(obsolete cell)|rcsb pdb:6HR1|rcsb pdb:6OS4|rcsb pdb:6Y4P|rcsb pdb:6Y94|rcsb pdb:6Y95|reactome:R-HSA-9664323|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0016032"(viral process)|rcsb pdb:6M7H|rcsb pdb:6UZZ|rcsb pdb:6V00|rcsb pdb:6V01|rcsb pdb:6PLM|rcsb pdb:6S5T|rcsb pdb:6SZ5|rcsb pdb:6XXF|rcsb pdb:6Y4O psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:n5Nf09Ce5oUJULfhF6PJ7cfgVJw9606 rogid:tTYcOd9bOh211njZVz7cYVybAMQ9606 intact-crc:CB438212FBEF9689|rigid:m2RScOBhwgCnYjaP5Akwf6/IaI4 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q7Z7N5 uniprotkb:P51531 intact:EBI-2510617 intact:EBI-679562|uniprotkb:B1ALG3|uniprotkb:B1ALG4|uniprotkb:D3DRH4|uniprotkb:D3DRH5|ensembl:ENSP00000265773|ensembl:ENSP00000371638 psi-mi:q7z7n5_human(display_long)|uniprotkb:JOSD2(gene name)|psi-mi:JOSD2(display_short) psi-mi:smca2_human(display_long)|uniprotkb:ATP-dependent helicase SMARCA2(gene name synonym)|uniprotkb:SNF2-alpha(gene name synonym)|uniprotkb:SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2(gene name synonym)|uniprotkb:SMARCA2(gene name)|psi-mi:SMARCA2(display_short)|uniprotkb:BRM(gene name synonym)|uniprotkb:SNF2A(gene name synonym)|uniprotkb:SNF2L2(gene name synonym)|uniprotkb:BAF190B(gene name synonym)|uniprotkb:Protein brahma homolog(gene name synonym)|uniprotkb:BRG1-associated factor 190B(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510621|imex:IM-12079-56 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0016579"(protein deubiquitination)|interpro:IPR006155(Machado-Joseph disease protein MJD)|interpro:IPR040053|refseq:NP_001257569.1 refseq:NP_003061.3|refseq:NP_620614.2|refseq:NP_001276325.1|refseq:NP_001276326.1|dip:DIP-29005N|ensembl:ENSG00000080503(gene)|ensembl:ENST00000349721(transcript)|ensembl:ENST00000382203(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007286"(spermatid development)|go:"GO:0007399"(nervous system development)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016514"(SWI/SNF complex)|go:"GO:0016787"(hydrolase activity)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0042393"(histone binding)|go:"GO:0043044"|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070615"|go:"GO:0071564"(npBAF complex)|go:"GO:0071565"(nBAF complex)|interpro:IPR000330(SNF2-related)|interpro:IPR001487(Bromodomain)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR006576(BRK)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014012(Helicase/SANT-associated, DNA binding)|interpro:IPR014978(QLQ)|interpro:IPR018359|interpro:IPR027417|interpro:IPR029295|interpro:IPR030088|interpro:IPR036427|interpro:IPR037259|interpro:IPR038718|mint:P51531|rcsb pdb:2DAT|rcsb pdb:4QY4|rcsb pdb:5DKC|rcsb pdb:5DKH|rcsb pdb:6EG2|rcsb pdb:6EG3|rcsb pdb:6HAX|rcsb pdb:6HAY|rcsb pdb:6HAZ|reactome:R-HSA-3214858|reactome:R-HSA-8939243 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:YMdnfXIXV0dPityr5zlAu2wy+yM9606 rogid:DmQot4h4SmtqmUGBgF5ictTah289606 intact-crc:DB1D15B78D9DA6F5|rigid:ARf3Zo8Xq9YQl01z/wGuqg0FS2M false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q7Z7N5 uniprotkb:O43865 intact:EBI-2510617 intact:EBI-2371423|uniprotkb:Q2TAJ6|uniprotkb:Q502W8|uniprotkb:Q5VSM0|uniprotkb:Q6P171|uniprotkb:Q96PK4|uniprotkb:Q9UG84|uniprotkb:B4E168|ensembl:ENSP00000358814 psi-mi:q7z7n5_human(display_long)|uniprotkb:JOSD2(gene name)|psi-mi:JOSD2(display_short) psi-mi:sahh2_human(display_long)|uniprotkb:AHCYL1(gene name)|psi-mi:AHCYL1(display_short)|uniprotkb:DCAL(gene name synonym)|uniprotkb:XPVKONA(gene name synonym)|uniprotkb:S-adenosyl-L-homocysteine hydrolase 2(gene name synonym)|uniprotkb:DC-expressed AHCY-like molecule(gene name synonym)|uniprotkb:Putative adenosylhomocysteinase 2(gene name synonym)|uniprotkb:"IP(3)Rs binding protein released with IP(3)"(gene name synonym)|uniprotkb:IRBIT(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510621|imex:IM-12079-56 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0016579"(protein deubiquitination)|interpro:IPR006155(Machado-Joseph disease protein MJD)|interpro:IPR040053|refseq:NP_001257569.1 refseq:NP_001229602.1|refseq:NP_001229603.1|refseq:NP_001229604.1|refseq:NP_001229605.1|refseq:NP_006612.2|ensembl:ENSG00000168710(gene)|ensembl:ENST00000369799(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006378"(mRNA polyadenylation)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0006730"(one-carbon metabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0010765"(positive regulation of sodium ion transport)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0031440"(regulation of mRNA 3'-end processing)|go:"GO:0032412"(regulation of ion transmembrane transporter activity)|go:"GO:0033353"(S-adenosylmethionine cycle)|go:"GO:0038166"(angiotensin-activated signaling pathway)|go:"GO:0042045"(epithelial fluid transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0044070"(regulation of anion transport)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0051592"(response to calcium ion)|go:"GO:0070062"(extracellular exosome)|go:"GO:1990456"(mitochondrion-endoplasmic reticulum membrane tethering)|interpro:IPR000043(S-adenosyl-L-homocysteine hydrolase)|interpro:IPR015878(S-adenosyl-L-homocysteine hydrolase, NAD binding)|interpro:IPR020082|interpro:IPR036291|interpro:IPR042172|mint:O43865|rcsb pdb:3MTG|reactome:R-HSA-112043|reactome:R-HSA-1489509|reactome:R-HSA-2029485|reactome:R-HSA-2871809|reactome:R-HSA-422356|reactome:R-HSA-5218921|reactome:R-HSA-5578775|reactome:R-HSA-5607763|reactome:R-HSA-9664323|reactome:R-HSA-983695 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:YMdnfXIXV0dPityr5zlAu2wy+yM9606 rogid:uwZ+P9SdKadoVn01p/b8qHp6egk9606 intact-crc:DB1D15B78D9DA6F5|rigid:ARf3Zo8Xq9YQl01z/wGuqg0FS2M false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q7Z7N5 uniprotkb:Q2T9J0 intact:EBI-2510617 intact:EBI-2510623|ensembl:ENSP00000287078|uniprotkb:Q8N6H2|uniprotkb:Q5SQU1|uniprotkb:Q96AR5|uniprotkb:Q5SQT4 psi-mi:q7z7n5_human(display_long)|uniprotkb:JOSD2(gene name)|psi-mi:JOSD2(display_short) psi-mi:tysd1_human(display_long)|uniprotkb:TYSND1(gene name)|psi-mi:TYSND1(display_short)|uniprotkb:Trypsin domain-containing protein 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510621|imex:IM-12079-56 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0016579"(protein deubiquitination)|interpro:IPR006155(Machado-Joseph disease protein MJD)|interpro:IPR040053|refseq:NP_001257569.1 ensembl:ENSG00000156521(gene)|ensembl:ENST00000287078(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005777"(peroxisome)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0016020"(membrane)|go:"GO:0016485"(protein processing)|go:"GO:0031998"(regulation of fatty acid beta-oxidation)|go:"GO:0042802"(identical protein binding)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR017345(Peptidase S1B, Tysnd1)|interpro:IPR039245|reactome:R-HSA-9033241|reactome:R-HSA-9033500|go:"GO:0004252"(serine-type endopeptidase activity)|refseq:NP_001035363.1|refseq:NP_775826.2 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:YMdnfXIXV0dPityr5zlAu2wy+yM9606 rogid:nfBCzADhPAnpbY6GasKVCOaZjjs9606 intact-crc:DB1D15B78D9DA6F5|rigid:ARf3Zo8Xq9YQl01z/wGuqg0FS2M false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q7Z7N5 uniprotkb:Q96HN2 intact:EBI-2510617 intact:EBI-1056923|uniprotkb:O94917|uniprotkb:B4DIZ5|uniprotkb:D9N155|ensembl:ENSP00000315931 psi-mi:q7z7n5_human(display_long)|uniprotkb:JOSD2(gene name)|psi-mi:JOSD2(display_short) psi-mi:sahh3_human(display_long)|uniprotkb:AHCYL2(gene name)|psi-mi:AHCYL2(display_short)|uniprotkb:KIAA0828(gene name synonym)|uniprotkb:S-adenosyl-L-homocysteine hydrolase 3(gene name synonym)|uniprotkb:S-adenosylhomocysteine hydrolase-like protein 2(gene name synonym)|uniprotkb:"IP(3)Rs binding protein released with IP(3) 2"(gene name synonym)|uniprotkb:Long-IRBIT(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510621|imex:IM-12079-56 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0016579"(protein deubiquitination)|interpro:IPR006155(Machado-Joseph disease protein MJD)|interpro:IPR040053|refseq:NP_001257569.1 refseq:NP_001124192.1|refseq:NP_001124194.2|refseq:NP_001124195.1|refseq:NP_056143.1|ensembl:ENSG00000158467(gene)|ensembl:ENST00000325006(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006730"(one-carbon metabolic process)|go:"GO:0016787"(hydrolase activity)|go:"GO:0033353"(S-adenosylmethionine cycle)|go:"GO:0043005"(neuron projection)|interpro:IPR000043(S-adenosyl-L-homocysteine hydrolase)|interpro:IPR015878(S-adenosyl-L-homocysteine hydrolase, NAD binding)|interpro:IPR020082|interpro:IPR036291|interpro:IPR042172|rcsb pdb:3GVP|reactome:R-HSA-425381 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:YMdnfXIXV0dPityr5zlAu2wy+yM9606 rogid:OOrDmlSeGOWqnAhYQcNa4tF5pk09606 intact-crc:DB1D15B78D9DA6F5|rigid:ARf3Zo8Xq9YQl01z/wGuqg0FS2M false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q7Z7N5 uniprotkb:O14582 intact:EBI-2510617 intact:EBI-744565|uniprotkb:Q9HD16|uniprotkb:A6NEG0 psi-mi:q7z7n5_human(display_long)|uniprotkb:JOSD2(gene name)|psi-mi:JOSD2(display_short) psi-mi:tppc2_human(display_long)|uniprotkb:Sedlin(gene name synonym)|uniprotkb:MBP-1-interacting protein 2A(gene name synonym)|uniprotkb:TRAPPC2(gene name)|psi-mi:TRAPPC2(display_short)|uniprotkb:SEDL(gene name synonym)|uniprotkb:TRAPPC2P1(gene name)|psi-mi:TRAPPC2P1(display_short)|uniprotkb:SEDLP(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510621|imex:IM-12079-56 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0016579"(protein deubiquitination)|interpro:IPR006155(Machado-Joseph disease protein MJD)|interpro:IPR040053|refseq:NP_001257569.1 ipi:IPI00940542|go:"GO:0008134"(transcription factor binding)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0001501"(skeletal system development)|interpro:IPR006722(Sedlin)|refseq:NP_001011658.1|refseq:NP_055378.1|ensembl:ENSG00000196459|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|ipi:IPI00005119|go:"GO:0048471"(perinuclear region of cytoplasm)|interpro:IPR011012(Longin-like)|go:"GO:0006351"(transcription, DNA-templated) psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:YMdnfXIXV0dPityr5zlAu2wy+yM9606 rogid:9EuAomPvI2WFJ43aV3V15XuHjTE9606 intact-crc:DB1D15B78D9DA6F5|rigid:ARf3Zo8Xq9YQl01z/wGuqg0FS2M false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H5J8 uniprotkb:Q53T94 intact:EBI-716128|uniprotkb:Q6I9Y6|ensembl:ENSP00000314971|ensembl:ENSP00000410409|ensembl:ENSP00000435087 intact:EBI-1560239|uniprotkb:Q15574|uniprotkb:Q8WVC3|uniprotkb:B4DI42|uniprotkb:F8WD72|ensembl:ENSP00000263663 psi-mi:taf1d_human(display_long)|uniprotkb:RNA polymerase I-specific TBP-associated factor 41 kDa(gene name synonym)|uniprotkb:TAF1D(gene name)|psi-mi:TAF1D(display_short)|uniprotkb:JOSD3(gene name synonym)|uniprotkb:TATA box-binding protein-associated factor 1D(gene name synonym)|uniprotkb:Transcription initiation factor SL1/TIF-IB subunit D(gene name synonym) psi-mi:taf1b_human(display_long)|uniprotkb:TATA box-binding protein-associated factor 1B(gene name synonym)|uniprotkb:Transcription initiation factor SL1/TIF-IB subunit B(gene name synonym)|uniprotkb:RNA polymerase I-specific TBP-associated factor 63 kDa(gene name synonym)|uniprotkb:TAF1B(gene name)|psi-mi:TAF1B(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510669|imex:IM-12079-6 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_077021.1|ensembl:ENSG00000166012(gene)|ensembl:ENST00000323981(transcript)|ensembl:ENST00000448108(transcript)|ensembl:ENST00000526015(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005668"(RNA polymerase transcription factor SL1 complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0034451"(centriolar satellite)|go:"GO:0042802"(identical protein binding)|go:"GO:0072686"(mitotic spindle)|interpro:IPR027976|reactome:R-HSA-427359|reactome:R-HSA-427413|reactome:R-HSA-5250924|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73863 refseq:NP_005671.2|refseq:NP_001305905.1|ensembl:ENSG00000115750(gene)|ensembl:ENST00000263663(transcript)|go:"GO:0001164"(RNA polymerase I core promoter sequence-specific DNA binding)|go:"GO:0001188"(RNA polymerase I preinitiation complex assembly)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005668"(RNA polymerase transcription factor SL1 complex)|go:"GO:0005730"(nucleolus)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0017025"(TBP-class protein binding)|go:"GO:0042790"(nucleolar large rRNA transcription by RNA polymerase I)|go:"GO:0046872"(metal ion binding)|go:"GO:0070860"(RNA polymerase I core factor complex)|interpro:IPR021752|interpro:IPR033599|mint:Q53T94|reactome:R-HSA-427359|reactome:R-HSA-427413|reactome:R-HSA-5250924|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73863 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/01/23 rogid:n8Hb6nlOaMdKQ4nHySrsHDWYiIE9606 rogid:nYrFuCrXHEM0PC8bF8G5OjDiiT49606 intact-crc:0B3374381A3BC871|rigid:Fq9Ht+CDowoae44lyk+ICXX4bWM false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H5J8 uniprotkb:O15160 intact:EBI-716128|uniprotkb:Q6I9Y6|ensembl:ENSP00000314971|ensembl:ENSP00000410409|ensembl:ENSP00000435087 intact:EBI-1055079|uniprotkb:O75395|uniprotkb:Q5JTE3|ensembl:ENSP00000496044 psi-mi:taf1d_human(display_long)|uniprotkb:RNA polymerase I-specific TBP-associated factor 41 kDa(gene name synonym)|uniprotkb:TAF1D(gene name)|psi-mi:TAF1D(display_short)|uniprotkb:JOSD3(gene name synonym)|uniprotkb:TATA box-binding protein-associated factor 1D(gene name synonym)|uniprotkb:Transcription initiation factor SL1/TIF-IB subunit D(gene name synonym) psi-mi:rpac1_human(display_long)|uniprotkb:DNA-directed RNA polymerases I and III 40 kDa polypeptide(gene name synonym)|uniprotkb:RPC40(gene name synonym)|uniprotkb:AC40(gene name synonym)|uniprotkb:RPA39(gene name synonym)|uniprotkb:POLR1C(gene name)|psi-mi:POLR1C(display_short)|uniprotkb:POLR1E(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510669|imex:IM-12079-6 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_077021.1|ensembl:ENSG00000166012(gene)|ensembl:ENST00000323981(transcript)|ensembl:ENST00000448108(transcript)|ensembl:ENST00000526015(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005668"(RNA polymerase transcription factor SL1 complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0034451"(centriolar satellite)|go:"GO:0042802"(identical protein binding)|go:"GO:0072686"(mitotic spindle)|interpro:IPR027976|reactome:R-HSA-427359|reactome:R-HSA-427413|reactome:R-HSA-5250924|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73863 refseq:NP_001305805.1|refseq:NP_976035.1|ensembl:ENSG00000171453(gene)|ensembl:ENST00000642195(transcript)|go:"GO:0001054"(RNA polymerase I activity)|go:"GO:0001056"(RNA polymerase III activity)|go:"GO:0003677"(DNA binding)|go:"GO:0003899"(DNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005666"(RNA polymerase III complex)|go:"GO:0005736"(RNA polymerase I complex)|go:"GO:0005829"(cytosol)|go:"GO:0006360"(transcription by RNA polymerase I)|go:"GO:0046983"(protein dimerization activity)|interpro:IPR001514(DNA-directed RNA polymerase, 30-40 kDa subunit, conserved site)|interpro:IPR011262(DNA-directed RNA polymerase, insert)|interpro:IPR011263(DNA-directed RNA polymerase, RpoA/D/Rpb3-type)|interpro:IPR033901|interpro:IPR036603|interpro:IPR036643|mint:O15160|rcsb pdb:7A6H|rcsb pdb:7AE1|rcsb pdb:7AE3|rcsb pdb:7AEA|rcsb pdb:7AST|rcsb pdb:7D58|rcsb pdb:7D59|rcsb pdb:7DN3|rcsb pdb:7DU2|reactome:R-HSA-1834949|reactome:R-HSA-427413|reactome:R-HSA-5250924|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73780|reactome:R-HSA-73863|reactome:R-HSA-73980|reactome:R-HSA-749476|reactome:R-HSA-76061|reactome:R-HSA-76066|reactome:R-HSA-76071|dip:DIP-27587N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/01/23 rogid:n8Hb6nlOaMdKQ4nHySrsHDWYiIE9606 rogid:xSIuJ9kjLRZ6Vc9EnLdvX/CBJKU9606 intact-crc:0B3374381A3BC871|rigid:Fq9Ht+CDowoae44lyk+ICXX4bWM false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H5J8 intact:EBI-2509386 intact:EBI-716128|uniprotkb:Q6I9Y6|ensembl:ENSP00000314971|ensembl:ENSP00000410409|ensembl:ENSP00000435087 uniparc:UPI0000DD78B9 psi-mi:taf1d_human(display_long)|uniprotkb:RNA polymerase I-specific TBP-associated factor 41 kDa(gene name synonym)|uniprotkb:TAF1D(gene name)|psi-mi:TAF1D(display_short)|uniprotkb:JOSD3(gene name synonym)|uniprotkb:TATA box-binding protein-associated factor 1D(gene name synonym)|uniprotkb:Transcription initiation factor SL1/TIF-IB subunit D(gene name synonym) psi-mi:ipi00455427(display_short)|psi-mi:EBI-2509386(display_long) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510669|imex:IM-12079-6 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_077021.1|ensembl:ENSG00000166012(gene)|ensembl:ENST00000323981(transcript)|ensembl:ENST00000448108(transcript)|ensembl:ENST00000526015(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005668"(RNA polymerase transcription factor SL1 complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0034451"(centriolar satellite)|go:"GO:0042802"(identical protein binding)|go:"GO:0072686"(mitotic spindle)|interpro:IPR027976|reactome:R-HSA-427359|reactome:R-HSA-427413|reactome:R-HSA-5250924|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73863 - psi-mi:"MI:0469"(intact) - no-uniprot-update:An amino acid sequence which is not represented in UniProt figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/01/23 rogid:n8Hb6nlOaMdKQ4nHySrsHDWYiIE9606 rogid:TqeMY2L6a5nopo9mvg/ayKhEtDU9606 intact-crc:0B3374381A3BC871|rigid:Fq9Ht+CDowoae44lyk+ICXX4bWM false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H5J8 uniprotkb:Q15572 intact:EBI-716128|uniprotkb:Q6I9Y6|ensembl:ENSP00000314971|ensembl:ENSP00000410409|ensembl:ENSP00000435087 intact:EBI-2510659|ensembl:ENSP00000455265|uniprotkb:Q59F67|uniprotkb:B7Z5K5|uniprotkb:B7Z5S4|uniprotkb:B7Z9L7|uniprotkb:B7Z908|uniprotkb:Q8N6V3 psi-mi:taf1d_human(display_long)|uniprotkb:RNA polymerase I-specific TBP-associated factor 41 kDa(gene name synonym)|uniprotkb:TAF1D(gene name)|psi-mi:TAF1D(display_short)|uniprotkb:JOSD3(gene name synonym)|uniprotkb:TATA box-binding protein-associated factor 1D(gene name synonym)|uniprotkb:Transcription initiation factor SL1/TIF-IB subunit D(gene name synonym) psi-mi:taf1c_human(display_long)|uniprotkb:TAF1C(gene name)|psi-mi:TAF1C(display_short)|uniprotkb:Transcription initiation factor SL1/TIF-IB subunit C(gene name synonym)|uniprotkb:TATA box-binding protein-associated factor 1C(gene name synonym)|uniprotkb:RNA polymerase I-specific TBP-associated factor 110 kDa(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510669|imex:IM-12079-6 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_077021.1|ensembl:ENSG00000166012(gene)|ensembl:ENST00000323981(transcript)|ensembl:ENST00000448108(transcript)|ensembl:ENST00000526015(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005668"(RNA polymerase transcription factor SL1 complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0034451"(centriolar satellite)|go:"GO:0042802"(identical protein binding)|go:"GO:0072686"(mitotic spindle)|interpro:IPR027976|reactome:R-HSA-427359|reactome:R-HSA-427413|reactome:R-HSA-5250924|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73863 ensembl:ENSG00000103168(gene)|ensembl:ENST00000567759(transcript)|go:"GO:0001164"(RNA polymerase I core promoter sequence-specific DNA binding)|go:"GO:0001181"(RNA polymerase I general transcription initiation factor activity)|go:"GO:0001650"(fibrillar center)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006360"(transcription by RNA polymerase I)|go:"GO:0006361"(transcription initiation from RNA polymerase I promoter)|go:"GO:0006366"(transcription by RNA polymerase II)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR036322|interpro:IPR038801|mint:Q15572|reactome:R-HSA-427359|reactome:R-HSA-427413|reactome:R-HSA-5250924|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73863|refseq:NP_001230086.1|refseq:NP_001230087.1|refseq:NP_001230088.1|refseq:NP_005670.3|refseq:NP_001230085.1|refseq:NP_647610.2|refseq:XP_005256283.1|refseq:XP_016879334.1|refseq:XP_016879337.1|dip:DIP-269N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/01/23 rogid:n8Hb6nlOaMdKQ4nHySrsHDWYiIE9606 rogid:m2f2Ck6oSvfJA8AyIpjSn0Y+k0w9606 intact-crc:0B3374381A3BC871|rigid:Fq9Ht+CDowoae44lyk+ICXX4bWM false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H5J8 uniprotkb:P20226 intact:EBI-716128|uniprotkb:Q6I9Y6|ensembl:ENSP00000314971|ensembl:ENSP00000410409|ensembl:ENSP00000435087 intact:EBI-355371|uniprotkb:Q16845|uniprotkb:Q9UC02|intact:EBI-1056192|uniprotkb:Q6IBM6|ensembl:ENSP00000230354|ensembl:ENSP00000375942|intact:EBI-11019728|uniprotkb:B4E3B3|uniprotkb:F5H869 psi-mi:taf1d_human(display_long)|uniprotkb:RNA polymerase I-specific TBP-associated factor 41 kDa(gene name synonym)|uniprotkb:TAF1D(gene name)|psi-mi:TAF1D(display_short)|uniprotkb:JOSD3(gene name synonym)|uniprotkb:TATA box-binding protein-associated factor 1D(gene name synonym)|uniprotkb:Transcription initiation factor SL1/TIF-IB subunit D(gene name synonym) psi-mi:tbp_human(display_long)|uniprotkb:TBP(gene name)|psi-mi:TBP(display_short)|uniprotkb:TF2D(gene name synonym)|uniprotkb:TFIID(gene name synonym)|uniprotkb:GTF2D1(gene name synonym)|uniprotkb:TATA-box factor(gene name synonym)|uniprotkb:TATA-binding factor(gene name synonym)|uniprotkb:TATA sequence-binding protein(gene name synonym)|uniprotkb:Transcription initiation factor TFIID TBP subunit(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510669|imex:IM-12079-6 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_077021.1|ensembl:ENSG00000166012(gene)|ensembl:ENST00000323981(transcript)|ensembl:ENST00000448108(transcript)|ensembl:ENST00000526015(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005668"(RNA polymerase transcription factor SL1 complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0034451"(centriolar satellite)|go:"GO:0042802"(identical protein binding)|go:"GO:0072686"(mitotic spindle)|interpro:IPR027976|reactome:R-HSA-427359|reactome:R-HSA-427413|reactome:R-HSA-5250924|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73863 refseq:NP_001165556.1|refseq:NP_003185.1|ensembl:ENSP00000230354|ensembl:ENSP00000375942|ensembl:ENST00000540980|ensembl:ENSP00000442132|ensembl:ENSG00000112592(gene)|ensembl:ENST00000230354(transcript)|ensembl:ENST00000392092(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000791"(euchromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0000995"(RNA polymerase III general transcription initiation factor activity)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0001091"(RNA polymerase II general transcription initiation factor binding)|go:"GO:0001093"(TFIIB-class transcription factor binding)|go:"GO:0001939"(female pronucleus)|go:"GO:0001940"(male pronucleus)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005669"(transcription factor TFIID complex)|go:"GO:0005672"(transcription factor TFIIA complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006352"(DNA-templated transcription, initiation)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0006383"(transcription by RNA polymerase III)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016251"(RNA polymerase II general transcription initiation factor activity)|go:"GO:0017162"(aryl hydrocarbon receptor binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051123"(RNA polymerase II preinitiation complex assembly)|go:"GO:0097550"(transcription preinitiation complex)|go:"GO:0140223"(general transcription initiation factor activity)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR000814(TATA-box binding)|interpro:IPR012295(Beta2-adaptin/TATA-box binding, C-terminal)|interpro:IPR030491|interpro:IPR033710|mint:P20226|rcsb pdb:1C9B|rcsb pdb:1CDW|rcsb pdb:1JFI|rcsb pdb:1NVP|rcsb pdb:1TGH|rcsb pdb:4ROC|rcsb pdb:4ROD|rcsb pdb:4ROE|rcsb pdb:5FUR|rcsb pdb:5IY6|rcsb pdb:5IY7|rcsb pdb:5IY8|rcsb pdb:5IY9|rcsb pdb:5IYA|rcsb pdb:5IYB|rcsb pdb:5IYC|rcsb pdb:5IYD|rcsb pdb:5N9G|rcsb pdb:6MZD|rcsb pdb:6MZL|rcsb pdb:6MZM|rcsb pdb:6O9L|rcsb pdb:7EDX|rcsb pdb:7EG7|rcsb pdb:7EG8|rcsb pdb:7EG9|rcsb pdb:7EGA|rcsb pdb:7EGB|rcsb pdb:7EGC|rcsb pdb:7EGD|rcsb pdb:7EGE|rcsb pdb:7EGF|rcsb pdb:7EGI|rcsb pdb:7EGJ|rcsb pdb:7ENA|rcsb pdb:7ENC|rcsb pdb:7LBM|rcsb pdb:7NVR|rcsb pdb:7NVS|rcsb pdb:7NVT|rcsb pdb:7NVU|rcsb pdb:7NVY|rcsb pdb:7NVZ|rcsb pdb:7NW0|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-427359|reactome:R-HSA-427413|reactome:R-HSA-5250924|reactome:R-HSA-674695|reactome:R-HSA-6804756|reactome:R-HSA-6807505|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-73863|reactome:R-HSA-749476|reactome:R-HSA-75953|reactome:R-HSA-76042|reactome:R-HSA-76061|reactome:R-HSA-76066|reactome:R-HSA-76071|reactome:R-HSA-9018519|dip:DIP-1078N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/01/23 rogid:n8Hb6nlOaMdKQ4nHySrsHDWYiIE9606 rogid:tH4ckPOwO4Icr1YsnJ1Ck/6Cgmo9606 intact-crc:0B3374381A3BC871|rigid:Fq9Ht+CDowoae44lyk+ICXX4bWM false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H5J8 uniprotkb:Q15573 intact:EBI-716128|uniprotkb:Q6I9Y6|ensembl:ENSP00000314971|ensembl:ENSP00000410409|ensembl:ENSP00000435087 intact:EBI-2510647|uniprotkb:Q9NWA1|uniprotkb:B2RDZ8|uniprotkb:D3DTB7|ensembl:ENSP00000327072|ensembl:ENSP00000339976 psi-mi:taf1d_human(display_long)|uniprotkb:RNA polymerase I-specific TBP-associated factor 41 kDa(gene name synonym)|uniprotkb:TAF1D(gene name)|psi-mi:TAF1D(display_short)|uniprotkb:JOSD3(gene name synonym)|uniprotkb:TATA box-binding protein-associated factor 1D(gene name synonym)|uniprotkb:Transcription initiation factor SL1/TIF-IB subunit D(gene name synonym) psi-mi:taf1a_human(display_long)|uniprotkb:TAF1A(gene name)|psi-mi:TAF1A(display_short)|uniprotkb:Transcription initiation factor SL1/TIF-IB subunit A(gene name synonym)|uniprotkb:TATA box-binding protein-associated factor 1A(gene name synonym)|uniprotkb:RNA polymerase I-specific TBP-associated factor 48 kDa(gene name synonym)|uniprotkb:Transcription factor SL1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510669|imex:IM-12079-6 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_077021.1|ensembl:ENSG00000166012(gene)|ensembl:ENST00000323981(transcript)|ensembl:ENST00000448108(transcript)|ensembl:ENST00000526015(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005668"(RNA polymerase transcription factor SL1 complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0034451"(centriolar satellite)|go:"GO:0042802"(identical protein binding)|go:"GO:0072686"(mitotic spindle)|interpro:IPR027976|reactome:R-HSA-427359|reactome:R-HSA-427413|reactome:R-HSA-5250924|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73863 refseq:NP_647603.1|refseq:NP_001188465.1|refseq:NP_005672.1|refseq:XP_006711676.1|refseq:XP_016858248.1|refseq:XP_016858249.1|ensembl:ENSG00000143498(gene)|ensembl:ENST00000350027(transcript)|ensembl:ENST00000352967(transcript)|go:"GO:0000120"(RNA polymerase I transcription regulator complex)|go:"GO:0003677"(DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006360"(transcription by RNA polymerase I)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0015630"(microtubule cytoskeleton)|interpro:IPR016629("RNA polymerase I, subunit A (TATA-binding protein-associated factor)")|interpro:IPR039495|mint:Q15573|reactome:R-HSA-427359|reactome:R-HSA-427413|reactome:R-HSA-5250924|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73863 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/01/23 rogid:n8Hb6nlOaMdKQ4nHySrsHDWYiIE9606 rogid:xWosq238liTnXTjyWix1mFyOf5Q9606 intact-crc:0B3374381A3BC871|rigid:Fq9Ht+CDowoae44lyk+ICXX4bWM false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H5J8 uniprotkb:P19784 intact:EBI-716128|uniprotkb:Q6I9Y6|ensembl:ENSP00000314971|ensembl:ENSP00000410409|ensembl:ENSP00000435087 intact:EBI-347451|ensembl:ENSP00000262506 psi-mi:taf1d_human(display_long)|uniprotkb:RNA polymerase I-specific TBP-associated factor 41 kDa(gene name synonym)|uniprotkb:TAF1D(gene name)|psi-mi:TAF1D(display_short)|uniprotkb:JOSD3(gene name synonym)|uniprotkb:TATA box-binding protein-associated factor 1D(gene name synonym)|uniprotkb:Transcription initiation factor SL1/TIF-IB subunit D(gene name synonym) psi-mi:csk22_human(display_long)|uniprotkb:CSNK2A2(gene name)|psi-mi:CSNK2A2(display_short)|uniprotkb:CK2A2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510669|imex:IM-12079-6 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_077021.1|ensembl:ENSG00000166012(gene)|ensembl:ENST00000323981(transcript)|ensembl:ENST00000448108(transcript)|ensembl:ENST00000526015(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005668"(RNA polymerase transcription factor SL1 complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0034451"(centriolar satellite)|go:"GO:0042802"(identical protein binding)|go:"GO:0072686"(mitotic spindle)|interpro:IPR027976|reactome:R-HSA-427359|reactome:R-HSA-427413|reactome:R-HSA-5250924|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73863 refseq:NP_001887.1|dip:DIP-318N|ensembl:ENSG00000070770(gene)|ensembl:ENST00000262506(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005956"(protein kinase CK2 complex)|go:"GO:0006915"(apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0007283"(spermatogenesis)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0097421"(liver regeneration)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1905818"(regulation of chromosome separation)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P19784|rcsb pdb:3E3B|rcsb pdb:3OFM|rcsb pdb:3U87|rcsb pdb:5M4U|rcsb pdb:5M56|rcsb pdb:5OOI|rcsb pdb:5Y9M|rcsb pdb:5YF9|rcsb pdb:5YWM|rcsb pdb:6HMB|rcsb pdb:6HMC|rcsb pdb:6HMD|rcsb pdb:6HMQ|rcsb pdb:6L20|rcsb pdb:6QY8|rcsb pdb:6QY9|rcsb pdb:6TE2|rcsb pdb:6TEW|rcsb pdb:6TGU|rcsb pdb:7A1B|rcsb pdb:7A1Z|rcsb pdb:7A22|rcsb pdb:7A2H|reactome:R-HSA-1483191|reactome:R-HSA-201688|reactome:R-HSA-2514853|reactome:R-HSA-445144|reactome:R-HSA-6804756|reactome:R-HSA-6814122|reactome:R-HSA-8932339|reactome:R-HSA-8934903|reactome:R-HSA-8939243|reactome:R-HSA-8948751 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/01/23 rogid:n8Hb6nlOaMdKQ4nHySrsHDWYiIE9606 rogid:SIekW2yzNePP9hLKW7OHNFBwNck9606 intact-crc:0B3374381A3BC871|rigid:Fq9Ht+CDowoae44lyk+ICXX4bWM false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H5J8 uniprotkb:Q9NQ55 intact:EBI-716128|uniprotkb:Q6I9Y6|ensembl:ENSP00000314971|ensembl:ENSP00000410409|ensembl:ENSP00000435087 intact:EBI-1048540|uniprotkb:Q9BW97|uniprotkb:Q9H170|uniprotkb:C9J3F9|ensembl:ENSP00000253107 psi-mi:taf1d_human(display_long)|uniprotkb:RNA polymerase I-specific TBP-associated factor 41 kDa(gene name synonym)|uniprotkb:TAF1D(gene name)|psi-mi:TAF1D(display_short)|uniprotkb:JOSD3(gene name synonym)|uniprotkb:TATA box-binding protein-associated factor 1D(gene name synonym)|uniprotkb:Transcription initiation factor SL1/TIF-IB subunit D(gene name synonym) psi-mi:ssf1_human(display_long)|uniprotkb:Peter Pan homolog(gene name synonym)|uniprotkb:PPAN(gene name)|psi-mi:PPAN(display_short)|uniprotkb:SSF1(gene name synonym)|uniprotkb:BXDC3(gene name synonym)|uniprotkb:Brix domain-containing protein 3(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510669|imex:IM-12079-6 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_077021.1|ensembl:ENSG00000166012(gene)|ensembl:ENST00000323981(transcript)|ensembl:ENST00000448108(transcript)|ensembl:ENST00000526015(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005668"(RNA polymerase transcription factor SL1 complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0034451"(centriolar satellite)|go:"GO:0042802"(identical protein binding)|go:"GO:0072686"(mitotic spindle)|interpro:IPR027976|reactome:R-HSA-427359|reactome:R-HSA-427413|reactome:R-HSA-5250924|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73863 refseq:NP_001035754.1|refseq:NP_064615.3|ensembl:ENSG00000130810(gene)|ensembl:ENST00000253107(transcript)|go:"GO:0000027"(ribosomal large subunit assembly)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0006364"(rRNA processing)|go:"GO:0019843"(rRNA binding)|go:"GO:0030687"(preribosome, large subunit precursor)|interpro:IPR007109(Brix)|mint:Q9NQ55 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/01/23 rogid:n8Hb6nlOaMdKQ4nHySrsHDWYiIE9606 rogid:wIgMQj/xJrj5eExsyZD6BeamQOQ9606 intact-crc:0B3374381A3BC871|rigid:Fq9Ht+CDowoae44lyk+ICXX4bWM false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H5J8 uniprotkb:Q3B726 intact:EBI-716128|uniprotkb:Q6I9Y6|ensembl:ENSP00000314971|ensembl:ENSP00000410409|ensembl:ENSP00000435087 intact:EBI-1642554|uniprotkb:A0PJ45|uniprotkb:B7Z724|ensembl:ENSP00000222567 psi-mi:taf1d_human(display_long)|uniprotkb:RNA polymerase I-specific TBP-associated factor 41 kDa(gene name synonym)|uniprotkb:TAF1D(gene name)|psi-mi:TAF1D(display_short)|uniprotkb:JOSD3(gene name synonym)|uniprotkb:TATA box-binding protein-associated factor 1D(gene name synonym)|uniprotkb:Transcription initiation factor SL1/TIF-IB subunit D(gene name synonym) psi-mi:rpa43_human(display_long)|uniprotkb:POLR1F(gene name)|psi-mi:POLR1F(display_short)|uniprotkb:DNA-directed RNA polymerase I subunit F(gene name synonym)|uniprotkb:TWISTNB(gene name synonym)|uniprotkb:Twist neighbor protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510669|imex:IM-12079-6 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_077021.1|ensembl:ENSG00000166012(gene)|ensembl:ENST00000323981(transcript)|ensembl:ENST00000448108(transcript)|ensembl:ENST00000526015(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005668"(RNA polymerase transcription factor SL1 complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0034451"(centriolar satellite)|go:"GO:0042802"(identical protein binding)|go:"GO:0072686"(mitotic spindle)|interpro:IPR027976|reactome:R-HSA-427359|reactome:R-HSA-427413|reactome:R-HSA-5250924|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73863 refseq:NP_001002926.1|ensembl:ENSG00000105849(gene)|ensembl:ENST00000222567(transcript)|go:"GO:0003899"(DNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005736"(RNA polymerase I complex)|interpro:IPR036898|interpro:IPR041178|interpro:IPR041901|reactome:R-HSA-427413|reactome:R-HSA-5250924|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73863 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/01/23 rogid:n8Hb6nlOaMdKQ4nHySrsHDWYiIE9606 rogid:Dh5USsPRiE7XJFM90H43I/IzodY9606 intact-crc:0B3374381A3BC871|rigid:Fq9Ht+CDowoae44lyk+ICXX4bWM false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H5J8 uniprotkb:P61289 intact:EBI-716128|uniprotkb:Q6I9Y6|ensembl:ENSP00000314971|ensembl:ENSP00000410409|ensembl:ENSP00000435087 intact:EBI-355546|uniprotkb:O35563|uniprotkb:P97373|uniprotkb:Q12920|uniprotkb:Q13172|uniprotkb:Q9BQD9|uniprotkb:A8K9A3|ensembl:ENSP00000466794 psi-mi:taf1d_human(display_long)|uniprotkb:RNA polymerase I-specific TBP-associated factor 41 kDa(gene name synonym)|uniprotkb:TAF1D(gene name)|psi-mi:TAF1D(display_short)|uniprotkb:JOSD3(gene name synonym)|uniprotkb:TATA box-binding protein-associated factor 1D(gene name synonym)|uniprotkb:Transcription initiation factor SL1/TIF-IB subunit D(gene name synonym) psi-mi:psme3_human(display_long)|uniprotkb:PSME3(gene name)|psi-mi:PSME3(display_short)|uniprotkb:Proteasome activator 28 subunit gamma(gene name synonym)|uniprotkb:Activator of multicatalytic protease subunit 3(gene name synonym)|uniprotkb:11S regulator complex subunit gamma(gene name synonym)|uniprotkb:Ki nuclear autoantigen(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510669|imex:IM-12079-6 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_077021.1|ensembl:ENSG00000166012(gene)|ensembl:ENST00000323981(transcript)|ensembl:ENST00000448108(transcript)|ensembl:ENST00000526015(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005668"(RNA polymerase transcription factor SL1 complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0034451"(centriolar satellite)|go:"GO:0042802"(identical protein binding)|go:"GO:0072686"(mitotic spindle)|interpro:IPR027976|reactome:R-HSA-427359|reactome:R-HSA-427413|reactome:R-HSA-5250924|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73863 refseq:NP_005780.2|refseq:NP_789839.1|ensembl:ENSG00000131467(gene)|ensembl:ENST00000590720(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0002039"(p53 binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0008537"(proteasome activator complex)|go:"GO:0010950"(positive regulation of endopeptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0061133"(endopeptidase activator activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR003185(Proteasome activator pa28, REG alpha subunit)|interpro:IPR003186(Proteasome activator pa28, REG beta subunit)|interpro:IPR009077(Proteasome activator pa28, REG alpha/beta subunit)|interpro:IPR036252|interpro:IPR036996|interpro:IPR036997|mint:P61289|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/01/23 rogid:n8Hb6nlOaMdKQ4nHySrsHDWYiIE9606 rogid:6EQY2Kj3Juf++m4eBDzPWMgbC2k9606 intact-crc:0B3374381A3BC871|rigid:Fq9Ht+CDowoae44lyk+ICXX4bWM false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H5J8 uniprotkb:O00410 intact:EBI-716128|uniprotkb:Q6I9Y6|ensembl:ENSP00000314971|ensembl:ENSP00000410409|ensembl:ENSP00000435087 intact:EBI-356424|uniprotkb:O15257|intact:EBI-1105173|uniprotkb:B4DZA0|uniprotkb:Q5T578|uniprotkb:Q86XC7|ensembl:ENSP00000350219|ensembl:ENSP00000418393|ensembl:ENSP00000499125 psi-mi:taf1d_human(display_long)|uniprotkb:RNA polymerase I-specific TBP-associated factor 41 kDa(gene name synonym)|uniprotkb:TAF1D(gene name)|psi-mi:TAF1D(display_short)|uniprotkb:JOSD3(gene name synonym)|uniprotkb:TATA box-binding protein-associated factor 1D(gene name synonym)|uniprotkb:Transcription initiation factor SL1/TIF-IB subunit D(gene name synonym) psi-mi:ipo5_human(display_long)|uniprotkb:IPO5(gene name)|psi-mi:IPO5(display_short)|uniprotkb:KPNB3(gene name synonym)|uniprotkb:RANBP5(gene name synonym)|uniprotkb:Importin subunit beta-3(gene name synonym)|uniprotkb:Karyopherin beta-3(gene name synonym)|uniprotkb:Ran-binding protein 5(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510669|imex:IM-12079-6 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_077021.1|ensembl:ENSG00000166012(gene)|ensembl:ENST00000323981(transcript)|ensembl:ENST00000448108(transcript)|ensembl:ENST00000526015(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005668"(RNA polymerase transcription factor SL1 complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0034451"(centriolar satellite)|go:"GO:0042802"(identical protein binding)|go:"GO:0072686"(mitotic spindle)|interpro:IPR027976|reactome:R-HSA-427359|reactome:R-HSA-427413|reactome:R-HSA-5250924|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73863 refseq:NP_002262.3|refseq:XP_011519389.1|refseq:XP_011519390.1|refseq:XP_011519391.1|refseq:XP_011519392.1|ensembl:ENSG00000065150(gene)|ensembl:ENST00000357602(transcript)|ensembl:ENST00000490680(transcript)|ensembl:ENST00000651721(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005095"(GTPase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005643"(nuclear pore)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006607"(NLS-bearing protein import into nucleus)|go:"GO:0006610"(ribosomal protein import into nucleus)|go:"GO:0008139"(nuclear localization sequence binding)|refseq:XP_005254109.1|refseq:XP_005254110.1|go:"GO:0016020"(membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0061608"(nuclear import signal receptor activity)|go:"GO:0071230"(cellular response to amino acid stimulus)|interpro:IPR000357(HEAT)|interpro:IPR001494(Importin-beta, N-terminal)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR034085|interpro:IPR040122|interpro:IPR040928|interpro:IPR041389|interpro:IPR041653|mint:O00410|rcsb pdb:6XTE|rcsb pdb:6XU2|reactome:R-HSA-192905|refseq:XP_016876051.1|dip:DIP-41042N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/01/23 rogid:n8Hb6nlOaMdKQ4nHySrsHDWYiIE9606 rogid:jBYLvkqyYyWAu1TdCVyCMh9ZHKY9606 intact-crc:0B3374381A3BC871|rigid:Fq9Ht+CDowoae44lyk+ICXX4bWM false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H5J8 uniprotkb:Q9NYV6 intact:EBI-716128|uniprotkb:Q6I9Y6|ensembl:ENSP00000314971|ensembl:ENSP00000410409|ensembl:ENSP00000435087 intact:EBI-2510653|ensembl:ENSP00000198767|ensembl:ENSP00000480743|uniprotkb:B4E0J7|uniprotkb:B4E3T2|uniprotkb:Q3MHU9|uniprotkb:Q9H4F0|uniprotkb:Q6IPL4|uniprotkb:A2RTY9 psi-mi:taf1d_human(display_long)|uniprotkb:RNA polymerase I-specific TBP-associated factor 41 kDa(gene name synonym)|uniprotkb:TAF1D(gene name)|psi-mi:TAF1D(display_short)|uniprotkb:JOSD3(gene name synonym)|uniprotkb:TATA box-binding protein-associated factor 1D(gene name synonym)|uniprotkb:Transcription initiation factor SL1/TIF-IB subunit D(gene name synonym) psi-mi:rrn3_human(display_long)|uniprotkb:RRN3(gene name)|psi-mi:RRN3(display_short)|uniprotkb:TIFIA(gene name synonym)|uniprotkb:Transcription initiation factor IA(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510669|imex:IM-12079-6 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_077021.1|ensembl:ENSG00000166012(gene)|ensembl:ENST00000323981(transcript)|ensembl:ENST00000448108(transcript)|ensembl:ENST00000526015(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005668"(RNA polymerase transcription factor SL1 complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0034451"(centriolar satellite)|go:"GO:0042802"(identical protein binding)|go:"GO:0072686"(mitotic spindle)|interpro:IPR027976|reactome:R-HSA-427359|reactome:R-HSA-427413|reactome:R-HSA-5250924|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73863 ensembl:ENST00000616334(transcript)|go:"GO:0001042"(RNA polymerase I core binding)|go:"GO:0001164"(RNA polymerase I core promoter sequence-specific DNA binding)|go:"GO:0001181"(RNA polymerase I general transcription initiation factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006361"(transcription initiation from RNA polymerase I promoter)|go:"GO:0010976"(positive regulation of neuron projection development)|interpro:IPR007991(RNA polymerase I specific transcription initiation factor RRN3)|mint:Q9NYV6|reactome:R-HSA-73762|reactome:R-HSA-73772|ensembl:ENSG00000085721(gene)|ensembl:ENSG00000278494(gene)|ensembl:ENST00000198767(transcript)|refseq:NP_060897.3 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/01/23 rogid:n8Hb6nlOaMdKQ4nHySrsHDWYiIE9606 rogid:sE9dxyMWq9h1g7+yO4gVOdrfCAo9606 intact-crc:0B3374381A3BC871|rigid:Fq9Ht+CDowoae44lyk+ICXX4bWM false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H5J8 uniprotkb:Q9Y3B9 intact:EBI-716128|uniprotkb:Q6I9Y6|ensembl:ENSP00000314971|ensembl:ENSP00000410409|ensembl:ENSP00000435087 intact:EBI-1055610|intact:EBI-28979625|ensembl:ENSP00000355899 psi-mi:taf1d_human(display_long)|uniprotkb:RNA polymerase I-specific TBP-associated factor 41 kDa(gene name synonym)|uniprotkb:TAF1D(gene name)|psi-mi:TAF1D(display_short)|uniprotkb:JOSD3(gene name synonym)|uniprotkb:TATA box-binding protein-associated factor 1D(gene name synonym)|uniprotkb:Transcription initiation factor SL1/TIF-IB subunit D(gene name synonym) psi-mi:rrp15_human(display_long)|uniprotkb:Ribosomal RNA-processing protein 15(gene name synonym)|uniprotkb:RRP15(gene name)|psi-mi:RRP15(display_short)|uniprotkb:KIAA0507(gene name synonym)|uniprotkb:CGI-115(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510669|imex:IM-12079-6 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_077021.1|ensembl:ENSG00000166012(gene)|ensembl:ENST00000323981(transcript)|ensembl:ENST00000448108(transcript)|ensembl:ENST00000526015(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005668"(RNA polymerase transcription factor SL1 complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0034451"(centriolar satellite)|go:"GO:0042802"(identical protein binding)|go:"GO:0072686"(mitotic spindle)|interpro:IPR027976|reactome:R-HSA-427359|reactome:R-HSA-427413|reactome:R-HSA-5250924|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73863 ensembl:ENSP00000355899|refseq:NP_057136.2|ensembl:ENSG00000067533(gene)|ensembl:ENST00000366932(transcript)|go:"GO:0000460"(maturation of 5.8S rRNA)|go:"GO:0000470"(maturation of LSU-rRNA)|go:"GO:0030687"(preribosome, large subunit precursor)|interpro:IPR012459(Protein of unknown function DUF1665) psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/01/23 rogid:n8Hb6nlOaMdKQ4nHySrsHDWYiIE9606 rogid:EJQFG76HKEYeJ6LwFd5zaUmoScw9606 intact-crc:0B3374381A3BC871|rigid:Fq9Ht+CDowoae44lyk+ICXX4bWM false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H5J8 uniprotkb:Q9H9Y6 intact:EBI-716128|uniprotkb:Q6I9Y6|ensembl:ENSP00000314971|ensembl:ENSP00000410409|ensembl:ENSP00000435087 intact:EBI-355441|uniprotkb:Q6ZRR2|uniprotkb:Q9H9D3|uniprotkb:Q585T5|uniprotkb:B7Z6Y7|uniprotkb:B7Z823|uniprotkb:F5GZX4|uniprotkb:F8W898|uniprotkb:Q2TAM4|ensembl:ENSP00000263331 psi-mi:taf1d_human(display_long)|uniprotkb:RNA polymerase I-specific TBP-associated factor 41 kDa(gene name synonym)|uniprotkb:TAF1D(gene name)|psi-mi:TAF1D(display_short)|uniprotkb:JOSD3(gene name synonym)|uniprotkb:TATA box-binding protein-associated factor 1D(gene name synonym)|uniprotkb:Transcription initiation factor SL1/TIF-IB subunit D(gene name synonym) psi-mi:rpa2_human(display_long)|uniprotkb:POLR1B(gene name)|psi-mi:POLR1B(display_short)|uniprotkb:DNA-directed RNA polymerase I 135 kDa polypeptide(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510669|imex:IM-12079-6 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_077021.1|ensembl:ENSG00000166012(gene)|ensembl:ENST00000323981(transcript)|ensembl:ENST00000448108(transcript)|ensembl:ENST00000526015(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005668"(RNA polymerase transcription factor SL1 complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0034451"(centriolar satellite)|go:"GO:0042802"(identical protein binding)|go:"GO:0072686"(mitotic spindle)|interpro:IPR027976|reactome:R-HSA-427359|reactome:R-HSA-427413|reactome:R-HSA-5250924|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73863 refseq:NP_001131076.1|refseq:NP_061887.2|refseq:NP_001269703.1|refseq:NP_001269705.1|refseq:NP_001269706.1|refseq:NP_001269708.1|refseq:NP_001269701.1|dip:DIP-27538N|interpro:IPR007641(RNA polymerase Rpb2, domain 7)|interpro:IPR007642(RNA polymerase Rpb2, domain 2)|interpro:IPR007644(RNA polymerase, beta subunit, protrusion)|interpro:IPR007645(RNA polymerase Rpb2, domain 3)|interpro:IPR009674(RNA polymerase I, Rpa2 specific)|interpro:IPR014724(RNA polymerase Rpb2, OB-fold)|interpro:IPR015712(DNA-directed RNA polymerase, subunit 2)|interpro:IPR037033|interpro:IPR037034|mint:Q9H9Y6|reactome:R-HSA-427413|reactome:R-HSA-5250924|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73863|interpro:IPR007120(DNA-directed RNA polymerase, subunit 2, domain 6)|interpro:IPR007121(RNA polymerase, beta subunit, conserved site)|ensembl:ENSG00000125630(gene)|ensembl:ENST00000263331(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003899"(DNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005736"(RNA polymerase I complex)|go:"GO:0005829"(cytosol)|go:"GO:0007566"(embryo implantation)|go:"GO:0009303"(rRNA transcription)|go:"GO:0014029"(neural crest formation)|go:"GO:0017126"(nucleologenesis)|go:"GO:0032549"(ribonucleoside binding)|go:"GO:0046872"(metal ion binding) psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/01/23 rogid:n8Hb6nlOaMdKQ4nHySrsHDWYiIE9606 rogid:enAJckjxEU6bE3J3OA5pFREXC3U9606 intact-crc:0B3374381A3BC871|rigid:Fq9Ht+CDowoae44lyk+ICXX4bWM false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H5J8 uniprotkb:O95602 intact:EBI-716128|uniprotkb:Q6I9Y6|ensembl:ENSP00000314971|ensembl:ENSP00000410409|ensembl:ENSP00000435087 intact:EBI-359472|uniprotkb:Q9UEH0|uniprotkb:Q9UFT9|uniprotkb:Q0VG05|uniprotkb:B7Z7T0|uniprotkb:D6W5M0|ensembl:ENSP00000263857 psi-mi:taf1d_human(display_long)|uniprotkb:RNA polymerase I-specific TBP-associated factor 41 kDa(gene name synonym)|uniprotkb:TAF1D(gene name)|psi-mi:TAF1D(display_short)|uniprotkb:JOSD3(gene name synonym)|uniprotkb:TATA box-binding protein-associated factor 1D(gene name synonym)|uniprotkb:Transcription initiation factor SL1/TIF-IB subunit D(gene name synonym) psi-mi:rpa1_human(display_long)|uniprotkb:POLR1A(gene name)|psi-mi:POLR1A(display_short)|uniprotkb:DNA-directed RNA polymerase I subunit A(gene name synonym)|uniprotkb:DNA-directed RNA polymerase I largest subunit(gene name synonym)|uniprotkb:RNA polymerase I 194 kDa subunit(gene name synonym)|uniprotkb:A190(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510669|imex:IM-12079-6 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_077021.1|ensembl:ENSG00000166012(gene)|ensembl:ENST00000323981(transcript)|ensembl:ENST00000448108(transcript)|ensembl:ENST00000526015(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005668"(RNA polymerase transcription factor SL1 complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0034451"(centriolar satellite)|go:"GO:0042802"(identical protein binding)|go:"GO:0072686"(mitotic spindle)|interpro:IPR027976|reactome:R-HSA-427359|reactome:R-HSA-427413|reactome:R-HSA-5250924|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73863 refseq:NP_056240.2|ensembl:ENST00000263857(transcript)|go:"GO:0001054"(RNA polymerase I activity)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005736"(RNA polymerase I complex)|go:"GO:0008270"(zinc ion binding)|go:"GO:1904750"(negative regulation of protein localization to nucleolus)|interpro:IPR000722(RNA polymerase, alpha subunit)|interpro:IPR006592(RNA polymerase, N-terminal)|interpro:IPR007066(RNA polymerase Rpb1, domain 3)|interpro:IPR007080(RNA polymerase Rpb1, domain 1)|interpro:IPR007081(RNA polymerase Rpb1, domain 5)|interpro:IPR007083(RNA polymerase Rpb1, domain 4)|interpro:IPR015699(DNA-directed RNA pol I, largest subunit)|interpro:IPR038120|interpro:IPR042102|mint:O95602|reactome:R-HSA-427413|reactome:R-HSA-5250924|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73863|ensembl:ENSG00000068654(gene)|dip:DIP-27537N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/01/23 rogid:n8Hb6nlOaMdKQ4nHySrsHDWYiIE9606 rogid:EDNwLyujEW01bH48PD19pr3/lgU9606 intact-crc:0B3374381A3BC871|rigid:Fq9Ht+CDowoae44lyk+ICXX4bWM false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H5J8 uniprotkb:P07199 intact:EBI-716128|uniprotkb:Q6I9Y6|ensembl:ENSP00000314971|ensembl:ENSP00000410409|ensembl:ENSP00000435087 intact:EBI-949451|intact:EBI-28970331|ensembl:ENSP00000369075|uniprotkb:Q96EI4 psi-mi:taf1d_human(display_long)|uniprotkb:RNA polymerase I-specific TBP-associated factor 41 kDa(gene name synonym)|uniprotkb:TAF1D(gene name)|psi-mi:TAF1D(display_short)|uniprotkb:JOSD3(gene name synonym)|uniprotkb:TATA box-binding protein-associated factor 1D(gene name synonym)|uniprotkb:Transcription initiation factor SL1/TIF-IB subunit D(gene name synonym) psi-mi:cenpb_human(display_long)|uniprotkb:Centromere protein B(gene name synonym)|uniprotkb:CENPB(gene name)|psi-mi:CENPB(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510669|imex:IM-12079-6 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_077021.1|ensembl:ENSG00000166012(gene)|ensembl:ENST00000323981(transcript)|ensembl:ENST00000448108(transcript)|ensembl:ENST00000526015(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005668"(RNA polymerase transcription factor SL1 complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0034451"(centriolar satellite)|go:"GO:0042802"(identical protein binding)|go:"GO:0072686"(mitotic spindle)|interpro:IPR027976|reactome:R-HSA-427359|reactome:R-HSA-427413|reactome:R-HSA-5250924|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73863 ensembl:ENSP00000369075|ensembl:ENSG00000125817(gene)|ensembl:ENST00000379751(transcript)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000779"(condensed chromosome, centromeric region)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003696"(satellite DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0016604"(nuclear body)|go:"GO:0019237"(centromeric DNA binding)|go:"GO:0043565"(sequence-specific DNA binding)|interpro:IPR004875(CENP-B protein)|interpro:IPR006600(Centromere protein B, helix-turn-helix)|interpro:IPR007889(Helix-turn-helix, Psq)|interpro:IPR009057(Homeodomain-like)|interpro:IPR015115(Centromere protein B dimerisation)|interpro:IPR033062|interpro:IPR034882|mint:P07199|rcsb pdb:1BW6|rcsb pdb:1HLV|rcsb pdb:1UFI|rcsb pdb:6KDR|refseq:NP_001801.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/01/23 rogid:n8Hb6nlOaMdKQ4nHySrsHDWYiIE9606 rogid:+03fJP9KYbjMxvL/JrO0Wj4+MJs9606 intact-crc:0B3374381A3BC871|rigid:Fq9Ht+CDowoae44lyk+ICXX4bWM false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H5J8 uniprotkb:P67870 intact:EBI-716128|uniprotkb:Q6I9Y6|ensembl:ENSP00000314971|ensembl:ENSP00000410409|ensembl:ENSP00000435087 intact:EBI-348169|ensembl:ENSP00000365025|ensembl:ENSP00000365026|ensembl:ENSP00000365042|ensembl:ENSP00000372919|ensembl:ENSP00000372925|ensembl:ENSP00000382980|ensembl:ENSP00000390900|ensembl:ENSP00000391038|ensembl:ENSP00000393756|ensembl:ENSP00000394855|ensembl:ENSP00000395275|ensembl:ENSP00000400188|ensembl:ENSP00000407018|ensembl:ENSP00000407379|ensembl:ENSP00000409510|ensembl:ENSP00000410802|ensembl:ENSP00000411322|ensembl:ENSP00000412520|ensembl:ENSP00000413469|ensembl:ENSP00000415237|ensembl:ENSP00000415303|uniprotkb:P07312|uniprotkb:P13862|uniprotkb:Q4VX47|intact:EBI-3866975|uniprotkb:B0UXA9 psi-mi:taf1d_human(display_long)|uniprotkb:RNA polymerase I-specific TBP-associated factor 41 kDa(gene name synonym)|uniprotkb:TAF1D(gene name)|psi-mi:TAF1D(display_short)|uniprotkb:JOSD3(gene name synonym)|uniprotkb:TATA box-binding protein-associated factor 1D(gene name synonym)|uniprotkb:Transcription initiation factor SL1/TIF-IB subunit D(gene name synonym) psi-mi:csk2b_human(display_long)|uniprotkb:Phosvitin(gene name synonym)|uniprotkb:Protein G5a(gene name synonym)|uniprotkb:CSNK2B(gene name)|psi-mi:CSNK2B(display_short)|uniprotkb:CK2N(gene name synonym)|uniprotkb:G5A(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510669|imex:IM-12079-6 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_077021.1|ensembl:ENSG00000166012(gene)|ensembl:ENST00000323981(transcript)|ensembl:ENST00000448108(transcript)|ensembl:ENST00000526015(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005668"(RNA polymerase transcription factor SL1 complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0034451"(centriolar satellite)|go:"GO:0042802"(identical protein binding)|go:"GO:0072686"(mitotic spindle)|interpro:IPR027976|reactome:R-HSA-427359|reactome:R-HSA-427413|reactome:R-HSA-5250924|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73863 ensembl:ENSG00000204435(gene)|ensembl:ENSG00000230700(gene)|ensembl:ENSG00000206406(gene)|ensembl:ENSG00000232960(gene)|ensembl:ENSG00000224398(gene)|ensembl:ENSG00000224774(gene)|ensembl:ENSG00000228875(gene)|ensembl:ENST00000375882(transcript)|ensembl:ENST00000383427(transcript)|ensembl:ENST00000383433(transcript)|ensembl:ENST00000400110(transcript)|ensembl:ENST00000412802(transcript)|ensembl:ENST00000418230(transcript)|ensembl:ENST00000422567(transcript)|ensembl:ENST00000429633(transcript)|ensembl:ENST00000431476(transcript)|ensembl:ENST00000436169(transcript)|ensembl:ENST00000443673(transcript)|ensembl:ENST00000448596(transcript)|ensembl:ENST00000451917(transcript)|ensembl:ENST00000452985(transcript)|ensembl:ENST00000453234(transcript)|ensembl:ENST00000454382(transcript)|ensembl:ENST00000454511(transcript)|ensembl:ENST00000455161(transcript)|ensembl:ENST00000458330(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0005956"(protein kinase CK2 complex)|go:"GO:0007165"(signal transduction)|ensembl:ENST00000375865(transcript)|ensembl:ENST00000375866(transcript)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016363"(nuclear matrix)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032927"(positive regulation of activin receptor signaling pathway)|go:"GO:0033211"(adiponectin-activated signaling pathway)|go:"GO:0033574"(response to testosterone)|go:"GO:0034622"|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042802"(identical protein binding)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0046872"(metal ion binding)|go:"GO:0051101"(regulation of DNA binding)|go:"GO:0061154"(endothelial tube morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0080163"(regulation of protein serine/threonine phosphatase activity)|go:"GO:0097421"(liver regeneration)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000704(Casein kinase II, regulatory subunit)|interpro:IPR016149(Casein kinase II, regulatory subunit, alpha-helical)|interpro:IPR035991|mint:P67870|rcsb pdb:1DS5|rcsb pdb:1JWH|go:"GO:0008134"(transcription factor binding)|rcsb pdb:1QF8|rcsb pdb:3EED|rcsb pdb:4DGL|rcsb pdb:4MD7|rcsb pdb:4MD8|rcsb pdb:4MD9|rcsb pdb:4NH1|reactome:R-HSA-1483191|reactome:R-HSA-201688|reactome:R-HSA-2514853|reactome:R-HSA-445144|reactome:R-HSA-6798695|reactome:R-HSA-6804756|reactome:R-HSA-6814122|reactome:R-HSA-8932339|reactome:R-HSA-8934903|reactome:R-HSA-8939243|reactome:R-HSA-8948751|rcsb pdb:6Q38|refseq:NP_001311.3|refseq:NP_001269314.1|dip:DIP-131N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/01/23 rogid:n8Hb6nlOaMdKQ4nHySrsHDWYiIE9606 rogid:ZTHJjCqHg2dE7B+WoSU28VSMuPg9606 intact-crc:0B3374381A3BC871|rigid:Fq9Ht+CDowoae44lyk+ICXX4bWM false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H5J8 uniprotkb:P68400 intact:EBI-716128|uniprotkb:Q6I9Y6|ensembl:ENSP00000314971|ensembl:ENSP00000410409|ensembl:ENSP00000435087 intact:EBI-347804|ensembl:ENSP00000217244|ensembl:ENSP00000383076|ensembl:ENSP00000495248|ensembl:ENSP00000495422|ensembl:ENSP00000495902|ensembl:ENSP00000495912|ensembl:ENSP00000495998|ensembl:ENSP00000496569|uniprotkb:P19138|uniprotkb:P20426|uniprotkb:Q14013|uniprotkb:Q5U065|uniprotkb:D3DVV8|uniprotkb:B4DYS6 psi-mi:taf1d_human(display_long)|uniprotkb:RNA polymerase I-specific TBP-associated factor 41 kDa(gene name synonym)|uniprotkb:TAF1D(gene name)|psi-mi:TAF1D(display_short)|uniprotkb:JOSD3(gene name synonym)|uniprotkb:TATA box-binding protein-associated factor 1D(gene name synonym)|uniprotkb:Transcription initiation factor SL1/TIF-IB subunit D(gene name synonym) psi-mi:csk21_human(display_long)|uniprotkb:CSNK2A1(gene name)|psi-mi:CSNK2A1(display_short)|uniprotkb:CK2A1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510669|imex:IM-12079-6 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_077021.1|ensembl:ENSG00000166012(gene)|ensembl:ENST00000323981(transcript)|ensembl:ENST00000448108(transcript)|ensembl:ENST00000526015(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005668"(RNA polymerase transcription factor SL1 complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0034451"(centriolar satellite)|go:"GO:0042802"(identical protein binding)|go:"GO:0072686"(mitotic spindle)|interpro:IPR027976|reactome:R-HSA-427359|reactome:R-HSA-427413|reactome:R-HSA-5250924|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73863 rcsb pdb:6TLS|rcsb pdb:6TLU|rcsb pdb:6TLV|rcsb pdb:6TLW|rcsb pdb:6YPG|rcsb pdb:6YPH|rcsb pdb:6YPJ|rcsb pdb:6YPK|rcsb pdb:6YPN|rcsb pdb:6YUL|rcsb pdb:6YUM|rcsb pdb:6YZH|rcsb pdb:6Z19|rcsb pdb:6Z83|rcsb pdb:6Z84|rcsb pdb:7A49|rcsb pdb:6TLR|rcsb pdb:7A4B|rcsb pdb:7A4C|rcsb pdb:7B8H|rcsb pdb:3PE2|rcsb pdb:3PE4|rcsb pdb:3Q04|rcsb pdb:3Q9W|rcsb pdb:3Q9X|rcsb pdb:3Q9Y|rcsb pdb:3Q9Z|rcsb pdb:3QA0|rcsb pdb:3R0T|rcsb pdb:3RPS|rcsb pdb:3TAX|rcsb pdb:3U4U|rcsb pdb:3U87|rcsb pdb:3U9C|rcsb pdb:3W8L|rcsb pdb:3WAR|rcsb pdb:3WIK|rcsb pdb:3WIL|rcsb pdb:3WOW|rcsb pdb:3PE1|rcsb pdb:4DGL|rcsb pdb:4FBX|ensembl:ENSG00000101266(gene)|ensembl:ENST00000217244(transcript)|ensembl:ENST00000400217(transcript)|ensembl:ENST00000643660(transcript)|ensembl:ENST00000645623(transcript)|ensembl:ENST00000646305(transcript)|ensembl:ENST00000646561(transcript)|ensembl:ENST00000646814(transcript)|ensembl:ENST00000647348(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005956"(protein kinase CK2 complex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016301"(kinase activity)|go:"GO:0016580"(Sin3 complex)|go:"GO:0016581"(NuRD complex)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|rcsb pdb:4GUB|rcsb pdb:4GYW|rcsb pdb:4GYY|rcsb pdb:4GZ3|rcsb pdb:4IB5|rcsb pdb:4KWP|rcsb pdb:4MD7|rcsb pdb:4MD8|rcsb pdb:4MD9|rcsb pdb:4NH1|rcsb pdb:4RLL|rcsb pdb:4UB7|rcsb pdb:4GRB|rcsb pdb:4UBA|rcsb pdb:5B0X|rcsb pdb:5CLP|rcsb pdb:5CQU|rcsb pdb:5CQW|rcsb pdb:5CS6|rcsb pdb:5CSH|rcsb pdb:5CSP|rcsb pdb:5CSV|rcsb pdb:7BU4|rcsb pdb:7B8I|reactome:R-HSA-1483191|reactome:R-HSA-201688|reactome:R-HSA-2514853|reactome:R-HSA-445144|reactome:R-HSA-6804756|reactome:R-HSA-6814122|reactome:R-HSA-8932339|reactome:R-HSA-8934903|reactome:R-HSA-8939243|reactome:R-HSA-8948751|rcsb pdb:5CTP|rcsb pdb:5CU0|rcsb pdb:5CU2|rcsb pdb:5CU3|rcsb pdb:5CU4|rcsb pdb:5CU6|rcsb pdb:5CVF|rcsb pdb:5CVG|rcsb pdb:5CVH|rcsb pdb:5CX9|rcsb pdb:5H8B|rcsb pdb:5H8E|rcsb pdb:5H8G|rcsb pdb:5HGV|rcsb pdb:5KU8|rcsb pdb:5KWH|rcsb pdb:5M44|rcsb pdb:5M4C|rcsb pdb:5M4F|rcsb pdb:5M4I|rcsb pdb:5MMF|rcsb pdb:5MMR|rcsb pdb:5MO5|rcsb pdb:5MO6|rcsb pdb:5MO7|rcsb pdb:5MO8|rcsb pdb:5MOD|rcsb pdb:5MOE|rcsb pdb:5MOH|rcsb pdb:5MOT|rcsb pdb:5MOV|rcsb pdb:5MOW|rcsb pdb:5MP8|rcsb pdb:5MPJ|rcsb pdb:5N1V|rcsb pdb:5N9K|rcsb pdb:5N9L|rcsb pdb:5N9N|rcsb pdb:5NQC|rcsb pdb:5OMY|rcsb pdb:5ONI|rcsb pdb:5OQU|rcsb pdb:5ORH|rcsb pdb:5ORJ|rcsb pdb:5ORK|rcsb pdb:5CT0|rcsb pdb:5OT6|rcsb pdb:5OTD|rcsb pdb:5OTH|rcsb pdb:5OTI|rcsb pdb:5OTL|rcsb pdb:5OTO|rcsb pdb:5OTP|rcsb pdb:5OTQ|rcsb pdb:5OTR|rcsb pdb:5OTS|rcsb pdb:5OTY|rcsb pdb:5OTZ|rcsb pdb:5OUE|rcsb pdb:5OS7|rcsb pdb:5OUL|rcsb pdb:5OUM|rcsb pdb:5OS8|rcsb pdb:5OUU|rcsb pdb:5OWH|rcsb pdb:5OSL|rcsb pdb:5OWL|rcsb pdb:5OSP|rcsb pdb:5OYF|rcsb pdb:5T1H|rcsb pdb:5VIE|rcsb pdb:5VIF|rcsb pdb:5ZN0|rcsb pdb:5ZN1|rcsb pdb:5OSR|rcsb pdb:5OSU|rcsb pdb:5OSZ|rcsb pdb:5ZN2|rcsb pdb:5OT5|rcsb pdb:5ZN3|rcsb pdb:5ZN4|rcsb pdb:5ZN5|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048511"(rhythmic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1905818"(regulation of chromosome separation)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P68400|rcsb pdb:1JWH|rcsb pdb:1NA7|rcsb pdb:1PJK|rcsb pdb:2PVR|rcsb pdb:2ZJW|rcsb pdb:3AMY|rcsb pdb:3AT2|rcsb pdb:3AT3|rcsb pdb:3AT4|rcsb pdb:3AXW|rcsb pdb:3BQC|rcsb pdb:3C13|rcsb pdb:3FWQ|rcsb pdb:3H30|rcsb pdb:3JUH|rcsb pdb:3MB6|rcsb pdb:3MB7|rcsb pdb:3NGA|rcsb pdb:3NSZ|interpro:IPR011009(Protein kinase-like)|rcsb pdb:3OWJ|rcsb pdb:3OWK|rcsb pdb:3OWL|rcsb pdb:6E37|rcsb pdb:6EHK|rcsb pdb:6EHU|rcsb pdb:6EII|rcsb pdb:6FVF|rcsb pdb:6FVG|rcsb pdb:6GIH|rcsb pdb:6GMD|rcsb pdb:6HBN|rcsb pdb:6HME|rcsb pdb:6HNW|rcsb pdb:6HNY|rcsb pdb:6HOP|rcsb pdb:6HOQ|rcsb pdb:6HOR|rcsb pdb:6HOT|rcsb pdb:6HOU|rcsb pdb:6JWA|rcsb pdb:6L1Z|rcsb pdb:6L21|rcsb pdb:6L22|rcsb pdb:6L23|rcsb pdb:6L24|rcsb pdb:6Q38|rcsb pdb:6Q4Q|rcsb pdb:6QY7|rcsb pdb:6RB1|rcsb pdb:6RCB|rcsb pdb:6RCM|rcsb pdb:6RFE|rcsb pdb:6RFF|rcsb pdb:6SPW|rcsb pdb:6A1C|rcsb pdb:6SPX|rcsb pdb:6TEI|rcsb pdb:6TLL|rcsb pdb:6TLO|rcsb pdb:6TLP|refseq:NP_001886.1|refseq:NP_808227.1|refseq:NP_808228.1|dip:DIP-32682N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/01/23 rogid:n8Hb6nlOaMdKQ4nHySrsHDWYiIE9606 rogid:5PLQNJJpbPzJhA0sqogKhl9umIQ9606 intact-crc:0B3374381A3BC871|rigid:Fq9Ht+CDowoae44lyk+ICXX4bWM false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H5J8 uniprotkb:Q9GZS1 intact:EBI-716128|uniprotkb:Q6I9Y6|ensembl:ENSP00000314971|ensembl:ENSP00000410409|ensembl:ENSP00000435087 intact:EBI-359458|uniprotkb:Q5VZT3|uniprotkb:Q8NBA9|uniprotkb:Q96L20|ensembl:ENSP00000367029|intact:EBI-21026140 psi-mi:taf1d_human(display_long)|uniprotkb:RNA polymerase I-specific TBP-associated factor 41 kDa(gene name synonym)|uniprotkb:TAF1D(gene name)|psi-mi:TAF1D(display_short)|uniprotkb:JOSD3(gene name synonym)|uniprotkb:TATA box-binding protein-associated factor 1D(gene name synonym)|uniprotkb:Transcription initiation factor SL1/TIF-IB subunit D(gene name synonym) psi-mi:rpa49_human(display_long)|uniprotkb:POLR1E(gene name)|psi-mi:POLR1E(display_short)|uniprotkb:PAF53(gene name synonym)|uniprotkb:PRAF1(gene name synonym)|uniprotkb:DNA-directed RNA polymerase I subunit E(gene name synonym)|uniprotkb:RNA polymerase I-associated factor 1(gene name synonym)|uniprotkb:RNA polymerase I-associated factor 53(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510669|imex:IM-12079-6 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_077021.1|ensembl:ENSG00000166012(gene)|ensembl:ENST00000323981(transcript)|ensembl:ENST00000448108(transcript)|ensembl:ENST00000526015(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005668"(RNA polymerase transcription factor SL1 complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0034451"(centriolar satellite)|go:"GO:0042802"(identical protein binding)|go:"GO:0072686"(mitotic spindle)|interpro:IPR027976|reactome:R-HSA-427359|reactome:R-HSA-427413|reactome:R-HSA-5250924|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73863 refseq:NP_001269695.1|refseq:NP_071935.1|ensembl:ENSG00000137054(gene)|ensembl:ENST00000377798(transcript)|go:"GO:0001179"(RNA polymerase I general transcription initiation factor binding)|go:"GO:0001188"(RNA polymerase I preinitiation complex assembly)|go:"GO:0001650"(fibrillar center)|go:"GO:0003677"(DNA binding)|go:"GO:0003899"(DNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005736"(RNA polymerase I complex)|go:"GO:0006362"(transcription elongation from RNA polymerase I promoter)|go:"GO:0042790"(nucleolar large rRNA transcription by RNA polymerase I)|interpro:IPR009668(RNA polymerase I associated factor, A49-like)|mint:Q9GZS1|reactome:R-HSA-5250924|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73863|reactome:R-HSA-427413|refseq:XP_005251604.1|dip:DIP-27546N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/01/23 rogid:n8Hb6nlOaMdKQ4nHySrsHDWYiIE9606 rogid:3cidLGlybOTCIJGQ6xweDrvBBYM9606 intact-crc:0B3374381A3BC871|rigid:Fq9Ht+CDowoae44lyk+ICXX4bWM false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q6GQQ9 uniprotkb:Q9H845 intact:EBI-527784|uniprotkb:Q8WWA7|uniprotkb:Q9NQ53|uniprotkb:Q9UFF4|uniprotkb:Q5SZ60|ensembl:ENSP00000462729|uniprotkb:D3DUZ8|uniprotkb:B7Z643 intact:EBI-2510719|ensembl:ENSP00000312618|ensembl:ENSP00000506340|uniprotkb:Q8WXX3|uniprotkb:D3DNB8 psi-mi:otu7b_human(display_long)|uniprotkb:Zinc finger protein Cezanne(gene name synonym)|uniprotkb:Zinc finger A20 domain-containing protein 1(gene name synonym)|uniprotkb:Cellular zinc finger anti-NF-kappa-B protein(gene name synonym)|uniprotkb:OTUD7B(gene name)|psi-mi:OTUD7B(display_short)|uniprotkb:ZA20D1(gene name synonym) psi-mi:acad9_human(display_long)|uniprotkb:ACAD9(gene name)|psi-mi:ACAD9(display_short)|uniprotkb:Acyl-CoA dehydrogenase family member 9(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510717|imex:IM-12079-57 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-33805N|ensembl:ENSG00000264522(gene)|ensembl:ENST00000581312(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002385"(mucosal immune response)|go:"GO:0003677"(DNA binding)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008234"(cysteine-type peptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0035871"(protein K11-linked deubiquitination)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:0071947"(protein deubiquitination involved in ubiquitin-dependent protein catabolic process)|go:"GO:1900181"(negative regulation of protein localization to nucleus)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR002653(Zinc finger, A20-type)|interpro:IPR003323(Ovarian tumour, otubain)|rcsb pdb:5LRU|rcsb pdb:5LRV|rcsb pdb:5LRW|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5689896|ensembl:ENSP00000462729|refseq:NP_064590.2 ensembl:ENSG00000177646(gene)|ensembl:ENST00000308982(transcript)|ensembl:ENST00000681583(transcript)|go:"GO:0000062"(fatty-acyl-CoA binding)|go:"GO:0001676"(long-chain fatty acid metabolic process)|go:"GO:0004466"(long-chain-acyl-CoA dehydrogenase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0017099"(very-long-chain-acyl-CoA dehydrogenase activity)|go:"GO:0030425"(dendrite)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0051791"(medium-chain fatty acid metabolic process)|go:"GO:0070991"(medium-chain-acyl-CoA dehydrogenase activity)|interpro:IPR006089(Acyl-CoA dehydrogenase, conserved site)|interpro:IPR006091(Acyl-CoA dehydrogenase/oxidase, central region)|interpro:IPR009075(Acyl-CoA dehydrogenase/oxidase C-terminal)|interpro:IPR009100(Acyl-CoA dehydrogenase/oxidase, middle and N-terminal)|interpro:IPR013786(Acyl-CoA dehydrogenase/oxidase, N-terminal)|interpro:IPR036250|interpro:IPR037069|reactome:R-HSA-6799198|go:"GO:0050660"(flavin adenine dinucleotide binding)|refseq:NP_054768.2|dip:DIP-53699N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:JZKj6CpuUOQ3aqvmg3YC9OnivGM9606 rogid:1ev99zlKVgMW3KWlcSdzmTtMTvA9606 intact-crc:7B41B56EDF0F3C80|rigid:0mJN5AJz1uNxFD6NxjEuRtXmh+w false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q6GQQ9 uniprotkb:Q15599 intact:EBI-527784|uniprotkb:Q8WWA7|uniprotkb:Q9NQ53|uniprotkb:Q9UFF4|uniprotkb:Q5SZ60|ensembl:ENSP00000462729|uniprotkb:D3DUZ8|uniprotkb:B7Z643 intact:EBI-1149760|uniprotkb:O00272|uniprotkb:O00556|uniprotkb:Q3KQY7|uniprotkb:D3DU84|uniprotkb:D3DU85|uniprotkb:H3BSV6|ensembl:ENSP00000408005|intact:EBI-15579694 psi-mi:otu7b_human(display_long)|uniprotkb:Zinc finger protein Cezanne(gene name synonym)|uniprotkb:Zinc finger A20 domain-containing protein 1(gene name synonym)|uniprotkb:Cellular zinc finger anti-NF-kappa-B protein(gene name synonym)|uniprotkb:OTUD7B(gene name)|psi-mi:OTUD7B(display_short)|uniprotkb:ZA20D1(gene name synonym) psi-mi:nhrf2_human(display_long)|uniprotkb:SLC9A3R2(gene name)|psi-mi:SLC9A3R2(display_short)|uniprotkb:NHERF2(gene name synonym)|uniprotkb:Tyrosine kinase activator protein 1(gene name synonym)|uniprotkb:SRY-interacting protein 1(gene name synonym)|uniprotkb:Solute carrier family 9 isoform A3 regulatory factor 2(gene name synonym)|uniprotkb:NHE3 kinase A regulatory protein E3KARP(gene name synonym)|uniprotkb:Sodium-hydrogen exchanger regulatory factor 2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510717|imex:IM-12079-57 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-33805N|ensembl:ENSG00000264522(gene)|ensembl:ENST00000581312(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002385"(mucosal immune response)|go:"GO:0003677"(DNA binding)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008234"(cysteine-type peptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0035871"(protein K11-linked deubiquitination)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:0071947"(protein deubiquitination involved in ubiquitin-dependent protein catabolic process)|go:"GO:1900181"(negative regulation of protein localization to nucleus)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR002653(Zinc finger, A20-type)|interpro:IPR003323(Ovarian tumour, otubain)|rcsb pdb:5LRU|rcsb pdb:5LRV|rcsb pdb:5LRW|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5689896|ensembl:ENSP00000462729|refseq:NP_064590.2 refseq:NP_001123484.1|refseq:NP_004776.3|refseq:NP_001239002.1|ensembl:ENSG00000065054(gene)|ensembl:ENST00000424542(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0012505"(endomembrane system)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019902"(phosphatase binding)|go:"GO:0031799"(type 2 metabotropic glutamate receptor binding)|go:"GO:0031800"(type 3 metabotropic glutamate receptor binding)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0045296"(cadherin binding)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR015098(EBP50, C-terminal)|interpro:IPR017300("Na(+)/H(+) exchange regulatory cofactor NHE-RF")|interpro:IPR031197|interpro:IPR036034|mint:Q15599|rcsb pdb:2D11|rcsb pdb:2HE4|rcsb pdb:2OCS|rcsb pdb:4P0C|go:"GO:0042802"(identical protein binding)|dip:DIP-29093N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:JZKj6CpuUOQ3aqvmg3YC9OnivGM9606 rogid:BRqFx6BigKEZV84KUdfvppEXg+s9606 intact-crc:7B41B56EDF0F3C80|rigid:0mJN5AJz1uNxFD6NxjEuRtXmh+w false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q6GQQ9 uniprotkb:Q9NWT6 intact:EBI-527784|uniprotkb:Q8WWA7|uniprotkb:Q9NQ53|uniprotkb:Q9UFF4|uniprotkb:Q5SZ60|ensembl:ENSP00000462729|uniprotkb:D3DUZ8|uniprotkb:B7Z643 intact:EBI-745632|uniprotkb:Q969Q7|uniprotkb:Q9NPV5|uniprotkb:Q5W147|ensembl:ENSP00000299163|uniprotkb:D3DR69 psi-mi:otu7b_human(display_long)|uniprotkb:Zinc finger protein Cezanne(gene name synonym)|uniprotkb:Zinc finger A20 domain-containing protein 1(gene name synonym)|uniprotkb:Cellular zinc finger anti-NF-kappa-B protein(gene name synonym)|uniprotkb:OTUD7B(gene name)|psi-mi:OTUD7B(display_short)|uniprotkb:ZA20D1(gene name synonym) psi-mi:hif1n_human(display_long)|uniprotkb:Hypoxia-inducible factor asparagine hydroxylase(gene name synonym)|uniprotkb:Factor inhibiting HIF-1(gene name synonym)|uniprotkb:HIF1AN(gene name)|psi-mi:HIF1AN(display_short)|uniprotkb:FIH1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510717|imex:IM-12079-57 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-33805N|ensembl:ENSG00000264522(gene)|ensembl:ENST00000581312(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002385"(mucosal immune response)|go:"GO:0003677"(DNA binding)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008234"(cysteine-type peptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0035871"(protein K11-linked deubiquitination)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:0071947"(protein deubiquitination involved in ubiquitin-dependent protein catabolic process)|go:"GO:1900181"(negative regulation of protein localization to nucleus)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR002653(Zinc finger, A20-type)|interpro:IPR003323(Ovarian tumour, otubain)|rcsb pdb:5LRU|rcsb pdb:5LRV|rcsb pdb:5LRW|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5689896|ensembl:ENSP00000462729|refseq:NP_064590.2 refseq:NP_060372.2|ensembl:ENSG00000166135(gene)|ensembl:ENST00000299163(transcript)|go:"GO:0005112"(Notch binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016706"(2-oxoglutarate-dependent dioxygenase activity)|go:"GO:0019826"(oxygen sensor activity)|go:"GO:0031406"(carboxylic acid binding)|go:"GO:0036138"(peptidyl-histidine hydroxylation)|go:"GO:0036139"(peptidyl-histidine dioxygenase activity)|go:"GO:0036140"(peptidyl-asparagine 3-dioxygenase activity)|go:"GO:0042264"(peptidyl-aspartic acid hydroxylation)|go:"GO:0042265"(peptidyl-asparagine hydroxylation)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0061428"(negative regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0071532"(ankyrin repeat binding)|go:"GO:0102113"(hypoxia-inducible factor-asparagine oxygenase activity)|go:"GO:2001214"(positive regulation of vasculogenesis)|interpro:IPR003347(Transcription factor jumonji/aspartyl beta-hydroxylase)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR027445|interpro:IPR027452|interpro:IPR041667|mint:Q9NWT6|rcsb pdb:1H2K|rcsb pdb:1H2L|rcsb pdb:1H2M|rcsb pdb:1H2N|rcsb pdb:1IZ3|rcsb pdb:1MZE|rcsb pdb:1MZF|rcsb pdb:1YCI|rcsb pdb:2CGN|rcsb pdb:2CGO|rcsb pdb:2ILM|rcsb pdb:2W0X|rcsb pdb:2WA3|rcsb pdb:2WA4|rcsb pdb:2XUM|rcsb pdb:2Y0I|rcsb pdb:2YC0|rcsb pdb:2YDE|rcsb pdb:3D8C|rcsb pdb:3KCX|rcsb pdb:3KCY|rcsb pdb:3OD4|rcsb pdb:3P3N|rcsb pdb:3P3P|rcsb pdb:4AI8|rcsb pdb:4B7E|rcsb pdb:4B7K|rcsb pdb:4BIO|rcsb pdb:4JAA|rcsb pdb:4NR1|rcsb pdb:4Z1V|rcsb pdb:4Z2W|rcsb pdb:5JWK|rcsb pdb:5JWL|rcsb pdb:5JWP|rcsb pdb:5OP6|rcsb pdb:6H9J|rcsb pdb:6HA6|rcsb pdb:6HC8|rcsb pdb:6HKP|rcsb pdb:6HL5|rcsb pdb:6HL6|rcsb pdb:6RUJ|reactome:R-HSA-1234174|rcsb pdb:5OP8|rcsb pdb:5OPC|dip:DIP-35527N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:JZKj6CpuUOQ3aqvmg3YC9OnivGM9606 rogid:lvPtfqlB1+hOcdCAwcopj/Yl+3Y9606 intact-crc:7B41B56EDF0F3C80|rigid:0mJN5AJz1uNxFD6NxjEuRtXmh+w false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q6GQQ9 uniprotkb:O75694 intact:EBI-527784|uniprotkb:Q8WWA7|uniprotkb:Q9NQ53|uniprotkb:Q9UFF4|uniprotkb:Q5SZ60|ensembl:ENSP00000462729|uniprotkb:D3DUZ8|uniprotkb:B7Z643 intact:EBI-1050769|uniprotkb:Q9UBE9|uniprotkb:Q9UFL5|intact:EBI-28983292|ensembl:ENSP00000231498 psi-mi:otu7b_human(display_long)|uniprotkb:Zinc finger protein Cezanne(gene name synonym)|uniprotkb:Zinc finger A20 domain-containing protein 1(gene name synonym)|uniprotkb:Cellular zinc finger anti-NF-kappa-B protein(gene name synonym)|uniprotkb:OTUD7B(gene name)|psi-mi:OTUD7B(display_short)|uniprotkb:ZA20D1(gene name synonym) psi-mi:nu155_human(display_long)|uniprotkb:Nucleoporin Nup155(gene name synonym)|uniprotkb:155 kDa nucleoporin(gene name synonym)|uniprotkb:KIAA0791(gene name synonym)|uniprotkb:NUP155(gene name)|psi-mi:NUP155(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510717|imex:IM-12079-57 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) dip:DIP-33805N|ensembl:ENSG00000264522(gene)|ensembl:ENST00000581312(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002385"(mucosal immune response)|go:"GO:0003677"(DNA binding)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008234"(cysteine-type peptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0035871"(protein K11-linked deubiquitination)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:0071947"(protein deubiquitination involved in ubiquitin-dependent protein catabolic process)|go:"GO:1900181"(negative regulation of protein localization to nucleus)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR002653(Zinc finger, A20-type)|interpro:IPR003323(Ovarian tumour, otubain)|rcsb pdb:5LRU|rcsb pdb:5LRV|rcsb pdb:5LRW|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5689896|ensembl:ENSP00000462729|refseq:NP_064590.2 refseq:NP_004289.1|refseq:NP_705618.1|ensembl:ENSP00000231498|ensembl:ENST00000381843|ensembl:ENSP00000371265|ensembl:ENSG00000113569(gene)|ensembl:ENST00000231498(transcript)|go:"GO:0000972"(transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005829"(cytosol)|go:"GO:0006405"(RNA export from nucleus)|go:"GO:0006406"(mRNA export from nucleus)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006998"(nuclear envelope organization)|go:"GO:0016020"(membrane)|go:"GO:0017056"(structural constituent of nuclear pore)|go:"GO:0031965"(nuclear membrane)|go:"GO:0036228"(protein localization to nuclear inner membrane)|go:"GO:0044611"(nuclear pore inner ring)|go:"GO:0086014"(atrial cardiac muscle cell action potential)|interpro:IPR004870(Nucleoporin, non-repetitive/WGA-negative)|interpro:IPR007187(Nucleoporin, Nup133-like, C-terminal)|interpro:IPR014908(Nup133, N-terminal)|interpro:IPR042533|interpro:IPR042537|interpro:IPR042538|rcsb pdb:5A9Q|rcsb pdb:5IJN|rcsb pdb:5IJO|reactome:R-HSA-1169408|reactome:R-HSA-159227|reactome:R-HSA-159230|reactome:R-HSA-159231|reactome:R-HSA-159236|reactome:R-HSA-165054|reactome:R-HSA-168271|reactome:R-HSA-168276|reactome:R-HSA-168325|reactome:R-HSA-168333|reactome:R-HSA-170822|reactome:R-HSA-180746|reactome:R-HSA-180910|reactome:R-HSA-191859|reactome:R-HSA-3108214|reactome:R-HSA-3232142|reactome:R-HSA-3301854|reactome:R-HSA-3371453|reactome:R-HSA-4085377|reactome:R-HSA-4551638|reactome:R-HSA-4570464|reactome:R-HSA-4615885|reactome:R-HSA-5578749|reactome:R-HSA-5619107|reactome:R-HSA-6784531|reactome:R-HSA-9609690|reactome:R-HSA-9610379|reactome:R-HSA-9615933 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:JZKj6CpuUOQ3aqvmg3YC9OnivGM9606 rogid:k6LjWvJdqtT78G4Wu12rJX/2WHo9606 intact-crc:7B41B56EDF0F3C80|rigid:0mJN5AJz1uNxFD6NxjEuRtXmh+w false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P78347 uniprotkb:Q96DC9 intact:EBI-359622|uniprotkb:Q75M88|uniprotkb:O14743|uniprotkb:O15359|uniprotkb:O43546|uniprotkb:O43588|uniprotkb:O43589|uniprotkb:Q9BSZ4|uniprotkb:Q86U51|uniprotkb:Q75M85|uniprotkb:Q75M86|uniprotkb:Q75M87|ensembl:ENSP00000460070 intact:EBI-746259|uniprotkb:Q9H6T1|uniprotkb:Q6IA10|ensembl:ENSP00000203664|ensembl:ENSP00000478628 psi-mi:gtf2i_human(display_long)|uniprotkb:GTF2I(gene name)|psi-mi:GTF2I(display_short)|uniprotkb:BAP135(gene name synonym)|uniprotkb:WBSCR6(gene name synonym)|uniprotkb:Bruton tyrosine kinase-associated protein 135(gene name synonym)|uniprotkb:SRF-Phox1-interacting protein(gene name synonym)|uniprotkb:Williams-Beuren syndrome chromosomal region 6 protein(gene name synonym) psi-mi:otub2_human(display_long)|uniprotkb:Otubain-2(gene name synonym)|uniprotkb:OTU domain-containing ubiquitin aldehyde-binding protein 2(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease OTUB2(gene name synonym)|uniprotkb:Deubiquitinating enzyme OTUB2(gene name synonym)|uniprotkb:OTUB2(gene name)|psi-mi:OTUB2(display_short)|uniprotkb:C14orf137(gene name synonym)|uniprotkb:OTB2(gene name synonym)|uniprotkb:OTU2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510766|imex:IM-12079-58 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001509.3|refseq:NP_127492.1|refseq:NP_127493.1|refseq:NP_127494.1|ensembl:ENSG00000263001(gene)|ensembl:ENST00000573035(transcript)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0016020"(membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0100026"(positive regulation of DNA repair by transcription from RNA polymerase II promoter)|interpro:IPR004212(GTF2I-like repeat)|interpro:IPR016659(Transcription factor II-I)|mint:P78347|rcsb pdb:2D9B|rcsb pdb:2DN4|rcsb pdb:2ED2|rcsb pdb:2EJE|interpro:IPR036647|refseq:NP_001157108.1|refseq:NP_001267729.1|dip:DIP-24252N refseq:NP_075601.1|go:"GO:1901315"(negative regulation of histone H2A K63-linked ubiquitination)|go:"GO:2000780"(negative regulation of double-strand break repair)|interpro:IPR003323(Ovarian tumour, otubain)|interpro:IPR016615(Ubiquitin thioesterase Otubain)|interpro:IPR019400|interpro:IPR030299|interpro:IPR038765|interpro:IPR042467|interpro:IPR042468|rcsb pdb:1TFF|rcsb pdb:4FJV|rcsb pdb:5QIO|rcsb pdb:5QIP|rcsb pdb:5QIQ|rcsb pdb:5QIR|rcsb pdb:5QIS|rcsb pdb:5QIT|rcsb pdb:5QIU|rcsb pdb:5QIV|rcsb pdb:5QIW|rcsb pdb:5QIX|rcsb pdb:5QIY|rcsb pdb:5QIZ|reactome:R-HSA-5689896|ensembl:ENSG00000089723(gene)|ensembl:ENSG00000277276(gene)|ensembl:ENST00000203664(transcript)|ensembl:ENST00000617748(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035871"(protein K11-linked deubiquitination)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination) psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:DqfrIS0Ey+XvZfTXmk9KQzBtQo49606 rogid:VRoMLaGboqq1kdgtxKBy76srvi09606 intact-crc:8CDCAA627131C822|rigid:p6NbeBhQs7hdUfcTx6g6l6i6l4w false - ha tag:n-n|flag tag:n-n - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96FW1 uniprotkb:O95630 intact:EBI-1058491|uniprotkb:Q32Q78|uniprotkb:Q96II3|uniprotkb:Q9NXQ4|uniprotkb:Q9P0B8|ensembl:ENSP00000402551|ensembl:ENSP00000444357 intact:EBI-396676|uniprotkb:Q3MJE7|uniprotkb:D6W5H7|uniprotkb:B5M0B6|ensembl:ENSP00000344742|ensembl:ENSP00000377633|ensembl:ENSP00000377636|ensembl:ENSP00000386548|ensembl:ENSP00000506833|ensembl:ENSP00000506845|ensembl:ENSP00000506865|ensembl:ENSP00000506958|ensembl:ENSP00000507014|ensembl:ENSP00000507054|ensembl:ENSP00000507081|ensembl:ENSP00000507092|ensembl:ENSP00000507639|ensembl:ENSP00000507658|ensembl:ENSP00000507864 psi-mi:otub1_human(display_long)|uniprotkb:OTUB1(gene name)|psi-mi:OTUB1(display_short)|uniprotkb:OTB1(gene name synonym)|uniprotkb:OTU1(gene name synonym)|uniprotkb:Otubain-1(gene name synonym)|uniprotkb:OTU domain-containing ubiquitin aldehyde-binding protein 1(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease OTUB1(gene name synonym)|uniprotkb:Deubiquitinating enzyme OTUB1(gene name synonym)|uniprotkb:HSPC263(orf name) psi-mi:stabp_human(display_long)|uniprotkb:AMSH(gene name synonym)|uniprotkb:STAMBP(gene name)|psi-mi:STAMBP(display_short)|uniprotkb:Associated molecule with the SH3 domain of STAM(gene name synonym)|uniprotkb:Endosome-associated ubiquitin isopeptidase(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510744|imex:IM-12079-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_060140.2|ensembl:ENSG00000167770(gene)|ensembl:ENST00000428192(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0019784"(NEDD8-specific protease activity)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0043130"(ubiquitin binding)|ensembl:ENST00000538426(transcript)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:1901315"(negative regulation of histone H2A K63-linked ubiquitination)|go:"GO:2000780"(negative regulation of double-strand break repair)|interpro:IPR003323(Ovarian tumour, otubain)|interpro:IPR016615(Ubiquitin thioesterase Otubain)|interpro:IPR019400|interpro:IPR030298|interpro:IPR038765|interpro:IPR042467|interpro:IPR042468|mint:Q96FW1|rcsb pdb:2ZFY|rcsb pdb:3VON|rcsb pdb:4DDG|rcsb pdb:4DDI|rcsb pdb:4DHZ|rcsb pdb:4I6L|rcsb pdb:4LDT|reactome:R-HSA-5689880|reactome:R-HSA-5689896|dip:DIP-41158N refseq:NP_006454.1|refseq:NP_964010.1|refseq:NP_998787.1|refseq:XP_005264145.1|refseq:XP_011530785.1|refseq:XP_016858664.1|go:"GO:0016020"(membrane)|go:"GO:0014067"(negative regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032154"(cleavage furrow)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0046872"(metal ion binding)|go:"GO:0061578"(Lys63-specific deubiquitinase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070122"(isopeptidase activity)|go:"GO:0070536"(protein K63-linked deubiquitination)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR015063(Region of unknown function DUF1873)|interpro:IPR037518|interpro:IPR044098|mint:O95630|rcsb pdb:2XZE|rcsb pdb:3RZU|rcsb pdb:3RZV|rcsb pdb:5IXF|reactome:R-HSA-5689901|ensembl:ENSG00000124356(gene)|ensembl:ENST00000339566(transcript)|ensembl:ENST00000394070(transcript)|ensembl:ENST00000394073(transcript)|ensembl:ENST00000409707(transcript)|ensembl:ENST00000682351(transcript)|ensembl:ENST00000682379(transcript)|ensembl:ENST00000682558(transcript)|ensembl:ENST00000682847(transcript)|ensembl:ENST00000683036(transcript)|ensembl:ENST00000683317(transcript)|ensembl:ENST00000683518(transcript)|ensembl:ENST00000683818(transcript)|ensembl:ENST00000684095(transcript)|ensembl:ENST00000684312(transcript)|ensembl:ENST00000684585(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|dip:DIP-33062N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2017/12/08 rogid:jD7ZA6L1tq8K8LO70w2RnGhZv349606 rogid:JUvszgPz9rog/OEpmABJ295BaLw9606 intact-crc:C115CAAD2876A9E4|rigid:thuoGfgxTZ834HSq/G712eay4F8 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96FW1 uniprotkb:P61088 intact:EBI-1058491|uniprotkb:Q32Q78|uniprotkb:Q96II3|uniprotkb:Q9NXQ4|uniprotkb:Q9P0B8|ensembl:ENSP00000402551|ensembl:ENSP00000444357 intact:EBI-1052908|uniprotkb:Q16781|uniprotkb:Q53Y81|ensembl:ENSP00000316176 psi-mi:otub1_human(display_long)|uniprotkb:OTUB1(gene name)|psi-mi:OTUB1(display_short)|uniprotkb:OTB1(gene name synonym)|uniprotkb:OTU1(gene name synonym)|uniprotkb:Otubain-1(gene name synonym)|uniprotkb:OTU domain-containing ubiquitin aldehyde-binding protein 1(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease OTUB1(gene name synonym)|uniprotkb:Deubiquitinating enzyme OTUB1(gene name synonym)|uniprotkb:HSPC263(orf name) psi-mi:ube2n_human(display_long)|uniprotkb:Ubiquitin-protein ligase N(gene name synonym)|uniprotkb:Ubiquitin carrier protein N(gene name synonym)|uniprotkb:Ubc13(gene name synonym)|uniprotkb:Bendless-like ubiquitin-conjugating enzyme(gene name synonym)|uniprotkb:UBE2N(gene name)|psi-mi:UBE2N(display_short)|uniprotkb:BLU(gene name synonym)|uniprotkb:UbcH13(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme N(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510744|imex:IM-12079-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_060140.2|ensembl:ENSG00000167770(gene)|ensembl:ENST00000428192(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0019784"(NEDD8-specific protease activity)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0043130"(ubiquitin binding)|ensembl:ENST00000538426(transcript)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:1901315"(negative regulation of histone H2A K63-linked ubiquitination)|go:"GO:2000780"(negative regulation of double-strand break repair)|interpro:IPR003323(Ovarian tumour, otubain)|interpro:IPR016615(Ubiquitin thioesterase Otubain)|interpro:IPR019400|interpro:IPR030298|interpro:IPR038765|interpro:IPR042467|interpro:IPR042468|mint:Q96FW1|rcsb pdb:2ZFY|rcsb pdb:3VON|rcsb pdb:4DDG|rcsb pdb:4DDI|rcsb pdb:4DHZ|rcsb pdb:4I6L|rcsb pdb:4LDT|reactome:R-HSA-5689880|reactome:R-HSA-5689896|dip:DIP-41158N refseq:NP_003339.1|dip:DIP-29829N|ensembl:ENSG00000177889(gene)|ensembl:ENST00000318066(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0031058"(positive regulation of histone modification)|go:"GO:0031372"(UBC13-MMS2 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033182"(regulation of histone ubiquitination)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:1J7D|rcsb pdb:2C2V|rcsb pdb:3HCT|rcsb pdb:3HCU|rcsb pdb:3VON|rcsb pdb:3W31|rcsb pdb:4DHI|rcsb pdb:4DHJ|rcsb pdb:4DHZ|rcsb pdb:4IP3|rcsb pdb:4NR3|rcsb pdb:4NRG|rcsb pdb:4NRI|rcsb pdb:4ONL|rcsb pdb:4ONM|rcsb pdb:4ONN|rcsb pdb:4ORH|rcsb pdb:4TKP|rcsb pdb:4WHV|rcsb pdb:5AIT|rcsb pdb:5AIU|rcsb pdb:5EYA|rcsb pdb:5H7S|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5YWR|rcsb pdb:6D6I|rcsb pdb:6JKY|rcsb pdb:6KFP|rcsb pdb:6KG6|rcsb pdb:6KL4|rcsb pdb:6LP2|rcsb pdb:6P5B|rcsb pdb:6S53|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-5696395|reactome:R-HSA-69473|reactome:R-HSA-8866654|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|rcsb pdb:6ULH|rcsb pdb:6UMP|rcsb pdb:6UMS|rcsb pdb:7BBD|rcsb pdb:7BBF|rcsb pdb:7BXG|reactome:R-HSA-1169408|reactome:R-HSA-168638 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2017/12/08 rogid:jD7ZA6L1tq8K8LO70w2RnGhZv349606 rogid:dqdszHlq5FLPHC6UWX6uvkC6Yz89606 intact-crc:C115CAAD2876A9E4|rigid:thuoGfgxTZ834HSq/G712eay4F8 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96FW1 uniprotkb:Q9UBL6 intact:EBI-1058491|uniprotkb:Q32Q78|uniprotkb:Q96II3|uniprotkb:Q9NXQ4|uniprotkb:Q9P0B8|ensembl:ENSP00000402551|ensembl:ENSP00000444357 intact:EBI-744841|ensembl:ENSP00000268720 psi-mi:otub1_human(display_long)|uniprotkb:OTUB1(gene name)|psi-mi:OTUB1(display_short)|uniprotkb:OTB1(gene name synonym)|uniprotkb:OTU1(gene name synonym)|uniprotkb:Otubain-1(gene name synonym)|uniprotkb:OTU domain-containing ubiquitin aldehyde-binding protein 1(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease OTUB1(gene name synonym)|uniprotkb:Deubiquitinating enzyme OTUB1(gene name synonym)|uniprotkb:HSPC263(orf name) psi-mi:cpne7_human(display_long)|uniprotkb:Copine VII(gene name synonym)|uniprotkb:CPNE7(gene name)|psi-mi:CPNE7(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510744|imex:IM-12079-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_060140.2|ensembl:ENSG00000167770(gene)|ensembl:ENST00000428192(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0019784"(NEDD8-specific protease activity)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0043130"(ubiquitin binding)|ensembl:ENST00000538426(transcript)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:1901315"(negative regulation of histone H2A K63-linked ubiquitination)|go:"GO:2000780"(negative regulation of double-strand break repair)|interpro:IPR003323(Ovarian tumour, otubain)|interpro:IPR016615(Ubiquitin thioesterase Otubain)|interpro:IPR019400|interpro:IPR030298|interpro:IPR038765|interpro:IPR042467|interpro:IPR042468|mint:Q96FW1|rcsb pdb:2ZFY|rcsb pdb:3VON|rcsb pdb:4DDG|rcsb pdb:4DDI|rcsb pdb:4DHZ|rcsb pdb:4I6L|rcsb pdb:4LDT|reactome:R-HSA-5689880|reactome:R-HSA-5689896|dip:DIP-41158N refseq:NP_055242.1|refseq:NP_705900.1|ensembl:ENSG00000178773(gene)|ensembl:ENST00000268720(transcript)|go:"GO:0005215"(transporter activity)|go:"GO:0005544"(calcium-dependent phospholipid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071277"(cellular response to calcium ion)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR010734(Copine)|interpro:IPR035892|interpro:IPR036465|interpro:IPR037768|reactome:R-HSA-1483206 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2017/12/08 rogid:jD7ZA6L1tq8K8LO70w2RnGhZv349606 rogid:zbz44x4Pq11/acUxb3kN/8xrVRk9606 intact-crc:C115CAAD2876A9E4|rigid:thuoGfgxTZ834HSq/G712eay4F8 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96FW1 uniprotkb:P43246 intact:EBI-1058491|uniprotkb:Q32Q78|uniprotkb:Q96II3|uniprotkb:Q9NXQ4|uniprotkb:Q9P0B8|ensembl:ENSP00000402551|ensembl:ENSP00000444357 intact:EBI-355888|uniprotkb:O75488|uniprotkb:B4E2Z2|ensembl:ENSP00000233146 psi-mi:otub1_human(display_long)|uniprotkb:OTUB1(gene name)|psi-mi:OTUB1(display_short)|uniprotkb:OTB1(gene name synonym)|uniprotkb:OTU1(gene name synonym)|uniprotkb:Otubain-1(gene name synonym)|uniprotkb:OTU domain-containing ubiquitin aldehyde-binding protein 1(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease OTUB1(gene name synonym)|uniprotkb:Deubiquitinating enzyme OTUB1(gene name synonym)|uniprotkb:HSPC263(orf name) psi-mi:msh2_human(display_long)|uniprotkb:MSH2(gene name)|psi-mi:MSH2(display_short)|uniprotkb:MutS protein homolog 2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510744|imex:IM-12079-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_060140.2|ensembl:ENSG00000167770(gene)|ensembl:ENST00000428192(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0019784"(NEDD8-specific protease activity)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0043130"(ubiquitin binding)|ensembl:ENST00000538426(transcript)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:1901315"(negative regulation of histone H2A K63-linked ubiquitination)|go:"GO:2000780"(negative regulation of double-strand break repair)|interpro:IPR003323(Ovarian tumour, otubain)|interpro:IPR016615(Ubiquitin thioesterase Otubain)|interpro:IPR019400|interpro:IPR030298|interpro:IPR038765|interpro:IPR042467|interpro:IPR042468|mint:Q96FW1|rcsb pdb:2ZFY|rcsb pdb:3VON|rcsb pdb:4DDG|rcsb pdb:4DDI|rcsb pdb:4DHZ|rcsb pdb:4I6L|rcsb pdb:4LDT|reactome:R-HSA-5689880|reactome:R-HSA-5689896|dip:DIP-41158N refseq:NP_000242.1|refseq:NP_001245210.1|ensembl:ENSG00000095002(gene)|ensembl:ENST00000233146(transcript)|go:"GO:0000406"(double-strand/single-strand DNA junction binding)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0002204"(somatic recombination of immunoglobulin genes involved in immune response)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006119"(oxidative phosphorylation)|go:"GO:0006281"(DNA repair)|go:"GO:0006298"(mismatch repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0007281"(germ cell development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008584"(male gonad development)|go:"GO:0010165"(response to X-ray)|go:"GO:0010224"(response to UV-B)|go:"GO:0016020"(membrane)|go:"GO:0016446"(somatic hypermutation of immunoglobulin genes)|go:"GO:0016447"(somatic recombination of immunoglobulin gene segments)|go:"GO:0019237"(centromeric DNA binding)|go:"GO:0019724"(B cell mediated immunity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0032137"(guanine/thymine mispair binding)|go:"GO:0032300"(mismatch repair complex)|go:"GO:0032301"(MutSalpha complex)|go:"GO:0032302"(MutSbeta complex)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043570"(maintenance of DNA repeat elements)|go:"GO:0045190"(isotype switching)|go:"GO:0045910"(negative regulation of DNA recombination)|go:"GO:0048298"(positive regulation of isotype switching to IgA isotypes)|go:"GO:0048304"(positive regulation of isotype switching to IgG isotypes)|go:"GO:0051096"(positive regulation of helicase activity)|go:"GO:0071168"(protein localization to chromatin)|interpro:IPR000432(DNA mismatch repair protein MutS, C-terminal)|interpro:IPR007695(DNA mismatch repair protein MutS-like, N-terminal)|interpro:IPR007696(DNA mismatch repair protein MutS, core)|interpro:IPR007860(DNA mismatch repair protein MutS, connector)|interpro:IPR007861(DNA mismatch repair protein MutS, clamp)|interpro:IPR011184(DNA mismatch repair protein, MSH2)|interpro:IPR016151(DNA mismatch repair protein MutS, N-terminal)|interpro:IPR027417|interpro:IPR032642|interpro:IPR036187|interpro:IPR036678|mint:P43246|rcsb pdb:2O8B|rcsb pdb:2O8C|rcsb pdb:2O8D|rcsb pdb:2O8E|rcsb pdb:2O8F|rcsb pdb:3THW|rcsb pdb:3THX|rcsb pdb:3THY|rcsb pdb:3THZ|reactome:R-HSA-5358565|reactome:R-HSA-5358606|reactome:R-HSA-5632927|reactome:R-HSA-5632928|reactome:R-HSA-5632968|reactome:R-HSA-6796648|dip:DIP-35054N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2017/12/08 rogid:jD7ZA6L1tq8K8LO70w2RnGhZv349606 rogid:7vcyX6SkXRo28b+4b+JBg7j/ec89606 intact-crc:C115CAAD2876A9E4|rigid:thuoGfgxTZ834HSq/G712eay4F8 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96FW1 uniprotkb:P31944 intact:EBI-1058491|uniprotkb:Q32Q78|uniprotkb:Q96II3|uniprotkb:Q9NXQ4|uniprotkb:Q9P0B8|ensembl:ENSP00000402551|ensembl:ENSP00000444357 intact:EBI-2510738|ensembl:ENSP00000393417|uniprotkb:O95823|uniprotkb:Q3SYC9 psi-mi:otub1_human(display_long)|uniprotkb:OTUB1(gene name)|psi-mi:OTUB1(display_short)|uniprotkb:OTB1(gene name synonym)|uniprotkb:OTU1(gene name synonym)|uniprotkb:Otubain-1(gene name synonym)|uniprotkb:OTU domain-containing ubiquitin aldehyde-binding protein 1(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease OTUB1(gene name synonym)|uniprotkb:Deubiquitinating enzyme OTUB1(gene name synonym)|uniprotkb:HSPC263(orf name) psi-mi:caspe_human(display_long)|uniprotkb:CASP14(gene name)|psi-mi:CASP14(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510744|imex:IM-12079-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_060140.2|ensembl:ENSG00000167770(gene)|ensembl:ENST00000428192(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0019784"(NEDD8-specific protease activity)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0043130"(ubiquitin binding)|ensembl:ENST00000538426(transcript)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:1901315"(negative regulation of histone H2A K63-linked ubiquitination)|go:"GO:2000780"(negative regulation of double-strand break repair)|interpro:IPR003323(Ovarian tumour, otubain)|interpro:IPR016615(Ubiquitin thioesterase Otubain)|interpro:IPR019400|interpro:IPR030298|interpro:IPR038765|interpro:IPR042467|interpro:IPR042468|mint:Q96FW1|rcsb pdb:2ZFY|rcsb pdb:3VON|rcsb pdb:4DDG|rcsb pdb:4DDI|rcsb pdb:4DHZ|rcsb pdb:4I6L|rcsb pdb:4LDT|reactome:R-HSA-5689880|reactome:R-HSA-5689896|dip:DIP-41158N interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR029030|interpro:IPR033139|interpro:IPR033174|mint:P31944|reactome:R-HSA-6809371|ensembl:ENSG00000105141(gene)|ensembl:ENST00000427043(transcript)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0008544"(epidermis development)|go:"GO:0031424"(keratinization)|go:"GO:0045095"(keratin filament)|go:"GO:0070268"(cornification)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|refseq:NP_036246.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2017/12/08 rogid:jD7ZA6L1tq8K8LO70w2RnGhZv349606 rogid:e8QPsuebgXeKJEuMm/KU0WAOs3k9606 intact-crc:C115CAAD2876A9E4|rigid:thuoGfgxTZ834HSq/G712eay4F8 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96FW1 uniprotkb:P62837 intact:EBI-1058491|uniprotkb:Q32Q78|uniprotkb:Q96II3|uniprotkb:Q9NXQ4|uniprotkb:Q9P0B8|ensembl:ENSP00000402551|ensembl:ENSP00000444357 intact:EBI-347677|uniprotkb:P51669|uniprotkb:Q3MN78|uniprotkb:D3DQC9|uniprotkb:Q96RP6|ensembl:ENSP00000381717|ensembl:ENSP00000381718 psi-mi:otub1_human(display_long)|uniprotkb:OTUB1(gene name)|psi-mi:OTUB1(display_short)|uniprotkb:OTB1(gene name synonym)|uniprotkb:OTU1(gene name synonym)|uniprotkb:Otubain-1(gene name synonym)|uniprotkb:OTU domain-containing ubiquitin aldehyde-binding protein 1(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease OTUB1(gene name synonym)|uniprotkb:Deubiquitinating enzyme OTUB1(gene name synonym)|uniprotkb:HSPC263(orf name) psi-mi:ub2d2_human(display_long)|uniprotkb:UBC5B(gene name synonym)|uniprotkb:UBCH4(gene name synonym)|uniprotkb:UBE2D2(gene name)|psi-mi:UBE2D2(display_short)|uniprotkb:UBC4(gene name synonym)|uniprotkb:UBCH5B(gene name synonym)|uniprotkb:Ubiquitin-protein ligase D2(gene name synonym)|uniprotkb:Ubiquitin carrier protein D2(gene name synonym)|uniprotkb:Ubiquitin-conjugating enzyme E2-17 kDa 2(gene name synonym)|uniprotkb:"Ubiquitin-conjugating enzyme E2(17)KB 2"(gene name synonym)|uniprotkb:PUBC1(gene name synonym)|uniprotkb:p53-regulated ubiquitin-conjugating enzyme 1(gene name synonym)|uniprotkb:"(E3-independent) E2 ubiquitin-conjugating enzyme D2"(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme D2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510744|imex:IM-12079-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_060140.2|ensembl:ENSG00000167770(gene)|ensembl:ENST00000428192(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0019784"(NEDD8-specific protease activity)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0043130"(ubiquitin binding)|ensembl:ENST00000538426(transcript)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:1901315"(negative regulation of histone H2A K63-linked ubiquitination)|go:"GO:2000780"(negative regulation of double-strand break repair)|interpro:IPR003323(Ovarian tumour, otubain)|interpro:IPR016615(Ubiquitin thioesterase Otubain)|interpro:IPR019400|interpro:IPR030298|interpro:IPR038765|interpro:IPR042467|interpro:IPR042468|mint:Q96FW1|rcsb pdb:2ZFY|rcsb pdb:3VON|rcsb pdb:4DDG|rcsb pdb:4DDI|rcsb pdb:4DHZ|rcsb pdb:4I6L|rcsb pdb:4LDT|reactome:R-HSA-5689880|reactome:R-HSA-5689896|dip:DIP-41158N refseq:NP_003330.1|refseq:NP_862821.1|dip:DIP-29267N|ensembl:ENSG00000131508(gene)|ensembl:ENST00000398733(transcript)|ensembl:ENST00000398734(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032991"(protein-containing complex)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070936"(protein K48-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|mint:P62837|rcsb pdb:1UR6|rcsb pdb:1W4U|rcsb pdb:2CLW|rcsb pdb:2ESK|rcsb pdb:2ESO|rcsb pdb:2ESP|rcsb pdb:2ESQ|rcsb pdb:3A33|rcsb pdb:3JVZ|rcsb pdb:3JW0|rcsb pdb:3L1Y|rcsb pdb:3TGD|rcsb pdb:3ZNI|rcsb pdb:4A49|rcsb pdb:4A4B|rcsb pdb:4A4C|rcsb pdb:4AUQ|rcsb pdb:4DDG|rcsb pdb:4DDI|rcsb pdb:4LDT|rcsb pdb:4V3K|rcsb pdb:4V3L|rcsb pdb:4WZ3|rcsb pdb:5D0K|rcsb pdb:5D0M|rcsb pdb:5D1K|rcsb pdb:5D1L|rcsb pdb:5D1M|rcsb pdb:5EDV|rcsb pdb:5MNJ|rcsb pdb:5ULF|rcsb pdb:5ULH|rcsb pdb:5ULK|rcsb pdb:5VZW|rcsb pdb:5ZBU|rcsb pdb:6HPR|rcsb pdb:6M2C|rcsb pdb:6SQO|rcsb pdb:6SQR|rcsb pdb:6SQS|rcsb pdb:6TTU|rcsb pdb:6W7Z|rcsb pdb:6W9D|rcsb pdb:7AI0|rcsb pdb:7AI1|rcsb pdb:7BOL|reactome:R-HSA-1234176|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-5607764|reactome:R-HSA-8866652|reactome:R-HSA-8866654|reactome:R-HSA-8951664|reactome:R-HSA-9033241|reactome:R-HSA-936440|reactome:R-HSA-937041|reactome:R-HSA-9705462|reactome:R-HSA-983168 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2017/12/08 rogid:jD7ZA6L1tq8K8LO70w2RnGhZv349606 rogid:vVGrEi0osU/WG0Y9qRCFMT4lgvg9606 intact-crc:C115CAAD2876A9E4|rigid:thuoGfgxTZ834HSq/G712eay4F8 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96FW1 uniprotkb:Q96FW1 intact:EBI-1058491|uniprotkb:Q32Q78|uniprotkb:Q96II3|uniprotkb:Q9NXQ4|uniprotkb:Q9P0B8|ensembl:ENSP00000402551|ensembl:ENSP00000444357 intact:EBI-1058491|uniprotkb:Q32Q78|uniprotkb:Q96II3|uniprotkb:Q9NXQ4|uniprotkb:Q9P0B8|ensembl:ENSP00000402551|ensembl:ENSP00000444357 psi-mi:otub1_human(display_long)|uniprotkb:OTUB1(gene name)|psi-mi:OTUB1(display_short)|uniprotkb:OTB1(gene name synonym)|uniprotkb:OTU1(gene name synonym)|uniprotkb:Otubain-1(gene name synonym)|uniprotkb:OTU domain-containing ubiquitin aldehyde-binding protein 1(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease OTUB1(gene name synonym)|uniprotkb:Deubiquitinating enzyme OTUB1(gene name synonym)|uniprotkb:HSPC263(orf name) psi-mi:otub1_human(display_long)|uniprotkb:OTUB1(gene name)|psi-mi:OTUB1(display_short)|uniprotkb:OTB1(gene name synonym)|uniprotkb:OTU1(gene name synonym)|uniprotkb:Otubain-1(gene name synonym)|uniprotkb:OTU domain-containing ubiquitin aldehyde-binding protein 1(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease OTUB1(gene name synonym)|uniprotkb:Deubiquitinating enzyme OTUB1(gene name synonym)|uniprotkb:HSPC263(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510744|imex:IM-12079-7 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_060140.2|ensembl:ENSG00000167770(gene)|ensembl:ENST00000428192(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0019784"(NEDD8-specific protease activity)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0043130"(ubiquitin binding)|ensembl:ENST00000538426(transcript)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:1901315"(negative regulation of histone H2A K63-linked ubiquitination)|go:"GO:2000780"(negative regulation of double-strand break repair)|interpro:IPR003323(Ovarian tumour, otubain)|interpro:IPR016615(Ubiquitin thioesterase Otubain)|interpro:IPR019400|interpro:IPR030298|interpro:IPR038765|interpro:IPR042467|interpro:IPR042468|mint:Q96FW1|rcsb pdb:2ZFY|rcsb pdb:3VON|rcsb pdb:4DDG|rcsb pdb:4DDI|rcsb pdb:4DHZ|rcsb pdb:4I6L|rcsb pdb:4LDT|reactome:R-HSA-5689880|reactome:R-HSA-5689896|dip:DIP-41158N refseq:NP_060140.2|ensembl:ENSG00000167770(gene)|ensembl:ENST00000428192(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0019784"(NEDD8-specific protease activity)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0043130"(ubiquitin binding)|ensembl:ENST00000538426(transcript)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:1901315"(negative regulation of histone H2A K63-linked ubiquitination)|go:"GO:2000780"(negative regulation of double-strand break repair)|interpro:IPR003323(Ovarian tumour, otubain)|interpro:IPR016615(Ubiquitin thioesterase Otubain)|interpro:IPR019400|interpro:IPR030298|interpro:IPR038765|interpro:IPR042467|interpro:IPR042468|mint:Q96FW1|rcsb pdb:2ZFY|rcsb pdb:3VON|rcsb pdb:4DDG|rcsb pdb:4DDI|rcsb pdb:4DHZ|rcsb pdb:4I6L|rcsb pdb:4LDT|reactome:R-HSA-5689880|reactome:R-HSA-5689896|dip:DIP-41158N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2017/12/08 rogid:jD7ZA6L1tq8K8LO70w2RnGhZv349606 rogid:jD7ZA6L1tq8K8LO70w2RnGhZv349606 intact-crc:C115CAAD2876A9E4|rigid:thuoGfgxTZ834HSq/G712eay4F8 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q5VV17 uniprotkb:O75369 intact:EBI-2510778|ensembl:ENSP00000365678 intact:EBI-352089|intact:EBI-1754974|uniprotkb:Q13706|uniprotkb:Q59EC2|uniprotkb:Q6MZJ1|uniprotkb:Q8WXS9|uniprotkb:Q8WXT0|uniprotkb:Q8WXT1|uniprotkb:Q8WXT2|uniprotkb:Q9NRB5|uniprotkb:B2ZZ84|uniprotkb:Q9NT26|uniprotkb:Q9UEV9|intact:EBI-1960054|uniprotkb:C9JKE6|uniprotkb:B2ZZ85|uniprotkb:C9JMC4|ensembl:ENSP00000295956|uniprotkb:B2ZZ83|uniprotkb:Q60FE7|uniprotkb:Q8WXT3 psi-mi:otud1_human(display_long)|uniprotkb:OTUD1(gene name)|psi-mi:OTUD1(display_short)|uniprotkb:DUBA7(gene name synonym)|uniprotkb:OTDC1(gene name synonym)|uniprotkb:DUBA-7(gene name synonym) psi-mi:flnb_human(display_long)|uniprotkb:FLNB(gene name)|psi-mi:FLNB(display_short)|uniprotkb:FLN1L(gene name synonym)|uniprotkb:FLN3(gene name synonym)|uniprotkb:TABP(gene name synonym)|uniprotkb:TAP(gene name synonym)|uniprotkb:Beta-filamin(gene name synonym)|uniprotkb:Actin-binding-like protein(gene name synonym)|uniprotkb:Thyroid autoantigen(gene name synonym)|uniprotkb:Truncated actin-binding protein(gene name synonym)|uniprotkb:ABP-280 homolog(gene name synonym)|uniprotkb:ABP-278(gene name synonym)|uniprotkb:Filamin-3(gene name synonym)|uniprotkb:Filamin homolog 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510776|imex:IM-12079-8 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000165312(gene)|ensembl:ENST00000376495(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0070536"(protein K63-linked deubiquitination)|interpro:IPR003323(Ovarian tumour, otubain)|interpro:IPR038765|rcsb pdb:4BOP|refseq:NP_001138845.1 refseq:NP_001157791.1|refseq:NP_001448.2|go:"GO:0003334"(keratinocyte development)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0003723"(RNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0007165"(signal transduction)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030018"(Z disc)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045296"(cadherin binding)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0051015"(actin filament binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071346"(cellular response to interferon-gamma)|interpro:IPR001298(Filamin/ABP280 repeat)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017868|interpro:IPR029874|interpro:IPR036872|interpro:IPR044801|mint:O75369|rcsb pdb:2DI8|rcsb pdb:2DI9|rcsb pdb:2DIA|rcsb pdb:2DIB|rcsb pdb:2DIC|rcsb pdb:2DJ4|rcsb pdb:2DLG|rcsb pdb:2DMB|rcsb pdb:2DMC|rcsb pdb:2E9I|rcsb pdb:2E9J|rcsb pdb:2EE6|rcsb pdb:2EE9|rcsb pdb:2EEA|rcsb pdb:2EEB|rcsb pdb:2EEC|rcsb pdb:2EED|rcsb pdb:2WA5|rcsb pdb:2WA6|rcsb pdb:2WA7|rcsb pdb:3FER|rcsb pdb:4B7L|rcsb pdb:5DCP|reactome:R-HSA-1169408|ensembl:ENSG00000136068(gene)|ensembl:ENST00000295956(transcript)|go:"GO:0001725"(stress fiber)|refseq:NP_001157789.1|refseq:NP_001157790.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:BISOnPKUXNIZ+cNVrtvnKJpw3sA9606 rogid:lsf6C/Vg0io7UhUi1Kapgwp0p5E9606 intact-crc:97C23036CCD4CECF|rigid:JRX3iWAmaJpSs6a6TMbSqpQg3Eo false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q5VV17 uniprotkb:Q14315 intact:EBI-2510778|ensembl:ENSP00000365678 intact:EBI-489954|uniprotkb:O95303|uniprotkb:Q07985|uniprotkb:Q9NS12|uniprotkb:Q9NYE5|uniprotkb:Q9UMR8|uniprotkb:Q9Y503|uniprotkb:B2ZZ88|ensembl:ENSP00000327145 psi-mi:otud1_human(display_long)|uniprotkb:OTUD1(gene name)|psi-mi:OTUD1(display_short)|uniprotkb:DUBA7(gene name synonym)|uniprotkb:OTDC1(gene name synonym)|uniprotkb:DUBA-7(gene name synonym) psi-mi:flnc_human(display_long)|uniprotkb:Filamin-2(gene name synonym)|uniprotkb:Actin-binding-like protein(gene name synonym)|uniprotkb:ABP-L(gene name synonym)|uniprotkb:ABP-280-like protein(gene name synonym)|uniprotkb:Gamma-filamin(gene name synonym)|uniprotkb:FLNC(gene name)|psi-mi:FLNC(display_short)|uniprotkb:ABPL(gene name synonym)|uniprotkb:FLN2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510776|imex:IM-12079-8 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000165312(gene)|ensembl:ENST00000376495(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0070536"(protein K63-linked deubiquitination)|interpro:IPR003323(Ovarian tumour, otubain)|interpro:IPR038765|rcsb pdb:4BOP|refseq:NP_001138845.1 refseq:NP_001120959.1|refseq:NP_001449.3|ensembl:ENSG00000128591(gene)|ensembl:ENST00000325888(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0016528"(sarcoplasm)|go:"GO:0030018"(Z disc)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030506"(ankyrin binding)|go:"GO:0042383"(sarcolemma)|go:"GO:0042802"(identical protein binding)|go:"GO:0043034"(costamere)|go:"GO:0051015"(actin filament binding)|go:"GO:0055001"(muscle cell development)|interpro:IPR001298(Filamin/ABP280 repeat)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017868|interpro:IPR036872|interpro:IPR044801|mint:Q14315|rcsb pdb:1V05|rcsb pdb:2D7M|rcsb pdb:2D7N|rcsb pdb:2D7O|rcsb pdb:2D7P|rcsb pdb:2D7Q|rcsb pdb:2K9U|rcsb pdb:2NQC|rcsb pdb:3V8O|rcsb pdb:4MGX|reactome:R-HSA-446353|dip:DIP-33398N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:BISOnPKUXNIZ+cNVrtvnKJpw3sA9606 rogid:sBGhjObBECicoAu/8T5lDIt1ToY9606 intact-crc:97C23036CCD4CECF|rigid:JRX3iWAmaJpSs6a6TMbSqpQg3Eo false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q5VV17 uniprotkb:P54725 intact:EBI-2510778|ensembl:ENSP00000365678 intact:EBI-746453|uniprotkb:Q59EU8|uniprotkb:Q5M7Z1|uniprotkb:K7ESE3|ensembl:ENSP00000467024 psi-mi:otud1_human(display_long)|uniprotkb:OTUD1(gene name)|psi-mi:OTUD1(display_short)|uniprotkb:DUBA7(gene name synonym)|uniprotkb:OTDC1(gene name synonym)|uniprotkb:DUBA-7(gene name synonym) psi-mi:rd23a_human(display_long)|uniprotkb:RAD23A(gene name)|psi-mi:RAD23A(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510776|imex:IM-12079-8 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000165312(gene)|ensembl:ENST00000376495(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0070536"(protein K63-linked deubiquitination)|interpro:IPR003323(Ovarian tumour, otubain)|interpro:IPR038765|rcsb pdb:4BOP|refseq:NP_001138845.1 refseq:NP_005044.1|refseq:NP_001257291.1|refseq:NP_001257292.1|dip:DIP-34442N|ensembl:ENSG00000179262(gene)|ensembl:ENST00000586534(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0019900"(kinase binding)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0032434"(regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034451"(centriolar satellite)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0070628"(proteasome binding)|go:"GO:1990381"(ubiquitin-specific protease binding)|interpro:IPR000626(Ubiquitin)|interpro:IPR004806(UV excision repair protein Rad23)|interpro:IPR006636(Heat shock chaperonin-binding)|interpro:IPR009060(UBA-like)|interpro:IPR015360(XPC-binding domain)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR029071|interpro:IPR036353|interpro:IPR041811|mint:P54725|rcsb pdb:1DV0|rcsb pdb:1F4I|rcsb pdb:1IFY|rcsb pdb:1OQY|rcsb pdb:1P98|rcsb pdb:1P9D|rcsb pdb:1QZE|rcsb pdb:1TP4|rcsb pdb:1ZO6|rcsb pdb:2WYQ|rcsb pdb:5XBO|rcsb pdb:6W2G|rcsb pdb:6W2H|rcsb pdb:6W2I|reactome:R-HSA-5689877|reactome:R-HSA-5696394|reactome:R-HSA-5696395 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:BISOnPKUXNIZ+cNVrtvnKJpw3sA9606 rogid:l/29QSvlTrWQMG3wLyeb/QxeaiU9606 intact-crc:97C23036CCD4CECF|rigid:JRX3iWAmaJpSs6a6TMbSqpQg3Eo false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q5VV17 uniprotkb:P54727 intact:EBI-2510778|ensembl:ENSP00000365678 intact:EBI-954531|uniprotkb:Q8WUB0|uniprotkb:B3KWK8|ensembl:ENSP00000350708|uniprotkb:G5E9P0|uniprotkb:Q7Z5K8 psi-mi:otud1_human(display_long)|uniprotkb:OTUD1(gene name)|psi-mi:OTUD1(display_short)|uniprotkb:DUBA7(gene name synonym)|uniprotkb:OTDC1(gene name synonym)|uniprotkb:DUBA-7(gene name synonym) psi-mi:rd23b_human(display_long)|uniprotkb:XP-C repair-complementing complex 58 kDa protein(gene name synonym)|uniprotkb:RAD23B(gene name)|psi-mi:RAD23B(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510776|imex:IM-12079-8 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000165312(gene)|ensembl:ENST00000376495(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0070536"(protein K63-linked deubiquitination)|interpro:IPR003323(Ovarian tumour, otubain)|interpro:IPR038765|rcsb pdb:4BOP|refseq:NP_001138845.1 refseq:NP_002865.1|refseq:NP_001231653.1|ensembl:ENSG00000119318(gene)|ensembl:ENST00000358015(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0000715"(nucleotide-excision repair, DNA damage recognition)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0007283"(spermatogenesis)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0032434"(regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0048568"(embryonic organ development)|go:"GO:0070628"(proteasome binding)|go:"GO:0071942"(XPC complex)|go:"GO:0098761"(cellular response to interleukin-7)|interpro:IPR000626(Ubiquitin)|interpro:IPR004806(UV excision repair protein Rad23)|interpro:IPR006636(Heat shock chaperonin-binding)|interpro:IPR009060(UBA-like)|interpro:IPR015360(XPC-binding domain)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR036353|interpro:IPR041811|mint:P54727|rcsb pdb:1P1A|rcsb pdb:1PVE|rcsb pdb:1UEL|reactome:R-HSA-532668|reactome:R-HSA-5689877|reactome:R-HSA-5696394|reactome:R-HSA-5696395|interpro:IPR029071|dip:DIP-39944N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:BISOnPKUXNIZ+cNVrtvnKJpw3sA9606 rogid:msyh4+G2TzDW+xgGjixPKWWrjRE9606 intact-crc:97C23036CCD4CECF|rigid:JRX3iWAmaJpSs6a6TMbSqpQg3Eo false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q5VV17 uniprotkb:A4D1J9 intact:EBI-2510778|ensembl:ENSP00000365678 intact:EBI-2510782 psi-mi:otud1_human(display_long)|uniprotkb:OTUD1(gene name)|psi-mi:OTUD1(display_short)|uniprotkb:DUBA7(gene name synonym)|uniprotkb:OTDC1(gene name synonym)|uniprotkb:DUBA-7(gene name synonym) psi-mi:a4d1j9_human(display_long)|uniprotkb:LOC392787(gene name)|psi-mi:LOC392787(display_short)|uniprotkb:tcag7.1102(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510776|imex:IM-12079-8 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000165312(gene)|ensembl:ENST00000376495(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0070536"(protein K63-linked deubiquitination)|interpro:IPR003323(Ovarian tumour, otubain)|interpro:IPR038765|rcsb pdb:4BOP|refseq:NP_001138845.1 go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030154"(cell differentiation)|go:"GO:0051015"(actin filament binding)|interpro:IPR001298(Filamin/ABP280 repeat)|interpro:IPR017868|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR029874|interpro:IPR044801 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:BISOnPKUXNIZ+cNVrtvnKJpw3sA9606 rogid:DKS1WiVISy+o0rz2hUQqYB6IB+Y9606 intact-crc:97C23036CCD4CECF|rigid:JRX3iWAmaJpSs6a6TMbSqpQg3Eo false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q5VV17 uniprotkb:P21333 intact:EBI-2510778|ensembl:ENSP00000365678 intact:EBI-350432|uniprotkb:Q8NF52|intact:EBI-1103234|ensembl:ENSP00000358866|uniprotkb:Q5HY53|uniprotkb:Q5HY55|uniprotkb:E9KL45 psi-mi:otud1_human(display_long)|uniprotkb:OTUD1(gene name)|psi-mi:OTUD1(display_short)|uniprotkb:DUBA7(gene name synonym)|uniprotkb:OTDC1(gene name synonym)|uniprotkb:DUBA-7(gene name synonym) psi-mi:flna_human(display_long)|uniprotkb:FLNA(gene name)|psi-mi:FLNA(display_short)|uniprotkb:FLN(gene name synonym)|uniprotkb:FLN1(gene name synonym)|uniprotkb:Alpha-filamin(gene name synonym)|uniprotkb:Filamin-1(gene name synonym)|uniprotkb:Endothelial actin-binding protein(gene name synonym)|uniprotkb:Actin-binding protein 280(gene name synonym)|uniprotkb:Non-muscle filamin(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510776|imex:IM-12079-8 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000165312(gene)|ensembl:ENST00000376495(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0070536"(protein K63-linked deubiquitination)|interpro:IPR003323(Ovarian tumour, otubain)|interpro:IPR038765|rcsb pdb:4BOP|refseq:NP_001138845.1 go:"GO:0007195"(adenylate cyclase-inhibiting dopamine receptor signaling pathway)|go:"GO:1902396"(protein localization to bicellular tight junction)|refseq:NP_001104026.1|refseq:NP_001447.2|ensembl:ENSG00000196924(gene)|ensembl:ENST00000369850(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003723"(RNA binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048680"(positive regulation of axon regeneration)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051015"(actin filament binding)|go:"GO:0051020"(GTPase binding)|go:"GO:0051220"(cytoplasmic sequestering of protein)|go:"GO:0051764"(actin crosslink formation)|go:"GO:0060271"(cilium assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:0071526"(semaphorin-plexin signaling pathway)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090042"(tubulin deacetylation)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:0097368"(establishment of Sertoli cell barrier)|go:"GO:0097440"(apical dendrite)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1901381"(positive regulation of potassium ion transmembrane transport)|go:"GO:0046332"(SMAD binding)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016479"(negative regulation of transcription by RNA polymerase I)|go:"GO:0019900"(kinase binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0021943"(formation of radial glial scaffolds)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030018"(Z disc)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031523"(Myb complex)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031852"(mu-type opioid receptor binding)|go:"GO:0032233"(positive regulation of actin filament bundle assembly)|go:"GO:0032432"(actin filament bundle)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0034988"(Fc-gamma receptor I complex binding)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043113"(receptor clustering)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044319"(wound healing, spreading of cells)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0045296"(cadherin binding)|reactome:R-HSA-114608|reactome:R-HSA-430116|reactome:R-HSA-446353|reactome:R-HSA-5627123|reactome:R-HSA-8983711|rcsb pdb:6EW1|go:"GO:1905031"(regulation of membrane repolarization during cardiac muscle cell action potential)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2001046"(positive regulation of integrin-mediated signaling pathway)|go:"GO:2001224"(positive regulation of neuron migration)|interpro:IPR001298(Filamin/ABP280 repeat)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017868|interpro:IPR036872|interpro:IPR044801|mint:P21333|rcsb pdb:2AAV|rcsb pdb:2BP3|rcsb pdb:2BRQ|rcsb pdb:2J3S|rcsb pdb:2JF1|rcsb pdb:2K3T|rcsb pdb:2K7P|rcsb pdb:2K7Q|rcsb pdb:2MTP|rcsb pdb:2W0P|rcsb pdb:2WFN|rcsb pdb:3CNK|rcsb pdb:3HOC|rcsb pdb:3HOP|rcsb pdb:3HOR|rcsb pdb:3ISW|rcsb pdb:3RGH|rcsb pdb:4M9P|rcsb pdb:4P3W|rcsb pdb:5XR1|rcsb pdb:6D8C|go:"GO:1905000"(regulation of membrane repolarization during atrial cardiac muscle cell action potential)|dip:DIP-1136N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:BISOnPKUXNIZ+cNVrtvnKJpw3sA9606 rogid:ZxGK5OSMy8cNsyt7Ax2KXb8bn9M9606 intact-crc:97C23036CCD4CECF|rigid:JRX3iWAmaJpSs6a6TMbSqpQg3Eo false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q5VVQ6 uniprotkb:Q96J01 intact:EBI-2510804|ensembl:ENSP00000326813|uniprotkb:Q86T63|uniprotkb:B2RNX3|uniprotkb:Q5VVQ5|uniprotkb:Q9P1L8|uniprotkb:Q6ZRS6 intact:EBI-2510823|ensembl:ENSP00000265097|uniprotkb:Q6NZ53 psi-mi:otu1_human(display_long)|uniprotkb:YOD1(gene name)|psi-mi:YOD1(display_short)|uniprotkb:DUBA8(gene name synonym)|uniprotkb:HIN7(gene name synonym)|uniprotkb:OTUD2(gene name synonym)|uniprotkb:OTU domain-containing protein 2(gene name synonym)|uniprotkb:DUBA-8(gene name synonym)|uniprotkb:HIV-1-induced protease 7(gene name synonym)|uniprotkb:PRO0907(orf name) psi-mi:thoc3_human(display_long)|uniprotkb:THOC3(gene name)|psi-mi:THOC3(display_short)|uniprotkb:TEX1 homolog(gene name synonym)|uniprotkb:hTREX45(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510813|imex:IM-12079-59 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:4BOZ|reactome:R-HSA-5689896|rcsb pdb:4BOS|ensembl:ENSG00000180667(gene)|ensembl:ENST00000315927(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016236"(macroautophagy)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035523"(protein K29-linked deubiquitination)|go:"GO:0035871"(protein K11-linked deubiquitination)|go:"GO:0046872"(metal ion binding)|go:"GO:0061578"(Lys63-specific deubiquitinase activity)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:0101005"(deubiquitinase activity)|go:"GO:1904153"(negative regulation of retrograde protein transport, ER to cytosol)|go:"GO:1990167"(protein K27-linked deubiquitination)|go:"GO:1990168"(protein K33-linked deubiquitination)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR003323(Ovarian tumour, otubain)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR029071|interpro:IPR038765|interpro:IPR039138|rcsb pdb:4BOQ|refseq:NP_001263249.1|refseq:NP_061036.3 ensembl:ENSG00000051596(gene)|ensembl:ENST00000265097(transcript)|go:"GO:0000346"(transcription export complex)|go:"GO:0000445"(THO complex part of transcription export complex)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006397"(mRNA processing)|go:"GO:0006406"(mRNA export from nucleus)|go:"GO:0008380"(RNA splicing)|go:"GO:0016607"(nuclear speck)|go:"GO:0046784"(viral mRNA export from host cell nucleus)|interpro:IPR001680(WD40 repeat)|interpro:IPR013979(Eukaryotic translation initiation factor 2A, central region)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR020472|interpro:IPR024977|interpro:IPR036322|interpro:IPR040132|mint:Q96J01|rcsb pdb:7APK|reactome:R-HSA-159236|reactome:R-HSA-72187|reactome:R-HSA-73856|refseq:NP_115737.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:ulHudY1eLmIPQKfgdkXNoE1O5AM9606 rogid:ENG6Gf3Q6WsTn5qkASarueRR+qc9606 intact-crc:590585B07C635A2A|rigid:zEmay/Ws2PfPDD+lGwJ/1Gobf84 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q5VVQ6 uniprotkb:Q8NBS9 intact:EBI-2510804|ensembl:ENSP00000326813|uniprotkb:Q86T63|uniprotkb:B2RNX3|uniprotkb:Q5VVQ5|uniprotkb:Q9P1L8|uniprotkb:Q6ZRS6 intact:EBI-2510815|ensembl:ENSP00000369081|uniprotkb:Q8TCT2|uniprotkb:Q5TCQ0|uniprotkb:Q9BVH9|uniprotkb:Q8ND33|uniprotkb:B2RDM2 psi-mi:otu1_human(display_long)|uniprotkb:YOD1(gene name)|psi-mi:YOD1(display_short)|uniprotkb:DUBA8(gene name synonym)|uniprotkb:HIN7(gene name synonym)|uniprotkb:OTUD2(gene name synonym)|uniprotkb:OTU domain-containing protein 2(gene name synonym)|uniprotkb:DUBA-8(gene name synonym)|uniprotkb:HIV-1-induced protease 7(gene name synonym)|uniprotkb:PRO0907(orf name) psi-mi:txnd5_human(display_long)|uniprotkb:TXNDC5(gene name)|psi-mi:TXNDC5(display_short)|uniprotkb:TLP46(gene name synonym)|uniprotkb:Thioredoxin-like protein p46(gene name synonym)|uniprotkb:Endoplasmic reticulum resident protein 46(gene name synonym)|uniprotkb:UNQ364/PRO700(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510813|imex:IM-12079-59 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:4BOZ|reactome:R-HSA-5689896|rcsb pdb:4BOS|ensembl:ENSG00000180667(gene)|ensembl:ENST00000315927(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016236"(macroautophagy)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035523"(protein K29-linked deubiquitination)|go:"GO:0035871"(protein K11-linked deubiquitination)|go:"GO:0046872"(metal ion binding)|go:"GO:0061578"(Lys63-specific deubiquitinase activity)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:0101005"(deubiquitinase activity)|go:"GO:1904153"(negative regulation of retrograde protein transport, ER to cytosol)|go:"GO:1990167"(protein K27-linked deubiquitination)|go:"GO:1990168"(protein K33-linked deubiquitination)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR003323(Ovarian tumour, otubain)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR029071|interpro:IPR038765|interpro:IPR039138|rcsb pdb:4BOQ|refseq:NP_001263249.1|refseq:NP_061036.3 ensembl:ENSG00000239264(gene)|ensembl:ENST00000379757(transcript)|go:"GO:0003756"(protein disulfide isomerase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0070062"(extracellular exosome)|interpro:IPR005788(Disulphide isomerase)|interpro:IPR013766(Thioredoxin domain)|interpro:IPR017937|interpro:IPR036249|rcsb pdb:2DIZ|rcsb pdb:3UJ1|rcsb pdb:3UVT|rcsb pdb:3WGD|rcsb pdb:3WGE|rcsb pdb:3WGX|reactome:R-HSA-432720|reactome:R-HSA-432722|reactome:R-HSA-6798695|refseq:NP_001139021.1|refseq:NP_110437.2|dip:DIP-53700N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:ulHudY1eLmIPQKfgdkXNoE1O5AM9606 rogid:bz5VVWMPFLTRKwph60UFASjsFN49606 intact-crc:590585B07C635A2A|rigid:zEmay/Ws2PfPDD+lGwJ/1Gobf84 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8N6M0 uniprotkb:B4DPD5 intact:EBI-2510892|ensembl:ENSP00000384190|uniprotkb:B4DEY0|uniprotkb:Q9Y387|uniprotkb:A8K6I1|uniprotkb:Q9NTA4 intact:EBI-2510901 psi-mi:otu6b_human(display_long)|uniprotkb:OTUD6B(gene name)|psi-mi:OTUD6B(display_short)|uniprotkb:DUBA5(gene name synonym)|uniprotkb:DUBA-5(gene name synonym)|uniprotkb:OTU domain-containing protein 6B(gene name synonym)|uniprotkb:CGI-77(orf name) psi-mi:b4dpd5_human(display_long) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510899|imex:IM-12079-60 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000155100(gene)|ensembl:ENST00000404789(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0043248"(proteasome assembly)|go:"GO:0045727"(positive regulation of translation)|interpro:IPR003323(Ovarian tumour, otubain)|interpro:IPR038765|refseq:NP_057107.3|refseq:XP_011515431.2|refseq:NP_001273674.1 go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0019784"(NEDD8-specific protease activity)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0071108"(protein K48-linked deubiquitination)|interpro:IPR003323(Ovarian tumour, otubain)|interpro:IPR019400|interpro:IPR016615(Ubiquitin thioesterase Otubain)|interpro:IPR038765|interpro:IPR030298|interpro:IPR042467|interpro:IPR042468 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:04LzUJC/KXoSlb5LaciuO+9Sw+U9606 rogid:QcpTOcBTLNloXGWjcZ3pn/pZ3aI9606 intact-crc:908DC10596CFA2C3|rigid:FtAJkgHAGvyoLjyNpYLXlKugZf4 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8N6M0 uniprotkb:Q8N3C0 intact:EBI-2510892|ensembl:ENSP00000384190|uniprotkb:B4DEY0|uniprotkb:Q9Y387|uniprotkb:A8K6I1|uniprotkb:Q9NTA4 intact:EBI-1210710|uniprotkb:Q9NTR0|uniprotkb:O43738|uniprotkb:Q5VTN2|uniprotkb:Q9H1I9|uniprotkb:E7EW23|uniprotkb:Q4G1A0|uniprotkb:Q9H5A2|ensembl:ENSP00000358159 psi-mi:otu6b_human(display_long)|uniprotkb:OTUD6B(gene name)|psi-mi:OTUD6B(display_short)|uniprotkb:DUBA5(gene name synonym)|uniprotkb:DUBA-5(gene name synonym)|uniprotkb:OTU domain-containing protein 6B(gene name synonym)|uniprotkb:CGI-77(orf name) psi-mi:ascc3_human(display_long)|uniprotkb:ASCC3(gene name)|psi-mi:ASCC3(display_short)|uniprotkb:HELIC1(gene name synonym)|uniprotkb:ASC-1 complex subunit p200(gene name synonym)|uniprotkb:Trip4 complex subunit p200(gene name synonym)|uniprotkb:Helicase, ATP binding 1(gene name synonym)|uniprotkb:RQT2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510899|imex:IM-12079-60 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000155100(gene)|ensembl:ENST00000404789(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0043248"(proteasome assembly)|go:"GO:0045727"(positive regulation of translation)|interpro:IPR003323(Ovarian tumour, otubain)|interpro:IPR038765|refseq:NP_057107.3|refseq:XP_011515431.2|refseq:NP_001273674.1 refseq:NP_001271200.1|refseq:NP_006819.2|refseq:NP_071374.1|ensembl:ENSG00000112249(gene)|ensembl:ENST00000369162(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006307"(DNA dealkylation involved in DNA repair)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0043138"(3'-5' DNA helicase activity)|go:"GO:0099053"(activating signal cointegrator 1 complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR004179(Sec63)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR027417|interpro:IPR035892|interpro:IPR036388|interpro:IPR036390|mint:Q8N3C0|rcsb pdb:6YXQ|reactome:R-HSA-112126|go:"GO:0005829"(cytosol) psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:04LzUJC/KXoSlb5LaciuO+9Sw+U9606 rogid:HAdhxBtWHxdw7k0GkyqBtloVyPY9606 intact-crc:908DC10596CFA2C3|rigid:FtAJkgHAGvyoLjyNpYLXlKugZf4 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8N6M0 uniprotkb:Q86UE4 intact:EBI-2510892|ensembl:ENSP00000384190|uniprotkb:B4DEY0|uniprotkb:Q9Y387|uniprotkb:A8K6I1|uniprotkb:Q9NTA4 intact:EBI-1046588|ensembl:ENSP00000338235|uniprotkb:Q8TCX3|uniprotkb:Q6PK07|uniprotkb:Q05DH2|uniprotkb:Q52QU9 psi-mi:otu6b_human(display_long)|uniprotkb:OTUD6B(gene name)|psi-mi:OTUD6B(display_short)|uniprotkb:DUBA5(gene name synonym)|uniprotkb:DUBA-5(gene name synonym)|uniprotkb:OTU domain-containing protein 6B(gene name synonym)|uniprotkb:CGI-77(orf name) psi-mi:lyric_human(display_long)|uniprotkb:Lysine-rich CEACAM1 co-isolated protein(gene name synonym)|uniprotkb:3D3/LYRIC(gene name synonym)|uniprotkb:Metastasis adhesion protein(gene name synonym)|uniprotkb:Astrocyte elevated gene-1 protein(gene name synonym)|uniprotkb:MTDH(gene name)|psi-mi:MTDH(display_short)|uniprotkb:AEG1(gene name synonym)|uniprotkb:LYRIC(gene name synonym)|uniprotkb:Metadherin(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510899|imex:IM-12079-60 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000155100(gene)|ensembl:ENST00000404789(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0043248"(proteasome assembly)|go:"GO:0045727"(positive regulation of translation)|interpro:IPR003323(Ovarian tumour, otubain)|interpro:IPR038765|refseq:NP_057107.3|refseq:XP_011515431.2|refseq:NP_001273674.1 ensembl:ENSG00000147649(gene)|ensembl:ENST00000336273(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001650"(fibrillar center)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031965"(nuclear membrane)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046581"(intercellular canaliculus)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070830"(bicellular tight junction assembly)|interpro:IPR031402|mint:Q86UE4|rcsb pdb:4QMG|refseq:NP_848927.2 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:04LzUJC/KXoSlb5LaciuO+9Sw+U9606 rogid:daZhKhAOeoKGjfl0IXt1fZXn/I09606 intact-crc:908DC10596CFA2C3|rigid:FtAJkgHAGvyoLjyNpYLXlKugZf4 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8N6M0 uniprotkb:Q9H7B2 intact:EBI-2510892|ensembl:ENSP00000384190|uniprotkb:B4DEY0|uniprotkb:Q9Y387|uniprotkb:A8K6I1|uniprotkb:Q9NTA4 intact:EBI-1051960|uniprotkb:Q8N4A1|uniprotkb:Q5VXN1|ensembl:ENSP00000402338 psi-mi:otu6b_human(display_long)|uniprotkb:OTUD6B(gene name)|psi-mi:OTUD6B(display_short)|uniprotkb:DUBA5(gene name synonym)|uniprotkb:DUBA-5(gene name synonym)|uniprotkb:OTU domain-containing protein 6B(gene name synonym)|uniprotkb:CGI-77(orf name) psi-mi:rpf2_human(display_long)|uniprotkb:RPF2(gene name)|psi-mi:RPF2(display_short)|uniprotkb:BXDC1(gene name synonym)|uniprotkb:Ribosome biogenesis protein RPF2 homolog(gene name synonym)|uniprotkb:Brix domain-containing protein 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510899|imex:IM-12079-60 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000155100(gene)|ensembl:ENST00000404789(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0043248"(proteasome assembly)|go:"GO:0045727"(positive regulation of translation)|interpro:IPR003323(Ovarian tumour, otubain)|interpro:IPR038765|refseq:NP_057107.3|refseq:XP_011515431.2|refseq:NP_001273674.1 refseq:NP_115570.1|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0008097"(5S rRNA binding)|go:"GO:0019843"(rRNA binding)|go:"GO:0042273"(ribosomal large subunit biogenesis)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1902570"(protein localization to nucleolus)|interpro:IPR007109(Brix)|interpro:IPR039770|mint:Q9H7B2|ensembl:ENSG00000197498(gene)|ensembl:ENST00000441448(transcript)|go:"GO:0000027"(ribosomal large subunit assembly)|go:"GO:0000463"("maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)") psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:04LzUJC/KXoSlb5LaciuO+9Sw+U9606 rogid:CXU4CHQmcrISLS8GDIwEMGhiaQI9606 intact-crc:908DC10596CFA2C3|rigid:FtAJkgHAGvyoLjyNpYLXlKugZf4 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96G74 uniprotkb:Q1L5Z9 intact:EBI-723849|ensembl:ENSP00000156084|uniprotkb:Q4KMN9|uniprotkb:Q8N6T5|uniprotkb:Q9H650|uniprotkb:Q9H9U0|uniprotkb:Q9NT65|uniprotkb:G5E9D7|uniprotkb:B4DGG7 intact:EBI-2510853|ensembl:ENSP00000377086|uniprotkb:Q6ZSR4|uniprotkb:B9A006 psi-mi:otud5_human(display_long)|uniprotkb:Deubiquitinating enzyme A(gene name synonym)|uniprotkb:OTUD5(gene name)|psi-mi:OTUD5(display_short) psi-mi:lonf2_human(display_long)|uniprotkb:LONRF2(gene name)|psi-mi:LONRF2(display_short)|uniprotkb:RNF192(gene name synonym)|uniprotkb:RING finger protein 192(gene name synonym)|uniprotkb:Neuroblastoma apoptosis-related protease(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510851|imex:IM-12079-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001129629.1|refseq:NP_001129630.1|refseq:NP_060072.1|ensembl:ENSG00000068308(gene)|ensembl:ENST00000156084(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005829"(cytosol)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0061578"(Lys63-specific deubiquitinase activity)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0101005"(deubiquitinase activity)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1904515"(positive regulation of TORC2 signaling)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR003323(Ovarian tumour, otubain)|interpro:IPR031084|interpro:IPR038765|rcsb pdb:3PFY|rcsb pdb:3TMO|rcsb pdb:3TMP|go:"GO:0032480"(negative regulation of type I interferon production)|reactome:R-HSA-5689896|reactome:R-HSA-936440|refseq:NP_001129631.1|refseq:XP_006724600.1|dip:DIP-53541N ensembl:ENSG00000170500(gene)|ensembl:ENST00000393437(transcript)|go:"GO:0046872"(metal ion binding)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003111(Peptidase S16, lon N-terminal)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR015947(PUA-like)|interpro:IPR017907|interpro:IPR019734|interpro:IPR027370|refseq:NP_940863.3 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2017/12/08 rogid:wyLs+EQs9u1cdJPnFBJSKKilZjw9606 rogid:/xd4kiOry4bcSjKo/Uxva7QmdE09606 intact-crc:55D6C44A27A4C051|rigid:qGNIz79eMpbQJviLAddEQiTAAgc false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96G74 uniprotkb:P36969 intact:EBI-723849|ensembl:ENSP00000156084|uniprotkb:Q4KMN9|uniprotkb:Q8N6T5|uniprotkb:Q9H650|uniprotkb:Q9H9U0|uniprotkb:Q9NT65|uniprotkb:G5E9D7|uniprotkb:B4DGG7 intact:EBI-2510844|uniprotkb:O43381|uniprotkb:Q9UPK2|uniprotkb:Q6PJ59|ensembl:ENSP00000346103 psi-mi:otud5_human(display_long)|uniprotkb:Deubiquitinating enzyme A(gene name synonym)|uniprotkb:OTUD5(gene name)|psi-mi:OTUD5(display_short) psi-mi:gpx4_human(display_long)|uniprotkb:GPX4(gene name)|psi-mi:GPX4(display_short)|uniprotkb:Glutathione peroxidase 4(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510851|imex:IM-12079-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001129629.1|refseq:NP_001129630.1|refseq:NP_060072.1|ensembl:ENSG00000068308(gene)|ensembl:ENST00000156084(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005829"(cytosol)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0061578"(Lys63-specific deubiquitinase activity)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0101005"(deubiquitinase activity)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1904515"(positive regulation of TORC2 signaling)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR003323(Ovarian tumour, otubain)|interpro:IPR031084|interpro:IPR038765|rcsb pdb:3PFY|rcsb pdb:3TMO|rcsb pdb:3TMP|go:"GO:0032480"(negative regulation of type I interferon production)|reactome:R-HSA-5689896|reactome:R-HSA-936440|refseq:NP_001129631.1|refseq:XP_006724600.1|dip:DIP-53541N refseq:NP_002076.2|refseq:NP_001034936.1|dip:DIP-53543N|reactome:R-HSA-9023661|reactome:R-HSA-9020265|ensembl:ENSG00000167468(gene)|ensembl:ENST00000354171(transcript)|go:"GO:0004601"(peroxidase activity)|go:"GO:0004602"(glutathione peroxidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006644"(phospholipid metabolic process)|go:"GO:0006749"(glutathione metabolic process)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007568"(aging)|go:"GO:0008430"(selenium binding)|go:"GO:0019369"(arachidonic acid metabolic process)|go:"GO:0019372"(lipoxygenase pathway)|go:"GO:0032355"(response to estradiol)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042759"(long-chain fatty acid biosynthetic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0047066"(phospholipid-hydroperoxide glutathione peroxidase activity)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051258"(protein polymerization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0110076"(negative regulation of ferroptosis)|interpro:IPR000889(Glutathione peroxidase)|interpro:IPR029759|interpro:IPR029760|interpro:IPR036249|rcsb pdb:2GS3|rcsb pdb:2OBI|rcsb pdb:5H5Q|rcsb pdb:5H5R|rcsb pdb:5H5S|rcsb pdb:6ELW|rcsb pdb:6HKQ|rcsb pdb:6HN3|reactome:R-HSA-2142688|reactome:R-HSA-2142712|reactome:R-HSA-2142770|reactome:R-HSA-9018676|reactome:R-HSA-9018896 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2017/12/08 rogid:wyLs+EQs9u1cdJPnFBJSKKilZjw9606 rogid:SUjUUl4rV/SKmLkV6WOiM+nusio9606 intact-crc:55D6C44A27A4C051|rigid:qGNIz79eMpbQJviLAddEQiTAAgc false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96G74 uniprotkb:P04637 intact:EBI-723849|ensembl:ENSP00000156084|uniprotkb:Q4KMN9|uniprotkb:Q8N6T5|uniprotkb:Q9H650|uniprotkb:Q9H9U0|uniprotkb:Q9NT65|uniprotkb:G5E9D7|uniprotkb:B4DGG7 intact:EBI-366083|uniprotkb:Q15086|uniprotkb:Q15087|uniprotkb:Q15088|uniprotkb:Q16535|uniprotkb:Q16807|uniprotkb:Q16808|uniprotkb:Q16809|uniprotkb:Q16810|uniprotkb:Q16811|uniprotkb:Q16848|uniprotkb:Q86UG1|uniprotkb:Q8J016|uniprotkb:Q99659|uniprotkb:Q9BTM4|uniprotkb:Q9HAQ8|uniprotkb:Q9NP68|uniprotkb:Q9NPJ2|uniprotkb:Q9NZD0|uniprotkb:Q9UBI2|uniprotkb:Q9UQ61|ensembl:ENSP00000269305|ensembl:ENSP00000391478|intact:EBI-28980681|uniprotkb:Q2XN98|uniprotkb:Q3LRW1|uniprotkb:Q3LRW2|uniprotkb:Q3LRW3|uniprotkb:Q3LRW4|uniprotkb:Q3LRW5 psi-mi:otud5_human(display_long)|uniprotkb:Deubiquitinating enzyme A(gene name synonym)|uniprotkb:OTUD5(gene name)|psi-mi:OTUD5(display_short) psi-mi:p53_human(display_long)|uniprotkb:TP53(gene name)|psi-mi:TP53(display_short)|uniprotkb:P53(gene name synonym)|uniprotkb:Tumor suppressor p53(gene name synonym)|uniprotkb:Phosphoprotein p53(gene name synonym)|uniprotkb:Antigen NY-CO-13(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510851|imex:IM-12079-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001129629.1|refseq:NP_001129630.1|refseq:NP_060072.1|ensembl:ENSG00000068308(gene)|ensembl:ENST00000156084(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005829"(cytosol)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0061578"(Lys63-specific deubiquitinase activity)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0101005"(deubiquitinase activity)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1904515"(positive regulation of TORC2 signaling)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR003323(Ovarian tumour, otubain)|interpro:IPR031084|interpro:IPR038765|rcsb pdb:3PFY|rcsb pdb:3TMO|rcsb pdb:3TMP|go:"GO:0032480"(negative regulation of type I interferon production)|reactome:R-HSA-5689896|reactome:R-HSA-936440|refseq:NP_001129631.1|refseq:XP_006724600.1|dip:DIP-53541N refseq:NP_001263624.1|refseq:NP_001263625.1|ensembl:ENSG00000141510(gene)|ensembl:ENST00000269305(transcript)|ensembl:ENST00000445888(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0001094"(TFIID-class transcription factor complex binding)|go:"GO:0001216"(DNA-binding transcription activator activity)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001756"(somitogenesis)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0002020"(protease binding)|go:"GO:0002039"(p53 binding)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002309"(T cell proliferation involved in immune response)|go:"GO:0002360"(T cell lineage commitment)|go:"GO:0002326"(B cell lineage commitment)|go:"GO:0031497"(chromatin assembly)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034103"(regulation of tissue remodeling)|go:"GO:0034613"(cellular protein localization)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035033"(histone deacetylase regulator activity)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035690"|go:"GO:0035794"(positive regulation of mitochondrial membrane permeability)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036003"(positive regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0036310"(ATP-dependent DNA/DNA annealing activity)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0002931"(response to ischemia)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006914"(autophagy)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006977"(DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)|go:"GO:0006978"(DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator)|go:"GO:0006983"(ER overload response)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007369"(gastrulation)|go:"GO:0007406"(negative regulation of neuroblast proliferation)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0043504"(mitochondrial DNA repair)|go:"GO:0043516"(regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0043621"(protein self-association)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045899"(positive regulation of RNA polymerase II transcription preinitiation complex assembly)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0048512"(circadian behavior)|go:"GO:0048539"(bone marrow development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051097"(negative regulation of helicase activity)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0062100"(positive regulation of programmed necrotic cell death)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0060411"(cardiac septum morphogenesis)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070245"(positive regulation of thymocyte apoptotic process)|go:"GO:0070266"(necroptotic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0071494"(cellular response to UV-C)|go:"GO:0072331"(signal transduction by p53 class mediator)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0072717"(cellular response to actinomycin D)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0090343"(positive regulation of cell aging)|go:"GO:0090399"(replicative senescence)|go:"GO:0090403"(oxidative stress-induced premature senescence)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0097252"(oligodendrocyte apoptotic process)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0140296"(general transcription initiation factor binding)|go:"GO:1900119"(positive regulation of execution phase of apoptosis)|go:"GO:1901525"(negative regulation of mitophagy)|go:"GO:1902108"(regulation of mitochondrial membrane permeability involved in apoptotic process)|go:"GO:1902253"(regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904024"(negative regulation of glucose catabolic process to lactate via pyruvate)|go:"GO:1905856"(negative regulation of pentose-phosphate shunt)|go:"GO:1990144"(intrinsic apoptotic signaling pathway in response to hypoxia)|go:"GO:1990248"(regulation of transcription from RNA polymerase II promoter in response to DNA damage)|go:"GO:1990440"(positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000269"(regulation of fibroblast apoptotic process)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000772"(regulation of cellular senescence)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002117(p53 tumor antigen)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR010991(p53, tetramerisation)|interpro:IPR011615(p53, DNA-binding)|go:"GO:0007569"(cell aging)|go:"GO:0008104"(protein localization)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008156"(negative regulation of DNA replication)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009299"(mRNA transcription)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009651"(response to salt stress)|go:"GO:0010165"(response to X-ray)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0016032"(viral process)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016605"(PML body)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031065"(positive regulation of histone deacetylation)|interpro:IPR012346(p53 and RUNT-type transcription factor, DNA-binding)|interpro:IPR013872("p53 transactivation domain (TAD)")|interpro:IPR036674|interpro:IPR040926|rcsb pdb:2ATA|rcsb pdb:2B3G|rcsb pdb:2BIM|rcsb pdb:2BIN|rcsb pdb:2BIO|rcsb pdb:2BIP|rcsb pdb:2AHI|rcsb pdb:2BIQ|rcsb pdb:2F1X|rcsb pdb:2FEJ|rcsb pdb:2FOJ|rcsb pdb:2FOO|rcsb pdb:2GS0|rcsb pdb:2H1L|rcsb pdb:2H2D|rcsb pdb:2H2F|rcsb pdb:2H4F|rcsb pdb:2H4H|rcsb pdb:2H4J|rcsb pdb:2H59|rcsb pdb:2J0Z|rcsb pdb:2J10|rcsb pdb:2J11|rcsb pdb:2J1W|rcsb pdb:2J1X|rcsb pdb:2J1Y|rcsb pdb:2J1Z|rcsb pdb:2J20|rcsb pdb:2J21|rcsb pdb:2K8F|rcsb pdb:2L14|rcsb pdb:2LY4|rcsb pdb:2MEJ|rcsb pdb:2MWO|rcsb pdb:2MWP|rcsb pdb:2MWY|rcsb pdb:2MZD|rcsb pdb:2OCJ|rcsb pdb:2PCX|rcsb pdb:1A1U|rcsb pdb:1AIE|rcsb pdb:1C26|rcsb pdb:1DT7|rcsb pdb:1GZH|rcsb pdb:1H26|rcsb pdb:1HS5|rcsb pdb:1JSP|rcsb pdb:1KZY|rcsb pdb:1MA3|rcsb pdb:1OLG|rcsb pdb:1OLH|rcsb pdb:1PES|rcsb pdb:1PET|mint:P04637|rcsb pdb:1SAE|rcsb pdb:1SAF|rcsb pdb:1SAK|rcsb pdb:1SAL|rcsb pdb:1TSR|rcsb pdb:1TUP|rcsb pdb:1UOL|rcsb pdb:1XQH|rcsb pdb:1YC5|rcsb pdb:1YCQ|rcsb pdb:1YCR|rcsb pdb:1YCS|rcsb pdb:2AC0|rcsb pdb:2ADY|refseq:NP_000537.3|refseq:NP_001119584.1|refseq:NP_001119585.1|refseq:NP_001119586.1|refseq:NP_001119587.1|refseq:NP_001119588.1|refseq:NP_001119589.1|rcsb pdb:2RUK|rcsb pdb:2VUK|rcsb pdb:3Q06|rcsb pdb:2WGX|rcsb pdb:2X0U|rcsb pdb:2X0V|rcsb pdb:2X0W|rcsb pdb:2XWR|rcsb pdb:2YBG|rcsb pdb:2YDR|rcsb pdb:2Z5S|rcsb pdb:2Z5T|rcsb pdb:3SAK|rcsb pdb:3D05|rcsb pdb:3D06|rcsb pdb:3D07|rcsb pdb:3D08|rcsb pdb:3D09|rcsb pdb:3D0A|rcsb pdb:3DAB|rcsb pdb:3DAC|rcsb pdb:3IGK|rcsb pdb:3IGL|rcsb pdb:3KMD|rcsb pdb:3TG5|rcsb pdb:3KZ8|rcsb pdb:3LW1|rcsb pdb:3OQ5|rcsb pdb:3PDH|rcsb pdb:3Q01|rcsb pdb:3Q05|rcsb pdb:3TS8|rcsb pdb:3ZME|rcsb pdb:4AGM|rcsb pdb:4AGN|rcsb pdb:4AGO|rcsb pdb:4AGP|rcsb pdb:4AGQ|rcsb pdb:4BUZ|rcsb pdb:4BV2|rcsb pdb:4HFZ|rcsb pdb:4HJE|rcsb pdb:4IBQ|rcsb pdb:4IBS|rcsb pdb:4IBT|rcsb pdb:4IBU|rcsb pdb:4IBV|rcsb pdb:4IBW|rcsb pdb:4IBY|rcsb pdb:4IBZ|rcsb pdb:4IJT|rcsb pdb:4KVP|rcsb pdb:4LO9|rcsb pdb:4LOE|rcsb pdb:4LOF|rcsb pdb:4MZI|rcsb pdb:4MZR|rcsb pdb:4QO1|rcsb pdb:4RP6|rcsb pdb:4RP7|rcsb pdb:4X34|rcsb pdb:4XR8|rcsb pdb:4ZZJ|rcsb pdb:5A7B|rcsb pdb:5AB9|rcsb pdb:5ABA|rcsb pdb:4AGL|rcsb pdb:5AOI|rcsb pdb:5AOJ|rcsb pdb:5AOK|rcsb pdb:5AOL|rcsb pdb:5AOM|rcsb pdb:6XRE|rcsb pdb:7BWN|rcsb pdb:7DHY|rcsb pdb:7DHZ|rcsb pdb:7EL4|reactome:R-HSA-111448|reactome:R-HSA-139915|reactome:R-HSA-1912408|reactome:R-HSA-2559580|reactome:R-HSA-2559584|reactome:R-HSA-2559585|reactome:R-HSA-2559586|reactome:R-HSA-3232118|reactome:R-HSA-349425|reactome:R-HSA-390471|reactome:R-HSA-5620971|reactome:R-HSA-5628897|reactome:R-HSA-5689880|reactome:R-HSA-5689896|reactome:R-HSA-5693565|reactome:R-HSA-6785807|reactome:R-HSA-6796648|reactome:R-HSA-6803204|reactome:R-HSA-6803205|reactome:R-HSA-6803207|reactome:R-HSA-6803211|reactome:R-HSA-6804114|reactome:R-HSA-6804115|reactome:R-HSA-6804116|reactome:R-HSA-6804754|reactome:R-HSA-6804756|reactome:R-HSA-6804757|reactome:R-HSA-6804758|reactome:R-HSA-6804759|reactome:R-HSA-6804760|reactome:R-HSA-6811555|reactome:R-HSA-69473|reactome:R-HSA-69481|reactome:R-HSA-69541|reactome:R-HSA-69895|reactome:R-HSA-8852276|reactome:R-HSA-8853884|reactome:R-HSA-8941855|reactome:R-HSA-8943724|reactome:R-HSA-983231|rcsb pdb:5ECG|rcsb pdb:5G4M|rcsb pdb:5G4N|rcsb pdb:5BUA|rcsb pdb:5G4O|rcsb pdb:5HOU|rcsb pdb:5HP0|rcsb pdb:5HPD|rcsb pdb:5LAP|rcsb pdb:5LGY|rcsb pdb:5MCT|rcsb pdb:5MCU|rcsb pdb:5MCV|rcsb pdb:5MCW|rcsb pdb:5MF7|rcsb pdb:5MG7|rcsb pdb:5MHC|rcsb pdb:5MOC|rcsb pdb:5O1A|rcsb pdb:5O1B|rcsb pdb:5O1C|rcsb pdb:5O1D|rcsb pdb:5O1E|rcsb pdb:5O1F|rcsb pdb:5O1G|rcsb pdb:5O1H|rcsb pdb:5O1I|rcsb pdb:5OL0|rcsb pdb:5UN8|rcsb pdb:5XZC|rcsb pdb:6FF9|rcsb pdb:6FJ5|rcsb pdb:6GGA|rcsb pdb:6GGB|rcsb pdb:6GGC|rcsb pdb:6GGD|rcsb pdb:6GGE|rcsb pdb:6GGF|rcsb pdb:6LHD|rcsb pdb:6R5L|rcsb pdb:6RJZ|rcsb pdb:6RK8|rcsb pdb:6RKI|rcsb pdb:6RKK|rcsb pdb:6RKM|rcsb pdb:6RL3|rcsb pdb:6RL4|rcsb pdb:6RL6|rcsb pdb:6RM5|rcsb pdb:6RM7|rcsb pdb:6RWH|rcsb pdb:6RWI|rcsb pdb:6RWS|rcsb pdb:6RWU|rcsb pdb:6RX2|rcsb pdb:6RZ3|rcsb pdb:6S39|rcsb pdb:6S40|rcsb pdb:6S9Q|rcsb pdb:6SHZ|rcsb pdb:6SI0|rcsb pdb:6SI1|rcsb pdb:6SI2|rcsb pdb:6SI3|rcsb pdb:6SI4|rcsb pdb:6SIN|rcsb pdb:6SIO|rcsb pdb:6SIP|rcsb pdb:6SIQ|rcsb pdb:6SL6|rcsb pdb:6SLV|rcsb pdb:6T58|rcsb pdb:6V4F|rcsb pdb:6V4H|rcsb pdb:6VQO|rcsb pdb:6VR1|rcsb pdb:6VR5|rcsb pdb:6VRM|rcsb pdb:6VRN|rcsb pdb:6W51|rcsb pdb:6S3C|ensembl:ENSP00000269305|ensembl:ENST00000420246|ensembl:ENSP00000391127|ensembl:ENSP00000391478|ensembl:ENST00000455263|ensembl:ENSP00000398846|ensembl:ENST00000504290|ensembl:ENSP00000484409|ensembl:ENST00000504937|ensembl:ENSP00000481179|ensembl:ENST00000510385|ensembl:ENSP00000478499|ensembl:ENST00000610292|ensembl:ENSP00000478219|ensembl:ENST00000610538|ensembl:ENSP00000480868|ensembl:ENST00000619485|ensembl:ENSP00000482537|ensembl:ENST00000620739|ensembl:ENSP00000481638|ensembl:ENST00000622645|ensembl:ENSP00000482222|refseq:NP_001119590.1|refseq:NP_001263626.1|refseq:NP_001263627.1|refseq:NP_001263628.1|refseq:NP_001263689.1|refseq:NP_001263690.1|dip:DIP-368N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2017/12/08 rogid:wyLs+EQs9u1cdJPnFBJSKKilZjw9606 rogid:fGN3kSCGIpi/D6d/X5kaB0Xu8/k9606 intact-crc:55D6C44A27A4C051|rigid:qGNIz79eMpbQJviLAddEQiTAAgc false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96G74 uniprotkb:Q96G74 intact:EBI-723849|ensembl:ENSP00000156084|uniprotkb:Q4KMN9|uniprotkb:Q8N6T5|uniprotkb:Q9H650|uniprotkb:Q9H9U0|uniprotkb:Q9NT65|uniprotkb:G5E9D7|uniprotkb:B4DGG7 intact:EBI-723849|ensembl:ENSP00000156084|uniprotkb:Q4KMN9|uniprotkb:Q8N6T5|uniprotkb:Q9H650|uniprotkb:Q9H9U0|uniprotkb:Q9NT65|uniprotkb:G5E9D7|uniprotkb:B4DGG7 psi-mi:otud5_human(display_long)|uniprotkb:Deubiquitinating enzyme A(gene name synonym)|uniprotkb:OTUD5(gene name)|psi-mi:OTUD5(display_short) psi-mi:otud5_human(display_long)|uniprotkb:Deubiquitinating enzyme A(gene name synonym)|uniprotkb:OTUD5(gene name)|psi-mi:OTUD5(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510851|imex:IM-12079-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001129629.1|refseq:NP_001129630.1|refseq:NP_060072.1|ensembl:ENSG00000068308(gene)|ensembl:ENST00000156084(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005829"(cytosol)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0061578"(Lys63-specific deubiquitinase activity)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0101005"(deubiquitinase activity)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1904515"(positive regulation of TORC2 signaling)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR003323(Ovarian tumour, otubain)|interpro:IPR031084|interpro:IPR038765|rcsb pdb:3PFY|rcsb pdb:3TMO|rcsb pdb:3TMP|go:"GO:0032480"(negative regulation of type I interferon production)|reactome:R-HSA-5689896|reactome:R-HSA-936440|refseq:NP_001129631.1|refseq:XP_006724600.1|dip:DIP-53541N refseq:NP_001129629.1|refseq:NP_001129630.1|refseq:NP_060072.1|ensembl:ENSG00000068308(gene)|ensembl:ENST00000156084(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005829"(cytosol)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0061578"(Lys63-specific deubiquitinase activity)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0101005"(deubiquitinase activity)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1904515"(positive regulation of TORC2 signaling)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR003323(Ovarian tumour, otubain)|interpro:IPR031084|interpro:IPR038765|rcsb pdb:3PFY|rcsb pdb:3TMO|rcsb pdb:3TMP|go:"GO:0032480"(negative regulation of type I interferon production)|reactome:R-HSA-5689896|reactome:R-HSA-936440|refseq:NP_001129631.1|refseq:XP_006724600.1|dip:DIP-53541N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2017/12/08 rogid:wyLs+EQs9u1cdJPnFBJSKKilZjw9606 rogid:wyLs+EQs9u1cdJPnFBJSKKilZjw9606 intact-crc:55D6C44A27A4C051|rigid:qGNIz79eMpbQJviLAddEQiTAAgc false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96G74 uniprotkb:Q9NS86 intact:EBI-723849|ensembl:ENSP00000156084|uniprotkb:Q4KMN9|uniprotkb:Q8N6T5|uniprotkb:Q9H650|uniprotkb:Q9H9U0|uniprotkb:Q9NT65|uniprotkb:G5E9D7|uniprotkb:B4DGG7 intact:EBI-2510837|ensembl:ENSP00000254770|uniprotkb:Q8TCQ3|uniprotkb:Q9BSR1|uniprotkb:B2R8D4|uniprotkb:Q6NSL4 psi-mi:otud5_human(display_long)|uniprotkb:Deubiquitinating enzyme A(gene name synonym)|uniprotkb:OTUD5(gene name)|psi-mi:OTUD5(display_short) psi-mi:lanc2_human(display_long)|uniprotkb:LANCL2(gene name)|psi-mi:LANCL2(display_short)|uniprotkb:GPR69B(gene name synonym)|uniprotkb:TASP(gene name synonym)|uniprotkb:Testis-specific adriamycin sensitivity protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510851|imex:IM-12079-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001129629.1|refseq:NP_001129630.1|refseq:NP_060072.1|ensembl:ENSG00000068308(gene)|ensembl:ENST00000156084(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005829"(cytosol)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0061578"(Lys63-specific deubiquitinase activity)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0101005"(deubiquitinase activity)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1904515"(positive regulation of TORC2 signaling)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR003323(Ovarian tumour, otubain)|interpro:IPR031084|interpro:IPR038765|rcsb pdb:3PFY|rcsb pdb:3TMO|rcsb pdb:3TMP|go:"GO:0032480"(negative regulation of type I interferon production)|reactome:R-HSA-5689896|reactome:R-HSA-936440|refseq:NP_001129631.1|refseq:XP_006724600.1|dip:DIP-53541N ensembl:ENSG00000132434(gene)|ensembl:ENST00000254770(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0009789"(positive regulation of abscisic acid-activated signaling pathway)|go:"GO:0010314"(phosphatidylinositol-5-phosphate binding)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0032266"(phosphatidylinositol-3-phosphate binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|interpro:IPR007822(Lanthionine synthetase C-like)|interpro:IPR012341(Six-hairpin glycosidase)|interpro:IPR020464|mint:Q9NS86|rcsb pdb:6WQ1|refseq:NP_061167.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2017/12/08 rogid:wyLs+EQs9u1cdJPnFBJSKKilZjw9606 rogid:PkzdkGLvNrypmS0AERzZANWFPZ09606 intact-crc:55D6C44A27A4C051|rigid:qGNIz79eMpbQJviLAddEQiTAAgc false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96G74 uniprotkb:Q01105 intact:EBI-723849|ensembl:ENSP00000156084|uniprotkb:Q4KMN9|uniprotkb:Q8N6T5|uniprotkb:Q9H650|uniprotkb:Q9H9U0|uniprotkb:Q9NT65|uniprotkb:G5E9D7|uniprotkb:B4DGG7 intact:EBI-1053182|uniprotkb:A5A5H4|uniprotkb:Q15541|uniprotkb:Q5VXV1|uniprotkb:Q6FHZ5|intact:EBI-2559610|uniprotkb:A6NGV1|uniprotkb:B4DUE2|intact:EBI-4290953|uniprotkb:Q5VXV2|ensembl:ENSP00000361777 psi-mi:otud5_human(display_long)|uniprotkb:Deubiquitinating enzyme A(gene name synonym)|uniprotkb:OTUD5(gene name)|psi-mi:OTUD5(display_short) psi-mi:set_human(display_long)|uniprotkb:Phosphatase 2A inhibitor I2PP2A(gene name synonym)|uniprotkb:Template-activating factor I(gene name synonym)|uniprotkb:HLA-DR-associated protein II(gene name synonym)|uniprotkb:PHAPII(gene name synonym)|uniprotkb:Inhibitor of granzyme A-activated DNase(gene name synonym)|uniprotkb:SET(gene name)|psi-mi:SET(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510851|imex:IM-12079-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001129629.1|refseq:NP_001129630.1|refseq:NP_060072.1|ensembl:ENSG00000068308(gene)|ensembl:ENST00000156084(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005829"(cytosol)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0061578"(Lys63-specific deubiquitinase activity)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0101005"(deubiquitinase activity)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1904515"(positive regulation of TORC2 signaling)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR003323(Ovarian tumour, otubain)|interpro:IPR031084|interpro:IPR038765|rcsb pdb:3PFY|rcsb pdb:3TMO|rcsb pdb:3TMP|go:"GO:0032480"(negative regulation of type I interferon production)|reactome:R-HSA-5689896|reactome:R-HSA-936440|refseq:NP_001129631.1|refseq:XP_006724600.1|dip:DIP-53541N refseq:NP_001116293.1|refseq:NP_003002.2|dip:DIP-33561N|refseq:NP_001234930.1|refseq:NP_001234929.1|ensembl:ENSG00000119335(gene)|ensembl:ENST00000372692(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0004864"(protein phosphatase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006337"(nucleosome disassembly)|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042393"(histone binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|interpro:IPR002164("Nucleosome assembly protein (NAP)")|interpro:IPR037231|mint:Q01105|rcsb pdb:2E50|rcsb pdb:7MTO|reactome:R-HSA-2299718|reactome:R-HSA-450520|go:"GO:0035067"(negative regulation of histone acetylation) psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2017/12/08 rogid:wyLs+EQs9u1cdJPnFBJSKKilZjw9606 rogid:CBwf28rN/LSY/vhw7jxRHKP8q0k9606 intact-crc:55D6C44A27A4C051|rigid:qGNIz79eMpbQJviLAddEQiTAAgc false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96G74 uniprotkb:P13807 intact:EBI-723849|ensembl:ENSP00000156084|uniprotkb:Q4KMN9|uniprotkb:Q8N6T5|uniprotkb:Q9H650|uniprotkb:Q9H9U0|uniprotkb:Q9NT65|uniprotkb:G5E9D7|uniprotkb:B4DGG7 intact:EBI-740553|intact:EBI-963094|intact:EBI-2948518|uniprotkb:Q9BTT9|ensembl:ENSP00000317904 psi-mi:otud5_human(display_long)|uniprotkb:Deubiquitinating enzyme A(gene name synonym)|uniprotkb:OTUD5(gene name)|psi-mi:OTUD5(display_short) psi-mi:gys1_human(display_long)|uniprotkb:GYS1(gene name)|psi-mi:GYS1(display_short)|uniprotkb:GYS(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510851|imex:IM-12079-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001129629.1|refseq:NP_001129630.1|refseq:NP_060072.1|ensembl:ENSG00000068308(gene)|ensembl:ENST00000156084(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005829"(cytosol)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0061578"(Lys63-specific deubiquitinase activity)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0101005"(deubiquitinase activity)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1904515"(positive regulation of TORC2 signaling)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR003323(Ovarian tumour, otubain)|interpro:IPR031084|interpro:IPR038765|rcsb pdb:3PFY|rcsb pdb:3TMO|rcsb pdb:3TMP|go:"GO:0032480"(negative regulation of type I interferon production)|reactome:R-HSA-5689896|reactome:R-HSA-936440|refseq:NP_001129631.1|refseq:XP_006724600.1|dip:DIP-53541N refseq:NP_001155059.1|refseq:NP_002094.2|ensembl:ENSG00000104812(gene)|ensembl:ENST00000323798(transcript)|go:"GO:0004373"("glycogen (starch) synthase activity")|go:"GO:0005536"(glucose binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005978"(glycogen biosynthetic process)|go:"GO:0007507"(heart development)|go:"GO:0016020"(membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0019901"(protein kinase binding)|go:"GO:0061547"(glycogen synthase activity, transferring glucose-1-phosphate)|interpro:IPR008631(Glycogen synthase)|mint:P13807|reactome:R-HSA-3322077|reactome:R-HSA-3785653|reactome:R-HSA-3814836|reactome:R-HSA-3828062 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2017/12/08 rogid:wyLs+EQs9u1cdJPnFBJSKKilZjw9606 rogid:qJ6wzje5P3wnfVq0oaFQqhAIQ1Q9606 intact-crc:55D6C44A27A4C051|rigid:qGNIz79eMpbQJviLAddEQiTAAgc false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96G74 uniprotkb:P21333 intact:EBI-723849|ensembl:ENSP00000156084|uniprotkb:Q4KMN9|uniprotkb:Q8N6T5|uniprotkb:Q9H650|uniprotkb:Q9H9U0|uniprotkb:Q9NT65|uniprotkb:G5E9D7|uniprotkb:B4DGG7 intact:EBI-350432|uniprotkb:Q8NF52|intact:EBI-1103234|ensembl:ENSP00000358866|uniprotkb:Q5HY53|uniprotkb:Q5HY55|uniprotkb:E9KL45 psi-mi:otud5_human(display_long)|uniprotkb:Deubiquitinating enzyme A(gene name synonym)|uniprotkb:OTUD5(gene name)|psi-mi:OTUD5(display_short) psi-mi:flna_human(display_long)|uniprotkb:FLNA(gene name)|psi-mi:FLNA(display_short)|uniprotkb:FLN(gene name synonym)|uniprotkb:FLN1(gene name synonym)|uniprotkb:Alpha-filamin(gene name synonym)|uniprotkb:Filamin-1(gene name synonym)|uniprotkb:Endothelial actin-binding protein(gene name synonym)|uniprotkb:Actin-binding protein 280(gene name synonym)|uniprotkb:Non-muscle filamin(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510851|imex:IM-12079-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001129629.1|refseq:NP_001129630.1|refseq:NP_060072.1|ensembl:ENSG00000068308(gene)|ensembl:ENST00000156084(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005829"(cytosol)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0061578"(Lys63-specific deubiquitinase activity)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0101005"(deubiquitinase activity)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1904515"(positive regulation of TORC2 signaling)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR003323(Ovarian tumour, otubain)|interpro:IPR031084|interpro:IPR038765|rcsb pdb:3PFY|rcsb pdb:3TMO|rcsb pdb:3TMP|go:"GO:0032480"(negative regulation of type I interferon production)|reactome:R-HSA-5689896|reactome:R-HSA-936440|refseq:NP_001129631.1|refseq:XP_006724600.1|dip:DIP-53541N go:"GO:0007195"(adenylate cyclase-inhibiting dopamine receptor signaling pathway)|go:"GO:1902396"(protein localization to bicellular tight junction)|refseq:NP_001104026.1|refseq:NP_001447.2|ensembl:ENSG00000196924(gene)|ensembl:ENST00000369850(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003723"(RNA binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048680"(positive regulation of axon regeneration)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051015"(actin filament binding)|go:"GO:0051020"(GTPase binding)|go:"GO:0051220"(cytoplasmic sequestering of protein)|go:"GO:0051764"(actin crosslink formation)|go:"GO:0060271"(cilium assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:0071526"(semaphorin-plexin signaling pathway)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090042"(tubulin deacetylation)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:0097368"(establishment of Sertoli cell barrier)|go:"GO:0097440"(apical dendrite)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1901381"(positive regulation of potassium ion transmembrane transport)|go:"GO:0046332"(SMAD binding)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016479"(negative regulation of transcription by RNA polymerase I)|go:"GO:0019900"(kinase binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0021943"(formation of radial glial scaffolds)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030018"(Z disc)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031523"(Myb complex)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031852"(mu-type opioid receptor binding)|go:"GO:0032233"(positive regulation of actin filament bundle assembly)|go:"GO:0032432"(actin filament bundle)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0034988"(Fc-gamma receptor I complex binding)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043113"(receptor clustering)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044319"(wound healing, spreading of cells)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0045296"(cadherin binding)|reactome:R-HSA-114608|reactome:R-HSA-430116|reactome:R-HSA-446353|reactome:R-HSA-5627123|reactome:R-HSA-8983711|rcsb pdb:6EW1|go:"GO:1905031"(regulation of membrane repolarization during cardiac muscle cell action potential)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2001046"(positive regulation of integrin-mediated signaling pathway)|go:"GO:2001224"(positive regulation of neuron migration)|interpro:IPR001298(Filamin/ABP280 repeat)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017868|interpro:IPR036872|interpro:IPR044801|mint:P21333|rcsb pdb:2AAV|rcsb pdb:2BP3|rcsb pdb:2BRQ|rcsb pdb:2J3S|rcsb pdb:2JF1|rcsb pdb:2K3T|rcsb pdb:2K7P|rcsb pdb:2K7Q|rcsb pdb:2MTP|rcsb pdb:2W0P|rcsb pdb:2WFN|rcsb pdb:3CNK|rcsb pdb:3HOC|rcsb pdb:3HOP|rcsb pdb:3HOR|rcsb pdb:3ISW|rcsb pdb:3RGH|rcsb pdb:4M9P|rcsb pdb:4P3W|rcsb pdb:5XR1|rcsb pdb:6D8C|go:"GO:1905000"(regulation of membrane repolarization during atrial cardiac muscle cell action potential)|dip:DIP-1136N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2017/12/08 rogid:wyLs+EQs9u1cdJPnFBJSKKilZjw9606 rogid:ZxGK5OSMy8cNsyt7Ax2KXb8bn9M9606 intact-crc:55D6C44A27A4C051|rigid:qGNIz79eMpbQJviLAddEQiTAAgc false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96G74 uniprotkb:P62993 intact:EBI-723849|ensembl:ENSP00000156084|uniprotkb:Q4KMN9|uniprotkb:Q8N6T5|uniprotkb:Q9H650|uniprotkb:Q9H9U0|uniprotkb:Q9NT65|uniprotkb:G5E9D7|uniprotkb:B4DGG7 intact:EBI-401755|ensembl:ENSP00000339007|uniprotkb:P29354|uniprotkb:Q14450|uniprotkb:Q63057|uniprotkb:Q63059|ensembl:ENSP00000376345|ensembl:ENSP00000376347|ensembl:ENSP00000496913 psi-mi:otud5_human(display_long)|uniprotkb:Deubiquitinating enzyme A(gene name synonym)|uniprotkb:OTUD5(gene name)|psi-mi:OTUD5(display_short) psi-mi:grb2_human(display_long)|uniprotkb:GRB2(gene name)|psi-mi:GRB2(display_short)|uniprotkb:ASH(gene name synonym)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)|uniprotkb:Protein Ash(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510851|imex:IM-12079-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001129629.1|refseq:NP_001129630.1|refseq:NP_060072.1|ensembl:ENSG00000068308(gene)|ensembl:ENST00000156084(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005829"(cytosol)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0061578"(Lys63-specific deubiquitinase activity)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0101005"(deubiquitinase activity)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1904515"(positive regulation of TORC2 signaling)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR003323(Ovarian tumour, otubain)|interpro:IPR031084|interpro:IPR038765|rcsb pdb:3PFY|rcsb pdb:3TMO|rcsb pdb:3TMP|go:"GO:0032480"(negative regulation of type I interferon production)|reactome:R-HSA-5689896|reactome:R-HSA-936440|refseq:NP_001129631.1|refseq:XP_006724600.1|dip:DIP-53541N ensembl:ENSG00000177885(gene)|refseq:NP_002077.1|refseq:NP_987102.1|ensembl:ENST00000316804(transcript)|ensembl:ENST00000392562(transcript)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|ensembl:ENST00000392564(transcript)|ensembl:ENST00000648046(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031623"(receptor internalization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:P62993|rcsb pdb:1AZE|rcsb pdb:1BM2|rcsb pdb:1BMB|rcsb pdb:1CJ1|rcsb pdb:1FHS|rcsb pdb:1FYR|rcsb pdb:1GCQ|rcsb pdb:1GFC|rcsb pdb:1GFD|rcsb pdb:1GHU|rcsb pdb:1GRI|rcsb pdb:1IO6|rcsb pdb:1JYQ|rcsb pdb:1JYR|rcsb pdb:1JYU|rcsb pdb:1QG1|rcsb pdb:1TZE|rcsb pdb:1X0N|rcsb pdb:1ZFP|rcsb pdb:2AOA|rcsb pdb:2AOB|rcsb pdb:2H46|rcsb pdb:2H5K|rcsb pdb:2HUW|rcsb pdb:2VVK|rcsb pdb:2VWF|rcsb pdb:2W0Z|rcsb pdb:3C7I|rcsb pdb:3IMD|rcsb pdb:3IMJ|rcsb pdb:3IN7|rcsb pdb:3IN8|rcsb pdb:3KFJ|rcsb pdb:3MXC|rcsb pdb:3N7Y|rcsb pdb:3N84|rcsb pdb:3N8M|rcsb pdb:3OV1|rcsb pdb:3OVE|rcsb pdb:3MXY|rcsb pdb:3S8L|rcsb pdb:3S8N|rcsb pdb:3S8O|rcsb pdb:3WA4|rcsb pdb:4P9V|rcsb pdb:4P9Z|rcsb pdb:5CDW|rcsb pdb:6ICG|rcsb pdb:6ICH|rcsb pdb:6SDF|rcsb pdb:6VK2|rcsb pdb:6WM1|rcsb pdb:6WO2|reactome:R-HSA-109704|reactome:R-HSA-112412|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-1257604|reactome:R-HSA-1295596|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-167044|reactome:R-HSA-179812|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-182971|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-2029482|reactome:R-HSA-210993|reactome:R-HSA-2179392|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-354194|reactome:R-HSA-375165|reactome:R-HSA-388841|reactome:R-HSA-389359|reactome:R-HSA-391160|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654693|reactome:R-HSA-5654695|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654710|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5654720|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5663213|reactome:R-HSA-5673001|reactome:R-HSA-6807004|reactome:R-HSA-6811558|reactome:R-HSA-74749|reactome:R-HSA-74751|reactome:R-HSA-8851805|reactome:R-HSA-8851907|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8865999|reactome:R-HSA-8875360|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-8983432|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9028335|reactome:R-HSA-5654689|reactome:R-HSA-9028731|reactome:R-HSA-9034864|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9607240|reactome:R-HSA-9634285|reactome:R-HSA-9645135|reactome:R-HSA-9664422|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9702518|reactome:R-HSA-9703465|reactome:R-HSA-9703648|reactome:R-HSA-983695|dip:DIP-29229N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2017/12/08 rogid:wyLs+EQs9u1cdJPnFBJSKKilZjw9606 rogid:SLnslQ7NHbnuK06nMVuRvJpoOA49606 intact-crc:55D6C44A27A4C051|rigid:qGNIz79eMpbQJviLAddEQiTAAgc false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96G74 uniprotkb:Q9NRF8 intact:EBI-723849|ensembl:ENSP00000156084|uniprotkb:Q4KMN9|uniprotkb:Q8N6T5|uniprotkb:Q9H650|uniprotkb:Q9H9U0|uniprotkb:Q9NT65|uniprotkb:G5E9D7|uniprotkb:B4DGG7 intact:EBI-740874|ensembl:ENSP00000352222|ensembl:ENSP00000369590|ensembl:ENSP00000401264|uniprotkb:Q9BRI0|uniprotkb:Q9H809|uniprotkb:Q9H8K9|uniprotkb:B3KWM2 psi-mi:otud5_human(display_long)|uniprotkb:Deubiquitinating enzyme A(gene name synonym)|uniprotkb:OTUD5(gene name)|psi-mi:OTUD5(display_short) psi-mi:pyrg2_human(display_long)|uniprotkb:UTP--ammonia ligase 2(gene name synonym)|uniprotkb:CTP synthetase 2(gene name synonym)|uniprotkb:CTPS2(gene name)|psi-mi:CTPS2(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510851|imex:IM-12079-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001129629.1|refseq:NP_001129630.1|refseq:NP_060072.1|ensembl:ENSG00000068308(gene)|ensembl:ENST00000156084(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005829"(cytosol)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0061578"(Lys63-specific deubiquitinase activity)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0101005"(deubiquitinase activity)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1904515"(positive regulation of TORC2 signaling)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR003323(Ovarian tumour, otubain)|interpro:IPR031084|interpro:IPR038765|rcsb pdb:3PFY|rcsb pdb:3TMO|rcsb pdb:3TMP|go:"GO:0032480"(negative regulation of type I interferon production)|reactome:R-HSA-5689896|reactome:R-HSA-936440|refseq:NP_001129631.1|refseq:XP_006724600.1|dip:DIP-53541N ensembl:ENSG00000047230(gene)|refseq:NP_001137474.1|refseq:NP_062831.3|refseq:NP_787055.1|ensembl:ENST00000359276(transcript)|ensembl:ENST00000380241(transcript)|ensembl:ENST00000443824(transcript)|go:"GO:0003883"(CTP synthase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006220"(pyrimidine nucleotide metabolic process)|go:"GO:0006241"(CTP biosynthetic process)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0019856"(pyrimidine nucleobase biosynthetic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0044210"('de novo' CTP biosynthetic process)|go:"GO:0097268"(cytoophidium)|interpro:IPR004468(CTP synthase)|interpro:IPR017456(CTP synthase, N-terminal)|interpro:IPR017926|interpro:IPR027417|interpro:IPR029062|interpro:IPR033828|rcsb pdb:2V4U|rcsb pdb:2VKT|rcsb pdb:3IHL|rcsb pdb:6PK4|rcsb pdb:6PK7|reactome:R-HSA-499943|refseq:XP_006724566.1|refseq:XP_005274619.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2017/12/08 rogid:wyLs+EQs9u1cdJPnFBJSKKilZjw9606 rogid:BU/tvZTUS1d42+j0qSGAg7ND25Y9606 intact-crc:55D6C44A27A4C051|rigid:qGNIz79eMpbQJviLAddEQiTAAgc false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96G74 uniprotkb:P30613 intact:EBI-723849|ensembl:ENSP00000156084|uniprotkb:Q4KMN9|uniprotkb:Q8N6T5|uniprotkb:Q9H650|uniprotkb:Q9H9U0|uniprotkb:Q9NT65|uniprotkb:G5E9D7|uniprotkb:B4DGG7 intact:EBI-2117450|uniprotkb:P11973|uniprotkb:O75758|ensembl:ENSP00000339933|ensembl:ENSP00000459921 psi-mi:otud5_human(display_long)|uniprotkb:Deubiquitinating enzyme A(gene name synonym)|uniprotkb:OTUD5(gene name)|psi-mi:OTUD5(display_short) psi-mi:kpyr_human(display_long)|uniprotkb:Pyruvate kinase isozymes L/R(gene name synonym)|uniprotkb:PKLR(gene name)|psi-mi:PKLR(display_short)|uniprotkb:PK1(gene name synonym)|uniprotkb:PKL(gene name synonym)|uniprotkb:R-type/L-type pyruvate kinase(gene name synonym)|uniprotkb:Red cell/liver pyruvate kinase(gene name synonym)|uniprotkb:Pyruvate kinase 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510851|imex:IM-12079-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001129629.1|refseq:NP_001129630.1|refseq:NP_060072.1|ensembl:ENSG00000068308(gene)|ensembl:ENST00000156084(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005829"(cytosol)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0061578"(Lys63-specific deubiquitinase activity)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0101005"(deubiquitinase activity)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1904515"(positive regulation of TORC2 signaling)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR003323(Ovarian tumour, otubain)|interpro:IPR031084|interpro:IPR038765|rcsb pdb:3PFY|rcsb pdb:3TMO|rcsb pdb:3TMP|go:"GO:0032480"(negative regulation of type I interferon production)|reactome:R-HSA-5689896|reactome:R-HSA-936440|refseq:NP_001129631.1|refseq:XP_006724600.1|dip:DIP-53541N refseq:NP_000289.1|refseq:NP_870986.1|ensembl:ENSG00000143627(gene)|ensembl:ENSG00000262785(gene)|ensembl:ENST00000342741(transcript)|ensembl:ENST00000572740(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0004743"(pyruvate kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006096"(glycolytic process)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0007584"(response to nutrient)|go:"GO:0009408"(response to heat)|go:"GO:0009749"(response to glucose)|go:"GO:0010226"(response to lithium ion)|go:"GO:0016301"(kinase activity)|go:"GO:0030955"(potassium ion binding)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033198"(response to ATP)|go:"GO:0042866"(pyruvate biosynthetic process)|go:"GO:0051591"(response to cAMP)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071872"(cellular response to epinephrine stimulus)|interpro:IPR001697(Pyruvate kinase)|interpro:IPR011037(Pyruvate kinase, beta-barrel-like)|interpro:IPR015793(Pyruvate kinase, barrel)|interpro:IPR015795(Pyruvate kinase, C-terminal-like)|interpro:IPR015806(Pyruvate kinase, beta-barrel)|interpro:IPR015813(Pyruvate/Phosphoenolpyruvate kinase, catalytic core)|interpro:IPR018209|interpro:IPR036918|interpro:IPR040442|rcsb pdb:2VGB|rcsb pdb:2VGF|rcsb pdb:2VGG|rcsb pdb:2VGI|rcsb pdb:4IMA|rcsb pdb:4IP7|rcsb pdb:6NN4|rcsb pdb:6NN5|rcsb pdb:6NN7|rcsb pdb:6NN8|reactome:R-HSA-163765|reactome:R-HSA-210745|reactome:R-HSA-70171 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2017/12/08 rogid:wyLs+EQs9u1cdJPnFBJSKKilZjw9606 rogid:7Dw4NAJv4qwG9bqTpNccySqPvhY9606 intact-crc:55D6C44A27A4C051|rigid:qGNIz79eMpbQJviLAddEQiTAAgc false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96G74 uniprotkb:P26640 intact:EBI-723849|ensembl:ENSP00000156084|uniprotkb:Q4KMN9|uniprotkb:Q8N6T5|uniprotkb:Q9H650|uniprotkb:Q9H9U0|uniprotkb:Q9NT65|uniprotkb:G5E9D7|uniprotkb:B4DGG7 intact:EBI-355765|uniprotkb:Q5JQ90|uniprotkb:Q96E77|uniprotkb:Q9UQM2|uniprotkb:B4DZ61|uniprotkb:B0V1N1|ensembl:ENSP00000211402|ensembl:ENSP00000364815|ensembl:ENSP00000401121|ensembl:ENSP00000403359|ensembl:ENSP00000415316 psi-mi:otud5_human(display_long)|uniprotkb:Deubiquitinating enzyme A(gene name synonym)|uniprotkb:OTUD5(gene name)|psi-mi:OTUD5(display_short) psi-mi:syvc_human(display_long)|uniprotkb:VARS1(gene name)|psi-mi:VARS1(display_short)|uniprotkb:G7A(gene name synonym)|uniprotkb:Protein G7a(gene name synonym)|uniprotkb:VARS(gene name synonym)|uniprotkb:VARS2(gene name synonym)|uniprotkb:Valyl-tRNA synthetase(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510851|imex:IM-12079-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001129629.1|refseq:NP_001129630.1|refseq:NP_060072.1|ensembl:ENSG00000068308(gene)|ensembl:ENST00000156084(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005829"(cytosol)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0061578"(Lys63-specific deubiquitinase activity)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0101005"(deubiquitinase activity)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1904515"(positive regulation of TORC2 signaling)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR003323(Ovarian tumour, otubain)|interpro:IPR031084|interpro:IPR038765|rcsb pdb:3PFY|rcsb pdb:3TMO|rcsb pdb:3TMP|go:"GO:0032480"(negative regulation of type I interferon production)|reactome:R-HSA-5689896|reactome:R-HSA-936440|refseq:NP_001129631.1|refseq:XP_006724600.1|dip:DIP-53541N refseq:NP_006286.1|ensembl:ENSG00000096171(gene)|ensembl:ENSG00000204394(gene)|ensembl:ENSG00000224264(gene)|ensembl:ENSG00000226589(gene)|ensembl:ENSG00000231116(gene)|ensembl:ENST00000211402(transcript)|ensembl:ENST00000375663(transcript)|ensembl:ENST00000422694(transcript)|ensembl:ENST00000435657(transcript)|ensembl:ENST00000457796(transcript)|go:"GO:0002161"(aminoacyl-tRNA editing activity)|go:"GO:0004832"(valine-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006418"(tRNA aminoacylation for protein translation)|go:"GO:0006438"(valyl-tRNA aminoacylation)|interpro:IPR001412(Aminoacyl-tRNA synthetase, class I, conserved site)|interpro:IPR002300(Aminoacyl-tRNA synthetase, class Ia)|interpro:IPR002303(Valyl-tRNA synthetase, class Ia)|interpro:IPR004046(Glutathione S-transferase, C-terminal)|interpro:IPR009008(Valyl/Leucyl/Isoleucyl-tRNA synthetase, class Ia, editing)|interpro:IPR009080(Aminoacyl-tRNA synthetase, class 1a, anticodon-binding)|interpro:IPR010987(Glutathione S-transferase, C-terminal-like)|interpro:IPR013155(Valyl/Leucyl/Isoleucyl-tRNA synthetase, class I, anticodon-binding)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR033705|interpro:IPR036282|interpro:IPR037118|mint:P26640|reactome:R-HSA-379716 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2017/12/08 rogid:wyLs+EQs9u1cdJPnFBJSKKilZjw9606 rogid:aPfpK0/C2KpCsMOI0sjCreufI509606 intact-crc:55D6C44A27A4C051|rigid:qGNIz79eMpbQJviLAddEQiTAAgc false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96G74 uniprotkb:Q9HB71 intact:EBI-723849|ensembl:ENSP00000156084|uniprotkb:Q4KMN9|uniprotkb:Q8N6T5|uniprotkb:Q9H650|uniprotkb:Q9H9U0|uniprotkb:Q9NT65|uniprotkb:G5E9D7|uniprotkb:B4DGG7 intact:EBI-1047302|uniprotkb:O60666|ensembl:ENSP00000356652|uniprotkb:B2ZWH2|uniprotkb:Q5R371|uniprotkb:B3KSF1|uniprotkb:Q5R370 psi-mi:otud5_human(display_long)|uniprotkb:Deubiquitinating enzyme A(gene name synonym)|uniprotkb:OTUD5(gene name)|psi-mi:OTUD5(display_short) psi-mi:cybp_human(display_long)|uniprotkb:Siah-interacting protein(gene name synonym)|uniprotkb:S100A6-binding protein(gene name synonym)|uniprotkb:CACYBP(gene name)|psi-mi:CACYBP(display_short)|uniprotkb:S100A6BP(gene name synonym)|uniprotkb:SIP(gene name synonym)|uniprotkb:PNAS-107(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510851|imex:IM-12079-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001129629.1|refseq:NP_001129630.1|refseq:NP_060072.1|ensembl:ENSG00000068308(gene)|ensembl:ENST00000156084(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005829"(cytosol)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0061578"(Lys63-specific deubiquitinase activity)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0101005"(deubiquitinase activity)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1904515"(positive regulation of TORC2 signaling)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR003323(Ovarian tumour, otubain)|interpro:IPR031084|interpro:IPR038765|rcsb pdb:3PFY|rcsb pdb:3TMO|rcsb pdb:3TMP|go:"GO:0032480"(negative regulation of type I interferon production)|reactome:R-HSA-5689896|reactome:R-HSA-936440|refseq:NP_001129631.1|refseq:XP_006724600.1|dip:DIP-53541N go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR015120(Siah interacting protein, N terminal)|interpro:IPR037201|interpro:IPR037893|mint:Q9HB71|rcsb pdb:1X5M|rcsb pdb:2A25|rcsb pdb:2A26|go:"GO:0071277"(cellular response to calcium ion)|refseq:NP_001007215.1|refseq:NP_055227.1|ensembl:ENSG00000116161(gene)|ensembl:ENST00000367679(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0015631"(tubulin binding)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0044297"(cell body)|go:"GO:0044548"(S100 protein binding)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0060416"(response to growth hormone)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070062"(extracellular exosome)|refseq:XP_016856535.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2017/12/08 rogid:wyLs+EQs9u1cdJPnFBJSKKilZjw9606 rogid:mvv1o19mLHBS3FDnATyOFsDoZvk9606 intact-crc:55D6C44A27A4C051|rigid:qGNIz79eMpbQJviLAddEQiTAAgc false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96G74 uniprotkb:P51784 intact:EBI-723849|ensembl:ENSP00000156084|uniprotkb:Q4KMN9|uniprotkb:Q8N6T5|uniprotkb:Q9H650|uniprotkb:Q9H9U0|uniprotkb:Q9NT65|uniprotkb:G5E9D7|uniprotkb:B4DGG7 intact:EBI-306876|intact:EBI-1058416|uniprotkb:Q8IUG6|uniprotkb:Q9BWE1|uniprotkb:B2RTX1|ensembl:ENSP00000218348 psi-mi:otud5_human(display_long)|uniprotkb:Deubiquitinating enzyme A(gene name synonym)|uniprotkb:OTUD5(gene name)|psi-mi:OTUD5(display_short) psi-mi:ubp11_human(display_long)|uniprotkb:USP11(gene name)|psi-mi:USP11(display_short)|uniprotkb:UHX1(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 11(gene name synonym)|uniprotkb:Deubiquitinating enzyme 11(gene name synonym)|uniprotkb:Ubiquitin thioesterase 11(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510851|imex:IM-12079-9 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001129629.1|refseq:NP_001129630.1|refseq:NP_060072.1|ensembl:ENSG00000068308(gene)|ensembl:ENST00000156084(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005829"(cytosol)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0061578"(Lys63-specific deubiquitinase activity)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0101005"(deubiquitinase activity)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1904515"(positive regulation of TORC2 signaling)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR003323(Ovarian tumour, otubain)|interpro:IPR031084|interpro:IPR038765|rcsb pdb:3PFY|rcsb pdb:3TMO|rcsb pdb:3TMP|go:"GO:0032480"(negative regulation of type I interferon production)|reactome:R-HSA-5689896|reactome:R-HSA-936440|refseq:NP_001129631.1|refseq:XP_006724600.1|dip:DIP-53541N ensembl:ENSG00000102226(gene)|ensembl:ENST00000218348(transcript)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR018200|interpro:IPR028135|interpro:IPR028889|interpro:IPR029346|interpro:IPR035927|interpro:IPR038765|mint:P51784|rcsb pdb:4MEL|rcsb pdb:5OK6|reactome:R-HSA-390471|reactome:R-HSA-5689880|refseq:NP_004642.2|refseq:XP_011542290.1|refseq:XP_005272731.1|dip:DIP-27567N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2017/12/08 rogid:wyLs+EQs9u1cdJPnFBJSKKilZjw9606 rogid:OSJLLFBf1ofw8SC01p2iiIM1oJo9606 intact-crc:55D6C44A27A4C051|rigid:qGNIz79eMpbQJviLAddEQiTAAgc false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9NR21 uniprotkb:Q8TEB1 intact:EBI-748917|uniprotkb:Q68DS1|uniprotkb:Q8N5Y9|uniprotkb:B4DRQ0|ensembl:ENSP00000228820|uniprotkb:F8WBZ7 intact:EBI-2213388|uniprotkb:Q5D039|uniprotkb:Q86U00|uniprotkb:Q86U39|uniprotkb:Q8NDN2|uniprotkb:Q9H2J0|uniprotkb:Q9H3A3|uniprotkb:Q9H5C9|uniprotkb:D3DS56|uniprotkb:B3KQ83|ensembl:ENSP00000415556|ensembl:ENSP00000452898|ensembl:ENSP00000494282|ensembl:ENSP00000495416 psi-mi:par11_human(display_long)|uniprotkb:PARP11(gene name)|psi-mi:PARP11(display_short)|uniprotkb:C12orf6(gene name synonym)|uniprotkb:ADP-ribosyltransferase diphtheria toxin-like 11(gene name synonym)|uniprotkb:Poly [ADP-ribose] polymerase 11(gene name synonym) psi-mi:dca11_human(display_long)|uniprotkb:DCAF11(gene name)|psi-mi:DCAF11(display_short)|uniprotkb:GL014(orf name)|uniprotkb:PRO2389(orf name)|uniprotkb:WDR23(gene name synonym)|uniprotkb:WD repeat-containing protein 23(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510918|imex:IM-12079-10 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001273450.1|refseq:NP_001273451.1|refseq:NP_065100.2|refseq:XP_005253768.1|refseq:XP_011519272.1|refseq:XP_011519273.1|refseq:XP_011519275.1|refseq:XP_016875159.1|refseq:XP_016875160.1|ensembl:ENSG00000111224(gene)|ensembl:ENST00000228820(transcript)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006998"(nuclear envelope organization)|go:"GO:0007283"(spermatogenesis)|go:"GO:0015031"(protein transport)|go:"GO:0016604"(nuclear body)|go:"GO:0030154"(cell differentiation)|go:"GO:0051028"(mRNA transport)|go:"GO:0070213"(protein auto-ADP-ribosylation)|go:"GO:0140289"(protein mono-ADP-ribosylation)|go:"GO:1990404"(protein ADP-ribosylase activity)|interpro:IPR004170(WWE)|interpro:IPR012317("Poly(ADP-ribose) polymerase, catalytic region")|interpro:IPR037197|rcsb pdb:2DK6 refseq:NP_001156956.1|refseq:NP_079506.3|refseq:NP_852002.1|ensembl:ENSG00000100897(gene)|ensembl:ENSG00000284796(gene)|ensembl:ENST00000446197(transcript)|ensembl:ENST00000559115(transcript)|ensembl:ENST00000642239(transcript)|ensembl:ENST00000646568(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0080008"(Cul4-RING E3 ubiquitin ligase complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR017399(WD repeat protein 23)|interpro:IPR020472|interpro:IPR036322|mint:Q8TEB1|reactome:R-HSA-8951664 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:Trx2/F5euYxQbxo7rGNbvIKCnq89606 rogid:iQQ4lP7NSE1MIcskh1XBjj9CC0s9606 intact-crc:6E39D64B9DF80082|rigid:vn2rqRvxIiKXJscvYdmt/ePjT5s false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9NR21 uniprotkb:Q9Y508 intact:EBI-748917|uniprotkb:Q68DS1|uniprotkb:Q8N5Y9|uniprotkb:B4DRQ0|ensembl:ENSP00000228820|uniprotkb:F8WBZ7 intact:EBI-723587|uniprotkb:Q6N0B0|uniprotkb:B2RDQ9|uniprotkb:B4DWY5|uniprotkb:E1P627|ensembl:ENSP00000244061 psi-mi:par11_human(display_long)|uniprotkb:PARP11(gene name)|psi-mi:PARP11(display_short)|uniprotkb:C12orf6(gene name synonym)|uniprotkb:ADP-ribosyltransferase diphtheria toxin-like 11(gene name synonym)|uniprotkb:Poly [ADP-ribose] polymerase 11(gene name synonym) psi-mi:rn114_human(display_long)|uniprotkb:Zinc finger protein 313(gene name synonym)|uniprotkb:RNF114(gene name)|psi-mi:RNF114(display_short)|uniprotkb:ZNF313(gene name synonym)|uniprotkb:ZNF228(gene name synonym)|uniprotkb:Zinc finger protein 228(gene name synonym)|uniprotkb:RING finger protein 114(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase RNF114(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510918|imex:IM-12079-10 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001273450.1|refseq:NP_001273451.1|refseq:NP_065100.2|refseq:XP_005253768.1|refseq:XP_011519272.1|refseq:XP_011519273.1|refseq:XP_011519275.1|refseq:XP_016875159.1|refseq:XP_016875160.1|ensembl:ENSG00000111224(gene)|ensembl:ENST00000228820(transcript)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006998"(nuclear envelope organization)|go:"GO:0007283"(spermatogenesis)|go:"GO:0015031"(protein transport)|go:"GO:0016604"(nuclear body)|go:"GO:0030154"(cell differentiation)|go:"GO:0051028"(mRNA transport)|go:"GO:0070213"(protein auto-ADP-ribosylation)|go:"GO:0140289"(protein mono-ADP-ribosylation)|go:"GO:1990404"(protein ADP-ribosylase activity)|interpro:IPR004170(WWE)|interpro:IPR012317("Poly(ADP-ribose) polymerase, catalytic region")|interpro:IPR037197|rcsb pdb:2DK6 refseq:NP_061153.1|ensembl:ENSG00000124226(gene)|ensembl:ENST00000244061(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007283"(spermatogenesis)|go:"GO:0030154"(cell differentiation)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR008598(Drought induced 19)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR027370|interpro:IPR034734|interpro:IPR042716|reactome:R-HSA-983168 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:Trx2/F5euYxQbxo7rGNbvIKCnq89606 rogid:R1fX8xaGuIhy/M6cLzPeyfJBf649606 intact-crc:6E39D64B9DF80082|rigid:vn2rqRvxIiKXJscvYdmt/ePjT5s false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9NR21 uniprotkb:P61626 intact:EBI-748917|uniprotkb:Q68DS1|uniprotkb:Q8N5Y9|uniprotkb:B4DRQ0|ensembl:ENSP00000228820|uniprotkb:F8WBZ7 intact:EBI-355360|ensembl:ENSP00000261267|uniprotkb:P00695|uniprotkb:Q9UCF8|uniprotkb:Q13170 psi-mi:par11_human(display_long)|uniprotkb:PARP11(gene name)|psi-mi:PARP11(display_short)|uniprotkb:C12orf6(gene name synonym)|uniprotkb:ADP-ribosyltransferase diphtheria toxin-like 11(gene name synonym)|uniprotkb:Poly [ADP-ribose] polymerase 11(gene name synonym) psi-mi:lysc_human(display_long)|uniprotkb:LYZ(gene name)|psi-mi:LYZ(display_short)|uniprotkb:LZM(gene name synonym)|uniprotkb:1,4-beta-N-acetylmuramidase C(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510918|imex:IM-12079-10 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001273450.1|refseq:NP_001273451.1|refseq:NP_065100.2|refseq:XP_005253768.1|refseq:XP_011519272.1|refseq:XP_011519273.1|refseq:XP_011519275.1|refseq:XP_016875159.1|refseq:XP_016875160.1|ensembl:ENSG00000111224(gene)|ensembl:ENST00000228820(transcript)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006998"(nuclear envelope organization)|go:"GO:0007283"(spermatogenesis)|go:"GO:0015031"(protein transport)|go:"GO:0016604"(nuclear body)|go:"GO:0030154"(cell differentiation)|go:"GO:0051028"(mRNA transport)|go:"GO:0070213"(protein auto-ADP-ribosylation)|go:"GO:0140289"(protein mono-ADP-ribosylation)|go:"GO:1990404"(protein ADP-ribosylase activity)|interpro:IPR004170(WWE)|interpro:IPR012317("Poly(ADP-ribose) polymerase, catalytic region")|interpro:IPR037197|rcsb pdb:2DK6 ensembl:ENSG00000090382(gene)|refseq:NP_000230.1|rcsb pdb:1GB7|rcsb pdb:1GB8|rcsb pdb:1GB9|rcsb pdb:1GBO|rcsb pdb:1GBW|rcsb pdb:1GBX|rcsb pdb:1GBY|rcsb pdb:1GBZ|rcsb pdb:1GDW|rcsb pdb:1GDX|rcsb pdb:1GE0|rcsb pdb:1GE1|rcsb pdb:1GE2|rcsb pdb:1GE3|rcsb pdb:1GE4|rcsb pdb:1GEV|rcsb pdb:1GEZ|rcsb pdb:1GF0|rcsb pdb:1GF3|rcsb pdb:1GF4|rcsb pdb:1GF5|rcsb pdb:1GF6|rcsb pdb:1GF7|rcsb pdb:1GF8|rcsb pdb:1GF9|rcsb pdb:1GFA|rcsb pdb:1GFE|rcsb pdb:1GFG|rcsb pdb:1GFH|rcsb pdb:1GFJ|rcsb pdb:1GFK|rcsb pdb:1GFR|rcsb pdb:1GFT|rcsb pdb:1GFU|rcsb pdb:1GFV|rcsb pdb:1HNL|rcsb pdb:1I1Z|rcsb pdb:1I20|rcsb pdb:1I22|rcsb pdb:1INU|rcsb pdb:1IOC|rcsb pdb:1IP1|rcsb pdb:1IP2|rcsb pdb:1IP3|rcsb pdb:1IP4|rcsb pdb:1IP5|rcsb pdb:1IP6|rcsb pdb:1IP7|rcsb pdb:1IWT|rcsb pdb:1IWU|rcsb pdb:1IWV|rcsb pdb:1IWW|rcsb pdb:1IWX|rcsb pdb:1IWY|rcsb pdb:1IWZ|rcsb pdb:1IX0|rcsb pdb:1IY3|rcsb pdb:1IY4|rcsb pdb:1JKA|rcsb pdb:1JKB|rcsb pdb:1JKC|rcsb pdb:1JKD|rcsb pdb:1JSF|rcsb pdb:1JWR|rcsb pdb:1LAA|rcsb pdb:1LHH|rcsb pdb:1LHI|rcsb pdb:1LHJ|rcsb pdb:1LHK|rcsb pdb:1LHL|rcsb pdb:1LHM|rcsb pdb:1LMT|rcsb pdb:1LOZ|rcsb pdb:1LYY|rcsb pdb:1LZ1|rcsb pdb:1LZ4|rcsb pdb:1LZ5|rcsb pdb:1LZ6|rcsb pdb:1LZR|rcsb pdb:1LZS|rcsb pdb:1OP9|rcsb pdb:1OUA|rcsb pdb:1OUB|rcsb pdb:1OUC|rcsb pdb:1OUD|rcsb pdb:1OUE|rcsb pdb:1OUF|rcsb pdb:1OUG|rcsb pdb:1OUH|rcsb pdb:1OUI|rcsb pdb:1OUJ|rcsb pdb:1QSW|rcsb pdb:1RE2|rcsb pdb:1REM|rcsb pdb:1REX|rcsb pdb:1REY|rcsb pdb:1REZ|rcsb pdb:1TAY|rcsb pdb:1TBY|rcsb pdb:1TCY|rcsb pdb:1TDY|rcsb pdb:1UBZ|rcsb pdb:5LVK|rcsb pdb:6LFH|reactome:R-HSA-6798695|reactome:R-HSA-6803157|reactome:R-HSA-977225|rcsb pdb:1W08|rcsb pdb:1WQM|rcsb pdb:1WQN|rcsb pdb:1WQO|rcsb pdb:1WQP|rcsb pdb:1WQQ|rcsb pdb:1WQR|rcsb pdb:1YAM|rcsb pdb:1YAN|rcsb pdb:1YAO|rcsb pdb:1YAP|rcsb pdb:1YAQ|rcsb pdb:207L|rcsb pdb:208L|rcsb pdb:2BQA|rcsb pdb:2BQB|rcsb pdb:2BQC|rcsb pdb:2BQD|rcsb pdb:2BQE|rcsb pdb:2BQF|rcsb pdb:2BQG|rcsb pdb:2BQH|rcsb pdb:2BQI|rcsb pdb:2BQJ|rcsb pdb:2BQK|rcsb pdb:2BQL|rcsb pdb:2BQM|rcsb pdb:2BQN|rcsb pdb:2BQO|rcsb pdb:2HEA|rcsb pdb:2HEB|rcsb pdb:2HEC|rcsb pdb:2HED|rcsb pdb:2HEE|rcsb pdb:2HEF|rcsb pdb:2LHM|rcsb pdb:2MEA|rcsb pdb:2MEB|rcsb pdb:2MEC|rcsb pdb:2MED|rcsb pdb:2MEE|rcsb pdb:2MEF|rcsb pdb:2MEG|rcsb pdb:2MEH|rcsb pdb:2MEI|rcsb pdb:2NWD|rcsb pdb:2ZIJ|rcsb pdb:2ZIK|rcsb pdb:2ZIL|rcsb pdb:2ZWB|rcsb pdb:3EBA|rcsb pdb:3FE0|rcsb pdb:3LHM|rcsb pdb:3LN2|rcsb pdb:4I0C|rcsb pdb:4ML7|rcsb pdb:4R0P|rcsb pdb:5LSH|rcsb pdb:1B5X|rcsb pdb:1B5Y|rcsb pdb:1B5Z|rcsb pdb:1B7L|rcsb pdb:1B7M|rcsb pdb:1B7N|rcsb pdb:1B7O|rcsb pdb:1B7P|rcsb pdb:1B7Q|rcsb pdb:1B7R|rcsb pdb:1B7S|rcsb pdb:1BB3|rcsb pdb:1BB4|rcsb pdb:1BB5|rcsb pdb:1C43|rcsb pdb:1C45|rcsb pdb:1C46|rcsb pdb:1C7P|rcsb pdb:1CJ6|rcsb pdb:1CJ7|rcsb pdb:1CJ8|ensembl:ENST00000261267(transcript)|go:"GO:0001895"(retina homeostasis)|go:"GO:0003796"(lysozyme activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0008152"(metabolic process)|go:"GO:0019730"(antimicrobial humoral response)|go:"GO:0019835"(cytolysis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0035580"(specific granule lumen)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904724"(tertiary granule lumen)|interpro:IPR000974(Glycoside hydrolase, family 22, lysozyme)|interpro:IPR001916(Glycoside hydrolase, family 22)|interpro:IPR019799|interpro:IPR023346|interpro:IPR030056|mint:P61626|rcsb pdb:133L|rcsb pdb:134L|rcsb pdb:1B5U|rcsb pdb:1B5V|rcsb pdb:1B5W|rcsb pdb:1CJ9|rcsb pdb:1CKC|rcsb pdb:1CKD|rcsb pdb:1CKF|rcsb pdb:1CKG|rcsb pdb:1CKH|rcsb pdb:1D6P|rcsb pdb:1D6Q|rcsb pdb:1DI3|rcsb pdb:1DI4|rcsb pdb:1DI5|rcsb pdb:1EQ4|rcsb pdb:1EQ5|rcsb pdb:1EQE|rcsb pdb:1GAY|rcsb pdb:1GAZ|rcsb pdb:1GB0|rcsb pdb:1GB2|rcsb pdb:1GB3|rcsb pdb:1GB5|rcsb pdb:1GB6 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:Trx2/F5euYxQbxo7rGNbvIKCnq89606 rogid:jydNN9yuU9EYvnth+kv115svRxw9606 intact-crc:6E39D64B9DF80082|rigid:vn2rqRvxIiKXJscvYdmt/ePjT5s false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O00487 uniprotkb:P48556 intact:EBI-722193|uniprotkb:O00176|uniprotkb:B3KNW2|ensembl:ENSP00000386541 intact:EBI-359304|uniprotkb:Q6P1L7|uniprotkb:B4DX18|ensembl:ENSP00000215071|ensembl:ENSP00000481136 psi-mi:psde_human(display_long)|uniprotkb:26S proteasome regulatory subunit RPN11(gene name synonym)|uniprotkb:26S proteasome-associated PAD1 homolog 1(gene name synonym)|uniprotkb:PSMD14(gene name)|psi-mi:PSMD14(display_short)|uniprotkb:POH1(gene name synonym) psi-mi:psmd8_human(display_long)|uniprotkb:PSMD8(gene name)|psi-mi:PSMD8(display_short)|uniprotkb:26S proteasome regulatory subunit S14(gene name synonym)|uniprotkb:p31(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN12(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510932|imex:IM-12079-61 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005796.1|ensembl:ENSG00000115233(gene)|ensembl:ENST00000409682(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008541"(proteasome regulatory particle, lid subcomplex)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0031597"(cytosolic proteasome complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0046872"(metal ion binding)|go:"GO:0061133"(endopeptidase activator activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0061578"(Lys63-specific deubiquitinase activity)|go:"GO:0070122"(isopeptidase activity)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0070628"(proteasome binding)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR024969|interpro:IPR035299|interpro:IPR037518|mint:O00487|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VGZ|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHS|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5689901|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168 refseq:NP_002803.2|ensembl:ENSG00000099341(gene)|ensembl:ENST00000215071(transcript)|ensembl:ENST00000620216(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0008541"(proteasome regulatory particle, lid subcomplex)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR006746(26S proteasome non-ATPase regulatory subunit Rpn12)|interpro:IPR033464|mint:P48556|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5M32|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VGZ|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHS|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|reactome:R-HSA-180534 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:pSM+755ZbQisR5S0ZivcYBu9Bc49606 rogid:73qmlkzCwdeHlNzUy7vy7qmIok09606 intact-crc:51480F69D4B932C3|rigid:HjQRBSOl/Ross2rOkXjByHatFCg false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O00487 uniprotkb:O75832 intact:EBI-722193|uniprotkb:O00176|uniprotkb:B3KNW2|ensembl:ENSP00000386541 intact:EBI-752185|uniprotkb:Q8IZK9|uniprotkb:Q5U0B2|ensembl:ENSP00000217958 psi-mi:psde_human(display_long)|uniprotkb:26S proteasome regulatory subunit RPN11(gene name synonym)|uniprotkb:26S proteasome-associated PAD1 homolog 1(gene name synonym)|uniprotkb:PSMD14(gene name)|psi-mi:PSMD14(display_short)|uniprotkb:POH1(gene name synonym) psi-mi:psd10_human(display_long)|uniprotkb:26S proteasome regulatory subunit p28(gene name synonym)|uniprotkb:Gankyrin(gene name synonym)|uniprotkb:PSMD10(gene name)|psi-mi:PSMD10(display_short)|uniprotkb:"p28(GANK)"(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510932|imex:IM-12079-61 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005796.1|ensembl:ENSG00000115233(gene)|ensembl:ENST00000409682(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008541"(proteasome regulatory particle, lid subcomplex)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0031597"(cytosolic proteasome complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0046872"(metal ion binding)|go:"GO:0061133"(endopeptidase activator activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0061578"(Lys63-specific deubiquitinase activity)|go:"GO:0070122"(isopeptidase activity)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0070628"(proteasome binding)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR024969|interpro:IPR035299|interpro:IPR037518|mint:O00487|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VGZ|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHS|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5689901|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168 refseq:NP_002805.1|refseq:NP_736606.1|dip:DIP-39026N|ensembl:ENSG00000101843(gene)|ensembl:ENST00000217958(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000502"(proteasome complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0008134"(transcription factor binding)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0043518"(negative regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0070682"(proteasome regulatory particle assembly)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR036770|go:"GO:0007253"(cytoplasmic sequestering of NF-kappaB)|mint:O75832|rcsb pdb:1QYM|rcsb pdb:1TR4|rcsb pdb:1UOH|rcsb pdb:4NIK|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHJ|rcsb pdb:5VHM|rcsb pdb:5VHN|rcsb pdb:5VHO|rcsb pdb:5VHP|rcsb pdb:5VHQ|rcsb pdb:5VHR|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|interpro:IPR039334|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|reactome:R-HSA-8951664 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:pSM+755ZbQisR5S0ZivcYBu9Bc49606 rogid:HJ1dl0tNhvWH7pSVWKpadkqe8A09606 intact-crc:51480F69D4B932C3|rigid:HjQRBSOl/Ross2rOkXjByHatFCg false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O00487 uniprotkb:Q9Y6E3 intact:EBI-722193|uniprotkb:O00176|uniprotkb:B3KNW2|ensembl:ENSP00000386541 intact:EBI-2510934 psi-mi:psde_human(display_long)|uniprotkb:26S proteasome regulatory subunit RPN11(gene name synonym)|uniprotkb:26S proteasome-associated PAD1 homolog 1(gene name synonym)|uniprotkb:PSMD14(gene name)|psi-mi:PSMD14(display_short)|uniprotkb:POH1(gene name synonym) psi-mi:q9y6e3_human(display_long)|uniprotkb:26S proteasome regulatory subunit RPN9(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S11(gene name synonym)|uniprotkb:26S proteasome regulatory subunit p40.5(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510932|imex:IM-12079-61 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005796.1|ensembl:ENSG00000115233(gene)|ensembl:ENST00000409682(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008541"(proteasome regulatory particle, lid subcomplex)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0031597"(cytosolic proteasome complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0046872"(metal ion binding)|go:"GO:0061133"(endopeptidase activator activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0061578"(Lys63-specific deubiquitinase activity)|go:"GO:0070122"(isopeptidase activity)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0070628"(proteasome binding)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR024969|interpro:IPR035299|interpro:IPR037518|mint:O00487|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VGZ|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHS|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5689901|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168 interpro:IPR000717(Proteasome component region PCI)|interpro:IPR035298|interpro:IPR036390 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:pSM+755ZbQisR5S0ZivcYBu9Bc49606 rogid:NKwKM9L5kXEuzLqTMQonYBVjAhg9606 intact-crc:51480F69D4B932C3|rigid:HjQRBSOl/Ross2rOkXjByHatFCg false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O00487 uniprotkb:P35998 intact:EBI-722193|uniprotkb:O00176|uniprotkb:B3KNW2|ensembl:ENSP00000386541 intact:EBI-359710|uniprotkb:B7Z5E2|uniprotkb:A4D0Q1|uniprotkb:Q3LIA5|uniprotkb:Q9UDI3|ensembl:ENSP00000292644|ensembl:ENSP00000391211|ensembl:ENSP00000502939|ensembl:ENSP00000503179|ensembl:ENSP00000504608 psi-mi:psde_human(display_long)|uniprotkb:26S proteasome regulatory subunit RPN11(gene name synonym)|uniprotkb:26S proteasome-associated PAD1 homolog 1(gene name synonym)|uniprotkb:PSMD14(gene name)|psi-mi:PSMD14(display_short)|uniprotkb:POH1(gene name synonym) psi-mi:prs7_human(display_long)|uniprotkb:PSMC2(gene name)|psi-mi:PSMC2(display_short)|uniprotkb:MSS1(gene name synonym)|uniprotkb:Proteasome 26S subunit ATPase 2(gene name synonym)|uniprotkb:Protein MSS1(gene name synonym)|uniprotkb:26S proteasome AAA-ATPase subunit RPT1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510932|imex:IM-12079-61 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005796.1|ensembl:ENSG00000115233(gene)|ensembl:ENST00000409682(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008541"(proteasome regulatory particle, lid subcomplex)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0031597"(cytosolic proteasome complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0046872"(metal ion binding)|go:"GO:0061133"(endopeptidase activator activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0061578"(Lys63-specific deubiquitinase activity)|go:"GO:0070122"(isopeptidase activity)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0070628"(proteasome binding)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR024969|interpro:IPR035299|interpro:IPR037518|mint:O00487|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VGZ|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHS|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5689901|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168 refseq:NP_001191382.1|refseq:NP_002794.1|interpro:IPR005937(26S proteasome subunit P45)|interpro:IPR027417|interpro:IPR035245|interpro:IPR041569|mint:P35998|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4G|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|interpro:IPR003960(AAA ATPase, conserved site)|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VGZ|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHJ|rcsb pdb:5VHM|rcsb pdb:5VHN|rcsb pdb:5VHO|rcsb pdb:5VHP|ensembl:ENSG00000161057(gene)|ensembl:ENST00000292644(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|ensembl:ENST00000435765(transcript)|ensembl:ENST00000678493(transcript)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0016020"(membrane)|ensembl:ENST00000679205(transcript)|ensembl:ENST00000679341(transcript)|go:"GO:0017025"(TBP-class protein binding)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0036402"(proteasome-activating activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0000502"(proteasome complex)|go:"GO:0000932"(P-body)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0043197"(dendritic spine)|go:"GO:0045899"(positive regulation of RNA polymerase II transcription preinitiation complex assembly)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|rcsb pdb:5VHR|rcsb pdb:5VHS|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|rcsb pdb:5VHQ|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|reactome:R-HSA-5610780|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|dip:DIP-27554N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:pSM+755ZbQisR5S0ZivcYBu9Bc49606 rogid:ahQfjPKywP5DWNq3FB5XCjuqkJ09606 intact-crc:51480F69D4B932C3|rigid:HjQRBSOl/Ross2rOkXjByHatFCg false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O00487 uniprotkb:O43242 intact:EBI-722193|uniprotkb:O00176|uniprotkb:B3KNW2|ensembl:ENSP00000386541 intact:EBI-357622|uniprotkb:Q96EI2|uniprotkb:Q9BQA4|ensembl:ENSP00000264639|uniprotkb:B4DT72|uniprotkb:B3KMW9 psi-mi:psde_human(display_long)|uniprotkb:26S proteasome regulatory subunit RPN11(gene name synonym)|uniprotkb:26S proteasome-associated PAD1 homolog 1(gene name synonym)|uniprotkb:PSMD14(gene name)|psi-mi:PSMD14(display_short)|uniprotkb:POH1(gene name synonym) psi-mi:psmd3_human(display_long)|uniprotkb:PSMD3(gene name)|psi-mi:PSMD3(display_short)|uniprotkb:Proteasome subunit p58(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S3(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN3(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510932|imex:IM-12079-61 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005796.1|ensembl:ENSG00000115233(gene)|ensembl:ENST00000409682(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008541"(proteasome regulatory particle, lid subcomplex)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0031597"(cytosolic proteasome complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0046872"(metal ion binding)|go:"GO:0061133"(endopeptidase activator activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0061578"(Lys63-specific deubiquitinase activity)|go:"GO:0070122"(isopeptidase activity)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0070628"(proteasome binding)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR024969|interpro:IPR035299|interpro:IPR037518|mint:O00487|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VGZ|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHS|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5689901|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168 ensembl:ENSG00000108344(gene)|ensembl:ENST00000264639(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008541"(proteasome regulatory particle, lid subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013586(26S proteasome regulatory subunit, C-terminal)|interpro:IPR035267|interpro:IPR036390|mint:O43242|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VGZ|rcsb pdb:5VHF|reactome:R-HSA-174113|reactome:R-HSA-174154|rcsb pdb:5VHH|rcsb pdb:5VHI|reactome:R-HSA-174178|rcsb pdb:5VHS|reactome:R-HSA-174184|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6MSH|reactome:R-HSA-180534|rcsb pdb:6MSJ|reactome:R-HSA-180585|reactome:R-HSA-187577|rcsb pdb:6MSK|reactome:R-HSA-195253|reactome:R-HSA-202424|rcsb pdb:6WJD|reactome:R-HSA-211733|rcsb pdb:6WJN|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-174084|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5607761|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|reactome:R-HSA-8854050|refseq:NP_002800.2|dip:DIP-27571N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:pSM+755ZbQisR5S0ZivcYBu9Bc49606 rogid:C6CStW89nIAA3mzubyv5wfBwPHk9606 intact-crc:51480F69D4B932C3|rigid:HjQRBSOl/Ross2rOkXjByHatFCg false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O00487 uniprotkb:Q15008 intact:EBI-722193|uniprotkb:O00176|uniprotkb:B3KNW2|ensembl:ENSP00000386541 intact:EBI-359701|uniprotkb:E9PHI9|uniprotkb:A8K2E0|ensembl:ENSP00000295901|uniprotkb:Q6UV22 psi-mi:psde_human(display_long)|uniprotkb:26S proteasome regulatory subunit RPN11(gene name synonym)|uniprotkb:26S proteasome-associated PAD1 homolog 1(gene name synonym)|uniprotkb:PSMD14(gene name)|psi-mi:PSMD14(display_short)|uniprotkb:POH1(gene name synonym) psi-mi:psmd6_human(display_long)|uniprotkb:PSMD6(gene name)|psi-mi:PSMD6(display_short)|uniprotkb:KIAA0107(gene name synonym)|uniprotkb:PFAAP4(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S10(gene name synonym)|uniprotkb:p42A(gene name synonym)|uniprotkb:Proteasome regulatory particle subunit p44S10(gene name synonym)|uniprotkb:Phosphonoformate immuno-associated protein 4(gene name synonym)|uniprotkb:Breast cancer-associated protein SGA-113M(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN7(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510932|imex:IM-12079-61 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005796.1|ensembl:ENSG00000115233(gene)|ensembl:ENST00000409682(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008541"(proteasome regulatory particle, lid subcomplex)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0031597"(cytosolic proteasome complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0046872"(metal ion binding)|go:"GO:0061133"(endopeptidase activator activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0061578"(Lys63-specific deubiquitinase activity)|go:"GO:0070122"(isopeptidase activity)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0070628"(proteasome binding)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR024969|interpro:IPR035299|interpro:IPR037518|mint:O00487|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VGZ|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHS|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5689901|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168 refseq:NP_055629.1|ensembl:ENSG00000163636(gene)|ensembl:ENST00000295901(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019585|interpro:IPR035268|interpro:IPR036390|mint:Q15008|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VGZ|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHS|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSG|rcsb pdb:6MSH|reactome:R-HSA-5358346|reactome:R-HSA-1236978|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-1236974|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|reactome:R-HSA-69601|reactome:R-HSA-69481|refseq:NP_001258708.1|refseq:NP_001258709.1|refseq:NP_001258710.1|dip:DIP-27590N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:pSM+755ZbQisR5S0ZivcYBu9Bc49606 rogid:ULOM02v6J56vZLlAGn7wN3N6Efw9606 intact-crc:51480F69D4B932C3|rigid:HjQRBSOl/Ross2rOkXjByHatFCg false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O00487 uniprotkb:Q99460 intact:EBI-722193|uniprotkb:O00176|uniprotkb:B3KNW2|ensembl:ENSP00000386541 intact:EBI-357874|uniprotkb:Q24JU0|uniprotkb:Q53TI2|uniprotkb:Q6GMU5|uniprotkb:Q6P2P4|uniprotkb:Q6PJM7|uniprotkb:Q6PKG9|uniprotkb:B8ZZH9|uniprotkb:Q86VU1|uniprotkb:Q8IV79|ensembl:ENSP00000309474|ensembl:ENSP00000503068 psi-mi:psde_human(display_long)|uniprotkb:26S proteasome regulatory subunit RPN11(gene name synonym)|uniprotkb:26S proteasome-associated PAD1 homolog 1(gene name synonym)|uniprotkb:PSMD14(gene name)|psi-mi:PSMD14(display_short)|uniprotkb:POH1(gene name synonym) psi-mi:psmd1_human(display_long)|uniprotkb:PSMD1(gene name)|psi-mi:PSMD1(display_short)|uniprotkb:26S proteasome regulatory subunit RPN2(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S1(gene name synonym)|uniprotkb:26S proteasome subunit p112(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510932|imex:IM-12079-61 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005796.1|ensembl:ENSG00000115233(gene)|ensembl:ENST00000409682(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008541"(proteasome regulatory particle, lid subcomplex)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0031597"(cytosolic proteasome complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0046872"(metal ion binding)|go:"GO:0061133"(endopeptidase activator activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0061578"(Lys63-specific deubiquitinase activity)|go:"GO:0070122"(isopeptidase activity)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0070628"(proteasome binding)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR024969|interpro:IPR035299|interpro:IPR037518|mint:O00487|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VGZ|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHS|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5689901|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168 refseq:NP_001177966.1|refseq:NP_002798.2|dip:DIP-27548N|ensembl:ENSG00000173692(gene)|ensembl:ENST00000308696(transcript)|ensembl:ENST00000677230(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034515"(proteasome storage granule)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|interpro:IPR002015(Proteasome/cyclosome, regulatory subunit)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016642(26S proteasome regulatory complex, non-ATPase subcomplex, Rpn2/Psmd1 subunit)|interpro:IPR035266|interpro:IPR040623|mint:Q99460|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5V1Y|rcsb pdb:5V1Z|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VGZ|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHS|rcsb pdb:6CO4|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6OI4|rcsb pdb:6UYI|rcsb pdb:6UYJ|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-382556|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:pSM+755ZbQisR5S0ZivcYBu9Bc49606 rogid:aGYxoT30PhzvF/CiurQLDb8Ewrs9606 intact-crc:51480F69D4B932C3|rigid:HjQRBSOl/Ross2rOkXjByHatFCg false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O00487 uniprotkb:O00231 intact:EBI-722193|uniprotkb:O00176|uniprotkb:B3KNW2|ensembl:ENSP00000386541 intact:EBI-357816|uniprotkb:O00495|uniprotkb:A8K3I7|uniprotkb:E1P663|uniprotkb:Q53FT5|ensembl:ENSP00000261712|ensembl:ENSP00000393185|ensembl:ENSP00000497128 psi-mi:psde_human(display_long)|uniprotkb:26S proteasome regulatory subunit RPN11(gene name synonym)|uniprotkb:26S proteasome-associated PAD1 homolog 1(gene name synonym)|uniprotkb:PSMD14(gene name)|psi-mi:PSMD14(display_short)|uniprotkb:POH1(gene name synonym) psi-mi:psd11_human(display_long)|uniprotkb:PSMD11(gene name)|psi-mi:PSMD11(display_short)|uniprotkb:26S proteasome regulatory subunit S9(gene name synonym)|uniprotkb:26S proteasome regulatory subunit p44.5(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN6(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510932|imex:IM-12079-61 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005796.1|ensembl:ENSG00000115233(gene)|ensembl:ENST00000409682(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008541"(proteasome regulatory particle, lid subcomplex)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0031597"(cytosolic proteasome complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0046872"(metal ion binding)|go:"GO:0061133"(endopeptidase activator activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0061578"(Lys63-specific deubiquitinase activity)|go:"GO:0070122"(isopeptidase activity)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0070628"(proteasome binding)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR024969|interpro:IPR035299|interpro:IPR037518|mint:O00487|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VGZ|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHS|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5689901|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168 refseq:NP_002806.2|refseq:NP_001257411.1|ensembl:ENSG00000108671(gene)|ensembl:ENST00000261712(transcript)|ensembl:ENST00000457654(transcript)|ensembl:ENST00000649012(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008541"(proteasome regulatory particle, lid subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0043248"(proteasome assembly)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR035295|interpro:IPR036390|interpro:IPR040773|interpro:IPR040780|mint:O00231|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5M32|rcsb pdb:5LN3|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VGZ|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHS|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:pSM+755ZbQisR5S0ZivcYBu9Bc49606 rogid:BgQKXK7gMMihacRCI+g/pBnRN309606 intact-crc:51480F69D4B932C3|rigid:HjQRBSOl/Ross2rOkXjByHatFCg false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O00487 uniprotkb:P62191 intact:EBI-722193|uniprotkb:O00176|uniprotkb:B3KNW2|ensembl:ENSP00000386541 intact:EBI-357598|uniprotkb:P49014|uniprotkb:Q03527|uniprotkb:Q6IAW0|uniprotkb:Q96AZ3|ensembl:ENSP00000261303|uniprotkb:Q6NW36|uniprotkb:B4DR63 psi-mi:psde_human(display_long)|uniprotkb:26S proteasome regulatory subunit RPN11(gene name synonym)|uniprotkb:26S proteasome-associated PAD1 homolog 1(gene name synonym)|uniprotkb:PSMD14(gene name)|psi-mi:PSMD14(display_short)|uniprotkb:POH1(gene name synonym) psi-mi:prs4_human(display_long)|uniprotkb:PSMC1(gene name)|psi-mi:PSMC1(display_short)|uniprotkb:26S proteasome AAA-ATPase subunit RPT2(gene name synonym)|uniprotkb:Proteasome 26S subunit ATPase 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510932|imex:IM-12079-61 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005796.1|ensembl:ENSG00000115233(gene)|ensembl:ENST00000409682(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008541"(proteasome regulatory particle, lid subcomplex)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0031597"(cytosolic proteasome complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0046872"(metal ion binding)|go:"GO:0061133"(endopeptidase activator activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0061578"(Lys63-specific deubiquitinase activity)|go:"GO:0070122"(isopeptidase activity)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0070628"(proteasome binding)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR024969|interpro:IPR035299|interpro:IPR037518|mint:O00487|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VGZ|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHS|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5689901|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168 refseq:NP_002793.2|ensembl:ENST00000261303(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0017025"(TBP-class protein binding)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0030163"(protein catabolic process)|ensembl:ENSG00000100764(gene)|go:"GO:0036402"(proteasome-activating activity)|go:"GO:1901215"(negative regulation of neuron death)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR005937(26S proteasome subunit P45)|interpro:IPR027417|interpro:IPR032501|interpro:IPR035244|interpro:IPR041569|mint:P62191|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4G|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFQ|rcsb pdb:5VFU|rcsb pdb:5VGZ|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHJ|rcsb pdb:5VHM|rcsb pdb:5VHN|rcsb pdb:5VHO|rcsb pdb:5VHP|rcsb pdb:5VHQ|rcsb pdb:5VHR|rcsb pdb:5VHS|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-532668|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-8852276|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|refseq:NP_001317141.1|refseq:XP_016876959.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:pSM+755ZbQisR5S0ZivcYBu9Bc49606 rogid:oGEtU7Cv0qversbD3WQgAo5H9pM9606 intact-crc:51480F69D4B932C3|rigid:HjQRBSOl/Ross2rOkXjByHatFCg false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O00487 uniprotkb:Q96EN9 intact:EBI-722193|uniprotkb:O00176|uniprotkb:B3KNW2|ensembl:ENSP00000386541 intact:EBI-745810|uniprotkb:Q8NAX4|uniprotkb:Q9NWI0|ensembl:ENSP00000351422|intact:EBI-11084128|uniprotkb:E9PAS0 psi-mi:psde_human(display_long)|uniprotkb:26S proteasome regulatory subunit RPN11(gene name synonym)|uniprotkb:26S proteasome-associated PAD1 homolog 1(gene name synonym)|uniprotkb:PSMD14(gene name)|psi-mi:PSMD14(display_short)|uniprotkb:POH1(gene name synonym) psi-mi:rex1b_human(display_long)|uniprotkb:REX1BD(gene name)|psi-mi:REX1BD(display_short)|uniprotkb:C19orf60(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510932|imex:IM-12079-61 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005796.1|ensembl:ENSG00000115233(gene)|ensembl:ENST00000409682(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008541"(proteasome regulatory particle, lid subcomplex)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0031597"(cytosolic proteasome complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0046872"(metal ion binding)|go:"GO:0061133"(endopeptidase activator activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0061578"(Lys63-specific deubiquitinase activity)|go:"GO:0070122"(isopeptidase activity)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0070628"(proteasome binding)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR024969|interpro:IPR035299|interpro:IPR037518|mint:O00487|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VGZ|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHS|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5689901|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168 refseq:NP_001093888.1|refseq:NP_001093889.1|ensembl:ENSG00000006015(gene)|ensembl:ENST00000358607(transcript)|interpro:IPR039491 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:pSM+755ZbQisR5S0ZivcYBu9Bc49606 rogid:y/YOKlXvG7PSR+fFGaenSTvgxO09606 intact-crc:51480F69D4B932C3|rigid:HjQRBSOl/Ross2rOkXjByHatFCg false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O00487 uniprotkb:O00232 intact:EBI-722193|uniprotkb:O00176|uniprotkb:B3KNW2|ensembl:ENSP00000386541 intact:EBI-359733|uniprotkb:Q53HA2|uniprotkb:Q6P053|ensembl:ENSP00000348442|uniprotkb:A6NP15 psi-mi:psde_human(display_long)|uniprotkb:26S proteasome regulatory subunit RPN11(gene name synonym)|uniprotkb:26S proteasome-associated PAD1 homolog 1(gene name synonym)|uniprotkb:PSMD14(gene name)|psi-mi:PSMD14(display_short)|uniprotkb:POH1(gene name synonym) psi-mi:psd12_human(display_long)|uniprotkb:PSMD12(gene name)|psi-mi:PSMD12(display_short)|uniprotkb:26S proteasome regulatory subunit p55(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN5(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510932|imex:IM-12079-61 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005796.1|ensembl:ENSG00000115233(gene)|ensembl:ENST00000409682(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008541"(proteasome regulatory particle, lid subcomplex)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0031597"(cytosolic proteasome complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0046872"(metal ion binding)|go:"GO:0061133"(endopeptidase activator activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0061578"(Lys63-specific deubiquitinase activity)|go:"GO:0070122"(isopeptidase activity)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0070628"(proteasome binding)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR024969|interpro:IPR035299|interpro:IPR037518|mint:O00487|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VGZ|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHS|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5689901|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168 refseq:NP_002807.1|refseq:NP_001303270.1|ensembl:ENSG00000197170(gene)|ensembl:ENST00000356126(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0008541"(proteasome regulatory particle, lid subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0031595"(nuclear proteasome complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR035297|interpro:IPR036388|interpro:IPR036390|interpro:IPR040134|interpro:IPR040896|mint:O00232|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VGZ|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHS|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|rcsb pdb:5VFS|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-5687128|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|refseq:NP_777360.1|dip:DIP-27549N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:pSM+755ZbQisR5S0ZivcYBu9Bc49606 rogid:4tzcvfL/EqQRcUpoMtxVU0WC+TU9606 intact-crc:51480F69D4B932C3|rigid:HjQRBSOl/Ross2rOkXjByHatFCg false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O00487 uniprotkb:Q9P2R7 intact:EBI-722193|uniprotkb:O00176|uniprotkb:B3KNW2|ensembl:ENSP00000386541 intact:EBI-2269898|uniprotkb:O95194|uniprotkb:Q5T9Q4|uniprotkb:Q5T9Q6|uniprotkb:Q9NV21|uniprotkb:Q9NVP7|uniprotkb:B2RDE7|ensembl:ENSP00000494360|ensembl:ENSP00000494987 psi-mi:psde_human(display_long)|uniprotkb:26S proteasome regulatory subunit RPN11(gene name synonym)|uniprotkb:26S proteasome-associated PAD1 homolog 1(gene name synonym)|uniprotkb:PSMD14(gene name)|psi-mi:PSMD14(display_short)|uniprotkb:POH1(gene name synonym) psi-mi:sucb1_human(display_long)|uniprotkb:SUCLA2(gene name)|psi-mi:SUCLA2(display_short)|uniprotkb:ATP-specific succinyl-CoA synthetase subunit beta(gene name synonym)|uniprotkb:Succinyl-CoA synthetase beta-A chain(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510932|imex:IM-12079-61 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005796.1|ensembl:ENSG00000115233(gene)|ensembl:ENST00000409682(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008541"(proteasome regulatory particle, lid subcomplex)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0031597"(cytosolic proteasome complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0046872"(metal ion binding)|go:"GO:0061133"(endopeptidase activator activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0061578"(Lys63-specific deubiquitinase activity)|go:"GO:0070122"(isopeptidase activity)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0070628"(proteasome binding)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR024969|interpro:IPR035299|interpro:IPR037518|mint:O00487|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VGZ|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHS|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5689901|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168 refseq:NP_003841.1|ensembl:ENSG00000136143(gene)|ensembl:ENST00000643584(transcript)|ensembl:ENST00000646932(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004775"("succinate-CoA ligase (ADP-forming) activity")|go:"GO:0004776"("succinate-CoA ligase (GDP-forming) activity")|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006104"(succinyl-CoA metabolic process)|go:"GO:0006105"(succinate metabolic process)|go:"GO:0006781"(succinyl-CoA pathway)|go:"GO:0042709"(succinate-CoA ligase complex)|go:"GO:0070062"(extracellular exosome)|interpro:IPR005809(Succinyl-CoA synthetase, beta subunit)|interpro:IPR005811(ATP-citrate lyase/succinyl-CoA ligase)|interpro:IPR011761(ATP-grasp fold)|interpro:IPR013650(ATP-grasp fold, succinyl-CoA synthetase-type)|interpro:IPR013815(ATP-grasp fold, subdomain 1)|interpro:IPR016102(Succinyl-CoA synthetase-like)|interpro:IPR017866|interpro:IPR034723|mint:Q9P2R7|rcsb pdb:6G4Q|reactome:R-HSA-71403 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:pSM+755ZbQisR5S0ZivcYBu9Bc49606 rogid:I/FQp3c8ckxpxoyftKge2B5lDmI9606 intact-crc:51480F69D4B932C3|rigid:HjQRBSOl/Ross2rOkXjByHatFCg false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O00487 uniprotkb:P51665 intact:EBI-722193|uniprotkb:O00176|uniprotkb:B3KNW2|ensembl:ENSP00000386541 intact:EBI-357659|uniprotkb:Q6PKI2|uniprotkb:Q96E97|ensembl:ENSP00000219313|uniprotkb:D3DWS9 psi-mi:psde_human(display_long)|uniprotkb:26S proteasome regulatory subunit RPN11(gene name synonym)|uniprotkb:26S proteasome-associated PAD1 homolog 1(gene name synonym)|uniprotkb:PSMD14(gene name)|psi-mi:PSMD14(display_short)|uniprotkb:POH1(gene name synonym) psi-mi:psmd7_human(display_long)|uniprotkb:PSMD7(gene name)|psi-mi:PSMD7(display_short)|uniprotkb:MOV34L(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN8(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S12(gene name synonym)|uniprotkb:Proteasome subunit p40(gene name synonym)|uniprotkb:Mov34 protein homolog(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510932|imex:IM-12079-61 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005796.1|ensembl:ENSG00000115233(gene)|ensembl:ENST00000409682(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008541"(proteasome regulatory particle, lid subcomplex)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0031597"(cytosolic proteasome complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0046872"(metal ion binding)|go:"GO:0061133"(endopeptidase activator activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0061578"(Lys63-specific deubiquitinase activity)|go:"GO:0070122"(isopeptidase activity)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0070628"(proteasome binding)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR024969|interpro:IPR035299|interpro:IPR037518|mint:O00487|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VGZ|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHS|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5689901|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168 refseq:NP_002802.2|rcsb pdb:5T0J|ensembl:ENSG00000103035(gene)|ensembl:ENST00000219313(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0016020"(membrane)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070122"(isopeptidase activity)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR024969|interpro:IPR033858|interpro:IPR037518|mint:P51665|rcsb pdb:2O95|rcsb pdb:2O96|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VGZ|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHS|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-180534|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-195253|reactome:R-HSA-5676590|reactome:R-HSA-202424|reactome:R-HSA-5678895|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-2871837|reactome:R-HSA-5689880|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-6798695|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-68827|reactome:R-HSA-4641258|reactome:R-HSA-68949|reactome:R-HSA-5358346|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|dip:DIP-27572N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:pSM+755ZbQisR5S0ZivcYBu9Bc49606 rogid:HJaBTx4pIiSDIArqueuNRvhzVvU9606 intact-crc:51480F69D4B932C3|rigid:HjQRBSOl/Ross2rOkXjByHatFCg false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P51665 uniprotkb:O75832 intact:EBI-357659|uniprotkb:Q6PKI2|uniprotkb:Q96E97|ensembl:ENSP00000219313|uniprotkb:D3DWS9 intact:EBI-752185|uniprotkb:Q8IZK9|uniprotkb:Q5U0B2|ensembl:ENSP00000217958 psi-mi:psmd7_human(display_long)|uniprotkb:PSMD7(gene name)|psi-mi:PSMD7(display_short)|uniprotkb:MOV34L(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN8(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S12(gene name synonym)|uniprotkb:Proteasome subunit p40(gene name synonym)|uniprotkb:Mov34 protein homolog(gene name synonym) psi-mi:psd10_human(display_long)|uniprotkb:26S proteasome regulatory subunit p28(gene name synonym)|uniprotkb:Gankyrin(gene name synonym)|uniprotkb:PSMD10(gene name)|psi-mi:PSMD10(display_short)|uniprotkb:"p28(GANK)"(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510969|imex:IM-12079-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002802.2|rcsb pdb:5T0J|ensembl:ENSG00000103035(gene)|ensembl:ENST00000219313(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0016020"(membrane)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070122"(isopeptidase activity)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR024969|interpro:IPR033858|interpro:IPR037518|mint:P51665|rcsb pdb:2O95|rcsb pdb:2O96|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VGZ|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHS|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-180534|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-195253|reactome:R-HSA-5676590|reactome:R-HSA-202424|reactome:R-HSA-5678895|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-2871837|reactome:R-HSA-5689880|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-6798695|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-68827|reactome:R-HSA-4641258|reactome:R-HSA-68949|reactome:R-HSA-5358346|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|dip:DIP-27572N refseq:NP_002805.1|refseq:NP_736606.1|dip:DIP-39026N|ensembl:ENSG00000101843(gene)|ensembl:ENST00000217958(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000502"(proteasome complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0008134"(transcription factor binding)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0043518"(negative regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0070682"(proteasome regulatory particle assembly)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR036770|go:"GO:0007253"(cytoplasmic sequestering of NF-kappaB)|mint:O75832|rcsb pdb:1QYM|rcsb pdb:1TR4|rcsb pdb:1UOH|rcsb pdb:4NIK|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHJ|rcsb pdb:5VHM|rcsb pdb:5VHN|rcsb pdb:5VHO|rcsb pdb:5VHP|rcsb pdb:5VHQ|rcsb pdb:5VHR|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|interpro:IPR039334|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|reactome:R-HSA-8951664 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:HJaBTx4pIiSDIArqueuNRvhzVvU9606 rogid:HJ1dl0tNhvWH7pSVWKpadkqe8A09606 intact-crc:AAAE3F2EE90EF746|rigid:hduxRD9YTYnGMjMpW+DUy/4clxc false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P51665 uniprotkb:P48556 intact:EBI-357659|uniprotkb:Q6PKI2|uniprotkb:Q96E97|ensembl:ENSP00000219313|uniprotkb:D3DWS9 intact:EBI-359304|uniprotkb:Q6P1L7|uniprotkb:B4DX18|ensembl:ENSP00000215071|ensembl:ENSP00000481136 psi-mi:psmd7_human(display_long)|uniprotkb:PSMD7(gene name)|psi-mi:PSMD7(display_short)|uniprotkb:MOV34L(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN8(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S12(gene name synonym)|uniprotkb:Proteasome subunit p40(gene name synonym)|uniprotkb:Mov34 protein homolog(gene name synonym) psi-mi:psmd8_human(display_long)|uniprotkb:PSMD8(gene name)|psi-mi:PSMD8(display_short)|uniprotkb:26S proteasome regulatory subunit S14(gene name synonym)|uniprotkb:p31(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN12(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510969|imex:IM-12079-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002802.2|rcsb pdb:5T0J|ensembl:ENSG00000103035(gene)|ensembl:ENST00000219313(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0016020"(membrane)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070122"(isopeptidase activity)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR024969|interpro:IPR033858|interpro:IPR037518|mint:P51665|rcsb pdb:2O95|rcsb pdb:2O96|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VGZ|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHS|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-180534|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-195253|reactome:R-HSA-5676590|reactome:R-HSA-202424|reactome:R-HSA-5678895|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-2871837|reactome:R-HSA-5689880|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-6798695|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-68827|reactome:R-HSA-4641258|reactome:R-HSA-68949|reactome:R-HSA-5358346|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|dip:DIP-27572N refseq:NP_002803.2|ensembl:ENSG00000099341(gene)|ensembl:ENST00000215071(transcript)|ensembl:ENST00000620216(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0008541"(proteasome regulatory particle, lid subcomplex)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR006746(26S proteasome non-ATPase regulatory subunit Rpn12)|interpro:IPR033464|mint:P48556|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5M32|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VGZ|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHS|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|reactome:R-HSA-180534 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:HJaBTx4pIiSDIArqueuNRvhzVvU9606 rogid:73qmlkzCwdeHlNzUy7vy7qmIok09606 intact-crc:AAAE3F2EE90EF746|rigid:hduxRD9YTYnGMjMpW+DUy/4clxc false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P51665 uniprotkb:P62191 intact:EBI-357659|uniprotkb:Q6PKI2|uniprotkb:Q96E97|ensembl:ENSP00000219313|uniprotkb:D3DWS9 intact:EBI-357598|uniprotkb:P49014|uniprotkb:Q03527|uniprotkb:Q6IAW0|uniprotkb:Q96AZ3|ensembl:ENSP00000261303|uniprotkb:Q6NW36|uniprotkb:B4DR63 psi-mi:psmd7_human(display_long)|uniprotkb:PSMD7(gene name)|psi-mi:PSMD7(display_short)|uniprotkb:MOV34L(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN8(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S12(gene name synonym)|uniprotkb:Proteasome subunit p40(gene name synonym)|uniprotkb:Mov34 protein homolog(gene name synonym) psi-mi:prs4_human(display_long)|uniprotkb:PSMC1(gene name)|psi-mi:PSMC1(display_short)|uniprotkb:26S proteasome AAA-ATPase subunit RPT2(gene name synonym)|uniprotkb:Proteasome 26S subunit ATPase 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510969|imex:IM-12079-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002802.2|rcsb pdb:5T0J|ensembl:ENSG00000103035(gene)|ensembl:ENST00000219313(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0016020"(membrane)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070122"(isopeptidase activity)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR024969|interpro:IPR033858|interpro:IPR037518|mint:P51665|rcsb pdb:2O95|rcsb pdb:2O96|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VGZ|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHS|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-180534|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-195253|reactome:R-HSA-5676590|reactome:R-HSA-202424|reactome:R-HSA-5678895|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-2871837|reactome:R-HSA-5689880|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-6798695|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-68827|reactome:R-HSA-4641258|reactome:R-HSA-68949|reactome:R-HSA-5358346|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|dip:DIP-27572N refseq:NP_002793.2|ensembl:ENST00000261303(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0017025"(TBP-class protein binding)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0030163"(protein catabolic process)|ensembl:ENSG00000100764(gene)|go:"GO:0036402"(proteasome-activating activity)|go:"GO:1901215"(negative regulation of neuron death)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR005937(26S proteasome subunit P45)|interpro:IPR027417|interpro:IPR032501|interpro:IPR035244|interpro:IPR041569|mint:P62191|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4G|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFQ|rcsb pdb:5VFU|rcsb pdb:5VGZ|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHJ|rcsb pdb:5VHM|rcsb pdb:5VHN|rcsb pdb:5VHO|rcsb pdb:5VHP|rcsb pdb:5VHQ|rcsb pdb:5VHR|rcsb pdb:5VHS|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-532668|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-8852276|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|refseq:NP_001317141.1|refseq:XP_016876959.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:HJaBTx4pIiSDIArqueuNRvhzVvU9606 rogid:oGEtU7Cv0qversbD3WQgAo5H9pM9606 intact-crc:AAAE3F2EE90EF746|rigid:hduxRD9YTYnGMjMpW+DUy/4clxc false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P51665 uniprotkb:Q99460 intact:EBI-357659|uniprotkb:Q6PKI2|uniprotkb:Q96E97|ensembl:ENSP00000219313|uniprotkb:D3DWS9 intact:EBI-357874|uniprotkb:Q24JU0|uniprotkb:Q53TI2|uniprotkb:Q6GMU5|uniprotkb:Q6P2P4|uniprotkb:Q6PJM7|uniprotkb:Q6PKG9|uniprotkb:B8ZZH9|uniprotkb:Q86VU1|uniprotkb:Q8IV79|ensembl:ENSP00000309474|ensembl:ENSP00000503068 psi-mi:psmd7_human(display_long)|uniprotkb:PSMD7(gene name)|psi-mi:PSMD7(display_short)|uniprotkb:MOV34L(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN8(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S12(gene name synonym)|uniprotkb:Proteasome subunit p40(gene name synonym)|uniprotkb:Mov34 protein homolog(gene name synonym) psi-mi:psmd1_human(display_long)|uniprotkb:PSMD1(gene name)|psi-mi:PSMD1(display_short)|uniprotkb:26S proteasome regulatory subunit RPN2(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S1(gene name synonym)|uniprotkb:26S proteasome subunit p112(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510969|imex:IM-12079-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002802.2|rcsb pdb:5T0J|ensembl:ENSG00000103035(gene)|ensembl:ENST00000219313(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0016020"(membrane)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070122"(isopeptidase activity)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR024969|interpro:IPR033858|interpro:IPR037518|mint:P51665|rcsb pdb:2O95|rcsb pdb:2O96|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VGZ|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHS|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-180534|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-195253|reactome:R-HSA-5676590|reactome:R-HSA-202424|reactome:R-HSA-5678895|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-2871837|reactome:R-HSA-5689880|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-6798695|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-68827|reactome:R-HSA-4641258|reactome:R-HSA-68949|reactome:R-HSA-5358346|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|dip:DIP-27572N refseq:NP_001177966.1|refseq:NP_002798.2|dip:DIP-27548N|ensembl:ENSG00000173692(gene)|ensembl:ENST00000308696(transcript)|ensembl:ENST00000677230(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034515"(proteasome storage granule)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|interpro:IPR002015(Proteasome/cyclosome, regulatory subunit)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016642(26S proteasome regulatory complex, non-ATPase subcomplex, Rpn2/Psmd1 subunit)|interpro:IPR035266|interpro:IPR040623|mint:Q99460|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5V1Y|rcsb pdb:5V1Z|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VGZ|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHS|rcsb pdb:6CO4|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6OI4|rcsb pdb:6UYI|rcsb pdb:6UYJ|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-382556|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:HJaBTx4pIiSDIArqueuNRvhzVvU9606 rogid:aGYxoT30PhzvF/CiurQLDb8Ewrs9606 intact-crc:AAAE3F2EE90EF746|rigid:hduxRD9YTYnGMjMpW+DUy/4clxc false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P51665 uniprotkb:O00487 intact:EBI-357659|uniprotkb:Q6PKI2|uniprotkb:Q96E97|ensembl:ENSP00000219313|uniprotkb:D3DWS9 intact:EBI-722193|uniprotkb:O00176|uniprotkb:B3KNW2|ensembl:ENSP00000386541 psi-mi:psmd7_human(display_long)|uniprotkb:PSMD7(gene name)|psi-mi:PSMD7(display_short)|uniprotkb:MOV34L(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN8(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S12(gene name synonym)|uniprotkb:Proteasome subunit p40(gene name synonym)|uniprotkb:Mov34 protein homolog(gene name synonym) psi-mi:psde_human(display_long)|uniprotkb:26S proteasome regulatory subunit RPN11(gene name synonym)|uniprotkb:26S proteasome-associated PAD1 homolog 1(gene name synonym)|uniprotkb:PSMD14(gene name)|psi-mi:PSMD14(display_short)|uniprotkb:POH1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510969|imex:IM-12079-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002802.2|rcsb pdb:5T0J|ensembl:ENSG00000103035(gene)|ensembl:ENST00000219313(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0016020"(membrane)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070122"(isopeptidase activity)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR024969|interpro:IPR033858|interpro:IPR037518|mint:P51665|rcsb pdb:2O95|rcsb pdb:2O96|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VGZ|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHS|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-180534|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-195253|reactome:R-HSA-5676590|reactome:R-HSA-202424|reactome:R-HSA-5678895|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-2871837|reactome:R-HSA-5689880|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-6798695|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-68827|reactome:R-HSA-4641258|reactome:R-HSA-68949|reactome:R-HSA-5358346|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|dip:DIP-27572N refseq:NP_005796.1|ensembl:ENSG00000115233(gene)|ensembl:ENST00000409682(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008541"(proteasome regulatory particle, lid subcomplex)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0031597"(cytosolic proteasome complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0046872"(metal ion binding)|go:"GO:0061133"(endopeptidase activator activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0061578"(Lys63-specific deubiquitinase activity)|go:"GO:0070122"(isopeptidase activity)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0070628"(proteasome binding)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR024969|interpro:IPR035299|interpro:IPR037518|mint:O00487|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VGZ|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHS|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5689901|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:HJaBTx4pIiSDIArqueuNRvhzVvU9606 rogid:pSM+755ZbQisR5S0ZivcYBu9Bc49606 intact-crc:AAAE3F2EE90EF746|rigid:hduxRD9YTYnGMjMpW+DUy/4clxc false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P51665 uniprotkb:Q9Y6E3 intact:EBI-357659|uniprotkb:Q6PKI2|uniprotkb:Q96E97|ensembl:ENSP00000219313|uniprotkb:D3DWS9 intact:EBI-2510934 psi-mi:psmd7_human(display_long)|uniprotkb:PSMD7(gene name)|psi-mi:PSMD7(display_short)|uniprotkb:MOV34L(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN8(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S12(gene name synonym)|uniprotkb:Proteasome subunit p40(gene name synonym)|uniprotkb:Mov34 protein homolog(gene name synonym) psi-mi:q9y6e3_human(display_long)|uniprotkb:26S proteasome regulatory subunit RPN9(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S11(gene name synonym)|uniprotkb:26S proteasome regulatory subunit p40.5(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510969|imex:IM-12079-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002802.2|rcsb pdb:5T0J|ensembl:ENSG00000103035(gene)|ensembl:ENST00000219313(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0016020"(membrane)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070122"(isopeptidase activity)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR024969|interpro:IPR033858|interpro:IPR037518|mint:P51665|rcsb pdb:2O95|rcsb pdb:2O96|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VGZ|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHS|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-180534|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-195253|reactome:R-HSA-5676590|reactome:R-HSA-202424|reactome:R-HSA-5678895|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-2871837|reactome:R-HSA-5689880|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-6798695|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-68827|reactome:R-HSA-4641258|reactome:R-HSA-68949|reactome:R-HSA-5358346|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|dip:DIP-27572N interpro:IPR000717(Proteasome component region PCI)|interpro:IPR035298|interpro:IPR036390 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:HJaBTx4pIiSDIArqueuNRvhzVvU9606 rogid:NKwKM9L5kXEuzLqTMQonYBVjAhg9606 intact-crc:AAAE3F2EE90EF746|rigid:hduxRD9YTYnGMjMpW+DUy/4clxc false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P51665 uniprotkb:P35998 intact:EBI-357659|uniprotkb:Q6PKI2|uniprotkb:Q96E97|ensembl:ENSP00000219313|uniprotkb:D3DWS9 intact:EBI-359710|uniprotkb:B7Z5E2|uniprotkb:A4D0Q1|uniprotkb:Q3LIA5|uniprotkb:Q9UDI3|ensembl:ENSP00000292644|ensembl:ENSP00000391211|ensembl:ENSP00000502939|ensembl:ENSP00000503179|ensembl:ENSP00000504608 psi-mi:psmd7_human(display_long)|uniprotkb:PSMD7(gene name)|psi-mi:PSMD7(display_short)|uniprotkb:MOV34L(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN8(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S12(gene name synonym)|uniprotkb:Proteasome subunit p40(gene name synonym)|uniprotkb:Mov34 protein homolog(gene name synonym) psi-mi:prs7_human(display_long)|uniprotkb:PSMC2(gene name)|psi-mi:PSMC2(display_short)|uniprotkb:MSS1(gene name synonym)|uniprotkb:Proteasome 26S subunit ATPase 2(gene name synonym)|uniprotkb:Protein MSS1(gene name synonym)|uniprotkb:26S proteasome AAA-ATPase subunit RPT1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510969|imex:IM-12079-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002802.2|rcsb pdb:5T0J|ensembl:ENSG00000103035(gene)|ensembl:ENST00000219313(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0016020"(membrane)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070122"(isopeptidase activity)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR024969|interpro:IPR033858|interpro:IPR037518|mint:P51665|rcsb pdb:2O95|rcsb pdb:2O96|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VGZ|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHS|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-180534|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-195253|reactome:R-HSA-5676590|reactome:R-HSA-202424|reactome:R-HSA-5678895|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-2871837|reactome:R-HSA-5689880|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-6798695|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-68827|reactome:R-HSA-4641258|reactome:R-HSA-68949|reactome:R-HSA-5358346|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|dip:DIP-27572N refseq:NP_001191382.1|refseq:NP_002794.1|interpro:IPR005937(26S proteasome subunit P45)|interpro:IPR027417|interpro:IPR035245|interpro:IPR041569|mint:P35998|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4G|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|interpro:IPR003960(AAA ATPase, conserved site)|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VGZ|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHJ|rcsb pdb:5VHM|rcsb pdb:5VHN|rcsb pdb:5VHO|rcsb pdb:5VHP|ensembl:ENSG00000161057(gene)|ensembl:ENST00000292644(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|ensembl:ENST00000435765(transcript)|ensembl:ENST00000678493(transcript)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0016020"(membrane)|ensembl:ENST00000679205(transcript)|ensembl:ENST00000679341(transcript)|go:"GO:0017025"(TBP-class protein binding)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0036402"(proteasome-activating activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0000502"(proteasome complex)|go:"GO:0000932"(P-body)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0043197"(dendritic spine)|go:"GO:0045899"(positive regulation of RNA polymerase II transcription preinitiation complex assembly)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|rcsb pdb:5VHR|rcsb pdb:5VHS|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|rcsb pdb:5VHQ|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|reactome:R-HSA-5610780|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|dip:DIP-27554N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:HJaBTx4pIiSDIArqueuNRvhzVvU9606 rogid:ahQfjPKywP5DWNq3FB5XCjuqkJ09606 intact-crc:AAAE3F2EE90EF746|rigid:hduxRD9YTYnGMjMpW+DUy/4clxc false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P51665 uniprotkb:P62333 intact:EBI-357659|uniprotkb:Q6PKI2|uniprotkb:Q96E97|ensembl:ENSP00000219313|uniprotkb:D3DWS9 intact:EBI-357669|uniprotkb:Q92524|uniprotkb:P49719|uniprotkb:Q6IBU3|uniprotkb:B2R975|ensembl:ENSP00000401802 psi-mi:psmd7_human(display_long)|uniprotkb:PSMD7(gene name)|psi-mi:PSMD7(display_short)|uniprotkb:MOV34L(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN8(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S12(gene name synonym)|uniprotkb:Proteasome subunit p40(gene name synonym)|uniprotkb:Mov34 protein homolog(gene name synonym) psi-mi:prs10_human(display_long)|uniprotkb:PSMC6(gene name)|psi-mi:PSMC6(display_short)|uniprotkb:SUG2(gene name synonym)|uniprotkb:Proteasome 26S subunit ATPase 6(gene name synonym)|uniprotkb:Proteasome subunit p42(gene name synonym)|uniprotkb:26S proteasome AAA-ATPase subunit RPT4(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510969|imex:IM-12079-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002802.2|rcsb pdb:5T0J|ensembl:ENSG00000103035(gene)|ensembl:ENST00000219313(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0016020"(membrane)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070122"(isopeptidase activity)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR024969|interpro:IPR033858|interpro:IPR037518|mint:P51665|rcsb pdb:2O95|rcsb pdb:2O96|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VGZ|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHS|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-180534|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-195253|reactome:R-HSA-5676590|reactome:R-HSA-202424|reactome:R-HSA-5678895|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-2871837|reactome:R-HSA-5689880|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-6798695|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-68827|reactome:R-HSA-4641258|reactome:R-HSA-68949|reactome:R-HSA-5358346|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|dip:DIP-27572N refseq:NP_002797.3|ensembl:ENST00000445930(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|ensembl:ENSG00000100519(gene)|go:"GO:0005829"(cytosol)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031597"(cytosolic proteasome complex)|go:"GO:0036402"(proteasome-activating activity)|go:"GO:0042802"(identical protein binding)|interpro:IPR032501|interpro:IPR035263|interpro:IPR041569|mint:P62333|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4G|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VGZ|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHJ|rcsb pdb:5VHM|rcsb pdb:5VHN|rcsb pdb:5VHO|rcsb pdb:5VHP|rcsb pdb:5VHQ|rcsb pdb:5VHR|rcsb pdb:5VHS|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6WJN|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|go:"GO:0045899"(positive regulation of RNA polymerase II transcription preinitiation complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090261"(positive regulation of inclusion body assembly)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR005937(26S proteasome subunit P45)|interpro:IPR027417|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|reactome:R-HSA-75815|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-174184|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|dip:DIP-38150N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:HJaBTx4pIiSDIArqueuNRvhzVvU9606 rogid:QE8jzSEp1bpzhOi/oAAnV18QK249606 intact-crc:AAAE3F2EE90EF746|rigid:hduxRD9YTYnGMjMpW+DUy/4clxc false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P51665 uniprotkb:O43242 intact:EBI-357659|uniprotkb:Q6PKI2|uniprotkb:Q96E97|ensembl:ENSP00000219313|uniprotkb:D3DWS9 intact:EBI-357622|uniprotkb:Q96EI2|uniprotkb:Q9BQA4|ensembl:ENSP00000264639|uniprotkb:B4DT72|uniprotkb:B3KMW9 psi-mi:psmd7_human(display_long)|uniprotkb:PSMD7(gene name)|psi-mi:PSMD7(display_short)|uniprotkb:MOV34L(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN8(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S12(gene name synonym)|uniprotkb:Proteasome subunit p40(gene name synonym)|uniprotkb:Mov34 protein homolog(gene name synonym) psi-mi:psmd3_human(display_long)|uniprotkb:PSMD3(gene name)|psi-mi:PSMD3(display_short)|uniprotkb:Proteasome subunit p58(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S3(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN3(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510969|imex:IM-12079-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002802.2|rcsb pdb:5T0J|ensembl:ENSG00000103035(gene)|ensembl:ENST00000219313(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0016020"(membrane)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070122"(isopeptidase activity)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR024969|interpro:IPR033858|interpro:IPR037518|mint:P51665|rcsb pdb:2O95|rcsb pdb:2O96|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VGZ|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHS|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-180534|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-195253|reactome:R-HSA-5676590|reactome:R-HSA-202424|reactome:R-HSA-5678895|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-2871837|reactome:R-HSA-5689880|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-6798695|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-68827|reactome:R-HSA-4641258|reactome:R-HSA-68949|reactome:R-HSA-5358346|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|dip:DIP-27572N ensembl:ENSG00000108344(gene)|ensembl:ENST00000264639(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008541"(proteasome regulatory particle, lid subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013586(26S proteasome regulatory subunit, C-terminal)|interpro:IPR035267|interpro:IPR036390|mint:O43242|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VGZ|rcsb pdb:5VHF|reactome:R-HSA-174113|reactome:R-HSA-174154|rcsb pdb:5VHH|rcsb pdb:5VHI|reactome:R-HSA-174178|rcsb pdb:5VHS|reactome:R-HSA-174184|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6MSH|reactome:R-HSA-180534|rcsb pdb:6MSJ|reactome:R-HSA-180585|reactome:R-HSA-187577|rcsb pdb:6MSK|reactome:R-HSA-195253|reactome:R-HSA-202424|rcsb pdb:6WJD|reactome:R-HSA-211733|rcsb pdb:6WJN|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-174084|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5607761|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|reactome:R-HSA-8854050|refseq:NP_002800.2|dip:DIP-27571N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:HJaBTx4pIiSDIArqueuNRvhzVvU9606 rogid:C6CStW89nIAA3mzubyv5wfBwPHk9606 intact-crc:AAAE3F2EE90EF746|rigid:hduxRD9YTYnGMjMpW+DUy/4clxc false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P51665 uniprotkb:Q15008 intact:EBI-357659|uniprotkb:Q6PKI2|uniprotkb:Q96E97|ensembl:ENSP00000219313|uniprotkb:D3DWS9 intact:EBI-359701|uniprotkb:E9PHI9|uniprotkb:A8K2E0|ensembl:ENSP00000295901|uniprotkb:Q6UV22 psi-mi:psmd7_human(display_long)|uniprotkb:PSMD7(gene name)|psi-mi:PSMD7(display_short)|uniprotkb:MOV34L(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN8(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S12(gene name synonym)|uniprotkb:Proteasome subunit p40(gene name synonym)|uniprotkb:Mov34 protein homolog(gene name synonym) psi-mi:psmd6_human(display_long)|uniprotkb:PSMD6(gene name)|psi-mi:PSMD6(display_short)|uniprotkb:KIAA0107(gene name synonym)|uniprotkb:PFAAP4(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S10(gene name synonym)|uniprotkb:p42A(gene name synonym)|uniprotkb:Proteasome regulatory particle subunit p44S10(gene name synonym)|uniprotkb:Phosphonoformate immuno-associated protein 4(gene name synonym)|uniprotkb:Breast cancer-associated protein SGA-113M(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN7(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510969|imex:IM-12079-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002802.2|rcsb pdb:5T0J|ensembl:ENSG00000103035(gene)|ensembl:ENST00000219313(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0016020"(membrane)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070122"(isopeptidase activity)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR024969|interpro:IPR033858|interpro:IPR037518|mint:P51665|rcsb pdb:2O95|rcsb pdb:2O96|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VGZ|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHS|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-180534|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-195253|reactome:R-HSA-5676590|reactome:R-HSA-202424|reactome:R-HSA-5678895|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-2871837|reactome:R-HSA-5689880|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-6798695|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-68827|reactome:R-HSA-4641258|reactome:R-HSA-68949|reactome:R-HSA-5358346|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|dip:DIP-27572N refseq:NP_055629.1|ensembl:ENSG00000163636(gene)|ensembl:ENST00000295901(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019585|interpro:IPR035268|interpro:IPR036390|mint:Q15008|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VGZ|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHS|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSG|rcsb pdb:6MSH|reactome:R-HSA-5358346|reactome:R-HSA-1236978|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-1236974|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|reactome:R-HSA-69601|reactome:R-HSA-69481|refseq:NP_001258708.1|refseq:NP_001258709.1|refseq:NP_001258710.1|dip:DIP-27590N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:HJaBTx4pIiSDIArqueuNRvhzVvU9606 rogid:ULOM02v6J56vZLlAGn7wN3N6Efw9606 intact-crc:AAAE3F2EE90EF746|rigid:hduxRD9YTYnGMjMpW+DUy/4clxc false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P51665 uniprotkb:P43686 intact:EBI-357659|uniprotkb:Q6PKI2|uniprotkb:Q96E97|ensembl:ENSP00000219313|uniprotkb:D3DWS9 intact:EBI-743997|uniprotkb:Q96FV5|uniprotkb:Q9UBM3|uniprotkb:Q9UEX3|ensembl:ENSP00000157812|ensembl:ENSP00000487367 psi-mi:psmd7_human(display_long)|uniprotkb:PSMD7(gene name)|psi-mi:PSMD7(display_short)|uniprotkb:MOV34L(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN8(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S12(gene name synonym)|uniprotkb:Proteasome subunit p40(gene name synonym)|uniprotkb:Mov34 protein homolog(gene name synonym) psi-mi:prs6b_human(display_long)|uniprotkb:Proteasome 26S subunit ATPase 4(gene name synonym)|uniprotkb:MB67-interacting protein(gene name synonym)|uniprotkb:PSMC4(gene name)|psi-mi:PSMC4(display_short)|uniprotkb:TBP7(gene name synonym)|uniprotkb:MIP224(gene name synonym)|uniprotkb:Tat-binding protein 7(gene name synonym)|uniprotkb:26S proteasome AAA-ATPase subunit RPT3(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510969|imex:IM-12079-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002802.2|rcsb pdb:5T0J|ensembl:ENSG00000103035(gene)|ensembl:ENST00000219313(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0016020"(membrane)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070122"(isopeptidase activity)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR024969|interpro:IPR033858|interpro:IPR037518|mint:P51665|rcsb pdb:2O95|rcsb pdb:2O96|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VGZ|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHS|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-180534|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-195253|reactome:R-HSA-5676590|reactome:R-HSA-202424|reactome:R-HSA-5678895|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-2871837|reactome:R-HSA-5689880|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-6798695|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-68827|reactome:R-HSA-4641258|reactome:R-HSA-68949|reactome:R-HSA-5358346|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|dip:DIP-27572N refseq:NP_006494.1|refseq:NP_694546.1|dip:DIP-29274N|ensembl:ENSG00000013275(gene)|ensembl:ENSG00000281221(gene)|ensembl:ENST00000157812(transcript)|ensembl:ENST00000629691(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0001824"(blastocyst development)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0030163"(protein catabolic process)|go:"GO:0031597"(cytosolic proteasome complex)|go:"GO:0036402"(proteasome-activating activity)|go:"GO:0045202"(synapse)|go:"GO:0045899"(positive regulation of RNA polymerase II transcription preinitiation complex assembly)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR005937(26S proteasome subunit P45)|interpro:IPR027417|interpro:IPR032501|interpro:IPR035256|interpro:IPR041569|mint:P43686|rcsb pdb:2DVW|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4G|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VGZ|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHJ|rcsb pdb:5VHM|rcsb pdb:5VHN|rcsb pdb:5VHO|rcsb pdb:5VHP|rcsb pdb:5VHQ|rcsb pdb:5VHR|rcsb pdb:5VHS|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|reactome:R-HSA-69601 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:HJaBTx4pIiSDIArqueuNRvhzVvU9606 rogid:ZwHUFX8vJa8IPZi000dHiFtUtlM9606 intact-crc:AAAE3F2EE90EF746|rigid:hduxRD9YTYnGMjMpW+DUy/4clxc false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P51665 uniprotkb:P55036 intact:EBI-357659|uniprotkb:Q6PKI2|uniprotkb:Q96E97|ensembl:ENSP00000219313|uniprotkb:D3DWS9 intact:EBI-359318|uniprotkb:Q5VWC5|uniprotkb:Q9NS92|uniprotkb:D3DV16|ensembl:ENSP00000357879 psi-mi:psmd7_human(display_long)|uniprotkb:PSMD7(gene name)|psi-mi:PSMD7(display_short)|uniprotkb:MOV34L(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN8(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S12(gene name synonym)|uniprotkb:Proteasome subunit p40(gene name synonym)|uniprotkb:Mov34 protein homolog(gene name synonym) psi-mi:psmd4_human(display_long)|uniprotkb:PSMD4(gene name)|psi-mi:PSMD4(display_short)|uniprotkb:MCB1(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S5A(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN10(gene name synonym)|uniprotkb:Multiubiquitin chain-binding protein(gene name synonym)|uniprotkb:Antisecretory factor 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510969|imex:IM-12079-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002802.2|rcsb pdb:5T0J|ensembl:ENSG00000103035(gene)|ensembl:ENST00000219313(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0016020"(membrane)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070122"(isopeptidase activity)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR024969|interpro:IPR033858|interpro:IPR037518|mint:P51665|rcsb pdb:2O95|rcsb pdb:2O96|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VGZ|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHS|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-180534|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-195253|reactome:R-HSA-5676590|reactome:R-HSA-202424|reactome:R-HSA-5678895|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-2871837|reactome:R-HSA-5689880|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-6798695|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-68827|reactome:R-HSA-4641258|reactome:R-HSA-68949|reactome:R-HSA-5358346|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|dip:DIP-27572N refseq:NP_002801.1|dip:DIP-38189N|ensembl:ENSG00000159352(gene)|ensembl:ENST00000368884(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043248"(proteasome assembly)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR036465|mint:P55036|rcsb pdb:1P9C|rcsb pdb:1P9D|rcsb pdb:1UEL|rcsb pdb:1YX4|rcsb pdb:1YX5|rcsb pdb:1YX6|rcsb pdb:2KDE|rcsb pdb:2KDF|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VGZ|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHS|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6MUN|rcsb pdb:6U19|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:HJaBTx4pIiSDIArqueuNRvhzVvU9606 rogid:FTJG3ns3Ag/Y3xP3yEydGxppRcA9606 intact-crc:AAAE3F2EE90EF746|rigid:hduxRD9YTYnGMjMpW+DUy/4clxc false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P51665 uniprotkb:Q13200 intact:EBI-357659|uniprotkb:Q6PKI2|uniprotkb:Q96E97|ensembl:ENSP00000219313|uniprotkb:D3DWS9 intact:EBI-357648|uniprotkb:B4DX07|uniprotkb:B4DXY1|uniprotkb:E7EW34|uniprotkb:E9PCS3|uniprotkb:Q12932|uniprotkb:Q15321|uniprotkb:Q96I12|ensembl:ENSP00000310129|uniprotkb:Q53XQ4 psi-mi:psmd7_human(display_long)|uniprotkb:PSMD7(gene name)|psi-mi:PSMD7(display_short)|uniprotkb:MOV34L(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN8(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S12(gene name synonym)|uniprotkb:Proteasome subunit p40(gene name synonym)|uniprotkb:Mov34 protein homolog(gene name synonym) psi-mi:psmd2_human(display_long)|uniprotkb:PSMD2(gene name)|psi-mi:PSMD2(display_short)|uniprotkb:TRAP2(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN1(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S2(gene name synonym)|uniprotkb:26S proteasome subunit p97(gene name synonym)|uniprotkb:Tumor necrosis factor type 1 receptor-associated protein 2(gene name synonym)|uniprotkb:Protein 55.11(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510969|imex:IM-12079-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002802.2|rcsb pdb:5T0J|ensembl:ENSG00000103035(gene)|ensembl:ENST00000219313(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0016020"(membrane)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070122"(isopeptidase activity)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR024969|interpro:IPR033858|interpro:IPR037518|mint:P51665|rcsb pdb:2O95|rcsb pdb:2O96|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VGZ|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHS|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-180534|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-195253|reactome:R-HSA-5676590|reactome:R-HSA-202424|reactome:R-HSA-5678895|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-2871837|reactome:R-HSA-5689880|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-6798695|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-68827|reactome:R-HSA-4641258|reactome:R-HSA-68949|reactome:R-HSA-5358346|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|dip:DIP-27572N refseq:NP_001265637.1|refseq:NP_001265638.1|refseq:NP_002799.3|ensembl:ENSG00000175166(gene)|ensembl:ENST00000310118(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0034515"(proteasome storage granule)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR002015(Proteasome/cyclosome, regulatory subunit)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040892|interpro:IPR041433|mint:Q13200|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|interpro:IPR016643(26S proteasome regulatory complex, non-ATPase subcomplex, Rpn1 subunit)|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHJ|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|reactome:R-HSA-9010553|rcsb pdb:5VHM|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:5VHN|rcsb pdb:5VHO|rcsb pdb:5VHP|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:5VHQ|rcsb pdb:5VHR|rcsb pdb:5VHS|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|rcsb pdb:6MSB|rcsb pdb:6MSD|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-5668541|dip:DIP-38204N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:HJaBTx4pIiSDIArqueuNRvhzVvU9606 rogid:wujS1i4Gs3gWNinOey4oKsshA+g9606 intact-crc:AAAE3F2EE90EF746|rigid:hduxRD9YTYnGMjMpW+DUy/4clxc false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P51665 uniprotkb:Q16186 intact:EBI-357659|uniprotkb:Q6PKI2|uniprotkb:Q96E97|ensembl:ENSP00000219313|uniprotkb:D3DWS9 intact:EBI-954387|ensembl:ENSP00000253003|ensembl:ENSP00000478877|uniprotkb:A0PKB1|uniprotkb:Q96FJ7|uniprotkb:Q9H1P2 psi-mi:psmd7_human(display_long)|uniprotkb:PSMD7(gene name)|psi-mi:PSMD7(display_short)|uniprotkb:MOV34L(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN8(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S12(gene name synonym)|uniprotkb:Proteasome subunit p40(gene name synonym)|uniprotkb:Mov34 protein homolog(gene name synonym) psi-mi:adrm1_human(display_long)|uniprotkb:Adhesion-regulating molecule 1(gene name synonym)|uniprotkb:110 kDa cell membrane glycoprotein(gene name synonym)|uniprotkb:Rpn13 homolog(gene name synonym)|uniprotkb:Proteasome regulatory particle non-ATPase 13(gene name synonym)|uniprotkb:ADRM1(gene name)|psi-mi:ADRM1(display_short)|uniprotkb:GP110(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510969|imex:IM-12079-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002802.2|rcsb pdb:5T0J|ensembl:ENSG00000103035(gene)|ensembl:ENST00000219313(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0016020"(membrane)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070122"(isopeptidase activity)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR024969|interpro:IPR033858|interpro:IPR037518|mint:P51665|rcsb pdb:2O95|rcsb pdb:2O96|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VGZ|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHS|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-180534|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-195253|reactome:R-HSA-5676590|reactome:R-HSA-202424|reactome:R-HSA-5678895|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-2871837|reactome:R-HSA-5689880|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-6798695|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-68827|reactome:R-HSA-4641258|reactome:R-HSA-68949|reactome:R-HSA-5358346|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|dip:DIP-27572N ensembl:ENSG00000130706(gene)|ensembl:ENST00000253003(transcript)|ensembl:ENST00000491935(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0002020"(protease binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008541"(proteasome regulatory particle, lid subcomplex)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043248"(proteasome assembly)|go:"GO:0061133"(endopeptidase activator activity)|go:"GO:0070628"(proteasome binding)|interpro:IPR006773(Adhesion regulating molecule)|interpro:IPR032368|interpro:IPR038108|interpro:IPR038633|interpro:IPR044867|interpro:IPR044868|mint:Q16186|rcsb pdb:2KQZ|rcsb pdb:2KR0|rcsb pdb:2L5V|rcsb pdb:2MKZ|rcsb pdb:2NBV|rcsb pdb:4UEL|rcsb pdb:4UEM|rcsb pdb:4WLQ|rcsb pdb:4WLR|rcsb pdb:5IRS|rcsb pdb:5V1Y|rcsb pdb:5V1Z|rcsb pdb:5YMY|rcsb pdb:6CO4|rcsb pdb:6OI4|rcsb pdb:6UYJ|reactome:R-HSA-5689603|reactome:R-HSA-5689880|rcsb pdb:6UYI|refseq:NP_008933.2|refseq:NP_783163.1|refseq:NP_001268366.1|refseq:NP_001268367.1|refseq:XP_005260314.1|dip:DIP-42668N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:HJaBTx4pIiSDIArqueuNRvhzVvU9606 rogid:XrSLNnNr5Ojm0HkgcnnPube5Lno9606 intact-crc:AAAE3F2EE90EF746|rigid:hduxRD9YTYnGMjMpW+DUy/4clxc false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P51665 uniprotkb:P17980 intact:EBI-357659|uniprotkb:Q6PKI2|uniprotkb:Q96E97|ensembl:ENSP00000219313|uniprotkb:D3DWS9 intact:EBI-359720|uniprotkb:Q3B757|ensembl:ENSP00000298852|ensembl:ENSP00000481029|uniprotkb:Q3B865|uniprotkb:Q53HU5|uniprotkb:Q6GPG8|uniprotkb:Q6IBS1|uniprotkb:Q96HD3|uniprotkb:B2R8V1 psi-mi:psmd7_human(display_long)|uniprotkb:PSMD7(gene name)|psi-mi:PSMD7(display_short)|uniprotkb:MOV34L(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN8(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S12(gene name synonym)|uniprotkb:Proteasome subunit p40(gene name synonym)|uniprotkb:Mov34 protein homolog(gene name synonym) psi-mi:prs6a_human(display_long)|uniprotkb:PSMC3(gene name)|psi-mi:PSMC3(display_short)|uniprotkb:TBP1(gene name synonym)|uniprotkb:Proteasome 26S subunit ATPase 3(gene name synonym)|uniprotkb:Tat-binding protein 1(gene name synonym)|uniprotkb:Proteasome subunit P50(gene name synonym)|uniprotkb:26S proteasome AAA-ATPase subunit RPT5(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510969|imex:IM-12079-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002802.2|rcsb pdb:5T0J|ensembl:ENSG00000103035(gene)|ensembl:ENST00000219313(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0016020"(membrane)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070122"(isopeptidase activity)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR024969|interpro:IPR033858|interpro:IPR037518|mint:P51665|rcsb pdb:2O95|rcsb pdb:2O96|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VGZ|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHS|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-180534|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-195253|reactome:R-HSA-5676590|reactome:R-HSA-202424|reactome:R-HSA-5678895|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-2871837|reactome:R-HSA-5689880|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-6798695|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-68827|reactome:R-HSA-4641258|reactome:R-HSA-68949|reactome:R-HSA-5358346|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|dip:DIP-27572N refseq:NP_002795.2|ensembl:ENSG00000165916(gene)|ensembl:ENST00000298852(transcript)|ensembl:ENST00000619920(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0000932"(P-body)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0030163"(protein catabolic process)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042802"(identical protein binding)|go:"GO:0043921"(modulation by host of viral transcription)|go:"GO:0045899"(positive regulation of RNA polymerase II transcription preinitiation complex assembly)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR005937(26S proteasome subunit P45)|interpro:IPR027417|interpro:IPR032501|interpro:IPR035254|interpro:IPR041569|mint:P17980|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4G|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VGZ|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHJ|rcsb pdb:5VHM|rcsb pdb:5VHN|rcsb pdb:5VHO|rcsb pdb:5VHP|rcsb pdb:5VHQ|rcsb pdb:5VHR|rcsb pdb:5VHS|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6WJD|rcsb pdb:6WJN|go:"GO:0036402"(proteasome-activating activity)|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-1236978|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|dip:DIP-27555N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:HJaBTx4pIiSDIArqueuNRvhzVvU9606 rogid:CejeauChmqeXNwBYF2cPz7mgMuw9606 intact-crc:AAAE3F2EE90EF746|rigid:hduxRD9YTYnGMjMpW+DUy/4clxc false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P51665 uniprotkb:P62195 intact:EBI-357659|uniprotkb:Q6PKI2|uniprotkb:Q96E97|ensembl:ENSP00000219313|uniprotkb:D3DWS9 intact:EBI-357745|uniprotkb:O35051|uniprotkb:O43208|uniprotkb:P52915|uniprotkb:P47210|uniprotkb:P52916|uniprotkb:A8K763|uniprotkb:A8K3Z3|ensembl:ENSP00000310572 psi-mi:psmd7_human(display_long)|uniprotkb:PSMD7(gene name)|psi-mi:PSMD7(display_short)|uniprotkb:MOV34L(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN8(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S12(gene name synonym)|uniprotkb:Proteasome subunit p40(gene name synonym)|uniprotkb:Mov34 protein homolog(gene name synonym) psi-mi:prs8_human(display_long)|uniprotkb:PSMC5(gene name)|psi-mi:PSMC5(display_short)|uniprotkb:SUG1(gene name synonym)|uniprotkb:Proteasome 26S subunit ATPase 5(gene name synonym)|uniprotkb:Proteasome subunit p45(gene name synonym)|uniprotkb:p45/SUG(gene name synonym)|uniprotkb:Thyroid hormone receptor-interacting protein 1(gene name synonym)|uniprotkb:26S proteasome AAA-ATPase subunit RPT6(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510969|imex:IM-12079-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002802.2|rcsb pdb:5T0J|ensembl:ENSG00000103035(gene)|ensembl:ENST00000219313(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0016020"(membrane)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070122"(isopeptidase activity)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR024969|interpro:IPR033858|interpro:IPR037518|mint:P51665|rcsb pdb:2O95|rcsb pdb:2O96|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VGZ|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHS|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-180534|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-195253|reactome:R-HSA-5676590|reactome:R-HSA-202424|reactome:R-HSA-5678895|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-2871837|reactome:R-HSA-5689880|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-6798695|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-68827|reactome:R-HSA-4641258|reactome:R-HSA-68949|reactome:R-HSA-5358346|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|dip:DIP-27572N refseq:NP_001186092.1|refseq:NP_002796.4|reactome:R-HSA-195253|ensembl:ENSG00000087191(gene)|ensembl:ENST00000310144(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0017025"(TBP-class protein binding)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031531"(thyrotropin-releasing hormone receptor binding)|go:"GO:0031595"(nuclear proteasome complex)|go:"GO:0031597"(cytosolic proteasome complex)|go:"GO:0036402"(proteasome-activating activity)|go:"GO:0043069"(negative regulation of programmed cell death)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045899"(positive regulation of RNA polymerase II transcription preinitiation complex assembly)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0090261"(positive regulation of inclusion body assembly)|go:"GO:0098794"(postsynapse)|go:"GO:0140296"(general transcription initiation factor binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR005937(26S proteasome subunit P45)|interpro:IPR027417|interpro:IPR032501|interpro:IPR041569|mint:P62195|rcsb pdb:2KRK|rcsb pdb:3KW6|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4G|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VGZ|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHJ|rcsb pdb:5VHM|rcsb pdb:5VHN|rcsb pdb:5VHO|rcsb pdb:5VHP|rcsb pdb:5VHQ|rcsb pdb:5VHR|rcsb pdb:5VHS|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|dip:DIP-36645N psi-mi:"MI:0469"(intact) - crc64:29C6410C4A85A7F7 figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:HJaBTx4pIiSDIArqueuNRvhzVvU9606 rogid:zgUTOX/O4m86U/Nf+pnT7u0m0gY9606 intact-crc:AAAE3F2EE90EF746|rigid:hduxRD9YTYnGMjMpW+DUy/4clxc false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P51665 uniprotkb:Q86UP2 intact:EBI-357659|uniprotkb:Q6PKI2|uniprotkb:Q96E97|ensembl:ENSP00000219313|uniprotkb:D3DWS9 intact:EBI-359761|uniprotkb:Q13999|uniprotkb:Q14707|uniprotkb:Q15387|uniprotkb:Q86W57|ensembl:ENSP00000378725|ensembl:ENSP00000432149|uniprotkb:Q17RZ5|uniprotkb:B4DZ88|uniprotkb:Q5GGW3 psi-mi:psmd7_human(display_long)|uniprotkb:PSMD7(gene name)|psi-mi:PSMD7(display_short)|uniprotkb:MOV34L(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN8(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S12(gene name synonym)|uniprotkb:Proteasome subunit p40(gene name synonym)|uniprotkb:Mov34 protein homolog(gene name synonym) psi-mi:ktn1_human(display_long)|uniprotkb:KTN1(gene name)|psi-mi:KTN1(display_short)|uniprotkb:CG1(gene name synonym)|uniprotkb:KIAA0004(gene name synonym)|uniprotkb:Kinesin receptor(gene name synonym)|uniprotkb:CG-1 antigen(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510969|imex:IM-12079-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002802.2|rcsb pdb:5T0J|ensembl:ENSG00000103035(gene)|ensembl:ENST00000219313(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0016020"(membrane)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070122"(isopeptidase activity)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR024969|interpro:IPR033858|interpro:IPR037518|mint:P51665|rcsb pdb:2O95|rcsb pdb:2O96|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VGZ|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHS|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-180534|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-195253|reactome:R-HSA-5676590|reactome:R-HSA-202424|reactome:R-HSA-5678895|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-2871837|reactome:R-HSA-5689880|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-6798695|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-68827|reactome:R-HSA-4641258|reactome:R-HSA-68949|reactome:R-HSA-5358346|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|dip:DIP-27572N refseq:NP_001072989.1|refseq:NP_004977.2|ensembl:ENSG00000126777(gene)|ensembl:ENST00000395314(transcript)|ensembl:ENST00000459737(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019894"(kinesin binding)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0045296"(cadherin binding)|interpro:IPR007794(Ribosome receptor lysine or proline rich)|interpro:IPR024854|mint:Q86UP2|refseq:XP_011535053.1|refseq:XP_011535055.1|reactome:R-HSA-381426|reactome:R-HSA-5625970|reactome:R-HSA-8957275|reactome:R-HSA-8980692|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013408|reactome:R-HSA-9696264|reactome:R-HSA-9696270|refseq:NP_001072990.1|refseq:NP_001257943.1|refseq:XP_006720201.1|refseq:XP_006720202.1|refseq:XP_016876767.1|refseq:XP_016876771.1|refseq:XP_016876772.1|dip:DIP-27585N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:HJaBTx4pIiSDIArqueuNRvhzVvU9606 rogid:paZIiw7G2n1qUQ91xj5zi8x1Oxc9606 intact-crc:AAAE3F2EE90EF746|rigid:hduxRD9YTYnGMjMpW+DUy/4clxc false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P51665 uniprotkb:O00231 intact:EBI-357659|uniprotkb:Q6PKI2|uniprotkb:Q96E97|ensembl:ENSP00000219313|uniprotkb:D3DWS9 intact:EBI-357816|uniprotkb:O00495|uniprotkb:A8K3I7|uniprotkb:E1P663|uniprotkb:Q53FT5|ensembl:ENSP00000261712|ensembl:ENSP00000393185|ensembl:ENSP00000497128 psi-mi:psmd7_human(display_long)|uniprotkb:PSMD7(gene name)|psi-mi:PSMD7(display_short)|uniprotkb:MOV34L(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN8(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S12(gene name synonym)|uniprotkb:Proteasome subunit p40(gene name synonym)|uniprotkb:Mov34 protein homolog(gene name synonym) psi-mi:psd11_human(display_long)|uniprotkb:PSMD11(gene name)|psi-mi:PSMD11(display_short)|uniprotkb:26S proteasome regulatory subunit S9(gene name synonym)|uniprotkb:26S proteasome regulatory subunit p44.5(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN6(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510969|imex:IM-12079-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002802.2|rcsb pdb:5T0J|ensembl:ENSG00000103035(gene)|ensembl:ENST00000219313(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0016020"(membrane)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070122"(isopeptidase activity)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR024969|interpro:IPR033858|interpro:IPR037518|mint:P51665|rcsb pdb:2O95|rcsb pdb:2O96|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VGZ|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHS|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-180534|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-195253|reactome:R-HSA-5676590|reactome:R-HSA-202424|reactome:R-HSA-5678895|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-2871837|reactome:R-HSA-5689880|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-6798695|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-68827|reactome:R-HSA-4641258|reactome:R-HSA-68949|reactome:R-HSA-5358346|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|dip:DIP-27572N refseq:NP_002806.2|refseq:NP_001257411.1|ensembl:ENSG00000108671(gene)|ensembl:ENST00000261712(transcript)|ensembl:ENST00000457654(transcript)|ensembl:ENST00000649012(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008541"(proteasome regulatory particle, lid subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0043248"(proteasome assembly)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR035295|interpro:IPR036390|interpro:IPR040773|interpro:IPR040780|mint:O00231|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5M32|rcsb pdb:5LN3|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VGZ|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHS|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:HJaBTx4pIiSDIArqueuNRvhzVvU9606 rogid:BgQKXK7gMMihacRCI+g/pBnRN309606 intact-crc:AAAE3F2EE90EF746|rigid:hduxRD9YTYnGMjMpW+DUy/4clxc false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P51665 uniprotkb:O00232 intact:EBI-357659|uniprotkb:Q6PKI2|uniprotkb:Q96E97|ensembl:ENSP00000219313|uniprotkb:D3DWS9 intact:EBI-359733|uniprotkb:Q53HA2|uniprotkb:Q6P053|ensembl:ENSP00000348442|uniprotkb:A6NP15 psi-mi:psmd7_human(display_long)|uniprotkb:PSMD7(gene name)|psi-mi:PSMD7(display_short)|uniprotkb:MOV34L(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN8(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S12(gene name synonym)|uniprotkb:Proteasome subunit p40(gene name synonym)|uniprotkb:Mov34 protein homolog(gene name synonym) psi-mi:psd12_human(display_long)|uniprotkb:PSMD12(gene name)|psi-mi:PSMD12(display_short)|uniprotkb:26S proteasome regulatory subunit p55(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN5(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2510969|imex:IM-12079-11 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002802.2|rcsb pdb:5T0J|ensembl:ENSG00000103035(gene)|ensembl:ENST00000219313(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0016020"(membrane)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070122"(isopeptidase activity)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR024969|interpro:IPR033858|interpro:IPR037518|mint:P51665|rcsb pdb:2O95|rcsb pdb:2O96|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VGZ|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHS|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-180534|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-195253|reactome:R-HSA-5676590|reactome:R-HSA-202424|reactome:R-HSA-5678895|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-2871837|reactome:R-HSA-5689880|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-6798695|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-68827|reactome:R-HSA-4641258|reactome:R-HSA-68949|reactome:R-HSA-5358346|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|dip:DIP-27572N refseq:NP_002807.1|refseq:NP_001303270.1|ensembl:ENSG00000197170(gene)|ensembl:ENST00000356126(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0008541"(proteasome regulatory particle, lid subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0031595"(nuclear proteasome complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR035297|interpro:IPR036388|interpro:IPR036390|interpro:IPR040134|interpro:IPR040896|mint:O00232|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VGZ|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHS|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|rcsb pdb:5VFS|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-5687128|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|refseq:NP_777360.1|dip:DIP-27549N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:HJaBTx4pIiSDIArqueuNRvhzVvU9606 rogid:4tzcvfL/EqQRcUpoMtxVU0WC+TU9606 intact-crc:AAAE3F2EE90EF746|rigid:hduxRD9YTYnGMjMpW+DUy/4clxc false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96FJ0 uniprotkb:A2RU54 intact:EBI-745021|uniprotkb:Q5T9N4|uniprotkb:Q5T9N9|uniprotkb:Q7Z420|uniprotkb:Q9P2H4|uniprotkb:B3KPA7|ensembl:ENSP00000360992|ensembl:ENSP00000360994 intact:EBI-2511017|ensembl:ENSP00000341108|uniprotkb:B2RNV5 psi-mi:stalp_human(display_long)|uniprotkb:STAM-binding protein-like 1(gene name synonym)|uniprotkb:STAMBPL1(gene name)|psi-mi:STAMBPL1(display_short)|uniprotkb:KIAA1373(gene name synonym)|uniprotkb:AMSHLP(gene name synonym) psi-mi:hmx2_human(display_long)|uniprotkb:HMX2(gene name)|psi-mi:HMX2(display_short)|uniprotkb:Homeobox protein H6 family member 2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511015|imex:IM-12079-62 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065850.1|ensembl:ENSG00000138134(gene)|ensembl:ENST00000371924(transcript)|ensembl:ENST00000371926(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0046872"(metal ion binding)|go:"GO:0061578"(Lys63-specific deubiquitinase activity)|go:"GO:0070122"(isopeptidase activity)|go:"GO:0070536"(protein K63-linked deubiquitination)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR015063(Region of unknown function DUF1873)|interpro:IPR037518|interpro:IPR044098|rcsb pdb:2ZNR|rcsb pdb:2ZNV|reactome:R-HSA-5689901|refseq:XP_006717991.1|refseq:XP_006717993.1|refseq:XP_011538285.1|refseq:XP_011538287.1|refseq:XP_016871942.1|refseq:XP_016871943.1|refseq:XP_016871944.1|refseq:XP_016871945.1 ensembl:ENSG00000188816(gene)|ensembl:ENST00000339992(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007420"(brain development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0030154"(cell differentiation)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0048026"(positive regulation of mRNA splicing, via spliceosome)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|interpro:IPR020479|refseq:NP_005510.1|refseq:XP_005269800.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:D7HU2TO+Kud2jte+n50H9Sj2Xwk9606 rogid:rMmysvirF2yrqZCZdnEUp5M/0fM9606 intact-crc:3BD44560F778DF82|rigid:Db+uE+Jrg0LB7dwync2ACW2I1qc false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96FJ0 uniprotkb:Q70CQ1 intact:EBI-745021|uniprotkb:Q5T9N4|uniprotkb:Q5T9N9|uniprotkb:Q7Z420|uniprotkb:Q9P2H4|uniprotkb:B3KPA7|ensembl:ENSP00000360992|ensembl:ENSP00000360994 intact:EBI-2511022|ensembl:ENSP00000377797|ensembl:ENSP00000507239|uniprotkb:Q5T3E0|uniprotkb:Q5T3D9|uniprotkb:Q96CK4 psi-mi:stalp_human(display_long)|uniprotkb:STAM-binding protein-like 1(gene name synonym)|uniprotkb:STAMBPL1(gene name)|psi-mi:STAMBPL1(display_short)|uniprotkb:KIAA1373(gene name synonym)|uniprotkb:AMSHLP(gene name synonym) psi-mi:ubp49_human(display_long)|uniprotkb:USP49(gene name)|psi-mi:USP49(display_short)|uniprotkb:Ubiquitin thioesterase 49(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 49(gene name synonym)|uniprotkb:Deubiquitinating enzyme 49(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511015|imex:IM-12079-62 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065850.1|ensembl:ENSG00000138134(gene)|ensembl:ENST00000371924(transcript)|ensembl:ENST00000371926(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0046872"(metal ion binding)|go:"GO:0061578"(Lys63-specific deubiquitinase activity)|go:"GO:0070122"(isopeptidase activity)|go:"GO:0070536"(protein K63-linked deubiquitination)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR015063(Region of unknown function DUF1873)|interpro:IPR037518|interpro:IPR044098|rcsb pdb:2ZNR|rcsb pdb:2ZNV|reactome:R-HSA-5689901|refseq:XP_006717991.1|refseq:XP_006717993.1|refseq:XP_011538285.1|refseq:XP_011538287.1|refseq:XP_016871942.1|refseq:XP_016871943.1|refseq:XP_016871944.1|refseq:XP_016871945.1 refseq:NP_001273483.1|ensembl:ENSG00000164663(gene)|ensembl:ENST00000394253(transcript)|ensembl:ENST00000682992(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035616"(histone H2B conserved C-terminal lysine deubiquitination)|go:"GO:0042393"(histone binding)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|interpro:IPR028889|reactome:R-HSA-5689880|interpro:IPR038765|refseq:NP_061031.2 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:D7HU2TO+Kud2jte+n50H9Sj2Xwk9606 rogid:/u6RWNsUrEKz5MecLGyv4+elO309606 intact-crc:3BD44560F778DF82|rigid:Db+uE+Jrg0LB7dwync2ACW2I1qc false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96FJ0 uniprotkb:B4DPD5 intact:EBI-745021|uniprotkb:Q5T9N4|uniprotkb:Q5T9N9|uniprotkb:Q7Z420|uniprotkb:Q9P2H4|uniprotkb:B3KPA7|ensembl:ENSP00000360992|ensembl:ENSP00000360994 intact:EBI-2510901 psi-mi:stalp_human(display_long)|uniprotkb:STAM-binding protein-like 1(gene name synonym)|uniprotkb:STAMBPL1(gene name)|psi-mi:STAMBPL1(display_short)|uniprotkb:KIAA1373(gene name synonym)|uniprotkb:AMSHLP(gene name synonym) psi-mi:b4dpd5_human(display_long) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511015|imex:IM-12079-62 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065850.1|ensembl:ENSG00000138134(gene)|ensembl:ENST00000371924(transcript)|ensembl:ENST00000371926(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0046872"(metal ion binding)|go:"GO:0061578"(Lys63-specific deubiquitinase activity)|go:"GO:0070122"(isopeptidase activity)|go:"GO:0070536"(protein K63-linked deubiquitination)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR015063(Region of unknown function DUF1873)|interpro:IPR037518|interpro:IPR044098|rcsb pdb:2ZNR|rcsb pdb:2ZNV|reactome:R-HSA-5689901|refseq:XP_006717991.1|refseq:XP_006717993.1|refseq:XP_011538285.1|refseq:XP_011538287.1|refseq:XP_016871942.1|refseq:XP_016871943.1|refseq:XP_016871944.1|refseq:XP_016871945.1 go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0019784"(NEDD8-specific protease activity)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0071108"(protein K48-linked deubiquitination)|interpro:IPR003323(Ovarian tumour, otubain)|interpro:IPR019400|interpro:IPR016615(Ubiquitin thioesterase Otubain)|interpro:IPR038765|interpro:IPR030298|interpro:IPR042467|interpro:IPR042468 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:D7HU2TO+Kud2jte+n50H9Sj2Xwk9606 rogid:QcpTOcBTLNloXGWjcZ3pn/pZ3aI9606 intact-crc:3BD44560F778DF82|rigid:Db+uE+Jrg0LB7dwync2ACW2I1qc false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96FJ0 intact:EBI-2507570 intact:EBI-745021|uniprotkb:Q5T9N4|uniprotkb:Q5T9N9|uniprotkb:Q7Z420|uniprotkb:Q9P2H4|uniprotkb:B3KPA7|ensembl:ENSP00000360992|ensembl:ENSP00000360994 uniparc:UPI0000D62420 psi-mi:stalp_human(display_long)|uniprotkb:STAM-binding protein-like 1(gene name synonym)|uniprotkb:STAMBPL1(gene name)|psi-mi:STAMBPL1(display_short)|uniprotkb:KIAA1373(gene name synonym)|uniprotkb:AMSHLP(gene name synonym) psi-mi:ipi00332656(display_short)|psi-mi:EBI-2507570(display_long) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511015|imex:IM-12079-62 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065850.1|ensembl:ENSG00000138134(gene)|ensembl:ENST00000371924(transcript)|ensembl:ENST00000371926(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0046872"(metal ion binding)|go:"GO:0061578"(Lys63-specific deubiquitinase activity)|go:"GO:0070122"(isopeptidase activity)|go:"GO:0070536"(protein K63-linked deubiquitination)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR015063(Region of unknown function DUF1873)|interpro:IPR037518|interpro:IPR044098|rcsb pdb:2ZNR|rcsb pdb:2ZNV|reactome:R-HSA-5689901|refseq:XP_006717991.1|refseq:XP_006717993.1|refseq:XP_011538285.1|refseq:XP_011538287.1|refseq:XP_016871942.1|refseq:XP_016871943.1|refseq:XP_016871944.1|refseq:XP_016871945.1 - psi-mi:"MI:0469"(intact) - no-uniprot-update:An amino acid sequence which is not represented in UniProt figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:D7HU2TO+Kud2jte+n50H9Sj2Xwk9606 rogid:/FjK8aGPpwE4ocMCbkzPh+XSZrU9606 intact-crc:3BD44560F778DF82|rigid:Db+uE+Jrg0LB7dwync2ACW2I1qc false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96FJ0 uniprotkb:P61088 intact:EBI-745021|uniprotkb:Q5T9N4|uniprotkb:Q5T9N9|uniprotkb:Q7Z420|uniprotkb:Q9P2H4|uniprotkb:B3KPA7|ensembl:ENSP00000360992|ensembl:ENSP00000360994 intact:EBI-1052908|uniprotkb:Q16781|uniprotkb:Q53Y81|ensembl:ENSP00000316176 psi-mi:stalp_human(display_long)|uniprotkb:STAM-binding protein-like 1(gene name synonym)|uniprotkb:STAMBPL1(gene name)|psi-mi:STAMBPL1(display_short)|uniprotkb:KIAA1373(gene name synonym)|uniprotkb:AMSHLP(gene name synonym) psi-mi:ube2n_human(display_long)|uniprotkb:Ubiquitin-protein ligase N(gene name synonym)|uniprotkb:Ubiquitin carrier protein N(gene name synonym)|uniprotkb:Ubc13(gene name synonym)|uniprotkb:Bendless-like ubiquitin-conjugating enzyme(gene name synonym)|uniprotkb:UBE2N(gene name)|psi-mi:UBE2N(display_short)|uniprotkb:BLU(gene name synonym)|uniprotkb:UbcH13(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme N(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511015|imex:IM-12079-62 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065850.1|ensembl:ENSG00000138134(gene)|ensembl:ENST00000371924(transcript)|ensembl:ENST00000371926(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0046872"(metal ion binding)|go:"GO:0061578"(Lys63-specific deubiquitinase activity)|go:"GO:0070122"(isopeptidase activity)|go:"GO:0070536"(protein K63-linked deubiquitination)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR015063(Region of unknown function DUF1873)|interpro:IPR037518|interpro:IPR044098|rcsb pdb:2ZNR|rcsb pdb:2ZNV|reactome:R-HSA-5689901|refseq:XP_006717991.1|refseq:XP_006717993.1|refseq:XP_011538285.1|refseq:XP_011538287.1|refseq:XP_016871942.1|refseq:XP_016871943.1|refseq:XP_016871944.1|refseq:XP_016871945.1 refseq:NP_003339.1|dip:DIP-29829N|ensembl:ENSG00000177889(gene)|ensembl:ENST00000318066(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0031058"(positive regulation of histone modification)|go:"GO:0031372"(UBC13-MMS2 complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033182"(regulation of histone ubiquitination)|go:"GO:0035370"(UBC13-UEV1A complex)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:1J7D|rcsb pdb:2C2V|rcsb pdb:3HCT|rcsb pdb:3HCU|rcsb pdb:3VON|rcsb pdb:3W31|rcsb pdb:4DHI|rcsb pdb:4DHJ|rcsb pdb:4DHZ|rcsb pdb:4IP3|rcsb pdb:4NR3|rcsb pdb:4NRG|rcsb pdb:4NRI|rcsb pdb:4ONL|rcsb pdb:4ONM|rcsb pdb:4ONN|rcsb pdb:4ORH|rcsb pdb:4TKP|rcsb pdb:4WHV|rcsb pdb:5AIT|rcsb pdb:5AIU|rcsb pdb:5EYA|rcsb pdb:5H7S|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5YWR|rcsb pdb:6D6I|rcsb pdb:6JKY|rcsb pdb:6KFP|rcsb pdb:6KG6|rcsb pdb:6KL4|rcsb pdb:6LP2|rcsb pdb:6P5B|rcsb pdb:6S53|reactome:R-HSA-168927|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-5607764|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-5696395|reactome:R-HSA-69473|reactome:R-HSA-8866654|reactome:R-HSA-9020702|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-9646399|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-983168|rcsb pdb:6ULH|rcsb pdb:6UMP|rcsb pdb:6UMS|rcsb pdb:7BBD|rcsb pdb:7BBF|rcsb pdb:7BXG|reactome:R-HSA-1169408|reactome:R-HSA-168638 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:D7HU2TO+Kud2jte+n50H9Sj2Xwk9606 rogid:dqdszHlq5FLPHC6UWX6uvkC6Yz89606 intact-crc:3BD44560F778DF82|rigid:Db+uE+Jrg0LB7dwync2ACW2I1qc false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96FJ0 uniprotkb:P09661 intact:EBI-745021|uniprotkb:Q5T9N4|uniprotkb:Q5T9N9|uniprotkb:Q7Z420|uniprotkb:Q9P2H4|uniprotkb:B3KPA7|ensembl:ENSP00000360992|ensembl:ENSP00000360994 intact:EBI-876439|uniprotkb:Q8TBD2|uniprotkb:B2R5I6|ensembl:ENSP00000254193 psi-mi:stalp_human(display_long)|uniprotkb:STAM-binding protein-like 1(gene name synonym)|uniprotkb:STAMBPL1(gene name)|psi-mi:STAMBPL1(display_short)|uniprotkb:KIAA1373(gene name synonym)|uniprotkb:AMSHLP(gene name synonym) psi-mi:ru2a_human(display_long)|uniprotkb:SNRPA1(gene name)|psi-mi:SNRPA1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511015|imex:IM-12079-62 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065850.1|ensembl:ENSG00000138134(gene)|ensembl:ENST00000371924(transcript)|ensembl:ENST00000371926(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0046872"(metal ion binding)|go:"GO:0061578"(Lys63-specific deubiquitinase activity)|go:"GO:0070122"(isopeptidase activity)|go:"GO:0070536"(protein K63-linked deubiquitination)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR015063(Region of unknown function DUF1873)|interpro:IPR037518|interpro:IPR044098|rcsb pdb:2ZNR|rcsb pdb:2ZNV|reactome:R-HSA-5689901|refseq:XP_006717991.1|refseq:XP_006717993.1|refseq:XP_011538285.1|refseq:XP_011538287.1|refseq:XP_016871942.1|refseq:XP_016871943.1|refseq:XP_016871944.1|refseq:XP_016871945.1 refseq:NP_003081.2|dip:DIP-625N|ensembl:ENSG00000131876(gene)|ensembl:ENST00000254193(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005686"(U2 snRNP)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008380"(RNA splicing)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0030532"(small nuclear ribonucleoprotein complex)|go:"GO:0030620"(U2 snRNA binding)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071007"(U2-type catalytic step 2 spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003603(U2A'/phosphoprotein 32 family A, C-terminal)|interpro:IPR032675|interpro:IPR044640|mint:P09661|rcsb pdb:1A9N|rcsb pdb:5MQF|rcsb pdb:5O9Z|rcsb pdb:5XJC|rcsb pdb:5YZG|rcsb pdb:5Z56|rcsb pdb:5Z57|rcsb pdb:5Z58|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6FF7|rcsb pdb:6ICZ|rcsb pdb:6ID0|rcsb pdb:6ID1|rcsb pdb:6QDV|rcsb pdb:6QX9|rcsb pdb:6Y53|rcsb pdb:6Y5Q|rcsb pdb:7A5P|rcsb pdb:7ABG|rcsb pdb:7ABI|reactome:R-HSA-72163|reactome:R-HSA-8950505 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:D7HU2TO+Kud2jte+n50H9Sj2Xwk9606 rogid:tmZyAPCvMg34GY4kVc6NcnycOeE9606 intact-crc:3BD44560F778DF82|rigid:Db+uE+Jrg0LB7dwync2ACW2I1qc false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96FJ0 uniprotkb:Q14677 intact:EBI-745021|uniprotkb:Q5T9N4|uniprotkb:Q5T9N9|uniprotkb:Q7Z420|uniprotkb:Q9P2H4|uniprotkb:B3KPA7|ensembl:ENSP00000360992|ensembl:ENSP00000360994 intact:EBI-1171113|uniprotkb:Q8NAF1|uniprotkb:Q96E05|uniprotkb:D3DQJ6|uniprotkb:B7Z6F8|intact:EBI-28971708|ensembl:ENSP00000388340 psi-mi:stalp_human(display_long)|uniprotkb:STAM-binding protein-like 1(gene name synonym)|uniprotkb:STAMBPL1(gene name)|psi-mi:STAMBPL1(display_short)|uniprotkb:KIAA1373(gene name synonym)|uniprotkb:AMSHLP(gene name synonym) psi-mi:epn4_human(display_long)|uniprotkb:CLINT1(gene name)|psi-mi:CLINT1(display_short)|uniprotkb:ENTH(gene name synonym)|uniprotkb:EPN4(gene name synonym)|uniprotkb:EPNR(gene name synonym)|uniprotkb:KIAA0171(gene name synonym)|uniprotkb:Epsin-4(gene name synonym)|uniprotkb:Epsin-related protein(gene name synonym)|uniprotkb:Enthoprotin(gene name synonym)|uniprotkb:Clathrin-interacting protein localized in the trans-Golgi region(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511015|imex:IM-12079-62 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065850.1|ensembl:ENSG00000138134(gene)|ensembl:ENST00000371924(transcript)|ensembl:ENST00000371926(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0046872"(metal ion binding)|go:"GO:0061578"(Lys63-specific deubiquitinase activity)|go:"GO:0070122"(isopeptidase activity)|go:"GO:0070536"(protein K63-linked deubiquitination)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR015063(Region of unknown function DUF1873)|interpro:IPR037518|interpro:IPR044098|rcsb pdb:2ZNR|rcsb pdb:2ZNV|reactome:R-HSA-5689901|refseq:XP_006717991.1|refseq:XP_006717993.1|refseq:XP_011538285.1|refseq:XP_011538287.1|refseq:XP_016871942.1|refseq:XP_016871943.1|refseq:XP_016871944.1|refseq:XP_016871945.1 ensembl:ENSP00000388340|ensembl:ENST00000523094|ensembl:ENSP00000429345|ensembl:ENST00000523908|ensembl:ENSP00000429824|ensembl:ENST00000530742|ensembl:ENSP00000433419|refseq:NP_001182484.1|refseq:NP_001182485.1|refseq:NP_055481.1|ensembl:ENSG00000113282(gene)|ensembl:ENST00000411809(transcript)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0016020"(membrane)|go:"GO:0030125"(clathrin vesicle coat)|go:"GO:0030276"(clathrin binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045296"(cadherin binding)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0048471"(perinuclear region of cytoplasm)|interpro:IPR008942(ENTH/VHS)|interpro:IPR013809(Epsin-like, N-terminal)|interpro:IPR030544|mint:Q14677|rcsb pdb:1XGW|rcsb pdb:2QY7|rcsb pdb:2V8S|reactome:R-HSA-432722|dip:DIP-45604N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:D7HU2TO+Kud2jte+n50H9Sj2Xwk9606 rogid:cflzNAWnEQR6zTr4d+hwfy1doC49606 intact-crc:3BD44560F778DF82|rigid:Db+uE+Jrg0LB7dwync2ACW2I1qc false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) intact:EBI-2511089 uniprotkb:Q96EE3 - intact:EBI-922818|uniprotkb:Q8NFU6|uniprotkb:Q96MH3|uniprotkb:Q9C069|uniprotkb:A8K5B1|ensembl:ENSP00000262124 psi-mi:ub6l2_human(display_short)|psi-mi:EBI-2511089(display_long)|uniprotkb:Protein TL13-like(gene name synonym) psi-mi:seh1_human(display_long)|uniprotkb:Nup107-160 subcomplex subunit SEH1(gene name synonym)|uniprotkb:SEH1L(gene name)|psi-mi:SEH1L(display_short)|uniprotkb:SEC13L(gene name synonym)|uniprotkb:SEH1(gene name synonym)|uniprotkb:SEC13-like protein(gene name synonym)|uniprotkb:GATOR complex protein SEH1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511095|imex:IM-12079-63 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) uniprotkb:Q6URH7(uniprot-removed-ac) refseq:NP_001013455.1|refseq:NP_112493.2|ensembl:ENSP00000262124|ensembl:ENST00000399892|ensembl:ENSP00000382779|ensembl:ENSG00000085415(gene)|ensembl:ENST00000262124(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006999"(nuclear pore organization)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0015031"(protein transport)|go:"GO:0031080"(nuclear pore outer ring)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034629"|go:"GO:0035859"(Seh1-associated complex)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051028"(mRNA transport)|go:"GO:0051301"(cell division)|go:"GO:0051315"(attachment of mitotic spindle microtubules to kinetochore)|go:"GO:0061700"(GATOR2 complex)|go:"GO:1904263"(positive regulation of TORC1 signaling)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR020472|interpro:IPR036322|interpro:IPR037363|interpro:IPR037597|mint:Q96EE3|rcsb pdb:5A9Q|reactome:R-HSA-1169408|reactome:R-HSA-141444|reactome:R-HSA-159227|reactome:R-HSA-159230|reactome:R-HSA-159231|reactome:R-HSA-159236|reactome:R-HSA-165054|reactome:R-HSA-168271|reactome:R-HSA-168276|reactome:R-HSA-168325|reactome:R-HSA-168333|reactome:R-HSA-170822|reactome:R-HSA-180746|reactome:R-HSA-180910|reactome:R-HSA-191859|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-3108214|reactome:R-HSA-3232142|reactome:R-HSA-3301854|reactome:R-HSA-3371453|reactome:R-HSA-4085377|reactome:R-HSA-4551638|reactome:R-HSA-4570464|reactome:R-HSA-4615885|reactome:R-HSA-5578749|reactome:R-HSA-5619107|reactome:R-HSA-5663220|reactome:R-HSA-6784531|reactome:R-HSA-68877|reactome:R-HSA-9609690|reactome:R-HSA-9610379|reactome:R-HSA-9615933|reactome:R-HSA-9639288|reactome:R-HSA-9648025 psi-mi:"MI:0469"(intact) no-uniprot-update:|caution:The sequence has been withdrawn from uniprot. - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:zJ25qmOfMY2TebtGq09W44aub809606 rogid:I/aUTa3zTawK6QwtkrUkO8B51W49606 intact-crc:6D2537CD97811969|rigid:AkwUgPrbRrIjwiqfSCayZvb8nEI false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) intact:EBI-2511089 uniprotkb:Q0IIN1 - intact:EBI-2511085 psi-mi:ub6l2_human(display_short)|psi-mi:EBI-2511089(display_long)|uniprotkb:Protein TL13-like(gene name synonym) psi-mi:q0iin1_human(display_long)|uniprotkb:KRT77(gene name)|psi-mi:KRT77(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511095|imex:IM-12079-63 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) uniprotkb:Q6URH7(uniprot-removed-ac) go:"GO:0045095"(keratin filament)|refseq:NP_778253.2|interpro:IPR018039|interpro:IPR003054(Type II keratin)|interpro:IPR032444|interpro:IPR039008 psi-mi:"MI:0469"(intact) no-uniprot-update:|caution:The sequence has been withdrawn from uniprot. - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:zJ25qmOfMY2TebtGq09W44aub809606 rogid:a5ksXnU9Wj7tsqLex3Ti3+kgJyA9606 intact-crc:6D2537CD97811969|rigid:AkwUgPrbRrIjwiqfSCayZvb8nEI false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) intact:EBI-2511089 uniprotkb:P13489 - intact:EBI-1237106|uniprotkb:Q8IZK8|uniprotkb:Q96FD7|uniprotkb:Q9BQ80|uniprotkb:Q9UDK6|ensembl:ENSP00000346402|ensembl:ENSP00000348515|ensembl:ENSP00000380729|ensembl:ENSP00000380738|ensembl:ENSP00000380739|ensembl:ENSP00000416589|ensembl:ENSP00000433999|ensembl:ENSP00000435594|ensembl:ENSP00000478664|ensembl:ENSP00000479004|ensembl:ENSP00000479966|ensembl:ENSP00000480036|ensembl:ENSP00000484572|ensembl:ENSP00000487753|ensembl:ENSP00000487940|ensembl:ENSP00000488734 psi-mi:ub6l2_human(display_short)|psi-mi:EBI-2511089(display_long)|uniprotkb:Protein TL13-like(gene name synonym) psi-mi:rini_human(display_long)|uniprotkb:RNH1(gene name)|psi-mi:RNH1(display_short)|uniprotkb:PRI(gene name synonym)|uniprotkb:RNH(gene name synonym)|uniprotkb:Ribonuclease/angiogenin inhibitor 1(gene name synonym)|uniprotkb:Placental ribonuclease inhibitor(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511095|imex:IM-12079-63 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) uniprotkb:Q6URH7(uniprot-removed-ac) refseq:NP_002930.2|refseq:NP_976317.1|refseq:NP_976318.1|refseq:NP_976319.1|refseq:NP_976320.1|refseq:NP_976321.1|refseq:NP_976322.1|refseq:NP_976323.1|refseq:XP_011518557.1|refseq:XP_011518559.1|refseq:XP_011518560.1|refseq:XP_011518561.1|refseq:XP_011518562.1|refseq:XP_011518563.1|refseq:XP_011518564.1|refseq:XP_011518565.1|refseq:XP_016873595.1|ensembl:ENST00000619599(transcript)|ensembl:ENST00000621211(transcript)|ensembl:ENST00000632527(transcript)|ensembl:ENST00000632954(transcript)|ensembl:ENST00000633287(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006402"(mRNA catabolic process)|go:"GO:0008428"(ribonuclease inhibitor activity)|go:"GO:0032311"(angiogenin-PRI complex)|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR006553(Leucine-rich repeat, cysteine-containing subtype)|interpro:IPR032675|interpro:IPR041302|mint:P13489|rcsb pdb:1A4Y|rcsb pdb:1Z7X|rcsb pdb:2BEX|rcsb pdb:2Q4G|ensembl:ENSG00000023191(gene)|ensembl:ENSG00000276230(gene)|ensembl:ENST00000354420(transcript)|ensembl:ENST00000356187(transcript)|ensembl:ENST00000397604(transcript)|ensembl:ENST00000397614(transcript)|ensembl:ENST00000397615(transcript)|ensembl:ENST00000438658(transcript)|ensembl:ENST00000533410(transcript)|ensembl:ENST00000534797(transcript)|ensembl:ENST00000612988(transcript)|ensembl:ENST00000617351(transcript)|ensembl:ENST00000618184(transcript) psi-mi:"MI:0469"(intact) no-uniprot-update:|caution:The sequence has been withdrawn from uniprot. - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:zJ25qmOfMY2TebtGq09W44aub809606 rogid:1WMWoYulk8Aj8HYhDcqnauddUFk9606 intact-crc:6D2537CD97811969|rigid:AkwUgPrbRrIjwiqfSCayZvb8nEI false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) intact:EBI-2511089 intact:EBI-2511082 - - psi-mi:ub6l2_human(display_short)|psi-mi:EBI-2511089(display_long)|uniprotkb:Protein TL13-like(gene name synonym) psi-mi:ub6l1_human(display_short)|psi-mi:EBI-2511082(display_long)|uniprotkb:Protein TL13(gene name synonym)|uniprotkb:Proto-oncogene TRE-2-like protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511095|imex:IM-12079-63 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) uniprotkb:Q6URH7(uniprot-removed-ac) uniprotkb:O95482(uniprot-removed-ac) psi-mi:"MI:0469"(intact) no-uniprot-update:|caution:The sequence has been withdrawn from uniprot. no-uniprot-update:|caution:The sequence has been withdrawn from uniprot. figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:zJ25qmOfMY2TebtGq09W44aub809606 rogid:CZ4cwn8a37DquGKr049JqKnVaKk9606 intact-crc:6D2537CD97811969|rigid:AkwUgPrbRrIjwiqfSCayZvb8nEI false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) intact:EBI-2511089 uniprotkb:Q9NQC7 - intact:EBI-2117940|uniprotkb:O94934|uniprotkb:Q7L3N6|uniprotkb:Q96EH0|uniprotkb:Q9NZX9|ensembl:ENSP00000308928|ensembl:ENSP00000392025 psi-mi:ub6l2_human(display_short)|psi-mi:EBI-2511089(display_long)|uniprotkb:Protein TL13-like(gene name synonym) psi-mi:cyld_human(display_long)|uniprotkb:Ubiquitin thioesterase CYLD(gene name synonym)|uniprotkb:CYLD(gene name)|psi-mi:CYLD(display_short)|uniprotkb:CYLD1(gene name synonym)|uniprotkb:KIAA0849(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease CYLD(gene name synonym)|uniprotkb:Deubiquitinating enzyme CYLD(gene name synonym)|uniprotkb:HSPC057(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511095|imex:IM-12079-63 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) uniprotkb:Q6URH7(uniprot-removed-ac) refseq:NP_001035814.1|refseq:NP_001035877.1|refseq:NP_056062.1|refseq:XP_016878467.1|refseq:XP_016878469.1|go:"GO:0007049"(cell cycle)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010803"(regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0005874"(microtubule)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032480"(negative regulation of type I interferon production)|go:"GO:0036064"(ciliary basal body)|go:"GO:0045087"(innate immune response)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0060544"(regulation of necroptotic process)|go:"GO:0061578"(Lys63-specific deubiquitinase activity)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0070266"(necroptotic process)|go:"GO:0070423"(nucleotide-binding oligomerization domain containing signaling pathway)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097542"(ciliary tip)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1902017"(regulation of cilium assembly)|go:"GO:1903753"(negative regulation of p38MAPK cascade)|go:"GO:1990108"(protein linear deubiquitination)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001242"(regulation of intrinsic apoptotic signaling pathway)|interpro:IPR000938(Cytoskeleton-associated protein, CAP-Gly)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR036859|interpro:IPR038765|mint:Q9NQC7|rcsb pdb:1IXD|rcsb pdb:1WHL|rcsb pdb:1WHM|rcsb pdb:2VHF|reactome:R-HSA-168638|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5689880|reactome:R-HSA-936440|ensembl:ENSG00000083799(gene)|ensembl:ENST00000311559(transcript)|ensembl:ENST00000427738(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|refseq:XP_005255869.1|refseq:XP_006721212.1|refseq:XP_011521209.1|refseq:XP_016878466.1|refseq:XP_016878468.1 psi-mi:"MI:0469"(intact) no-uniprot-update:|caution:The sequence has been withdrawn from uniprot. - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:zJ25qmOfMY2TebtGq09W44aub809606 rogid:Z01woAwtDVaoNnAthw9tTrBqRao9606 intact-crc:6D2537CD97811969|rigid:AkwUgPrbRrIjwiqfSCayZvb8nEI false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) intact:EBI-2511089 uniprotkb:P45974 - intact:EBI-741277|ensembl:ENSP00000229268|uniprotkb:Q96J22|uniprotkb:D3DUS7|uniprotkb:D3DUS8 psi-mi:ub6l2_human(display_short)|psi-mi:EBI-2511089(display_long)|uniprotkb:Protein TL13-like(gene name synonym) psi-mi:ubp5_human(display_long)|uniprotkb:Ubiquitin-specific-processing protease 5(gene name synonym)|uniprotkb:Deubiquitinating enzyme 5(gene name synonym)|uniprotkb:Isopeptidase T(gene name synonym)|uniprotkb:USP5(gene name)|psi-mi:USP5(display_short)|uniprotkb:ISOT(gene name synonym)|uniprotkb:Ubiquitin thioesterase 5(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511095|imex:IM-12079-63 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) uniprotkb:Q6URH7(uniprot-removed-ac) ensembl:ENSG00000111667(gene)|ensembl:ENST00000229268(transcript)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005764"(lysosome)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0071108"(protein K48-linked deubiquitination)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR009060(UBA-like)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR016652(Ubiquitinyl hydrolase)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|interpro:IPR041432|interpro:IPR041812|mint:P45974|rcsb pdb:2DAG|rcsb pdb:2DAK|rcsb pdb:2G43|rcsb pdb:2G45|rcsb pdb:3IHP|rcsb pdb:6DXH|rcsb pdb:6DXT|rcsb pdb:6NFT|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|rcsb pdb:6P9G|rcsb pdb:7MS5|rcsb pdb:7MS6|rcsb pdb:7MS7|reactome:R-HSA-5689880|reactome:R-HSA-8866652|refseq:NP_001092006.1|refseq:NP_003472.2|dip:DIP-34459N psi-mi:"MI:0469"(intact) no-uniprot-update:|caution:The sequence has been withdrawn from uniprot. - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:zJ25qmOfMY2TebtGq09W44aub809606 rogid:9wmOnaEu1N5ZY3E4UiHp2D9f9j89606 intact-crc:6D2537CD97811969|rigid:AkwUgPrbRrIjwiqfSCayZvb8nEI false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) intact:EBI-2511089 uniprotkb:Q8NFA0 - intact:EBI-2511075|ensembl:ENSP00000300896|intact:EBI-9091112|uniprotkb:Q7Z5T3|uniprotkb:Q9Y591|uniprotkb:Q9BX85 psi-mi:ub6l2_human(display_short)|psi-mi:EBI-2511089(display_long)|uniprotkb:Protein TL13-like(gene name synonym) psi-mi:ubp32_human(display_long)|uniprotkb:USP32(gene name)|psi-mi:USP32(display_short)|uniprotkb:USP10(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 32(gene name synonym)|uniprotkb:Deubiquitinating enzyme 32(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-60(gene name synonym)|uniprotkb:Ubiquitin thioesterase 32(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511095|imex:IM-12079-63 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) uniprotkb:Q6URH7(uniprot-removed-ac) ensembl:ENSG00000170832(gene)|ensembl:ENST00000300896(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016020"(membrane)|go:"GO:0016579"(protein deubiquitination)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR018200|interpro:IPR018247|interpro:IPR028889|interpro:IPR035927|interpro:IPR038765|interpro:IPR011992(EF-Hand type)|refseq:NP_115971.2|dip:DIP-53613N psi-mi:"MI:0469"(intact) no-uniprot-update:|caution:The sequence has been withdrawn from uniprot. - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:zJ25qmOfMY2TebtGq09W44aub809606 rogid:DOnkgvUHy/ldOL9DCSP8PJppAY09606 intact-crc:6D2537CD97811969|rigid:AkwUgPrbRrIjwiqfSCayZvb8nEI false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) intact:EBI-2511089 uniprotkb:Q96DC9 - intact:EBI-746259|uniprotkb:Q9H6T1|uniprotkb:Q6IA10|ensembl:ENSP00000203664|ensembl:ENSP00000478628 psi-mi:ub6l2_human(display_short)|psi-mi:EBI-2511089(display_long)|uniprotkb:Protein TL13-like(gene name synonym) psi-mi:otub2_human(display_long)|uniprotkb:Otubain-2(gene name synonym)|uniprotkb:OTU domain-containing ubiquitin aldehyde-binding protein 2(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease OTUB2(gene name synonym)|uniprotkb:Deubiquitinating enzyme OTUB2(gene name synonym)|uniprotkb:OTUB2(gene name)|psi-mi:OTUB2(display_short)|uniprotkb:C14orf137(gene name synonym)|uniprotkb:OTB2(gene name synonym)|uniprotkb:OTU2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511095|imex:IM-12079-63 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) uniprotkb:Q6URH7(uniprot-removed-ac) refseq:NP_075601.1|go:"GO:1901315"(negative regulation of histone H2A K63-linked ubiquitination)|go:"GO:2000780"(negative regulation of double-strand break repair)|interpro:IPR003323(Ovarian tumour, otubain)|interpro:IPR016615(Ubiquitin thioesterase Otubain)|interpro:IPR019400|interpro:IPR030299|interpro:IPR038765|interpro:IPR042467|interpro:IPR042468|rcsb pdb:1TFF|rcsb pdb:4FJV|rcsb pdb:5QIO|rcsb pdb:5QIP|rcsb pdb:5QIQ|rcsb pdb:5QIR|rcsb pdb:5QIS|rcsb pdb:5QIT|rcsb pdb:5QIU|rcsb pdb:5QIV|rcsb pdb:5QIW|rcsb pdb:5QIX|rcsb pdb:5QIY|rcsb pdb:5QIZ|reactome:R-HSA-5689896|ensembl:ENSG00000089723(gene)|ensembl:ENSG00000277276(gene)|ensembl:ENST00000203664(transcript)|ensembl:ENST00000617748(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035871"(protein K11-linked deubiquitination)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination) psi-mi:"MI:0469"(intact) no-uniprot-update:|caution:The sequence has been withdrawn from uniprot. - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:zJ25qmOfMY2TebtGq09W44aub809606 rogid:VRoMLaGboqq1kdgtxKBy76srvi09606 intact-crc:6D2537CD97811969|rigid:AkwUgPrbRrIjwiqfSCayZvb8nEI false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) intact:EBI-2511089 uniprotkb:Q08188 - intact:EBI-1050019|uniprotkb:A8K5N6|uniprotkb:Q32MM0|uniprotkb:O95933|uniprotkb:Q32ML9|uniprotkb:B2RCR6|uniprotkb:D3DVX1|ensembl:ENSP00000370867 psi-mi:ub6l2_human(display_short)|psi-mi:EBI-2511089(display_long)|uniprotkb:Protein TL13-like(gene name synonym) psi-mi:tgm3_human(display_long)|uniprotkb:Transglutaminase-3(gene name synonym)|uniprotkb:TGM3(gene name)|psi-mi:TGM3(display_short)|uniprotkb:Transglutaminase E(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511095|imex:IM-12079-63 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) uniprotkb:Q6URH7(uniprot-removed-ac) refseq:NP_003236.3|ensembl:ENSG00000125780(gene)|ensembl:ENST00000381458(transcript)|go:"GO:0003810"(protein-glutamine gamma-glutamyltransferase activity)|go:"GO:0003824"(catalytic activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0016746"(acyltransferase activity)|go:"GO:0018149"(peptide cross-linking)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031424"(keratinization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043163"(cell envelope organization)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001102(Transglutaminase, N-terminal)|interpro:IPR002931(Transglutaminase-like)|interpro:IPR008958(Transglutaminase, C-terminal)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR013808(Transglutaminase, conserved site)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR023608|interpro:IPR036238|interpro:IPR036985|interpro:IPR038765|mint:Q08188|rcsb pdb:1L9M|rcsb pdb:1L9N|rcsb pdb:1NUD|rcsb pdb:1NUF|rcsb pdb:1NUG psi-mi:"MI:0469"(intact) no-uniprot-update:|caution:The sequence has been withdrawn from uniprot. - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:zJ25qmOfMY2TebtGq09W44aub809606 rogid:5UuVUvhYOaQcLJQO2myrilPgFFw9606 intact-crc:6D2537CD97811969|rigid:AkwUgPrbRrIjwiqfSCayZvb8nEI false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O95630 uniprotkb:Q9Y3E7 intact:EBI-396676|uniprotkb:Q3MJE7|uniprotkb:D6W5H7|uniprotkb:B5M0B6|ensembl:ENSP00000344742|ensembl:ENSP00000377633|ensembl:ENSP00000377636|ensembl:ENSP00000386548|ensembl:ENSP00000506833|ensembl:ENSP00000506845|ensembl:ENSP00000506865|ensembl:ENSP00000506958|ensembl:ENSP00000507014|ensembl:ENSP00000507054|ensembl:ENSP00000507081|ensembl:ENSP00000507092|ensembl:ENSP00000507639|ensembl:ENSP00000507658|ensembl:ENSP00000507864 intact:EBI-2118119|uniprotkb:B4DG34|uniprotkb:B8ZZM0|uniprotkb:Q3ZTS9|uniprotkb:Q53S71|uniprotkb:Q53SU5|uniprotkb:Q9NZ51|uniprotkb:A8K3W0|uniprotkb:B8ZZX5|intact:EBI-2563192|ensembl:ENSP00000263856 psi-mi:stabp_human(display_long)|uniprotkb:AMSH(gene name synonym)|uniprotkb:STAMBP(gene name)|psi-mi:STAMBP(display_short)|uniprotkb:Associated molecule with the SH3 domain of STAM(gene name synonym)|uniprotkb:Endosome-associated ubiquitin isopeptidase(gene name synonym) psi-mi:chmp3_human(display_long)|uniprotkb:CHMP3(gene name)|psi-mi:CHMP3(display_short)|uniprotkb:CGI149(gene name synonym)|uniprotkb:Chromatin-modifying protein 3(gene name synonym)|uniprotkb:NEDF(gene name synonym)|uniprotkb:Neuroendocrine differentiation factor(gene name synonym)|uniprotkb:VPS24(gene name synonym)|uniprotkb:Vacuolar protein sorting-associated protein 24(gene name synonym)|uniprotkb:CGI-149(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511053|imex:IM-12079-12 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006454.1|refseq:NP_964010.1|refseq:NP_998787.1|refseq:XP_005264145.1|refseq:XP_011530785.1|refseq:XP_016858664.1|go:"GO:0016020"(membrane)|go:"GO:0014067"(negative regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032154"(cleavage furrow)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0046872"(metal ion binding)|go:"GO:0061578"(Lys63-specific deubiquitinase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070122"(isopeptidase activity)|go:"GO:0070536"(protein K63-linked deubiquitination)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR015063(Region of unknown function DUF1873)|interpro:IPR037518|interpro:IPR044098|mint:O95630|rcsb pdb:2XZE|rcsb pdb:3RZU|rcsb pdb:3RZV|rcsb pdb:5IXF|reactome:R-HSA-5689901|ensembl:ENSG00000124356(gene)|ensembl:ENST00000339566(transcript)|ensembl:ENST00000394070(transcript)|ensembl:ENST00000394073(transcript)|ensembl:ENST00000409707(transcript)|ensembl:ENST00000682351(transcript)|ensembl:ENST00000682379(transcript)|ensembl:ENST00000682558(transcript)|ensembl:ENST00000682847(transcript)|ensembl:ENST00000683036(transcript)|ensembl:ENST00000683317(transcript)|ensembl:ENST00000683518(transcript)|ensembl:ENST00000683818(transcript)|ensembl:ENST00000684095(transcript)|ensembl:ENST00000684312(transcript)|ensembl:ENST00000684585(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|dip:DIP-33062N refseq:NP_001005753.1|refseq:NP_001180446.1|refseq:NP_057163.1|refseq:NP_001185883.1|dip:DIP-48532N|ensembl:ENSG00000115561(gene)|ensembl:ENST00000263856(transcript)|go:"GO:0000815"(ESCRT III complex)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0010824"(regulation of centrosome duplication)|go:"GO:0015031"(protein transport)|go:"GO:0016236"(macroautophagy)|go:"GO:0030496"(midbody)|go:"GO:0031210"(phosphatidylcholine binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0032509"(endosome transport via multivesicular body sorting pathway)|go:"GO:0036258"(multivesicular body assembly)|go:"GO:0039702"(viral budding via host ESCRT complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0045324"(late endosome to vacuole transport)|go:"GO:0046761"(viral budding from plasma membrane)|go:"GO:0051036"(regulation of endosome size)|go:"GO:0051258"(protein polymerization)|go:"GO:0061763"(multivesicular body-lysosome fusion)|go:"GO:0061952"(midbody abscission)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071985"(multivesicular body sorting pathway)|go:"GO:0097352"(autophagosome maturation)|go:"GO:1902187"|go:"GO:1902188"(obsolete positive regulation of viral release from host cell)|go:"GO:1990381"(ubiquitin-specific protease binding)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|interpro:IPR005024(Snf7)|mint:Q9Y3E7|rcsb pdb:2GD5|rcsb pdb:2XZE|rcsb pdb:3FRT|rcsb pdb:3FRV|reactome:R-HSA-162588|reactome:R-HSA-1632852|reactome:R-HSA-5620971|reactome:R-HSA-917729|reactome:R-HSA-9610379|reactome:R-HSA-9615710|reactome:R-HSA-9668328|reactome:R-HSA-9679504|reactome:R-HSA-9694676 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:JUvszgPz9rog/OEpmABJ295BaLw9606 rogid:mQEFHnkxyS1ZOfqKqGg9KtOjJFQ9606 intact-crc:F868603FE2BF80AC|rigid:sEnXxGIGbcDKnyGI0/x14wY/lnk false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O95630 uniprotkb:O00443 intact:EBI-396676|uniprotkb:Q3MJE7|uniprotkb:D6W5H7|uniprotkb:B5M0B6|ensembl:ENSP00000344742|ensembl:ENSP00000377633|ensembl:ENSP00000377636|ensembl:ENSP00000386548|ensembl:ENSP00000506833|ensembl:ENSP00000506845|ensembl:ENSP00000506865|ensembl:ENSP00000506958|ensembl:ENSP00000507014|ensembl:ENSP00000507054|ensembl:ENSP00000507081|ensembl:ENSP00000507092|ensembl:ENSP00000507639|ensembl:ENSP00000507658|ensembl:ENSP00000507864 intact:EBI-641094|ensembl:ENSP00000265970|uniprotkb:Q14CQ9|uniprotkb:B4E2G4|uniprotkb:B0LPH2 psi-mi:stabp_human(display_long)|uniprotkb:AMSH(gene name synonym)|uniprotkb:STAMBP(gene name)|psi-mi:STAMBP(display_short)|uniprotkb:Associated molecule with the SH3 domain of STAM(gene name synonym)|uniprotkb:Endosome-associated ubiquitin isopeptidase(gene name synonym) psi-mi:p3c2a_human(display_long)|uniprotkb:Phosphoinositide 3-kinase-C2-alpha(gene name synonym)|uniprotkb:PIK3C2A(gene name)|psi-mi:PIK3C2A(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511053|imex:IM-12079-12 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006454.1|refseq:NP_964010.1|refseq:NP_998787.1|refseq:XP_005264145.1|refseq:XP_011530785.1|refseq:XP_016858664.1|go:"GO:0016020"(membrane)|go:"GO:0014067"(negative regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032154"(cleavage furrow)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0046872"(metal ion binding)|go:"GO:0061578"(Lys63-specific deubiquitinase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070122"(isopeptidase activity)|go:"GO:0070536"(protein K63-linked deubiquitination)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR015063(Region of unknown function DUF1873)|interpro:IPR037518|interpro:IPR044098|mint:O95630|rcsb pdb:2XZE|rcsb pdb:3RZU|rcsb pdb:3RZV|rcsb pdb:5IXF|reactome:R-HSA-5689901|ensembl:ENSG00000124356(gene)|ensembl:ENST00000339566(transcript)|ensembl:ENST00000394070(transcript)|ensembl:ENST00000394073(transcript)|ensembl:ENST00000409707(transcript)|ensembl:ENST00000682351(transcript)|ensembl:ENST00000682379(transcript)|ensembl:ENST00000682558(transcript)|ensembl:ENST00000682847(transcript)|ensembl:ENST00000683036(transcript)|ensembl:ENST00000683317(transcript)|ensembl:ENST00000683518(transcript)|ensembl:ENST00000683818(transcript)|ensembl:ENST00000684095(transcript)|ensembl:ENST00000684312(transcript)|ensembl:ENST00000684585(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|dip:DIP-33062N ensembl:ENSG00000011405(gene)|ensembl:ENST00000265970(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0006897"(endocytosis)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0014829"(vascular associated smooth muscle contraction)|go:"GO:0016020"(membrane)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0016477"(cell migration)|go:"GO:0006887"(exocytosis)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030276"(clathrin binding)|go:"GO:0031982"(vesicle)|go:"GO:0035004"(phosphatidylinositol 3-kinase activity)|go:"GO:0035005"(1-phosphatidylinositol-4-phosphate 3-kinase activity)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0036092"(phosphatidylinositol-3-phosphate biosynthetic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|refseq:NP_001308307.1|refseq:XP_016873413.1|refseq:NP_002636.2|go:"GO:0046934"(phosphatidylinositol-4,5-bisphosphate 3-kinase activity)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0052742"(phosphatidylinositol kinase activity)|go:"GO:0052812"(phosphatidylinositol-3,4-bisphosphate 5-kinase activity)|go:"GO:0061024"(membrane organization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090050"(positive regulation of cell migration involved in sprouting angiogenesis)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000341(Phosphoinositide 3-kinase, ras-binding)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR001263(Phosphoinositide 3-kinase accessory region PIK)|interpro:IPR001683(Phox-like)|interpro:IPR002420(Phosphoinositide 3-kinase, C2)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015433(Phosphatidylinositol Kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR029071|interpro:IPR035892|interpro:IPR036871|interpro:IPR036940|interpro:IPR037705|interpro:IPR042133|interpro:IPR042236|rcsb pdb:2AR5|rcsb pdb:2IWL|rcsb pdb:2REA|rcsb pdb:2RED|rcsb pdb:6BTY|rcsb pdb:6BTZ|rcsb pdb:6BU0|rcsb pdb:6BUB|reactome:R-HSA-1660499|reactome:R-HSA-1660514|reactome:R-HSA-1660516|reactome:R-HSA-1660517|reactome:R-HSA-432722|reactome:R-HSA-8856828|dip:DIP-33727N|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process) psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:JUvszgPz9rog/OEpmABJ295BaLw9606 rogid:etm4OwWiGBZtmarHi94o8yW9js89606 intact-crc:F868603FE2BF80AC|rigid:sEnXxGIGbcDKnyGI0/x14wY/lnk false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O95630 uniprotkb:P02771 intact:EBI-396676|uniprotkb:Q3MJE7|uniprotkb:D6W5H7|uniprotkb:B5M0B6|ensembl:ENSP00000344742|ensembl:ENSP00000377633|ensembl:ENSP00000377636|ensembl:ENSP00000386548|ensembl:ENSP00000506833|ensembl:ENSP00000506845|ensembl:ENSP00000506865|ensembl:ENSP00000506958|ensembl:ENSP00000507014|ensembl:ENSP00000507054|ensembl:ENSP00000507081|ensembl:ENSP00000507092|ensembl:ENSP00000507639|ensembl:ENSP00000507658|ensembl:ENSP00000507864 intact:EBI-722498|uniprotkb:B2RBU3|ensembl:ENSP00000379138 psi-mi:stabp_human(display_long)|uniprotkb:AMSH(gene name synonym)|uniprotkb:STAMBP(gene name)|psi-mi:STAMBP(display_short)|uniprotkb:Associated molecule with the SH3 domain of STAM(gene name synonym)|uniprotkb:Endosome-associated ubiquitin isopeptidase(gene name synonym) psi-mi:feta_human(display_long)|uniprotkb:Alpha-1-fetoprotein(gene name synonym)|uniprotkb:Alpha-fetoglobulin(gene name synonym)|uniprotkb:AFP(gene name)|psi-mi:AFP(display_short)|uniprotkb:HPAFP(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511053|imex:IM-12079-12 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006454.1|refseq:NP_964010.1|refseq:NP_998787.1|refseq:XP_005264145.1|refseq:XP_011530785.1|refseq:XP_016858664.1|go:"GO:0016020"(membrane)|go:"GO:0014067"(negative regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032154"(cleavage furrow)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0046872"(metal ion binding)|go:"GO:0061578"(Lys63-specific deubiquitinase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070122"(isopeptidase activity)|go:"GO:0070536"(protein K63-linked deubiquitination)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR015063(Region of unknown function DUF1873)|interpro:IPR037518|interpro:IPR044098|mint:O95630|rcsb pdb:2XZE|rcsb pdb:3RZU|rcsb pdb:3RZV|rcsb pdb:5IXF|reactome:R-HSA-5689901|ensembl:ENSG00000124356(gene)|ensembl:ENST00000339566(transcript)|ensembl:ENST00000394070(transcript)|ensembl:ENST00000394073(transcript)|ensembl:ENST00000409707(transcript)|ensembl:ENST00000682351(transcript)|ensembl:ENST00000682379(transcript)|ensembl:ENST00000682558(transcript)|ensembl:ENST00000682847(transcript)|ensembl:ENST00000683036(transcript)|ensembl:ENST00000683317(transcript)|ensembl:ENST00000683518(transcript)|ensembl:ENST00000683818(transcript)|ensembl:ENST00000684095(transcript)|ensembl:ENST00000684312(transcript)|ensembl:ENST00000684585(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|dip:DIP-33062N refseq:NP_001125.1|ensembl:ENSG00000081051(gene)|ensembl:ENST00000395792(transcript)|go:"GO:0001542"(ovulation from ovarian follicle)|go:"GO:0005504"(fatty acid binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0008270"(zinc ion binding)|go:"GO:0042448"(progesterone metabolic process)|go:"GO:0060395"(SMAD protein signal transduction)|interpro:IPR000264(Serum albumin)|interpro:IPR014760(Serum albumin, N-terminal)|interpro:IPR020857|interpro:IPR020858|interpro:IPR021177|rcsb pdb:3MRK|reactome:R-HSA-381426|reactome:R-HSA-8957275 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:JUvszgPz9rog/OEpmABJ295BaLw9606 rogid:9T14bL8ILokZ3DSmg63Q8ooxBCg9606 intact-crc:F868603FE2BF80AC|rigid:sEnXxGIGbcDKnyGI0/x14wY/lnk false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O95630 uniprotkb:Q14677 intact:EBI-396676|uniprotkb:Q3MJE7|uniprotkb:D6W5H7|uniprotkb:B5M0B6|ensembl:ENSP00000344742|ensembl:ENSP00000377633|ensembl:ENSP00000377636|ensembl:ENSP00000386548|ensembl:ENSP00000506833|ensembl:ENSP00000506845|ensembl:ENSP00000506865|ensembl:ENSP00000506958|ensembl:ENSP00000507014|ensembl:ENSP00000507054|ensembl:ENSP00000507081|ensembl:ENSP00000507092|ensembl:ENSP00000507639|ensembl:ENSP00000507658|ensembl:ENSP00000507864 intact:EBI-1171113|uniprotkb:Q8NAF1|uniprotkb:Q96E05|uniprotkb:D3DQJ6|uniprotkb:B7Z6F8|intact:EBI-28971708|ensembl:ENSP00000388340 psi-mi:stabp_human(display_long)|uniprotkb:AMSH(gene name synonym)|uniprotkb:STAMBP(gene name)|psi-mi:STAMBP(display_short)|uniprotkb:Associated molecule with the SH3 domain of STAM(gene name synonym)|uniprotkb:Endosome-associated ubiquitin isopeptidase(gene name synonym) psi-mi:epn4_human(display_long)|uniprotkb:CLINT1(gene name)|psi-mi:CLINT1(display_short)|uniprotkb:ENTH(gene name synonym)|uniprotkb:EPN4(gene name synonym)|uniprotkb:EPNR(gene name synonym)|uniprotkb:KIAA0171(gene name synonym)|uniprotkb:Epsin-4(gene name synonym)|uniprotkb:Epsin-related protein(gene name synonym)|uniprotkb:Enthoprotin(gene name synonym)|uniprotkb:Clathrin-interacting protein localized in the trans-Golgi region(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511053|imex:IM-12079-12 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006454.1|refseq:NP_964010.1|refseq:NP_998787.1|refseq:XP_005264145.1|refseq:XP_011530785.1|refseq:XP_016858664.1|go:"GO:0016020"(membrane)|go:"GO:0014067"(negative regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032154"(cleavage furrow)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0046872"(metal ion binding)|go:"GO:0061578"(Lys63-specific deubiquitinase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070122"(isopeptidase activity)|go:"GO:0070536"(protein K63-linked deubiquitination)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR015063(Region of unknown function DUF1873)|interpro:IPR037518|interpro:IPR044098|mint:O95630|rcsb pdb:2XZE|rcsb pdb:3RZU|rcsb pdb:3RZV|rcsb pdb:5IXF|reactome:R-HSA-5689901|ensembl:ENSG00000124356(gene)|ensembl:ENST00000339566(transcript)|ensembl:ENST00000394070(transcript)|ensembl:ENST00000394073(transcript)|ensembl:ENST00000409707(transcript)|ensembl:ENST00000682351(transcript)|ensembl:ENST00000682379(transcript)|ensembl:ENST00000682558(transcript)|ensembl:ENST00000682847(transcript)|ensembl:ENST00000683036(transcript)|ensembl:ENST00000683317(transcript)|ensembl:ENST00000683518(transcript)|ensembl:ENST00000683818(transcript)|ensembl:ENST00000684095(transcript)|ensembl:ENST00000684312(transcript)|ensembl:ENST00000684585(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|dip:DIP-33062N ensembl:ENSP00000388340|ensembl:ENST00000523094|ensembl:ENSP00000429345|ensembl:ENST00000523908|ensembl:ENSP00000429824|ensembl:ENST00000530742|ensembl:ENSP00000433419|refseq:NP_001182484.1|refseq:NP_001182485.1|refseq:NP_055481.1|ensembl:ENSG00000113282(gene)|ensembl:ENST00000411809(transcript)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0016020"(membrane)|go:"GO:0030125"(clathrin vesicle coat)|go:"GO:0030276"(clathrin binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045296"(cadherin binding)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0048471"(perinuclear region of cytoplasm)|interpro:IPR008942(ENTH/VHS)|interpro:IPR013809(Epsin-like, N-terminal)|interpro:IPR030544|mint:Q14677|rcsb pdb:1XGW|rcsb pdb:2QY7|rcsb pdb:2V8S|reactome:R-HSA-432722|dip:DIP-45604N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:JUvszgPz9rog/OEpmABJ295BaLw9606 rogid:cflzNAWnEQR6zTr4d+hwfy1doC49606 intact-crc:F868603FE2BF80AC|rigid:sEnXxGIGbcDKnyGI0/x14wY/lnk false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O95630 uniprotkb:P09496 intact:EBI-396676|uniprotkb:Q3MJE7|uniprotkb:D6W5H7|uniprotkb:B5M0B6|ensembl:ENSP00000344742|ensembl:ENSP00000377633|ensembl:ENSP00000377636|ensembl:ENSP00000386548|ensembl:ENSP00000506833|ensembl:ENSP00000506845|ensembl:ENSP00000506865|ensembl:ENSP00000506958|ensembl:ENSP00000507014|ensembl:ENSP00000507054|ensembl:ENSP00000507081|ensembl:ENSP00000507092|ensembl:ENSP00000507639|ensembl:ENSP00000507658|ensembl:ENSP00000507864 intact:EBI-1171169|uniprotkb:Q2XPN5|uniprotkb:Q53XZ1|uniprotkb:A8K4W3|uniprotkb:B4DIN1|uniprotkb:F5H6N3|ensembl:ENSP00000242285|ensembl:ENSP00000401019 psi-mi:stabp_human(display_long)|uniprotkb:AMSH(gene name synonym)|uniprotkb:STAMBP(gene name)|psi-mi:STAMBP(display_short)|uniprotkb:Associated molecule with the SH3 domain of STAM(gene name synonym)|uniprotkb:Endosome-associated ubiquitin isopeptidase(gene name synonym) psi-mi:clca_human(display_long)|uniprotkb:CLTA(gene name)|psi-mi:CLTA(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511053|imex:IM-12079-12 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006454.1|refseq:NP_964010.1|refseq:NP_998787.1|refseq:XP_005264145.1|refseq:XP_011530785.1|refseq:XP_016858664.1|go:"GO:0016020"(membrane)|go:"GO:0014067"(negative regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032154"(cleavage furrow)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0046872"(metal ion binding)|go:"GO:0061578"(Lys63-specific deubiquitinase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070122"(isopeptidase activity)|go:"GO:0070536"(protein K63-linked deubiquitination)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR015063(Region of unknown function DUF1873)|interpro:IPR037518|interpro:IPR044098|mint:O95630|rcsb pdb:2XZE|rcsb pdb:3RZU|rcsb pdb:3RZV|rcsb pdb:5IXF|reactome:R-HSA-5689901|ensembl:ENSG00000124356(gene)|ensembl:ENST00000339566(transcript)|ensembl:ENST00000394070(transcript)|ensembl:ENST00000394073(transcript)|ensembl:ENST00000409707(transcript)|ensembl:ENST00000682351(transcript)|ensembl:ENST00000682379(transcript)|ensembl:ENST00000682558(transcript)|ensembl:ENST00000682847(transcript)|ensembl:ENST00000683036(transcript)|ensembl:ENST00000683317(transcript)|ensembl:ENST00000683518(transcript)|ensembl:ENST00000683818(transcript)|ensembl:ENST00000684095(transcript)|ensembl:ENST00000684312(transcript)|ensembl:ENST00000684585(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|dip:DIP-33062N refseq:NP_001070145.1|refseq:NP_001824.1|refseq:NP_009027.1|refseq:NP_001171689.1|refseq:NP_001171691.1|ensembl:ENSG00000122705(gene)|ensembl:ENST00000242285(transcript)|ensembl:ENST00000433436(transcript)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007049"(cell cycle)|go:"GO:0016020"(membrane)|go:"GO:0030118"(clathrin coat)|go:"GO:0030125"(clathrin vesicle coat)|go:"GO:0030130"(clathrin coat of trans-Golgi network vesicle)|go:"GO:0030132"(clathrin coat of coated pit)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032050"(clathrin heavy chain binding)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0036020"(endolysosome membrane)|go:"GO:0042277"(peptide binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0051020"(GTPase binding)|go:"GO:0051301"(cell division)|go:"GO:0071439"(clathrin complex)|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0098835"(presynaptic endocytic zone membrane)|go:"GO:0099631"(postsynaptic endocytic zone cytoplasmic component)|interpro:IPR000996(Clathrin light chain)|mint:P09496|rcsb pdb:6E5N|reactome:R-HSA-168275|reactome:R-HSA-177504|reactome:R-HSA-190873|reactome:R-HSA-196025|reactome:R-HSA-2132295|reactome:R-HSA-432720|reactome:R-HSA-432722|reactome:R-HSA-437239|reactome:R-HSA-5099900|reactome:R-HSA-5140745|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8866427|reactome:R-HSA-8964038|reactome:R-HSA-3928665 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:JUvszgPz9rog/OEpmABJ295BaLw9606 rogid:RCF3QpQKI1yZFOTAyzhvRkR9ek49606 intact-crc:F868603FE2BF80AC|rigid:sEnXxGIGbcDKnyGI0/x14wY/lnk false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O95630 uniprotkb:P62993 intact:EBI-396676|uniprotkb:Q3MJE7|uniprotkb:D6W5H7|uniprotkb:B5M0B6|ensembl:ENSP00000344742|ensembl:ENSP00000377633|ensembl:ENSP00000377636|ensembl:ENSP00000386548|ensembl:ENSP00000506833|ensembl:ENSP00000506845|ensembl:ENSP00000506865|ensembl:ENSP00000506958|ensembl:ENSP00000507014|ensembl:ENSP00000507054|ensembl:ENSP00000507081|ensembl:ENSP00000507092|ensembl:ENSP00000507639|ensembl:ENSP00000507658|ensembl:ENSP00000507864 intact:EBI-401755|ensembl:ENSP00000339007|uniprotkb:P29354|uniprotkb:Q14450|uniprotkb:Q63057|uniprotkb:Q63059|ensembl:ENSP00000376345|ensembl:ENSP00000376347|ensembl:ENSP00000496913 psi-mi:stabp_human(display_long)|uniprotkb:AMSH(gene name synonym)|uniprotkb:STAMBP(gene name)|psi-mi:STAMBP(display_short)|uniprotkb:Associated molecule with the SH3 domain of STAM(gene name synonym)|uniprotkb:Endosome-associated ubiquitin isopeptidase(gene name synonym) psi-mi:grb2_human(display_long)|uniprotkb:GRB2(gene name)|psi-mi:GRB2(display_short)|uniprotkb:ASH(gene name synonym)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)|uniprotkb:Protein Ash(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511053|imex:IM-12079-12 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006454.1|refseq:NP_964010.1|refseq:NP_998787.1|refseq:XP_005264145.1|refseq:XP_011530785.1|refseq:XP_016858664.1|go:"GO:0016020"(membrane)|go:"GO:0014067"(negative regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032154"(cleavage furrow)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0046872"(metal ion binding)|go:"GO:0061578"(Lys63-specific deubiquitinase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070122"(isopeptidase activity)|go:"GO:0070536"(protein K63-linked deubiquitination)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR015063(Region of unknown function DUF1873)|interpro:IPR037518|interpro:IPR044098|mint:O95630|rcsb pdb:2XZE|rcsb pdb:3RZU|rcsb pdb:3RZV|rcsb pdb:5IXF|reactome:R-HSA-5689901|ensembl:ENSG00000124356(gene)|ensembl:ENST00000339566(transcript)|ensembl:ENST00000394070(transcript)|ensembl:ENST00000394073(transcript)|ensembl:ENST00000409707(transcript)|ensembl:ENST00000682351(transcript)|ensembl:ENST00000682379(transcript)|ensembl:ENST00000682558(transcript)|ensembl:ENST00000682847(transcript)|ensembl:ENST00000683036(transcript)|ensembl:ENST00000683317(transcript)|ensembl:ENST00000683518(transcript)|ensembl:ENST00000683818(transcript)|ensembl:ENST00000684095(transcript)|ensembl:ENST00000684312(transcript)|ensembl:ENST00000684585(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|dip:DIP-33062N ensembl:ENSG00000177885(gene)|refseq:NP_002077.1|refseq:NP_987102.1|ensembl:ENST00000316804(transcript)|ensembl:ENST00000392562(transcript)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|ensembl:ENST00000392564(transcript)|ensembl:ENST00000648046(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031623"(receptor internalization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:P62993|rcsb pdb:1AZE|rcsb pdb:1BM2|rcsb pdb:1BMB|rcsb pdb:1CJ1|rcsb pdb:1FHS|rcsb pdb:1FYR|rcsb pdb:1GCQ|rcsb pdb:1GFC|rcsb pdb:1GFD|rcsb pdb:1GHU|rcsb pdb:1GRI|rcsb pdb:1IO6|rcsb pdb:1JYQ|rcsb pdb:1JYR|rcsb pdb:1JYU|rcsb pdb:1QG1|rcsb pdb:1TZE|rcsb pdb:1X0N|rcsb pdb:1ZFP|rcsb pdb:2AOA|rcsb pdb:2AOB|rcsb pdb:2H46|rcsb pdb:2H5K|rcsb pdb:2HUW|rcsb pdb:2VVK|rcsb pdb:2VWF|rcsb pdb:2W0Z|rcsb pdb:3C7I|rcsb pdb:3IMD|rcsb pdb:3IMJ|rcsb pdb:3IN7|rcsb pdb:3IN8|rcsb pdb:3KFJ|rcsb pdb:3MXC|rcsb pdb:3N7Y|rcsb pdb:3N84|rcsb pdb:3N8M|rcsb pdb:3OV1|rcsb pdb:3OVE|rcsb pdb:3MXY|rcsb pdb:3S8L|rcsb pdb:3S8N|rcsb pdb:3S8O|rcsb pdb:3WA4|rcsb pdb:4P9V|rcsb pdb:4P9Z|rcsb pdb:5CDW|rcsb pdb:6ICG|rcsb pdb:6ICH|rcsb pdb:6SDF|rcsb pdb:6VK2|rcsb pdb:6WM1|rcsb pdb:6WO2|reactome:R-HSA-109704|reactome:R-HSA-112412|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-1257604|reactome:R-HSA-1295596|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-167044|reactome:R-HSA-179812|reactome:R-HSA-180292|reactome:R-HSA-180336|reactome:R-HSA-182971|reactome:R-HSA-1839117|reactome:R-HSA-186763|reactome:R-HSA-1963640|reactome:R-HSA-1963642|reactome:R-HSA-2029482|reactome:R-HSA-210993|reactome:R-HSA-2179392|reactome:R-HSA-2219530|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-354194|reactome:R-HSA-375165|reactome:R-HSA-388841|reactome:R-HSA-389359|reactome:R-HSA-391160|reactome:R-HSA-512988|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654693|reactome:R-HSA-5654695|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654710|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5654720|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5655253|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5663213|reactome:R-HSA-5673001|reactome:R-HSA-6807004|reactome:R-HSA-6811558|reactome:R-HSA-74749|reactome:R-HSA-74751|reactome:R-HSA-8851805|reactome:R-HSA-8851907|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8865999|reactome:R-HSA-8875360|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-8983432|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9028335|reactome:R-HSA-5654689|reactome:R-HSA-9028731|reactome:R-HSA-9034864|reactome:R-HSA-912526|reactome:R-HSA-912631|reactome:R-HSA-9607240|reactome:R-HSA-9634285|reactome:R-HSA-9645135|reactome:R-HSA-9664422|reactome:R-HSA-9664565|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9674555|reactome:R-HSA-9702518|reactome:R-HSA-9703465|reactome:R-HSA-9703648|reactome:R-HSA-983695|dip:DIP-29229N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:JUvszgPz9rog/OEpmABJ295BaLw9606 rogid:SLnslQ7NHbnuK06nMVuRvJpoOA49606 intact-crc:F868603FE2BF80AC|rigid:sEnXxGIGbcDKnyGI0/x14wY/lnk false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O95630 uniprotkb:Q659F9 intact:EBI-396676|uniprotkb:Q3MJE7|uniprotkb:D6W5H7|uniprotkb:B5M0B6|ensembl:ENSP00000344742|ensembl:ENSP00000377633|ensembl:ENSP00000377636|ensembl:ENSP00000386548|ensembl:ENSP00000506833|ensembl:ENSP00000506845|ensembl:ENSP00000506865|ensembl:ENSP00000506958|ensembl:ENSP00000507014|ensembl:ENSP00000507054|ensembl:ENSP00000507081|ensembl:ENSP00000507092|ensembl:ENSP00000507639|ensembl:ENSP00000507658|ensembl:ENSP00000507864 intact:EBI-2511049 psi-mi:stabp_human(display_long)|uniprotkb:AMSH(gene name synonym)|uniprotkb:STAMBP(gene name)|psi-mi:STAMBP(display_short)|uniprotkb:Associated molecule with the SH3 domain of STAM(gene name synonym)|uniprotkb:Endosome-associated ubiquitin isopeptidase(gene name synonym) psi-mi:q659f9_human(display_long)|uniprotkb:DKFZp564E242(gene name)|psi-mi:DKFZp564E242(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511053|imex:IM-12079-12 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006454.1|refseq:NP_964010.1|refseq:NP_998787.1|refseq:XP_005264145.1|refseq:XP_011530785.1|refseq:XP_016858664.1|go:"GO:0016020"(membrane)|go:"GO:0014067"(negative regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032154"(cleavage furrow)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0046872"(metal ion binding)|go:"GO:0061578"(Lys63-specific deubiquitinase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070122"(isopeptidase activity)|go:"GO:0070536"(protein K63-linked deubiquitination)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR015063(Region of unknown function DUF1873)|interpro:IPR037518|interpro:IPR044098|mint:O95630|rcsb pdb:2XZE|rcsb pdb:3RZU|rcsb pdb:3RZV|rcsb pdb:5IXF|reactome:R-HSA-5689901|ensembl:ENSG00000124356(gene)|ensembl:ENST00000339566(transcript)|ensembl:ENST00000394070(transcript)|ensembl:ENST00000394073(transcript)|ensembl:ENST00000409707(transcript)|ensembl:ENST00000682351(transcript)|ensembl:ENST00000682379(transcript)|ensembl:ENST00000682558(transcript)|ensembl:ENST00000682847(transcript)|ensembl:ENST00000683036(transcript)|ensembl:ENST00000683317(transcript)|ensembl:ENST00000683518(transcript)|ensembl:ENST00000683818(transcript)|ensembl:ENST00000684095(transcript)|ensembl:ENST00000684312(transcript)|ensembl:ENST00000684585(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|dip:DIP-33062N go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0019784"(NEDD8-specific protease activity)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0071108"(protein K48-linked deubiquitination)|interpro:IPR003323(Ovarian tumour, otubain)|interpro:IPR019400|interpro:IPR016615(Ubiquitin thioesterase Otubain)|interpro:IPR030298|interpro:IPR042467|interpro:IPR042468|interpro:IPR038765 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:JUvszgPz9rog/OEpmABJ295BaLw9606 rogid:2bHmOml0I+XL31g2SUOu130dya89606 intact-crc:F868603FE2BF80AC|rigid:sEnXxGIGbcDKnyGI0/x14wY/lnk false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q0IIN1 intact:EBI-2511082 intact:EBI-2511085 - psi-mi:q0iin1_human(display_long)|uniprotkb:KRT77(gene name)|psi-mi:KRT77(display_short) psi-mi:ub6l1_human(display_short)|psi-mi:EBI-2511082(display_long)|uniprotkb:Protein TL13(gene name synonym)|uniprotkb:Proto-oncogene TRE-2-like protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511121|imex:IM-12079-13 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0045095"(keratin filament)|refseq:NP_778253.2|interpro:IPR018039|interpro:IPR003054(Type II keratin)|interpro:IPR032444|interpro:IPR039008 uniprotkb:O95482(uniprot-removed-ac) psi-mi:"MI:0469"(intact) - no-uniprot-update:|caution:The sequence has been withdrawn from uniprot. figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:a5ksXnU9Wj7tsqLex3Ti3+kgJyA9606 rogid:CZ4cwn8a37DquGKr049JqKnVaKk9606 intact-crc:7341DB56DA2185EF|rigid:8eQHPclcCmy5epklzUXYFJIGsE4 false - ha tag:n-n|flag tag:n-n - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UGI0 uniprotkb:Q5VSL9 intact:EBI-527853|uniprotkb:Q5SQP6|uniprotkb:B4DZ98|uniprotkb:Q69YK3|uniprotkb:D3DRF4|ensembl:ENSP00000352676 intact:EBI-1773588|uniprotkb:Q0V925|uniprotkb:Q5VSL8|uniprotkb:Q658K2|uniprotkb:Q6ZV31|uniprotkb:Q8N598|uniprotkb:Q96SN2|uniprotkb:Q9C0A2|ensembl:ENSP00000358810 psi-mi:zran1_human(display_long)|uniprotkb:Zinc finger Ran-binding domain-containing protein 1(gene name synonym)|uniprotkb:ZRANB1(gene name)|psi-mi:ZRANB1(display_short)|uniprotkb:TRABID(gene name synonym)|uniprotkb:TRAF-binding domain-containing protein(gene name synonym) psi-mi:strp1_human(display_long)|uniprotkb:STRIP1(gene name)|psi-mi:STRIP1(display_short)|uniprotkb:FAM40A(gene name synonym)|uniprotkb:KIAA1761(gene name synonym)|uniprotkb:Protein FAM40A(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511131|imex:IM-12079-64 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_060050.2|ensembl:ENSG00000019995(gene)|ensembl:ENST00000359653(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016477"(cell migration)|go:"GO:0022604"(regulation of cell morphogenesis)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0035523"(protein K29-linked deubiquitination)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046872"(metal ion binding)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071947"(protein deubiquitination involved in ubiquitin-dependent protein catabolic process)|go:"GO:1990168"(protein K33-linked deubiquitination)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR003323(Ovarian tumour, otubain)|interpro:IPR036443|interpro:IPR041294|mint:Q9UGI0|rcsb pdb:3ZRH|rcsb pdb:5AF6|reactome:R-HSA-195253|reactome:R-HSA-5689896|refseq:XP_005269983.1|dip:DIP-33806N|refseq:XP_016871846.1 refseq:NP_001257697.1|refseq:NP_149079.2|dip:DIP-51621N|ensembl:ENSG00000143093(gene)|ensembl:ENST00000369795(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0019901"(protein kinase binding)|go:"GO:0022604"(regulation of cell morphogenesis)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031267"(small GTPase binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR012486(N1221-like)|interpro:IPR021819|interpro:IPR040185|rcsb pdb:7K36 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:/cHOFsN7yB+8MUyL3cAG1v5MUAc9606 rogid:Uaui+Ip8PKEWNWx8z7r9iknuvLk9606 intact-crc:09F497E50CE2A114|rigid:vXGijXmDoDuwBohm+6YJ5/+/cm0 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UGI0 uniprotkb:O95819 intact:EBI-527853|uniprotkb:Q5SQP6|uniprotkb:B4DZ98|uniprotkb:Q69YK3|uniprotkb:D3DRF4|ensembl:ENSP00000352676 intact:EBI-2511133|intact:EBI-28985706|ensembl:ENSP00000314363|uniprotkb:Q9NST7|uniprotkb:O75172|uniprotkb:E7ESS2 psi-mi:zran1_human(display_long)|uniprotkb:Zinc finger Ran-binding domain-containing protein 1(gene name synonym)|uniprotkb:ZRANB1(gene name)|psi-mi:ZRANB1(display_short)|uniprotkb:TRABID(gene name synonym)|uniprotkb:TRAF-binding domain-containing protein(gene name synonym) psi-mi:m4k4_human(display_long)|uniprotkb:MAP4K4(gene name)|psi-mi:MAP4K4(display_short)|uniprotkb:HGK(gene name synonym)|uniprotkb:KIAA0687(gene name synonym)|uniprotkb:NIK(gene name synonym)|uniprotkb:MAPK/ERK kinase kinase kinase 4(gene name synonym)|uniprotkb:HPK/GCK-like kinase HGK(gene name synonym)|uniprotkb:Nck-interacting kinase(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511131|imex:IM-12079-64 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_060050.2|ensembl:ENSG00000019995(gene)|ensembl:ENST00000359653(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016477"(cell migration)|go:"GO:0022604"(regulation of cell morphogenesis)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0035523"(protein K29-linked deubiquitination)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046872"(metal ion binding)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071947"(protein deubiquitination involved in ubiquitin-dependent protein catabolic process)|go:"GO:1990168"(protein K33-linked deubiquitination)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR003323(Ovarian tumour, otubain)|interpro:IPR036443|interpro:IPR041294|mint:Q9UGI0|rcsb pdb:3ZRH|rcsb pdb:5AF6|reactome:R-HSA-195253|reactome:R-HSA-5689896|refseq:XP_005269983.1|dip:DIP-33806N|refseq:XP_016871846.1 refseq:NP_663719.2|ensembl:ENST00000347699(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0004111"(creatine kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008017"(microtubule binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032014"(positive regulation of ARF protein signal transduction)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0051549"(positive regulation of keratinocyte migration)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0061179"(negative regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0070571"(negative regulation of neuron projection regeneration)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120183"(positive regulation of focal adhesion disassembly)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:O95819|rcsb pdb:4OBO|rcsb pdb:4OBP|rcsb pdb:4OBQ|rcsb pdb:4RVT|rcsb pdb:4U3Y|rcsb pdb:4U3Z|rcsb pdb:4U40|rcsb pdb:4U41|rcsb pdb:4U42|rcsb pdb:4U43|rcsb pdb:4U44|rcsb pdb:4U45|rcsb pdb:4ZK5|rcsb pdb:4ZP5|rcsb pdb:5DI1|rcsb pdb:5J95|rcsb pdb:5W5Q|reactome:R-HSA-2559580|ensembl:ENSG00000071054(gene)|refseq:NP_001229488.1|refseq:NP_004825.3|refseq:NP_663720.1|ensembl:ENSP00000314363|ensembl:ENST00000350878|ensembl:ENSP00000343658|ensembl:ENST00000634702|ensembl:ENSP00000489579 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:/cHOFsN7yB+8MUyL3cAG1v5MUAc9606 rogid:wEXGp6vM4HhwldyeQJKvEdilMpQ9606 intact-crc:09F497E50CE2A114|rigid:vXGijXmDoDuwBohm+6YJ5/+/cm0 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UGI0 uniprotkb:Q9HB71 intact:EBI-527853|uniprotkb:Q5SQP6|uniprotkb:B4DZ98|uniprotkb:Q69YK3|uniprotkb:D3DRF4|ensembl:ENSP00000352676 intact:EBI-1047302|uniprotkb:O60666|ensembl:ENSP00000356652|uniprotkb:B2ZWH2|uniprotkb:Q5R371|uniprotkb:B3KSF1|uniprotkb:Q5R370 psi-mi:zran1_human(display_long)|uniprotkb:Zinc finger Ran-binding domain-containing protein 1(gene name synonym)|uniprotkb:ZRANB1(gene name)|psi-mi:ZRANB1(display_short)|uniprotkb:TRABID(gene name synonym)|uniprotkb:TRAF-binding domain-containing protein(gene name synonym) psi-mi:cybp_human(display_long)|uniprotkb:Siah-interacting protein(gene name synonym)|uniprotkb:S100A6-binding protein(gene name synonym)|uniprotkb:CACYBP(gene name)|psi-mi:CACYBP(display_short)|uniprotkb:S100A6BP(gene name synonym)|uniprotkb:SIP(gene name synonym)|uniprotkb:PNAS-107(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511131|imex:IM-12079-64 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_060050.2|ensembl:ENSG00000019995(gene)|ensembl:ENST00000359653(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016477"(cell migration)|go:"GO:0022604"(regulation of cell morphogenesis)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0035523"(protein K29-linked deubiquitination)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046872"(metal ion binding)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071947"(protein deubiquitination involved in ubiquitin-dependent protein catabolic process)|go:"GO:1990168"(protein K33-linked deubiquitination)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR003323(Ovarian tumour, otubain)|interpro:IPR036443|interpro:IPR041294|mint:Q9UGI0|rcsb pdb:3ZRH|rcsb pdb:5AF6|reactome:R-HSA-195253|reactome:R-HSA-5689896|refseq:XP_005269983.1|dip:DIP-33806N|refseq:XP_016871846.1 go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR015120(Siah interacting protein, N terminal)|interpro:IPR037201|interpro:IPR037893|mint:Q9HB71|rcsb pdb:1X5M|rcsb pdb:2A25|rcsb pdb:2A26|go:"GO:0071277"(cellular response to calcium ion)|refseq:NP_001007215.1|refseq:NP_055227.1|ensembl:ENSG00000116161(gene)|ensembl:ENST00000367679(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0015631"(tubulin binding)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0044297"(cell body)|go:"GO:0044548"(S100 protein binding)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0060416"(response to growth hormone)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070062"(extracellular exosome)|refseq:XP_016856535.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:/cHOFsN7yB+8MUyL3cAG1v5MUAc9606 rogid:mvv1o19mLHBS3FDnATyOFsDoZvk9606 intact-crc:09F497E50CE2A114|rigid:vXGijXmDoDuwBohm+6YJ5/+/cm0 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UGI0 uniprotkb:P30154 intact:EBI-527853|uniprotkb:Q5SQP6|uniprotkb:B4DZ98|uniprotkb:Q69YK3|uniprotkb:D3DRF4|ensembl:ENSP00000352676 intact:EBI-357094|uniprotkb:O75620|uniprotkb:Q8NHV8|uniprotkb:B0YJ69|intact:EBI-2559603|uniprotkb:B4DWW5|uniprotkb:B4DGQ6|uniprotkb:F8W8G1|uniprotkb:A8MY67|uniprotkb:B4DK91|ensembl:ENSP00000437193 psi-mi:zran1_human(display_long)|uniprotkb:Zinc finger Ran-binding domain-containing protein 1(gene name synonym)|uniprotkb:ZRANB1(gene name)|psi-mi:ZRANB1(display_short)|uniprotkb:TRABID(gene name synonym)|uniprotkb:TRAF-binding domain-containing protein(gene name synonym) psi-mi:2aab_human(display_long)|uniprotkb:PPP2R1B(gene name)|psi-mi:PPP2R1B(display_short)|uniprotkb:PP2A subunit A isoform PR65-beta(gene name synonym)|uniprotkb:PP2A subunit A isoform R1-beta(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511131|imex:IM-12079-64 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_060050.2|ensembl:ENSG00000019995(gene)|ensembl:ENST00000359653(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016477"(cell migration)|go:"GO:0022604"(regulation of cell morphogenesis)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0035523"(protein K29-linked deubiquitination)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046872"(metal ion binding)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071947"(protein deubiquitination involved in ubiquitin-dependent protein catabolic process)|go:"GO:1990168"(protein K33-linked deubiquitination)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR003323(Ovarian tumour, otubain)|interpro:IPR036443|interpro:IPR041294|mint:Q9UGI0|rcsb pdb:3ZRH|rcsb pdb:5AF6|reactome:R-HSA-195253|reactome:R-HSA-5689896|refseq:XP_005269983.1|dip:DIP-33806N|refseq:XP_016871846.1 dip:DIP-36616N|refseq:NP_001171033.1|refseq:NP_001171034.1|refseq:NP_002707.3|refseq:NP_859050.1|refseq:NP_859051.1|ensembl:ENST00000527614(transcript)|go:"GO:0000159"(protein phosphatase type 2A complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0045121"(membrane raft)|go:"GO:0060561"(apoptotic process involved in morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000357(HEAT)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR021133|mint:P30154|reactome:R-HSA-113501|reactome:R-HSA-141444|reactome:R-HSA-163685|reactome:R-HSA-163767|reactome:R-HSA-180024|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-198753|reactome:R-HSA-202670|reactome:R-HSA-2465910|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-389513|reactome:R-HSA-432142|reactome:R-HSA-4641262|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5467337|reactome:R-HSA-5467340|reactome:R-HSA-5467348|reactome:R-HSA-5663220|reactome:R-HSA-5673000|reactome:R-HSA-5675221|reactome:R-HSA-6804757|reactome:R-HSA-6811558|reactome:R-HSA-68877|reactome:R-HSA-69231|reactome:R-HSA-69273|reactome:R-HSA-9634600|reactome:R-HSA-9648025|ensembl:ENSG00000137713(gene) psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:/cHOFsN7yB+8MUyL3cAG1v5MUAc9606 rogid:fYgJ5+zyhLkZTUHV535I4LB+4iw9606 intact-crc:09F497E50CE2A114|rigid:vXGijXmDoDuwBohm+6YJ5/+/cm0 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UGI0 uniprotkb:Q9ULQ0 intact:EBI-527853|uniprotkb:Q5SQP6|uniprotkb:B4DZ98|uniprotkb:Q69YK3|uniprotkb:D3DRF4|ensembl:ENSP00000352676 intact:EBI-1774281|uniprotkb:Q8WUZ4|ensembl:ENSP00000249344 psi-mi:zran1_human(display_long)|uniprotkb:Zinc finger Ran-binding domain-containing protein 1(gene name synonym)|uniprotkb:ZRANB1(gene name)|psi-mi:ZRANB1(display_short)|uniprotkb:TRABID(gene name synonym)|uniprotkb:TRAF-binding domain-containing protein(gene name synonym) psi-mi:strp2_human(display_long)|uniprotkb:STRIP2(gene name)|psi-mi:STRIP2(display_short)|uniprotkb:FAM40B(gene name synonym)|uniprotkb:KIAA1170(gene name synonym)|uniprotkb:Protein FAM40B(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511131|imex:IM-12079-64 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_060050.2|ensembl:ENSG00000019995(gene)|ensembl:ENST00000359653(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016477"(cell migration)|go:"GO:0022604"(regulation of cell morphogenesis)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0035523"(protein K29-linked deubiquitination)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046872"(metal ion binding)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071947"(protein deubiquitination involved in ubiquitin-dependent protein catabolic process)|go:"GO:1990168"(protein K33-linked deubiquitination)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR003323(Ovarian tumour, otubain)|interpro:IPR036443|interpro:IPR041294|mint:Q9UGI0|rcsb pdb:3ZRH|rcsb pdb:5AF6|reactome:R-HSA-195253|reactome:R-HSA-5689896|refseq:XP_005269983.1|dip:DIP-33806N|refseq:XP_016871846.1 refseq:NP_001127808.1|refseq:NP_065755.1|dip:DIP-51635N|ensembl:ENSG00000128578(gene)|ensembl:ENST00000249344(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016477"(cell migration)|interpro:IPR012486(N1221-like)|interpro:IPR021819|interpro:IPR040185 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:/cHOFsN7yB+8MUyL3cAG1v5MUAc9606 rogid:w3e2uSAwxlTpCwTLlCTK9pUBhP89606 intact-crc:09F497E50CE2A114|rigid:vXGijXmDoDuwBohm+6YJ5/+/cm0 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UGI0 uniprotkb:Q9NVK5 intact:EBI-527853|uniprotkb:Q5SQP6|uniprotkb:B4DZ98|uniprotkb:Q69YK3|uniprotkb:D3DRF4|ensembl:ENSP00000352676 intact:EBI-1104764|uniprotkb:Q6R955|uniprotkb:Q8N5L7|uniprotkb:Q9P034|uniprotkb:Q9UFK8|ensembl:ENSP00000229395 psi-mi:zran1_human(display_long)|uniprotkb:Zinc finger Ran-binding domain-containing protein 1(gene name synonym)|uniprotkb:ZRANB1(gene name)|psi-mi:ZRANB1(display_short)|uniprotkb:TRABID(gene name synonym)|uniprotkb:TRAF-binding domain-containing protein(gene name synonym) psi-mi:fgop2_human(display_long)|uniprotkb:FGFR1OP2(gene name)|psi-mi:FGFR1OP2(display_short)|uniprotkb:HSPC123(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511131|imex:IM-12079-64 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_060050.2|ensembl:ENSG00000019995(gene)|ensembl:ENST00000359653(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016477"(cell migration)|go:"GO:0022604"(regulation of cell morphogenesis)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0035523"(protein K29-linked deubiquitination)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046872"(metal ion binding)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071947"(protein deubiquitination involved in ubiquitin-dependent protein catabolic process)|go:"GO:1990168"(protein K33-linked deubiquitination)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR003323(Ovarian tumour, otubain)|interpro:IPR036443|interpro:IPR041294|mint:Q9UGI0|rcsb pdb:3ZRH|rcsb pdb:5AF6|reactome:R-HSA-195253|reactome:R-HSA-5689896|refseq:XP_005269983.1|dip:DIP-33806N|refseq:XP_016871846.1 ensembl:ENSG00000111790(gene)|ensembl:ENST00000229395(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0009611"(response to wounding)|go:"GO:0042060"(wound healing)|go:"GO:0042802"(identical protein binding)|interpro:IPR008555(Protein of unknown function DUF837)|reactome:R-HSA-1839117|reactome:R-HSA-5655302|refseq:NP_001165358.1|refseq:NP_001165359.1|refseq:NP_056448.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:/cHOFsN7yB+8MUyL3cAG1v5MUAc9606 rogid:jXd4sql3WIYvX9V2SbahQYPNMOY9606 intact-crc:09F497E50CE2A114|rigid:vXGijXmDoDuwBohm+6YJ5/+/cm0 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UGI0 uniprotkb:O95714 intact:EBI-527853|uniprotkb:Q5SQP6|uniprotkb:B4DZ98|uniprotkb:Q69YK3|uniprotkb:D3DRF4|ensembl:ENSP00000352676 intact:EBI-1058922|uniprotkb:Q86SV7|uniprotkb:Q86SV8|uniprotkb:Q86SV9|uniprotkb:Q86YY3|uniprotkb:Q86YY4|uniprotkb:Q86YY5|uniprotkb:Q86YY6|uniprotkb:Q86YY7|uniprotkb:Q86YY8|uniprotkb:Q86YY9|uniprotkb:Q86YZ0|uniprotkb:Q86YZ1|intact:EBI-1104961|intact:EBI-28977852|ensembl:ENSP00000261609 psi-mi:zran1_human(display_long)|uniprotkb:Zinc finger Ran-binding domain-containing protein 1(gene name synonym)|uniprotkb:ZRANB1(gene name)|psi-mi:ZRANB1(display_short)|uniprotkb:TRABID(gene name synonym)|uniprotkb:TRAF-binding domain-containing protein(gene name synonym) psi-mi:herc2_human(display_long)|uniprotkb:HERC2(gene name)|psi-mi:HERC2(display_short)|uniprotkb:HECT domain and RCC1-like domain-containing protein 2(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase HERC2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511131|imex:IM-12079-64 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_060050.2|ensembl:ENSG00000019995(gene)|ensembl:ENST00000359653(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016477"(cell migration)|go:"GO:0022604"(regulation of cell morphogenesis)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0035523"(protein K29-linked deubiquitination)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046872"(metal ion binding)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071947"(protein deubiquitination involved in ubiquitin-dependent protein catabolic process)|go:"GO:1990168"(protein K33-linked deubiquitination)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR003323(Ovarian tumour, otubain)|interpro:IPR036443|interpro:IPR041294|mint:Q9UGI0|rcsb pdb:3ZRH|rcsb pdb:5AF6|reactome:R-HSA-195253|reactome:R-HSA-5689896|refseq:XP_005269983.1|dip:DIP-33806N|refseq:XP_016871846.1 ensembl:ENSP00000261609|refseq:NP_004658.3|ensembl:ENSG00000128731(gene)|ensembl:ENST00000261609(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006281"(DNA repair)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032183"(SUMO binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR000433(Zinc finger, ZZ-type)|interpro:IPR000569(HECT)|interpro:IPR001199(Cytochrome b5)|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR006624(Beta-propeller repeat TECPR)|interpro:IPR008979(Galactose-binding like)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR010606(Mib-herc2)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR021097|interpro:IPR035983|interpro:IPR036400|interpro:IPR037252|interpro:IPR037976|interpro:IPR041987|interpro:IPR043145|mint:O95714|rcsb pdb:2KEO|go:"GO:0031625"(ubiquitin protein ligase binding)|rcsb pdb:3KCI|rcsb pdb:4L1M|rcsb pdb:6WW4|reactome:R-HSA-3108214|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473|reactome:R-HSA-983168|rcsb pdb:6WW3|dip:DIP-37632N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:/cHOFsN7yB+8MUyL3cAG1v5MUAc9606 rogid:ejMTmb0F9pM7zfHbRscV1rIRgSw9606 intact-crc:09F497E50CE2A114|rigid:vXGijXmDoDuwBohm+6YJ5/+/cm0 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UGI0 uniprotkb:Q9P2B4 intact:EBI-527853|uniprotkb:Q5SQP6|uniprotkb:B4DZ98|uniprotkb:Q69YK3|uniprotkb:D3DRF4|ensembl:ENSP00000352676 intact:EBI-1774273|uniprotkb:Q96B40|uniprotkb:B3KMS5|ensembl:ENSP00000271277 psi-mi:zran1_human(display_long)|uniprotkb:Zinc finger Ran-binding domain-containing protein 1(gene name synonym)|uniprotkb:ZRANB1(gene name)|psi-mi:ZRANB1(display_short)|uniprotkb:TRABID(gene name synonym)|uniprotkb:TRAF-binding domain-containing protein(gene name synonym) psi-mi:ct2nl_human(display_long)|uniprotkb:CTTNBP2NL(gene name)|psi-mi:CTTNBP2NL(display_short)|uniprotkb:KIAA1433(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511131|imex:IM-12079-64 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_060050.2|ensembl:ENSG00000019995(gene)|ensembl:ENST00000359653(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016477"(cell migration)|go:"GO:0022604"(regulation of cell morphogenesis)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0035523"(protein K29-linked deubiquitination)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046872"(metal ion binding)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071947"(protein deubiquitination involved in ubiquitin-dependent protein catabolic process)|go:"GO:1990168"(protein K33-linked deubiquitination)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR003323(Ovarian tumour, otubain)|interpro:IPR036443|interpro:IPR041294|mint:Q9UGI0|rcsb pdb:3ZRH|rcsb pdb:5AF6|reactome:R-HSA-195253|reactome:R-HSA-5689896|refseq:XP_005269983.1|dip:DIP-33806N|refseq:XP_016871846.1 refseq:XP_011540083.1|refseq:NP_061174.1|ensembl:ENSP00000271277|refseq:XP_016857295.1|ensembl:ENSG00000143079(gene)|ensembl:ENST00000271277(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0032410"(negative regulation of transporter activity)|go:"GO:0034763"(negative regulation of transmembrane transport)|go:"GO:0051721"(protein phosphatase 2A binding)|interpro:IPR019131|go:"GO:0030027"(lamellipodium) psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:/cHOFsN7yB+8MUyL3cAG1v5MUAc9606 rogid:4IOUiHNAw5RSokCYTBZVDROR+UY9606 intact-crc:09F497E50CE2A114|rigid:vXGijXmDoDuwBohm+6YJ5/+/cm0 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UGI0 uniprotkb:O43815 intact:EBI-527853|uniprotkb:Q5SQP6|uniprotkb:B4DZ98|uniprotkb:Q69YK3|uniprotkb:D3DRF4|ensembl:ENSP00000352676 intact:EBI-1046642|uniprotkb:Q3KP65|ensembl:ENSP00000263918|uniprotkb:Q53TQ8|uniprotkb:Q9NP38 psi-mi:zran1_human(display_long)|uniprotkb:Zinc finger Ran-binding domain-containing protein 1(gene name synonym)|uniprotkb:ZRANB1(gene name)|psi-mi:ZRANB1(display_short)|uniprotkb:TRABID(gene name synonym)|uniprotkb:TRAF-binding domain-containing protein(gene name synonym) psi-mi:strn_human(display_long)|uniprotkb:STRN(gene name)|psi-mi:STRN(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511131|imex:IM-12079-64 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_060050.2|ensembl:ENSG00000019995(gene)|ensembl:ENST00000359653(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016477"(cell migration)|go:"GO:0022604"(regulation of cell morphogenesis)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0035523"(protein K29-linked deubiquitination)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046872"(metal ion binding)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071947"(protein deubiquitination involved in ubiquitin-dependent protein catabolic process)|go:"GO:1990168"(protein K33-linked deubiquitination)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR003323(Ovarian tumour, otubain)|interpro:IPR036443|interpro:IPR041294|mint:Q9UGI0|rcsb pdb:3ZRH|rcsb pdb:5AF6|reactome:R-HSA-195253|reactome:R-HSA-5689896|refseq:XP_005269983.1|dip:DIP-33806N|refseq:XP_016871846.1 refseq:NP_003153.2|ensembl:ENSG00000115808(gene)|ensembl:ENST00000263918(transcript)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016358"(dendrite development)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030425"(dendrite)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0014069"(postsynaptic density)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0070016"(armadillo repeat domain binding)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0090443"(FAR/SIN/STRIPAK complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR013258(Striatin, N-terminal)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR020472|interpro:IPR036322|mint:O43815|reactome:R-HSA-1257604|reactome:R-HSA-2219530|reactome:R-HSA-6811558|reactome:R-HSA-9009391|reactome:R-HSA-9673766|interpro:IPR019775 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:/cHOFsN7yB+8MUyL3cAG1v5MUAc9606 rogid:SZjVHxPmRxYLTSqSLJo6jiXlzjQ9606 intact-crc:09F497E50CE2A114|rigid:vXGijXmDoDuwBohm+6YJ5/+/cm0 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UGI0 uniprotkb:Q9Y3A3 intact:EBI-527853|uniprotkb:Q5SQP6|uniprotkb:B4DZ98|uniprotkb:Q69YK3|uniprotkb:D3DRF4|ensembl:ENSP00000352676 intact:EBI-713935|uniprotkb:Q7Z4Y6|uniprotkb:Q9H2P3|uniprotkb:Q53SE0|uniprotkb:Q9H5J1|uniprotkb:Q9Y4T8|ensembl:ENSP00000315702|uniprotkb:B4DML0 psi-mi:zran1_human(display_long)|uniprotkb:Zinc finger Ran-binding domain-containing protein 1(gene name synonym)|uniprotkb:ZRANB1(gene name)|psi-mi:ZRANB1(display_short)|uniprotkb:TRABID(gene name synonym)|uniprotkb:TRAF-binding domain-containing protein(gene name synonym) psi-mi:phocn_human(display_long)|uniprotkb:MOB4(gene name)|psi-mi:MOB4(display_short)|uniprotkb:2C4D(gene name synonym)|uniprotkb:Class II mMOB1(gene name synonym)|uniprotkb:MOB3(gene name synonym)|uniprotkb:MOBKL3(gene name synonym)|uniprotkb:Mob1 homolog 3(gene name synonym)|uniprotkb:Mps one binder kinase activator-like 3(gene name synonym)|uniprotkb:PHOCN(gene name synonym)|uniprotkb:PREI3(gene name synonym)|uniprotkb:Preimplantation protein 3(gene name synonym)|uniprotkb:CGI-95(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511131|imex:IM-12079-64 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_060050.2|ensembl:ENSG00000019995(gene)|ensembl:ENST00000359653(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016477"(cell migration)|go:"GO:0022604"(regulation of cell morphogenesis)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0035523"(protein K29-linked deubiquitination)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046872"(metal ion binding)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071947"(protein deubiquitination involved in ubiquitin-dependent protein catabolic process)|go:"GO:1990168"(protein K33-linked deubiquitination)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR003323(Ovarian tumour, otubain)|interpro:IPR036443|interpro:IPR041294|mint:Q9UGI0|rcsb pdb:3ZRH|rcsb pdb:5AF6|reactome:R-HSA-195253|reactome:R-HSA-5689896|refseq:XP_005269983.1|dip:DIP-33806N|refseq:XP_016871846.1 ensembl:ENSG00000115540(gene)|ensembl:ENST00000323303(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0032580"(Golgi cisterna membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|interpro:IPR005301(Mob1/phocein)|interpro:IPR036703|mint:Q9Y3A3|rcsb pdb:5YF4|rcsb pdb:7K36|refseq:NP_001094289.1|refseq:NP_001191023.1|refseq:NP_056202.2|refseq:NP_955776.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:/cHOFsN7yB+8MUyL3cAG1v5MUAc9606 rogid:ihsb3qrdGqwKdh6ZhHlJlwBGJbc9606 intact-crc:09F497E50CE2A114|rigid:vXGijXmDoDuwBohm+6YJ5/+/cm0 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UGI0 uniprotkb:P54886 intact:EBI-527853|uniprotkb:Q5SQP6|uniprotkb:B4DZ98|uniprotkb:Q69YK3|uniprotkb:D3DRF4|ensembl:ENSP00000352676 intact:EBI-1210304|ensembl:ENSP00000360268|uniprotkb:O95952|uniprotkb:Q5T566|uniprotkb:Q9UM72|uniprotkb:Q3KQU2|uniprotkb:B2R5Q4|uniprotkb:B7Z350|uniprotkb:B7Z5X8|uniprotkb:B7ZLP1|uniprotkb:Q5T567|uniprotkb:D3DR44 psi-mi:zran1_human(display_long)|uniprotkb:Zinc finger Ran-binding domain-containing protein 1(gene name synonym)|uniprotkb:ZRANB1(gene name)|psi-mi:ZRANB1(display_short)|uniprotkb:TRABID(gene name synonym)|uniprotkb:TRAF-binding domain-containing protein(gene name synonym) psi-mi:p5cs_human(display_long)|uniprotkb:ALDH18A1(gene name)|psi-mi:ALDH18A1(display_short)|uniprotkb:P5CS(gene name synonym)|uniprotkb:PYCS(gene name synonym)|uniprotkb:GSAS(gene name synonym)|uniprotkb:Aldehyde dehydrogenase family 18 member A1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511131|imex:IM-12079-64 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_060050.2|ensembl:ENSG00000019995(gene)|ensembl:ENST00000359653(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016477"(cell migration)|go:"GO:0022604"(regulation of cell morphogenesis)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0035523"(protein K29-linked deubiquitination)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046872"(metal ion binding)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071947"(protein deubiquitination involved in ubiquitin-dependent protein catabolic process)|go:"GO:1990168"(protein K33-linked deubiquitination)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR003323(Ovarian tumour, otubain)|interpro:IPR036443|interpro:IPR041294|mint:Q9UGI0|rcsb pdb:3ZRH|rcsb pdb:5AF6|reactome:R-HSA-195253|reactome:R-HSA-5689896|refseq:XP_005269983.1|dip:DIP-33806N|refseq:XP_016871846.1 ensembl:ENSG00000059573(gene)|ensembl:ENST00000371224(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004349"(glutamate 5-kinase activity)|go:"GO:0004350"(glutamate-5-semialdehyde dehydrogenase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006536"(glutamate metabolic process)|go:"GO:0006561"(proline biosynthetic process)|go:"GO:0006592"(ornithine biosynthetic process)|go:"GO:0019240"(citrulline biosynthetic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0055129"(L-proline biosynthetic process)|interpro:IPR000965(Gamma-glutamyl phosphate reductase GPR)|interpro:IPR001048(Aspartate/glutamate/uridylate kinase)|refseq:NP_001017423.1|refseq:NP_002851.2|refseq:NP_001310341.1|refseq:NP_001310342.1|refseq:NP_001310343.1|refseq:NP_001310344.1|refseq:NP_001310345.1|refseq:NP_001310348.1|interpro:IPR001057(Glutamate 5-kinase)|interpro:IPR005715(Glutamate 5-kinase, ProB-related)|interpro:IPR005766(delta l-pyrroline-5-carboxylate synthetase)|interpro:IPR015590(Aldehyde dehydrogenase)|interpro:IPR016161(Aldehyde/histidinol dehydrogenase)|interpro:IPR016162(Aldehyde dehydrogenase, N-terminal)|interpro:IPR016163(Aldehyde dehydrogenase, C-terminal)|interpro:IPR019797|interpro:IPR020593|interpro:IPR036393|interpro:IPR041744|mint:P54886|rcsb pdb:2H5G|reactome:R-HSA-8964539 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:/cHOFsN7yB+8MUyL3cAG1v5MUAc9606 rogid:NLYlqQhi3HebSXYBxkkSmKplRCM9606 intact-crc:09F497E50CE2A114|rigid:vXGijXmDoDuwBohm+6YJ5/+/cm0 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UGI0 uniprotkb:Q8IWJ2 intact:EBI-527853|uniprotkb:Q5SQP6|uniprotkb:B4DZ98|uniprotkb:Q69YK3|uniprotkb:D3DRF4|ensembl:ENSP00000352676 intact:EBI-1645320|uniprotkb:O15045|uniprotkb:Q4ZG46|uniprotkb:Q8TDH3|uniprotkb:Q9H2G8|uniprotkb:A6H8X8|intact:EBI-1645335|intact:EBI-28984280|ensembl:ENSP00000307939 psi-mi:zran1_human(display_long)|uniprotkb:Zinc finger Ran-binding domain-containing protein 1(gene name synonym)|uniprotkb:ZRANB1(gene name)|psi-mi:ZRANB1(display_short)|uniprotkb:TRABID(gene name synonym)|uniprotkb:TRAF-binding domain-containing protein(gene name synonym) psi-mi:gcc2_human(display_long)|uniprotkb:GCC2(gene name)|psi-mi:GCC2(display_short)|uniprotkb:KIAA0336(gene name synonym)|uniprotkb:RANBP2L4(gene name synonym)|uniprotkb:185 kDa Golgi coiled-coil protein(gene name synonym)|uniprotkb:Ran-binding protein 2-like 4(gene name synonym)|uniprotkb:CTCL tumor antigen se1-1(gene name synonym)|uniprotkb:CLL-associated antigen KW-11(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-53(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511131|imex:IM-12079-64 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_060050.2|ensembl:ENSG00000019995(gene)|ensembl:ENST00000359653(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016477"(cell migration)|go:"GO:0022604"(regulation of cell morphogenesis)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0035523"(protein K29-linked deubiquitination)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046872"(metal ion binding)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071947"(protein deubiquitination involved in ubiquitin-dependent protein catabolic process)|go:"GO:1990168"(protein K33-linked deubiquitination)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR003323(Ovarian tumour, otubain)|interpro:IPR036443|interpro:IPR041294|mint:Q9UGI0|rcsb pdb:3ZRH|rcsb pdb:5AF6|reactome:R-HSA-195253|reactome:R-HSA-5689896|refseq:XP_005269983.1|dip:DIP-33806N|refseq:XP_016871846.1 refseq:NP_852118.1|refseq:XP_006712934.1|ensembl:ENSP00000307939|ensembl:ENST00000482325|ensembl:ENSP00000419969|ensembl:ENSG00000135968(gene)|ensembl:ENST00000309863(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0006622"(protein targeting to lysosome)|go:"GO:0016020"(membrane)|go:"GO:0031023"(microtubule organizing center organization)|go:"GO:0031267"(small GTPase binding)|go:"GO:0034067"(protein localization to Golgi apparatus)|go:"GO:0034453"(microtubule anchoring)|go:"GO:0034499"(late endosome to Golgi transport)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0042802"(identical protein binding)|go:"GO:0070861"(regulation of protein exit from endoplasmic reticulum)|go:"GO:0071955"(recycling endosome to Golgi transport)|go:"GO:0090161"(Golgi ribbon formation)|interpro:IPR000237(GRIP)|interpro:IPR032023|rcsb pdb:3BBP|reactome:R-HSA-6811440 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:/cHOFsN7yB+8MUyL3cAG1v5MUAc9606 rogid:YeL/V7QABi3DbamH+qE6WfFLAco9606 intact-crc:09F497E50CE2A114|rigid:vXGijXmDoDuwBohm+6YJ5/+/cm0 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UGI0 uniprotkb:Q8WZ74 intact:EBI-527853|uniprotkb:Q5SQP6|uniprotkb:B4DZ98|uniprotkb:Q69YK3|uniprotkb:D3DRF4|ensembl:ENSP00000352676 intact:EBI-1774260|uniprotkb:O43389|uniprotkb:Q7LG11|uniprotkb:Q9C0A5|intact:EBI-28975424|ensembl:ENSP00000160373 psi-mi:zran1_human(display_long)|uniprotkb:Zinc finger Ran-binding domain-containing protein 1(gene name synonym)|uniprotkb:ZRANB1(gene name)|psi-mi:ZRANB1(display_short)|uniprotkb:TRABID(gene name synonym)|uniprotkb:TRAF-binding domain-containing protein(gene name synonym) psi-mi:cttb2_human(display_long)|uniprotkb:CTTNBP2(gene name)|psi-mi:CTTNBP2(display_short)|uniprotkb:C7orf8(gene name synonym)|uniprotkb:CORTBP2(gene name synonym)|uniprotkb:KIAA1758(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511131|imex:IM-12079-64 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_060050.2|ensembl:ENSG00000019995(gene)|ensembl:ENST00000359653(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016477"(cell migration)|go:"GO:0022604"(regulation of cell morphogenesis)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0035523"(protein K29-linked deubiquitination)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046872"(metal ion binding)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071947"(protein deubiquitination involved in ubiquitin-dependent protein catabolic process)|go:"GO:1990168"(protein K33-linked deubiquitination)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR003323(Ovarian tumour, otubain)|interpro:IPR036443|interpro:IPR041294|mint:Q9UGI0|rcsb pdb:3ZRH|rcsb pdb:5AF6|reactome:R-HSA-195253|reactome:R-HSA-5689896|refseq:XP_005269983.1|dip:DIP-33806N|refseq:XP_016871846.1 ensembl:ENSP00000160373|refseq:NP_219499.1|ensembl:ENSG00000077063(gene)|ensembl:ENST00000160373(transcript)|go:"GO:0005938"(cell cortex)|go:"GO:0007420"(brain development)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0043197"(dendritic spine)|go:"GO:0098871"(postsynaptic actin cytoskeleton)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|interpro:IPR002110(Ankyrin)|interpro:IPR019131|interpro:IPR020683|interpro:IPR036770 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:/cHOFsN7yB+8MUyL3cAG1v5MUAc9606 rogid:c2nhzEGTnUzKWlGu+9TbZ+rEYEo9606 intact-crc:09F497E50CE2A114|rigid:vXGijXmDoDuwBohm+6YJ5/+/cm0 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UGI0 uniprotkb:Q14145 intact:EBI-527853|uniprotkb:Q5SQP6|uniprotkb:B4DZ98|uniprotkb:Q69YK3|uniprotkb:D3DRF4|ensembl:ENSP00000352676 intact:EBI-751001|uniprotkb:B3KPD5|uniprotkb:Q8WTX1|uniprotkb:Q6LEP0|uniprotkb:Q9BPY9|intact:EBI-28976014|ensembl:ENSP00000171111|ensembl:ENSP00000377245 psi-mi:zran1_human(display_long)|uniprotkb:Zinc finger Ran-binding domain-containing protein 1(gene name synonym)|uniprotkb:ZRANB1(gene name)|psi-mi:ZRANB1(display_short)|uniprotkb:TRABID(gene name synonym)|uniprotkb:TRAF-binding domain-containing protein(gene name synonym) psi-mi:keap1_human(display_long)|uniprotkb:Cytosolic inhibitor of Nrf2(gene name synonym)|uniprotkb:Kelch-like protein 19(gene name synonym)|uniprotkb:KEAP1(gene name)|psi-mi:KEAP1(display_short)|uniprotkb:INRF2(gene name synonym)|uniprotkb:KIAA0132(gene name synonym)|uniprotkb:KLHL19(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511131|imex:IM-12079-64 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_060050.2|ensembl:ENSG00000019995(gene)|ensembl:ENST00000359653(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016477"(cell migration)|go:"GO:0022604"(regulation of cell morphogenesis)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0035523"(protein K29-linked deubiquitination)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046872"(metal ion binding)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071947"(protein deubiquitination involved in ubiquitin-dependent protein catabolic process)|go:"GO:1990168"(protein K33-linked deubiquitination)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR003323(Ovarian tumour, otubain)|interpro:IPR036443|interpro:IPR041294|mint:Q9UGI0|rcsb pdb:3ZRH|rcsb pdb:5AF6|reactome:R-HSA-195253|reactome:R-HSA-5689896|refseq:XP_005269983.1|dip:DIP-33806N|refseq:XP_016871846.1 refseq:NP_036421.2|refseq:NP_987096.1|ensembl:ENSP00000171111|ensembl:ENSP00000377245|refseq:XP_011526754.1|refseq:XP_005260230.1|refseq:XP_005260231.1|dip:DIP-42134N|ensembl:ENSG00000079999(gene)|ensembl:ENST00000171111(transcript)|ensembl:ENST00000393623(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016234"(inclusion body)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030496"(midbody)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0042802"(identical protein binding)|go:"GO:0042994"(cytoplasmic sequestering of transcription factor)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045604"(regulation of epidermal cell differentiation)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0097718"(disordered domain specific binding)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR011705(BTB/Kelch-associated)|interpro:IPR015915(Kelch-type beta propeller)|interpro:IPR017096(Kelch-like protein, gigaxonin)|interpro:IPR030563|mint:Q14145|rcsb pdb:1U6D|rcsb pdb:1ZGK|rcsb pdb:2FLU|rcsb pdb:3VNG|rcsb pdb:3VNH|rcsb pdb:3ZGC|rcsb pdb:3ZGD|rcsb pdb:4CXI|rcsb pdb:4CXJ|rcsb pdb:4CXT|rcsb pdb:4IFJ|rcsb pdb:4IFL|rcsb pdb:4IFN|rcsb pdb:4IN4|rcsb pdb:4IQK|rcsb pdb:4L7B|rcsb pdb:4L7C|rcsb pdb:4L7D|rcsb pdb:4N1B|rcsb pdb:4XMB|rcsb pdb:5DAD|rcsb pdb:5DAF|rcsb pdb:5F72|rcsb pdb:5GIT|rcsb pdb:5NLB|rcsb pdb:5WFL|rcsb pdb:5WFV|rcsb pdb:5WG1|rcsb pdb:5WHL|rcsb pdb:5WHO|rcsb pdb:5WIY|rcsb pdb:5X54|rcsb pdb:6FFM|rcsb pdb:6FMP|rcsb pdb:6FMQ|rcsb pdb:6HWS|rcsb pdb:6LRZ|rcsb pdb:6ROG|rcsb pdb:6SP1|rcsb pdb:6SP4|rcsb pdb:6T7V|rcsb pdb:6T7Z|rcsb pdb:6TG8|rcsb pdb:6TYM|rcsb pdb:6TYP|rcsb pdb:6UF0|rcsb pdb:6W66|rcsb pdb:6W67|rcsb pdb:6W68|rcsb pdb:6W69|rcsb pdb:6WCQ|rcsb pdb:6Z6A|rcsb pdb:7K28|rcsb pdb:7K29|rcsb pdb:7K2A|rcsb pdb:7K2B|rcsb pdb:7K2C|rcsb pdb:7K2D|rcsb pdb:7K2E|rcsb pdb:7K2F|rcsb pdb:7K2G|rcsb pdb:7K2H|rcsb pdb:7K2I|rcsb pdb:7K2J|rcsb pdb:7K2K|rcsb pdb:7K2L|rcsb pdb:7K2M|rcsb pdb:7K2N|rcsb pdb:7K2O|rcsb pdb:7K2P|rcsb pdb:7K2Q|rcsb pdb:7K2R|rcsb pdb:7K2S|reactome:R-HSA-5689880|reactome:R-HSA-8932339|reactome:R-HSA-8951664|reactome:R-HSA-983168|rcsb pdb:6V6Z psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:/cHOFsN7yB+8MUyL3cAG1v5MUAc9606 rogid:3y/KqnUK+5nIyjhOEfkkthmP1OA9606 intact-crc:09F497E50CE2A114|rigid:vXGijXmDoDuwBohm+6YJ5/+/cm0 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UGI0 uniprotkb:Q96HS1 intact:EBI-527853|uniprotkb:Q5SQP6|uniprotkb:B4DZ98|uniprotkb:Q69YK3|uniprotkb:D3DRF4|ensembl:ENSP00000352676 intact:EBI-713608|uniprotkb:Q96JB0|intact:EBI-2555528|ensembl:ENSP00000438465|uniprotkb:C9IZY7|uniprotkb:A9LN06 psi-mi:zran1_human(display_long)|uniprotkb:Zinc finger Ran-binding domain-containing protein 1(gene name synonym)|uniprotkb:ZRANB1(gene name)|psi-mi:ZRANB1(display_short)|uniprotkb:TRABID(gene name synonym)|uniprotkb:TRAF-binding domain-containing protein(gene name synonym) psi-mi:pgam5_human(display_long)|uniprotkb:Bcl-XL-binding protein v68(gene name synonym)|uniprotkb:PGAM5(gene name)|psi-mi:PGAM5(display_short)|uniprotkb:Phosphoglycerate mutase family member 5(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511131|imex:IM-12079-64 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_060050.2|ensembl:ENSG00000019995(gene)|ensembl:ENST00000359653(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016477"(cell migration)|go:"GO:0022604"(regulation of cell morphogenesis)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0035523"(protein K29-linked deubiquitination)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046872"(metal ion binding)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071947"(protein deubiquitination involved in ubiquitin-dependent protein catabolic process)|go:"GO:1990168"(protein K33-linked deubiquitination)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR003323(Ovarian tumour, otubain)|interpro:IPR036443|interpro:IPR041294|mint:Q9UGI0|rcsb pdb:3ZRH|rcsb pdb:5AF6|reactome:R-HSA-195253|reactome:R-HSA-5689896|refseq:XP_005269983.1|dip:DIP-33806N|refseq:XP_016871846.1 refseq:NP_001164014.1|refseq:NP_612642.2|ensembl:ENSG00000247077(gene)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016236"(macroautophagy)|go:"GO:0016791"(phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0070266"(necroptotic process)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|interpro:IPR013078(Phosphoglycerate mutase)|interpro:IPR029033|mint:Q96HS1|rcsb pdb:3MXO|rcsb pdb:3O0T|rcsb pdb:5MUF|rcsb pdb:6CNI|rcsb pdb:6CNL|reactome:R-HSA-8934903|ensembl:ENST00000498926(transcript)|dip:DIP-50735N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:/cHOFsN7yB+8MUyL3cAG1v5MUAc9606 rogid:prE0I+tNIEjN9Y1NBZbh51DY2+Q9606 intact-crc:09F497E50CE2A114|rigid:vXGijXmDoDuwBohm+6YJ5/+/cm0 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UGI0 uniprotkb:Q9ULT8 intact:EBI-527853|uniprotkb:Q5SQP6|uniprotkb:B4DZ98|uniprotkb:Q69YK3|uniprotkb:D3DRF4|ensembl:ENSP00000352676 intact:EBI-310559|uniprotkb:Q6P445|uniprotkb:Q86VJ1|uniprotkb:Q96F34|uniprotkb:Q9UFZ7|uniprotkb:D3DS86|ensembl:ENSP00000382269|ensembl:ENSP00000450697 psi-mi:zran1_human(display_long)|uniprotkb:Zinc finger Ran-binding domain-containing protein 1(gene name synonym)|uniprotkb:ZRANB1(gene name)|psi-mi:ZRANB1(display_short)|uniprotkb:TRABID(gene name synonym)|uniprotkb:TRAF-binding domain-containing protein(gene name synonym) psi-mi:hecd1_human(display_long)|uniprotkb:HECTD1(gene name)|psi-mi:HECTD1(display_short)|uniprotkb:KIAA1131(gene name synonym)|uniprotkb:HECT domain-containing protein 1(gene name synonym)|uniprotkb:E3 ligase for inhibin receptor(gene name synonym)|uniprotkb:EULIR(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase HECTD1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511131|imex:IM-12079-64 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_060050.2|ensembl:ENSG00000019995(gene)|ensembl:ENST00000359653(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016477"(cell migration)|go:"GO:0022604"(regulation of cell morphogenesis)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0035523"(protein K29-linked deubiquitination)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046872"(metal ion binding)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071947"(protein deubiquitination involved in ubiquitin-dependent protein catabolic process)|go:"GO:1990168"(protein K33-linked deubiquitination)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR003323(Ovarian tumour, otubain)|interpro:IPR036443|interpro:IPR041294|mint:Q9UGI0|rcsb pdb:3ZRH|rcsb pdb:5AF6|reactome:R-HSA-195253|reactome:R-HSA-5689896|refseq:XP_005269983.1|dip:DIP-33806N|refseq:XP_016871846.1 ensembl:ENSG00000092148(gene)|ensembl:ENST00000399332(transcript)|ensembl:ENST00000553700(transcript)|go:"GO:0001779"(natural killer cell differentiation)|go:"GO:0001843"(neural tube closure)|go:"GO:0003170"(heart valve development)|go:"GO:0003281"(ventricular septum development)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0035904"(aorta development)|go:"GO:0046872"(metal ion binding)|go:"GO:0048856"(anatomical structure development)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0060707"(trophoblast giant cell differentiation)|go:"GO:0060708"(spongiotrophoblast differentiation)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|interpro:IPR000569(HECT)|interpro:IPR002110(Ankyrin)|interpro:IPR008979(Galactose-binding like)|interpro:IPR010606(Mib-herc2)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR012919(Sad1/UNC-like, C-terminal)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR020683|interpro:IPR035983|interpro:IPR036770|interpro:IPR037252|interpro:IPR041200|mint:Q9ULT8|rcsb pdb:2DK3|rcsb pdb:3DKM|reactome:R-HSA-983168|rcsb pdb:2LC3|refseq:XP_005267559.2|ensembl:ENSP00000382269|ensembl:ENSP00000450697|refseq:NP_056197.3|dip:DIP-31669N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:/cHOFsN7yB+8MUyL3cAG1v5MUAc9606 rogid:/l60ZSm+P4Vlc8B79wS7+T1Zvzk9606 intact-crc:09F497E50CE2A114|rigid:vXGijXmDoDuwBohm+6YJ5/+/cm0 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UGI0 uniprotkb:Q13033 intact:EBI-527853|uniprotkb:Q5SQP6|uniprotkb:B4DZ98|uniprotkb:Q69YK3|uniprotkb:D3DRF4|ensembl:ENSP00000352676 intact:EBI-1053857|uniprotkb:Q9NRA5|uniprotkb:A6NHZ7|uniprotkb:A2RTX7|ensembl:ENSP00000350071 psi-mi:zran1_human(display_long)|uniprotkb:Zinc finger Ran-binding domain-containing protein 1(gene name synonym)|uniprotkb:ZRANB1(gene name)|psi-mi:ZRANB1(display_short)|uniprotkb:TRABID(gene name synonym)|uniprotkb:TRAF-binding domain-containing protein(gene name synonym) psi-mi:strn3_human(display_long)|uniprotkb:Cell cycle autoantigen SG2NA(gene name synonym)|uniprotkb:S/G2 antigen(gene name synonym)|uniprotkb:STRN3(gene name)|psi-mi:STRN3(display_short)|uniprotkb:GS2NA(gene name synonym)|uniprotkb:SG2NA(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511131|imex:IM-12079-64 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_060050.2|ensembl:ENSG00000019995(gene)|ensembl:ENST00000359653(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016477"(cell migration)|go:"GO:0022604"(regulation of cell morphogenesis)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0035523"(protein K29-linked deubiquitination)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046872"(metal ion binding)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071947"(protein deubiquitination involved in ubiquitin-dependent protein catabolic process)|go:"GO:1990168"(protein K33-linked deubiquitination)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR003323(Ovarian tumour, otubain)|interpro:IPR036443|interpro:IPR041294|mint:Q9UGI0|rcsb pdb:3ZRH|rcsb pdb:5AF6|reactome:R-HSA-195253|reactome:R-HSA-5689896|refseq:XP_005269983.1|dip:DIP-33806N|refseq:XP_016871846.1 refseq:NP_001077362.1|refseq:NP_055389.3|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0070016"(armadillo repeat domain binding)|go:"GO:0090443"(FAR/SIN/STRIPAK complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR013258(Striatin, N-terminal)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|mint:Q13033|rcsb pdb:4N6J|rcsb pdb:6AKL|rcsb pdb:6IUR|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|rcsb pdb:7K36|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033147"(negative regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|ensembl:ENSG00000196792(gene)|ensembl:ENST00000357479(transcript) psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:/cHOFsN7yB+8MUyL3cAG1v5MUAc9606 rogid:gGqyj/yXjaB436zEu/pEoPzhnRQ9606 intact-crc:09F497E50CE2A114|rigid:vXGijXmDoDuwBohm+6YJ5/+/cm0 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UGI0 uniprotkb:Q8TD16 intact:EBI-527853|uniprotkb:Q5SQP6|uniprotkb:B4DZ98|uniprotkb:Q69YK3|uniprotkb:D3DRF4|ensembl:ENSP00000352676 intact:EBI-2372628|uniprotkb:O75181|uniprotkb:Q5TBQ2|uniprotkb:Q5TBQ3|uniprotkb:Q96LH2|uniprotkb:Q9BT84|uniprotkb:Q9H561|ensembl:ENSP00000364662 psi-mi:zran1_human(display_long)|uniprotkb:Zinc finger Ran-binding domain-containing protein 1(gene name synonym)|uniprotkb:ZRANB1(gene name)|psi-mi:ZRANB1(display_short)|uniprotkb:TRABID(gene name synonym)|uniprotkb:TRAF-binding domain-containing protein(gene name synonym) psi-mi:bicd2_human(display_long)|uniprotkb:BICD2(gene name)|psi-mi:BICD2(display_short)|uniprotkb:KIAA0699(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511131|imex:IM-12079-64 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_060050.2|ensembl:ENSG00000019995(gene)|ensembl:ENST00000359653(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016477"(cell migration)|go:"GO:0022604"(regulation of cell morphogenesis)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0035523"(protein K29-linked deubiquitination)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046872"(metal ion binding)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071947"(protein deubiquitination involved in ubiquitin-dependent protein catabolic process)|go:"GO:1990168"(protein K33-linked deubiquitination)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR003323(Ovarian tumour, otubain)|interpro:IPR036443|interpro:IPR041294|mint:Q9UGI0|rcsb pdb:3ZRH|rcsb pdb:5AF6|reactome:R-HSA-195253|reactome:R-HSA-5689896|refseq:XP_005269983.1|dip:DIP-33806N|refseq:XP_016871846.1 refseq:NP_001003800.1|refseq:NP_056065.1|dip:DIP-53426N|ensembl:ENSG00000185963(gene)|ensembl:ENST00000375512(transcript)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005642"(annulate lamellae)|go:"GO:0005643"(nuclear pore)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0008093"(cytoskeletal anchor activity)|go:"GO:0015031"(protein transport)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0034067"(protein localization to Golgi apparatus)|go:"GO:0034452"(dynactin binding)|go:"GO:0051028"(mRNA transport)|go:"GO:0051642"(centrosome localization)|go:"GO:0051959"(dynein light intermediate chain binding)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0070840"(dynein complex binding)|go:"GO:0072385"(minus-end-directed organelle transport along microtubule)|go:"GO:0072393"(microtubule anchoring at microtubule organizing center)|interpro:IPR018477|rcsb pdb:6OFP|rcsb pdb:6PSE|reactome:R-HSA-6811436 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:/cHOFsN7yB+8MUyL3cAG1v5MUAc9606 rogid:6MPNarWaiURuFhlX154W5E/1kpM9606 intact-crc:09F497E50CE2A114|rigid:vXGijXmDoDuwBohm+6YJ5/+/cm0 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UGI0 uniprotkb:Q14BN4 intact:EBI-527853|uniprotkb:Q5SQP6|uniprotkb:B4DZ98|uniprotkb:Q69YK3|uniprotkb:D3DRF4|ensembl:ENSP00000352676 intact:EBI-1043216|ensembl:ENSP00000499241|uniprotkb:Q14C95|uniprotkb:Q6AI54|uniprotkb:Q6UXC9|uniprotkb:Q6ZVQ8|uniprotkb:Q8NCW9|uniprotkb:Q9H297|uniprotkb:Q9HCH1|uniprotkb:Q9Y681 psi-mi:zran1_human(display_long)|uniprotkb:Zinc finger Ran-binding domain-containing protein 1(gene name synonym)|uniprotkb:ZRANB1(gene name)|psi-mi:ZRANB1(display_short)|uniprotkb:TRABID(gene name synonym)|uniprotkb:TRAF-binding domain-containing protein(gene name synonym) psi-mi:slmap_human(display_long)|uniprotkb:SLMAP(gene name)|psi-mi:SLMAP(display_short)|uniprotkb:KIAA1601(gene name synonym)|uniprotkb:SLAP(gene name synonym)|uniprotkb:UNQ1847/PRO3577(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511131|imex:IM-12079-64 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_060050.2|ensembl:ENSG00000019995(gene)|ensembl:ENST00000359653(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016477"(cell migration)|go:"GO:0022604"(regulation of cell morphogenesis)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0035523"(protein K29-linked deubiquitination)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046872"(metal ion binding)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071947"(protein deubiquitination involved in ubiquitin-dependent protein catabolic process)|go:"GO:1990168"(protein K33-linked deubiquitination)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR003323(Ovarian tumour, otubain)|interpro:IPR036443|interpro:IPR041294|mint:Q9UGI0|rcsb pdb:3ZRH|rcsb pdb:5AF6|reactome:R-HSA-195253|reactome:R-HSA-5689896|refseq:XP_005269983.1|dip:DIP-33806N|refseq:XP_016871846.1 ensembl:ENSG00000163681(gene)|ensembl:ENST00000659705(transcript)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006936"(muscle contraction)|go:"GO:0042383"(sarcolemma)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:1900825"(regulation of membrane depolarization during cardiac muscle cell action potential)|go:"GO:1902305"(regulation of sodium ion transmembrane transport)|go:"GO:1905150"(regulation of voltage-gated sodium channel activity)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR030498|rcsb pdb:6AKM|rcsb pdb:6AR0|rcsb pdb:6AR2|refseq:XP_016862659.1|refseq:NP_009090.2|refseq:NP_001298107.1|refseq:NP_001298108.1|refseq:NP_001291349.1|refseq:NP_001291350.1|refseq:XP_005265518.1|refseq:XP_005265523.1|refseq:XP_005265528.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:/cHOFsN7yB+8MUyL3cAG1v5MUAc9606 rogid:K73SyLNTT+WZ/eE6gcjXw6yiOXQ9606 intact-crc:09F497E50CE2A114|rigid:vXGijXmDoDuwBohm+6YJ5/+/cm0 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UGI0 uniprotkb:Q9NRL3 intact:EBI-527853|uniprotkb:Q5SQP6|uniprotkb:B4DZ98|uniprotkb:Q69YK3|uniprotkb:D3DRF4|ensembl:ENSP00000352676 intact:EBI-717245|intact:EBI-1058338|uniprotkb:Q8NE53|uniprotkb:A0A024R0V2|uniprotkb:B4DQH7|uniprotkb:F8VYA6|ensembl:ENSP00000263280 psi-mi:zran1_human(display_long)|uniprotkb:Zinc finger Ran-binding domain-containing protein 1(gene name synonym)|uniprotkb:ZRANB1(gene name)|psi-mi:ZRANB1(display_short)|uniprotkb:TRABID(gene name synonym)|uniprotkb:TRAF-binding domain-containing protein(gene name synonym) psi-mi:strn4_human(display_long)|uniprotkb:Zinedin(gene name synonym)|uniprotkb:STRN4(gene name)|psi-mi:STRN4(display_short)|uniprotkb:ZIN(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511131|imex:IM-12079-64 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_060050.2|ensembl:ENSG00000019995(gene)|ensembl:ENST00000359653(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016477"(cell migration)|go:"GO:0022604"(regulation of cell morphogenesis)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0035523"(protein K29-linked deubiquitination)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046872"(metal ion binding)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071947"(protein deubiquitination involved in ubiquitin-dependent protein catabolic process)|go:"GO:1990168"(protein K33-linked deubiquitination)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR003323(Ovarian tumour, otubain)|interpro:IPR036443|interpro:IPR041294|mint:Q9UGI0|rcsb pdb:3ZRH|rcsb pdb:5AF6|reactome:R-HSA-195253|reactome:R-HSA-5689896|refseq:XP_005269983.1|dip:DIP-33806N|refseq:XP_016871846.1 refseq:NP_001034966.1|refseq:NP_037535.2|ensembl:ENSG00000090372(gene)|ensembl:ENST00000263280(transcript)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0016020"(membrane)|go:"GO:0030425"(dendrite)|go:"GO:0043197"(dendritic spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0070016"(armadillo repeat domain binding)|go:"GO:0090443"(FAR/SIN/STRIPAK complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR013258(Striatin, N-terminal)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|mint:Q9NRL3 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:/cHOFsN7yB+8MUyL3cAG1v5MUAc9606 rogid:bgxVT2XfIqKPoGoN0sapQOnwfxw9606 intact-crc:09F497E50CE2A114|rigid:vXGijXmDoDuwBohm+6YJ5/+/cm0 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H078 uniprotkb:P15374 intact:EBI-2107221|uniprotkb:Q8ND11|uniprotkb:Q9H8Y0|uniprotkb:B4DXW4|uniprotkb:B4DXJ7|uniprotkb:B4DXP7|uniprotkb:E7EWN6|uniprotkb:F8W7P6|ensembl:ENSP00000294053 intact:EBI-954554|uniprotkb:Q5TBK8|uniprotkb:Q6IBE9|ensembl:ENSP00000366819|uniprotkb:B2R970 psi-mi:clpb_human(display_long)|uniprotkb:CLPB(gene name)|psi-mi:CLPB(display_short)|uniprotkb:HSP78(gene name synonym)|uniprotkb:SKD3(gene name synonym)|uniprotkb:Suppressor of potassium transport defect 3(gene name synonym) psi-mi:uchl3_human(display_long)|uniprotkb:Ubiquitin thioesterase L3(gene name synonym)|uniprotkb:UCHL3(gene name)|psi-mi:UCHL3(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511200|imex:IM-12079-65 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_110440.1|refseq:NP_001245321.1|refseq:NP_001245322.1|refseq:NP_001245323.1|ensembl:ENSG00000162129(gene)|ensembl:ENST00000294053(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0034605"(cellular response to heat)|go:"GO:0039529"(RIG-I signaling pathway)|go:"GO:0140374"(antiviral innate immune response)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001270(Chaperonin clpA/B)|interpro:IPR002110(Ankyrin)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR019489|interpro:IPR020683|interpro:IPR027417|interpro:IPR036770|mint:Q9H078 refseq:NP_001257881.1|refseq:NP_005993.1|ensembl:ENSG00000118939(gene)|ensembl:ENST00000377595(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008233"(peptidase activity)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019784"(NEDD8-specific protease activity)|go:"GO:0030163"(protein catabolic process)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043687"(post-translational protein modification)|interpro:IPR001578(Peptidase C12, ubiquitin carboxyl-terminal hydrolase 1)|interpro:IPR036959|interpro:IPR038765|rcsb pdb:1UCH|rcsb pdb:1XD3|rcsb pdb:6ISU|rcsb pdb:6QML|reactome:R-HSA-5689603|reactome:R-HSA-8866652|reactome:R-HSA-8951664|dip:DIP-29135N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:QqIOYOITwDC+c8kKtMGBHa/0Tjk9606 rogid:cPnctBpxrgvBKBSaQmhCsyd2nRM9606 intact-crc:C1AF6B2A70E6E2F2|rigid:aJJJ8oSpLi05ZsatSHGMrFm04qA false - ha tag:n-n|flag tag:n-n - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P09936 uniprotkb:Q04695 intact:EBI-714860|uniprotkb:Q71UM0|intact:EBI-1049220|uniprotkb:Q4W5K6|ensembl:ENSP00000284440|ensembl:ENSP00000422542 intact:EBI-297873|ensembl:ENSP00000308452|uniprotkb:A5Z1M9|uniprotkb:A5Z1N0|uniprotkb:A5Z1N1|uniprotkb:A5Z1N2|uniprotkb:A6NDV6|uniprotkb:A6NKQ2|uniprotkb:Q6IP98|uniprotkb:Q8N1P6 psi-mi:uchl1_human(display_long)|uniprotkb:Ubiquitin thioesterase L1(gene name synonym)|uniprotkb:Neuron cytoplasmic protein 9.5(gene name synonym)|uniprotkb:PGP 9.5(gene name synonym)|uniprotkb:UCHL1(gene name)|psi-mi:UCHL1(display_short) psi-mi:k1c17_human(display_long)|uniprotkb:KRT17(gene name)|psi-mi:KRT17(display_short)|uniprotkb:Cytokeratin-17(gene name synonym)|uniprotkb:39.1(gene name synonym)|uniprotkb:Keratin-17(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511186|imex:IM-12079-14 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004172.2|ensembl:ENSG00000154277(gene)|ensembl:ENST00000284440(transcript)|ensembl:ENST00000503431(transcript)|go:"GO:0002931"(response to ischemia)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0007412"(axon target recognition)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008242"(omega peptidase activity)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0016874"(ligase activity)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019896"(axonal transport of mitochondrion)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031694"(alpha-2A adrenergic receptor binding)|go:"GO:0035690"|go:"GO:0042755"(eating behavior)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0050905"(neuromuscular process)|go:"GO:1904115"(axon cytoplasm)|interpro:IPR001578(Peptidase C12, ubiquitin carboxyl-terminal hydrolase 1)|interpro:IPR030297|interpro:IPR036959|interpro:IPR038765|mint:P09936|rcsb pdb:2ETL|rcsb pdb:2LEN|rcsb pdb:3IFW|rcsb pdb:3IRT|rcsb pdb:3KVF|rcsb pdb:3KW5|rcsb pdb:4DM9|rcsb pdb:4JKJ|reactome:R-HSA-5689603|go:"GO:0055001"(muscle cell development)|dip:DIP-36620N ensembl:ENSG00000128422(gene)|ensembl:ENST00000311208(transcript)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005829"(cytosol)|go:"GO:0005882"(intermediate filament)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0031424"(keratinization)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0051798"(positive regulation of hair follicle development)|go:"GO:0071944"(cell periphery)|interpro:IPR002957(Keratin, type I)|interpro:IPR018039|interpro:IPR039008|mint:Q04695|reactome:R-HSA-6805567|reactome:R-HSA-6809371|refseq:NP_000413.1|dip:DIP-33093N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2020/03/02 rogid:bQ3cxdH+e5fTg7KZ1wjHcOd9cIs9606 rogid:cwKlvMqhQGUokThbIxgEkB6Wzxw9606 intact-crc:E42DA8984C9BB723|rigid:UkSoL7F86XgYUtvouLB3lEI+R7s false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P09936 uniprotkb:Q49A88 intact:EBI-714860|uniprotkb:Q71UM0|intact:EBI-1049220|uniprotkb:Q4W5K6|ensembl:ENSP00000284440|ensembl:ENSP00000422542 intact:EBI-751035|intact:EBI-2622203|intact:EBI-2858142|uniprotkb:B7Z2T2|uniprotkb:B8ZZ58|intact:EBI-946963|intact:EBI-1104778|uniprotkb:Q7Z3N3|uniprotkb:Q86T30|uniprotkb:Q8WUJ8|uniprotkb:Q96K47|uniprotkb:Q9H9A3|uniprotkb:Q9UFH0|uniprotkb:Q8IWF8|uniprotkb:B8ZZ41|uniprotkb:D3DN98|uniprotkb:B7Z2Q3 psi-mi:uchl1_human(display_long)|uniprotkb:Ubiquitin thioesterase L1(gene name synonym)|uniprotkb:Neuron cytoplasmic protein 9.5(gene name synonym)|uniprotkb:PGP 9.5(gene name synonym)|uniprotkb:UCHL1(gene name)|psi-mi:UCHL1(display_short) psi-mi:ccd14_human(display_long)|uniprotkb:CCDC14(gene name)|psi-mi:CCDC14(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511186|imex:IM-12079-14 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004172.2|ensembl:ENSG00000154277(gene)|ensembl:ENST00000284440(transcript)|ensembl:ENST00000503431(transcript)|go:"GO:0002931"(response to ischemia)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0007412"(axon target recognition)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008242"(omega peptidase activity)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0016874"(ligase activity)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019896"(axonal transport of mitochondrion)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031694"(alpha-2A adrenergic receptor binding)|go:"GO:0035690"|go:"GO:0042755"(eating behavior)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0050905"(neuromuscular process)|go:"GO:1904115"(axon cytoplasm)|interpro:IPR001578(Peptidase C12, ubiquitin carboxyl-terminal hydrolase 1)|interpro:IPR030297|interpro:IPR036959|interpro:IPR038765|mint:P09936|rcsb pdb:2ETL|rcsb pdb:2LEN|rcsb pdb:3IFW|rcsb pdb:3IRT|rcsb pdb:3KVF|rcsb pdb:3KW5|rcsb pdb:4DM9|rcsb pdb:4JKJ|reactome:R-HSA-5689603|go:"GO:0055001"(muscle cell development)|dip:DIP-36620N refseq:NP_073594.4|refseq:NP_001295246.1|refseq:XP_005247767.1|refseq:XP_005247768.1|refseq:XP_005247770.1|refseq:XP_005247771.1|refseq:XP_016862545.1|refseq:XP_016862547.1|refseq:XP_016862548.1|mint:Q49A88|dip:DIP-47727N|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0021762"(substantia nigra development)|go:"GO:0034451"(centriolar satellite)|go:"GO:0071539"(protein localization to centrosome)|interpro:IPR029343 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2020/03/02 rogid:bQ3cxdH+e5fTg7KZ1wjHcOd9cIs9606 rogid:y1bU4io/NA6LIX+pwRkB8gstVuY9606 intact-crc:E42DA8984C9BB723|rigid:UkSoL7F86XgYUtvouLB3lEI+R7s false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P09936 uniprotkb:P19013 intact:EBI-714860|uniprotkb:Q71UM0|intact:EBI-1049220|uniprotkb:Q4W5K6|ensembl:ENSP00000284440|ensembl:ENSP00000422542 intact:EBI-2371606|uniprotkb:Q6GTR8|uniprotkb:Q96LA7|uniprotkb:Q9BTL1|intact:EBI-22121113|uniprotkb:B4DRS2|uniprotkb:F8VS64|intact:EBI-22010019|intact:EBI-28973341|ensembl:ENSP00000448220 psi-mi:uchl1_human(display_long)|uniprotkb:Ubiquitin thioesterase L1(gene name synonym)|uniprotkb:Neuron cytoplasmic protein 9.5(gene name synonym)|uniprotkb:PGP 9.5(gene name synonym)|uniprotkb:UCHL1(gene name)|psi-mi:UCHL1(display_short) psi-mi:k2c4_human(display_long)|uniprotkb:KRT4(gene name)|psi-mi:KRT4(display_short)|uniprotkb:CYK4(gene name synonym)|uniprotkb:Cytokeratin-4(gene name synonym)|uniprotkb:Keratin-4(gene name synonym)|uniprotkb:Type-II keratin Kb4(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511186|imex:IM-12079-14 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004172.2|ensembl:ENSG00000154277(gene)|ensembl:ENST00000284440(transcript)|ensembl:ENST00000503431(transcript)|go:"GO:0002931"(response to ischemia)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0007412"(axon target recognition)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008242"(omega peptidase activity)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0016874"(ligase activity)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019896"(axonal transport of mitochondrion)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031694"(alpha-2A adrenergic receptor binding)|go:"GO:0035690"|go:"GO:0042755"(eating behavior)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0050905"(neuromuscular process)|go:"GO:1904115"(axon cytoplasm)|interpro:IPR001578(Peptidase C12, ubiquitin carboxyl-terminal hydrolase 1)|interpro:IPR030297|interpro:IPR036959|interpro:IPR038765|mint:P09936|rcsb pdb:2ETL|rcsb pdb:2LEN|rcsb pdb:3IFW|rcsb pdb:3IRT|rcsb pdb:3KVF|rcsb pdb:3KW5|rcsb pdb:4DM9|rcsb pdb:4JKJ|reactome:R-HSA-5689603|go:"GO:0055001"(muscle cell development)|dip:DIP-36620N ensembl:ENSP00000448220|refseq:NP_002263.3|ensembl:ENSG00000170477(gene)|ensembl:ENST00000551956(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005882"(intermediate filament)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0009986"(cell surface)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0045095"(keratin filament)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|interpro:IPR003054(Type II keratin)|interpro:IPR018039|interpro:IPR032444|interpro:IPR039008|mint:P19013|reactome:R-HSA-6805567|reactome:R-HSA-6809371 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2020/03/02 rogid:bQ3cxdH+e5fTg7KZ1wjHcOd9cIs9606 rogid:WBLRjdlqvNYbC7R2ZSNON6QLcOU9606 intact-crc:E42DA8984C9BB723|rigid:UkSoL7F86XgYUtvouLB3lEI+R7s false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y5K5 uniprotkb:P35998 intact:EBI-1051183|uniprotkb:Q5LJA6|uniprotkb:Q5LJA7|uniprotkb:Q8TBS4|uniprotkb:Q96BJ9|uniprotkb:Q9H1W5|uniprotkb:Q9P0I3|uniprotkb:Q9UQN2|ensembl:ENSP00000356425 intact:EBI-359710|uniprotkb:B7Z5E2|uniprotkb:A4D0Q1|uniprotkb:Q3LIA5|uniprotkb:Q9UDI3|ensembl:ENSP00000292644|ensembl:ENSP00000391211|ensembl:ENSP00000502939|ensembl:ENSP00000503179|ensembl:ENSP00000504608 psi-mi:uchl5_human(display_long)|uniprotkb:Ubiquitin thioesterase L5(gene name synonym)|uniprotkb:Ubiquitin C-terminal hydrolase UCH37(gene name synonym)|uniprotkb:UCHL5(gene name)|psi-mi:UCHL5(display_short)|uniprotkb:UCH37(gene name synonym)|uniprotkb:AD-019(orf name)|uniprotkb:CGI-70(orf name) psi-mi:prs7_human(display_long)|uniprotkb:PSMC2(gene name)|psi-mi:PSMC2(display_short)|uniprotkb:MSS1(gene name synonym)|uniprotkb:Proteasome 26S subunit ATPase 2(gene name synonym)|uniprotkb:Protein MSS1(gene name synonym)|uniprotkb:26S proteasome AAA-ATPase subunit RPT1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511218|imex:IM-12079-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001186190.1|refseq:NP_001186191.1|refseq:NP_001186192.1|refseq:NP_057068.1|ensembl:ENSG00000116750(gene)|ensembl:ENST00000367455(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0021670"(lateral ventricle development)|go:"GO:0030901"(midbrain development)|go:"GO:0031011"(Ino80 complex)|go:"GO:0031597"(cytosolic proteasome complex)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0048853"(forebrain morphogenesis)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070628"(proteasome binding)|interpro:IPR001578(Peptidase C12, ubiquitin carboxyl-terminal hydrolase 1)|interpro:IPR017390(Ubiquitinyl hydrolase, UCH37 type)|interpro:IPR033837|interpro:IPR036959|interpro:IPR038765|interpro:IPR041507|mint:Q9Y5K5|rcsb pdb:3A7S|rcsb pdb:3IHR|rcsb pdb:3RII|rcsb pdb:3RIS|rcsb pdb:3TB3|rcsb pdb:4UEL|rcsb pdb:4UEM|rcsb pdb:4UF5|rcsb pdb:4UF6|rcsb pdb:4WLP|reactome:R-HSA-2173788|reactome:R-HSA-5689603|dip:DIP-42671N refseq:NP_001191382.1|refseq:NP_002794.1|interpro:IPR005937(26S proteasome subunit P45)|interpro:IPR027417|interpro:IPR035245|interpro:IPR041569|mint:P35998|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4G|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|interpro:IPR003960(AAA ATPase, conserved site)|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VGZ|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHJ|rcsb pdb:5VHM|rcsb pdb:5VHN|rcsb pdb:5VHO|rcsb pdb:5VHP|ensembl:ENSG00000161057(gene)|ensembl:ENST00000292644(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|ensembl:ENST00000435765(transcript)|ensembl:ENST00000678493(transcript)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0016020"(membrane)|ensembl:ENST00000679205(transcript)|ensembl:ENST00000679341(transcript)|go:"GO:0017025"(TBP-class protein binding)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0036402"(proteasome-activating activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0000502"(proteasome complex)|go:"GO:0000932"(P-body)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0043197"(dendritic spine)|go:"GO:0045899"(positive regulation of RNA polymerase II transcription preinitiation complex assembly)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|rcsb pdb:5VHR|rcsb pdb:5VHS|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|rcsb pdb:5VHQ|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|reactome:R-HSA-5610780|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|dip:DIP-27554N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:gRm5ttq5Tc0cBIOQ1ut2ugzbMTY9606 rogid:ahQfjPKywP5DWNq3FB5XCjuqkJ09606 intact-crc:8048E4F3002361C1|rigid:5TE1CyyNtrgsGHuW/ZDbdWfMAUQ false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y5K5 uniprotkb:P55036 intact:EBI-1051183|uniprotkb:Q5LJA6|uniprotkb:Q5LJA7|uniprotkb:Q8TBS4|uniprotkb:Q96BJ9|uniprotkb:Q9H1W5|uniprotkb:Q9P0I3|uniprotkb:Q9UQN2|ensembl:ENSP00000356425 intact:EBI-359318|uniprotkb:Q5VWC5|uniprotkb:Q9NS92|uniprotkb:D3DV16|ensembl:ENSP00000357879 psi-mi:uchl5_human(display_long)|uniprotkb:Ubiquitin thioesterase L5(gene name synonym)|uniprotkb:Ubiquitin C-terminal hydrolase UCH37(gene name synonym)|uniprotkb:UCHL5(gene name)|psi-mi:UCHL5(display_short)|uniprotkb:UCH37(gene name synonym)|uniprotkb:AD-019(orf name)|uniprotkb:CGI-70(orf name) psi-mi:psmd4_human(display_long)|uniprotkb:PSMD4(gene name)|psi-mi:PSMD4(display_short)|uniprotkb:MCB1(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S5A(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN10(gene name synonym)|uniprotkb:Multiubiquitin chain-binding protein(gene name synonym)|uniprotkb:Antisecretory factor 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511218|imex:IM-12079-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001186190.1|refseq:NP_001186191.1|refseq:NP_001186192.1|refseq:NP_057068.1|ensembl:ENSG00000116750(gene)|ensembl:ENST00000367455(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0021670"(lateral ventricle development)|go:"GO:0030901"(midbrain development)|go:"GO:0031011"(Ino80 complex)|go:"GO:0031597"(cytosolic proteasome complex)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0048853"(forebrain morphogenesis)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070628"(proteasome binding)|interpro:IPR001578(Peptidase C12, ubiquitin carboxyl-terminal hydrolase 1)|interpro:IPR017390(Ubiquitinyl hydrolase, UCH37 type)|interpro:IPR033837|interpro:IPR036959|interpro:IPR038765|interpro:IPR041507|mint:Q9Y5K5|rcsb pdb:3A7S|rcsb pdb:3IHR|rcsb pdb:3RII|rcsb pdb:3RIS|rcsb pdb:3TB3|rcsb pdb:4UEL|rcsb pdb:4UEM|rcsb pdb:4UF5|rcsb pdb:4UF6|rcsb pdb:4WLP|reactome:R-HSA-2173788|reactome:R-HSA-5689603|dip:DIP-42671N refseq:NP_002801.1|dip:DIP-38189N|ensembl:ENSG00000159352(gene)|ensembl:ENST00000368884(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043248"(proteasome assembly)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR036465|mint:P55036|rcsb pdb:1P9C|rcsb pdb:1P9D|rcsb pdb:1UEL|rcsb pdb:1YX4|rcsb pdb:1YX5|rcsb pdb:1YX6|rcsb pdb:2KDE|rcsb pdb:2KDF|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VGZ|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHS|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6MUN|rcsb pdb:6U19|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:gRm5ttq5Tc0cBIOQ1ut2ugzbMTY9606 rogid:FTJG3ns3Ag/Y3xP3yEydGxppRcA9606 intact-crc:8048E4F3002361C1|rigid:5TE1CyyNtrgsGHuW/ZDbdWfMAUQ false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y5K5 uniprotkb:P17980 intact:EBI-1051183|uniprotkb:Q5LJA6|uniprotkb:Q5LJA7|uniprotkb:Q8TBS4|uniprotkb:Q96BJ9|uniprotkb:Q9H1W5|uniprotkb:Q9P0I3|uniprotkb:Q9UQN2|ensembl:ENSP00000356425 intact:EBI-359720|uniprotkb:Q3B757|ensembl:ENSP00000298852|ensembl:ENSP00000481029|uniprotkb:Q3B865|uniprotkb:Q53HU5|uniprotkb:Q6GPG8|uniprotkb:Q6IBS1|uniprotkb:Q96HD3|uniprotkb:B2R8V1 psi-mi:uchl5_human(display_long)|uniprotkb:Ubiquitin thioesterase L5(gene name synonym)|uniprotkb:Ubiquitin C-terminal hydrolase UCH37(gene name synonym)|uniprotkb:UCHL5(gene name)|psi-mi:UCHL5(display_short)|uniprotkb:UCH37(gene name synonym)|uniprotkb:AD-019(orf name)|uniprotkb:CGI-70(orf name) psi-mi:prs6a_human(display_long)|uniprotkb:PSMC3(gene name)|psi-mi:PSMC3(display_short)|uniprotkb:TBP1(gene name synonym)|uniprotkb:Proteasome 26S subunit ATPase 3(gene name synonym)|uniprotkb:Tat-binding protein 1(gene name synonym)|uniprotkb:Proteasome subunit P50(gene name synonym)|uniprotkb:26S proteasome AAA-ATPase subunit RPT5(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511218|imex:IM-12079-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001186190.1|refseq:NP_001186191.1|refseq:NP_001186192.1|refseq:NP_057068.1|ensembl:ENSG00000116750(gene)|ensembl:ENST00000367455(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0021670"(lateral ventricle development)|go:"GO:0030901"(midbrain development)|go:"GO:0031011"(Ino80 complex)|go:"GO:0031597"(cytosolic proteasome complex)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0048853"(forebrain morphogenesis)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070628"(proteasome binding)|interpro:IPR001578(Peptidase C12, ubiquitin carboxyl-terminal hydrolase 1)|interpro:IPR017390(Ubiquitinyl hydrolase, UCH37 type)|interpro:IPR033837|interpro:IPR036959|interpro:IPR038765|interpro:IPR041507|mint:Q9Y5K5|rcsb pdb:3A7S|rcsb pdb:3IHR|rcsb pdb:3RII|rcsb pdb:3RIS|rcsb pdb:3TB3|rcsb pdb:4UEL|rcsb pdb:4UEM|rcsb pdb:4UF5|rcsb pdb:4UF6|rcsb pdb:4WLP|reactome:R-HSA-2173788|reactome:R-HSA-5689603|dip:DIP-42671N refseq:NP_002795.2|ensembl:ENSG00000165916(gene)|ensembl:ENST00000298852(transcript)|ensembl:ENST00000619920(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0000932"(P-body)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0030163"(protein catabolic process)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042802"(identical protein binding)|go:"GO:0043921"(modulation by host of viral transcription)|go:"GO:0045899"(positive regulation of RNA polymerase II transcription preinitiation complex assembly)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR005937(26S proteasome subunit P45)|interpro:IPR027417|interpro:IPR032501|interpro:IPR035254|interpro:IPR041569|mint:P17980|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4G|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VGZ|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHJ|rcsb pdb:5VHM|rcsb pdb:5VHN|rcsb pdb:5VHO|rcsb pdb:5VHP|rcsb pdb:5VHQ|rcsb pdb:5VHR|rcsb pdb:5VHS|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6WJD|rcsb pdb:6WJN|go:"GO:0036402"(proteasome-activating activity)|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-1236978|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|dip:DIP-27555N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:gRm5ttq5Tc0cBIOQ1ut2ugzbMTY9606 rogid:CejeauChmqeXNwBYF2cPz7mgMuw9606 intact-crc:8048E4F3002361C1|rigid:5TE1CyyNtrgsGHuW/ZDbdWfMAUQ false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y5K5 uniprotkb:P54578 intact:EBI-1051183|uniprotkb:Q5LJA6|uniprotkb:Q5LJA7|uniprotkb:Q8TBS4|uniprotkb:Q96BJ9|uniprotkb:Q9H1W5|uniprotkb:Q9P0I3|uniprotkb:Q9UQN2|ensembl:ENSP00000356425 intact:EBI-1048016|uniprotkb:Q53XY5|uniprotkb:B7Z4N8|uniprotkb:J3QRZ5|ensembl:ENSP00000261601 psi-mi:uchl5_human(display_long)|uniprotkb:Ubiquitin thioesterase L5(gene name synonym)|uniprotkb:Ubiquitin C-terminal hydrolase UCH37(gene name synonym)|uniprotkb:UCHL5(gene name)|psi-mi:UCHL5(display_short)|uniprotkb:UCH37(gene name synonym)|uniprotkb:AD-019(orf name)|uniprotkb:CGI-70(orf name) psi-mi:ubp14_human(display_long)|uniprotkb:USP14(gene name)|psi-mi:USP14(display_short)|uniprotkb:TGT(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 14(gene name synonym)|uniprotkb:Deubiquitinating enzyme 14(gene name synonym)|uniprotkb:Ubiquitin thioesterase 14(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511218|imex:IM-12079-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001186190.1|refseq:NP_001186191.1|refseq:NP_001186192.1|refseq:NP_057068.1|ensembl:ENSG00000116750(gene)|ensembl:ENST00000367455(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0021670"(lateral ventricle development)|go:"GO:0030901"(midbrain development)|go:"GO:0031011"(Ino80 complex)|go:"GO:0031597"(cytosolic proteasome complex)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0048853"(forebrain morphogenesis)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070628"(proteasome binding)|interpro:IPR001578(Peptidase C12, ubiquitin carboxyl-terminal hydrolase 1)|interpro:IPR017390(Ubiquitinyl hydrolase, UCH37 type)|interpro:IPR033837|interpro:IPR036959|interpro:IPR038765|interpro:IPR041507|mint:Q9Y5K5|rcsb pdb:3A7S|rcsb pdb:3IHR|rcsb pdb:3RII|rcsb pdb:3RIS|rcsb pdb:3TB3|rcsb pdb:4UEL|rcsb pdb:4UEM|rcsb pdb:4UF5|rcsb pdb:4UF6|rcsb pdb:4WLP|reactome:R-HSA-2173788|reactome:R-HSA-5689603|dip:DIP-42671N refseq:NP_001032411.1|refseq:NP_005142.1|ensembl:ENSG00000101557(gene)|ensembl:ENST00000261601(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0050920"(regulation of chemotaxis)|go:"GO:0045087"(innate immune response)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903070"(negative regulation of ER-associated ubiquitin-dependent protein catabolic process)|interpro:IPR000626(Ubiquitin)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR019954|interpro:IPR028889|interpro:IPR029071|interpro:IPR038765|interpro:IPR044635|mint:P54578|rcsb pdb:2AYN|rcsb pdb:2AYO|rcsb pdb:5GJQ|rcsb pdb:6IIK|rcsb pdb:6IIL|rcsb pdb:6IIM|rcsb pdb:6IIN|rcsb pdb:6LVS|reactome:R-HSA-5689880|go:"GO:0070628"(proteasome binding) psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:gRm5ttq5Tc0cBIOQ1ut2ugzbMTY9606 rogid:5hXfHmHds5nuvdlFYWoB/G6nvmk9606 intact-crc:8048E4F3002361C1|rigid:5TE1CyyNtrgsGHuW/ZDbdWfMAUQ false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y5K5 uniprotkb:Q15008 intact:EBI-1051183|uniprotkb:Q5LJA6|uniprotkb:Q5LJA7|uniprotkb:Q8TBS4|uniprotkb:Q96BJ9|uniprotkb:Q9H1W5|uniprotkb:Q9P0I3|uniprotkb:Q9UQN2|ensembl:ENSP00000356425 intact:EBI-359701|uniprotkb:E9PHI9|uniprotkb:A8K2E0|ensembl:ENSP00000295901|uniprotkb:Q6UV22 psi-mi:uchl5_human(display_long)|uniprotkb:Ubiquitin thioesterase L5(gene name synonym)|uniprotkb:Ubiquitin C-terminal hydrolase UCH37(gene name synonym)|uniprotkb:UCHL5(gene name)|psi-mi:UCHL5(display_short)|uniprotkb:UCH37(gene name synonym)|uniprotkb:AD-019(orf name)|uniprotkb:CGI-70(orf name) psi-mi:psmd6_human(display_long)|uniprotkb:PSMD6(gene name)|psi-mi:PSMD6(display_short)|uniprotkb:KIAA0107(gene name synonym)|uniprotkb:PFAAP4(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S10(gene name synonym)|uniprotkb:p42A(gene name synonym)|uniprotkb:Proteasome regulatory particle subunit p44S10(gene name synonym)|uniprotkb:Phosphonoformate immuno-associated protein 4(gene name synonym)|uniprotkb:Breast cancer-associated protein SGA-113M(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN7(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511218|imex:IM-12079-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001186190.1|refseq:NP_001186191.1|refseq:NP_001186192.1|refseq:NP_057068.1|ensembl:ENSG00000116750(gene)|ensembl:ENST00000367455(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0021670"(lateral ventricle development)|go:"GO:0030901"(midbrain development)|go:"GO:0031011"(Ino80 complex)|go:"GO:0031597"(cytosolic proteasome complex)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0048853"(forebrain morphogenesis)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070628"(proteasome binding)|interpro:IPR001578(Peptidase C12, ubiquitin carboxyl-terminal hydrolase 1)|interpro:IPR017390(Ubiquitinyl hydrolase, UCH37 type)|interpro:IPR033837|interpro:IPR036959|interpro:IPR038765|interpro:IPR041507|mint:Q9Y5K5|rcsb pdb:3A7S|rcsb pdb:3IHR|rcsb pdb:3RII|rcsb pdb:3RIS|rcsb pdb:3TB3|rcsb pdb:4UEL|rcsb pdb:4UEM|rcsb pdb:4UF5|rcsb pdb:4UF6|rcsb pdb:4WLP|reactome:R-HSA-2173788|reactome:R-HSA-5689603|dip:DIP-42671N refseq:NP_055629.1|ensembl:ENSG00000163636(gene)|ensembl:ENST00000295901(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019585|interpro:IPR035268|interpro:IPR036390|mint:Q15008|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VGZ|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHS|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSG|rcsb pdb:6MSH|reactome:R-HSA-5358346|reactome:R-HSA-1236978|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-1236974|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|reactome:R-HSA-69601|reactome:R-HSA-69481|refseq:NP_001258708.1|refseq:NP_001258709.1|refseq:NP_001258710.1|dip:DIP-27590N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:gRm5ttq5Tc0cBIOQ1ut2ugzbMTY9606 rogid:ULOM02v6J56vZLlAGn7wN3N6Efw9606 intact-crc:8048E4F3002361C1|rigid:5TE1CyyNtrgsGHuW/ZDbdWfMAUQ false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y5K5 uniprotkb:P28072 intact:EBI-1051183|uniprotkb:Q5LJA6|uniprotkb:Q5LJA7|uniprotkb:Q8TBS4|uniprotkb:Q96BJ9|uniprotkb:Q9H1W5|uniprotkb:Q9P0I3|uniprotkb:Q9UQN2|ensembl:ENSP00000356425 intact:EBI-359288|uniprotkb:Q96J55|ensembl:ENSP00000270586 psi-mi:uchl5_human(display_long)|uniprotkb:Ubiquitin thioesterase L5(gene name synonym)|uniprotkb:Ubiquitin C-terminal hydrolase UCH37(gene name synonym)|uniprotkb:UCHL5(gene name)|psi-mi:UCHL5(display_short)|uniprotkb:UCH37(gene name synonym)|uniprotkb:AD-019(orf name)|uniprotkb:CGI-70(orf name) psi-mi:psb6_human(display_long)|uniprotkb:PSMB6(gene name)|psi-mi:PSMB6(display_short)|uniprotkb:LMPY(gene name synonym)|uniprotkb:Proteasome delta chain(gene name synonym)|uniprotkb:Macropain delta chain(gene name synonym)|uniprotkb:Multicatalytic endopeptidase complex delta chain(gene name synonym)|uniprotkb:Proteasome subunit Y(gene name synonym)|uniprotkb:Y(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511218|imex:IM-12079-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001186190.1|refseq:NP_001186191.1|refseq:NP_001186192.1|refseq:NP_057068.1|ensembl:ENSG00000116750(gene)|ensembl:ENST00000367455(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0021670"(lateral ventricle development)|go:"GO:0030901"(midbrain development)|go:"GO:0031011"(Ino80 complex)|go:"GO:0031597"(cytosolic proteasome complex)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0048853"(forebrain morphogenesis)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070628"(proteasome binding)|interpro:IPR001578(Peptidase C12, ubiquitin carboxyl-terminal hydrolase 1)|interpro:IPR017390(Ubiquitinyl hydrolase, UCH37 type)|interpro:IPR033837|interpro:IPR036959|interpro:IPR038765|interpro:IPR041507|mint:Q9Y5K5|rcsb pdb:3A7S|rcsb pdb:3IHR|rcsb pdb:3RII|rcsb pdb:3RIS|rcsb pdb:3TB3|rcsb pdb:4UEL|rcsb pdb:4UEM|rcsb pdb:4UF5|rcsb pdb:4UF6|rcsb pdb:4WLP|reactome:R-HSA-2173788|reactome:R-HSA-5689603|dip:DIP-42671N refseq:NP_002789.1|go:"GO:0005829"(cytosol)|go:"GO:0005839"(proteasome core complex)|go:"GO:0010499"(proteasomal ubiquitin-independent protein catabolic process)|go:"GO:0019774"(proteasome core complex, beta-subunit complex)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045296"(cadherin binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000243(Peptidase T1A, proteasome beta-subunit)|interpro:IPR001353(20S proteasome, A and B subunits)|interpro:IPR016050(Proteasome, beta-type subunit, conserved site)|interpro:IPR023333|interpro:IPR029055|interpro:IPR035140|mint:P28072|rcsb pdb:4R3O|rcsb pdb:4R67|rcsb pdb:5A0Q|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4G|rcsb pdb:5LE5|rcsb pdb:5LEX|rcsb pdb:5LEY|rcsb pdb:5LEZ|rcsb pdb:5LF0|rcsb pdb:5LF1|rcsb pdb:5LF3|rcsb pdb:5LF4|rcsb pdb:5LF6|rcsb pdb:5LF7|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFO|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:6KWY|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|go:"GO:0005737"(cytoplasm)|rcsb pdb:6R70|rcsb pdb:6REY|rcsb pdb:6RGQ|rcsb pdb:6WJD|rcsb pdb:6WJN|rcsb pdb:6XMJ|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|ensembl:ENSG00000142507(gene)|ensembl:ENST00000270586(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004298"(threonine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|dip:DIP-33847N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:gRm5ttq5Tc0cBIOQ1ut2ugzbMTY9606 rogid:4LRxYA6/tM2hsc96iP29c5J7ew49606 intact-crc:8048E4F3002361C1|rigid:5TE1CyyNtrgsGHuW/ZDbdWfMAUQ false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y5K5 uniprotkb:P17706 intact:EBI-1051183|uniprotkb:Q5LJA6|uniprotkb:Q5LJA7|uniprotkb:Q8TBS4|uniprotkb:Q96BJ9|uniprotkb:Q9H1W5|uniprotkb:Q9P0I3|uniprotkb:Q9UQN2|ensembl:ENSP00000356425 intact:EBI-984930|uniprotkb:K7ENG3|uniprotkb:Q96HR2|ensembl:ENSP00000311857|uniprotkb:A8MXU3|uniprotkb:Q96AU5|uniprotkb:A8K955 psi-mi:uchl5_human(display_long)|uniprotkb:Ubiquitin thioesterase L5(gene name synonym)|uniprotkb:Ubiquitin C-terminal hydrolase UCH37(gene name synonym)|uniprotkb:UCHL5(gene name)|psi-mi:UCHL5(display_short)|uniprotkb:UCH37(gene name synonym)|uniprotkb:AD-019(orf name)|uniprotkb:CGI-70(orf name) psi-mi:ptn2_human(display_long)|uniprotkb:T-cell protein-tyrosine phosphatase(gene name synonym)|uniprotkb:PTPN2(gene name)|psi-mi:PTPN2(display_short)|uniprotkb:PTPT(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511218|imex:IM-12079-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001186190.1|refseq:NP_001186191.1|refseq:NP_001186192.1|refseq:NP_057068.1|ensembl:ENSG00000116750(gene)|ensembl:ENST00000367455(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0021670"(lateral ventricle development)|go:"GO:0030901"(midbrain development)|go:"GO:0031011"(Ino80 complex)|go:"GO:0031597"(cytosolic proteasome complex)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0048853"(forebrain morphogenesis)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070628"(proteasome binding)|interpro:IPR001578(Peptidase C12, ubiquitin carboxyl-terminal hydrolase 1)|interpro:IPR017390(Ubiquitinyl hydrolase, UCH37 type)|interpro:IPR033837|interpro:IPR036959|interpro:IPR038765|interpro:IPR041507|mint:Q9Y5K5|rcsb pdb:3A7S|rcsb pdb:3IHR|rcsb pdb:3RII|rcsb pdb:3RIS|rcsb pdb:3TB3|rcsb pdb:4UEL|rcsb pdb:4UEM|rcsb pdb:4UF5|rcsb pdb:4UF6|rcsb pdb:4WLP|reactome:R-HSA-2173788|reactome:R-HSA-5689603|dip:DIP-42671N ensembl:ENSG00000175354(gene)|ensembl:ENST00000309660(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0004726"(non-membrane spanning protein tyrosine phosphatase activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010804"(negative regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0010888"(negative regulation of lipid storage)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019905"(syntaxin binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030217"(T cell differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042532"(negative regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0045650"(negative regulation of macrophage differentiation)|go:"GO:0045722"(positive regulation of gluconeogenesis)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0050922"(negative regulation of chemotaxis)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060336"(negative regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060339"(negative regulation of type I interferon-mediated signaling pathway)|go:"GO:0061099"(negative regulation of protein tyrosine kinase activity)|go:"GO:0070104"(negative regulation of interleukin-6-mediated signaling pathway)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0097677"(STAT family protein binding)|go:"GO:1902202"(regulation of hepatocyte growth factor receptor signaling pathway)|go:"GO:1902206"(negative regulation of interleukin-2-mediated signaling pathway)|go:"GO:1902215"(negative regulation of interleukin-4-mediated signaling pathway)|go:"GO:1902227"(negative regulation of macrophage colony-stimulating factor signaling pathway)|go:"GO:1902233"(negative regulation of positive thymic T cell selection)|go:"GO:1902237"(positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903899"(positive regulation of PERK-mediated unfolded protein response)|go:"GO:2000587"(negative regulation of platelet-derived growth factor receptor-beta signaling pathway)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR012265(Protein-tyrosine phosphatase, non-receptor type-1, -2)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|mint:P17706|rcsb pdb:1L8K|reactome:R-HSA-877312|reactome:R-HSA-9008059|reactome:R-HSA-6807004|refseq:NP_001193942.1|refseq:NP_002819.2|refseq:NP_536347.1|refseq:NP_536348.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:gRm5ttq5Tc0cBIOQ1ut2ugzbMTY9606 rogid:z8pewLjrIdVPp07u6Rz7xfyn76k9606 intact-crc:8048E4F3002361C1|rigid:5TE1CyyNtrgsGHuW/ZDbdWfMAUQ false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y5K5 uniprotkb:P49720 intact:EBI-1051183|uniprotkb:Q5LJA6|uniprotkb:Q5LJA7|uniprotkb:Q8TBS4|uniprotkb:Q96BJ9|uniprotkb:Q9H1W5|uniprotkb:Q9P0I3|uniprotkb:Q9UQN2|ensembl:ENSP00000356425 intact:EBI-603340|uniprotkb:P31147|uniprotkb:Q0P6J7|uniprotkb:Q96E27|ensembl:ENSP00000483688|ensembl:ENSP00000483956 psi-mi:uchl5_human(display_long)|uniprotkb:Ubiquitin thioesterase L5(gene name synonym)|uniprotkb:Ubiquitin C-terminal hydrolase UCH37(gene name synonym)|uniprotkb:UCHL5(gene name)|psi-mi:UCHL5(display_short)|uniprotkb:UCH37(gene name synonym)|uniprotkb:AD-019(orf name)|uniprotkb:CGI-70(orf name) psi-mi:psb3_human(display_long)|uniprotkb:PSMB3(gene name)|psi-mi:PSMB3(display_short)|uniprotkb:Proteasome theta chain(gene name synonym)|uniprotkb:Proteasome chain 13(gene name synonym)|uniprotkb:Proteasome component C10-II(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511218|imex:IM-12079-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001186190.1|refseq:NP_001186191.1|refseq:NP_001186192.1|refseq:NP_057068.1|ensembl:ENSG00000116750(gene)|ensembl:ENST00000367455(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0021670"(lateral ventricle development)|go:"GO:0030901"(midbrain development)|go:"GO:0031011"(Ino80 complex)|go:"GO:0031597"(cytosolic proteasome complex)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0048853"(forebrain morphogenesis)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070628"(proteasome binding)|interpro:IPR001578(Peptidase C12, ubiquitin carboxyl-terminal hydrolase 1)|interpro:IPR017390(Ubiquitinyl hydrolase, UCH37 type)|interpro:IPR033837|interpro:IPR036959|interpro:IPR038765|interpro:IPR041507|mint:Q9Y5K5|rcsb pdb:3A7S|rcsb pdb:3IHR|rcsb pdb:3RII|rcsb pdb:3RIS|rcsb pdb:3TB3|rcsb pdb:4UEL|rcsb pdb:4UEM|rcsb pdb:4UF5|rcsb pdb:4UF6|rcsb pdb:4WLP|reactome:R-HSA-2173788|reactome:R-HSA-5689603|dip:DIP-42671N refseq:NP_002786.2|dip:DIP-33846N|ensembl:ENSG00000275903(gene)|ensembl:ENSG00000277791(gene)|ensembl:ENST00000619426(transcript)|ensembl:ENST00000619951(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004298"(threonine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005839"(proteasome core complex)|go:"GO:0010499"(proteasomal ubiquitin-independent protein catabolic process)|go:"GO:0019774"(proteasome core complex, beta-subunit complex)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001353(20S proteasome, A and B subunits)|interpro:IPR016050(Proteasome, beta-type subunit, conserved site)|interpro:IPR023333|interpro:IPR029055|interpro:IPR033811|mint:P49720|rcsb pdb:4R3O|rcsb pdb:4R67|rcsb pdb:5A0Q|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4G|rcsb pdb:5LE5|rcsb pdb:5LEX|rcsb pdb:5LEY|rcsb pdb:5LEZ|rcsb pdb:5LF0|rcsb pdb:5LF1|rcsb pdb:5LF3|rcsb pdb:5LF4|rcsb pdb:5LF6|rcsb pdb:5LF7|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFO|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:6AVO|rcsb pdb:6E5B|rcsb pdb:6KWY|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6R70|rcsb pdb:6REY|rcsb pdb:6RGQ|rcsb pdb:6WJD|rcsb pdb:6WJN|rcsb pdb:6XMJ|rcsb pdb:7AWE|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:gRm5ttq5Tc0cBIOQ1ut2ugzbMTY9606 rogid:H4UDdXV1BaXHp6mEPafNy+Iv8389606 intact-crc:8048E4F3002361C1|rigid:5TE1CyyNtrgsGHuW/ZDbdWfMAUQ false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y5K5 uniprotkb:Q9Y6E3 intact:EBI-1051183|uniprotkb:Q5LJA6|uniprotkb:Q5LJA7|uniprotkb:Q8TBS4|uniprotkb:Q96BJ9|uniprotkb:Q9H1W5|uniprotkb:Q9P0I3|uniprotkb:Q9UQN2|ensembl:ENSP00000356425 intact:EBI-2510934 psi-mi:uchl5_human(display_long)|uniprotkb:Ubiquitin thioesterase L5(gene name synonym)|uniprotkb:Ubiquitin C-terminal hydrolase UCH37(gene name synonym)|uniprotkb:UCHL5(gene name)|psi-mi:UCHL5(display_short)|uniprotkb:UCH37(gene name synonym)|uniprotkb:AD-019(orf name)|uniprotkb:CGI-70(orf name) psi-mi:q9y6e3_human(display_long)|uniprotkb:26S proteasome regulatory subunit RPN9(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S11(gene name synonym)|uniprotkb:26S proteasome regulatory subunit p40.5(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511218|imex:IM-12079-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001186190.1|refseq:NP_001186191.1|refseq:NP_001186192.1|refseq:NP_057068.1|ensembl:ENSG00000116750(gene)|ensembl:ENST00000367455(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0021670"(lateral ventricle development)|go:"GO:0030901"(midbrain development)|go:"GO:0031011"(Ino80 complex)|go:"GO:0031597"(cytosolic proteasome complex)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0048853"(forebrain morphogenesis)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070628"(proteasome binding)|interpro:IPR001578(Peptidase C12, ubiquitin carboxyl-terminal hydrolase 1)|interpro:IPR017390(Ubiquitinyl hydrolase, UCH37 type)|interpro:IPR033837|interpro:IPR036959|interpro:IPR038765|interpro:IPR041507|mint:Q9Y5K5|rcsb pdb:3A7S|rcsb pdb:3IHR|rcsb pdb:3RII|rcsb pdb:3RIS|rcsb pdb:3TB3|rcsb pdb:4UEL|rcsb pdb:4UEM|rcsb pdb:4UF5|rcsb pdb:4UF6|rcsb pdb:4WLP|reactome:R-HSA-2173788|reactome:R-HSA-5689603|dip:DIP-42671N interpro:IPR000717(Proteasome component region PCI)|interpro:IPR035298|interpro:IPR036390 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:gRm5ttq5Tc0cBIOQ1ut2ugzbMTY9606 rogid:NKwKM9L5kXEuzLqTMQonYBVjAhg9606 intact-crc:8048E4F3002361C1|rigid:5TE1CyyNtrgsGHuW/ZDbdWfMAUQ false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y5K5 uniprotkb:Q9BRP4 intact:EBI-1051183|uniprotkb:Q5LJA6|uniprotkb:Q5LJA7|uniprotkb:Q8TBS4|uniprotkb:Q96BJ9|uniprotkb:Q9H1W5|uniprotkb:Q9P0I3|uniprotkb:Q9UQN2|ensembl:ENSP00000356425 intact:EBI-1056358|uniprotkb:A6NDR5|uniprotkb:Q4G165|uniprotkb:Q53HS9|uniprotkb:Q7Z500|uniprotkb:Q8TBU6|uniprotkb:Q9HAB6|uniprotkb:B4DPB0|uniprotkb:B7ZAS9|ensembl:ENSP00000311665 psi-mi:uchl5_human(display_long)|uniprotkb:Ubiquitin thioesterase L5(gene name synonym)|uniprotkb:Ubiquitin C-terminal hydrolase UCH37(gene name synonym)|uniprotkb:UCHL5(gene name)|psi-mi:UCHL5(display_short)|uniprotkb:UCH37(gene name synonym)|uniprotkb:AD-019(orf name)|uniprotkb:CGI-70(orf name) psi-mi:paaf1_human(display_long)|uniprotkb:PAAF1(gene name)|psi-mi:PAAF1(display_short)|uniprotkb:WDR71(gene name synonym)|uniprotkb:WD repeat-containing protein 71(gene name synonym)|uniprotkb:Protein G-16(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511218|imex:IM-12079-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001186190.1|refseq:NP_001186191.1|refseq:NP_001186192.1|refseq:NP_057068.1|ensembl:ENSG00000116750(gene)|ensembl:ENST00000367455(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0021670"(lateral ventricle development)|go:"GO:0030901"(midbrain development)|go:"GO:0031011"(Ino80 complex)|go:"GO:0031597"(cytosolic proteasome complex)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0048853"(forebrain morphogenesis)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070628"(proteasome binding)|interpro:IPR001578(Peptidase C12, ubiquitin carboxyl-terminal hydrolase 1)|interpro:IPR017390(Ubiquitinyl hydrolase, UCH37 type)|interpro:IPR033837|interpro:IPR036959|interpro:IPR038765|interpro:IPR041507|mint:Q9Y5K5|rcsb pdb:3A7S|rcsb pdb:3IHR|rcsb pdb:3RII|rcsb pdb:3RIS|rcsb pdb:3TB3|rcsb pdb:4UEL|rcsb pdb:4UEM|rcsb pdb:4UF5|rcsb pdb:4UF6|rcsb pdb:4WLP|reactome:R-HSA-2173788|reactome:R-HSA-5689603|dip:DIP-42671N refseq:NP_079431.1|refseq:NP_001254732.1|refseq:NP_001254733.1|refseq:NP_001254734.1|refseq:NP_001254735.1|ensembl:ENSG00000175575(gene)|ensembl:ENST00000310571(transcript)|go:"GO:0000502"(proteasome complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR020472|interpro:IPR036322|mint:Q9BRP4 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:gRm5ttq5Tc0cBIOQ1ut2ugzbMTY9606 rogid:n8MCo8uX9utRiBibnvT8pfXJLBc9606 intact-crc:8048E4F3002361C1|rigid:5TE1CyyNtrgsGHuW/ZDbdWfMAUQ false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y5K5 uniprotkb:Q8NBZ0 intact:EBI-1051183|uniprotkb:Q5LJA6|uniprotkb:Q5LJA7|uniprotkb:Q8TBS4|uniprotkb:Q96BJ9|uniprotkb:Q9H1W5|uniprotkb:Q9P0I3|uniprotkb:Q9UQN2|ensembl:ENSP00000356425 intact:EBI-769401|uniprotkb:Q6Y2K3|intact:EBI-28973946|ensembl:ENSP00000457016 psi-mi:uchl5_human(display_long)|uniprotkb:Ubiquitin thioesterase L5(gene name synonym)|uniprotkb:Ubiquitin C-terminal hydrolase UCH37(gene name synonym)|uniprotkb:UCHL5(gene name)|psi-mi:UCHL5(display_short)|uniprotkb:UCH37(gene name synonym)|uniprotkb:AD-019(orf name)|uniprotkb:CGI-70(orf name) psi-mi:in80e_human(display_long)|uniprotkb:CCDC95(gene name synonym)|uniprotkb:Coiled-coil domain-containing protein 95(gene name synonym)|uniprotkb:INO80E(gene name)|psi-mi:INO80E(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511218|imex:IM-12079-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001186190.1|refseq:NP_001186191.1|refseq:NP_001186192.1|refseq:NP_057068.1|ensembl:ENSG00000116750(gene)|ensembl:ENST00000367455(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0021670"(lateral ventricle development)|go:"GO:0030901"(midbrain development)|go:"GO:0031011"(Ino80 complex)|go:"GO:0031597"(cytosolic proteasome complex)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0048853"(forebrain morphogenesis)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070628"(proteasome binding)|interpro:IPR001578(Peptidase C12, ubiquitin carboxyl-terminal hydrolase 1)|interpro:IPR017390(Ubiquitinyl hydrolase, UCH37 type)|interpro:IPR033837|interpro:IPR036959|interpro:IPR038765|interpro:IPR041507|mint:Q9Y5K5|rcsb pdb:3A7S|rcsb pdb:3IHR|rcsb pdb:3RII|rcsb pdb:3RIS|rcsb pdb:3TB3|rcsb pdb:4UEL|rcsb pdb:4UEM|rcsb pdb:4UF5|rcsb pdb:4UF6|rcsb pdb:4WLP|reactome:R-HSA-2173788|reactome:R-HSA-5689603|dip:DIP-42671N refseq:NP_775889.1|ensembl:ENST00000562441|ensembl:ENSP00000456073|ensembl:ENSP00000457016|ensembl:ENST00000567065|ensembl:ENSP00000454665|ensembl:ENST00000620599|ensembl:ENSP00000484187|refseq:NP_001291491.1|refseq:NP_001291492.1|ensembl:ENSG00000169592(gene)|ensembl:ENST00000563197(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0031011"(Ino80 complex)|interpro:IPR026678|mint:Q8NBZ0|reactome:R-HSA-5689603|reactome:R-HSA-5696394 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:gRm5ttq5Tc0cBIOQ1ut2ugzbMTY9606 rogid:gGBXpYQkxY5mcF4I/4rTzjXZbG09606 intact-crc:8048E4F3002361C1|rigid:5TE1CyyNtrgsGHuW/ZDbdWfMAUQ false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y5K5 uniprotkb:O43396 intact:EBI-1051183|uniprotkb:Q5LJA6|uniprotkb:Q5LJA7|uniprotkb:Q8TBS4|uniprotkb:Q96BJ9|uniprotkb:Q9H1W5|uniprotkb:Q9P0I3|uniprotkb:Q9UQN2|ensembl:ENSP00000356425 intact:EBI-1048857|ensembl:ENSP00000217515|ensembl:ENSP00000464918 psi-mi:uchl5_human(display_long)|uniprotkb:Ubiquitin thioesterase L5(gene name synonym)|uniprotkb:Ubiquitin C-terminal hydrolase UCH37(gene name synonym)|uniprotkb:UCHL5(gene name)|psi-mi:UCHL5(display_short)|uniprotkb:UCH37(gene name synonym)|uniprotkb:AD-019(orf name)|uniprotkb:CGI-70(orf name) psi-mi:txnl1_human(display_long)|uniprotkb:32 kDa thioredoxin-related protein(gene name synonym)|uniprotkb:TXNL1(gene name)|psi-mi:TXNL1(display_short)|uniprotkb:TRP32(gene name synonym)|uniprotkb:TXL(gene name synonym)|uniprotkb:TXNL(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511218|imex:IM-12079-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001186190.1|refseq:NP_001186191.1|refseq:NP_001186192.1|refseq:NP_057068.1|ensembl:ENSG00000116750(gene)|ensembl:ENST00000367455(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0021670"(lateral ventricle development)|go:"GO:0030901"(midbrain development)|go:"GO:0031011"(Ino80 complex)|go:"GO:0031597"(cytosolic proteasome complex)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0048853"(forebrain morphogenesis)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070628"(proteasome binding)|interpro:IPR001578(Peptidase C12, ubiquitin carboxyl-terminal hydrolase 1)|interpro:IPR017390(Ubiquitinyl hydrolase, UCH37 type)|interpro:IPR033837|interpro:IPR036959|interpro:IPR038765|interpro:IPR041507|mint:Q9Y5K5|rcsb pdb:3A7S|rcsb pdb:3IHR|rcsb pdb:3RII|rcsb pdb:3RIS|rcsb pdb:3TB3|rcsb pdb:4UEL|rcsb pdb:4UEM|rcsb pdb:4UF5|rcsb pdb:4UF6|rcsb pdb:4WLP|reactome:R-HSA-2173788|reactome:R-HSA-5689603|dip:DIP-42671N refseq:NP_004777.1|ensembl:ENSG00000091164(gene)|ensembl:ENST00000217515(transcript)|ensembl:ENST00000590954(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0015036"(disulfide oxidoreductase activity)|interpro:IPR008979(Galactose-binding like)|interpro:IPR010400(Protein of unknown function DUF1000)|interpro:IPR013766(Thioredoxin domain)|interpro:IPR017937|interpro:IPR036249|interpro:IPR037047|mint:O43396|rcsb pdb:1GH2|rcsb pdb:1WWY|reactome:R-HSA-9013418|reactome:R-HSA-9013420|reactome:R-HSA-9013422|reactome:R-HSA-9013424|reactome:R-HSA-9696264|reactome:R-HSA-9696270|reactome:R-HSA-9696273|refseq:XP_016881582.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:gRm5ttq5Tc0cBIOQ1ut2ugzbMTY9606 rogid:v3qpLTWgZZ1f4Tz/ixVYlSPv7Ro9606 intact-crc:8048E4F3002361C1|rigid:5TE1CyyNtrgsGHuW/ZDbdWfMAUQ false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y5K5 uniprotkb:P54727 intact:EBI-1051183|uniprotkb:Q5LJA6|uniprotkb:Q5LJA7|uniprotkb:Q8TBS4|uniprotkb:Q96BJ9|uniprotkb:Q9H1W5|uniprotkb:Q9P0I3|uniprotkb:Q9UQN2|ensembl:ENSP00000356425 intact:EBI-954531|uniprotkb:Q8WUB0|uniprotkb:B3KWK8|ensembl:ENSP00000350708|uniprotkb:G5E9P0|uniprotkb:Q7Z5K8 psi-mi:uchl5_human(display_long)|uniprotkb:Ubiquitin thioesterase L5(gene name synonym)|uniprotkb:Ubiquitin C-terminal hydrolase UCH37(gene name synonym)|uniprotkb:UCHL5(gene name)|psi-mi:UCHL5(display_short)|uniprotkb:UCH37(gene name synonym)|uniprotkb:AD-019(orf name)|uniprotkb:CGI-70(orf name) psi-mi:rd23b_human(display_long)|uniprotkb:XP-C repair-complementing complex 58 kDa protein(gene name synonym)|uniprotkb:RAD23B(gene name)|psi-mi:RAD23B(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511218|imex:IM-12079-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001186190.1|refseq:NP_001186191.1|refseq:NP_001186192.1|refseq:NP_057068.1|ensembl:ENSG00000116750(gene)|ensembl:ENST00000367455(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0021670"(lateral ventricle development)|go:"GO:0030901"(midbrain development)|go:"GO:0031011"(Ino80 complex)|go:"GO:0031597"(cytosolic proteasome complex)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0048853"(forebrain morphogenesis)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070628"(proteasome binding)|interpro:IPR001578(Peptidase C12, ubiquitin carboxyl-terminal hydrolase 1)|interpro:IPR017390(Ubiquitinyl hydrolase, UCH37 type)|interpro:IPR033837|interpro:IPR036959|interpro:IPR038765|interpro:IPR041507|mint:Q9Y5K5|rcsb pdb:3A7S|rcsb pdb:3IHR|rcsb pdb:3RII|rcsb pdb:3RIS|rcsb pdb:3TB3|rcsb pdb:4UEL|rcsb pdb:4UEM|rcsb pdb:4UF5|rcsb pdb:4UF6|rcsb pdb:4WLP|reactome:R-HSA-2173788|reactome:R-HSA-5689603|dip:DIP-42671N refseq:NP_002865.1|refseq:NP_001231653.1|ensembl:ENSG00000119318(gene)|ensembl:ENST00000358015(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0000715"(nucleotide-excision repair, DNA damage recognition)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0007283"(spermatogenesis)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0032434"(regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0048568"(embryonic organ development)|go:"GO:0070628"(proteasome binding)|go:"GO:0071942"(XPC complex)|go:"GO:0098761"(cellular response to interleukin-7)|interpro:IPR000626(Ubiquitin)|interpro:IPR004806(UV excision repair protein Rad23)|interpro:IPR006636(Heat shock chaperonin-binding)|interpro:IPR009060(UBA-like)|interpro:IPR015360(XPC-binding domain)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR036353|interpro:IPR041811|mint:P54727|rcsb pdb:1P1A|rcsb pdb:1PVE|rcsb pdb:1UEL|reactome:R-HSA-532668|reactome:R-HSA-5689877|reactome:R-HSA-5696394|reactome:R-HSA-5696395|interpro:IPR029071|dip:DIP-39944N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:gRm5ttq5Tc0cBIOQ1ut2ugzbMTY9606 rogid:msyh4+G2TzDW+xgGjixPKWWrjRE9606 intact-crc:8048E4F3002361C1|rigid:5TE1CyyNtrgsGHuW/ZDbdWfMAUQ false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y5K5 uniprotkb:P43686 intact:EBI-1051183|uniprotkb:Q5LJA6|uniprotkb:Q5LJA7|uniprotkb:Q8TBS4|uniprotkb:Q96BJ9|uniprotkb:Q9H1W5|uniprotkb:Q9P0I3|uniprotkb:Q9UQN2|ensembl:ENSP00000356425 intact:EBI-743997|uniprotkb:Q96FV5|uniprotkb:Q9UBM3|uniprotkb:Q9UEX3|ensembl:ENSP00000157812|ensembl:ENSP00000487367 psi-mi:uchl5_human(display_long)|uniprotkb:Ubiquitin thioesterase L5(gene name synonym)|uniprotkb:Ubiquitin C-terminal hydrolase UCH37(gene name synonym)|uniprotkb:UCHL5(gene name)|psi-mi:UCHL5(display_short)|uniprotkb:UCH37(gene name synonym)|uniprotkb:AD-019(orf name)|uniprotkb:CGI-70(orf name) psi-mi:prs6b_human(display_long)|uniprotkb:Proteasome 26S subunit ATPase 4(gene name synonym)|uniprotkb:MB67-interacting protein(gene name synonym)|uniprotkb:PSMC4(gene name)|psi-mi:PSMC4(display_short)|uniprotkb:TBP7(gene name synonym)|uniprotkb:MIP224(gene name synonym)|uniprotkb:Tat-binding protein 7(gene name synonym)|uniprotkb:26S proteasome AAA-ATPase subunit RPT3(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511218|imex:IM-12079-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001186190.1|refseq:NP_001186191.1|refseq:NP_001186192.1|refseq:NP_057068.1|ensembl:ENSG00000116750(gene)|ensembl:ENST00000367455(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0021670"(lateral ventricle development)|go:"GO:0030901"(midbrain development)|go:"GO:0031011"(Ino80 complex)|go:"GO:0031597"(cytosolic proteasome complex)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0048853"(forebrain morphogenesis)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070628"(proteasome binding)|interpro:IPR001578(Peptidase C12, ubiquitin carboxyl-terminal hydrolase 1)|interpro:IPR017390(Ubiquitinyl hydrolase, UCH37 type)|interpro:IPR033837|interpro:IPR036959|interpro:IPR038765|interpro:IPR041507|mint:Q9Y5K5|rcsb pdb:3A7S|rcsb pdb:3IHR|rcsb pdb:3RII|rcsb pdb:3RIS|rcsb pdb:3TB3|rcsb pdb:4UEL|rcsb pdb:4UEM|rcsb pdb:4UF5|rcsb pdb:4UF6|rcsb pdb:4WLP|reactome:R-HSA-2173788|reactome:R-HSA-5689603|dip:DIP-42671N refseq:NP_006494.1|refseq:NP_694546.1|dip:DIP-29274N|ensembl:ENSG00000013275(gene)|ensembl:ENSG00000281221(gene)|ensembl:ENST00000157812(transcript)|ensembl:ENST00000629691(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0001824"(blastocyst development)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0030163"(protein catabolic process)|go:"GO:0031597"(cytosolic proteasome complex)|go:"GO:0036402"(proteasome-activating activity)|go:"GO:0045202"(synapse)|go:"GO:0045899"(positive regulation of RNA polymerase II transcription preinitiation complex assembly)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR005937(26S proteasome subunit P45)|interpro:IPR027417|interpro:IPR032501|interpro:IPR035256|interpro:IPR041569|mint:P43686|rcsb pdb:2DVW|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4G|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VGZ|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHJ|rcsb pdb:5VHM|rcsb pdb:5VHN|rcsb pdb:5VHO|rcsb pdb:5VHP|rcsb pdb:5VHQ|rcsb pdb:5VHR|rcsb pdb:5VHS|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|reactome:R-HSA-69601 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:gRm5ttq5Tc0cBIOQ1ut2ugzbMTY9606 rogid:ZwHUFX8vJa8IPZi000dHiFtUtlM9606 intact-crc:8048E4F3002361C1|rigid:5TE1CyyNtrgsGHuW/ZDbdWfMAUQ false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y5K5 uniprotkb:O75832 intact:EBI-1051183|uniprotkb:Q5LJA6|uniprotkb:Q5LJA7|uniprotkb:Q8TBS4|uniprotkb:Q96BJ9|uniprotkb:Q9H1W5|uniprotkb:Q9P0I3|uniprotkb:Q9UQN2|ensembl:ENSP00000356425 intact:EBI-752185|uniprotkb:Q8IZK9|uniprotkb:Q5U0B2|ensembl:ENSP00000217958 psi-mi:uchl5_human(display_long)|uniprotkb:Ubiquitin thioesterase L5(gene name synonym)|uniprotkb:Ubiquitin C-terminal hydrolase UCH37(gene name synonym)|uniprotkb:UCHL5(gene name)|psi-mi:UCHL5(display_short)|uniprotkb:UCH37(gene name synonym)|uniprotkb:AD-019(orf name)|uniprotkb:CGI-70(orf name) psi-mi:psd10_human(display_long)|uniprotkb:26S proteasome regulatory subunit p28(gene name synonym)|uniprotkb:Gankyrin(gene name synonym)|uniprotkb:PSMD10(gene name)|psi-mi:PSMD10(display_short)|uniprotkb:"p28(GANK)"(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511218|imex:IM-12079-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001186190.1|refseq:NP_001186191.1|refseq:NP_001186192.1|refseq:NP_057068.1|ensembl:ENSG00000116750(gene)|ensembl:ENST00000367455(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0021670"(lateral ventricle development)|go:"GO:0030901"(midbrain development)|go:"GO:0031011"(Ino80 complex)|go:"GO:0031597"(cytosolic proteasome complex)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0048853"(forebrain morphogenesis)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070628"(proteasome binding)|interpro:IPR001578(Peptidase C12, ubiquitin carboxyl-terminal hydrolase 1)|interpro:IPR017390(Ubiquitinyl hydrolase, UCH37 type)|interpro:IPR033837|interpro:IPR036959|interpro:IPR038765|interpro:IPR041507|mint:Q9Y5K5|rcsb pdb:3A7S|rcsb pdb:3IHR|rcsb pdb:3RII|rcsb pdb:3RIS|rcsb pdb:3TB3|rcsb pdb:4UEL|rcsb pdb:4UEM|rcsb pdb:4UF5|rcsb pdb:4UF6|rcsb pdb:4WLP|reactome:R-HSA-2173788|reactome:R-HSA-5689603|dip:DIP-42671N refseq:NP_002805.1|refseq:NP_736606.1|dip:DIP-39026N|ensembl:ENSG00000101843(gene)|ensembl:ENST00000217958(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000502"(proteasome complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0008134"(transcription factor binding)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0043518"(negative regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0070682"(proteasome regulatory particle assembly)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR036770|go:"GO:0007253"(cytoplasmic sequestering of NF-kappaB)|mint:O75832|rcsb pdb:1QYM|rcsb pdb:1TR4|rcsb pdb:1UOH|rcsb pdb:4NIK|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHJ|rcsb pdb:5VHM|rcsb pdb:5VHN|rcsb pdb:5VHO|rcsb pdb:5VHP|rcsb pdb:5VHQ|rcsb pdb:5VHR|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|interpro:IPR039334|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|reactome:R-HSA-8951664 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:gRm5ttq5Tc0cBIOQ1ut2ugzbMTY9606 rogid:HJ1dl0tNhvWH7pSVWKpadkqe8A09606 intact-crc:8048E4F3002361C1|rigid:5TE1CyyNtrgsGHuW/ZDbdWfMAUQ false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y5K5 uniprotkb:P48556 intact:EBI-1051183|uniprotkb:Q5LJA6|uniprotkb:Q5LJA7|uniprotkb:Q8TBS4|uniprotkb:Q96BJ9|uniprotkb:Q9H1W5|uniprotkb:Q9P0I3|uniprotkb:Q9UQN2|ensembl:ENSP00000356425 intact:EBI-359304|uniprotkb:Q6P1L7|uniprotkb:B4DX18|ensembl:ENSP00000215071|ensembl:ENSP00000481136 psi-mi:uchl5_human(display_long)|uniprotkb:Ubiquitin thioesterase L5(gene name synonym)|uniprotkb:Ubiquitin C-terminal hydrolase UCH37(gene name synonym)|uniprotkb:UCHL5(gene name)|psi-mi:UCHL5(display_short)|uniprotkb:UCH37(gene name synonym)|uniprotkb:AD-019(orf name)|uniprotkb:CGI-70(orf name) psi-mi:psmd8_human(display_long)|uniprotkb:PSMD8(gene name)|psi-mi:PSMD8(display_short)|uniprotkb:26S proteasome regulatory subunit S14(gene name synonym)|uniprotkb:p31(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN12(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511218|imex:IM-12079-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001186190.1|refseq:NP_001186191.1|refseq:NP_001186192.1|refseq:NP_057068.1|ensembl:ENSG00000116750(gene)|ensembl:ENST00000367455(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0021670"(lateral ventricle development)|go:"GO:0030901"(midbrain development)|go:"GO:0031011"(Ino80 complex)|go:"GO:0031597"(cytosolic proteasome complex)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0048853"(forebrain morphogenesis)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070628"(proteasome binding)|interpro:IPR001578(Peptidase C12, ubiquitin carboxyl-terminal hydrolase 1)|interpro:IPR017390(Ubiquitinyl hydrolase, UCH37 type)|interpro:IPR033837|interpro:IPR036959|interpro:IPR038765|interpro:IPR041507|mint:Q9Y5K5|rcsb pdb:3A7S|rcsb pdb:3IHR|rcsb pdb:3RII|rcsb pdb:3RIS|rcsb pdb:3TB3|rcsb pdb:4UEL|rcsb pdb:4UEM|rcsb pdb:4UF5|rcsb pdb:4UF6|rcsb pdb:4WLP|reactome:R-HSA-2173788|reactome:R-HSA-5689603|dip:DIP-42671N refseq:NP_002803.2|ensembl:ENSG00000099341(gene)|ensembl:ENST00000215071(transcript)|ensembl:ENST00000620216(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0008541"(proteasome regulatory particle, lid subcomplex)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR006746(26S proteasome non-ATPase regulatory subunit Rpn12)|interpro:IPR033464|mint:P48556|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5M32|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VGZ|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHS|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|reactome:R-HSA-180534 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:gRm5ttq5Tc0cBIOQ1ut2ugzbMTY9606 rogid:73qmlkzCwdeHlNzUy7vy7qmIok09606 intact-crc:8048E4F3002361C1|rigid:5TE1CyyNtrgsGHuW/ZDbdWfMAUQ false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y5K5 uniprotkb:O43242 intact:EBI-1051183|uniprotkb:Q5LJA6|uniprotkb:Q5LJA7|uniprotkb:Q8TBS4|uniprotkb:Q96BJ9|uniprotkb:Q9H1W5|uniprotkb:Q9P0I3|uniprotkb:Q9UQN2|ensembl:ENSP00000356425 intact:EBI-357622|uniprotkb:Q96EI2|uniprotkb:Q9BQA4|ensembl:ENSP00000264639|uniprotkb:B4DT72|uniprotkb:B3KMW9 psi-mi:uchl5_human(display_long)|uniprotkb:Ubiquitin thioesterase L5(gene name synonym)|uniprotkb:Ubiquitin C-terminal hydrolase UCH37(gene name synonym)|uniprotkb:UCHL5(gene name)|psi-mi:UCHL5(display_short)|uniprotkb:UCH37(gene name synonym)|uniprotkb:AD-019(orf name)|uniprotkb:CGI-70(orf name) psi-mi:psmd3_human(display_long)|uniprotkb:PSMD3(gene name)|psi-mi:PSMD3(display_short)|uniprotkb:Proteasome subunit p58(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S3(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN3(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511218|imex:IM-12079-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001186190.1|refseq:NP_001186191.1|refseq:NP_001186192.1|refseq:NP_057068.1|ensembl:ENSG00000116750(gene)|ensembl:ENST00000367455(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0021670"(lateral ventricle development)|go:"GO:0030901"(midbrain development)|go:"GO:0031011"(Ino80 complex)|go:"GO:0031597"(cytosolic proteasome complex)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0048853"(forebrain morphogenesis)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070628"(proteasome binding)|interpro:IPR001578(Peptidase C12, ubiquitin carboxyl-terminal hydrolase 1)|interpro:IPR017390(Ubiquitinyl hydrolase, UCH37 type)|interpro:IPR033837|interpro:IPR036959|interpro:IPR038765|interpro:IPR041507|mint:Q9Y5K5|rcsb pdb:3A7S|rcsb pdb:3IHR|rcsb pdb:3RII|rcsb pdb:3RIS|rcsb pdb:3TB3|rcsb pdb:4UEL|rcsb pdb:4UEM|rcsb pdb:4UF5|rcsb pdb:4UF6|rcsb pdb:4WLP|reactome:R-HSA-2173788|reactome:R-HSA-5689603|dip:DIP-42671N ensembl:ENSG00000108344(gene)|ensembl:ENST00000264639(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008541"(proteasome regulatory particle, lid subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013586(26S proteasome regulatory subunit, C-terminal)|interpro:IPR035267|interpro:IPR036390|mint:O43242|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VGZ|rcsb pdb:5VHF|reactome:R-HSA-174113|reactome:R-HSA-174154|rcsb pdb:5VHH|rcsb pdb:5VHI|reactome:R-HSA-174178|rcsb pdb:5VHS|reactome:R-HSA-174184|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6MSH|reactome:R-HSA-180534|rcsb pdb:6MSJ|reactome:R-HSA-180585|reactome:R-HSA-187577|rcsb pdb:6MSK|reactome:R-HSA-195253|reactome:R-HSA-202424|rcsb pdb:6WJD|reactome:R-HSA-211733|rcsb pdb:6WJN|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-174084|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5607761|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|reactome:R-HSA-8854050|refseq:NP_002800.2|dip:DIP-27571N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:gRm5ttq5Tc0cBIOQ1ut2ugzbMTY9606 rogid:C6CStW89nIAA3mzubyv5wfBwPHk9606 intact-crc:8048E4F3002361C1|rigid:5TE1CyyNtrgsGHuW/ZDbdWfMAUQ false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y5K5 uniprotkb:O00487 intact:EBI-1051183|uniprotkb:Q5LJA6|uniprotkb:Q5LJA7|uniprotkb:Q8TBS4|uniprotkb:Q96BJ9|uniprotkb:Q9H1W5|uniprotkb:Q9P0I3|uniprotkb:Q9UQN2|ensembl:ENSP00000356425 intact:EBI-722193|uniprotkb:O00176|uniprotkb:B3KNW2|ensembl:ENSP00000386541 psi-mi:uchl5_human(display_long)|uniprotkb:Ubiquitin thioesterase L5(gene name synonym)|uniprotkb:Ubiquitin C-terminal hydrolase UCH37(gene name synonym)|uniprotkb:UCHL5(gene name)|psi-mi:UCHL5(display_short)|uniprotkb:UCH37(gene name synonym)|uniprotkb:AD-019(orf name)|uniprotkb:CGI-70(orf name) psi-mi:psde_human(display_long)|uniprotkb:26S proteasome regulatory subunit RPN11(gene name synonym)|uniprotkb:26S proteasome-associated PAD1 homolog 1(gene name synonym)|uniprotkb:PSMD14(gene name)|psi-mi:PSMD14(display_short)|uniprotkb:POH1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511218|imex:IM-12079-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001186190.1|refseq:NP_001186191.1|refseq:NP_001186192.1|refseq:NP_057068.1|ensembl:ENSG00000116750(gene)|ensembl:ENST00000367455(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0021670"(lateral ventricle development)|go:"GO:0030901"(midbrain development)|go:"GO:0031011"(Ino80 complex)|go:"GO:0031597"(cytosolic proteasome complex)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0048853"(forebrain morphogenesis)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070628"(proteasome binding)|interpro:IPR001578(Peptidase C12, ubiquitin carboxyl-terminal hydrolase 1)|interpro:IPR017390(Ubiquitinyl hydrolase, UCH37 type)|interpro:IPR033837|interpro:IPR036959|interpro:IPR038765|interpro:IPR041507|mint:Q9Y5K5|rcsb pdb:3A7S|rcsb pdb:3IHR|rcsb pdb:3RII|rcsb pdb:3RIS|rcsb pdb:3TB3|rcsb pdb:4UEL|rcsb pdb:4UEM|rcsb pdb:4UF5|rcsb pdb:4UF6|rcsb pdb:4WLP|reactome:R-HSA-2173788|reactome:R-HSA-5689603|dip:DIP-42671N refseq:NP_005796.1|ensembl:ENSG00000115233(gene)|ensembl:ENST00000409682(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008541"(proteasome regulatory particle, lid subcomplex)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0031597"(cytosolic proteasome complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0046872"(metal ion binding)|go:"GO:0061133"(endopeptidase activator activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0061578"(Lys63-specific deubiquitinase activity)|go:"GO:0070122"(isopeptidase activity)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0070628"(proteasome binding)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR024969|interpro:IPR035299|interpro:IPR037518|mint:O00487|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VGZ|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHS|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5689901|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:gRm5ttq5Tc0cBIOQ1ut2ugzbMTY9606 rogid:pSM+755ZbQisR5S0ZivcYBu9Bc49606 intact-crc:8048E4F3002361C1|rigid:5TE1CyyNtrgsGHuW/ZDbdWfMAUQ false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y5K5 uniprotkb:Q99460 intact:EBI-1051183|uniprotkb:Q5LJA6|uniprotkb:Q5LJA7|uniprotkb:Q8TBS4|uniprotkb:Q96BJ9|uniprotkb:Q9H1W5|uniprotkb:Q9P0I3|uniprotkb:Q9UQN2|ensembl:ENSP00000356425 intact:EBI-357874|uniprotkb:Q24JU0|uniprotkb:Q53TI2|uniprotkb:Q6GMU5|uniprotkb:Q6P2P4|uniprotkb:Q6PJM7|uniprotkb:Q6PKG9|uniprotkb:B8ZZH9|uniprotkb:Q86VU1|uniprotkb:Q8IV79|ensembl:ENSP00000309474|ensembl:ENSP00000503068 psi-mi:uchl5_human(display_long)|uniprotkb:Ubiquitin thioesterase L5(gene name synonym)|uniprotkb:Ubiquitin C-terminal hydrolase UCH37(gene name synonym)|uniprotkb:UCHL5(gene name)|psi-mi:UCHL5(display_short)|uniprotkb:UCH37(gene name synonym)|uniprotkb:AD-019(orf name)|uniprotkb:CGI-70(orf name) psi-mi:psmd1_human(display_long)|uniprotkb:PSMD1(gene name)|psi-mi:PSMD1(display_short)|uniprotkb:26S proteasome regulatory subunit RPN2(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S1(gene name synonym)|uniprotkb:26S proteasome subunit p112(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511218|imex:IM-12079-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001186190.1|refseq:NP_001186191.1|refseq:NP_001186192.1|refseq:NP_057068.1|ensembl:ENSG00000116750(gene)|ensembl:ENST00000367455(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0021670"(lateral ventricle development)|go:"GO:0030901"(midbrain development)|go:"GO:0031011"(Ino80 complex)|go:"GO:0031597"(cytosolic proteasome complex)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0048853"(forebrain morphogenesis)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070628"(proteasome binding)|interpro:IPR001578(Peptidase C12, ubiquitin carboxyl-terminal hydrolase 1)|interpro:IPR017390(Ubiquitinyl hydrolase, UCH37 type)|interpro:IPR033837|interpro:IPR036959|interpro:IPR038765|interpro:IPR041507|mint:Q9Y5K5|rcsb pdb:3A7S|rcsb pdb:3IHR|rcsb pdb:3RII|rcsb pdb:3RIS|rcsb pdb:3TB3|rcsb pdb:4UEL|rcsb pdb:4UEM|rcsb pdb:4UF5|rcsb pdb:4UF6|rcsb pdb:4WLP|reactome:R-HSA-2173788|reactome:R-HSA-5689603|dip:DIP-42671N refseq:NP_001177966.1|refseq:NP_002798.2|dip:DIP-27548N|ensembl:ENSG00000173692(gene)|ensembl:ENST00000308696(transcript)|ensembl:ENST00000677230(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034515"(proteasome storage granule)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|interpro:IPR002015(Proteasome/cyclosome, regulatory subunit)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016642(26S proteasome regulatory complex, non-ATPase subcomplex, Rpn2/Psmd1 subunit)|interpro:IPR035266|interpro:IPR040623|mint:Q99460|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5V1Y|rcsb pdb:5V1Z|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VGZ|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHS|rcsb pdb:6CO4|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6OI4|rcsb pdb:6UYI|rcsb pdb:6UYJ|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-382556|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:gRm5ttq5Tc0cBIOQ1ut2ugzbMTY9606 rogid:aGYxoT30PhzvF/CiurQLDb8Ewrs9606 intact-crc:8048E4F3002361C1|rigid:5TE1CyyNtrgsGHuW/ZDbdWfMAUQ false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y5K5 uniprotkb:O00231 intact:EBI-1051183|uniprotkb:Q5LJA6|uniprotkb:Q5LJA7|uniprotkb:Q8TBS4|uniprotkb:Q96BJ9|uniprotkb:Q9H1W5|uniprotkb:Q9P0I3|uniprotkb:Q9UQN2|ensembl:ENSP00000356425 intact:EBI-357816|uniprotkb:O00495|uniprotkb:A8K3I7|uniprotkb:E1P663|uniprotkb:Q53FT5|ensembl:ENSP00000261712|ensembl:ENSP00000393185|ensembl:ENSP00000497128 psi-mi:uchl5_human(display_long)|uniprotkb:Ubiquitin thioesterase L5(gene name synonym)|uniprotkb:Ubiquitin C-terminal hydrolase UCH37(gene name synonym)|uniprotkb:UCHL5(gene name)|psi-mi:UCHL5(display_short)|uniprotkb:UCH37(gene name synonym)|uniprotkb:AD-019(orf name)|uniprotkb:CGI-70(orf name) psi-mi:psd11_human(display_long)|uniprotkb:PSMD11(gene name)|psi-mi:PSMD11(display_short)|uniprotkb:26S proteasome regulatory subunit S9(gene name synonym)|uniprotkb:26S proteasome regulatory subunit p44.5(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN6(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511218|imex:IM-12079-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001186190.1|refseq:NP_001186191.1|refseq:NP_001186192.1|refseq:NP_057068.1|ensembl:ENSG00000116750(gene)|ensembl:ENST00000367455(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0021670"(lateral ventricle development)|go:"GO:0030901"(midbrain development)|go:"GO:0031011"(Ino80 complex)|go:"GO:0031597"(cytosolic proteasome complex)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0048853"(forebrain morphogenesis)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070628"(proteasome binding)|interpro:IPR001578(Peptidase C12, ubiquitin carboxyl-terminal hydrolase 1)|interpro:IPR017390(Ubiquitinyl hydrolase, UCH37 type)|interpro:IPR033837|interpro:IPR036959|interpro:IPR038765|interpro:IPR041507|mint:Q9Y5K5|rcsb pdb:3A7S|rcsb pdb:3IHR|rcsb pdb:3RII|rcsb pdb:3RIS|rcsb pdb:3TB3|rcsb pdb:4UEL|rcsb pdb:4UEM|rcsb pdb:4UF5|rcsb pdb:4UF6|rcsb pdb:4WLP|reactome:R-HSA-2173788|reactome:R-HSA-5689603|dip:DIP-42671N refseq:NP_002806.2|refseq:NP_001257411.1|ensembl:ENSG00000108671(gene)|ensembl:ENST00000261712(transcript)|ensembl:ENST00000457654(transcript)|ensembl:ENST00000649012(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008541"(proteasome regulatory particle, lid subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0043248"(proteasome assembly)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR035295|interpro:IPR036390|interpro:IPR040773|interpro:IPR040780|mint:O00231|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5M32|rcsb pdb:5LN3|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VGZ|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHS|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:gRm5ttq5Tc0cBIOQ1ut2ugzbMTY9606 rogid:BgQKXK7gMMihacRCI+g/pBnRN309606 intact-crc:8048E4F3002361C1|rigid:5TE1CyyNtrgsGHuW/ZDbdWfMAUQ false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y5K5 uniprotkb:P62195 intact:EBI-1051183|uniprotkb:Q5LJA6|uniprotkb:Q5LJA7|uniprotkb:Q8TBS4|uniprotkb:Q96BJ9|uniprotkb:Q9H1W5|uniprotkb:Q9P0I3|uniprotkb:Q9UQN2|ensembl:ENSP00000356425 intact:EBI-357745|uniprotkb:O35051|uniprotkb:O43208|uniprotkb:P52915|uniprotkb:P47210|uniprotkb:P52916|uniprotkb:A8K763|uniprotkb:A8K3Z3|ensembl:ENSP00000310572 psi-mi:uchl5_human(display_long)|uniprotkb:Ubiquitin thioesterase L5(gene name synonym)|uniprotkb:Ubiquitin C-terminal hydrolase UCH37(gene name synonym)|uniprotkb:UCHL5(gene name)|psi-mi:UCHL5(display_short)|uniprotkb:UCH37(gene name synonym)|uniprotkb:AD-019(orf name)|uniprotkb:CGI-70(orf name) psi-mi:prs8_human(display_long)|uniprotkb:PSMC5(gene name)|psi-mi:PSMC5(display_short)|uniprotkb:SUG1(gene name synonym)|uniprotkb:Proteasome 26S subunit ATPase 5(gene name synonym)|uniprotkb:Proteasome subunit p45(gene name synonym)|uniprotkb:p45/SUG(gene name synonym)|uniprotkb:Thyroid hormone receptor-interacting protein 1(gene name synonym)|uniprotkb:26S proteasome AAA-ATPase subunit RPT6(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511218|imex:IM-12079-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001186190.1|refseq:NP_001186191.1|refseq:NP_001186192.1|refseq:NP_057068.1|ensembl:ENSG00000116750(gene)|ensembl:ENST00000367455(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0021670"(lateral ventricle development)|go:"GO:0030901"(midbrain development)|go:"GO:0031011"(Ino80 complex)|go:"GO:0031597"(cytosolic proteasome complex)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0048853"(forebrain morphogenesis)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070628"(proteasome binding)|interpro:IPR001578(Peptidase C12, ubiquitin carboxyl-terminal hydrolase 1)|interpro:IPR017390(Ubiquitinyl hydrolase, UCH37 type)|interpro:IPR033837|interpro:IPR036959|interpro:IPR038765|interpro:IPR041507|mint:Q9Y5K5|rcsb pdb:3A7S|rcsb pdb:3IHR|rcsb pdb:3RII|rcsb pdb:3RIS|rcsb pdb:3TB3|rcsb pdb:4UEL|rcsb pdb:4UEM|rcsb pdb:4UF5|rcsb pdb:4UF6|rcsb pdb:4WLP|reactome:R-HSA-2173788|reactome:R-HSA-5689603|dip:DIP-42671N refseq:NP_001186092.1|refseq:NP_002796.4|reactome:R-HSA-195253|ensembl:ENSG00000087191(gene)|ensembl:ENST00000310144(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0017025"(TBP-class protein binding)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031531"(thyrotropin-releasing hormone receptor binding)|go:"GO:0031595"(nuclear proteasome complex)|go:"GO:0031597"(cytosolic proteasome complex)|go:"GO:0036402"(proteasome-activating activity)|go:"GO:0043069"(negative regulation of programmed cell death)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045899"(positive regulation of RNA polymerase II transcription preinitiation complex assembly)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0090261"(positive regulation of inclusion body assembly)|go:"GO:0098794"(postsynapse)|go:"GO:0140296"(general transcription initiation factor binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR005937(26S proteasome subunit P45)|interpro:IPR027417|interpro:IPR032501|interpro:IPR041569|mint:P62195|rcsb pdb:2KRK|rcsb pdb:3KW6|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4G|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VGZ|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHJ|rcsb pdb:5VHM|rcsb pdb:5VHN|rcsb pdb:5VHO|rcsb pdb:5VHP|rcsb pdb:5VHQ|rcsb pdb:5VHR|rcsb pdb:5VHS|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|dip:DIP-36645N psi-mi:"MI:0469"(intact) - crc64:29C6410C4A85A7F7 figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:gRm5ttq5Tc0cBIOQ1ut2ugzbMTY9606 rogid:zgUTOX/O4m86U/Nf+pnT7u0m0gY9606 intact-crc:8048E4F3002361C1|rigid:5TE1CyyNtrgsGHuW/ZDbdWfMAUQ false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y5K5 uniprotkb:P0C1Z6 intact:EBI-1051183|uniprotkb:Q5LJA6|uniprotkb:Q5LJA7|uniprotkb:Q8TBS4|uniprotkb:Q96BJ9|uniprotkb:Q9H1W5|uniprotkb:Q9P0I3|uniprotkb:Q9UQN2|ensembl:ENSP00000356425 intact:EBI-1245626|uniprotkb:G5E9B5|ensembl:ENSP00000375639|ensembl:ENSP00000477775|ensembl:ENSP00000480169|ensembl:ENSP00000480353|ensembl:ENSP00000481443|ensembl:ENSP00000482185|ensembl:ENSP00000482785|ensembl:ENSP00000483417|ensembl:ENSP00000483971|ensembl:ENSP00000484685 psi-mi:uchl5_human(display_long)|uniprotkb:Ubiquitin thioesterase L5(gene name synonym)|uniprotkb:Ubiquitin C-terminal hydrolase UCH37(gene name synonym)|uniprotkb:UCHL5(gene name)|psi-mi:UCHL5(display_short)|uniprotkb:UCH37(gene name synonym)|uniprotkb:AD-019(orf name)|uniprotkb:CGI-70(orf name) psi-mi:tfpt_human(display_long)|uniprotkb:TFPT(gene name)|psi-mi:TFPT(display_short)|uniprotkb:Protein FB1(gene name synonym)|uniprotkb:INO80F(gene name synonym)|uniprotkb:INO80 complex subunit F(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511218|imex:IM-12079-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001186190.1|refseq:NP_001186191.1|refseq:NP_001186192.1|refseq:NP_057068.1|ensembl:ENSG00000116750(gene)|ensembl:ENST00000367455(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0021670"(lateral ventricle development)|go:"GO:0030901"(midbrain development)|go:"GO:0031011"(Ino80 complex)|go:"GO:0031597"(cytosolic proteasome complex)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0048853"(forebrain morphogenesis)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070628"(proteasome binding)|interpro:IPR001578(Peptidase C12, ubiquitin carboxyl-terminal hydrolase 1)|interpro:IPR017390(Ubiquitinyl hydrolase, UCH37 type)|interpro:IPR033837|interpro:IPR036959|interpro:IPR038765|interpro:IPR041507|mint:Q9Y5K5|rcsb pdb:3A7S|rcsb pdb:3IHR|rcsb pdb:3RII|rcsb pdb:3RIS|rcsb pdb:3TB3|rcsb pdb:4UEL|rcsb pdb:4UEM|rcsb pdb:4UF5|rcsb pdb:4UF6|rcsb pdb:4WLP|reactome:R-HSA-2173788|reactome:R-HSA-5689603|dip:DIP-42671N refseq:NP_037474.1|refseq:NP_001308721.1|ensembl:ENSG00000105619(gene)|ensembl:ENSG00000273833(gene)|ensembl:ENSG00000274073(gene)|ensembl:ENSG00000275086(gene)|ensembl:ENSG00000276022(gene)|ensembl:ENSG00000276263(gene)|ensembl:ENSG00000276296(gene)|ensembl:ENSG00000276323(gene)|ensembl:ENSG00000276504(gene)|ensembl:ENSG00000278161(gene)|ensembl:ENST00000391759(transcript)|ensembl:ENST00000611514(transcript)|ensembl:ENST00000611935(transcript)|ensembl:ENST00000614788(transcript)|ensembl:ENST00000615534(transcript)|ensembl:ENST00000615620(transcript)|ensembl:ENST00000616277(transcript)|ensembl:ENST00000616798(transcript)|ensembl:ENST00000617348(transcript)|ensembl:ENST00000619581(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0031011"(Ino80 complex)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0097190"(apoptotic signaling pathway)|interpro:IPR033555|mint:P0C1Z6|reactome:R-HSA-5689603|reactome:R-HSA-5696394 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:gRm5ttq5Tc0cBIOQ1ut2ugzbMTY9606 rogid:juI/3gZemjc0hnXDJ9J+bIQ9pBw9606 intact-crc:8048E4F3002361C1|rigid:5TE1CyyNtrgsGHuW/ZDbdWfMAUQ false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y5K5 uniprotkb:Q16186 intact:EBI-1051183|uniprotkb:Q5LJA6|uniprotkb:Q5LJA7|uniprotkb:Q8TBS4|uniprotkb:Q96BJ9|uniprotkb:Q9H1W5|uniprotkb:Q9P0I3|uniprotkb:Q9UQN2|ensembl:ENSP00000356425 intact:EBI-954387|ensembl:ENSP00000253003|ensembl:ENSP00000478877|uniprotkb:A0PKB1|uniprotkb:Q96FJ7|uniprotkb:Q9H1P2 psi-mi:uchl5_human(display_long)|uniprotkb:Ubiquitin thioesterase L5(gene name synonym)|uniprotkb:Ubiquitin C-terminal hydrolase UCH37(gene name synonym)|uniprotkb:UCHL5(gene name)|psi-mi:UCHL5(display_short)|uniprotkb:UCH37(gene name synonym)|uniprotkb:AD-019(orf name)|uniprotkb:CGI-70(orf name) psi-mi:adrm1_human(display_long)|uniprotkb:Adhesion-regulating molecule 1(gene name synonym)|uniprotkb:110 kDa cell membrane glycoprotein(gene name synonym)|uniprotkb:Rpn13 homolog(gene name synonym)|uniprotkb:Proteasome regulatory particle non-ATPase 13(gene name synonym)|uniprotkb:ADRM1(gene name)|psi-mi:ADRM1(display_short)|uniprotkb:GP110(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511218|imex:IM-12079-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001186190.1|refseq:NP_001186191.1|refseq:NP_001186192.1|refseq:NP_057068.1|ensembl:ENSG00000116750(gene)|ensembl:ENST00000367455(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0021670"(lateral ventricle development)|go:"GO:0030901"(midbrain development)|go:"GO:0031011"(Ino80 complex)|go:"GO:0031597"(cytosolic proteasome complex)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0048853"(forebrain morphogenesis)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070628"(proteasome binding)|interpro:IPR001578(Peptidase C12, ubiquitin carboxyl-terminal hydrolase 1)|interpro:IPR017390(Ubiquitinyl hydrolase, UCH37 type)|interpro:IPR033837|interpro:IPR036959|interpro:IPR038765|interpro:IPR041507|mint:Q9Y5K5|rcsb pdb:3A7S|rcsb pdb:3IHR|rcsb pdb:3RII|rcsb pdb:3RIS|rcsb pdb:3TB3|rcsb pdb:4UEL|rcsb pdb:4UEM|rcsb pdb:4UF5|rcsb pdb:4UF6|rcsb pdb:4WLP|reactome:R-HSA-2173788|reactome:R-HSA-5689603|dip:DIP-42671N ensembl:ENSG00000130706(gene)|ensembl:ENST00000253003(transcript)|ensembl:ENST00000491935(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0002020"(protease binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008541"(proteasome regulatory particle, lid subcomplex)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043248"(proteasome assembly)|go:"GO:0061133"(endopeptidase activator activity)|go:"GO:0070628"(proteasome binding)|interpro:IPR006773(Adhesion regulating molecule)|interpro:IPR032368|interpro:IPR038108|interpro:IPR038633|interpro:IPR044867|interpro:IPR044868|mint:Q16186|rcsb pdb:2KQZ|rcsb pdb:2KR0|rcsb pdb:2L5V|rcsb pdb:2MKZ|rcsb pdb:2NBV|rcsb pdb:4UEL|rcsb pdb:4UEM|rcsb pdb:4WLQ|rcsb pdb:4WLR|rcsb pdb:5IRS|rcsb pdb:5V1Y|rcsb pdb:5V1Z|rcsb pdb:5YMY|rcsb pdb:6CO4|rcsb pdb:6OI4|rcsb pdb:6UYJ|reactome:R-HSA-5689603|reactome:R-HSA-5689880|rcsb pdb:6UYI|refseq:NP_008933.2|refseq:NP_783163.1|refseq:NP_001268366.1|refseq:NP_001268367.1|refseq:XP_005260314.1|dip:DIP-42668N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:gRm5ttq5Tc0cBIOQ1ut2ugzbMTY9606 rogid:XrSLNnNr5Ojm0HkgcnnPube5Lno9606 intact-crc:8048E4F3002361C1|rigid:5TE1CyyNtrgsGHuW/ZDbdWfMAUQ false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y5K5 uniprotkb:P28074 intact:EBI-1051183|uniprotkb:Q5LJA6|uniprotkb:Q5LJA7|uniprotkb:Q8TBS4|uniprotkb:Q96BJ9|uniprotkb:Q9H1W5|uniprotkb:Q9P0I3|uniprotkb:Q9UQN2|ensembl:ENSP00000356425 intact:EBI-357828|uniprotkb:Q16242|uniprotkb:Q6PEW2|intact:EBI-1237472|uniprotkb:Q7Z3B5|uniprotkb:Q9TNN9|uniprotkb:B2R4N9|uniprotkb:D3DS43|uniprotkb:B4DUM9|uniprotkb:Q86T01|uniprotkb:E9PAV2|ensembl:ENSP00000355325 psi-mi:uchl5_human(display_long)|uniprotkb:Ubiquitin thioesterase L5(gene name synonym)|uniprotkb:Ubiquitin C-terminal hydrolase UCH37(gene name synonym)|uniprotkb:UCHL5(gene name)|psi-mi:UCHL5(display_short)|uniprotkb:UCH37(gene name synonym)|uniprotkb:AD-019(orf name)|uniprotkb:CGI-70(orf name) psi-mi:psb5_human(display_long)|uniprotkb:PSMB5(gene name)|psi-mi:PSMB5(display_short)|uniprotkb:LMPX(gene name synonym)|uniprotkb:Proteasome epsilon chain(gene name synonym)|uniprotkb:Macropain epsilon chain(gene name synonym)|uniprotkb:Multicatalytic endopeptidase complex epsilon chain(gene name synonym)|uniprotkb:Proteasome subunit X(gene name synonym)|uniprotkb:Proteasome chain 6(gene name synonym)|uniprotkb:Proteasome subunit MB1(gene name synonym)|uniprotkb:MB1(gene name synonym)|uniprotkb:X(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511218|imex:IM-12079-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001186190.1|refseq:NP_001186191.1|refseq:NP_001186192.1|refseq:NP_057068.1|ensembl:ENSG00000116750(gene)|ensembl:ENST00000367455(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0021670"(lateral ventricle development)|go:"GO:0030901"(midbrain development)|go:"GO:0031011"(Ino80 complex)|go:"GO:0031597"(cytosolic proteasome complex)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0048853"(forebrain morphogenesis)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070628"(proteasome binding)|interpro:IPR001578(Peptidase C12, ubiquitin carboxyl-terminal hydrolase 1)|interpro:IPR017390(Ubiquitinyl hydrolase, UCH37 type)|interpro:IPR033837|interpro:IPR036959|interpro:IPR038765|interpro:IPR041507|mint:Q9Y5K5|rcsb pdb:3A7S|rcsb pdb:3IHR|rcsb pdb:3RII|rcsb pdb:3RIS|rcsb pdb:3TB3|rcsb pdb:4UEL|rcsb pdb:4UEM|rcsb pdb:4UF5|rcsb pdb:4UF6|rcsb pdb:4WLP|reactome:R-HSA-2173788|reactome:R-HSA-5689603|dip:DIP-42671N refseq:NP_001124197.1|refseq:NP_001138404.1|refseq:NP_002788.1|dip:DIP-27540N|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|reactome:R-HSA-5610785|rcsb pdb:6KWY|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6R70|rcsb pdb:6REY|rcsb pdb:6RGQ|rcsb pdb:6WJD|rcsb pdb:6WJN|rcsb pdb:6XMJ|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|ensembl:ENSG00000100804(gene)|ensembl:ENST00000361611(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004298"(threonine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005839"(proteasome core complex)|go:"GO:0006508"(proteolysis)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008233"(peptidase activity)|go:"GO:0010499"(proteasomal ubiquitin-independent protein catabolic process)|go:"GO:0019774"(proteasome core complex, beta-subunit complex)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000243(Peptidase T1A, proteasome beta-subunit)|interpro:IPR001353(20S proteasome, A and B subunits)|interpro:IPR016050(Proteasome, beta-type subunit, conserved site)|interpro:IPR023333|interpro:IPR029055|interpro:IPR037558|mint:P28074|rcsb pdb:4R3O|rcsb pdb:4R67|rcsb pdb:5A0Q|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4G|rcsb pdb:5L5W|rcsb pdb:5L5X|rcsb pdb:5L5Y|rcsb pdb:5L5Z|rcsb pdb:5L60|rcsb pdb:5L61|rcsb pdb:5L62|rcsb pdb:5L63|rcsb pdb:5L64|rcsb pdb:5LE5|rcsb pdb:5LEX|rcsb pdb:5LEY|rcsb pdb:5LEZ|rcsb pdb:5LF0|rcsb pdb:5LF1|rcsb pdb:5LF3|rcsb pdb:5LF4|rcsb pdb:5LF6|rcsb pdb:5LF7|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFO|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:gRm5ttq5Tc0cBIOQ1ut2ugzbMTY9606 rogid:73T59wniLri/465F3BhBvwL1/LM9606 intact-crc:8048E4F3002361C1|rigid:5TE1CyyNtrgsGHuW/ZDbdWfMAUQ false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y5K5 uniprotkb:P62333 intact:EBI-1051183|uniprotkb:Q5LJA6|uniprotkb:Q5LJA7|uniprotkb:Q8TBS4|uniprotkb:Q96BJ9|uniprotkb:Q9H1W5|uniprotkb:Q9P0I3|uniprotkb:Q9UQN2|ensembl:ENSP00000356425 intact:EBI-357669|uniprotkb:Q92524|uniprotkb:P49719|uniprotkb:Q6IBU3|uniprotkb:B2R975|ensembl:ENSP00000401802 psi-mi:uchl5_human(display_long)|uniprotkb:Ubiquitin thioesterase L5(gene name synonym)|uniprotkb:Ubiquitin C-terminal hydrolase UCH37(gene name synonym)|uniprotkb:UCHL5(gene name)|psi-mi:UCHL5(display_short)|uniprotkb:UCH37(gene name synonym)|uniprotkb:AD-019(orf name)|uniprotkb:CGI-70(orf name) psi-mi:prs10_human(display_long)|uniprotkb:PSMC6(gene name)|psi-mi:PSMC6(display_short)|uniprotkb:SUG2(gene name synonym)|uniprotkb:Proteasome 26S subunit ATPase 6(gene name synonym)|uniprotkb:Proteasome subunit p42(gene name synonym)|uniprotkb:26S proteasome AAA-ATPase subunit RPT4(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511218|imex:IM-12079-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001186190.1|refseq:NP_001186191.1|refseq:NP_001186192.1|refseq:NP_057068.1|ensembl:ENSG00000116750(gene)|ensembl:ENST00000367455(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0021670"(lateral ventricle development)|go:"GO:0030901"(midbrain development)|go:"GO:0031011"(Ino80 complex)|go:"GO:0031597"(cytosolic proteasome complex)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0048853"(forebrain morphogenesis)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070628"(proteasome binding)|interpro:IPR001578(Peptidase C12, ubiquitin carboxyl-terminal hydrolase 1)|interpro:IPR017390(Ubiquitinyl hydrolase, UCH37 type)|interpro:IPR033837|interpro:IPR036959|interpro:IPR038765|interpro:IPR041507|mint:Q9Y5K5|rcsb pdb:3A7S|rcsb pdb:3IHR|rcsb pdb:3RII|rcsb pdb:3RIS|rcsb pdb:3TB3|rcsb pdb:4UEL|rcsb pdb:4UEM|rcsb pdb:4UF5|rcsb pdb:4UF6|rcsb pdb:4WLP|reactome:R-HSA-2173788|reactome:R-HSA-5689603|dip:DIP-42671N refseq:NP_002797.3|ensembl:ENST00000445930(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|ensembl:ENSG00000100519(gene)|go:"GO:0005829"(cytosol)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031597"(cytosolic proteasome complex)|go:"GO:0036402"(proteasome-activating activity)|go:"GO:0042802"(identical protein binding)|interpro:IPR032501|interpro:IPR035263|interpro:IPR041569|mint:P62333|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4G|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VGZ|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHJ|rcsb pdb:5VHM|rcsb pdb:5VHN|rcsb pdb:5VHO|rcsb pdb:5VHP|rcsb pdb:5VHQ|rcsb pdb:5VHR|rcsb pdb:5VHS|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6WJN|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|go:"GO:0045899"(positive regulation of RNA polymerase II transcription preinitiation complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090261"(positive regulation of inclusion body assembly)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR005937(26S proteasome subunit P45)|interpro:IPR027417|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|reactome:R-HSA-75815|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-174184|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|dip:DIP-38150N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:gRm5ttq5Tc0cBIOQ1ut2ugzbMTY9606 rogid:QE8jzSEp1bpzhOi/oAAnV18QK249606 intact-crc:8048E4F3002361C1|rigid:5TE1CyyNtrgsGHuW/ZDbdWfMAUQ false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y5K5 uniprotkb:O00232 intact:EBI-1051183|uniprotkb:Q5LJA6|uniprotkb:Q5LJA7|uniprotkb:Q8TBS4|uniprotkb:Q96BJ9|uniprotkb:Q9H1W5|uniprotkb:Q9P0I3|uniprotkb:Q9UQN2|ensembl:ENSP00000356425 intact:EBI-359733|uniprotkb:Q53HA2|uniprotkb:Q6P053|ensembl:ENSP00000348442|uniprotkb:A6NP15 psi-mi:uchl5_human(display_long)|uniprotkb:Ubiquitin thioesterase L5(gene name synonym)|uniprotkb:Ubiquitin C-terminal hydrolase UCH37(gene name synonym)|uniprotkb:UCHL5(gene name)|psi-mi:UCHL5(display_short)|uniprotkb:UCH37(gene name synonym)|uniprotkb:AD-019(orf name)|uniprotkb:CGI-70(orf name) psi-mi:psd12_human(display_long)|uniprotkb:PSMD12(gene name)|psi-mi:PSMD12(display_short)|uniprotkb:26S proteasome regulatory subunit p55(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN5(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511218|imex:IM-12079-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001186190.1|refseq:NP_001186191.1|refseq:NP_001186192.1|refseq:NP_057068.1|ensembl:ENSG00000116750(gene)|ensembl:ENST00000367455(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0021670"(lateral ventricle development)|go:"GO:0030901"(midbrain development)|go:"GO:0031011"(Ino80 complex)|go:"GO:0031597"(cytosolic proteasome complex)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0048853"(forebrain morphogenesis)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070628"(proteasome binding)|interpro:IPR001578(Peptidase C12, ubiquitin carboxyl-terminal hydrolase 1)|interpro:IPR017390(Ubiquitinyl hydrolase, UCH37 type)|interpro:IPR033837|interpro:IPR036959|interpro:IPR038765|interpro:IPR041507|mint:Q9Y5K5|rcsb pdb:3A7S|rcsb pdb:3IHR|rcsb pdb:3RII|rcsb pdb:3RIS|rcsb pdb:3TB3|rcsb pdb:4UEL|rcsb pdb:4UEM|rcsb pdb:4UF5|rcsb pdb:4UF6|rcsb pdb:4WLP|reactome:R-HSA-2173788|reactome:R-HSA-5689603|dip:DIP-42671N refseq:NP_002807.1|refseq:NP_001303270.1|ensembl:ENSG00000197170(gene)|ensembl:ENST00000356126(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0008541"(proteasome regulatory particle, lid subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0031595"(nuclear proteasome complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR035297|interpro:IPR036388|interpro:IPR036390|interpro:IPR040134|interpro:IPR040896|mint:O00232|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VGZ|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHS|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|rcsb pdb:5VFS|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-5687128|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|refseq:NP_777360.1|dip:DIP-27549N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:gRm5ttq5Tc0cBIOQ1ut2ugzbMTY9606 rogid:4tzcvfL/EqQRcUpoMtxVU0WC+TU9606 intact-crc:8048E4F3002361C1|rigid:5TE1CyyNtrgsGHuW/ZDbdWfMAUQ false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y5K5 uniprotkb:P51665 intact:EBI-1051183|uniprotkb:Q5LJA6|uniprotkb:Q5LJA7|uniprotkb:Q8TBS4|uniprotkb:Q96BJ9|uniprotkb:Q9H1W5|uniprotkb:Q9P0I3|uniprotkb:Q9UQN2|ensembl:ENSP00000356425 intact:EBI-357659|uniprotkb:Q6PKI2|uniprotkb:Q96E97|ensembl:ENSP00000219313|uniprotkb:D3DWS9 psi-mi:uchl5_human(display_long)|uniprotkb:Ubiquitin thioesterase L5(gene name synonym)|uniprotkb:Ubiquitin C-terminal hydrolase UCH37(gene name synonym)|uniprotkb:UCHL5(gene name)|psi-mi:UCHL5(display_short)|uniprotkb:UCH37(gene name synonym)|uniprotkb:AD-019(orf name)|uniprotkb:CGI-70(orf name) psi-mi:psmd7_human(display_long)|uniprotkb:PSMD7(gene name)|psi-mi:PSMD7(display_short)|uniprotkb:MOV34L(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN8(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S12(gene name synonym)|uniprotkb:Proteasome subunit p40(gene name synonym)|uniprotkb:Mov34 protein homolog(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511218|imex:IM-12079-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001186190.1|refseq:NP_001186191.1|refseq:NP_001186192.1|refseq:NP_057068.1|ensembl:ENSG00000116750(gene)|ensembl:ENST00000367455(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0021670"(lateral ventricle development)|go:"GO:0030901"(midbrain development)|go:"GO:0031011"(Ino80 complex)|go:"GO:0031597"(cytosolic proteasome complex)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0048853"(forebrain morphogenesis)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070628"(proteasome binding)|interpro:IPR001578(Peptidase C12, ubiquitin carboxyl-terminal hydrolase 1)|interpro:IPR017390(Ubiquitinyl hydrolase, UCH37 type)|interpro:IPR033837|interpro:IPR036959|interpro:IPR038765|interpro:IPR041507|mint:Q9Y5K5|rcsb pdb:3A7S|rcsb pdb:3IHR|rcsb pdb:3RII|rcsb pdb:3RIS|rcsb pdb:3TB3|rcsb pdb:4UEL|rcsb pdb:4UEM|rcsb pdb:4UF5|rcsb pdb:4UF6|rcsb pdb:4WLP|reactome:R-HSA-2173788|reactome:R-HSA-5689603|dip:DIP-42671N refseq:NP_002802.2|rcsb pdb:5T0J|ensembl:ENSG00000103035(gene)|ensembl:ENST00000219313(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0016020"(membrane)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070122"(isopeptidase activity)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR024969|interpro:IPR033858|interpro:IPR037518|mint:P51665|rcsb pdb:2O95|rcsb pdb:2O96|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VGZ|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHS|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-180534|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-195253|reactome:R-HSA-5676590|reactome:R-HSA-202424|reactome:R-HSA-5678895|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-2871837|reactome:R-HSA-5689880|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-6798695|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-68827|reactome:R-HSA-4641258|reactome:R-HSA-68949|reactome:R-HSA-5358346|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|dip:DIP-27572N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:gRm5ttq5Tc0cBIOQ1ut2ugzbMTY9606 rogid:HJaBTx4pIiSDIArqueuNRvhzVvU9606 intact-crc:8048E4F3002361C1|rigid:5TE1CyyNtrgsGHuW/ZDbdWfMAUQ false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y5K5 uniprotkb:Q6P4R8 intact:EBI-1051183|uniprotkb:Q5LJA6|uniprotkb:Q5LJA7|uniprotkb:Q8TBS4|uniprotkb:Q96BJ9|uniprotkb:Q9H1W5|uniprotkb:Q9P0I3|uniprotkb:Q9UQN2|ensembl:ENSP00000356425 intact:EBI-2511210|ensembl:ENSP00000400476|ensembl:ENSP00000433572|ensembl:ENSP00000506850|uniprotkb:Q12869|uniprotkb:Q9H048|uniprotkb:Q15312 psi-mi:uchl5_human(display_long)|uniprotkb:Ubiquitin thioesterase L5(gene name synonym)|uniprotkb:Ubiquitin C-terminal hydrolase UCH37(gene name synonym)|uniprotkb:UCHL5(gene name)|psi-mi:UCHL5(display_short)|uniprotkb:UCH37(gene name synonym)|uniprotkb:AD-019(orf name)|uniprotkb:CGI-70(orf name) psi-mi:nfrkb_human(display_long)|uniprotkb:NFRKB(gene name)|psi-mi:NFRKB(display_short)|uniprotkb:INO80G(gene name synonym)|uniprotkb:DNA-binding protein R kappa-B(gene name synonym)|uniprotkb:INO80 complex subunit G(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511218|imex:IM-12079-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001186190.1|refseq:NP_001186191.1|refseq:NP_001186192.1|refseq:NP_057068.1|ensembl:ENSG00000116750(gene)|ensembl:ENST00000367455(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0021670"(lateral ventricle development)|go:"GO:0030901"(midbrain development)|go:"GO:0031011"(Ino80 complex)|go:"GO:0031597"(cytosolic proteasome complex)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0048853"(forebrain morphogenesis)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070628"(proteasome binding)|interpro:IPR001578(Peptidase C12, ubiquitin carboxyl-terminal hydrolase 1)|interpro:IPR017390(Ubiquitinyl hydrolase, UCH37 type)|interpro:IPR033837|interpro:IPR036959|interpro:IPR038765|interpro:IPR041507|mint:Q9Y5K5|rcsb pdb:3A7S|rcsb pdb:3IHR|rcsb pdb:3RII|rcsb pdb:3RIS|rcsb pdb:3TB3|rcsb pdb:4UEL|rcsb pdb:4UEM|rcsb pdb:4UF5|rcsb pdb:4UF6|rcsb pdb:4WLP|reactome:R-HSA-2173788|reactome:R-HSA-5689603|dip:DIP-42671N ensembl:ENSG00000170322(gene)|ensembl:ENST00000446488(transcript)|ensembl:ENST00000524746(transcript)|ensembl:ENST00000682444(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0031011"(Ino80 complex)|interpro:IPR024867|interpro:IPR025220|interpro:IPR038106|interpro:IPR044867|mint:Q6P4R8|rcsb pdb:3U21|rcsb pdb:4UF5|rcsb pdb:4UF6|rcsb pdb:4WLP|reactome:R-HSA-5689603|reactome:R-HSA-5696394|refseq:XP_011541153.1|refseq:XP_011541154.1|refseq:NP_001137307.1|refseq:NP_006156.2|refseq:XP_016873285.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:gRm5ttq5Tc0cBIOQ1ut2ugzbMTY9606 rogid:3eKREgXAhhBBuj4ZcG0tm4Iar3g9606 intact-crc:8048E4F3002361C1|rigid:5TE1CyyNtrgsGHuW/ZDbdWfMAUQ false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y5K5 uniprotkb:Q13200 intact:EBI-1051183|uniprotkb:Q5LJA6|uniprotkb:Q5LJA7|uniprotkb:Q8TBS4|uniprotkb:Q96BJ9|uniprotkb:Q9H1W5|uniprotkb:Q9P0I3|uniprotkb:Q9UQN2|ensembl:ENSP00000356425 intact:EBI-357648|uniprotkb:B4DX07|uniprotkb:B4DXY1|uniprotkb:E7EW34|uniprotkb:E9PCS3|uniprotkb:Q12932|uniprotkb:Q15321|uniprotkb:Q96I12|ensembl:ENSP00000310129|uniprotkb:Q53XQ4 psi-mi:uchl5_human(display_long)|uniprotkb:Ubiquitin thioesterase L5(gene name synonym)|uniprotkb:Ubiquitin C-terminal hydrolase UCH37(gene name synonym)|uniprotkb:UCHL5(gene name)|psi-mi:UCHL5(display_short)|uniprotkb:UCH37(gene name synonym)|uniprotkb:AD-019(orf name)|uniprotkb:CGI-70(orf name) psi-mi:psmd2_human(display_long)|uniprotkb:PSMD2(gene name)|psi-mi:PSMD2(display_short)|uniprotkb:TRAP2(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN1(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S2(gene name synonym)|uniprotkb:26S proteasome subunit p97(gene name synonym)|uniprotkb:Tumor necrosis factor type 1 receptor-associated protein 2(gene name synonym)|uniprotkb:Protein 55.11(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511218|imex:IM-12079-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001186190.1|refseq:NP_001186191.1|refseq:NP_001186192.1|refseq:NP_057068.1|ensembl:ENSG00000116750(gene)|ensembl:ENST00000367455(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0021670"(lateral ventricle development)|go:"GO:0030901"(midbrain development)|go:"GO:0031011"(Ino80 complex)|go:"GO:0031597"(cytosolic proteasome complex)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0048853"(forebrain morphogenesis)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070628"(proteasome binding)|interpro:IPR001578(Peptidase C12, ubiquitin carboxyl-terminal hydrolase 1)|interpro:IPR017390(Ubiquitinyl hydrolase, UCH37 type)|interpro:IPR033837|interpro:IPR036959|interpro:IPR038765|interpro:IPR041507|mint:Q9Y5K5|rcsb pdb:3A7S|rcsb pdb:3IHR|rcsb pdb:3RII|rcsb pdb:3RIS|rcsb pdb:3TB3|rcsb pdb:4UEL|rcsb pdb:4UEM|rcsb pdb:4UF5|rcsb pdb:4UF6|rcsb pdb:4WLP|reactome:R-HSA-2173788|reactome:R-HSA-5689603|dip:DIP-42671N refseq:NP_001265637.1|refseq:NP_001265638.1|refseq:NP_002799.3|ensembl:ENSG00000175166(gene)|ensembl:ENST00000310118(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0034515"(proteasome storage granule)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR002015(Proteasome/cyclosome, regulatory subunit)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040892|interpro:IPR041433|mint:Q13200|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|interpro:IPR016643(26S proteasome regulatory complex, non-ATPase subcomplex, Rpn1 subunit)|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHJ|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|reactome:R-HSA-9010553|rcsb pdb:5VHM|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:5VHN|rcsb pdb:5VHO|rcsb pdb:5VHP|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:5VHQ|rcsb pdb:5VHR|rcsb pdb:5VHS|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|rcsb pdb:6MSB|rcsb pdb:6MSD|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-5668541|dip:DIP-38204N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:gRm5ttq5Tc0cBIOQ1ut2ugzbMTY9606 rogid:wujS1i4Gs3gWNinOey4oKsshA+g9606 intact-crc:8048E4F3002361C1|rigid:5TE1CyyNtrgsGHuW/ZDbdWfMAUQ false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y5K5 uniprotkb:P62191 intact:EBI-1051183|uniprotkb:Q5LJA6|uniprotkb:Q5LJA7|uniprotkb:Q8TBS4|uniprotkb:Q96BJ9|uniprotkb:Q9H1W5|uniprotkb:Q9P0I3|uniprotkb:Q9UQN2|ensembl:ENSP00000356425 intact:EBI-357598|uniprotkb:P49014|uniprotkb:Q03527|uniprotkb:Q6IAW0|uniprotkb:Q96AZ3|ensembl:ENSP00000261303|uniprotkb:Q6NW36|uniprotkb:B4DR63 psi-mi:uchl5_human(display_long)|uniprotkb:Ubiquitin thioesterase L5(gene name synonym)|uniprotkb:Ubiquitin C-terminal hydrolase UCH37(gene name synonym)|uniprotkb:UCHL5(gene name)|psi-mi:UCHL5(display_short)|uniprotkb:UCH37(gene name synonym)|uniprotkb:AD-019(orf name)|uniprotkb:CGI-70(orf name) psi-mi:prs4_human(display_long)|uniprotkb:PSMC1(gene name)|psi-mi:PSMC1(display_short)|uniprotkb:26S proteasome AAA-ATPase subunit RPT2(gene name synonym)|uniprotkb:Proteasome 26S subunit ATPase 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511218|imex:IM-12079-15 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001186190.1|refseq:NP_001186191.1|refseq:NP_001186192.1|refseq:NP_057068.1|ensembl:ENSG00000116750(gene)|ensembl:ENST00000367455(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0021670"(lateral ventricle development)|go:"GO:0030901"(midbrain development)|go:"GO:0031011"(Ino80 complex)|go:"GO:0031597"(cytosolic proteasome complex)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0048853"(forebrain morphogenesis)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070628"(proteasome binding)|interpro:IPR001578(Peptidase C12, ubiquitin carboxyl-terminal hydrolase 1)|interpro:IPR017390(Ubiquitinyl hydrolase, UCH37 type)|interpro:IPR033837|interpro:IPR036959|interpro:IPR038765|interpro:IPR041507|mint:Q9Y5K5|rcsb pdb:3A7S|rcsb pdb:3IHR|rcsb pdb:3RII|rcsb pdb:3RIS|rcsb pdb:3TB3|rcsb pdb:4UEL|rcsb pdb:4UEM|rcsb pdb:4UF5|rcsb pdb:4UF6|rcsb pdb:4WLP|reactome:R-HSA-2173788|reactome:R-HSA-5689603|dip:DIP-42671N refseq:NP_002793.2|ensembl:ENST00000261303(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0017025"(TBP-class protein binding)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0030163"(protein catabolic process)|ensembl:ENSG00000100764(gene)|go:"GO:0036402"(proteasome-activating activity)|go:"GO:1901215"(negative regulation of neuron death)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR005937(26S proteasome subunit P45)|interpro:IPR027417|interpro:IPR032501|interpro:IPR035244|interpro:IPR041569|mint:P62191|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4G|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFQ|rcsb pdb:5VFU|rcsb pdb:5VGZ|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHJ|rcsb pdb:5VHM|rcsb pdb:5VHN|rcsb pdb:5VHO|rcsb pdb:5VHP|rcsb pdb:5VHQ|rcsb pdb:5VHR|rcsb pdb:5VHS|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-532668|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-8852276|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|refseq:NP_001317141.1|refseq:XP_016876959.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:gRm5ttq5Tc0cBIOQ1ut2ugzbMTY9606 rogid:oGEtU7Cv0qversbD3WQgAo5H9pM9606 intact-crc:8048E4F3002361C1|rigid:5TE1CyyNtrgsGHuW/ZDbdWfMAUQ false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P51784 uniprotkb:Q92878 intact:EBI-306876|intact:EBI-1058416|uniprotkb:Q8IUG6|uniprotkb:Q9BWE1|uniprotkb:B2RTX1|ensembl:ENSP00000218348 intact:EBI-495494|uniprotkb:O43254|uniprotkb:Q6GMT7|uniprotkb:Q6P5X3|uniprotkb:Q9UP86|uniprotkb:B9EGF5|ensembl:ENSP00000368100 psi-mi:ubp11_human(display_long)|uniprotkb:USP11(gene name)|psi-mi:USP11(display_short)|uniprotkb:UHX1(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 11(gene name synonym)|uniprotkb:Deubiquitinating enzyme 11(gene name synonym)|uniprotkb:Ubiquitin thioesterase 11(gene name synonym) psi-mi:rad50_human(display_long)|uniprotkb:RAD50(gene name)|psi-mi:RAD50(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511298|imex:IM-12079-66 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000102226(gene)|ensembl:ENST00000218348(transcript)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR018200|interpro:IPR028135|interpro:IPR028889|interpro:IPR029346|interpro:IPR035927|interpro:IPR038765|mint:P51784|rcsb pdb:4MEL|rcsb pdb:5OK6|reactome:R-HSA-390471|reactome:R-HSA-5689880|refseq:NP_004642.2|refseq:XP_011542290.1|refseq:XP_005272731.1|dip:DIP-27567N refseq:NP_005723.2|dip:DIP-33606N|ensembl:ENSG00000113522(gene)|ensembl:ENST00000378823(transcript)|go:"GO:0000019"(regulation of mitotic recombination)|go:"GO:0000722"(telomere maintenance via recombination)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0003677"(DNA binding)|go:"GO:0003691"(double-stranded telomeric DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0016020"(membrane)|go:"GO:0016787"(hydrolase activity)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030870"(Mre11 complex)|go:"GO:0031860"(telomeric 3' overhang formation)|go:"GO:0031954"(positive regulation of protein autophosphorylation)|go:"GO:0032206"(positive regulation of telomere maintenance)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042802"(identical protein binding)|go:"GO:0043047"(single-stranded telomeric DNA binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051880"(G-quadruplex DNA binding)|go:"GO:0070192"(chromosome organization involved in meiotic cell cycle)|go:"GO:0090305"(nucleic acid phosphodiester bond hydrolysis)|go:"GO:1904354"(negative regulation of telomere capping)|interpro:IPR013134(Zinc hook, Rad50)|interpro:IPR027417|interpro:IPR038729|mint:Q92878|rcsb pdb:5GOX|reactome:R-HSA-2559586|reactome:R-HSA-5685938|reactome:R-HSA-5685939|reactome:R-HSA-5685942|reactome:R-HSA-5693548|reactome:R-HSA-5693554|reactome:R-HSA-5693565|reactome:R-HSA-5693568|reactome:R-HSA-5693571|reactome:R-HSA-5693579|reactome:R-HSA-5693607|reactome:R-HSA-5693616|reactome:R-HSA-6804756|reactome:R-HSA-69473|reactome:R-HSA-912446|interpro:IPR004584(Recombination/repair protein Rad50) psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2021/11/30 rogid:OSJLLFBf1ofw8SC01p2iiIM1oJo9606 rogid:yZsT5GcpA9HeFMoK4Jb1HYhrdKQ9606 intact-crc:F03843AD8CE15831|rigid:IMJbqoiSzxb7cKQYWRYWV8k10c0 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P51784 uniprotkb:O43166 intact:EBI-306876|intact:EBI-1058416|uniprotkb:Q8IUG6|uniprotkb:Q9BWE1|uniprotkb:B2RTX1|ensembl:ENSP00000218348 intact:EBI-310678|uniprotkb:O95321|uniprotkb:Q9UDU4|uniprotkb:Q9UNU4|intact:EBI-11025469|intact:EBI-28973250|uniprotkb:J3KP19|ensembl:ENSP00000450832 psi-mi:ubp11_human(display_long)|uniprotkb:USP11(gene name)|psi-mi:USP11(display_short)|uniprotkb:UHX1(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 11(gene name synonym)|uniprotkb:Deubiquitinating enzyme 11(gene name synonym)|uniprotkb:Ubiquitin thioesterase 11(gene name synonym) psi-mi:si1l1_human(display_long)|uniprotkb:SIPA1L1(gene name)|psi-mi:SIPA1L1(display_short)|uniprotkb:E6TP1(gene name synonym)|uniprotkb:KIAA0440(gene name synonym)|uniprotkb:High-risk human papilloma viruses E6 oncoproteins targeted protein 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511298|imex:IM-12079-66 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000102226(gene)|ensembl:ENST00000218348(transcript)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR018200|interpro:IPR028135|interpro:IPR028889|interpro:IPR029346|interpro:IPR035927|interpro:IPR038765|mint:P51784|rcsb pdb:4MEL|rcsb pdb:5OK6|reactome:R-HSA-390471|reactome:R-HSA-5689880|refseq:NP_004642.2|refseq:XP_011542290.1|refseq:XP_005272731.1|dip:DIP-27567N ensembl:ENST00000358550|ensembl:ENSP00000351352|ensembl:ENST00000381232|ensembl:ENSP00000370630|ensembl:ENSP00000450832|refseq:NP_001271174.1|refseq:NP_001271175.1|refseq:NP_056371.1|refseq:XP_005267573.1|refseq:XP_011534932.1|refseq:XP_011534933.1|refseq:XP_011534934.1|refseq:XP_011534937.1|refseq:XP_016876648.1|refseq:XP_016876649.1|refseq:XP_016876650.1|refseq:XP_016876651.1|refseq:XP_016876652.1|refseq:XP_016876653.1|refseq:XP_016876654.1|refseq:XP_016876655.1|refseq:XP_016876656.1|refseq:XP_016876657.1|refseq:XP_016876658.1|refseq:XP_016876659.1|refseq:XP_016876660.1|refseq:XP_016876661.1|refseq:XP_016876662.1|refseq:XP_016876663.1|refseq:XP_016876664.1|refseq:XP_016876665.1|refseq:XP_016876666.1|refseq:XP_016876667.1|refseq:XP_016876668.1|refseq:XP_016876669.1|refseq:XP_016876675.1|refseq:XP_016876676.1|refseq:XP_016876677.1|refseq:XP_016876678.1|refseq:XP_016876679.1|refseq:XP_016876680.1|refseq:XP_016876681.1|refseq:XP_016876682.1|ensembl:ENSG00000197555(gene)|ensembl:ENST00000555818(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043197"(dendritic spine)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0090630"(activation of GTPase activity)|interpro:IPR000331(Rap/ran-GAP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR021818|interpro:IPR030770|interpro:IPR035974|interpro:IPR036034|mint:O43166|reactome:R-HSA-6794361 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2021/11/30 rogid:OSJLLFBf1ofw8SC01p2iiIM1oJo9606 rogid:whpEjAhxfeYqeZ1IbjNl6romgXk9606 intact-crc:F03843AD8CE15831|rigid:IMJbqoiSzxb7cKQYWRYWV8k10c0 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P51784 uniprotkb:P0C2W1 intact:EBI-306876|intact:EBI-1058416|uniprotkb:Q8IUG6|uniprotkb:Q9BWE1|uniprotkb:B2RTX1|ensembl:ENSP00000218348 intact:EBI-2511355|ensembl:ENSP00000310332|uniprotkb:A6NF90|uniprotkb:D3DXB5 psi-mi:ubp11_human(display_long)|uniprotkb:USP11(gene name)|psi-mi:USP11(display_short)|uniprotkb:UHX1(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 11(gene name synonym)|uniprotkb:Deubiquitinating enzyme 11(gene name synonym)|uniprotkb:Ubiquitin thioesterase 11(gene name synonym) psi-mi:fbsp1_human(display_long)|uniprotkb:FBXO45(gene name)|psi-mi:FBXO45(display_short)|uniprotkb:FBX45(gene name synonym)|uniprotkb:F-box only protein 45(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511298|imex:IM-12079-66 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000102226(gene)|ensembl:ENST00000218348(transcript)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR018200|interpro:IPR028135|interpro:IPR028889|interpro:IPR029346|interpro:IPR035927|interpro:IPR038765|mint:P51784|rcsb pdb:4MEL|rcsb pdb:5OK6|reactome:R-HSA-390471|reactome:R-HSA-5689880|refseq:NP_004642.2|refseq:XP_011542290.1|refseq:XP_005272731.1|dip:DIP-27567N go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR035784|interpro:IPR036047|interpro:IPR043136|ensembl:ENSG00000174013(gene)|ensembl:ENST00000311630(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0021799"(cerebral cortex radially oriented cell migration)|go:"GO:0021800"(cerebral cortex tangential migration)|go:"GO:0021957"(corticospinal tract morphogenesis)|go:"GO:0021960"(anterior commissure morphogenesis)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042995"(cell projection)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0060386"(synapse assembly involved in innervation)|go:"GO:0098978"(glutamatergic synapse)|refseq:NP_001099043.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2021/11/30 rogid:OSJLLFBf1ofw8SC01p2iiIM1oJo9606 rogid:dr+dGdYmjZoA/fo7CyxhmLyWRLM9606 intact-crc:F03843AD8CE15831|rigid:IMJbqoiSzxb7cKQYWRYWV8k10c0 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P51784 uniprotkb:Q9BXB5 intact:EBI-306876|intact:EBI-1058416|uniprotkb:Q8IUG6|uniprotkb:Q9BWE1|uniprotkb:B2RTX1|ensembl:ENSP00000218348 intact:EBI-2511286|ensembl:ENSP00000379804|uniprotkb:Q9BTU5|uniprotkb:B4E212 psi-mi:ubp11_human(display_long)|uniprotkb:USP11(gene name)|psi-mi:USP11(display_short)|uniprotkb:UHX1(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 11(gene name synonym)|uniprotkb:Deubiquitinating enzyme 11(gene name synonym)|uniprotkb:Ubiquitin thioesterase 11(gene name synonym) psi-mi:osb10_human(display_long)|uniprotkb:OSBPL10(gene name)|psi-mi:OSBPL10(display_short)|uniprotkb:ORP10(gene name synonym)|uniprotkb:OSBP9(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511298|imex:IM-12079-66 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000102226(gene)|ensembl:ENST00000218348(transcript)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR018200|interpro:IPR028135|interpro:IPR028889|interpro:IPR029346|interpro:IPR035927|interpro:IPR038765|mint:P51784|rcsb pdb:4MEL|rcsb pdb:5OK6|reactome:R-HSA-390471|reactome:R-HSA-5689880|refseq:NP_004642.2|refseq:XP_011542290.1|refseq:XP_005272731.1|dip:DIP-27567N ensembl:ENSG00000144645(gene)|ensembl:ENST00000396556(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005548"(phospholipid transporter activity)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0015248"(sterol transporter activity)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016020"(membrane)|go:"GO:0032934"(sterol binding)|go:"GO:0036150"(phosphatidylserine acyl-chain remodeling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR000648(Oxysterol-binding protein)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR018494|interpro:IPR037239|interpro:IPR041680|reactome:R-HSA-1482801|refseq:NP_001167531.1|refseq:NP_060254.2 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2021/11/30 rogid:OSJLLFBf1ofw8SC01p2iiIM1oJo9606 rogid:1vbWq9QaTg7Nm56KJy7HKUoxWj49606 intact-crc:F03843AD8CE15831|rigid:IMJbqoiSzxb7cKQYWRYWV8k10c0 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P51784 uniprotkb:O95602 intact:EBI-306876|intact:EBI-1058416|uniprotkb:Q8IUG6|uniprotkb:Q9BWE1|uniprotkb:B2RTX1|ensembl:ENSP00000218348 intact:EBI-359472|uniprotkb:Q9UEH0|uniprotkb:Q9UFT9|uniprotkb:Q0VG05|uniprotkb:B7Z7T0|uniprotkb:D6W5M0|ensembl:ENSP00000263857 psi-mi:ubp11_human(display_long)|uniprotkb:USP11(gene name)|psi-mi:USP11(display_short)|uniprotkb:UHX1(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 11(gene name synonym)|uniprotkb:Deubiquitinating enzyme 11(gene name synonym)|uniprotkb:Ubiquitin thioesterase 11(gene name synonym) psi-mi:rpa1_human(display_long)|uniprotkb:POLR1A(gene name)|psi-mi:POLR1A(display_short)|uniprotkb:DNA-directed RNA polymerase I subunit A(gene name synonym)|uniprotkb:DNA-directed RNA polymerase I largest subunit(gene name synonym)|uniprotkb:RNA polymerase I 194 kDa subunit(gene name synonym)|uniprotkb:A190(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511298|imex:IM-12079-66 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000102226(gene)|ensembl:ENST00000218348(transcript)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR018200|interpro:IPR028135|interpro:IPR028889|interpro:IPR029346|interpro:IPR035927|interpro:IPR038765|mint:P51784|rcsb pdb:4MEL|rcsb pdb:5OK6|reactome:R-HSA-390471|reactome:R-HSA-5689880|refseq:NP_004642.2|refseq:XP_011542290.1|refseq:XP_005272731.1|dip:DIP-27567N refseq:NP_056240.2|ensembl:ENST00000263857(transcript)|go:"GO:0001054"(RNA polymerase I activity)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005736"(RNA polymerase I complex)|go:"GO:0008270"(zinc ion binding)|go:"GO:1904750"(negative regulation of protein localization to nucleolus)|interpro:IPR000722(RNA polymerase, alpha subunit)|interpro:IPR006592(RNA polymerase, N-terminal)|interpro:IPR007066(RNA polymerase Rpb1, domain 3)|interpro:IPR007080(RNA polymerase Rpb1, domain 1)|interpro:IPR007081(RNA polymerase Rpb1, domain 5)|interpro:IPR007083(RNA polymerase Rpb1, domain 4)|interpro:IPR015699(DNA-directed RNA pol I, largest subunit)|interpro:IPR038120|interpro:IPR042102|mint:O95602|reactome:R-HSA-427413|reactome:R-HSA-5250924|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73863|ensembl:ENSG00000068654(gene)|dip:DIP-27537N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2021/11/30 rogid:OSJLLFBf1ofw8SC01p2iiIM1oJo9606 rogid:EDNwLyujEW01bH48PD19pr3/lgU9606 intact-crc:F03843AD8CE15831|rigid:IMJbqoiSzxb7cKQYWRYWV8k10c0 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P51784 uniprotkb:Q8NC69 intact:EBI-306876|intact:EBI-1058416|uniprotkb:Q8IUG6|uniprotkb:Q9BWE1|uniprotkb:B2RTX1|ensembl:ENSP00000218348 intact:EBI-2511344|ensembl:ENSP00000347188|ensembl:ENSP00000384948|ensembl:ENSP00000417490|uniprotkb:Q8NBS6|uniprotkb:Q8TCA6|uniprotkb:B3KNI5 psi-mi:ubp11_human(display_long)|uniprotkb:USP11(gene name)|psi-mi:USP11(display_short)|uniprotkb:UHX1(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 11(gene name synonym)|uniprotkb:Deubiquitinating enzyme 11(gene name synonym)|uniprotkb:Ubiquitin thioesterase 11(gene name synonym) psi-mi:kctd6_human(display_long)|uniprotkb:KCTD6(gene name)|psi-mi:KCTD6(display_short)|uniprotkb:KCASH3 protein(gene name synonym)|uniprotkb:Potassium channel tetramerization domain-containing protein 6(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511298|imex:IM-12079-66 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000102226(gene)|ensembl:ENST00000218348(transcript)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR018200|interpro:IPR028135|interpro:IPR028889|interpro:IPR029346|interpro:IPR035927|interpro:IPR038765|mint:P51784|rcsb pdb:4MEL|rcsb pdb:5OK6|reactome:R-HSA-390471|reactome:R-HSA-5689880|refseq:NP_004642.2|refseq:XP_011542290.1|refseq:XP_005272731.1|dip:DIP-27567N interpro:IPR011333(BTB/POZ fold)|reactome:R-HSA-8931987|reactome:R-HSA-8951664|reactome:R-HSA-9018519|reactome:R-HSA-983168|ensembl:ENSG00000168301(gene)|ensembl:ENST00000355076(transcript)|ensembl:ENST00000404589(transcript)|ensembl:ENST00000490264(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031430"(M band)|go:"GO:0040008"(regulation of growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0097602"(cullin family protein binding)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR003131(Potassium channel, voltage dependent, Kv, tetramerisation)|refseq:NP_001121686.1|refseq:NP_699162.3|refseq:XP_005264994.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2021/11/30 rogid:OSJLLFBf1ofw8SC01p2iiIM1oJo9606 rogid:m2fVaYsVQ2wHfnYhxdgo1Q0J+TI9606 intact-crc:F03843AD8CE15831|rigid:IMJbqoiSzxb7cKQYWRYWV8k10c0 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P51784 uniprotkb:Q99550 intact:EBI-306876|intact:EBI-1058416|uniprotkb:Q8IUG6|uniprotkb:Q9BWE1|uniprotkb:B2RTX1|ensembl:ENSP00000218348 intact:EBI-2511359|intact:EBI-2809473|ensembl:ENSP00000475489|uniprotkb:U3KQ28|uniprotkb:Q9H976|uniprotkb:A6NEE2|uniprotkb:A1L486|uniprotkb:B3KR87 psi-mi:ubp11_human(display_long)|uniprotkb:USP11(gene name)|psi-mi:USP11(display_short)|uniprotkb:UHX1(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 11(gene name synonym)|uniprotkb:Deubiquitinating enzyme 11(gene name synonym)|uniprotkb:Ubiquitin thioesterase 11(gene name synonym) psi-mi:mpp9_human(display_long)|uniprotkb:MPHOSPH9(gene name)|psi-mi:MPHOSPH9(display_short)|uniprotkb:MPP9(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511298|imex:IM-12079-66 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000102226(gene)|ensembl:ENST00000218348(transcript)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR018200|interpro:IPR028135|interpro:IPR028889|interpro:IPR029346|interpro:IPR035927|interpro:IPR038765|mint:P51784|rcsb pdb:4MEL|rcsb pdb:5OK6|reactome:R-HSA-390471|reactome:R-HSA-5689880|refseq:NP_004642.2|refseq:XP_011542290.1|refseq:XP_005272731.1|dip:DIP-27567N ensembl:ENSG00000051825(gene)|ensembl:ENST00000606320(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005814"(centriole)|go:"GO:0016020"(membrane)|interpro:IPR026636|refseq:XP_016874162.1|refseq:XP_016874168.1|refseq:XP_016874169.1|refseq:NP_073619.3 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2021/11/30 rogid:OSJLLFBf1ofw8SC01p2iiIM1oJo9606 rogid:J1FkA3DERPWTHe57z9hMj6V52xI9606 intact-crc:F03843AD8CE15831|rigid:IMJbqoiSzxb7cKQYWRYWV8k10c0 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P51784 uniprotkb:O75390 intact:EBI-306876|intact:EBI-1058416|uniprotkb:Q8IUG6|uniprotkb:Q9BWE1|uniprotkb:B2RTX1|ensembl:ENSP00000218348 intact:EBI-487493|ensembl:ENSP00000342056|uniprotkb:Q71UT9|uniprotkb:Q7KZH0|uniprotkb:Q96FZ8|uniprotkb:Q9BWN8 psi-mi:ubp11_human(display_long)|uniprotkb:USP11(gene name)|psi-mi:USP11(display_short)|uniprotkb:UHX1(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 11(gene name synonym)|uniprotkb:Deubiquitinating enzyme 11(gene name synonym)|uniprotkb:Ubiquitin thioesterase 11(gene name synonym) psi-mi:cisy_human(display_long)|uniprotkb:CS(gene name)|psi-mi:CS(display_short)|uniprotkb:"Citrate (Si)-synthase"(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511298|imex:IM-12079-66 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000102226(gene)|ensembl:ENST00000218348(transcript)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR018200|interpro:IPR028135|interpro:IPR028889|interpro:IPR029346|interpro:IPR035927|interpro:IPR038765|mint:P51784|rcsb pdb:4MEL|rcsb pdb:5OK6|reactome:R-HSA-390471|reactome:R-HSA-5689880|refseq:NP_004642.2|refseq:XP_011542290.1|refseq:XP_005272731.1|dip:DIP-27567N go:"GO:0006101"(citrate metabolic process)|refseq:NP_004068.2|ensembl:ENSG00000062485(gene)|go:"GO:0004108"("citrate (Si)-synthase activity")|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0003723"(RNA binding)|ensembl:ENST00000351328(transcript)|rcsb pdb:5UZQ|rcsb pdb:5UZR|reactome:R-HSA-1268020|reactome:R-HSA-71403|go:"GO:0070062"(extracellular exosome)|interpro:IPR002020(Citrate synthase-like)|interpro:IPR010109(Citrate synthase, eukaryotic)|interpro:IPR016142(Citrate synthase-like, large alpha subdomain)|interpro:IPR016143(Citrate synthase-like, small alpha subdomain)|interpro:IPR019810|interpro:IPR036969|rcsb pdb:5UZP psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2021/11/30 rogid:OSJLLFBf1ofw8SC01p2iiIM1oJo9606 rogid:XKpnEsGOlGRNIAXMk4tTBH2okzo9606 intact-crc:F03843AD8CE15831|rigid:IMJbqoiSzxb7cKQYWRYWV8k10c0 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P51784 uniprotkb:Q9UM54 intact:EBI-306876|intact:EBI-1058416|uniprotkb:Q8IUG6|uniprotkb:Q9BWE1|uniprotkb:B2RTX1|ensembl:ENSP00000218348 intact:EBI-350606|uniprotkb:Q5TEM5|uniprotkb:Q5TEM6|uniprotkb:Q5TEM7|uniprotkb:Q9BZZ7|uniprotkb:Q9UEG2|uniprotkb:A6H8V4|uniprotkb:E1P540 psi-mi:ubp11_human(display_long)|uniprotkb:USP11(gene name)|psi-mi:USP11(display_short)|uniprotkb:UHX1(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 11(gene name synonym)|uniprotkb:Deubiquitinating enzyme 11(gene name synonym)|uniprotkb:Ubiquitin thioesterase 11(gene name synonym) psi-mi:myo6_human(display_long)|uniprotkb:MYO6(gene name)|psi-mi:MYO6(display_short)|uniprotkb:KIAA0389(gene name synonym)|uniprotkb:Unconventional myosin-6(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511298|imex:IM-12079-66 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000102226(gene)|ensembl:ENST00000218348(transcript)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR018200|interpro:IPR028135|interpro:IPR028889|interpro:IPR029346|interpro:IPR035927|interpro:IPR038765|mint:P51784|rcsb pdb:4MEL|rcsb pdb:5OK6|reactome:R-HSA-390471|reactome:R-HSA-5689880|refseq:NP_004642.2|refseq:XP_011542290.1|refseq:XP_005272731.1|dip:DIP-27567N go:"GO:0051046"(regulation of secretion)|refseq:NP_004990.3|go:"GO:0000146"(microfilament motor activity)|go:"GO:0001726"(ruffle)|go:"GO:0003774"(cytoskeletal motor activity)|go:"GO:0003779"(actin binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016461"(unconventional myosin complex)|go:"GO:0016591"(RNA polymerase II, holoenzyme)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0030050"(vesicle transport along actin filament)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030175"(filopodium)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0030665"(clathrin-coated vesicle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031941"(filamentous actin)|go:"GO:0031965"(nuclear membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032587"(ruffle membrane)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043531"(ADP binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051015"(actin filament binding)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005938"(cell cortex)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006897"(endocytosis)|go:"GO:0007015"(actin filament organization)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001609(Myosin head, motor region)|interpro:IPR004009(Myosin, N-terminal, SH3-like)|interpro:IPR008989(Myosin S1 fragment, N-terminal)|interpro:IPR027417|interpro:IPR032412|interpro:IPR036114|interpro:IPR036961|rcsb pdb:2N0Z|rcsb pdb:2N10|rcsb pdb:2N11|go:"GO:0060001"(minus-end directed microfilament motor activity)|rcsb pdb:2N12|rcsb pdb:2N13|rcsb pdb:6E5N|rcsb pdb:6J56|reactome:R-HSA-190873|reactome:R-HSA-399719|reactome:R-HSA-9013418|reactome:R-HSA-9013420|reactome:R-HSA-9013422|refseq:NP_001287828.1|mint:Q9UM54|dip:DIP-33123N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2021/11/30 rogid:OSJLLFBf1ofw8SC01p2iiIM1oJo9606 rogid:LYtnU7aRzVE/LDFhZgcK5IvahC09606 intact-crc:F03843AD8CE15831|rigid:IMJbqoiSzxb7cKQYWRYWV8k10c0 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P51784 uniprotkb:Q96HS1 intact:EBI-306876|intact:EBI-1058416|uniprotkb:Q8IUG6|uniprotkb:Q9BWE1|uniprotkb:B2RTX1|ensembl:ENSP00000218348 intact:EBI-713608|uniprotkb:Q96JB0|intact:EBI-2555528|ensembl:ENSP00000438465|uniprotkb:C9IZY7|uniprotkb:A9LN06 psi-mi:ubp11_human(display_long)|uniprotkb:USP11(gene name)|psi-mi:USP11(display_short)|uniprotkb:UHX1(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 11(gene name synonym)|uniprotkb:Deubiquitinating enzyme 11(gene name synonym)|uniprotkb:Ubiquitin thioesterase 11(gene name synonym) psi-mi:pgam5_human(display_long)|uniprotkb:Bcl-XL-binding protein v68(gene name synonym)|uniprotkb:PGAM5(gene name)|psi-mi:PGAM5(display_short)|uniprotkb:Phosphoglycerate mutase family member 5(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511298|imex:IM-12079-66 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000102226(gene)|ensembl:ENST00000218348(transcript)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR018200|interpro:IPR028135|interpro:IPR028889|interpro:IPR029346|interpro:IPR035927|interpro:IPR038765|mint:P51784|rcsb pdb:4MEL|rcsb pdb:5OK6|reactome:R-HSA-390471|reactome:R-HSA-5689880|refseq:NP_004642.2|refseq:XP_011542290.1|refseq:XP_005272731.1|dip:DIP-27567N refseq:NP_001164014.1|refseq:NP_612642.2|ensembl:ENSG00000247077(gene)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016236"(macroautophagy)|go:"GO:0016791"(phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0070266"(necroptotic process)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|interpro:IPR013078(Phosphoglycerate mutase)|interpro:IPR029033|mint:Q96HS1|rcsb pdb:3MXO|rcsb pdb:3O0T|rcsb pdb:5MUF|rcsb pdb:6CNI|rcsb pdb:6CNL|reactome:R-HSA-8934903|ensembl:ENST00000498926(transcript)|dip:DIP-50735N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2021/11/30 rogid:OSJLLFBf1ofw8SC01p2iiIM1oJo9606 rogid:prE0I+tNIEjN9Y1NBZbh51DY2+Q9606 intact-crc:F03843AD8CE15831|rigid:IMJbqoiSzxb7cKQYWRYWV8k10c0 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P51784 uniprotkb:O75592 intact:EBI-306876|intact:EBI-1058416|uniprotkb:Q8IUG6|uniprotkb:Q9BWE1|uniprotkb:B2RTX1|ensembl:ENSP00000218348 intact:EBI-1043774|uniprotkb:Q5JSX8|uniprotkb:Q5VZN6|uniprotkb:Q6PIB6|uniprotkb:Q9UQ11|uniprotkb:Q9Y6E4|uniprotkb:A6NJC6|ensembl:ENSP00000444596 psi-mi:ubp11_human(display_long)|uniprotkb:USP11(gene name)|psi-mi:USP11(display_short)|uniprotkb:UHX1(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 11(gene name synonym)|uniprotkb:Deubiquitinating enzyme 11(gene name synonym)|uniprotkb:Ubiquitin thioesterase 11(gene name synonym) psi-mi:mycb2_human(display_long)|uniprotkb:MYCBP2(gene name)|psi-mi:MYCBP2(display_short)|uniprotkb:KIAA0916(gene name synonym)|uniprotkb:PAM(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511298|imex:IM-12079-66 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000102226(gene)|ensembl:ENST00000218348(transcript)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR018200|interpro:IPR028135|interpro:IPR028889|interpro:IPR029346|interpro:IPR035927|interpro:IPR038765|mint:P51784|rcsb pdb:4MEL|rcsb pdb:5OK6|reactome:R-HSA-390471|reactome:R-HSA-5689880|refseq:NP_004642.2|refseq:XP_011542290.1|refseq:XP_005272731.1|dip:DIP-27567N refseq:NP_055872.4|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003646(Bacterial SH3-like region)|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR008979(Galactose-binding like)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR012983(PHR)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017868|interpro:IPR038648|mint:O75592|rcsb pdb:5O6C|rcsb pdb:6T7F|ensembl:ENSG00000005810(gene)|ensembl:ENST00000544440(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|dip:DIP-28142N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2021/11/30 rogid:OSJLLFBf1ofw8SC01p2iiIM1oJo9606 rogid:AR3FR/zd48HkVinEfdT17ItGkbU9606 intact-crc:F03843AD8CE15831|rigid:IMJbqoiSzxb7cKQYWRYWV8k10c0 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P51784 uniprotkb:Q6Y7W6 intact:EBI-306876|intact:EBI-1058416|uniprotkb:Q8IUG6|uniprotkb:Q9BWE1|uniprotkb:B2RTX1|ensembl:ENSP00000218348 intact:EBI-765394|uniprotkb:O75137|uniprotkb:Q7Z2Z8|uniprotkb:Q7Z3I2|uniprotkb:Q96HU4|uniprotkb:Q9NV82|uniprotkb:B9EG55|intact:EBI-10969943|uniprotkb:A6H8W4|uniprotkb:E9PBB0|ensembl:ENSP00000362664|ensembl:ENSP00000386537 psi-mi:ubp11_human(display_long)|uniprotkb:USP11(gene name)|psi-mi:USP11(display_short)|uniprotkb:UHX1(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 11(gene name synonym)|uniprotkb:Deubiquitinating enzyme 11(gene name synonym)|uniprotkb:Ubiquitin thioesterase 11(gene name synonym) psi-mi:ggyf2_human(display_long)|uniprotkb:Trinucleotide repeat-containing gene 15 protein(gene name synonym)|uniprotkb:GIGYF2(gene name)|psi-mi:GIGYF2(display_short)|uniprotkb:KIAA0642(gene name synonym)|uniprotkb:TNRC15(gene name synonym)|uniprotkb:PERQ2(gene name synonym)|uniprotkb:PERQ amino acid-rich with GYF domain-containing protein 2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511298|imex:IM-12079-66 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000102226(gene)|ensembl:ENST00000218348(transcript)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR018200|interpro:IPR028135|interpro:IPR028889|interpro:IPR029346|interpro:IPR035927|interpro:IPR038765|mint:P51784|rcsb pdb:4MEL|rcsb pdb:5OK6|reactome:R-HSA-390471|reactome:R-HSA-5689880|refseq:NP_004642.2|refseq:XP_011542290.1|refseq:XP_005272731.1|dip:DIP-27567N refseq:NP_001096616.1|refseq:NP_056390.2|refseq:NP_001096617.1|refseq:NP_001096618.1|ensembl:ENSG00000204120(gene)|ensembl:ENST00000373563(transcript)|ensembl:ENST00000409547(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005768"(endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0007631"(feeding behavior)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016441"(posttranscriptional gene silencing)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0021522"(spinal cord motor neuron differentiation)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0031982"(vesicle)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0043204"(perikaryon)|go:"GO:0044267"(cellular protein metabolic process)|go:"GO:0045296"(cadherin binding)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0050881"(musculoskeletal movement)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0061157"(mRNA destabilization)|go:"GO:0070064"(proline-rich region binding)|go:"GO:1990635"(proximal dendrite)|interpro:IPR003169(GYF)|interpro:IPR035445|rcsb pdb:5NVL|rcsb pdb:5NVM|mint:Q6Y7W6 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2021/11/30 rogid:OSJLLFBf1ofw8SC01p2iiIM1oJo9606 rogid:LCnAT/BvynGfhb1p3KMftXk8S3Q9606 intact-crc:F03843AD8CE15831|rigid:IMJbqoiSzxb7cKQYWRYWV8k10c0 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P51784 uniprotkb:Q9Y2D8 intact:EBI-306876|intact:EBI-1058416|uniprotkb:Q8IUG6|uniprotkb:Q9BWE1|uniprotkb:B2RTX1|ensembl:ENSP00000218348 intact:EBI-2212028|uniprotkb:B4DFE3|uniprotkb:J3KR02|uniprotkb:A8K8W0|uniprotkb:D3DT13|uniprotkb:Q6P2P8|uniprotkb:Q6ULS1|uniprotkb:Q7L168|uniprotkb:Q9UIX0|intact:EBI-10964529|ensembl:ENSP00000340279 psi-mi:ubp11_human(display_long)|uniprotkb:USP11(gene name)|psi-mi:USP11(display_short)|uniprotkb:UHX1(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 11(gene name synonym)|uniprotkb:Deubiquitinating enzyme 11(gene name synonym)|uniprotkb:Ubiquitin thioesterase 11(gene name synonym) psi-mi:adip_human(display_long)|uniprotkb:SSX2IP(gene name)|psi-mi:SSX2IP(display_short)|uniprotkb:KIAA0923(gene name synonym)|uniprotkb:Afadin DIL domain-interacting protein(gene name synonym)|uniprotkb:SSX2-interacting protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511298|imex:IM-12079-66 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000102226(gene)|ensembl:ENST00000218348(transcript)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR018200|interpro:IPR028135|interpro:IPR028889|interpro:IPR029346|interpro:IPR035927|interpro:IPR038765|mint:P51784|rcsb pdb:4MEL|rcsb pdb:5OK6|reactome:R-HSA-390471|reactome:R-HSA-5689880|refseq:NP_004642.2|refseq:XP_011542290.1|refseq:XP_005272731.1|dip:DIP-27567N refseq:XP_011538912.1|refseq:NP_001159765.1|refseq:NP_001159766.1|refseq:NP_001159767.1|refseq:NP_001159889.1|refseq:NP_054740.3|refseq:XP_005270484.1|refseq:XP_005270485.1|refseq:XP_006710394.1|refseq:XP_016855723.1|ensembl:ENSG00000117155(gene)|ensembl:ENST00000342203(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005912"(adherens junction)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007155"(cell adhesion)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031252"(cell leading edge)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034451"(centriolar satellite)|go:"GO:0035020"(regulation of Rac protein signal transduction)|go:"GO:0035735"(intraciliary transport involved in cilium assembly)|go:"GO:0036064"(ciliary basal body)|go:"GO:0060271"(cilium assembly)|go:"GO:2000145"(regulation of cell motility)|interpro:IPR021622|mint:Q9Y2D8 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2021/11/30 rogid:OSJLLFBf1ofw8SC01p2iiIM1oJo9606 rogid:E0VeMRF9SrpQKSJFP01XEbMjeF89606 intact-crc:F03843AD8CE15831|rigid:IMJbqoiSzxb7cKQYWRYWV8k10c0 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P51784 uniprotkb:P61619 intact:EBI-306876|intact:EBI-1058416|uniprotkb:Q8IUG6|uniprotkb:Q9BWE1|uniprotkb:B2RTX1|ensembl:ENSP00000218348 intact:EBI-358919|uniprotkb:Q5JPF8|uniprotkb:P38378|uniprotkb:P57726|uniprotkb:Q8N3U3|uniprotkb:Q8NC71|uniprotkb:Q9BU16|uniprotkb:Q9Y2R3|uniprotkb:Q8N0Z4|ensembl:ENSP00000243253 psi-mi:ubp11_human(display_long)|uniprotkb:USP11(gene name)|psi-mi:USP11(display_short)|uniprotkb:UHX1(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 11(gene name synonym)|uniprotkb:Deubiquitinating enzyme 11(gene name synonym)|uniprotkb:Ubiquitin thioesterase 11(gene name synonym) psi-mi:s61a1_human(display_long)|uniprotkb:SEC61A1(gene name)|psi-mi:SEC61A1(display_short)|uniprotkb:SEC61A(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511298|imex:IM-12079-66 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000102226(gene)|ensembl:ENST00000218348(transcript)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR018200|interpro:IPR028135|interpro:IPR028889|interpro:IPR029346|interpro:IPR035927|interpro:IPR038765|mint:P51784|rcsb pdb:4MEL|rcsb pdb:5OK6|reactome:R-HSA-390471|reactome:R-HSA-5689880|refseq:NP_004642.2|refseq:XP_011542290.1|refseq:XP_005272731.1|dip:DIP-27567N refseq:NP_037468.1|ensembl:ENSG00000058262(gene)|ensembl:ENST00000243253(transcript)|go:"GO:0005048"(signal sequence binding)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005784"(Sec61 translocon complex)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006613"(cotranslational protein targeting to membrane)|go:"GO:0006614"(SRP-dependent cotranslational protein targeting to membrane)|go:"GO:0006616"(SRP-dependent cotranslational protein targeting to membrane, translocation)|go:"GO:0006620"(posttranslational protein targeting to endoplasmic reticulum membrane)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0008320"(protein transmembrane transporter activity)|go:"GO:0016020"(membrane)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0031204"(posttranslational protein targeting to membrane, translocation)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0039019"(pronephric nephron development)|go:"GO:0043022"(ribosome binding)|go:"GO:0045047"(protein targeting to ER)|interpro:IPR002208(SecY protein)|interpro:IPR019561|interpro:IPR023201|interpro:IPR030659|mint:P61619|rcsb pdb:6W6L|reactome:R-HSA-1236974|reactome:R-HSA-1799339 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2021/11/30 rogid:OSJLLFBf1ofw8SC01p2iiIM1oJo9606 rogid:C+EzS02H/FYMX2nyfksXpRMs8G09606 intact-crc:F03843AD8CE15831|rigid:IMJbqoiSzxb7cKQYWRYWV8k10c0 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P51784 uniprotkb:P04637 intact:EBI-306876|intact:EBI-1058416|uniprotkb:Q8IUG6|uniprotkb:Q9BWE1|uniprotkb:B2RTX1|ensembl:ENSP00000218348 intact:EBI-366083|uniprotkb:Q15086|uniprotkb:Q15087|uniprotkb:Q15088|uniprotkb:Q16535|uniprotkb:Q16807|uniprotkb:Q16808|uniprotkb:Q16809|uniprotkb:Q16810|uniprotkb:Q16811|uniprotkb:Q16848|uniprotkb:Q86UG1|uniprotkb:Q8J016|uniprotkb:Q99659|uniprotkb:Q9BTM4|uniprotkb:Q9HAQ8|uniprotkb:Q9NP68|uniprotkb:Q9NPJ2|uniprotkb:Q9NZD0|uniprotkb:Q9UBI2|uniprotkb:Q9UQ61|ensembl:ENSP00000269305|ensembl:ENSP00000391478|intact:EBI-28980681|uniprotkb:Q2XN98|uniprotkb:Q3LRW1|uniprotkb:Q3LRW2|uniprotkb:Q3LRW3|uniprotkb:Q3LRW4|uniprotkb:Q3LRW5 psi-mi:ubp11_human(display_long)|uniprotkb:USP11(gene name)|psi-mi:USP11(display_short)|uniprotkb:UHX1(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 11(gene name synonym)|uniprotkb:Deubiquitinating enzyme 11(gene name synonym)|uniprotkb:Ubiquitin thioesterase 11(gene name synonym) psi-mi:p53_human(display_long)|uniprotkb:TP53(gene name)|psi-mi:TP53(display_short)|uniprotkb:P53(gene name synonym)|uniprotkb:Tumor suppressor p53(gene name synonym)|uniprotkb:Phosphoprotein p53(gene name synonym)|uniprotkb:Antigen NY-CO-13(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511298|imex:IM-12079-66 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000102226(gene)|ensembl:ENST00000218348(transcript)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR018200|interpro:IPR028135|interpro:IPR028889|interpro:IPR029346|interpro:IPR035927|interpro:IPR038765|mint:P51784|rcsb pdb:4MEL|rcsb pdb:5OK6|reactome:R-HSA-390471|reactome:R-HSA-5689880|refseq:NP_004642.2|refseq:XP_011542290.1|refseq:XP_005272731.1|dip:DIP-27567N refseq:NP_001263624.1|refseq:NP_001263625.1|ensembl:ENSG00000141510(gene)|ensembl:ENST00000269305(transcript)|ensembl:ENST00000445888(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0001094"(TFIID-class transcription factor complex binding)|go:"GO:0001216"(DNA-binding transcription activator activity)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001756"(somitogenesis)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0002020"(protease binding)|go:"GO:0002039"(p53 binding)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002309"(T cell proliferation involved in immune response)|go:"GO:0002360"(T cell lineage commitment)|go:"GO:0002326"(B cell lineage commitment)|go:"GO:0031497"(chromatin assembly)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034103"(regulation of tissue remodeling)|go:"GO:0034613"(cellular protein localization)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035033"(histone deacetylase regulator activity)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035690"|go:"GO:0035794"(positive regulation of mitochondrial membrane permeability)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036003"(positive regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0036310"(ATP-dependent DNA/DNA annealing activity)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0002931"(response to ischemia)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006914"(autophagy)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006977"(DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)|go:"GO:0006978"(DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator)|go:"GO:0006983"(ER overload response)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007369"(gastrulation)|go:"GO:0007406"(negative regulation of neuroblast proliferation)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0043504"(mitochondrial DNA repair)|go:"GO:0043516"(regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0043621"(protein self-association)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045899"(positive regulation of RNA polymerase II transcription preinitiation complex assembly)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0048512"(circadian behavior)|go:"GO:0048539"(bone marrow development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051097"(negative regulation of helicase activity)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0062100"(positive regulation of programmed necrotic cell death)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0060411"(cardiac septum morphogenesis)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070245"(positive regulation of thymocyte apoptotic process)|go:"GO:0070266"(necroptotic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0071494"(cellular response to UV-C)|go:"GO:0072331"(signal transduction by p53 class mediator)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0072717"(cellular response to actinomycin D)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0090343"(positive regulation of cell aging)|go:"GO:0090399"(replicative senescence)|go:"GO:0090403"(oxidative stress-induced premature senescence)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0097252"(oligodendrocyte apoptotic process)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0140296"(general transcription initiation factor binding)|go:"GO:1900119"(positive regulation of execution phase of apoptosis)|go:"GO:1901525"(negative regulation of mitophagy)|go:"GO:1902108"(regulation of mitochondrial membrane permeability involved in apoptotic process)|go:"GO:1902253"(regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904024"(negative regulation of glucose catabolic process to lactate via pyruvate)|go:"GO:1905856"(negative regulation of pentose-phosphate shunt)|go:"GO:1990144"(intrinsic apoptotic signaling pathway in response to hypoxia)|go:"GO:1990248"(regulation of transcription from RNA polymerase II promoter in response to DNA damage)|go:"GO:1990440"(positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000269"(regulation of fibroblast apoptotic process)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000772"(regulation of cellular senescence)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002117(p53 tumor antigen)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR010991(p53, tetramerisation)|interpro:IPR011615(p53, DNA-binding)|go:"GO:0007569"(cell aging)|go:"GO:0008104"(protein localization)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008156"(negative regulation of DNA replication)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009299"(mRNA transcription)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009651"(response to salt stress)|go:"GO:0010165"(response to X-ray)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0016032"(viral process)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016605"(PML body)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031065"(positive regulation of histone deacetylation)|interpro:IPR012346(p53 and RUNT-type transcription factor, DNA-binding)|interpro:IPR013872("p53 transactivation domain (TAD)")|interpro:IPR036674|interpro:IPR040926|rcsb pdb:2ATA|rcsb pdb:2B3G|rcsb pdb:2BIM|rcsb pdb:2BIN|rcsb pdb:2BIO|rcsb pdb:2BIP|rcsb pdb:2AHI|rcsb pdb:2BIQ|rcsb pdb:2F1X|rcsb pdb:2FEJ|rcsb pdb:2FOJ|rcsb pdb:2FOO|rcsb pdb:2GS0|rcsb pdb:2H1L|rcsb pdb:2H2D|rcsb pdb:2H2F|rcsb pdb:2H4F|rcsb pdb:2H4H|rcsb pdb:2H4J|rcsb pdb:2H59|rcsb pdb:2J0Z|rcsb pdb:2J10|rcsb pdb:2J11|rcsb pdb:2J1W|rcsb pdb:2J1X|rcsb pdb:2J1Y|rcsb pdb:2J1Z|rcsb pdb:2J20|rcsb pdb:2J21|rcsb pdb:2K8F|rcsb pdb:2L14|rcsb pdb:2LY4|rcsb pdb:2MEJ|rcsb pdb:2MWO|rcsb pdb:2MWP|rcsb pdb:2MWY|rcsb pdb:2MZD|rcsb pdb:2OCJ|rcsb pdb:2PCX|rcsb pdb:1A1U|rcsb pdb:1AIE|rcsb pdb:1C26|rcsb pdb:1DT7|rcsb pdb:1GZH|rcsb pdb:1H26|rcsb pdb:1HS5|rcsb pdb:1JSP|rcsb pdb:1KZY|rcsb pdb:1MA3|rcsb pdb:1OLG|rcsb pdb:1OLH|rcsb pdb:1PES|rcsb pdb:1PET|mint:P04637|rcsb pdb:1SAE|rcsb pdb:1SAF|rcsb pdb:1SAK|rcsb pdb:1SAL|rcsb pdb:1TSR|rcsb pdb:1TUP|rcsb pdb:1UOL|rcsb pdb:1XQH|rcsb pdb:1YC5|rcsb pdb:1YCQ|rcsb pdb:1YCR|rcsb pdb:1YCS|rcsb pdb:2AC0|rcsb pdb:2ADY|refseq:NP_000537.3|refseq:NP_001119584.1|refseq:NP_001119585.1|refseq:NP_001119586.1|refseq:NP_001119587.1|refseq:NP_001119588.1|refseq:NP_001119589.1|rcsb pdb:2RUK|rcsb pdb:2VUK|rcsb pdb:3Q06|rcsb pdb:2WGX|rcsb pdb:2X0U|rcsb pdb:2X0V|rcsb pdb:2X0W|rcsb pdb:2XWR|rcsb pdb:2YBG|rcsb pdb:2YDR|rcsb pdb:2Z5S|rcsb pdb:2Z5T|rcsb pdb:3SAK|rcsb pdb:3D05|rcsb pdb:3D06|rcsb pdb:3D07|rcsb pdb:3D08|rcsb pdb:3D09|rcsb pdb:3D0A|rcsb pdb:3DAB|rcsb pdb:3DAC|rcsb pdb:3IGK|rcsb pdb:3IGL|rcsb pdb:3KMD|rcsb pdb:3TG5|rcsb pdb:3KZ8|rcsb pdb:3LW1|rcsb pdb:3OQ5|rcsb pdb:3PDH|rcsb pdb:3Q01|rcsb pdb:3Q05|rcsb pdb:3TS8|rcsb pdb:3ZME|rcsb pdb:4AGM|rcsb pdb:4AGN|rcsb pdb:4AGO|rcsb pdb:4AGP|rcsb pdb:4AGQ|rcsb pdb:4BUZ|rcsb pdb:4BV2|rcsb pdb:4HFZ|rcsb pdb:4HJE|rcsb pdb:4IBQ|rcsb pdb:4IBS|rcsb pdb:4IBT|rcsb pdb:4IBU|rcsb pdb:4IBV|rcsb pdb:4IBW|rcsb pdb:4IBY|rcsb pdb:4IBZ|rcsb pdb:4IJT|rcsb pdb:4KVP|rcsb pdb:4LO9|rcsb pdb:4LOE|rcsb pdb:4LOF|rcsb pdb:4MZI|rcsb pdb:4MZR|rcsb pdb:4QO1|rcsb pdb:4RP6|rcsb pdb:4RP7|rcsb pdb:4X34|rcsb pdb:4XR8|rcsb pdb:4ZZJ|rcsb pdb:5A7B|rcsb pdb:5AB9|rcsb pdb:5ABA|rcsb pdb:4AGL|rcsb pdb:5AOI|rcsb pdb:5AOJ|rcsb pdb:5AOK|rcsb pdb:5AOL|rcsb pdb:5AOM|rcsb pdb:6XRE|rcsb pdb:7BWN|rcsb pdb:7DHY|rcsb pdb:7DHZ|rcsb pdb:7EL4|reactome:R-HSA-111448|reactome:R-HSA-139915|reactome:R-HSA-1912408|reactome:R-HSA-2559580|reactome:R-HSA-2559584|reactome:R-HSA-2559585|reactome:R-HSA-2559586|reactome:R-HSA-3232118|reactome:R-HSA-349425|reactome:R-HSA-390471|reactome:R-HSA-5620971|reactome:R-HSA-5628897|reactome:R-HSA-5689880|reactome:R-HSA-5689896|reactome:R-HSA-5693565|reactome:R-HSA-6785807|reactome:R-HSA-6796648|reactome:R-HSA-6803204|reactome:R-HSA-6803205|reactome:R-HSA-6803207|reactome:R-HSA-6803211|reactome:R-HSA-6804114|reactome:R-HSA-6804115|reactome:R-HSA-6804116|reactome:R-HSA-6804754|reactome:R-HSA-6804756|reactome:R-HSA-6804757|reactome:R-HSA-6804758|reactome:R-HSA-6804759|reactome:R-HSA-6804760|reactome:R-HSA-6811555|reactome:R-HSA-69473|reactome:R-HSA-69481|reactome:R-HSA-69541|reactome:R-HSA-69895|reactome:R-HSA-8852276|reactome:R-HSA-8853884|reactome:R-HSA-8941855|reactome:R-HSA-8943724|reactome:R-HSA-983231|rcsb pdb:5ECG|rcsb pdb:5G4M|rcsb pdb:5G4N|rcsb pdb:5BUA|rcsb pdb:5G4O|rcsb pdb:5HOU|rcsb pdb:5HP0|rcsb pdb:5HPD|rcsb pdb:5LAP|rcsb pdb:5LGY|rcsb pdb:5MCT|rcsb pdb:5MCU|rcsb pdb:5MCV|rcsb pdb:5MCW|rcsb pdb:5MF7|rcsb pdb:5MG7|rcsb pdb:5MHC|rcsb pdb:5MOC|rcsb pdb:5O1A|rcsb pdb:5O1B|rcsb pdb:5O1C|rcsb pdb:5O1D|rcsb pdb:5O1E|rcsb pdb:5O1F|rcsb pdb:5O1G|rcsb pdb:5O1H|rcsb pdb:5O1I|rcsb pdb:5OL0|rcsb pdb:5UN8|rcsb pdb:5XZC|rcsb pdb:6FF9|rcsb pdb:6FJ5|rcsb pdb:6GGA|rcsb pdb:6GGB|rcsb pdb:6GGC|rcsb pdb:6GGD|rcsb pdb:6GGE|rcsb pdb:6GGF|rcsb pdb:6LHD|rcsb pdb:6R5L|rcsb pdb:6RJZ|rcsb pdb:6RK8|rcsb pdb:6RKI|rcsb pdb:6RKK|rcsb pdb:6RKM|rcsb pdb:6RL3|rcsb pdb:6RL4|rcsb pdb:6RL6|rcsb pdb:6RM5|rcsb pdb:6RM7|rcsb pdb:6RWH|rcsb pdb:6RWI|rcsb pdb:6RWS|rcsb pdb:6RWU|rcsb pdb:6RX2|rcsb pdb:6RZ3|rcsb pdb:6S39|rcsb pdb:6S40|rcsb pdb:6S9Q|rcsb pdb:6SHZ|rcsb pdb:6SI0|rcsb pdb:6SI1|rcsb pdb:6SI2|rcsb pdb:6SI3|rcsb pdb:6SI4|rcsb pdb:6SIN|rcsb pdb:6SIO|rcsb pdb:6SIP|rcsb pdb:6SIQ|rcsb pdb:6SL6|rcsb pdb:6SLV|rcsb pdb:6T58|rcsb pdb:6V4F|rcsb pdb:6V4H|rcsb pdb:6VQO|rcsb pdb:6VR1|rcsb pdb:6VR5|rcsb pdb:6VRM|rcsb pdb:6VRN|rcsb pdb:6W51|rcsb pdb:6S3C|ensembl:ENSP00000269305|ensembl:ENST00000420246|ensembl:ENSP00000391127|ensembl:ENSP00000391478|ensembl:ENST00000455263|ensembl:ENSP00000398846|ensembl:ENST00000504290|ensembl:ENSP00000484409|ensembl:ENST00000504937|ensembl:ENSP00000481179|ensembl:ENST00000510385|ensembl:ENSP00000478499|ensembl:ENST00000610292|ensembl:ENSP00000478219|ensembl:ENST00000610538|ensembl:ENSP00000480868|ensembl:ENST00000619485|ensembl:ENSP00000482537|ensembl:ENST00000620739|ensembl:ENSP00000481638|ensembl:ENST00000622645|ensembl:ENSP00000482222|refseq:NP_001119590.1|refseq:NP_001263626.1|refseq:NP_001263627.1|refseq:NP_001263628.1|refseq:NP_001263689.1|refseq:NP_001263690.1|dip:DIP-368N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2021/11/30 rogid:OSJLLFBf1ofw8SC01p2iiIM1oJo9606 rogid:fGN3kSCGIpi/D6d/X5kaB0Xu8/k9606 intact-crc:F03843AD8CE15831|rigid:IMJbqoiSzxb7cKQYWRYWV8k10c0 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P51784 uniprotkb:Q13107 intact:EBI-306876|intact:EBI-1058416|uniprotkb:Q8IUG6|uniprotkb:Q9BWE1|uniprotkb:B2RTX1|ensembl:ENSP00000218348 intact:EBI-723290|uniprotkb:O43452|uniprotkb:O43453|uniprotkb:Q08AK8|ensembl:ENSP00000265560|uniprotkb:A8K6Y0|uniprotkb:C9IY91 psi-mi:ubp11_human(display_long)|uniprotkb:USP11(gene name)|psi-mi:USP11(display_short)|uniprotkb:UHX1(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 11(gene name synonym)|uniprotkb:Deubiquitinating enzyme 11(gene name synonym)|uniprotkb:Ubiquitin thioesterase 11(gene name synonym) psi-mi:ubp4_human(display_long)|uniprotkb:Ubiquitin-specific-processing protease 4(gene name synonym)|uniprotkb:Deubiquitinating enzyme 4(gene name synonym)|uniprotkb:Ubiquitous nuclear protein homolog(gene name synonym)|uniprotkb:USP4(gene name)|psi-mi:USP4(display_short)|uniprotkb:UNP(gene name synonym)|uniprotkb:UNPH(gene name synonym)|uniprotkb:Ubiquitin thioesterase 4(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511298|imex:IM-12079-66 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000102226(gene)|ensembl:ENST00000218348(transcript)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR018200|interpro:IPR028135|interpro:IPR028889|interpro:IPR029346|interpro:IPR035927|interpro:IPR038765|mint:P51784|rcsb pdb:4MEL|rcsb pdb:5OK6|reactome:R-HSA-390471|reactome:R-HSA-5689880|refseq:NP_004642.2|refseq:XP_011542290.1|refseq:XP_005272731.1|dip:DIP-27567N refseq:NP_003354.2|refseq:NP_955475.1|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031685"(adenosine receptor binding)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR018200|interpro:IPR028135|interpro:IPR028889|interpro:IPR035927|interpro:IPR038765|mint:Q13107|rcsb pdb:2Y6E|rcsb pdb:5CTR|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5689880|ensembl:ENSG00000114316(gene)|ensembl:ENST00000265560(transcript)|go:"GO:0000244"(spliceosomal tri-snRNP complex assembly)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0031397"(negative regulation of protein ubiquitination)|refseq:NP_001238806.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2021/11/30 rogid:OSJLLFBf1ofw8SC01p2iiIM1oJo9606 rogid:uVbfLYa5ruPa6HBQehcQfXqI22w9606 intact-crc:F03843AD8CE15831|rigid:IMJbqoiSzxb7cKQYWRYWV8k10c0 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P51784 uniprotkb:Q9Y285 intact:EBI-306876|intact:EBI-1058416|uniprotkb:Q8IUG6|uniprotkb:Q9BWE1|uniprotkb:B2RTX1|ensembl:ENSP00000218348 intact:EBI-725361|uniprotkb:Q9NSD8|uniprotkb:Q9Y4W8|uniprotkb:B4E363|ensembl:ENSP00000320309 psi-mi:ubp11_human(display_long)|uniprotkb:USP11(gene name)|psi-mi:USP11(display_short)|uniprotkb:UHX1(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 11(gene name synonym)|uniprotkb:Deubiquitinating enzyme 11(gene name synonym)|uniprotkb:Ubiquitin thioesterase 11(gene name synonym) psi-mi:syfa_human(display_long)|uniprotkb:CML33(gene name synonym)|uniprotkb:FARSA(gene name)|psi-mi:FARSA(display_short)|uniprotkb:FARS(gene name synonym)|uniprotkb:FARSLA(gene name synonym)|uniprotkb:FARSL(gene name synonym)|uniprotkb:Phenylalanyl-tRNA synthetase alpha subunit(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511298|imex:IM-12079-66 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000102226(gene)|ensembl:ENST00000218348(transcript)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR018200|interpro:IPR028135|interpro:IPR028889|interpro:IPR029346|interpro:IPR035927|interpro:IPR038765|mint:P51784|rcsb pdb:4MEL|rcsb pdb:5OK6|reactome:R-HSA-390471|reactome:R-HSA-5689880|refseq:NP_004642.2|refseq:XP_011542290.1|refseq:XP_005272731.1|dip:DIP-27567N refseq:NP_004452.1|ensembl:ENSG00000179115(gene)|ensembl:ENST00000314606(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004826"(phenylalanine-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006432"(phenylalanyl-tRNA aminoacylation)|go:"GO:0009328"(phenylalanine-tRNA ligase complex)|go:"GO:0016020"(membrane)|go:"GO:0051290"(protein heterotetramerization)|interpro:IPR002319(Phenylalanyl-tRNA synthetase, class IIc)|interpro:IPR004529(Phenylalanyl-tRNA synthetase, class IIc, alpha subunit)|interpro:IPR006195(Aminoacyl-tRNA synthetase, class II)|interpro:IPR036390|interpro:IPR040586|interpro:IPR040724|interpro:IPR040725|mint:Q9Y285|rcsb pdb:3L4G|reactome:R-HSA-379716|dip:DIP-53610N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2021/11/30 rogid:OSJLLFBf1ofw8SC01p2iiIM1oJo9606 rogid:FpOCk4Mzmsb2CnIUwUKg5nRg7/U9606 intact-crc:F03843AD8CE15831|rigid:IMJbqoiSzxb7cKQYWRYWV8k10c0 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P51784 uniprotkb:P23588 intact:EBI-306876|intact:EBI-1058416|uniprotkb:Q8IUG6|uniprotkb:Q9BWE1|uniprotkb:B2RTX1|ensembl:ENSP00000218348 intact:EBI-970310|ensembl:ENSP00000262056|uniprotkb:Q4G0E3|uniprotkb:Q53HQ2|uniprotkb:Q6GPH5|uniprotkb:Q6IB46|uniprotkb:Q8WYK5|uniprotkb:B4DS13 psi-mi:ubp11_human(display_long)|uniprotkb:USP11(gene name)|psi-mi:USP11(display_short)|uniprotkb:UHX1(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 11(gene name synonym)|uniprotkb:Deubiquitinating enzyme 11(gene name synonym)|uniprotkb:Ubiquitin thioesterase 11(gene name synonym) psi-mi:if4b_human(display_long)|uniprotkb:EIF4B(gene name)|psi-mi:EIF4B(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511298|imex:IM-12079-66 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000102226(gene)|ensembl:ENST00000218348(transcript)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR018200|interpro:IPR028135|interpro:IPR028889|interpro:IPR029346|interpro:IPR035927|interpro:IPR038765|mint:P51784|rcsb pdb:4MEL|rcsb pdb:5OK6|reactome:R-HSA-390471|reactome:R-HSA-5689880|refseq:NP_004642.2|refseq:XP_011542290.1|refseq:XP_005272731.1|dip:DIP-27567N ensembl:ENSG00000063046(gene)|ensembl:ENST00000262056(transcript)|go:"GO:0001731"(formation of translation preinitiation complex)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0016281"(eukaryotic translation initiation factor 4F complex)|go:"GO:0030425"(dendrite)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034057"(RNA strand-exchange activity)|go:"GO:0043024"(ribosomal small subunit binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0097010"(eukaryotic translation initiation factor 4F complex assembly)|go:"GO:0098794"(postsynapse)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR033107|interpro:IPR035979|mint:P23588|rcsb pdb:1WI8|rcsb pdb:2J76|rcsb pdb:6FEC|reactome:R-HSA-156827|reactome:R-HSA-166208|reactome:R-HSA-429947|reactome:R-HSA-72649|reactome:R-HSA-72662|reactome:R-HSA-72702|reactome:R-HSA-72706|refseq:NP_001408.2|refseq:NP_001317583.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2021/11/30 rogid:OSJLLFBf1ofw8SC01p2iiIM1oJo9606 rogid:6QlRkSj6suC5apkUxdZhOq+OMBc9606 intact-crc:F03843AD8CE15831|rigid:IMJbqoiSzxb7cKQYWRYWV8k10c0 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P51784 uniprotkb:Q14669 intact:EBI-306876|intact:EBI-1058416|uniprotkb:Q8IUG6|uniprotkb:Q9BWE1|uniprotkb:B2RTX1|ensembl:ENSP00000218348 intact:EBI-308443|uniprotkb:Q15644|ensembl:ENSP00000283943|uniprotkb:D4HL82|uniprotkb:Q14CA3|uniprotkb:Q14CF1|uniprotkb:Q53R87|uniprotkb:Q53TE7 psi-mi:ubp11_human(display_long)|uniprotkb:USP11(gene name)|psi-mi:USP11(display_short)|uniprotkb:UHX1(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 11(gene name synonym)|uniprotkb:Deubiquitinating enzyme 11(gene name synonym)|uniprotkb:Ubiquitin thioesterase 11(gene name synonym) psi-mi:tripc_human(display_long)|uniprotkb:TRIP12(gene name)|psi-mi:TRIP12(display_short)|uniprotkb:Thyroid receptor-interacting protein 12(gene name synonym)|uniprotkb:KIAA0045(gene name synonym)|uniprotkb:E3 ubiquitin-protein ligase for Arf(gene name synonym)|uniprotkb:ULF(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase TRIP12(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511298|imex:IM-12079-66 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000102226(gene)|ensembl:ENST00000218348(transcript)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR018200|interpro:IPR028135|interpro:IPR028889|interpro:IPR029346|interpro:IPR035927|interpro:IPR038765|mint:P51784|rcsb pdb:4MEL|rcsb pdb:5OK6|reactome:R-HSA-390471|reactome:R-HSA-5689880|refseq:NP_004642.2|refseq:XP_011542290.1|refseq:XP_005272731.1|dip:DIP-27567N refseq:NP_004229.1|refseq:NP_001271143.1|refseq:NP_001271144.1|refseq:NP_001271145.1|ensembl:ENSG00000153827(gene)|ensembl:ENST00000283943(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016607"(nuclear speck)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0046966"(thyroid hormone receptor binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1901315"(negative regulation of histone H2A K63-linked ubiquitination)|go:"GO:2000779"(regulation of double-strand break repair)|go:"GO:2000780"(negative regulation of double-strand break repair)|interpro:IPR000569(HECT)|interpro:IPR004170(WWE)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR035983|interpro:IPR037197|mint:Q14669|reactome:R-HSA-983168|refseq:NP_001335244.1|refseq:NP_001335245.1|ensembl:ENSP00000283943|ensembl:ENST00000389044|ensembl:ENST00000389045|ensembl:ENSP00000373697|ensembl:ENSP00000373696|dip:DIP-58584N psi-mi:"MI:0469"(intact) - caution:This sequence has been withdrawn from Uniprot.|crc64:294A7C063A3332DE figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2021/11/30 rogid:OSJLLFBf1ofw8SC01p2iiIM1oJo9606 rogid:wzXMKIUEDV4y7YE6PDU+LIPHl7U9606 intact-crc:F03843AD8CE15831|rigid:IMJbqoiSzxb7cKQYWRYWV8k10c0 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P51784 uniprotkb:P49959 intact:EBI-306876|intact:EBI-1058416|uniprotkb:Q8IUG6|uniprotkb:Q9BWE1|uniprotkb:B2RTX1|ensembl:ENSP00000218348 intact:EBI-396513|uniprotkb:O43475|uniprotkb:B3KTC7|ensembl:ENSP00000325863 psi-mi:ubp11_human(display_long)|uniprotkb:USP11(gene name)|psi-mi:USP11(display_short)|uniprotkb:UHX1(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 11(gene name synonym)|uniprotkb:Deubiquitinating enzyme 11(gene name synonym)|uniprotkb:Ubiquitin thioesterase 11(gene name synonym) psi-mi:mre11_human(display_long)|uniprotkb:MRE11(gene name)|psi-mi:MRE11(display_short)|uniprotkb:Double-strand break repair protein MRE11A(gene name synonym)|uniprotkb:HNGS1(gene name synonym)|uniprotkb:MRE11A(gene name synonym)|uniprotkb:Meiotic recombination 11 homolog 1(gene name synonym)|uniprotkb:Meiotic recombination 11 homolog A(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511298|imex:IM-12079-66 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000102226(gene)|ensembl:ENST00000218348(transcript)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR018200|interpro:IPR028135|interpro:IPR028889|interpro:IPR029346|interpro:IPR035927|interpro:IPR038765|mint:P51784|rcsb pdb:4MEL|rcsb pdb:5OK6|reactome:R-HSA-390471|reactome:R-HSA-5689880|refseq:NP_004642.2|refseq:XP_011542290.1|refseq:XP_005272731.1|dip:DIP-27567N refseq:NP_005581.2|refseq:NP_005582.1|refseq:XP_011541139.1|refseq:XP_016873261.1|dip:DIP-33238N|ensembl:ENSG00000020922(gene)|ensembl:ENST00000323929(transcript)|go:"GO:0000014"(single-stranded DNA endodeoxyribonuclease activity)|go:"GO:0000019"(regulation of mitotic recombination)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0004518"(nuclease activity)|go:"GO:0004520"(endodeoxyribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006310"(DNA recombination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0007129"(homologous chromosome pairing at meiosis)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008296"(3'-5'-exodeoxyribonuclease activity)|go:"GO:0008408"(3'-5' exonuclease activity)|go:"GO:0008409"(5'-3' exonuclease activity)|go:"GO:0016605"(PML body)|go:"GO:0030145"(manganese ion binding)|go:"GO:0030870"(Mre11 complex)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0031860"(telomeric 3' overhang formation)|go:"GO:0031954"(positive regulation of protein autophosphorylation)|go:"GO:0032206"(positive regulation of telomere maintenance)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042138"(meiotic DNA double-strand break formation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045296"(cadherin binding)|go:"GO:0097552"(mitochondrial double-strand break repair via homologous recombination)|go:"GO:0110025"(DNA strand resection involved in replication fork processing)|interpro:IPR003701(DNA repair exonuclease)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR007281(Mre11, DNA-binding)|interpro:IPR029052|interpro:IPR038487|interpro:IPR041796|mint:P49959|rcsb pdb:3T1I|reactome:R-HSA-1834949|reactome:R-HSA-2559586|reactome:R-HSA-3270619|reactome:R-HSA-5685938|reactome:R-HSA-5685939|reactome:R-HSA-5685942|reactome:R-HSA-5693548|reactome:R-HSA-5693554|reactome:R-HSA-5693565|reactome:R-HSA-5693568|reactome:R-HSA-5693571|reactome:R-HSA-5693579|reactome:R-HSA-5693607|reactome:R-HSA-5693616|reactome:R-HSA-6804756|reactome:R-HSA-69473|reactome:R-HSA-912446 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2021/11/30 rogid:OSJLLFBf1ofw8SC01p2iiIM1oJo9606 rogid:fgwgA0BcNZ9phGBaOSYjkldDgeI9606 intact-crc:F03843AD8CE15831|rigid:IMJbqoiSzxb7cKQYWRYWV8k10c0 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P51784 uniprotkb:Q14145 intact:EBI-306876|intact:EBI-1058416|uniprotkb:Q8IUG6|uniprotkb:Q9BWE1|uniprotkb:B2RTX1|ensembl:ENSP00000218348 intact:EBI-751001|uniprotkb:B3KPD5|uniprotkb:Q8WTX1|uniprotkb:Q6LEP0|uniprotkb:Q9BPY9|intact:EBI-28976014|ensembl:ENSP00000171111|ensembl:ENSP00000377245 psi-mi:ubp11_human(display_long)|uniprotkb:USP11(gene name)|psi-mi:USP11(display_short)|uniprotkb:UHX1(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 11(gene name synonym)|uniprotkb:Deubiquitinating enzyme 11(gene name synonym)|uniprotkb:Ubiquitin thioesterase 11(gene name synonym) psi-mi:keap1_human(display_long)|uniprotkb:Cytosolic inhibitor of Nrf2(gene name synonym)|uniprotkb:Kelch-like protein 19(gene name synonym)|uniprotkb:KEAP1(gene name)|psi-mi:KEAP1(display_short)|uniprotkb:INRF2(gene name synonym)|uniprotkb:KIAA0132(gene name synonym)|uniprotkb:KLHL19(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511298|imex:IM-12079-66 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000102226(gene)|ensembl:ENST00000218348(transcript)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR018200|interpro:IPR028135|interpro:IPR028889|interpro:IPR029346|interpro:IPR035927|interpro:IPR038765|mint:P51784|rcsb pdb:4MEL|rcsb pdb:5OK6|reactome:R-HSA-390471|reactome:R-HSA-5689880|refseq:NP_004642.2|refseq:XP_011542290.1|refseq:XP_005272731.1|dip:DIP-27567N refseq:NP_036421.2|refseq:NP_987096.1|ensembl:ENSP00000171111|ensembl:ENSP00000377245|refseq:XP_011526754.1|refseq:XP_005260230.1|refseq:XP_005260231.1|dip:DIP-42134N|ensembl:ENSG00000079999(gene)|ensembl:ENST00000171111(transcript)|ensembl:ENST00000393623(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016234"(inclusion body)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030496"(midbody)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0042802"(identical protein binding)|go:"GO:0042994"(cytoplasmic sequestering of transcription factor)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045604"(regulation of epidermal cell differentiation)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0097718"(disordered domain specific binding)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR011705(BTB/Kelch-associated)|interpro:IPR015915(Kelch-type beta propeller)|interpro:IPR017096(Kelch-like protein, gigaxonin)|interpro:IPR030563|mint:Q14145|rcsb pdb:1U6D|rcsb pdb:1ZGK|rcsb pdb:2FLU|rcsb pdb:3VNG|rcsb pdb:3VNH|rcsb pdb:3ZGC|rcsb pdb:3ZGD|rcsb pdb:4CXI|rcsb pdb:4CXJ|rcsb pdb:4CXT|rcsb pdb:4IFJ|rcsb pdb:4IFL|rcsb pdb:4IFN|rcsb pdb:4IN4|rcsb pdb:4IQK|rcsb pdb:4L7B|rcsb pdb:4L7C|rcsb pdb:4L7D|rcsb pdb:4N1B|rcsb pdb:4XMB|rcsb pdb:5DAD|rcsb pdb:5DAF|rcsb pdb:5F72|rcsb pdb:5GIT|rcsb pdb:5NLB|rcsb pdb:5WFL|rcsb pdb:5WFV|rcsb pdb:5WG1|rcsb pdb:5WHL|rcsb pdb:5WHO|rcsb pdb:5WIY|rcsb pdb:5X54|rcsb pdb:6FFM|rcsb pdb:6FMP|rcsb pdb:6FMQ|rcsb pdb:6HWS|rcsb pdb:6LRZ|rcsb pdb:6ROG|rcsb pdb:6SP1|rcsb pdb:6SP4|rcsb pdb:6T7V|rcsb pdb:6T7Z|rcsb pdb:6TG8|rcsb pdb:6TYM|rcsb pdb:6TYP|rcsb pdb:6UF0|rcsb pdb:6W66|rcsb pdb:6W67|rcsb pdb:6W68|rcsb pdb:6W69|rcsb pdb:6WCQ|rcsb pdb:6Z6A|rcsb pdb:7K28|rcsb pdb:7K29|rcsb pdb:7K2A|rcsb pdb:7K2B|rcsb pdb:7K2C|rcsb pdb:7K2D|rcsb pdb:7K2E|rcsb pdb:7K2F|rcsb pdb:7K2G|rcsb pdb:7K2H|rcsb pdb:7K2I|rcsb pdb:7K2J|rcsb pdb:7K2K|rcsb pdb:7K2L|rcsb pdb:7K2M|rcsb pdb:7K2N|rcsb pdb:7K2O|rcsb pdb:7K2P|rcsb pdb:7K2Q|rcsb pdb:7K2R|rcsb pdb:7K2S|reactome:R-HSA-5689880|reactome:R-HSA-8932339|reactome:R-HSA-8951664|reactome:R-HSA-983168|rcsb pdb:6V6Z psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2021/11/30 rogid:OSJLLFBf1ofw8SC01p2iiIM1oJo9606 rogid:3y/KqnUK+5nIyjhOEfkkthmP1OA9606 intact-crc:F03843AD8CE15831|rigid:IMJbqoiSzxb7cKQYWRYWV8k10c0 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P51784 uniprotkb:Q7Z628 intact:EBI-306876|intact:EBI-1058416|uniprotkb:Q8IUG6|uniprotkb:Q9BWE1|uniprotkb:B2RTX1|ensembl:ENSP00000218348 intact:EBI-2511306|ensembl:ENSP00000347134|uniprotkb:Q96D82|uniprotkb:Q99903|uniprotkb:Q9UEN6|uniprotkb:Q12773 psi-mi:ubp11_human(display_long)|uniprotkb:USP11(gene name)|psi-mi:USP11(display_short)|uniprotkb:UHX1(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 11(gene name synonym)|uniprotkb:Deubiquitinating enzyme 11(gene name synonym)|uniprotkb:Ubiquitin thioesterase 11(gene name synonym) psi-mi:arhg8_human(display_long)|uniprotkb:NET1(gene name)|psi-mi:NET1(display_short)|uniprotkb:ARHGEF8(gene name synonym)|uniprotkb:Proto-oncogene p65 Net1(gene name synonym)|uniprotkb:Rho guanine nucleotide exchange factor 8(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511298|imex:IM-12079-66 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000102226(gene)|ensembl:ENST00000218348(transcript)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR018200|interpro:IPR028135|interpro:IPR028889|interpro:IPR029346|interpro:IPR035927|interpro:IPR038765|mint:P51784|rcsb pdb:4MEL|rcsb pdb:5OK6|reactome:R-HSA-390471|reactome:R-HSA-5689880|refseq:NP_004642.2|refseq:XP_011542290.1|refseq:XP_005272731.1|dip:DIP-27567N ensembl:ENSG00000173848(gene)|ensembl:ENST00000355029(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0051451"(myoblast migration)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071479"(cellular response to ionizing radiation)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001849(Pleckstrin-like)|refseq:NP_001040625.1|refseq:NP_005854.2|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035899|interpro:IPR037853|rcsb pdb:3EO2|rcsb pdb:4XH9|reactome:R-HSA-193648|reactome:R-HSA-416482|reactome:R-HSA-8980692|reactome:R-HSA-9013026 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2021/11/30 rogid:OSJLLFBf1ofw8SC01p2iiIM1oJo9606 rogid:Fz61yRg9QxnNYHsRuDGvr3G0z8Y9606 intact-crc:F03843AD8CE15831|rigid:IMJbqoiSzxb7cKQYWRYWV8k10c0 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P51784 uniprotkb:Q5VV17 intact:EBI-306876|intact:EBI-1058416|uniprotkb:Q8IUG6|uniprotkb:Q9BWE1|uniprotkb:B2RTX1|ensembl:ENSP00000218348 intact:EBI-2510778|ensembl:ENSP00000365678 psi-mi:ubp11_human(display_long)|uniprotkb:USP11(gene name)|psi-mi:USP11(display_short)|uniprotkb:UHX1(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 11(gene name synonym)|uniprotkb:Deubiquitinating enzyme 11(gene name synonym)|uniprotkb:Ubiquitin thioesterase 11(gene name synonym) psi-mi:otud1_human(display_long)|uniprotkb:OTUD1(gene name)|psi-mi:OTUD1(display_short)|uniprotkb:DUBA7(gene name synonym)|uniprotkb:OTDC1(gene name synonym)|uniprotkb:DUBA-7(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511298|imex:IM-12079-66 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000102226(gene)|ensembl:ENST00000218348(transcript)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR018200|interpro:IPR028135|interpro:IPR028889|interpro:IPR029346|interpro:IPR035927|interpro:IPR038765|mint:P51784|rcsb pdb:4MEL|rcsb pdb:5OK6|reactome:R-HSA-390471|reactome:R-HSA-5689880|refseq:NP_004642.2|refseq:XP_011542290.1|refseq:XP_005272731.1|dip:DIP-27567N ensembl:ENSG00000165312(gene)|ensembl:ENST00000376495(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0070536"(protein K63-linked deubiquitination)|interpro:IPR003323(Ovarian tumour, otubain)|interpro:IPR038765|rcsb pdb:4BOP|refseq:NP_001138845.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2021/11/30 rogid:OSJLLFBf1ofw8SC01p2iiIM1oJo9606 rogid:BISOnPKUXNIZ+cNVrtvnKJpw3sA9606 intact-crc:F03843AD8CE15831|rigid:IMJbqoiSzxb7cKQYWRYWV8k10c0 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P51784 uniprotkb:Q4VCS5 intact:EBI-306876|intact:EBI-1058416|uniprotkb:Q8IUG6|uniprotkb:Q9BWE1|uniprotkb:B2RTX1|ensembl:ENSP00000218348 intact:EBI-2511319|ensembl:ENSP00000361027|uniprotkb:Q504X5|uniprotkb:Q9UPT1|uniprotkb:Q9HD27 psi-mi:ubp11_human(display_long)|uniprotkb:USP11(gene name)|psi-mi:USP11(display_short)|uniprotkb:UHX1(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 11(gene name synonym)|uniprotkb:Deubiquitinating enzyme 11(gene name synonym)|uniprotkb:Ubiquitin thioesterase 11(gene name synonym) psi-mi:amot_human(display_long)|uniprotkb:AMOT(gene name)|psi-mi:AMOT(display_short)|uniprotkb:KIAA1071(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511298|imex:IM-12079-66 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000102226(gene)|ensembl:ENST00000218348(transcript)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR018200|interpro:IPR028135|interpro:IPR028889|interpro:IPR029346|interpro:IPR035927|interpro:IPR038765|mint:P51784|rcsb pdb:4MEL|rcsb pdb:5OK6|reactome:R-HSA-390471|reactome:R-HSA-5689880|refseq:NP_004642.2|refseq:XP_011542290.1|refseq:XP_005272731.1|dip:DIP-27567N ensembl:ENSG00000126016(gene)|ensembl:ENST00000371959(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0001725"(stress fiber)|go:"GO:0001726"(ruffle)|go:"GO:0003365"(establishment of cell polarity involved in ameboidal cell migration)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006935"(chemotaxis)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030054"(cell junction)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035329"(hippo signaling)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0040019"(positive regulation of embryonic development)|go:"GO:0042074"(cell migration involved in gastrulation)|go:"GO:0043116"(negative regulation of vascular permeability)|go:"GO:0043532"(angiostatin binding)|go:"GO:0043534"(blood vessel endothelial cell migration)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0051496"(positive regulation of stress fiber assembly)|interpro:IPR009114(Angiomotin)|interpro:IPR024646|mint:Q4VCS5|rcsb pdb:6JJX|reactome:R-HSA-2028269|refseq:XP_011529177.1|refseq:NP_001106962.1|refseq:NP_573572.1|refseq:XP_005262144.1|refseq:XP_005262147.1|refseq:XP_016884778.1|dip:DIP-53711N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2021/11/30 rogid:OSJLLFBf1ofw8SC01p2iiIM1oJo9606 rogid:5O9K+GgX1s0Hn5optTeKPOs+X1s9606 intact-crc:F03843AD8CE15831|rigid:IMJbqoiSzxb7cKQYWRYWV8k10c0 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P51784 uniprotkb:Q96EI5 intact:EBI-306876|intact:EBI-1058416|uniprotkb:Q8IUG6|uniprotkb:Q9BWE1|uniprotkb:B2RTX1|ensembl:ENSP00000218348 intact:EBI-2511291|ensembl:ENSP00000415564|ensembl:ENSP00000421156|ensembl:ENSP00000424314|ensembl:ENSP00000427494|ensembl:ENSP00000421857|uniprotkb:Q9H2H1|uniprotkb:Q9H775|uniprotkb:Q8WY12 psi-mi:ubp11_human(display_long)|uniprotkb:USP11(gene name)|psi-mi:USP11(display_short)|uniprotkb:UHX1(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 11(gene name synonym)|uniprotkb:Deubiquitinating enzyme 11(gene name synonym)|uniprotkb:Ubiquitin thioesterase 11(gene name synonym) psi-mi:tcal4_human(display_long)|uniprotkb:TCEAL4(gene name)|psi-mi:TCEAL4(display_short)|uniprotkb:Transcription elongation factor S-II protein-like 4(gene name synonym)|uniprotkb:NPD017(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511298|imex:IM-12079-66 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000102226(gene)|ensembl:ENST00000218348(transcript)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR018200|interpro:IPR028135|interpro:IPR028889|interpro:IPR029346|interpro:IPR035927|interpro:IPR038765|mint:P51784|rcsb pdb:4MEL|rcsb pdb:5OK6|reactome:R-HSA-390471|reactome:R-HSA-5689880|refseq:NP_004642.2|refseq:XP_011542290.1|refseq:XP_005272731.1|dip:DIP-27567N ensembl:ENSG00000133142(gene)|ensembl:ENST00000415568(transcript)|ensembl:ENST00000468024(transcript)|ensembl:ENST00000472484(transcript)|ensembl:ENST00000472745(transcript)|ensembl:ENST00000494801(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0050699"(WW domain binding)|interpro:IPR021156|refseq:NP_001292769.1|refseq:NP_001292770.1|refseq:NP_001292771.1|refseq:NP_001006936.1|refseq:NP_001006938.1|refseq:NP_079139.4|refseq:NP_001287830.1|refseq:XP_016885346.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2021/11/30 rogid:OSJLLFBf1ofw8SC01p2iiIM1oJo9606 rogid:fR3mlHCl98Bd+Gy3XGTmmev/gRM9606 intact-crc:F03843AD8CE15831|rigid:IMJbqoiSzxb7cKQYWRYWV8k10c0 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P51784 uniprotkb:P78406 intact:EBI-306876|intact:EBI-1058416|uniprotkb:Q8IUG6|uniprotkb:Q9BWE1|uniprotkb:B2RTX1|ensembl:ENSP00000218348 intact:EBI-724495|uniprotkb:O15306|uniprotkb:Q3SYL7|uniprotkb:Q5TCH8|uniprotkb:Q6V708|uniprotkb:Q9H100|uniprotkb:Q9NQM6|ensembl:ENSP00000360286|ensembl:ENSP00000379181|ensembl:ENSP00000379182|uniprotkb:A8K882 psi-mi:ubp11_human(display_long)|uniprotkb:USP11(gene name)|psi-mi:USP11(display_short)|uniprotkb:UHX1(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 11(gene name synonym)|uniprotkb:Deubiquitinating enzyme 11(gene name synonym)|uniprotkb:Ubiquitin thioesterase 11(gene name synonym) psi-mi:rae1l_human(display_long)|uniprotkb:mRNA-associated protein mrnp 41(gene name synonym)|uniprotkb:Rae1 protein homolog(gene name synonym)|uniprotkb:RAE1(gene name)|psi-mi:RAE1(display_short)|uniprotkb:MRNP41(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511298|imex:IM-12079-66 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000102226(gene)|ensembl:ENST00000218348(transcript)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR018200|interpro:IPR028135|interpro:IPR028889|interpro:IPR029346|interpro:IPR035927|interpro:IPR038765|mint:P51784|rcsb pdb:4MEL|rcsb pdb:5OK6|reactome:R-HSA-390471|reactome:R-HSA-5689880|refseq:NP_004642.2|refseq:XP_011542290.1|refseq:XP_005272731.1|dip:DIP-27567N refseq:NP_001015885.1|refseq:NP_003601.1|ensembl:ENSG00000101146(gene)|ensembl:ENST00000371242(transcript)|ensembl:ENST00000395840(transcript)|ensembl:ENST00000395841(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006405"(RNA export from nucleus)|go:"GO:0006406"(mRNA export from nucleus)|go:"GO:0007049"(cell cycle)|go:"GO:0008017"(microtubule binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0051301"(cell division)|go:"GO:0060236"(regulation of mitotic spindle organization)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0097431"(mitotic spindle pole)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|go:"GO:0000972"(transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery)|interpro:IPR020472|interpro:IPR036322|interpro:IPR037631|mint:P78406|rcsb pdb:3MMY|rcsb pdb:4OWR|reactome:R-HSA-1169408|reactome:R-HSA-159227|reactome:R-HSA-159230|reactome:R-HSA-159231|reactome:R-HSA-159236|reactome:R-HSA-165054|reactome:R-HSA-168271|reactome:R-HSA-168276|reactome:R-HSA-168325|reactome:R-HSA-168333|reactome:R-HSA-170822|reactome:R-HSA-180746|reactome:R-HSA-180910|reactome:R-HSA-191859|reactome:R-HSA-3108214|reactome:R-HSA-3232142|reactome:R-HSA-3301854|reactome:R-HSA-3371453|reactome:R-HSA-4085377|reactome:R-HSA-4551638|reactome:R-HSA-4570464|interpro:IPR019775|reactome:R-HSA-4615885|reactome:R-HSA-5578749|reactome:R-HSA-5619107|reactome:R-HSA-6784531|reactome:R-HSA-9609690|reactome:R-HSA-9610379|refseq:XP_011527390.1|refseq:XP_011527391.1|refseq:XP_005260639.2|dip:DIP-41063N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2021/11/30 rogid:OSJLLFBf1ofw8SC01p2iiIM1oJo9606 rogid:JK4Y5p3WUcHFXBXyhhqCnDnG49c9606 intact-crc:F03843AD8CE15831|rigid:IMJbqoiSzxb7cKQYWRYWV8k10c0 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P51784 uniprotkb:Q9H9Y6 intact:EBI-306876|intact:EBI-1058416|uniprotkb:Q8IUG6|uniprotkb:Q9BWE1|uniprotkb:B2RTX1|ensembl:ENSP00000218348 intact:EBI-355441|uniprotkb:Q6ZRR2|uniprotkb:Q9H9D3|uniprotkb:Q585T5|uniprotkb:B7Z6Y7|uniprotkb:B7Z823|uniprotkb:F5GZX4|uniprotkb:F8W898|uniprotkb:Q2TAM4|ensembl:ENSP00000263331 psi-mi:ubp11_human(display_long)|uniprotkb:USP11(gene name)|psi-mi:USP11(display_short)|uniprotkb:UHX1(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 11(gene name synonym)|uniprotkb:Deubiquitinating enzyme 11(gene name synonym)|uniprotkb:Ubiquitin thioesterase 11(gene name synonym) psi-mi:rpa2_human(display_long)|uniprotkb:POLR1B(gene name)|psi-mi:POLR1B(display_short)|uniprotkb:DNA-directed RNA polymerase I 135 kDa polypeptide(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511298|imex:IM-12079-66 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000102226(gene)|ensembl:ENST00000218348(transcript)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR018200|interpro:IPR028135|interpro:IPR028889|interpro:IPR029346|interpro:IPR035927|interpro:IPR038765|mint:P51784|rcsb pdb:4MEL|rcsb pdb:5OK6|reactome:R-HSA-390471|reactome:R-HSA-5689880|refseq:NP_004642.2|refseq:XP_011542290.1|refseq:XP_005272731.1|dip:DIP-27567N refseq:NP_001131076.1|refseq:NP_061887.2|refseq:NP_001269703.1|refseq:NP_001269705.1|refseq:NP_001269706.1|refseq:NP_001269708.1|refseq:NP_001269701.1|dip:DIP-27538N|interpro:IPR007641(RNA polymerase Rpb2, domain 7)|interpro:IPR007642(RNA polymerase Rpb2, domain 2)|interpro:IPR007644(RNA polymerase, beta subunit, protrusion)|interpro:IPR007645(RNA polymerase Rpb2, domain 3)|interpro:IPR009674(RNA polymerase I, Rpa2 specific)|interpro:IPR014724(RNA polymerase Rpb2, OB-fold)|interpro:IPR015712(DNA-directed RNA polymerase, subunit 2)|interpro:IPR037033|interpro:IPR037034|mint:Q9H9Y6|reactome:R-HSA-427413|reactome:R-HSA-5250924|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73863|interpro:IPR007120(DNA-directed RNA polymerase, subunit 2, domain 6)|interpro:IPR007121(RNA polymerase, beta subunit, conserved site)|ensembl:ENSG00000125630(gene)|ensembl:ENST00000263331(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003899"(DNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005736"(RNA polymerase I complex)|go:"GO:0005829"(cytosol)|go:"GO:0007566"(embryo implantation)|go:"GO:0009303"(rRNA transcription)|go:"GO:0014029"(neural crest formation)|go:"GO:0017126"(nucleologenesis)|go:"GO:0032549"(ribonucleoside binding)|go:"GO:0046872"(metal ion binding) psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2021/11/30 rogid:OSJLLFBf1ofw8SC01p2iiIM1oJo9606 rogid:enAJckjxEU6bE3J3OA5pFREXC3U9606 intact-crc:F03843AD8CE15831|rigid:IMJbqoiSzxb7cKQYWRYWV8k10c0 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P51784 uniprotkb:O43684 intact:EBI-306876|intact:EBI-1058416|uniprotkb:Q8IUG6|uniprotkb:Q9BWE1|uniprotkb:B2RTX1|ensembl:ENSP00000218348 intact:EBI-1050987|uniprotkb:O43685|uniprotkb:B2R6E7|uniprotkb:A6NJ42|uniprotkb:D3DRE9|ensembl:ENSP00000357858 psi-mi:ubp11_human(display_long)|uniprotkb:USP11(gene name)|psi-mi:USP11(display_short)|uniprotkb:UHX1(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 11(gene name synonym)|uniprotkb:Deubiquitinating enzyme 11(gene name synonym)|uniprotkb:Ubiquitin thioesterase 11(gene name synonym) psi-mi:bub3_human(display_long)|uniprotkb:BUB3(gene name)|psi-mi:BUB3(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511298|imex:IM-12079-66 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000102226(gene)|ensembl:ENST00000218348(transcript)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR018200|interpro:IPR028135|interpro:IPR028889|interpro:IPR029346|interpro:IPR035927|interpro:IPR038765|mint:P51784|rcsb pdb:4MEL|rcsb pdb:5OK6|reactome:R-HSA-390471|reactome:R-HSA-5689880|refseq:NP_004642.2|refseq:XP_011542290.1|refseq:XP_005272731.1|dip:DIP-27567N refseq:NP_001007794.1|refseq:NP_004716.1|ensembl:ENSG00000154473(gene)|ensembl:ENST00000368865(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000776"(kinetochore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|interpro:IPR020472|interpro:IPR036322|mint:O43684|reactome:R-HSA-141430|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|reactome:R-HSA-141444|reactome:R-HSA-174184|reactome:R-HSA-176409|reactome:R-HSA-179409|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|go:"GO:0008608"(attachment of spindle microtubules to kinetochore)|reactome:R-HSA-68877|reactome:R-HSA-9648025|go:"GO:0033597"(mitotic checkpoint complex)|go:"GO:0034501"(protein localization to kinetochore)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0051301"(cell division)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:1990298"(bub1-bub3 complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|dip:DIP-24205N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2021/11/30 rogid:OSJLLFBf1ofw8SC01p2iiIM1oJo9606 rogid:nqzARPql2cThSUpxSb6PuTRn51E9606 intact-crc:F03843AD8CE15831|rigid:IMJbqoiSzxb7cKQYWRYWV8k10c0 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P51784 uniprotkb:P17028 intact:EBI-306876|intact:EBI-1058416|uniprotkb:Q8IUG6|uniprotkb:Q9BWE1|uniprotkb:B2RTX1|ensembl:ENSP00000218348 intact:EBI-707773|uniprotkb:O14754|uniprotkb:Q53YE4|uniprotkb:Q6ICR5|uniprotkb:Q8IZN4|ensembl:ENSP00000261332|ensembl:ENSP00000382015 psi-mi:ubp11_human(display_long)|uniprotkb:USP11(gene name)|psi-mi:USP11(display_short)|uniprotkb:UHX1(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 11(gene name synonym)|uniprotkb:Deubiquitinating enzyme 11(gene name synonym)|uniprotkb:Ubiquitin thioesterase 11(gene name synonym) psi-mi:znf24_human(display_long)|uniprotkb:Zinc finger protein 191(gene name synonym)|uniprotkb:Zinc finger protein KOX17(gene name synonym)|uniprotkb:Retinoic acid suppression protein A(gene name synonym)|uniprotkb:Zinc finger and SCAN domain-containing protein 3(gene name synonym)|uniprotkb:ZNF24(gene name)|psi-mi:ZNF24(display_short)|uniprotkb:KOX17(gene name synonym)|uniprotkb:ZNF191(gene name synonym)|uniprotkb:ZSCAN3(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511298|imex:IM-12079-66 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000102226(gene)|ensembl:ENST00000218348(transcript)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR018200|interpro:IPR028135|interpro:IPR028889|interpro:IPR029346|interpro:IPR035927|interpro:IPR038765|mint:P51784|rcsb pdb:4MEL|rcsb pdb:5OK6|reactome:R-HSA-390471|reactome:R-HSA-5689880|refseq:NP_004642.2|refseq:XP_011542290.1|refseq:XP_005272731.1|dip:DIP-27567N refseq:NP_008896.2|refseq:XP_005258398.1|refseq:NP_001295052.1|ensembl:ENSG00000172466(gene)|ensembl:ENST00000261332(transcript)|ensembl:ENST00000399061(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0042552"(myelination)|go:"GO:0042802"(identical protein binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|interpro:IPR003309(Transcriptional regulator SCAN)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|interpro:IPR038269|mint:P17028|rcsb pdb:1X6E|rcsb pdb:3LHR psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2021/11/30 rogid:OSJLLFBf1ofw8SC01p2iiIM1oJo9606 rogid:JkUMu2FtBQTBFKK1fj5wxMA1bjQ9606 intact-crc:F03843AD8CE15831|rigid:IMJbqoiSzxb7cKQYWRYWV8k10c0 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P51784 uniprotkb:Q5T9A4 intact:EBI-306876|intact:EBI-1058416|uniprotkb:Q8IUG6|uniprotkb:Q9BWE1|uniprotkb:B2RTX1|ensembl:ENSP00000218348 intact:EBI-1384144|uniprotkb:Q6ZRB5|uniprotkb:Q9BUK4|uniprotkb:Q9ULE7|uniprotkb:A8K3H1|ensembl:ENSP00000500094 psi-mi:ubp11_human(display_long)|uniprotkb:USP11(gene name)|psi-mi:USP11(display_short)|uniprotkb:UHX1(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 11(gene name synonym)|uniprotkb:Deubiquitinating enzyme 11(gene name synonym)|uniprotkb:Ubiquitin thioesterase 11(gene name synonym) psi-mi:atd3b_human(display_long)|uniprotkb:TOB3(gene name synonym)|uniprotkb:AAA-TOB3(gene name synonym)|uniprotkb:KIAA1273(gene name synonym)|uniprotkb:ATAD3B(gene name)|psi-mi:ATAD3B(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511298|imex:IM-12079-66 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000102226(gene)|ensembl:ENST00000218348(transcript)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR018200|interpro:IPR028135|interpro:IPR028889|interpro:IPR029346|interpro:IPR035927|interpro:IPR038765|mint:P51784|rcsb pdb:4MEL|rcsb pdb:5OK6|reactome:R-HSA-390471|reactome:R-HSA-5689880|refseq:NP_004642.2|refseq:XP_011542290.1|refseq:XP_005272731.1|dip:DIP-27567N refseq:NP_114127.3|refseq:NP_001304167.1|ensembl:ENSG00000160072(gene)|ensembl:ENST00000673477(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0101003"(ficolin-1-rich granule membrane)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR021911|interpro:IPR027417|interpro:IPR039188|mint:Q5T9A4|reactome:R-HSA-6798695 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2021/11/30 rogid:OSJLLFBf1ofw8SC01p2iiIM1oJo9606 rogid:2W52iPQhTBU2apShm8xhfenV1mU9606 intact-crc:F03843AD8CE15831|rigid:IMJbqoiSzxb7cKQYWRYWV8k10c0 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P51784 uniprotkb:P49790 intact:EBI-306876|intact:EBI-1058416|uniprotkb:Q8IUG6|uniprotkb:Q9BWE1|uniprotkb:B2RTX1|ensembl:ENSP00000218348 intact:EBI-286779|uniprotkb:Q5T9I7|intact:EBI-1237421|uniprotkb:E7EPX5|uniprotkb:Q4LE47|uniprotkb:Q7Z743|uniprotkb:B4DIK2|uniprotkb:F6QR24|ensembl:ENSP00000262077 psi-mi:ubp11_human(display_long)|uniprotkb:USP11(gene name)|psi-mi:USP11(display_short)|uniprotkb:UHX1(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 11(gene name synonym)|uniprotkb:Deubiquitinating enzyme 11(gene name synonym)|uniprotkb:Ubiquitin thioesterase 11(gene name synonym) psi-mi:nu153_human(display_long)|uniprotkb:Nucleoporin Nup153(gene name synonym)|uniprotkb:153 kDa nucleoporin(gene name synonym)|uniprotkb:NUP153(gene name)|psi-mi:NUP153(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511298|imex:IM-12079-66 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000102226(gene)|ensembl:ENST00000218348(transcript)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR018200|interpro:IPR028135|interpro:IPR028889|interpro:IPR029346|interpro:IPR035927|interpro:IPR038765|mint:P51784|rcsb pdb:4MEL|rcsb pdb:5OK6|reactome:R-HSA-390471|reactome:R-HSA-5689880|refseq:NP_004642.2|refseq:XP_011542290.1|refseq:XP_005272731.1|dip:DIP-27567N ensembl:ENSP00000262077|ensembl:ENST00000537253|ensembl:ENSP00000444029|ensembl:ENST00000613258|ensembl:ENSP00000478627|refseq:NP_005115.2|refseq:NP_001265138.1|refseq:NP_001265139.1|dip:DIP-38185N|ensembl:ENSG00000124789(gene)|ensembl:ENST00000262077(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006405"(RNA export from nucleus)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0016020"(membrane)|go:"GO:0017056"(structural constituent of nuclear pore)|go:"GO:0031965"(nuclear membrane)|go:"GO:0034399"(nuclear periphery)|go:"GO:0042405"(nuclear inclusion body)|go:"GO:0042802"(identical protein binding)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0043657"(host cell)|go:"GO:0044615"(nuclear pore nuclear basket)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046832"(negative regulation of RNA export from nucleus)|go:"GO:0046872"(metal ion binding)|go:"GO:0051028"(mRNA transport)|go:"GO:0051292"(nuclear pore complex assembly)|go:"GO:0075732"(viral penetration into host nucleus)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR013913(Nucleoporin, Nup153-like)|interpro:IPR018892|interpro:IPR026054|interpro:IPR036443|mint:P49790|rcsb pdb:2EBQ|rcsb pdb:2EBR|rcsb pdb:2EBV|rcsb pdb:2GQE|rcsb pdb:4U0C|rcsb pdb:4U0D|rcsb pdb:5TSV|rcsb pdb:5TSX|rcsb pdb:6AYA|reactome:R-HSA-1169408|reactome:R-HSA-159227|reactome:R-HSA-159230|reactome:R-HSA-159231|reactome:R-HSA-159236|reactome:R-HSA-165054|reactome:R-HSA-168271|reactome:R-HSA-168276|reactome:R-HSA-168325|reactome:R-HSA-168333|reactome:R-HSA-170822|reactome:R-HSA-180746|reactome:R-HSA-180910|reactome:R-HSA-191859|reactome:R-HSA-3108214|reactome:R-HSA-3232142|reactome:R-HSA-3301854|reactome:R-HSA-3371453|reactome:R-HSA-4085377|reactome:R-HSA-4551638|reactome:R-HSA-4570464|reactome:R-HSA-4615885|reactome:R-HSA-5578749|reactome:R-HSA-5619107|reactome:R-HSA-6784531|reactome:R-HSA-9609690|reactome:R-HSA-9610379 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2021/11/30 rogid:OSJLLFBf1ofw8SC01p2iiIM1oJo9606 rogid:rOax/ikcAu5fmDiCOauVr7Y/fzY9606 intact-crc:F03843AD8CE15831|rigid:IMJbqoiSzxb7cKQYWRYWV8k10c0 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P51784 uniprotkb:Q9Y6Y0 intact:EBI-306876|intact:EBI-1058416|uniprotkb:Q8IUG6|uniprotkb:Q9BWE1|uniprotkb:B2RTX1|ensembl:ENSP00000218348 intact:EBI-715774|uniprotkb:Q1G4T6|uniprotkb:Q1G4T7|uniprotkb:Q5TF75|uniprotkb:Q6NW38|uniprotkb:Q7LCG2|uniprotkb:Q9NZX0|uniprotkb:Q9Y480|uniprotkb:A8K8R6|ensembl:ENSP00000356468 psi-mi:ubp11_human(display_long)|uniprotkb:USP11(gene name)|psi-mi:USP11(display_short)|uniprotkb:UHX1(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 11(gene name synonym)|uniprotkb:Deubiquitinating enzyme 11(gene name synonym)|uniprotkb:Ubiquitin thioesterase 11(gene name synonym) psi-mi:ns1bp_human(display_long)|uniprotkb:Aryl hydrocarbon receptor-associated protein 3(gene name synonym)|uniprotkb:IVNS1ABP(gene name)|psi-mi:IVNS1ABP(display_short)|uniprotkb:ARA3(gene name synonym)|uniprotkb:FLARA3(gene name synonym)|uniprotkb:KIAA0850(gene name synonym)|uniprotkb:NS1(gene name synonym)|uniprotkb:NS1BP(gene name synonym)|uniprotkb:HSPC068(orf name)|uniprotkb:KLHL39(gene name synonym)|uniprotkb:Kelch-like protein 39(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511298|imex:IM-12079-66 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000102226(gene)|ensembl:ENST00000218348(transcript)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR018200|interpro:IPR028135|interpro:IPR028889|interpro:IPR029346|interpro:IPR035927|interpro:IPR038765|mint:P51784|rcsb pdb:4MEL|rcsb pdb:5OK6|reactome:R-HSA-390471|reactome:R-HSA-5689880|refseq:NP_004642.2|refseq:XP_011542290.1|refseq:XP_005272731.1|dip:DIP-27567N refseq:NP_006460.2|ensembl:ENSG00000116679(gene)|ensembl:ENST00000367498(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006383"(transcription by RNA polymerase III)|go:"GO:0008380"(RNA splicing)|go:"GO:0009615"(response to virus)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR011705(BTB/Kelch-associated)|interpro:IPR017096(Kelch-like protein, gigaxonin)|rcsb pdb:5YY8|rcsb pdb:6N34|rcsb pdb:6N3H|interpro:IPR015915(Kelch-type beta propeller) psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2021/11/30 rogid:OSJLLFBf1ofw8SC01p2iiIM1oJo9606 rogid:27jzoex7cmDEgCPCpPMGbZ0pj489606 intact-crc:F03843AD8CE15831|rigid:IMJbqoiSzxb7cKQYWRYWV8k10c0 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P51784 uniprotkb:O15160 intact:EBI-306876|intact:EBI-1058416|uniprotkb:Q8IUG6|uniprotkb:Q9BWE1|uniprotkb:B2RTX1|ensembl:ENSP00000218348 intact:EBI-1055079|uniprotkb:O75395|uniprotkb:Q5JTE3|ensembl:ENSP00000496044 psi-mi:ubp11_human(display_long)|uniprotkb:USP11(gene name)|psi-mi:USP11(display_short)|uniprotkb:UHX1(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 11(gene name synonym)|uniprotkb:Deubiquitinating enzyme 11(gene name synonym)|uniprotkb:Ubiquitin thioesterase 11(gene name synonym) psi-mi:rpac1_human(display_long)|uniprotkb:DNA-directed RNA polymerases I and III 40 kDa polypeptide(gene name synonym)|uniprotkb:RPC40(gene name synonym)|uniprotkb:AC40(gene name synonym)|uniprotkb:RPA39(gene name synonym)|uniprotkb:POLR1C(gene name)|psi-mi:POLR1C(display_short)|uniprotkb:POLR1E(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511298|imex:IM-12079-66 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000102226(gene)|ensembl:ENST00000218348(transcript)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR018200|interpro:IPR028135|interpro:IPR028889|interpro:IPR029346|interpro:IPR035927|interpro:IPR038765|mint:P51784|rcsb pdb:4MEL|rcsb pdb:5OK6|reactome:R-HSA-390471|reactome:R-HSA-5689880|refseq:NP_004642.2|refseq:XP_011542290.1|refseq:XP_005272731.1|dip:DIP-27567N refseq:NP_001305805.1|refseq:NP_976035.1|ensembl:ENSG00000171453(gene)|ensembl:ENST00000642195(transcript)|go:"GO:0001054"(RNA polymerase I activity)|go:"GO:0001056"(RNA polymerase III activity)|go:"GO:0003677"(DNA binding)|go:"GO:0003899"(DNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005666"(RNA polymerase III complex)|go:"GO:0005736"(RNA polymerase I complex)|go:"GO:0005829"(cytosol)|go:"GO:0006360"(transcription by RNA polymerase I)|go:"GO:0046983"(protein dimerization activity)|interpro:IPR001514(DNA-directed RNA polymerase, 30-40 kDa subunit, conserved site)|interpro:IPR011262(DNA-directed RNA polymerase, insert)|interpro:IPR011263(DNA-directed RNA polymerase, RpoA/D/Rpb3-type)|interpro:IPR033901|interpro:IPR036603|interpro:IPR036643|mint:O15160|rcsb pdb:7A6H|rcsb pdb:7AE1|rcsb pdb:7AE3|rcsb pdb:7AEA|rcsb pdb:7AST|rcsb pdb:7D58|rcsb pdb:7D59|rcsb pdb:7DN3|rcsb pdb:7DU2|reactome:R-HSA-1834949|reactome:R-HSA-427413|reactome:R-HSA-5250924|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73780|reactome:R-HSA-73863|reactome:R-HSA-73980|reactome:R-HSA-749476|reactome:R-HSA-76061|reactome:R-HSA-76066|reactome:R-HSA-76071|dip:DIP-27587N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2021/11/30 rogid:OSJLLFBf1ofw8SC01p2iiIM1oJo9606 rogid:xSIuJ9kjLRZ6Vc9EnLdvX/CBJKU9606 intact-crc:F03843AD8CE15831|rigid:IMJbqoiSzxb7cKQYWRYWV8k10c0 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P51784 uniprotkb:P98170 intact:EBI-306876|intact:EBI-1058416|uniprotkb:Q8IUG6|uniprotkb:Q9BWE1|uniprotkb:B2RTX1|ensembl:ENSP00000218348 intact:EBI-517127|uniprotkb:Q9NQ14|uniprotkb:D3DTF2|ensembl:ENSP00000347858|ensembl:ENSP00000360242|ensembl:ENSP00000395230 psi-mi:ubp11_human(display_long)|uniprotkb:USP11(gene name)|psi-mi:USP11(display_short)|uniprotkb:UHX1(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 11(gene name synonym)|uniprotkb:Deubiquitinating enzyme 11(gene name synonym)|uniprotkb:Ubiquitin thioesterase 11(gene name synonym) psi-mi:xiap_human(display_long)|uniprotkb:Inhibitor of apoptosis protein 3(gene name synonym)|uniprotkb:X-linked inhibitor of apoptosis protein(gene name synonym)|uniprotkb:IAP-like protein(gene name synonym)|uniprotkb:XIAP(gene name)|psi-mi:XIAP(display_short)|uniprotkb:API3(gene name synonym)|uniprotkb:IAP3(gene name synonym)|uniprotkb:BIRC4(gene name synonym)|uniprotkb:Baculoviral IAP repeat-containing protein 4(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase XIAP(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511298|imex:IM-12079-66 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000102226(gene)|ensembl:ENST00000218348(transcript)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR018200|interpro:IPR028135|interpro:IPR028889|interpro:IPR029346|interpro:IPR035927|interpro:IPR038765|mint:P51784|rcsb pdb:4MEL|rcsb pdb:5OK6|reactome:R-HSA-390471|reactome:R-HSA-5689880|refseq:NP_004642.2|refseq:XP_011542290.1|refseq:XP_005272731.1|dip:DIP-27567N refseq:XP_006724817.1|refseq:NP_001158.2|refseq:NP_001191330.1|refseq:XP_011529631.1|dip:DIP-27626N|ensembl:ENSG00000101966(gene)|ensembl:ENST00000355640(transcript)|ensembl:ENST00000371199(transcript)|ensembl:ENST00000434753(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005876"(spindle microtubule)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030510"(regulation of BMP signaling pathway)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0055070"(copper ion homeostasis)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070424"(regulation of nucleotide-binding oligomerization domain containing signaling pathway)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1902530"(positive regulation of protein linear polyubiquitination)|go:"GO:1990001"(inhibition of cysteine-type endopeptidase activity involved in apoptotic process)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011029(DEATH-like)|interpro:IPR042579|mint:P98170|rcsb pdb:1C9Q|rcsb pdb:1F9X|rcsb pdb:1G3F|rcsb pdb:1G73|rcsb pdb:1I3O|rcsb pdb:1I4O|rcsb pdb:1I51|rcsb pdb:1KMC|rcsb pdb:1NW9|rcsb pdb:1TFQ|rcsb pdb:1TFT|rcsb pdb:2ECG|rcsb pdb:2JK7|rcsb pdb:2KNA|rcsb pdb:2OPY|rcsb pdb:2OPZ|rcsb pdb:2POI|rcsb pdb:2POP|rcsb pdb:2QRA|rcsb pdb:2VSL|rcsb pdb:3CLX|rcsb pdb:3CM2|rcsb pdb:3CM7|rcsb pdb:3EYL|rcsb pdb:3G76|rcsb pdb:3HL5|rcsb pdb:3UW4|rcsb pdb:3UW5|rcsb pdb:4EC4|rcsb pdb:4HY0|rcsb pdb:4IC2|rcsb pdb:4IC3|rcsb pdb:4J3Y|rcsb pdb:4J44|rcsb pdb:4J45|rcsb pdb:4J46|rcsb pdb:4J47|rcsb pdb:4J48|rcsb pdb:4KJU|rcsb pdb:4KJV|rcsb pdb:4KMP|rcsb pdb:4MTZ|rcsb pdb:4OXC|rcsb pdb:4WVS|rcsb pdb:4WVT|rcsb pdb:4WVU|rcsb pdb:5C0K|rcsb pdb:5C0L|rcsb pdb:5C3H|rcsb pdb:5C3K|rcsb pdb:5C7A|rcsb pdb:5C7B|rcsb pdb:5C7C|rcsb pdb:5C7D|rcsb pdb:5C83|rcsb pdb:5C84|rcsb pdb:5M6E|rcsb pdb:5M6F|rcsb pdb:5M6H|rcsb pdb:5M6L|rcsb pdb:5M6M|rcsb pdb:5O6T|rcsb pdb:5OQW|rcsb pdb:6EY2|rcsb pdb:6GJW|rcsb pdb:6QCI|reactome:R-HSA-111459|reactome:R-HSA-111463|reactome:R-HSA-111464|reactome:R-HSA-111469|reactome:R-HSA-3769402|reactome:R-HSA-5213460|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5675482|reactome:R-HSA-8948747|reactome:R-HSA-8948751|reactome:R-HSA-9627069 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2021/11/30 rogid:OSJLLFBf1ofw8SC01p2iiIM1oJo9606 rogid:6eDcOay+c2ZmIAD/pwnCDROBwgM9606 intact-crc:F03843AD8CE15831|rigid:IMJbqoiSzxb7cKQYWRYWV8k10c0 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P51784 uniprotkb:Q9NYZ3 intact:EBI-306876|intact:EBI-1058416|uniprotkb:Q8IUG6|uniprotkb:Q9BWE1|uniprotkb:B2RTX1|ensembl:ENSP00000218348 intact:EBI-2511327|intact:EBI-28974182|ensembl:ENSP00000415430|uniprotkb:Q9BRE0|uniprotkb:Q53GX5|uniprotkb:Q20WK2|uniprotkb:Q9UGZ9|uniprotkb:Q6DHX4|uniprotkb:Q5R3I6|uniprotkb:Q9Y557|uniprotkb:B0QYM3 psi-mi:ubp11_human(display_long)|uniprotkb:USP11(gene name)|psi-mi:USP11(display_short)|uniprotkb:UHX1(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 11(gene name synonym)|uniprotkb:Deubiquitinating enzyme 11(gene name synonym)|uniprotkb:Ubiquitin thioesterase 11(gene name synonym) psi-mi:gtse1_human(display_long)|uniprotkb:GTSE1(gene name)|psi-mi:GTSE1(display_short)|uniprotkb:Protein B99 homolog(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511298|imex:IM-12079-66 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000102226(gene)|ensembl:ENST00000218348(transcript)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR018200|interpro:IPR028135|interpro:IPR028889|interpro:IPR029346|interpro:IPR035927|interpro:IPR038765|mint:P51784|rcsb pdb:4MEL|rcsb pdb:5OK6|reactome:R-HSA-390471|reactome:R-HSA-5689880|refseq:NP_004642.2|refseq:XP_011542290.1|refseq:XP_005272731.1|dip:DIP-27567N ensembl:ENSG00000075218(gene)|ensembl:ENST00000454366(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0006977"(DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)|go:"GO:0007017"(microtubule-based process)|go:"GO:0008017"(microtubule binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|interpro:IPR026657|interpro:IPR026659|interpro:IPR032768|rcsb pdb:6QNN|rcsb pdb:6QNP|reactome:R-HSA-69481|reactome:R-HSA-8852276|ensembl:ENSP00000415430|refseq:NP_057510.4 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2021/11/30 rogid:OSJLLFBf1ofw8SC01p2iiIM1oJo9606 rogid:3vSRRbx11yGNbuaniX7ZtqE/cLI9606 intact-crc:F03843AD8CE15831|rigid:IMJbqoiSzxb7cKQYWRYWV8k10c0 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P51784 uniprotkb:Q16513 intact:EBI-306876|intact:EBI-1058416|uniprotkb:Q8IUG6|uniprotkb:Q9BWE1|uniprotkb:B2RTX1|ensembl:ENSP00000218348 intact:EBI-2511350|uniprotkb:Q9H1W4|uniprotkb:D3DT24|uniprotkb:B4DQ21|uniprotkb:B4DTP5|uniprotkb:B4DVG1|uniprotkb:Q08AF4|ensembl:ENSP00000359552 psi-mi:ubp11_human(display_long)|uniprotkb:USP11(gene name)|psi-mi:USP11(display_short)|uniprotkb:UHX1(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 11(gene name synonym)|uniprotkb:Deubiquitinating enzyme 11(gene name synonym)|uniprotkb:Ubiquitin thioesterase 11(gene name synonym) psi-mi:pkn2_human(display_long)|uniprotkb:PKN2(gene name)|psi-mi:PKN2(display_short)|uniprotkb:PRK2(gene name synonym)|uniprotkb:PRKCL2(gene name synonym)|uniprotkb:Protein kinase C-like 2(gene name synonym)|uniprotkb:Protein-kinase C-related kinase 2(gene name synonym)|uniprotkb:PKN gamma(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511298|imex:IM-12079-66 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000102226(gene)|ensembl:ENST00000218348(transcript)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR018200|interpro:IPR028135|interpro:IPR028889|interpro:IPR029346|interpro:IPR035927|interpro:IPR038765|mint:P51784|rcsb pdb:4MEL|rcsb pdb:5OK6|reactome:R-HSA-390471|reactome:R-HSA-5689880|refseq:NP_004642.2|refseq:XP_011542290.1|refseq:XP_005272731.1|dip:DIP-27567N refseq:XP_011540074.1|refseq:NP_006247.1|refseq:NP_001307636.1|refseq:NP_001307637.1|refseq:NP_001307638.1|ensembl:ENSG00000065243(gene)|ensembl:ENST00000370521(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0010631"(epithelial cell migration)|go:"GO:0016301"(kinase activity)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030496"(midbody)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032154"(cleavage furrow)|go:"GO:0005654"(nucleoplasm)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043296"(apical junction complex)|go:"GO:0043297"(apical junction assembly)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045296"(cadherin binding)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051301"(cell division)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000145"(regulation of cell motility)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011072(HR1 rho-binding repeat)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR035892|interpro:IPR036274|interpro:IPR037313|interpro:IPR037784|mint:Q16513|rcsb pdb:4CRS|rcsb pdb:4RRV|rcsb pdb:6CCY|rcsb pdb:6GBE|reactome:R-HSA-5625740|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013149|go:"GO:0032467"(positive regulation of cytokinesis) psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2021/11/30 rogid:OSJLLFBf1ofw8SC01p2iiIM1oJo9606 rogid:KvHDOJ75CgHIGDC+41jGKORm2+w9606 intact-crc:F03843AD8CE15831|rigid:IMJbqoiSzxb7cKQYWRYWV8k10c0 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P51784 uniprotkb:P19388 intact:EBI-306876|intact:EBI-1058416|uniprotkb:Q8IUG6|uniprotkb:Q9BWE1|uniprotkb:B2RTX1|ensembl:ENSP00000218348 intact:EBI-395189|uniprotkb:O43380|uniprotkb:Q6PIH5|uniprotkb:Q9BT06|uniprotkb:B2R6L4|uniprotkb:D6W5Y1|ensembl:ENSP00000464739|ensembl:ENSP00000478303|ensembl:ENSP00000485021 psi-mi:ubp11_human(display_long)|uniprotkb:USP11(gene name)|psi-mi:USP11(display_short)|uniprotkb:UHX1(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 11(gene name synonym)|uniprotkb:Deubiquitinating enzyme 11(gene name synonym)|uniprotkb:Ubiquitin thioesterase 11(gene name synonym) psi-mi:rpab1_human(display_long)|uniprotkb:POLR2E(gene name)|psi-mi:POLR2E(display_short)|uniprotkb:DNA-directed RNA polymerase II subunit E(gene name synonym)|uniprotkb:RPB5 homolog(gene name synonym)|uniprotkb:DNA-directed RNA polymerase II 23 kDa polypeptide(gene name synonym)|uniprotkb:XAP4(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511298|imex:IM-12079-66 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000102226(gene)|ensembl:ENST00000218348(transcript)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR018200|interpro:IPR028135|interpro:IPR028889|interpro:IPR029346|interpro:IPR035927|interpro:IPR038765|mint:P51784|rcsb pdb:4MEL|rcsb pdb:5OK6|reactome:R-HSA-390471|reactome:R-HSA-5689880|refseq:NP_004642.2|refseq:XP_011542290.1|refseq:XP_005272731.1|dip:DIP-27567N refseq:NP_002686.2|ensembl:ENSG00000099817(gene)|ensembl:ENST00000586746(transcript)|ensembl:ENST00000612655(transcript)|ensembl:ENST00000615234(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003899"(DNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005665"(RNA polymerase II, core complex)|go:"GO:0005666"(RNA polymerase III complex)|go:"GO:0005736"(RNA polymerase I complex)|go:"GO:0005829"(cytosol)|go:"GO:0006366"(transcription by RNA polymerase II)|interpro:IPR000783(RNA polymerase, subunit H/Rpb5 C-terminal)|interpro:IPR005571(RNA polymerase, Rpb5, N-terminal)|interpro:IPR014381(DNA-directed RNA polymerase, RPB5 subunit)|interpro:IPR020608|interpro:IPR020609|interpro:IPR035913|interpro:IPR036710|interpro:IPR039531|rcsb pdb:5IY8|rcsb pdb:5IY9|rcsb pdb:5IYA|rcsb pdb:5IYB|rcsb pdb:5IYC|rcsb pdb:5IYD|rcsb pdb:6DRD|rcsb pdb:6O9L|rcsb pdb:6XRE|rcsb pdb:7A6H|rcsb pdb:7AE1|rcsb pdb:7AE3|rcsb pdb:7AEA|rcsb pdb:7AST|rcsb pdb:7D58|rcsb pdb:7D59|rcsb pdb:7DN3|rcsb pdb:7DU2|rcsb pdb:7LBM|reactome:R-HSA-112382|reactome:R-HSA-113418|mint:P19388|rcsb pdb:5IY6|rcsb pdb:5IY7|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167160|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167242|reactome:R-HSA-167243|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-168325|reactome:R-HSA-1834949|reactome:R-HSA-203927|reactome:R-HSA-427413|reactome:R-HSA-5250924|reactome:R-HSA-5578749|reactome:R-HSA-5601884|reactome:R-HSA-5617472|reactome:R-HSA-674695|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6796648|reactome:R-HSA-6803529|reactome:R-HSA-6807505|reactome:R-HSA-72086|reactome:R-HSA-72163|reactome:R-HSA-72165|reactome:R-HSA-72203|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-73780|reactome:R-HSA-73863|reactome:R-HSA-73980|reactome:R-HSA-749476|reactome:R-HSA-75953|reactome:R-HSA-75955|reactome:R-HSA-76042|reactome:R-HSA-76061|reactome:R-HSA-76066|reactome:R-HSA-76071|reactome:R-HSA-77075|reactome:R-HSA-8851708|reactome:R-HSA-9018519|reactome:R-HSA-9670095|reactome:R-HSA-167246|dip:DIP-56N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2021/11/30 rogid:OSJLLFBf1ofw8SC01p2iiIM1oJo9606 rogid:BIVesx7KODhdpcgjhU6CghhXNQE9606 intact-crc:F03843AD8CE15831|rigid:IMJbqoiSzxb7cKQYWRYWV8k10c0 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P51784 uniprotkb:A0A804HIM8 intact:EBI-306876|intact:EBI-1058416|uniprotkb:Q8IUG6|uniprotkb:Q9BWE1|uniprotkb:B2RTX1|ensembl:ENSP00000218348 intact:EBI-2510474|ensembl:ENSP00000507145 psi-mi:ubp11_human(display_long)|uniprotkb:USP11(gene name)|psi-mi:USP11(display_short)|uniprotkb:UHX1(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 11(gene name synonym)|uniprotkb:Deubiquitinating enzyme 11(gene name synonym)|uniprotkb:Ubiquitin thioesterase 11(gene name synonym) psi-mi:a0a804him8_human(display_long)|uniprotkb:PRRC2B(gene name)|psi-mi:PRRC2B(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511298|imex:IM-12079-66 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000102226(gene)|ensembl:ENST00000218348(transcript)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR018200|interpro:IPR028135|interpro:IPR028889|interpro:IPR029346|interpro:IPR035927|interpro:IPR038765|mint:P51784|rcsb pdb:4MEL|rcsb pdb:5OK6|reactome:R-HSA-390471|reactome:R-HSA-5689880|refseq:NP_004642.2|refseq:XP_011542290.1|refseq:XP_005272731.1|dip:DIP-27567N ensembl:ENSG00000288701(gene)|ensembl:ENST00000684736(transcript)|uniprotkb:Q5JT00(uniprot-removed-ac) psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2021/11/30 rogid:OSJLLFBf1ofw8SC01p2iiIM1oJo9606 rogid:gWPDAy2o/Vkzm6l9Zj73tFnUxcs9606 intact-crc:F03843AD8CE15831|rigid:IMJbqoiSzxb7cKQYWRYWV8k10c0 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P51784 uniprotkb:Q96SU4 intact:EBI-306876|intact:EBI-1058416|uniprotkb:Q8IUG6|uniprotkb:Q9BWE1|uniprotkb:B2RTX1|ensembl:ENSP00000218348 intact:EBI-2511368|ensembl:ENSP00000407168|uniprotkb:Q6IA67|uniprotkb:Q9H9X2|uniprotkb:Q96SK4|uniprotkb:B1AKJ8|uniprotkb:Q5TFC0|uniprotkb:Q8NB17|uniprotkb:Q8TAS8|uniprotkb:D3DQ31|uniprotkb:B3KPQ4|uniprotkb:Q86YQ3 psi-mi:ubp11_human(display_long)|uniprotkb:USP11(gene name)|psi-mi:USP11(display_short)|uniprotkb:UHX1(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 11(gene name synonym)|uniprotkb:Deubiquitinating enzyme 11(gene name synonym)|uniprotkb:Ubiquitin thioesterase 11(gene name synonym) psi-mi:osbl9_human(display_long)|uniprotkb:OSBPL9(gene name)|psi-mi:OSBPL9(display_short)|uniprotkb:ORP9(gene name synonym)|uniprotkb:OSBP4(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511298|imex:IM-12079-66 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000102226(gene)|ensembl:ENST00000218348(transcript)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR018200|interpro:IPR028135|interpro:IPR028889|interpro:IPR029346|interpro:IPR035927|interpro:IPR038765|mint:P51784|rcsb pdb:4MEL|rcsb pdb:5OK6|reactome:R-HSA-390471|reactome:R-HSA-5689880|refseq:NP_004642.2|refseq:XP_011542290.1|refseq:XP_005272731.1|dip:DIP-27567N ensembl:ENSG00000117859(gene)|ensembl:ENST00000428468(transcript)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006699"(bile acid biosynthetic process)|go:"GO:0015248"(sterol transporter activity)|go:"GO:0016020"(membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032934"(sterol binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR000648(Oxysterol-binding protein)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR018494|interpro:IPR037239|mint:Q96SU4|reactome:R-HSA-192105|refseq:XP_011538905.1|refseq:XP_011538906.1|refseq:NP_078862.4|refseq:NP_683702.1|refseq:NP_683703.1|refseq:NP_683705.1|refseq:NP_683706.3|refseq:NP_683704.2|refseq:NP_683707.3|refseq:XP_006710386.1|refseq:XP_006710387.1|refseq:XP_006710388.1|refseq:XP_006710389.1|refseq:NP_001317509.1|refseq:XP_016855708.1|refseq:XP_016855709.1|refseq:XP_016855710.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2021/11/30 rogid:OSJLLFBf1ofw8SC01p2iiIM1oJo9606 rogid:2XLQ0JD4BEKGoyiwd/63YTmyVlE9606 intact-crc:F03843AD8CE15831|rigid:IMJbqoiSzxb7cKQYWRYWV8k10c0 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P51784 uniprotkb:Q8NCJ5 intact:EBI-306876|intact:EBI-1058416|uniprotkb:Q8IUG6|uniprotkb:Q9BWE1|uniprotkb:B2RTX1|ensembl:ENSP00000218348 intact:EBI-2511300|ensembl:ENSP00000301463|uniprotkb:Q96SK5|uniprotkb:B9EG99 psi-mi:ubp11_human(display_long)|uniprotkb:USP11(gene name)|psi-mi:USP11(display_short)|uniprotkb:UHX1(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 11(gene name synonym)|uniprotkb:Deubiquitinating enzyme 11(gene name synonym)|uniprotkb:Ubiquitin thioesterase 11(gene name synonym) psi-mi:spry3_human(display_long)|uniprotkb:SPRYD3(gene name)|psi-mi:SPRYD3(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511298|imex:IM-12079-66 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000102226(gene)|ensembl:ENST00000218348(transcript)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR018200|interpro:IPR028135|interpro:IPR028889|interpro:IPR029346|interpro:IPR035927|interpro:IPR038765|mint:P51784|rcsb pdb:4MEL|rcsb pdb:5OK6|reactome:R-HSA-390471|reactome:R-HSA-5689880|refseq:NP_004642.2|refseq:XP_011542290.1|refseq:XP_005272731.1|dip:DIP-27567N ensembl:ENSG00000167778(gene)|ensembl:ENST00000301463(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007166"(cell surface receptor signaling pathway)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR035783|interpro:IPR043136|mint:Q8NCJ5|rcsb pdb:2YYO|refseq:NP_116229.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2021/11/30 rogid:OSJLLFBf1ofw8SC01p2iiIM1oJo9606 rogid:VbqJ033T2QVGIuwYdCf+WHIiaJ89606 intact-crc:F03843AD8CE15831|rigid:IMJbqoiSzxb7cKQYWRYWV8k10c0 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P51784 uniprotkb:Q9H3H9 intact:EBI-306876|intact:EBI-1058416|uniprotkb:Q8IUG6|uniprotkb:Q9BWE1|uniprotkb:B2RTX1|ensembl:ENSP00000218348 intact:EBI-2511339|ensembl:ENSP00000332359|ensembl:ENSP00000361866|uniprotkb:B2R5C7 psi-mi:ubp11_human(display_long)|uniprotkb:USP11(gene name)|psi-mi:USP11(display_short)|uniprotkb:UHX1(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 11(gene name synonym)|uniprotkb:Deubiquitinating enzyme 11(gene name synonym)|uniprotkb:Ubiquitin thioesterase 11(gene name synonym) psi-mi:tcal2_human(display_long)|uniprotkb:TCEAL2(gene name)|psi-mi:TCEAL2(display_short)|uniprotkb:Transcription elongation factor S-II protein-like 2(gene name synonym)|uniprotkb:My048(orf name)|uniprotkb:MY0876G0(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511298|imex:IM-12079-66 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000102226(gene)|ensembl:ENST00000218348(transcript)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR018200|interpro:IPR028135|interpro:IPR028889|interpro:IPR029346|interpro:IPR035927|interpro:IPR038765|mint:P51784|rcsb pdb:4MEL|rcsb pdb:5OK6|reactome:R-HSA-390471|reactome:R-HSA-5689880|refseq:NP_004642.2|refseq:XP_011542290.1|refseq:XP_005272731.1|dip:DIP-27567N ensembl:ENSG00000184905(gene)|ensembl:ENST00000329035(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0050699"(WW domain binding)|interpro:IPR021156|ensembl:ENST00000372780(transcript)|refseq:NP_525129.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2021/11/30 rogid:OSJLLFBf1ofw8SC01p2iiIM1oJo9606 rogid:BWeVHwMqsKSxoC6cxyUUSika3Cc9606 intact-crc:F03843AD8CE15831|rigid:IMJbqoiSzxb7cKQYWRYWV8k10c0 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P51784 uniprotkb:P30260 intact:EBI-306876|intact:EBI-1058416|uniprotkb:Q8IUG6|uniprotkb:Q9BWE1|uniprotkb:B2RTX1|ensembl:ENSP00000218348 intact:EBI-994813|uniprotkb:Q16349|uniprotkb:Q96F35|ensembl:ENSP00000066544|uniprotkb:G3V1C4|intact:EBI-10972530 psi-mi:ubp11_human(display_long)|uniprotkb:USP11(gene name)|psi-mi:USP11(display_short)|uniprotkb:UHX1(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 11(gene name synonym)|uniprotkb:Deubiquitinating enzyme 11(gene name synonym)|uniprotkb:Ubiquitin thioesterase 11(gene name synonym) psi-mi:cdc27_human(display_long)|uniprotkb:CDC27(gene name)|psi-mi:CDC27(display_short)|uniprotkb:D0S1430E(gene name synonym)|uniprotkb:D17S978E(gene name synonym)|uniprotkb:CDC27 homolog(gene name synonym)|uniprotkb:H-NUC(gene name synonym)|uniprotkb:ANAPC3(gene name synonym)|uniprotkb:Anaphase-promoting complex subunit 3(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511298|imex:IM-12079-66 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000102226(gene)|ensembl:ENST00000218348(transcript)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR018200|interpro:IPR028135|interpro:IPR028889|interpro:IPR029346|interpro:IPR035927|interpro:IPR038765|mint:P51784|rcsb pdb:4MEL|rcsb pdb:5OK6|reactome:R-HSA-390471|reactome:R-HSA-5689880|refseq:NP_004642.2|refseq:XP_011542290.1|refseq:XP_005272731.1|dip:DIP-27567N ensembl:ENSG00000004897(gene)|ensembl:ENST00000066544(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0007091"(metaphase/anaphase transition of mitotic cell cycle)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0031145"(anaphase-promoting complex-dependent catabolic process)|go:"GO:0045842"(positive regulation of mitotic metaphase/anaphase transition)|go:"GO:0051301"(cell division)|go:"GO:0070979"(protein K11-linked ubiquitination)|go:"GO:0072686"(mitotic spindle)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|rcsb pdb:3T1N|go:"GO:0005680"(anaphase-promoting complex)|rcsb pdb:4RG6|rcsb pdb:4RG7|rcsb pdb:4RG9|rcsb pdb:4UI9|rcsb pdb:5A31|rcsb pdb:5G04|rcsb pdb:5G05|rcsb pdb:5KHR|rcsb pdb:5KHU|rcsb pdb:5L9T|rcsb pdb:5L9U|rcsb pdb:5LCW|rcsb pdb:6Q6G|rcsb pdb:6Q6H|rcsb pdb:6TLJ|rcsb pdb:6TM5|rcsb pdb:6TNT|reactome:R-HSA-141430|reactome:R-HSA-174048|reactome:R-HSA-174084|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-176407|reactome:R-HSA-176408|reactome:R-HSA-176409|reactome:R-HSA-176412|reactome:R-HSA-179409|reactome:R-HSA-2467813|reactome:R-HSA-2559582|reactome:R-HSA-69017|reactome:R-HSA-8853884|reactome:R-HSA-9687136|reactome:R-HSA-983168|refseq:NP_001107563.1|refseq:NP_001247.3|dip:DIP-36422N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2021/11/30 rogid:OSJLLFBf1ofw8SC01p2iiIM1oJo9606 rogid:YOrJCRal5ZfO7kP2b8FPon0Yytw9606 intact-crc:F03843AD8CE15831|rigid:IMJbqoiSzxb7cKQYWRYWV8k10c0 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P51784 uniprotkb:Q93009 intact:EBI-306876|intact:EBI-1058416|uniprotkb:Q8IUG6|uniprotkb:Q9BWE1|uniprotkb:B2RTX1|ensembl:ENSP00000218348 intact:EBI-302474|uniprotkb:A6NMY8|intact:EBI-28988230|ensembl:ENSP00000343535|uniprotkb:B7Z815|uniprotkb:H0Y3G8 psi-mi:ubp11_human(display_long)|uniprotkb:USP11(gene name)|psi-mi:USP11(display_short)|uniprotkb:UHX1(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 11(gene name synonym)|uniprotkb:Deubiquitinating enzyme 11(gene name synonym)|uniprotkb:Ubiquitin thioesterase 11(gene name synonym) psi-mi:ubp7_human(display_long)|uniprotkb:USP7(gene name)|psi-mi:USP7(display_short)|uniprotkb:HAUSP(gene name synonym)|uniprotkb:Ubiquitin thioesterase 7(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 7(gene name synonym)|uniprotkb:Deubiquitinating enzyme 7(gene name synonym)|uniprotkb:Herpesvirus-associated ubiquitin-specific protease(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511298|imex:IM-12079-66 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000102226(gene)|ensembl:ENST00000218348(transcript)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR018200|interpro:IPR028135|interpro:IPR028889|interpro:IPR029346|interpro:IPR035927|interpro:IPR038765|mint:P51784|rcsb pdb:4MEL|rcsb pdb:5OK6|reactome:R-HSA-390471|reactome:R-HSA-5689880|refseq:NP_004642.2|refseq:XP_011542290.1|refseq:XP_005272731.1|dip:DIP-27567N rcsb pdb:4PYZ|rcsb pdb:4WPH|rcsb pdb:4WPI|rcsb pdb:4YOC|rcsb pdb:4YSI|rcsb pdb:4Z96|rcsb pdb:4Z97|rcsb pdb:5C56|rcsb pdb:5C6D|rcsb pdb:5FWI|rcsb pdb:5GG4|rcsb pdb:5J7T|rcsb pdb:5JTJ|rcsb pdb:5JTV|rcsb pdb:5KYB|rcsb pdb:4M5X|rcsb pdb:5KYC|rcsb pdb:5KYD|rcsb pdb:5KYE|rcsb pdb:5KYF|interpro:IPR029346|interpro:IPR038765|mint:Q93009|rcsb pdb:1NB8|rcsb pdb:1NBF|rcsb pdb:1YY6|rcsb pdb:1YZE|rcsb pdb:2F1W|rcsb pdb:2F1X|rcsb pdb:2F1Y|rcsb pdb:2F1Z|rcsb pdb:2FOJ|rcsb pdb:2FOO|rcsb pdb:2FOP|rcsb pdb:2KVR|rcsb pdb:2XXN|rcsb pdb:2YLM|rcsb pdb:3MQR|rcsb pdb:3MQS|rcsb pdb:4JJQ|rcsb pdb:4KG9|rcsb pdb:4M5W|go:"GO:0006283"(transcription-coupled nucleotide-excision repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010216"(maintenance of DNA methylation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035520"(monoubiquitinated protein deubiquitination)|go:"GO:0035616"(histone H2B conserved C-terminal lysine deubiquitination)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0048511"(rhythmic process)|go:"GO:0050821"(protein stabilization)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0101005"(deubiquitinase activity)|go:"GO:1901537"(positive regulation of DNA demethylation)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1904353"(regulation of telomere capping)|go:"GO:1905279"(regulation of retrograde transport, endosome to Golgi)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR018200|interpro:IPR024729|interpro:IPR028889|ensembl:ENSG00000187555(gene)|ensembl:ENST00000344836(transcript)|go:"GO:0002039"(p53 binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0006111"(regulation of gluconeogenesis)|rcsb pdb:5N9R|rcsb pdb:5N9T|rcsb pdb:5NGE|rcsb pdb:5NGF|rcsb pdb:5UQV|rcsb pdb:5UQX|rcsb pdb:5VS6|rcsb pdb:5VSB|rcsb pdb:5VSK|rcsb pdb:5WHC|rcsb pdb:6F5H|rcsb pdb:6M1K|rcsb pdb:6P5L|rcsb pdb:6VN2|rcsb pdb:6VN3|rcsb pdb:6VN4|rcsb pdb:6VN5|rcsb pdb:6VN6|rcsb pdb:7CM2|reactome:R-HSA-5689880|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6804757|reactome:R-HSA-8866652|reactome:R-HSA-8948747|refseq:NP_001273386.1|refseq:NP_003461.2|refseq:NP_001308787.1|ensembl:ENSP00000343535|ensembl:ENST00000381886|ensembl:ENSP00000371310|dip:DIP-29053N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2021/11/30 rogid:OSJLLFBf1ofw8SC01p2iiIM1oJo9606 rogid:V+PXXBRM2zwlGQaeFiyjaQ9yf+A9606 intact-crc:F03843AD8CE15831|rigid:IMJbqoiSzxb7cKQYWRYWV8k10c0 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P51784 uniprotkb:Q6ICG6 intact:EBI-306876|intact:EBI-1058416|uniprotkb:Q8IUG6|uniprotkb:Q9BWE1|uniprotkb:B2RTX1|ensembl:ENSP00000218348 intact:EBI-1053969|uniprotkb:B0QY17|uniprotkb:B0QY19|uniprotkb:Q6ZVE5|uniprotkb:Q7Z6K9|uniprotkb:Q8IZ76|uniprotkb:Q9Y2E2|uniprotkb:B3KT48|ensembl:ENSP00000336720 psi-mi:ubp11_human(display_long)|uniprotkb:USP11(gene name)|psi-mi:USP11(display_short)|uniprotkb:UHX1(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 11(gene name synonym)|uniprotkb:Deubiquitinating enzyme 11(gene name synonym)|uniprotkb:Ubiquitin thioesterase 11(gene name synonym) psi-mi:k0930_human(display_long)|uniprotkb:KIAA0930(gene name)|psi-mi:KIAA0930(display_short)|uniprotkb:C22orf9(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511298|imex:IM-12079-66 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000102226(gene)|ensembl:ENST00000218348(transcript)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR018200|interpro:IPR028135|interpro:IPR028889|interpro:IPR029346|interpro:IPR035927|interpro:IPR038765|mint:P51784|rcsb pdb:4MEL|rcsb pdb:5OK6|reactome:R-HSA-390471|reactome:R-HSA-5689880|refseq:NP_004642.2|refseq:XP_011542290.1|refseq:XP_005272731.1|dip:DIP-27567N refseq:NP_001009880.1|refseq:NP_056079.1|refseq:XP_011528319.1|ensembl:ENSG00000100364(gene)|ensembl:ENST00000336156(transcript)|interpro:IPR019141|mint:Q6ICG6 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2021/11/30 rogid:OSJLLFBf1ofw8SC01p2iiIM1oJo9606 rogid:A+3Ru/L5B0a2Vz/mw+rp0atVvLE9606 intact-crc:F03843AD8CE15831|rigid:IMJbqoiSzxb7cKQYWRYWV8k10c0 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P51784 uniprotkb:Q96G74 intact:EBI-306876|intact:EBI-1058416|uniprotkb:Q8IUG6|uniprotkb:Q9BWE1|uniprotkb:B2RTX1|ensembl:ENSP00000218348 intact:EBI-723849|ensembl:ENSP00000156084|uniprotkb:Q4KMN9|uniprotkb:Q8N6T5|uniprotkb:Q9H650|uniprotkb:Q9H9U0|uniprotkb:Q9NT65|uniprotkb:G5E9D7|uniprotkb:B4DGG7 psi-mi:ubp11_human(display_long)|uniprotkb:USP11(gene name)|psi-mi:USP11(display_short)|uniprotkb:UHX1(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 11(gene name synonym)|uniprotkb:Deubiquitinating enzyme 11(gene name synonym)|uniprotkb:Ubiquitin thioesterase 11(gene name synonym) psi-mi:otud5_human(display_long)|uniprotkb:Deubiquitinating enzyme A(gene name synonym)|uniprotkb:OTUD5(gene name)|psi-mi:OTUD5(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511298|imex:IM-12079-66 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000102226(gene)|ensembl:ENST00000218348(transcript)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR018200|interpro:IPR028135|interpro:IPR028889|interpro:IPR029346|interpro:IPR035927|interpro:IPR038765|mint:P51784|rcsb pdb:4MEL|rcsb pdb:5OK6|reactome:R-HSA-390471|reactome:R-HSA-5689880|refseq:NP_004642.2|refseq:XP_011542290.1|refseq:XP_005272731.1|dip:DIP-27567N refseq:NP_001129629.1|refseq:NP_001129630.1|refseq:NP_060072.1|ensembl:ENSG00000068308(gene)|ensembl:ENST00000156084(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005829"(cytosol)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0061578"(Lys63-specific deubiquitinase activity)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0101005"(deubiquitinase activity)|go:"GO:1904263"(positive regulation of TORC1 signaling)|go:"GO:1904515"(positive regulation of TORC2 signaling)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR003323(Ovarian tumour, otubain)|interpro:IPR031084|interpro:IPR038765|rcsb pdb:3PFY|rcsb pdb:3TMO|rcsb pdb:3TMP|go:"GO:0032480"(negative regulation of type I interferon production)|reactome:R-HSA-5689896|reactome:R-HSA-936440|refseq:NP_001129631.1|refseq:XP_006724600.1|dip:DIP-53541N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2021/11/30 rogid:OSJLLFBf1ofw8SC01p2iiIM1oJo9606 rogid:wyLs+EQs9u1cdJPnFBJSKKilZjw9606 intact-crc:F03843AD8CE15831|rigid:IMJbqoiSzxb7cKQYWRYWV8k10c0 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P51784 uniprotkb:Q15170 intact:EBI-306876|intact:EBI-1058416|uniprotkb:Q8IUG6|uniprotkb:Q9BWE1|uniprotkb:B2RTX1|ensembl:ENSP00000218348 intact:EBI-2511314|uniprotkb:Q9UJQ9|intact:EBI-11156070 psi-mi:ubp11_human(display_long)|uniprotkb:USP11(gene name)|psi-mi:USP11(display_short)|uniprotkb:UHX1(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 11(gene name synonym)|uniprotkb:Deubiquitinating enzyme 11(gene name synonym)|uniprotkb:Ubiquitin thioesterase 11(gene name synonym) psi-mi:tcal1_human(display_long)|uniprotkb:TCEAL1(gene name)|psi-mi:TCEAL1(display_short)|uniprotkb:SIIR(gene name synonym)|uniprotkb:Transcription elongation factor S-II protein-like 1(gene name synonym)|uniprotkb:Nuclear phosphoprotein p21/SIIR(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511298|imex:IM-12079-66 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000102226(gene)|ensembl:ENST00000218348(transcript)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR018200|interpro:IPR028135|interpro:IPR028889|interpro:IPR029346|interpro:IPR035927|interpro:IPR038765|mint:P51784|rcsb pdb:4MEL|rcsb pdb:5OK6|reactome:R-HSA-390471|reactome:R-HSA-5689880|refseq:NP_004642.2|refseq:XP_011542290.1|refseq:XP_005272731.1|dip:DIP-27567N go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0050699"(WW domain binding)|interpro:IPR021156|interpro:IPR010370(Transcription elongation factor A, SII-related)|mint:Q15170 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2021/11/30 rogid:OSJLLFBf1ofw8SC01p2iiIM1oJo9606 rogid:QGQDFZmacLSo79K+UBfW/ulS32E9606 intact-crc:F03843AD8CE15831|rigid:IMJbqoiSzxb7cKQYWRYWV8k10c0 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75317 uniprotkb:Q12769 intact:EBI-2511507|ensembl:ENSP00000282344|uniprotkb:Q8TC49|uniprotkb:Q5VZV3|uniprotkb:A8K0X0 intact:EBI-295715|uniprotkb:Q96GB3|uniprotkb:Q9H660|uniprotkb:B4DYE8|uniprotkb:B4E2J9|uniprotkb:Q08AD3|uniprotkb:Q7Z5X6|intact:EBI-2563140|ensembl:ENSP00000367721 psi-mi:ubp12_human(display_long)|uniprotkb:USP12(gene name)|psi-mi:USP12(display_short)|uniprotkb:UBH1(gene name synonym)|uniprotkb:USP12L1(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 12(gene name synonym)|uniprotkb:Deubiquitinating enzyme 12(gene name synonym)|uniprotkb:Ubiquitin-hydrolyzing enzyme 1(gene name synonym)|uniprotkb:Ubiquitin thioesterase 12(gene name synonym) psi-mi:nu160_human(display_long)|uniprotkb:NUP160(gene name)|psi-mi:NUP160(display_short)|uniprotkb:KIAA0197(gene name synonym)|uniprotkb:NUP120(gene name synonym)|uniprotkb:Nucleoporin Nup160(gene name synonym)|uniprotkb:160 kDa nucleoporin(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511514|imex:IM-12079-16 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000152484(gene)|ensembl:ENST00000282344(transcript)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0046872"(metal ion binding)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|mint:O75317|rcsb pdb:5K16|rcsb pdb:5K1A|rcsb pdb:5K1B|rcsb pdb:5K1C|rcsb pdb:5L8W|reactome:R-HSA-5689880|refseq:NP_872294.2 refseq:NP_056046.1|refseq:NP_001305328.1|dip:DIP-31262N|ensembl:ENSG00000030066(gene)|ensembl:ENST00000378460(transcript)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005643"(nuclear pore)|go:"GO:0005829"(cytosol)|go:"GO:0006406"(mRNA export from nucleus)|go:"GO:0015031"(protein transport)|go:"GO:0017056"(structural constituent of nuclear pore)|go:"GO:0031080"(nuclear pore outer ring)|go:"GO:0072006"(nephron development)|interpro:IPR021717|mint:Q12769|rcsb pdb:5A9Q|reactome:R-HSA-1169408|reactome:R-HSA-141444|reactome:R-HSA-159227|reactome:R-HSA-159230|reactome:R-HSA-159231|reactome:R-HSA-159236|reactome:R-HSA-165054|reactome:R-HSA-168271|reactome:R-HSA-168276|reactome:R-HSA-168325|reactome:R-HSA-168333|reactome:R-HSA-170822|reactome:R-HSA-180746|reactome:R-HSA-180910|reactome:R-HSA-191859|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-3108214|reactome:R-HSA-3232142|reactome:R-HSA-3301854|reactome:R-HSA-3371453|reactome:R-HSA-4085377|reactome:R-HSA-4551638|reactome:R-HSA-4570464|reactome:R-HSA-4615885|reactome:R-HSA-5578749|reactome:R-HSA-5619107|reactome:R-HSA-5663220|reactome:R-HSA-6784531|reactome:R-HSA-68877|reactome:R-HSA-9609690|reactome:R-HSA-9610379|reactome:R-HSA-9615933|reactome:R-HSA-9648025 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:SiueMBicjAsFl2OGlBfQ6tg1cf89606 rogid:15tRpv4+wvw31oJPxM42NxWdRUc9606 intact-crc:58F10736B8C44E96|rigid:l7bhkOXQj6mPE/nmBoFlvDxGgjY false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75317 uniprotkb:Q6ZVD8 intact:EBI-2511507|ensembl:ENSP00000282344|uniprotkb:Q8TC49|uniprotkb:Q5VZV3|uniprotkb:A8K0X0 intact:EBI-2511496|uniprotkb:Q9NV17|uniprotkb:Q9Y2E3|uniprotkb:A1L374|ensembl:ENSP00000457991 psi-mi:ubp12_human(display_long)|uniprotkb:USP12(gene name)|psi-mi:USP12(display_short)|uniprotkb:UBH1(gene name synonym)|uniprotkb:USP12L1(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 12(gene name synonym)|uniprotkb:Deubiquitinating enzyme 12(gene name synonym)|uniprotkb:Ubiquitin-hydrolyzing enzyme 1(gene name synonym)|uniprotkb:Ubiquitin thioesterase 12(gene name synonym) psi-mi:phlp2_human(display_long)|uniprotkb:PHLPP2(gene name)|psi-mi:PHLPP2(display_short)|uniprotkb:KIAA0931(gene name synonym)|uniprotkb:PHLPPL(gene name synonym)|uniprotkb:PH domain leucine-rich repeat-containing protein phosphatase-like(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511514|imex:IM-12079-16 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000152484(gene)|ensembl:ENST00000282344(transcript)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0046872"(metal ion binding)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|mint:O75317|rcsb pdb:5K16|rcsb pdb:5K1A|rcsb pdb:5K1B|rcsb pdb:5K1C|rcsb pdb:5L8W|reactome:R-HSA-5689880|refseq:NP_872294.2 refseq:NP_001275932.1|refseq:NP_055835.2|dip:DIP-53556N|ensembl:ENSG00000040199(gene)|ensembl:ENST00000568954(transcript)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0021766"(hippocampus development)|go:"GO:0042622"(photoreceptor outer segment membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045171"(intercellular bridge)|go:"GO:0046872"(metal ion binding)|go:"GO:0072686"(mitotic spindle)|go:"GO:0106306"|go:"GO:0106307"|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR001932(Protein phosphatase 2C-related)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR032675|interpro:IPR036457|reactome:R-HSA-199418 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:SiueMBicjAsFl2OGlBfQ6tg1cf89606 rogid:Z6e8RRJ8TleJRWTlecN3DNu1Ums9606 intact-crc:58F10736B8C44E96|rigid:l7bhkOXQj6mPE/nmBoFlvDxGgjY false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75317 uniprotkb:Q8WUW6 intact:EBI-2511507|ensembl:ENSP00000282344|uniprotkb:Q8TC49|uniprotkb:Q5VZV3|uniprotkb:A8K0X0 intact:EBI-2511492 psi-mi:ubp12_human(display_long)|uniprotkb:USP12(gene name)|psi-mi:USP12(display_short)|uniprotkb:UBH1(gene name synonym)|uniprotkb:USP12L1(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 12(gene name synonym)|uniprotkb:Deubiquitinating enzyme 12(gene name synonym)|uniprotkb:Ubiquitin-hydrolyzing enzyme 1(gene name synonym)|uniprotkb:Ubiquitin thioesterase 12(gene name synonym) psi-mi:q8wuw6_human(display_long)|uniprotkb:DMWD(gene name)|psi-mi:DMWD(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511514|imex:IM-12079-16 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000152484(gene)|ensembl:ENST00000282344(transcript)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0046872"(metal ion binding)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|mint:O75317|rcsb pdb:5K16|rcsb pdb:5K1A|rcsb pdb:5K1B|rcsb pdb:5K1C|rcsb pdb:5L8W|reactome:R-HSA-5689880|refseq:NP_872294.2 interpro:IPR001680(WD40 repeat)|refseq:NP_004934.1|interpro:IPR036322 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:SiueMBicjAsFl2OGlBfQ6tg1cf89606 rogid:p6gBB9R1MgufUro2moLk1bzduC49606 intact-crc:58F10736B8C44E96|rigid:l7bhkOXQj6mPE/nmBoFlvDxGgjY false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75317 uniprotkb:Q9Y5K5 intact:EBI-2511507|ensembl:ENSP00000282344|uniprotkb:Q8TC49|uniprotkb:Q5VZV3|uniprotkb:A8K0X0 intact:EBI-1051183|uniprotkb:Q5LJA6|uniprotkb:Q5LJA7|uniprotkb:Q8TBS4|uniprotkb:Q96BJ9|uniprotkb:Q9H1W5|uniprotkb:Q9P0I3|uniprotkb:Q9UQN2|ensembl:ENSP00000356425 psi-mi:ubp12_human(display_long)|uniprotkb:USP12(gene name)|psi-mi:USP12(display_short)|uniprotkb:UBH1(gene name synonym)|uniprotkb:USP12L1(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 12(gene name synonym)|uniprotkb:Deubiquitinating enzyme 12(gene name synonym)|uniprotkb:Ubiquitin-hydrolyzing enzyme 1(gene name synonym)|uniprotkb:Ubiquitin thioesterase 12(gene name synonym) psi-mi:uchl5_human(display_long)|uniprotkb:Ubiquitin thioesterase L5(gene name synonym)|uniprotkb:Ubiquitin C-terminal hydrolase UCH37(gene name synonym)|uniprotkb:UCHL5(gene name)|psi-mi:UCHL5(display_short)|uniprotkb:UCH37(gene name synonym)|uniprotkb:AD-019(orf name)|uniprotkb:CGI-70(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511514|imex:IM-12079-16 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000152484(gene)|ensembl:ENST00000282344(transcript)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0046872"(metal ion binding)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|mint:O75317|rcsb pdb:5K16|rcsb pdb:5K1A|rcsb pdb:5K1B|rcsb pdb:5K1C|rcsb pdb:5L8W|reactome:R-HSA-5689880|refseq:NP_872294.2 refseq:NP_001186190.1|refseq:NP_001186191.1|refseq:NP_001186192.1|refseq:NP_057068.1|ensembl:ENSG00000116750(gene)|ensembl:ENST00000367455(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0021670"(lateral ventricle development)|go:"GO:0030901"(midbrain development)|go:"GO:0031011"(Ino80 complex)|go:"GO:0031597"(cytosolic proteasome complex)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0048853"(forebrain morphogenesis)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070628"(proteasome binding)|interpro:IPR001578(Peptidase C12, ubiquitin carboxyl-terminal hydrolase 1)|interpro:IPR017390(Ubiquitinyl hydrolase, UCH37 type)|interpro:IPR033837|interpro:IPR036959|interpro:IPR038765|interpro:IPR041507|mint:Q9Y5K5|rcsb pdb:3A7S|rcsb pdb:3IHR|rcsb pdb:3RII|rcsb pdb:3RIS|rcsb pdb:3TB3|rcsb pdb:4UEL|rcsb pdb:4UEM|rcsb pdb:4UF5|rcsb pdb:4UF6|rcsb pdb:4WLP|reactome:R-HSA-2173788|reactome:R-HSA-5689603|dip:DIP-42671N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:SiueMBicjAsFl2OGlBfQ6tg1cf89606 rogid:gRm5ttq5Tc0cBIOQ1ut2ugzbMTY9606 intact-crc:58F10736B8C44E96|rigid:l7bhkOXQj6mPE/nmBoFlvDxGgjY false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75317 uniprotkb:Q8TAF3 intact:EBI-2511507|ensembl:ENSP00000282344|uniprotkb:Q8TC49|uniprotkb:Q5VZV3|uniprotkb:A8K0X0 intact:EBI-1045469|uniprotkb:Q63HJ2|uniprotkb:Q658Y1|uniprotkb:Q8N3Z1|uniprotkb:Q9NSK8|uniprotkb:Q9P279|uniprotkb:B4DM86|uniprotkb:B4DQI2|uniprotkb:B4DY84|ensembl:ENSP00000307491 psi-mi:ubp12_human(display_long)|uniprotkb:USP12(gene name)|psi-mi:USP12(display_short)|uniprotkb:UBH1(gene name synonym)|uniprotkb:USP12L1(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 12(gene name synonym)|uniprotkb:Deubiquitinating enzyme 12(gene name synonym)|uniprotkb:Ubiquitin-hydrolyzing enzyme 1(gene name synonym)|uniprotkb:Ubiquitin thioesterase 12(gene name synonym) psi-mi:wdr48_human(display_long)|uniprotkb:WD repeat endosomal protein(gene name synonym)|uniprotkb:p80(gene name synonym)|uniprotkb:WDR48(gene name)|psi-mi:WDR48(display_short)|uniprotkb:KIAA1449(gene name synonym)|uniprotkb:UAF1(gene name synonym)|uniprotkb:USP1-associated factor 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511514|imex:IM-12079-16 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000152484(gene)|ensembl:ENST00000282344(transcript)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0046872"(metal ion binding)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|mint:O75317|rcsb pdb:5K16|rcsb pdb:5K1A|rcsb pdb:5K1B|rcsb pdb:5K1C|rcsb pdb:5L8W|reactome:R-HSA-5689880|refseq:NP_872294.2 refseq:NP_065890.1|ensembl:ENSG00000114742(gene)|ensembl:ENST00000302313(transcript)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0003677"(DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043588"(skin development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0072520"(seminiferous tubule development)|go:"GO:1902525"(regulation of protein monoubiquitination)|go:"GO:1903003"(positive regulation of protein deubiquitination)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR021772|interpro:IPR036322|mint:Q8TAF3|rcsb pdb:5CVL|rcsb pdb:5CVN|rcsb pdb:5CVO|rcsb pdb:5K1A|rcsb pdb:5K1B|rcsb pdb:5K1C|rcsb pdb:5L8E|rcsb pdb:5L8W|rcsb pdb:6JLQ|rcsb pdb:7AY0|rcsb pdb:7AY1|rcsb pdb:7AY2|reactome:R-HSA-110314|reactome:R-HSA-5689880|reactome:R-HSA-6783310|reactome:R-HSA-9673766|refseq:NP_001290331.1|refseq:NP_001290332.1|refseq:NP_001333156.1|refseq:NP_001333157.1|dip:DIP-50841N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:SiueMBicjAsFl2OGlBfQ6tg1cf89606 rogid:S8ihl3jxEEyMS46AM2ynXSFfCU49606 intact-crc:58F10736B8C44E96|rigid:l7bhkOXQj6mPE/nmBoFlvDxGgjY false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75317 uniprotkb:P08253 intact:EBI-2511507|ensembl:ENSP00000282344|uniprotkb:Q8TC49|uniprotkb:Q5VZV3|uniprotkb:A8K0X0 intact:EBI-1033518|uniprotkb:B2R6U1|uniprotkb:Q9UCJ8|ensembl:ENSP00000219070|uniprotkb:E9PE45|uniprotkb:B4DWH3 psi-mi:ubp12_human(display_long)|uniprotkb:USP12(gene name)|psi-mi:USP12(display_short)|uniprotkb:UBH1(gene name synonym)|uniprotkb:USP12L1(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 12(gene name synonym)|uniprotkb:Deubiquitinating enzyme 12(gene name synonym)|uniprotkb:Ubiquitin-hydrolyzing enzyme 1(gene name synonym)|uniprotkb:Ubiquitin thioesterase 12(gene name synonym) psi-mi:mmp2_human(display_long)|uniprotkb:MMP2(gene name)|psi-mi:MMP2(display_short)|uniprotkb:CLG4A(gene name synonym)|uniprotkb:72 kDa gelatinase(gene name synonym)|uniprotkb:Matrix metalloproteinase-2(gene name synonym)|uniprotkb:Gelatinase A(gene name synonym)|uniprotkb:TBE-1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511514|imex:IM-12079-16 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000152484(gene)|ensembl:ENST00000282344(transcript)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0046872"(metal ion binding)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|mint:O75317|rcsb pdb:5K16|rcsb pdb:5K1A|rcsb pdb:5K1B|rcsb pdb:5K1C|rcsb pdb:5L8W|reactome:R-HSA-5689880|refseq:NP_872294.2 refseq:NP_001289437.1|refseq:NP_001289438.1|refseq:NP_001289439.1|ensembl:ENSG00000087245(gene)|ensembl:ENST00000219070(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001955"(blood vessel maturation)|go:"GO:0001957"(intramembranous ossification)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005886"(plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0007566"(embryo implantation)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0030017"(sarcomere)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030574"(collagen catabolic process)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0044267"(cellular protein metabolic process)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048771"(tissue remodeling)|go:"GO:0060325"(face morphogenesis)|go:"GO:0060346"(bone trabecula formation)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071492"(cellular response to UV-A)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|interpro:IPR000562(Type II fibronectin, collagen-binding)|interpro:IPR000585(Hemopexin)|interpro:IPR001818(Peptidase M10A and M12B, matrixin and adamalysin)|interpro:IPR002477(Peptidoglycan binding-like)|interpro:IPR006026(Peptidase, metallopeptidases)|interpro:IPR013806(Kringle-like fold)|interpro:IPR018486|interpro:IPR018487|interpro:IPR021158|interpro:IPR021190|interpro:IPR024079|interpro:IPR028708|interpro:IPR033739|interpro:IPR036365|interpro:IPR036375|interpro:IPR036943|rcsb pdb:1CK7|rcsb pdb:1CXW|rcsb pdb:1EAK|rcsb pdb:1GEN|rcsb pdb:1GXD|rcsb pdb:1HOV|rcsb pdb:1J7M|rcsb pdb:1KS0|rcsb pdb:1QIB|rcsb pdb:1RTG|rcsb pdb:3AYU|reactome:R-HSA-1442490|reactome:R-HSA-1474228|reactome:R-HSA-1592389|reactome:R-HSA-381426|reactome:R-HSA-3928665|reactome:R-HSA-6785807|reactome:R-HSA-9009391|refseq:NP_001121363.1|refseq:NP_004521.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:SiueMBicjAsFl2OGlBfQ6tg1cf89606 rogid:s0IHoSkzT9GNfkkLZsVsV7cIf1g9606 intact-crc:58F10736B8C44E96|rigid:l7bhkOXQj6mPE/nmBoFlvDxGgjY false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75317 uniprotkb:O60346 intact:EBI-2511507|ensembl:ENSP00000282344|uniprotkb:Q8TC49|uniprotkb:Q5VZV3|uniprotkb:A8K0X0 intact:EBI-2511516|intact:EBI-28974360|ensembl:ENSP00000262719|uniprotkb:Q6PJI6|uniprotkb:Q6P4C4|uniprotkb:A1A4F5|uniprotkb:Q641Q7|uniprotkb:Q86TN6|uniprotkb:Q96FK2|uniprotkb:Q9NUY1 psi-mi:ubp12_human(display_long)|uniprotkb:USP12(gene name)|psi-mi:USP12(display_short)|uniprotkb:UBH1(gene name synonym)|uniprotkb:USP12L1(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 12(gene name synonym)|uniprotkb:Deubiquitinating enzyme 12(gene name synonym)|uniprotkb:Ubiquitin-hydrolyzing enzyme 1(gene name synonym)|uniprotkb:Ubiquitin thioesterase 12(gene name synonym) psi-mi:phlp1_human(display_long)|uniprotkb:PHLPP1(gene name)|psi-mi:PHLPP1(display_short)|uniprotkb:KIAA0606(gene name synonym)|uniprotkb:PHLPP(gene name synonym)|uniprotkb:PLEKHE1(gene name synonym)|uniprotkb:SCOP(gene name synonym)|uniprotkb:Pleckstrin homology domain-containing family E member 1(gene name synonym)|uniprotkb:Suprachiasmatic nucleus circadian oscillatory protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511514|imex:IM-12079-16 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000152484(gene)|ensembl:ENST00000282344(transcript)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0046872"(metal ion binding)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|mint:O75317|rcsb pdb:5K16|rcsb pdb:5K1A|rcsb pdb:5K1B|rcsb pdb:5K1C|rcsb pdb:5L8W|reactome:R-HSA-5689880|refseq:NP_872294.2 ensembl:ENSP00000262719|go:"GO:0009649"(entrainment of circadian clock)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046872"(metal ion binding)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1900744"(regulation of p38MAPK cascade)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001932(Protein phosphatase 2C-related)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR032675|interpro:IPR036457|mint:O60346|reactome:R-HSA-199418|ensembl:ENSG00000081913(gene)|ensembl:ENST00000262719(transcript)|go:"GO:0002667"(regulation of T cell anergy)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|refseq:NP_919431.2 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:SiueMBicjAsFl2OGlBfQ6tg1cf89606 rogid:hPGjeSVMlJhO3o9YBWoBm9xppfk9606 intact-crc:58F10736B8C44E96|rigid:l7bhkOXQj6mPE/nmBoFlvDxGgjY false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75317 uniprotkb:Q9H074 intact:EBI-2511507|ensembl:ENSP00000282344|uniprotkb:Q8TC49|uniprotkb:Q5VZV3|uniprotkb:A8K0X0 intact:EBI-81519|uniprotkb:O60455|uniprotkb:Q96B61|uniprotkb:Q9BS63|intact:EBI-28983264|ensembl:ENSP00000302768|intact:EBI-11149865|uniprotkb:A6NKV8 psi-mi:ubp12_human(display_long)|uniprotkb:USP12(gene name)|psi-mi:USP12(display_short)|uniprotkb:UBH1(gene name synonym)|uniprotkb:USP12L1(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 12(gene name synonym)|uniprotkb:Deubiquitinating enzyme 12(gene name synonym)|uniprotkb:Ubiquitin-hydrolyzing enzyme 1(gene name synonym)|uniprotkb:Ubiquitin thioesterase 12(gene name synonym) psi-mi:paip1_human(display_long)|uniprotkb:PAIP1(gene name)|psi-mi:PAIP1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511514|imex:IM-12079-16 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000152484(gene)|ensembl:ENST00000282344(transcript)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0046872"(metal ion binding)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|mint:O75317|rcsb pdb:5K16|rcsb pdb:5K1A|rcsb pdb:5K1B|rcsb pdb:5K1C|rcsb pdb:5L8W|reactome:R-HSA-5689880|refseq:NP_872294.2 refseq:NP_006442.2|refseq:NP_877590.1|refseq:NP_899152.1|rcsb pdb:1JH4|rcsb pdb:3NTW|rcsb pdb:3RK6|rcsb pdb:6YXJ|reactome:R-HSA-429947|mint:Q9H074|ensembl:ENSG00000172239(gene)|ensembl:ENST00000306846(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006413"(translational initiation)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0008494"(translation activator activity)|go:"GO:0048255"(mRNA stabilization)|interpro:IPR003890(MIF4G-like, type 3)|interpro:IPR009818(Ataxin-2, C-terminal)|interpro:IPR016021(MIF4-like, type 1/2/3)|interpro:IPR016024(Armadillo-type fold)|refseq:XP_016864445.1|ensembl:ENSP00000339622|ensembl:ENST00000436644|ensembl:ENSP00000387729|ensembl:ENST00000338972|ensembl:ENSP00000302768|refseq:XP_005248287.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:SiueMBicjAsFl2OGlBfQ6tg1cf89606 rogid:KPInpN26l8XAnUKFawoVUhwKM9w9606 intact-crc:58F10736B8C44E96|rigid:l7bhkOXQj6mPE/nmBoFlvDxGgjY false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75317 uniprotkb:Q9BRK5 intact:EBI-2511507|ensembl:ENSP00000282344|uniprotkb:Q8TC49|uniprotkb:Q5VZV3|uniprotkb:A8K0X0 intact:EBI-1389808|uniprotkb:Q8NBQ3|uniprotkb:Q9NZP7|uniprotkb:B1AME5|uniprotkb:B2RDF1|uniprotkb:B4DSM1|uniprotkb:Q53G52|uniprotkb:Q53HQ9|uniprotkb:Q96AA1|uniprotkb:Q9UN53|intact:EBI-2511482|uniprotkb:B1AME6 psi-mi:ubp12_human(display_long)|uniprotkb:USP12(gene name)|psi-mi:USP12(display_short)|uniprotkb:UBH1(gene name synonym)|uniprotkb:USP12L1(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 12(gene name synonym)|uniprotkb:Deubiquitinating enzyme 12(gene name synonym)|uniprotkb:Ubiquitin-hydrolyzing enzyme 1(gene name synonym)|uniprotkb:Ubiquitin thioesterase 12(gene name synonym) psi-mi:cab45_human(display_long)|uniprotkb:Stromal cell-derived factor 4(gene name synonym)|uniprotkb:SDF4(gene name)|psi-mi:SDF4(display_short)|uniprotkb:CAB45(gene name synonym)|uniprotkb:PSEC0034(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511514|imex:IM-12079-16 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000152484(gene)|ensembl:ENST00000282344(transcript)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0046872"(metal ion binding)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|mint:O75317|rcsb pdb:5K16|rcsb pdb:5K1A|rcsb pdb:5K1B|rcsb pdb:5K1C|rcsb pdb:5L8W|reactome:R-HSA-5689880|refseq:NP_872294.2 refseq:NP_057631.1|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR002048(Calcium-binding EF-hand)|refseq:XP_011539858.1|interpro:IPR027240|mint:Q9BRK5|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0009650"(UV protection)|go:"GO:0016020"(membrane)|go:"GO:0017156"(calcium-ion regulated exocytosis)|go:"GO:0021549"(cerebellum development)|go:"GO:0032059"(bleb)|go:"GO:0042802"(identical protein binding)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045471"(response to ethanol)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070625"(zymogen granule exocytosis)|go:"GO:0099558"(maintenance of synapse structure)|refseq:NP_057260.3 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:SiueMBicjAsFl2OGlBfQ6tg1cf89606 rogid:wQ0Ov1MDf6p0BmUCZRAS+Na/ERc9606 intact-crc:58F10736B8C44E96|rigid:l7bhkOXQj6mPE/nmBoFlvDxGgjY false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75317 uniprotkb:Q9P1S2 intact:EBI-2511507|ensembl:ENSP00000282344|uniprotkb:Q8TC49|uniprotkb:Q5VZV3|uniprotkb:A8K0X0 intact:EBI-2511504 psi-mi:ubp12_human(display_long)|uniprotkb:USP12(gene name)|psi-mi:USP12(display_short)|uniprotkb:UBH1(gene name synonym)|uniprotkb:USP12L1(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 12(gene name synonym)|uniprotkb:Deubiquitinating enzyme 12(gene name synonym)|uniprotkb:Ubiquitin-hydrolyzing enzyme 1(gene name synonym)|uniprotkb:Ubiquitin thioesterase 12(gene name synonym) psi-mi:q9p1s2_human(display_long) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511514|imex:IM-12079-16 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000152484(gene)|ensembl:ENST00000282344(transcript)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0046872"(metal ion binding)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|mint:O75317|rcsb pdb:5K16|rcsb pdb:5K1A|rcsb pdb:5K1B|rcsb pdb:5K1C|rcsb pdb:5L8W|reactome:R-HSA-5689880|refseq:NP_872294.2 go:"GO:0051087"(chaperone binding)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR044563 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:SiueMBicjAsFl2OGlBfQ6tg1cf89606 rogid:+pC1prCcP9i/pilHXx1M2iZRojs9606 intact-crc:58F10736B8C44E96|rigid:l7bhkOXQj6mPE/nmBoFlvDxGgjY false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75317 uniprotkb:Q14562 intact:EBI-2511507|ensembl:ENSP00000282344|uniprotkb:Q8TC49|uniprotkb:Q5VZV3|uniprotkb:A8K0X0 intact:EBI-2511477|ensembl:ENSP00000262415|ensembl:ENSP00000496923 psi-mi:ubp12_human(display_long)|uniprotkb:USP12(gene name)|psi-mi:USP12(display_short)|uniprotkb:UBH1(gene name synonym)|uniprotkb:USP12L1(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 12(gene name synonym)|uniprotkb:Deubiquitinating enzyme 12(gene name synonym)|uniprotkb:Ubiquitin-hydrolyzing enzyme 1(gene name synonym)|uniprotkb:Ubiquitin thioesterase 12(gene name synonym) psi-mi:dhx8_human(display_long)|uniprotkb:DHX8(gene name)|psi-mi:DHX8(display_short)|uniprotkb:DDX8(gene name synonym)|uniprotkb:DEAH box protein 8(gene name synonym)|uniprotkb:RNA helicase HRH1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511514|imex:IM-12079-16 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000152484(gene)|ensembl:ENST00000282344(transcript)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0046872"(metal ion binding)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|mint:O75317|rcsb pdb:5K16|rcsb pdb:5K1A|rcsb pdb:5K1B|rcsb pdb:5K1C|rcsb pdb:5L8W|reactome:R-HSA-5689880|refseq:NP_872294.2 mint:Q14562|rcsb pdb:2EQS|rcsb pdb:3I4U|rcsb pdb:5MQF|rcsb pdb:5XJC|rcsb pdb:6HYS|rcsb pdb:6HYT|rcsb pdb:6HYU|rcsb pdb:6ICZ|rcsb pdb:6QDV|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005829"(cytosol)|go:"GO:0006396"(RNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0016604"(nuclear body)|go:"GO:0042802"(identical protein binding)|go:"GO:0071007"(U2-type catalytic step 2 spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:0000398"(mRNA splicing, via spliceosome)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR002464(DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site)|interpro:IPR003029(S1, RNA binding)|interpro:IPR007502(Helicase-associated region)|interpro:IPR011709(Region of unknown function DUF1605)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR022967|interpro:IPR027417|interpro:IPR044762|ensembl:ENSG00000067596(gene)|ensembl:ENST00000262415(transcript)|ensembl:ENST00000650571(transcript)|go:"GO:0000390"(spliceosomal complex disassembly)|refseq:NP_004932.1|refseq:NP_001289552.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:SiueMBicjAsFl2OGlBfQ6tg1cf89606 rogid:ZUmh+KApFNV5NKCq6dizDgnw/Dw9606 intact-crc:58F10736B8C44E96|rigid:l7bhkOXQj6mPE/nmBoFlvDxGgjY false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75317 uniprotkb:Q53GS9 intact:EBI-2511507|ensembl:ENSP00000282344|uniprotkb:Q8TC49|uniprotkb:Q5VZV3|uniprotkb:A8K0X0 intact:EBI-1044822|uniprotkb:Q6NX47|uniprotkb:Q96RK9|uniprotkb:Q9BV89|uniprotkb:Q9H381|uniprotkb:Q9P050|uniprotkb:Q9Y310|uniprotkb:A8K086|ensembl:ENSP00000312981|ensembl:ENSP00000386864|uniprotkb:D6W5L4|intact:EBI-2557627|uniprotkb:B4DHT4|uniprotkb:B3KM40|uniprotkb:G5E9H0 psi-mi:ubp12_human(display_long)|uniprotkb:USP12(gene name)|psi-mi:USP12(display_short)|uniprotkb:UBH1(gene name synonym)|uniprotkb:USP12L1(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 12(gene name synonym)|uniprotkb:Deubiquitinating enzyme 12(gene name synonym)|uniprotkb:Ubiquitin-hydrolyzing enzyme 1(gene name synonym)|uniprotkb:Ubiquitin thioesterase 12(gene name synonym) psi-mi:snut2_human(display_long)|uniprotkb:U4/U6.U5 tri-snRNP-associated 65 kDa protein(gene name synonym)|uniprotkb:Inactive ubiquitin-specific peptidase 39(gene name synonym)|uniprotkb:SAD1 homolog(gene name synonym)|uniprotkb:USP39(gene name)|psi-mi:USP39(display_short)|uniprotkb:CGI-21(orf name)|uniprotkb:HSPC332(orf name)|uniprotkb:PRO2855(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511514|imex:IM-12079-16 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000152484(gene)|ensembl:ENST00000282344(transcript)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0046872"(metal ion binding)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|mint:O75317|rcsb pdb:5K16|rcsb pdb:5K1A|rcsb pdb:5K1B|rcsb pdb:5K1C|rcsb pdb:5L8W|reactome:R-HSA-5689880|refseq:NP_872294.2 refseq:NP_006581.2|go:"GO:0008270"(zinc ion binding)|go:"GO:0008380"(RNA splicing)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0051301"(cell division)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR028889|interpro:IPR033809|interpro:IPR038765|go:"GO:0007049"(cell cycle)|rcsb pdb:3JCR|rcsb pdb:6AH0|rcsb pdb:6QW6|rcsb pdb:6QX9|reactome:R-HSA-72163|ensembl:ENSG00000168883(gene)|ensembl:ENST00000323701(transcript)|ensembl:ENST00000409470(transcript)|go:"GO:0000245"(spliceosomal complex assembly)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0006397"(mRNA processing)|refseq:NP_001243656.1|refseq:NP_001243657.1|refseq:NP_001243654.1|refseq:NP_001243655.1|refseq:XP_006711985.1|refseq:XP_006711986.1|refseq:XP_011530789.1|refseq:XP_011530790.1|refseq:XP_016858671.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:SiueMBicjAsFl2OGlBfQ6tg1cf89606 rogid:AMLhskNenuv+zqXSa7VesSbbVK89606 intact-crc:58F10736B8C44E96|rigid:l7bhkOXQj6mPE/nmBoFlvDxGgjY false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75317 uniprotkb:Q8TBZ3 intact:EBI-2511507|ensembl:ENSP00000282344|uniprotkb:Q8TC49|uniprotkb:Q5VZV3|uniprotkb:A8K0X0 intact:EBI-2511486|ensembl:ENSP00000341037|uniprotkb:Q8WXX2|uniprotkb:Q9UF86|uniprotkb:Q8NCN7|intact:EBI-11109494|uniprotkb:H0YJJ1|uniprotkb:Q86TU2|uniprotkb:B4DN18|uniprotkb:E7EUY8|uniprotkb:F8W9S4|uniprotkb:G3V2F8|uniprotkb:G3V5R0 psi-mi:ubp12_human(display_long)|uniprotkb:USP12(gene name)|psi-mi:USP12(display_short)|uniprotkb:UBH1(gene name synonym)|uniprotkb:USP12L1(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 12(gene name synonym)|uniprotkb:Deubiquitinating enzyme 12(gene name synonym)|uniprotkb:Ubiquitin-hydrolyzing enzyme 1(gene name synonym)|uniprotkb:Ubiquitin thioesterase 12(gene name synonym) psi-mi:wdr20_human(display_long)|uniprotkb:WDR20(gene name)|psi-mi:WDR20(display_short)|uniprotkb:Protein DMR(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511514|imex:IM-12079-16 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000152484(gene)|ensembl:ENST00000282344(transcript)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0046872"(metal ion binding)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|mint:O75317|rcsb pdb:5K16|rcsb pdb:5K1A|rcsb pdb:5K1B|rcsb pdb:5K1C|rcsb pdb:5L8W|reactome:R-HSA-5689880|refseq:NP_872294.2 ensembl:ENSG00000140153(gene)|ensembl:ENST00000342702(transcript)|go:"GO:0005654"(nucleoplasm)|interpro:IPR001680(WD40 repeat)|interpro:IPR036322|mint:Q8TBZ3|rcsb pdb:5K19|rcsb pdb:5K1C|rcsb pdb:6JLQ|reactome:R-HSA-5689880|refseq:NP_001229343.1|refseq:NP_001229345.1|refseq:NP_001229346.1|refseq:NP_001229347.1|refseq:NP_653175.2|refseq:NP_851808.1|refseq:NP_851825.1|refseq:NP_001229344.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:SiueMBicjAsFl2OGlBfQ6tg1cf89606 rogid:2MfZps9YU8xQbWazkq2sIqXjHHg9606 intact-crc:58F10736B8C44E96|rigid:l7bhkOXQj6mPE/nmBoFlvDxGgjY false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75317 uniprotkb:Q96B01 intact:EBI-2511507|ensembl:ENSP00000282344|uniprotkb:Q8TC49|uniprotkb:Q5VZV3|uniprotkb:A8K0X0 intact:EBI-1178724|uniprotkb:O43403|uniprotkb:Q7Z779|uniprotkb:A8K7D3|ensembl:ENSP00000228843 psi-mi:ubp12_human(display_long)|uniprotkb:USP12(gene name)|psi-mi:USP12(display_short)|uniprotkb:UBH1(gene name synonym)|uniprotkb:USP12L1(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 12(gene name synonym)|uniprotkb:Deubiquitinating enzyme 12(gene name synonym)|uniprotkb:Ubiquitin-hydrolyzing enzyme 1(gene name synonym)|uniprotkb:Ubiquitin thioesterase 12(gene name synonym) psi-mi:r51a1_human(display_long)|uniprotkb:RAD51-interacting protein(gene name synonym)|uniprotkb:RAD51AP1(gene name)|psi-mi:RAD51AP1(display_short)|uniprotkb:PIR51(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511514|imex:IM-12079-16 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000152484(gene)|ensembl:ENST00000282344(transcript)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0046872"(metal ion binding)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|mint:O75317|rcsb pdb:5K16|rcsb pdb:5K1A|rcsb pdb:5K1B|rcsb pdb:5K1C|rcsb pdb:5L8W|reactome:R-HSA-5689880|refseq:NP_872294.2 refseq:NP_001124334.1|refseq:NP_006470.1|ensembl:ENSG00000111247(gene)|ensembl:ENST00000228843(transcript)|go:"GO:0000217"(DNA secondary structure binding)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010569"(regulation of double-strand break repair via homologous recombination)|go:"GO:0010845"(positive regulation of reciprocal meiotic recombination)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0062037"(D-loop DNA binding)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|interpro:IPR026632|interpro:IPR031419|reactome:R-HSA-5685942|reactome:R-HSA-5693554|reactome:R-HSA-5693568|reactome:R-HSA-5693579|dip:DIP-35257N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:SiueMBicjAsFl2OGlBfQ6tg1cf89606 rogid:5f/zzkdZZSmaPFxkg52s60rDnqQ9606 intact-crc:58F10736B8C44E96|rigid:l7bhkOXQj6mPE/nmBoFlvDxGgjY false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q92995 uniprotkb:Q14683 intact:EBI-714351|uniprotkb:D3DNS2|uniprotkb:Q96B25|intact:EBI-28978985|ensembl:ENSP00000263966|uniprotkb:A8K2S3|uniprotkb:B4DYF3 intact:EBI-80690|ensembl:ENSP00000323421|uniprotkb:O14995|uniprotkb:Q16351|uniprotkb:Q2M228 psi-mi:ubp13_human(display_long)|uniprotkb:Ubiquitin-specific-processing protease 13(gene name synonym)|uniprotkb:Deubiquitinating enzyme 13(gene name synonym)|uniprotkb:Isopeptidase T-3(gene name synonym)|uniprotkb:USP13(gene name)|psi-mi:USP13(display_short)|uniprotkb:ISOT3(gene name synonym)|uniprotkb:Ubiquitin thioesterase 13(gene name synonym) psi-mi:smc1a_human(display_long)|uniprotkb:SMC1A(gene name)|psi-mi:SMC1A(display_short)|uniprotkb:DXS423E(gene name synonym)|uniprotkb:KIAA0178(gene name synonym)|uniprotkb:SB1.8(gene name synonym)|uniprotkb:SMC1(gene name synonym)|uniprotkb:SMC1L1(gene name synonym)|uniprotkb:Sb1.8(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511562|imex:IM-12079-67 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003931.2|ensembl:ENSG00000058056(gene)|ensembl:ENST00000263966(transcript)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006914"(autophagy)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030318"(melanocyte differentiation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035523"(protein K29-linked deubiquitination)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0044313"(protein K6-linked deubiquitination)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0070628"(proteasome binding)|go:"GO:1904288"(BAT3 complex binding)|go:"GO:1904294"(positive regulation of ERAD pathway)|go:"GO:1904378"(maintenance of unfolded protein involved in ERAD pathway)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR009060(UBA-like)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR016652(Ubiquitinyl hydrolase)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|interpro:IPR041432|rcsb pdb:2L80|rcsb pdb:2LBC|reactome:R-HSA-5689880|reactome:R-HSA-8948751|ensembl:ENSP00000263966|ensembl:ENST00000496897|ensembl:ENSP00000417146|dip:DIP-53511N ensembl:ENSG00000072501(gene)|ensembl:ENST00000322213(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000776"(kinetochore)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0007064"(mitotic sister chromatid cohesion)|go:"GO:0008278"(cohesin complex)|go:"GO:0009314"(response to radiation)|go:"GO:0016363"(nuclear matrix)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030893"(meiotic cohesin complex)|go:"GO:0036033"(mediator complex binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051301"(cell division)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0072423"(response to DNA damage checkpoint signaling)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:0097431"(mitotic spindle pole)|interpro:IPR003395(RecF/RecN/SMC protein, N-terminal)|interpro:IPR010935(SMCs flexible hinge)|interpro:IPR024704|interpro:IPR027417|interpro:IPR028468|interpro:IPR029683|interpro:IPR036277|mint:Q14683|rcsb pdb:6WG3|rcsb pdb:6WG4|rcsb pdb:6WG6|rcsb pdb:6WGE|reactome:R-HSA-1221632|reactome:R-HSA-2467813|reactome:R-HSA-2470946|reactome:R-HSA-2500257|reactome:R-HSA-3108214|reactome:R-HSA-9018519|reactome:R-HSA-2468052|refseq:NP_006297.2|dip:DIP-30911N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:q6g2QmSYm3Xjoo+tv20s6cN8iHk9606 rogid:0UhfA7txIetlcGvSes6d+Bv1ZdY9606 intact-crc:27E0E21ACEF06F81|rigid:F+vN9l12c3ZeJdNhEcnCURMY8K8 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q92995 uniprotkb:Q9Y597 intact:EBI-714351|uniprotkb:D3DNS2|uniprotkb:Q96B25|intact:EBI-28978985|ensembl:ENSP00000263966|uniprotkb:A8K2S3|uniprotkb:B4DYF3 intact:EBI-373299|uniprotkb:A0AV15|uniprotkb:Q49AG7|uniprotkb:Q504Q9|uniprotkb:Q6PJN6|uniprotkb:Q8ND58|uniprotkb:Q8NDJ0|uniprotkb:Q8WX16|uniprotkb:D3DTA6|ensembl:ENSP00000259154 psi-mi:ubp13_human(display_long)|uniprotkb:Ubiquitin-specific-processing protease 13(gene name synonym)|uniprotkb:Deubiquitinating enzyme 13(gene name synonym)|uniprotkb:Isopeptidase T-3(gene name synonym)|uniprotkb:USP13(gene name)|psi-mi:USP13(display_short)|uniprotkb:ISOT3(gene name synonym)|uniprotkb:Ubiquitin thioesterase 13(gene name synonym) psi-mi:kctd3_human(display_long)|uniprotkb:KCTD3(gene name)|psi-mi:KCTD3(display_short)|uniprotkb:Renal carcinoma antigen NY-REN-45(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511562|imex:IM-12079-67 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003931.2|ensembl:ENSG00000058056(gene)|ensembl:ENST00000263966(transcript)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006914"(autophagy)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030318"(melanocyte differentiation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035523"(protein K29-linked deubiquitination)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0044313"(protein K6-linked deubiquitination)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0070628"(proteasome binding)|go:"GO:1904288"(BAT3 complex binding)|go:"GO:1904294"(positive regulation of ERAD pathway)|go:"GO:1904378"(maintenance of unfolded protein involved in ERAD pathway)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR009060(UBA-like)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR016652(Ubiquitinyl hydrolase)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|interpro:IPR041432|rcsb pdb:2L80|rcsb pdb:2LBC|reactome:R-HSA-5689880|reactome:R-HSA-8948751|ensembl:ENSP00000263966|ensembl:ENST00000496897|ensembl:ENSP00000417146|dip:DIP-53511N refseq:NP_057205.2|refseq:NP_001306223.1|refseq:NP_001306224.1|ensembl:ENST00000259154(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0051260"(protein homooligomerization)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR001680(WD40 repeat)|interpro:IPR003131(Potassium channel, voltage dependent, Kv, tetramerisation)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR036322|reactome:R-HSA-9013148|ensembl:ENSG00000136636(gene) psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:q6g2QmSYm3Xjoo+tv20s6cN8iHk9606 rogid:rd5uwUaxsHyv815HcLJmrI3sgNQ9606 intact-crc:27E0E21ACEF06F81|rigid:F+vN9l12c3ZeJdNhEcnCURMY8K8 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q92995 uniprotkb:Q02218 intact:EBI-714351|uniprotkb:D3DNS2|uniprotkb:Q96B25|intact:EBI-28978985|ensembl:ENSP00000263966|uniprotkb:A8K2S3|uniprotkb:B4DYF3 intact:EBI-747213|intact:EBI-1210683|uniprotkb:Q9UDX0|uniprotkb:D3DVL0|uniprotkb:B4E2U9|uniprotkb:E9PBM1|uniprotkb:Q96DD3|ensembl:ENSP00000222673 psi-mi:ubp13_human(display_long)|uniprotkb:Ubiquitin-specific-processing protease 13(gene name synonym)|uniprotkb:Deubiquitinating enzyme 13(gene name synonym)|uniprotkb:Isopeptidase T-3(gene name synonym)|uniprotkb:USP13(gene name)|psi-mi:USP13(display_short)|uniprotkb:ISOT3(gene name synonym)|uniprotkb:Ubiquitin thioesterase 13(gene name synonym) psi-mi:odo1_human(display_long)|uniprotkb:OGDH(gene name)|psi-mi:OGDH(display_short)|uniprotkb:Alpha-ketoglutarate dehydrogenase(gene name synonym)|uniprotkb:2-oxoglutarate dehydrogenase complex component E1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511562|imex:IM-12079-67 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003931.2|ensembl:ENSG00000058056(gene)|ensembl:ENST00000263966(transcript)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006914"(autophagy)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030318"(melanocyte differentiation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035523"(protein K29-linked deubiquitination)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0044313"(protein K6-linked deubiquitination)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0070628"(proteasome binding)|go:"GO:1904288"(BAT3 complex binding)|go:"GO:1904294"(positive regulation of ERAD pathway)|go:"GO:1904378"(maintenance of unfolded protein involved in ERAD pathway)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR009060(UBA-like)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR016652(Ubiquitinyl hydrolase)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|interpro:IPR041432|rcsb pdb:2L80|rcsb pdb:2LBC|reactome:R-HSA-5689880|reactome:R-HSA-8948751|ensembl:ENSP00000263966|ensembl:ENST00000496897|ensembl:ENSP00000417146|dip:DIP-53511N refseq:NP_002532.2|refseq:NP_001003941.1|refseq:NP_001158508.1|go:"GO:0021766"(hippocampus development)|go:"GO:0021794"(thalamus development)|go:"GO:0021860"(pyramidal neuron development)|go:"GO:0022028"(tangential migration from the subventricular zone to the olfactory bulb)|go:"GO:0030976"(thiamine pyrophosphate binding)|go:"GO:0021756"(striatum development)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034602"("oxoglutarate dehydrogenase (NAD+) activity")|go:"GO:0045252"(oxoglutarate dehydrogenase complex)|go:"GO:0046872"(metal ion binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0061034"(olfactory bulb mitral cell layer development)|go:"GO:0106077"(histone succinylation)|interpro:IPR001017(Dehydrogenase, E1 component)|interpro:IPR005475(Transketolase, central region)|interpro:IPR011603(2-oxoglutarate dehydrogenase, E1 component)|interpro:IPR029061|interpro:IPR031717|interpro:IPR032106|interpro:IPR042179|rcsb pdb:3ERY|reactome:R-HSA-389661|reactome:R-HSA-71064|reactome:R-HSA-71403|ensembl:ENSG00000105953(gene)|ensembl:ENST00000222673(transcript)|go:"GO:0004591"("oxoglutarate dehydrogenase (succinyl-transferring) activity")|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0006096"(glycolytic process)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006103"(2-oxoglutarate metabolic process)|go:"GO:0006104"(succinyl-CoA metabolic process)|go:"GO:0006734"(NADH metabolic process)|go:"GO:0021695"(cerebellar cortex development)|dip:DIP-39353N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:q6g2QmSYm3Xjoo+tv20s6cN8iHk9606 rogid:B9CSRCmhDYg7n5jSpuDlr2mrxDg9606 intact-crc:27E0E21ACEF06F81|rigid:F+vN9l12c3ZeJdNhEcnCURMY8K8 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q92995 uniprotkb:Q9Y4C2 intact:EBI-714351|uniprotkb:D3DNS2|uniprotkb:Q96B25|intact:EBI-28978985|ensembl:ENSP00000263966|uniprotkb:A8K2S3|uniprotkb:B4DYF3 intact:EBI-750484|uniprotkb:Q9BW63|intact:EBI-954169|uniprotkb:A8K6E0|uniprotkb:Q75KM8|uniprotkb:Q75KM9|uniprotkb:Q7L665|ensembl:ENSP00000419235 psi-mi:ubp13_human(display_long)|uniprotkb:Ubiquitin-specific-processing protease 13(gene name synonym)|uniprotkb:Deubiquitinating enzyme 13(gene name synonym)|uniprotkb:Isopeptidase T-3(gene name synonym)|uniprotkb:USP13(gene name)|psi-mi:USP13(display_short)|uniprotkb:ISOT3(gene name synonym)|uniprotkb:Ubiquitin thioesterase 13(gene name synonym) psi-mi:tcaf1_human(display_long)|uniprotkb:TCAF1(gene name)|psi-mi:TCAF1(display_short)|uniprotkb:FAM115A(gene name synonym)|uniprotkb:KIAA0738(gene name synonym)|uniprotkb:TRP channel-associated factor 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511562|imex:IM-12079-67 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003931.2|ensembl:ENSG00000058056(gene)|ensembl:ENST00000263966(transcript)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006914"(autophagy)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030318"(melanocyte differentiation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035523"(protein K29-linked deubiquitination)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0044313"(protein K6-linked deubiquitination)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0070628"(proteasome binding)|go:"GO:1904288"(BAT3 complex binding)|go:"GO:1904294"(positive regulation of ERAD pathway)|go:"GO:1904378"(maintenance of unfolded protein involved in ERAD pathway)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR009060(UBA-like)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR016652(Ubiquitinyl hydrolase)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|interpro:IPR041432|rcsb pdb:2L80|rcsb pdb:2LBC|reactome:R-HSA-5689880|reactome:R-HSA-8948751|ensembl:ENSP00000263966|ensembl:ENST00000496897|ensembl:ENSP00000417146|dip:DIP-53511N refseq:NP_001193867.1|refseq:NP_001193870.1|refseq:NP_055534.1|refseq:XP_005250131.1|refseq:XP_005250132.1|refseq:XP_005250133.1|refseq:XP_005250134.1|refseq:XP_006716254.1|refseq:XP_006716255.1|refseq:XP_016868322.1|refseq:XP_016868323.1|refseq:XP_016868324.1|refseq:XP_016868325.1|ensembl:ENSG00000198420(gene)|ensembl:ENST00000479870(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0010359"(regulation of anion channel activity)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:1901529"(positive regulation of anion channel activity)|interpro:IPR029062|interpro:IPR031161|interpro:IPR035423|interpro:IPR042279 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:q6g2QmSYm3Xjoo+tv20s6cN8iHk9606 rogid:krj5GKiU60IW49DV76f4FWG3RHE9606 intact-crc:27E0E21ACEF06F81|rigid:F+vN9l12c3ZeJdNhEcnCURMY8K8 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q92995 uniprotkb:P46379 intact:EBI-714351|uniprotkb:D3DNS2|uniprotkb:Q96B25|intact:EBI-28978985|ensembl:ENSP00000263966|uniprotkb:A8K2S3|uniprotkb:B4DYF3 intact:EBI-347552|uniprotkb:A2ADJ7|uniprotkb:A3KQ42|uniprotkb:A3KQ44|uniprotkb:A6NGY6|uniprotkb:A6PWF7|uniprotkb:O95874|uniprotkb:Q5HYL9|uniprotkb:Q5SQ35|uniprotkb:Q5SQ36|uniprotkb:Q5SQ37|uniprotkb:Q5SQ41|uniprotkb:Q5SRP8|uniprotkb:Q5SRP9|uniprotkb:Q5STC1|uniprotkb:Q5STX1|uniprotkb:Q5STX3|uniprotkb:Q96SA6|uniprotkb:Q9BCN4|uniprotkb:B0UX84|uniprotkb:B4DZ12|uniprotkb:B4E3V4|uniprotkb:E7EMZ4|uniprotkb:F8VXY4|ensembl:ENSP00000354368|ensembl:ENSP00000390966|ensembl:ENSP00000397894 psi-mi:ubp13_human(display_long)|uniprotkb:Ubiquitin-specific-processing protease 13(gene name synonym)|uniprotkb:Deubiquitinating enzyme 13(gene name synonym)|uniprotkb:Isopeptidase T-3(gene name synonym)|uniprotkb:USP13(gene name)|psi-mi:USP13(display_short)|uniprotkb:ISOT3(gene name synonym)|uniprotkb:Ubiquitin thioesterase 13(gene name synonym) psi-mi:bag6_human(display_long)|uniprotkb:BAT3(gene name synonym)|uniprotkb:G3(gene name synonym)|uniprotkb:HLA-B-associated transcript 3(gene name synonym)|uniprotkb:Protein G3(gene name synonym)|uniprotkb:BCL2-associated athanogene 6(gene name synonym)|uniprotkb:BAG6(gene name)|psi-mi:BAG6(display_short)|uniprotkb:BAG family molecular chaperone regulator 6(gene name synonym)|uniprotkb:Protein Scythe(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511562|imex:IM-12079-67 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003931.2|ensembl:ENSG00000058056(gene)|ensembl:ENST00000263966(transcript)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006914"(autophagy)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030318"(melanocyte differentiation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035523"(protein K29-linked deubiquitination)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0044313"(protein K6-linked deubiquitination)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0070628"(proteasome binding)|go:"GO:1904288"(BAT3 complex binding)|go:"GO:1904294"(positive regulation of ERAD pathway)|go:"GO:1904378"(maintenance of unfolded protein involved in ERAD pathway)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR009060(UBA-like)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR016652(Ubiquitinyl hydrolase)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|interpro:IPR041432|rcsb pdb:2L80|rcsb pdb:2LBC|reactome:R-HSA-5689880|reactome:R-HSA-8948751|ensembl:ENSP00000263966|ensembl:ENST00000496897|ensembl:ENSP00000417146|dip:DIP-53511N dip:DIP-31191N|refseq:NP_001092004.1|refseq:NP_001186627.1|refseq:NP_004630.3|refseq:NP_542433.1|refseq:NP_542434.1|refseq:NP_001186626.1|refseq:XP_016866776.1|ensembl:ENSG00000096155(gene)|ensembl:ENSG00000229524(gene)|ensembl:ENSG00000233348(gene)|ensembl:ENST00000361076(transcript)|ensembl:ENST00000449450(transcript)|ensembl:ENST00000451932(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0002429"(immune response-activating cell surface receptor signaling pathway)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007130"(synaptonemal complex assembly)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0016020"(membrane)|go:"GO:0018393"(internal peptidyl-lysine acetylation)|go:"GO:0030101"(natural killer cell activation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030324"(lung development)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0043022"(ribosome binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0050821"(protein stabilization)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0061857"(endoplasmic reticulum stress-induced pre-emptive quality control)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070628"(proteasome binding)|go:"GO:0071712"(ER-associated misfolded protein catabolic process)|go:"GO:0071816"(tail-anchored membrane protein insertion into ER membrane)|go:"GO:0071818"(BAT3 complex)|go:"GO:1904294"(positive regulation of ERAD pathway)|go:"GO:1904378"(maintenance of unfolded protein involved in ERAD pathway)|go:"GO:1904379"(protein localization to cytosolic proteasome complex involved in ERAD pathway)|go:"GO:1990381"(ubiquitin-specific protease binding)|interpro:IPR000626(Ubiquitin)|interpro:IPR019954|interpro:IPR021925|interpro:IPR029071|mint:P46379|rcsb pdb:1WX9|rcsb pdb:2N9P|rcsb pdb:4DWF|rcsb pdb:4EEW|rcsb pdb:4WWR|rcsb pdb:6AU8|reactome:R-HSA-9609523|rcsb pdb:4X86 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:q6g2QmSYm3Xjoo+tv20s6cN8iHk9606 rogid:ghHlLBbS3yeP2mN6AOoHs+CECKU9606 intact-crc:27E0E21ACEF06F81|rigid:F+vN9l12c3ZeJdNhEcnCURMY8K8 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q92995 uniprotkb:Q9H3F6 intact:EBI-714351|uniprotkb:D3DNS2|uniprotkb:Q96B25|intact:EBI-28978985|ensembl:ENSP00000263966|uniprotkb:A8K2S3|uniprotkb:B4DYF3 intact:EBI-2505886|uniprotkb:Q53HN2|uniprotkb:Q59FV1|uniprotkb:Q6PL47|uniprotkb:Q96SU0|intact:EBI-2563423|ensembl:ENSP00000228495 psi-mi:ubp13_human(display_long)|uniprotkb:Ubiquitin-specific-processing protease 13(gene name synonym)|uniprotkb:Deubiquitinating enzyme 13(gene name synonym)|uniprotkb:Isopeptidase T-3(gene name synonym)|uniprotkb:USP13(gene name)|psi-mi:USP13(display_short)|uniprotkb:ISOT3(gene name synonym)|uniprotkb:Ubiquitin thioesterase 13(gene name synonym) psi-mi:bacd3_human(display_long)|uniprotkb:BTB/POZ domain-containing protein KCTD10(gene name synonym)|uniprotkb:Potassium channel tetramerization domain-containing protein 10(gene name synonym)|uniprotkb:KCTD10(gene name)|psi-mi:KCTD10(display_short)|uniprotkb:ULR061(gene name synonym)|uniprotkb:MSTP028(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511562|imex:IM-12079-67 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003931.2|ensembl:ENSG00000058056(gene)|ensembl:ENST00000263966(transcript)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006914"(autophagy)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030318"(melanocyte differentiation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035523"(protein K29-linked deubiquitination)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0044313"(protein K6-linked deubiquitination)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0070628"(proteasome binding)|go:"GO:1904288"(BAT3 complex binding)|go:"GO:1904294"(positive regulation of ERAD pathway)|go:"GO:1904378"(maintenance of unfolded protein involved in ERAD pathway)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR009060(UBA-like)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR016652(Ubiquitinyl hydrolase)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|interpro:IPR041432|rcsb pdb:2L80|rcsb pdb:2LBC|reactome:R-HSA-5689880|reactome:R-HSA-8948751|ensembl:ENSP00000263966|ensembl:ENST00000496897|ensembl:ENSP00000417146|dip:DIP-53511N refseq:NP_001304324.1|refseq:NP_001304328.1|refseq:NP_114160.1|ensembl:ENSG00000110906(gene)|ensembl:ENST00000228495(transcript)|go:"GO:0005112"(Notch binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0051260"(protein homooligomerization)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR003131(Potassium channel, voltage dependent, Kv, tetramerisation)|interpro:IPR011333(BTB/POZ fold)|rcsb pdb:5FTA psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:q6g2QmSYm3Xjoo+tv20s6cN8iHk9606 rogid:ol+Pl17F/3aoKl1CD+edgT9KweI9606 intact-crc:27E0E21ACEF06F81|rigid:F+vN9l12c3ZeJdNhEcnCURMY8K8 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q92995 uniprotkb:Q96CS3 intact:EBI-714351|uniprotkb:D3DNS2|uniprotkb:Q96B25|intact:EBI-28978985|ensembl:ENSP00000263966|uniprotkb:A8K2S3|uniprotkb:B4DYF3 intact:EBI-1055805|uniprotkb:O94963|uniprotkb:Q8IUF2|uniprotkb:Q9BRP2|uniprotkb:Q9BVM7|ensembl:ENSP00000261942 psi-mi:ubp13_human(display_long)|uniprotkb:Ubiquitin-specific-processing protease 13(gene name synonym)|uniprotkb:Deubiquitinating enzyme 13(gene name synonym)|uniprotkb:Isopeptidase T-3(gene name synonym)|uniprotkb:USP13(gene name)|psi-mi:USP13(display_short)|uniprotkb:ISOT3(gene name synonym)|uniprotkb:Ubiquitin thioesterase 13(gene name synonym) psi-mi:faf2_human(display_long)|uniprotkb:Protein ETEA(gene name synonym)|uniprotkb:FAF2(gene name)|psi-mi:FAF2(display_short)|uniprotkb:ETEA(gene name synonym)|uniprotkb:KIAA0887(gene name synonym)|uniprotkb:UBXD8(gene name synonym)|uniprotkb:UBXN3B(gene name synonym)|uniprotkb:UBX domain-containing protein 3B(gene name synonym)|uniprotkb:UBX domain-containing protein 8(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511562|imex:IM-12079-67 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003931.2|ensembl:ENSG00000058056(gene)|ensembl:ENST00000263966(transcript)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006914"(autophagy)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030318"(melanocyte differentiation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035523"(protein K29-linked deubiquitination)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0044313"(protein K6-linked deubiquitination)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0070628"(proteasome binding)|go:"GO:1904288"(BAT3 complex binding)|go:"GO:1904294"(positive regulation of ERAD pathway)|go:"GO:1904378"(maintenance of unfolded protein involved in ERAD pathway)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR009060(UBA-like)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR016652(Ubiquitinyl hydrolase)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|interpro:IPR041432|rcsb pdb:2L80|rcsb pdb:2LBC|reactome:R-HSA-5689880|reactome:R-HSA-8948751|ensembl:ENSP00000263966|ensembl:ENST00000496897|ensembl:ENSP00000417146|dip:DIP-53511N refseq:NP_055428.1|ensembl:ENSP00000261942|ensembl:ENST00000261942(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005811"(lipid droplet)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034098"(VCP-NPL4-UFD1 AAA ATPase complex)|go:"GO:0034389"(lipid droplet organization)|go:"GO:0035473"(lipase binding)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0055102"(lipase inhibitor activity)|interpro:IPR001012(UBX)|interpro:IPR006577(UAS)|interpro:IPR009060(UBA-like)|interpro:IPR029071|interpro:IPR036249|mint:Q96CS3|rcsb pdb:2DAM|reactome:R-HSA-6798695|reactome:R-HSA-8980692|ensembl:ENSG00000113194(gene)|dip:DIP-46261N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:q6g2QmSYm3Xjoo+tv20s6cN8iHk9606 rogid:GCm7BqDpwxDW1iABu0cShmWHtZQ9606 intact-crc:27E0E21ACEF06F81|rigid:F+vN9l12c3ZeJdNhEcnCURMY8K8 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q92995 uniprotkb:Q9UQE7 intact:EBI-714351|uniprotkb:D3DNS2|uniprotkb:Q96B25|intact:EBI-28978985|ensembl:ENSP00000263966|uniprotkb:A8K2S3|uniprotkb:B4DYF3 intact:EBI-80718|ensembl:ENSP00000354720|uniprotkb:O60464|uniprotkb:Q5T482|uniprotkb:A8K156 psi-mi:ubp13_human(display_long)|uniprotkb:Ubiquitin-specific-processing protease 13(gene name synonym)|uniprotkb:Deubiquitinating enzyme 13(gene name synonym)|uniprotkb:Isopeptidase T-3(gene name synonym)|uniprotkb:USP13(gene name)|psi-mi:USP13(display_short)|uniprotkb:ISOT3(gene name synonym)|uniprotkb:Ubiquitin thioesterase 13(gene name synonym) psi-mi:smc3_human(display_long)|uniprotkb:SMC3(gene name)|psi-mi:SMC3(display_short)|uniprotkb:BAM(gene name synonym)|uniprotkb:SMC3L1(gene name synonym)|uniprotkb:Chondroitin sulfate proteoglycan 6(gene name synonym)|uniprotkb:Chromosome-associated polypeptide(gene name synonym)|uniprotkb:Basement membrane-associated chondroitin proteoglycan(gene name synonym)|uniprotkb:BMH(gene name synonym)|uniprotkb:CSPG6(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511562|imex:IM-12079-67 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003931.2|ensembl:ENSG00000058056(gene)|ensembl:ENST00000263966(transcript)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006914"(autophagy)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030318"(melanocyte differentiation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035523"(protein K29-linked deubiquitination)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0044313"(protein K6-linked deubiquitination)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0070628"(proteasome binding)|go:"GO:1904288"(BAT3 complex binding)|go:"GO:1904294"(positive regulation of ERAD pathway)|go:"GO:1904378"(maintenance of unfolded protein involved in ERAD pathway)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR009060(UBA-like)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR016652(Ubiquitinyl hydrolase)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|interpro:IPR041432|rcsb pdb:2L80|rcsb pdb:2LBC|reactome:R-HSA-5689880|reactome:R-HSA-8948751|ensembl:ENSP00000263966|ensembl:ENST00000496897|ensembl:ENSP00000417146|dip:DIP-53511N go:"GO:0090307"(mitotic spindle assembly)|go:"GO:0097431"(mitotic spindle pole)|interpro:IPR003395(RecF/RecN/SMC protein, N-terminal)|interpro:IPR010935(SMCs flexible hinge)|interpro:IPR024704|interpro:IPR027417|interpro:IPR036277|interpro:IPR041741|mint:Q9UQE7|rcsb pdb:6WG3|rcsb pdb:6WG4|rcsb pdb:6WG6|rcsb pdb:6WGE|reactome:R-HSA-1221632|reactome:R-HSA-2467813|reactome:R-HSA-2468052|reactome:R-HSA-2470946|reactome:R-HSA-2500257|reactome:R-HSA-3108214|reactome:R-HSA-9018519|go:"GO:0070840"(dynein complex binding)|ensembl:ENSG00000108055(gene)|ensembl:ENST00000361804(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000785"(chromatin)|go:"GO:0000800"(lateral element)|go:"GO:0003682"(chromatin binding)|go:"GO:0003777"(microtubule motor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0008278"(cohesin complex)|go:"GO:0016363"(nuclear matrix)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030893"(meiotic cohesin complex)|go:"GO:0034991"(nuclear meiotic cohesin complex)|go:"GO:0036033"(mediator complex binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0051301"(cell division)|go:"GO:0051321"(meiotic cell cycle)|refseq:NP_005436.1|dip:DIP-29200N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:q6g2QmSYm3Xjoo+tv20s6cN8iHk9606 rogid:pUxr+sTtttRzGlqCRz/25woNtrg9606 intact-crc:27E0E21ACEF06F81|rigid:F+vN9l12c3ZeJdNhEcnCURMY8K8 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q92995 uniprotkb:Q96J02 intact:EBI-714351|uniprotkb:D3DNS2|uniprotkb:Q96B25|intact:EBI-28978985|ensembl:ENSP00000263966|uniprotkb:A8K2S3|uniprotkb:B4DYF3 intact:EBI-1564678|uniprotkb:O43584|uniprotkb:Q5TEL0|uniprotkb:Q96F66|uniprotkb:Q9BY75|uniprotkb:Q9H451|uniprotkb:Q9H4U5|uniprotkb:A6NEW4|uniprotkb:Q5QP37|uniprotkb:E1P5P3|uniprotkb:B4E234|uniprotkb:F5H217|ensembl:ENSP00000262650|ensembl:ENSP00000499786 psi-mi:ubp13_human(display_long)|uniprotkb:Ubiquitin-specific-processing protease 13(gene name synonym)|uniprotkb:Deubiquitinating enzyme 13(gene name synonym)|uniprotkb:Isopeptidase T-3(gene name synonym)|uniprotkb:USP13(gene name)|psi-mi:USP13(display_short)|uniprotkb:ISOT3(gene name synonym)|uniprotkb:Ubiquitin thioesterase 13(gene name synonym) psi-mi:itch_human(display_long)|uniprotkb:HECT-type E3 ubiquitin transferase Itchy homolog(gene name synonym)|uniprotkb:Atrophin-1-interacting protein 4(gene name synonym)|uniprotkb:NFE2-associated polypeptide 1(gene name synonym)|uniprotkb:ITCH(gene name)|psi-mi:ITCH(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511562|imex:IM-12079-67 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003931.2|ensembl:ENSG00000058056(gene)|ensembl:ENST00000263966(transcript)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006914"(autophagy)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030318"(melanocyte differentiation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035523"(protein K29-linked deubiquitination)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0044313"(protein K6-linked deubiquitination)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0070628"(proteasome binding)|go:"GO:1904288"(BAT3 complex binding)|go:"GO:1904294"(positive regulation of ERAD pathway)|go:"GO:1904378"(maintenance of unfolded protein involved in ERAD pathway)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR009060(UBA-like)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR016652(Ubiquitinyl hydrolase)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|interpro:IPR041432|rcsb pdb:2L80|rcsb pdb:2LBC|reactome:R-HSA-5689880|reactome:R-HSA-8948751|ensembl:ENSP00000263966|ensembl:ENST00000496897|ensembl:ENSP00000417146|dip:DIP-53511N refseq:NP_001311126.1|refseq:NP_113671.3|refseq:NP_001244066.1|refseq:NP_001311127.1|refseq:NP_001244067.1|refseq:XP_016883578.1|refseq:XP_016883580.1|dip:DIP-29849N|ensembl:ENSG00000078747(gene)|ensembl:ENST00000262650(transcript)|ensembl:ENST00000665346(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0002669"(positive regulation of T cell anergy)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016874"(ligase activity)|go:"GO:0019787"(ubiquitin-like protein transferase activity)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032480"(negative regulation of type I interferon production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035519"(protein K29-linked ubiquitination)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045236"(CXCR chemokine receptor binding)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0046642"(negative regulation of alpha-beta T cell proliferation)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0050687"(negative regulation of defense response to virus)|go:"GO:0051607"(defense response to virus)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070423"(nucleotide-binding oligomerization domain containing signaling pathway)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0090085"(regulation of protein deubiquitination)|go:"GO:1902036"(regulation of hematopoietic stem cell differentiation)|go:"GO:1990763"(arrestin family protein binding)|go:"GO:2000646"(positive regulation of receptor catabolic process)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|mint:Q96J02|rcsb pdb:2DMV|rcsb pdb:2KYK|rcsb pdb:2NQ3|rcsb pdb:2P4R|rcsb pdb:2YSF|rcsb pdb:3TUG|rcsb pdb:4ROF|rcsb pdb:5C7M|rcsb pdb:5CQ2|rcsb pdb:5DWS|rcsb pdb:5DZD|rcsb pdb:5SXP|reactome:R-HSA-1253288|reactome:R-HSA-168638|reactome:R-HSA-2122948|reactome:R-HSA-5610780|reactome:R-HSA-5632684|reactome:R-HSA-8939236|reactome:R-HSA-936440|reactome:R-HSA-983168 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:q6g2QmSYm3Xjoo+tv20s6cN8iHk9606 rogid:JyySOfI+ZHOI1mvdxWDGN6njgCY9606 intact-crc:27E0E21ACEF06F81|rigid:F+vN9l12c3ZeJdNhEcnCURMY8K8 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q92995 uniprotkb:Q15843 intact:EBI-714351|uniprotkb:D3DNS2|uniprotkb:Q96B25|intact:EBI-28978985|ensembl:ENSP00000263966|uniprotkb:A8K2S3|uniprotkb:B4DYF3 intact:EBI-716247|uniprotkb:Q3SXN8|uniprotkb:Q6LES6|ensembl:ENSP00000250495|ensembl:ENSP00000496420 psi-mi:ubp13_human(display_long)|uniprotkb:Ubiquitin-specific-processing protease 13(gene name synonym)|uniprotkb:Deubiquitinating enzyme 13(gene name synonym)|uniprotkb:Isopeptidase T-3(gene name synonym)|uniprotkb:USP13(gene name)|psi-mi:USP13(display_short)|uniprotkb:ISOT3(gene name synonym)|uniprotkb:Ubiquitin thioesterase 13(gene name synonym) psi-mi:nedd8_human(display_long)|uniprotkb:Ubiquitin-like protein Nedd8(gene name synonym)|uniprotkb:Neddylin(gene name synonym)|uniprotkb:Neural precursor cell expressed developmentally down-regulated protein 8(gene name synonym)|uniprotkb:NEDD8(gene name)|psi-mi:NEDD8(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511562|imex:IM-12079-67 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003931.2|ensembl:ENSG00000058056(gene)|ensembl:ENST00000263966(transcript)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006914"(autophagy)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030318"(melanocyte differentiation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035523"(protein K29-linked deubiquitination)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0044313"(protein K6-linked deubiquitination)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0070628"(proteasome binding)|go:"GO:1904288"(BAT3 complex binding)|go:"GO:1904294"(positive regulation of ERAD pathway)|go:"GO:1904378"(maintenance of unfolded protein involved in ERAD pathway)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR009060(UBA-like)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR016652(Ubiquitinyl hydrolase)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|interpro:IPR041432|rcsb pdb:2L80|rcsb pdb:2LBC|reactome:R-HSA-5689880|reactome:R-HSA-8948751|ensembl:ENSP00000263966|ensembl:ENST00000496897|ensembl:ENSP00000417146|dip:DIP-53511N refseq:NP_006147.1|ensembl:ENSG00000129559(gene)|ensembl:ENSG00000285246(gene)|ensembl:ENST00000250495(transcript)|ensembl:ENST00000643069(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006508"(proteolysis)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008104"(protein localization)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0019941"(modification-dependent protein catabolic process)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0031386"(protein tag)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0045116"(protein neddylation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000626(Ubiquitin)|interpro:IPR019954|interpro:IPR019956|interpro:IPR029071|interpro:IPR038738|mint:Q15843|rcsb pdb:1NDD|rcsb pdb:1R4M|rcsb pdb:1R4N|rcsb pdb:1XT9|rcsb pdb:2BKR|rcsb pdb:2KO3|rcsb pdb:2N7K|rcsb pdb:2NVU|rcsb pdb:3DBH|rcsb pdb:3DBL|rcsb pdb:3DBR|rcsb pdb:3DQV|rcsb pdb:3GZN|rcsb pdb:4F8C|rcsb pdb:4FBJ|rcsb pdb:4HCP|rcsb pdb:4P5O|rcsb pdb:6R7F|rcsb pdb:6R7I|rcsb pdb:6TTU|rcsb pdb:7B5L|rcsb pdb:7B5N|reactome:R-HSA-2173789|reactome:R-HSA-5689603|reactome:R-HSA-8856825|reactome:R-HSA-8951664|reactome:R-HSA-917937|dip:DIP-29266N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:q6g2QmSYm3Xjoo+tv20s6cN8iHk9606 rogid:qB1KNoIOwa1ONfphWDWjJri9hwE9606 intact-crc:27E0E21ACEF06F81|rigid:F+vN9l12c3ZeJdNhEcnCURMY8K8 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q92995 uniprotkb:Q8TAT6 intact:EBI-714351|uniprotkb:D3DNS2|uniprotkb:Q96B25|intact:EBI-28978985|ensembl:ENSP00000263966|uniprotkb:A8K2S3|uniprotkb:B4DYF3 intact:EBI-1994109|uniprotkb:Q8N3J1|uniprotkb:Q9H8V2|uniprotkb:Q9H964|uniprotkb:Q9NWR5|uniprotkb:Q9P229|ensembl:ENSP00000331487 psi-mi:ubp13_human(display_long)|uniprotkb:Ubiquitin-specific-processing protease 13(gene name synonym)|uniprotkb:Deubiquitinating enzyme 13(gene name synonym)|uniprotkb:Isopeptidase T-3(gene name synonym)|uniprotkb:USP13(gene name)|psi-mi:USP13(display_short)|uniprotkb:ISOT3(gene name synonym)|uniprotkb:Ubiquitin thioesterase 13(gene name synonym) psi-mi:npl4_human(display_long)|uniprotkb:NPLOC4(gene name)|psi-mi:NPLOC4(display_short)|uniprotkb:KIAA1499(gene name synonym)|uniprotkb:NPL4(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511562|imex:IM-12079-67 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003931.2|ensembl:ENSG00000058056(gene)|ensembl:ENST00000263966(transcript)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006914"(autophagy)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030318"(melanocyte differentiation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035523"(protein K29-linked deubiquitination)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0044313"(protein K6-linked deubiquitination)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0070628"(proteasome binding)|go:"GO:1904288"(BAT3 complex binding)|go:"GO:1904294"(positive regulation of ERAD pathway)|go:"GO:1904378"(maintenance of unfolded protein involved in ERAD pathway)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR009060(UBA-like)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR016652(Ubiquitinyl hydrolase)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|interpro:IPR041432|rcsb pdb:2L80|rcsb pdb:2LBC|reactome:R-HSA-5689880|reactome:R-HSA-8948751|ensembl:ENSP00000263966|ensembl:ENST00000496897|ensembl:ENSP00000417146|dip:DIP-53511N refseq:XP_011523281.1|refseq:NP_060391.2|dip:DIP-44059N|ensembl:ENSG00000182446(gene)|ensembl:ENST00000331134(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007030"(Golgi organization)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032480"(negative regulation of type I interferon production)|go:"GO:0034098"(VCP-NPL4-UFD1 AAA ATPase complex)|go:"GO:0036501"(UFD1-NPL4 complex)|go:"GO:0039536"(negative regulation of RIG-I signaling pathway)|go:"GO:0042175"(nuclear outer membrane-endoplasmic reticulum membrane network)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR007716(NPL4, zinc-binding putative)|interpro:IPR007717(NPL4)|interpro:IPR016563(Polyubiquitin-tagged protein recognition complex, Npl4 component)|interpro:IPR024682|interpro:IPR029071|interpro:IPR036443|interpro:IPR037518|mint:Q8TAT6|reactome:R-HSA-110320 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:q6g2QmSYm3Xjoo+tv20s6cN8iHk9606 rogid:GXRNmG7yqEf5aFMo7yPDih93yfk9606 intact-crc:27E0E21ACEF06F81|rigid:F+vN9l12c3ZeJdNhEcnCURMY8K8 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q92995 uniprotkb:Q92890 intact:EBI-714351|uniprotkb:D3DNS2|uniprotkb:Q96B25|intact:EBI-28978985|ensembl:ENSP00000263966|uniprotkb:A8K2S3|uniprotkb:B4DYF3 intact:EBI-1994090|uniprotkb:Q9Y5N0|uniprotkb:A8MW31|ensembl:ENSP00000263202 psi-mi:ubp13_human(display_long)|uniprotkb:Ubiquitin-specific-processing protease 13(gene name synonym)|uniprotkb:Deubiquitinating enzyme 13(gene name synonym)|uniprotkb:Isopeptidase T-3(gene name synonym)|uniprotkb:USP13(gene name)|psi-mi:USP13(display_short)|uniprotkb:ISOT3(gene name synonym)|uniprotkb:Ubiquitin thioesterase 13(gene name synonym) psi-mi:ufd1_human(display_long)|uniprotkb:UFD1(gene name)|psi-mi:UFD1(display_short)|uniprotkb:UFD1L(gene name synonym)|uniprotkb:Ubiquitin fusion degradation protein 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511562|imex:IM-12079-67 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003931.2|ensembl:ENSG00000058056(gene)|ensembl:ENST00000263966(transcript)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006914"(autophagy)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030318"(melanocyte differentiation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035523"(protein K29-linked deubiquitination)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0044313"(protein K6-linked deubiquitination)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0070628"(proteasome binding)|go:"GO:1904288"(BAT3 complex binding)|go:"GO:1904294"(positive regulation of ERAD pathway)|go:"GO:1904378"(maintenance of unfolded protein involved in ERAD pathway)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR009060(UBA-like)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR016652(Ubiquitinyl hydrolase)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|interpro:IPR041432|rcsb pdb:2L80|rcsb pdb:2LBC|reactome:R-HSA-5689880|reactome:R-HSA-8948751|ensembl:ENSP00000263966|ensembl:ENST00000496897|ensembl:ENSP00000417146|dip:DIP-53511N refseq:NP_005650.2|refseq:NP_001030324.2|dip:DIP-45954N|ensembl:ENSG00000070010(gene)|ensembl:ENST00000263202(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0032480"(negative regulation of type I interferon production)|go:"GO:0034098"(VCP-NPL4-UFD1 AAA ATPase complex)|go:"GO:0036435"(K48-linked polyubiquitin modification-dependent protein binding)|go:"GO:0036501"(UFD1-NPL4 complex)|go:"GO:0039536"(negative regulation of RIG-I signaling pathway)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0071712"(ER-associated misfolded protein catabolic process)|interpro:IPR004854(Ubiquitin fusion degradation protein UFD1)|interpro:IPR042299|mint:Q92890|rcsb pdb:2YUJ|rcsb pdb:5B6C|rcsb pdb:5C1B|reactome:R-HSA-110320|reactome:R-HSA-5689880|go:"GO:0031593"(polyubiquitin modification-dependent protein binding) psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:q6g2QmSYm3Xjoo+tv20s6cN8iHk9606 rogid:TD7xj2n1cP5JexKMoVg1JfTQArI9606 intact-crc:27E0E21ACEF06F81|rigid:F+vN9l12c3ZeJdNhEcnCURMY8K8 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q92995 uniprotkb:P11441 intact:EBI-714351|uniprotkb:D3DNS2|uniprotkb:Q96B25|intact:EBI-28978985|ensembl:ENSP00000263966|uniprotkb:A8K2S3|uniprotkb:B4DYF3 intact:EBI-356983|uniprotkb:Q5HY80|ensembl:ENSP00000358674 psi-mi:ubp13_human(display_long)|uniprotkb:Ubiquitin-specific-processing protease 13(gene name synonym)|uniprotkb:Deubiquitinating enzyme 13(gene name synonym)|uniprotkb:Isopeptidase T-3(gene name synonym)|uniprotkb:USP13(gene name)|psi-mi:USP13(display_short)|uniprotkb:ISOT3(gene name synonym)|uniprotkb:Ubiquitin thioesterase 13(gene name synonym) psi-mi:ubl4a_human(display_long)|uniprotkb:UBL4A(gene name)|psi-mi:UBL4A(display_short)|uniprotkb:GDX(gene name synonym)|uniprotkb:DXS254E(gene name synonym)|uniprotkb:UBL4(gene name synonym)|uniprotkb:Ubiquitin-like protein GDX(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511562|imex:IM-12079-67 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003931.2|ensembl:ENSG00000058056(gene)|ensembl:ENST00000263966(transcript)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006914"(autophagy)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030318"(melanocyte differentiation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035523"(protein K29-linked deubiquitination)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0044313"(protein K6-linked deubiquitination)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0070628"(proteasome binding)|go:"GO:1904288"(BAT3 complex binding)|go:"GO:1904294"(positive regulation of ERAD pathway)|go:"GO:1904378"(maintenance of unfolded protein involved in ERAD pathway)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR009060(UBA-like)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR016652(Ubiquitinyl hydrolase)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|interpro:IPR041432|rcsb pdb:2L80|rcsb pdb:2LBC|reactome:R-HSA-5689880|reactome:R-HSA-8948751|ensembl:ENSP00000263966|ensembl:ENST00000496897|ensembl:ENSP00000417146|dip:DIP-53511N refseq:NP_055050.1|ensembl:ENSG00000102178(gene)|ensembl:ENST00000369660(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0016020"(membrane)|go:"GO:0019787"(ubiquitin-like protein transferase activity)|go:"GO:0051087"(chaperone binding)|go:"GO:0071816"(tail-anchored membrane protein insertion into ER membrane)|go:"GO:0071818"(BAT3 complex)|interpro:IPR000626(Ubiquitin)|interpro:IPR019954|interpro:IPR019956|interpro:IPR029071|interpro:IPR041421|interpro:IPR044724|mint:P11441|rcsb pdb:2DZI|rcsb pdb:4WWR|rcsb pdb:4X86|reactome:R-HSA-9609523 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:q6g2QmSYm3Xjoo+tv20s6cN8iHk9606 rogid:euKOrDRC1mx0s2QVY95010PRaIg9606 intact-crc:27E0E21ACEF06F81|rigid:F+vN9l12c3ZeJdNhEcnCURMY8K8 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q92995 uniprotkb:Q9NQC7 intact:EBI-714351|uniprotkb:D3DNS2|uniprotkb:Q96B25|intact:EBI-28978985|ensembl:ENSP00000263966|uniprotkb:A8K2S3|uniprotkb:B4DYF3 intact:EBI-2117940|uniprotkb:O94934|uniprotkb:Q7L3N6|uniprotkb:Q96EH0|uniprotkb:Q9NZX9|ensembl:ENSP00000308928|ensembl:ENSP00000392025 psi-mi:ubp13_human(display_long)|uniprotkb:Ubiquitin-specific-processing protease 13(gene name synonym)|uniprotkb:Deubiquitinating enzyme 13(gene name synonym)|uniprotkb:Isopeptidase T-3(gene name synonym)|uniprotkb:USP13(gene name)|psi-mi:USP13(display_short)|uniprotkb:ISOT3(gene name synonym)|uniprotkb:Ubiquitin thioesterase 13(gene name synonym) psi-mi:cyld_human(display_long)|uniprotkb:Ubiquitin thioesterase CYLD(gene name synonym)|uniprotkb:CYLD(gene name)|psi-mi:CYLD(display_short)|uniprotkb:CYLD1(gene name synonym)|uniprotkb:KIAA0849(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease CYLD(gene name synonym)|uniprotkb:Deubiquitinating enzyme CYLD(gene name synonym)|uniprotkb:HSPC057(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511562|imex:IM-12079-67 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003931.2|ensembl:ENSG00000058056(gene)|ensembl:ENST00000263966(transcript)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006914"(autophagy)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030318"(melanocyte differentiation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035523"(protein K29-linked deubiquitination)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0044313"(protein K6-linked deubiquitination)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0070628"(proteasome binding)|go:"GO:1904288"(BAT3 complex binding)|go:"GO:1904294"(positive regulation of ERAD pathway)|go:"GO:1904378"(maintenance of unfolded protein involved in ERAD pathway)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR009060(UBA-like)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR016652(Ubiquitinyl hydrolase)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|interpro:IPR041432|rcsb pdb:2L80|rcsb pdb:2LBC|reactome:R-HSA-5689880|reactome:R-HSA-8948751|ensembl:ENSP00000263966|ensembl:ENST00000496897|ensembl:ENSP00000417146|dip:DIP-53511N refseq:NP_001035814.1|refseq:NP_001035877.1|refseq:NP_056062.1|refseq:XP_016878467.1|refseq:XP_016878469.1|go:"GO:0007049"(cell cycle)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010803"(regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0005874"(microtubule)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032480"(negative regulation of type I interferon production)|go:"GO:0036064"(ciliary basal body)|go:"GO:0045087"(innate immune response)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0060544"(regulation of necroptotic process)|go:"GO:0061578"(Lys63-specific deubiquitinase activity)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0070266"(necroptotic process)|go:"GO:0070423"(nucleotide-binding oligomerization domain containing signaling pathway)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097542"(ciliary tip)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1902017"(regulation of cilium assembly)|go:"GO:1903753"(negative regulation of p38MAPK cascade)|go:"GO:1990108"(protein linear deubiquitination)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001242"(regulation of intrinsic apoptotic signaling pathway)|interpro:IPR000938(Cytoskeleton-associated protein, CAP-Gly)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR036859|interpro:IPR038765|mint:Q9NQC7|rcsb pdb:1IXD|rcsb pdb:1WHL|rcsb pdb:1WHM|rcsb pdb:2VHF|reactome:R-HSA-168638|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5689880|reactome:R-HSA-936440|ensembl:ENSG00000083799(gene)|ensembl:ENST00000311559(transcript)|ensembl:ENST00000427738(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|refseq:XP_005255869.1|refseq:XP_006721212.1|refseq:XP_011521209.1|refseq:XP_016878466.1|refseq:XP_016878468.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:q6g2QmSYm3Xjoo+tv20s6cN8iHk9606 rogid:Z01woAwtDVaoNnAthw9tTrBqRao9606 intact-crc:27E0E21ACEF06F81|rigid:F+vN9l12c3ZeJdNhEcnCURMY8K8 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q92995 uniprotkb:Q9NR28 intact:EBI-714351|uniprotkb:D3DNS2|uniprotkb:Q96B25|intact:EBI-28978985|ensembl:ENSP00000263966|uniprotkb:A8K2S3|uniprotkb:B4DYF3 intact:EBI-517508|uniprotkb:Q96LV0|uniprotkb:Q9BT11|uniprotkb:Q9HAV6|uniprotkb:B2RDQ0|ensembl:ENSP00000442360|ensembl:ENSP00000499058|uniprotkb:Q6W3F3 psi-mi:ubp13_human(display_long)|uniprotkb:Ubiquitin-specific-processing protease 13(gene name synonym)|uniprotkb:Deubiquitinating enzyme 13(gene name synonym)|uniprotkb:Isopeptidase T-3(gene name synonym)|uniprotkb:USP13(gene name)|psi-mi:USP13(display_short)|uniprotkb:ISOT3(gene name synonym)|uniprotkb:Ubiquitin thioesterase 13(gene name synonym) psi-mi:dbloh_human(display_long)|uniprotkb:Second mitochondria-derived activator of caspase(gene name synonym)|uniprotkb:Direct IAP-binding protein with low pI(gene name synonym)|uniprotkb:DIABLO(gene name)|psi-mi:DIABLO(display_short)|uniprotkb:SMAC(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511562|imex:IM-12079-67 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003931.2|ensembl:ENSG00000058056(gene)|ensembl:ENST00000263966(transcript)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006914"(autophagy)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030318"(melanocyte differentiation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035523"(protein K29-linked deubiquitination)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0044313"(protein K6-linked deubiquitination)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0070628"(proteasome binding)|go:"GO:1904288"(BAT3 complex binding)|go:"GO:1904294"(positive regulation of ERAD pathway)|go:"GO:1904378"(maintenance of unfolded protein involved in ERAD pathway)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR009060(UBA-like)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR016652(Ubiquitinyl hydrolase)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|interpro:IPR041432|rcsb pdb:2L80|rcsb pdb:2LBC|reactome:R-HSA-5689880|reactome:R-HSA-8948751|ensembl:ENSP00000263966|ensembl:ENST00000496897|ensembl:ENSP00000417146|dip:DIP-53511N refseq:NP_001265231.1|refseq:NP_001265232.1|refseq:NP_001265233.1|refseq:NP_001265271.1|refseq:NP_620308.1|refseq:NP_063940.1|ensembl:ENST00000464942(transcript)|ensembl:ENSG00000184047(gene)|ensembl:ENST00000650715(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008631"(intrinsic apoptotic signaling pathway in response to oxidative stress)|go:"GO:0008635"(activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|interpro:IPR009062(Second mitochondria-derived activator of caspase/direct IAP-binding protein with low PI-like)|interpro:IPR015142(Second mitochondria-derived activator of caspase/Direct IAP-binding protein with low PI)|rcsb pdb:1FEW|dip:DIP-27627N|rcsb pdb:1G3F|rcsb pdb:1G73|rcsb pdb:1OXQ|rcsb pdb:1TW6|rcsb pdb:1XB0|rcsb pdb:1XB1|rcsb pdb:3D9U|rcsb pdb:3UIH|rcsb pdb:3UIJ|rcsb pdb:4TX5|rcsb pdb:6JX6|reactome:R-HSA-111457|reactome:R-HSA-111463|reactome:R-HSA-111464|reactome:R-HSA-111469|reactome:R-HSA-9627069 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:q6g2QmSYm3Xjoo+tv20s6cN8iHk9606 rogid:PkdIVYOS6o8pglwOXzsyD/frCqI9606 intact-crc:27E0E21ACEF06F81|rigid:F+vN9l12c3ZeJdNhEcnCURMY8K8 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q92995 uniprotkb:P36957 intact:EBI-714351|uniprotkb:D3DNS2|uniprotkb:Q96B25|intact:EBI-28978985|ensembl:ENSP00000263966|uniprotkb:A8K2S3|uniprotkb:B4DYF3 intact:EBI-351007|uniprotkb:Q9BQ32|uniprotkb:Q7LDY7|intact:EBI-2511564|uniprotkb:B7Z5W8|uniprotkb:E7ESY5|ensembl:ENSP00000335304 psi-mi:ubp13_human(display_long)|uniprotkb:Ubiquitin-specific-processing protease 13(gene name synonym)|uniprotkb:Deubiquitinating enzyme 13(gene name synonym)|uniprotkb:Isopeptidase T-3(gene name synonym)|uniprotkb:USP13(gene name)|psi-mi:USP13(display_short)|uniprotkb:ISOT3(gene name synonym)|uniprotkb:Ubiquitin thioesterase 13(gene name synonym) psi-mi:odo2_human(display_long)|uniprotkb:DLST(gene name)|psi-mi:DLST(display_short)|uniprotkb:DLTS(gene name synonym)|uniprotkb:Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex(gene name synonym)|uniprotkb:E2K(gene name synonym)|uniprotkb:2-oxoglutarate dehydrogenase complex component E2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511562|imex:IM-12079-67 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003931.2|ensembl:ENSG00000058056(gene)|ensembl:ENST00000263966(transcript)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006914"(autophagy)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030318"(melanocyte differentiation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035523"(protein K29-linked deubiquitination)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0044313"(protein K6-linked deubiquitination)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0070628"(proteasome binding)|go:"GO:1904288"(BAT3 complex binding)|go:"GO:1904294"(positive regulation of ERAD pathway)|go:"GO:1904378"(maintenance of unfolded protein involved in ERAD pathway)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR009060(UBA-like)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR016652(Ubiquitinyl hydrolase)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|interpro:IPR041432|rcsb pdb:2L80|rcsb pdb:2LBC|reactome:R-HSA-5689880|reactome:R-HSA-8948751|ensembl:ENSP00000263966|ensembl:ENST00000496897|ensembl:ENSP00000417146|dip:DIP-53511N refseq:NP_001924.2|ensembl:ENSG00000119689(gene)|ensembl:ENST00000334220(transcript)|go:"GO:0004149"(dihydrolipoyllysine-residue succinyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006103"(2-oxoglutarate metabolic process)|go:"GO:0006104"(succinyl-CoA metabolic process)|go:"GO:0016020"(membrane)|go:"GO:0016746"(acyltransferase activity)|go:"GO:0033512"(L-lysine catabolic process to acetyl-CoA via saccharopine)|go:"GO:0034451"(centriolar satellite)|go:"GO:0045252"(oxoglutarate dehydrogenase complex)|go:"GO:0106077"(histone succinylation)|interpro:IPR000089(Biotin/lipoyl attachment)|interpro:IPR001078(Catalytic domain of components of various dehydrogenase complexes)|interpro:IPR003016(2-oxo acid dehydrogenase, lipoyl-binding site)|interpro:IPR006255(Dihydrolipoamide succinyltransferase)|interpro:IPR011053(Single hybrid motif)|interpro:IPR023213|mint:P36957|rcsb pdb:6H05|reactome:R-HSA-389661|reactome:R-HSA-71064|reactome:R-HSA-71403 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:q6g2QmSYm3Xjoo+tv20s6cN8iHk9606 rogid:lZLUcTHB/dxXBTI/IXnSjyuVmBo9606 intact-crc:27E0E21ACEF06F81|rigid:F+vN9l12c3ZeJdNhEcnCURMY8K8 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q92995 uniprotkb:Q9HB71 intact:EBI-714351|uniprotkb:D3DNS2|uniprotkb:Q96B25|intact:EBI-28978985|ensembl:ENSP00000263966|uniprotkb:A8K2S3|uniprotkb:B4DYF3 intact:EBI-1047302|uniprotkb:O60666|ensembl:ENSP00000356652|uniprotkb:B2ZWH2|uniprotkb:Q5R371|uniprotkb:B3KSF1|uniprotkb:Q5R370 psi-mi:ubp13_human(display_long)|uniprotkb:Ubiquitin-specific-processing protease 13(gene name synonym)|uniprotkb:Deubiquitinating enzyme 13(gene name synonym)|uniprotkb:Isopeptidase T-3(gene name synonym)|uniprotkb:USP13(gene name)|psi-mi:USP13(display_short)|uniprotkb:ISOT3(gene name synonym)|uniprotkb:Ubiquitin thioesterase 13(gene name synonym) psi-mi:cybp_human(display_long)|uniprotkb:Siah-interacting protein(gene name synonym)|uniprotkb:S100A6-binding protein(gene name synonym)|uniprotkb:CACYBP(gene name)|psi-mi:CACYBP(display_short)|uniprotkb:S100A6BP(gene name synonym)|uniprotkb:SIP(gene name synonym)|uniprotkb:PNAS-107(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511562|imex:IM-12079-67 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003931.2|ensembl:ENSG00000058056(gene)|ensembl:ENST00000263966(transcript)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006914"(autophagy)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030318"(melanocyte differentiation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035523"(protein K29-linked deubiquitination)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0044313"(protein K6-linked deubiquitination)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0070628"(proteasome binding)|go:"GO:1904288"(BAT3 complex binding)|go:"GO:1904294"(positive regulation of ERAD pathway)|go:"GO:1904378"(maintenance of unfolded protein involved in ERAD pathway)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR009060(UBA-like)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR016652(Ubiquitinyl hydrolase)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|interpro:IPR041432|rcsb pdb:2L80|rcsb pdb:2LBC|reactome:R-HSA-5689880|reactome:R-HSA-8948751|ensembl:ENSP00000263966|ensembl:ENST00000496897|ensembl:ENSP00000417146|dip:DIP-53511N go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR015120(Siah interacting protein, N terminal)|interpro:IPR037201|interpro:IPR037893|mint:Q9HB71|rcsb pdb:1X5M|rcsb pdb:2A25|rcsb pdb:2A26|go:"GO:0071277"(cellular response to calcium ion)|refseq:NP_001007215.1|refseq:NP_055227.1|ensembl:ENSG00000116161(gene)|ensembl:ENST00000367679(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0015631"(tubulin binding)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0044297"(cell body)|go:"GO:0044548"(S100 protein binding)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0060416"(response to growth hormone)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070062"(extracellular exosome)|refseq:XP_016856535.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:q6g2QmSYm3Xjoo+tv20s6cN8iHk9606 rogid:mvv1o19mLHBS3FDnATyOFsDoZvk9606 intact-crc:27E0E21ACEF06F81|rigid:F+vN9l12c3ZeJdNhEcnCURMY8K8 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P54578 uniprotkb:P62195 intact:EBI-1048016|uniprotkb:Q53XY5|uniprotkb:B7Z4N8|uniprotkb:J3QRZ5|ensembl:ENSP00000261601 intact:EBI-357745|uniprotkb:O35051|uniprotkb:O43208|uniprotkb:P52915|uniprotkb:P47210|uniprotkb:P52916|uniprotkb:A8K763|uniprotkb:A8K3Z3|ensembl:ENSP00000310572 psi-mi:ubp14_human(display_long)|uniprotkb:USP14(gene name)|psi-mi:USP14(display_short)|uniprotkb:TGT(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 14(gene name synonym)|uniprotkb:Deubiquitinating enzyme 14(gene name synonym)|uniprotkb:Ubiquitin thioesterase 14(gene name synonym) psi-mi:prs8_human(display_long)|uniprotkb:PSMC5(gene name)|psi-mi:PSMC5(display_short)|uniprotkb:SUG1(gene name synonym)|uniprotkb:Proteasome 26S subunit ATPase 5(gene name synonym)|uniprotkb:Proteasome subunit p45(gene name synonym)|uniprotkb:p45/SUG(gene name synonym)|uniprotkb:Thyroid hormone receptor-interacting protein 1(gene name synonym)|uniprotkb:26S proteasome AAA-ATPase subunit RPT6(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511607|imex:IM-12079-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032411.1|refseq:NP_005142.1|ensembl:ENSG00000101557(gene)|ensembl:ENST00000261601(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0050920"(regulation of chemotaxis)|go:"GO:0045087"(innate immune response)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903070"(negative regulation of ER-associated ubiquitin-dependent protein catabolic process)|interpro:IPR000626(Ubiquitin)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR019954|interpro:IPR028889|interpro:IPR029071|interpro:IPR038765|interpro:IPR044635|mint:P54578|rcsb pdb:2AYN|rcsb pdb:2AYO|rcsb pdb:5GJQ|rcsb pdb:6IIK|rcsb pdb:6IIL|rcsb pdb:6IIM|rcsb pdb:6IIN|rcsb pdb:6LVS|reactome:R-HSA-5689880|go:"GO:0070628"(proteasome binding) refseq:NP_001186092.1|refseq:NP_002796.4|reactome:R-HSA-195253|ensembl:ENSG00000087191(gene)|ensembl:ENST00000310144(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0017025"(TBP-class protein binding)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031531"(thyrotropin-releasing hormone receptor binding)|go:"GO:0031595"(nuclear proteasome complex)|go:"GO:0031597"(cytosolic proteasome complex)|go:"GO:0036402"(proteasome-activating activity)|go:"GO:0043069"(negative regulation of programmed cell death)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045899"(positive regulation of RNA polymerase II transcription preinitiation complex assembly)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0090261"(positive regulation of inclusion body assembly)|go:"GO:0098794"(postsynapse)|go:"GO:0140296"(general transcription initiation factor binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR005937(26S proteasome subunit P45)|interpro:IPR027417|interpro:IPR032501|interpro:IPR041569|mint:P62195|rcsb pdb:2KRK|rcsb pdb:3KW6|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4G|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VGZ|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHJ|rcsb pdb:5VHM|rcsb pdb:5VHN|rcsb pdb:5VHO|rcsb pdb:5VHP|rcsb pdb:5VHQ|rcsb pdb:5VHR|rcsb pdb:5VHS|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|dip:DIP-36645N psi-mi:"MI:0469"(intact) - crc64:29C6410C4A85A7F7 figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:5hXfHmHds5nuvdlFYWoB/G6nvmk9606 rogid:zgUTOX/O4m86U/Nf+pnT7u0m0gY9606 intact-crc:7855E2C9AE60650B|rigid:3igOECQSvuddozuHzQmwxuBVNPI false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P54578 uniprotkb:O00232 intact:EBI-1048016|uniprotkb:Q53XY5|uniprotkb:B7Z4N8|uniprotkb:J3QRZ5|ensembl:ENSP00000261601 intact:EBI-359733|uniprotkb:Q53HA2|uniprotkb:Q6P053|ensembl:ENSP00000348442|uniprotkb:A6NP15 psi-mi:ubp14_human(display_long)|uniprotkb:USP14(gene name)|psi-mi:USP14(display_short)|uniprotkb:TGT(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 14(gene name synonym)|uniprotkb:Deubiquitinating enzyme 14(gene name synonym)|uniprotkb:Ubiquitin thioesterase 14(gene name synonym) psi-mi:psd12_human(display_long)|uniprotkb:PSMD12(gene name)|psi-mi:PSMD12(display_short)|uniprotkb:26S proteasome regulatory subunit p55(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN5(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511607|imex:IM-12079-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032411.1|refseq:NP_005142.1|ensembl:ENSG00000101557(gene)|ensembl:ENST00000261601(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0050920"(regulation of chemotaxis)|go:"GO:0045087"(innate immune response)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903070"(negative regulation of ER-associated ubiquitin-dependent protein catabolic process)|interpro:IPR000626(Ubiquitin)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR019954|interpro:IPR028889|interpro:IPR029071|interpro:IPR038765|interpro:IPR044635|mint:P54578|rcsb pdb:2AYN|rcsb pdb:2AYO|rcsb pdb:5GJQ|rcsb pdb:6IIK|rcsb pdb:6IIL|rcsb pdb:6IIM|rcsb pdb:6IIN|rcsb pdb:6LVS|reactome:R-HSA-5689880|go:"GO:0070628"(proteasome binding) refseq:NP_002807.1|refseq:NP_001303270.1|ensembl:ENSG00000197170(gene)|ensembl:ENST00000356126(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0008541"(proteasome regulatory particle, lid subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0031595"(nuclear proteasome complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR035297|interpro:IPR036388|interpro:IPR036390|interpro:IPR040134|interpro:IPR040896|mint:O00232|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VGZ|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHS|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|rcsb pdb:5VFS|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-5687128|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|refseq:NP_777360.1|dip:DIP-27549N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:5hXfHmHds5nuvdlFYWoB/G6nvmk9606 rogid:4tzcvfL/EqQRcUpoMtxVU0WC+TU9606 intact-crc:7855E2C9AE60650B|rigid:3igOECQSvuddozuHzQmwxuBVNPI false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P54578 uniprotkb:Q9UNM6 intact:EBI-1048016|uniprotkb:Q53XY5|uniprotkb:B7Z4N8|uniprotkb:J3QRZ5|ensembl:ENSP00000261601 intact:EBI-356070|uniprotkb:O75831|uniprotkb:Q9UNV3|uniprotkb:Q53XU2|intact:EBI-1058479|uniprotkb:B3KT15|ensembl:ENSP00000436186 psi-mi:ubp14_human(display_long)|uniprotkb:USP14(gene name)|psi-mi:USP14(display_short)|uniprotkb:TGT(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 14(gene name synonym)|uniprotkb:Deubiquitinating enzyme 14(gene name synonym)|uniprotkb:Ubiquitin thioesterase 14(gene name synonym) psi-mi:psd13_human(display_long)|uniprotkb:PSMD13(gene name)|psi-mi:PSMD13(display_short)|uniprotkb:26S proteasome regulatory subunit S11(gene name synonym)|uniprotkb:26S proteasome regulatory subunit p40.5(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN9(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511607|imex:IM-12079-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032411.1|refseq:NP_005142.1|ensembl:ENSG00000101557(gene)|ensembl:ENST00000261601(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0050920"(regulation of chemotaxis)|go:"GO:0045087"(innate immune response)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903070"(negative regulation of ER-associated ubiquitin-dependent protein catabolic process)|interpro:IPR000626(Ubiquitin)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR019954|interpro:IPR028889|interpro:IPR029071|interpro:IPR038765|interpro:IPR044635|mint:P54578|rcsb pdb:2AYN|rcsb pdb:2AYO|rcsb pdb:5GJQ|rcsb pdb:6IIK|rcsb pdb:6IIL|rcsb pdb:6IIM|rcsb pdb:6IIN|rcsb pdb:6LVS|reactome:R-HSA-5689880|go:"GO:0070628"(proteasome binding) refseq:NP_002808.3|refseq:NP_787128.2|dip:DIP-27576N|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|rcsb pdb:6MSK|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|ensembl:ENSG00000185627(gene)|ensembl:ENST00000532097(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007127"(meiosis I)|go:"GO:0008541"(proteasome regulatory particle, lid subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0043248"(proteasome assembly)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR035298|interpro:IPR036390|mint:Q9UNM6|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VGZ|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHS|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:5hXfHmHds5nuvdlFYWoB/G6nvmk9606 rogid:iOxE62MMeGx+aqsrir/LukJqeho9606 intact-crc:7855E2C9AE60650B|rigid:3igOECQSvuddozuHzQmwxuBVNPI false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P54578 uniprotkb:O43242 intact:EBI-1048016|uniprotkb:Q53XY5|uniprotkb:B7Z4N8|uniprotkb:J3QRZ5|ensembl:ENSP00000261601 intact:EBI-357622|uniprotkb:Q96EI2|uniprotkb:Q9BQA4|ensembl:ENSP00000264639|uniprotkb:B4DT72|uniprotkb:B3KMW9 psi-mi:ubp14_human(display_long)|uniprotkb:USP14(gene name)|psi-mi:USP14(display_short)|uniprotkb:TGT(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 14(gene name synonym)|uniprotkb:Deubiquitinating enzyme 14(gene name synonym)|uniprotkb:Ubiquitin thioesterase 14(gene name synonym) psi-mi:psmd3_human(display_long)|uniprotkb:PSMD3(gene name)|psi-mi:PSMD3(display_short)|uniprotkb:Proteasome subunit p58(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S3(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN3(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511607|imex:IM-12079-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032411.1|refseq:NP_005142.1|ensembl:ENSG00000101557(gene)|ensembl:ENST00000261601(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0050920"(regulation of chemotaxis)|go:"GO:0045087"(innate immune response)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903070"(negative regulation of ER-associated ubiquitin-dependent protein catabolic process)|interpro:IPR000626(Ubiquitin)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR019954|interpro:IPR028889|interpro:IPR029071|interpro:IPR038765|interpro:IPR044635|mint:P54578|rcsb pdb:2AYN|rcsb pdb:2AYO|rcsb pdb:5GJQ|rcsb pdb:6IIK|rcsb pdb:6IIL|rcsb pdb:6IIM|rcsb pdb:6IIN|rcsb pdb:6LVS|reactome:R-HSA-5689880|go:"GO:0070628"(proteasome binding) ensembl:ENSG00000108344(gene)|ensembl:ENST00000264639(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008541"(proteasome regulatory particle, lid subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013586(26S proteasome regulatory subunit, C-terminal)|interpro:IPR035267|interpro:IPR036390|mint:O43242|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VGZ|rcsb pdb:5VHF|reactome:R-HSA-174113|reactome:R-HSA-174154|rcsb pdb:5VHH|rcsb pdb:5VHI|reactome:R-HSA-174178|rcsb pdb:5VHS|reactome:R-HSA-174184|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6MSH|reactome:R-HSA-180534|rcsb pdb:6MSJ|reactome:R-HSA-180585|reactome:R-HSA-187577|rcsb pdb:6MSK|reactome:R-HSA-195253|reactome:R-HSA-202424|rcsb pdb:6WJD|reactome:R-HSA-211733|rcsb pdb:6WJN|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-174084|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5607761|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|reactome:R-HSA-8854050|refseq:NP_002800.2|dip:DIP-27571N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:5hXfHmHds5nuvdlFYWoB/G6nvmk9606 rogid:C6CStW89nIAA3mzubyv5wfBwPHk9606 intact-crc:7855E2C9AE60650B|rigid:3igOECQSvuddozuHzQmwxuBVNPI false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P54578 uniprotkb:P62333 intact:EBI-1048016|uniprotkb:Q53XY5|uniprotkb:B7Z4N8|uniprotkb:J3QRZ5|ensembl:ENSP00000261601 intact:EBI-357669|uniprotkb:Q92524|uniprotkb:P49719|uniprotkb:Q6IBU3|uniprotkb:B2R975|ensembl:ENSP00000401802 psi-mi:ubp14_human(display_long)|uniprotkb:USP14(gene name)|psi-mi:USP14(display_short)|uniprotkb:TGT(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 14(gene name synonym)|uniprotkb:Deubiquitinating enzyme 14(gene name synonym)|uniprotkb:Ubiquitin thioesterase 14(gene name synonym) psi-mi:prs10_human(display_long)|uniprotkb:PSMC6(gene name)|psi-mi:PSMC6(display_short)|uniprotkb:SUG2(gene name synonym)|uniprotkb:Proteasome 26S subunit ATPase 6(gene name synonym)|uniprotkb:Proteasome subunit p42(gene name synonym)|uniprotkb:26S proteasome AAA-ATPase subunit RPT4(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511607|imex:IM-12079-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032411.1|refseq:NP_005142.1|ensembl:ENSG00000101557(gene)|ensembl:ENST00000261601(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0050920"(regulation of chemotaxis)|go:"GO:0045087"(innate immune response)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903070"(negative regulation of ER-associated ubiquitin-dependent protein catabolic process)|interpro:IPR000626(Ubiquitin)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR019954|interpro:IPR028889|interpro:IPR029071|interpro:IPR038765|interpro:IPR044635|mint:P54578|rcsb pdb:2AYN|rcsb pdb:2AYO|rcsb pdb:5GJQ|rcsb pdb:6IIK|rcsb pdb:6IIL|rcsb pdb:6IIM|rcsb pdb:6IIN|rcsb pdb:6LVS|reactome:R-HSA-5689880|go:"GO:0070628"(proteasome binding) refseq:NP_002797.3|ensembl:ENST00000445930(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|ensembl:ENSG00000100519(gene)|go:"GO:0005829"(cytosol)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031597"(cytosolic proteasome complex)|go:"GO:0036402"(proteasome-activating activity)|go:"GO:0042802"(identical protein binding)|interpro:IPR032501|interpro:IPR035263|interpro:IPR041569|mint:P62333|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4G|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VGZ|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHJ|rcsb pdb:5VHM|rcsb pdb:5VHN|rcsb pdb:5VHO|rcsb pdb:5VHP|rcsb pdb:5VHQ|rcsb pdb:5VHR|rcsb pdb:5VHS|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6WJN|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|go:"GO:0045899"(positive regulation of RNA polymerase II transcription preinitiation complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090261"(positive regulation of inclusion body assembly)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR005937(26S proteasome subunit P45)|interpro:IPR027417|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|reactome:R-HSA-75815|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-174184|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|dip:DIP-38150N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:5hXfHmHds5nuvdlFYWoB/G6nvmk9606 rogid:QE8jzSEp1bpzhOi/oAAnV18QK249606 intact-crc:7855E2C9AE60650B|rigid:3igOECQSvuddozuHzQmwxuBVNPI false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P54578 uniprotkb:Q99460 intact:EBI-1048016|uniprotkb:Q53XY5|uniprotkb:B7Z4N8|uniprotkb:J3QRZ5|ensembl:ENSP00000261601 intact:EBI-357874|uniprotkb:Q24JU0|uniprotkb:Q53TI2|uniprotkb:Q6GMU5|uniprotkb:Q6P2P4|uniprotkb:Q6PJM7|uniprotkb:Q6PKG9|uniprotkb:B8ZZH9|uniprotkb:Q86VU1|uniprotkb:Q8IV79|ensembl:ENSP00000309474|ensembl:ENSP00000503068 psi-mi:ubp14_human(display_long)|uniprotkb:USP14(gene name)|psi-mi:USP14(display_short)|uniprotkb:TGT(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 14(gene name synonym)|uniprotkb:Deubiquitinating enzyme 14(gene name synonym)|uniprotkb:Ubiquitin thioesterase 14(gene name synonym) psi-mi:psmd1_human(display_long)|uniprotkb:PSMD1(gene name)|psi-mi:PSMD1(display_short)|uniprotkb:26S proteasome regulatory subunit RPN2(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S1(gene name synonym)|uniprotkb:26S proteasome subunit p112(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511607|imex:IM-12079-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032411.1|refseq:NP_005142.1|ensembl:ENSG00000101557(gene)|ensembl:ENST00000261601(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0050920"(regulation of chemotaxis)|go:"GO:0045087"(innate immune response)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903070"(negative regulation of ER-associated ubiquitin-dependent protein catabolic process)|interpro:IPR000626(Ubiquitin)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR019954|interpro:IPR028889|interpro:IPR029071|interpro:IPR038765|interpro:IPR044635|mint:P54578|rcsb pdb:2AYN|rcsb pdb:2AYO|rcsb pdb:5GJQ|rcsb pdb:6IIK|rcsb pdb:6IIL|rcsb pdb:6IIM|rcsb pdb:6IIN|rcsb pdb:6LVS|reactome:R-HSA-5689880|go:"GO:0070628"(proteasome binding) refseq:NP_001177966.1|refseq:NP_002798.2|dip:DIP-27548N|ensembl:ENSG00000173692(gene)|ensembl:ENST00000308696(transcript)|ensembl:ENST00000677230(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034515"(proteasome storage granule)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|interpro:IPR002015(Proteasome/cyclosome, regulatory subunit)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016642(26S proteasome regulatory complex, non-ATPase subcomplex, Rpn2/Psmd1 subunit)|interpro:IPR035266|interpro:IPR040623|mint:Q99460|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5V1Y|rcsb pdb:5V1Z|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VGZ|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHS|rcsb pdb:6CO4|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6OI4|rcsb pdb:6UYI|rcsb pdb:6UYJ|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-382556|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:5hXfHmHds5nuvdlFYWoB/G6nvmk9606 rogid:aGYxoT30PhzvF/CiurQLDb8Ewrs9606 intact-crc:7855E2C9AE60650B|rigid:3igOECQSvuddozuHzQmwxuBVNPI false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P54578 uniprotkb:P51665 intact:EBI-1048016|uniprotkb:Q53XY5|uniprotkb:B7Z4N8|uniprotkb:J3QRZ5|ensembl:ENSP00000261601 intact:EBI-357659|uniprotkb:Q6PKI2|uniprotkb:Q96E97|ensembl:ENSP00000219313|uniprotkb:D3DWS9 psi-mi:ubp14_human(display_long)|uniprotkb:USP14(gene name)|psi-mi:USP14(display_short)|uniprotkb:TGT(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 14(gene name synonym)|uniprotkb:Deubiquitinating enzyme 14(gene name synonym)|uniprotkb:Ubiquitin thioesterase 14(gene name synonym) psi-mi:psmd7_human(display_long)|uniprotkb:PSMD7(gene name)|psi-mi:PSMD7(display_short)|uniprotkb:MOV34L(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN8(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S12(gene name synonym)|uniprotkb:Proteasome subunit p40(gene name synonym)|uniprotkb:Mov34 protein homolog(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511607|imex:IM-12079-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032411.1|refseq:NP_005142.1|ensembl:ENSG00000101557(gene)|ensembl:ENST00000261601(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0050920"(regulation of chemotaxis)|go:"GO:0045087"(innate immune response)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903070"(negative regulation of ER-associated ubiquitin-dependent protein catabolic process)|interpro:IPR000626(Ubiquitin)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR019954|interpro:IPR028889|interpro:IPR029071|interpro:IPR038765|interpro:IPR044635|mint:P54578|rcsb pdb:2AYN|rcsb pdb:2AYO|rcsb pdb:5GJQ|rcsb pdb:6IIK|rcsb pdb:6IIL|rcsb pdb:6IIM|rcsb pdb:6IIN|rcsb pdb:6LVS|reactome:R-HSA-5689880|go:"GO:0070628"(proteasome binding) refseq:NP_002802.2|rcsb pdb:5T0J|ensembl:ENSG00000103035(gene)|ensembl:ENST00000219313(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0016020"(membrane)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070122"(isopeptidase activity)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR024969|interpro:IPR033858|interpro:IPR037518|mint:P51665|rcsb pdb:2O95|rcsb pdb:2O96|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VGZ|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHS|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-180534|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-195253|reactome:R-HSA-5676590|reactome:R-HSA-202424|reactome:R-HSA-5678895|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-2871837|reactome:R-HSA-5689880|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-6798695|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-68827|reactome:R-HSA-4641258|reactome:R-HSA-68949|reactome:R-HSA-5358346|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|dip:DIP-27572N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:5hXfHmHds5nuvdlFYWoB/G6nvmk9606 rogid:HJaBTx4pIiSDIArqueuNRvhzVvU9606 intact-crc:7855E2C9AE60650B|rigid:3igOECQSvuddozuHzQmwxuBVNPI false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P54578 uniprotkb:O00487 intact:EBI-1048016|uniprotkb:Q53XY5|uniprotkb:B7Z4N8|uniprotkb:J3QRZ5|ensembl:ENSP00000261601 intact:EBI-722193|uniprotkb:O00176|uniprotkb:B3KNW2|ensembl:ENSP00000386541 psi-mi:ubp14_human(display_long)|uniprotkb:USP14(gene name)|psi-mi:USP14(display_short)|uniprotkb:TGT(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 14(gene name synonym)|uniprotkb:Deubiquitinating enzyme 14(gene name synonym)|uniprotkb:Ubiquitin thioesterase 14(gene name synonym) psi-mi:psde_human(display_long)|uniprotkb:26S proteasome regulatory subunit RPN11(gene name synonym)|uniprotkb:26S proteasome-associated PAD1 homolog 1(gene name synonym)|uniprotkb:PSMD14(gene name)|psi-mi:PSMD14(display_short)|uniprotkb:POH1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511607|imex:IM-12079-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032411.1|refseq:NP_005142.1|ensembl:ENSG00000101557(gene)|ensembl:ENST00000261601(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0050920"(regulation of chemotaxis)|go:"GO:0045087"(innate immune response)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903070"(negative regulation of ER-associated ubiquitin-dependent protein catabolic process)|interpro:IPR000626(Ubiquitin)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR019954|interpro:IPR028889|interpro:IPR029071|interpro:IPR038765|interpro:IPR044635|mint:P54578|rcsb pdb:2AYN|rcsb pdb:2AYO|rcsb pdb:5GJQ|rcsb pdb:6IIK|rcsb pdb:6IIL|rcsb pdb:6IIM|rcsb pdb:6IIN|rcsb pdb:6LVS|reactome:R-HSA-5689880|go:"GO:0070628"(proteasome binding) refseq:NP_005796.1|ensembl:ENSG00000115233(gene)|ensembl:ENST00000409682(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008541"(proteasome regulatory particle, lid subcomplex)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0031597"(cytosolic proteasome complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0046872"(metal ion binding)|go:"GO:0061133"(endopeptidase activator activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0061578"(Lys63-specific deubiquitinase activity)|go:"GO:0070122"(isopeptidase activity)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0070628"(proteasome binding)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR024969|interpro:IPR035299|interpro:IPR037518|mint:O00487|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VGZ|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHS|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5689901|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:5hXfHmHds5nuvdlFYWoB/G6nvmk9606 rogid:pSM+755ZbQisR5S0ZivcYBu9Bc49606 intact-crc:7855E2C9AE60650B|rigid:3igOECQSvuddozuHzQmwxuBVNPI false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P54578 uniprotkb:Q15008 intact:EBI-1048016|uniprotkb:Q53XY5|uniprotkb:B7Z4N8|uniprotkb:J3QRZ5|ensembl:ENSP00000261601 intact:EBI-359701|uniprotkb:E9PHI9|uniprotkb:A8K2E0|ensembl:ENSP00000295901|uniprotkb:Q6UV22 psi-mi:ubp14_human(display_long)|uniprotkb:USP14(gene name)|psi-mi:USP14(display_short)|uniprotkb:TGT(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 14(gene name synonym)|uniprotkb:Deubiquitinating enzyme 14(gene name synonym)|uniprotkb:Ubiquitin thioesterase 14(gene name synonym) psi-mi:psmd6_human(display_long)|uniprotkb:PSMD6(gene name)|psi-mi:PSMD6(display_short)|uniprotkb:KIAA0107(gene name synonym)|uniprotkb:PFAAP4(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S10(gene name synonym)|uniprotkb:p42A(gene name synonym)|uniprotkb:Proteasome regulatory particle subunit p44S10(gene name synonym)|uniprotkb:Phosphonoformate immuno-associated protein 4(gene name synonym)|uniprotkb:Breast cancer-associated protein SGA-113M(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN7(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511607|imex:IM-12079-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032411.1|refseq:NP_005142.1|ensembl:ENSG00000101557(gene)|ensembl:ENST00000261601(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0050920"(regulation of chemotaxis)|go:"GO:0045087"(innate immune response)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903070"(negative regulation of ER-associated ubiquitin-dependent protein catabolic process)|interpro:IPR000626(Ubiquitin)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR019954|interpro:IPR028889|interpro:IPR029071|interpro:IPR038765|interpro:IPR044635|mint:P54578|rcsb pdb:2AYN|rcsb pdb:2AYO|rcsb pdb:5GJQ|rcsb pdb:6IIK|rcsb pdb:6IIL|rcsb pdb:6IIM|rcsb pdb:6IIN|rcsb pdb:6LVS|reactome:R-HSA-5689880|go:"GO:0070628"(proteasome binding) refseq:NP_055629.1|ensembl:ENSG00000163636(gene)|ensembl:ENST00000295901(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019585|interpro:IPR035268|interpro:IPR036390|mint:Q15008|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VGZ|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHS|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSG|rcsb pdb:6MSH|reactome:R-HSA-5358346|reactome:R-HSA-1236978|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-1236974|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|reactome:R-HSA-69601|reactome:R-HSA-69481|refseq:NP_001258708.1|refseq:NP_001258709.1|refseq:NP_001258710.1|dip:DIP-27590N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:5hXfHmHds5nuvdlFYWoB/G6nvmk9606 rogid:ULOM02v6J56vZLlAGn7wN3N6Efw9606 intact-crc:7855E2C9AE60650B|rigid:3igOECQSvuddozuHzQmwxuBVNPI false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P54578 uniprotkb:Q9Y5K5 intact:EBI-1048016|uniprotkb:Q53XY5|uniprotkb:B7Z4N8|uniprotkb:J3QRZ5|ensembl:ENSP00000261601 intact:EBI-1051183|uniprotkb:Q5LJA6|uniprotkb:Q5LJA7|uniprotkb:Q8TBS4|uniprotkb:Q96BJ9|uniprotkb:Q9H1W5|uniprotkb:Q9P0I3|uniprotkb:Q9UQN2|ensembl:ENSP00000356425 psi-mi:ubp14_human(display_long)|uniprotkb:USP14(gene name)|psi-mi:USP14(display_short)|uniprotkb:TGT(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 14(gene name synonym)|uniprotkb:Deubiquitinating enzyme 14(gene name synonym)|uniprotkb:Ubiquitin thioesterase 14(gene name synonym) psi-mi:uchl5_human(display_long)|uniprotkb:Ubiquitin thioesterase L5(gene name synonym)|uniprotkb:Ubiquitin C-terminal hydrolase UCH37(gene name synonym)|uniprotkb:UCHL5(gene name)|psi-mi:UCHL5(display_short)|uniprotkb:UCH37(gene name synonym)|uniprotkb:AD-019(orf name)|uniprotkb:CGI-70(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511607|imex:IM-12079-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032411.1|refseq:NP_005142.1|ensembl:ENSG00000101557(gene)|ensembl:ENST00000261601(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0050920"(regulation of chemotaxis)|go:"GO:0045087"(innate immune response)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903070"(negative regulation of ER-associated ubiquitin-dependent protein catabolic process)|interpro:IPR000626(Ubiquitin)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR019954|interpro:IPR028889|interpro:IPR029071|interpro:IPR038765|interpro:IPR044635|mint:P54578|rcsb pdb:2AYN|rcsb pdb:2AYO|rcsb pdb:5GJQ|rcsb pdb:6IIK|rcsb pdb:6IIL|rcsb pdb:6IIM|rcsb pdb:6IIN|rcsb pdb:6LVS|reactome:R-HSA-5689880|go:"GO:0070628"(proteasome binding) refseq:NP_001186190.1|refseq:NP_001186191.1|refseq:NP_001186192.1|refseq:NP_057068.1|ensembl:ENSG00000116750(gene)|ensembl:ENST00000367455(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0021670"(lateral ventricle development)|go:"GO:0030901"(midbrain development)|go:"GO:0031011"(Ino80 complex)|go:"GO:0031597"(cytosolic proteasome complex)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0048853"(forebrain morphogenesis)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070628"(proteasome binding)|interpro:IPR001578(Peptidase C12, ubiquitin carboxyl-terminal hydrolase 1)|interpro:IPR017390(Ubiquitinyl hydrolase, UCH37 type)|interpro:IPR033837|interpro:IPR036959|interpro:IPR038765|interpro:IPR041507|mint:Q9Y5K5|rcsb pdb:3A7S|rcsb pdb:3IHR|rcsb pdb:3RII|rcsb pdb:3RIS|rcsb pdb:3TB3|rcsb pdb:4UEL|rcsb pdb:4UEM|rcsb pdb:4UF5|rcsb pdb:4UF6|rcsb pdb:4WLP|reactome:R-HSA-2173788|reactome:R-HSA-5689603|dip:DIP-42671N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:5hXfHmHds5nuvdlFYWoB/G6nvmk9606 rogid:gRm5ttq5Tc0cBIOQ1ut2ugzbMTY9606 intact-crc:7855E2C9AE60650B|rigid:3igOECQSvuddozuHzQmwxuBVNPI false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P54578 uniprotkb:P43686 intact:EBI-1048016|uniprotkb:Q53XY5|uniprotkb:B7Z4N8|uniprotkb:J3QRZ5|ensembl:ENSP00000261601 intact:EBI-743997|uniprotkb:Q96FV5|uniprotkb:Q9UBM3|uniprotkb:Q9UEX3|ensembl:ENSP00000157812|ensembl:ENSP00000487367 psi-mi:ubp14_human(display_long)|uniprotkb:USP14(gene name)|psi-mi:USP14(display_short)|uniprotkb:TGT(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 14(gene name synonym)|uniprotkb:Deubiquitinating enzyme 14(gene name synonym)|uniprotkb:Ubiquitin thioesterase 14(gene name synonym) psi-mi:prs6b_human(display_long)|uniprotkb:Proteasome 26S subunit ATPase 4(gene name synonym)|uniprotkb:MB67-interacting protein(gene name synonym)|uniprotkb:PSMC4(gene name)|psi-mi:PSMC4(display_short)|uniprotkb:TBP7(gene name synonym)|uniprotkb:MIP224(gene name synonym)|uniprotkb:Tat-binding protein 7(gene name synonym)|uniprotkb:26S proteasome AAA-ATPase subunit RPT3(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511607|imex:IM-12079-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032411.1|refseq:NP_005142.1|ensembl:ENSG00000101557(gene)|ensembl:ENST00000261601(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0050920"(regulation of chemotaxis)|go:"GO:0045087"(innate immune response)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903070"(negative regulation of ER-associated ubiquitin-dependent protein catabolic process)|interpro:IPR000626(Ubiquitin)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR019954|interpro:IPR028889|interpro:IPR029071|interpro:IPR038765|interpro:IPR044635|mint:P54578|rcsb pdb:2AYN|rcsb pdb:2AYO|rcsb pdb:5GJQ|rcsb pdb:6IIK|rcsb pdb:6IIL|rcsb pdb:6IIM|rcsb pdb:6IIN|rcsb pdb:6LVS|reactome:R-HSA-5689880|go:"GO:0070628"(proteasome binding) refseq:NP_006494.1|refseq:NP_694546.1|dip:DIP-29274N|ensembl:ENSG00000013275(gene)|ensembl:ENSG00000281221(gene)|ensembl:ENST00000157812(transcript)|ensembl:ENST00000629691(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0001824"(blastocyst development)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0030163"(protein catabolic process)|go:"GO:0031597"(cytosolic proteasome complex)|go:"GO:0036402"(proteasome-activating activity)|go:"GO:0045202"(synapse)|go:"GO:0045899"(positive regulation of RNA polymerase II transcription preinitiation complex assembly)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR005937(26S proteasome subunit P45)|interpro:IPR027417|interpro:IPR032501|interpro:IPR035256|interpro:IPR041569|mint:P43686|rcsb pdb:2DVW|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4G|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VGZ|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHJ|rcsb pdb:5VHM|rcsb pdb:5VHN|rcsb pdb:5VHO|rcsb pdb:5VHP|rcsb pdb:5VHQ|rcsb pdb:5VHR|rcsb pdb:5VHS|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|reactome:R-HSA-69601 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:5hXfHmHds5nuvdlFYWoB/G6nvmk9606 rogid:ZwHUFX8vJa8IPZi000dHiFtUtlM9606 intact-crc:7855E2C9AE60650B|rigid:3igOECQSvuddozuHzQmwxuBVNPI false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P54578 uniprotkb:Q99666 intact:EBI-1048016|uniprotkb:Q53XY5|uniprotkb:B7Z4N8|uniprotkb:J3QRZ5|ensembl:ENSP00000261601 intact:EBI-2511609|intact:EBI-28976430|ensembl:ENSP00000016946|ensembl:ENSP00000330842|uniprotkb:Q53QN2|uniprotkb:Q53T03|uniprotkb:Q59GM7|intact:EBI-2691891|intact:EBI-2555607|uniprotkb:Q9H0B2 psi-mi:ubp14_human(display_long)|uniprotkb:USP14(gene name)|psi-mi:USP14(display_short)|uniprotkb:TGT(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 14(gene name synonym)|uniprotkb:Deubiquitinating enzyme 14(gene name synonym)|uniprotkb:Ubiquitin thioesterase 14(gene name synonym) psi-mi:rgpd5_human(display_long)|uniprotkb:RGP5(gene name synonym)|uniprotkb:RGPD7(gene name synonym)|uniprotkb:RANBP2L2(gene name synonym)|uniprotkb:RGP6(gene name synonym)|uniprotkb:Ran-binding protein 2-like 1/2(gene name synonym)|uniprotkb:Sperm membrane protein BS-63(gene name synonym)|uniprotkb:RGPD5(gene name)|psi-mi:RGPD5(display_short)|uniprotkb:RGP7(gene name synonym)|uniprotkb:RGPD6(gene name)|psi-mi:RGPD6(display_short)|uniprotkb:RANBP2L1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511607|imex:IM-12079-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032411.1|refseq:NP_005142.1|ensembl:ENSG00000101557(gene)|ensembl:ENST00000261601(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0050920"(regulation of chemotaxis)|go:"GO:0045087"(innate immune response)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903070"(negative regulation of ER-associated ubiquitin-dependent protein catabolic process)|interpro:IPR000626(Ubiquitin)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR019954|interpro:IPR028889|interpro:IPR029071|interpro:IPR038765|interpro:IPR044635|mint:P54578|rcsb pdb:2AYN|rcsb pdb:2AYO|rcsb pdb:5GJQ|rcsb pdb:6IIK|rcsb pdb:6IIL|rcsb pdb:6IIM|rcsb pdb:6IIN|rcsb pdb:6LVS|reactome:R-HSA-5689880|go:"GO:0070628"(proteasome binding) ensembl:ENSG00000015568(gene)|ensembl:ENSG00000183054(gene)|ensembl:ENST00000016946(transcript)|go:"GO:0005643"(nuclear pore)|go:"GO:0005737"(cytoplasm)|go:"GO:0006607"(NLS-bearing protein import into nucleus)|ensembl:ENST00000329516(transcript)|go:"GO:0050790"(regulation of catalytic activity)|interpro:IPR000156(Ran Binding Protein 1)|interpro:IPR000237(GRIP)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR019734|interpro:IPR032023|refseq:NP_001032955.1|refseq:NP_001116835.1|refseq:NP_005045.2|refseq:NP_115636.1|ensembl:ENSP00000016946|ensembl:ENST00000272454|ensembl:ENSP00000272454|ensembl:ENSP00000330842|ensembl:ENST00000330331|ensembl:ENSP00000330023|ensembl:ENST00000393283|ensembl:ENSP00000376962 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:5hXfHmHds5nuvdlFYWoB/G6nvmk9606 rogid:3VCS4B+diYoEK+/iXK6YN6Xp+2A9606 intact-crc:7855E2C9AE60650B|rigid:3igOECQSvuddozuHzQmwxuBVNPI false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P54578 uniprotkb:P28074 intact:EBI-1048016|uniprotkb:Q53XY5|uniprotkb:B7Z4N8|uniprotkb:J3QRZ5|ensembl:ENSP00000261601 intact:EBI-357828|uniprotkb:Q16242|uniprotkb:Q6PEW2|intact:EBI-1237472|uniprotkb:Q7Z3B5|uniprotkb:Q9TNN9|uniprotkb:B2R4N9|uniprotkb:D3DS43|uniprotkb:B4DUM9|uniprotkb:Q86T01|uniprotkb:E9PAV2|ensembl:ENSP00000355325 psi-mi:ubp14_human(display_long)|uniprotkb:USP14(gene name)|psi-mi:USP14(display_short)|uniprotkb:TGT(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 14(gene name synonym)|uniprotkb:Deubiquitinating enzyme 14(gene name synonym)|uniprotkb:Ubiquitin thioesterase 14(gene name synonym) psi-mi:psb5_human(display_long)|uniprotkb:PSMB5(gene name)|psi-mi:PSMB5(display_short)|uniprotkb:LMPX(gene name synonym)|uniprotkb:Proteasome epsilon chain(gene name synonym)|uniprotkb:Macropain epsilon chain(gene name synonym)|uniprotkb:Multicatalytic endopeptidase complex epsilon chain(gene name synonym)|uniprotkb:Proteasome subunit X(gene name synonym)|uniprotkb:Proteasome chain 6(gene name synonym)|uniprotkb:Proteasome subunit MB1(gene name synonym)|uniprotkb:MB1(gene name synonym)|uniprotkb:X(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511607|imex:IM-12079-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032411.1|refseq:NP_005142.1|ensembl:ENSG00000101557(gene)|ensembl:ENST00000261601(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0050920"(regulation of chemotaxis)|go:"GO:0045087"(innate immune response)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903070"(negative regulation of ER-associated ubiquitin-dependent protein catabolic process)|interpro:IPR000626(Ubiquitin)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR019954|interpro:IPR028889|interpro:IPR029071|interpro:IPR038765|interpro:IPR044635|mint:P54578|rcsb pdb:2AYN|rcsb pdb:2AYO|rcsb pdb:5GJQ|rcsb pdb:6IIK|rcsb pdb:6IIL|rcsb pdb:6IIM|rcsb pdb:6IIN|rcsb pdb:6LVS|reactome:R-HSA-5689880|go:"GO:0070628"(proteasome binding) refseq:NP_001124197.1|refseq:NP_001138404.1|refseq:NP_002788.1|dip:DIP-27540N|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|reactome:R-HSA-5610785|rcsb pdb:6KWY|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6R70|rcsb pdb:6REY|rcsb pdb:6RGQ|rcsb pdb:6WJD|rcsb pdb:6WJN|rcsb pdb:6XMJ|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|ensembl:ENSG00000100804(gene)|ensembl:ENST00000361611(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004298"(threonine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005839"(proteasome core complex)|go:"GO:0006508"(proteolysis)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008233"(peptidase activity)|go:"GO:0010499"(proteasomal ubiquitin-independent protein catabolic process)|go:"GO:0019774"(proteasome core complex, beta-subunit complex)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000243(Peptidase T1A, proteasome beta-subunit)|interpro:IPR001353(20S proteasome, A and B subunits)|interpro:IPR016050(Proteasome, beta-type subunit, conserved site)|interpro:IPR023333|interpro:IPR029055|interpro:IPR037558|mint:P28074|rcsb pdb:4R3O|rcsb pdb:4R67|rcsb pdb:5A0Q|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4G|rcsb pdb:5L5W|rcsb pdb:5L5X|rcsb pdb:5L5Y|rcsb pdb:5L5Z|rcsb pdb:5L60|rcsb pdb:5L61|rcsb pdb:5L62|rcsb pdb:5L63|rcsb pdb:5L64|rcsb pdb:5LE5|rcsb pdb:5LEX|rcsb pdb:5LEY|rcsb pdb:5LEZ|rcsb pdb:5LF0|rcsb pdb:5LF1|rcsb pdb:5LF3|rcsb pdb:5LF4|rcsb pdb:5LF6|rcsb pdb:5LF7|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFO|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:5hXfHmHds5nuvdlFYWoB/G6nvmk9606 rogid:73T59wniLri/465F3BhBvwL1/LM9606 intact-crc:7855E2C9AE60650B|rigid:3igOECQSvuddozuHzQmwxuBVNPI false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P54578 uniprotkb:P48556 intact:EBI-1048016|uniprotkb:Q53XY5|uniprotkb:B7Z4N8|uniprotkb:J3QRZ5|ensembl:ENSP00000261601 intact:EBI-359304|uniprotkb:Q6P1L7|uniprotkb:B4DX18|ensembl:ENSP00000215071|ensembl:ENSP00000481136 psi-mi:ubp14_human(display_long)|uniprotkb:USP14(gene name)|psi-mi:USP14(display_short)|uniprotkb:TGT(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 14(gene name synonym)|uniprotkb:Deubiquitinating enzyme 14(gene name synonym)|uniprotkb:Ubiquitin thioesterase 14(gene name synonym) psi-mi:psmd8_human(display_long)|uniprotkb:PSMD8(gene name)|psi-mi:PSMD8(display_short)|uniprotkb:26S proteasome regulatory subunit S14(gene name synonym)|uniprotkb:p31(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN12(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511607|imex:IM-12079-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032411.1|refseq:NP_005142.1|ensembl:ENSG00000101557(gene)|ensembl:ENST00000261601(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0050920"(regulation of chemotaxis)|go:"GO:0045087"(innate immune response)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903070"(negative regulation of ER-associated ubiquitin-dependent protein catabolic process)|interpro:IPR000626(Ubiquitin)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR019954|interpro:IPR028889|interpro:IPR029071|interpro:IPR038765|interpro:IPR044635|mint:P54578|rcsb pdb:2AYN|rcsb pdb:2AYO|rcsb pdb:5GJQ|rcsb pdb:6IIK|rcsb pdb:6IIL|rcsb pdb:6IIM|rcsb pdb:6IIN|rcsb pdb:6LVS|reactome:R-HSA-5689880|go:"GO:0070628"(proteasome binding) refseq:NP_002803.2|ensembl:ENSG00000099341(gene)|ensembl:ENST00000215071(transcript)|ensembl:ENST00000620216(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0008541"(proteasome regulatory particle, lid subcomplex)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR006746(26S proteasome non-ATPase regulatory subunit Rpn12)|interpro:IPR033464|mint:P48556|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5M32|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VGZ|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHS|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|reactome:R-HSA-180534 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:5hXfHmHds5nuvdlFYWoB/G6nvmk9606 rogid:73qmlkzCwdeHlNzUy7vy7qmIok09606 intact-crc:7855E2C9AE60650B|rigid:3igOECQSvuddozuHzQmwxuBVNPI false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P54578 uniprotkb:P35998 intact:EBI-1048016|uniprotkb:Q53XY5|uniprotkb:B7Z4N8|uniprotkb:J3QRZ5|ensembl:ENSP00000261601 intact:EBI-359710|uniprotkb:B7Z5E2|uniprotkb:A4D0Q1|uniprotkb:Q3LIA5|uniprotkb:Q9UDI3|ensembl:ENSP00000292644|ensembl:ENSP00000391211|ensembl:ENSP00000502939|ensembl:ENSP00000503179|ensembl:ENSP00000504608 psi-mi:ubp14_human(display_long)|uniprotkb:USP14(gene name)|psi-mi:USP14(display_short)|uniprotkb:TGT(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 14(gene name synonym)|uniprotkb:Deubiquitinating enzyme 14(gene name synonym)|uniprotkb:Ubiquitin thioesterase 14(gene name synonym) psi-mi:prs7_human(display_long)|uniprotkb:PSMC2(gene name)|psi-mi:PSMC2(display_short)|uniprotkb:MSS1(gene name synonym)|uniprotkb:Proteasome 26S subunit ATPase 2(gene name synonym)|uniprotkb:Protein MSS1(gene name synonym)|uniprotkb:26S proteasome AAA-ATPase subunit RPT1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511607|imex:IM-12079-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032411.1|refseq:NP_005142.1|ensembl:ENSG00000101557(gene)|ensembl:ENST00000261601(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0050920"(regulation of chemotaxis)|go:"GO:0045087"(innate immune response)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903070"(negative regulation of ER-associated ubiquitin-dependent protein catabolic process)|interpro:IPR000626(Ubiquitin)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR019954|interpro:IPR028889|interpro:IPR029071|interpro:IPR038765|interpro:IPR044635|mint:P54578|rcsb pdb:2AYN|rcsb pdb:2AYO|rcsb pdb:5GJQ|rcsb pdb:6IIK|rcsb pdb:6IIL|rcsb pdb:6IIM|rcsb pdb:6IIN|rcsb pdb:6LVS|reactome:R-HSA-5689880|go:"GO:0070628"(proteasome binding) refseq:NP_001191382.1|refseq:NP_002794.1|interpro:IPR005937(26S proteasome subunit P45)|interpro:IPR027417|interpro:IPR035245|interpro:IPR041569|mint:P35998|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4G|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|interpro:IPR003960(AAA ATPase, conserved site)|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VGZ|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHJ|rcsb pdb:5VHM|rcsb pdb:5VHN|rcsb pdb:5VHO|rcsb pdb:5VHP|ensembl:ENSG00000161057(gene)|ensembl:ENST00000292644(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|ensembl:ENST00000435765(transcript)|ensembl:ENST00000678493(transcript)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0016020"(membrane)|ensembl:ENST00000679205(transcript)|ensembl:ENST00000679341(transcript)|go:"GO:0017025"(TBP-class protein binding)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0036402"(proteasome-activating activity)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0000502"(proteasome complex)|go:"GO:0000932"(P-body)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0043197"(dendritic spine)|go:"GO:0045899"(positive regulation of RNA polymerase II transcription preinitiation complex assembly)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|rcsb pdb:5VHR|rcsb pdb:5VHS|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|rcsb pdb:5VHQ|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|reactome:R-HSA-5610780|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|dip:DIP-27554N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:5hXfHmHds5nuvdlFYWoB/G6nvmk9606 rogid:ahQfjPKywP5DWNq3FB5XCjuqkJ09606 intact-crc:7855E2C9AE60650B|rigid:3igOECQSvuddozuHzQmwxuBVNPI false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P54578 uniprotkb:P17980 intact:EBI-1048016|uniprotkb:Q53XY5|uniprotkb:B7Z4N8|uniprotkb:J3QRZ5|ensembl:ENSP00000261601 intact:EBI-359720|uniprotkb:Q3B757|ensembl:ENSP00000298852|ensembl:ENSP00000481029|uniprotkb:Q3B865|uniprotkb:Q53HU5|uniprotkb:Q6GPG8|uniprotkb:Q6IBS1|uniprotkb:Q96HD3|uniprotkb:B2R8V1 psi-mi:ubp14_human(display_long)|uniprotkb:USP14(gene name)|psi-mi:USP14(display_short)|uniprotkb:TGT(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 14(gene name synonym)|uniprotkb:Deubiquitinating enzyme 14(gene name synonym)|uniprotkb:Ubiquitin thioesterase 14(gene name synonym) psi-mi:prs6a_human(display_long)|uniprotkb:PSMC3(gene name)|psi-mi:PSMC3(display_short)|uniprotkb:TBP1(gene name synonym)|uniprotkb:Proteasome 26S subunit ATPase 3(gene name synonym)|uniprotkb:Tat-binding protein 1(gene name synonym)|uniprotkb:Proteasome subunit P50(gene name synonym)|uniprotkb:26S proteasome AAA-ATPase subunit RPT5(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511607|imex:IM-12079-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032411.1|refseq:NP_005142.1|ensembl:ENSG00000101557(gene)|ensembl:ENST00000261601(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0050920"(regulation of chemotaxis)|go:"GO:0045087"(innate immune response)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903070"(negative regulation of ER-associated ubiquitin-dependent protein catabolic process)|interpro:IPR000626(Ubiquitin)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR019954|interpro:IPR028889|interpro:IPR029071|interpro:IPR038765|interpro:IPR044635|mint:P54578|rcsb pdb:2AYN|rcsb pdb:2AYO|rcsb pdb:5GJQ|rcsb pdb:6IIK|rcsb pdb:6IIL|rcsb pdb:6IIM|rcsb pdb:6IIN|rcsb pdb:6LVS|reactome:R-HSA-5689880|go:"GO:0070628"(proteasome binding) refseq:NP_002795.2|ensembl:ENSG00000165916(gene)|ensembl:ENST00000298852(transcript)|ensembl:ENST00000619920(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0000932"(P-body)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0030163"(protein catabolic process)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042802"(identical protein binding)|go:"GO:0043921"(modulation by host of viral transcription)|go:"GO:0045899"(positive regulation of RNA polymerase II transcription preinitiation complex assembly)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR005937(26S proteasome subunit P45)|interpro:IPR027417|interpro:IPR032501|interpro:IPR035254|interpro:IPR041569|mint:P17980|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4G|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VGZ|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHJ|rcsb pdb:5VHM|rcsb pdb:5VHN|rcsb pdb:5VHO|rcsb pdb:5VHP|rcsb pdb:5VHQ|rcsb pdb:5VHR|rcsb pdb:5VHS|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6WJD|rcsb pdb:6WJN|go:"GO:0036402"(proteasome-activating activity)|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-1236978|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|dip:DIP-27555N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:5hXfHmHds5nuvdlFYWoB/G6nvmk9606 rogid:CejeauChmqeXNwBYF2cPz7mgMuw9606 intact-crc:7855E2C9AE60650B|rigid:3igOECQSvuddozuHzQmwxuBVNPI false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P54578 uniprotkb:P55036 intact:EBI-1048016|uniprotkb:Q53XY5|uniprotkb:B7Z4N8|uniprotkb:J3QRZ5|ensembl:ENSP00000261601 intact:EBI-359318|uniprotkb:Q5VWC5|uniprotkb:Q9NS92|uniprotkb:D3DV16|ensembl:ENSP00000357879 psi-mi:ubp14_human(display_long)|uniprotkb:USP14(gene name)|psi-mi:USP14(display_short)|uniprotkb:TGT(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 14(gene name synonym)|uniprotkb:Deubiquitinating enzyme 14(gene name synonym)|uniprotkb:Ubiquitin thioesterase 14(gene name synonym) psi-mi:psmd4_human(display_long)|uniprotkb:PSMD4(gene name)|psi-mi:PSMD4(display_short)|uniprotkb:MCB1(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S5A(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN10(gene name synonym)|uniprotkb:Multiubiquitin chain-binding protein(gene name synonym)|uniprotkb:Antisecretory factor 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511607|imex:IM-12079-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032411.1|refseq:NP_005142.1|ensembl:ENSG00000101557(gene)|ensembl:ENST00000261601(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0050920"(regulation of chemotaxis)|go:"GO:0045087"(innate immune response)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903070"(negative regulation of ER-associated ubiquitin-dependent protein catabolic process)|interpro:IPR000626(Ubiquitin)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR019954|interpro:IPR028889|interpro:IPR029071|interpro:IPR038765|interpro:IPR044635|mint:P54578|rcsb pdb:2AYN|rcsb pdb:2AYO|rcsb pdb:5GJQ|rcsb pdb:6IIK|rcsb pdb:6IIL|rcsb pdb:6IIM|rcsb pdb:6IIN|rcsb pdb:6LVS|reactome:R-HSA-5689880|go:"GO:0070628"(proteasome binding) refseq:NP_002801.1|dip:DIP-38189N|ensembl:ENSG00000159352(gene)|ensembl:ENST00000368884(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043248"(proteasome assembly)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR036465|mint:P55036|rcsb pdb:1P9C|rcsb pdb:1P9D|rcsb pdb:1UEL|rcsb pdb:1YX4|rcsb pdb:1YX5|rcsb pdb:1YX6|rcsb pdb:2KDE|rcsb pdb:2KDF|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VGZ|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHS|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6MUN|rcsb pdb:6U19|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:5hXfHmHds5nuvdlFYWoB/G6nvmk9606 rogid:FTJG3ns3Ag/Y3xP3yEydGxppRcA9606 intact-crc:7855E2C9AE60650B|rigid:3igOECQSvuddozuHzQmwxuBVNPI false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P54578 uniprotkb:P62191 intact:EBI-1048016|uniprotkb:Q53XY5|uniprotkb:B7Z4N8|uniprotkb:J3QRZ5|ensembl:ENSP00000261601 intact:EBI-357598|uniprotkb:P49014|uniprotkb:Q03527|uniprotkb:Q6IAW0|uniprotkb:Q96AZ3|ensembl:ENSP00000261303|uniprotkb:Q6NW36|uniprotkb:B4DR63 psi-mi:ubp14_human(display_long)|uniprotkb:USP14(gene name)|psi-mi:USP14(display_short)|uniprotkb:TGT(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 14(gene name synonym)|uniprotkb:Deubiquitinating enzyme 14(gene name synonym)|uniprotkb:Ubiquitin thioesterase 14(gene name synonym) psi-mi:prs4_human(display_long)|uniprotkb:PSMC1(gene name)|psi-mi:PSMC1(display_short)|uniprotkb:26S proteasome AAA-ATPase subunit RPT2(gene name synonym)|uniprotkb:Proteasome 26S subunit ATPase 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511607|imex:IM-12079-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032411.1|refseq:NP_005142.1|ensembl:ENSG00000101557(gene)|ensembl:ENST00000261601(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0050920"(regulation of chemotaxis)|go:"GO:0045087"(innate immune response)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903070"(negative regulation of ER-associated ubiquitin-dependent protein catabolic process)|interpro:IPR000626(Ubiquitin)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR019954|interpro:IPR028889|interpro:IPR029071|interpro:IPR038765|interpro:IPR044635|mint:P54578|rcsb pdb:2AYN|rcsb pdb:2AYO|rcsb pdb:5GJQ|rcsb pdb:6IIK|rcsb pdb:6IIL|rcsb pdb:6IIM|rcsb pdb:6IIN|rcsb pdb:6LVS|reactome:R-HSA-5689880|go:"GO:0070628"(proteasome binding) refseq:NP_002793.2|ensembl:ENST00000261303(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0017025"(TBP-class protein binding)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0030163"(protein catabolic process)|ensembl:ENSG00000100764(gene)|go:"GO:0036402"(proteasome-activating activity)|go:"GO:1901215"(negative regulation of neuron death)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR005937(26S proteasome subunit P45)|interpro:IPR027417|interpro:IPR032501|interpro:IPR035244|interpro:IPR041569|mint:P62191|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4G|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFQ|rcsb pdb:5VFU|rcsb pdb:5VGZ|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHJ|rcsb pdb:5VHM|rcsb pdb:5VHN|rcsb pdb:5VHO|rcsb pdb:5VHP|rcsb pdb:5VHQ|rcsb pdb:5VHR|rcsb pdb:5VHS|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-532668|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-8852276|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|refseq:NP_001317141.1|refseq:XP_016876959.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:5hXfHmHds5nuvdlFYWoB/G6nvmk9606 rogid:oGEtU7Cv0qversbD3WQgAo5H9pM9606 intact-crc:7855E2C9AE60650B|rigid:3igOECQSvuddozuHzQmwxuBVNPI false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P54578 uniprotkb:Q9Y5M8 intact:EBI-1048016|uniprotkb:Q53XY5|uniprotkb:B7Z4N8|uniprotkb:J3QRZ5|ensembl:ENSP00000261601 intact:EBI-355393|uniprotkb:Q8N2D8|uniprotkb:Q6P595|ensembl:ENSP00000418401|ensembl:ENSP00000503923 psi-mi:ubp14_human(display_long)|uniprotkb:USP14(gene name)|psi-mi:USP14(display_short)|uniprotkb:TGT(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 14(gene name synonym)|uniprotkb:Deubiquitinating enzyme 14(gene name synonym)|uniprotkb:Ubiquitin thioesterase 14(gene name synonym) psi-mi:srprb_human(display_long)|uniprotkb:SRPRB(gene name)|psi-mi:SRPRB(display_short)|uniprotkb:PSEC0230(orf name)|uniprotkb:Protein APMCF1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511607|imex:IM-12079-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032411.1|refseq:NP_005142.1|ensembl:ENSG00000101557(gene)|ensembl:ENST00000261601(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0050920"(regulation of chemotaxis)|go:"GO:0045087"(innate immune response)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903070"(negative regulation of ER-associated ubiquitin-dependent protein catabolic process)|interpro:IPR000626(Ubiquitin)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR019954|interpro:IPR028889|interpro:IPR029071|interpro:IPR038765|interpro:IPR044635|mint:P54578|rcsb pdb:2AYN|rcsb pdb:2AYO|rcsb pdb:5GJQ|rcsb pdb:6IIK|rcsb pdb:6IIL|rcsb pdb:6IIM|rcsb pdb:6IIN|rcsb pdb:6LVS|reactome:R-HSA-5689880|go:"GO:0070628"(proteasome binding) refseq:NP_067026.3|ensembl:ENSG00000144867(gene)|ensembl:ENST00000466490(transcript)|ensembl:ENST00000678299(transcript)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005785"(signal recognition particle receptor complex)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0045047"(protein targeting to ER)|interpro:IPR019009|interpro:IPR027417|mint:Q9Y5M8|rcsb pdb:7NFX|reactome:R-HSA-1799339|reactome:R-HSA-381038|dip:DIP-50218N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:5hXfHmHds5nuvdlFYWoB/G6nvmk9606 rogid:pHUdnCvOhMRYIJg//OJ+SlCard49606 intact-crc:7855E2C9AE60650B|rigid:3igOECQSvuddozuHzQmwxuBVNPI false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P54578 uniprotkb:Q13200 intact:EBI-1048016|uniprotkb:Q53XY5|uniprotkb:B7Z4N8|uniprotkb:J3QRZ5|ensembl:ENSP00000261601 intact:EBI-357648|uniprotkb:B4DX07|uniprotkb:B4DXY1|uniprotkb:E7EW34|uniprotkb:E9PCS3|uniprotkb:Q12932|uniprotkb:Q15321|uniprotkb:Q96I12|ensembl:ENSP00000310129|uniprotkb:Q53XQ4 psi-mi:ubp14_human(display_long)|uniprotkb:USP14(gene name)|psi-mi:USP14(display_short)|uniprotkb:TGT(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 14(gene name synonym)|uniprotkb:Deubiquitinating enzyme 14(gene name synonym)|uniprotkb:Ubiquitin thioesterase 14(gene name synonym) psi-mi:psmd2_human(display_long)|uniprotkb:PSMD2(gene name)|psi-mi:PSMD2(display_short)|uniprotkb:TRAP2(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN1(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S2(gene name synonym)|uniprotkb:26S proteasome subunit p97(gene name synonym)|uniprotkb:Tumor necrosis factor type 1 receptor-associated protein 2(gene name synonym)|uniprotkb:Protein 55.11(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511607|imex:IM-12079-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032411.1|refseq:NP_005142.1|ensembl:ENSG00000101557(gene)|ensembl:ENST00000261601(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0050920"(regulation of chemotaxis)|go:"GO:0045087"(innate immune response)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903070"(negative regulation of ER-associated ubiquitin-dependent protein catabolic process)|interpro:IPR000626(Ubiquitin)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR019954|interpro:IPR028889|interpro:IPR029071|interpro:IPR038765|interpro:IPR044635|mint:P54578|rcsb pdb:2AYN|rcsb pdb:2AYO|rcsb pdb:5GJQ|rcsb pdb:6IIK|rcsb pdb:6IIL|rcsb pdb:6IIM|rcsb pdb:6IIN|rcsb pdb:6LVS|reactome:R-HSA-5689880|go:"GO:0070628"(proteasome binding) refseq:NP_001265637.1|refseq:NP_001265638.1|refseq:NP_002799.3|ensembl:ENSG00000175166(gene)|ensembl:ENST00000310118(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0008540"(proteasome regulatory particle, base subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0034515"(proteasome storage granule)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR002015(Proteasome/cyclosome, regulatory subunit)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040892|interpro:IPR041433|mint:Q13200|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|interpro:IPR016643(26S proteasome regulatory complex, non-ATPase subcomplex, Rpn1 subunit)|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHJ|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|reactome:R-HSA-9010553|rcsb pdb:5VHM|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:5VHN|rcsb pdb:5VHO|rcsb pdb:5VHP|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:5VHQ|rcsb pdb:5VHR|rcsb pdb:5VHS|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|rcsb pdb:6MSB|rcsb pdb:6MSD|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-5668541|dip:DIP-38204N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:5hXfHmHds5nuvdlFYWoB/G6nvmk9606 rogid:wujS1i4Gs3gWNinOey4oKsshA+g9606 intact-crc:7855E2C9AE60650B|rigid:3igOECQSvuddozuHzQmwxuBVNPI false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P54578 uniprotkb:O00231 intact:EBI-1048016|uniprotkb:Q53XY5|uniprotkb:B7Z4N8|uniprotkb:J3QRZ5|ensembl:ENSP00000261601 intact:EBI-357816|uniprotkb:O00495|uniprotkb:A8K3I7|uniprotkb:E1P663|uniprotkb:Q53FT5|ensembl:ENSP00000261712|ensembl:ENSP00000393185|ensembl:ENSP00000497128 psi-mi:ubp14_human(display_long)|uniprotkb:USP14(gene name)|psi-mi:USP14(display_short)|uniprotkb:TGT(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 14(gene name synonym)|uniprotkb:Deubiquitinating enzyme 14(gene name synonym)|uniprotkb:Ubiquitin thioesterase 14(gene name synonym) psi-mi:psd11_human(display_long)|uniprotkb:PSMD11(gene name)|psi-mi:PSMD11(display_short)|uniprotkb:26S proteasome regulatory subunit S9(gene name synonym)|uniprotkb:26S proteasome regulatory subunit p44.5(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN6(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511607|imex:IM-12079-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032411.1|refseq:NP_005142.1|ensembl:ENSG00000101557(gene)|ensembl:ENST00000261601(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0050920"(regulation of chemotaxis)|go:"GO:0045087"(innate immune response)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903070"(negative regulation of ER-associated ubiquitin-dependent protein catabolic process)|interpro:IPR000626(Ubiquitin)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR019954|interpro:IPR028889|interpro:IPR029071|interpro:IPR038765|interpro:IPR044635|mint:P54578|rcsb pdb:2AYN|rcsb pdb:2AYO|rcsb pdb:5GJQ|rcsb pdb:6IIK|rcsb pdb:6IIL|rcsb pdb:6IIM|rcsb pdb:6IIN|rcsb pdb:6LVS|reactome:R-HSA-5689880|go:"GO:0070628"(proteasome binding) refseq:NP_002806.2|refseq:NP_001257411.1|ensembl:ENSG00000108671(gene)|ensembl:ENST00000261712(transcript)|ensembl:ENST00000457654(transcript)|ensembl:ENST00000649012(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008541"(proteasome regulatory particle, lid subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0043248"(proteasome assembly)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR035295|interpro:IPR036390|interpro:IPR040773|interpro:IPR040780|mint:O00231|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5M32|rcsb pdb:5LN3|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VGZ|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHS|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:5hXfHmHds5nuvdlFYWoB/G6nvmk9606 rogid:BgQKXK7gMMihacRCI+g/pBnRN309606 intact-crc:7855E2C9AE60650B|rigid:3igOECQSvuddozuHzQmwxuBVNPI false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P54578 uniprotkb:O75832 intact:EBI-1048016|uniprotkb:Q53XY5|uniprotkb:B7Z4N8|uniprotkb:J3QRZ5|ensembl:ENSP00000261601 intact:EBI-752185|uniprotkb:Q8IZK9|uniprotkb:Q5U0B2|ensembl:ENSP00000217958 psi-mi:ubp14_human(display_long)|uniprotkb:USP14(gene name)|psi-mi:USP14(display_short)|uniprotkb:TGT(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 14(gene name synonym)|uniprotkb:Deubiquitinating enzyme 14(gene name synonym)|uniprotkb:Ubiquitin thioesterase 14(gene name synonym) psi-mi:psd10_human(display_long)|uniprotkb:26S proteasome regulatory subunit p28(gene name synonym)|uniprotkb:Gankyrin(gene name synonym)|uniprotkb:PSMD10(gene name)|psi-mi:PSMD10(display_short)|uniprotkb:"p28(GANK)"(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511607|imex:IM-12079-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032411.1|refseq:NP_005142.1|ensembl:ENSG00000101557(gene)|ensembl:ENST00000261601(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0050920"(regulation of chemotaxis)|go:"GO:0045087"(innate immune response)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903070"(negative regulation of ER-associated ubiquitin-dependent protein catabolic process)|interpro:IPR000626(Ubiquitin)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR019954|interpro:IPR028889|interpro:IPR029071|interpro:IPR038765|interpro:IPR044635|mint:P54578|rcsb pdb:2AYN|rcsb pdb:2AYO|rcsb pdb:5GJQ|rcsb pdb:6IIK|rcsb pdb:6IIL|rcsb pdb:6IIM|rcsb pdb:6IIN|rcsb pdb:6LVS|reactome:R-HSA-5689880|go:"GO:0070628"(proteasome binding) refseq:NP_002805.1|refseq:NP_736606.1|dip:DIP-39026N|ensembl:ENSG00000101843(gene)|ensembl:ENST00000217958(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000502"(proteasome complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0008134"(transcription factor binding)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0043518"(negative regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0070682"(proteasome regulatory particle assembly)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR036770|go:"GO:0007253"(cytoplasmic sequestering of NF-kappaB)|mint:O75832|rcsb pdb:1QYM|rcsb pdb:1TR4|rcsb pdb:1UOH|rcsb pdb:4NIK|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHJ|rcsb pdb:5VHM|rcsb pdb:5VHN|rcsb pdb:5VHO|rcsb pdb:5VHP|rcsb pdb:5VHQ|rcsb pdb:5VHR|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|interpro:IPR039334|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|reactome:R-HSA-8951664 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:5hXfHmHds5nuvdlFYWoB/G6nvmk9606 rogid:HJ1dl0tNhvWH7pSVWKpadkqe8A09606 intact-crc:7855E2C9AE60650B|rigid:3igOECQSvuddozuHzQmwxuBVNPI false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P54578 uniprotkb:P60900 intact:EBI-1048016|uniprotkb:Q53XY5|uniprotkb:B7Z4N8|uniprotkb:J3QRZ5|ensembl:ENSP00000261601 intact:EBI-357793|uniprotkb:P34062|uniprotkb:Q6IB60|uniprotkb:B2R7J9|uniprotkb:B4DQR4|uniprotkb:B4DXJ9|ensembl:ENSP00000261479 psi-mi:ubp14_human(display_long)|uniprotkb:USP14(gene name)|psi-mi:USP14(display_short)|uniprotkb:TGT(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 14(gene name synonym)|uniprotkb:Deubiquitinating enzyme 14(gene name synonym)|uniprotkb:Ubiquitin thioesterase 14(gene name synonym) psi-mi:psa6_human(display_long)|uniprotkb:PSMA6(gene name)|psi-mi:PSMA6(display_short)|uniprotkb:PROS27(gene name synonym)|uniprotkb:Proteasome iota chain(gene name synonym)|uniprotkb:Macropain iota chain(gene name synonym)|uniprotkb:Multicatalytic endopeptidase complex iota chain(gene name synonym)|uniprotkb:27 kDa prosomal protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511607|imex:IM-12079-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032411.1|refseq:NP_005142.1|ensembl:ENSG00000101557(gene)|ensembl:ENST00000261601(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0050920"(regulation of chemotaxis)|go:"GO:0045087"(innate immune response)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903070"(negative regulation of ER-associated ubiquitin-dependent protein catabolic process)|interpro:IPR000626(Ubiquitin)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR019954|interpro:IPR028889|interpro:IPR029071|interpro:IPR038765|interpro:IPR044635|mint:P54578|rcsb pdb:2AYN|rcsb pdb:2AYO|rcsb pdb:5GJQ|rcsb pdb:6IIK|rcsb pdb:6IIL|rcsb pdb:6IIM|rcsb pdb:6IIN|rcsb pdb:6LVS|reactome:R-HSA-5689880|go:"GO:0070628"(proteasome binding) refseq:NP_002782.1|refseq:NP_001269162.1|refseq:NP_001269163.1|refseq:XP_016876957.1|refseq:NP_001269161.1|ensembl:ENSG00000100902(gene)|ensembl:ENST00000261479(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0000932"(P-body)|go:"GO:0003723"(RNA binding)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005839"(proteasome core complex)|go:"GO:0005844"(polysome)|go:"GO:0010499"(proteasomal ubiquitin-independent protein catabolic process)|go:"GO:0016363"(nuclear matrix)|go:"GO:0019773"(proteasome core complex, alpha-subunit complex)|go:"GO:0030016"(myofibril)|go:"GO:0030017"(sarcomere)|go:"GO:0035639"(purine ribonucleoside triphosphate binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000426(Proteasome alpha-subunit, conserved site)|interpro:IPR001353(20S proteasome, A and B subunits)|interpro:IPR023332|interpro:IPR029055|interpro:IPR034642|mint:P60900|rcsb pdb:4R3O|rcsb pdb:4R67|rcsb pdb:5A0Q|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4G|rcsb pdb:5LE5|rcsb pdb:5LEX|rcsb pdb:5LEY|rcsb pdb:5LEZ|rcsb pdb:5LF0|rcsb pdb:5LF1|rcsb pdb:5LF3|rcsb pdb:5LF4|rcsb pdb:5LF6|rcsb pdb:5LF7|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFO|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:6AVO|rcsb pdb:6E5B|rcsb pdb:6KWY|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSK|rcsb pdb:6R70|rcsb pdb:6REY|rcsb pdb:6RGQ|rcsb pdb:6WJD|rcsb pdb:6WJN|rcsb pdb:6XMJ|rcsb pdb:7AWE|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|dip:DIP-29367N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:5hXfHmHds5nuvdlFYWoB/G6nvmk9606 rogid:F+Kwr6rnDS3jD53gBGHDIn7HV/89606 intact-crc:7855E2C9AE60650B|rigid:3igOECQSvuddozuHzQmwxuBVNPI false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P54578 uniprotkb:Q16186 intact:EBI-1048016|uniprotkb:Q53XY5|uniprotkb:B7Z4N8|uniprotkb:J3QRZ5|ensembl:ENSP00000261601 intact:EBI-954387|ensembl:ENSP00000253003|ensembl:ENSP00000478877|uniprotkb:A0PKB1|uniprotkb:Q96FJ7|uniprotkb:Q9H1P2 psi-mi:ubp14_human(display_long)|uniprotkb:USP14(gene name)|psi-mi:USP14(display_short)|uniprotkb:TGT(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 14(gene name synonym)|uniprotkb:Deubiquitinating enzyme 14(gene name synonym)|uniprotkb:Ubiquitin thioesterase 14(gene name synonym) psi-mi:adrm1_human(display_long)|uniprotkb:Adhesion-regulating molecule 1(gene name synonym)|uniprotkb:110 kDa cell membrane glycoprotein(gene name synonym)|uniprotkb:Rpn13 homolog(gene name synonym)|uniprotkb:Proteasome regulatory particle non-ATPase 13(gene name synonym)|uniprotkb:ADRM1(gene name)|psi-mi:ADRM1(display_short)|uniprotkb:GP110(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511607|imex:IM-12079-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032411.1|refseq:NP_005142.1|ensembl:ENSG00000101557(gene)|ensembl:ENST00000261601(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0050920"(regulation of chemotaxis)|go:"GO:0045087"(innate immune response)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903070"(negative regulation of ER-associated ubiquitin-dependent protein catabolic process)|interpro:IPR000626(Ubiquitin)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR019954|interpro:IPR028889|interpro:IPR029071|interpro:IPR038765|interpro:IPR044635|mint:P54578|rcsb pdb:2AYN|rcsb pdb:2AYO|rcsb pdb:5GJQ|rcsb pdb:6IIK|rcsb pdb:6IIL|rcsb pdb:6IIM|rcsb pdb:6IIN|rcsb pdb:6LVS|reactome:R-HSA-5689880|go:"GO:0070628"(proteasome binding) ensembl:ENSG00000130706(gene)|ensembl:ENST00000253003(transcript)|ensembl:ENST00000491935(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0002020"(protease binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008541"(proteasome regulatory particle, lid subcomplex)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043248"(proteasome assembly)|go:"GO:0061133"(endopeptidase activator activity)|go:"GO:0070628"(proteasome binding)|interpro:IPR006773(Adhesion regulating molecule)|interpro:IPR032368|interpro:IPR038108|interpro:IPR038633|interpro:IPR044867|interpro:IPR044868|mint:Q16186|rcsb pdb:2KQZ|rcsb pdb:2KR0|rcsb pdb:2L5V|rcsb pdb:2MKZ|rcsb pdb:2NBV|rcsb pdb:4UEL|rcsb pdb:4UEM|rcsb pdb:4WLQ|rcsb pdb:4WLR|rcsb pdb:5IRS|rcsb pdb:5V1Y|rcsb pdb:5V1Z|rcsb pdb:5YMY|rcsb pdb:6CO4|rcsb pdb:6OI4|rcsb pdb:6UYJ|reactome:R-HSA-5689603|reactome:R-HSA-5689880|rcsb pdb:6UYI|refseq:NP_008933.2|refseq:NP_783163.1|refseq:NP_001268366.1|refseq:NP_001268367.1|refseq:XP_005260314.1|dip:DIP-42668N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:5hXfHmHds5nuvdlFYWoB/G6nvmk9606 rogid:XrSLNnNr5Ojm0HkgcnnPube5Lno9606 intact-crc:7855E2C9AE60650B|rigid:3igOECQSvuddozuHzQmwxuBVNPI false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P54578 uniprotkb:O43396 intact:EBI-1048016|uniprotkb:Q53XY5|uniprotkb:B7Z4N8|uniprotkb:J3QRZ5|ensembl:ENSP00000261601 intact:EBI-1048857|ensembl:ENSP00000217515|ensembl:ENSP00000464918 psi-mi:ubp14_human(display_long)|uniprotkb:USP14(gene name)|psi-mi:USP14(display_short)|uniprotkb:TGT(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 14(gene name synonym)|uniprotkb:Deubiquitinating enzyme 14(gene name synonym)|uniprotkb:Ubiquitin thioesterase 14(gene name synonym) psi-mi:txnl1_human(display_long)|uniprotkb:32 kDa thioredoxin-related protein(gene name synonym)|uniprotkb:TXNL1(gene name)|psi-mi:TXNL1(display_short)|uniprotkb:TRP32(gene name synonym)|uniprotkb:TXL(gene name synonym)|uniprotkb:TXNL(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511607|imex:IM-12079-17 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001032411.1|refseq:NP_005142.1|ensembl:ENSG00000101557(gene)|ensembl:ENST00000261601(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0050920"(regulation of chemotaxis)|go:"GO:0045087"(innate immune response)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903070"(negative regulation of ER-associated ubiquitin-dependent protein catabolic process)|interpro:IPR000626(Ubiquitin)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR019954|interpro:IPR028889|interpro:IPR029071|interpro:IPR038765|interpro:IPR044635|mint:P54578|rcsb pdb:2AYN|rcsb pdb:2AYO|rcsb pdb:5GJQ|rcsb pdb:6IIK|rcsb pdb:6IIL|rcsb pdb:6IIM|rcsb pdb:6IIN|rcsb pdb:6LVS|reactome:R-HSA-5689880|go:"GO:0070628"(proteasome binding) refseq:NP_004777.1|ensembl:ENSG00000091164(gene)|ensembl:ENST00000217515(transcript)|ensembl:ENST00000590954(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0015036"(disulfide oxidoreductase activity)|interpro:IPR008979(Galactose-binding like)|interpro:IPR010400(Protein of unknown function DUF1000)|interpro:IPR013766(Thioredoxin domain)|interpro:IPR017937|interpro:IPR036249|interpro:IPR037047|mint:O43396|rcsb pdb:1GH2|rcsb pdb:1WWY|reactome:R-HSA-9013418|reactome:R-HSA-9013420|reactome:R-HSA-9013422|reactome:R-HSA-9013424|reactome:R-HSA-9696264|reactome:R-HSA-9696270|reactome:R-HSA-9696273|refseq:XP_016881582.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:5hXfHmHds5nuvdlFYWoB/G6nvmk9606 rogid:v3qpLTWgZZ1f4Tz/ixVYlSPv7Ro9606 intact-crc:7855E2C9AE60650B|rigid:3igOECQSvuddozuHzQmwxuBVNPI false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y4E8 uniprotkb:Q05048 intact:EBI-1043104|uniprotkb:Q9HCA6|uniprotkb:Q9UNP0|uniprotkb:Q9Y5B5|ensembl:ENSP00000280377|uniprotkb:Q9H8G9|uniprotkb:Q08AL5 intact:EBI-1789619|uniprotkb:Q5QPD8|ensembl:ENSP00000217109 psi-mi:ubp15_human(display_long)|uniprotkb:Unph4(gene name synonym)|uniprotkb:USP15(gene name)|psi-mi:USP15(display_short)|uniprotkb:KIAA0529(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 15(gene name synonym)|uniprotkb:Deubiquitinating enzyme 15(gene name synonym)|uniprotkb:Unph-2(gene name synonym)|uniprotkb:Ubiquitin thioesterase 15(gene name synonym) psi-mi:cstf1_human(display_long)|uniprotkb:CSTF1(gene name)|psi-mi:CSTF1(display_short)|uniprotkb:CF-1 50 kDa subunit(gene name synonym)|uniprotkb:Cleavage stimulation factor 50 kDa subunit(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511673|imex:IM-12079-68 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000135655(gene)|ensembl:ENST00000280377(transcript)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0035520"(monoubiquitinated protein deubiquitination)|go:"GO:0035616"(histone H2B conserved C-terminal lysine deubiquitination)|go:"GO:0042802"(identical protein binding)|go:"GO:0046332"(SMAD binding)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0061649"(ubiquitin modification-dependent histone binding)|go:"GO:1900246"(positive regulation of RIG-I signaling pathway)|go:"GO:1905035"(negative regulation of antifungal innate immune response)|go:"GO:1990167"(protein K27-linked deubiquitination)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR013792(RNA 3'-terminal phosphate cyclase/enolpyruvate transferase, alpha/beta)|interpro:IPR018200|interpro:IPR028135|interpro:IPR028889|interpro:IPR029071|interpro:IPR029346|interpro:IPR035927|interpro:IPR038765|mint:Q9Y4E8|rcsb pdb:1W6V|rcsb pdb:3LMN|rcsb pdb:3PPA|rcsb pdb:3PV1|rcsb pdb:3T9L|rcsb pdb:4A3O|rcsb pdb:4A3P|rcsb pdb:5JJW|rcsb pdb:6CPM|rcsb pdb:6CRN|rcsb pdb:6DJ9|rcsb pdb:6GH9|rcsb pdb:6GHA|rcsb pdb:6ML1|reactome:R-HSA-2173788|reactome:R-HSA-5689603|reactome:R-HSA-5689880|refseq:NP_006304.1|refseq:NP_001239008.1|refseq:NP_001239007.1|dip:DIP-50239N refseq:XP_011526902.1|refseq:NP_001028693.1|refseq:NP_001028694.1|refseq:NP_001315.1|ensembl:ENSG00000101138(gene)|ensembl:ENST00000217109(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005848"(mRNA cleavage stimulating factor complex)|go:"GO:0031124"(mRNA 3'-end processing)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR032028|interpro:IPR036322|interpro:IPR038184|interpro:IPR044633|mint:Q05048|rcsb pdb:6B3X|reactome:R-HSA-72163|reactome:R-HSA-72187|reactome:R-HSA-73856|reactome:R-HSA-77595 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/09/18 rogid:Hjx7D3Eq+fTpjE3D3fUujJN9gW89606 rogid:p1WA38/ygDg6E9lsofH6JH8wU7k9606 intact-crc:19BCF0F4A4AEA314|rigid:Z97f0uMdr+tC4vLZ/fcqtuDrCQg false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y4E8 uniprotkb:P0DPA2 intact:EBI-1043104|uniprotkb:Q9HCA6|uniprotkb:Q9UNP0|uniprotkb:Q9Y5B5|ensembl:ENSP00000280377|uniprotkb:Q9H8G9|uniprotkb:Q08AL5 intact:EBI-2511675|ensembl:ENSP00000357080|uniprotkb:Q5VU13|uniprotkb:Q5VU14 psi-mi:ubp15_human(display_long)|uniprotkb:Unph4(gene name synonym)|uniprotkb:USP15(gene name)|psi-mi:USP15(display_short)|uniprotkb:KIAA0529(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 15(gene name synonym)|uniprotkb:Deubiquitinating enzyme 15(gene name synonym)|uniprotkb:Unph-2(gene name synonym)|uniprotkb:Ubiquitin thioesterase 15(gene name synonym) psi-mi:vsig8_human(display_long)|uniprotkb:VSIG8(gene name)|psi-mi:VSIG8(display_short)|uniprotkb:C1orf204(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511673|imex:IM-12079-68 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000135655(gene)|ensembl:ENST00000280377(transcript)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0035520"(monoubiquitinated protein deubiquitination)|go:"GO:0035616"(histone H2B conserved C-terminal lysine deubiquitination)|go:"GO:0042802"(identical protein binding)|go:"GO:0046332"(SMAD binding)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0061649"(ubiquitin modification-dependent histone binding)|go:"GO:1900246"(positive regulation of RIG-I signaling pathway)|go:"GO:1905035"(negative regulation of antifungal innate immune response)|go:"GO:1990167"(protein K27-linked deubiquitination)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR013792(RNA 3'-terminal phosphate cyclase/enolpyruvate transferase, alpha/beta)|interpro:IPR018200|interpro:IPR028135|interpro:IPR028889|interpro:IPR029071|interpro:IPR029346|interpro:IPR035927|interpro:IPR038765|mint:Q9Y4E8|rcsb pdb:1W6V|rcsb pdb:3LMN|rcsb pdb:3PPA|rcsb pdb:3PV1|rcsb pdb:3T9L|rcsb pdb:4A3O|rcsb pdb:4A3P|rcsb pdb:5JJW|rcsb pdb:6CPM|rcsb pdb:6CRN|rcsb pdb:6DJ9|rcsb pdb:6GH9|rcsb pdb:6GHA|rcsb pdb:6ML1|reactome:R-HSA-2173788|reactome:R-HSA-5689603|reactome:R-HSA-5689880|refseq:NP_006304.1|refseq:NP_001239008.1|refseq:NP_001239007.1|dip:DIP-50239N ensembl:ENSG00000243284(gene)|ensembl:ENST00000368100(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0016021"(integral component of membrane)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|refseq:NP_001013683.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/09/18 rogid:Hjx7D3Eq+fTpjE3D3fUujJN9gW89606 rogid:G9zPlqv7Eli5zS2I59AMvpfhKek9606 intact-crc:19BCF0F4A4AEA314|rigid:Z97f0uMdr+tC4vLZ/fcqtuDrCQg false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y4E8 uniprotkb:Q13228 intact:EBI-1043104|uniprotkb:Q9HCA6|uniprotkb:Q9UNP0|uniprotkb:Q9Y5B5|ensembl:ENSP00000280377|uniprotkb:Q9H8G9|uniprotkb:Q08AL5 intact:EBI-711619|uniprotkb:A6NML9|uniprotkb:A6PVW9|uniprotkb:B2RDR3|uniprotkb:Q96GX7|uniprotkb:B4DKP6|uniprotkb:Q49AQ8|uniprotkb:B4E1F3|ensembl:ENSP00000357861 psi-mi:ubp15_human(display_long)|uniprotkb:Unph4(gene name synonym)|uniprotkb:USP15(gene name)|psi-mi:USP15(display_short)|uniprotkb:KIAA0529(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 15(gene name synonym)|uniprotkb:Deubiquitinating enzyme 15(gene name synonym)|uniprotkb:Unph-2(gene name synonym)|uniprotkb:Ubiquitin thioesterase 15(gene name synonym) psi-mi:sbp1_human(display_long)|uniprotkb:SELENBP1(gene name)|psi-mi:SELENBP1(display_short)|uniprotkb:SBP(gene name synonym)|uniprotkb:56 kDa selenium-binding protein(gene name synonym)|uniprotkb:Selenium-binding protein 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511673|imex:IM-12079-68 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000135655(gene)|ensembl:ENST00000280377(transcript)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0035520"(monoubiquitinated protein deubiquitination)|go:"GO:0035616"(histone H2B conserved C-terminal lysine deubiquitination)|go:"GO:0042802"(identical protein binding)|go:"GO:0046332"(SMAD binding)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0061649"(ubiquitin modification-dependent histone binding)|go:"GO:1900246"(positive regulation of RIG-I signaling pathway)|go:"GO:1905035"(negative regulation of antifungal innate immune response)|go:"GO:1990167"(protein K27-linked deubiquitination)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR013792(RNA 3'-terminal phosphate cyclase/enolpyruvate transferase, alpha/beta)|interpro:IPR018200|interpro:IPR028135|interpro:IPR028889|interpro:IPR029071|interpro:IPR029346|interpro:IPR035927|interpro:IPR038765|mint:Q9Y4E8|rcsb pdb:1W6V|rcsb pdb:3LMN|rcsb pdb:3PPA|rcsb pdb:3PV1|rcsb pdb:3T9L|rcsb pdb:4A3O|rcsb pdb:4A3P|rcsb pdb:5JJW|rcsb pdb:6CPM|rcsb pdb:6CRN|rcsb pdb:6DJ9|rcsb pdb:6GH9|rcsb pdb:6GHA|rcsb pdb:6ML1|reactome:R-HSA-2173788|reactome:R-HSA-5689603|reactome:R-HSA-5689880|refseq:NP_006304.1|refseq:NP_001239008.1|refseq:NP_001239007.1|dip:DIP-50239N refseq:NP_003935.2|refseq:NP_001245218.1|refseq:NP_001245217.1|ensembl:ENSG00000143416(gene)|ensembl:ENST00000368868(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0005615"(extracellular space)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0008430"(selenium binding)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0018549"(methanethiol oxidase activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR008826(Selenium-binding protein) psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/09/18 rogid:Hjx7D3Eq+fTpjE3D3fUujJN9gW89606 rogid:PqHTrxV3+3S/4C428UI+2jl6omo9606 intact-crc:19BCF0F4A4AEA314|rigid:Z97f0uMdr+tC4vLZ/fcqtuDrCQg false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y4E8 uniprotkb:O95777 intact:EBI-1043104|uniprotkb:Q9HCA6|uniprotkb:Q9UNP0|uniprotkb:Q9Y5B5|ensembl:ENSP00000280377|uniprotkb:Q9H8G9|uniprotkb:Q08AL5 intact:EBI-347779|ensembl:ENSP00000249299 psi-mi:ubp15_human(display_long)|uniprotkb:Unph4(gene name synonym)|uniprotkb:USP15(gene name)|psi-mi:USP15(display_short)|uniprotkb:KIAA0529(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 15(gene name synonym)|uniprotkb:Deubiquitinating enzyme 15(gene name synonym)|uniprotkb:Unph-2(gene name synonym)|uniprotkb:Ubiquitin thioesterase 15(gene name synonym) psi-mi:lsm8_human(display_long)|uniprotkb:LSM8(gene name)|psi-mi:LSM8(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511673|imex:IM-12079-68 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000135655(gene)|ensembl:ENST00000280377(transcript)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0035520"(monoubiquitinated protein deubiquitination)|go:"GO:0035616"(histone H2B conserved C-terminal lysine deubiquitination)|go:"GO:0042802"(identical protein binding)|go:"GO:0046332"(SMAD binding)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0061649"(ubiquitin modification-dependent histone binding)|go:"GO:1900246"(positive regulation of RIG-I signaling pathway)|go:"GO:1905035"(negative regulation of antifungal innate immune response)|go:"GO:1990167"(protein K27-linked deubiquitination)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR013792(RNA 3'-terminal phosphate cyclase/enolpyruvate transferase, alpha/beta)|interpro:IPR018200|interpro:IPR028135|interpro:IPR028889|interpro:IPR029071|interpro:IPR029346|interpro:IPR035927|interpro:IPR038765|mint:Q9Y4E8|rcsb pdb:1W6V|rcsb pdb:3LMN|rcsb pdb:3PPA|rcsb pdb:3PV1|rcsb pdb:3T9L|rcsb pdb:4A3O|rcsb pdb:4A3P|rcsb pdb:5JJW|rcsb pdb:6CPM|rcsb pdb:6CRN|rcsb pdb:6DJ9|rcsb pdb:6GH9|rcsb pdb:6GHA|rcsb pdb:6ML1|reactome:R-HSA-2173788|reactome:R-HSA-5689603|reactome:R-HSA-5689880|refseq:NP_006304.1|refseq:NP_001239008.1|refseq:NP_001239007.1|dip:DIP-50239N refseq:NP_057284.1|dip:DIP-31195N|ensembl:ENSG00000128534(gene)|ensembl:ENST00000249299(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005688"(U6 snRNP)|go:"GO:0016070"(RNA metabolic process)|go:"GO:0017070"(U6 snRNA binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071011"(precatalytic spliceosome)|go:"GO:0120115"(Lsm2-8 complex)|interpro:IPR001163(Like-Sm ribonucleoprotein, core)|interpro:IPR010920(Like-Sm ribonucleoprotein-related, core)|interpro:IPR034103|interpro:IPR044642|rcsb pdb:3JCR|rcsb pdb:5O9Z|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6QW6|rcsb pdb:6QX9|rcsb pdb:7ABG|reactome:R-HSA-72163 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/09/18 rogid:Hjx7D3Eq+fTpjE3D3fUujJN9gW89606 rogid:Kyf8IAEIkbe1s2NnqxqGA1o6BbU9606 intact-crc:19BCF0F4A4AEA314|rigid:Z97f0uMdr+tC4vLZ/fcqtuDrCQg false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y4E8 uniprotkb:P47929 intact:EBI-1043104|uniprotkb:Q9HCA6|uniprotkb:Q9UNP0|uniprotkb:Q9Y5B5|ensembl:ENSP00000280377|uniprotkb:Q9H8G9|uniprotkb:Q08AL5 intact:EBI-357504|ensembl:ENSP00000313571|ensembl:ENSP00000367891|ensembl:ENSP00000489395|ensembl:ENSP00000489582|uniprotkb:Q6IB87 psi-mi:ubp15_human(display_long)|uniprotkb:Unph4(gene name synonym)|uniprotkb:USP15(gene name)|psi-mi:USP15(display_short)|uniprotkb:KIAA0529(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 15(gene name synonym)|uniprotkb:Deubiquitinating enzyme 15(gene name synonym)|uniprotkb:Unph-2(gene name synonym)|uniprotkb:Ubiquitin thioesterase 15(gene name synonym) psi-mi:leg7_human(display_long)|uniprotkb:LGALS7(gene name)|psi-mi:LGALS7(display_short)|uniprotkb:PIG1(gene name synonym)|uniprotkb:HKL-14(gene name synonym)|uniprotkb:PI7(gene name synonym)|uniprotkb:p53-induced gene 1 protein(gene name synonym)|uniprotkb:LGALS7B(gene name)|psi-mi:LGALS7B(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511673|imex:IM-12079-68 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000135655(gene)|ensembl:ENST00000280377(transcript)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0035520"(monoubiquitinated protein deubiquitination)|go:"GO:0035616"(histone H2B conserved C-terminal lysine deubiquitination)|go:"GO:0042802"(identical protein binding)|go:"GO:0046332"(SMAD binding)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0061649"(ubiquitin modification-dependent histone binding)|go:"GO:1900246"(positive regulation of RIG-I signaling pathway)|go:"GO:1905035"(negative regulation of antifungal innate immune response)|go:"GO:1990167"(protein K27-linked deubiquitination)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR013792(RNA 3'-terminal phosphate cyclase/enolpyruvate transferase, alpha/beta)|interpro:IPR018200|interpro:IPR028135|interpro:IPR028889|interpro:IPR029071|interpro:IPR029346|interpro:IPR035927|interpro:IPR038765|mint:Q9Y4E8|rcsb pdb:1W6V|rcsb pdb:3LMN|rcsb pdb:3PPA|rcsb pdb:3PV1|rcsb pdb:3T9L|rcsb pdb:4A3O|rcsb pdb:4A3P|rcsb pdb:5JJW|rcsb pdb:6CPM|rcsb pdb:6CRN|rcsb pdb:6DJ9|rcsb pdb:6GH9|rcsb pdb:6GHA|rcsb pdb:6ML1|reactome:R-HSA-2173788|reactome:R-HSA-5689603|reactome:R-HSA-5689880|refseq:NP_006304.1|refseq:NP_001239008.1|refseq:NP_001239007.1|dip:DIP-50239N ensembl:ENSG00000178934(gene)|ensembl:ENSG00000205076(gene)|ensembl:ENSG00000282902(gene)|ensembl:ENSG00000283082(gene)|ensembl:ENST00000314980(transcript)|ensembl:ENST00000378626(transcript)|ensembl:ENST00000634448(transcript)|ensembl:ENST00000634800(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016936"(galactoside binding)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0070062"(extracellular exosome)|go:"GO:2000562"(negative regulation of CD4-positive, alpha-beta T cell proliferation)|interpro:IPR001079(Galectin, galactose-binding lectin)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR030640|interpro:IPR044156|mint:P47929|rcsb pdb:1BKZ|rcsb pdb:2GAL|rcsb pdb:3GAL|rcsb pdb:3ZXE|rcsb pdb:3ZXF|rcsb pdb:4GAL|rcsb pdb:4UW3|rcsb pdb:4UW4|rcsb pdb:4UW5|rcsb pdb:4UW6|rcsb pdb:4XBQ|rcsb pdb:4Y26|rcsb pdb:5GAL|rcsb pdb:5H9Q|rcsb pdb:5H9S|refseq:NP_001035972.1|refseq:NP_002298.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/09/18 rogid:Hjx7D3Eq+fTpjE3D3fUujJN9gW89606 rogid:TIAlvVZ7rOYqTAGrYAFbJY231gc9606 intact-crc:19BCF0F4A4AEA314|rigid:Z97f0uMdr+tC4vLZ/fcqtuDrCQg false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y4E8 uniprotkb:Q8WWY3 intact:EBI-1043104|uniprotkb:Q9HCA6|uniprotkb:Q9UNP0|uniprotkb:Q9Y5B5|ensembl:ENSP00000280377|uniprotkb:Q9H8G9|uniprotkb:Q08AL5 intact:EBI-1567797|uniprotkb:Q8N7F9|uniprotkb:Q9H271|uniprotkb:Q9Y439|uniprotkb:Q17RB4|intact:EBI-10177194|uniprotkb:F1T0A5|uniprotkb:E7ESA8|uniprotkb:F1T0A4|ensembl:ENSP00000324122|ensembl:ENSP00000483929 psi-mi:ubp15_human(display_long)|uniprotkb:Unph4(gene name synonym)|uniprotkb:USP15(gene name)|psi-mi:USP15(display_short)|uniprotkb:KIAA0529(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 15(gene name synonym)|uniprotkb:Deubiquitinating enzyme 15(gene name synonym)|uniprotkb:Unph-2(gene name synonym)|uniprotkb:Ubiquitin thioesterase 15(gene name synonym) psi-mi:prp31_human(display_long)|uniprotkb:Pre-mRNA-processing factor 31(gene name synonym)|uniprotkb:U4/U6 snRNP 61 kDa protein(gene name synonym)|uniprotkb:Serologically defined breast cancer antigen NY-BR-99(gene name synonym)|uniprotkb:PRPF31(gene name)|psi-mi:PRPF31(display_short)|uniprotkb:PRP31(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511673|imex:IM-12079-68 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000135655(gene)|ensembl:ENST00000280377(transcript)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0035520"(monoubiquitinated protein deubiquitination)|go:"GO:0035616"(histone H2B conserved C-terminal lysine deubiquitination)|go:"GO:0042802"(identical protein binding)|go:"GO:0046332"(SMAD binding)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0061649"(ubiquitin modification-dependent histone binding)|go:"GO:1900246"(positive regulation of RIG-I signaling pathway)|go:"GO:1905035"(negative regulation of antifungal innate immune response)|go:"GO:1990167"(protein K27-linked deubiquitination)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR013792(RNA 3'-terminal phosphate cyclase/enolpyruvate transferase, alpha/beta)|interpro:IPR018200|interpro:IPR028135|interpro:IPR028889|interpro:IPR029071|interpro:IPR029346|interpro:IPR035927|interpro:IPR038765|mint:Q9Y4E8|rcsb pdb:1W6V|rcsb pdb:3LMN|rcsb pdb:3PPA|rcsb pdb:3PV1|rcsb pdb:3T9L|rcsb pdb:4A3O|rcsb pdb:4A3P|rcsb pdb:5JJW|rcsb pdb:6CPM|rcsb pdb:6CRN|rcsb pdb:6DJ9|rcsb pdb:6GH9|rcsb pdb:6GHA|rcsb pdb:6ML1|reactome:R-HSA-2173788|reactome:R-HSA-5689603|reactome:R-HSA-5689880|refseq:NP_006304.1|refseq:NP_001239008.1|refseq:NP_001239007.1|dip:DIP-50239N refseq:XP_006723200.1|refseq:NP_056444.3|ensembl:ENSG00000105618(gene)|ensembl:ENSG00000275885(gene)|ensembl:ENST00000321030(transcript)|ensembl:ENST00000613693(transcript)|go:"GO:0000244"(spliceosomal tri-snRNP complex assembly)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005684"(U2-type spliceosomal complex)|go:"GO:0071339"(MLL1 complex)|go:"GO:0097526"(spliceosomal tri-snRNP complex)|go:"GO:0005687"(U4 snRNP)|go:"GO:0005690"(U4atac snRNP)|go:"GO:0015030"(Cajal body)|go:"GO:0016607"(nuclear speck)|interpro:IPR002687(Pre-mRNA processing ribonucleoprotein, binding region)|go:"GO:0030621"(U4 snRNA binding)|go:"GO:0030622"(U4atac snRNA binding)|go:"GO:0042802"(identical protein binding)|interpro:IPR012976(NOSIC)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0070990"(snRNP binding)|interpro:IPR019175|interpro:IPR027105|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071011"(precatalytic spliceosome)|go:"GO:0071166"(ribonucleoprotein complex localization)|interpro:IPR036070|interpro:IPR042239|mint:Q8WWY3|rcsb pdb:2OZB|rcsb pdb:3JCR|rcsb pdb:3SIU|rcsb pdb:3SIV|rcsb pdb:5O9Z|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6QW6|rcsb pdb:6QX9|reactome:R-HSA-72163 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/09/18 rogid:Hjx7D3Eq+fTpjE3D3fUujJN9gW89606 rogid:NsXY3tY7Y2EEK8rxoisqlfpzuf89606 intact-crc:19BCF0F4A4AEA314|rigid:Z97f0uMdr+tC4vLZ/fcqtuDrCQg false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y4E8 uniprotkb:P30566 intact:EBI-1043104|uniprotkb:Q9HCA6|uniprotkb:Q9UNP0|uniprotkb:Q9Y5B5|ensembl:ENSP00000280377|uniprotkb:Q9H8G9|uniprotkb:Q08AL5 intact:EBI-2511688|ensembl:ENSP00000485525|uniprotkb:B0QY76|uniprotkb:O75495|uniprotkb:Q5TI34 psi-mi:ubp15_human(display_long)|uniprotkb:Unph4(gene name synonym)|uniprotkb:USP15(gene name)|psi-mi:USP15(display_short)|uniprotkb:KIAA0529(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 15(gene name synonym)|uniprotkb:Deubiquitinating enzyme 15(gene name synonym)|uniprotkb:Unph-2(gene name synonym)|uniprotkb:Ubiquitin thioesterase 15(gene name synonym) psi-mi:pur8_human(display_long)|uniprotkb:ADSL(gene name)|psi-mi:ADSL(display_short)|uniprotkb:AMPS(gene name synonym)|uniprotkb:Adenylosuccinase(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511673|imex:IM-12079-68 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000135655(gene)|ensembl:ENST00000280377(transcript)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0035520"(monoubiquitinated protein deubiquitination)|go:"GO:0035616"(histone H2B conserved C-terminal lysine deubiquitination)|go:"GO:0042802"(identical protein binding)|go:"GO:0046332"(SMAD binding)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0061649"(ubiquitin modification-dependent histone binding)|go:"GO:1900246"(positive regulation of RIG-I signaling pathway)|go:"GO:1905035"(negative regulation of antifungal innate immune response)|go:"GO:1990167"(protein K27-linked deubiquitination)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR013792(RNA 3'-terminal phosphate cyclase/enolpyruvate transferase, alpha/beta)|interpro:IPR018200|interpro:IPR028135|interpro:IPR028889|interpro:IPR029071|interpro:IPR029346|interpro:IPR035927|interpro:IPR038765|mint:Q9Y4E8|rcsb pdb:1W6V|rcsb pdb:3LMN|rcsb pdb:3PPA|rcsb pdb:3PV1|rcsb pdb:3T9L|rcsb pdb:4A3O|rcsb pdb:4A3P|rcsb pdb:5JJW|rcsb pdb:6CPM|rcsb pdb:6CRN|rcsb pdb:6DJ9|rcsb pdb:6GH9|rcsb pdb:6GHA|rcsb pdb:6ML1|reactome:R-HSA-2173788|reactome:R-HSA-5689603|reactome:R-HSA-5689880|refseq:NP_006304.1|refseq:NP_001239008.1|refseq:NP_001239007.1|dip:DIP-50239N go:"GO:0014850"(response to muscle activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042594"(response to starvation)|go:"GO:0042802"(identical protein binding)|go:"GO:0044208"('de novo' AMP biosynthetic process)|go:"GO:0070626"("(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity")|ensembl:ENSG00000239900(gene)|ensembl:ENST00000623063(transcript)|interpro:IPR000362(Fumarate lyase)|interpro:IPR004769(Adenylosuccinate lyase)|interpro:IPR008948(L-Aspartase-like)|interpro:IPR019468|interpro:IPR020557|interpro:IPR022761|rcsb pdb:2J91|rcsb pdb:2VD6|rcsb pdb:4FFX|rcsb pdb:4FLC|reactome:R-HSA-73817|go:"GO:0001666"(response to hypoxia)|go:"GO:0004018"("N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity")|go:"GO:0005829"(cytosol)|go:"GO:0006164"(purine nucleotide biosynthetic process)|go:"GO:0006167"(AMP biosynthetic process)|go:"GO:0006189"('de novo' IMP biosynthetic process)|go:"GO:0007584"(response to nutrient)|go:"GO:0009060"(aerobic respiration)|refseq:NP_000017.1|refseq:NP_001116850.1|refseq:NP_001304852.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/09/18 rogid:Hjx7D3Eq+fTpjE3D3fUujJN9gW89606 rogid:yBhDdHJgZN1NJDpN2ivKLI4oUG09606 intact-crc:19BCF0F4A4AEA314|rigid:Z97f0uMdr+tC4vLZ/fcqtuDrCQg false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y4E8 uniprotkb:P12277 intact:EBI-1043104|uniprotkb:Q9HCA6|uniprotkb:Q9UNP0|uniprotkb:Q9Y5B5|ensembl:ENSP00000280377|uniprotkb:Q9H8G9|uniprotkb:Q08AL5 intact:EBI-357706|uniprotkb:Q2LE07|uniprotkb:A8K236|uniprotkb:B2R5R4|uniprotkb:Q6FG40|uniprotkb:Q9UC66|ensembl:ENSP00000299198 psi-mi:ubp15_human(display_long)|uniprotkb:Unph4(gene name synonym)|uniprotkb:USP15(gene name)|psi-mi:USP15(display_short)|uniprotkb:KIAA0529(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 15(gene name synonym)|uniprotkb:Deubiquitinating enzyme 15(gene name synonym)|uniprotkb:Unph-2(gene name synonym)|uniprotkb:Ubiquitin thioesterase 15(gene name synonym) psi-mi:kcrb_human(display_long)|uniprotkb:CKB(gene name)|psi-mi:CKB(display_short)|uniprotkb:CKBB(gene name synonym)|uniprotkb:Creatine kinase B chain(gene name synonym)|uniprotkb:Brain creatine kinase(gene name synonym)|uniprotkb:Creatine phosphokinase B-type(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511673|imex:IM-12079-68 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000135655(gene)|ensembl:ENST00000280377(transcript)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0035520"(monoubiquitinated protein deubiquitination)|go:"GO:0035616"(histone H2B conserved C-terminal lysine deubiquitination)|go:"GO:0042802"(identical protein binding)|go:"GO:0046332"(SMAD binding)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0061649"(ubiquitin modification-dependent histone binding)|go:"GO:1900246"(positive regulation of RIG-I signaling pathway)|go:"GO:1905035"(negative regulation of antifungal innate immune response)|go:"GO:1990167"(protein K27-linked deubiquitination)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR013792(RNA 3'-terminal phosphate cyclase/enolpyruvate transferase, alpha/beta)|interpro:IPR018200|interpro:IPR028135|interpro:IPR028889|interpro:IPR029071|interpro:IPR029346|interpro:IPR035927|interpro:IPR038765|mint:Q9Y4E8|rcsb pdb:1W6V|rcsb pdb:3LMN|rcsb pdb:3PPA|rcsb pdb:3PV1|rcsb pdb:3T9L|rcsb pdb:4A3O|rcsb pdb:4A3P|rcsb pdb:5JJW|rcsb pdb:6CPM|rcsb pdb:6CRN|rcsb pdb:6DJ9|rcsb pdb:6GH9|rcsb pdb:6GHA|rcsb pdb:6ML1|reactome:R-HSA-2173788|reactome:R-HSA-5689603|reactome:R-HSA-5689880|refseq:NP_006304.1|refseq:NP_001239008.1|refseq:NP_001239007.1|dip:DIP-50239N refseq:NP_001814.2|go:"GO:0005829"(cytosol)|ensembl:ENSG00000166165(gene)|ensembl:ENST00000348956(transcript)|go:"GO:0004111"(creatine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0016301"(kinase activity)|go:"GO:0021549"(cerebellum development)|interpro:IPR022413|interpro:IPR022414|interpro:IPR022415|interpro:IPR036802|mint:P12277|rcsb pdb:3B6R|rcsb pdb:3DRB|rcsb pdb:3DRE|rcsb pdb:6V9H|go:"GO:0021762"(substantia nigra development)|go:"GO:0030425"(dendrite)|go:"GO:0030644"(cellular chloride ion homeostasis)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0046314"(phosphocreatine biosynthetic process)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000749("ATP:guanido phosphotransferase")|interpro:IPR014746(Glutamine synthetase/guanido kinase, catalytic region)|reactome:R-HSA-71288|reactome:R-HSA-9696264|dip:DIP-52968N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/09/18 rogid:Hjx7D3Eq+fTpjE3D3fUujJN9gW89606 rogid:WLRnU8sRUfJQoaPY0edGi9xiR+g9606 intact-crc:19BCF0F4A4AEA314|rigid:Z97f0uMdr+tC4vLZ/fcqtuDrCQg false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y4E8 uniprotkb:O76011 intact:EBI-1043104|uniprotkb:Q9HCA6|uniprotkb:Q9UNP0|uniprotkb:Q9Y5B5|ensembl:ENSP00000280377|uniprotkb:Q9H8G9|uniprotkb:Q08AL5 intact:EBI-1047093|uniprotkb:Q8IUT8|uniprotkb:Q8N4W2|ensembl:ENSP00000377570 psi-mi:ubp15_human(display_long)|uniprotkb:Unph4(gene name synonym)|uniprotkb:USP15(gene name)|psi-mi:USP15(display_short)|uniprotkb:KIAA0529(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 15(gene name synonym)|uniprotkb:Deubiquitinating enzyme 15(gene name synonym)|uniprotkb:Unph-2(gene name synonym)|uniprotkb:Ubiquitin thioesterase 15(gene name synonym) psi-mi:krt34_human(display_long)|uniprotkb:KRTHA4(gene name synonym)|uniprotkb:Hair keratin, type I Ha4(gene name synonym)|uniprotkb:Keratin-34(gene name synonym)|uniprotkb:HKA4(gene name synonym)|uniprotkb:KRT34(gene name)|psi-mi:KRT34(display_short)|uniprotkb:HHA4(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511673|imex:IM-12079-68 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000135655(gene)|ensembl:ENST00000280377(transcript)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0035520"(monoubiquitinated protein deubiquitination)|go:"GO:0035616"(histone H2B conserved C-terminal lysine deubiquitination)|go:"GO:0042802"(identical protein binding)|go:"GO:0046332"(SMAD binding)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0061649"(ubiquitin modification-dependent histone binding)|go:"GO:1900246"(positive regulation of RIG-I signaling pathway)|go:"GO:1905035"(negative regulation of antifungal innate immune response)|go:"GO:1990167"(protein K27-linked deubiquitination)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR013792(RNA 3'-terminal phosphate cyclase/enolpyruvate transferase, alpha/beta)|interpro:IPR018200|interpro:IPR028135|interpro:IPR028889|interpro:IPR029071|interpro:IPR029346|interpro:IPR035927|interpro:IPR038765|mint:Q9Y4E8|rcsb pdb:1W6V|rcsb pdb:3LMN|rcsb pdb:3PPA|rcsb pdb:3PV1|rcsb pdb:3T9L|rcsb pdb:4A3O|rcsb pdb:4A3P|rcsb pdb:5JJW|rcsb pdb:6CPM|rcsb pdb:6CRN|rcsb pdb:6DJ9|rcsb pdb:6GH9|rcsb pdb:6GHA|rcsb pdb:6ML1|reactome:R-HSA-2173788|reactome:R-HSA-5689603|reactome:R-HSA-5689880|refseq:NP_006304.1|refseq:NP_001239008.1|refseq:NP_001239007.1|dip:DIP-50239N refseq:NP_066293.2|refseq:XP_003403930.1|ensembl:ENSG00000131737(gene)|ensembl:ENST00000394001(transcript)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005829"(cytosol)|go:"GO:0005882"(intermediate filament)|go:"GO:0008544"(epidermis development)|interpro:IPR002957(Keratin, type I)|interpro:IPR018039|interpro:IPR039008|reactome:R-HSA-6805567|reactome:R-HSA-6809371 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/09/18 rogid:Hjx7D3Eq+fTpjE3D3fUujJN9gW89606 rogid:XZO0Izt6trxcPRSUGRwVsgJfCu09606 intact-crc:19BCF0F4A4AEA314|rigid:Z97f0uMdr+tC4vLZ/fcqtuDrCQg false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y4E8 uniprotkb:P78386 intact:EBI-1043104|uniprotkb:Q9HCA6|uniprotkb:Q9UNP0|uniprotkb:Q9Y5B5|ensembl:ENSP00000280377|uniprotkb:Q9H8G9|uniprotkb:Q08AL5 intact:EBI-1049371|uniprotkb:Q9NSB1|ensembl:ENSP00000257901 psi-mi:ubp15_human(display_long)|uniprotkb:Unph4(gene name synonym)|uniprotkb:USP15(gene name)|psi-mi:USP15(display_short)|uniprotkb:KIAA0529(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 15(gene name synonym)|uniprotkb:Deubiquitinating enzyme 15(gene name synonym)|uniprotkb:Unph-2(gene name synonym)|uniprotkb:Ubiquitin thioesterase 15(gene name synonym) psi-mi:krt85_human(display_long)|uniprotkb:Type II hair keratin Hb5(gene name synonym)|uniprotkb:Keratin-85(gene name synonym)|uniprotkb:Hair keratin K2.12(gene name synonym)|uniprotkb:KRT85(gene name)|psi-mi:KRT85(display_short)|uniprotkb:KRTHB5(gene name synonym)|uniprotkb:Type-II keratin Kb25(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511673|imex:IM-12079-68 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000135655(gene)|ensembl:ENST00000280377(transcript)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0035520"(monoubiquitinated protein deubiquitination)|go:"GO:0035616"(histone H2B conserved C-terminal lysine deubiquitination)|go:"GO:0042802"(identical protein binding)|go:"GO:0046332"(SMAD binding)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0061649"(ubiquitin modification-dependent histone binding)|go:"GO:1900246"(positive regulation of RIG-I signaling pathway)|go:"GO:1905035"(negative regulation of antifungal innate immune response)|go:"GO:1990167"(protein K27-linked deubiquitination)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR013792(RNA 3'-terminal phosphate cyclase/enolpyruvate transferase, alpha/beta)|interpro:IPR018200|interpro:IPR028135|interpro:IPR028889|interpro:IPR029071|interpro:IPR029346|interpro:IPR035927|interpro:IPR038765|mint:Q9Y4E8|rcsb pdb:1W6V|rcsb pdb:3LMN|rcsb pdb:3PPA|rcsb pdb:3PV1|rcsb pdb:3T9L|rcsb pdb:4A3O|rcsb pdb:4A3P|rcsb pdb:5JJW|rcsb pdb:6CPM|rcsb pdb:6CRN|rcsb pdb:6DJ9|rcsb pdb:6GH9|rcsb pdb:6GHA|rcsb pdb:6ML1|reactome:R-HSA-2173788|reactome:R-HSA-5689603|reactome:R-HSA-5689880|refseq:NP_006304.1|refseq:NP_001239008.1|refseq:NP_001239007.1|dip:DIP-50239N refseq:NP_001287739.1|refseq:NP_002274.1|ensembl:ENSG00000135443(gene)|ensembl:ENST00000257901(transcript)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005829"(cytosol)|go:"GO:0008544"(epidermis development)|go:"GO:0045095"(keratin filament)|interpro:IPR003054(Type II keratin)|interpro:IPR018039|interpro:IPR032444|interpro:IPR039008|reactome:R-HSA-6805567|reactome:R-HSA-6809371 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/09/18 rogid:Hjx7D3Eq+fTpjE3D3fUujJN9gW89606 rogid:O+5NoIWK84IGOos3h32HHMjZE889606 intact-crc:19BCF0F4A4AEA314|rigid:Z97f0uMdr+tC4vLZ/fcqtuDrCQg false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y4E8 uniprotkb:O43395 intact:EBI-1043104|uniprotkb:Q9HCA6|uniprotkb:Q9UNP0|uniprotkb:Q9Y5B5|ensembl:ENSP00000280377|uniprotkb:Q9H8G9|uniprotkb:Q08AL5 intact:EBI-744322|uniprotkb:O43446|uniprotkb:Q5VT54|uniprotkb:B4DSY9|intact:EBI-28983618|ensembl:ENSP00000315379 psi-mi:ubp15_human(display_long)|uniprotkb:Unph4(gene name synonym)|uniprotkb:USP15(gene name)|psi-mi:USP15(display_short)|uniprotkb:KIAA0529(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 15(gene name synonym)|uniprotkb:Deubiquitinating enzyme 15(gene name synonym)|uniprotkb:Unph-2(gene name synonym)|uniprotkb:Ubiquitin thioesterase 15(gene name synonym) psi-mi:prpf3_human(display_long)|uniprotkb:Pre-mRNA-splicing factor 3(gene name synonym)|uniprotkb:U4/U6 snRNP 90 kDa protein(gene name synonym)|uniprotkb:PRPF3(gene name)|psi-mi:PRPF3(display_short)|uniprotkb:HPRP3(gene name synonym)|uniprotkb:PRP3(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511673|imex:IM-12079-68 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000135655(gene)|ensembl:ENST00000280377(transcript)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0035520"(monoubiquitinated protein deubiquitination)|go:"GO:0035616"(histone H2B conserved C-terminal lysine deubiquitination)|go:"GO:0042802"(identical protein binding)|go:"GO:0046332"(SMAD binding)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0061649"(ubiquitin modification-dependent histone binding)|go:"GO:1900246"(positive regulation of RIG-I signaling pathway)|go:"GO:1905035"(negative regulation of antifungal innate immune response)|go:"GO:1990167"(protein K27-linked deubiquitination)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR013792(RNA 3'-terminal phosphate cyclase/enolpyruvate transferase, alpha/beta)|interpro:IPR018200|interpro:IPR028135|interpro:IPR028889|interpro:IPR029071|interpro:IPR029346|interpro:IPR035927|interpro:IPR038765|mint:Q9Y4E8|rcsb pdb:1W6V|rcsb pdb:3LMN|rcsb pdb:3PPA|rcsb pdb:3PV1|rcsb pdb:3T9L|rcsb pdb:4A3O|rcsb pdb:4A3P|rcsb pdb:5JJW|rcsb pdb:6CPM|rcsb pdb:6CRN|rcsb pdb:6DJ9|rcsb pdb:6GH9|rcsb pdb:6GHA|rcsb pdb:6ML1|reactome:R-HSA-2173788|reactome:R-HSA-5689603|reactome:R-HSA-5689880|refseq:NP_006304.1|refseq:NP_001239008.1|refseq:NP_001239007.1|dip:DIP-50239N refseq:NP_004689.1|ensembl:ENSP00000315379|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005829"(cytosol)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0015030"(Cajal body)|go:"GO:0016607"(nuclear speck)|go:"GO:0042802"(identical protein binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0071005"(U2-type precatalytic spliceosome)|interpro:IPR002483(Splicing factor PWI)|interpro:IPR010541(Protein of unknown function DUF1115)|interpro:IPR013881(Pre-mRNA-splicing factor 3)|interpro:IPR027104|interpro:IPR036483|mint:O43395|rcsb pdb:1X4Q|rcsb pdb:3JCR|rcsb pdb:5O9Z|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6QW6|rcsb pdb:6QX9|reactome:R-HSA-72163|ensembl:ENSG00000117360(gene)|ensembl:ENST00000324862(transcript)|go:"GO:0000244"(spliceosomal tri-snRNP complex assembly)|go:"GO:0000375"(RNA splicing, via transesterification reactions)|dip:DIP-34508N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/09/18 rogid:Hjx7D3Eq+fTpjE3D3fUujJN9gW89606 rogid:Y2aO1gQjTU8JERVtrLpgbXq7nLU9606 intact-crc:19BCF0F4A4AEA314|rigid:Z97f0uMdr+tC4vLZ/fcqtuDrCQg false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y4E8 uniprotkb:P15259 intact:EBI-1043104|uniprotkb:Q9HCA6|uniprotkb:Q9UNP0|uniprotkb:Q9Y5B5|ensembl:ENSP00000280377|uniprotkb:Q9H8G9|uniprotkb:Q08AL5 intact:EBI-2511669|ensembl:ENSP00000297283 psi-mi:ubp15_human(display_long)|uniprotkb:Unph4(gene name synonym)|uniprotkb:USP15(gene name)|psi-mi:USP15(display_short)|uniprotkb:KIAA0529(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 15(gene name synonym)|uniprotkb:Deubiquitinating enzyme 15(gene name synonym)|uniprotkb:Unph-2(gene name synonym)|uniprotkb:Ubiquitin thioesterase 15(gene name synonym) psi-mi:pgam2_human(display_long)|uniprotkb:PGAM2(gene name)|psi-mi:PGAM2(display_short)|uniprotkb:PGAMM(gene name synonym)|uniprotkb:Phosphoglycerate mutase isozyme M(gene name synonym)|uniprotkb:BPG-dependent PGAM 2(gene name synonym)|uniprotkb:Muscle-specific phosphoglycerate mutase(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511673|imex:IM-12079-68 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000135655(gene)|ensembl:ENST00000280377(transcript)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0035520"(monoubiquitinated protein deubiquitination)|go:"GO:0035616"(histone H2B conserved C-terminal lysine deubiquitination)|go:"GO:0042802"(identical protein binding)|go:"GO:0046332"(SMAD binding)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0061649"(ubiquitin modification-dependent histone binding)|go:"GO:1900246"(positive regulation of RIG-I signaling pathway)|go:"GO:1905035"(negative regulation of antifungal innate immune response)|go:"GO:1990167"(protein K27-linked deubiquitination)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR013792(RNA 3'-terminal phosphate cyclase/enolpyruvate transferase, alpha/beta)|interpro:IPR018200|interpro:IPR028135|interpro:IPR028889|interpro:IPR029071|interpro:IPR029346|interpro:IPR035927|interpro:IPR038765|mint:Q9Y4E8|rcsb pdb:1W6V|rcsb pdb:3LMN|rcsb pdb:3PPA|rcsb pdb:3PV1|rcsb pdb:3T9L|rcsb pdb:4A3O|rcsb pdb:4A3P|rcsb pdb:5JJW|rcsb pdb:6CPM|rcsb pdb:6CRN|rcsb pdb:6DJ9|rcsb pdb:6GH9|rcsb pdb:6GHA|rcsb pdb:6ML1|reactome:R-HSA-2173788|reactome:R-HSA-5689603|reactome:R-HSA-5689880|refseq:NP_006304.1|refseq:NP_001239008.1|refseq:NP_001239007.1|dip:DIP-50239N ensembl:ENSG00000164708(gene)|ensembl:ENST00000297283(transcript)|go:"GO:0004082"(bisphosphoglycerate mutase activity)|go:"GO:0004619"(phosphoglycerate mutase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006096"(glycolytic process)|go:"GO:0006941"(striated muscle contraction)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007283"(spermatogenesis)|go:"GO:0016787"(hydrolase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0046538"(2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity)|go:"GO:0046689"(response to mercury ion)|interpro:IPR001345(Phosphoglycerate/bisphosphoglycerate mutase)|interpro:IPR005952(Phosphoglycerate mutase 1)|interpro:IPR013078(Phosphoglycerate mutase)|interpro:IPR029033|reactome:R-HSA-70171|reactome:R-HSA-70263|go:"GO:0070062"(extracellular exosome)|refseq:NP_000281.2 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/09/18 rogid:Hjx7D3Eq+fTpjE3D3fUujJN9gW89606 rogid:vvkAsNcXn85pUpOvqy5JqF99n309606 intact-crc:19BCF0F4A4AEA314|rigid:Z97f0uMdr+tC4vLZ/fcqtuDrCQg false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y4E8 uniprotkb:Q9H6E5 intact:EBI-1043104|uniprotkb:Q9HCA6|uniprotkb:Q9UNP0|uniprotkb:Q9Y5B5|ensembl:ENSP00000280377|uniprotkb:Q9H8G9|uniprotkb:Q08AL5 intact:EBI-2511680|ensembl:ENSP00000419607|uniprotkb:Q9H6H7|uniprotkb:Q7L583|uniprotkb:Q2NL65|uniprotkb:A1A527|intact:EBI-2809257|uniprotkb:A8K995 psi-mi:ubp15_human(display_long)|uniprotkb:Unph4(gene name synonym)|uniprotkb:USP15(gene name)|psi-mi:USP15(display_short)|uniprotkb:KIAA0529(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 15(gene name synonym)|uniprotkb:Deubiquitinating enzyme 15(gene name synonym)|uniprotkb:Unph-2(gene name synonym)|uniprotkb:Ubiquitin thioesterase 15(gene name synonym) psi-mi:stpap_human(display_long)|uniprotkb:TUT1(gene name)|psi-mi:TUT1(display_short)|uniprotkb:RBM21(gene name synonym)|uniprotkb:RNA-binding motif protein 21(gene name synonym)|uniprotkb:U6 snRNA-specific terminal uridylyltransferase 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511673|imex:IM-12079-68 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000135655(gene)|ensembl:ENST00000280377(transcript)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0035520"(monoubiquitinated protein deubiquitination)|go:"GO:0035616"(histone H2B conserved C-terminal lysine deubiquitination)|go:"GO:0042802"(identical protein binding)|go:"GO:0046332"(SMAD binding)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0061649"(ubiquitin modification-dependent histone binding)|go:"GO:1900246"(positive regulation of RIG-I signaling pathway)|go:"GO:1905035"(negative regulation of antifungal innate immune response)|go:"GO:1990167"(protein K27-linked deubiquitination)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR013792(RNA 3'-terminal phosphate cyclase/enolpyruvate transferase, alpha/beta)|interpro:IPR018200|interpro:IPR028135|interpro:IPR028889|interpro:IPR029071|interpro:IPR029346|interpro:IPR035927|interpro:IPR038765|mint:Q9Y4E8|rcsb pdb:1W6V|rcsb pdb:3LMN|rcsb pdb:3PPA|rcsb pdb:3PV1|rcsb pdb:3T9L|rcsb pdb:4A3O|rcsb pdb:4A3P|rcsb pdb:5JJW|rcsb pdb:6CPM|rcsb pdb:6CRN|rcsb pdb:6DJ9|rcsb pdb:6GH9|rcsb pdb:6GHA|rcsb pdb:6ML1|reactome:R-HSA-2173788|reactome:R-HSA-5689603|reactome:R-HSA-5689880|refseq:NP_006304.1|refseq:NP_001239008.1|refseq:NP_001239007.1|dip:DIP-50239N rcsb pdb:5WU6|rcsb pdb:5WU5|ensembl:ENSG00000149016(gene)|ensembl:ENST00000476907(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0004652"(polynucleotide adenylyltransferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006378"(mRNA polyadenylation)|go:"GO:0016180"(snRNA processing)|go:"GO:0016607"(nuclear speck)|go:"GO:0016779"(nucleotidyltransferase activity)|go:"GO:0017070"(U6 snRNA binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0031123"(RNA 3'-end processing)|go:"GO:0034477"(U6 snRNA 3'-end processing)|go:"GO:0046872"(metal ion binding)|go:"GO:0050265"(RNA uridylyltransferase activity)|go:"GO:0098789"(pre-mRNA cleavage required for polyadenylation)|go:"GO:1990817"(RNA adenylyltransferase activity)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR002058(PAP/25A-associated)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034388|interpro:IPR035979|interpro:IPR036236|interpro:IPR043519|mint:Q9H6E5|rcsb pdb:2E5G|rcsb pdb:5WU1|rcsb pdb:5WU2|rcsb pdb:5WU3|rcsb pdb:5WU4|go:"GO:0005730"(nucleolus)|refseq:NP_073741.2|dip:DIP-53651N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/09/18 rogid:Hjx7D3Eq+fTpjE3D3fUujJN9gW89606 rogid:7Df5H4dyiKBTRo4xiRZGbzGvzbk9606 intact-crc:19BCF0F4A4AEA314|rigid:Z97f0uMdr+tC4vLZ/fcqtuDrCQg false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y4E8 uniprotkb:O00231 intact:EBI-1043104|uniprotkb:Q9HCA6|uniprotkb:Q9UNP0|uniprotkb:Q9Y5B5|ensembl:ENSP00000280377|uniprotkb:Q9H8G9|uniprotkb:Q08AL5 intact:EBI-357816|uniprotkb:O00495|uniprotkb:A8K3I7|uniprotkb:E1P663|uniprotkb:Q53FT5|ensembl:ENSP00000261712|ensembl:ENSP00000393185|ensembl:ENSP00000497128 psi-mi:ubp15_human(display_long)|uniprotkb:Unph4(gene name synonym)|uniprotkb:USP15(gene name)|psi-mi:USP15(display_short)|uniprotkb:KIAA0529(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 15(gene name synonym)|uniprotkb:Deubiquitinating enzyme 15(gene name synonym)|uniprotkb:Unph-2(gene name synonym)|uniprotkb:Ubiquitin thioesterase 15(gene name synonym) psi-mi:psd11_human(display_long)|uniprotkb:PSMD11(gene name)|psi-mi:PSMD11(display_short)|uniprotkb:26S proteasome regulatory subunit S9(gene name synonym)|uniprotkb:26S proteasome regulatory subunit p44.5(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN6(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511673|imex:IM-12079-68 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000135655(gene)|ensembl:ENST00000280377(transcript)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0035520"(monoubiquitinated protein deubiquitination)|go:"GO:0035616"(histone H2B conserved C-terminal lysine deubiquitination)|go:"GO:0042802"(identical protein binding)|go:"GO:0046332"(SMAD binding)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0061649"(ubiquitin modification-dependent histone binding)|go:"GO:1900246"(positive regulation of RIG-I signaling pathway)|go:"GO:1905035"(negative regulation of antifungal innate immune response)|go:"GO:1990167"(protein K27-linked deubiquitination)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR013792(RNA 3'-terminal phosphate cyclase/enolpyruvate transferase, alpha/beta)|interpro:IPR018200|interpro:IPR028135|interpro:IPR028889|interpro:IPR029071|interpro:IPR029346|interpro:IPR035927|interpro:IPR038765|mint:Q9Y4E8|rcsb pdb:1W6V|rcsb pdb:3LMN|rcsb pdb:3PPA|rcsb pdb:3PV1|rcsb pdb:3T9L|rcsb pdb:4A3O|rcsb pdb:4A3P|rcsb pdb:5JJW|rcsb pdb:6CPM|rcsb pdb:6CRN|rcsb pdb:6DJ9|rcsb pdb:6GH9|rcsb pdb:6GHA|rcsb pdb:6ML1|reactome:R-HSA-2173788|reactome:R-HSA-5689603|reactome:R-HSA-5689880|refseq:NP_006304.1|refseq:NP_001239008.1|refseq:NP_001239007.1|dip:DIP-50239N refseq:NP_002806.2|refseq:NP_001257411.1|ensembl:ENSG00000108671(gene)|ensembl:ENST00000261712(transcript)|ensembl:ENST00000457654(transcript)|ensembl:ENST00000649012(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008541"(proteasome regulatory particle, lid subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0043248"(proteasome assembly)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR035295|interpro:IPR036390|interpro:IPR040773|interpro:IPR040780|mint:O00231|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5M32|rcsb pdb:5LN3|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VGZ|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHS|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/09/18 rogid:Hjx7D3Eq+fTpjE3D3fUujJN9gW89606 rogid:BgQKXK7gMMihacRCI+g/pBnRN309606 intact-crc:19BCF0F4A4AEA314|rigid:Z97f0uMdr+tC4vLZ/fcqtuDrCQg false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y4E8 uniprotkb:Q8TF66 intact:EBI-1043104|uniprotkb:Q9HCA6|uniprotkb:Q9UNP0|uniprotkb:Q9Y5B5|ensembl:ENSP00000280377|uniprotkb:Q9H8G9|uniprotkb:Q08AL5 intact:EBI-2511695|uniprotkb:Q7RTN7|uniprotkb:Q495Q6|ensembl:ENSP00000306276 psi-mi:ubp15_human(display_long)|uniprotkb:Unph4(gene name synonym)|uniprotkb:USP15(gene name)|psi-mi:USP15(display_short)|uniprotkb:KIAA0529(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 15(gene name synonym)|uniprotkb:Deubiquitinating enzyme 15(gene name synonym)|uniprotkb:Unph-2(gene name synonym)|uniprotkb:Ubiquitin thioesterase 15(gene name synonym) psi-mi:lrc15_human(display_long)|uniprotkb:LRRC15(gene name)|psi-mi:LRRC15(display_short)|uniprotkb:Leucine-rich repeat protein induced by beta-amyloid homolog(gene name synonym)|uniprotkb:LIB(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511673|imex:IM-12079-68 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000135655(gene)|ensembl:ENST00000280377(transcript)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0035520"(monoubiquitinated protein deubiquitination)|go:"GO:0035616"(histone H2B conserved C-terminal lysine deubiquitination)|go:"GO:0042802"(identical protein binding)|go:"GO:0046332"(SMAD binding)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0061649"(ubiquitin modification-dependent histone binding)|go:"GO:1900246"(positive regulation of RIG-I signaling pathway)|go:"GO:1905035"(negative regulation of antifungal innate immune response)|go:"GO:1990167"(protein K27-linked deubiquitination)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR013792(RNA 3'-terminal phosphate cyclase/enolpyruvate transferase, alpha/beta)|interpro:IPR018200|interpro:IPR028135|interpro:IPR028889|interpro:IPR029071|interpro:IPR029346|interpro:IPR035927|interpro:IPR038765|mint:Q9Y4E8|rcsb pdb:1W6V|rcsb pdb:3LMN|rcsb pdb:3PPA|rcsb pdb:3PV1|rcsb pdb:3T9L|rcsb pdb:4A3O|rcsb pdb:4A3P|rcsb pdb:5JJW|rcsb pdb:6CPM|rcsb pdb:6CRN|rcsb pdb:6DJ9|rcsb pdb:6GH9|rcsb pdb:6GHA|rcsb pdb:6ML1|reactome:R-HSA-2173788|reactome:R-HSA-5689603|reactome:R-HSA-5689880|refseq:NP_006304.1|refseq:NP_001239008.1|refseq:NP_001239007.1|dip:DIP-50239N refseq:NP_001128529.2|refseq:NP_570843.2|ensembl:ENSG00000172061(gene)|ensembl:ENST00000347624(transcript)|go:"GO:0001968"(fibronectin binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005615"(extracellular space)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031012"(extracellular matrix)|go:"GO:0043236"(laminin binding)|go:"GO:0046813"(receptor-mediated virion attachment to host cell)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903077"(negative regulation of protein localization to plasma membrane)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR032675|mint:Q8TF66 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/09/18 rogid:Hjx7D3Eq+fTpjE3D3fUujJN9gW89606 rogid:rU8egLkPqRi0D9QTtIQqKje1+y49606 intact-crc:19BCF0F4A4AEA314|rigid:Z97f0uMdr+tC4vLZ/fcqtuDrCQg false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y4E8 uniprotkb:Q9UKX2 intact:EBI-1043104|uniprotkb:Q9HCA6|uniprotkb:Q9UNP0|uniprotkb:Q9Y5B5|ensembl:ENSP00000280377|uniprotkb:Q9H8G9|uniprotkb:Q08AL5 intact:EBI-1049626|uniprotkb:A0AVL4|uniprotkb:Q14322|uniprotkb:Q16229|uniprotkb:Q86T56|ensembl:ENSP00000245503|ensembl:ENSP00000380367|uniprotkb:Q567P6 psi-mi:ubp15_human(display_long)|uniprotkb:Unph4(gene name synonym)|uniprotkb:USP15(gene name)|psi-mi:USP15(display_short)|uniprotkb:KIAA0529(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 15(gene name synonym)|uniprotkb:Deubiquitinating enzyme 15(gene name synonym)|uniprotkb:Unph-2(gene name synonym)|uniprotkb:Ubiquitin thioesterase 15(gene name synonym) psi-mi:myh2_human(display_long)|uniprotkb:MYH2(gene name)|psi-mi:MYH2(display_short)|uniprotkb:MYHSA2(gene name synonym)|uniprotkb:Myosin heavy chain 2(gene name synonym)|uniprotkb:Myosin heavy chain 2a(gene name synonym)|uniprotkb:Myosin heavy chain IIa(gene name synonym)|uniprotkb:Myosin heavy chain, skeletal muscle, adult 2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511673|imex:IM-12079-68 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000135655(gene)|ensembl:ENST00000280377(transcript)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0035520"(monoubiquitinated protein deubiquitination)|go:"GO:0035616"(histone H2B conserved C-terminal lysine deubiquitination)|go:"GO:0042802"(identical protein binding)|go:"GO:0046332"(SMAD binding)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0061649"(ubiquitin modification-dependent histone binding)|go:"GO:1900246"(positive regulation of RIG-I signaling pathway)|go:"GO:1905035"(negative regulation of antifungal innate immune response)|go:"GO:1990167"(protein K27-linked deubiquitination)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR013792(RNA 3'-terminal phosphate cyclase/enolpyruvate transferase, alpha/beta)|interpro:IPR018200|interpro:IPR028135|interpro:IPR028889|interpro:IPR029071|interpro:IPR029346|interpro:IPR035927|interpro:IPR038765|mint:Q9Y4E8|rcsb pdb:1W6V|rcsb pdb:3LMN|rcsb pdb:3PPA|rcsb pdb:3PV1|rcsb pdb:3T9L|rcsb pdb:4A3O|rcsb pdb:4A3P|rcsb pdb:5JJW|rcsb pdb:6CPM|rcsb pdb:6CRN|rcsb pdb:6DJ9|rcsb pdb:6GH9|rcsb pdb:6GHA|rcsb pdb:6ML1|reactome:R-HSA-2173788|reactome:R-HSA-5689603|reactome:R-HSA-5689880|refseq:NP_006304.1|refseq:NP_001239008.1|refseq:NP_001239007.1|dip:DIP-50239N refseq:NP_001093582.1|refseq:NP_060004.3|ensembl:ENST00000245503(transcript)|ensembl:ENST00000397183(transcript)|go:"GO:0000146"(microfilament motor activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005859"(muscle myosin complex)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006936"(muscle contraction)|go:"GO:0030016"(myofibril)|go:"GO:0030017"(sarcomere)|go:"GO:0030049"(muscle filament sliding)|go:"GO:0032982"(myosin filament)|go:"GO:0032991"(protein-containing complex)|go:"GO:0051015"(actin filament binding)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR001609(Myosin head, motor region)|interpro:IPR002928(Myosin tail)|interpro:IPR004009(Myosin, N-terminal, SH3-like)|interpro:IPR008989(Myosin S1 fragment, N-terminal)|interpro:IPR014751(DNA double-strand break repair and VJ recombination XRCC4, C-terminal)|interpro:IPR027417|interpro:IPR036961|mint:Q9UKX2|reactome:R-HSA-2029482|reactome:R-HSA-9664422|ensembl:ENSG00000125414(gene) psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/09/18 rogid:Hjx7D3Eq+fTpjE3D3fUujJN9gW89606 rogid:N23NJxmt8WtUT87k2VPsiB7juqQ9606 intact-crc:19BCF0F4A4AEA314|rigid:Z97f0uMdr+tC4vLZ/fcqtuDrCQg false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y4E8 uniprotkb:Q14525 intact:EBI-1043104|uniprotkb:Q9HCA6|uniprotkb:Q9UNP0|uniprotkb:Q9Y5B5|ensembl:ENSP00000280377|uniprotkb:Q9H8G9|uniprotkb:Q08AL5 intact:EBI-1049638|uniprotkb:O76010|ensembl:ENSP00000251646|ensembl:ENSP00000459509 psi-mi:ubp15_human(display_long)|uniprotkb:Unph4(gene name synonym)|uniprotkb:USP15(gene name)|psi-mi:USP15(display_short)|uniprotkb:KIAA0529(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 15(gene name synonym)|uniprotkb:Deubiquitinating enzyme 15(gene name synonym)|uniprotkb:Unph-2(gene name synonym)|uniprotkb:Ubiquitin thioesterase 15(gene name synonym) psi-mi:kt33b_human(display_long)|uniprotkb:KRTHA3B(gene name synonym)|uniprotkb:Hair keratin, type I Ha3-II(gene name synonym)|uniprotkb:Keratin-33B(gene name synonym)|uniprotkb:KRT33B(gene name)|psi-mi:KRT33B(display_short)|uniprotkb:HHA3-II(gene name synonym)|uniprotkb:HKA3B(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511673|imex:IM-12079-68 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000135655(gene)|ensembl:ENST00000280377(transcript)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0035520"(monoubiquitinated protein deubiquitination)|go:"GO:0035616"(histone H2B conserved C-terminal lysine deubiquitination)|go:"GO:0042802"(identical protein binding)|go:"GO:0046332"(SMAD binding)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0061649"(ubiquitin modification-dependent histone binding)|go:"GO:1900246"(positive regulation of RIG-I signaling pathway)|go:"GO:1905035"(negative regulation of antifungal innate immune response)|go:"GO:1990167"(protein K27-linked deubiquitination)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR013792(RNA 3'-terminal phosphate cyclase/enolpyruvate transferase, alpha/beta)|interpro:IPR018200|interpro:IPR028135|interpro:IPR028889|interpro:IPR029071|interpro:IPR029346|interpro:IPR035927|interpro:IPR038765|mint:Q9Y4E8|rcsb pdb:1W6V|rcsb pdb:3LMN|rcsb pdb:3PPA|rcsb pdb:3PV1|rcsb pdb:3T9L|rcsb pdb:4A3O|rcsb pdb:4A3P|rcsb pdb:5JJW|rcsb pdb:6CPM|rcsb pdb:6CRN|rcsb pdb:6DJ9|rcsb pdb:6GH9|rcsb pdb:6GHA|rcsb pdb:6ML1|reactome:R-HSA-2173788|reactome:R-HSA-5689603|reactome:R-HSA-5689880|refseq:NP_006304.1|refseq:NP_001239008.1|refseq:NP_001239007.1|dip:DIP-50239N refseq:NP_002270.1|ensembl:ENSG00000131738(gene)|ensembl:ENSG00000263012(gene)|ensembl:ENST00000251646(transcript)|ensembl:ENST00000570596(transcript)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005829"(cytosol)|go:"GO:0005882"(intermediate filament)|go:"GO:0007568"(aging)|go:"GO:0042633"(hair cycle)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002957(Keratin, type I)|interpro:IPR018039|interpro:IPR039008|mint:Q14525|reactome:R-HSA-6805567|reactome:R-HSA-6809371 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/09/18 rogid:Hjx7D3Eq+fTpjE3D3fUujJN9gW89606 rogid:TDqltAJBdpwMGaQsl0Lznc8Y7Ns9606 intact-crc:19BCF0F4A4AEA314|rigid:Z97f0uMdr+tC4vLZ/fcqtuDrCQg false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y4E8 uniprotkb:Q14533 intact:EBI-1043104|uniprotkb:Q9HCA6|uniprotkb:Q9UNP0|uniprotkb:Q9Y5B5|ensembl:ENSP00000280377|uniprotkb:Q9H8G9|uniprotkb:Q08AL5 intact:EBI-739648|uniprotkb:Q14846|uniprotkb:Q16274|uniprotkb:Q8WU52|uniprotkb:Q9BR74|uniprotkb:Q17R48|ensembl:ENSP00000369349 psi-mi:ubp15_human(display_long)|uniprotkb:Unph4(gene name synonym)|uniprotkb:USP15(gene name)|psi-mi:USP15(display_short)|uniprotkb:KIAA0529(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 15(gene name synonym)|uniprotkb:Deubiquitinating enzyme 15(gene name synonym)|uniprotkb:Unph-2(gene name synonym)|uniprotkb:Ubiquitin thioesterase 15(gene name synonym) psi-mi:krt81_human(display_long)|uniprotkb:Type II hair keratin Hb1(gene name synonym)|uniprotkb:ghHKb1(gene name synonym)|uniprotkb:Keratin-81(gene name synonym)|uniprotkb:Type-II keratin Kb21(gene name synonym)|uniprotkb:Hair keratin K2.9(gene name synonym)|uniprotkb:KRT81(gene name)|psi-mi:KRT81(display_short)|uniprotkb:KRTHB1(gene name synonym)|uniprotkb:MLN137(gene name synonym)|uniprotkb:Keratin, hair, basic, 1(gene name synonym)|uniprotkb:Metastatic lymph node 137 gene protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511673|imex:IM-12079-68 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000135655(gene)|ensembl:ENST00000280377(transcript)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0035520"(monoubiquitinated protein deubiquitination)|go:"GO:0035616"(histone H2B conserved C-terminal lysine deubiquitination)|go:"GO:0042802"(identical protein binding)|go:"GO:0046332"(SMAD binding)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0061649"(ubiquitin modification-dependent histone binding)|go:"GO:1900246"(positive regulation of RIG-I signaling pathway)|go:"GO:1905035"(negative regulation of antifungal innate immune response)|go:"GO:1990167"(protein K27-linked deubiquitination)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR013792(RNA 3'-terminal phosphate cyclase/enolpyruvate transferase, alpha/beta)|interpro:IPR018200|interpro:IPR028135|interpro:IPR028889|interpro:IPR029071|interpro:IPR029346|interpro:IPR035927|interpro:IPR038765|mint:Q9Y4E8|rcsb pdb:1W6V|rcsb pdb:3LMN|rcsb pdb:3PPA|rcsb pdb:3PV1|rcsb pdb:3T9L|rcsb pdb:4A3O|rcsb pdb:4A3P|rcsb pdb:5JJW|rcsb pdb:6CPM|rcsb pdb:6CRN|rcsb pdb:6DJ9|rcsb pdb:6GH9|rcsb pdb:6GHA|rcsb pdb:6ML1|reactome:R-HSA-2173788|reactome:R-HSA-5689603|reactome:R-HSA-5689880|refseq:NP_006304.1|refseq:NP_001239008.1|refseq:NP_001239007.1|dip:DIP-50239N refseq:NP_002272.2|ensembl:ENST00000327741(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005829"(cytosol)|go:"GO:0045095"(keratin filament)|interpro:IPR003054(Type II keratin)|ensembl:ENSG00000205426(gene)|interpro:IPR018039|interpro:IPR032444|interpro:IPR039008|reactome:R-HSA-6805567|reactome:R-HSA-6809371 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/09/18 rogid:Hjx7D3Eq+fTpjE3D3fUujJN9gW89606 rogid:Y/1YhLCN54gK8DZQyc4OqfNDwAs9606 intact-crc:19BCF0F4A4AEA314|rigid:Z97f0uMdr+tC4vLZ/fcqtuDrCQg false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y4E8 uniprotkb:Q9Y333 intact:EBI-1043104|uniprotkb:Q9HCA6|uniprotkb:Q9UNP0|uniprotkb:Q9Y5B5|ensembl:ENSP00000280377|uniprotkb:Q9H8G9|uniprotkb:Q08AL5 intact:EBI-347416|uniprotkb:Q6FGG1|ensembl:ENSP00000414006|ensembl:ENSP00000414634|ensembl:ENSP00000406280|ensembl:ENSP00000364813|ensembl:ENSP00000372883|ensembl:ENSP00000403345 psi-mi:ubp15_human(display_long)|uniprotkb:Unph4(gene name synonym)|uniprotkb:USP15(gene name)|psi-mi:USP15(display_short)|uniprotkb:KIAA0529(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 15(gene name synonym)|uniprotkb:Deubiquitinating enzyme 15(gene name synonym)|uniprotkb:Unph-2(gene name synonym)|uniprotkb:Ubiquitin thioesterase 15(gene name synonym) psi-mi:lsm2_human(display_long)|uniprotkb:LSM2(gene name)|psi-mi:LSM2(display_short)|uniprotkb:C6orf28(gene name synonym)|uniprotkb:G7B(gene name synonym)|uniprotkb:snRNP core Sm-like protein Sm-x5(gene name synonym)|uniprotkb:Small nuclear ribonuclear protein D homolog(gene name synonym)|uniprotkb:Protein G7b(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511673|imex:IM-12079-68 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000135655(gene)|ensembl:ENST00000280377(transcript)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0035520"(monoubiquitinated protein deubiquitination)|go:"GO:0035616"(histone H2B conserved C-terminal lysine deubiquitination)|go:"GO:0042802"(identical protein binding)|go:"GO:0046332"(SMAD binding)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0061649"(ubiquitin modification-dependent histone binding)|go:"GO:1900246"(positive regulation of RIG-I signaling pathway)|go:"GO:1905035"(negative regulation of antifungal innate immune response)|go:"GO:1990167"(protein K27-linked deubiquitination)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR013792(RNA 3'-terminal phosphate cyclase/enolpyruvate transferase, alpha/beta)|interpro:IPR018200|interpro:IPR028135|interpro:IPR028889|interpro:IPR029071|interpro:IPR029346|interpro:IPR035927|interpro:IPR038765|mint:Q9Y4E8|rcsb pdb:1W6V|rcsb pdb:3LMN|rcsb pdb:3PPA|rcsb pdb:3PV1|rcsb pdb:3T9L|rcsb pdb:4A3O|rcsb pdb:4A3P|rcsb pdb:5JJW|rcsb pdb:6CPM|rcsb pdb:6CRN|rcsb pdb:6DJ9|rcsb pdb:6GH9|rcsb pdb:6GHA|rcsb pdb:6ML1|reactome:R-HSA-2173788|reactome:R-HSA-5689603|reactome:R-HSA-5689880|refseq:NP_006304.1|refseq:NP_001239008.1|refseq:NP_001239007.1|dip:DIP-50239N refseq:NP_067000.1|ensembl:ENST00000375661(transcript)|ensembl:ENST00000383391(transcript)|ensembl:ENST00000424975(transcript)|ensembl:ENST00000432122(transcript)|ensembl:ENST00000434125(transcript)|ensembl:ENST00000455705(transcript)|go:"GO:0000244"(spliceosomal tri-snRNP complex assembly)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000932"(P-body)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005688"(U6 snRNP)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006402"(mRNA catabolic process)|go:"GO:0017070"(U6 snRNA binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071011"(precatalytic spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0120115"(Lsm2-8 complex)|go:"GO:1990726"(Lsm1-7-Pat1 complex)|interpro:IPR001163(Like-Sm ribonucleoprotein, core)|interpro:IPR010920(Like-Sm ribonucleoprotein-related, core)|interpro:IPR016654(U6 snRNA-associated Sm-like protein LSm2)|mint:Q9Y333|rcsb pdb:3JCR|rcsb pdb:5O9Z|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6QW6|rcsb pdb:6QX9|rcsb pdb:7ABG|reactome:R-HSA-430039|reactome:R-HSA-72163|reactome:R-HSA-72165|ensembl:ENSG00000172850(gene)|ensembl:ENSG00000204392(gene)|ensembl:ENSG00000224979(gene)|ensembl:ENSG00000225998(gene)|ensembl:ENSG00000231502(gene)|ensembl:ENSG00000236826(gene)|dip:DIP-31139N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/09/18 rogid:Hjx7D3Eq+fTpjE3D3fUujJN9gW89606 rogid:lReyYTJxC/WlYg/ekKaqZiNNdVM9606 intact-crc:19BCF0F4A4AEA314|rigid:Z97f0uMdr+tC4vLZ/fcqtuDrCQg false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y4E8 uniprotkb:O43172 intact:EBI-1043104|uniprotkb:Q9HCA6|uniprotkb:Q9UNP0|uniprotkb:Q9Y5B5|ensembl:ENSP00000280377|uniprotkb:Q9H8G9|uniprotkb:Q08AL5 intact:EBI-718395|uniprotkb:O43445|uniprotkb:O43864|uniprotkb:Q96DG2|uniprotkb:Q96IK4|uniprotkb:Q5T1M8|ensembl:ENSP00000363315 psi-mi:ubp15_human(display_long)|uniprotkb:Unph4(gene name synonym)|uniprotkb:USP15(gene name)|psi-mi:USP15(display_short)|uniprotkb:KIAA0529(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 15(gene name synonym)|uniprotkb:Deubiquitinating enzyme 15(gene name synonym)|uniprotkb:Unph-2(gene name synonym)|uniprotkb:Ubiquitin thioesterase 15(gene name synonym) psi-mi:prp4_human(display_long)|uniprotkb:U4/U6 snRNP 60 kDa protein(gene name synonym)|uniprotkb:WD splicing factor Prp4(gene name synonym)|uniprotkb:PRP4 homolog(gene name synonym)|uniprotkb:PRPF4(gene name)|psi-mi:PRPF4(display_short)|uniprotkb:PRP4(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511673|imex:IM-12079-68 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000135655(gene)|ensembl:ENST00000280377(transcript)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0035520"(monoubiquitinated protein deubiquitination)|go:"GO:0035616"(histone H2B conserved C-terminal lysine deubiquitination)|go:"GO:0042802"(identical protein binding)|go:"GO:0046332"(SMAD binding)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0061649"(ubiquitin modification-dependent histone binding)|go:"GO:1900246"(positive regulation of RIG-I signaling pathway)|go:"GO:1905035"(negative regulation of antifungal innate immune response)|go:"GO:1990167"(protein K27-linked deubiquitination)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR013792(RNA 3'-terminal phosphate cyclase/enolpyruvate transferase, alpha/beta)|interpro:IPR018200|interpro:IPR028135|interpro:IPR028889|interpro:IPR029071|interpro:IPR029346|interpro:IPR035927|interpro:IPR038765|mint:Q9Y4E8|rcsb pdb:1W6V|rcsb pdb:3LMN|rcsb pdb:3PPA|rcsb pdb:3PV1|rcsb pdb:3T9L|rcsb pdb:4A3O|rcsb pdb:4A3P|rcsb pdb:5JJW|rcsb pdb:6CPM|rcsb pdb:6CRN|rcsb pdb:6DJ9|rcsb pdb:6GH9|rcsb pdb:6GHA|rcsb pdb:6ML1|reactome:R-HSA-2173788|reactome:R-HSA-5689603|reactome:R-HSA-5689880|refseq:NP_006304.1|refseq:NP_001239008.1|refseq:NP_001239007.1|dip:DIP-50239N refseq:NP_004688.2|refseq:NP_001231855.1|ensembl:ENSG00000136875(gene)|ensembl:ENST00000374199(transcript)|go:"GO:0000375"(RNA splicing, via transesterification reactions)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0071001"(U4/U6 snRNP)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0097525"(spliceosomal snRNP complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR014906("Pre-mRNA processing factor 4 (PRP4) like")|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|interpro:IPR015943(WD40/YVTN repeat-like)|go:"GO:0006396"(RNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0015030"(Cajal body)|go:"GO:0016607"(nuclear speck)|go:"GO:0017070"(U6 snRNA binding)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036285|interpro:IPR036322|mint:O43172|rcsb pdb:1MZW|rcsb pdb:3JCR|rcsb pdb:5O9Z|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6QW6|rcsb pdb:6QX9|reactome:R-HSA-72163|go:"GO:0030621"(U4 snRNA binding) psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/09/18 rogid:Hjx7D3Eq+fTpjE3D3fUujJN9gW89606 rogid:PPTNuhEFj4D+gTv/ctTTMzGmFA09606 intact-crc:19BCF0F4A4AEA314|rigid:Z97f0uMdr+tC4vLZ/fcqtuDrCQg false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y4E8 uniprotkb:P62312 intact:EBI-1043104|uniprotkb:Q9HCA6|uniprotkb:Q9UNP0|uniprotkb:Q9Y5B5|ensembl:ENSP00000280377|uniprotkb:Q9H8G9|uniprotkb:Q08AL5 intact:EBI-373310|uniprotkb:Q9Y4Y8|uniprotkb:Q4W5J5|ensembl:ENSP00000296581|ensembl:ENSP00000420929|ensembl:ENSP00000422392|ensembl:ENSP00000427036|ensembl:ENSP00000497311 psi-mi:ubp15_human(display_long)|uniprotkb:Unph4(gene name synonym)|uniprotkb:USP15(gene name)|psi-mi:USP15(display_short)|uniprotkb:KIAA0529(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 15(gene name synonym)|uniprotkb:Deubiquitinating enzyme 15(gene name synonym)|uniprotkb:Unph-2(gene name synonym)|uniprotkb:Ubiquitin thioesterase 15(gene name synonym) psi-mi:lsm6_human(display_long)|uniprotkb:LSM6(gene name)|psi-mi:LSM6(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511673|imex:IM-12079-68 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000135655(gene)|ensembl:ENST00000280377(transcript)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0035520"(monoubiquitinated protein deubiquitination)|go:"GO:0035616"(histone H2B conserved C-terminal lysine deubiquitination)|go:"GO:0042802"(identical protein binding)|go:"GO:0046332"(SMAD binding)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0061649"(ubiquitin modification-dependent histone binding)|go:"GO:1900246"(positive regulation of RIG-I signaling pathway)|go:"GO:1905035"(negative regulation of antifungal innate immune response)|go:"GO:1990167"(protein K27-linked deubiquitination)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR013792(RNA 3'-terminal phosphate cyclase/enolpyruvate transferase, alpha/beta)|interpro:IPR018200|interpro:IPR028135|interpro:IPR028889|interpro:IPR029071|interpro:IPR029346|interpro:IPR035927|interpro:IPR038765|mint:Q9Y4E8|rcsb pdb:1W6V|rcsb pdb:3LMN|rcsb pdb:3PPA|rcsb pdb:3PV1|rcsb pdb:3T9L|rcsb pdb:4A3O|rcsb pdb:4A3P|rcsb pdb:5JJW|rcsb pdb:6CPM|rcsb pdb:6CRN|rcsb pdb:6DJ9|rcsb pdb:6GH9|rcsb pdb:6GHA|rcsb pdb:6ML1|reactome:R-HSA-2173788|reactome:R-HSA-5689603|reactome:R-HSA-5689880|refseq:NP_006304.1|refseq:NP_001239008.1|refseq:NP_001239007.1|dip:DIP-50239N refseq:NP_009011.1|ensembl:ENSG00000164167(gene)|ensembl:ENST00000296581(transcript)|ensembl:ENST00000502781(transcript)|ensembl:ENST00000504181(transcript)|ensembl:ENST00000515311(transcript)|ensembl:ENST00000649747(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000932"(P-body)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005688"(U6 snRNP)|go:"GO:0005730"(nucleolus)|go:"GO:0005732"("sno(s)RNA-containing ribonucleoprotein complex")|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006402"(mRNA catabolic process)|go:"GO:0008033"(tRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0030490"(maturation of SSU-rRNA)|go:"GO:0030532"(small nuclear ribonucleoprotein complex)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0120115"(Lsm2-8 complex)|interpro:IPR001163(Like-Sm ribonucleoprotein, core)|interpro:IPR010920(Like-Sm ribonucleoprotein-related, core)|interpro:IPR016487(Small nuclear ribonucleoprotein SmF)|mint:P62312|rcsb pdb:3JCR|rcsb pdb:5O9Z|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6QW6|rcsb pdb:6QX9|rcsb pdb:7ABG|reactome:R-HSA-430039|reactome:R-HSA-72163|refseq:XP_016863161.1|refseq:XP_016863162.1|dip:DIP-31128N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/09/18 rogid:Hjx7D3Eq+fTpjE3D3fUujJN9gW89606 rogid:knWeW+soIyeLSg0Xbe79er748hE9606 intact-crc:19BCF0F4A4AEA314|rigid:Z97f0uMdr+tC4vLZ/fcqtuDrCQg false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y4E8 uniprotkb:C4AM86 intact:EBI-1043104|uniprotkb:Q9HCA6|uniprotkb:Q9UNP0|uniprotkb:Q9Y5B5|ensembl:ENSP00000280377|uniprotkb:Q9H8G9|uniprotkb:Q08AL5 intact:EBI-2511700|ensembl:ENSP00000246639 psi-mi:ubp15_human(display_long)|uniprotkb:Unph4(gene name synonym)|uniprotkb:USP15(gene name)|psi-mi:USP15(display_short)|uniprotkb:KIAA0529(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 15(gene name synonym)|uniprotkb:Deubiquitinating enzyme 15(gene name synonym)|uniprotkb:Unph-2(gene name synonym)|uniprotkb:Ubiquitin thioesterase 15(gene name synonym) psi-mi:c4am86_human(display_long)|uniprotkb:KRT35(gene name)|psi-mi:KRT35(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511673|imex:IM-12079-68 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000135655(gene)|ensembl:ENST00000280377(transcript)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0035520"(monoubiquitinated protein deubiquitination)|go:"GO:0035616"(histone H2B conserved C-terminal lysine deubiquitination)|go:"GO:0042802"(identical protein binding)|go:"GO:0046332"(SMAD binding)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0061649"(ubiquitin modification-dependent histone binding)|go:"GO:1900246"(positive regulation of RIG-I signaling pathway)|go:"GO:1905035"(negative regulation of antifungal innate immune response)|go:"GO:1990167"(protein K27-linked deubiquitination)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR013792(RNA 3'-terminal phosphate cyclase/enolpyruvate transferase, alpha/beta)|interpro:IPR018200|interpro:IPR028135|interpro:IPR028889|interpro:IPR029071|interpro:IPR029346|interpro:IPR035927|interpro:IPR038765|mint:Q9Y4E8|rcsb pdb:1W6V|rcsb pdb:3LMN|rcsb pdb:3PPA|rcsb pdb:3PV1|rcsb pdb:3T9L|rcsb pdb:4A3O|rcsb pdb:4A3P|rcsb pdb:5JJW|rcsb pdb:6CPM|rcsb pdb:6CRN|rcsb pdb:6DJ9|rcsb pdb:6GH9|rcsb pdb:6GHA|rcsb pdb:6ML1|reactome:R-HSA-2173788|reactome:R-HSA-5689603|reactome:R-HSA-5689880|refseq:NP_006304.1|refseq:NP_001239008.1|refseq:NP_001239007.1|dip:DIP-50239N go:"GO:0005882"(intermediate filament)|interpro:IPR002957(Keratin, type I)|interpro:IPR018039|interpro:IPR039008|ensembl:ENSG00000197079(gene)|ensembl:ENST00000246639(transcript)|go:"GO:0005198"(structural molecule activity) psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/09/18 rogid:Hjx7D3Eq+fTpjE3D3fUujJN9gW89606 rogid:w6hms5RnF3IJn4fZcLxczK68/bc9606 intact-crc:19BCF0F4A4AEA314|rigid:Z97f0uMdr+tC4vLZ/fcqtuDrCQg false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y4E8 uniprotkb:P04075 intact:EBI-1043104|uniprotkb:Q9HCA6|uniprotkb:Q9UNP0|uniprotkb:Q9Y5B5|ensembl:ENSP00000280377|uniprotkb:Q9H8G9|uniprotkb:Q08AL5 intact:EBI-709613|uniprotkb:Q6FH76|uniprotkb:Q96B15|uniprotkb:Q9BWD9|uniprotkb:B4DXI7|uniprotkb:Q6FI10|uniprotkb:Q9UCN2|ensembl:ENSP00000400452|ensembl:ENSP00000455700|ensembl:ENSP00000455800|ensembl:ENSP00000494188 psi-mi:ubp15_human(display_long)|uniprotkb:Unph4(gene name synonym)|uniprotkb:USP15(gene name)|psi-mi:USP15(display_short)|uniprotkb:KIAA0529(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 15(gene name synonym)|uniprotkb:Deubiquitinating enzyme 15(gene name synonym)|uniprotkb:Unph-2(gene name synonym)|uniprotkb:Ubiquitin thioesterase 15(gene name synonym) psi-mi:aldoa_human(display_long)|uniprotkb:Muscle-type aldolase(gene name synonym)|uniprotkb:Lung cancer antigen NY-LU-1(gene name synonym)|uniprotkb:ALDOA(gene name)|psi-mi:ALDOA(display_short)|uniprotkb:ALDA(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511673|imex:IM-12079-68 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000135655(gene)|ensembl:ENST00000280377(transcript)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0035520"(monoubiquitinated protein deubiquitination)|go:"GO:0035616"(histone H2B conserved C-terminal lysine deubiquitination)|go:"GO:0042802"(identical protein binding)|go:"GO:0046332"(SMAD binding)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0061649"(ubiquitin modification-dependent histone binding)|go:"GO:1900246"(positive regulation of RIG-I signaling pathway)|go:"GO:1905035"(negative regulation of antifungal innate immune response)|go:"GO:1990167"(protein K27-linked deubiquitination)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR013792(RNA 3'-terminal phosphate cyclase/enolpyruvate transferase, alpha/beta)|interpro:IPR018200|interpro:IPR028135|interpro:IPR028889|interpro:IPR029071|interpro:IPR029346|interpro:IPR035927|interpro:IPR038765|mint:Q9Y4E8|rcsb pdb:1W6V|rcsb pdb:3LMN|rcsb pdb:3PPA|rcsb pdb:3PV1|rcsb pdb:3T9L|rcsb pdb:4A3O|rcsb pdb:4A3P|rcsb pdb:5JJW|rcsb pdb:6CPM|rcsb pdb:6CRN|rcsb pdb:6DJ9|rcsb pdb:6GH9|rcsb pdb:6GHA|rcsb pdb:6ML1|reactome:R-HSA-2173788|reactome:R-HSA-5689603|reactome:R-HSA-5689880|refseq:NP_006304.1|refseq:NP_001239008.1|refseq:NP_001239007.1|dip:DIP-50239N refseq:NP_000025.1|refseq:NP_001121089.1|refseq:NP_001230106.1|refseq:NP_908930.1|refseq:NP_908932.1|refseq:XP_011544070.1|ensembl:ENSG00000149925(gene)|ensembl:ENST00000412304(transcript)|ensembl:ENST00000563060(transcript)|ensembl:ENST00000569545(transcript)|ensembl:ENST00000643777(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0004332"(fructose-bisphosphate aldolase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006000"(fructose metabolic process)|go:"GO:0006096"(glycolytic process)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0006941"(striated muscle contraction)|go:"GO:0007015"(actin filament organization)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0015631"(tubulin binding)|go:"GO:0016020"(membrane)|go:"GO:0030388"(fructose 1,6-bisphosphate metabolic process)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031430"(M band)|go:"GO:0031674"(I band)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042802"(identical protein binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0061827"(sperm head)|go:"GO:0070061"(fructose binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904724"(tertiary granule lumen)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000741(Fructose-bisphosphate aldolase, class-I)|interpro:IPR013785(Aldolase-type TIM barrel)|interpro:IPR029768|mint:P04075|rcsb pdb:1ALD|rcsb pdb:2ALD|rcsb pdb:4ALD|rcsb pdb:5KY6|reactome:R-HSA-114608|reactome:R-HSA-6798695|reactome:R-HSA-70171|reactome:R-HSA-70263 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/09/18 rogid:Hjx7D3Eq+fTpjE3D3fUujJN9gW89606 rogid:/UgTtKPQj2ZyKznKIfE9OVUcDFI9606 intact-crc:19BCF0F4A4AEA314|rigid:Z97f0uMdr+tC4vLZ/fcqtuDrCQg false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y4E8 uniprotkb:Q7L2J0 intact:EBI-1043104|uniprotkb:Q9HCA6|uniprotkb:Q9UNP0|uniprotkb:Q9Y5B5|ensembl:ENSP00000280377|uniprotkb:Q9H8G9|uniprotkb:Q08AL5 intact:EBI-2371983|uniprotkb:Q9NPD4|uniprotkb:B3KP86|uniprotkb:D6W5V7|ensembl:ENSP00000308546 psi-mi:ubp15_human(display_long)|uniprotkb:Unph4(gene name synonym)|uniprotkb:USP15(gene name)|psi-mi:USP15(display_short)|uniprotkb:KIAA0529(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 15(gene name synonym)|uniprotkb:Deubiquitinating enzyme 15(gene name synonym)|uniprotkb:Unph-2(gene name synonym)|uniprotkb:Ubiquitin thioesterase 15(gene name synonym) psi-mi:mepce_human(display_long)|uniprotkb:MEPCE(gene name)|psi-mi:MEPCE(display_short)|uniprotkb:BCDIN3(gene name synonym)|uniprotkb:Bicoid-interacting protein 3 homolog(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511673|imex:IM-12079-68 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000135655(gene)|ensembl:ENST00000280377(transcript)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0035520"(monoubiquitinated protein deubiquitination)|go:"GO:0035616"(histone H2B conserved C-terminal lysine deubiquitination)|go:"GO:0042802"(identical protein binding)|go:"GO:0046332"(SMAD binding)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0061649"(ubiquitin modification-dependent histone binding)|go:"GO:1900246"(positive regulation of RIG-I signaling pathway)|go:"GO:1905035"(negative regulation of antifungal innate immune response)|go:"GO:1990167"(protein K27-linked deubiquitination)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR013792(RNA 3'-terminal phosphate cyclase/enolpyruvate transferase, alpha/beta)|interpro:IPR018200|interpro:IPR028135|interpro:IPR028889|interpro:IPR029071|interpro:IPR029346|interpro:IPR035927|interpro:IPR038765|mint:Q9Y4E8|rcsb pdb:1W6V|rcsb pdb:3LMN|rcsb pdb:3PPA|rcsb pdb:3PV1|rcsb pdb:3T9L|rcsb pdb:4A3O|rcsb pdb:4A3P|rcsb pdb:5JJW|rcsb pdb:6CPM|rcsb pdb:6CRN|rcsb pdb:6DJ9|rcsb pdb:6GH9|rcsb pdb:6GHA|rcsb pdb:6ML1|reactome:R-HSA-2173788|reactome:R-HSA-5689603|reactome:R-HSA-5689880|refseq:NP_006304.1|refseq:NP_001239008.1|refseq:NP_001239007.1|dip:DIP-50239N refseq:XP_011514712.1|refseq:NP_001181919.1|refseq:NP_001181920.1|refseq:NP_001181921.1|refseq:NP_062552.2|ensembl:ENSG00000146834(gene)|ensembl:ENST00000310512(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001510"(RNA methylation)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0008171"(O-methyltransferase activity)|go:"GO:0008173"(RNA methyltransferase activity)|go:"GO:0008757"(S-adenosylmethionine-dependent methyltransferase activity)|go:"GO:0016073"(snRNA metabolic process)|go:"GO:0017069"(snRNA binding)|go:"GO:0035562"(negative regulation of chromatin binding)|go:"GO:0040031"(snRNA modification)|go:"GO:0097322"(7SK snRNA binding)|go:"GO:0120259"(7SK snRNP)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1904871"(positive regulation of protein localization to Cajal body)|go:"GO:1905382"(positive regulation of snRNA transcription by RNA polymerase II)|go:"GO:1990276"(RNA 5'-methyltransferase activity)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR010675(Bicoid-interacting 3)|interpro:IPR024160|interpro:IPR025714|interpro:IPR029063|interpro:IPR039772|mint:Q7L2J0|rcsb pdb:5UNA|rcsb pdb:6DCB|rcsb pdb:6DCC psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/09/18 rogid:Hjx7D3Eq+fTpjE3D3fUujJN9gW89606 rogid:VGhJoO3FD7nsJPVSBsKuKsPJzEM9606 intact-crc:19BCF0F4A4AEA314|rigid:Z97f0uMdr+tC4vLZ/fcqtuDrCQg false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y4E8 uniprotkb:P27482 intact:EBI-1043104|uniprotkb:Q9HCA6|uniprotkb:Q9UNP0|uniprotkb:Q9Y5B5|ensembl:ENSP00000280377|uniprotkb:Q9H8G9|uniprotkb:Q08AL5 intact:EBI-747537|uniprotkb:Q5SQI4|uniprotkb:B2R9V6|ensembl:ENSP00000315299 psi-mi:ubp15_human(display_long)|uniprotkb:Unph4(gene name synonym)|uniprotkb:USP15(gene name)|psi-mi:USP15(display_short)|uniprotkb:KIAA0529(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 15(gene name synonym)|uniprotkb:Deubiquitinating enzyme 15(gene name synonym)|uniprotkb:Unph-2(gene name synonym)|uniprotkb:Ubiquitin thioesterase 15(gene name synonym) psi-mi:call3_human(display_long)|uniprotkb:Calmodulin-related protein NB-1(gene name synonym)|uniprotkb:CaM-like protein(gene name synonym)|uniprotkb:CALML3(gene name)|psi-mi:CALML3(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511673|imex:IM-12079-68 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000135655(gene)|ensembl:ENST00000280377(transcript)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0035520"(monoubiquitinated protein deubiquitination)|go:"GO:0035616"(histone H2B conserved C-terminal lysine deubiquitination)|go:"GO:0042802"(identical protein binding)|go:"GO:0046332"(SMAD binding)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0061649"(ubiquitin modification-dependent histone binding)|go:"GO:1900246"(positive regulation of RIG-I signaling pathway)|go:"GO:1905035"(negative regulation of antifungal innate immune response)|go:"GO:1990167"(protein K27-linked deubiquitination)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR013792(RNA 3'-terminal phosphate cyclase/enolpyruvate transferase, alpha/beta)|interpro:IPR018200|interpro:IPR028135|interpro:IPR028889|interpro:IPR029071|interpro:IPR029346|interpro:IPR035927|interpro:IPR038765|mint:Q9Y4E8|rcsb pdb:1W6V|rcsb pdb:3LMN|rcsb pdb:3PPA|rcsb pdb:3PV1|rcsb pdb:3T9L|rcsb pdb:4A3O|rcsb pdb:4A3P|rcsb pdb:5JJW|rcsb pdb:6CPM|rcsb pdb:6CRN|rcsb pdb:6DJ9|rcsb pdb:6GH9|rcsb pdb:6GHA|rcsb pdb:6ML1|reactome:R-HSA-2173788|reactome:R-HSA-5689603|reactome:R-HSA-5689880|refseq:NP_006304.1|refseq:NP_001239008.1|refseq:NP_001239007.1|dip:DIP-50239N refseq:NP_005176.1|ensembl:ENSG00000178363(gene)|ensembl:ENST00000315238(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|mint:P27482|rcsb pdb:1GGZ psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/09/18 rogid:Hjx7D3Eq+fTpjE3D3fUujJN9gW89606 rogid:7yRRBYvsbUxzIvnYaNmaIJ42i5Y9606 intact-crc:19BCF0F4A4AEA314|rigid:Z97f0uMdr+tC4vLZ/fcqtuDrCQg false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y4E8 uniprotkb:P15090 intact:EBI-1043104|uniprotkb:Q9HCA6|uniprotkb:Q9UNP0|uniprotkb:Q9Y5B5|ensembl:ENSP00000280377|uniprotkb:Q9H8G9|uniprotkb:Q08AL5 intact:EBI-715333|uniprotkb:Q6IBA1|ensembl:ENSP00000256104 psi-mi:ubp15_human(display_long)|uniprotkb:Unph4(gene name synonym)|uniprotkb:USP15(gene name)|psi-mi:USP15(display_short)|uniprotkb:KIAA0529(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 15(gene name synonym)|uniprotkb:Deubiquitinating enzyme 15(gene name synonym)|uniprotkb:Unph-2(gene name synonym)|uniprotkb:Ubiquitin thioesterase 15(gene name synonym) psi-mi:fabp4_human(display_long)|uniprotkb:Adipocyte-type fatty acid-binding protein(gene name synonym)|uniprotkb:Fatty acid-binding protein 4(gene name synonym)|uniprotkb:Adipocyte lipid-binding protein(gene name synonym)|uniprotkb:FABP4(gene name)|psi-mi:FABP4(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511673|imex:IM-12079-68 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000135655(gene)|ensembl:ENST00000280377(transcript)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0035520"(monoubiquitinated protein deubiquitination)|go:"GO:0035616"(histone H2B conserved C-terminal lysine deubiquitination)|go:"GO:0042802"(identical protein binding)|go:"GO:0046332"(SMAD binding)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0061649"(ubiquitin modification-dependent histone binding)|go:"GO:1900246"(positive regulation of RIG-I signaling pathway)|go:"GO:1905035"(negative regulation of antifungal innate immune response)|go:"GO:1990167"(protein K27-linked deubiquitination)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR013792(RNA 3'-terminal phosphate cyclase/enolpyruvate transferase, alpha/beta)|interpro:IPR018200|interpro:IPR028135|interpro:IPR028889|interpro:IPR029071|interpro:IPR029346|interpro:IPR035927|interpro:IPR038765|mint:Q9Y4E8|rcsb pdb:1W6V|rcsb pdb:3LMN|rcsb pdb:3PPA|rcsb pdb:3PV1|rcsb pdb:3T9L|rcsb pdb:4A3O|rcsb pdb:4A3P|rcsb pdb:5JJW|rcsb pdb:6CPM|rcsb pdb:6CRN|rcsb pdb:6DJ9|rcsb pdb:6GH9|rcsb pdb:6GHA|rcsb pdb:6ML1|reactome:R-HSA-2173788|reactome:R-HSA-5689603|reactome:R-HSA-5689880|refseq:NP_006304.1|refseq:NP_001239008.1|refseq:NP_001239007.1|dip:DIP-50239N refseq:NP_001433.1|go:"GO:0036041"(long-chain fatty acid binding)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050872"(white fat cell differentiation)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0051427"(hormone receptor binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071285"(cellular response to lithium ion)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|interpro:IPR000463(Cytosolic fatty-acid binding)|interpro:IPR000566(Lipocalin-related protein and Bos/Can/Equ allergen)|interpro:IPR012674(Calycin)|interpro:IPR031259|interpro:IPR033073|rcsb pdb:1TOU|rcsb pdb:1TOW|rcsb pdb:2HNX|rcsb pdb:2NNQ|go:"GO:0015909"(long-chain fatty acid transport)|ensembl:ENSG00000170323(gene)|ensembl:ENST00000256104(transcript)|go:"GO:0005324"(long-chain fatty acid transporter activity)|go:"GO:0005504"(fatty acid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0009617"(response to bacterium)|rcsb pdb:3FR4|rcsb pdb:3FR5|rcsb pdb:3P6C|rcsb pdb:3P6D|rcsb pdb:3P6E|rcsb pdb:3P6F|rcsb pdb:3P6G|rcsb pdb:3P6H|rcsb pdb:3Q6L|rcsb pdb:3RZY|rcsb pdb:4NNS|rcsb pdb:4NNT|rcsb pdb:5D45|rcsb pdb:5D47|rcsb pdb:5D48|rcsb pdb:5D4A|rcsb pdb:5EDB|rcsb pdb:5EDC|rcsb pdb:5HZ6|rcsb pdb:5HZ8|rcsb pdb:5Y0F|rcsb pdb:5Y0G|rcsb pdb:3FR2|rcsb pdb:5Y0X|rcsb pdb:5Y12|rcsb pdb:5Y13|rcsb pdb:6AYL|rcsb pdb:6LJS|rcsb pdb:6LJT|rcsb pdb:6LJU|rcsb pdb:6LJV|rcsb pdb:6LJW|rcsb pdb:6LJX|reactome:R-HSA-163560|reactome:R-HSA-381340 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/09/18 rogid:Hjx7D3Eq+fTpjE3D3fUujJN9gW89606 rogid:YxVg+XQmR5Ywtww0wPSq3CJQIDw9606 intact-crc:19BCF0F4A4AEA314|rigid:Z97f0uMdr+tC4vLZ/fcqtuDrCQg false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y4E8 uniprotkb:O75150 intact:EBI-1043104|uniprotkb:Q9HCA6|uniprotkb:Q9UNP0|uniprotkb:Q9Y5B5|ensembl:ENSP00000280377|uniprotkb:Q9H8G9|uniprotkb:Q08AL5 intact:EBI-744408|uniprotkb:Q6AHZ6|uniprotkb:Q6N005|uniprotkb:Q7L3T6|uniprotkb:Q8N615|uniprotkb:Q96T18|uniprotkb:Q9BSV9|uniprotkb:Q9HC82|ensembl:ENSP00000325677|uniprotkb:A0A024QZG0 psi-mi:ubp15_human(display_long)|uniprotkb:Unph4(gene name synonym)|uniprotkb:USP15(gene name)|psi-mi:USP15(display_short)|uniprotkb:KIAA0529(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 15(gene name synonym)|uniprotkb:Deubiquitinating enzyme 15(gene name synonym)|uniprotkb:Unph-2(gene name synonym)|uniprotkb:Ubiquitin thioesterase 15(gene name synonym) psi-mi:bre1b_human(display_long)|uniprotkb:95 kDa retinoblastoma-associated protein(gene name synonym)|uniprotkb:RING finger protein 40(gene name synonym)|uniprotkb:RNF40(gene name)|psi-mi:RNF40(display_short)|uniprotkb:BRE1B(gene name synonym)|uniprotkb:KIAA0661(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BRE1B(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511673|imex:IM-12079-68 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000135655(gene)|ensembl:ENST00000280377(transcript)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0035520"(monoubiquitinated protein deubiquitination)|go:"GO:0035616"(histone H2B conserved C-terminal lysine deubiquitination)|go:"GO:0042802"(identical protein binding)|go:"GO:0046332"(SMAD binding)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0061649"(ubiquitin modification-dependent histone binding)|go:"GO:1900246"(positive regulation of RIG-I signaling pathway)|go:"GO:1905035"(negative regulation of antifungal innate immune response)|go:"GO:1990167"(protein K27-linked deubiquitination)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR013792(RNA 3'-terminal phosphate cyclase/enolpyruvate transferase, alpha/beta)|interpro:IPR018200|interpro:IPR028135|interpro:IPR028889|interpro:IPR029071|interpro:IPR029346|interpro:IPR035927|interpro:IPR038765|mint:Q9Y4E8|rcsb pdb:1W6V|rcsb pdb:3LMN|rcsb pdb:3PPA|rcsb pdb:3PV1|rcsb pdb:3T9L|rcsb pdb:4A3O|rcsb pdb:4A3P|rcsb pdb:5JJW|rcsb pdb:6CPM|rcsb pdb:6CRN|rcsb pdb:6DJ9|rcsb pdb:6GH9|rcsb pdb:6GHA|rcsb pdb:6ML1|reactome:R-HSA-2173788|reactome:R-HSA-5689603|reactome:R-HSA-5689880|refseq:NP_006304.1|refseq:NP_001239008.1|refseq:NP_001239007.1|dip:DIP-50239N refseq:NP_001273501.1|refseq:NP_001193962.1|refseq:NP_001193963.1|refseq:NP_055586.1|go:"GO:1900364"(negative regulation of mRNA polyadenylation)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902916"(positive regulation of protein polyubiquitination)|go:"GO:2001168"(positive regulation of histone H2B ubiquitination)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013956(E3 ubiquitin ligase, BRE1)|interpro:IPR017907|mint:O75150|reactome:R-HSA-8866654|go:"GO:0046872"(metal ion binding)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043679"(axon terminus)|go:"GO:0044877"(protein-containing complex binding)|ensembl:ENSG00000103549(gene)|ensembl:ENST00000324685(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0016020"(membrane)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033503"(HULC complex) psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/09/18 rogid:Hjx7D3Eq+fTpjE3D3fUujJN9gW89606 rogid:POkQZhEBe4cw3Y9V3YOwJDgvYJ89606 intact-crc:19BCF0F4A4AEA314|rigid:Z97f0uMdr+tC4vLZ/fcqtuDrCQg false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y4E8 uniprotkb:Q9Y4Z0 intact:EBI-1043104|uniprotkb:Q9HCA6|uniprotkb:Q9UNP0|uniprotkb:Q9Y5B5|ensembl:ENSP00000280377|uniprotkb:Q9H8G9|uniprotkb:Q08AL5 intact:EBI-372521|ensembl:ENSP00000469468 psi-mi:ubp15_human(display_long)|uniprotkb:Unph4(gene name synonym)|uniprotkb:USP15(gene name)|psi-mi:USP15(display_short)|uniprotkb:KIAA0529(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 15(gene name synonym)|uniprotkb:Deubiquitinating enzyme 15(gene name synonym)|uniprotkb:Unph-2(gene name synonym)|uniprotkb:Ubiquitin thioesterase 15(gene name synonym) psi-mi:lsm4_human(display_long)|uniprotkb:Glycine-rich protein(gene name synonym)|uniprotkb:LSM4(gene name)|psi-mi:LSM4(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511673|imex:IM-12079-68 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000135655(gene)|ensembl:ENST00000280377(transcript)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0035520"(monoubiquitinated protein deubiquitination)|go:"GO:0035616"(histone H2B conserved C-terminal lysine deubiquitination)|go:"GO:0042802"(identical protein binding)|go:"GO:0046332"(SMAD binding)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0061649"(ubiquitin modification-dependent histone binding)|go:"GO:1900246"(positive regulation of RIG-I signaling pathway)|go:"GO:1905035"(negative regulation of antifungal innate immune response)|go:"GO:1990167"(protein K27-linked deubiquitination)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR013792(RNA 3'-terminal phosphate cyclase/enolpyruvate transferase, alpha/beta)|interpro:IPR018200|interpro:IPR028135|interpro:IPR028889|interpro:IPR029071|interpro:IPR029346|interpro:IPR035927|interpro:IPR038765|mint:Q9Y4E8|rcsb pdb:1W6V|rcsb pdb:3LMN|rcsb pdb:3PPA|rcsb pdb:3PV1|rcsb pdb:3T9L|rcsb pdb:4A3O|rcsb pdb:4A3P|rcsb pdb:5JJW|rcsb pdb:6CPM|rcsb pdb:6CRN|rcsb pdb:6DJ9|rcsb pdb:6GH9|rcsb pdb:6GHA|rcsb pdb:6ML1|reactome:R-HSA-2173788|reactome:R-HSA-5689603|reactome:R-HSA-5689880|refseq:NP_006304.1|refseq:NP_001239008.1|refseq:NP_001239007.1|dip:DIP-50239N refseq:NP_036453.1|ensembl:ENSG00000130520(gene)|ensembl:ENST00000593829(transcript)|go:"GO:0000387"(spliceosomal snRNP assembly)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000932"(P-body)|go:"GO:0000956"(nuclear-transcribed mRNA catabolic process)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005688"(U6 snRNP)|go:"GO:0005829"(cytosol)|go:"GO:0008380"(RNA splicing)|go:"GO:0016020"(membrane)|go:"GO:0017070"(U6 snRNA binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033962"(P-body assembly)|go:"GO:0042731"(PH domain binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0043005"(neuron projection)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0097526"(spliceosomal tri-snRNP complex)|go:"GO:0120115"(Lsm2-8 complex)|interpro:IPR001163(Like-Sm ribonucleoprotein, core)|interpro:IPR010920(Like-Sm ribonucleoprotein-related, core)|interpro:IPR027141|interpro:IPR034101|rcsb pdb:3JCR|rcsb pdb:5O9Z|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6QW6|rcsb pdb:6QX9|rcsb pdb:7ABG|reactome:R-HSA-430039|reactome:R-HSA-72163|dip:DIP-31209N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/09/18 rogid:Hjx7D3Eq+fTpjE3D3fUujJN9gW89606 rogid:FlaQveuBbixGvfX47pCm26xscT09606 intact-crc:19BCF0F4A4AEA314|rigid:Z97f0uMdr+tC4vLZ/fcqtuDrCQg false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y4E8 uniprotkb:O43447 intact:EBI-1043104|uniprotkb:Q9HCA6|uniprotkb:Q9UNP0|uniprotkb:Q9Y5B5|ensembl:ENSP00000280377|uniprotkb:Q9H8G9|uniprotkb:Q08AL5 intact:EBI-1055615|intact:EBI-6190037|uniprotkb:A6NNE7|ensembl:ENSP00000503384|ensembl:ENSP00000503489|ensembl:ENSP00000503922|ensembl:ENSP00000504108|ensembl:ENSP00000504595|ensembl:ENSP00000361630|ensembl:ENSP00000306614 psi-mi:ubp15_human(display_long)|uniprotkb:Unph4(gene name synonym)|uniprotkb:USP15(gene name)|psi-mi:USP15(display_short)|uniprotkb:KIAA0529(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 15(gene name synonym)|uniprotkb:Deubiquitinating enzyme 15(gene name synonym)|uniprotkb:Unph-2(gene name synonym)|uniprotkb:Ubiquitin thioesterase 15(gene name synonym) psi-mi:ppih_human(display_long)|uniprotkb:U-snRNP-associated cyclophilin SnuCyp-20(gene name synonym)|uniprotkb:Small nuclear ribonucleoprotein particle-specific cyclophilin H(gene name synonym)|uniprotkb:PPIH(gene name)|psi-mi:PPIH(display_short)|uniprotkb:CYP20(gene name synonym)|uniprotkb:CYPH(gene name synonym)|uniprotkb:Rotamase H(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511673|imex:IM-12079-68 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000135655(gene)|ensembl:ENST00000280377(transcript)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0035520"(monoubiquitinated protein deubiquitination)|go:"GO:0035616"(histone H2B conserved C-terminal lysine deubiquitination)|go:"GO:0042802"(identical protein binding)|go:"GO:0046332"(SMAD binding)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0061649"(ubiquitin modification-dependent histone binding)|go:"GO:1900246"(positive regulation of RIG-I signaling pathway)|go:"GO:1905035"(negative regulation of antifungal innate immune response)|go:"GO:1990167"(protein K27-linked deubiquitination)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR013792(RNA 3'-terminal phosphate cyclase/enolpyruvate transferase, alpha/beta)|interpro:IPR018200|interpro:IPR028135|interpro:IPR028889|interpro:IPR029071|interpro:IPR029346|interpro:IPR035927|interpro:IPR038765|mint:Q9Y4E8|rcsb pdb:1W6V|rcsb pdb:3LMN|rcsb pdb:3PPA|rcsb pdb:3PV1|rcsb pdb:3T9L|rcsb pdb:4A3O|rcsb pdb:4A3P|rcsb pdb:5JJW|rcsb pdb:6CPM|rcsb pdb:6CRN|rcsb pdb:6DJ9|rcsb pdb:6GH9|rcsb pdb:6GHA|rcsb pdb:6ML1|reactome:R-HSA-2173788|reactome:R-HSA-5689603|reactome:R-HSA-5689880|refseq:NP_006304.1|refseq:NP_001239008.1|refseq:NP_001239007.1|dip:DIP-50239N refseq:NP_006338.1|refseq:XP_005270419.1|ensembl:ENST00000304979(transcript)|ensembl:ENST00000372550(transcript)|ensembl:ENST00000676675(transcript)|ensembl:ENST00000677900(transcript)|ensembl:ENST00000678038(transcript)|ensembl:ENST00000678333(transcript)|ensembl:ENST00000678803(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006457"(protein folding)|go:"GO:0016018"(cyclosporin A binding)|go:"GO:0016607"(nuclear speck)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071001"(U4/U6 snRNP)|interpro:IPR002130(Peptidyl-prolyl cis-trans isomerase, cyclophilin-type)|interpro:IPR020892|interpro:IPR024936|interpro:IPR029000|mint:O43447|rcsb pdb:1MZW|rcsb pdb:1QOI|rcsb pdb:5O9Z|rcsb pdb:6AHD|reactome:R-HSA-72163|ensembl:ENSG00000171960(gene)|refseq:NP_001317439.1|refseq:XP_016855546.1|refseq:XP_016855547.1|refseq:XP_016855548.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/09/18 rogid:Hjx7D3Eq+fTpjE3D3fUujJN9gW89606 rogid:6gE98w/LLmT7FlCBnaBDk+GWvQU9606 intact-crc:19BCF0F4A4AEA314|rigid:Z97f0uMdr+tC4vLZ/fcqtuDrCQg false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y4E8 uniprotkb:Q9Y623 intact:EBI-1043104|uniprotkb:Q9HCA6|uniprotkb:Q9UNP0|uniprotkb:Q9Y5B5|ensembl:ENSP00000280377|uniprotkb:Q9H8G9|uniprotkb:Q08AL5 intact:EBI-2511704|ensembl:ENSP00000255381 psi-mi:ubp15_human(display_long)|uniprotkb:Unph4(gene name synonym)|uniprotkb:USP15(gene name)|psi-mi:USP15(display_short)|uniprotkb:KIAA0529(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 15(gene name synonym)|uniprotkb:Deubiquitinating enzyme 15(gene name synonym)|uniprotkb:Unph-2(gene name synonym)|uniprotkb:Ubiquitin thioesterase 15(gene name synonym) psi-mi:myh4_human(display_long)|uniprotkb:MYH4(gene name)|psi-mi:MYH4(display_short)|uniprotkb:Myosin heavy chain 4(gene name synonym)|uniprotkb:Myosin heavy chain 2b(gene name synonym)|uniprotkb:Myosin heavy chain IIb(gene name synonym)|uniprotkb:Myosin heavy chain, skeletal muscle, fetal(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511673|imex:IM-12079-68 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000135655(gene)|ensembl:ENST00000280377(transcript)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0035520"(monoubiquitinated protein deubiquitination)|go:"GO:0035616"(histone H2B conserved C-terminal lysine deubiquitination)|go:"GO:0042802"(identical protein binding)|go:"GO:0046332"(SMAD binding)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0061649"(ubiquitin modification-dependent histone binding)|go:"GO:1900246"(positive regulation of RIG-I signaling pathway)|go:"GO:1905035"(negative regulation of antifungal innate immune response)|go:"GO:1990167"(protein K27-linked deubiquitination)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR013792(RNA 3'-terminal phosphate cyclase/enolpyruvate transferase, alpha/beta)|interpro:IPR018200|interpro:IPR028135|interpro:IPR028889|interpro:IPR029071|interpro:IPR029346|interpro:IPR035927|interpro:IPR038765|mint:Q9Y4E8|rcsb pdb:1W6V|rcsb pdb:3LMN|rcsb pdb:3PPA|rcsb pdb:3PV1|rcsb pdb:3T9L|rcsb pdb:4A3O|rcsb pdb:4A3P|rcsb pdb:5JJW|rcsb pdb:6CPM|rcsb pdb:6CRN|rcsb pdb:6DJ9|rcsb pdb:6GH9|rcsb pdb:6GHA|rcsb pdb:6ML1|reactome:R-HSA-2173788|reactome:R-HSA-5689603|reactome:R-HSA-5689880|refseq:NP_006304.1|refseq:NP_001239008.1|refseq:NP_001239007.1|dip:DIP-50239N ensembl:ENSG00000264424(gene)|ensembl:ENST00000255381(transcript)|go:"GO:0000146"(microfilament motor activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0006936"(muscle contraction)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0030016"(myofibril)|go:"GO:0030017"(sarcomere)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0030049"(muscle filament sliding)|go:"GO:0032982"(myosin filament)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0051015"(actin filament binding)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR001609(Myosin head, motor region)|interpro:IPR002928(Myosin tail)|interpro:IPR004009(Myosin, N-terminal, SH3-like)|interpro:IPR008989(Myosin S1 fragment, N-terminal)|interpro:IPR014751(DNA double-strand break repair and VJ recombination XRCC4, C-terminal)|interpro:IPR027417|interpro:IPR036961|go:"GO:0005859"(muscle myosin complex)|refseq:NP_060003.2|refseq:XP_016880165.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/09/18 rogid:Hjx7D3Eq+fTpjE3D3fUujJN9gW89606 rogid:7zD8Mcq4iGSoiy7hj6AyKDzesRQ9606 intact-crc:19BCF0F4A4AEA314|rigid:Z97f0uMdr+tC4vLZ/fcqtuDrCQg false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y4E8 uniprotkb:Q15323 intact:EBI-1043104|uniprotkb:Q9HCA6|uniprotkb:Q9UNP0|uniprotkb:Q9Y5B5|ensembl:ENSP00000280377|uniprotkb:Q9H8G9|uniprotkb:Q08AL5 intact:EBI-948001|uniprotkb:Q9UE12|ensembl:ENSP00000251645|ensembl:ENSP00000460739 psi-mi:ubp15_human(display_long)|uniprotkb:Unph4(gene name synonym)|uniprotkb:USP15(gene name)|psi-mi:USP15(display_short)|uniprotkb:KIAA0529(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 15(gene name synonym)|uniprotkb:Deubiquitinating enzyme 15(gene name synonym)|uniprotkb:Unph-2(gene name synonym)|uniprotkb:Ubiquitin thioesterase 15(gene name synonym) psi-mi:k1h1_human(display_long)|uniprotkb:Hair keratin, type I Ha1(gene name synonym)|uniprotkb:Keratin-31(gene name synonym)|uniprotkb:KRT31(gene name)|psi-mi:KRT31(display_short)|uniprotkb:HHA1(gene name synonym)|uniprotkb:HKA1(gene name synonym)|uniprotkb:KRTHA1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511673|imex:IM-12079-68 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000135655(gene)|ensembl:ENST00000280377(transcript)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0035520"(monoubiquitinated protein deubiquitination)|go:"GO:0035616"(histone H2B conserved C-terminal lysine deubiquitination)|go:"GO:0042802"(identical protein binding)|go:"GO:0046332"(SMAD binding)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0061649"(ubiquitin modification-dependent histone binding)|go:"GO:1900246"(positive regulation of RIG-I signaling pathway)|go:"GO:1905035"(negative regulation of antifungal innate immune response)|go:"GO:1990167"(protein K27-linked deubiquitination)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR013792(RNA 3'-terminal phosphate cyclase/enolpyruvate transferase, alpha/beta)|interpro:IPR018200|interpro:IPR028135|interpro:IPR028889|interpro:IPR029071|interpro:IPR029346|interpro:IPR035927|interpro:IPR038765|mint:Q9Y4E8|rcsb pdb:1W6V|rcsb pdb:3LMN|rcsb pdb:3PPA|rcsb pdb:3PV1|rcsb pdb:3T9L|rcsb pdb:4A3O|rcsb pdb:4A3P|rcsb pdb:5JJW|rcsb pdb:6CPM|rcsb pdb:6CRN|rcsb pdb:6DJ9|rcsb pdb:6GH9|rcsb pdb:6GHA|rcsb pdb:6ML1|reactome:R-HSA-2173788|reactome:R-HSA-5689603|reactome:R-HSA-5689880|refseq:NP_006304.1|refseq:NP_001239008.1|refseq:NP_001239007.1|dip:DIP-50239N refseq:NP_002268.2|ensembl:ENSG00000094796(gene)|ensembl:ENSG00000262993(gene)|ensembl:ENST00000251645(transcript)|ensembl:ENST00000573281(transcript)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005615"(extracellular space)|go:"GO:0005829"(cytosol)|go:"GO:0005882"(intermediate filament)|go:"GO:0008544"(epidermis development)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002957(Keratin, type I)|interpro:IPR018039|interpro:IPR039008|reactome:R-HSA-6805567|reactome:R-HSA-6809371 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/09/18 rogid:Hjx7D3Eq+fTpjE3D3fUujJN9gW89606 rogid:ur97LEvtqaqu3wh7iaX4HhN163k9606 intact-crc:19BCF0F4A4AEA314|rigid:Z97f0uMdr+tC4vLZ/fcqtuDrCQg false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q0WX57 uniprotkb:Q99538 intact:EBI-2511781|ensembl:ENSP00000422097|ensembl:ENSP00000422887|ensembl:ENSP00000422969|ensembl:ENSP00000423211|ensembl:ENSP00000423777|ensembl:ENSP00000425375|ensembl:ENSP00000427366|uniprotkb:Q0WX56|uniprotkb:A8MRA9|uniprotkb:Q3BEM1 intact:EBI-2511794|ensembl:ENSP00000334052|ensembl:ENSP00000376911|uniprotkb:Q86TV2|uniprotkb:Q86TV3|uniprotkb:Q9BTY1|uniprotkb:O00123|intact:EBI-10963477 psi-mi:u17lo_human(display_long)|uniprotkb:USP17(gene name synonym)|uniprotkb:USP17L24(gene name)|psi-mi:USP17L24(display_short)|uniprotkb:USP17L25(gene name)|psi-mi:USP17L25(display_short)|uniprotkb:USP17L26(gene name)|psi-mi:USP17L26(display_short)|uniprotkb:USP17L27(gene name)|psi-mi:USP17L27(display_short)|uniprotkb:USP17L28(gene name)|psi-mi:USP17L28(display_short)|uniprotkb:USP17L29(gene name)|psi-mi:USP17L29(display_short)|uniprotkb:USP17L30(gene name)|psi-mi:USP17L30(display_short)|uniprotkb:Deubiquitinating enzyme 17(gene name synonym)|uniprotkb:USP17H(gene name synonym)|uniprotkb:USP17I(gene name synonym)|uniprotkb:USP17J(gene name synonym)|uniprotkb:USP17K(gene name synonym)|uniprotkb:USP17L(gene name synonym)|uniprotkb:USP17M(gene name synonym)|uniprotkb:Ubiquitin thioesterase 17(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 17(gene name synonym) psi-mi:lgmn_human(display_long)|uniprotkb:LGMN(gene name)|psi-mi:LGMN(display_short)|uniprotkb:PRSC1(gene name synonym)|uniprotkb:Asparaginyl endopeptidase(gene name synonym)|uniprotkb:Protease, cysteine 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511800|imex:IM-12079-18 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000228856(gene)|ensembl:ENSG00000229579(gene)|ensembl:ENSG00000230430(gene)|ensembl:ENSG00000231051(gene)|ensembl:ENSG00000231637(gene)|ensembl:ENSG00000232264(gene)|ensembl:ENSG00000235780(gene)|ensembl:ENST00000504104(transcript)|ensembl:ENST00000504481(transcript)|ensembl:ENST00000504543(transcript)|ensembl:ENST00000509271(transcript)|ensembl:ENST00000509660(transcript)|ensembl:ENST00000511681(transcript)|ensembl:ENST00000515574(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005540"(hyaluronic acid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0071947"(protein deubiquitination involved in ubiquitin-dependent protein catabolic process)|go:"GO:1904037"(positive regulation of epithelial cell apoptotic process)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR006861(Hyaluronan/mRNA binding protein)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|reactome:R-HSA-5689880|refseq:NP_001229255.1|refseq:NP_001229256.1|refseq:NP_001229257.1|refseq:NP_001229259.1|refseq:NP_001229260.1|refseq:NP_001229261.1|refseq:NP_001243796.1 ensembl:ENSG00000100600(gene)|ensembl:ENST00000334869(transcript)|ensembl:ENST00000393218(transcript)|go:"GO:0003014"(renal system process)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0006508"(proteolysis)|go:"GO:0006624"(vacuolar protein processing)|go:"GO:0007613"(memory)|go:"GO:0008233"(peptidase activity)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008306"(associative learning)|go:"GO:0010447"(response to acidic pH)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0036021"(endolysosome lumen)|go:"GO:0042359"(vitamin D metabolic process)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045177"(apical part of cell)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0097061"(dendritic spine organization)|go:"GO:0097202"(activation of cysteine-type endopeptidase activity)|go:"GO:0097264"(self proteolysis)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1901185"(negative regulation of ERBB signaling pathway)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:2001028"(positive regulation of endothelial cell chemotaxis)|interpro:IPR001096(Peptidase C13, legumain)|interpro:IPR043577|mint:Q99538|rcsb pdb:4AW9|rcsb pdb:4AWA|rcsb pdb:4AWB|rcsb pdb:4FGU|rcsb pdb:4N6N|rcsb pdb:4N6O|rcsb pdb:5LU8|rcsb pdb:5LU9|rcsb pdb:5LUA|rcsb pdb:5LUB|reactome:R-HSA-1679131|go:"GO:0040015"(negative regulation of multicellular organism growth)|reactome:R-HSA-196791|reactome:R-HSA-2132295|refseq:XP_005267919.1|refseq:XP_005267920.1|refseq:NP_001008530.1|refseq:NP_005597.3|refseq:XP_016876952.1|refseq:XP_016876953.1|refseq:XP_016876954.1|refseq:XP_016876955.1|refseq:XP_016876956.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:W9ID/XWR8RGNrH267F2ooi5zsJ89606 rogid:W2jPq8/peH5iXt1wmbm8lFnkJwM9606 intact-crc:2727405F833F8348|rigid:h3mxxLp+6QM1+n/MclpOLs3ckGQ false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q0WX57 uniprotkb:Q9BZK3 intact:EBI-2511781|ensembl:ENSP00000422097|ensembl:ENSP00000422887|ensembl:ENSP00000422969|ensembl:ENSP00000423211|ensembl:ENSP00000423777|ensembl:ENSP00000425375|ensembl:ENSP00000427366|uniprotkb:Q0WX56|uniprotkb:A8MRA9|uniprotkb:Q3BEM1 intact:EBI-1044076 psi-mi:u17lo_human(display_long)|uniprotkb:USP17(gene name synonym)|uniprotkb:USP17L24(gene name)|psi-mi:USP17L24(display_short)|uniprotkb:USP17L25(gene name)|psi-mi:USP17L25(display_short)|uniprotkb:USP17L26(gene name)|psi-mi:USP17L26(display_short)|uniprotkb:USP17L27(gene name)|psi-mi:USP17L27(display_short)|uniprotkb:USP17L28(gene name)|psi-mi:USP17L28(display_short)|uniprotkb:USP17L29(gene name)|psi-mi:USP17L29(display_short)|uniprotkb:USP17L30(gene name)|psi-mi:USP17L30(display_short)|uniprotkb:Deubiquitinating enzyme 17(gene name synonym)|uniprotkb:USP17H(gene name synonym)|uniprotkb:USP17I(gene name synonym)|uniprotkb:USP17J(gene name synonym)|uniprotkb:USP17K(gene name synonym)|uniprotkb:USP17L(gene name synonym)|uniprotkb:USP17M(gene name synonym)|uniprotkb:Ubiquitin thioesterase 17(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 17(gene name synonym) psi-mi:nacp4_human(display_long)|uniprotkb:NACA4P(gene name)|psi-mi:NACA4P(display_short)|uniprotkb:Alpha-NAC pseudogene 1(gene name synonym)|uniprotkb:NAC-alpha pseudogene 1(gene name synonym)|uniprotkb:NACA family member 4, pseudogene(gene name synonym)|uniprotkb:NACAP1(gene name synonym)|uniprotkb:FKSG17(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511800|imex:IM-12079-18 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000228856(gene)|ensembl:ENSG00000229579(gene)|ensembl:ENSG00000230430(gene)|ensembl:ENSG00000231051(gene)|ensembl:ENSG00000231637(gene)|ensembl:ENSG00000232264(gene)|ensembl:ENSG00000235780(gene)|ensembl:ENST00000504104(transcript)|ensembl:ENST00000504481(transcript)|ensembl:ENST00000504543(transcript)|ensembl:ENST00000509271(transcript)|ensembl:ENST00000509660(transcript)|ensembl:ENST00000511681(transcript)|ensembl:ENST00000515574(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005540"(hyaluronic acid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0071947"(protein deubiquitination involved in ubiquitin-dependent protein catabolic process)|go:"GO:1904037"(positive regulation of epithelial cell apoptotic process)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR006861(Hyaluronan/mRNA binding protein)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|reactome:R-HSA-5689880|refseq:NP_001229255.1|refseq:NP_001229256.1|refseq:NP_001229257.1|refseq:NP_001229259.1|refseq:NP_001229260.1|refseq:NP_001229261.1|refseq:NP_001243796.1 interpro:IPR002715(Nascent polypeptide-associated complex NAC)|interpro:IPR016641(Nascent polypeptide-associated complex, alpha subunit)|go:"GO:0005737"(cytoplasm)|go:"GO:0005854"(nascent polypeptide-associated complex)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0051082"(unfolded protein binding)|mint:Q9BZK3|interpro:IPR038187 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:W9ID/XWR8RGNrH267F2ooi5zsJ89606 rogid:IvQD8+pUywszW7K0TJde4MxPzuk9606 intact-crc:2727405F833F8348|rigid:h3mxxLp+6QM1+n/MclpOLs3ckGQ false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q0WX57 uniprotkb:Q6R6M4 intact:EBI-2511781|ensembl:ENSP00000422097|ensembl:ENSP00000422887|ensembl:ENSP00000422969|ensembl:ENSP00000423211|ensembl:ENSP00000423777|ensembl:ENSP00000425375|ensembl:ENSP00000427366|uniprotkb:Q0WX56|uniprotkb:A8MRA9|uniprotkb:Q3BEM1 intact:EBI-2511810|ensembl:ENSP00000333329 psi-mi:u17lo_human(display_long)|uniprotkb:USP17(gene name synonym)|uniprotkb:USP17L24(gene name)|psi-mi:USP17L24(display_short)|uniprotkb:USP17L25(gene name)|psi-mi:USP17L25(display_short)|uniprotkb:USP17L26(gene name)|psi-mi:USP17L26(display_short)|uniprotkb:USP17L27(gene name)|psi-mi:USP17L27(display_short)|uniprotkb:USP17L28(gene name)|psi-mi:USP17L28(display_short)|uniprotkb:USP17L29(gene name)|psi-mi:USP17L29(display_short)|uniprotkb:USP17L30(gene name)|psi-mi:USP17L30(display_short)|uniprotkb:Deubiquitinating enzyme 17(gene name synonym)|uniprotkb:USP17H(gene name synonym)|uniprotkb:USP17I(gene name synonym)|uniprotkb:USP17J(gene name synonym)|uniprotkb:USP17K(gene name synonym)|uniprotkb:USP17L(gene name synonym)|uniprotkb:USP17M(gene name synonym)|uniprotkb:Ubiquitin thioesterase 17(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 17(gene name synonym) psi-mi:u17l2_human(display_long)|uniprotkb:USP17L2(gene name)|psi-mi:USP17L2(display_short)|uniprotkb:DUB3(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 17-like protein 2(gene name synonym)|uniprotkb:Deubiquitinating enzyme 17-like protein 2(gene name synonym)|uniprotkb:Deubiquitinating protein 3(gene name synonym)|uniprotkb:USP17(gene name synonym)|uniprotkb:USP17H(gene name synonym)|uniprotkb:USP17I(gene name synonym)|uniprotkb:USP17J(gene name synonym)|uniprotkb:USP17K(gene name synonym)|uniprotkb:USP17L(gene name synonym)|uniprotkb:USP17M(gene name synonym)|uniprotkb:Ubiquitin carboxyl-terminal hydrolase 17-like protein 2(gene name synonym)|uniprotkb:Ubiquitin thioesterase 17-like protein 2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511800|imex:IM-12079-18 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000228856(gene)|ensembl:ENSG00000229579(gene)|ensembl:ENSG00000230430(gene)|ensembl:ENSG00000231051(gene)|ensembl:ENSG00000231637(gene)|ensembl:ENSG00000232264(gene)|ensembl:ENSG00000235780(gene)|ensembl:ENST00000504104(transcript)|ensembl:ENST00000504481(transcript)|ensembl:ENST00000504543(transcript)|ensembl:ENST00000509271(transcript)|ensembl:ENST00000509660(transcript)|ensembl:ENST00000511681(transcript)|ensembl:ENST00000515574(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005540"(hyaluronic acid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0071947"(protein deubiquitination involved in ubiquitin-dependent protein catabolic process)|go:"GO:1904037"(positive regulation of epithelial cell apoptotic process)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR006861(Hyaluronan/mRNA binding protein)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|reactome:R-HSA-5689880|refseq:NP_001229255.1|refseq:NP_001229256.1|refseq:NP_001229257.1|refseq:NP_001229259.1|refseq:NP_001229260.1|refseq:NP_001229261.1|refseq:NP_001243796.1 ensembl:ENSG00000223443(gene)|ensembl:ENST00000333796(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0010955"(negative regulation of protein processing)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0031064"(negative regulation of histone deacetylation)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0050691"(regulation of defense response to virus by host)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:0071586"(CAAX-box protein processing)|go:"GO:0110030"(regulation of G2/MI transition of meiotic cell cycle)|go:"GO:1900027"(regulation of ruffle assembly)|go:"GO:1900245"(positive regulation of MDA-5 signaling pathway)|go:"GO:1900246"(positive regulation of RIG-I signaling pathway)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|reactome:R-HSA-5689880|reactome:R-HSA-9648002|go:"GO:0090315"(negative regulation of protein targeting to membrane)|refseq:NP_958804.2 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:W9ID/XWR8RGNrH267F2ooi5zsJ89606 rogid:ECUDXiuY+fF/Se+hz7Y9ZVX0y/A9606 intact-crc:2727405F833F8348|rigid:h3mxxLp+6QM1+n/MclpOLs3ckGQ false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q0WX57 uniprotkb:P20290 intact:EBI-2511781|ensembl:ENSP00000422097|ensembl:ENSP00000422887|ensembl:ENSP00000422969|ensembl:ENSP00000423211|ensembl:ENSP00000423777|ensembl:ENSP00000425375|ensembl:ENSP00000427366|uniprotkb:Q0WX56|uniprotkb:A8MRA9|uniprotkb:Q3BEM1 intact:EBI-1054687|uniprotkb:Q13893|uniprotkb:Q76M56|uniprotkb:A8K510|ensembl:ENSP00000369965 psi-mi:u17lo_human(display_long)|uniprotkb:USP17(gene name synonym)|uniprotkb:USP17L24(gene name)|psi-mi:USP17L24(display_short)|uniprotkb:USP17L25(gene name)|psi-mi:USP17L25(display_short)|uniprotkb:USP17L26(gene name)|psi-mi:USP17L26(display_short)|uniprotkb:USP17L27(gene name)|psi-mi:USP17L27(display_short)|uniprotkb:USP17L28(gene name)|psi-mi:USP17L28(display_short)|uniprotkb:USP17L29(gene name)|psi-mi:USP17L29(display_short)|uniprotkb:USP17L30(gene name)|psi-mi:USP17L30(display_short)|uniprotkb:Deubiquitinating enzyme 17(gene name synonym)|uniprotkb:USP17H(gene name synonym)|uniprotkb:USP17I(gene name synonym)|uniprotkb:USP17J(gene name synonym)|uniprotkb:USP17K(gene name synonym)|uniprotkb:USP17L(gene name synonym)|uniprotkb:USP17M(gene name synonym)|uniprotkb:Ubiquitin thioesterase 17(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 17(gene name synonym) psi-mi:btf3_human(display_long)|uniprotkb:RNA polymerase B transcription factor 3(gene name synonym)|uniprotkb:BTF3(gene name)|psi-mi:BTF3(display_short)|uniprotkb:NACB(gene name synonym)|uniprotkb:OK/SW-cl.8(orf name)|uniprotkb:Nascent polypeptide-associated complex subunit beta(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511800|imex:IM-12079-18 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000228856(gene)|ensembl:ENSG00000229579(gene)|ensembl:ENSG00000230430(gene)|ensembl:ENSG00000231051(gene)|ensembl:ENSG00000231637(gene)|ensembl:ENSG00000232264(gene)|ensembl:ENSG00000235780(gene)|ensembl:ENST00000504104(transcript)|ensembl:ENST00000504481(transcript)|ensembl:ENST00000504543(transcript)|ensembl:ENST00000509271(transcript)|ensembl:ENST00000509660(transcript)|ensembl:ENST00000511681(transcript)|ensembl:ENST00000515574(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005540"(hyaluronic acid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0071947"(protein deubiquitination involved in ubiquitin-dependent protein catabolic process)|go:"GO:1904037"(positive regulation of epithelial cell apoptotic process)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR006861(Hyaluronan/mRNA binding protein)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|reactome:R-HSA-5689880|refseq:NP_001229255.1|refseq:NP_001229256.1|refseq:NP_001229257.1|refseq:NP_001229259.1|refseq:NP_001229260.1|refseq:NP_001229261.1|refseq:NP_001243796.1 refseq:NP_001032726.1|refseq:NP_001198.2|ensembl:ENSG00000145741(gene)|ensembl:ENST00000380591(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005854"(nascent polypeptide-associated complex)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0015031"(protein transport)|go:"GO:0042788"(polysomal ribosome)|interpro:IPR002715(Nascent polypeptide-associated complex NAC)|interpro:IPR038187|interpro:IPR039370|mint:P20290|rcsb pdb:3LKX|rcsb pdb:3MCB psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:W9ID/XWR8RGNrH267F2ooi5zsJ89606 rogid:TU7PtK2KVrzmdfaTdWcHloiRZYg9606 intact-crc:2727405F833F8348|rigid:h3mxxLp+6QM1+n/MclpOLs3ckGQ false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q0WX57 uniprotkb:P0C7H9 intact:EBI-2511781|ensembl:ENSP00000422097|ensembl:ENSP00000422887|ensembl:ENSP00000422969|ensembl:ENSP00000423211|ensembl:ENSP00000423777|ensembl:ENSP00000425375|ensembl:ENSP00000427366|uniprotkb:Q0WX56|uniprotkb:A8MRA9|uniprotkb:Q3BEM1 intact:EBI-2511777|ensembl:ENSP00000485337 psi-mi:u17lo_human(display_long)|uniprotkb:USP17(gene name synonym)|uniprotkb:USP17L24(gene name)|psi-mi:USP17L24(display_short)|uniprotkb:USP17L25(gene name)|psi-mi:USP17L25(display_short)|uniprotkb:USP17L26(gene name)|psi-mi:USP17L26(display_short)|uniprotkb:USP17L27(gene name)|psi-mi:USP17L27(display_short)|uniprotkb:USP17L28(gene name)|psi-mi:USP17L28(display_short)|uniprotkb:USP17L29(gene name)|psi-mi:USP17L29(display_short)|uniprotkb:USP17L30(gene name)|psi-mi:USP17L30(display_short)|uniprotkb:Deubiquitinating enzyme 17(gene name synonym)|uniprotkb:USP17H(gene name synonym)|uniprotkb:USP17I(gene name synonym)|uniprotkb:USP17J(gene name synonym)|uniprotkb:USP17K(gene name synonym)|uniprotkb:USP17L(gene name synonym)|uniprotkb:USP17M(gene name synonym)|uniprotkb:Ubiquitin thioesterase 17(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 17(gene name synonym) psi-mi:u17l7_human(display_long)|uniprotkb:USP17L7(gene name)|psi-mi:USP17L7(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511800|imex:IM-12079-18 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000228856(gene)|ensembl:ENSG00000229579(gene)|ensembl:ENSG00000230430(gene)|ensembl:ENSG00000231051(gene)|ensembl:ENSG00000231637(gene)|ensembl:ENSG00000232264(gene)|ensembl:ENSG00000235780(gene)|ensembl:ENST00000504104(transcript)|ensembl:ENST00000504481(transcript)|ensembl:ENST00000504543(transcript)|ensembl:ENST00000509271(transcript)|ensembl:ENST00000509660(transcript)|ensembl:ENST00000511681(transcript)|ensembl:ENST00000515574(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005540"(hyaluronic acid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0071947"(protein deubiquitination involved in ubiquitin-dependent protein catabolic process)|go:"GO:1904037"(positive regulation of epithelial cell apoptotic process)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR006861(Hyaluronan/mRNA binding protein)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|reactome:R-HSA-5689880|refseq:NP_001229255.1|refseq:NP_001229256.1|refseq:NP_001229257.1|refseq:NP_001229259.1|refseq:NP_001229260.1|refseq:NP_001229261.1|refseq:NP_001243796.1 ensembl:ENSG00000226430(gene)|ensembl:ENST00000530447(transcript)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0042981"(regulation of apoptotic process)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|refseq:NP_001243798.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:W9ID/XWR8RGNrH267F2ooi5zsJ89606 rogid:eT+zdD3jiYQz3wkFFcifYzKnREw9606 intact-crc:2727405F833F8348|rigid:h3mxxLp+6QM1+n/MclpOLs3ckGQ false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q0WX57 uniprotkb:Q9UHI8 intact:EBI-2511781|ensembl:ENSP00000422097|ensembl:ENSP00000422887|ensembl:ENSP00000422969|ensembl:ENSP00000423211|ensembl:ENSP00000423777|ensembl:ENSP00000425375|ensembl:ENSP00000427366|uniprotkb:Q0WX56|uniprotkb:A8MRA9|uniprotkb:Q3BEM1 intact:EBI-2511802|ensembl:ENSP00000284984|uniprotkb:Q9NSJ8|uniprotkb:Q9UP80|uniprotkb:Q9UH83|uniprotkb:Q9P2K0|uniprotkb:D3DSD5 psi-mi:u17lo_human(display_long)|uniprotkb:USP17(gene name synonym)|uniprotkb:USP17L24(gene name)|psi-mi:USP17L24(display_short)|uniprotkb:USP17L25(gene name)|psi-mi:USP17L25(display_short)|uniprotkb:USP17L26(gene name)|psi-mi:USP17L26(display_short)|uniprotkb:USP17L27(gene name)|psi-mi:USP17L27(display_short)|uniprotkb:USP17L28(gene name)|psi-mi:USP17L28(display_short)|uniprotkb:USP17L29(gene name)|psi-mi:USP17L29(display_short)|uniprotkb:USP17L30(gene name)|psi-mi:USP17L30(display_short)|uniprotkb:Deubiquitinating enzyme 17(gene name synonym)|uniprotkb:USP17H(gene name synonym)|uniprotkb:USP17I(gene name synonym)|uniprotkb:USP17J(gene name synonym)|uniprotkb:USP17K(gene name synonym)|uniprotkb:USP17L(gene name synonym)|uniprotkb:USP17M(gene name synonym)|uniprotkb:Ubiquitin thioesterase 17(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 17(gene name synonym) psi-mi:ats1_human(display_long)|uniprotkb:ADAMTS1(gene name)|psi-mi:ADAMTS1(display_short)|uniprotkb:KIAA1346(gene name synonym)|uniprotkb:METH1(gene name synonym)|uniprotkb:METH-1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511800|imex:IM-12079-18 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000228856(gene)|ensembl:ENSG00000229579(gene)|ensembl:ENSG00000230430(gene)|ensembl:ENSG00000231051(gene)|ensembl:ENSG00000231637(gene)|ensembl:ENSG00000232264(gene)|ensembl:ENSG00000235780(gene)|ensembl:ENST00000504104(transcript)|ensembl:ENST00000504481(transcript)|ensembl:ENST00000504543(transcript)|ensembl:ENST00000509271(transcript)|ensembl:ENST00000509660(transcript)|ensembl:ENST00000511681(transcript)|ensembl:ENST00000515574(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005540"(hyaluronic acid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0071947"(protein deubiquitination involved in ubiquitin-dependent protein catabolic process)|go:"GO:1904037"(positive regulation of epithelial cell apoptotic process)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR006861(Hyaluronan/mRNA binding protein)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|reactome:R-HSA-5689880|refseq:NP_001229255.1|refseq:NP_001229256.1|refseq:NP_001229257.1|refseq:NP_001229259.1|refseq:NP_001229260.1|refseq:NP_001229261.1|refseq:NP_001243796.1 ensembl:ENSG00000154734(gene)|ensembl:ENST00000284984(transcript)|go:"GO:0001542"(ovulation from ovarian follicle)|go:"GO:0001822"(kidney development)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008201"(heparin binding)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0060347"(heart trabecula formation)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|interpro:IPR000884(Thrombospondin, type I)|interpro:IPR001590(Peptidase M12B, ADAM/reprolysin)|interpro:IPR002870(Peptidase M12B, propeptide)|interpro:IPR006586(ADAM, cysteine-rich)|interpro:IPR010294(ADAM-TS Spacer 1)|interpro:IPR013273(Peptidase M12B, ADAM-TS)|interpro:IPR013274(Peptidase M12B, ADAM-TS1)|interpro:IPR024079|interpro:IPR036383|interpro:IPR041645|rcsb pdb:2JIH|rcsb pdb:2V4B|rcsb pdb:3Q2G|rcsb pdb:3Q2H|reactome:R-HSA-1474228|reactome:R-HSA-5083635|reactome:R-HSA-5173214|refseq:NP_008919.3 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:W9ID/XWR8RGNrH267F2ooi5zsJ89606 rogid:/2rwfNnTU6Seo5+ZZdGeEEUeoAQ9606 intact-crc:2727405F833F8348|rigid:h3mxxLp+6QM1+n/MclpOLs3ckGQ false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UMW8 uniprotkb:Q3LFD5 intact:EBI-356206|uniprotkb:Q9NY71|uniprotkb:Q6IAD9|ensembl:ENSP00000215794|uniprotkb:Q53Y90 intact:EBI-2511843|uniprotkb:A8MXD0|uniprotkb:Q70BM7 psi-mi:ubp18_human(display_long)|uniprotkb:USP18(gene name)|psi-mi:USP18(display_short)|uniprotkb:ISG43(gene name synonym)|uniprotkb:ISG15-specific-processing protease(gene name synonym)|uniprotkb:43 kDa ISG15-specific protease(gene name synonym)|uniprotkb:Ubl thioesterase 18(gene name synonym) psi-mi:ubp41_human(display_long)|uniprotkb:USP41(gene name)|psi-mi:USP41(display_short)|uniprotkb:Ubiquitin-specific-processing protease 41(gene name synonym)|uniprotkb:Deubiquitinating enzyme 41(gene name synonym)|uniprotkb:Ubiquitin thioesterase 41(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511849|imex:IM-12079-69 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_059110.2|ensembl:ENSG00000184979(gene)|ensembl:ENST00000215794(transcript)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019785"(ISG15-specific protease activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0060339"(negative regulation of type I interferon-mediated signaling pathway)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|mint:Q9UMW8|reactome:R-HSA-1169408|reactome:R-HSA-5689880|reactome:R-HSA-912694|dip:DIP-42723N go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|interpro:IPR028889|interpro:IPR018200|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|reactome:R-HSA-1169408|interpro:IPR038765 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:f8gp0LV11CoEQvSGwbUVMEwRd+U9606 rogid:t6Qvd6O/rZGKIe/BhBNHwoCl3WI9606 intact-crc:1E90225B79FB74F4|rigid:U8iHQe3l4LJoZ+SJrP4LNPQtGBU false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UMW8 uniprotkb:P15531 intact:EBI-356206|uniprotkb:Q9NY71|uniprotkb:Q6IAD9|ensembl:ENSP00000215794|uniprotkb:Q53Y90 intact:EBI-741141|ensembl:ENSP00000376892|uniprotkb:Q6FGK3|uniprotkb:Q86XQ2|uniprotkb:Q9UDJ6 psi-mi:ubp18_human(display_long)|uniprotkb:USP18(gene name)|psi-mi:USP18(display_short)|uniprotkb:ISG43(gene name synonym)|uniprotkb:ISG15-specific-processing protease(gene name synonym)|uniprotkb:43 kDa ISG15-specific protease(gene name synonym)|uniprotkb:Ubl thioesterase 18(gene name synonym) psi-mi:ndka_human(display_long)|uniprotkb:Tumor metastatic process-associated protein(gene name synonym)|uniprotkb:Metastasis inhibition factor nm23(gene name synonym)|uniprotkb:Granzyme A-activated DNase(gene name synonym)|uniprotkb:NME1(gene name)|psi-mi:NME1(display_short)|uniprotkb:NDPKA(gene name synonym)|uniprotkb:NM23(gene name synonym)|uniprotkb:NM23-H1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511849|imex:IM-12079-69 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_059110.2|ensembl:ENSG00000184979(gene)|ensembl:ENST00000215794(transcript)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019785"(ISG15-specific protease activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0060339"(negative regulation of type I interferon-mediated signaling pathway)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|mint:Q9UMW8|reactome:R-HSA-1169408|reactome:R-HSA-5689880|reactome:R-HSA-912694|dip:DIP-42723N refseq:NP_000260.1|refseq:NP_937818.1|ensembl:ENSG00000239672(gene)|ensembl:ENST00000393196(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0002762"(negative regulation of myeloid leukocyte differentiation)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004536"(deoxyribonuclease activity)|go:"GO:0004550"(nucleoside diphosphate kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005882"(intermediate filament)|go:"GO:0006183"(GTP biosynthetic process)|go:"GO:0006228"(UTP biosynthetic process)|go:"GO:0006241"(CTP biosynthetic process)|go:"GO:0006897"(endocytosis)|go:"GO:0007595"(lactation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014075"(response to amine)|go:"GO:0016020"(membrane)|go:"GO:0019215"(intermediate filament binding)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051591"(response to cAMP)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071398"(cellular response to fatty acid)|interpro:IPR001564(Nucleoside diphosphate kinase, core)|go:"GO:0019899"(enzyme binding)|interpro:IPR023005|go:"GO:0021766"(hippocampus development)|interpro:IPR034907|interpro:IPR036850|mint:P15531|go:"GO:0030154"(cell differentiation)|go:"GO:0032587"(ruffle membrane)|rcsb pdb:1JXV|rcsb pdb:1UCN|go:"GO:0033574"(response to testosterone)|go:"GO:0035690"|rcsb pdb:2HVD|rcsb pdb:2HVE|rcsb pdb:3L7U|rcsb pdb:4ENO|rcsb pdb:5UI4|reactome:R-HSA-499943|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043024"(ribosomal small subunit binding)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|dip:DIP-39164N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:f8gp0LV11CoEQvSGwbUVMEwRd+U9606 rogid:Ut4gK1Xq786CaZzvqdS1eiU5op89606 intact-crc:1E90225B79FB74F4|rigid:U8iHQe3l4LJoZ+SJrP4LNPQtGBU false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UMW8 uniprotkb:Q7LBC6 intact:EBI-356206|uniprotkb:Q9NY71|uniprotkb:Q6IAD9|ensembl:ENSP00000215794|uniprotkb:Q53Y90 intact:EBI-2511832|ensembl:ENSP00000326563|uniprotkb:Q9BW93|uniprotkb:Q9BZ52|uniprotkb:Q9BVH6|uniprotkb:A6H8X7|uniprotkb:Q9UPS0|uniprotkb:Q9NYF4 psi-mi:ubp18_human(display_long)|uniprotkb:USP18(gene name)|psi-mi:USP18(display_short)|uniprotkb:ISG43(gene name synonym)|uniprotkb:ISG15-specific-processing protease(gene name synonym)|uniprotkb:43 kDa ISG15-specific protease(gene name synonym)|uniprotkb:Ubl thioesterase 18(gene name synonym) psi-mi:kdm3b_human(display_long)|uniprotkb:KDM3B(gene name)|psi-mi:KDM3B(display_short)|uniprotkb:C5orf7(gene name synonym)|uniprotkb:JHDM2B(gene name synonym)|uniprotkb:JMJD1B(gene name synonym)|uniprotkb:KIAA1082(gene name synonym)|uniprotkb:JmjC domain-containing histone demethylation protein 2B(gene name synonym)|uniprotkb:Jumonji domain-containing protein 1B(gene name synonym)|uniprotkb:Nuclear protein 5qNCA(gene name synonym)|uniprotkb:"[histone H3]-dimethyl-L-lysine(9) demethylase 3B"(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511849|imex:IM-12079-69 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_059110.2|ensembl:ENSG00000184979(gene)|ensembl:ENST00000215794(transcript)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019785"(ISG15-specific protease activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0060339"(negative regulation of type I interferon-mediated signaling pathway)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|mint:Q9UMW8|reactome:R-HSA-1169408|reactome:R-HSA-5689880|reactome:R-HSA-912694|dip:DIP-42723N ensembl:ENSG00000120733(gene)|ensembl:ENST00000314358(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000785"(chromatin)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0016209"(antioxidant activity)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032454"(histone H3-methyl-lysine-9 demethylase activity)|go:"GO:0033169"(histone H3-K9 demethylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051213"(dioxygenase activity)|go:"GO:0072718"(response to cisplatin)|interpro:IPR003347(Transcription factor jumonji/aspartyl beta-hydroxylase)|mint:Q7LBC6|rcsb pdb:4C8D|rcsb pdb:5R7X|rcsb pdb:5RAA|rcsb pdb:5RAC|rcsb pdb:5RAD|rcsb pdb:5RAE|rcsb pdb:5RAF|rcsb pdb:5RAG|rcsb pdb:5RAH|rcsb pdb:5RAI|rcsb pdb:5RAJ|rcsb pdb:5RAK|rcsb pdb:5RAL|rcsb pdb:5RAM|rcsb pdb:5RAN|rcsb pdb:5RAO|rcsb pdb:5RAP|rcsb pdb:5RAQ|rcsb pdb:5RAR|rcsb pdb:5RAS|rcsb pdb:5RAB|rcsb pdb:5RAU|rcsb pdb:5RAV|rcsb pdb:5RAW|rcsb pdb:5RAX|rcsb pdb:5RAY|rcsb pdb:5RAZ|rcsb pdb:5RB0|rcsb pdb:5RB1|rcsb pdb:5RB2|rcsb pdb:5RB3|rcsb pdb:5RB4|rcsb pdb:5RB5|rcsb pdb:5RB6|rcsb pdb:5RB7|rcsb pdb:6RBJ|reactome:R-HSA-3214842|refseq:NP_057688.2 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:f8gp0LV11CoEQvSGwbUVMEwRd+U9606 rogid:dtc0EOaZYDVEh5p1xgHE9uq2YVs9606 intact-crc:1E90225B79FB74F4|rigid:U8iHQe3l4LJoZ+SJrP4LNPQtGBU false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UMW8 uniprotkb:P60660 intact:EBI-356206|uniprotkb:Q9NY71|uniprotkb:Q6IAD9|ensembl:ENSP00000215794|uniprotkb:Q53Y90 intact:EBI-300817|uniprotkb:P16475|uniprotkb:P24572|uniprotkb:P24573|uniprotkb:Q12790|ensembl:ENSP00000446955|ensembl:ENSP00000448101|uniprotkb:Q6IAZ0|uniprotkb:Q6IPY5|uniprotkb:Q561V9 psi-mi:ubp18_human(display_long)|uniprotkb:USP18(gene name)|psi-mi:USP18(display_short)|uniprotkb:ISG43(gene name synonym)|uniprotkb:ISG15-specific-processing protease(gene name synonym)|uniprotkb:43 kDa ISG15-specific protease(gene name synonym)|uniprotkb:Ubl thioesterase 18(gene name synonym) psi-mi:myl6_human(display_long)|uniprotkb:MYL6(gene name)|psi-mi:MYL6(display_short)|uniprotkb:Smooth muscle and nonmuscle myosin light chain alkali 6(gene name synonym)|uniprotkb:Myosin light chain alkali 3(gene name synonym)|uniprotkb:Myosin light chain 3(gene name synonym)|uniprotkb:17 kDa myosin light chain(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511849|imex:IM-12079-69 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_059110.2|ensembl:ENSG00000184979(gene)|ensembl:ENST00000215794(transcript)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019785"(ISG15-specific protease activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0060339"(negative regulation of type I interferon-mediated signaling pathway)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|mint:Q9UMW8|reactome:R-HSA-1169408|reactome:R-HSA-5689880|reactome:R-HSA-912694|dip:DIP-42723N ensembl:ENSG00000092841(gene)|ensembl:ENST00000548293(transcript)|ensembl:ENST00000550697(transcript)|go:"GO:0000146"(microfilament motor activity)|go:"GO:0003774"(cytoskeletal motor activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005829"(cytosol)|go:"GO:0005903"(brush border)|go:"GO:0006936"(muscle contraction)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0008307"(structural constituent of muscle)|go:"GO:0016020"(membrane)|go:"GO:0016459"(myosin complex)|go:"GO:0016461"(unconventional myosin complex)|go:"GO:0030049"(muscle filament sliding)|go:"GO:0031982"(vesicle)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|mint:P60660|reactome:R-HSA-3928663|reactome:R-HSA-416572|reactome:R-HSA-445355|reactome:R-HSA-5625740|reactome:R-HSA-5625900|reactome:R-HSA-5627117|reactome:R-HSA-5627123|refseq:NP_066299.2|refseq:NP_524147.2 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:f8gp0LV11CoEQvSGwbUVMEwRd+U9606 rogid:LhE3NUqcuHlOla13C0vjnFZfzy89606 intact-crc:1E90225B79FB74F4|rigid:U8iHQe3l4LJoZ+SJrP4LNPQtGBU false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O94966 uniprotkb:Q9H2V7 intact:EBI-2511895|ensembl:ENSP00000381863|uniprotkb:Q641Q9|uniprotkb:Q86XV9|uniprotkb:Q3KQW4|uniprotkb:A6H8U2|uniprotkb:Q6NZY8|uniprotkb:A5PKX8|uniprotkb:B4DGT3|uniprotkb:E7ETS0|uniprotkb:E9PEG8|uniprotkb:B4DTZ0|uniprotkb:E7EN22 intact:EBI-1386527|uniprotkb:Q9BRN5|uniprotkb:Q6P182|uniprotkb:Q71RB5|uniprotkb:Q7L541|uniprotkb:Q86VU7|uniprotkb:Q8TCS5|uniprotkb:B5MDM9|uniprotkb:Q8N953|intact:EBI-28986516|ensembl:ENSP00000309945 psi-mi:ubp19_human(display_long)|uniprotkb:USP19(gene name)|psi-mi:USP19(display_short)|uniprotkb:KIAA0891(gene name synonym)|uniprotkb:ZMYND9(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 19(gene name synonym)|uniprotkb:Deubiquitinating enzyme 19(gene name synonym)|uniprotkb:Zinc finger MYND domain-containing protein 9(gene name synonym)|uniprotkb:Ubiquitin thioesterase 19(gene name synonym) psi-mi:spns1_human(display_long)|uniprotkb:Spinster-like protein 1(gene name synonym)|uniprotkb:HSpin1(gene name synonym)|uniprotkb:PP20300(orf name)|uniprotkb:SPNS1(gene name)|psi-mi:SPNS1(display_short)|uniprotkb:SPIN1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511876|imex:IM-12079-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000172046(gene)|ensembl:ENST00000398888(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0046872"(metal ion binding)|go:"GO:0048642"(negative regulation of skeletal muscle tissue development)|go:"GO:0050821"(protein stabilization)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0090068"(positive regulation of cell cycle process)|go:"GO:1900037"(regulation of cellular response to hypoxia)|go:"GO:1901799"(negative regulation of proteasomal protein catabolic process)|go:"GO:1904292"(regulation of ERAD pathway)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR002893(Zinc finger, MYND-type)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|mint:O94966|rcsb pdb:1WH0|rcsb pdb:4X3G|rcsb pdb:6K7W|rcsb pdb:6KHV|rcsb pdb:6KQV|reactome:R-HSA-5689880|refseq:NP_001186089.1|refseq:NP_001186090.1|refseq:NP_001186091.1|refseq:NP_006668.1|refseq:XP_005264888.1|refseq:XP_016861115.1|refseq:XP_016861122.1 refseq:NP_001135920.1|refseq:NP_001135921.1|refseq:NP_001135922.1|refseq:NP_001135923.1|refseq:NP_114427.1|ensembl:ENSP00000309945|ensembl:ENST00000323081|ensembl:ENSP00000318228|ensembl:ENST00000334536|ensembl:ENSP00000335494|ensembl:ENST00000352260|ensembl:ENSP00000306050|ensembl:ENSG00000169682(gene)|ensembl:ENST00000311008(transcript)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0006869"(lipid transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022857"(transmembrane transporter activity)|interpro:IPR011701(Major facilitator superfamily MFS-1)|interpro:IPR020846|interpro:IPR036259|interpro:IPR044770|mint:Q9H2V7 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:5U3FuLQ44MsWtu7o/3bY7seGC3M9606 rogid:ktf9VuiQy4rOhDVvg5J+wVSshec9606 intact-crc:FA7BFBBC6209D5ED|rigid:C7Rw3YMsYSriRxdgG/b9fsVZKC4 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O94966 uniprotkb:Q99497 intact:EBI-2511895|ensembl:ENSP00000381863|uniprotkb:Q641Q9|uniprotkb:Q86XV9|uniprotkb:Q3KQW4|uniprotkb:A6H8U2|uniprotkb:Q6NZY8|uniprotkb:A5PKX8|uniprotkb:B4DGT3|uniprotkb:E7ETS0|uniprotkb:E9PEG8|uniprotkb:B4DTZ0|uniprotkb:E7EN22 intact:EBI-1164361|uniprotkb:O14805|uniprotkb:Q6DR95|uniprotkb:Q7LFU2|uniprotkb:B2R4Z1|ensembl:ENSP00000340278|ensembl:ENSP00000366708|ensembl:ENSP00000366711|ensembl:ENSP00000418770|ensembl:ENSP00000465404 psi-mi:ubp19_human(display_long)|uniprotkb:USP19(gene name)|psi-mi:USP19(display_short)|uniprotkb:KIAA0891(gene name synonym)|uniprotkb:ZMYND9(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 19(gene name synonym)|uniprotkb:Deubiquitinating enzyme 19(gene name synonym)|uniprotkb:Zinc finger MYND domain-containing protein 9(gene name synonym)|uniprotkb:Ubiquitin thioesterase 19(gene name synonym) psi-mi:park7_human(display_long)|uniprotkb:PARK7(gene name)|psi-mi:PARK7(display_short)|uniprotkb:Oncogene DJ1(gene name synonym)|uniprotkb:Parkinsonism-associated deglycase(gene name synonym)|uniprotkb:Maillard deglycase(gene name synonym)|uniprotkb:Protein DJ-1(gene name synonym)|uniprotkb:Protein/nucleic acid deglycase DJ-1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511876|imex:IM-12079-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000172046(gene)|ensembl:ENST00000398888(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0046872"(metal ion binding)|go:"GO:0048642"(negative regulation of skeletal muscle tissue development)|go:"GO:0050821"(protein stabilization)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0090068"(positive regulation of cell cycle process)|go:"GO:1900037"(regulation of cellular response to hypoxia)|go:"GO:1901799"(negative regulation of proteasomal protein catabolic process)|go:"GO:1904292"(regulation of ERAD pathway)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR002893(Zinc finger, MYND-type)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|mint:O94966|rcsb pdb:1WH0|rcsb pdb:4X3G|rcsb pdb:6K7W|rcsb pdb:6KHV|rcsb pdb:6KQV|reactome:R-HSA-5689880|refseq:NP_001186089.1|refseq:NP_001186090.1|refseq:NP_001186091.1|refseq:NP_006668.1|refseq:XP_005264888.1|refseq:XP_016861115.1|refseq:XP_016861122.1 refseq:NP_001116849.1|refseq:NP_009193.2|refseq:XP_005263481.1|go:"GO:0046295"(glycolate biosynthetic process)|go:"GO:0046826"(negative regulation of protein export from nucleus)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050787"(detoxification of mercury ion)|go:"GO:0050821"(protein stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051444"(negative regulation of ubiquitin-protein transferase activity)|go:"GO:0051583"(dopamine uptake involved in synaptic transmission)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051899"(membrane depolarization)|go:"GO:0051920"(peroxiredoxin activity)|go:"GO:0060081"(membrane hyperpolarization)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0060765"(regulation of androgen receptor signaling pathway)|go:"GO:0061727"(methylglyoxal catabolic process to lactate)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070994"(detection of oxidative stress)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098793"(presynapse)|go:"GO:0106044"(guanine deglycation)|go:"GO:0106045"(guanine deglycation, methylglyoxal removal)|go:"GO:0106046"(guanine deglycation, glyoxal removal)|go:"GO:0110095"(cellular detoxification of aldehyde)|go:"GO:0140041"(cellular detoxification of methylglyoxal)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901671"(positive regulation of superoxide dismutase activity)|go:"GO:1901984"(negative regulation of protein acetylation)|go:"GO:1902177"(positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902903"(regulation of supramolecular fiber organization)|go:"GO:1902958"(positive regulation of mitochondrial electron transport, NADH to ubiquinone)|go:"GO:1903073"(negative regulation of death-inducing signaling complex assembly)|go:"GO:1903094"(negative regulation of protein K48-linked deubiquitination)|go:"GO:1903122"(negative regulation of TRAIL-activated apoptotic signaling pathway)|go:"GO:1903135"(cupric ion binding)|go:"GO:1903136"(cuprous ion binding)|go:"GO:1903168"(positive regulation of pyrroline-5-carboxylate reductase activity)|go:"GO:1903178"(positive regulation of tyrosine 3-monooxygenase activity)|go:"GO:1903181"(positive regulation of dopamine biosynthetic process)|go:"GO:1903189"(glyoxal metabolic process)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:1903200"(positive regulation of L-dopa decarboxylase activity)|go:"GO:1903202"(negative regulation of oxidative stress-induced cell death)|go:"GO:1903206"(negative regulation of hydrogen peroxide-induced cell death)|go:"GO:1903208"(negative regulation of hydrogen peroxide-induced neuron death)|go:"GO:1903377"(negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903384"(negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903427"(negative regulation of reactive oxygen species biosynthetic process)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903599"(positive regulation of autophagy of mitochondrion)|go:"GO:1905259"(negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1990381"(ubiquitin-specific protease binding)|go:"GO:1990422"("glyoxalase (glycolic acid-forming) activity")|go:"GO:2000157"(negative regulation of ubiquitin-specific protease activity)|go:"GO:2000277"(positive regulation of oxidative phosphorylation uncoupler activity)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|go:"GO:2000825"(positive regulation of androgen receptor activity)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001268"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR002818(ThiJ/PfpI)|interpro:IPR006287(DJ-1)|interpro:IPR029062|go:"GO:1903197"(positive regulation of L-dopa biosynthetic process)|rcsb pdb:3B36|rcsb pdb:3B38|rcsb pdb:3B3A|rcsb pdb:3BWE|rcsb pdb:3CY6|rcsb pdb:3CYF|rcsb pdb:3CZ9|rcsb pdb:3CZA|rcsb pdb:3EZG|mint:Q99497|rcsb pdb:1J42|rcsb pdb:1P5F|rcsb pdb:3F71|rcsb pdb:1PDV|rcsb pdb:1PDW|rcsb pdb:1PE0|rcsb pdb:1Q2U|rcsb pdb:3SF8|rcsb pdb:1SOA|rcsb pdb:1UCF|rcsb pdb:2OR3|rcsb pdb:2R1T|rcsb pdb:2R1U|rcsb pdb:2R1V|rcsb pdb:4BTE|rcsb pdb:2RK3|rcsb pdb:2RK4|rcsb pdb:2RK6|ensembl:ENSG00000116288(gene)|ensembl:ENST00000338639(transcript)|ensembl:ENST00000377488(transcript)|ensembl:ENST00000377491(transcript)|ensembl:ENST00000493678(transcript)|ensembl:ENST00000493373(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002866"(positive regulation of acute inflammatory response to antigenic stimulus)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003729"(mRNA binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0006281"(DNA repair)|rcsb pdb:4MTC|rcsb pdb:4N0M|rcsb pdb:4N12|rcsb pdb:4OGF|rcsb pdb:4OQ4|rcsb pdb:4P2G|rcsb pdb:4P34|rcsb pdb:4P35|rcsb pdb:4P36|rcsb pdb:4RKW|rcsb pdb:4RKY|rcsb pdb:4S0Z|rcsb pdb:4ZGG|rcsb pdb:5IP5|rcsb pdb:5SY6|rcsb pdb:5SY9|rcsb pdb:5SYA|rcsb pdb:6AF5|rcsb pdb:6AF7|rcsb pdb:6AF9|rcsb pdb:6AFA|rcsb pdb:6AFB|rcsb pdb:6AFC|rcsb pdb:6AFD|rcsb pdb:6AFE|rcsb pdb:6AFF|rcsb pdb:6AFG|rcsb pdb:6AFH|rcsb pdb:6AFI|rcsb pdb:6AFJ|rcsb pdb:6AFL|rcsb pdb:6E5Z|rcsb pdb:6M8Z|rcsb pdb:7C62|reactome:R-HSA-3899300|reactome:R-HSA-9613829|reactome:R-HSA-9615710|reactome:R-HSA-9646399|rcsb pdb:4MNT|go:"GO:0006517"(protein deglycosylation)|go:"GO:0006914"(autophagy)|go:"GO:0006954"(inflammatory response)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007338"(single fertilization)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008233"(peptidase activity)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0009438"(methylglyoxal metabolic process)|go:"GO:0010273"(detoxification of copper ion)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016532"(superoxide dismutase copper chaperone activity)|go:"GO:0016570"(histone modification)|go:"GO:0016605"(PML body)|go:"GO:0016684"(oxidoreductase activity, acting on peroxide as acceptor)|go:"GO:0019249"(lactate biosynthetic process)|go:"GO:0019826"(oxygen sensor activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0030424"(axon)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033182"(regulation of histone ubiquitination)|go:"GO:0033234"(negative regulation of protein sumoylation)|go:"GO:0033864"("positive regulation of NAD(P)H oxidase activity")|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035065"(regulation of histone acetylation)|go:"GO:0036470"(tyrosine 3-monooxygenase activator activity)|go:"GO:0036471"(cellular response to glyoxal)|go:"GO:0036478"(L-dopa decarboxylase activator activity)|go:"GO:0036524"(protein deglycase activity)|go:"GO:0036526"(peptidyl-cysteine deglycation)|go:"GO:0036527"(peptidyl-arginine deglycation)|go:"GO:0036528"(peptidyl-lysine deglycation)|go:"GO:0036529"(protein deglycation, glyoxal removal)|go:"GO:0036530"(protein deglycation, methylglyoxal removal)|go:"GO:0036531"(glutathione deglycation)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042743"(hydrogen peroxide metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044297"(cell body)|go:"GO:0030073"(insulin secretion)|go:"GO:0044388"(small protein activating enzyme binding)|go:"GO:0044390"(ubiquitin-like protein conjugating enzyme binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045296"(cadherin binding)|go:"GO:0045340"(mercury ion binding)|dip:DIP-35515N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:5U3FuLQ44MsWtu7o/3bY7seGC3M9606 rogid:i5ah4UPCf+4cD51ClZNggMFJMDo9606 intact-crc:FA7BFBBC6209D5ED|rigid:C7Rw3YMsYSriRxdgG/b9fsVZKC4 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O94966 uniprotkb:Q96ER3 intact:EBI-2511895|ensembl:ENSP00000381863|uniprotkb:Q641Q9|uniprotkb:Q86XV9|uniprotkb:Q3KQW4|uniprotkb:A6H8U2|uniprotkb:Q6NZY8|uniprotkb:A5PKX8|uniprotkb:B4DGT3|uniprotkb:E7ETS0|uniprotkb:E9PEG8|uniprotkb:B4DTZ0|uniprotkb:E7EN22 intact:EBI-721193|uniprotkb:A6NH05|ensembl:ENSP00000432487 psi-mi:ubp19_human(display_long)|uniprotkb:USP19(gene name)|psi-mi:USP19(display_short)|uniprotkb:KIAA0891(gene name synonym)|uniprotkb:ZMYND9(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 19(gene name synonym)|uniprotkb:Deubiquitinating enzyme 19(gene name synonym)|uniprotkb:Zinc finger MYND domain-containing protein 9(gene name synonym)|uniprotkb:Ubiquitin thioesterase 19(gene name synonym) psi-mi:saal1_human(display_long)|uniprotkb:Synoviocyte proliferation-associated in collagen-induced arthritis protein 1(gene name synonym)|uniprotkb:SAAL1(gene name)|psi-mi:SAAL1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511876|imex:IM-12079-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000172046(gene)|ensembl:ENST00000398888(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0046872"(metal ion binding)|go:"GO:0048642"(negative regulation of skeletal muscle tissue development)|go:"GO:0050821"(protein stabilization)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0090068"(positive regulation of cell cycle process)|go:"GO:1900037"(regulation of cellular response to hypoxia)|go:"GO:1901799"(negative regulation of proteasomal protein catabolic process)|go:"GO:1904292"(regulation of ERAD pathway)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR002893(Zinc finger, MYND-type)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|mint:O94966|rcsb pdb:1WH0|rcsb pdb:4X3G|rcsb pdb:6K7W|rcsb pdb:6KHV|rcsb pdb:6KQV|reactome:R-HSA-5689880|refseq:NP_001186089.1|refseq:NP_001186090.1|refseq:NP_001186091.1|refseq:NP_006668.1|refseq:XP_005264888.1|refseq:XP_016861115.1|refseq:XP_016861122.1 refseq:NP_612430.2|ensembl:ENSG00000166788(gene)|ensembl:ENST00000524803(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:1901647"(positive regulation of synoviocyte proliferation)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold) psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:5U3FuLQ44MsWtu7o/3bY7seGC3M9606 rogid:/zDVy3k3FVjctiLf1XeIeWHL9BE9606 intact-crc:FA7BFBBC6209D5ED|rigid:C7Rw3YMsYSriRxdgG/b9fsVZKC4 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O94966 uniprotkb:Q9Y5M8 intact:EBI-2511895|ensembl:ENSP00000381863|uniprotkb:Q641Q9|uniprotkb:Q86XV9|uniprotkb:Q3KQW4|uniprotkb:A6H8U2|uniprotkb:Q6NZY8|uniprotkb:A5PKX8|uniprotkb:B4DGT3|uniprotkb:E7ETS0|uniprotkb:E9PEG8|uniprotkb:B4DTZ0|uniprotkb:E7EN22 intact:EBI-355393|uniprotkb:Q8N2D8|uniprotkb:Q6P595|ensembl:ENSP00000418401|ensembl:ENSP00000503923 psi-mi:ubp19_human(display_long)|uniprotkb:USP19(gene name)|psi-mi:USP19(display_short)|uniprotkb:KIAA0891(gene name synonym)|uniprotkb:ZMYND9(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 19(gene name synonym)|uniprotkb:Deubiquitinating enzyme 19(gene name synonym)|uniprotkb:Zinc finger MYND domain-containing protein 9(gene name synonym)|uniprotkb:Ubiquitin thioesterase 19(gene name synonym) psi-mi:srprb_human(display_long)|uniprotkb:SRPRB(gene name)|psi-mi:SRPRB(display_short)|uniprotkb:PSEC0230(orf name)|uniprotkb:Protein APMCF1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511876|imex:IM-12079-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000172046(gene)|ensembl:ENST00000398888(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0046872"(metal ion binding)|go:"GO:0048642"(negative regulation of skeletal muscle tissue development)|go:"GO:0050821"(protein stabilization)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0090068"(positive regulation of cell cycle process)|go:"GO:1900037"(regulation of cellular response to hypoxia)|go:"GO:1901799"(negative regulation of proteasomal protein catabolic process)|go:"GO:1904292"(regulation of ERAD pathway)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR002893(Zinc finger, MYND-type)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|mint:O94966|rcsb pdb:1WH0|rcsb pdb:4X3G|rcsb pdb:6K7W|rcsb pdb:6KHV|rcsb pdb:6KQV|reactome:R-HSA-5689880|refseq:NP_001186089.1|refseq:NP_001186090.1|refseq:NP_001186091.1|refseq:NP_006668.1|refseq:XP_005264888.1|refseq:XP_016861115.1|refseq:XP_016861122.1 refseq:NP_067026.3|ensembl:ENSG00000144867(gene)|ensembl:ENST00000466490(transcript)|ensembl:ENST00000678299(transcript)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005785"(signal recognition particle receptor complex)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0045047"(protein targeting to ER)|interpro:IPR019009|interpro:IPR027417|mint:Q9Y5M8|rcsb pdb:7NFX|reactome:R-HSA-1799339|reactome:R-HSA-381038|dip:DIP-50218N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:5U3FuLQ44MsWtu7o/3bY7seGC3M9606 rogid:pHUdnCvOhMRYIJg//OJ+SlCard49606 intact-crc:FA7BFBBC6209D5ED|rigid:C7Rw3YMsYSriRxdgG/b9fsVZKC4 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O94966 uniprotkb:P08559 intact:EBI-2511895|ensembl:ENSP00000381863|uniprotkb:Q641Q9|uniprotkb:Q86XV9|uniprotkb:Q3KQW4|uniprotkb:A6H8U2|uniprotkb:Q6NZY8|uniprotkb:A5PKX8|uniprotkb:B4DGT3|uniprotkb:E7ETS0|uniprotkb:E9PEG8|uniprotkb:B4DTZ0|uniprotkb:E7EN22 intact:EBI-715747|uniprotkb:Q9NP12|uniprotkb:Q9UBJ8|uniprotkb:Q9UBU0|uniprotkb:Q9UNG4|uniprotkb:Q9UNG5|uniprotkb:Q5JPT8|uniprotkb:Q53H41|uniprotkb:B2R5P7|uniprotkb:B7Z3T7|uniprotkb:B7Z3X5|uniprotkb:A5YVE9|ensembl:ENSP00000394382 psi-mi:ubp19_human(display_long)|uniprotkb:USP19(gene name)|psi-mi:USP19(display_short)|uniprotkb:KIAA0891(gene name synonym)|uniprotkb:ZMYND9(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 19(gene name synonym)|uniprotkb:Deubiquitinating enzyme 19(gene name synonym)|uniprotkb:Zinc finger MYND domain-containing protein 9(gene name synonym)|uniprotkb:Ubiquitin thioesterase 19(gene name synonym) psi-mi:odpa_human(display_long)|uniprotkb:PDHE1-A type I(gene name synonym)|uniprotkb:PDHA1(gene name)|psi-mi:PDHA1(display_short)|uniprotkb:PHE1A(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511876|imex:IM-12079-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000172046(gene)|ensembl:ENST00000398888(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0046872"(metal ion binding)|go:"GO:0048642"(negative regulation of skeletal muscle tissue development)|go:"GO:0050821"(protein stabilization)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0090068"(positive regulation of cell cycle process)|go:"GO:1900037"(regulation of cellular response to hypoxia)|go:"GO:1901799"(negative regulation of proteasomal protein catabolic process)|go:"GO:1904292"(regulation of ERAD pathway)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR002893(Zinc finger, MYND-type)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|mint:O94966|rcsb pdb:1WH0|rcsb pdb:4X3G|rcsb pdb:6K7W|rcsb pdb:6KHV|rcsb pdb:6KQV|reactome:R-HSA-5689880|refseq:NP_001186089.1|refseq:NP_001186090.1|refseq:NP_001186091.1|refseq:NP_006668.1|refseq:XP_005264888.1|refseq:XP_016861115.1|refseq:XP_016861122.1 refseq:NP_001166926.1|refseq:NP_001166927.1|refseq:NP_000275.1|refseq:NP_001166925.1|ensembl:ENSG00000131828(gene)|ensembl:ENST00000422285(transcript)|go:"GO:0004739"("pyruvate dehydrogenase (acetyl-transferring) activity")|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006086"(acetyl-CoA biosynthetic process from pyruvate)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0034604"("pyruvate dehydrogenase (NAD+) activity")|go:"GO:0045254"(pyruvate dehydrogenase complex)|go:"GO:0061732"(mitochondrial acetyl-CoA biosynthetic process from pyruvate)|interpro:IPR001017(Dehydrogenase, E1 component)|interpro:IPR017597("Pyruvate dehydrogenase (acetyl-transferring) E1 component, alpha subunit, subgroup y")|interpro:IPR029061|rcsb pdb:1NI4|rcsb pdb:2OZL|rcsb pdb:3EXE|rcsb pdb:3EXF|rcsb pdb:3EXG|rcsb pdb:3EXH|rcsb pdb:3EXI|rcsb pdb:6CER|rcsb pdb:6CFO|reactome:R-HSA-204174|reactome:R-HSA-389661|reactome:R-HSA-5362517|reactome:R-HSA-70268|dip:DIP-37652N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:5U3FuLQ44MsWtu7o/3bY7seGC3M9606 rogid:p4PObFZ4cxJW6ICug+jhlgKlEYY9606 intact-crc:FA7BFBBC6209D5ED|rigid:C7Rw3YMsYSriRxdgG/b9fsVZKC4 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O94966 uniprotkb:Q15758 intact:EBI-2511895|ensembl:ENSP00000381863|uniprotkb:Q641Q9|uniprotkb:Q86XV9|uniprotkb:Q3KQW4|uniprotkb:A6H8U2|uniprotkb:Q6NZY8|uniprotkb:A5PKX8|uniprotkb:B4DGT3|uniprotkb:E7ETS0|uniprotkb:E9PEG8|uniprotkb:B4DTZ0|uniprotkb:E7EN22 intact:EBI-356576|uniprotkb:D0EYG6|uniprotkb:B4DR77|uniprotkb:B7ZB81|uniprotkb:E9PC01|uniprotkb:O95720|uniprotkb:Q96RL9|uniprotkb:Q9BWQ3|uniprotkb:Q9UNP2|uniprotkb:A8K9H5|uniprotkb:B4DWS4|ensembl:ENSP00000444408 psi-mi:ubp19_human(display_long)|uniprotkb:USP19(gene name)|psi-mi:USP19(display_short)|uniprotkb:KIAA0891(gene name synonym)|uniprotkb:ZMYND9(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 19(gene name synonym)|uniprotkb:Deubiquitinating enzyme 19(gene name synonym)|uniprotkb:Zinc finger MYND domain-containing protein 9(gene name synonym)|uniprotkb:Ubiquitin thioesterase 19(gene name synonym) psi-mi:aaat_human(display_long)|uniprotkb:ASCT2(gene name synonym)|uniprotkb:M7V1(gene name synonym)|uniprotkb:RDR(gene name synonym)|uniprotkb:RDRC(gene name synonym)|uniprotkb:SLC1A5(gene name)|psi-mi:SLC1A5(display_short)|uniprotkb:Sodium-dependent neutral amino acid transporter type 2(gene name synonym)|uniprotkb:RD114/simian type D retrovirus receptor(gene name synonym)|uniprotkb:Baboon M7 virus receptor(gene name synonym)|uniprotkb:Solute carrier family 1 member 5(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511876|imex:IM-12079-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000172046(gene)|ensembl:ENST00000398888(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0046872"(metal ion binding)|go:"GO:0048642"(negative regulation of skeletal muscle tissue development)|go:"GO:0050821"(protein stabilization)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0090068"(positive regulation of cell cycle process)|go:"GO:1900037"(regulation of cellular response to hypoxia)|go:"GO:1901799"(negative regulation of proteasomal protein catabolic process)|go:"GO:1904292"(regulation of ERAD pathway)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR002893(Zinc finger, MYND-type)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|mint:O94966|rcsb pdb:1WH0|rcsb pdb:4X3G|rcsb pdb:6K7W|rcsb pdb:6KHV|rcsb pdb:6KQV|reactome:R-HSA-5689880|refseq:NP_001186089.1|refseq:NP_001186090.1|refseq:NP_001186091.1|refseq:NP_006668.1|refseq:XP_005264888.1|refseq:XP_016861115.1|refseq:XP_016861122.1 refseq:NP_001138617.1|refseq:NP_005619.1|refseq:NP_001138616.1|go:"GO:0046872"(metal ion binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070207"(protein homotrimerization)|go:"GO:0140009"(L-aspartate import across plasma membrane)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1903803"(L-glutamine import across plasma membrane)|interpro:IPR001991("Sodium:dicarboxylate symporter")|interpro:IPR018107|interpro:IPR036458|mint:Q15758|rcsb pdb:5LLM|rcsb pdb:5LLU|rcsb pdb:5LM4|rcsb pdb:5MJU|rcsb pdb:6GCT|rcsb pdb:6MP6|rcsb pdb:6MPB|rcsb pdb:6RVX|rcsb pdb:6RVY|reactome:R-HSA-352230|reactome:R-HSA-9013149|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013409|reactome:R-HSA-9013423|go:"GO:0042470"(melanosome)|ensembl:ENSG00000105281(gene)|ensembl:ENST00000542575(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006865"(amino acid transport)|go:"GO:0006868"(glutamine transport)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0010585"(glutamine secretion)|go:"GO:0015171"(amino acid transmembrane transporter activity)|go:"GO:0015175"(neutral amino acid transmembrane transporter activity)|go:"GO:0015183"(L-aspartate transmembrane transporter activity)|go:"GO:0015186"(L-glutamine transmembrane transporter activity)|go:"GO:0015194"(L-serine transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015804"(neutral amino acid transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0038023"(signaling receptor activity) psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:5U3FuLQ44MsWtu7o/3bY7seGC3M9606 rogid:nkh427WmAX5SLFm24BvEpyoyAmw9606 intact-crc:FA7BFBBC6209D5ED|rigid:C7Rw3YMsYSriRxdgG/b9fsVZKC4 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O94966 uniprotkb:Q96N67 intact:EBI-2511895|ensembl:ENSP00000381863|uniprotkb:Q641Q9|uniprotkb:Q86XV9|uniprotkb:Q3KQW4|uniprotkb:A6H8U2|uniprotkb:Q6NZY8|uniprotkb:A5PKX8|uniprotkb:B4DGT3|uniprotkb:E7ETS0|uniprotkb:E9PEG8|uniprotkb:B4DTZ0|uniprotkb:E7EN22 intact:EBI-2433703|uniprotkb:Q00M63|uniprotkb:Q2PPY7|uniprotkb:Q45RE8|uniprotkb:Q45RE9|uniprotkb:Q5T1B9|uniprotkb:Q5T1C0|uniprotkb:Q6ZV32|uniprotkb:Q8TB82|uniprotkb:Q96NG6|uniprotkb:Q9C092|intact:EBI-7303260|intact:MINT-1683616|uniprotkb:Q96NI0|intact:EBI-28980506|ensembl:ENSP00000489124 psi-mi:ubp19_human(display_long)|uniprotkb:USP19(gene name)|psi-mi:USP19(display_short)|uniprotkb:KIAA0891(gene name synonym)|uniprotkb:ZMYND9(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 19(gene name synonym)|uniprotkb:Deubiquitinating enzyme 19(gene name synonym)|uniprotkb:Zinc finger MYND domain-containing protein 9(gene name synonym)|uniprotkb:Ubiquitin thioesterase 19(gene name synonym) psi-mi:dock7_human(display_long)|uniprotkb:DOCK7(gene name)|psi-mi:DOCK7(display_short)|uniprotkb:KIAA1771(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511876|imex:IM-12079-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000172046(gene)|ensembl:ENST00000398888(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0046872"(metal ion binding)|go:"GO:0048642"(negative regulation of skeletal muscle tissue development)|go:"GO:0050821"(protein stabilization)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0090068"(positive regulation of cell cycle process)|go:"GO:1900037"(regulation of cellular response to hypoxia)|go:"GO:1901799"(negative regulation of proteasomal protein catabolic process)|go:"GO:1904292"(regulation of ERAD pathway)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR002893(Zinc finger, MYND-type)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|mint:O94966|rcsb pdb:1WH0|rcsb pdb:4X3G|rcsb pdb:6K7W|rcsb pdb:6KHV|rcsb pdb:6KQV|reactome:R-HSA-5689880|refseq:NP_001186089.1|refseq:NP_001186090.1|refseq:NP_001186091.1|refseq:NP_006668.1|refseq:XP_005264888.1|refseq:XP_016861115.1|refseq:XP_016861122.1 refseq:XP_011540628.1|refseq:NP_001258931.1|refseq:NP_212132.2|ensembl:ENST00000251157|ensembl:ENSP00000251157|ensembl:ENST00000340370|ensembl:ENSP00000340742|ensembl:ENST00000404627|ensembl:ENSP00000384446|ensembl:ENST00000454575|ensembl:ENSP00000413583|ensembl:ENST00000634264|ensembl:ENSP00000489284|ensembl:ENST00000635123|ensembl:ENSP00000489499|ensembl:ENSP00000489124|refseq:NP_001258928.1|refseq:NP_001258929.1|refseq:NP_001258930.1|refseq:NP_001317543.1|ensembl:ENSG00000116641(gene)|ensembl:ENST00000635253(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005925"(focal adhesion)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0007409"(axonogenesis)|go:"GO:0022027"(interkinetic nuclear migration)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0031175"(neuron projection development)|go:"GO:0031267"(small GTPase binding)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0043005"(neuron projection)|go:"GO:0045178"(basal part of cell)|go:"GO:0045200"(establishment of neuroblast polarity)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|interpro:IPR010703(Dedicator of cytokinesis)|interpro:IPR021816|interpro:IPR026791|interpro:IPR027007|interpro:IPR027357|interpro:IPR035892|interpro:IPR037808|interpro:IPR043161|interpro:IPR043162|mint:Q96N67|rcsb pdb:6AJ4|rcsb pdb:6AJL|reactome:R-HSA-8875555|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-983231 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:5U3FuLQ44MsWtu7o/3bY7seGC3M9606 rogid:PHjIS0j8JJ6Il3knhzjCzMNkxKk9606 intact-crc:FA7BFBBC6209D5ED|rigid:C7Rw3YMsYSriRxdgG/b9fsVZKC4 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O94966 uniprotkb:P06493 intact:EBI-2511895|ensembl:ENSP00000381863|uniprotkb:Q641Q9|uniprotkb:Q86XV9|uniprotkb:Q3KQW4|uniprotkb:A6H8U2|uniprotkb:Q6NZY8|uniprotkb:A5PKX8|uniprotkb:B4DGT3|uniprotkb:E7ETS0|uniprotkb:E9PEG8|uniprotkb:B4DTZ0|uniprotkb:E7EN22 intact:EBI-444308|ensembl:ENSP00000378699|uniprotkb:O60764|uniprotkb:C9J497|uniprotkb:A8K7C4 psi-mi:ubp19_human(display_long)|uniprotkb:USP19(gene name)|psi-mi:USP19(display_short)|uniprotkb:KIAA0891(gene name synonym)|uniprotkb:ZMYND9(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 19(gene name synonym)|uniprotkb:Deubiquitinating enzyme 19(gene name synonym)|uniprotkb:Zinc finger MYND domain-containing protein 9(gene name synonym)|uniprotkb:Ubiquitin thioesterase 19(gene name synonym) psi-mi:cdk1_human(display_long)|uniprotkb:p34 protein kinase(gene name synonym)|uniprotkb:Cell division protein kinase 1(gene name synonym)|uniprotkb:CDK1(gene name)|psi-mi:CDK1(display_short)|uniprotkb:CDC2(gene name synonym)|uniprotkb:Cell division control protein 2 homolog(gene name synonym)|uniprotkb:CDC28A(gene name synonym)|uniprotkb:CDKN1(gene name synonym)|uniprotkb:P34CDC2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511876|imex:IM-12079-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000172046(gene)|ensembl:ENST00000398888(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0046872"(metal ion binding)|go:"GO:0048642"(negative regulation of skeletal muscle tissue development)|go:"GO:0050821"(protein stabilization)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0090068"(positive regulation of cell cycle process)|go:"GO:1900037"(regulation of cellular response to hypoxia)|go:"GO:1901799"(negative regulation of proteasomal protein catabolic process)|go:"GO:1904292"(regulation of ERAD pathway)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR002893(Zinc finger, MYND-type)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|mint:O94966|rcsb pdb:1WH0|rcsb pdb:4X3G|rcsb pdb:6K7W|rcsb pdb:6KHV|rcsb pdb:6KQV|reactome:R-HSA-5689880|refseq:NP_001186089.1|refseq:NP_001186090.1|refseq:NP_001186091.1|refseq:NP_006668.1|refseq:XP_005264888.1|refseq:XP_016861115.1|refseq:XP_016861122.1 go:"GO:0006281"(DNA repair)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007344"(pronuclear fusion)|go:"GO:0007569"(cell aging)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0014038"(regulation of Schwann cell differentiation)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014075"(response to amine)|go:"GO:0014823"(response to activity)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030261"(chromosome condensation)|go:"GO:0030332"(cyclin binding)|go:"GO:0030496"(midbody)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0034501"(protein localization to kinetochore)|go:"GO:0035173"(histone kinase activity)|go:"GO:0006260"(DNA replication)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0046688"(response to copper ion)|go:"GO:0048511"(rhythmic process)|go:"GO:0048678"(response to axon injury)|go:"GO:0051301"(cell division)|go:"GO:0055015"(ventricular cardiac muscle cell development)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0042493"|go:"GO:0072686"(mitotic spindle)|go:"GO:0090166"(Golgi disassembly)|go:"GO:0097125"(cyclin B1-CDK1 complex)|go:"GO:0097472"(cyclin-dependent protein kinase activity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1905448"(positive regulation of mitochondrial ATP synthesis coupled electron transport)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P06493|rcsb pdb:1LC9|rcsb pdb:4Y72|rcsb pdb:4YC3|rcsb pdb:4YC6|rcsb pdb:5HQ0|rcsb pdb:5LQF|rcsb pdb:6GU2|rcsb pdb:6GU3|rcsb pdb:6GU4|rcsb pdb:6GU6|go:"GO:0042752"(regulation of circadian rhythm)|rcsb pdb:6GU7|rcsb pdb:6TWN|reactome:R-HSA-110056|reactome:R-HSA-113507|reactome:R-HSA-1362300|reactome:R-HSA-162658|reactome:R-HSA-170145|reactome:R-HSA-174048|reactome:R-HSA-174184|reactome:R-HSA-176408|reactome:R-HSA-176412|reactome:R-HSA-176417|reactome:R-HSA-2299718|reactome:R-HSA-2465910|reactome:R-HSA-2500257|reactome:R-HSA-2514853|reactome:R-HSA-2565942|reactome:R-HSA-2980767|reactome:R-HSA-2995383|reactome:R-HSA-3301854|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-4419969|reactome:R-HSA-5620912|reactome:R-HSA-5687128|reactome:R-HSA-5689896|reactome:R-HSA-6804114|reactome:R-HSA-6804757|reactome:R-HSA-68875|reactome:R-HSA-69205|reactome:R-HSA-69273|reactome:R-HSA-69478|reactome:R-HSA-75035|reactome:R-HSA-8852276|reactome:R-HSA-8854518|reactome:R-HSA-8878166|ensembl:ENSG00000170312(gene)|ensembl:ENST00000395284(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001618"(virus receptor activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005876"(spindle microtubule)|refseq:NP_001777.1|refseq:NP_203698.1|refseq:XP_005270360.1|refseq:NP_001307847.1|dip:DIP-35N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:5U3FuLQ44MsWtu7o/3bY7seGC3M9606 rogid:8geyXVp0Rpm8sG8I76/XgWsZ4JA9606 intact-crc:FA7BFBBC6209D5ED|rigid:C7Rw3YMsYSriRxdgG/b9fsVZKC4 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O94966 uniprotkb:Q9H9S3 intact:EBI-2511895|ensembl:ENSP00000381863|uniprotkb:Q641Q9|uniprotkb:Q86XV9|uniprotkb:Q3KQW4|uniprotkb:A6H8U2|uniprotkb:Q6NZY8|uniprotkb:A5PKX8|uniprotkb:B4DGT3|uniprotkb:E7ETS0|uniprotkb:E9PEG8|uniprotkb:B4DTZ0|uniprotkb:E7EN22 intact:EBI-1172006|uniprotkb:B4DX72|uniprotkb:F8W773|uniprotkb:A8K8D0|ensembl:ENSP00000298428 psi-mi:ubp19_human(display_long)|uniprotkb:USP19(gene name)|psi-mi:USP19(display_short)|uniprotkb:KIAA0891(gene name synonym)|uniprotkb:ZMYND9(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 19(gene name synonym)|uniprotkb:Deubiquitinating enzyme 19(gene name synonym)|uniprotkb:Zinc finger MYND domain-containing protein 9(gene name synonym)|uniprotkb:Ubiquitin thioesterase 19(gene name synonym) psi-mi:s61a2_human(display_long)|uniprotkb:SEC61A2(gene name)|psi-mi:SEC61A2(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511876|imex:IM-12079-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000172046(gene)|ensembl:ENST00000398888(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0046872"(metal ion binding)|go:"GO:0048642"(negative regulation of skeletal muscle tissue development)|go:"GO:0050821"(protein stabilization)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0090068"(positive regulation of cell cycle process)|go:"GO:1900037"(regulation of cellular response to hypoxia)|go:"GO:1901799"(negative regulation of proteasomal protein catabolic process)|go:"GO:1904292"(regulation of ERAD pathway)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR002893(Zinc finger, MYND-type)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|mint:O94966|rcsb pdb:1WH0|rcsb pdb:4X3G|rcsb pdb:6K7W|rcsb pdb:6KHV|rcsb pdb:6KQV|reactome:R-HSA-5689880|refseq:NP_001186089.1|refseq:NP_001186090.1|refseq:NP_001186091.1|refseq:NP_006668.1|refseq:XP_005264888.1|refseq:XP_016861115.1|refseq:XP_016861122.1 refseq:NP_001136099.1|refseq:NP_060614.2|ensembl:ENSG00000065665(gene)|ensembl:ENST00000298428(transcript)|go:"GO:0005048"(signal sequence binding)|go:"GO:0006616"(SRP-dependent cotranslational protein targeting to membrane, translocation)|go:"GO:0008320"(protein transmembrane transporter activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031204"(posttranslational protein targeting to membrane, translocation)|go:"GO:0043022"(ribosome binding)|interpro:IPR002208(SecY protein)|interpro:IPR019561|interpro:IPR023201|interpro:IPR030659|reactome:R-HSA-1236974|reactome:R-HSA-1799339|go:"GO:0005784"(Sec61 translocon complex)|refseq:NP_001136100.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:5U3FuLQ44MsWtu7o/3bY7seGC3M9606 rogid:hZDOdPuauwpCSX5aDYdhLPqQsd89606 intact-crc:FA7BFBBC6209D5ED|rigid:C7Rw3YMsYSriRxdgG/b9fsVZKC4 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O94966 uniprotkb:P55060 intact:EBI-2511895|ensembl:ENSP00000381863|uniprotkb:Q641Q9|uniprotkb:Q86XV9|uniprotkb:Q3KQW4|uniprotkb:A6H8U2|uniprotkb:Q6NZY8|uniprotkb:A5PKX8|uniprotkb:B4DGT3|uniprotkb:E7ETS0|uniprotkb:E9PEG8|uniprotkb:B4DTZ0|uniprotkb:E7EN22 intact:EBI-286709|uniprotkb:O75432|uniprotkb:Q32M40|uniprotkb:Q9H5B7|uniprotkb:Q9NTS0|uniprotkb:Q9UP98|uniprotkb:Q9UP99|uniprotkb:Q9UPA0|uniprotkb:B2R5T4|uniprotkb:E1P5Y0|uniprotkb:A3RLL6|uniprotkb:F8W904|ensembl:ENSP00000262982 psi-mi:ubp19_human(display_long)|uniprotkb:USP19(gene name)|psi-mi:USP19(display_short)|uniprotkb:KIAA0891(gene name synonym)|uniprotkb:ZMYND9(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 19(gene name synonym)|uniprotkb:Deubiquitinating enzyme 19(gene name synonym)|uniprotkb:Zinc finger MYND domain-containing protein 9(gene name synonym)|uniprotkb:Ubiquitin thioesterase 19(gene name synonym) psi-mi:xpo2_human(display_long)|uniprotkb:Importin-alpha re-exporter(gene name synonym)|uniprotkb:Chromosome segregation 1-like protein(gene name synonym)|uniprotkb:Cellular apoptosis susceptibility protein(gene name synonym)|uniprotkb:CSE1L(gene name)|psi-mi:CSE1L(display_short)|uniprotkb:CAS(gene name synonym)|uniprotkb:XPO2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511876|imex:IM-12079-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000172046(gene)|ensembl:ENST00000398888(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0046872"(metal ion binding)|go:"GO:0048642"(negative regulation of skeletal muscle tissue development)|go:"GO:0050821"(protein stabilization)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0090068"(positive regulation of cell cycle process)|go:"GO:1900037"(regulation of cellular response to hypoxia)|go:"GO:1901799"(negative regulation of proteasomal protein catabolic process)|go:"GO:1904292"(regulation of ERAD pathway)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR002893(Zinc finger, MYND-type)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|mint:O94966|rcsb pdb:1WH0|rcsb pdb:4X3G|rcsb pdb:6K7W|rcsb pdb:6KHV|rcsb pdb:6KQV|reactome:R-HSA-5689880|refseq:NP_001186089.1|refseq:NP_001186090.1|refseq:NP_001186091.1|refseq:NP_006668.1|refseq:XP_005264888.1|refseq:XP_016861115.1|refseq:XP_016861122.1 refseq:XP_011526901.1|refseq:NP_001307.2|refseq:NP_001243064.1|dip:DIP-32573N|ensembl:ENSG00000124207(gene)|ensembl:ENST00000262982(transcript)|go:"GO:0005049"(nuclear export signal receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0016020"(membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001494(Importin-beta, N-terminal)|interpro:IPR005043(CAS/CSE, C-terminal)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013713(Exportin, Cse1-like)|interpro:IPR016024(Armadillo-type fold)|mint:P55060 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:5U3FuLQ44MsWtu7o/3bY7seGC3M9606 rogid:5MlTHLE2eN8Cj5K4xhSt6lCheVs9606 intact-crc:FA7BFBBC6209D5ED|rigid:C7Rw3YMsYSriRxdgG/b9fsVZKC4 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O94966 uniprotkb:Q13555 intact:EBI-2511895|ensembl:ENSP00000381863|uniprotkb:Q641Q9|uniprotkb:Q86XV9|uniprotkb:Q3KQW4|uniprotkb:A6H8U2|uniprotkb:Q6NZY8|uniprotkb:A5PKX8|uniprotkb:B4DGT3|uniprotkb:E7ETS0|uniprotkb:E9PEG8|uniprotkb:B4DTZ0|uniprotkb:E7EN22 intact:EBI-1383465|uniprotkb:O00561|uniprotkb:Q5SWX4|uniprotkb:Q8NIA4|uniprotkb:O15378|uniprotkb:Q13556|uniprotkb:Q5SQZ3|uniprotkb:Q5SQZ4|uniprotkb:Q8N4I3|uniprotkb:Q13279|uniprotkb:Q13282|uniprotkb:Q7KYX5|uniprotkb:A0A0A0MS52|uniprotkb:A0A0A0MT11 psi-mi:ubp19_human(display_long)|uniprotkb:USP19(gene name)|psi-mi:USP19(display_short)|uniprotkb:KIAA0891(gene name synonym)|uniprotkb:ZMYND9(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 19(gene name synonym)|uniprotkb:Deubiquitinating enzyme 19(gene name synonym)|uniprotkb:Zinc finger MYND domain-containing protein 9(gene name synonym)|uniprotkb:Ubiquitin thioesterase 19(gene name synonym) psi-mi:kcc2g_human(display_long)|uniprotkb:CAMK(gene name synonym)|uniprotkb:CAMK-II(gene name synonym)|uniprotkb:CAMK2G(gene name)|psi-mi:CAMK2G(display_short)|uniprotkb:CAMKG(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511876|imex:IM-12079-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000172046(gene)|ensembl:ENST00000398888(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0046872"(metal ion binding)|go:"GO:0048642"(negative regulation of skeletal muscle tissue development)|go:"GO:0050821"(protein stabilization)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0090068"(positive regulation of cell cycle process)|go:"GO:1900037"(regulation of cellular response to hypoxia)|go:"GO:1901799"(negative regulation of proteasomal protein catabolic process)|go:"GO:1904292"(regulation of ERAD pathway)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR002893(Zinc finger, MYND-type)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|mint:O94966|rcsb pdb:1WH0|rcsb pdb:4X3G|rcsb pdb:6K7W|rcsb pdb:6KHV|rcsb pdb:6KQV|reactome:R-HSA-5689880|refseq:NP_001186089.1|refseq:NP_001186090.1|refseq:NP_001186091.1|refseq:NP_006668.1|refseq:XP_005264888.1|refseq:XP_016861115.1|refseq:XP_016861122.1 refseq:NP_001213.2|refseq:NP_751909.1|refseq:NP_751913.1|refseq:XP_005270260.1|refseq:NP_001307827.1|refseq:NP_001191421.1|dip:DIP-51315N|mint:Q13555|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-877300|reactome:R-HSA-9022692|reactome:R-HSA-936837|reactome:R-HSA-9609736|reactome:R-HSA-9617324|reactome:R-HSA-9620244|reactome:R-HSA-9649948|reactome:R-HSA-9656223|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0004723"(calcium-dependent protein serine/threonine phosphatase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005954"(calcium- and calmodulin-dependent protein kinase complex)|go:"GO:0007399"(nervous system development)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0014733"(regulation of skeletal muscle adaptation)|go:"GO:0016020"(membrane)|go:"GO:0030073"(insulin secretion)|go:"GO:0030154"(cell differentiation)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013543(Calcium/calmodulin dependent protein kinase II, association-domain)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR032710|rcsb pdb:2UX0|rcsb pdb:2V7O|reactome:R-HSA-111932|reactome:R-HSA-3371571|reactome:R-HSA-399719|reactome:R-HSA-438066|reactome:R-HSA-442729|reactome:R-HSA-442982|reactome:R-HSA-5576892|reactome:R-HSA-5578775|reactome:R-HSA-5673000|reactome:R-HSA-5673001|reactome:R-HSA-6802946 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:5U3FuLQ44MsWtu7o/3bY7seGC3M9606 rogid:qtCEps5UkV7tprB2QmjCDK5YyIo9606 intact-crc:FA7BFBBC6209D5ED|rigid:C7Rw3YMsYSriRxdgG/b9fsVZKC4 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O94966 uniprotkb:Q09019 intact:EBI-2511895|ensembl:ENSP00000381863|uniprotkb:Q641Q9|uniprotkb:Q86XV9|uniprotkb:Q3KQW4|uniprotkb:A6H8U2|uniprotkb:Q6NZY8|uniprotkb:A5PKX8|uniprotkb:B4DGT3|uniprotkb:E7ETS0|uniprotkb:E9PEG8|uniprotkb:B4DTZ0|uniprotkb:E7EN22 intact:EBI-724564|ensembl:ENSP00000270223 psi-mi:ubp19_human(display_long)|uniprotkb:USP19(gene name)|psi-mi:USP19(display_short)|uniprotkb:KIAA0891(gene name synonym)|uniprotkb:ZMYND9(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 19(gene name synonym)|uniprotkb:Deubiquitinating enzyme 19(gene name synonym)|uniprotkb:Zinc finger MYND domain-containing protein 9(gene name synonym)|uniprotkb:Ubiquitin thioesterase 19(gene name synonym) psi-mi:dmwd_human(display_long)|uniprotkb:Dystrophia myotonica-containing WD repeat motif protein(gene name synonym)|uniprotkb:Protein DMR-N9(gene name synonym)|uniprotkb:Protein 59(gene name synonym)|uniprotkb:DMWD(gene name)|psi-mi:DMWD(display_short)|uniprotkb:DM9(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511876|imex:IM-12079-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000172046(gene)|ensembl:ENST00000398888(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0046872"(metal ion binding)|go:"GO:0048642"(negative regulation of skeletal muscle tissue development)|go:"GO:0050821"(protein stabilization)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0090068"(positive regulation of cell cycle process)|go:"GO:1900037"(regulation of cellular response to hypoxia)|go:"GO:1901799"(negative regulation of proteasomal protein catabolic process)|go:"GO:1904292"(regulation of ERAD pathway)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR002893(Zinc finger, MYND-type)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|mint:O94966|rcsb pdb:1WH0|rcsb pdb:4X3G|rcsb pdb:6K7W|rcsb pdb:6KHV|rcsb pdb:6KQV|reactome:R-HSA-5689880|refseq:NP_001186089.1|refseq:NP_001186090.1|refseq:NP_001186091.1|refseq:NP_006668.1|refseq:XP_005264888.1|refseq:XP_016861115.1|refseq:XP_016861122.1 refseq:NP_004934.1|ensembl:ENSG00000185800(gene)|ensembl:ENST00000270223(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0030425"(dendrite)|go:"GO:0043204"(perikaryon)|interpro:IPR001680(WD40 repeat)|interpro:IPR036322|mint:Q09019 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:5U3FuLQ44MsWtu7o/3bY7seGC3M9606 rogid:76SLwlB1ohLxjwUwpPOR6gT4DP89606 intact-crc:FA7BFBBC6209D5ED|rigid:C7Rw3YMsYSriRxdgG/b9fsVZKC4 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O94966 uniprotkb:P42704 intact:EBI-2511895|ensembl:ENSP00000381863|uniprotkb:Q641Q9|uniprotkb:Q86XV9|uniprotkb:Q3KQW4|uniprotkb:A6H8U2|uniprotkb:Q6NZY8|uniprotkb:A5PKX8|uniprotkb:B4DGT3|uniprotkb:E7ETS0|uniprotkb:E9PEG8|uniprotkb:B4DTZ0|uniprotkb:E7EN22 intact:EBI-1050853|uniprotkb:A0PJE3|uniprotkb:A8K1V1|uniprotkb:Q53PC0|uniprotkb:Q53QN7|uniprotkb:Q96D84|uniprotkb:Q6ZUD8|uniprotkb:Q7Z7A6|ensembl:ENSP00000260665 psi-mi:ubp19_human(display_long)|uniprotkb:USP19(gene name)|psi-mi:USP19(display_short)|uniprotkb:KIAA0891(gene name synonym)|uniprotkb:ZMYND9(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 19(gene name synonym)|uniprotkb:Deubiquitinating enzyme 19(gene name synonym)|uniprotkb:Zinc finger MYND domain-containing protein 9(gene name synonym)|uniprotkb:Ubiquitin thioesterase 19(gene name synonym) psi-mi:lpprc_human(display_long)|uniprotkb:130 kDa leucine-rich protein(gene name synonym)|uniprotkb:GP130(gene name synonym)|uniprotkb:LRPPRC(gene name)|psi-mi:LRPPRC(display_short)|uniprotkb:LRP130(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511876|imex:IM-12079-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000172046(gene)|ensembl:ENST00000398888(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0046872"(metal ion binding)|go:"GO:0048642"(negative regulation of skeletal muscle tissue development)|go:"GO:0050821"(protein stabilization)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0090068"(positive regulation of cell cycle process)|go:"GO:1900037"(regulation of cellular response to hypoxia)|go:"GO:1901799"(negative regulation of proteasomal protein catabolic process)|go:"GO:1904292"(regulation of ERAD pathway)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR002893(Zinc finger, MYND-type)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|mint:O94966|rcsb pdb:1WH0|rcsb pdb:4X3G|rcsb pdb:6K7W|rcsb pdb:6KHV|rcsb pdb:6KQV|reactome:R-HSA-5689880|refseq:NP_001186089.1|refseq:NP_001186090.1|refseq:NP_001186091.1|refseq:NP_006668.1|refseq:XP_005264888.1|refseq:XP_016861115.1|refseq:XP_016861122.1 refseq:NP_573566.2|ensembl:ENSG00000138095(gene)|ensembl:ENST00000260665(transcript)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0000961"(negative regulation of mitochondrial RNA catabolic process)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005640"(nuclear outer membrane)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005874"(microtubule)|go:"GO:0008017"(microtubule binding)|go:"GO:0016020"(membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0047497"(mitochondrion transport along microtubule)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0051028"(mRNA transport)|go:"GO:0070129"(regulation of mitochondrial translation)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR002885(Pentatricopeptide repeat)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR033443|interpro:IPR033490|mint:P42704|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564|dip:DIP-27543N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:5U3FuLQ44MsWtu7o/3bY7seGC3M9606 rogid:U0ERiW4agkBDQ7iWXWgRQxhozkg9606 intact-crc:FA7BFBBC6209D5ED|rigid:C7Rw3YMsYSriRxdgG/b9fsVZKC4 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O94966 uniprotkb:Q92616 intact:EBI-2511895|ensembl:ENSP00000381863|uniprotkb:Q641Q9|uniprotkb:Q86XV9|uniprotkb:Q3KQW4|uniprotkb:A6H8U2|uniprotkb:Q6NZY8|uniprotkb:A5PKX8|uniprotkb:B4DGT3|uniprotkb:E7ETS0|uniprotkb:E9PEG8|uniprotkb:B4DTZ0|uniprotkb:E7EN22 intact:EBI-356221|ensembl:ENSP00000300648|uniprotkb:O95001|uniprotkb:O95651|uniprotkb:Q6P2S3|uniprotkb:Q86X65|uniprotkb:Q8N5I5|uniprotkb:Q8WU80|uniprotkb:Q99736|uniprotkb:Q9UE60|uniprotkb:A8KAY1|intact:EBI-1058692 psi-mi:ubp19_human(display_long)|uniprotkb:USP19(gene name)|psi-mi:USP19(display_short)|uniprotkb:KIAA0891(gene name synonym)|uniprotkb:ZMYND9(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 19(gene name synonym)|uniprotkb:Deubiquitinating enzyme 19(gene name synonym)|uniprotkb:Zinc finger MYND domain-containing protein 9(gene name synonym)|uniprotkb:Ubiquitin thioesterase 19(gene name synonym) psi-mi:gcn1_human(display_long)|uniprotkb:GCN1(gene name)|psi-mi:GCN1(display_short)|uniprotkb:GCN1 eIF-2-alpha kinase activator homolog(gene name synonym)|uniprotkb:GCN1-like protein 1(gene name synonym)|uniprotkb:GCN1L1(gene name synonym)|uniprotkb:General control of amino-acid synthesis 1-like protein 1(gene name synonym)|uniprotkb:KIAA0219(gene name synonym)|uniprotkb:Translational activator GCN1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511876|imex:IM-12079-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000172046(gene)|ensembl:ENST00000398888(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0046872"(metal ion binding)|go:"GO:0048642"(negative regulation of skeletal muscle tissue development)|go:"GO:0050821"(protein stabilization)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0090068"(positive regulation of cell cycle process)|go:"GO:1900037"(regulation of cellular response to hypoxia)|go:"GO:1901799"(negative regulation of proteasomal protein catabolic process)|go:"GO:1904292"(regulation of ERAD pathway)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR002893(Zinc finger, MYND-type)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|mint:O94966|rcsb pdb:1WH0|rcsb pdb:4X3G|rcsb pdb:6K7W|rcsb pdb:6KHV|rcsb pdb:6KQV|reactome:R-HSA-5689880|refseq:NP_001186089.1|refseq:NP_001186090.1|refseq:NP_001186091.1|refseq:NP_006668.1|refseq:XP_005264888.1|refseq:XP_016861115.1|refseq:XP_016861122.1 ensembl:ENSG00000089154(gene)|ensembl:ENST00000300648(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0008135"(translation factor activity, RNA binding)|go:"GO:0016020"(membrane)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0036003"(positive regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0043022"(ribosome binding)|go:"GO:0045296"(cadherin binding)|go:"GO:1990253"(cellular response to leucine starvation)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR021133|interpro:IPR033173|interpro:IPR034085|mint:Q92616|reactome:R-HSA-9633012|go:"GO:0005844"(polysome)|refseq:NP_006827.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:5U3FuLQ44MsWtu7o/3bY7seGC3M9606 rogid:NtSEW6xjvCkUyb40cnk0JdL5PcA9606 intact-crc:FA7BFBBC6209D5ED|rigid:C7Rw3YMsYSriRxdgG/b9fsVZKC4 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O94966 intact:EBI-2511910 intact:EBI-2511895|ensembl:ENSP00000381863|uniprotkb:Q641Q9|uniprotkb:Q86XV9|uniprotkb:Q3KQW4|uniprotkb:A6H8U2|uniprotkb:Q6NZY8|uniprotkb:A5PKX8|uniprotkb:B4DGT3|uniprotkb:E7ETS0|uniprotkb:E9PEG8|uniprotkb:B4DTZ0|uniprotkb:E7EN22 - psi-mi:ubp19_human(display_long)|uniprotkb:USP19(gene name)|psi-mi:USP19(display_short)|uniprotkb:KIAA0891(gene name synonym)|uniprotkb:ZMYND9(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 19(gene name synonym)|uniprotkb:Deubiquitinating enzyme 19(gene name synonym)|uniprotkb:Zinc finger MYND domain-containing protein 9(gene name synonym)|uniprotkb:Ubiquitin thioesterase 19(gene name synonym) psi-mi:q5tcd1_human(display_short)|psi-mi:EBI-2511910(display_long)|uniprotkb:IARS1(gene name)|psi-mi:IARS1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511876|imex:IM-12079-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000172046(gene)|ensembl:ENST00000398888(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0046872"(metal ion binding)|go:"GO:0048642"(negative regulation of skeletal muscle tissue development)|go:"GO:0050821"(protein stabilization)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0090068"(positive regulation of cell cycle process)|go:"GO:1900037"(regulation of cellular response to hypoxia)|go:"GO:1901799"(negative regulation of proteasomal protein catabolic process)|go:"GO:1904292"(regulation of ERAD pathway)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR002893(Zinc finger, MYND-type)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|mint:O94966|rcsb pdb:1WH0|rcsb pdb:4X3G|rcsb pdb:6K7W|rcsb pdb:6KHV|rcsb pdb:6KQV|reactome:R-HSA-5689880|refseq:NP_001186089.1|refseq:NP_001186090.1|refseq:NP_001186091.1|refseq:NP_006668.1|refseq:XP_005264888.1|refseq:XP_016861115.1|refseq:XP_016861122.1 uniprotkb:Q5TCD1(uniprot-removed-ac) psi-mi:"MI:0469"(intact) - no-uniprot-update:|caution:The sequence has been withdrawn from uniprot. figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:5U3FuLQ44MsWtu7o/3bY7seGC3M9606 rogid:g4tuIvaQsu3hGUtB1vTdHqyeufw9606 intact-crc:FA7BFBBC6209D5ED|rigid:C7Rw3YMsYSriRxdgG/b9fsVZKC4 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O94966 uniprotkb:Q8NBU5 intact:EBI-2511895|ensembl:ENSP00000381863|uniprotkb:Q641Q9|uniprotkb:Q86XV9|uniprotkb:Q3KQW4|uniprotkb:A6H8U2|uniprotkb:Q6NZY8|uniprotkb:A5PKX8|uniprotkb:B4DGT3|uniprotkb:E7ETS0|uniprotkb:E9PEG8|uniprotkb:B4DTZ0|uniprotkb:E7EN22 intact:EBI-2511886|ensembl:ENSP00000339016|ensembl:ENSP00000339017|ensembl:ENSP00000489353|ensembl:ENSP00000489455|ensembl:ENSP00000506333|uniprotkb:Q6P4B9|uniprotkb:Q969Y3|uniprotkb:Q8WYR9|uniprotkb:Q8N3G1|uniprotkb:Q6DKG1|uniprotkb:D3DR26 psi-mi:ubp19_human(display_long)|uniprotkb:USP19(gene name)|psi-mi:USP19(display_short)|uniprotkb:KIAA0891(gene name synonym)|uniprotkb:ZMYND9(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 19(gene name synonym)|uniprotkb:Deubiquitinating enzyme 19(gene name synonym)|uniprotkb:Zinc finger MYND domain-containing protein 9(gene name synonym)|uniprotkb:Ubiquitin thioesterase 19(gene name synonym) psi-mi:atad1_human(display_long)|uniprotkb:ATAD1(gene name)|psi-mi:ATAD1(display_short)|uniprotkb:Thorase(gene name synonym)|uniprotkb:FNP001(orf name)|uniprotkb:ATPase family AAA domain-containing protein 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511876|imex:IM-12079-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000172046(gene)|ensembl:ENST00000398888(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0046872"(metal ion binding)|go:"GO:0048642"(negative regulation of skeletal muscle tissue development)|go:"GO:0050821"(protein stabilization)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0090068"(positive regulation of cell cycle process)|go:"GO:1900037"(regulation of cellular response to hypoxia)|go:"GO:1901799"(negative regulation of proteasomal protein catabolic process)|go:"GO:1904292"(regulation of ERAD pathway)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR002893(Zinc finger, MYND-type)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|mint:O94966|rcsb pdb:1WH0|rcsb pdb:4X3G|rcsb pdb:6K7W|rcsb pdb:6KHV|rcsb pdb:6KQV|reactome:R-HSA-5689880|refseq:NP_001186089.1|refseq:NP_001186090.1|refseq:NP_001186091.1|refseq:NP_006668.1|refseq:XP_005264888.1|refseq:XP_016861115.1|refseq:XP_016861122.1 ensembl:ENSG00000138138(gene)|ensembl:ENSG00000283024(gene)|ensembl:ENST00000308448(transcript)|ensembl:ENST00000328142(transcript)|ensembl:ENST00000634773(transcript)|ensembl:ENST00000634970(transcript)|ensembl:ENST00000680024(transcript)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0005524"(ATP binding)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0051967"(negative regulation of synaptic transmission, glutamatergic)|go:"GO:0140567"(transmembrane protein dislocase activity)|go:"GO:0140570"(extraction of mislocalized protein from mitochondrial outer membrane)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR027417|interpro:IPR041569|reactome:R-HSA-9603798|refseq:NP_116199.2|refseq:NP_001308896.1|refseq:XP_005270309.1|refseq:XP_016872336.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:5U3FuLQ44MsWtu7o/3bY7seGC3M9606 rogid:IGkIH4udjuFoshP9hMDDK0ARNOg9606 intact-crc:FA7BFBBC6209D5ED|rigid:C7Rw3YMsYSriRxdgG/b9fsVZKC4 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O94966 uniprotkb:P61619 intact:EBI-2511895|ensembl:ENSP00000381863|uniprotkb:Q641Q9|uniprotkb:Q86XV9|uniprotkb:Q3KQW4|uniprotkb:A6H8U2|uniprotkb:Q6NZY8|uniprotkb:A5PKX8|uniprotkb:B4DGT3|uniprotkb:E7ETS0|uniprotkb:E9PEG8|uniprotkb:B4DTZ0|uniprotkb:E7EN22 intact:EBI-358919|uniprotkb:Q5JPF8|uniprotkb:P38378|uniprotkb:P57726|uniprotkb:Q8N3U3|uniprotkb:Q8NC71|uniprotkb:Q9BU16|uniprotkb:Q9Y2R3|uniprotkb:Q8N0Z4|ensembl:ENSP00000243253 psi-mi:ubp19_human(display_long)|uniprotkb:USP19(gene name)|psi-mi:USP19(display_short)|uniprotkb:KIAA0891(gene name synonym)|uniprotkb:ZMYND9(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 19(gene name synonym)|uniprotkb:Deubiquitinating enzyme 19(gene name synonym)|uniprotkb:Zinc finger MYND domain-containing protein 9(gene name synonym)|uniprotkb:Ubiquitin thioesterase 19(gene name synonym) psi-mi:s61a1_human(display_long)|uniprotkb:SEC61A1(gene name)|psi-mi:SEC61A1(display_short)|uniprotkb:SEC61A(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511876|imex:IM-12079-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000172046(gene)|ensembl:ENST00000398888(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0046872"(metal ion binding)|go:"GO:0048642"(negative regulation of skeletal muscle tissue development)|go:"GO:0050821"(protein stabilization)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0090068"(positive regulation of cell cycle process)|go:"GO:1900037"(regulation of cellular response to hypoxia)|go:"GO:1901799"(negative regulation of proteasomal protein catabolic process)|go:"GO:1904292"(regulation of ERAD pathway)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR002893(Zinc finger, MYND-type)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|mint:O94966|rcsb pdb:1WH0|rcsb pdb:4X3G|rcsb pdb:6K7W|rcsb pdb:6KHV|rcsb pdb:6KQV|reactome:R-HSA-5689880|refseq:NP_001186089.1|refseq:NP_001186090.1|refseq:NP_001186091.1|refseq:NP_006668.1|refseq:XP_005264888.1|refseq:XP_016861115.1|refseq:XP_016861122.1 refseq:NP_037468.1|ensembl:ENSG00000058262(gene)|ensembl:ENST00000243253(transcript)|go:"GO:0005048"(signal sequence binding)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005784"(Sec61 translocon complex)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006613"(cotranslational protein targeting to membrane)|go:"GO:0006614"(SRP-dependent cotranslational protein targeting to membrane)|go:"GO:0006616"(SRP-dependent cotranslational protein targeting to membrane, translocation)|go:"GO:0006620"(posttranslational protein targeting to endoplasmic reticulum membrane)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0008320"(protein transmembrane transporter activity)|go:"GO:0016020"(membrane)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0031204"(posttranslational protein targeting to membrane, translocation)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0039019"(pronephric nephron development)|go:"GO:0043022"(ribosome binding)|go:"GO:0045047"(protein targeting to ER)|interpro:IPR002208(SecY protein)|interpro:IPR019561|interpro:IPR023201|interpro:IPR030659|mint:P61619|rcsb pdb:6W6L|reactome:R-HSA-1236974|reactome:R-HSA-1799339 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:5U3FuLQ44MsWtu7o/3bY7seGC3M9606 rogid:C+EzS02H/FYMX2nyfksXpRMs8G09606 intact-crc:FA7BFBBC6209D5ED|rigid:C7Rw3YMsYSriRxdgG/b9fsVZKC4 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O94966 uniprotkb:O95714 intact:EBI-2511895|ensembl:ENSP00000381863|uniprotkb:Q641Q9|uniprotkb:Q86XV9|uniprotkb:Q3KQW4|uniprotkb:A6H8U2|uniprotkb:Q6NZY8|uniprotkb:A5PKX8|uniprotkb:B4DGT3|uniprotkb:E7ETS0|uniprotkb:E9PEG8|uniprotkb:B4DTZ0|uniprotkb:E7EN22 intact:EBI-1058922|uniprotkb:Q86SV7|uniprotkb:Q86SV8|uniprotkb:Q86SV9|uniprotkb:Q86YY3|uniprotkb:Q86YY4|uniprotkb:Q86YY5|uniprotkb:Q86YY6|uniprotkb:Q86YY7|uniprotkb:Q86YY8|uniprotkb:Q86YY9|uniprotkb:Q86YZ0|uniprotkb:Q86YZ1|intact:EBI-1104961|intact:EBI-28977852|ensembl:ENSP00000261609 psi-mi:ubp19_human(display_long)|uniprotkb:USP19(gene name)|psi-mi:USP19(display_short)|uniprotkb:KIAA0891(gene name synonym)|uniprotkb:ZMYND9(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 19(gene name synonym)|uniprotkb:Deubiquitinating enzyme 19(gene name synonym)|uniprotkb:Zinc finger MYND domain-containing protein 9(gene name synonym)|uniprotkb:Ubiquitin thioesterase 19(gene name synonym) psi-mi:herc2_human(display_long)|uniprotkb:HERC2(gene name)|psi-mi:HERC2(display_short)|uniprotkb:HECT domain and RCC1-like domain-containing protein 2(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase HERC2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511876|imex:IM-12079-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000172046(gene)|ensembl:ENST00000398888(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0046872"(metal ion binding)|go:"GO:0048642"(negative regulation of skeletal muscle tissue development)|go:"GO:0050821"(protein stabilization)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0090068"(positive regulation of cell cycle process)|go:"GO:1900037"(regulation of cellular response to hypoxia)|go:"GO:1901799"(negative regulation of proteasomal protein catabolic process)|go:"GO:1904292"(regulation of ERAD pathway)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR002893(Zinc finger, MYND-type)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|mint:O94966|rcsb pdb:1WH0|rcsb pdb:4X3G|rcsb pdb:6K7W|rcsb pdb:6KHV|rcsb pdb:6KQV|reactome:R-HSA-5689880|refseq:NP_001186089.1|refseq:NP_001186090.1|refseq:NP_001186091.1|refseq:NP_006668.1|refseq:XP_005264888.1|refseq:XP_016861115.1|refseq:XP_016861122.1 ensembl:ENSP00000261609|refseq:NP_004658.3|ensembl:ENSG00000128731(gene)|ensembl:ENST00000261609(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006281"(DNA repair)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032183"(SUMO binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR000433(Zinc finger, ZZ-type)|interpro:IPR000569(HECT)|interpro:IPR001199(Cytochrome b5)|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR006624(Beta-propeller repeat TECPR)|interpro:IPR008979(Galactose-binding like)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR010606(Mib-herc2)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR021097|interpro:IPR035983|interpro:IPR036400|interpro:IPR037252|interpro:IPR037976|interpro:IPR041987|interpro:IPR043145|mint:O95714|rcsb pdb:2KEO|go:"GO:0031625"(ubiquitin protein ligase binding)|rcsb pdb:3KCI|rcsb pdb:4L1M|rcsb pdb:6WW4|reactome:R-HSA-3108214|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473|reactome:R-HSA-983168|rcsb pdb:6WW3|dip:DIP-37632N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:5U3FuLQ44MsWtu7o/3bY7seGC3M9606 rogid:ejMTmb0F9pM7zfHbRscV1rIRgSw9606 intact-crc:FA7BFBBC6209D5ED|rigid:C7Rw3YMsYSriRxdgG/b9fsVZKC4 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O94966 uniprotkb:Q9Y5L0 intact:EBI-2511895|ensembl:ENSP00000381863|uniprotkb:Q641Q9|uniprotkb:Q86XV9|uniprotkb:Q3KQW4|uniprotkb:A6H8U2|uniprotkb:Q6NZY8|uniprotkb:A5PKX8|uniprotkb:B4DGT3|uniprotkb:E7ETS0|uniprotkb:E9PEG8|uniprotkb:B4DTZ0|uniprotkb:E7EN22 intact:EBI-1042571|uniprotkb:A4D1K9|uniprotkb:Q6NUM1|uniprotkb:Q96G71|uniprotkb:Q96GU9|uniprotkb:Q9Y3R2|uniprotkb:C9IZM0|ensembl:ENSP00000265388 psi-mi:ubp19_human(display_long)|uniprotkb:USP19(gene name)|psi-mi:USP19(display_short)|uniprotkb:KIAA0891(gene name synonym)|uniprotkb:ZMYND9(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 19(gene name synonym)|uniprotkb:Deubiquitinating enzyme 19(gene name synonym)|uniprotkb:Zinc finger MYND domain-containing protein 9(gene name synonym)|uniprotkb:Ubiquitin thioesterase 19(gene name synonym) psi-mi:tnpo3_human(display_long)|uniprotkb:TNPO3(gene name)|psi-mi:TNPO3(display_short)|uniprotkb:IPO12(gene name synonym)|uniprotkb:Transportin-SR(gene name synonym)|uniprotkb:Importin-12(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511876|imex:IM-12079-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000172046(gene)|ensembl:ENST00000398888(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0046872"(metal ion binding)|go:"GO:0048642"(negative regulation of skeletal muscle tissue development)|go:"GO:0050821"(protein stabilization)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0090068"(positive regulation of cell cycle process)|go:"GO:1900037"(regulation of cellular response to hypoxia)|go:"GO:1901799"(negative regulation of proteasomal protein catabolic process)|go:"GO:1904292"(regulation of ERAD pathway)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR002893(Zinc finger, MYND-type)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|mint:O94966|rcsb pdb:1WH0|rcsb pdb:4X3G|rcsb pdb:6K7W|rcsb pdb:6KHV|rcsb pdb:6KQV|reactome:R-HSA-5689880|refseq:NP_001186089.1|refseq:NP_001186090.1|refseq:NP_001186091.1|refseq:NP_006668.1|refseq:XP_005264888.1|refseq:XP_016861115.1|refseq:XP_016861122.1 refseq:NP_001177957.2|refseq:NP_036602.1|ensembl:ENSG00000064419(gene)|ensembl:ENST00000265388(transcript)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005642"(annulate lamellae)|go:"GO:0005737"(cytoplasm)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0031267"(small GTPase binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0061608"(nuclear import signal receptor activity)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013598(Exportin-1/Importin-beta-like)|interpro:IPR016024(Armadillo-type fold)|mint:Q9Y5L0|rcsb pdb:4C0O|rcsb pdb:4C0P|rcsb pdb:4C0Q|rcsb pdb:4OL0|rcsb pdb:6GX9 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:5U3FuLQ44MsWtu7o/3bY7seGC3M9606 rogid:Xvd5fZ4wlMc6R6w2wL+JhIOOuIE9606 intact-crc:FA7BFBBC6209D5ED|rigid:C7Rw3YMsYSriRxdgG/b9fsVZKC4 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O94966 uniprotkb:P45954 intact:EBI-2511895|ensembl:ENSP00000381863|uniprotkb:Q641Q9|uniprotkb:Q86XV9|uniprotkb:Q3KQW4|uniprotkb:A6H8U2|uniprotkb:Q6NZY8|uniprotkb:A5PKX8|uniprotkb:B4DGT3|uniprotkb:E7ETS0|uniprotkb:E9PEG8|uniprotkb:B4DTZ0|uniprotkb:E7EN22 intact:EBI-2511905|ensembl:ENSP00000357873|uniprotkb:Q96CX7|uniprotkb:B4DQ51|uniprotkb:Q5SQN6 psi-mi:ubp19_human(display_long)|uniprotkb:USP19(gene name)|psi-mi:USP19(display_short)|uniprotkb:KIAA0891(gene name synonym)|uniprotkb:ZMYND9(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 19(gene name synonym)|uniprotkb:Deubiquitinating enzyme 19(gene name synonym)|uniprotkb:Zinc finger MYND domain-containing protein 9(gene name synonym)|uniprotkb:Ubiquitin thioesterase 19(gene name synonym) psi-mi:acdsb_human(display_long)|uniprotkb:ACADSB(gene name)|psi-mi:ACADSB(display_short)|uniprotkb:2-methyl branched chain acyl-CoA dehydrogenase(gene name synonym)|uniprotkb:2-methylbutyryl-coenzyme A dehydrogenase(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511876|imex:IM-12079-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000172046(gene)|ensembl:ENST00000398888(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0046872"(metal ion binding)|go:"GO:0048642"(negative regulation of skeletal muscle tissue development)|go:"GO:0050821"(protein stabilization)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0090068"(positive regulation of cell cycle process)|go:"GO:1900037"(regulation of cellular response to hypoxia)|go:"GO:1901799"(negative regulation of proteasomal protein catabolic process)|go:"GO:1904292"(regulation of ERAD pathway)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR002893(Zinc finger, MYND-type)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|mint:O94966|rcsb pdb:1WH0|rcsb pdb:4X3G|rcsb pdb:6K7W|rcsb pdb:6KHV|rcsb pdb:6KQV|reactome:R-HSA-5689880|refseq:NP_001186089.1|refseq:NP_001186090.1|refseq:NP_001186091.1|refseq:NP_006668.1|refseq:XP_005264888.1|refseq:XP_016861115.1|refseq:XP_016861122.1 ensembl:ENSG00000196177(gene)|ensembl:ENST00000358776(transcript)|go:"GO:0003853"(2-methylacyl-CoA dehydrogenase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006550"(isoleucine catabolic process)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0016937"(short-branched-chain-acyl-CoA dehydrogenase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0050660"(flavin adenine dinucleotide binding)|go:"GO:0102035"("isobutyryl-CoA:FAD oxidoreductase activity")|interpro:IPR006089(Acyl-CoA dehydrogenase, conserved site)|interpro:IPR006091(Acyl-CoA dehydrogenase/oxidase, central region)|interpro:IPR009075(Acyl-CoA dehydrogenase/oxidase C-terminal)|interpro:IPR009100(Acyl-CoA dehydrogenase/oxidase, middle and N-terminal)|interpro:IPR013786(Acyl-CoA dehydrogenase/oxidase, N-terminal)|interpro:IPR036250|interpro:IPR037069|rcsb pdb:2JIF|reactome:R-HSA-70895|refseq:NP_001600.1|refseq:NP_001317103.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:5U3FuLQ44MsWtu7o/3bY7seGC3M9606 rogid:phnlWtZGT21VyKrhWj9a3Wjfijw9606 intact-crc:FA7BFBBC6209D5ED|rigid:C7Rw3YMsYSriRxdgG/b9fsVZKC4 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O94966 uniprotkb:P30519 intact:EBI-2511895|ensembl:ENSP00000381863|uniprotkb:Q641Q9|uniprotkb:Q86XV9|uniprotkb:Q3KQW4|uniprotkb:A6H8U2|uniprotkb:Q6NZY8|uniprotkb:A5PKX8|uniprotkb:B4DGT3|uniprotkb:E7ETS0|uniprotkb:E9PEG8|uniprotkb:B4DTZ0|uniprotkb:E7EN22 intact:EBI-712096|uniprotkb:I3L430|ensembl:ENSP00000219700|ensembl:ENSP00000381595|ensembl:ENSP00000385100|ensembl:ENSP00000391637|ensembl:ENSP00000394103|ensembl:ENSP00000459214|ensembl:ENSP00000478785|ensembl:ENSP00000481295|ensembl:ENSP00000481811|ensembl:ENSP00000483319|ensembl:ENSP00000484422|ensembl:ENSP00000484423|ensembl:ENSP00000484467|ensembl:ENSP00000487673|ensembl:ENSP00000488579|ensembl:ENSP00000488880|uniprotkb:O60605|uniprotkb:A8MT35|uniprotkb:D3DUD5 psi-mi:ubp19_human(display_long)|uniprotkb:USP19(gene name)|psi-mi:USP19(display_short)|uniprotkb:KIAA0891(gene name synonym)|uniprotkb:ZMYND9(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 19(gene name synonym)|uniprotkb:Deubiquitinating enzyme 19(gene name synonym)|uniprotkb:Zinc finger MYND domain-containing protein 9(gene name synonym)|uniprotkb:Ubiquitin thioesterase 19(gene name synonym) psi-mi:hmox2_human(display_long)|uniprotkb:HMOX2(gene name)|psi-mi:HMOX2(display_short)|uniprotkb:HO2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511876|imex:IM-12079-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000172046(gene)|ensembl:ENST00000398888(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0046872"(metal ion binding)|go:"GO:0048642"(negative regulation of skeletal muscle tissue development)|go:"GO:0050821"(protein stabilization)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0090068"(positive regulation of cell cycle process)|go:"GO:1900037"(regulation of cellular response to hypoxia)|go:"GO:1901799"(negative regulation of proteasomal protein catabolic process)|go:"GO:1904292"(regulation of ERAD pathway)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR002893(Zinc finger, MYND-type)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|mint:O94966|rcsb pdb:1WH0|rcsb pdb:4X3G|rcsb pdb:6K7W|rcsb pdb:6KHV|rcsb pdb:6KQV|reactome:R-HSA-5689880|refseq:NP_001186089.1|refseq:NP_001186090.1|refseq:NP_001186091.1|refseq:NP_006668.1|refseq:XP_005264888.1|refseq:XP_016861115.1|refseq:XP_016861122.1 refseq:NP_001273196.1|refseq:NP_001273197.1|refseq:NP_001273198.1|refseq:NP_001273199.1|refseq:NP_001273200.1|ensembl:ENSG00000103415(gene)|ensembl:ENSG00000277424(gene)|ensembl:ENST00000219700(transcript)|ensembl:ENST00000398595(transcript)|ensembl:ENST00000406590(transcript)|ensembl:ENST00000414777(transcript)|ensembl:ENST00000458134(transcript)|ensembl:ENST00000570646(transcript)|ensembl:ENST00000612525(transcript)|ensembl:ENST00000615778(transcript)|ensembl:ENST00000619528(transcript)|ensembl:ENST00000619913(transcript)|ensembl:ENST00000620445(transcript)|ensembl:ENST00000621065(transcript)|ensembl:ENST00000622146(transcript)|ensembl:ENST00000631540(transcript)|ensembl:ENST00000631677(transcript)|ensembl:ENST00000632458(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0004392"("heme oxygenase (decyclizing) activity")|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006788"(heme oxidation)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0016020"(membrane)|go:"GO:0020037"(heme binding)|go:"GO:0035579"(specific granule membrane)|go:"GO:0042167"(heme catabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0055072"(iron ion homeostasis)|interpro:IPR002051(Haem oxygenase)|interpro:IPR016053(Haem oxygenase-like)|interpro:IPR016084(Haem oxygenase-like, multi-helical)|interpro:IPR018207|rcsb pdb:4WMH|rcsb pdb:5UC8|rcsb pdb:5UC9|rcsb pdb:5UCA|reactome:R-HSA-189483|reactome:R-HSA-6798695|reactome:R-HSA-8980692|reactome:R-HSA-917937|reactome:R-HSA-9707564|mint:P30519|rcsb pdb:2Q32|rcsb pdb:2QPP|rcsb pdb:2RGZ|refseq:NP_001120676.1|refseq:NP_001120677.1|refseq:NP_001120678.1|refseq:NP_002125.3|refseq:XP_016878685.1|refseq:XP_016878686.1|dip:DIP-53564N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:5U3FuLQ44MsWtu7o/3bY7seGC3M9606 rogid:yTwXdEjnQgfiFBvl5fhcCwDOJWo9606 intact-crc:FA7BFBBC6209D5ED|rigid:C7Rw3YMsYSriRxdgG/b9fsVZKC4 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O94966 uniprotkb:Q96I99 intact:EBI-2511895|ensembl:ENSP00000381863|uniprotkb:Q641Q9|uniprotkb:Q86XV9|uniprotkb:Q3KQW4|uniprotkb:A6H8U2|uniprotkb:Q6NZY8|uniprotkb:A5PKX8|uniprotkb:B4DGT3|uniprotkb:E7ETS0|uniprotkb:E9PEG8|uniprotkb:B4DTZ0|uniprotkb:E7EN22 intact:EBI-2511878|ensembl:ENSP00000307432|uniprotkb:Q8WUQ1|uniprotkb:Q86VX8|uniprotkb:O95195|uniprotkb:Q6NUH7|uniprotkb:C9JVT2 psi-mi:ubp19_human(display_long)|uniprotkb:USP19(gene name)|psi-mi:USP19(display_short)|uniprotkb:KIAA0891(gene name synonym)|uniprotkb:ZMYND9(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 19(gene name synonym)|uniprotkb:Deubiquitinating enzyme 19(gene name synonym)|uniprotkb:Zinc finger MYND domain-containing protein 9(gene name synonym)|uniprotkb:Ubiquitin thioesterase 19(gene name synonym) psi-mi:sucb2_human(display_long)|uniprotkb:SUCLG2(gene name)|psi-mi:SUCLG2(display_short)|uniprotkb:GTP-specific succinyl-CoA synthetase subunit beta(gene name synonym)|uniprotkb:Succinyl-CoA synthetase beta-G chain(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511876|imex:IM-12079-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000172046(gene)|ensembl:ENST00000398888(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0046872"(metal ion binding)|go:"GO:0048642"(negative regulation of skeletal muscle tissue development)|go:"GO:0050821"(protein stabilization)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0090068"(positive regulation of cell cycle process)|go:"GO:1900037"(regulation of cellular response to hypoxia)|go:"GO:1901799"(negative regulation of proteasomal protein catabolic process)|go:"GO:1904292"(regulation of ERAD pathway)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR002893(Zinc finger, MYND-type)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|mint:O94966|rcsb pdb:1WH0|rcsb pdb:4X3G|rcsb pdb:6K7W|rcsb pdb:6KHV|rcsb pdb:6KQV|reactome:R-HSA-5689880|refseq:NP_001186089.1|refseq:NP_001186090.1|refseq:NP_001186091.1|refseq:NP_006668.1|refseq:XP_005264888.1|refseq:XP_016861115.1|refseq:XP_016861122.1 ensembl:ENSG00000172340(gene)|ensembl:ENST00000307227(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004775"("succinate-CoA ligase (ADP-forming) activity")|go:"GO:0004776"("succinate-CoA ligase (GDP-forming) activity")|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005886"(plasma membrane)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006104"(succinyl-CoA metabolic process)|go:"GO:0006105"(succinate metabolic process)|go:"GO:0019003"(GDP binding)|go:"GO:0042709"(succinate-CoA ligase complex)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045244"("succinate-CoA ligase complex (GDP-forming)")|interpro:IPR005811(ATP-citrate lyase/succinyl-CoA ligase)|interpro:IPR013650(ATP-grasp fold, succinyl-CoA synthetase-type)|interpro:IPR013815(ATP-grasp fold, subdomain 1)|interpro:IPR005809(Succinyl-CoA synthetase, beta subunit)|interpro:IPR016102(Succinyl-CoA synthetase-like)|interpro:IPR017866|interpro:IPR034722|mint:Q96I99|rcsb pdb:6WCV|reactome:R-HSA-71403|refseq:NP_001171070.1|refseq:NP_003839.2|dip:DIP-53563N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:5U3FuLQ44MsWtu7o/3bY7seGC3M9606 rogid:jxrFGuu3hFn2QAYfrPxTKhScM249606 intact-crc:FA7BFBBC6209D5ED|rigid:C7Rw3YMsYSriRxdgG/b9fsVZKC4 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O94966 uniprotkb:Q14318 intact:EBI-2511895|ensembl:ENSP00000381863|uniprotkb:Q641Q9|uniprotkb:Q86XV9|uniprotkb:Q3KQW4|uniprotkb:A6H8U2|uniprotkb:Q6NZY8|uniprotkb:A5PKX8|uniprotkb:B4DGT3|uniprotkb:E7ETS0|uniprotkb:E9PEG8|uniprotkb:B4DTZ0|uniprotkb:E7EN22 intact:EBI-724839|uniprotkb:Q53GU3|uniprotkb:Q7Z349|uniprotkb:Q86YK6|ensembl:ENSP00000222308|ensembl:ENSP00000472302|uniprotkb:C8C9T5 psi-mi:ubp19_human(display_long)|uniprotkb:USP19(gene name)|psi-mi:USP19(display_short)|uniprotkb:KIAA0891(gene name synonym)|uniprotkb:ZMYND9(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 19(gene name synonym)|uniprotkb:Deubiquitinating enzyme 19(gene name synonym)|uniprotkb:Zinc finger MYND domain-containing protein 9(gene name synonym)|uniprotkb:Ubiquitin thioesterase 19(gene name synonym) psi-mi:fkbp8_human(display_long)|uniprotkb:FK506-binding protein 8(gene name synonym)|uniprotkb:38 kDa FK506-binding protein(gene name synonym)|uniprotkb:FKBPR38(gene name synonym)|uniprotkb:FKBP8(gene name)|psi-mi:FKBP8(display_short)|uniprotkb:FKBP38(gene name synonym)|uniprotkb:Rotamase(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511876|imex:IM-12079-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000172046(gene)|ensembl:ENST00000398888(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0046872"(metal ion binding)|go:"GO:0048642"(negative regulation of skeletal muscle tissue development)|go:"GO:0050821"(protein stabilization)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0090068"(positive regulation of cell cycle process)|go:"GO:1900037"(regulation of cellular response to hypoxia)|go:"GO:1901799"(negative regulation of proteasomal protein catabolic process)|go:"GO:1904292"(regulation of ERAD pathway)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR002893(Zinc finger, MYND-type)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|mint:O94966|rcsb pdb:1WH0|rcsb pdb:4X3G|rcsb pdb:6K7W|rcsb pdb:6KHV|rcsb pdb:6KQV|reactome:R-HSA-5689880|refseq:NP_001186089.1|refseq:NP_001186090.1|refseq:NP_001186091.1|refseq:NP_006668.1|refseq:XP_005264888.1|refseq:XP_016861115.1|refseq:XP_016861122.1 refseq:NP_036313.3|refseq:NP_001295302.1|go:"GO:0001708"(cell fate specification)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006915"(apoptotic process)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0021904"(dorsal/ventral neural tube patterning)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0046872"(metal ion binding)|go:"GO:0097718"(disordered domain specific binding)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013105(Tetratricopeptide TPR2)|interpro:IPR019734|mint:Q14318|ensembl:ENSG00000105701(gene)|rcsb pdb:2AWG|rcsb pdb:2D9F|rcsb pdb:2F2D|rcsb pdb:2MF9|rcsb pdb:3EY6|rcsb pdb:5MGX|reactome:R-HSA-5689880|ensembl:ENST00000222308(transcript)|ensembl:ENST00000596558(transcript)|refseq:XP_011526165.1|dip:DIP-42200N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:5U3FuLQ44MsWtu7o/3bY7seGC3M9606 rogid:CpZqwry5szPluwNMwWXshCIMUvY9606 intact-crc:FA7BFBBC6209D5ED|rigid:C7Rw3YMsYSriRxdgG/b9fsVZKC4 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O94966 uniprotkb:P19474 intact:EBI-2511895|ensembl:ENSP00000381863|uniprotkb:Q641Q9|uniprotkb:Q86XV9|uniprotkb:Q3KQW4|uniprotkb:A6H8U2|uniprotkb:Q6NZY8|uniprotkb:A5PKX8|uniprotkb:B4DGT3|uniprotkb:E7ETS0|uniprotkb:E9PEG8|uniprotkb:B4DTZ0|uniprotkb:E7EN22 intact:EBI-81290|uniprotkb:Q96RF8|uniprotkb:Q5XPV5|ensembl:ENSP00000254436 psi-mi:ubp19_human(display_long)|uniprotkb:USP19(gene name)|psi-mi:USP19(display_short)|uniprotkb:KIAA0891(gene name synonym)|uniprotkb:ZMYND9(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 19(gene name synonym)|uniprotkb:Deubiquitinating enzyme 19(gene name synonym)|uniprotkb:Zinc finger MYND domain-containing protein 9(gene name synonym)|uniprotkb:Ubiquitin thioesterase 19(gene name synonym) psi-mi:ro52_human(display_long)|uniprotkb:TRIM21(gene name)|psi-mi:TRIM21(display_short)|uniprotkb:RNF81(gene name synonym)|uniprotkb:Sjoegren syndrome type A antigen(gene name synonym)|uniprotkb:"Ro(SS-A)"(gene name synonym)|uniprotkb:52 kDa ribonucleoprotein autoantigen Ro/SS-A(gene name synonym)|uniprotkb:Tripartite motif-containing protein 21(gene name synonym)|uniprotkb:RING finger protein 81(gene name synonym)|uniprotkb:52 kDa Ro protein(gene name synonym)|uniprotkb:RO52(gene name synonym)|uniprotkb:SSA1(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TRIM21(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511876|imex:IM-12079-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000172046(gene)|ensembl:ENST00000398888(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0046872"(metal ion binding)|go:"GO:0048642"(negative regulation of skeletal muscle tissue development)|go:"GO:0050821"(protein stabilization)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0090068"(positive regulation of cell cycle process)|go:"GO:1900037"(regulation of cellular response to hypoxia)|go:"GO:1901799"(negative regulation of proteasomal protein catabolic process)|go:"GO:1904292"(regulation of ERAD pathway)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR002893(Zinc finger, MYND-type)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|mint:O94966|rcsb pdb:1WH0|rcsb pdb:4X3G|rcsb pdb:6K7W|rcsb pdb:6KHV|rcsb pdb:6KQV|reactome:R-HSA-5689880|refseq:NP_001186089.1|refseq:NP_001186090.1|refseq:NP_001186091.1|refseq:NP_006668.1|refseq:XP_005264888.1|refseq:XP_016861115.1|refseq:XP_016861122.1 refseq:NP_003132.2|go:"GO:0019901"(protein kinase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031648"(protein destabilization)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032479"(regulation of type I interferon production)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032897"(negative regulation of viral transcription)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045087"(innate immune response)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0045824"(negative regulation of innate immune response)|go:"GO:0046596"(regulation of viral entry into host cell)|go:"GO:0046598"(positive regulation of viral entry into host cell)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0090086"(negative regulation of protein deubiquitination)|ensembl:ENSG00000132109(gene)|ensembl:ENST00000254436(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000932"(P-body)|go:"GO:0003677"(DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0007049"(cell cycle)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0016567"(protein ubiquitination)|interpro:IPR006574(SPRY-associated)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR017907|interpro:IPR020457|interpro:IPR035831|interpro:IPR043136|mint:P19474|rcsb pdb:2IWG|rcsb pdb:5JPX|rcsb pdb:5OLM|rcsb pdb:6FGA|rcsb pdb:6S53|rcsb pdb:7BBD|reactome:R-HSA-1834941|reactome:R-HSA-3134975|reactome:R-HSA-877300|reactome:R-HSA-983168|go:"GO:1902187"|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000315(Zinc finger, B-box)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003613(U box)|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR003879(Butyrophylin-like) psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:5U3FuLQ44MsWtu7o/3bY7seGC3M9606 rogid:/9rpwdudXQWv8z8JLmRecXf3YQM9606 intact-crc:FA7BFBBC6209D5ED|rigid:C7Rw3YMsYSriRxdgG/b9fsVZKC4 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O94966 uniprotkb:Q96JN8 intact:EBI-2511895|ensembl:ENSP00000381863|uniprotkb:Q641Q9|uniprotkb:Q86XV9|uniprotkb:Q3KQW4|uniprotkb:A6H8U2|uniprotkb:Q6NZY8|uniprotkb:A5PKX8|uniprotkb:B4DGT3|uniprotkb:E7ETS0|uniprotkb:E9PEG8|uniprotkb:B4DTZ0|uniprotkb:E7EN22 intact:EBI-1053406|uniprotkb:Q6GPI8|uniprotkb:Q96IU9|uniprotkb:Q9H0B0|intact:EBI-2563327|intact:EBI-28979128|ensembl:ENSP00000382390|ensembl:ENSP00000500916 psi-mi:ubp19_human(display_long)|uniprotkb:USP19(gene name)|psi-mi:USP19(display_short)|uniprotkb:KIAA0891(gene name synonym)|uniprotkb:ZMYND9(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 19(gene name synonym)|uniprotkb:Deubiquitinating enzyme 19(gene name synonym)|uniprotkb:Zinc finger MYND domain-containing protein 9(gene name synonym)|uniprotkb:Ubiquitin thioesterase 19(gene name synonym) psi-mi:neul4_human(display_long)|uniprotkb:NEURL4(gene name)|psi-mi:NEURL4(display_short)|uniprotkb:KIAA1787(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511876|imex:IM-12079-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000172046(gene)|ensembl:ENST00000398888(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0046872"(metal ion binding)|go:"GO:0048642"(negative regulation of skeletal muscle tissue development)|go:"GO:0050821"(protein stabilization)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0090068"(positive regulation of cell cycle process)|go:"GO:1900037"(regulation of cellular response to hypoxia)|go:"GO:1901799"(negative regulation of proteasomal protein catabolic process)|go:"GO:1904292"(regulation of ERAD pathway)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR002893(Zinc finger, MYND-type)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|mint:O94966|rcsb pdb:1WH0|rcsb pdb:4X3G|rcsb pdb:6K7W|rcsb pdb:6KHV|rcsb pdb:6KQV|reactome:R-HSA-5689880|refseq:NP_001186089.1|refseq:NP_001186090.1|refseq:NP_001186091.1|refseq:NP_006668.1|refseq:XP_005264888.1|refseq:XP_016861115.1|refseq:XP_016861122.1 refseq:NP_001005408.1|refseq:NP_115818.2|ensembl:ENST00000315614|ensembl:ENSP00000319826|ensembl:ENSP00000382390|ensembl:ENSP00000500916|ensembl:ENST00000673081|ensembl:ENSP00000500667|ensembl:ENSG00000215041(gene)|ensembl:ENSG00000288301(gene)|ensembl:ENST00000399464(transcript)|ensembl:ENST00000671847(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005814"(centriole)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR006573(NEUZ)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR037962|interpro:IPR043136|mint:Q96JN8|rcsb pdb:2E63 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:5U3FuLQ44MsWtu7o/3bY7seGC3M9606 rogid:lydZRBsnJDyAdaDjTe7gJVkxL149606 intact-crc:FA7BFBBC6209D5ED|rigid:C7Rw3YMsYSriRxdgG/b9fsVZKC4 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O94966 intact:EBI-2509429 intact:EBI-2511895|ensembl:ENSP00000381863|uniprotkb:Q641Q9|uniprotkb:Q86XV9|uniprotkb:Q3KQW4|uniprotkb:A6H8U2|uniprotkb:Q6NZY8|uniprotkb:A5PKX8|uniprotkb:B4DGT3|uniprotkb:E7ETS0|uniprotkb:E9PEG8|uniprotkb:B4DTZ0|uniprotkb:E7EN22 uniparc:UPI0000D61C21 psi-mi:ubp19_human(display_long)|uniprotkb:USP19(gene name)|psi-mi:USP19(display_short)|uniprotkb:KIAA0891(gene name synonym)|uniprotkb:ZMYND9(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 19(gene name synonym)|uniprotkb:Deubiquitinating enzyme 19(gene name synonym)|uniprotkb:Zinc finger MYND domain-containing protein 9(gene name synonym)|uniprotkb:Ubiquitin thioesterase 19(gene name synonym) psi-mi:ipi00748750(display_short)|psi-mi:EBI-2509429(display_long) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511876|imex:IM-12079-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000172046(gene)|ensembl:ENST00000398888(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0046872"(metal ion binding)|go:"GO:0048642"(negative regulation of skeletal muscle tissue development)|go:"GO:0050821"(protein stabilization)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0090068"(positive regulation of cell cycle process)|go:"GO:1900037"(regulation of cellular response to hypoxia)|go:"GO:1901799"(negative regulation of proteasomal protein catabolic process)|go:"GO:1904292"(regulation of ERAD pathway)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR002893(Zinc finger, MYND-type)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|mint:O94966|rcsb pdb:1WH0|rcsb pdb:4X3G|rcsb pdb:6K7W|rcsb pdb:6KHV|rcsb pdb:6KQV|reactome:R-HSA-5689880|refseq:NP_001186089.1|refseq:NP_001186090.1|refseq:NP_001186091.1|refseq:NP_006668.1|refseq:XP_005264888.1|refseq:XP_016861115.1|refseq:XP_016861122.1 - psi-mi:"MI:0469"(intact) - no-uniprot-update:An amino acid sequence which is not represented in UniProt figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:5U3FuLQ44MsWtu7o/3bY7seGC3M9606 rogid:2Zu89xL1Kha5zUXHHacKo7QGjaQ9606 intact-crc:FA7BFBBC6209D5ED|rigid:C7Rw3YMsYSriRxdgG/b9fsVZKC4 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O94966 uniprotkb:P57088 intact:EBI-2511895|ensembl:ENSP00000381863|uniprotkb:Q641Q9|uniprotkb:Q86XV9|uniprotkb:Q3KQW4|uniprotkb:A6H8U2|uniprotkb:Q6NZY8|uniprotkb:A5PKX8|uniprotkb:B4DGT3|uniprotkb:E7ETS0|uniprotkb:E9PEG8|uniprotkb:B4DTZ0|uniprotkb:E7EN22 intact:EBI-1048629|uniprotkb:Q9H953|uniprotkb:B3KSS8|ensembl:ENSP00000422473|ensembl:ENSP00000427006|ensembl:ENSP00000441455 psi-mi:ubp19_human(display_long)|uniprotkb:USP19(gene name)|psi-mi:USP19(display_short)|uniprotkb:KIAA0891(gene name synonym)|uniprotkb:ZMYND9(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 19(gene name synonym)|uniprotkb:Deubiquitinating enzyme 19(gene name synonym)|uniprotkb:Zinc finger MYND domain-containing protein 9(gene name synonym)|uniprotkb:Ubiquitin thioesterase 19(gene name synonym) psi-mi:tmm33_human(display_long)|uniprotkb:Protein DB83(gene name synonym)|uniprotkb:TMEM33(gene name)|psi-mi:TMEM33(display_short)|uniprotkb:DB83(gene name synonym)|uniprotkb:SHINC-3(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511876|imex:IM-12079-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000172046(gene)|ensembl:ENST00000398888(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0046872"(metal ion binding)|go:"GO:0048642"(negative regulation of skeletal muscle tissue development)|go:"GO:0050821"(protein stabilization)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0090068"(positive regulation of cell cycle process)|go:"GO:1900037"(regulation of cellular response to hypoxia)|go:"GO:1901799"(negative regulation of proteasomal protein catabolic process)|go:"GO:1904292"(regulation of ERAD pathway)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR002893(Zinc finger, MYND-type)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|mint:O94966|rcsb pdb:1WH0|rcsb pdb:4X3G|rcsb pdb:6K7W|rcsb pdb:6KHV|rcsb pdb:6KQV|reactome:R-HSA-5689880|refseq:NP_001186089.1|refseq:NP_001186090.1|refseq:NP_001186091.1|refseq:NP_006668.1|refseq:XP_005264888.1|refseq:XP_016861115.1|refseq:XP_016861122.1 refseq:NP_060596.2|refseq:XP_005248173.1|refseq:XP_005248174.1|ensembl:ENSG00000109133(gene)|ensembl:ENST00000325094(transcript)|ensembl:ENST00000504986(transcript)|ensembl:ENST00000513702(transcript)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0042470"(melanosome)|go:"GO:0061024"(membrane organization)|go:"GO:0071786"(endoplasmic reticulum tubular network organization)|go:"GO:1903371"(regulation of endoplasmic reticulum tubular network organization)|go:"GO:1903896"(positive regulation of IRE1-mediated unfolded protein response)|go:"GO:1903899"(positive regulation of PERK-mediated unfolded protein response)|interpro:IPR005344(Protein of unknown function UPF0121)|mint:P57088 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:5U3FuLQ44MsWtu7o/3bY7seGC3M9606 rogid:FGc4/gpnYoRtlDJMxQWh5hXe5Ko9606 intact-crc:FA7BFBBC6209D5ED|rigid:C7Rw3YMsYSriRxdgG/b9fsVZKC4 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O94966 uniprotkb:Q9H3U1 intact:EBI-2511895|ensembl:ENSP00000381863|uniprotkb:Q641Q9|uniprotkb:Q86XV9|uniprotkb:Q3KQW4|uniprotkb:A6H8U2|uniprotkb:Q6NZY8|uniprotkb:A5PKX8|uniprotkb:B4DGT3|uniprotkb:E7ETS0|uniprotkb:E9PEG8|uniprotkb:B4DTZ0|uniprotkb:E7EN22 intact:EBI-1048763|uniprotkb:Q7L3Y6|uniprotkb:Q9H3U8|uniprotkb:Q9NSE8|uniprotkb:Q9NSE9|uniprotkb:A8K6F7|ensembl:ENSP00000407487 psi-mi:ubp19_human(display_long)|uniprotkb:USP19(gene name)|psi-mi:USP19(display_short)|uniprotkb:KIAA0891(gene name synonym)|uniprotkb:ZMYND9(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 19(gene name synonym)|uniprotkb:Deubiquitinating enzyme 19(gene name synonym)|uniprotkb:Zinc finger MYND domain-containing protein 9(gene name synonym)|uniprotkb:Ubiquitin thioesterase 19(gene name synonym) psi-mi:un45a_human(display_long)|uniprotkb:GCUNC-45(gene name synonym)|uniprotkb:Smooth muscle cell-associated protein 1(gene name synonym)|uniprotkb:UNC45A(gene name)|psi-mi:UNC45A(display_short)|uniprotkb:SMAP1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511876|imex:IM-12079-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000172046(gene)|ensembl:ENST00000398888(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0046872"(metal ion binding)|go:"GO:0048642"(negative regulation of skeletal muscle tissue development)|go:"GO:0050821"(protein stabilization)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0090068"(positive regulation of cell cycle process)|go:"GO:1900037"(regulation of cellular response to hypoxia)|go:"GO:1901799"(negative regulation of proteasomal protein catabolic process)|go:"GO:1904292"(regulation of ERAD pathway)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR002893(Zinc finger, MYND-type)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|mint:O94966|rcsb pdb:1WH0|rcsb pdb:4X3G|rcsb pdb:6K7W|rcsb pdb:6KHV|rcsb pdb:6KQV|reactome:R-HSA-5689880|refseq:NP_001186089.1|refseq:NP_001186090.1|refseq:NP_001186091.1|refseq:NP_006668.1|refseq:XP_005264888.1|refseq:XP_016861115.1|refseq:XP_016861122.1 refseq:NP_001034764.1|refseq:NP_061141.2|refseq:XP_011520081.1|ensembl:ENSG00000140553(gene)|ensembl:ENST00000418476(transcript)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0007517"(muscle organ development)|go:"GO:0016607"(nuclear speck)|go:"GO:0030154"(cell differentiation)|go:"GO:0045296"(cadherin binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR019734|interpro:IPR024660|rcsb pdb:2DBA|refseq:NP_001310548.1|refseq:NP_001310550.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:5U3FuLQ44MsWtu7o/3bY7seGC3M9606 rogid:P/N+VqGUtK2vWzHyKq6UzC4xxdo9606 intact-crc:FA7BFBBC6209D5ED|rigid:C7Rw3YMsYSriRxdgG/b9fsVZKC4 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O94966 uniprotkb:P06737 intact:EBI-2511895|ensembl:ENSP00000381863|uniprotkb:Q641Q9|uniprotkb:Q86XV9|uniprotkb:Q3KQW4|uniprotkb:A6H8U2|uniprotkb:Q6NZY8|uniprotkb:A5PKX8|uniprotkb:B4DGT3|uniprotkb:E7ETS0|uniprotkb:E9PEG8|uniprotkb:B4DTZ0|uniprotkb:E7EN22 intact:EBI-2511865|ensembl:ENSP00000216392|uniprotkb:O60567|uniprotkb:O60913|uniprotkb:O60752|uniprotkb:A6NDQ4|uniprotkb:Q501V9|uniprotkb:Q96G82|uniprotkb:Q641R5|uniprotkb:B4DUB7|uniprotkb:F5H816 psi-mi:ubp19_human(display_long)|uniprotkb:USP19(gene name)|psi-mi:USP19(display_short)|uniprotkb:KIAA0891(gene name synonym)|uniprotkb:ZMYND9(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 19(gene name synonym)|uniprotkb:Deubiquitinating enzyme 19(gene name synonym)|uniprotkb:Zinc finger MYND domain-containing protein 9(gene name synonym)|uniprotkb:Ubiquitin thioesterase 19(gene name synonym) psi-mi:pygl_human(display_long)|uniprotkb:PYGL(gene name)|psi-mi:PYGL(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511876|imex:IM-12079-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000172046(gene)|ensembl:ENST00000398888(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0046872"(metal ion binding)|go:"GO:0048642"(negative regulation of skeletal muscle tissue development)|go:"GO:0050821"(protein stabilization)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0090068"(positive regulation of cell cycle process)|go:"GO:1900037"(regulation of cellular response to hypoxia)|go:"GO:1901799"(negative regulation of proteasomal protein catabolic process)|go:"GO:1904292"(regulation of ERAD pathway)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR002893(Zinc finger, MYND-type)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|mint:O94966|rcsb pdb:1WH0|rcsb pdb:4X3G|rcsb pdb:6K7W|rcsb pdb:6KHV|rcsb pdb:6KQV|reactome:R-HSA-5689880|refseq:NP_001186089.1|refseq:NP_001186090.1|refseq:NP_001186091.1|refseq:NP_006668.1|refseq:XP_005264888.1|refseq:XP_016861115.1|refseq:XP_016861122.1 ensembl:ENSG00000100504(gene)|ensembl:ENST00000216392(transcript)|go:"GO:0002060"(purine nucleobase binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005536"(glucose binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0005980"(glycogen catabolic process)|go:"GO:0006015"(5-phosphoribose 1-diphosphate biosynthetic process)|go:"GO:0008184"(glycogen phosphorylase activity)|go:"GO:0009617"(response to bacterium)|go:"GO:0016208"(AMP binding)|go:"GO:0019842"(vitamin binding)|go:"GO:0030170"(pyridoxal phosphate binding)|go:"GO:0032052"(bile acid binding)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070266"(necroptotic process)|go:"GO:0102250"(linear malto-oligosaccharide phosphorylase activity)|go:"GO:0102499"(SHG alpha-glucan phosphorylase activity)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000811(Glycosyl transferase, family 35)|interpro:IPR011833(Glycogen/starch/alpha-glucan phosphorylase)|interpro:IPR035090|mint:P06737|rcsb pdb:1EM6|rcsb pdb:1EXV|rcsb pdb:1FA9|rcsb pdb:1FC0|rcsb pdb:1L5Q|rcsb pdb:1L5R|rcsb pdb:1L5S|rcsb pdb:1L7X|rcsb pdb:1XOI|rcsb pdb:2ATI|rcsb pdb:2QLL|rcsb pdb:2ZB2|rcsb pdb:3CEH|rcsb pdb:3CEJ|rcsb pdb:3CEM|rcsb pdb:3DD1|rcsb pdb:3DDS|rcsb pdb:3DDW|reactome:R-HSA-70221|reactome:R-HSA-6798695|refseq:NP_001157412.1|refseq:NP_002854.3 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:5U3FuLQ44MsWtu7o/3bY7seGC3M9606 rogid:8h3TR7UB7SC/CFh5TXcjHvE/C709606 intact-crc:FA7BFBBC6209D5ED|rigid:C7Rw3YMsYSriRxdgG/b9fsVZKC4 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O94966 uniprotkb:Q12769 intact:EBI-2511895|ensembl:ENSP00000381863|uniprotkb:Q641Q9|uniprotkb:Q86XV9|uniprotkb:Q3KQW4|uniprotkb:A6H8U2|uniprotkb:Q6NZY8|uniprotkb:A5PKX8|uniprotkb:B4DGT3|uniprotkb:E7ETS0|uniprotkb:E9PEG8|uniprotkb:B4DTZ0|uniprotkb:E7EN22 intact:EBI-295715|uniprotkb:Q96GB3|uniprotkb:Q9H660|uniprotkb:B4DYE8|uniprotkb:B4E2J9|uniprotkb:Q08AD3|uniprotkb:Q7Z5X6|intact:EBI-2563140|ensembl:ENSP00000367721 psi-mi:ubp19_human(display_long)|uniprotkb:USP19(gene name)|psi-mi:USP19(display_short)|uniprotkb:KIAA0891(gene name synonym)|uniprotkb:ZMYND9(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 19(gene name synonym)|uniprotkb:Deubiquitinating enzyme 19(gene name synonym)|uniprotkb:Zinc finger MYND domain-containing protein 9(gene name synonym)|uniprotkb:Ubiquitin thioesterase 19(gene name synonym) psi-mi:nu160_human(display_long)|uniprotkb:NUP160(gene name)|psi-mi:NUP160(display_short)|uniprotkb:KIAA0197(gene name synonym)|uniprotkb:NUP120(gene name synonym)|uniprotkb:Nucleoporin Nup160(gene name synonym)|uniprotkb:160 kDa nucleoporin(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2511876|imex:IM-12079-19 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000172046(gene)|ensembl:ENST00000398888(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0046872"(metal ion binding)|go:"GO:0048642"(negative regulation of skeletal muscle tissue development)|go:"GO:0050821"(protein stabilization)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0090068"(positive regulation of cell cycle process)|go:"GO:1900037"(regulation of cellular response to hypoxia)|go:"GO:1901799"(negative regulation of proteasomal protein catabolic process)|go:"GO:1904292"(regulation of ERAD pathway)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR002893(Zinc finger, MYND-type)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|mint:O94966|rcsb pdb:1WH0|rcsb pdb:4X3G|rcsb pdb:6K7W|rcsb pdb:6KHV|rcsb pdb:6KQV|reactome:R-HSA-5689880|refseq:NP_001186089.1|refseq:NP_001186090.1|refseq:NP_001186091.1|refseq:NP_006668.1|refseq:XP_005264888.1|refseq:XP_016861115.1|refseq:XP_016861122.1 refseq:NP_056046.1|refseq:NP_001305328.1|dip:DIP-31262N|ensembl:ENSG00000030066(gene)|ensembl:ENST00000378460(transcript)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005643"(nuclear pore)|go:"GO:0005829"(cytosol)|go:"GO:0006406"(mRNA export from nucleus)|go:"GO:0015031"(protein transport)|go:"GO:0017056"(structural constituent of nuclear pore)|go:"GO:0031080"(nuclear pore outer ring)|go:"GO:0072006"(nephron development)|interpro:IPR021717|mint:Q12769|rcsb pdb:5A9Q|reactome:R-HSA-1169408|reactome:R-HSA-141444|reactome:R-HSA-159227|reactome:R-HSA-159230|reactome:R-HSA-159231|reactome:R-HSA-159236|reactome:R-HSA-165054|reactome:R-HSA-168271|reactome:R-HSA-168276|reactome:R-HSA-168325|reactome:R-HSA-168333|reactome:R-HSA-170822|reactome:R-HSA-180746|reactome:R-HSA-180910|reactome:R-HSA-191859|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-3108214|reactome:R-HSA-3232142|reactome:R-HSA-3301854|reactome:R-HSA-3371453|reactome:R-HSA-4085377|reactome:R-HSA-4551638|reactome:R-HSA-4570464|reactome:R-HSA-4615885|reactome:R-HSA-5578749|reactome:R-HSA-5619107|reactome:R-HSA-5663220|reactome:R-HSA-6784531|reactome:R-HSA-68877|reactome:R-HSA-9609690|reactome:R-HSA-9610379|reactome:R-HSA-9615933|reactome:R-HSA-9648025 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:5U3FuLQ44MsWtu7o/3bY7seGC3M9606 rogid:15tRpv4+wvw31oJPxM42NxWdRUc9606 intact-crc:FA7BFBBC6209D5ED|rigid:C7Rw3YMsYSriRxdgG/b9fsVZKC4 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y2K6 uniprotkb:P35249 intact:EBI-2511991|ensembl:ENSP00000313811|ensembl:ENSP00000351122|ensembl:ENSP00000361506|intact:EBI-28979612|uniprotkb:Q9UQN8|uniprotkb:Q8IXQ1|uniprotkb:Q9UQP0|uniprotkb:Q96LG5|uniprotkb:Q541F1 intact:EBI-476655|uniprotkb:Q6FHX7|ensembl:ENSP00000296273|ensembl:ENSP00000376272|uniprotkb:D3DNV2|uniprotkb:B4DM41 psi-mi:ubp20_human(display_long)|uniprotkb:USP20(gene name)|psi-mi:USP20(display_short)|uniprotkb:KIAA1003(gene name synonym)|uniprotkb:LSFR3A(gene name synonym)|uniprotkb:VDU2(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 20(gene name synonym)|uniprotkb:Deubiquitinating enzyme 20(gene name synonym)|uniprotkb:VHL-interacting deubiquitinating enzyme 2(gene name synonym)|uniprotkb:Ubiquitin thioesterase 20(gene name synonym) psi-mi:rfc4_human(display_long)|uniprotkb:Activator 1 subunit 4(gene name synonym)|uniprotkb:Replication factor C 37 kDa subunit(gene name synonym)|uniprotkb:Activator 1 37 kDa subunit(gene name synonym)|uniprotkb:RFC4(gene name)|psi-mi:RFC4(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512022|imex:IM-12079-70 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENST00000315480(transcript)|ensembl:ENST00000358355(transcript)|ensembl:ENST00000372429(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006897"(endocytosis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|ensembl:ENSG00000136878(gene)|interpro:IPR028889|interpro:IPR035927|interpro:IPR038765|mint:Q9Y2K6|rcsb pdb:6KCZ|reactome:R-HSA-5689880|refseq:XP_011516463.1|refseq:XP_011516464.1|ensembl:ENSP00000313811|ensembl:ENSP00000351122|ensembl:ENSP00000361506|refseq:NP_001008563.2|refseq:NP_001103773.2|refseq:NP_006667.3|refseq:XP_005251722.1 refseq:NP_002907.1|refseq:NP_853551.1|go:"GO:0003677"(DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|ensembl:ENSG00000163918(gene)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005663"(DNA replication factor C complex)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0006271"(DNA strand elongation involved in DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0031390"(Ctf18 RFC-like complex)|go:"GO:0031391"(Elg1 RFC-like complex)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:1900264"(positive regulation of DNA-directed DNA polymerase activity)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR008921(DNA polymerase III clamp loader subunit, C-terminal)|interpro:IPR013748(Replication factor C)|interpro:IPR027417|ensembl:ENST00000296273(transcript)|ensembl:ENST00000392481(transcript)|mint:P35249|rcsb pdb:6VVO|reactome:R-HSA-110312|reactome:R-HSA-110314|reactome:R-HSA-110320|reactome:R-HSA-174411|reactome:R-HSA-5651801|reactome:R-HSA-5655862|reactome:R-HSA-5656121|reactome:R-HSA-5656169|reactome:R-HSA-5685938|reactome:R-HSA-5685942|reactome:R-HSA-5693607|reactome:R-HSA-5693616|reactome:R-HSA-5696397|reactome:R-HSA-5696400|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6804756|reactome:R-HSA-69091|reactome:R-HSA-69473|reactome:R-HSA-176187|dip:DIP-24267N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:5uvsgAipzkqnIHoUbjFfGR9vHS09606 rogid:zn+V998ZRpYIdHmG87ExC6LFc0w9606 intact-crc:D787D8264DC9F4C7|rigid:WGC9ejC4CBnQUHLmKbKnYJSEJNo false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y2K6 uniprotkb:P35250 intact:EBI-2511991|ensembl:ENSP00000313811|ensembl:ENSP00000351122|ensembl:ENSP00000361506|intact:EBI-28979612|uniprotkb:Q9UQN8|uniprotkb:Q8IXQ1|uniprotkb:Q9UQP0|uniprotkb:Q96LG5|uniprotkb:Q541F1 intact:EBI-476409|uniprotkb:P32846|uniprotkb:Q9BU93|uniprotkb:D3DXG3|ensembl:ENSP00000055077|uniprotkb:B5BU07 psi-mi:ubp20_human(display_long)|uniprotkb:USP20(gene name)|psi-mi:USP20(display_short)|uniprotkb:KIAA1003(gene name synonym)|uniprotkb:LSFR3A(gene name synonym)|uniprotkb:VDU2(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 20(gene name synonym)|uniprotkb:Deubiquitinating enzyme 20(gene name synonym)|uniprotkb:VHL-interacting deubiquitinating enzyme 2(gene name synonym)|uniprotkb:Ubiquitin thioesterase 20(gene name synonym) psi-mi:rfc2_human(display_long)|uniprotkb:Activator 1 subunit 2(gene name synonym)|uniprotkb:Replication factor C 40 kDa subunit(gene name synonym)|uniprotkb:Activator 1 40 kDa subunit(gene name synonym)|uniprotkb:RFC2(gene name)|psi-mi:RFC2(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512022|imex:IM-12079-70 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENST00000315480(transcript)|ensembl:ENST00000358355(transcript)|ensembl:ENST00000372429(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006897"(endocytosis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|ensembl:ENSG00000136878(gene)|interpro:IPR028889|interpro:IPR035927|interpro:IPR038765|mint:Q9Y2K6|rcsb pdb:6KCZ|reactome:R-HSA-5689880|refseq:XP_011516463.1|refseq:XP_011516464.1|ensembl:ENSP00000313811|ensembl:ENSP00000351122|ensembl:ENSP00000361506|refseq:NP_001008563.2|refseq:NP_001103773.2|refseq:NP_006667.3|refseq:XP_005251722.1 ensembl:ENSG00000049541(gene)|ensembl:ENST00000055077(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005663"(DNA replication factor C complex)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0019899"(enzyme binding)|go:"GO:0031390"(Ctf18 RFC-like complex)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:1900264"(positive regulation of DNA-directed DNA polymerase activity)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR008921(DNA polymerase III clamp loader subunit, C-terminal)|interpro:IPR013748(Replication factor C)|interpro:IPR027417|mint:P35250|rcsb pdb:6VVO|reactome:R-HSA-110312|reactome:R-HSA-110314|reactome:R-HSA-110320|reactome:R-HSA-174411|reactome:R-HSA-176187|reactome:R-HSA-5651801|reactome:R-HSA-5655862|reactome:R-HSA-5656121|reactome:R-HSA-5656169|reactome:R-HSA-5685938|reactome:R-HSA-5685942|reactome:R-HSA-5693607|reactome:R-HSA-5693616|reactome:R-HSA-5696397|reactome:R-HSA-5696400|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6804756|reactome:R-HSA-69091|reactome:R-HSA-69473|refseq:NP_002905.2|refseq:NP_852136.1|refseq:NP_001265720.1|refseq:NP_001265721.1|refseq:NP_001265722.1|dip:DIP-34367N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:5uvsgAipzkqnIHoUbjFfGR9vHS09606 rogid:36ppRbKXusdkqhmmoOTQ04BWv6I9606 intact-crc:D787D8264DC9F4C7|rigid:WGC9ejC4CBnQUHLmKbKnYJSEJNo false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y2K6 uniprotkb:O00232 intact:EBI-2511991|ensembl:ENSP00000313811|ensembl:ENSP00000351122|ensembl:ENSP00000361506|intact:EBI-28979612|uniprotkb:Q9UQN8|uniprotkb:Q8IXQ1|uniprotkb:Q9UQP0|uniprotkb:Q96LG5|uniprotkb:Q541F1 intact:EBI-359733|uniprotkb:Q53HA2|uniprotkb:Q6P053|ensembl:ENSP00000348442|uniprotkb:A6NP15 psi-mi:ubp20_human(display_long)|uniprotkb:USP20(gene name)|psi-mi:USP20(display_short)|uniprotkb:KIAA1003(gene name synonym)|uniprotkb:LSFR3A(gene name synonym)|uniprotkb:VDU2(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 20(gene name synonym)|uniprotkb:Deubiquitinating enzyme 20(gene name synonym)|uniprotkb:VHL-interacting deubiquitinating enzyme 2(gene name synonym)|uniprotkb:Ubiquitin thioesterase 20(gene name synonym) psi-mi:psd12_human(display_long)|uniprotkb:PSMD12(gene name)|psi-mi:PSMD12(display_short)|uniprotkb:26S proteasome regulatory subunit p55(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN5(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512022|imex:IM-12079-70 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENST00000315480(transcript)|ensembl:ENST00000358355(transcript)|ensembl:ENST00000372429(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006897"(endocytosis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|ensembl:ENSG00000136878(gene)|interpro:IPR028889|interpro:IPR035927|interpro:IPR038765|mint:Q9Y2K6|rcsb pdb:6KCZ|reactome:R-HSA-5689880|refseq:XP_011516463.1|refseq:XP_011516464.1|ensembl:ENSP00000313811|ensembl:ENSP00000351122|ensembl:ENSP00000361506|refseq:NP_001008563.2|refseq:NP_001103773.2|refseq:NP_006667.3|refseq:XP_005251722.1 refseq:NP_002807.1|refseq:NP_001303270.1|ensembl:ENSG00000197170(gene)|ensembl:ENST00000356126(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0008541"(proteasome regulatory particle, lid subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0031595"(nuclear proteasome complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR035297|interpro:IPR036388|interpro:IPR036390|interpro:IPR040134|interpro:IPR040896|mint:O00232|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VGZ|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHS|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|rcsb pdb:5VFS|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-5687128|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|refseq:NP_777360.1|dip:DIP-27549N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:5uvsgAipzkqnIHoUbjFfGR9vHS09606 rogid:4tzcvfL/EqQRcUpoMtxVU0WC+TU9606 intact-crc:D787D8264DC9F4C7|rigid:WGC9ejC4CBnQUHLmKbKnYJSEJNo false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y2K6 uniprotkb:O15049 intact:EBI-2511991|ensembl:ENSP00000313811|ensembl:ENSP00000351122|ensembl:ENSP00000361506|intact:EBI-28979612|uniprotkb:Q9UQN8|uniprotkb:Q8IXQ1|uniprotkb:Q9UQP0|uniprotkb:Q96LG5|uniprotkb:Q541F1 intact:EBI-2512055|ensembl:ENSP00000274605|uniprotkb:Q7Z6I3|uniprotkb:B4DIL3|uniprotkb:D3DWP3|uniprotkb:Q6ZSQ6 psi-mi:ubp20_human(display_long)|uniprotkb:USP20(gene name)|psi-mi:USP20(display_short)|uniprotkb:KIAA1003(gene name synonym)|uniprotkb:LSFR3A(gene name synonym)|uniprotkb:VDU2(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 20(gene name synonym)|uniprotkb:Deubiquitinating enzyme 20(gene name synonym)|uniprotkb:VHL-interacting deubiquitinating enzyme 2(gene name synonym)|uniprotkb:Ubiquitin thioesterase 20(gene name synonym) psi-mi:n4bp3_human(display_long)|uniprotkb:N4BP3(gene name)|psi-mi:N4BP3(display_short)|uniprotkb:KIAA0341(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512022|imex:IM-12079-70 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENST00000315480(transcript)|ensembl:ENST00000358355(transcript)|ensembl:ENST00000372429(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006897"(endocytosis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|ensembl:ENSG00000136878(gene)|interpro:IPR028889|interpro:IPR035927|interpro:IPR038765|mint:Q9Y2K6|rcsb pdb:6KCZ|reactome:R-HSA-5689880|refseq:XP_011516463.1|refseq:XP_011516464.1|ensembl:ENSP00000313811|ensembl:ENSP00000351122|ensembl:ENSP00000361506|refseq:NP_001008563.2|refseq:NP_001103773.2|refseq:NP_006667.3|refseq:XP_005251722.1 ensembl:ENSG00000145911(gene)|ensembl:ENST00000274605(transcript)|go:"GO:0007399"(nervous system development)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031410"(cytoplasmic vesicle)|interpro:IPR033571|mint:O15049|refseq:XP_011532775.1|refseq:XP_011532776.1|ensembl:ENSP00000274605|refseq:NP_055926.1|refseq:XP_006714897.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:5uvsgAipzkqnIHoUbjFfGR9vHS09606 rogid:rggbUyFRXczrPNjvyOUieC/Fj0c9606 intact-crc:D787D8264DC9F4C7|rigid:WGC9ejC4CBnQUHLmKbKnYJSEJNo false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y2K6 uniprotkb:P40938 intact:EBI-2511991|ensembl:ENSP00000313811|ensembl:ENSP00000351122|ensembl:ENSP00000361506|intact:EBI-28979612|uniprotkb:Q9UQN8|uniprotkb:Q8IXQ1|uniprotkb:Q9UQP0|uniprotkb:Q96LG5|uniprotkb:Q541F1 intact:EBI-1055010|intact:EBI-2512011|uniprotkb:O15252|intact:EBI-1169853|uniprotkb:Q5W0E8|uniprotkb:C9JU95|ensembl:ENSP00000369411 psi-mi:ubp20_human(display_long)|uniprotkb:USP20(gene name)|psi-mi:USP20(display_short)|uniprotkb:KIAA1003(gene name synonym)|uniprotkb:LSFR3A(gene name synonym)|uniprotkb:VDU2(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 20(gene name synonym)|uniprotkb:Deubiquitinating enzyme 20(gene name synonym)|uniprotkb:VHL-interacting deubiquitinating enzyme 2(gene name synonym)|uniprotkb:Ubiquitin thioesterase 20(gene name synonym) psi-mi:rfc3_human(display_long)|uniprotkb:RFC3(gene name)|psi-mi:RFC3(display_short)|uniprotkb:Activator 1 subunit 3(gene name synonym)|uniprotkb:Replication factor C 38 kDa subunit(gene name synonym)|uniprotkb:Activator 1 38 kDa subunit(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512022|imex:IM-12079-70 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENST00000315480(transcript)|ensembl:ENST00000358355(transcript)|ensembl:ENST00000372429(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006897"(endocytosis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|ensembl:ENSG00000136878(gene)|interpro:IPR028889|interpro:IPR035927|interpro:IPR038765|mint:Q9Y2K6|rcsb pdb:6KCZ|reactome:R-HSA-5689880|refseq:XP_011516463.1|refseq:XP_011516464.1|ensembl:ENSP00000313811|ensembl:ENSP00000351122|ensembl:ENSP00000361506|refseq:NP_001008563.2|refseq:NP_001103773.2|refseq:NP_006667.3|refseq:XP_005251722.1 refseq:NP_002906.1|refseq:NP_853536.2|ensembl:ENSG00000133119(gene)|ensembl:ENST00000380071(transcript)|go:"GO:0000731"(DNA synthesis involved in DNA repair)|go:"GO:0003677"(DNA binding)|go:"GO:0003689"(DNA clamp loader activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005663"(DNA replication factor C complex)|go:"GO:0006260"(DNA replication)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0006271"(DNA strand elongation involved in DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0031390"(Ctf18 RFC-like complex)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0046683"(response to organophosphorus)|go:"GO:1900264"(positive regulation of DNA-directed DNA polymerase activity)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR008921(DNA polymerase III clamp loader subunit, C-terminal)|interpro:IPR027417|mint:P40938|rcsb pdb:6VVO|reactome:R-HSA-110312|reactome:R-HSA-110314|reactome:R-HSA-110320|reactome:R-HSA-174411|reactome:R-HSA-176187|reactome:R-HSA-5651801|reactome:R-HSA-5655862|reactome:R-HSA-5656121|reactome:R-HSA-5656169|reactome:R-HSA-5685938|reactome:R-HSA-5685942|reactome:R-HSA-5693607|reactome:R-HSA-5693616|reactome:R-HSA-5696397|reactome:R-HSA-5696400|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-69091|reactome:R-HSA-69473|reactome:R-HSA-6804756|dip:DIP-36432N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:5uvsgAipzkqnIHoUbjFfGR9vHS09606 rogid:XaK3OCno6yS3ubSiJhdBrW52VAw9606 intact-crc:D787D8264DC9F4C7|rigid:WGC9ejC4CBnQUHLmKbKnYJSEJNo false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y2K6 uniprotkb:O75521 intact:EBI-2511991|ensembl:ENSP00000313811|ensembl:ENSP00000351122|ensembl:ENSP00000361506|intact:EBI-28979612|uniprotkb:Q9UQN8|uniprotkb:Q8IXQ1|uniprotkb:Q9UQP0|uniprotkb:Q96LG5|uniprotkb:Q541F1 intact:EBI-2512024|ensembl:ENSP00000369461|uniprotkb:Q9NYH7|uniprotkb:Q9NQH1|uniprotkb:Q9H0T9|uniprotkb:Q5JYK7|uniprotkb:Q7L124|uniprotkb:Q9UN55|uniprotkb:Q9BUE9|uniprotkb:Q8N0X0|uniprotkb:Q5JYK5|intact:EBI-2802486 psi-mi:ubp20_human(display_long)|uniprotkb:USP20(gene name)|psi-mi:USP20(display_short)|uniprotkb:KIAA1003(gene name synonym)|uniprotkb:LSFR3A(gene name synonym)|uniprotkb:VDU2(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 20(gene name synonym)|uniprotkb:Deubiquitinating enzyme 20(gene name synonym)|uniprotkb:VHL-interacting deubiquitinating enzyme 2(gene name synonym)|uniprotkb:Ubiquitin thioesterase 20(gene name synonym) psi-mi:eci2_human(display_long)|uniprotkb:ECI2(gene name)|psi-mi:ECI2(display_short)|uniprotkb:DRS1(gene name synonym)|uniprotkb:HCA88(gene name synonym)|uniprotkb:Dodecenoyl-CoA isomerase(gene name synonym)|uniprotkb:"Delta(3),delta(2)-enoyl-CoA isomerase"(gene name synonym)|uniprotkb:Diazepam-binding inhibitor-related protein 1(gene name synonym)|uniprotkb:DRS-1(gene name synonym)|uniprotkb:Hepatocellular carcinoma-associated antigen 88(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-1(gene name synonym)|uniprotkb:PECI(gene name synonym)|uniprotkb:Peroxisomal 3,2-trans-enoyl-CoA isomerase(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512022|imex:IM-12079-70 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENST00000315480(transcript)|ensembl:ENST00000358355(transcript)|ensembl:ENST00000372429(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006897"(endocytosis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|ensembl:ENSG00000136878(gene)|interpro:IPR028889|interpro:IPR035927|interpro:IPR038765|mint:Q9Y2K6|rcsb pdb:6KCZ|reactome:R-HSA-5689880|refseq:XP_011516463.1|refseq:XP_011516464.1|ensembl:ENSP00000313811|ensembl:ENSP00000351122|ensembl:ENSP00000361506|refseq:NP_001008563.2|refseq:NP_001103773.2|refseq:NP_006667.3|refseq:XP_005251722.1 ensembl:ENSG00000198721(gene)|ensembl:ENST00000380118(transcript)|go:"GO:0000062"(fatty-acyl-CoA binding)|go:"GO:0004165"("delta(3)-delta(2)-enoyl-CoA isomerase activity")|go:"GO:0005739"(mitochondrion)|go:"GO:0005777"(peroxisome)|go:"GO:0005782"(peroxisomal matrix)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR014748(Crontonase, C-terminal)|interpro:IPR022408|interpro:IPR029045|interpro:IPR035984|mint:O75521|rcsb pdb:2CQU|rcsb pdb:2F6Q|rcsb pdb:4U18|rcsb pdb:4U19|rcsb pdb:4U1A|reactome:R-HSA-390247|reactome:R-HSA-9033241|go:"GO:0005829"(cytosol)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0009062"(fatty acid catabolic process)|go:"GO:0016020"(membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR000582(Acyl-CoA-binding protein, ACBP)|interpro:IPR001753(Crotonase, core)|refseq:NP_001159482.1|refseq:NP_006108.2|refseq:NP_996667.2 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:5uvsgAipzkqnIHoUbjFfGR9vHS09606 rogid:AIR8lybsBusmVmjgsN0Hcl6p+3g9606 intact-crc:D787D8264DC9F4C7|rigid:WGC9ejC4CBnQUHLmKbKnYJSEJNo false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y2K6 uniprotkb:Q6IQ21 intact:EBI-2511991|ensembl:ENSP00000313811|ensembl:ENSP00000351122|ensembl:ENSP00000361506|intact:EBI-28979612|uniprotkb:Q9UQN8|uniprotkb:Q8IXQ1|uniprotkb:Q9UQP0|uniprotkb:Q96LG5|uniprotkb:Q541F1 intact:EBI-2512049|ensembl:ENSP00000348673|uniprotkb:Q9NWV2|uniprotkb:Q6ZMZ6 psi-mi:ubp20_human(display_long)|uniprotkb:USP20(gene name)|psi-mi:USP20(display_short)|uniprotkb:KIAA1003(gene name synonym)|uniprotkb:LSFR3A(gene name synonym)|uniprotkb:VDU2(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 20(gene name synonym)|uniprotkb:Deubiquitinating enzyme 20(gene name synonym)|uniprotkb:VHL-interacting deubiquitinating enzyme 2(gene name synonym)|uniprotkb:Ubiquitin thioesterase 20(gene name synonym) psi-mi:zn770_human(display_long)|uniprotkb:ZNF770(gene name)|psi-mi:ZNF770(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512022|imex:IM-12079-70 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENST00000315480(transcript)|ensembl:ENST00000358355(transcript)|ensembl:ENST00000372429(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006897"(endocytosis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|ensembl:ENSG00000136878(gene)|interpro:IPR028889|interpro:IPR035927|interpro:IPR038765|mint:Q9Y2K6|rcsb pdb:6KCZ|reactome:R-HSA-5689880|refseq:XP_011516463.1|refseq:XP_011516464.1|ensembl:ENSP00000313811|ensembl:ENSP00000351122|ensembl:ENSP00000361506|refseq:NP_001008563.2|refseq:NP_001103773.2|refseq:NP_006667.3|refseq:XP_005251722.1 ensembl:ENSG00000198146(gene)|ensembl:ENST00000356321(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|reactome:R-HSA-212436|refseq:XP_011520046.1|refseq:NP_054825.2 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:5uvsgAipzkqnIHoUbjFfGR9vHS09606 rogid:xwdMLrXcDmI6wSe4l/+t4P2K3SA9606 intact-crc:D787D8264DC9F4C7|rigid:WGC9ejC4CBnQUHLmKbKnYJSEJNo false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y2K6 uniprotkb:Q9UH99 intact:EBI-2511991|ensembl:ENSP00000313811|ensembl:ENSP00000351122|ensembl:ENSP00000361506|intact:EBI-28979612|uniprotkb:Q9UQN8|uniprotkb:Q8IXQ1|uniprotkb:Q9UQP0|uniprotkb:Q96LG5|uniprotkb:Q541F1 intact:EBI-1044964|uniprotkb:O75156|uniprotkb:Q2NKN8|uniprotkb:Q6B4H1|uniprotkb:Q7Z3E3|uniprotkb:Q2T9F7|ensembl:ENSP00000383992|ensembl:ENSP00000385740|uniprotkb:B0QY62|uniprotkb:Q504T5 psi-mi:ubp20_human(display_long)|uniprotkb:USP20(gene name)|psi-mi:USP20(display_short)|uniprotkb:KIAA1003(gene name synonym)|uniprotkb:LSFR3A(gene name synonym)|uniprotkb:VDU2(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 20(gene name synonym)|uniprotkb:Deubiquitinating enzyme 20(gene name synonym)|uniprotkb:VHL-interacting deubiquitinating enzyme 2(gene name synonym)|uniprotkb:Ubiquitin thioesterase 20(gene name synonym) psi-mi:sun2_human(display_long)|uniprotkb:Sad1/unc-84 protein-like 2(gene name synonym)|uniprotkb:Rab5-interacting protein(gene name synonym)|uniprotkb:SUN2(gene name)|psi-mi:SUN2(display_short)|uniprotkb:FRIGG(gene name synonym)|uniprotkb:KIAA0668(gene name synonym)|uniprotkb:RAB5IP(gene name synonym)|uniprotkb:UNC84B(gene name synonym)|uniprotkb:Protein unc-84 homolog B(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512022|imex:IM-12079-70 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENST00000315480(transcript)|ensembl:ENST00000358355(transcript)|ensembl:ENST00000372429(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006897"(endocytosis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|ensembl:ENSG00000136878(gene)|interpro:IPR028889|interpro:IPR035927|interpro:IPR038765|mint:Q9Y2K6|rcsb pdb:6KCZ|reactome:R-HSA-5689880|refseq:XP_011516463.1|refseq:XP_011516464.1|ensembl:ENSP00000313811|ensembl:ENSP00000351122|ensembl:ENSP00000361506|refseq:NP_001008563.2|refseq:NP_001103773.2|refseq:NP_006667.3|refseq:XP_005251722.1 refseq:NP_001186508.1|refseq:NP_001186509.1|refseq:NP_056189.1|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0005521"(lamin binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005639"(integral component of nuclear inner membrane)|go:"GO:0006998"(nuclear envelope organization)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007097"(nuclear migration)|go:"GO:0008017"(microtubule binding)|go:"GO:0010008"(endosome membrane)|go:"GO:0021817"(nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031022"(nuclear migration along microfilament)|go:"GO:0031965"(nuclear membrane)|go:"GO:0034993"(meiotic nuclear membrane microtubule tethering complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0051642"(centrosome localization)|go:"GO:0090292"(nuclear matrix anchoring at nuclear membrane)|go:"GO:0140444"(cytoskeleton-nuclear membrane anchor activity)|go:"GO:0000781"(chromosome, telomeric region)|interpro:IPR012919(Sad1/UNC-like, C-terminal)|interpro:IPR030272|interpro:IPR040994|mint:Q9UH99|ensembl:ENSG00000100242(gene)|ensembl:ENST00000405510(transcript)|ensembl:ENST00000406622(transcript)|rcsb pdb:4DXS|rcsb pdb:4DXT|rcsb pdb:4FI9|rcsb pdb:6WMD|rcsb pdb:6WME|rcsb pdb:6WMF|rcsb pdb:6WMG|reactome:R-HSA-1221632|rcsb pdb:4DXR|rcsb pdb:3UNP psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:5uvsgAipzkqnIHoUbjFfGR9vHS09606 rogid:nG0s5eHv6AGh8rcdhTIJ1RdpfbU9606 intact-crc:D787D8264DC9F4C7|rigid:WGC9ejC4CBnQUHLmKbKnYJSEJNo false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y2K6 uniprotkb:Q9P0L0 intact:EBI-2511991|ensembl:ENSP00000313811|ensembl:ENSP00000351122|ensembl:ENSP00000361506|intact:EBI-28979612|uniprotkb:Q9UQN8|uniprotkb:Q8IXQ1|uniprotkb:Q9UQP0|uniprotkb:Q96LG5|uniprotkb:Q541F1 intact:EBI-1059156|uniprotkb:Q9UBZ2|uniprotkb:O75453|uniprotkb:Q5U0E7|intact:EBI-2556404|uniprotkb:A6NDZ0|intact:EBI-2512000|uniprotkb:D3DUI3|ensembl:ENSP00000382880 psi-mi:ubp20_human(display_long)|uniprotkb:USP20(gene name)|psi-mi:USP20(display_short)|uniprotkb:KIAA1003(gene name synonym)|uniprotkb:LSFR3A(gene name synonym)|uniprotkb:VDU2(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 20(gene name synonym)|uniprotkb:Deubiquitinating enzyme 20(gene name synonym)|uniprotkb:VHL-interacting deubiquitinating enzyme 2(gene name synonym)|uniprotkb:Ubiquitin thioesterase 20(gene name synonym) psi-mi:vapa_human(display_long)|uniprotkb:VAPA(gene name)|psi-mi:VAPA(display_short)|uniprotkb:VAP33(gene name synonym)|uniprotkb:33 kDa VAMP-associated protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512022|imex:IM-12079-70 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENST00000315480(transcript)|ensembl:ENST00000358355(transcript)|ensembl:ENST00000372429(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006897"(endocytosis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|ensembl:ENSG00000136878(gene)|interpro:IPR028889|interpro:IPR035927|interpro:IPR038765|mint:Q9Y2K6|rcsb pdb:6KCZ|reactome:R-HSA-5689880|refseq:XP_011516463.1|refseq:XP_011516464.1|ensembl:ENSP00000313811|ensembl:ENSP00000351122|ensembl:ENSP00000361506|refseq:NP_001008563.2|refseq:NP_001103773.2|refseq:NP_006667.3|refseq:XP_005251722.1 refseq:NP_003565.4|refseq:NP_919415.2|dip:DIP-41135N|go:"GO:0031982"(vesicle)|go:"GO:0033149"(FFAT motif binding)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0044791"(obsolete positive regulation by host of viral release from host cell)|go:"GO:0044828"(negative regulation by host of viral genome replication)|go:"GO:0044829"(positive regulation by host of viral genome replication)|go:"GO:0045296"(cadherin binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0061025"(membrane fusion)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0090114"(COPII-coated vesicle budding)|interpro:IPR000535(Major sperm protein)|interpro:IPR008962(PapD-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016763(Vesicle-associated membrane protein)|mint:Q9P0L0|rcsb pdb:2RR3|rcsb pdb:6TQR|reactome:R-HSA-1660661|reactome:R-HSA-6798695|reactome:R-HSA-9609523|ensembl:ENSG00000101558(gene)|ensembl:ENST00000400000(transcript)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031175"(neuron projection development)|go:"GO:0031965"(nuclear membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0008017"(microtubule binding)|go:"GO:0008219"(cell death)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016021"(integral component of membrane) psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:5uvsgAipzkqnIHoUbjFfGR9vHS09606 rogid:h8NG5Ak0n6b/iq2yKYMsLsJKpos9606 intact-crc:D787D8264DC9F4C7|rigid:WGC9ejC4CBnQUHLmKbKnYJSEJNo false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y2K6 uniprotkb:Q96JN8 intact:EBI-2511991|ensembl:ENSP00000313811|ensembl:ENSP00000351122|ensembl:ENSP00000361506|intact:EBI-28979612|uniprotkb:Q9UQN8|uniprotkb:Q8IXQ1|uniprotkb:Q9UQP0|uniprotkb:Q96LG5|uniprotkb:Q541F1 intact:EBI-1053406|uniprotkb:Q6GPI8|uniprotkb:Q96IU9|uniprotkb:Q9H0B0|intact:EBI-2563327|intact:EBI-28979128|ensembl:ENSP00000382390|ensembl:ENSP00000500916 psi-mi:ubp20_human(display_long)|uniprotkb:USP20(gene name)|psi-mi:USP20(display_short)|uniprotkb:KIAA1003(gene name synonym)|uniprotkb:LSFR3A(gene name synonym)|uniprotkb:VDU2(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 20(gene name synonym)|uniprotkb:Deubiquitinating enzyme 20(gene name synonym)|uniprotkb:VHL-interacting deubiquitinating enzyme 2(gene name synonym)|uniprotkb:Ubiquitin thioesterase 20(gene name synonym) psi-mi:neul4_human(display_long)|uniprotkb:NEURL4(gene name)|psi-mi:NEURL4(display_short)|uniprotkb:KIAA1787(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512022|imex:IM-12079-70 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENST00000315480(transcript)|ensembl:ENST00000358355(transcript)|ensembl:ENST00000372429(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006897"(endocytosis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|ensembl:ENSG00000136878(gene)|interpro:IPR028889|interpro:IPR035927|interpro:IPR038765|mint:Q9Y2K6|rcsb pdb:6KCZ|reactome:R-HSA-5689880|refseq:XP_011516463.1|refseq:XP_011516464.1|ensembl:ENSP00000313811|ensembl:ENSP00000351122|ensembl:ENSP00000361506|refseq:NP_001008563.2|refseq:NP_001103773.2|refseq:NP_006667.3|refseq:XP_005251722.1 refseq:NP_001005408.1|refseq:NP_115818.2|ensembl:ENST00000315614|ensembl:ENSP00000319826|ensembl:ENSP00000382390|ensembl:ENSP00000500916|ensembl:ENST00000673081|ensembl:ENSP00000500667|ensembl:ENSG00000215041(gene)|ensembl:ENSG00000288301(gene)|ensembl:ENST00000399464(transcript)|ensembl:ENST00000671847(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005814"(centriole)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR006573(NEUZ)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR037962|interpro:IPR043136|mint:Q96JN8|rcsb pdb:2E63 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:5uvsgAipzkqnIHoUbjFfGR9vHS09606 rogid:lydZRBsnJDyAdaDjTe7gJVkxL149606 intact-crc:D787D8264DC9F4C7|rigid:WGC9ejC4CBnQUHLmKbKnYJSEJNo false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y2K6 uniprotkb:P62158 intact:EBI-2511991|ensembl:ENSP00000313811|ensembl:ENSP00000351122|ensembl:ENSP00000361506|intact:EBI-28979612|uniprotkb:Q9UQN8|uniprotkb:Q8IXQ1|uniprotkb:Q9UQP0|uniprotkb:Q96LG5|uniprotkb:Q541F1 intact:EBI-397435|uniprotkb:P02593|uniprotkb:P70667|uniprotkb:P99014|uniprotkb:Q13942|uniprotkb:Q53S29|uniprotkb:Q61379|uniprotkb:Q61380|uniprotkb:Q96HK3|uniprotkb:P0DP25|uniprotkb:P0DP24|uniprotkb:P0DP23 psi-mi:ubp20_human(display_long)|uniprotkb:USP20(gene name)|psi-mi:USP20(display_short)|uniprotkb:KIAA1003(gene name synonym)|uniprotkb:LSFR3A(gene name synonym)|uniprotkb:VDU2(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 20(gene name synonym)|uniprotkb:Deubiquitinating enzyme 20(gene name synonym)|uniprotkb:VHL-interacting deubiquitinating enzyme 2(gene name synonym)|uniprotkb:Ubiquitin thioesterase 20(gene name synonym) psi-mi:calm_human(display_long)|uniprotkb:CALM1(gene name)|psi-mi:CALM1(display_short)|uniprotkb:CALM(gene name synonym)|uniprotkb:CAM(gene name synonym)|uniprotkb:CAM1(gene name synonym)|uniprotkb:CALM2(gene name)|psi-mi:CALM2(display_short)|uniprotkb:CAMB(gene name synonym)|uniprotkb:CALM3(gene name)|psi-mi:CALM3(display_short)|uniprotkb:CAM3(gene name synonym)|uniprotkb:CAMC(gene name synonym)|uniprotkb:CAMIII(gene name synonym)|uniprotkb:CAM2(gene name synonym)|uniprotkb:CALML2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512022|imex:IM-12079-70 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENST00000315480(transcript)|ensembl:ENST00000358355(transcript)|ensembl:ENST00000372429(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006897"(endocytosis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|ensembl:ENSG00000136878(gene)|interpro:IPR028889|interpro:IPR035927|interpro:IPR038765|mint:Q9Y2K6|rcsb pdb:6KCZ|reactome:R-HSA-5689880|refseq:XP_011516463.1|refseq:XP_011516464.1|ensembl:ENSP00000313811|ensembl:ENSP00000351122|ensembl:ENSP00000361506|refseq:NP_001008563.2|refseq:NP_001103773.2|refseq:NP_006667.3|refseq:XP_005251722.1 rcsb pdb:3SUI|rcsb pdb:2LGF|rcsb pdb:2LQC|rcsb pdb:2LQP|rcsb pdb:2Y4V|rcsb pdb:4JQ0|rcsb pdb:4LZX|rcsb pdb:4M1L|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|rcsb pdb:3J41|rcsb pdb:2LL6|go:"GO:0002027"(regulation of heart rate)|go:"GO:0005513"(detection of calcium ion)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0030017"(sarcomere)|go:"GO:0030801"(obsolete positive regulation of cyclic nucleotide metabolic process)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0035307"(positive regulation of protein dephosphorylation)|go:"GO:0051343"(positive regulation of cyclic-nucleotide phosphodiesterase activity)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1901844"(regulation of cell communication by electrical coupling involved in cardiac conduction)|rcsb pdb:2LV6|rcsb pdb:2N6A|refseq:NP_001734.1|refseq:NP_005175.2|refseq:NP_008819.1|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR002048(Calcium-binding EF-hand)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005876"(spindle microtubule)|go:"GO:0000922"(spindle pole)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005980"(glycogen catabolic process)|go:"GO:0006936"(muscle contraction)|go:"GO:0060315"(negative regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0002576"(platelet degranulation)|go:"GO:0060316"(positive regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0050999"(regulation of nitric-oxide synthase activity)|rcsb pdb:1AJI|rcsb pdb:1CDL|rcsb pdb:1CLL|rcsb pdb:1CTR|rcsb pdb:1IWQ|rcsb pdb:1J7O|rcsb pdb:1J7P|rcsb pdb:1K90|rcsb pdb:1K93|rcsb pdb:1L7Z|rcsb pdb:1LVC|rcsb pdb:1NKF|rcsb pdb:1PK0|rcsb pdb:1S26|rcsb pdb:1SK6|rcsb pdb:1SW8|rcsb pdb:1WRZ|rcsb pdb:1XFU|rcsb pdb:1XFV|rcsb pdb:1XFW|rcsb pdb:1XFX|rcsb pdb:1XFY|rcsb pdb:1XFZ|rcsb pdb:1Y6W|rcsb pdb:1YR5|rcsb pdb:1YRT|rcsb pdb:1YRU|rcsb pdb:1ZOT|rcsb pdb:1ZUZ|rcsb pdb:2BE6|rcsb pdb:2F3Y|rcsb pdb:2F3Z|rcsb pdb:2HF5|rcsb pdb:2I08|rcsb pdb:2JZI|rcsb pdb:2K0E|rcsb pdb:2K0F|rcsb pdb:2K0J|rcsb pdb:2K61|rcsb pdb:2KNE|rcsb pdb:2KUG|rcsb pdb:2KUH|rcsb pdb:2L53|rcsb pdb:2L7L|rcsb pdb:2R28|rcsb pdb:2V01|rcsb pdb:2V02|rcsb pdb:2VAY|rcsb pdb:2W73|rcsb pdb:2WEL|rcsb pdb:2X0G|rcsb pdb:3BYA|rcsb pdb:3DVE|rcsb pdb:3DVJ|rcsb pdb:3DVK|rcsb pdb:3DVM|rcsb pdb:3EWT|rcsb pdb:3EWV|rcsb pdb:3G43|rcsb pdb:3HR4|rcsb pdb:3O77|rcsb pdb:3O78|rcsb pdb:3OXQ|rcsb pdb:3UCT|rcsb pdb:3UCW|rcsb pdb:3UCY|rcsb pdb:4DCK|go:"GO:0010801"(negative regulation of peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031954"(positive regulation of protein autophosphorylation)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0000165"(MAPK cascade)|rcsb pdb:2M0J|rcsb pdb:2M0K|rcsb pdb:4UMO|rcsb pdb:4V0C|go:"GO:0031982"(vesicle)|rcsb pdb:4Q5U|rcsb pdb:4UPU|reactome:R-HSA-2672351|reactome:R-HSA-418359|reactome:R-HSA-425561|reactome:R-HSA-5576892|reactome:R-HSA-5578775|reactome:R-HSA-936837|refseq:NP_001292555.1|rcsb pdb:4OVN|rcsb pdb:5COC|go:"GO:0021762"(substantia nigra development)|go:"GO:0070062"(extracellular exosome)|rcsb pdb:4BW7|rcsb pdb:4BW8|rcsb pdb:4L79|rcsb pdb:5DBR|rcsb pdb:4DJC|rcsb pdb:2M55|rcsb pdb:2LL7|go:"GO:0019855"(calcium channel inhibitor activity)|go:"GO:0001975"(response to amphetamine)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030426"(growth cone)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051412"(response to corticosterone)|go:"GO:1901841"(regulation of high voltage-gated calcium channel activity)|rcsb pdb:2N77|go:"GO:0032991"(protein-containing complex)|go:"GO:0006479"(protein methylation)|go:"GO:0014069"(postsynaptic density)|rcsb pdb:5DSU|reactome:R-HSA-8876725|rcsb pdb:4GOW|rcsb pdb:4Q57|go:"GO:0043647"(inositol phosphate metabolic process)|go:"GO:0022400"(regulation of rhodopsin mediated signaling pathway)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0010880"(regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031432"(titin binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0031997"(N-terminal myristoylation domain binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0051592"(response to calcium ion)|go:"GO:0055117"(regulation of cardiac muscle contraction)|rcsb pdb:2MG5|go:"GO:0005088"|go:"GO:0007223"(Wnt signaling pathway, calcium modulating pathway)|go:"GO:0008440"(inositol-1,4,5-trisphosphate 3-kinase activity)|go:"GO:0015276"(ligand-gated ion channel activity)|go:"GO:0005634"(nucleus)|rcsb pdb:4JPZ|ensembl:ENST00000272298|ensembl:ENST00000291295|ensembl:ENST00000356978|ensembl:ENST00000596362|refseq:NP_001292553.1|refseq:NP_001292554.1|rcsb pdb:4BYF|reactome:R-HSA-111932|reactome:R-HSA-111933|reactome:R-HSA-111957|reactome:R-HSA-111997|reactome:R-HSA-114608|reactome:R-HSA-1445148|reactome:R-HSA-1474151|reactome:R-HSA-180024|reactome:R-HSA-1855204|reactome:R-HSA-203615|reactome:R-HSA-2514859|reactome:R-HSA-2871809|reactome:R-HSA-4086398|reactome:R-HSA-442717|reactome:R-HSA-442729|reactome:R-HSA-442745|reactome:R-HSA-442982|reactome:R-HSA-445355|reactome:R-HSA-451308|reactome:R-HSA-5218920|reactome:R-HSA-5218921|reactome:R-HSA-5607763|reactome:R-HSA-5626467|reactome:R-HSA-5627123|reactome:R-HSA-5673001|reactome:R-HSA-70221|reactome:R-HSA-983695|ensembl:ENSG00000143933|ensembl:ENSG00000160014|ensembl:ENSG00000198668|ensembl:ENSP00000272298|ensembl:ENSP00000291295|ensembl:ENSP00000349467|ensembl:ENSP00000472141|rcsb pdb:5NIN|rcsb pdb:5VMS|rcsb pdb:5WSU|rcsb pdb:5WSV|rcsb pdb:6U39|rcsb pdb:6U3A|rcsb pdb:6U3B|rcsb pdb:6U3D|rcsb pdb:2N8J|rcsb pdb:5GGM|rcsb pdb:5J8H|reactome:R-HSA-163615|reactome:R-HSA-5210891|refseq:NP_001316851.1|refseq:NP_001316852.1|refseq:NP_001316853.1|refseq:NP_001316854.1|refseq:NP_001316855.1|rcsb pdb:2N27|rcsb pdb:5DOW|rcsb pdb:5I0I|rcsb pdb:5J03|rcsb pdb:5K7L|rcsb pdb:5K8Q|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0043388"(positive regulation of DNA binding)|dip:DIP-31794N|rcsb pdb:1UP5|rcsb pdb:5JQA|rcsb pdb:5JTH|rcsb pdb:5OEO|rcsb pdb:5TP5|rcsb pdb:5TP6|rcsb pdb:5V02|rcsb pdb:5V03|rcsb pdb:5V7X|rcsb pdb:5WBX|rcsb pdb:5WC5|rcsb pdb:6B8L|rcsb pdb:6B8M|rcsb pdb:6B8N|rcsb pdb:6B8P|rcsb pdb:6B8Q|rcsb pdb:6C1D|rcsb pdb:6C1G|rcsb pdb:6C1H|rcsb pdb:6CNM|rcsb pdb:6CNN|rcsb pdb:6CNO|rcsb pdb:6FEG|rcsb pdb:6FEH|reactome:R-HSA-2025928|reactome:R-HSA-2151201|go:"GO:0034704"(calcium channel complex)|go:"GO:0010856"(adenylate cyclase activator activity)|go:"GO:0051186"(obsolete cofactor metabolic process)|go:"GO:0075206"(obsolete positive regulation by host of symbiont cAMP-mediated signal transduction)|go:"GO:0060314"(regulation of ryanodine-sensitive calcium-release channel activity)|interpro:IPR039030|go:"GO:1902494"(catalytic complex)|go:"GO:0043234"|go:"GO:0008179"(adenylate cyclase binding)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0030819"(obsolete positive regulation of cAMP biosynthetic process)|rcsb pdb:6BUT|rcsb pdb:6DAD|rcsb pdb:6DAE|rcsb pdb:6DAF|rcsb pdb:6DAH|rcsb pdb:6E2F|rcsb pdb:6E2G|rcsb pdb:6EEB|rcsb pdb:6GDK|rcsb pdb:6GDL|rcsb pdb:6HCS|rcsb pdb:6JI8|rcsb pdb:6JII|rcsb pdb:6JIU|rcsb pdb:6JIY|rcsb pdb:6JRS|rcsb pdb:6JV2|rcsb pdb:6K4K|rcsb pdb:6K4L|rcsb pdb:6K4R|rcsb pdb:6MUD|rcsb pdb:6MUE|rcsb pdb:6N5W|rcsb pdb:6O5G|reactome:R-HSA-438066|reactome:R-HSA-442720|reactome:R-HSA-5673000|reactome:R-HSA-6802946|reactome:R-HSA-6802949|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-9009391|reactome:R-HSA-9022535|reactome:R-HSA-9022692|reactome:R-HSA-9617324|reactome:R-HSA-9619229|reactome:R-HSA-9619483|reactome:R-HSA-9620244|go:"GO:0019722"(calcium-mediated signaling)|rcsb pdb:6PBX|rcsb pdb:6PBY|reactome:R-HSA-9649948|go:"GO:0005623"(obsolete cell)|rcsb pdb:6HR1|rcsb pdb:6OS4|rcsb pdb:6Y4P|rcsb pdb:6Y94|rcsb pdb:6Y95|reactome:R-HSA-9664323|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0016032"(viral process)|rcsb pdb:6M7H|rcsb pdb:6UZZ|rcsb pdb:6V00|rcsb pdb:6V01|rcsb pdb:6PLM|rcsb pdb:6S5T|rcsb pdb:6SZ5|rcsb pdb:6XXF|rcsb pdb:6Y4O psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:5uvsgAipzkqnIHoUbjFfGR9vHS09606 rogid:tTYcOd9bOh211njZVz7cYVybAMQ9606 intact-crc:D787D8264DC9F4C7|rigid:WGC9ejC4CBnQUHLmKbKnYJSEJNo false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y2K6 uniprotkb:Q99666 intact:EBI-2511991|ensembl:ENSP00000313811|ensembl:ENSP00000351122|ensembl:ENSP00000361506|intact:EBI-28979612|uniprotkb:Q9UQN8|uniprotkb:Q8IXQ1|uniprotkb:Q9UQP0|uniprotkb:Q96LG5|uniprotkb:Q541F1 intact:EBI-2511609|intact:EBI-28976430|ensembl:ENSP00000016946|ensembl:ENSP00000330842|uniprotkb:Q53QN2|uniprotkb:Q53T03|uniprotkb:Q59GM7|intact:EBI-2691891|intact:EBI-2555607|uniprotkb:Q9H0B2 psi-mi:ubp20_human(display_long)|uniprotkb:USP20(gene name)|psi-mi:USP20(display_short)|uniprotkb:KIAA1003(gene name synonym)|uniprotkb:LSFR3A(gene name synonym)|uniprotkb:VDU2(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 20(gene name synonym)|uniprotkb:Deubiquitinating enzyme 20(gene name synonym)|uniprotkb:VHL-interacting deubiquitinating enzyme 2(gene name synonym)|uniprotkb:Ubiquitin thioesterase 20(gene name synonym) psi-mi:rgpd5_human(display_long)|uniprotkb:RGP5(gene name synonym)|uniprotkb:RGPD7(gene name synonym)|uniprotkb:RANBP2L2(gene name synonym)|uniprotkb:RGP6(gene name synonym)|uniprotkb:Ran-binding protein 2-like 1/2(gene name synonym)|uniprotkb:Sperm membrane protein BS-63(gene name synonym)|uniprotkb:RGPD5(gene name)|psi-mi:RGPD5(display_short)|uniprotkb:RGP7(gene name synonym)|uniprotkb:RGPD6(gene name)|psi-mi:RGPD6(display_short)|uniprotkb:RANBP2L1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512022|imex:IM-12079-70 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENST00000315480(transcript)|ensembl:ENST00000358355(transcript)|ensembl:ENST00000372429(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006897"(endocytosis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|ensembl:ENSG00000136878(gene)|interpro:IPR028889|interpro:IPR035927|interpro:IPR038765|mint:Q9Y2K6|rcsb pdb:6KCZ|reactome:R-HSA-5689880|refseq:XP_011516463.1|refseq:XP_011516464.1|ensembl:ENSP00000313811|ensembl:ENSP00000351122|ensembl:ENSP00000361506|refseq:NP_001008563.2|refseq:NP_001103773.2|refseq:NP_006667.3|refseq:XP_005251722.1 ensembl:ENSG00000015568(gene)|ensembl:ENSG00000183054(gene)|ensembl:ENST00000016946(transcript)|go:"GO:0005643"(nuclear pore)|go:"GO:0005737"(cytoplasm)|go:"GO:0006607"(NLS-bearing protein import into nucleus)|ensembl:ENST00000329516(transcript)|go:"GO:0050790"(regulation of catalytic activity)|interpro:IPR000156(Ran Binding Protein 1)|interpro:IPR000237(GRIP)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR019734|interpro:IPR032023|refseq:NP_001032955.1|refseq:NP_001116835.1|refseq:NP_005045.2|refseq:NP_115636.1|ensembl:ENSP00000016946|ensembl:ENST00000272454|ensembl:ENSP00000272454|ensembl:ENSP00000330842|ensembl:ENST00000330331|ensembl:ENSP00000330023|ensembl:ENST00000393283|ensembl:ENSP00000376962 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:5uvsgAipzkqnIHoUbjFfGR9vHS09606 rogid:3VCS4B+diYoEK+/iXK6YN6Xp+2A9606 intact-crc:D787D8264DC9F4C7|rigid:WGC9ejC4CBnQUHLmKbKnYJSEJNo false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y2K6 uniprotkb:P60228 intact:EBI-2511991|ensembl:ENSP00000313811|ensembl:ENSP00000351122|ensembl:ENSP00000361506|intact:EBI-28979612|uniprotkb:Q9UQN8|uniprotkb:Q8IXQ1|uniprotkb:Q9UQP0|uniprotkb:Q96LG5|uniprotkb:Q541F1 intact:EBI-347740|uniprotkb:O43902|uniprotkb:Q64058|uniprotkb:Q64059|uniprotkb:Q64252|uniprotkb:Q8WVK4|intact:EBI-1237448|uniprotkb:Q6FG33|ensembl:ENSP00000220849 psi-mi:ubp20_human(display_long)|uniprotkb:USP20(gene name)|psi-mi:USP20(display_short)|uniprotkb:KIAA1003(gene name synonym)|uniprotkb:LSFR3A(gene name synonym)|uniprotkb:VDU2(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 20(gene name synonym)|uniprotkb:Deubiquitinating enzyme 20(gene name synonym)|uniprotkb:VHL-interacting deubiquitinating enzyme 2(gene name synonym)|uniprotkb:Ubiquitin thioesterase 20(gene name synonym) psi-mi:eif3e_human(display_long)|uniprotkb:EIF3E(gene name)|psi-mi:EIF3E(display_short)|uniprotkb:INT6(gene name synonym)|uniprotkb:EIF3S6(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 6(gene name synonym)|uniprotkb:eIF-3 p48(gene name synonym)|uniprotkb:Viral integration site protein INT-6 homolog(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512022|imex:IM-12079-70 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENST00000315480(transcript)|ensembl:ENST00000358355(transcript)|ensembl:ENST00000372429(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006897"(endocytosis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|ensembl:ENSG00000136878(gene)|interpro:IPR028889|interpro:IPR035927|interpro:IPR038765|mint:Q9Y2K6|rcsb pdb:6KCZ|reactome:R-HSA-5689880|refseq:XP_011516463.1|refseq:XP_011516464.1|ensembl:ENSP00000313811|ensembl:ENSP00000351122|ensembl:ENSP00000361506|refseq:NP_001008563.2|refseq:NP_001103773.2|refseq:NP_006667.3|refseq:XP_005251722.1 refseq:NP_001559.1|ensembl:ENSG00000104408(gene)|ensembl:ENST00000220849(transcript)|dip:DIP-32691N|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0016020"(membrane)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0016605"(PML body)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0045296"(cadherin binding)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071540"(eukaryotic translation initiation factor 3 complex, eIF3e)|go:"GO:1902416"(positive regulation of mRNA binding)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR016650(Translation initiation factor 3, subunit 6, eukaryotic)|interpro:IPR019010|interpro:IPR036390|mint:P60228|rcsb pdb:3J8B|rcsb pdb:3J8C|rcsb pdb:6FEC|rcsb pdb:6YBD|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:5uvsgAipzkqnIHoUbjFfGR9vHS09606 rogid:s09LicCa0mb9WwO7esZvVdvUonY9606 intact-crc:D787D8264DC9F4C7|rigid:WGC9ejC4CBnQUHLmKbKnYJSEJNo false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y2K6 intact:EBI-2509404 intact:EBI-2511991|ensembl:ENSP00000313811|ensembl:ENSP00000351122|ensembl:ENSP00000361506|intact:EBI-28979612|uniprotkb:Q9UQN8|uniprotkb:Q8IXQ1|uniprotkb:Q9UQP0|uniprotkb:Q96LG5|uniprotkb:Q541F1 uniparc:UPI0000492F36 psi-mi:ubp20_human(display_long)|uniprotkb:USP20(gene name)|psi-mi:USP20(display_short)|uniprotkb:KIAA1003(gene name synonym)|uniprotkb:LSFR3A(gene name synonym)|uniprotkb:VDU2(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 20(gene name synonym)|uniprotkb:Deubiquitinating enzyme 20(gene name synonym)|uniprotkb:VHL-interacting deubiquitinating enzyme 2(gene name synonym)|uniprotkb:Ubiquitin thioesterase 20(gene name synonym) psi-mi:ipi00456880(display_short)|psi-mi:EBI-2509404(display_long) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512022|imex:IM-12079-70 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENST00000315480(transcript)|ensembl:ENST00000358355(transcript)|ensembl:ENST00000372429(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006897"(endocytosis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|ensembl:ENSG00000136878(gene)|interpro:IPR028889|interpro:IPR035927|interpro:IPR038765|mint:Q9Y2K6|rcsb pdb:6KCZ|reactome:R-HSA-5689880|refseq:XP_011516463.1|refseq:XP_011516464.1|ensembl:ENSP00000313811|ensembl:ENSP00000351122|ensembl:ENSP00000361506|refseq:NP_001008563.2|refseq:NP_001103773.2|refseq:NP_006667.3|refseq:XP_005251722.1 - psi-mi:"MI:0469"(intact) - no-uniprot-update:An amino acid sequence which is not represented in UniProt figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:5uvsgAipzkqnIHoUbjFfGR9vHS09606 rogid:DdjTKfXNulubmAhT7N4iaoef6mI9606 intact-crc:D787D8264DC9F4C7|rigid:WGC9ejC4CBnQUHLmKbKnYJSEJNo false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y2K6 uniprotkb:P22830 intact:EBI-2511991|ensembl:ENSP00000313811|ensembl:ENSP00000351122|ensembl:ENSP00000361506|intact:EBI-28979612|uniprotkb:Q9UQN8|uniprotkb:Q8IXQ1|uniprotkb:Q9UQP0|uniprotkb:Q96LG5|uniprotkb:Q541F1 intact:EBI-1390356|uniprotkb:Q8IXN1|uniprotkb:Q8NAN0|uniprotkb:A8KA72|ensembl:ENSP00000262093 psi-mi:ubp20_human(display_long)|uniprotkb:USP20(gene name)|psi-mi:USP20(display_short)|uniprotkb:KIAA1003(gene name synonym)|uniprotkb:LSFR3A(gene name synonym)|uniprotkb:VDU2(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 20(gene name synonym)|uniprotkb:Deubiquitinating enzyme 20(gene name synonym)|uniprotkb:VHL-interacting deubiquitinating enzyme 2(gene name synonym)|uniprotkb:Ubiquitin thioesterase 20(gene name synonym) psi-mi:hemh_human(display_long)|uniprotkb:Protoheme ferro-lyase(gene name synonym)|uniprotkb:Heme synthase(gene name synonym)|uniprotkb:FECH(gene name)|psi-mi:FECH(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512022|imex:IM-12079-70 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENST00000315480(transcript)|ensembl:ENST00000358355(transcript)|ensembl:ENST00000372429(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006897"(endocytosis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|ensembl:ENSG00000136878(gene)|interpro:IPR028889|interpro:IPR035927|interpro:IPR038765|mint:Q9Y2K6|rcsb pdb:6KCZ|reactome:R-HSA-5689880|refseq:XP_011516463.1|refseq:XP_011516464.1|ensembl:ENSP00000313811|ensembl:ENSP00000351122|ensembl:ENSP00000361506|refseq:NP_001008563.2|refseq:NP_001103773.2|refseq:NP_006667.3|refseq:XP_005251722.1 refseq:NP_000131.2|refseq:NP_001012533.1|dip:DIP-39632N|ensembl:ENSG00000066926(gene)|ensembl:ENST00000262093(transcript)|go:"GO:0004325"(ferrochelatase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0009416"(response to light stimulus)|go:"GO:0010288"(response to lead ion)|go:"GO:0017085"(response to insecticide)|go:"GO:0042493"|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045471"(response to ethanol)|go:"GO:0046501"(protoporphyrinogen IX metabolic process)|go:"GO:0046685"(response to arsenic-containing substance)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051597"(response to methylmercury)|go:"GO:0070541"(response to platinum ion)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|interpro:IPR001015(Ferrochelatase)|interpro:IPR019772|interpro:IPR033644|interpro:IPR033659|rcsb pdb:1HRK|rcsb pdb:2HRC|rcsb pdb:2HRE|rcsb pdb:2PNJ|rcsb pdb:2PO5|rcsb pdb:2PO7|rcsb pdb:2QD1|rcsb pdb:2QD2|rcsb pdb:2QD3|rcsb pdb:2QD4|rcsb pdb:2QD5|rcsb pdb:3AQI|rcsb pdb:3HCN|rcsb pdb:3HCO|rcsb pdb:3HCP|rcsb pdb:3HCR|rcsb pdb:3W1W|rcsb pdb:4F4D|rcsb pdb:4KLA|rcsb pdb:4KLC|rcsb pdb:4KLR|rcsb pdb:4KMM|rcsb pdb:4MK4|reactome:R-HSA-189451 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:5uvsgAipzkqnIHoUbjFfGR9vHS09606 rogid:Rh4ulxUAnCedNUVAABAhY4iOnuo9606 intact-crc:D787D8264DC9F4C7|rigid:WGC9ejC4CBnQUHLmKbKnYJSEJNo false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y2K6 uniprotkb:Q5T9A4 intact:EBI-2511991|ensembl:ENSP00000313811|ensembl:ENSP00000351122|ensembl:ENSP00000361506|intact:EBI-28979612|uniprotkb:Q9UQN8|uniprotkb:Q8IXQ1|uniprotkb:Q9UQP0|uniprotkb:Q96LG5|uniprotkb:Q541F1 intact:EBI-1384144|uniprotkb:Q6ZRB5|uniprotkb:Q9BUK4|uniprotkb:Q9ULE7|uniprotkb:A8K3H1|ensembl:ENSP00000500094 psi-mi:ubp20_human(display_long)|uniprotkb:USP20(gene name)|psi-mi:USP20(display_short)|uniprotkb:KIAA1003(gene name synonym)|uniprotkb:LSFR3A(gene name synonym)|uniprotkb:VDU2(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 20(gene name synonym)|uniprotkb:Deubiquitinating enzyme 20(gene name synonym)|uniprotkb:VHL-interacting deubiquitinating enzyme 2(gene name synonym)|uniprotkb:Ubiquitin thioesterase 20(gene name synonym) psi-mi:atd3b_human(display_long)|uniprotkb:TOB3(gene name synonym)|uniprotkb:AAA-TOB3(gene name synonym)|uniprotkb:KIAA1273(gene name synonym)|uniprotkb:ATAD3B(gene name)|psi-mi:ATAD3B(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512022|imex:IM-12079-70 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENST00000315480(transcript)|ensembl:ENST00000358355(transcript)|ensembl:ENST00000372429(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006897"(endocytosis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|ensembl:ENSG00000136878(gene)|interpro:IPR028889|interpro:IPR035927|interpro:IPR038765|mint:Q9Y2K6|rcsb pdb:6KCZ|reactome:R-HSA-5689880|refseq:XP_011516463.1|refseq:XP_011516464.1|ensembl:ENSP00000313811|ensembl:ENSP00000351122|ensembl:ENSP00000361506|refseq:NP_001008563.2|refseq:NP_001103773.2|refseq:NP_006667.3|refseq:XP_005251722.1 refseq:NP_114127.3|refseq:NP_001304167.1|ensembl:ENSG00000160072(gene)|ensembl:ENST00000673477(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0101003"(ficolin-1-rich granule membrane)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR021911|interpro:IPR027417|interpro:IPR039188|mint:Q5T9A4|reactome:R-HSA-6798695 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:5uvsgAipzkqnIHoUbjFfGR9vHS09606 rogid:2W52iPQhTBU2apShm8xhfenV1mU9606 intact-crc:D787D8264DC9F4C7|rigid:WGC9ejC4CBnQUHLmKbKnYJSEJNo false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y2K6 uniprotkb:Q68DG8 intact:EBI-2511991|ensembl:ENSP00000313811|ensembl:ENSP00000351122|ensembl:ENSP00000361506|intact:EBI-28979612|uniprotkb:Q9UQN8|uniprotkb:Q8IXQ1|uniprotkb:Q9UQP0|uniprotkb:Q96LG5|uniprotkb:Q541F1 intact:EBI-2512007|uniprotkb:C9JKH8 psi-mi:ubp20_human(display_long)|uniprotkb:USP20(gene name)|psi-mi:USP20(display_short)|uniprotkb:KIAA1003(gene name synonym)|uniprotkb:LSFR3A(gene name synonym)|uniprotkb:VDU2(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 20(gene name synonym)|uniprotkb:Deubiquitinating enzyme 20(gene name synonym)|uniprotkb:VHL-interacting deubiquitinating enzyme 2(gene name synonym)|uniprotkb:Ubiquitin thioesterase 20(gene name synonym) psi-mi:q68dg8_human(display_long)|uniprotkb:DKFZp781N1423(gene name)|psi-mi:DKFZp781N1423(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512022|imex:IM-12079-70 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENST00000315480(transcript)|ensembl:ENST00000358355(transcript)|ensembl:ENST00000372429(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006897"(endocytosis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|ensembl:ENSG00000136878(gene)|interpro:IPR028889|interpro:IPR035927|interpro:IPR038765|mint:Q9Y2K6|rcsb pdb:6KCZ|reactome:R-HSA-5689880|refseq:XP_011516463.1|refseq:XP_011516464.1|ensembl:ENSP00000313811|ensembl:ENSP00000351122|ensembl:ENSP00000361506|refseq:NP_001008563.2|refseq:NP_001103773.2|refseq:NP_006667.3|refseq:XP_005251722.1 - psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:5uvsgAipzkqnIHoUbjFfGR9vHS09606 rogid:urqdEo4YqYbX4Y659//8RQkU7pA9606 intact-crc:D787D8264DC9F4C7|rigid:WGC9ejC4CBnQUHLmKbKnYJSEJNo false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y2K6 uniprotkb:Q15008 intact:EBI-2511991|ensembl:ENSP00000313811|ensembl:ENSP00000351122|ensembl:ENSP00000361506|intact:EBI-28979612|uniprotkb:Q9UQN8|uniprotkb:Q8IXQ1|uniprotkb:Q9UQP0|uniprotkb:Q96LG5|uniprotkb:Q541F1 intact:EBI-359701|uniprotkb:E9PHI9|uniprotkb:A8K2E0|ensembl:ENSP00000295901|uniprotkb:Q6UV22 psi-mi:ubp20_human(display_long)|uniprotkb:USP20(gene name)|psi-mi:USP20(display_short)|uniprotkb:KIAA1003(gene name synonym)|uniprotkb:LSFR3A(gene name synonym)|uniprotkb:VDU2(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 20(gene name synonym)|uniprotkb:Deubiquitinating enzyme 20(gene name synonym)|uniprotkb:VHL-interacting deubiquitinating enzyme 2(gene name synonym)|uniprotkb:Ubiquitin thioesterase 20(gene name synonym) psi-mi:psmd6_human(display_long)|uniprotkb:PSMD6(gene name)|psi-mi:PSMD6(display_short)|uniprotkb:KIAA0107(gene name synonym)|uniprotkb:PFAAP4(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S10(gene name synonym)|uniprotkb:p42A(gene name synonym)|uniprotkb:Proteasome regulatory particle subunit p44S10(gene name synonym)|uniprotkb:Phosphonoformate immuno-associated protein 4(gene name synonym)|uniprotkb:Breast cancer-associated protein SGA-113M(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN7(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512022|imex:IM-12079-70 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENST00000315480(transcript)|ensembl:ENST00000358355(transcript)|ensembl:ENST00000372429(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006897"(endocytosis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|ensembl:ENSG00000136878(gene)|interpro:IPR028889|interpro:IPR035927|interpro:IPR038765|mint:Q9Y2K6|rcsb pdb:6KCZ|reactome:R-HSA-5689880|refseq:XP_011516463.1|refseq:XP_011516464.1|ensembl:ENSP00000313811|ensembl:ENSP00000351122|ensembl:ENSP00000361506|refseq:NP_001008563.2|refseq:NP_001103773.2|refseq:NP_006667.3|refseq:XP_005251722.1 refseq:NP_055629.1|ensembl:ENSG00000163636(gene)|ensembl:ENST00000295901(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019585|interpro:IPR035268|interpro:IPR036390|mint:Q15008|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VGZ|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHS|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSG|rcsb pdb:6MSH|reactome:R-HSA-5358346|reactome:R-HSA-1236978|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-1236974|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|reactome:R-HSA-69601|reactome:R-HSA-69481|refseq:NP_001258708.1|refseq:NP_001258709.1|refseq:NP_001258710.1|dip:DIP-27590N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:5uvsgAipzkqnIHoUbjFfGR9vHS09606 rogid:ULOM02v6J56vZLlAGn7wN3N6Efw9606 intact-crc:D787D8264DC9F4C7|rigid:WGC9ejC4CBnQUHLmKbKnYJSEJNo false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y2K6 uniprotkb:Q15149 intact:EBI-2511991|ensembl:ENSP00000313811|ensembl:ENSP00000351122|ensembl:ENSP00000361506|intact:EBI-28979612|uniprotkb:Q9UQN8|uniprotkb:Q8IXQ1|uniprotkb:Q9UQP0|uniprotkb:Q96LG5|uniprotkb:Q541F1 intact:EBI-297903|intact:EBI-1103289|intact:EBI-1103265|intact:EBI-1055056|uniprotkb:Q15148|uniprotkb:Q16640|ensembl:ENSP00000323856|uniprotkb:Q6S376|intact:EBI-28976159|uniprotkb:Q6S380|intact:EBI-1103313|uniprotkb:Q6S377|uniprotkb:Q6S378|uniprotkb:Q6S379|intact:EBI-1103301|intact:EBI-1103253|uniprotkb:Q6S381|uniprotkb:Q6S382|uniprotkb:Q6S383|intact:EBI-2825763 psi-mi:ubp20_human(display_long)|uniprotkb:USP20(gene name)|psi-mi:USP20(display_short)|uniprotkb:KIAA1003(gene name synonym)|uniprotkb:LSFR3A(gene name synonym)|uniprotkb:VDU2(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 20(gene name synonym)|uniprotkb:Deubiquitinating enzyme 20(gene name synonym)|uniprotkb:VHL-interacting deubiquitinating enzyme 2(gene name synonym)|uniprotkb:Ubiquitin thioesterase 20(gene name synonym) psi-mi:plec_human(display_long)|uniprotkb:PLEC(gene name)|psi-mi:PLEC(display_short)|uniprotkb:Hemidesmosomal protein 1(gene name synonym)|uniprotkb:PLEC1(gene name synonym)|uniprotkb:Plectin-1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512022|imex:IM-12079-70 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENST00000315480(transcript)|ensembl:ENST00000358355(transcript)|ensembl:ENST00000372429(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006897"(endocytosis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|ensembl:ENSG00000136878(gene)|interpro:IPR028889|interpro:IPR035927|interpro:IPR038765|mint:Q9Y2K6|rcsb pdb:6KCZ|reactome:R-HSA-5689880|refseq:XP_011516463.1|refseq:XP_011516464.1|ensembl:ENSP00000313811|ensembl:ENSP00000351122|ensembl:ENSP00000361506|refseq:NP_001008563.2|refseq:NP_001103773.2|refseq:NP_006667.3|refseq:XP_005251722.1 go:"GO:0030018"(Z disc)|go:"GO:0030056"(hemidesmosome)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031581"(hemidesmosome assembly)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0032094"(response to food)|go:"GO:0032287"(peripheral nervous system myelin maintenance)|go:"GO:0034332"(adherens junction organization)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0042060"(wound healing)|go:"GO:0042383"(sarcolemma)|go:"GO:0043034"(costamere)|go:"GO:0043114"(regulation of vascular permeability)|go:"GO:0043209"(myelin sheath)|go:"GO:0043621"(protein self-association)|go:"GO:0043933"(protein-containing complex organization)|go:"GO:0045104"(intermediate filament cytoskeleton organization)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0045214"(sarcomere organization)|go:"GO:0045296"(cadherin binding)|go:"GO:0045445"(myoblast differentiation)|go:"GO:0048471"(perinuclear region of cytoplasm)|ensembl:ENSG00000178209(gene)|ensembl:ENST00000322810(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0002162"(dystroglycan binding)|go:"GO:0002522"(leukocyte migration involved in immune response)|go:"GO:0003334"(keratinocyte development)|go:"GO:0003723"(RNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005737"(cytoplasm)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0061436"(establishment of skin barrier)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070584"(mitochondrion morphogenesis)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071464"(cellular response to hydrostatic pressure)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0120193"(tight junction organization)|go:"GO:2000689"(actomyosin contractile ring assembly actin filament organization)|go:"GO:2000983"(regulation of ATP citrate synthase activity)|interpro:IPR001101(Plectin repeat)|interpro:IPR001452(Src homology-3)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR005326(Plectin/S10, N-terminal)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005925"(focal adhesion)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006997"(nucleus organization)|go:"GO:0008307"(structural constituent of muscle)|go:"GO:0010467"(gene expression)|go:"GO:0010761"(fibroblast migration)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0014866"(skeletal myofibril assembly)|go:"GO:0016020"(membrane)|go:"GO:0016528"(sarcoplasm)|go:"GO:0016569"(obsolete covalent chromatin modification)|go:"GO:0019226"(transmission of nerve impulse)|interpro:IPR030269|interpro:IPR035915|interpro:IPR018159|interpro:IPR036388|interpro:IPR036872|interpro:IPR041573|interpro:IPR041615|interpro:IPR043197|mint:Q15149|rcsb pdb:1MB8|rcsb pdb:2N03|rcsb pdb:2ODU|rcsb pdb:2ODV|rcsb pdb:3F7P|rcsb pdb:3PDY|rcsb pdb:3PE0|rcsb pdb:4GDO|rcsb pdb:4Q58|rcsb pdb:4Q59|rcsb pdb:5J1F|rcsb pdb:5J1G|rcsb pdb:5J1H|rcsb pdb:5J1I|reactome:R-HSA-2022090|reactome:R-HSA-264870|reactome:R-HSA-446107|ensembl:ENST00000436759|ensembl:ENSP00000388180|ensembl:ENST00000527096|ensembl:ENSP00000434583|ensembl:ENSP00000323856|ensembl:ENST00000345136|ensembl:ENSP00000344848|ensembl:ENST00000354589|ensembl:ENSP00000346602|ensembl:ENST00000354958|ensembl:ENSP00000347044|ensembl:ENST00000356346|ensembl:ENSP00000348702|ensembl:ENST00000357649|ensembl:ENSP00000350277|ensembl:ENST00000398774|ensembl:ENSP00000381756|refseq:NP_000436.2|refseq:NP_958780.1|refseq:NP_958781.1|refseq:NP_958782.1|refseq:NP_958783.1|refseq:NP_958784.1|refseq:NP_958785.1|refseq:NP_958786.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:5uvsgAipzkqnIHoUbjFfGR9vHS09606 rogid:zbctDAOOCaJUx3WBdp85v7SI0sI9606 intact-crc:D787D8264DC9F4C7|rigid:WGC9ejC4CBnQUHLmKbKnYJSEJNo false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y2K6 uniprotkb:Q96C24 intact:EBI-2511991|ensembl:ENSP00000313811|ensembl:ENSP00000351122|ensembl:ENSP00000361506|intact:EBI-28979612|uniprotkb:Q9UQN8|uniprotkb:Q8IXQ1|uniprotkb:Q9UQP0|uniprotkb:Q96LG5|uniprotkb:Q541F1 intact:EBI-747142|uniprotkb:Q5H9J3|uniprotkb:Q5JPG8|uniprotkb:Q8N9P4|uniprotkb:Q9H4R0|uniprotkb:Q9H4R1|ensembl:ENSP00000263033|ensembl:ENSP00000276141|ensembl:ENSP00000362080 psi-mi:ubp20_human(display_long)|uniprotkb:USP20(gene name)|psi-mi:USP20(display_short)|uniprotkb:KIAA1003(gene name synonym)|uniprotkb:LSFR3A(gene name synonym)|uniprotkb:VDU2(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 20(gene name synonym)|uniprotkb:Deubiquitinating enzyme 20(gene name synonym)|uniprotkb:VHL-interacting deubiquitinating enzyme 2(gene name synonym)|uniprotkb:Ubiquitin thioesterase 20(gene name synonym) psi-mi:sytl4_human(display_long)|uniprotkb:Exophilin-2(gene name synonym)|uniprotkb:Granuphilin(gene name synonym)|uniprotkb:SYTL4(gene name)|psi-mi:SYTL4(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512022|imex:IM-12079-70 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENST00000315480(transcript)|ensembl:ENST00000358355(transcript)|ensembl:ENST00000372429(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006897"(endocytosis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|ensembl:ENSG00000136878(gene)|interpro:IPR028889|interpro:IPR035927|interpro:IPR038765|mint:Q9Y2K6|rcsb pdb:6KCZ|reactome:R-HSA-5689880|refseq:XP_011516463.1|refseq:XP_011516464.1|ensembl:ENSP00000313811|ensembl:ENSP00000351122|ensembl:ENSP00000361506|refseq:NP_001008563.2|refseq:NP_001103773.2|refseq:NP_006667.3|refseq:XP_005251722.1 refseq:NP_001123368.1|refseq:NP_001167539.1|refseq:NP_542775.2|refseq:XP_011529370.1|ensembl:ENSP00000263033|ensembl:ENSP00000276141|ensembl:ENST00000372981|ensembl:ENSP00000362072|ensembl:ENSP00000362080|refseq:XP_005262286.1|go:"GO:0032418"(lysosome localization)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046872"(metal ion binding)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0070382"(exocytic vesicle)|go:"GO:0071985"(multivesicular body sorting pathway)|go:"GO:1905684"(regulation of plasma membrane repair)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001565(Synaptotagmin)|interpro:IPR010911(Rab-binding)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR028694|interpro:IPR035892|interpro:IPR037303|interpro:IPR041282|interpro:IPR043567|interpro:IPR044134|rcsb pdb:2CSZ|rcsb pdb:3FDW|rcsb pdb:5X6T|reactome:R-HSA-114608|go:"GO:0031267"(small GTPase binding)|ensembl:ENSG00000102362(gene)|ensembl:ENST00000263033(transcript)|ensembl:ENST00000276141(transcript)|ensembl:ENST00000372989(transcript)|go:"GO:0001778"(plasma membrane repair)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006887"(exocytosis)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0031092"(platelet alpha granule membrane)|refseq:XP_016885460.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:5uvsgAipzkqnIHoUbjFfGR9vHS09606 rogid:mL6mjIGzdpbem45EAZ6WE8I5nsE9606 intact-crc:D787D8264DC9F4C7|rigid:WGC9ejC4CBnQUHLmKbKnYJSEJNo false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y2K6 uniprotkb:P53350 intact:EBI-2511991|ensembl:ENSP00000313811|ensembl:ENSP00000351122|ensembl:ENSP00000361506|intact:EBI-28979612|uniprotkb:Q9UQN8|uniprotkb:Q8IXQ1|uniprotkb:Q9UQP0|uniprotkb:Q96LG5|uniprotkb:Q541F1 intact:EBI-476768|uniprotkb:Q15153|uniprotkb:Q99746|ensembl:ENSP00000300093 psi-mi:ubp20_human(display_long)|uniprotkb:USP20(gene name)|psi-mi:USP20(display_short)|uniprotkb:KIAA1003(gene name synonym)|uniprotkb:LSFR3A(gene name synonym)|uniprotkb:VDU2(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 20(gene name synonym)|uniprotkb:Deubiquitinating enzyme 20(gene name synonym)|uniprotkb:VHL-interacting deubiquitinating enzyme 2(gene name synonym)|uniprotkb:Ubiquitin thioesterase 20(gene name synonym) psi-mi:plk1_human(display_long)|uniprotkb:Polo-like kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 13(gene name synonym)|uniprotkb:PLK1(gene name)|psi-mi:PLK1(display_short)|uniprotkb:PLK(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512022|imex:IM-12079-70 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENST00000315480(transcript)|ensembl:ENST00000358355(transcript)|ensembl:ENST00000372429(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006897"(endocytosis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|ensembl:ENSG00000136878(gene)|interpro:IPR028889|interpro:IPR035927|interpro:IPR038765|mint:Q9Y2K6|rcsb pdb:6KCZ|reactome:R-HSA-5689880|refseq:XP_011516463.1|refseq:XP_011516464.1|ensembl:ENSP00000313811|ensembl:ENSP00000351122|ensembl:ENSP00000361506|refseq:NP_001008563.2|refseq:NP_001103773.2|refseq:NP_006667.3|refseq:XP_005251722.1 refseq:NP_005021.2|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0034451"(centriolar satellite)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0045143"(homologous chromosome segregation)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0051081"(nuclear membrane disassembly)|go:"GO:0051233"(spindle midzone)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070194"(synaptonemal complex disassembly)|go:"GO:0071168"(protein localization to chromatin)|go:"GO:0090435"(protein localization to nuclear envelope)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901673"(regulation of mitotic spindle assembly)|go:"GO:1901990"(regulation of mitotic cell cycle phase transition)|ensembl:ENSG00000166851(gene)|ensembl:ENST00000300093(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000776"(kinetochore)|go:"GO:0000785"(chromatin)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0000922"(spindle pole)|go:"GO:0000940"(outer kinetochore)|go:"GO:0001578"(microtubule bundle formation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0007076"(mitotic chromosome condensation)|go:"GO:0007077"(mitotic nuclear membrane disassembly)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0005524"(ATP binding)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0008017"(microtubule binding)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0010997"(anaphase-promoting complex binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016321"(female meiosis chromosome segregation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030071"(regulation of mitotic metaphase/anaphase transition)|go:"GO:0030496"(midbody)|go:"GO:0031648"(protein destabilization)|rcsb pdb:4DFW|rcsb pdb:4E67|rcsb pdb:4E9C|rcsb pdb:4E9D|rcsb pdb:4H5X|rcsb pdb:4H71|rcsb pdb:4HAB|rcsb pdb:4HCO|rcsb pdb:4HY2|rcsb pdb:4J52|rcsb pdb:4J53|rcsb pdb:4LKL|rcsb pdb:4LKM|rcsb pdb:4O56|rcsb pdb:4O6W|rcsb pdb:4O9W|rcsb pdb:4RCP|rcsb pdb:4WHH|rcsb pdb:4WHK|rcsb pdb:4WHL|rcsb pdb:4X9R|rcsb pdb:4X9V|rcsb pdb:4X9W|rcsb pdb:5J19|rcsb pdb:5NEI|rcsb pdb:5NFU|rcsb pdb:5NJE|rcsb pdb:5NMM|rcsb pdb:5NN1|rcsb pdb:5NN2|rcsb pdb:5TA6|rcsb pdb:5TA8|rcsb pdb:6AX4|rcsb pdb:6GY2|reactome:R-HSA-141444|reactome:R-HSA-156711|reactome:R-HSA-162658|reactome:R-HSA-174178|reactome:R-HSA-176412|reactome:R-HSA-176417|reactome:R-HSA-2299718|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-2565942|reactome:R-HSA-2980767|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-68881|reactome:R-HSA-68884|reactome:R-HSA-69273|reactome:R-HSA-8852276|reactome:R-HSA-8854518|reactome:R-HSA-9648025|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|go:"GO:1904776"(regulation of protein localization to cell cortex)|go:"GO:1905784"(regulation of anaphase-promoting complex-dependent catabolic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000959(POLO box duplicated region)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033695|interpro:IPR033701|interpro:IPR033702|interpro:IPR036947|mint:P53350|rcsb pdb:1Q4K|rcsb pdb:1Q4O|rcsb pdb:1UMW|rcsb pdb:2OGQ|rcsb pdb:2OJX|rcsb pdb:2OU7|rcsb pdb:2OWB|rcsb pdb:2RKU|rcsb pdb:2V5Q|rcsb pdb:2YAC|rcsb pdb:3BZI|rcsb pdb:3C5L|rcsb pdb:3FC2|rcsb pdb:3FVH|rcsb pdb:3HIH|rcsb pdb:3HIK|rcsb pdb:3KB7|rcsb pdb:3P2W|rcsb pdb:3P2Z|rcsb pdb:3P34|rcsb pdb:3P35|rcsb pdb:3P36|rcsb pdb:3P37|rcsb pdb:3Q1I|rcsb pdb:3RQ7|rcsb pdb:3THB|rcsb pdb:4A4L|rcsb pdb:4A4O|dip:DIP-29696N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:5uvsgAipzkqnIHoUbjFfGR9vHS09606 rogid:fBOK366hV6mDprx9IWhz43gPcJE9606 intact-crc:D787D8264DC9F4C7|rigid:WGC9ejC4CBnQUHLmKbKnYJSEJNo false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y2K6 uniprotkb:O75943 intact:EBI-2511991|ensembl:ENSP00000313811|ensembl:ENSP00000351122|ensembl:ENSP00000361506|intact:EBI-28979612|uniprotkb:Q9UQN8|uniprotkb:Q8IXQ1|uniprotkb:Q9UQP0|uniprotkb:Q96LG5|uniprotkb:Q541F1 intact:EBI-968231|ensembl:ENSP00000484854|ensembl:ENSP00000370151|ensembl:ENSP00000426191|ensembl:ENSP00000477962|ensembl:ENSP00000477996|ensembl:ENSP00000478167|ensembl:ENSP00000479160|ensembl:ENSP00000482371|uniprotkb:O75714|uniprotkb:Q7Z3S4|uniprotkb:Q9UNK7|uniprotkb:Q9UNR7|uniprotkb:Q9UNR8|uniprotkb:Q9UPF5|uniprotkb:A8K8X2|uniprotkb:D3DWA5 psi-mi:ubp20_human(display_long)|uniprotkb:USP20(gene name)|psi-mi:USP20(display_short)|uniprotkb:KIAA1003(gene name synonym)|uniprotkb:LSFR3A(gene name synonym)|uniprotkb:VDU2(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 20(gene name synonym)|uniprotkb:Deubiquitinating enzyme 20(gene name synonym)|uniprotkb:VHL-interacting deubiquitinating enzyme 2(gene name synonym)|uniprotkb:Ubiquitin thioesterase 20(gene name synonym) psi-mi:rad17_human(display_long)|uniprotkb:R24L(gene name synonym)|uniprotkb:RAD17(gene name)|psi-mi:RAD17(display_short)|uniprotkb:RF-C/activator 1 homolog(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512022|imex:IM-12079-70 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENST00000315480(transcript)|ensembl:ENST00000358355(transcript)|ensembl:ENST00000372429(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006897"(endocytosis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|ensembl:ENSG00000136878(gene)|interpro:IPR028889|interpro:IPR035927|interpro:IPR038765|mint:Q9Y2K6|rcsb pdb:6KCZ|reactome:R-HSA-5689880|refseq:XP_011516463.1|refseq:XP_011516464.1|ensembl:ENSP00000313811|ensembl:ENSP00000351122|ensembl:ENSP00000361506|refseq:NP_001008563.2|refseq:NP_001103773.2|refseq:NP_006667.3|refseq:XP_005251722.1 ensembl:ENST00000380774(transcript)|ensembl:ENST00000509734(transcript)|ensembl:ENST00000610770(transcript)|ensembl:ENST00000611523(transcript)|ensembl:ENST00000612044(transcript)|ensembl:ENST00000616488(transcript)|ensembl:ENST00000616759(transcript)|ensembl:ENST00000620889(transcript)|go:"GO:0000076"(DNA replication checkpoint signaling)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0003682"(chromatin binding)|go:"GO:0003689"(DNA clamp loader activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008156"(negative regulation of DNA replication)|go:"GO:0031389"(Rad17 RFC-like complex)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0033314"(mitotic DNA replication checkpoint signaling)|go:"GO:0042325"(regulation of phosphorylation)|ensembl:ENSG00000152942(gene)|ensembl:ENSG00000276618(gene)|reactome:R-HSA-69473|interpro:IPR004582(Checkpoint protein Rad24)|interpro:IPR018324|interpro:IPR027417|mint:O75943|reactome:R-HSA-176187|reactome:R-HSA-5685938|reactome:R-HSA-5693607|reactome:R-HSA-5693616|reactome:R-HSA-6804756|refseq:NP_001265551.1|refseq:NP_002864.1|refseq:NP_579916.1|refseq:NP_579917.1|refseq:NP_579918.1|refseq:NP_579919.1|refseq:NP_579920.1|refseq:NP_579921.1|refseq:NP_579922.1|refseq:XP_016865168.1|refseq:XP_016865169.1|refseq:XP_016865170.1|dip:DIP-24254N|dip:DIP-34896N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:5uvsgAipzkqnIHoUbjFfGR9vHS09606 rogid:VFPeq06ilaDd09F/gQm6Dtvny2A9606 intact-crc:D787D8264DC9F4C7|rigid:WGC9ejC4CBnQUHLmKbKnYJSEJNo false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y2K6 uniprotkb:O00231 intact:EBI-2511991|ensembl:ENSP00000313811|ensembl:ENSP00000351122|ensembl:ENSP00000361506|intact:EBI-28979612|uniprotkb:Q9UQN8|uniprotkb:Q8IXQ1|uniprotkb:Q9UQP0|uniprotkb:Q96LG5|uniprotkb:Q541F1 intact:EBI-357816|uniprotkb:O00495|uniprotkb:A8K3I7|uniprotkb:E1P663|uniprotkb:Q53FT5|ensembl:ENSP00000261712|ensembl:ENSP00000393185|ensembl:ENSP00000497128 psi-mi:ubp20_human(display_long)|uniprotkb:USP20(gene name)|psi-mi:USP20(display_short)|uniprotkb:KIAA1003(gene name synonym)|uniprotkb:LSFR3A(gene name synonym)|uniprotkb:VDU2(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 20(gene name synonym)|uniprotkb:Deubiquitinating enzyme 20(gene name synonym)|uniprotkb:VHL-interacting deubiquitinating enzyme 2(gene name synonym)|uniprotkb:Ubiquitin thioesterase 20(gene name synonym) psi-mi:psd11_human(display_long)|uniprotkb:PSMD11(gene name)|psi-mi:PSMD11(display_short)|uniprotkb:26S proteasome regulatory subunit S9(gene name synonym)|uniprotkb:26S proteasome regulatory subunit p44.5(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN6(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512022|imex:IM-12079-70 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENST00000315480(transcript)|ensembl:ENST00000358355(transcript)|ensembl:ENST00000372429(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006897"(endocytosis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|ensembl:ENSG00000136878(gene)|interpro:IPR028889|interpro:IPR035927|interpro:IPR038765|mint:Q9Y2K6|rcsb pdb:6KCZ|reactome:R-HSA-5689880|refseq:XP_011516463.1|refseq:XP_011516464.1|ensembl:ENSP00000313811|ensembl:ENSP00000351122|ensembl:ENSP00000361506|refseq:NP_001008563.2|refseq:NP_001103773.2|refseq:NP_006667.3|refseq:XP_005251722.1 refseq:NP_002806.2|refseq:NP_001257411.1|ensembl:ENSG00000108671(gene)|ensembl:ENST00000261712(transcript)|ensembl:ENST00000457654(transcript)|ensembl:ENST00000649012(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008541"(proteasome regulatory particle, lid subcomplex)|go:"GO:0016020"(membrane)|go:"GO:0022624"(proteasome accessory complex)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0043248"(proteasome assembly)|go:"GO:0048863"(stem cell differentiation)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR035295|interpro:IPR036390|interpro:IPR040773|interpro:IPR040780|mint:O00231|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5M32|rcsb pdb:5LN3|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VGZ|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHS|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-6798695|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:5uvsgAipzkqnIHoUbjFfGR9vHS09606 rogid:BgQKXK7gMMihacRCI+g/pBnRN309606 intact-crc:D787D8264DC9F4C7|rigid:WGC9ejC4CBnQUHLmKbKnYJSEJNo false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y2K6 uniprotkb:O00159 intact:EBI-2511991|ensembl:ENSP00000313811|ensembl:ENSP00000351122|ensembl:ENSP00000361506|intact:EBI-28979612|uniprotkb:Q9UQN8|uniprotkb:Q8IXQ1|uniprotkb:Q9UQP0|uniprotkb:Q96LG5|uniprotkb:Q541F1 intact:EBI-350423|uniprotkb:Q6NVJ7|intact:EBI-1045431|uniprotkb:Q86Y95|uniprotkb:Q4LE56|ensembl:ENSP00000496954 psi-mi:ubp20_human(display_long)|uniprotkb:USP20(gene name)|psi-mi:USP20(display_short)|uniprotkb:KIAA1003(gene name synonym)|uniprotkb:LSFR3A(gene name synonym)|uniprotkb:VDU2(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 20(gene name synonym)|uniprotkb:Deubiquitinating enzyme 20(gene name synonym)|uniprotkb:VHL-interacting deubiquitinating enzyme 2(gene name synonym)|uniprotkb:Ubiquitin thioesterase 20(gene name synonym) psi-mi:myo1c_human(display_long)|uniprotkb:MYO1C(gene name)|psi-mi:MYO1C(display_short)|uniprotkb:Myosin I beta(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512022|imex:IM-12079-70 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENST00000315480(transcript)|ensembl:ENST00000358355(transcript)|ensembl:ENST00000372429(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006897"(endocytosis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|ensembl:ENSG00000136878(gene)|interpro:IPR028889|interpro:IPR035927|interpro:IPR038765|mint:Q9Y2K6|rcsb pdb:6KCZ|reactome:R-HSA-5689880|refseq:XP_011516463.1|refseq:XP_011516464.1|ensembl:ENSP00000313811|ensembl:ENSP00000351122|ensembl:ENSP00000361506|refseq:NP_001008563.2|refseq:NP_001103773.2|refseq:NP_006667.3|refseq:XP_005251722.1 go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0005903"(brush border)|go:"GO:0006605"(protein targeting)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0007015"(actin filament organization)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016461"(unconventional myosin complex)|go:"GO:0005829"(cytosol)|go:"GO:0030050"(vesicle transport along actin filament)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0016604"(nuclear body)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0031982"(vesicle)|go:"GO:0032587"(ruffle membrane)|go:"GO:0038089"(positive regulation of cell migration by vascular endothelial growth factor signaling pathway)|go:"GO:0045121"(membrane raft)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0051015"(actin filament binding)|go:"GO:0051028"(mRNA transport)|go:"GO:0060171"(stereocilium membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:1900078"(positive regulation of cellular response to insulin stimulus)|refseq:NP_001074248.1|refseq:NP_001074419.1|refseq:NP_203693.3|ensembl:ENSG00000197879(gene)|ensembl:ENST00000648651(transcript)|go:"GO:0000146"(microfilament motor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:2000810"(regulation of bicellular tight junction assembly)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR001609(Myosin head, motor region)|interpro:IPR010926(Myosin tail 2)|interpro:IPR027417|interpro:IPR036072|interpro:IPR036961|mint:O00159|rcsb pdb:4BYF|reactome:R-HSA-1445148|reactome:R-HSA-2029482|reactome:R-HSA-5250924|reactome:R-HSA-9662360|go:"GO:1900748"(positive regulation of vascular endothelial growth factor signaling pathway)|reactome:R-HSA-9662361|reactome:R-HSA-9664422|dip:DIP-33109N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:5uvsgAipzkqnIHoUbjFfGR9vHS09606 rogid:g6wQN0OVKjd3T1kOebWFcqWNzNA9606 intact-crc:D787D8264DC9F4C7|rigid:WGC9ejC4CBnQUHLmKbKnYJSEJNo false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y2K6 uniprotkb:P49790 intact:EBI-2511991|ensembl:ENSP00000313811|ensembl:ENSP00000351122|ensembl:ENSP00000361506|intact:EBI-28979612|uniprotkb:Q9UQN8|uniprotkb:Q8IXQ1|uniprotkb:Q9UQP0|uniprotkb:Q96LG5|uniprotkb:Q541F1 intact:EBI-286779|uniprotkb:Q5T9I7|intact:EBI-1237421|uniprotkb:E7EPX5|uniprotkb:Q4LE47|uniprotkb:Q7Z743|uniprotkb:B4DIK2|uniprotkb:F6QR24|ensembl:ENSP00000262077 psi-mi:ubp20_human(display_long)|uniprotkb:USP20(gene name)|psi-mi:USP20(display_short)|uniprotkb:KIAA1003(gene name synonym)|uniprotkb:LSFR3A(gene name synonym)|uniprotkb:VDU2(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 20(gene name synonym)|uniprotkb:Deubiquitinating enzyme 20(gene name synonym)|uniprotkb:VHL-interacting deubiquitinating enzyme 2(gene name synonym)|uniprotkb:Ubiquitin thioesterase 20(gene name synonym) psi-mi:nu153_human(display_long)|uniprotkb:Nucleoporin Nup153(gene name synonym)|uniprotkb:153 kDa nucleoporin(gene name synonym)|uniprotkb:NUP153(gene name)|psi-mi:NUP153(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512022|imex:IM-12079-70 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENST00000315480(transcript)|ensembl:ENST00000358355(transcript)|ensembl:ENST00000372429(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006897"(endocytosis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|ensembl:ENSG00000136878(gene)|interpro:IPR028889|interpro:IPR035927|interpro:IPR038765|mint:Q9Y2K6|rcsb pdb:6KCZ|reactome:R-HSA-5689880|refseq:XP_011516463.1|refseq:XP_011516464.1|ensembl:ENSP00000313811|ensembl:ENSP00000351122|ensembl:ENSP00000361506|refseq:NP_001008563.2|refseq:NP_001103773.2|refseq:NP_006667.3|refseq:XP_005251722.1 ensembl:ENSP00000262077|ensembl:ENST00000537253|ensembl:ENSP00000444029|ensembl:ENST00000613258|ensembl:ENSP00000478627|refseq:NP_005115.2|refseq:NP_001265138.1|refseq:NP_001265139.1|dip:DIP-38185N|ensembl:ENSG00000124789(gene)|ensembl:ENST00000262077(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006405"(RNA export from nucleus)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0016020"(membrane)|go:"GO:0017056"(structural constituent of nuclear pore)|go:"GO:0031965"(nuclear membrane)|go:"GO:0034399"(nuclear periphery)|go:"GO:0042405"(nuclear inclusion body)|go:"GO:0042802"(identical protein binding)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0043657"(host cell)|go:"GO:0044615"(nuclear pore nuclear basket)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046832"(negative regulation of RNA export from nucleus)|go:"GO:0046872"(metal ion binding)|go:"GO:0051028"(mRNA transport)|go:"GO:0051292"(nuclear pore complex assembly)|go:"GO:0075732"(viral penetration into host nucleus)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR013913(Nucleoporin, Nup153-like)|interpro:IPR018892|interpro:IPR026054|interpro:IPR036443|mint:P49790|rcsb pdb:2EBQ|rcsb pdb:2EBR|rcsb pdb:2EBV|rcsb pdb:2GQE|rcsb pdb:4U0C|rcsb pdb:4U0D|rcsb pdb:5TSV|rcsb pdb:5TSX|rcsb pdb:6AYA|reactome:R-HSA-1169408|reactome:R-HSA-159227|reactome:R-HSA-159230|reactome:R-HSA-159231|reactome:R-HSA-159236|reactome:R-HSA-165054|reactome:R-HSA-168271|reactome:R-HSA-168276|reactome:R-HSA-168325|reactome:R-HSA-168333|reactome:R-HSA-170822|reactome:R-HSA-180746|reactome:R-HSA-180910|reactome:R-HSA-191859|reactome:R-HSA-3108214|reactome:R-HSA-3232142|reactome:R-HSA-3301854|reactome:R-HSA-3371453|reactome:R-HSA-4085377|reactome:R-HSA-4551638|reactome:R-HSA-4570464|reactome:R-HSA-4615885|reactome:R-HSA-5578749|reactome:R-HSA-5619107|reactome:R-HSA-6784531|reactome:R-HSA-9609690|reactome:R-HSA-9610379 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:5uvsgAipzkqnIHoUbjFfGR9vHS09606 rogid:rOax/ikcAu5fmDiCOauVr7Y/fzY9606 intact-crc:D787D8264DC9F4C7|rigid:WGC9ejC4CBnQUHLmKbKnYJSEJNo false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y2K6 uniprotkb:P51665 intact:EBI-2511991|ensembl:ENSP00000313811|ensembl:ENSP00000351122|ensembl:ENSP00000361506|intact:EBI-28979612|uniprotkb:Q9UQN8|uniprotkb:Q8IXQ1|uniprotkb:Q9UQP0|uniprotkb:Q96LG5|uniprotkb:Q541F1 intact:EBI-357659|uniprotkb:Q6PKI2|uniprotkb:Q96E97|ensembl:ENSP00000219313|uniprotkb:D3DWS9 psi-mi:ubp20_human(display_long)|uniprotkb:USP20(gene name)|psi-mi:USP20(display_short)|uniprotkb:KIAA1003(gene name synonym)|uniprotkb:LSFR3A(gene name synonym)|uniprotkb:VDU2(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 20(gene name synonym)|uniprotkb:Deubiquitinating enzyme 20(gene name synonym)|uniprotkb:VHL-interacting deubiquitinating enzyme 2(gene name synonym)|uniprotkb:Ubiquitin thioesterase 20(gene name synonym) psi-mi:psmd7_human(display_long)|uniprotkb:PSMD7(gene name)|psi-mi:PSMD7(display_short)|uniprotkb:MOV34L(gene name synonym)|uniprotkb:26S proteasome regulatory subunit RPN8(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S12(gene name synonym)|uniprotkb:Proteasome subunit p40(gene name synonym)|uniprotkb:Mov34 protein homolog(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512022|imex:IM-12079-70 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENST00000315480(transcript)|ensembl:ENST00000358355(transcript)|ensembl:ENST00000372429(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006897"(endocytosis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|ensembl:ENSG00000136878(gene)|interpro:IPR028889|interpro:IPR035927|interpro:IPR038765|mint:Q9Y2K6|rcsb pdb:6KCZ|reactome:R-HSA-5689880|refseq:XP_011516463.1|refseq:XP_011516464.1|ensembl:ENSP00000313811|ensembl:ENSP00000351122|ensembl:ENSP00000361506|refseq:NP_001008563.2|refseq:NP_001103773.2|refseq:NP_006667.3|refseq:XP_005251722.1 refseq:NP_002802.2|rcsb pdb:5T0J|ensembl:ENSG00000103035(gene)|ensembl:ENST00000219313(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005838"(proteasome regulatory particle)|go:"GO:0016020"(membrane)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070122"(isopeptidase activity)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR024969|interpro:IPR033858|interpro:IPR037518|mint:P51665|rcsb pdb:2O95|rcsb pdb:2O96|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4K|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:5VGZ|rcsb pdb:5VHF|rcsb pdb:5VHH|rcsb pdb:5VHI|rcsb pdb:5VHS|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6WJD|rcsb pdb:6WJN|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-180534|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-195253|reactome:R-HSA-5676590|reactome:R-HSA-202424|reactome:R-HSA-5678895|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-2871837|reactome:R-HSA-5689880|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-6798695|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-68827|reactome:R-HSA-4641258|reactome:R-HSA-68949|reactome:R-HSA-5358346|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|dip:DIP-27572N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:5uvsgAipzkqnIHoUbjFfGR9vHS09606 rogid:HJaBTx4pIiSDIArqueuNRvhzVvU9606 intact-crc:D787D8264DC9F4C7|rigid:WGC9ejC4CBnQUHLmKbKnYJSEJNo false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y2K6 uniprotkb:Q96AG4 intact:EBI-2511991|ensembl:ENSP00000313811|ensembl:ENSP00000351122|ensembl:ENSP00000361506|intact:EBI-28979612|uniprotkb:Q9UQN8|uniprotkb:Q8IXQ1|uniprotkb:Q9UQP0|uniprotkb:Q96LG5|uniprotkb:Q541F1 intact:EBI-358888|uniprotkb:Q9P189|uniprotkb:D3DTX8|ensembl:ENSP00000225972|uniprotkb:B2RE83 psi-mi:ubp20_human(display_long)|uniprotkb:USP20(gene name)|psi-mi:USP20(display_short)|uniprotkb:KIAA1003(gene name synonym)|uniprotkb:LSFR3A(gene name synonym)|uniprotkb:VDU2(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 20(gene name synonym)|uniprotkb:Deubiquitinating enzyme 20(gene name synonym)|uniprotkb:VHL-interacting deubiquitinating enzyme 2(gene name synonym)|uniprotkb:Ubiquitin thioesterase 20(gene name synonym) psi-mi:lrc59_human(display_long)|uniprotkb:LRRC59(gene name)|psi-mi:LRRC59(display_short)|uniprotkb:Ribosome-binding protein p34(gene name synonym)|uniprotkb:PRO1855(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512022|imex:IM-12079-70 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENST00000315480(transcript)|ensembl:ENST00000358355(transcript)|ensembl:ENST00000372429(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006897"(endocytosis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|ensembl:ENSG00000136878(gene)|interpro:IPR028889|interpro:IPR035927|interpro:IPR038765|mint:Q9Y2K6|rcsb pdb:6KCZ|reactome:R-HSA-5689880|refseq:XP_011516463.1|refseq:XP_011516464.1|ensembl:ENSP00000313811|ensembl:ENSP00000351122|ensembl:ENSP00000361506|refseq:NP_001008563.2|refseq:NP_001103773.2|refseq:NP_006667.3|refseq:XP_005251722.1 refseq:NP_060979.2|ensembl:ENSG00000108829(gene)|ensembl:ENST00000225972(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0045296"(cadherin binding)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR032675|mint:Q96AG4 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:5uvsgAipzkqnIHoUbjFfGR9vHS09606 rogid:gAtWed9Jv69oHdkEFgpWGFnvcWE9606 intact-crc:D787D8264DC9F4C7|rigid:WGC9ejC4CBnQUHLmKbKnYJSEJNo false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y2K6 uniprotkb:O75787 intact:EBI-2511991|ensembl:ENSP00000313811|ensembl:ENSP00000351122|ensembl:ENSP00000361506|intact:EBI-28979612|uniprotkb:Q9UQN8|uniprotkb:Q8IXQ1|uniprotkb:Q9UQP0|uniprotkb:Q96LG5|uniprotkb:Q541F1 intact:EBI-2512037|ensembl:ENSP00000490083|uniprotkb:B7Z9I3|uniprotkb:Q8NG15|uniprotkb:Q8NBP3|uniprotkb:Q5QTQ7|uniprotkb:Q9UG89|uniprotkb:Q96FV6|uniprotkb:Q9H2P8|uniprotkb:Q96LB5|uniprotkb:Q6T7F5 psi-mi:ubp20_human(display_long)|uniprotkb:USP20(gene name)|psi-mi:USP20(display_short)|uniprotkb:KIAA1003(gene name synonym)|uniprotkb:LSFR3A(gene name synonym)|uniprotkb:VDU2(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 20(gene name synonym)|uniprotkb:Deubiquitinating enzyme 20(gene name synonym)|uniprotkb:VHL-interacting deubiquitinating enzyme 2(gene name synonym)|uniprotkb:Ubiquitin thioesterase 20(gene name synonym) psi-mi:renr_human(display_long)|uniprotkb:ATP6AP2(gene name)|psi-mi:ATP6AP2(display_short)|uniprotkb:ATP6IP2(gene name synonym)|uniprotkb:CAPER(gene name synonym)|uniprotkb:ELDF10(gene name synonym)|uniprotkb:Renin/prorenin receptor(gene name synonym)|uniprotkb:"ATPase H(+)-transporting lysosomal accessory protein 2"(gene name synonym)|uniprotkb:"ATPase H(+)-transporting lysosomal-interacting protein 2"(gene name synonym)|uniprotkb:Vacuolar ATP synthase membrane sector-associated protein M8-9(gene name synonym)|uniprotkb:N14F(gene name synonym)|uniprotkb:Embryonic liver differentiation factor 10(gene name synonym)|uniprotkb:HT028(orf name)|uniprotkb:MSTP009(orf name)|uniprotkb:PSEC0072(orf name)|uniprotkb:ER-localized type I transmembrane adapter(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512022|imex:IM-12079-70 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENST00000315480(transcript)|ensembl:ENST00000358355(transcript)|ensembl:ENST00000372429(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006897"(endocytosis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|ensembl:ENSG00000136878(gene)|interpro:IPR028889|interpro:IPR035927|interpro:IPR038765|mint:Q9Y2K6|rcsb pdb:6KCZ|reactome:R-HSA-5689880|refseq:XP_011516463.1|refseq:XP_011516464.1|ensembl:ENSP00000313811|ensembl:ENSP00000351122|ensembl:ENSP00000361506|refseq:NP_001008563.2|refseq:NP_001103773.2|refseq:NP_006667.3|refseq:XP_005251722.1 ensembl:ENSG00000182220(gene)|ensembl:ENST00000636580(transcript)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0002003"(angiotensin maturation)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007042"(lysosomal lumen acidification)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010008"(endosome membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016471"(vacuolar proton-transporting V-type ATPase complex)|go:"GO:0021626"(central nervous system maturation)|go:"GO:0021903"(rostrocaudal neural tube patterning)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0030424"(axon)|go:"GO:0032591"(dendritic spine membrane)|go:"GO:0032914"(positive regulation of transforming growth factor beta1 production)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0044297"(cell body)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048069"(eye pigmentation)|go:"GO:0060323"(head morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0101003"(ficolin-1-rich granule membrane)|interpro:IPR012493(Renin receptor-like)|mint:O75787|rcsb pdb:3LBS|rcsb pdb:3LC8|rcsb pdb:6WLW|rcsb pdb:6WM2|rcsb pdb:6WM3|rcsb pdb:6WM4|reactome:R-HSA-2022377|reactome:R-HSA-6798695|refseq:NP_005756.2 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:5uvsgAipzkqnIHoUbjFfGR9vHS09606 rogid:v4lEPX23LdYqPi8dQX4MZG+tQZg9606 intact-crc:D787D8264DC9F4C7|rigid:WGC9ejC4CBnQUHLmKbKnYJSEJNo false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y2K6 uniprotkb:P15374 intact:EBI-2511991|ensembl:ENSP00000313811|ensembl:ENSP00000351122|ensembl:ENSP00000361506|intact:EBI-28979612|uniprotkb:Q9UQN8|uniprotkb:Q8IXQ1|uniprotkb:Q9UQP0|uniprotkb:Q96LG5|uniprotkb:Q541F1 intact:EBI-954554|uniprotkb:Q5TBK8|uniprotkb:Q6IBE9|ensembl:ENSP00000366819|uniprotkb:B2R970 psi-mi:ubp20_human(display_long)|uniprotkb:USP20(gene name)|psi-mi:USP20(display_short)|uniprotkb:KIAA1003(gene name synonym)|uniprotkb:LSFR3A(gene name synonym)|uniprotkb:VDU2(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 20(gene name synonym)|uniprotkb:Deubiquitinating enzyme 20(gene name synonym)|uniprotkb:VHL-interacting deubiquitinating enzyme 2(gene name synonym)|uniprotkb:Ubiquitin thioesterase 20(gene name synonym) psi-mi:uchl3_human(display_long)|uniprotkb:Ubiquitin thioesterase L3(gene name synonym)|uniprotkb:UCHL3(gene name)|psi-mi:UCHL3(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512022|imex:IM-12079-70 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENST00000315480(transcript)|ensembl:ENST00000358355(transcript)|ensembl:ENST00000372429(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006897"(endocytosis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|ensembl:ENSG00000136878(gene)|interpro:IPR028889|interpro:IPR035927|interpro:IPR038765|mint:Q9Y2K6|rcsb pdb:6KCZ|reactome:R-HSA-5689880|refseq:XP_011516463.1|refseq:XP_011516464.1|ensembl:ENSP00000313811|ensembl:ENSP00000351122|ensembl:ENSP00000361506|refseq:NP_001008563.2|refseq:NP_001103773.2|refseq:NP_006667.3|refseq:XP_005251722.1 refseq:NP_001257881.1|refseq:NP_005993.1|ensembl:ENSG00000118939(gene)|ensembl:ENST00000377595(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008233"(peptidase activity)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019784"(NEDD8-specific protease activity)|go:"GO:0030163"(protein catabolic process)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043687"(post-translational protein modification)|interpro:IPR001578(Peptidase C12, ubiquitin carboxyl-terminal hydrolase 1)|interpro:IPR036959|interpro:IPR038765|rcsb pdb:1UCH|rcsb pdb:1XD3|rcsb pdb:6ISU|rcsb pdb:6QML|reactome:R-HSA-5689603|reactome:R-HSA-8866652|reactome:R-HSA-8951664|dip:DIP-29135N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:5uvsgAipzkqnIHoUbjFfGR9vHS09606 rogid:cPnctBpxrgvBKBSaQmhCsyd2nRM9606 intact-crc:D787D8264DC9F4C7|rigid:WGC9ejC4CBnQUHLmKbKnYJSEJNo false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y2K6 uniprotkb:Q6IQ23 intact:EBI-2511991|ensembl:ENSP00000313811|ensembl:ENSP00000351122|ensembl:ENSP00000361506|intact:EBI-28979612|uniprotkb:Q9UQN8|uniprotkb:Q8IXQ1|uniprotkb:Q9UQP0|uniprotkb:Q96LG5|uniprotkb:Q541F1 intact:EBI-2125301|uniprotkb:Q86VZ7|uniprotkb:B4DK33|uniprotkb:B4DWC3|intact:EBI-28977101|ensembl:ENSP00000347883 psi-mi:ubp20_human(display_long)|uniprotkb:USP20(gene name)|psi-mi:USP20(display_short)|uniprotkb:KIAA1003(gene name synonym)|uniprotkb:LSFR3A(gene name synonym)|uniprotkb:VDU2(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 20(gene name synonym)|uniprotkb:Deubiquitinating enzyme 20(gene name synonym)|uniprotkb:VHL-interacting deubiquitinating enzyme 2(gene name synonym)|uniprotkb:Ubiquitin thioesterase 20(gene name synonym) psi-mi:pkha7_human(display_long)|uniprotkb:PLEKHA7(gene name)|psi-mi:PLEKHA7(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512022|imex:IM-12079-70 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENST00000315480(transcript)|ensembl:ENST00000358355(transcript)|ensembl:ENST00000372429(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006897"(endocytosis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|ensembl:ENSG00000136878(gene)|interpro:IPR028889|interpro:IPR035927|interpro:IPR038765|mint:Q9Y2K6|rcsb pdb:6KCZ|reactome:R-HSA-5689880|refseq:XP_011516463.1|refseq:XP_011516464.1|ensembl:ENSP00000313811|ensembl:ENSP00000351122|ensembl:ENSP00000361506|refseq:NP_001008563.2|refseq:NP_001103773.2|refseq:NP_006667.3|refseq:XP_005251722.1 refseq:NP_778228.3|ensembl:ENSP00000347883|refseq:NP_001316559.1|refseq:NP_001316560.1|ensembl:ENSG00000166689(gene)|ensembl:ENST00000355661(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005915"(zonula adherens)|go:"GO:0030054"(cell junction)|go:"GO:0044331"(cell-cell adhesion mediated by cadherin)|go:"GO:0045218"(zonula adherens maintenance)|go:"GO:0046930"(pore complex)|go:"GO:0046931"(pore complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070097"(delta-catenin binding)|go:"GO:0090136"(epithelial cell-cell adhesion)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR036020|interpro:IPR040392|rcsb pdb:7KJO|rcsb pdb:7KJZ|rcsb pdb:7KK7 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:5uvsgAipzkqnIHoUbjFfGR9vHS09606 rogid:AqLJ+GSULYT7MByw7FZAgPXxir49606 intact-crc:D787D8264DC9F4C7|rigid:WGC9ejC4CBnQUHLmKbKnYJSEJNo false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y2K6 uniprotkb:O95292 intact:EBI-2511991|ensembl:ENSP00000313811|ensembl:ENSP00000351122|ensembl:ENSP00000361506|intact:EBI-28979612|uniprotkb:Q9UQN8|uniprotkb:Q8IXQ1|uniprotkb:Q9UQP0|uniprotkb:Q96LG5|uniprotkb:Q541F1 intact:EBI-1188298|uniprotkb:O95293|uniprotkb:Q9P0H0|uniprotkb:A2A2F2|ensembl:ENSP00000417175 psi-mi:ubp20_human(display_long)|uniprotkb:USP20(gene name)|psi-mi:USP20(display_short)|uniprotkb:KIAA1003(gene name synonym)|uniprotkb:LSFR3A(gene name synonym)|uniprotkb:VDU2(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 20(gene name synonym)|uniprotkb:Deubiquitinating enzyme 20(gene name synonym)|uniprotkb:VHL-interacting deubiquitinating enzyme 2(gene name synonym)|uniprotkb:Ubiquitin thioesterase 20(gene name synonym) psi-mi:vapb_human(display_long)|uniprotkb:VAPB(gene name)|psi-mi:VAPB(display_short)|uniprotkb:UNQ484/PRO983(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512022|imex:IM-12079-70 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENST00000315480(transcript)|ensembl:ENST00000358355(transcript)|ensembl:ENST00000372429(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006897"(endocytosis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|ensembl:ENSG00000136878(gene)|interpro:IPR028889|interpro:IPR035927|interpro:IPR038765|mint:Q9Y2K6|rcsb pdb:6KCZ|reactome:R-HSA-5689880|refseq:XP_011516463.1|refseq:XP_011516464.1|ensembl:ENSP00000313811|ensembl:ENSP00000351122|ensembl:ENSP00000361506|refseq:NP_001008563.2|refseq:NP_001103773.2|refseq:NP_006667.3|refseq:XP_005251722.1 refseq:NP_001182606.1|refseq:NP_004729.1|ensembl:ENSG00000124164(gene)|ensembl:ENST00000475243(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0008017"(microtubule binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019048"(modulation by virus of host process)|go:"GO:0019899"(enzyme binding)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0033149"(FFAT motif binding)|go:"GO:0036498"(IRE1-mediated unfolded protein response)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044790"(suppression of viral release by host)|go:"GO:0044791"(obsolete positive regulation by host of viral release from host cell)|go:"GO:0044828"(negative regulation by host of viral genome replication)|go:"GO:0044829"(positive regulation by host of viral genome replication)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0045296"(cadherin binding)|go:"GO:0046725"(negative regulation by virus of viral protein levels in host cell)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0061817"(endoplasmic reticulum-plasma membrane tethering)|go:"GO:0090114"(COPII-coated vesicle budding)|go:"GO:0090158"(endoplasmic reticulum membrane organization)|interpro:IPR000535(Major sperm protein)|interpro:IPR008962(PapD-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016763(Vesicle-associated membrane protein)|mint:O95292|rcsb pdb:2MDK|rcsb pdb:3IKK|reactome:R-HSA-1660661|reactome:R-HSA-8980692|reactome:R-HSA-9013106|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013408|dip:DIP-39816N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:5uvsgAipzkqnIHoUbjFfGR9vHS09606 rogid:+TuApjAmnGF1UZonXIsrPaIN4Ak9606 intact-crc:D787D8264DC9F4C7|rigid:WGC9ejC4CBnQUHLmKbKnYJSEJNo false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y2K6 uniprotkb:Q99767 intact:EBI-2511991|ensembl:ENSP00000313811|ensembl:ENSP00000351122|ensembl:ENSP00000361506|intact:EBI-28979612|uniprotkb:Q9UQN8|uniprotkb:Q8IXQ1|uniprotkb:Q9UQP0|uniprotkb:Q96LG5|uniprotkb:Q541F1 intact:EBI-81711|uniprotkb:O60571|ensembl:ENSP00000453144|ensembl:ENSP00000453293|ensembl:ENSP00000454171|ensembl:ENSP00000480384|ensembl:ENSP00000488107|ensembl:ENSP00000507394|uniprotkb:E9PGI4|uniprotkb:Q5XKC0 psi-mi:ubp20_human(display_long)|uniprotkb:USP20(gene name)|psi-mi:USP20(display_short)|uniprotkb:KIAA1003(gene name synonym)|uniprotkb:LSFR3A(gene name synonym)|uniprotkb:VDU2(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 20(gene name synonym)|uniprotkb:Deubiquitinating enzyme 20(gene name synonym)|uniprotkb:VHL-interacting deubiquitinating enzyme 2(gene name synonym)|uniprotkb:Ubiquitin thioesterase 20(gene name synonym) psi-mi:apba2_human(display_long)|uniprotkb:APBA2(gene name)|psi-mi:APBA2(display_short)|uniprotkb:MINT2(gene name synonym)|uniprotkb:X11L(gene name synonym)|uniprotkb:Neuron-specific X11L protein(gene name synonym)|uniprotkb:Neuronal Munc18-1-interacting protein 2(gene name synonym)|uniprotkb:Adapter protein X11beta(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512022|imex:IM-12079-70 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENST00000315480(transcript)|ensembl:ENST00000358355(transcript)|ensembl:ENST00000372429(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006897"(endocytosis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|ensembl:ENSG00000136878(gene)|interpro:IPR028889|interpro:IPR035927|interpro:IPR038765|mint:Q9Y2K6|rcsb pdb:6KCZ|reactome:R-HSA-5689880|refseq:XP_011516463.1|refseq:XP_011516464.1|ensembl:ENSP00000313811|ensembl:ENSP00000351122|ensembl:ENSP00000361506|refseq:NP_001008563.2|refseq:NP_001103773.2|refseq:NP_006667.3|refseq:XP_005251722.1 refseq:NP_001123886.1|refseq:NP_005494.2|refseq:XP_016877590.1|refseq:XP_016877591.1|refseq:XP_016877592.1|refseq:XP_016877593.1|refseq:XP_016877594.1|refseq:XP_016877595.1|refseq:XP_016877596.1|refseq:XP_016877597.1|refseq:XP_016877598.1|refseq:XP_016877599.1|refseq:XP_016877600.1|refseq:XP_016877601.1|refseq:XP_016877602.1|refseq:XP_016877603.1|ensembl:ENSG00000034053(gene)|ensembl:ENSG00000276495(gene)|go:"GO:0042802"(identical protein binding)|go:"GO:0043197"(dendritic spine)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR030529|interpro:IPR036034|mint:Q99767|reactome:R-HSA-6794361|ensembl:ENST00000558259(transcript)|ensembl:ENST00000558402(transcript)|ensembl:ENST00000561069(transcript)|ensembl:ENST00000620457(transcript)|ensembl:ENST00000631894(transcript)|ensembl:ENST00000683413(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007399"(nervous system development)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0015031"(protein transport)|refseq:XP_011519790.1|refseq:XP_011519791.1|refseq:XP_011519792.1|refseq:XP_011519793.1|refseq:XP_011519794.1|refseq:XP_016877605.1|refseq:XP_016877606.1|refseq:XP_016877604.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:5uvsgAipzkqnIHoUbjFfGR9vHS09606 rogid:gO80zdSUhRm1hFaFBfeQyDCGh3w9606 intact-crc:D787D8264DC9F4C7|rigid:WGC9ejC4CBnQUHLmKbKnYJSEJNo false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y2K6 uniprotkb:P11310 intact:EBI-2511991|ensembl:ENSP00000313811|ensembl:ENSP00000351122|ensembl:ENSP00000361506|intact:EBI-28979612|uniprotkb:Q9UQN8|uniprotkb:Q8IXQ1|uniprotkb:Q9UQP0|uniprotkb:Q96LG5|uniprotkb:Q541F1 intact:EBI-514381|uniprotkb:Q9NYF1|uniprotkb:Q5T4U4|ensembl:ENSP00000359878 psi-mi:ubp20_human(display_long)|uniprotkb:USP20(gene name)|psi-mi:USP20(display_short)|uniprotkb:KIAA1003(gene name synonym)|uniprotkb:LSFR3A(gene name synonym)|uniprotkb:VDU2(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 20(gene name synonym)|uniprotkb:Deubiquitinating enzyme 20(gene name synonym)|uniprotkb:VHL-interacting deubiquitinating enzyme 2(gene name synonym)|uniprotkb:Ubiquitin thioesterase 20(gene name synonym) psi-mi:acadm_human(display_long)|uniprotkb:Medium chain acyl-CoA dehydrogenase(gene name synonym)|uniprotkb:ACADM(gene name)|psi-mi:ACADM(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512022|imex:IM-12079-70 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENST00000315480(transcript)|ensembl:ENST00000358355(transcript)|ensembl:ENST00000372429(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006897"(endocytosis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|ensembl:ENSG00000136878(gene)|interpro:IPR028889|interpro:IPR035927|interpro:IPR038765|mint:Q9Y2K6|rcsb pdb:6KCZ|reactome:R-HSA-5689880|refseq:XP_011516463.1|refseq:XP_011516464.1|ensembl:ENSP00000313811|ensembl:ENSP00000351122|ensembl:ENSP00000361506|refseq:NP_001008563.2|refseq:NP_001103773.2|refseq:NP_006667.3|refseq:XP_005251722.1 refseq:NP_000007.1|refseq:NP_001120800.1|dip:DIP-34281N|ensembl:ENSG00000117054(gene)|ensembl:ENST00000370841(transcript)|go:"GO:0001889"(liver development)|go:"GO:0003995"(acyl-CoA dehydrogenase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005978"(glycogen biosynthetic process)|go:"GO:0006111"(regulation of gluconeogenesis)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0009409"(response to cold)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019254"(carnitine metabolic process, CoA-linked)|go:"GO:0030424"(axon)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0033539"(fatty acid beta-oxidation using acyl-CoA dehydrogenase)|go:"GO:0042594"(response to starvation)|go:"GO:0042802"(identical protein binding)|go:"GO:0045329"(carnitine biosynthetic process)|go:"GO:0050660"(flavin adenine dinucleotide binding)|go:"GO:0051791"(medium-chain fatty acid metabolic process)|go:"GO:0051793"(medium-chain fatty acid catabolic process)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0070991"(medium-chain-acyl-CoA dehydrogenase activity)|interpro:IPR006089(Acyl-CoA dehydrogenase, conserved site)|interpro:IPR006091(Acyl-CoA dehydrogenase/oxidase, central region)|interpro:IPR009075(Acyl-CoA dehydrogenase/oxidase C-terminal)|interpro:IPR009100(Acyl-CoA dehydrogenase/oxidase, middle and N-terminal)|interpro:IPR013786(Acyl-CoA dehydrogenase/oxidase, N-terminal)|interpro:IPR034180|interpro:IPR036250|interpro:IPR037069|mint:P11310|rcsb pdb:1EGC|rcsb pdb:1EGD|rcsb pdb:1EGE|rcsb pdb:1T9G|rcsb pdb:2A1T|rcsb pdb:4P13|reactome:R-HSA-1989781|reactome:R-HSA-77288|reactome:R-HSA-77346|reactome:R-HSA-77348 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:5uvsgAipzkqnIHoUbjFfGR9vHS09606 rogid:rfmTmYKNQr6R6ikvfYovZIctoz49606 intact-crc:D787D8264DC9F4C7|rigid:WGC9ejC4CBnQUHLmKbKnYJSEJNo false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y2K6 uniprotkb:Q9UBC5 intact:EBI-2511991|ensembl:ENSP00000313811|ensembl:ENSP00000351122|ensembl:ENSP00000361506|intact:EBI-28979612|uniprotkb:Q9UQN8|uniprotkb:Q8IXQ1|uniprotkb:Q9UQP0|uniprotkb:Q96LG5|uniprotkb:Q541F1 intact:EBI-353290|uniprotkb:Q9UQD7|ensembl:ENSP00000300119|ensembl:ENSP00000393392 psi-mi:ubp20_human(display_long)|uniprotkb:USP20(gene name)|psi-mi:USP20(display_short)|uniprotkb:KIAA1003(gene name synonym)|uniprotkb:LSFR3A(gene name synonym)|uniprotkb:VDU2(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 20(gene name synonym)|uniprotkb:Deubiquitinating enzyme 20(gene name synonym)|uniprotkb:VHL-interacting deubiquitinating enzyme 2(gene name synonym)|uniprotkb:Ubiquitin thioesterase 20(gene name synonym) psi-mi:myo1a_human(display_long)|uniprotkb:MYO1A(gene name)|psi-mi:MYO1A(display_short)|uniprotkb:MYHL(gene name synonym)|uniprotkb:Brush border myosin I(gene name synonym)|uniprotkb:Myosin I heavy chain(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512022|imex:IM-12079-70 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENST00000315480(transcript)|ensembl:ENST00000358355(transcript)|ensembl:ENST00000372429(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006897"(endocytosis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|ensembl:ENSG00000136878(gene)|interpro:IPR028889|interpro:IPR035927|interpro:IPR038765|mint:Q9Y2K6|rcsb pdb:6KCZ|reactome:R-HSA-5689880|refseq:XP_011516463.1|refseq:XP_011516464.1|ensembl:ENSP00000313811|ensembl:ENSP00000351122|ensembl:ENSP00000361506|refseq:NP_001008563.2|refseq:NP_001103773.2|refseq:NP_006667.3|refseq:XP_005251722.1 refseq:NP_001242970.1|refseq:NP_005370.1|ensembl:ENSG00000166866(gene)|ensembl:ENST00000300119(transcript)|ensembl:ENST00000442789(transcript)|go:"GO:0000146"(microfilament motor activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0005903"(brush border)|go:"GO:0007015"(actin filament organization)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016459"(myosin complex)|go:"GO:0030033"(microvillus assembly)|go:"GO:0030050"(vesicle transport along actin filament)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031941"(filamentous actin)|go:"GO:0031982"(vesicle)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0051015"(actin filament binding)|go:"GO:0051648"(vesicle localization)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR001609(Myosin head, motor region)|interpro:IPR010926(Myosin tail 2)|interpro:IPR027417|interpro:IPR036072|interpro:IPR036961 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:5uvsgAipzkqnIHoUbjFfGR9vHS09606 rogid:bhf5eHUPewO2TgW7MWGTtjOEEAo9606 intact-crc:D787D8264DC9F4C7|rigid:WGC9ejC4CBnQUHLmKbKnYJSEJNo false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y2K6 uniprotkb:Q3KQU3 intact:EBI-2511991|ensembl:ENSP00000313811|ensembl:ENSP00000351122|ensembl:ENSP00000361506|intact:EBI-28979612|uniprotkb:Q9UQN8|uniprotkb:Q8IXQ1|uniprotkb:Q9UQP0|uniprotkb:Q96LG5|uniprotkb:Q541F1 intact:EBI-713229|uniprotkb:Q9HBQ2|uniprotkb:Q8N905|uniprotkb:Q9ULN3|uniprotkb:Q7L8J5|uniprotkb:Q8TAK0|intact:EBI-2511981|intact:EBI-1056140|ensembl:ENSP00000362244|uniprotkb:Q9NW29|uniprotkb:D3DPS4 psi-mi:ubp20_human(display_long)|uniprotkb:USP20(gene name)|psi-mi:USP20(display_short)|uniprotkb:KIAA1003(gene name synonym)|uniprotkb:LSFR3A(gene name synonym)|uniprotkb:VDU2(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 20(gene name synonym)|uniprotkb:Deubiquitinating enzyme 20(gene name synonym)|uniprotkb:VHL-interacting deubiquitinating enzyme 2(gene name synonym)|uniprotkb:Ubiquitin thioesterase 20(gene name synonym) psi-mi:ma7d1_human(display_long)|uniprotkb:MAP7D1(gene name)|psi-mi:MAP7D1(display_short)|uniprotkb:KIAA1187(gene name synonym)|uniprotkb:PARCC1(gene name synonym)|uniprotkb:RPRC1(gene name synonym)|uniprotkb:Proline/arginine-rich coiled-coil domain-containing protein 1(gene name synonym)|uniprotkb:Arginine/proline-rich coiled-coil domain-containing protein 1(gene name synonym)|uniprotkb:PP2464(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512022|imex:IM-12079-70 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENST00000315480(transcript)|ensembl:ENST00000358355(transcript)|ensembl:ENST00000372429(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006897"(endocytosis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|ensembl:ENSG00000136878(gene)|interpro:IPR028889|interpro:IPR035927|interpro:IPR038765|mint:Q9Y2K6|rcsb pdb:6KCZ|reactome:R-HSA-5689880|refseq:XP_011516463.1|refseq:XP_011516464.1|ensembl:ENSP00000313811|ensembl:ENSP00000351122|ensembl:ENSP00000361506|refseq:NP_001008563.2|refseq:NP_001103773.2|refseq:NP_006667.3|refseq:XP_005251722.1 refseq:NP_001273294.1|refseq:NP_001273295.1|ensembl:ENSG00000116871(gene)|ensembl:ENST00000373151(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0015630"(microtubule cytoskeleton)|interpro:IPR008604(E-MAP-115)|mint:Q3KQU3|refseq:NP_060537.3 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:5uvsgAipzkqnIHoUbjFfGR9vHS09606 rogid:AEal3/uaJsdRBdmijI8nuthBD9k9606 intact-crc:D787D8264DC9F4C7|rigid:WGC9ejC4CBnQUHLmKbKnYJSEJNo false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y2K6 uniprotkb:Q8TD30 intact:EBI-2511991|ensembl:ENSP00000313811|ensembl:ENSP00000351122|ensembl:ENSP00000361506|intact:EBI-28979612|uniprotkb:Q9UQN8|uniprotkb:Q8IXQ1|uniprotkb:Q9UQP0|uniprotkb:Q96LG5|uniprotkb:Q541F1 intact:EBI-2512017|ensembl:ENSP00000345282|uniprotkb:Q8N9E2 psi-mi:ubp20_human(display_long)|uniprotkb:USP20(gene name)|psi-mi:USP20(display_short)|uniprotkb:KIAA1003(gene name synonym)|uniprotkb:LSFR3A(gene name synonym)|uniprotkb:VDU2(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 20(gene name synonym)|uniprotkb:Deubiquitinating enzyme 20(gene name synonym)|uniprotkb:VHL-interacting deubiquitinating enzyme 2(gene name synonym)|uniprotkb:Ubiquitin thioesterase 20(gene name synonym) psi-mi:alat2_human(display_long)|uniprotkb:GPT2(gene name)|psi-mi:GPT2(display_short)|uniprotkb:AAT2(gene name synonym)|uniprotkb:ALT2(gene name synonym)|uniprotkb:Glutamic--pyruvic transaminase 2(gene name synonym)|uniprotkb:Glutamate pyruvate transaminase 2(gene name synonym)|uniprotkb:Glutamic--alanine transaminase 2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512022|imex:IM-12079-70 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENST00000315480(transcript)|ensembl:ENST00000358355(transcript)|ensembl:ENST00000372429(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006897"(endocytosis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|ensembl:ENSG00000136878(gene)|interpro:IPR028889|interpro:IPR035927|interpro:IPR038765|mint:Q9Y2K6|rcsb pdb:6KCZ|reactome:R-HSA-5689880|refseq:XP_011516463.1|refseq:XP_011516464.1|ensembl:ENSP00000313811|ensembl:ENSP00000351122|ensembl:ENSP00000361506|refseq:NP_001008563.2|refseq:NP_001103773.2|refseq:NP_006667.3|refseq:XP_005251722.1 ensembl:ENSG00000166123(gene)|ensembl:ENST00000340124(transcript)|go:"GO:0004021"("L-alanine:2-oxoglutarate aminotransferase activity")|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006103"(2-oxoglutarate metabolic process)|go:"GO:0009058"(biosynthetic process)|go:"GO:0030170"(pyridoxal phosphate binding)|go:"GO:0042851"(L-alanine metabolic process)|go:"GO:0042853"(L-alanine catabolic process)|interpro:IPR004839(Aminotransferase, class I and II)|interpro:IPR015421(Pyridoxal phosphate-dependent transferase, major region, subdomain 1)|interpro:IPR015422(Pyridoxal phosphate-dependent transferase, major region, subdomain 2)|interpro:IPR015424(Pyridoxal phosphate-dependent transferase, major region)|rcsb pdb:3IHJ|reactome:R-HSA-8964540|refseq:NP_001135938.1|refseq:NP_597700.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:5uvsgAipzkqnIHoUbjFfGR9vHS09606 rogid:y1b6AvLMwS7WNYKP9r2gwU2BeR49606 intact-crc:D787D8264DC9F4C7|rigid:WGC9ejC4CBnQUHLmKbKnYJSEJNo false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y2K6 uniprotkb:Q9BY77 intact:EBI-2511991|ensembl:ENSP00000313811|ensembl:ENSP00000351122|ensembl:ENSP00000361506|intact:EBI-28979612|uniprotkb:Q9UQN8|uniprotkb:Q8IXQ1|uniprotkb:Q9UQP0|uniprotkb:Q96LG5|uniprotkb:Q541F1 intact:EBI-1776152|uniprotkb:Q5H972|uniprotkb:Q6PGN6|uniprotkb:Q7Z6Z0|uniprotkb:Q9NSP5|uniprotkb:Q9NSP6|uniprotkb:A8K6F8|uniprotkb:A8K6V9|uniprotkb:Q009A7|ensembl:ENSP00000252115 psi-mi:ubp20_human(display_long)|uniprotkb:USP20(gene name)|psi-mi:USP20(display_short)|uniprotkb:KIAA1003(gene name synonym)|uniprotkb:LSFR3A(gene name synonym)|uniprotkb:VDU2(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 20(gene name synonym)|uniprotkb:Deubiquitinating enzyme 20(gene name synonym)|uniprotkb:VHL-interacting deubiquitinating enzyme 2(gene name synonym)|uniprotkb:Ubiquitin thioesterase 20(gene name synonym) psi-mi:pdip3_human(display_long)|uniprotkb:POLDIP3(gene name)|psi-mi:POLDIP3(display_short)|uniprotkb:KIAA1649(gene name synonym)|uniprotkb:PDIP46(gene name synonym)|uniprotkb:46 kDa DNA polymerase delta interaction protein(gene name synonym)|uniprotkb:S6K1 Aly/REF-like target(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512022|imex:IM-12079-70 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENST00000315480(transcript)|ensembl:ENST00000358355(transcript)|ensembl:ENST00000372429(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006897"(endocytosis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|ensembl:ENSG00000136878(gene)|interpro:IPR028889|interpro:IPR035927|interpro:IPR038765|mint:Q9Y2K6|rcsb pdb:6KCZ|reactome:R-HSA-5689880|refseq:XP_011516463.1|refseq:XP_011516464.1|ensembl:ENSP00000313811|ensembl:ENSP00000351122|ensembl:ENSP00000361506|refseq:NP_001008563.2|refseq:NP_001103773.2|refseq:NP_006667.3|refseq:XP_005251722.1 refseq:NP_115687.2|refseq:NP_835237.1|ensembl:ENSG00000100227(gene)|ensembl:ENST00000252115(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016607"(nuclear speck)|go:"GO:0016973"("poly(A)+ mRNA export from nucleus")|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045727"(positive regulation of translation)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034784|interpro:IPR035979|mint:Q9BY77|reactome:R-HSA-159236|reactome:R-HSA-72187|reactome:R-HSA-73856 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:5uvsgAipzkqnIHoUbjFfGR9vHS09606 rogid:64+Bf4QpCDdKkZMMH/7afOnOKH09606 intact-crc:D787D8264DC9F4C7|rigid:WGC9ejC4CBnQUHLmKbKnYJSEJNo false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y2K6 uniprotkb:O95714 intact:EBI-2511991|ensembl:ENSP00000313811|ensembl:ENSP00000351122|ensembl:ENSP00000361506|intact:EBI-28979612|uniprotkb:Q9UQN8|uniprotkb:Q8IXQ1|uniprotkb:Q9UQP0|uniprotkb:Q96LG5|uniprotkb:Q541F1 intact:EBI-1058922|uniprotkb:Q86SV7|uniprotkb:Q86SV8|uniprotkb:Q86SV9|uniprotkb:Q86YY3|uniprotkb:Q86YY4|uniprotkb:Q86YY5|uniprotkb:Q86YY6|uniprotkb:Q86YY7|uniprotkb:Q86YY8|uniprotkb:Q86YY9|uniprotkb:Q86YZ0|uniprotkb:Q86YZ1|intact:EBI-1104961|intact:EBI-28977852|ensembl:ENSP00000261609 psi-mi:ubp20_human(display_long)|uniprotkb:USP20(gene name)|psi-mi:USP20(display_short)|uniprotkb:KIAA1003(gene name synonym)|uniprotkb:LSFR3A(gene name synonym)|uniprotkb:VDU2(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 20(gene name synonym)|uniprotkb:Deubiquitinating enzyme 20(gene name synonym)|uniprotkb:VHL-interacting deubiquitinating enzyme 2(gene name synonym)|uniprotkb:Ubiquitin thioesterase 20(gene name synonym) psi-mi:herc2_human(display_long)|uniprotkb:HERC2(gene name)|psi-mi:HERC2(display_short)|uniprotkb:HECT domain and RCC1-like domain-containing protein 2(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase HERC2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512022|imex:IM-12079-70 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENST00000315480(transcript)|ensembl:ENST00000358355(transcript)|ensembl:ENST00000372429(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006897"(endocytosis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|ensembl:ENSG00000136878(gene)|interpro:IPR028889|interpro:IPR035927|interpro:IPR038765|mint:Q9Y2K6|rcsb pdb:6KCZ|reactome:R-HSA-5689880|refseq:XP_011516463.1|refseq:XP_011516464.1|ensembl:ENSP00000313811|ensembl:ENSP00000351122|ensembl:ENSP00000361506|refseq:NP_001008563.2|refseq:NP_001103773.2|refseq:NP_006667.3|refseq:XP_005251722.1 ensembl:ENSP00000261609|refseq:NP_004658.3|ensembl:ENSG00000128731(gene)|ensembl:ENST00000261609(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006281"(DNA repair)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032183"(SUMO binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR000433(Zinc finger, ZZ-type)|interpro:IPR000569(HECT)|interpro:IPR001199(Cytochrome b5)|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR006624(Beta-propeller repeat TECPR)|interpro:IPR008979(Galactose-binding like)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR010606(Mib-herc2)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR021097|interpro:IPR035983|interpro:IPR036400|interpro:IPR037252|interpro:IPR037976|interpro:IPR041987|interpro:IPR043145|mint:O95714|rcsb pdb:2KEO|go:"GO:0031625"(ubiquitin protein ligase binding)|rcsb pdb:3KCI|rcsb pdb:4L1M|rcsb pdb:6WW4|reactome:R-HSA-3108214|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473|reactome:R-HSA-983168|rcsb pdb:6WW3|dip:DIP-37632N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:5uvsgAipzkqnIHoUbjFfGR9vHS09606 rogid:ejMTmb0F9pM7zfHbRscV1rIRgSw9606 intact-crc:D787D8264DC9F4C7|rigid:WGC9ejC4CBnQUHLmKbKnYJSEJNo false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y2K6 uniprotkb:Q99613 intact:EBI-2511991|ensembl:ENSP00000313811|ensembl:ENSP00000351122|ensembl:ENSP00000361506|intact:EBI-28979612|uniprotkb:Q9UQN8|uniprotkb:Q8IXQ1|uniprotkb:Q9UQP0|uniprotkb:Q96LG5|uniprotkb:Q541F1 intact:EBI-353741|uniprotkb:A8K7Z0|intact:EBI-2876652|uniprotkb:O00215|uniprotkb:Q9BW98|uniprotkb:B2RXG3|intact:EBI-11017021|ensembl:ENSP00000332604|ensembl:ENSP00000378953|ensembl:ENSP00000457418|ensembl:ENSP00000457963|uniprotkb:B4E1D5|uniprotkb:H3BRV0 psi-mi:ubp20_human(display_long)|uniprotkb:USP20(gene name)|psi-mi:USP20(display_short)|uniprotkb:KIAA1003(gene name synonym)|uniprotkb:LSFR3A(gene name synonym)|uniprotkb:VDU2(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 20(gene name synonym)|uniprotkb:Deubiquitinating enzyme 20(gene name synonym)|uniprotkb:VHL-interacting deubiquitinating enzyme 2(gene name synonym)|uniprotkb:Ubiquitin thioesterase 20(gene name synonym) psi-mi:eif3c_human(display_long)|uniprotkb:EIF3C(gene name)|psi-mi:EIF3C(display_short)|uniprotkb:EIF3S8(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 8(gene name synonym)|uniprotkb:eIF3 p110(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512022|imex:IM-12079-70 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENST00000315480(transcript)|ensembl:ENST00000358355(transcript)|ensembl:ENST00000372429(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006897"(endocytosis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|ensembl:ENSG00000136878(gene)|interpro:IPR028889|interpro:IPR035927|interpro:IPR038765|mint:Q9Y2K6|rcsb pdb:6KCZ|reactome:R-HSA-5689880|refseq:XP_011516463.1|refseq:XP_011516464.1|ensembl:ENSP00000313811|ensembl:ENSP00000351122|ensembl:ENSP00000361506|refseq:NP_001008563.2|refseq:NP_001103773.2|refseq:NP_006667.3|refseq:XP_005251722.1 refseq:NP_001032897.1|refseq:NP_001186071.1|refseq:NP_003743.1|refseq:NP_001273407.1|ensembl:ENSG00000184110(gene)|ensembl:ENST00000331666(transcript)|ensembl:ENST00000395587(transcript)|ensembl:ENST00000566501(transcript)|ensembl:ENST00000566866(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0043022"(ribosome binding)|go:"GO:0045727"(positive regulation of translation)|go:"GO:1902416"(positive regulation of mRNA binding)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR008905(Eukaryotic translation initiation factor 3 subunit 8, N-terminal)|interpro:IPR027516|interpro:IPR036388|interpro:IPR036390|mint:Q99613|rcsb pdb:3J8B|rcsb pdb:3J8C|rcsb pdb:6YBD|rcsb pdb:6YBW|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|refseq:NP_001254503.1|dip:DIP-32865N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:5uvsgAipzkqnIHoUbjFfGR9vHS09606 rogid:74XQwDW6yxVsob6wZNgfuBlB06M9606 intact-crc:D787D8264DC9F4C7|rigid:WGC9ejC4CBnQUHLmKbKnYJSEJNo false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UK80 uniprotkb:Q5H9R7 intact:EBI-373242|uniprotkb:Q9BTV1|uniprotkb:Q9NYN4|uniprotkb:Q5VTX0|uniprotkb:Q9HBS2|uniprotkb:Q59H60|uniprotkb:Q5BKT5|uniprotkb:Q5VTW9|ensembl:ENSP00000289865|ensembl:ENSP00000356981 intact:EBI-355498|uniprotkb:Q3B7I1|uniprotkb:Q7L4R8|uniprotkb:Q8N3B2|uniprotkb:Q96MB2|uniprotkb:Q9H2K5|uniprotkb:Q9H2K6|uniprotkb:Q9HCL4|uniprotkb:Q9NUY3|uniprotkb:Q3I4Y0|uniprotkb:Q3KR35|uniprotkb:Q68CR3|intact:EBI-28971860|ensembl:ENSP00000377389 psi-mi:ubp21_human(display_long)|uniprotkb:USP21(gene name)|psi-mi:USP21(display_short)|uniprotkb:USP23(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 21(gene name synonym)|uniprotkb:Deubiquitinating enzyme 21(gene name synonym)|uniprotkb:PP1490(orf name)|uniprotkb:Ubiquitin thioesterase 21(gene name synonym) psi-mi:pp6r3_human(display_long)|uniprotkb:PPP6R3(gene name)|psi-mi:PPP6R3(display_short)|uniprotkb:C11orf23(gene name synonym)|uniprotkb:KIAA1558(gene name synonym)|uniprotkb:PP6R3(gene name synonym)|uniprotkb:SAPL(gene name synonym)|uniprotkb:Sporulation-induced transcript 4-associated protein SAPL(gene name synonym)|uniprotkb:SAPS domain family member 3(gene name synonym)|uniprotkb:SAPS3(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512177|imex:IM-12079-20 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001014443.1|refseq:NP_036607.3|refseq:NP_001306777.1|ensembl:ENSG00000143258(gene)|ensembl:ENST00000289865(transcript)|ensembl:ENST00000368002(transcript)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008234"(cysteine-type peptidase activity)|go:"GO:0016578"(histone deubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019784"(NEDD8-specific protease activity)|go:"GO:0031175"(neuron projection development)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|rcsb pdb:2Y5B|rcsb pdb:3I3T|rcsb pdb:3MTN|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5689880|dip:DIP-31255N refseq:NP_001157632.1|refseq:NP_001157633.1|refseq:NP_001157634.1|refseq:NP_001157635.1|refseq:NP_001157636.1|refseq:NP_060782.2|ensembl:ENST00000265636|ensembl:ENSP00000265636|ensembl:ENSP00000377389|ensembl:ENST00000393801|ensembl:ENSP00000377390|ensembl:ENST00000524845|ensembl:ENSP00000431415|ensembl:ENST00000524904|ensembl:ENSP00000433058|ensembl:ENST00000529710|ensembl:ENSP00000437329|refseq:XP_011543442.1|refseq:XP_006718676.1|refseq:XP_006718677.1|refseq:XP_006718681.1|refseq:XP_006718687.1|refseq:XP_016873451.1|refseq:XP_016873452.1|refseq:XP_016873455.1|ensembl:ENSG00000110075(gene)|ensembl:ENST00000393800(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|interpro:IPR007587(SIT4 phosphatase-associated protein)|interpro:IPR016024(Armadillo-type fold)|mint:Q5H9R7|reactome:R-HSA-171319|reactome:R-HSA-204005 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:vNe3OahP+E4GG/D8j+NqReBSSiY9606 rogid:9hU14AmzYI9nORfchfMtLoyRecA9606 intact-crc:995D7C880F398498|rigid:kW2lHdL07P9nUuPAk5NKsqGPaNk false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UK80 uniprotkb:Q9BZI7 intact:EBI-373242|uniprotkb:Q9BTV1|uniprotkb:Q9NYN4|uniprotkb:Q5VTX0|uniprotkb:Q9HBS2|uniprotkb:Q59H60|uniprotkb:Q5BKT5|uniprotkb:Q5VTW9|ensembl:ENSP00000289865|ensembl:ENSP00000356981 intact:EBI-372780|uniprotkb:Q0VAK8|uniprotkb:Q9H1J0|uniprotkb:D3DWI3|uniprotkb:D3DWI4|ensembl:ENSP00000276201 psi-mi:ubp21_human(display_long)|uniprotkb:USP21(gene name)|psi-mi:USP21(display_short)|uniprotkb:USP23(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 21(gene name synonym)|uniprotkb:Deubiquitinating enzyme 21(gene name synonym)|uniprotkb:PP1490(orf name)|uniprotkb:Ubiquitin thioesterase 21(gene name synonym) psi-mi:ren3b_human(display_long)|uniprotkb:RENT3B(gene name synonym)|uniprotkb:Nonsense mRNA reducing factor 3B(gene name synonym)|uniprotkb:Up-frameshift suppressor 3 homolog B(gene name synonym)|uniprotkb:UPF3X(gene name synonym)|uniprotkb:UPF3B(gene name)|psi-mi:UPF3B(display_short)|uniprotkb:Up-frameshift suppressor 3 homolog on chromosome X(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512177|imex:IM-12079-20 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001014443.1|refseq:NP_036607.3|refseq:NP_001306777.1|ensembl:ENSG00000143258(gene)|ensembl:ENST00000289865(transcript)|ensembl:ENST00000368002(transcript)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008234"(cysteine-type peptidase activity)|go:"GO:0016578"(histone deubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019784"(NEDD8-specific protease activity)|go:"GO:0031175"(neuron projection development)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|rcsb pdb:2Y5B|rcsb pdb:3I3T|rcsb pdb:3MTN|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5689880|dip:DIP-31255N refseq:NP_075386.1|refseq:NP_542199.1|ensembl:ENSG00000125351(gene)|ensembl:ENST00000276201(transcript)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0017056"(structural constituent of nuclear pore)|go:"GO:0034451"(centriolar satellite)|go:"GO:0035145"(exon-exon junction complex)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0051028"(mRNA transport)|interpro:IPR005120(Nonsense-mediated decay UPF3)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034979|interpro:IPR035979|interpro:IPR039722|rcsb pdb:1UW4|rcsb pdb:2XB2|reactome:R-HSA-159236|reactome:R-HSA-72163|reactome:R-HSA-72187|reactome:R-HSA-73856|reactome:R-HSA-9010553|reactome:R-HSA-975957|dip:DIP-31143N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:vNe3OahP+E4GG/D8j+NqReBSSiY9606 rogid:Gb7+eHYaODU5NxYLJC38bT2dOpw9606 intact-crc:995D7C880F398498|rigid:kW2lHdL07P9nUuPAk5NKsqGPaNk false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UK80 uniprotkb:P27448 intact:EBI-373242|uniprotkb:Q9BTV1|uniprotkb:Q9NYN4|uniprotkb:Q5VTX0|uniprotkb:Q9HBS2|uniprotkb:Q59H60|uniprotkb:Q5BKT5|uniprotkb:Q5VTW9|ensembl:ENSP00000289865|ensembl:ENSP00000356981 intact:EBI-707595|uniprotkb:O60219|uniprotkb:Q8TB41|uniprotkb:Q8WX83|uniprotkb:Q96RG1|uniprotkb:Q9UMY9|uniprotkb:Q9UN34|uniprotkb:Q86TT8|uniprotkb:A0A0A0MQR8|uniprotkb:A0A0A0MST9|uniprotkb:A0A0A0MT23|ensembl:ENSP00000411397 psi-mi:ubp21_human(display_long)|uniprotkb:USP21(gene name)|psi-mi:USP21(display_short)|uniprotkb:USP23(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 21(gene name synonym)|uniprotkb:Deubiquitinating enzyme 21(gene name synonym)|uniprotkb:PP1490(orf name)|uniprotkb:Ubiquitin thioesterase 21(gene name synonym) psi-mi:mark3_human(display_long)|uniprotkb:Cdc25C-associated protein kinase 1(gene name synonym)|uniprotkb:C-TAK1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase p78(gene name synonym)|uniprotkb:Ser/Thr protein kinase PAR-1(gene name synonym)|uniprotkb:Protein kinase STK10(gene name synonym)|uniprotkb:MARK3(gene name)|psi-mi:MARK3(display_short)|uniprotkb:CTAK1(gene name synonym)|uniprotkb:EMK2(gene name synonym)|uniprotkb:ELKL motif kinase 2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512177|imex:IM-12079-20 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001014443.1|refseq:NP_036607.3|refseq:NP_001306777.1|ensembl:ENSG00000143258(gene)|ensembl:ENST00000289865(transcript)|ensembl:ENST00000368002(transcript)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008234"(cysteine-type peptidase activity)|go:"GO:0016578"(histone deubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019784"(NEDD8-specific protease activity)|go:"GO:0031175"(neuron projection development)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|rcsb pdb:2Y5B|rcsb pdb:3I3T|rcsb pdb:3MTN|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5689880|dip:DIP-31255N refseq:NP_001122390.2|refseq:NP_001122391.2|refseq:NP_001122392.2|refseq:NP_001122393.2|refseq:NP_002367.5|dip:DIP-34637N|ensembl:ENSG00000075413(gene)|ensembl:ENST00000429436(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030425"(dendrite)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0035331"(negative regulation of hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036289"(peptidyl-serine autophosphorylation)|go:"GO:0048156"(tau protein binding)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001772(Kinase-associated KA1)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028375|interpro:IPR033628|mint:P27448|rcsb pdb:2QNJ|rcsb pdb:3FE3|rcsb pdb:7O94|reactome:R-HSA-5673000|reactome:R-HSA-5674135|reactome:R-HSA-5675221|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-9649948|reactome:R-HSA-9656223 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:vNe3OahP+E4GG/D8j+NqReBSSiY9606 rogid:YoMdp32OqT0OCgUUBwxSEHmA+vs9606 intact-crc:995D7C880F398498|rigid:kW2lHdL07P9nUuPAk5NKsqGPaNk false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UK80 uniprotkb:Q9Y2K6 intact:EBI-373242|uniprotkb:Q9BTV1|uniprotkb:Q9NYN4|uniprotkb:Q5VTX0|uniprotkb:Q9HBS2|uniprotkb:Q59H60|uniprotkb:Q5BKT5|uniprotkb:Q5VTW9|ensembl:ENSP00000289865|ensembl:ENSP00000356981 intact:EBI-2511991|ensembl:ENSP00000313811|ensembl:ENSP00000351122|ensembl:ENSP00000361506|intact:EBI-28979612|uniprotkb:Q9UQN8|uniprotkb:Q8IXQ1|uniprotkb:Q9UQP0|uniprotkb:Q96LG5|uniprotkb:Q541F1 psi-mi:ubp21_human(display_long)|uniprotkb:USP21(gene name)|psi-mi:USP21(display_short)|uniprotkb:USP23(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 21(gene name synonym)|uniprotkb:Deubiquitinating enzyme 21(gene name synonym)|uniprotkb:PP1490(orf name)|uniprotkb:Ubiquitin thioesterase 21(gene name synonym) psi-mi:ubp20_human(display_long)|uniprotkb:USP20(gene name)|psi-mi:USP20(display_short)|uniprotkb:KIAA1003(gene name synonym)|uniprotkb:LSFR3A(gene name synonym)|uniprotkb:VDU2(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 20(gene name synonym)|uniprotkb:Deubiquitinating enzyme 20(gene name synonym)|uniprotkb:VHL-interacting deubiquitinating enzyme 2(gene name synonym)|uniprotkb:Ubiquitin thioesterase 20(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512177|imex:IM-12079-20 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001014443.1|refseq:NP_036607.3|refseq:NP_001306777.1|ensembl:ENSG00000143258(gene)|ensembl:ENST00000289865(transcript)|ensembl:ENST00000368002(transcript)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008234"(cysteine-type peptidase activity)|go:"GO:0016578"(histone deubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019784"(NEDD8-specific protease activity)|go:"GO:0031175"(neuron projection development)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|rcsb pdb:2Y5B|rcsb pdb:3I3T|rcsb pdb:3MTN|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5689880|dip:DIP-31255N ensembl:ENST00000315480(transcript)|ensembl:ENST00000358355(transcript)|ensembl:ENST00000372429(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006897"(endocytosis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|ensembl:ENSG00000136878(gene)|interpro:IPR028889|interpro:IPR035927|interpro:IPR038765|mint:Q9Y2K6|rcsb pdb:6KCZ|reactome:R-HSA-5689880|refseq:XP_011516463.1|refseq:XP_011516464.1|ensembl:ENSP00000313811|ensembl:ENSP00000351122|ensembl:ENSP00000361506|refseq:NP_001008563.2|refseq:NP_001103773.2|refseq:NP_006667.3|refseq:XP_005251722.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:vNe3OahP+E4GG/D8j+NqReBSSiY9606 rogid:5uvsgAipzkqnIHoUbjFfGR9vHS09606 intact-crc:995D7C880F398498|rigid:kW2lHdL07P9nUuPAk5NKsqGPaNk false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UK80 uniprotkb:Q5T5X7 intact:EBI-373242|uniprotkb:Q9BTV1|uniprotkb:Q9NYN4|uniprotkb:Q5VTX0|uniprotkb:Q9HBS2|uniprotkb:Q59H60|uniprotkb:Q5BKT5|uniprotkb:Q5VTW9|ensembl:ENSP00000289865|ensembl:ENSP00000356981 intact:EBI-1211496|uniprotkb:A2RRH2|uniprotkb:Q9HCL9|ensembl:ENSP00000358038|ensembl:ENSP00000411268 psi-mi:ubp21_human(display_long)|uniprotkb:USP21(gene name)|psi-mi:USP21(display_short)|uniprotkb:USP23(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 21(gene name synonym)|uniprotkb:Deubiquitinating enzyme 21(gene name synonym)|uniprotkb:PP1490(orf name)|uniprotkb:Ubiquitin thioesterase 21(gene name synonym) psi-mi:bend3_human(display_long)|uniprotkb:BEND3(gene name)|psi-mi:BEND3(display_short)|uniprotkb:KIAA1553(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512177|imex:IM-12079-20 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001014443.1|refseq:NP_036607.3|refseq:NP_001306777.1|ensembl:ENSG00000143258(gene)|ensembl:ENST00000289865(transcript)|ensembl:ENST00000368002(transcript)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008234"(cysteine-type peptidase activity)|go:"GO:0016578"(histone deubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019784"(NEDD8-specific protease activity)|go:"GO:0031175"(neuron projection development)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|rcsb pdb:2Y5B|rcsb pdb:3I3T|rcsb pdb:3MTN|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5689880|dip:DIP-31255N refseq:XP_005267136.1|refseq:XP_005267137.1|refseq:NP_001073919.1|refseq:XP_011534307.1|refseq:XP_016866627.1|ensembl:ENSG00000178409(gene)|ensembl:ENST00000369042(transcript)|ensembl:ENST00000429433(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000182"(rDNA binding)|go:"GO:0000183"(rDNA heterochromatin assembly)|go:"GO:0000792"(heterochromatin)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006306"(DNA methylation)|go:"GO:0034773"(histone H4-K20 trimethylation)|go:"GO:0036124"(histone H3-K9 trimethylation)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0080182"(histone H3-K4 trimethylation)|go:"GO:0098532"(histone H3-K27 trimethylation)|go:"GO:1903580"(positive regulation of ATP metabolic process)|interpro:IPR018379|interpro:IPR033583|rcsb pdb:5JNO psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:vNe3OahP+E4GG/D8j+NqReBSSiY9606 rogid:W+UmsinDpvnD5wV9MZI5YWywK6U9606 intact-crc:995D7C880F398498|rigid:kW2lHdL07P9nUuPAk5NKsqGPaNk false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UK80 uniprotkb:Q9Y5S9 intact:EBI-373242|uniprotkb:Q9BTV1|uniprotkb:Q9NYN4|uniprotkb:Q5VTX0|uniprotkb:Q9HBS2|uniprotkb:Q59H60|uniprotkb:Q5BKT5|uniprotkb:Q5VTW9|ensembl:ENSP00000289865|ensembl:ENSP00000356981 intact:EBI-447231|uniprotkb:Q6FHD1|uniprotkb:Q6IQ40|uniprotkb:Q9GZX8|uniprotkb:Q9NZI4|uniprotkb:B3KQI9|intact:EBI-28979675|ensembl:ENSP00000463058|ensembl:ENSP00000488265 psi-mi:ubp21_human(display_long)|uniprotkb:USP21(gene name)|psi-mi:USP21(display_short)|uniprotkb:USP23(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 21(gene name synonym)|uniprotkb:Deubiquitinating enzyme 21(gene name synonym)|uniprotkb:PP1490(orf name)|uniprotkb:Ubiquitin thioesterase 21(gene name synonym) psi-mi:rbm8a_human(display_long)|uniprotkb:HSPC114(orf name)|uniprotkb:MDS014(orf name)|uniprotkb:RNA-binding motif protein 8A(gene name synonym)|uniprotkb:Ribonucleoprotein RBM8A(gene name synonym)|uniprotkb:RNA-binding protein Y14(gene name synonym)|uniprotkb:Binder of OVCA1-1(gene name synonym)|uniprotkb:RBM8A(gene name)|psi-mi:RBM8A(display_short)|uniprotkb:RBM8(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512177|imex:IM-12079-20 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001014443.1|refseq:NP_036607.3|refseq:NP_001306777.1|ensembl:ENSG00000143258(gene)|ensembl:ENST00000289865(transcript)|ensembl:ENST00000368002(transcript)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008234"(cysteine-type peptidase activity)|go:"GO:0016578"(histone deubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019784"(NEDD8-specific protease activity)|go:"GO:0031175"(neuron projection development)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|rcsb pdb:2Y5B|rcsb pdb:3I3T|rcsb pdb:3MTN|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5689880|dip:DIP-31255N refseq:NP_005096.1|ensembl:ENST00000369307|ensembl:ENSP00000358313|ensembl:ENSP00000463058|ensembl:ENSP00000488265|dip:DIP-33070N|ensembl:ENSG00000265241(gene)|ensembl:ENST00000583313(transcript)|ensembl:ENST00000632555(transcript)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006417"(regulation of translation)|go:"GO:0008380"(RNA splicing)|go:"GO:0016607"(nuclear speck)|go:"GO:0030425"(dendrite)|go:"GO:0035145"(exon-exon junction complex)|go:"GO:0043025"(neuronal cell body)|go:"GO:0051028"(mRNA transport)|go:"GO:0071006"(U2-type catalytic step 1 spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR008111(RNA binding motif protein 8)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR033744|interpro:IPR035979|mint:Q9Y5S9|rcsb pdb:1P27|rcsb pdb:2HYI|rcsb pdb:2J0Q|rcsb pdb:2J0S|rcsb pdb:2XB2|rcsb pdb:3EX7|rcsb pdb:5XJC|rcsb pdb:5YZG|rcsb pdb:6ICZ|rcsb pdb:6QDV|rcsb pdb:7A5P|reactome:R-HSA-159236|reactome:R-HSA-72163|reactome:R-HSA-72187|reactome:R-HSA-73856|reactome:R-HSA-9010553|reactome:R-HSA-975957 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:vNe3OahP+E4GG/D8j+NqReBSSiY9606 rogid:7WdTcDs4RqjiKDSkHF0fFD8rAb09606 intact-crc:995D7C880F398498|rigid:kW2lHdL07P9nUuPAk5NKsqGPaNk false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UK80 uniprotkb:Q9P0L2 intact:EBI-373242|uniprotkb:Q9BTV1|uniprotkb:Q9NYN4|uniprotkb:Q5VTX0|uniprotkb:Q9HBS2|uniprotkb:Q59H60|uniprotkb:Q5BKT5|uniprotkb:Q5VTW9|ensembl:ENSP00000289865|ensembl:ENSP00000356981 intact:EBI-968587|uniprotkb:Q2HIY1|uniprotkb:Q5VTF9|uniprotkb:Q5VTG0|uniprotkb:Q96SW9|uniprotkb:Q9P251|uniprotkb:D3DTB0|uniprotkb:D3DTB1|ensembl:ENSP00000355884 psi-mi:ubp21_human(display_long)|uniprotkb:USP21(gene name)|psi-mi:USP21(display_short)|uniprotkb:USP23(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 21(gene name synonym)|uniprotkb:Deubiquitinating enzyme 21(gene name synonym)|uniprotkb:PP1490(orf name)|uniprotkb:Ubiquitin thioesterase 21(gene name synonym) psi-mi:mark1_human(display_long)|uniprotkb:MARK1(gene name)|psi-mi:MARK1(display_short)|uniprotkb:KIAA1477(gene name synonym)|uniprotkb:MARK(gene name synonym)|uniprotkb:MAP/microtubule affinity-regulating kinase 1(gene name synonym)|uniprotkb:PAR1 homolog c(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512177|imex:IM-12079-20 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001014443.1|refseq:NP_036607.3|refseq:NP_001306777.1|ensembl:ENSG00000143258(gene)|ensembl:ENST00000289865(transcript)|ensembl:ENST00000368002(transcript)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008234"(cysteine-type peptidase activity)|go:"GO:0016578"(histone deubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019784"(NEDD8-specific protease activity)|go:"GO:0031175"(neuron projection development)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|rcsb pdb:2Y5B|rcsb pdb:3I3T|rcsb pdb:3MTN|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5689880|dip:DIP-31255N refseq:NP_001273057.1|refseq:NP_061120.3|ensembl:ENSP00000355884|ensembl:ENST00000366918|ensembl:ENSP00000355885|dip:DIP-39777N|ensembl:ENSG00000116141(gene)|ensembl:ENST00000366917(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001764"(neuron migration)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030425"(dendrite)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0048156"(tau protein binding)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0051654"(establishment of mitochondrion localization)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001772(Kinase-associated KA1)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028375|interpro:IPR033627|mint:Q9P0L2|rcsb pdb:2HAK|rcsb pdb:3OSE|rcsb pdb:6C9D psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:vNe3OahP+E4GG/D8j+NqReBSSiY9606 rogid:/ydFAiGjuUcmwDHO4tEPSSMlVjY9606 intact-crc:995D7C880F398498|rigid:kW2lHdL07P9nUuPAk5NKsqGPaNk false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UK80 uniprotkb:Q7KZI7 intact:EBI-373242|uniprotkb:Q9BTV1|uniprotkb:Q9NYN4|uniprotkb:Q5VTX0|uniprotkb:Q9HBS2|uniprotkb:Q59H60|uniprotkb:Q5BKT5|uniprotkb:Q5VTW9|ensembl:ENSP00000289865|ensembl:ENSP00000356981 intact:EBI-516560|uniprotkb:Q15449|uniprotkb:Q15524|uniprotkb:Q5XGA3|uniprotkb:Q68A18|uniprotkb:Q96HB3|uniprotkb:Q96RG0|ensembl:ENSP00000385751 psi-mi:ubp21_human(display_long)|uniprotkb:USP21(gene name)|psi-mi:USP21(display_short)|uniprotkb:USP23(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 21(gene name synonym)|uniprotkb:Deubiquitinating enzyme 21(gene name synonym)|uniprotkb:PP1490(orf name)|uniprotkb:Ubiquitin thioesterase 21(gene name synonym) psi-mi:mark2_human(display_long)|uniprotkb:MAP/microtubule affinity-regulating kinase 2(gene name synonym)|uniprotkb:ELKL motif kinase 1(gene name synonym)|uniprotkb:PAR1 homolog(gene name synonym)|uniprotkb:MARK2(gene name)|psi-mi:MARK2(display_short)|uniprotkb:EMK1(gene name synonym)|uniprotkb:PAR1 homolog b(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512177|imex:IM-12079-20 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001014443.1|refseq:NP_036607.3|refseq:NP_001306777.1|ensembl:ENSG00000143258(gene)|ensembl:ENST00000289865(transcript)|ensembl:ENST00000368002(transcript)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008234"(cysteine-type peptidase activity)|go:"GO:0016578"(histone deubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019784"(NEDD8-specific protease activity)|go:"GO:0031175"(neuron projection development)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|rcsb pdb:2Y5B|rcsb pdb:3I3T|rcsb pdb:3MTN|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5689880|dip:DIP-31255N refseq:NP_001034558.2|refseq:NP_001156768.1|refseq:NP_001156769.1|refseq:NP_004945.4|refseq:NP_059672.2|dip:DIP-31321N|ensembl:ENSG00000072518(gene)|ensembl:ENST00000402010(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0001764"(neuron migration)|go:"GO:0003723"(RNA binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008289"(lipid binding)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0045296"(cadherin binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048156"(tau protein binding)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030425"(dendrite)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0051646"(mitochondrion localization)|go:"GO:0061564"(axon development)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0071963"(establishment or maintenance of cell polarity regulating cell shape)|go:"GO:0097427"(microtubule bundle)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1904526"(regulation of microtubule binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001772(Kinase-associated KA1)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028375|mint:Q7KZI7|rcsb pdb:3IEC|rcsb pdb:5EAK|rcsb pdb:5KZ7|rcsb pdb:5KZ8 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:vNe3OahP+E4GG/D8j+NqReBSSiY9606 rogid:yfUqSCu4bgkncBd6hRRg5pKkArc9606 intact-crc:995D7C880F398498|rigid:kW2lHdL07P9nUuPAk5NKsqGPaNk false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UK80 uniprotkb:O75271 intact:EBI-373242|uniprotkb:Q9BTV1|uniprotkb:Q9NYN4|uniprotkb:Q5VTX0|uniprotkb:Q9HBS2|uniprotkb:Q59H60|uniprotkb:Q5BKT5|uniprotkb:Q5VTW9|ensembl:ENSP00000289865|ensembl:ENSP00000356981 intact:EBI-2512144 psi-mi:ubp21_human(display_long)|uniprotkb:USP21(gene name)|psi-mi:USP21(display_short)|uniprotkb:USP23(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 21(gene name synonym)|uniprotkb:Deubiquitinating enzyme 21(gene name synonym)|uniprotkb:PP1490(orf name)|uniprotkb:Ubiquitin thioesterase 21(gene name synonym) psi-mi:o75271_human(display_long) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512177|imex:IM-12079-20 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001014443.1|refseq:NP_036607.3|refseq:NP_001306777.1|ensembl:ENSG00000143258(gene)|ensembl:ENST00000289865(transcript)|ensembl:ENST00000368002(transcript)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008234"(cysteine-type peptidase activity)|go:"GO:0016578"(histone deubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019784"(NEDD8-specific protease activity)|go:"GO:0031175"(neuron projection development)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|rcsb pdb:2Y5B|rcsb pdb:3I3T|rcsb pdb:3MTN|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5689880|dip:DIP-31255N go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote) psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:vNe3OahP+E4GG/D8j+NqReBSSiY9606 rogid:KUEiJMN0cWYUN+uYdGWh2WZQw4g9606 intact-crc:995D7C880F398498|rigid:kW2lHdL07P9nUuPAk5NKsqGPaNk false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UK80 uniprotkb:O15084 intact:EBI-373242|uniprotkb:Q9BTV1|uniprotkb:Q9NYN4|uniprotkb:Q5VTX0|uniprotkb:Q9HBS2|uniprotkb:Q59H60|uniprotkb:Q5BKT5|uniprotkb:Q5VTW9|ensembl:ENSP00000289865|ensembl:ENSP00000356981 intact:EBI-359567|uniprotkb:Q6ULS0|uniprotkb:Q6ZT57|uniprotkb:B4DES5|uniprotkb:Q1WWL4|uniprotkb:Q29RW6|uniprotkb:Q3B857|ensembl:ENSP00000382379|ensembl:ENSP00000397341 psi-mi:ubp21_human(display_long)|uniprotkb:USP21(gene name)|psi-mi:USP21(display_short)|uniprotkb:USP23(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 21(gene name synonym)|uniprotkb:Deubiquitinating enzyme 21(gene name synonym)|uniprotkb:PP1490(orf name)|uniprotkb:Ubiquitin thioesterase 21(gene name synonym) psi-mi:anr28_human(display_long)|uniprotkb:ANKRD28(gene name)|psi-mi:ANKRD28(display_short)|uniprotkb:KIAA0379(gene name synonym)|uniprotkb:Ankyrin repeat domain-containing protein 28(gene name synonym)|uniprotkb:Phosphatase interactor targeting protein hnRNP K(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512177|imex:IM-12079-20 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001014443.1|refseq:NP_036607.3|refseq:NP_001306777.1|ensembl:ENSG00000143258(gene)|ensembl:ENST00000289865(transcript)|ensembl:ENST00000368002(transcript)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008234"(cysteine-type peptidase activity)|go:"GO:0016578"(histone deubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019784"(NEDD8-specific protease activity)|go:"GO:0031175"(neuron projection development)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|rcsb pdb:2Y5B|rcsb pdb:3I3T|rcsb pdb:3MTN|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5689880|dip:DIP-31255N refseq:NP_001182027.1|refseq:NP_001182028.1|refseq:NP_056014.2|refseq:XP_011531842.1|refseq:XP_005265053.1|refseq:XP_016861515.1|refseq:XP_016861516.1|dip:DIP-27583N|ensembl:ENSG00000206560(gene)|ensembl:ENST00000399451(transcript)|ensembl:ENST00000412318(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR036770|mint:O15084|reactome:R-HSA-171319|reactome:R-HSA-204005 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:vNe3OahP+E4GG/D8j+NqReBSSiY9606 rogid:YLJtZR7PWrGejJ8EFI093KRtb2Q9606 intact-crc:995D7C880F398498|rigid:kW2lHdL07P9nUuPAk5NKsqGPaNk false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UK80 uniprotkb:P41743 intact:EBI-373242|uniprotkb:Q9BTV1|uniprotkb:Q9NYN4|uniprotkb:Q5VTX0|uniprotkb:Q9HBS2|uniprotkb:Q59H60|uniprotkb:Q5BKT5|uniprotkb:Q5VTW9|ensembl:ENSP00000289865|ensembl:ENSP00000356981 intact:EBI-286199|uniprotkb:Q8WW06|uniprotkb:D3DNQ4|ensembl:ENSP00000295797 psi-mi:ubp21_human(display_long)|uniprotkb:USP21(gene name)|psi-mi:USP21(display_short)|uniprotkb:USP23(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 21(gene name synonym)|uniprotkb:Deubiquitinating enzyme 21(gene name synonym)|uniprotkb:PP1490(orf name)|uniprotkb:Ubiquitin thioesterase 21(gene name synonym) psi-mi:kpci_human(display_long)|uniprotkb:nPKC-iota(gene name synonym)|uniprotkb:Atypical protein kinase C-lambda/iota(gene name synonym)|uniprotkb:PRKCI(gene name)|psi-mi:PRKCI(display_short)|uniprotkb:DXS1179E(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512177|imex:IM-12079-20 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001014443.1|refseq:NP_036607.3|refseq:NP_001306777.1|ensembl:ENSG00000143258(gene)|ensembl:ENST00000289865(transcript)|ensembl:ENST00000368002(transcript)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008234"(cysteine-type peptidase activity)|go:"GO:0016578"(histone deubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019784"(NEDD8-specific protease activity)|go:"GO:0031175"(neuron projection development)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|rcsb pdb:2Y5B|rcsb pdb:3I3T|rcsb pdb:3MTN|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5689880|dip:DIP-31255N refseq:NP_002731.4|dip:DIP-31311N|ensembl:ENSG00000163558(gene)|ensembl:ENST00000295797(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004697"(protein kinase C activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007015"(actin filament organization)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016477"(cell migration)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0031252"(cell leading edge)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0035089"(establishment of apical/basal cell polarity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042462"(eye photoreceptor cell development)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043220"(Schmidt-Lanterman incisure)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045171"(intercellular bridge)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046872"(metal ion binding)|go:"GO:0046903"(secretion)|go:"GO:0048194"(Golgi vesicle budding)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0061024"(membrane organization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099072"(regulation of postsynaptic membrane neurotransmitter receptor levels)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012233(Protein kinase C, zeta/iota)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR020454|interpro:IPR034661|interpro:IPR034877|mint:P41743|rcsb pdb:1VD2|rcsb pdb:1WMH|rcsb pdb:1ZRZ|rcsb pdb:3A8W|rcsb pdb:3A8X|rcsb pdb:3ZH8|rcsb pdb:5LI1|rcsb pdb:5LI9|rcsb pdb:5LIH|rcsb pdb:6ILZ|reactome:R-HSA-1912408|reactome:R-HSA-209543|reactome:R-HSA-420029 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:vNe3OahP+E4GG/D8j+NqReBSSiY9606 rogid:v8sZdKjtlBejk0MH/9gwOjRqy+49606 intact-crc:995D7C880F398498|rigid:kW2lHdL07P9nUuPAk5NKsqGPaNk false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UK80 uniprotkb:Q8IUH3 intact:EBI-373242|uniprotkb:Q9BTV1|uniprotkb:Q9NYN4|uniprotkb:Q5VTX0|uniprotkb:Q9HBS2|uniprotkb:Q59H60|uniprotkb:Q5BKT5|uniprotkb:Q5VTW9|ensembl:ENSP00000289865|ensembl:ENSP00000356981 intact:EBI-2512147|ensembl:ENSP00000482083|uniprotkb:Q8NFC9|uniprotkb:Q6NYL0 psi-mi:ubp21_human(display_long)|uniprotkb:USP21(gene name)|psi-mi:USP21(display_short)|uniprotkb:USP23(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 21(gene name synonym)|uniprotkb:Deubiquitinating enzyme 21(gene name synonym)|uniprotkb:PP1490(orf name)|uniprotkb:Ubiquitin thioesterase 21(gene name synonym) psi-mi:rbm45_human(display_long)|uniprotkb:RBM45(gene name)|psi-mi:RBM45(display_short)|uniprotkb:DRB1(gene name synonym)|uniprotkb:DRBP1(gene name synonym)|uniprotkb:RNA-binding motif protein 45(gene name synonym)|uniprotkb:Developmentally-regulated RNA-binding protein 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512177|imex:IM-12079-20 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001014443.1|refseq:NP_036607.3|refseq:NP_001306777.1|ensembl:ENSG00000143258(gene)|ensembl:ENST00000289865(transcript)|ensembl:ENST00000368002(transcript)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008234"(cysteine-type peptidase activity)|go:"GO:0016578"(histone deubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019784"(NEDD8-specific protease activity)|go:"GO:0031175"(neuron projection development)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|rcsb pdb:2Y5B|rcsb pdb:3I3T|rcsb pdb:3MTN|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5689880|dip:DIP-31255N ensembl:ENSG00000155636(gene)|ensembl:ENST00000616198(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0007399"(nervous system development)|go:"GO:0030154"(cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR033101|interpro:IPR034203|interpro:IPR034206|interpro:IPR034207|interpro:IPR034208|interpro:IPR035979|mint:Q8IUH3|rcsb pdb:7CSX|rcsb pdb:7CSZ|go:"GO:0005634"(nucleus)|refseq:NP_694453.2|refseq:XP_005246344.1|refseq:XP_016858811.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:vNe3OahP+E4GG/D8j+NqReBSSiY9606 rogid:8w7mWJ1ncdOyq9VCGIIYK3qapxY9606 intact-crc:995D7C880F398498|rigid:kW2lHdL07P9nUuPAk5NKsqGPaNk false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UK80 uniprotkb:P23284 intact:EBI-373242|uniprotkb:Q9BTV1|uniprotkb:Q9NYN4|uniprotkb:Q5VTX0|uniprotkb:Q9HBS2|uniprotkb:Q59H60|uniprotkb:Q5BKT5|uniprotkb:Q5VTW9|ensembl:ENSP00000289865|ensembl:ENSP00000356981 intact:EBI-359252|uniprotkb:Q9BVK5|uniprotkb:A8K534|uniprotkb:Q6IBH5|ensembl:ENSP00000300026 psi-mi:ubp21_human(display_long)|uniprotkb:USP21(gene name)|psi-mi:USP21(display_short)|uniprotkb:USP23(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 21(gene name synonym)|uniprotkb:Deubiquitinating enzyme 21(gene name synonym)|uniprotkb:PP1490(orf name)|uniprotkb:Ubiquitin thioesterase 21(gene name synonym) psi-mi:ppib_human(display_long)|uniprotkb:PPIB(gene name)|psi-mi:PPIB(display_short)|uniprotkb:CYPB(gene name synonym)|uniprotkb:Cyclophilin B(gene name synonym)|uniprotkb:S-cyclophilin(gene name synonym)|uniprotkb:CYP-S1(gene name synonym)|uniprotkb:Rotamase B(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512177|imex:IM-12079-20 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001014443.1|refseq:NP_036607.3|refseq:NP_001306777.1|ensembl:ENSG00000143258(gene)|ensembl:ENST00000289865(transcript)|ensembl:ENST00000368002(transcript)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008234"(cysteine-type peptidase activity)|go:"GO:0016578"(histone deubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019784"(NEDD8-specific protease activity)|go:"GO:0031175"(neuron projection development)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|rcsb pdb:2Y5B|rcsb pdb:3I3T|rcsb pdb:3MTN|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5689880|dip:DIP-31255N refseq:NP_000933.1|ensembl:ENSG00000166794(gene)|ensembl:ENST00000300026(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003723"(RNA binding)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005925"(focal adhesion)|go:"GO:0006457"(protein folding)|go:"GO:0016018"(cyclosporin A binding)|go:"GO:0016020"(membrane)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034663"(endoplasmic reticulum chaperone complex)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042470"(melanosome)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044794"(positive regulation by host of viral process)|go:"GO:0044829"(positive regulation by host of viral genome replication)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0060348"(bone development)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070063"(RNA polymerase binding)|interpro:IPR002130(Peptidyl-prolyl cis-trans isomerase, cyclophilin-type)|interpro:IPR020892|interpro:IPR029000|mint:P23284|rcsb pdb:1CYN|rcsb pdb:3ICH|rcsb pdb:3ICI|reactome:R-HSA-1650814 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:vNe3OahP+E4GG/D8j+NqReBSSiY9606 rogid:h6nKaPUyEYUctYuu/3XfFhM4y9c9606 intact-crc:995D7C880F398498|rigid:kW2lHdL07P9nUuPAk5NKsqGPaNk false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UK80 uniprotkb:P09936 intact:EBI-373242|uniprotkb:Q9BTV1|uniprotkb:Q9NYN4|uniprotkb:Q5VTX0|uniprotkb:Q9HBS2|uniprotkb:Q59H60|uniprotkb:Q5BKT5|uniprotkb:Q5VTW9|ensembl:ENSP00000289865|ensembl:ENSP00000356981 intact:EBI-714860|uniprotkb:Q71UM0|intact:EBI-1049220|uniprotkb:Q4W5K6|ensembl:ENSP00000284440|ensembl:ENSP00000422542 psi-mi:ubp21_human(display_long)|uniprotkb:USP21(gene name)|psi-mi:USP21(display_short)|uniprotkb:USP23(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 21(gene name synonym)|uniprotkb:Deubiquitinating enzyme 21(gene name synonym)|uniprotkb:PP1490(orf name)|uniprotkb:Ubiquitin thioesterase 21(gene name synonym) psi-mi:uchl1_human(display_long)|uniprotkb:Ubiquitin thioesterase L1(gene name synonym)|uniprotkb:Neuron cytoplasmic protein 9.5(gene name synonym)|uniprotkb:PGP 9.5(gene name synonym)|uniprotkb:UCHL1(gene name)|psi-mi:UCHL1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512177|imex:IM-12079-20 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001014443.1|refseq:NP_036607.3|refseq:NP_001306777.1|ensembl:ENSG00000143258(gene)|ensembl:ENST00000289865(transcript)|ensembl:ENST00000368002(transcript)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008234"(cysteine-type peptidase activity)|go:"GO:0016578"(histone deubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019784"(NEDD8-specific protease activity)|go:"GO:0031175"(neuron projection development)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|rcsb pdb:2Y5B|rcsb pdb:3I3T|rcsb pdb:3MTN|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5689880|dip:DIP-31255N refseq:NP_004172.2|ensembl:ENSG00000154277(gene)|ensembl:ENST00000284440(transcript)|ensembl:ENST00000503431(transcript)|go:"GO:0002931"(response to ischemia)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0007412"(axon target recognition)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008242"(omega peptidase activity)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0016874"(ligase activity)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019896"(axonal transport of mitochondrion)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031694"(alpha-2A adrenergic receptor binding)|go:"GO:0035690"|go:"GO:0042755"(eating behavior)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0050905"(neuromuscular process)|go:"GO:1904115"(axon cytoplasm)|interpro:IPR001578(Peptidase C12, ubiquitin carboxyl-terminal hydrolase 1)|interpro:IPR030297|interpro:IPR036959|interpro:IPR038765|mint:P09936|rcsb pdb:2ETL|rcsb pdb:2LEN|rcsb pdb:3IFW|rcsb pdb:3IRT|rcsb pdb:3KVF|rcsb pdb:3KW5|rcsb pdb:4DM9|rcsb pdb:4JKJ|reactome:R-HSA-5689603|go:"GO:0055001"(muscle cell development)|dip:DIP-36620N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:vNe3OahP+E4GG/D8j+NqReBSSiY9606 rogid:bQ3cxdH+e5fTg7KZ1wjHcOd9cIs9606 intact-crc:995D7C880F398498|rigid:kW2lHdL07P9nUuPAk5NKsqGPaNk false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UK80 uniprotkb:P04066 intact:EBI-373242|uniprotkb:Q9BTV1|uniprotkb:Q9NYN4|uniprotkb:Q5VTX0|uniprotkb:Q9HBS2|uniprotkb:Q59H60|uniprotkb:Q5BKT5|uniprotkb:Q5VTW9|ensembl:ENSP00000289865|ensembl:ENSP00000356981 intact:EBI-2512153|ensembl:ENSP00000363603|uniprotkb:Q14335|uniprotkb:Q8NAC2|uniprotkb:Q3LID0|uniprotkb:Q14334|uniprotkb:B2RBG3 psi-mi:ubp21_human(display_long)|uniprotkb:USP21(gene name)|psi-mi:USP21(display_short)|uniprotkb:USP23(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 21(gene name synonym)|uniprotkb:Deubiquitinating enzyme 21(gene name synonym)|uniprotkb:PP1490(orf name)|uniprotkb:Ubiquitin thioesterase 21(gene name synonym) psi-mi:fuco_human(display_long)|uniprotkb:FUCA1(gene name)|psi-mi:FUCA1(display_short)|uniprotkb:Alpha-L-fucoside fucohydrolase 1(gene name synonym)|uniprotkb:Alpha-L-fucosidase I(gene name synonym)|uniprotkb:Nbla10230(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512177|imex:IM-12079-20 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001014443.1|refseq:NP_036607.3|refseq:NP_001306777.1|ensembl:ENSG00000143258(gene)|ensembl:ENST00000289865(transcript)|ensembl:ENST00000368002(transcript)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008234"(cysteine-type peptidase activity)|go:"GO:0016578"(histone deubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019784"(NEDD8-specific protease activity)|go:"GO:0031175"(neuron projection development)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|rcsb pdb:2Y5B|rcsb pdb:3I3T|rcsb pdb:3MTN|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5689880|dip:DIP-31255N ensembl:ENSG00000179163(gene)|ensembl:ENST00000374479(transcript)|go:"GO:0004560"(alpha-L-fucosidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0006004"(fucose metabolic process)|go:"GO:0006027"(glycosaminoglycan catabolic process)|go:"GO:0016139"(glycoside catabolic process)|go:"GO:0019377"(glycolipid catabolic process)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000933("Glycoside hydrolase, family 29 (alpha-L-fucosidase)")|interpro:IPR013780(Glycosyl hydrolase, family 13, all-beta)|interpro:IPR016286(Alpha-L-fucosidase)|interpro:IPR017853(Glycoside hydrolase, catalytic core)|interpro:IPR018526|interpro:IPR028755|interpro:IPR031919|mint:P04066|reactome:R-HSA-6798695|reactome:R-HSA-975578|refseq:NP_000138.2 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:vNe3OahP+E4GG/D8j+NqReBSSiY9606 rogid:hzGxBObvRAGMJxL+I9shJUo+nLg9606 intact-crc:995D7C880F398498|rigid:kW2lHdL07P9nUuPAk5NKsqGPaNk false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UK80 uniprotkb:Q86UV5 intact:EBI-373242|uniprotkb:Q9BTV1|uniprotkb:Q9NYN4|uniprotkb:Q5VTX0|uniprotkb:Q9HBS2|uniprotkb:Q59H60|uniprotkb:Q5BKT5|uniprotkb:Q5VTW9|ensembl:ENSP00000289865|ensembl:ENSP00000356981 intact:EBI-2512161|uniprotkb:Q2M3I4|uniprotkb:Q5SZI4|uniprotkb:Q96IQ3|uniprotkb:Q8N3F6|uniprotkb:Q9NUJ6|uniprotkb:Q9H5N3|uniprotkb:Q9H5T7|uniprotkb:Q96F64|uniprotkb:Q9NXR0|uniprotkb:Q6NX53|uniprotkb:Q5T3T5|intact:EBI-2512805|uniprotkb:B7ZKS7|ensembl:ENSP00000309262 psi-mi:ubp21_human(display_long)|uniprotkb:USP21(gene name)|psi-mi:USP21(display_short)|uniprotkb:USP23(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 21(gene name synonym)|uniprotkb:Deubiquitinating enzyme 21(gene name synonym)|uniprotkb:PP1490(orf name)|uniprotkb:Ubiquitin thioesterase 21(gene name synonym) psi-mi:ubp48_human(display_long)|uniprotkb:Ubiquitin-specific peptidase 48(gene name synonym)|uniprotkb:Ubiquitin-specific protease 48(gene name synonym)|uniprotkb:USP48(gene name)|psi-mi:USP48(display_short)|uniprotkb:USP31(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 48(gene name synonym)|uniprotkb:Deubiquitinating enzyme 48(gene name synonym)|uniprotkb:Ubiquitin thioesterase 48(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512177|imex:IM-12079-20 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001014443.1|refseq:NP_036607.3|refseq:NP_001306777.1|ensembl:ENSG00000143258(gene)|ensembl:ENST00000289865(transcript)|ensembl:ENST00000368002(transcript)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008234"(cysteine-type peptidase activity)|go:"GO:0016578"(histone deubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019784"(NEDD8-specific protease activity)|go:"GO:0031175"(neuron projection development)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|rcsb pdb:2Y5B|rcsb pdb:3I3T|rcsb pdb:3MTN|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5689880|dip:DIP-31255N refseq:NP_001027902.1|refseq:NP_115612.4|refseq:NP_001317323.1|ensembl:ENSG00000090686(gene)|ensembl:ENST00000308271(transcript)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|interpro:IPR000626(Ubiquitin)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR018200|interpro:IPR028889|interpro:IPR029071|interpro:IPR033841|interpro:IPR035927|interpro:IPR038765|interpro:IPR044743|reactome:R-HSA-5689880 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:vNe3OahP+E4GG/D8j+NqReBSSiY9606 rogid:isCDJibvxhTQ6G+bIdJ2/vsNSRY9606 intact-crc:995D7C880F398498|rigid:kW2lHdL07P9nUuPAk5NKsqGPaNk false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UK80 uniprotkb:P46939 intact:EBI-373242|uniprotkb:Q9BTV1|uniprotkb:Q9NYN4|uniprotkb:Q5VTX0|uniprotkb:Q9HBS2|uniprotkb:Q59H60|uniprotkb:Q5BKT5|uniprotkb:Q5VTW9|ensembl:ENSP00000289865|ensembl:ENSP00000356981 intact:EBI-295856|intact:EBI-784141|uniprotkb:Q5SZ57|uniprotkb:Q5SYY1|uniprotkb:Q9UJ40|ensembl:ENSP00000356515 psi-mi:ubp21_human(display_long)|uniprotkb:USP21(gene name)|psi-mi:USP21(display_short)|uniprotkb:USP23(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 21(gene name synonym)|uniprotkb:Deubiquitinating enzyme 21(gene name synonym)|uniprotkb:PP1490(orf name)|uniprotkb:Ubiquitin thioesterase 21(gene name synonym) psi-mi:utrn_human(display_long)|uniprotkb:UTRN(gene name)|psi-mi:UTRN(display_short)|uniprotkb:DMDL(gene name synonym)|uniprotkb:Dystrophin-related protein 1(gene name synonym)|uniprotkb:DRP1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512177|imex:IM-12079-20 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001014443.1|refseq:NP_036607.3|refseq:NP_001306777.1|ensembl:ENSG00000143258(gene)|ensembl:ENST00000289865(transcript)|ensembl:ENST00000368002(transcript)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008234"(cysteine-type peptidase activity)|go:"GO:0016578"(histone deubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019784"(NEDD8-specific protease activity)|go:"GO:0031175"(neuron projection development)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|rcsb pdb:2Y5B|rcsb pdb:3I3T|rcsb pdb:3MTN|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5689880|dip:DIP-31255N ensembl:ENSP00000356515|refseq:XP_011534408.1|refseq:NP_009055.2|refseq:XP_005267187.1|dip:DIP-711N|ensembl:ENSG00000152818(gene)|ensembl:ENST00000367545(transcript)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0003779"(actin binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006936"(muscle contraction)|go:"GO:0007517"(muscle organ development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016010"(dystrophin-associated glycoprotein complex)|go:"GO:0016020"(membrane)|go:"GO:0017166"(vinculin binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030175"(filopodium)|go:"GO:0031527"(filopodium membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042383"(sarcolemma)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:2000649"(regulation of sodium ion transmembrane transporter activity)|interpro:IPR000433(Zinc finger, ZZ-type)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR002017(Spectrin repeat)|interpro:IPR011992(EF-Hand type)|interpro:IPR015153(EF-hand, region 1)|interpro:IPR015154(EF-hand, region 2)|interpro:IPR018159|interpro:IPR035436|interpro:IPR036020|interpro:IPR036872|interpro:IPR043145|mint:P46939|rcsb pdb:1BHD|rcsb pdb:1QAG|rcsb pdb:6M5G|reactome:R-HSA-9619665 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:vNe3OahP+E4GG/D8j+NqReBSSiY9606 rogid:metWqbqGtzonNZ1mgNjlFrenuI89606 intact-crc:995D7C880F398498|rigid:kW2lHdL07P9nUuPAk5NKsqGPaNk false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UPT9 uniprotkb:Q2M1P5 intact:EBI-723510|ensembl:ENSP00000261497|uniprotkb:A0JNS3|uniprotkb:Q2NLE2|uniprotkb:Q6MZY4|uniprotkb:Q8TBS8|uniprotkb:Q96IW5 intact:EBI-2512228|ensembl:ENSP00000377934|uniprotkb:Q3SXY0|uniprotkb:Q6UXE9|uniprotkb:Q8IW72 psi-mi:ubp22_human(display_long)|uniprotkb:Ubiquitin-specific-processing protease 22(gene name synonym)|uniprotkb:Deubiquitinating enzyme 22(gene name synonym)|uniprotkb:USP22(gene name)|psi-mi:USP22(display_short)|uniprotkb:KIAA1063(gene name synonym)|uniprotkb:USP3L(gene name synonym)|uniprotkb:Ubiquitin thioesterase 22(gene name synonym) psi-mi:kif7_human(display_long)|uniprotkb:KIF7(gene name)|psi-mi:KIF7(display_short)|uniprotkb:UNQ340/PRO539(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512240|imex:IM-12079-71 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_056091.1|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|go:"GO:0007049"(cell cycle)|interpro:IPR028889|interpro:IPR038765|mint:Q9UPT9|go:"GO:0008270"(zinc ion binding)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|reactome:R-HSA-3214847|go:"GO:0016574"(histone ubiquitination)|go:"GO:0016578"(histone deubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019899"(enzyme binding)|reactome:R-HSA-5689880|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|ensembl:ENSG00000124422(gene)|ensembl:ENST00000261497(transcript)|go:"GO:0000124"(SAGA complex)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process) ensembl:ENSG00000166813(gene)|ensembl:ENST00000394412(transcript)|go:"GO:0003777"(microtubule motor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|go:"GO:0005929"(cilium)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0008017"(microtubule binding)|go:"GO:0036064"(ciliary basal body)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0097542"(ciliary tip)|go:"GO:1990939"|interpro:IPR001752(Kinesin, motor region)|interpro:IPR019821|interpro:IPR027417|interpro:IPR036961|mint:Q2M1P5|rcsb pdb:2XT3|rcsb pdb:4A14|rcsb pdb:6MLQ|rcsb pdb:6MLR|reactome:R-HSA-5610787|reactome:R-HSA-5632684|refseq:NP_940927.2 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:8n1lOTC7I8dP3RY1IEUtIkJiSXc9606 rogid:yEZWFId7u3KkCdclCbZNeAZS1B49606 intact-crc:46AE6105F20EC20E|rigid:G/EnPPzh4kUfo1qCim0ykCN+Qqw false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UPT9 uniprotkb:Q92830 intact:EBI-723510|ensembl:ENSP00000261497|uniprotkb:A0JNS3|uniprotkb:Q2NLE2|uniprotkb:Q6MZY4|uniprotkb:Q8TBS8|uniprotkb:Q96IW5 intact:EBI-477622|uniprotkb:Q9UCW1|uniprotkb:Q8N1A2|ensembl:ENSP00000225916 psi-mi:ubp22_human(display_long)|uniprotkb:Ubiquitin-specific-processing protease 22(gene name synonym)|uniprotkb:Deubiquitinating enzyme 22(gene name synonym)|uniprotkb:USP22(gene name)|psi-mi:USP22(display_short)|uniprotkb:KIAA1063(gene name synonym)|uniprotkb:USP3L(gene name synonym)|uniprotkb:Ubiquitin thioesterase 22(gene name synonym) psi-mi:kat2a_human(display_long)|uniprotkb:Histone acetyltransferase GCN5(gene name synonym)|uniprotkb:STAF97(gene name synonym)|uniprotkb:General control of amino acid synthesis protein 5-like 2(gene name synonym)|uniprotkb:GCN5L2(gene name synonym)|uniprotkb:Lysine acetyltransferase 2A(gene name synonym)|uniprotkb:KAT2A(gene name)|psi-mi:KAT2A(display_short)|uniprotkb:GCN5(gene name synonym)|uniprotkb:Histone succinyltransferase KAT2A(gene name synonym)|uniprotkb:Histone glutaryltransferase KAT2A(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512240|imex:IM-12079-71 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_056091.1|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|go:"GO:0007049"(cell cycle)|interpro:IPR028889|interpro:IPR038765|mint:Q9UPT9|go:"GO:0008270"(zinc ion binding)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|reactome:R-HSA-3214847|go:"GO:0016574"(histone ubiquitination)|go:"GO:0016578"(histone deubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019899"(enzyme binding)|reactome:R-HSA-5689880|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|ensembl:ENSG00000124422(gene)|ensembl:ENST00000261497(transcript)|go:"GO:0000124"(SAGA complex)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process) refseq:NP_066564.2|ensembl:ENSG00000108773(gene)|ensembl:ENST00000225916(transcript)|go:"GO:0000123"(histone acetyltransferase complex)|go:"GO:0000785"(chromatin)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001756"(somitogenesis)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001843"(neural tube closure)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004402"(histone acetyltransferase activity)|go:"GO:0045722"(positive regulation of gluconeogenesis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046600"(negative regulation of centriole replication)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048312"(intracellular distribution of mitochondria)|go:"GO:0050863"(regulation of T cell activation)|go:"GO:0060173"(limb development)|go:"GO:0061035"(regulation of cartilage development)|go:"GO:0061733"(peptide-lysine-N-acetyltransferase activity)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071929"(alpha-tubulin acetylation)|go:"GO:0072686"(mitotic spindle)|go:"GO:0106077"(histone succinylation)|go:"GO:0106078"(histone succinyltransferase activity)|go:"GO:0106227"(peptidyl-lysine glutarylation)|go:"GO:0106229"(histone glutaryltransferase activity)|go:"GO:1903010"(regulation of bone development)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:2000036"(regulation of stem cell population maintenance)|go:"GO:2000727"(positive regulation of cardiac muscle cell differentiation)|interpro:IPR000182(GCN5-related N-acetyltransferase)|interpro:IPR001487(Bromodomain)|interpro:IPR009464(PCAF, N-terminal)|interpro:IPR016181(Acyl-CoA N-acyltransferase)|interpro:IPR016376(Histone acetylase PCAF)|interpro:IPR018359|interpro:IPR036427|interpro:IPR037800|mint:Q92830|rcsb pdb:1F68|rcsb pdb:1Z4R|rcsb pdb:3D7C|rcsb pdb:5H84|rcsb pdb:5H86|rcsb pdb:5MLJ|rcsb pdb:5TRL|rcsb pdb:5TRM|rcsb pdb:6J3P|reactome:R-HSA-1912408|reactome:R-HSA-210744|reactome:R-HSA-2122947|reactome:R-HSA-2644606|reactome:R-HSA-2894862|reactome:R-HSA-3214847|reactome:R-HSA-350054|reactome:R-HSA-5250924|reactome:R-HSA-5689880|reactome:R-HSA-73762|reactome:R-HSA-8941856|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005671"(obsolete Ada2/Gcn5/Ada3 transcription activator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007507"(heart development)|go:"GO:0007616"(long-term memory)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0010484"(H3 histone acetyltransferase activity)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0016573"(histone acetylation)|go:"GO:0016578"(histone deubiquitination)|go:"GO:0018393"(internal peptidyl-lysine acetylation)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0021537"(telencephalon development)|go:"GO:0022037"(metencephalon development)|go:"GO:0030901"(midbrain development)|go:"GO:0030914"|go:"GO:0031346"(positive regulation of cell projection organization)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0033276"(transcription factor TFTC complex)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0043997"("histone acetyltransferase activity (H4-K12 specific)")|go:"GO:0044154"(histone H3-K14 acetylation)|go:"GO:0045589"(regulation of regulatory T cell differentiation)|reactome:R-HSA-9013508|reactome:R-HSA-9013695|refseq:XP_016879937.1|dip:DIP-28146N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:8n1lOTC7I8dP3RY1IEUtIkJiSXc9606 rogid:PwDTlmU+caK91Xbiv7xm4xejZok9606 intact-crc:46AE6105F20EC20E|rigid:G/EnPPzh4kUfo1qCim0ykCN+Qqw false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UPT9 uniprotkb:Q7KZF4 intact:EBI-723510|ensembl:ENSP00000261497|uniprotkb:A0JNS3|uniprotkb:Q2NLE2|uniprotkb:Q6MZY4|uniprotkb:Q8TBS8|uniprotkb:Q96IW5 intact:EBI-1044112|uniprotkb:Q13122|ensembl:ENSP00000346762|uniprotkb:Q96AG0 psi-mi:ubp22_human(display_long)|uniprotkb:Ubiquitin-specific-processing protease 22(gene name synonym)|uniprotkb:Deubiquitinating enzyme 22(gene name synonym)|uniprotkb:USP22(gene name)|psi-mi:USP22(display_short)|uniprotkb:KIAA1063(gene name synonym)|uniprotkb:USP3L(gene name synonym)|uniprotkb:Ubiquitin thioesterase 22(gene name synonym) psi-mi:snd1_human(display_long)|uniprotkb:100 kDa coactivator(gene name synonym)|uniprotkb:EBNA2 coactivator p100(gene name synonym)|uniprotkb:Tudor domain-containing protein 11(gene name synonym)|uniprotkb:SND1(gene name)|psi-mi:SND1(display_short)|uniprotkb:p100 co-activator(gene name synonym)|uniprotkb:TDRD11(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512240|imex:IM-12079-71 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_056091.1|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|go:"GO:0007049"(cell cycle)|interpro:IPR028889|interpro:IPR038765|mint:Q9UPT9|go:"GO:0008270"(zinc ion binding)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|reactome:R-HSA-3214847|go:"GO:0016574"(histone ubiquitination)|go:"GO:0016578"(histone deubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019899"(enzyme binding)|reactome:R-HSA-5689880|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|ensembl:ENSG00000124422(gene)|ensembl:ENST00000261497(transcript)|go:"GO:0000124"(SAGA complex)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process) refseq:NP_055205.2|ensembl:ENSG00000197157(gene)|ensembl:ENST00000354725(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0004518"(nuclease activity)|go:"GO:0004519"(endonuclease activity)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006401"(RNA catabolic process)|go:"GO:0010564"(regulation of cell cycle process)|go:"GO:0010587"(miRNA catabolic process)|go:"GO:0016020"(membrane)|go:"GO:0016442"(RISC complex)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0042470"(melanosome)|go:"GO:0045296"(cadherin binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097433"(dense body)|go:"GO:1905172"(RISC complex binding)|interpro:IPR002071(Thermonuclease active site)|interpro:IPR002999(Tudor)|interpro:IPR016071("Staphylococcal nuclease (SNase-like), OB-fold")|interpro:IPR016685(RNA-induced silencing complex, nuclease component Tudor-SN)|interpro:IPR035437|mint:Q7KZF4|rcsb pdb:2E6N|rcsb pdb:2HQE|rcsb pdb:2HQX|rcsb pdb:2O4X|rcsb pdb:3BDL|rcsb pdb:3OMC|rcsb pdb:3OMG|rcsb pdb:4QMG|rcsb pdb:5M9O|reactome:R-HSA-6802952|dip:DIP-29613N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:8n1lOTC7I8dP3RY1IEUtIkJiSXc9606 rogid:I9JNlRfASs5dwk0JZQ+F+GsW94g9606 intact-crc:46AE6105F20EC20E|rigid:G/EnPPzh4kUfo1qCim0ykCN+Qqw false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UPT9 uniprotkb:Q9Y6J9 intact:EBI-723510|ensembl:ENSP00000261497|uniprotkb:A0JNS3|uniprotkb:Q2NLE2|uniprotkb:Q6MZY4|uniprotkb:Q8TBS8|uniprotkb:Q96IW5 intact:EBI-743984|uniprotkb:Q96HA6|uniprotkb:B2RAT0|ensembl:ENSP00000294168 psi-mi:ubp22_human(display_long)|uniprotkb:Ubiquitin-specific-processing protease 22(gene name synonym)|uniprotkb:Deubiquitinating enzyme 22(gene name synonym)|uniprotkb:USP22(gene name)|psi-mi:USP22(display_short)|uniprotkb:KIAA1063(gene name synonym)|uniprotkb:USP3L(gene name synonym)|uniprotkb:Ubiquitin thioesterase 22(gene name synonym) psi-mi:taf6l_human(display_long)|uniprotkb:PCAF-associated factor 65-alpha(gene name synonym)|uniprotkb:TAF6L(gene name)|psi-mi:TAF6L(display_short)|uniprotkb:PAF65A(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512240|imex:IM-12079-71 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_056091.1|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|go:"GO:0007049"(cell cycle)|interpro:IPR028889|interpro:IPR038765|mint:Q9UPT9|go:"GO:0008270"(zinc ion binding)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|reactome:R-HSA-3214847|go:"GO:0016574"(histone ubiquitination)|go:"GO:0016578"(histone deubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019899"(enzyme binding)|reactome:R-HSA-5689880|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|ensembl:ENSG00000124422(gene)|ensembl:ENST00000261497(transcript)|go:"GO:0000124"(SAGA complex)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process) refseq:NP_006464.1|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0016251"(RNA polymerase II general transcription initiation factor activity)|go:"GO:0016573"(histone acetylation)|go:"GO:0030914"|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046695"("SLIK (SAGA-like) complex")|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904672"(regulation of somatic stem cell population maintenance)|interpro:IPR004823("TATA box binding protein associated factor (TAF)")|interpro:IPR009072(Histone-fold)|interpro:IPR011442(Protein of unknown function DUF1546)|interpro:IPR037796|mint:Q9Y6J9|reactome:R-HSA-3214847|ensembl:ENSG00000162227(gene)|ensembl:ENST00000294168(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000124"(SAGA complex)|go:"GO:0003677"(DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005669"(transcription factor TFIID complex)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006355"(regulation of transcription, DNA-templated) psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:8n1lOTC7I8dP3RY1IEUtIkJiSXc9606 rogid:ZcrK24blWTsAkCgruDbSiUflbtA9606 intact-crc:46AE6105F20EC20E|rigid:G/EnPPzh4kUfo1qCim0ykCN+Qqw false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UPT9 uniprotkb:O75529 intact:EBI-723510|ensembl:ENSP00000261497|uniprotkb:A0JNS3|uniprotkb:Q2NLE2|uniprotkb:Q6MZY4|uniprotkb:Q8TBS8|uniprotkb:Q96IW5 intact:EBI-1785876|uniprotkb:Q8IW31|uniprotkb:Q5TDI6|uniprotkb:Q5TDI5|ensembl:ENSP00000258281 psi-mi:ubp22_human(display_long)|uniprotkb:Ubiquitin-specific-processing protease 22(gene name synonym)|uniprotkb:Deubiquitinating enzyme 22(gene name synonym)|uniprotkb:USP22(gene name)|psi-mi:USP22(display_short)|uniprotkb:KIAA1063(gene name synonym)|uniprotkb:USP3L(gene name synonym)|uniprotkb:Ubiquitin thioesterase 22(gene name synonym) psi-mi:taf5l_human(display_long)|uniprotkb:TAF5L(gene name)|psi-mi:TAF5L(display_short)|uniprotkb:PAF65B(gene name synonym)|uniprotkb:PCAF-associated factor 65 beta(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512240|imex:IM-12079-71 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_056091.1|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|go:"GO:0007049"(cell cycle)|interpro:IPR028889|interpro:IPR038765|mint:Q9UPT9|go:"GO:0008270"(zinc ion binding)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|reactome:R-HSA-3214847|go:"GO:0016574"(histone ubiquitination)|go:"GO:0016578"(histone deubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019899"(enzyme binding)|reactome:R-HSA-5689880|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|ensembl:ENSG00000124422(gene)|ensembl:ENST00000261497(transcript)|go:"GO:0000124"(SAGA complex)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process) refseq:NP_001020418.1|refseq:NP_055224.1|refseq:XP_005273156.1|dip:DIP-28147N|ensembl:ENSG00000135801(gene)|ensembl:ENST00000258281(transcript)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0016607"(nuclear speck)|go:"GO:0030914"|go:"GO:0033276"(transcription factor TFTC complex)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:1904672"(regulation of somatic stem cell population maintenance)|interpro:IPR001680(WD40 repeat)|interpro:IPR007582(WD40 associated region in TFIID subunit)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|interpro:IPR037264|interpro:IPR037783|interpro:IPR037826|mint:O75529|reactome:R-HSA-3214847 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:8n1lOTC7I8dP3RY1IEUtIkJiSXc9606 rogid:3D2y64CWMvwok3BvV2CpH6iX84E9606 intact-crc:46AE6105F20EC20E|rigid:G/EnPPzh4kUfo1qCim0ykCN+Qqw false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UPT9 uniprotkb:Q96GX2 intact:EBI-723510|ensembl:ENSP00000261497|uniprotkb:A0JNS3|uniprotkb:Q2NLE2|uniprotkb:Q6MZY4|uniprotkb:Q8TBS8|uniprotkb:Q96IW5 intact:EBI-2512242|ensembl:ENSP00000430000 psi-mi:ubp22_human(display_long)|uniprotkb:Ubiquitin-specific-processing protease 22(gene name synonym)|uniprotkb:Deubiquitinating enzyme 22(gene name synonym)|uniprotkb:USP22(gene name)|psi-mi:USP22(display_short)|uniprotkb:KIAA1063(gene name synonym)|uniprotkb:USP3L(gene name synonym)|uniprotkb:Ubiquitin thioesterase 22(gene name synonym) psi-mi:a7l3b_human(display_long)|uniprotkb:ATXN7L3B(gene name)|psi-mi:ATXN7L3B(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512240|imex:IM-12079-71 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_056091.1|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|go:"GO:0007049"(cell cycle)|interpro:IPR028889|interpro:IPR038765|mint:Q9UPT9|go:"GO:0008270"(zinc ion binding)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|reactome:R-HSA-3214847|go:"GO:0016574"(histone ubiquitination)|go:"GO:0016578"(histone deubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019899"(enzyme binding)|reactome:R-HSA-5689880|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|ensembl:ENSG00000124422(gene)|ensembl:ENST00000261497(transcript)|go:"GO:0000124"(SAGA complex)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process) ensembl:ENSG00000253719(gene)|ensembl:ENST00000519948(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0010468"(regulation of gene expression)|interpro:IPR042933|refseq:NP_001129734.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:8n1lOTC7I8dP3RY1IEUtIkJiSXc9606 rogid:HgnLzv0EbSgtSc0LsZm/yJ7qomE9606 intact-crc:46AE6105F20EC20E|rigid:G/EnPPzh4kUfo1qCim0ykCN+Qqw false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UPT9 uniprotkb:Q96EB6 intact:EBI-723510|ensembl:ENSP00000261497|uniprotkb:A0JNS3|uniprotkb:Q2NLE2|uniprotkb:Q6MZY4|uniprotkb:Q8TBS8|uniprotkb:Q96IW5 intact:EBI-1802965|uniprotkb:Q2XNF6|uniprotkb:Q5JVQ0|uniprotkb:Q9GZR9|uniprotkb:Q9Y6F0|ensembl:ENSP00000212015 psi-mi:ubp22_human(display_long)|uniprotkb:Ubiquitin-specific-processing protease 22(gene name synonym)|uniprotkb:Deubiquitinating enzyme 22(gene name synonym)|uniprotkb:USP22(gene name)|psi-mi:USP22(display_short)|uniprotkb:KIAA1063(gene name synonym)|uniprotkb:USP3L(gene name synonym)|uniprotkb:Ubiquitin thioesterase 22(gene name synonym) psi-mi:sir1_human(display_long)|uniprotkb:NAD-dependent protein deacylase sirtuin-1(gene name synonym)|uniprotkb:SIRT1(gene name)|psi-mi:SIRT1(display_short)|uniprotkb:SIR2L1(gene name synonym)|uniprotkb:SIR2-like protein 1(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512240|imex:IM-12079-71 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_056091.1|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|go:"GO:0007049"(cell cycle)|interpro:IPR028889|interpro:IPR038765|mint:Q9UPT9|go:"GO:0008270"(zinc ion binding)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|reactome:R-HSA-3214847|go:"GO:0016574"(histone ubiquitination)|go:"GO:0016578"(histone deubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019899"(enzyme binding)|reactome:R-HSA-5689880|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|ensembl:ENSG00000124422(gene)|ensembl:ENST00000261497(transcript)|go:"GO:0000124"(SAGA complex)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process) refseq:NP_001135970.1|refseq:NP_036370.2|refseq:NP_001300978.1|dip:DIP-29757N|go:"GO:2000773"(negative regulation of cellular senescence)|go:"GO:2000774"(positive regulation of cellular senescence)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR026590|interpro:IPR026591|interpro:IPR029035|mint:Q96EB6|rcsb pdb:4I5I|rcsb pdb:4IF6|rcsb pdb:4IG9|rcsb pdb:4KXQ|rcsb pdb:4ZZH|rcsb pdb:4ZZI|rcsb pdb:4ZZJ|rcsb pdb:5BTR|reactome:R-HSA-3371453|reactome:R-HSA-400253|reactome:R-HSA-427359|reactome:R-HSA-9617629|reactome:R-HSA-9707616|go:"GO:2000757"(negative regulation of peptidyl-lysine acetylation)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006346"(DNA methylation-dependent heterochromatin assembly)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006642"(triglyceride mobilization)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0007517"(muscle organ development)|go:"GO:0007569"(cell aging)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010824"(regulation of centrosome duplication)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010883"(regulation of lipid storage)|go:"GO:0010906"(regulation of glucose metabolic process)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0005739"(mitochondrion)|ensembl:ENSG00000096717(gene)|ensembl:ENST00000212015(transcript)|go:"GO:0000012"(single strand break repair)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000183"(rDNA heterochromatin assembly)|go:"GO:0000731"(DNA synthesis involved in DNA repair)|go:"GO:0000785"(chromatin)|go:"GO:0000791"(euchromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001525"(angiogenesis)|go:"GO:0001542"(ovulation from ovarian follicle)|go:"GO:0001650"(fibrillar center)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002039"(p53 binding)|go:"GO:0002821"(positive regulation of adaptive immune response)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005677"(chromatin silencing complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0000720"(pyrimidine dimer repair by nucleotide-excision repair)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016605"(PML body)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0017136"(NAD-dependent histone deacetylase activity)|go:"GO:0018394"(peptidyl-lysine acetylation)|go:"GO:0019213"(deacetylase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031393"(negative regulation of prostaglandin biosynthetic process)|go:"GO:0031507"(heterochromatin assembly)|go:"GO:0031648"(protein destabilization)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0032071"(regulation of endodeoxyribonuclease activity)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032868"(response to insulin)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0033553"(rDNA heterochromatin)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034391"(regulation of smooth muscle cell apoptotic process)|go:"GO:0034979"(NAD-dependent protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0035356"(cellular triglyceride homeostasis)|go:"GO:0035358"(regulation of peroxisome proliferator activated receptor signaling pathway)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042326"(negative regulation of phosphorylation)|go:"GO:0042393"(histone binding)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042595"(behavioral response to starvation)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043398"(HLH domain binding)|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043518"(negative regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0045348"(positive regulation of MHC class II biosynthetic process)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045722"(positive regulation of gluconeogenesis)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0046969"("NAD-dependent histone deacetylase activity (H3-K9 specific)")|go:"GO:0050872"(white fat cell differentiation)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0051097"(negative regulation of helicase activity)|go:"GO:0051152"(positive regulation of smooth muscle cell differentiation)|go:"GO:0051574"(positive regulation of histone H3-K9 methylation)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0055089"(fatty acid homeostasis)|go:"GO:0060766"(negative regulation of androgen receptor signaling pathway)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070403"(NAD+ binding)|go:"GO:0070829"(obsolete heterochromatin maintenance)|go:"GO:0070857"(regulation of bile acid biosynthetic process)|go:"GO:0070914"(UV-damage excision repair)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0044321"(response to leptin)|go:"GO:0071441"(negative regulation of histone H3-K14 acetylation)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0071900"(regulation of protein serine/threonine kinase activity)|go:"GO:0090335"(regulation of brown fat cell differentiation)|go:"GO:0090400"(stress-induced premature senescence)|go:"GO:0106230"(protein depropionylation)|go:"GO:0106231"(protein-propionyllysine depropionylase activity)|go:"GO:1900034"(regulation of cellular response to heat)|go:"GO:1900113"(negative regulation of histone H3-K9 trimethylation)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901984"(negative regulation of protein acetylation)|go:"GO:1902166"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902237"(positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1904179"(positive regulation of adipose tissue development)|go:"GO:1990254"(keratin filament binding)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000111"(positive regulation of macrophage apoptotic process)|go:"GO:2000480"(negative regulation of cAMP-dependent protein kinase activity)|go:"GO:2000481"(positive regulation of cAMP-dependent protein kinase activity)|go:"GO:2000619"(negative regulation of histone H4-K16 acetylation)|go:"GO:2000655"(negative regulation of cellular response to testosterone stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor) psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:8n1lOTC7I8dP3RY1IEUtIkJiSXc9606 rogid:h3zVepuhRhzlINCluVuAn71Btjc9606 intact-crc:46AE6105F20EC20E|rigid:G/EnPPzh4kUfo1qCim0ykCN+Qqw false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UPT9 uniprotkb:A5YKK6 intact:EBI-723510|ensembl:ENSP00000261497|uniprotkb:A0JNS3|uniprotkb:Q2NLE2|uniprotkb:Q6MZY4|uniprotkb:Q8TBS8|uniprotkb:Q96IW5 intact:EBI-1222758|uniprotkb:Q68DX7|uniprotkb:Q7Z3K2|uniprotkb:Q8IWB8|uniprotkb:Q8TB53|uniprotkb:Q9BVZ6|uniprotkb:Q9UFR8|uniprotkb:Q9UI27|uniprotkb:Q9Y2L0|intact:EBI-2561986|ensembl:ENSP00000320949 psi-mi:ubp22_human(display_long)|uniprotkb:Ubiquitin-specific-processing protease 22(gene name synonym)|uniprotkb:Deubiquitinating enzyme 22(gene name synonym)|uniprotkb:USP22(gene name)|psi-mi:USP22(display_short)|uniprotkb:KIAA1063(gene name synonym)|uniprotkb:USP3L(gene name synonym)|uniprotkb:Ubiquitin thioesterase 22(gene name synonym) psi-mi:cnot1_human(display_long)|uniprotkb:CNOT1(gene name)|psi-mi:CNOT1(display_short)|uniprotkb:CDC39(gene name synonym)|uniprotkb:KIAA1007(gene name synonym)|uniprotkb:NOT1(gene name synonym)|uniprotkb:Negative regulator of transcription subunit 1 homolog(gene name synonym)|uniprotkb:CCR4-associated factor 1(gene name synonym)|uniprotkb:AD-005(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512240|imex:IM-12079-71 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_056091.1|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|go:"GO:0007049"(cell cycle)|interpro:IPR028889|interpro:IPR038765|mint:Q9UPT9|go:"GO:0008270"(zinc ion binding)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|reactome:R-HSA-3214847|go:"GO:0016574"(histone ubiquitination)|go:"GO:0016578"(histone deubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019899"(enzyme binding)|reactome:R-HSA-5689880|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|ensembl:ENSG00000124422(gene)|ensembl:ENST00000261497(transcript)|go:"GO:0000124"(SAGA complex)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process) refseq:NP_057368.3|refseq:NP_996882.1|refseq:NP_001252541.1|dip:DIP-44954N|ensembl:ENSG00000125107(gene)|ensembl:ENST00000317147(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000288"(nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|go:"GO:0000932"(P-body)|go:"GO:0001829"(trophectodermal cell differentiation)|go:"GO:0003723"(RNA binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0010606"(positive regulation of cytoplasmic mRNA processing body assembly)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030014"(CCR4-NOT complex)|go:"GO:0030015"(CCR4-NOT core complex)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0033147"(negative regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0035195"(gene silencing by miRNA)|go:"GO:0042974"(retinoic acid receptor binding)|go:"GO:0048387"(negative regulation of retinoic acid receptor signaling pathway)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060213"("positive regulation of nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0061014"(positive regulation of mRNA catabolic process)|go:"GO:0070016"(armadillo repeat domain binding)|go:"GO:0090503"(RNA phosphodiester bond hydrolysis, exonucleolytic)|go:"GO:1900153"(positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|go:"GO:2000036"(regulation of stem cell population maintenance)|interpro:IPR007196(CCR4-Not complex component, Not1)|interpro:IPR016021(MIF4-like, type 1/2/3)|interpro:IPR024557|interpro:IPR032191|interpro:IPR032193|interpro:IPR032194|interpro:IPR038535|interpro:IPR040398|mint:A5YKK6|rcsb pdb:4C0D|rcsb pdb:4CQO|rcsb pdb:4CRU|rcsb pdb:4CRV|rcsb pdb:4CRW|rcsb pdb:4CT4|rcsb pdb:4CT6|rcsb pdb:4CT7|rcsb pdb:4GMJ|rcsb pdb:4GML|rcsb pdb:4J8S|rcsb pdb:5ANR|rcsb pdb:5FU6|rcsb pdb:5FU7|rcsb pdb:5ONA|reactome:R-HSA-429947|reactome:R-HSA-6804115 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:8n1lOTC7I8dP3RY1IEUtIkJiSXc9606 rogid:qYUeacTR9wuDH02Uy8CqCcaaXOY9606 intact-crc:46AE6105F20EC20E|rigid:G/EnPPzh4kUfo1qCim0ykCN+Qqw false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UPT9 uniprotkb:Q9Y2G5 intact:EBI-723510|ensembl:ENSP00000261497|uniprotkb:A0JNS3|uniprotkb:Q2NLE2|uniprotkb:Q6MZY4|uniprotkb:Q8TBS8|uniprotkb:Q96IW5 intact:EBI-2512252|ensembl:ENSP00000339613|uniprotkb:Q6PJV1|uniprotkb:Q8WWU6|uniprotkb:Q9UFY3|uniprotkb:Q9BQS5|uniprotkb:Q7Z4N0|uniprotkb:Q9BQS4 psi-mi:ubp22_human(display_long)|uniprotkb:Ubiquitin-specific-processing protease 22(gene name synonym)|uniprotkb:Deubiquitinating enzyme 22(gene name synonym)|uniprotkb:USP22(gene name)|psi-mi:USP22(display_short)|uniprotkb:KIAA1063(gene name synonym)|uniprotkb:USP3L(gene name synonym)|uniprotkb:Ubiquitin thioesterase 22(gene name synonym) psi-mi:ofut2_human(display_long)|uniprotkb:POFUT2(gene name)|psi-mi:POFUT2(display_short)|uniprotkb:C21orf80(gene name synonym)|uniprotkb:FUT13(gene name synonym)|uniprotkb:KIAA0958(gene name synonym)|uniprotkb:Peptide-O-fucosyltransferase 2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512240|imex:IM-12079-71 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_056091.1|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|go:"GO:0007049"(cell cycle)|interpro:IPR028889|interpro:IPR038765|mint:Q9UPT9|go:"GO:0008270"(zinc ion binding)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|reactome:R-HSA-3214847|go:"GO:0016574"(histone ubiquitination)|go:"GO:0016578"(histone deubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019899"(enzyme binding)|reactome:R-HSA-5689880|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|ensembl:ENSG00000124422(gene)|ensembl:ENST00000261497(transcript)|go:"GO:0000124"(SAGA complex)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process) ensembl:ENSG00000186866(gene)|ensembl:ENST00000349485(transcript)|go:"GO:0001707"(mesoderm formation)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006004"(fucose metabolic process)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010717"(regulation of epithelial to mesenchymal transition)|go:"GO:0036066"(protein O-linked fucosylation)|go:"GO:0046922"(peptide-O-fucosyltransferase activity)|go:"GO:0051046"(regulation of secretion)|go:"GO:1903334"(positive regulation of protein folding)|interpro:IPR019378|rcsb pdb:4AP5|rcsb pdb:4AP6|reactome:R-HSA-5173214|refseq:NP_056042.1|refseq:NP_598368.2 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:8n1lOTC7I8dP3RY1IEUtIkJiSXc9606 rogid:mddxUsRIT26cLtwaiPaQrEINwFA9606 intact-crc:46AE6105F20EC20E|rigid:G/EnPPzh4kUfo1qCim0ykCN+Qqw false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UPT9 uniprotkb:Q86TJ2 intact:EBI-723510|ensembl:ENSP00000261497|uniprotkb:A0JNS3|uniprotkb:Q2NLE2|uniprotkb:Q6MZY4|uniprotkb:Q8TBS8|uniprotkb:Q96IW5 intact:EBI-2512219|uniprotkb:Q6MZG9|uniprotkb:B3KSN0|uniprotkb:B3KU86|uniprotkb:A4QMR7|uniprotkb:A0AUJ8|ensembl:ENSP00000308022 psi-mi:ubp22_human(display_long)|uniprotkb:Ubiquitin-specific-processing protease 22(gene name synonym)|uniprotkb:Deubiquitinating enzyme 22(gene name synonym)|uniprotkb:USP22(gene name)|psi-mi:USP22(display_short)|uniprotkb:KIAA1063(gene name synonym)|uniprotkb:USP3L(gene name synonym)|uniprotkb:Ubiquitin thioesterase 22(gene name synonym) psi-mi:tad2b_human(display_long)|uniprotkb:TADA2B(gene name)|psi-mi:TADA2B(display_short)|uniprotkb:ADA2B(gene name synonym)|uniprotkb:ADA2-like protein beta(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512240|imex:IM-12079-71 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_056091.1|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|go:"GO:0007049"(cell cycle)|interpro:IPR028889|interpro:IPR038765|mint:Q9UPT9|go:"GO:0008270"(zinc ion binding)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|reactome:R-HSA-3214847|go:"GO:0016574"(histone ubiquitination)|go:"GO:0016578"(histone deubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019899"(enzyme binding)|reactome:R-HSA-5689880|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|ensembl:ENSG00000124422(gene)|ensembl:ENST00000261497(transcript)|go:"GO:0000124"(SAGA complex)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process) refseq:XP_011511897.1|refseq:NP_689506.2|interpro:IPR016827(Transcriptional adaptor 2)|interpro:IPR017884|interpro:IPR017930|interpro:IPR036388|interpro:IPR041983|interpro:IPR043145|mint:Q86TJ2|reactome:R-HSA-3214847|reactome:R-HSA-5689880|interpro:IPR009057(Homeodomain-like)|ensembl:ENSG00000173011(gene)|ensembl:ENST00000310074(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008270"(zinc ion binding)|go:"GO:0030914"|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0070461"(SAGA-type complex)|interpro:IPR000433(Zinc finger, ZZ-type)|interpro:IPR001005(SANT, DNA-binding) psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:8n1lOTC7I8dP3RY1IEUtIkJiSXc9606 rogid:ShA8/bknqf6XcaEWL3YFWOz9s9c9606 intact-crc:46AE6105F20EC20E|rigid:G/EnPPzh4kUfo1qCim0ykCN+Qqw false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UPT9 uniprotkb:O75528 intact:EBI-723510|ensembl:ENSP00000261497|uniprotkb:A0JNS3|uniprotkb:Q2NLE2|uniprotkb:Q6MZY4|uniprotkb:Q8TBS8|uniprotkb:Q96IW5 intact:EBI-473249|uniprotkb:Q9UFS2|intact:EBI-28973289|ensembl:ENSP00000307684|ensembl:ENSP00000393471|uniprotkb:Q6FI83 psi-mi:ubp22_human(display_long)|uniprotkb:Ubiquitin-specific-processing protease 22(gene name synonym)|uniprotkb:Deubiquitinating enzyme 22(gene name synonym)|uniprotkb:USP22(gene name)|psi-mi:USP22(display_short)|uniprotkb:KIAA1063(gene name synonym)|uniprotkb:USP3L(gene name synonym)|uniprotkb:Ubiquitin thioesterase 22(gene name synonym) psi-mi:tada3_human(display_long)|uniprotkb:ADA3 homolog(gene name synonym)|uniprotkb:STAF54(gene name synonym)|uniprotkb:TADA3(gene name)|psi-mi:TADA3(display_short)|uniprotkb:ADA3(gene name synonym)|uniprotkb:TADA3L(gene name synonym)|uniprotkb:Transcriptional adapter 3-like(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512240|imex:IM-12079-71 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_056091.1|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|go:"GO:0007049"(cell cycle)|interpro:IPR028889|interpro:IPR038765|mint:Q9UPT9|go:"GO:0008270"(zinc ion binding)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|reactome:R-HSA-3214847|go:"GO:0016574"(histone ubiquitination)|go:"GO:0016578"(histone deubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019899"(enzyme binding)|reactome:R-HSA-5689880|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|ensembl:ENSG00000124422(gene)|ensembl:ENST00000261497(transcript)|go:"GO:0000124"(SAGA complex)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process) ensembl:ENSG00000171148(gene)|ensembl:ENST00000301964(transcript)|ensembl:ENST00000440161(transcript)|go:"GO:0000124"(SAGA complex)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005671"(obsolete Ada2/Gcn5/Ada3 transcription activator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0030520"(intracellular estrogen receptor signaling pathway)|go:"GO:0030914"|go:"GO:0031063"(regulation of histone deacetylation)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0033276"(transcription factor TFTC complex)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090043"(regulation of tubulin deacetylation)|interpro:IPR019340|mint:O75528|reactome:R-HSA-3214847|reactome:R-HSA-5689880|ensembl:ENSP00000307684|ensembl:ENST00000343450|ensembl:ENSP00000343649|ensembl:ENSP00000393471|refseq:NP_006345.1|refseq:NP_597814.1|refseq:NP_001265199.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:8n1lOTC7I8dP3RY1IEUtIkJiSXc9606 rogid:5NQkQiw+G/8uL2fjoMgW8+mTB8o9606 intact-crc:46AE6105F20EC20E|rigid:G/EnPPzh4kUfo1qCim0ykCN+Qqw false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UPT9 uniprotkb:Q5T6C5 intact:EBI-723510|ensembl:ENSP00000261497|uniprotkb:A0JNS3|uniprotkb:Q2NLE2|uniprotkb:Q6MZY4|uniprotkb:Q8TBS8|uniprotkb:Q96IW5 intact:EBI-949168|ensembl:ENSP00000358886 psi-mi:ubp22_human(display_long)|uniprotkb:Ubiquitin-specific-processing protease 22(gene name synonym)|uniprotkb:Deubiquitinating enzyme 22(gene name synonym)|uniprotkb:USP22(gene name)|psi-mi:USP22(display_short)|uniprotkb:KIAA1063(gene name synonym)|uniprotkb:USP3L(gene name synonym)|uniprotkb:Ubiquitin thioesterase 22(gene name synonym) psi-mi:at7l2_human(display_long)|uniprotkb:ATXN7L2(gene name)|psi-mi:ATXN7L2(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512240|imex:IM-12079-71 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_056091.1|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|go:"GO:0007049"(cell cycle)|interpro:IPR028889|interpro:IPR038765|mint:Q9UPT9|go:"GO:0008270"(zinc ion binding)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|reactome:R-HSA-3214847|go:"GO:0016574"(histone ubiquitination)|go:"GO:0016578"(histone deubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019899"(enzyme binding)|reactome:R-HSA-5689880|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|ensembl:ENSG00000124422(gene)|ensembl:ENST00000261497(transcript)|go:"GO:0000124"(SAGA complex)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process) ensembl:ENSG00000162650(gene)|ensembl:ENST00000369870(transcript)|interpro:IPR013243(SCA7)|mint:Q5T6C5|refseq:NP_699171.3 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:8n1lOTC7I8dP3RY1IEUtIkJiSXc9606 rogid:kPIjJ2NIDAAHLvVnRNzSD61XZD89606 intact-crc:46AE6105F20EC20E|rigid:G/EnPPzh4kUfo1qCim0ykCN+Qqw false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UPT9 uniprotkb:Q8NEM7 intact:EBI-723510|ensembl:ENSP00000261497|uniprotkb:A0JNS3|uniprotkb:Q2NLE2|uniprotkb:Q6MZY4|uniprotkb:Q8TBS8|uniprotkb:Q96IW5 intact:EBI-946984|uniprotkb:Q71RF3|uniprotkb:Q9Y6A6|ensembl:ENSP00000218894|uniprotkb:E7ER46 psi-mi:ubp22_human(display_long)|uniprotkb:Ubiquitin-specific-processing protease 22(gene name synonym)|uniprotkb:Deubiquitinating enzyme 22(gene name synonym)|uniprotkb:USP22(gene name)|psi-mi:USP22(display_short)|uniprotkb:KIAA1063(gene name synonym)|uniprotkb:USP3L(gene name synonym)|uniprotkb:Ubiquitin thioesterase 22(gene name synonym) psi-mi:sp20h_human(display_long)|uniprotkb:SUPT20H(gene name)|psi-mi:SUPT20H(display_short)|uniprotkb:C13orf19(gene name synonym)|uniprotkb:FAM48A(gene name synonym)|uniprotkb:p38-interacting protein(gene name synonym)|uniprotkb:FP757(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512240|imex:IM-12079-71 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_056091.1|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|go:"GO:0007049"(cell cycle)|interpro:IPR028889|interpro:IPR038765|mint:Q9UPT9|go:"GO:0008270"(zinc ion binding)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|reactome:R-HSA-3214847|go:"GO:0016574"(histone ubiquitination)|go:"GO:0016578"(histone deubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019899"(enzyme binding)|reactome:R-HSA-5689880|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|ensembl:ENSG00000124422(gene)|ensembl:ENST00000261497(transcript)|go:"GO:0000124"(SAGA complex)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process) refseq:NP_001265409.1|refseq:NP_001265410.1|refseq:NP_001265411.1|refseq:NP_001014308.2|refseq:NP_060039.1|ensembl:ENSG00000102710(gene)|ensembl:ENST00000350612(transcript)|go:"GO:0000124"(SAGA complex)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006914"(autophagy)|go:"GO:0007369"(gastrulation)|go:"GO:0070461"(SAGA-type complex)|interpro:IPR021950|mint:Q8NEM7|reactome:R-HSA-3214847 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:8n1lOTC7I8dP3RY1IEUtIkJiSXc9606 rogid:7s9ChKIewCopRWC7otwhnH6hYEs9606 intact-crc:46AE6105F20EC20E|rigid:G/EnPPzh4kUfo1qCim0ykCN+Qqw false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UPT9 uniprotkb:Q96BN2 intact:EBI-723510|ensembl:ENSP00000261497|uniprotkb:A0JNS3|uniprotkb:Q2NLE2|uniprotkb:Q6MZY4|uniprotkb:Q8TBS8|uniprotkb:Q96IW5 intact:EBI-2512236|ensembl:ENSP00000356848|uniprotkb:A8K4J9 psi-mi:ubp22_human(display_long)|uniprotkb:Ubiquitin-specific-processing protease 22(gene name synonym)|uniprotkb:Deubiquitinating enzyme 22(gene name synonym)|uniprotkb:USP22(gene name)|psi-mi:USP22(display_short)|uniprotkb:KIAA1063(gene name synonym)|uniprotkb:USP3L(gene name synonym)|uniprotkb:Ubiquitin thioesterase 22(gene name synonym) psi-mi:tada1_human(display_long)|uniprotkb:TADA1(gene name)|psi-mi:TADA1(display_short)|uniprotkb:TADA1L(gene name synonym)|uniprotkb:Transcriptional adapter 1-like protein(gene name synonym)|uniprotkb:SPT3-associated factor 42(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512240|imex:IM-12079-71 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_056091.1|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|go:"GO:0007049"(cell cycle)|interpro:IPR028889|interpro:IPR038765|mint:Q9UPT9|go:"GO:0008270"(zinc ion binding)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|reactome:R-HSA-3214847|go:"GO:0016574"(histone ubiquitination)|go:"GO:0016578"(histone deubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019899"(enzyme binding)|reactome:R-HSA-5689880|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|ensembl:ENSG00000124422(gene)|ensembl:ENST00000261497(transcript)|go:"GO:0000124"(SAGA complex)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process) ensembl:ENSG00000152382(gene)|ensembl:ENST00000367874(transcript)|go:"GO:0000124"(SAGA complex)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0030914"|go:"GO:0043966"(histone H3 acetylation)|interpro:IPR024738|mint:Q96BN2|reactome:R-HSA-3214847|refseq:NP_444281.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:8n1lOTC7I8dP3RY1IEUtIkJiSXc9606 rogid:07aGEsEjtD884LVJ6Jlj12+TdK49606 intact-crc:46AE6105F20EC20E|rigid:G/EnPPzh4kUfo1qCim0ykCN+Qqw false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UPT9 uniprotkb:Q16594 intact:EBI-723510|ensembl:ENSP00000261497|uniprotkb:A0JNS3|uniprotkb:Q2NLE2|uniprotkb:Q6MZY4|uniprotkb:Q8TBS8|uniprotkb:Q96IW5 intact:EBI-712521|ensembl:ENSP00000370193|ensembl:ENSP00000421873|ensembl:ENSP00000477611|ensembl:ENSP00000477750|ensembl:ENSP00000478935|ensembl:ENSP00000217893|uniprotkb:Q5U0D1|uniprotkb:Q9BTS1|uniprotkb:D3DWA3|intact:EBI-8645823|intact:MINT-8163548 psi-mi:ubp22_human(display_long)|uniprotkb:Ubiquitin-specific-processing protease 22(gene name synonym)|uniprotkb:Deubiquitinating enzyme 22(gene name synonym)|uniprotkb:USP22(gene name)|psi-mi:USP22(display_short)|uniprotkb:KIAA1063(gene name synonym)|uniprotkb:USP3L(gene name synonym)|uniprotkb:Ubiquitin thioesterase 22(gene name synonym) psi-mi:taf9_human(display_long)|uniprotkb:Transcription initiation factor TFIID 31 kDa subunit(gene name synonym)|uniprotkb:Transcription initiation factor TFIID 32 kDa subunit(gene name synonym)|uniprotkb:RNA polymerase II TBP-associated factor subunit G(gene name synonym)|uniprotkb:STAF31/32(gene name synonym)|uniprotkb:TAF9(gene name)|psi-mi:TAF9(display_short)|uniprotkb:TAF2G(gene name synonym)|uniprotkb:TAFII31(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512240|imex:IM-12079-71 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_056091.1|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|go:"GO:0007049"(cell cycle)|interpro:IPR028889|interpro:IPR038765|mint:Q9UPT9|go:"GO:0008270"(zinc ion binding)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|reactome:R-HSA-3214847|go:"GO:0016574"(histone ubiquitination)|go:"GO:0016578"(histone deubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019899"(enzyme binding)|reactome:R-HSA-5689880|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|ensembl:ENSG00000124422(gene)|ensembl:ENST00000261497(transcript)|go:"GO:0000124"(SAGA complex)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process) ensembl:ENST00000217893(transcript)|ensembl:ENST00000328663(transcript)|ensembl:ENST00000506736(transcript)|ensembl:ENST00000615404(transcript)|ensembl:ENST00000616867(transcript)|ensembl:ENST00000617893(transcript)|go:"GO:0000124"(SAGA complex)|go:"GO:0000125"|go:"GO:0000492"(box C/D snoRNP assembly)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0002039"(p53 binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005669"(transcription factor TFIID complex)|go:"GO:0006352"(DNA-templated transcription, initiation)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016251"(RNA polymerase II general transcription initiation factor activity)|go:"GO:0030914"|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0033276"(transcription factor TFTC complex)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050821"(protein stabilization)|go:"GO:0051117"(ATPase binding)|go:"GO:0060760"(positive regulation of response to cytokine stimulus)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070742"(C2H2 zinc finger domain binding)|go:"GO:0070761"(pre-snoRNP complex)|go:"GO:0071339"(MLL1 complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902166"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|interpro:IPR003162(Transcription factor TAFII-31)|interpro:IPR009072(Histone-fold)|mint:Q16594|rcsb pdb:6F3T|rcsb pdb:6MZC|rcsb pdb:6MZD|rcsb pdb:6MZL|rcsb pdb:6MZM|rcsb pdb:7EDX|rcsb pdb:7EG7|rcsb pdb:7EG8|rcsb pdb:7EG9|rcsb pdb:7EGA|rcsb pdb:7EGB|rcsb pdb:7EGC|rcsb pdb:7EGD|rcsb pdb:7EGE|rcsb pdb:7EGF|rcsb pdb:7EGG|rcsb pdb:7EGI|rcsb pdb:7EGJ|rcsb pdb:7ENA|rcsb pdb:7ENC|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-3214847|reactome:R-HSA-674695|reactome:R-HSA-6804756|reactome:R-HSA-6807505|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-75953|reactome:R-HSA-76042|ensembl:ENSG00000273841(gene)|ensembl:ENSG00000276463(gene)|refseq:NP_001015892.1|refseq:NP_003178.1|dip:DIP-435N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:8n1lOTC7I8dP3RY1IEUtIkJiSXc9606 rogid:Drikn9IwpWQXbTTXGqwf1hlRNE09606 intact-crc:46AE6105F20EC20E|rigid:G/EnPPzh4kUfo1qCim0ykCN+Qqw false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UPT9 uniprotkb:O94864 intact:EBI-723510|ensembl:ENSP00000261497|uniprotkb:A0JNS3|uniprotkb:Q2NLE2|uniprotkb:Q6MZY4|uniprotkb:Q8TBS8|uniprotkb:Q96IW5 intact:EBI-722912|uniprotkb:Q6IB21|uniprotkb:Q9H2T6|uniprotkb:B4E3W3|ensembl:ENSP00000336750 psi-mi:ubp22_human(display_long)|uniprotkb:Ubiquitin-specific-processing protease 22(gene name synonym)|uniprotkb:Deubiquitinating enzyme 22(gene name synonym)|uniprotkb:USP22(gene name)|psi-mi:USP22(display_short)|uniprotkb:KIAA1063(gene name synonym)|uniprotkb:USP3L(gene name synonym)|uniprotkb:Ubiquitin thioesterase 22(gene name synonym) psi-mi:st65g_human(display_long)|uniprotkb:SPTF-associated factor 65 gamma(gene name synonym)|uniprotkb:Suppressor of Ty 7-like(gene name synonym)|uniprotkb:Adenocarcinoma antigen ART1(gene name synonym)|uniprotkb:SUPT7L(gene name)|psi-mi:SUPT7L(display_short)|uniprotkb:KIAA0764(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512240|imex:IM-12079-71 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_056091.1|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|go:"GO:0007049"(cell cycle)|interpro:IPR028889|interpro:IPR038765|mint:Q9UPT9|go:"GO:0008270"(zinc ion binding)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|reactome:R-HSA-3214847|go:"GO:0016574"(histone ubiquitination)|go:"GO:0016578"(histone deubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019899"(enzyme binding)|reactome:R-HSA-5689880|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|ensembl:ENSG00000124422(gene)|ensembl:ENST00000261497(transcript)|go:"GO:0000124"(SAGA complex)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process) refseq:NP_001269658.1|refseq:NP_001269659.1|refseq:NP_001269660.1|refseq:NP_001269661.1|refseq:NP_055675.1|refseq:XP_005264729.1|ensembl:ENSG00000119760(gene)|ensembl:ENST00000337768(transcript)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004402"(histone acetyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0030914"|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051457"(maintenance of protein location in nucleus)|interpro:IPR006565(Bromodomain transcription factor)|interpro:IPR009072(Histone-fold)|interpro:IPR039460|mint:O94864|reactome:R-HSA-3214847 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:8n1lOTC7I8dP3RY1IEUtIkJiSXc9606 rogid:v26YjDoNB/9ekC4xRZEm77Roruw9606 intact-crc:46AE6105F20EC20E|rigid:G/EnPPzh4kUfo1qCim0ykCN+Qqw false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UPT9 uniprotkb:Q14CW9 intact:EBI-723510|ensembl:ENSP00000261497|uniprotkb:A0JNS3|uniprotkb:Q2NLE2|uniprotkb:Q6MZY4|uniprotkb:Q8TBS8|uniprotkb:Q96IW5 intact:EBI-949215|ensembl:ENSP00000374035|ensembl:ENSP00000465614|uniprotkb:Q96N40|uniprotkb:Q9NPU5|uniprotkb:Q8IY68 psi-mi:ubp22_human(display_long)|uniprotkb:Ubiquitin-specific-processing protease 22(gene name synonym)|uniprotkb:Deubiquitinating enzyme 22(gene name synonym)|uniprotkb:USP22(gene name)|psi-mi:USP22(display_short)|uniprotkb:KIAA1063(gene name synonym)|uniprotkb:USP3L(gene name synonym)|uniprotkb:Ubiquitin thioesterase 22(gene name synonym) psi-mi:at7l3_human(display_long)|uniprotkb:ATXN7L3(gene name)|psi-mi:ATXN7L3(display_short)|uniprotkb:SAGA-associated factor 11 homolog(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512240|imex:IM-12079-71 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_056091.1|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|go:"GO:0007049"(cell cycle)|interpro:IPR028889|interpro:IPR038765|mint:Q9UPT9|go:"GO:0008270"(zinc ion binding)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|reactome:R-HSA-3214847|go:"GO:0016574"(histone ubiquitination)|go:"GO:0016578"(histone deubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019899"(enzyme binding)|reactome:R-HSA-5689880|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|ensembl:ENSG00000124422(gene)|ensembl:ENST00000261497(transcript)|go:"GO:0000124"(SAGA complex)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process) ensembl:ENSG00000087152(gene)|ensembl:ENST00000389384(transcript)|ensembl:ENST00000587097(transcript)|go:"GO:0000124"(SAGA complex)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0016578"(histone deubiquitination)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0071819"(DUBm complex)|interpro:IPR013243(SCA7)|interpro:IPR013246(Sgf11, transcriptional regulation)|mint:Q14CW9|rcsb pdb:2KKT|reactome:R-HSA-3214847|refseq:NP_001092303.1|refseq:NP_064603.1|refseq:XP_016880374.1|refseq:XP_016880375.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:8n1lOTC7I8dP3RY1IEUtIkJiSXc9606 rogid:r0Yw6RIZ9DbDlu2xE5hOFPlvk849606 intact-crc:46AE6105F20EC20E|rigid:G/EnPPzh4kUfo1qCim0ykCN+Qqw false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UPT9 uniprotkb:Q8NBE8 intact:EBI-723510|ensembl:ENSP00000261497|uniprotkb:A0JNS3|uniprotkb:Q2NLE2|uniprotkb:Q6MZY4|uniprotkb:Q8TBS8|uniprotkb:Q96IW5 intact:EBI-2512246|ensembl:ENSP00000272797|ensembl:ENSP00000376419|uniprotkb:Q8N9B9|uniprotkb:Q96FT8 psi-mi:ubp22_human(display_long)|uniprotkb:Ubiquitin-specific-processing protease 22(gene name synonym)|uniprotkb:Deubiquitinating enzyme 22(gene name synonym)|uniprotkb:USP22(gene name)|psi-mi:USP22(display_short)|uniprotkb:KIAA1063(gene name synonym)|uniprotkb:USP3L(gene name synonym)|uniprotkb:Ubiquitin thioesterase 22(gene name synonym) psi-mi:klh23_human(display_long)|uniprotkb:KLHL23(gene name)|psi-mi:KLHL23(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512240|imex:IM-12079-71 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_056091.1|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|go:"GO:0007049"(cell cycle)|interpro:IPR028889|interpro:IPR038765|mint:Q9UPT9|go:"GO:0008270"(zinc ion binding)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|reactome:R-HSA-3214847|go:"GO:0016574"(histone ubiquitination)|go:"GO:0016578"(histone deubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019899"(enzyme binding)|reactome:R-HSA-5689880|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|ensembl:ENSG00000124422(gene)|ensembl:ENST00000261497(transcript)|go:"GO:0000124"(SAGA complex)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process) ensembl:ENSG00000213160(gene)|ensembl:ENST00000272797(transcript)|ensembl:ENST00000392647(transcript)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR011705(BTB/Kelch-associated)|interpro:IPR015915(Kelch-type beta propeller)|interpro:IPR017096(Kelch-like protein, gigaxonin)|refseq:NP_001186219.1|refseq:NP_653312.2 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:8n1lOTC7I8dP3RY1IEUtIkJiSXc9606 rogid:KHjH26i26qZE1hlbLvVU+qbSJHk9606 intact-crc:46AE6105F20EC20E|rigid:G/EnPPzh4kUfo1qCim0ykCN+Qqw false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UPT9 uniprotkb:Q9H9A5 intact:EBI-723510|ensembl:ENSP00000261497|uniprotkb:A0JNS3|uniprotkb:Q2NLE2|uniprotkb:Q6MZY4|uniprotkb:Q8TBS8|uniprotkb:Q96IW5 intact:EBI-1054261|uniprotkb:Q9BU30|uniprotkb:Q9H5J7|uniprotkb:Q9H8X1|uniprotkb:Q9H9W0|uniprotkb:Q9HAH3|uniprotkb:Q9UFJ2|uniprotkb:B7Z7L1|uniprotkb:F8WAF2|intact:EBI-2562025|ensembl:ENSP00000330060 psi-mi:ubp22_human(display_long)|uniprotkb:Ubiquitin-specific-processing protease 22(gene name synonym)|uniprotkb:Deubiquitinating enzyme 22(gene name synonym)|uniprotkb:USP22(gene name)|psi-mi:USP22(display_short)|uniprotkb:KIAA1063(gene name synonym)|uniprotkb:USP3L(gene name synonym)|uniprotkb:Ubiquitin thioesterase 22(gene name synonym) psi-mi:cno10_human(display_long)|uniprotkb:CNOT10(gene name)|psi-mi:CNOT10(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512240|imex:IM-12079-71 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_056091.1|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|go:"GO:0007049"(cell cycle)|interpro:IPR028889|interpro:IPR038765|mint:Q9UPT9|go:"GO:0008270"(zinc ion binding)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|reactome:R-HSA-3214847|go:"GO:0016574"(histone ubiquitination)|go:"GO:0016578"(histone deubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019899"(enzyme binding)|reactome:R-HSA-5689880|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|ensembl:ENSG00000124422(gene)|ensembl:ENST00000261497(transcript)|go:"GO:0000124"(SAGA complex)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process) refseq:NP_001243670.1|refseq:NP_056257.1|refseq:NP_001243671.1|ensembl:ENSG00000182973(gene)|ensembl:ENST00000328834(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006402"(mRNA catabolic process)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030014"(CCR4-NOT complex)|go:"GO:0031047"(gene silencing by RNA)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR039740|mint:Q9H9A5|reactome:R-HSA-429947|reactome:R-HSA-6804115|dip:DIP-46839N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:8n1lOTC7I8dP3RY1IEUtIkJiSXc9606 rogid:92BjBXGyxALldfF9AVpP+EFN38k9606 intact-crc:46AE6105F20EC20E|rigid:G/EnPPzh4kUfo1qCim0ykCN+Qqw false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UPT9 uniprotkb:Q9Y4A5 intact:EBI-723510|ensembl:ENSP00000261497|uniprotkb:A0JNS3|uniprotkb:Q2NLE2|uniprotkb:Q6MZY4|uniprotkb:Q8TBS8|uniprotkb:Q96IW5 intact:EBI-399128|uniprotkb:O75218|uniprotkb:Q9Y631|uniprotkb:Q9Y6H4|uniprotkb:A4D265|ensembl:ENSP00000352925 psi-mi:ubp22_human(display_long)|uniprotkb:Ubiquitin-specific-processing protease 22(gene name synonym)|uniprotkb:Deubiquitinating enzyme 22(gene name synonym)|uniprotkb:USP22(gene name)|psi-mi:USP22(display_short)|uniprotkb:KIAA1063(gene name synonym)|uniprotkb:USP3L(gene name synonym)|uniprotkb:Ubiquitin thioesterase 22(gene name synonym) psi-mi:trrap_human(display_long)|uniprotkb:TRRAP(gene name)|psi-mi:TRRAP(display_short)|uniprotkb:PAF400(gene name synonym)|uniprotkb:350/400 kDa PCAF-associated factor(gene name synonym)|uniprotkb:STAF40(gene name synonym)|uniprotkb:Tra1 homolog(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512240|imex:IM-12079-71 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_056091.1|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|go:"GO:0007049"(cell cycle)|interpro:IPR028889|interpro:IPR038765|mint:Q9UPT9|go:"GO:0008270"(zinc ion binding)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|reactome:R-HSA-3214847|go:"GO:0016574"(histone ubiquitination)|go:"GO:0016578"(histone deubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019899"(enzyme binding)|reactome:R-HSA-5689880|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|ensembl:ENSG00000124422(gene)|ensembl:ENST00000261497(transcript)|go:"GO:0000124"(SAGA complex)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process) refseq:NP_003487.1|ensembl:ENSG00000196367(gene)|ensembl:ENST00000359863(transcript)|go:"GO:0000124"(SAGA complex)|go:"GO:0000125"|go:"GO:0000812"(Swr1 complex)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006281"(DNA repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0016310"(phosphorylation)|go:"GO:0016573"(histone acetylation)|go:"GO:0016578"(histone deubiquitination)|go:"GO:0030914"|go:"GO:0033276"(transcription factor TFTC complex)|go:"GO:0035267"(NuA4 histone acetyltransferase complex)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0043968"(histone H2A acetylation)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR003151(PIK-related kinase, FAT)|interpro:IPR003152(PIK-related kinase, FATC)|interpro:IPR011009(Protein kinase-like)|interpro:IPR014009(PIK-related kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR033317|mint:Q9Y4A5|reactome:R-HSA-201722|reactome:R-HSA-3214847|reactome:R-HSA-5689880|refseq:NP_001231509.1|dip:DIP-28149N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:8n1lOTC7I8dP3RY1IEUtIkJiSXc9606 rogid:bGoQLXxMT0zZ0jVW+2s4hUwnBA49606 intact-crc:46AE6105F20EC20E|rigid:G/EnPPzh4kUfo1qCim0ykCN+Qqw false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UPT9 uniprotkb:Q9NPA8 intact:EBI-723510|ensembl:ENSP00000261497|uniprotkb:A0JNS3|uniprotkb:Q2NLE2|uniprotkb:Q6MZY4|uniprotkb:Q8TBS8|uniprotkb:Q96IW5 intact:EBI-719226|uniprotkb:B2RE52|intact:EBI-10972054|uniprotkb:G3V117|ensembl:ENSP00000429986 psi-mi:ubp22_human(display_long)|uniprotkb:Ubiquitin-specific-processing protease 22(gene name synonym)|uniprotkb:Deubiquitinating enzyme 22(gene name synonym)|uniprotkb:USP22(gene name)|psi-mi:USP22(display_short)|uniprotkb:KIAA1063(gene name synonym)|uniprotkb:USP3L(gene name synonym)|uniprotkb:Ubiquitin thioesterase 22(gene name synonym) psi-mi:eny2_human(display_long)|uniprotkb:Enhancer of yellow 2 transcription factor homolog(gene name synonym)|uniprotkb:DC6(orf name)|uniprotkb:ENY2(gene name)|psi-mi:ENY2(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512240|imex:IM-12079-71 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_056091.1|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|go:"GO:0007049"(cell cycle)|interpro:IPR028889|interpro:IPR038765|mint:Q9UPT9|go:"GO:0008270"(zinc ion binding)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|reactome:R-HSA-3214847|go:"GO:0016574"(histone ubiquitination)|go:"GO:0016578"(histone deubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019899"(enzyme binding)|reactome:R-HSA-5689880|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|ensembl:ENSG00000124422(gene)|ensembl:ENST00000261497(transcript)|go:"GO:0000124"(SAGA complex)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process) refseq:NP_001180486.1|refseq:NP_064574.1|go:"GO:0044615"(nuclear pore nuclear basket)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0061179"(negative regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0070390"(transcription export complex 2)|go:"GO:0071819"(DUBm complex)|interpro:IPR018783|interpro:IPR038212|mint:Q9NPA8|rcsb pdb:4DHX|go:"GO:0030374"(nuclear receptor coactivator activity)|reactome:R-HSA-3214847|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0015031"(protein transport)|go:"GO:0016578"(histone deubiquitination)|go:"GO:0016973"("poly(A)+ mRNA export from nucleus")|ensembl:ENSG00000120533(gene)|ensembl:ENST00000521688(transcript)|go:"GO:0000124"(SAGA complex)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006357"(regulation of transcription by RNA polymerase II) psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:8n1lOTC7I8dP3RY1IEUtIkJiSXc9606 rogid:CJmjqxLqgpxrqtvVVFcgxW5nloE9606 intact-crc:46AE6105F20EC20E|rigid:G/EnPPzh4kUfo1qCim0ykCN+Qqw false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UPT9 uniprotkb:A6NNY8 intact:EBI-723510|ensembl:ENSP00000261497|uniprotkb:A0JNS3|uniprotkb:Q2NLE2|uniprotkb:Q6MZY4|uniprotkb:Q8TBS8|uniprotkb:Q96IW5 intact:EBI-2512262|intact:EBI-28988282|ensembl:ENSP00000483631 psi-mi:ubp22_human(display_long)|uniprotkb:Ubiquitin-specific-processing protease 22(gene name synonym)|uniprotkb:Deubiquitinating enzyme 22(gene name synonym)|uniprotkb:USP22(gene name)|psi-mi:USP22(display_short)|uniprotkb:KIAA1063(gene name synonym)|uniprotkb:USP3L(gene name synonym)|uniprotkb:Ubiquitin thioesterase 22(gene name synonym) psi-mi:ubp27_human(display_long)|uniprotkb:USP27X(gene name)|psi-mi:USP27X(display_short)|uniprotkb:USP22L(gene name synonym)|uniprotkb:USP27(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 27(gene name synonym)|uniprotkb:Deubiquitinating enzyme 27(gene name synonym)|uniprotkb:X-linked ubiquitin carboxyl-terminal hydrolase 27(gene name synonym)|uniprotkb:Ubiquitin carboxyl-terminal hydrolase 22-like(gene name synonym)|uniprotkb:Ubiquitin thioesterase 27(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512240|imex:IM-12079-71 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_056091.1|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|go:"GO:0007049"(cell cycle)|interpro:IPR028889|interpro:IPR038765|mint:Q9UPT9|go:"GO:0008270"(zinc ion binding)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|reactome:R-HSA-3214847|go:"GO:0016574"(histone ubiquitination)|go:"GO:0016578"(histone deubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019899"(enzyme binding)|reactome:R-HSA-5689880|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|ensembl:ENSG00000124422(gene)|ensembl:ENST00000261497(transcript)|go:"GO:0000124"(SAGA complex)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process) ensembl:ENSG00000273820(gene)|ensembl:ENST00000621775(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0050821"(protein stabilization)|go:"GO:0061578"(Lys63-specific deubiquitinase activity)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|mint:A6NNY8|refseq:NP_001138545.1|ensembl:ENSP00000483631 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:8n1lOTC7I8dP3RY1IEUtIkJiSXc9606 rogid:8a2mLpB/MpBNttLlpgcl9dTQz/M9606 intact-crc:46AE6105F20EC20E|rigid:G/EnPPzh4kUfo1qCim0ykCN+Qqw false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UPT9 uniprotkb:Q96ES7 intact:EBI-723510|ensembl:ENSP00000261497|uniprotkb:A0JNS3|uniprotkb:Q2NLE2|uniprotkb:Q6MZY4|uniprotkb:Q8TBS8|uniprotkb:Q96IW5 intact:EBI-743117|ensembl:ENSP00000316114|uniprotkb:Q96MF5 psi-mi:ubp22_human(display_long)|uniprotkb:Ubiquitin-specific-processing protease 22(gene name synonym)|uniprotkb:Deubiquitinating enzyme 22(gene name synonym)|uniprotkb:USP22(gene name)|psi-mi:USP22(display_short)|uniprotkb:KIAA1063(gene name synonym)|uniprotkb:USP3L(gene name synonym)|uniprotkb:Ubiquitin thioesterase 22(gene name synonym) psi-mi:sgf29_human(display_long)|uniprotkb:SGF29(gene name)|psi-mi:SGF29(display_short)|uniprotkb:CCDC101(gene name synonym)|uniprotkb:Coiled-coil domain-containing protein 101(gene name synonym)|uniprotkb:SAGA complex-associated factor 29(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512240|imex:IM-12079-71 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_056091.1|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|go:"GO:0007049"(cell cycle)|interpro:IPR028889|interpro:IPR038765|mint:Q9UPT9|go:"GO:0008270"(zinc ion binding)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|reactome:R-HSA-3214847|go:"GO:0016574"(histone ubiquitination)|go:"GO:0016578"(histone deubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019899"(enzyme binding)|reactome:R-HSA-5689880|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|ensembl:ENSG00000124422(gene)|ensembl:ENST00000261497(transcript)|go:"GO:0000124"(SAGA complex)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process) ensembl:ENSG00000176476(gene)|ensembl:ENST00000317058(transcript)|go:"GO:0000124"(SAGA complex)|go:"GO:0005671"(obsolete Ada2/Gcn5/Ada3 transcription activator complex)|go:"GO:0016573"(histone acetylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0035064"(methylated histone binding)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0070461"(SAGA-type complex)|go:"GO:0071169"(establishment of protein localization to chromatin)|interpro:IPR010750(Protein of unknown function DUF1325)|interpro:IPR037802|mint:Q96ES7|rcsb pdb:3LX7|rcsb pdb:3ME9|refseq:NP_612423.1|rcsb pdb:3MEA|rcsb pdb:3MET|rcsb pdb:3MEU|rcsb pdb:3MEV|rcsb pdb:3MEW|rcsb pdb:5C0M|reactome:R-HSA-3214847 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:8n1lOTC7I8dP3RY1IEUtIkJiSXc9606 rogid:4uvy31cdeHtlQ4BHWSOLE8Szkq49606 intact-crc:46AE6105F20EC20E|rigid:G/EnPPzh4kUfo1qCim0ykCN+Qqw false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UPT9 uniprotkb:Q9NRN7 intact:EBI-723510|ensembl:ENSP00000261497|uniprotkb:A0JNS3|uniprotkb:Q2NLE2|uniprotkb:Q6MZY4|uniprotkb:Q8TBS8|uniprotkb:Q96IW5 intact:EBI-740884|ensembl:ENSP00000278618|uniprotkb:Q9C068|uniprotkb:Q9P0Q3|uniprotkb:Q9UG80|uniprotkb:Q9Y389|uniprotkb:B2R6D1|uniprotkb:B4DDW7 psi-mi:ubp22_human(display_long)|uniprotkb:Ubiquitin-specific-processing protease 22(gene name synonym)|uniprotkb:Deubiquitinating enzyme 22(gene name synonym)|uniprotkb:USP22(gene name)|psi-mi:USP22(display_short)|uniprotkb:KIAA1063(gene name synonym)|uniprotkb:USP3L(gene name synonym)|uniprotkb:Ubiquitin thioesterase 22(gene name synonym) psi-mi:adppt_human(display_long)|uniprotkb:4'-phosphopantetheinyl transferase(gene name synonym)|uniprotkb:Alpha-aminoadipic semialdehyde dehydrogenase-phosphopantetheinyl transferase(gene name synonym)|uniprotkb:LYS5 ortholog(gene name synonym)|uniprotkb:AASDHPPT(gene name)|psi-mi:AASDHPPT(display_short)|uniprotkb:CGI-80(orf name)|uniprotkb:HAH-P(orf name)|uniprotkb:HSPC223(orf name)|uniprotkb:x0005(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512240|imex:IM-12079-71 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_056091.1|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|go:"GO:0007049"(cell cycle)|interpro:IPR028889|interpro:IPR038765|mint:Q9UPT9|go:"GO:0008270"(zinc ion binding)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|reactome:R-HSA-3214847|go:"GO:0016574"(histone ubiquitination)|go:"GO:0016578"(histone deubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019899"(enzyme binding)|reactome:R-HSA-5689880|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|ensembl:ENSG00000124422(gene)|ensembl:ENST00000261497(transcript)|go:"GO:0000124"(SAGA complex)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process) refseq:NP_056238.2|ensembl:ENSG00000149313(gene)|ensembl:ENST00000278618(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0005829"(cytosol)|go:"GO:0008897"(holo-[acyl-carrier-protein] synthase activity)|go:"GO:0015939"(pantothenate metabolic process)|go:"GO:0019878"(lysine biosynthetic process via aminoadipic acid)|go:"GO:0070062"(extracellular exosome)|interpro:IPR008278(4'-phosphopantetheinyl transferase)|interpro:IPR037143|rcsb pdb:2BYD|rcsb pdb:2C43|rcsb pdb:2CG5|reactome:R-HSA-199220 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:8n1lOTC7I8dP3RY1IEUtIkJiSXc9606 rogid:0S9gDK0HeJ+8eoM5vHaJDW3THAY9606 intact-crc:46AE6105F20EC20E|rigid:G/EnPPzh4kUfo1qCim0ykCN+Qqw false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UPT9 uniprotkb:O75618 intact:EBI-723510|ensembl:ENSP00000261497|uniprotkb:A0JNS3|uniprotkb:Q2NLE2|uniprotkb:Q6MZY4|uniprotkb:Q8TBS8|uniprotkb:Q96IW5 intact:EBI-1043164|uniprotkb:O60737|ensembl:ENSP00000356985|ensembl:ENSP00000414821|ensembl:ENSP00000445835|ensembl:ENSP00000476946|uniprotkb:D3DVF5 psi-mi:ubp22_human(display_long)|uniprotkb:Ubiquitin-specific-processing protease 22(gene name synonym)|uniprotkb:Deubiquitinating enzyme 22(gene name synonym)|uniprotkb:USP22(gene name)|psi-mi:USP22(display_short)|uniprotkb:KIAA1063(gene name synonym)|uniprotkb:USP3L(gene name synonym)|uniprotkb:Ubiquitin thioesterase 22(gene name synonym) psi-mi:dedd_human(display_long)|uniprotkb:DEDPro1(gene name synonym)|uniprotkb:Death effector domain-containing testicular molecule(gene name synonym)|uniprotkb:FLDED-1(gene name synonym)|uniprotkb:DEDD(gene name)|psi-mi:DEDD(display_short)|uniprotkb:DEDPRO1(gene name synonym)|uniprotkb:DEFT(gene name synonym)|uniprotkb:KE05(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512240|imex:IM-12079-71 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_056091.1|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|go:"GO:0007049"(cell cycle)|interpro:IPR028889|interpro:IPR038765|mint:Q9UPT9|go:"GO:0008270"(zinc ion binding)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|reactome:R-HSA-3214847|go:"GO:0016574"(histone ubiquitination)|go:"GO:0016578"(histone deubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019899"(enzyme binding)|reactome:R-HSA-5689880|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|ensembl:ENSG00000124422(gene)|ensembl:ENST00000261497(transcript)|go:"GO:0000124"(SAGA complex)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process) go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0046697"(decidualization)|go:"GO:1901837"(negative regulation of transcription of nucleolar large rRNA by RNA polymerase I)|interpro:IPR001875(Death effector)|interpro:IPR011029(DEATH-like)|interpro:IPR038856|mint:O75618|ensembl:ENSG00000158796(gene)|ensembl:ENST00000368006(transcript)|ensembl:ENST00000458050(transcript)|ensembl:ENST00000490843(transcript)|ensembl:ENST00000545495(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007283"(spermatogenesis)|refseq:NP_001034800.1|refseq:NP_001034801.1|refseq:NP_127491.1|refseq:XP_016858291.1|dip:DIP-41944N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:8n1lOTC7I8dP3RY1IEUtIkJiSXc9606 rogid:wcUMlOrbLzoDvmFg6ZjigXLSB1Y9606 intact-crc:46AE6105F20EC20E|rigid:G/EnPPzh4kUfo1qCim0ykCN+Qqw false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UPT9 uniprotkb:Q4J6C6 intact:EBI-723510|ensembl:ENSP00000261497|uniprotkb:A0JNS3|uniprotkb:Q2NLE2|uniprotkb:Q6MZY4|uniprotkb:Q8TBS8|uniprotkb:Q96IW5 intact:EBI-949331|uniprotkb:A7E2X6|uniprotkb:O43163|uniprotkb:Q4J6C3|uniprotkb:Q4J6C4|uniprotkb:Q4ZG39|uniprotkb:Q6ZMW7|uniprotkb:Q96DW7|uniprotkb:D6W5A3|ensembl:ENSP00000260648|ensembl:ENSP00000386509|ensembl:ENSP00000386543|ensembl:ENSP00000386909|ensembl:ENSP00000391456|ensembl:ENSP00000409480 psi-mi:ubp22_human(display_long)|uniprotkb:Ubiquitin-specific-processing protease 22(gene name synonym)|uniprotkb:Deubiquitinating enzyme 22(gene name synonym)|uniprotkb:USP22(gene name)|psi-mi:USP22(display_short)|uniprotkb:KIAA1063(gene name synonym)|uniprotkb:USP3L(gene name synonym)|uniprotkb:Ubiquitin thioesterase 22(gene name synonym) psi-mi:ppcel_human(display_long)|uniprotkb:KIAA0436(gene name synonym)|uniprotkb:Prolylendopeptidase-like(gene name synonym)|uniprotkb:PREPL(gene name)|psi-mi:PREPL(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512240|imex:IM-12079-71 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_056091.1|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|go:"GO:0007049"(cell cycle)|interpro:IPR028889|interpro:IPR038765|mint:Q9UPT9|go:"GO:0008270"(zinc ion binding)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|reactome:R-HSA-3214847|go:"GO:0016574"(histone ubiquitination)|go:"GO:0016578"(histone deubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019899"(enzyme binding)|reactome:R-HSA-5689880|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|ensembl:ENSG00000124422(gene)|ensembl:ENST00000261497(transcript)|go:"GO:0000124"(SAGA complex)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process) refseq:NP_001035844.1|refseq:NP_001035845.1|refseq:NP_001165074.1|refseq:NP_001165077.1|refseq:NP_001165084.1|refseq:NP_001165088.1|refseq:NP_006027.2|refseq:XP_011531500.1|refseq:XP_011531502.1|refseq:XP_011531504.1|refseq:XP_016860873.1|refseq:XP_016860874.1|ensembl:ENSG00000138078(gene)|ensembl:ENST00000260648(transcript)|ensembl:ENST00000409272(transcript)|ensembl:ENST00000409936(transcript)|ensembl:ENST00000410081(transcript)|ensembl:ENST00000425263(transcript)|ensembl:ENST00000426481(transcript)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0008233"(peptidase activity)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR001375(Peptidase S9, prolyl oligopeptidase active site region)|interpro:IPR002470(Peptidase S9A, prolyl oligopeptidase)|interpro:IPR023302|interpro:IPR029058 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:8n1lOTC7I8dP3RY1IEUtIkJiSXc9606 rogid:xn++9zR6AX/HzP4KzrriJR5IUTk9606 intact-crc:46AE6105F20EC20E|rigid:G/EnPPzh4kUfo1qCim0ykCN+Qqw false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UPT9 uniprotkb:O75486 intact:EBI-723510|ensembl:ENSP00000261497|uniprotkb:A0JNS3|uniprotkb:Q2NLE2|uniprotkb:Q6MZY4|uniprotkb:Q8TBS8|uniprotkb:Q96IW5 intact:EBI-896640|uniprotkb:A6NKG9|uniprotkb:O76066|uniprotkb:Q5TAV9|uniprotkb:B2R9Q5|uniprotkb:Q86VN7|intact:EBI-11061133|ensembl:ENSP00000360514|ensembl:ENSP00000436411 psi-mi:ubp22_human(display_long)|uniprotkb:Ubiquitin-specific-processing protease 22(gene name synonym)|uniprotkb:Deubiquitinating enzyme 22(gene name synonym)|uniprotkb:USP22(gene name)|psi-mi:USP22(display_short)|uniprotkb:KIAA1063(gene name synonym)|uniprotkb:USP3L(gene name synonym)|uniprotkb:Ubiquitin thioesterase 22(gene name synonym) psi-mi:supt3_human(display_long)|uniprotkb:SUPT3H(gene name)|psi-mi:SUPT3H(display_short)|uniprotkb:SPT3(gene name synonym)|uniprotkb:SPT3-like protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512240|imex:IM-12079-71 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_056091.1|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|go:"GO:0007049"(cell cycle)|interpro:IPR028889|interpro:IPR038765|mint:Q9UPT9|go:"GO:0008270"(zinc ion binding)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|reactome:R-HSA-3214847|go:"GO:0016574"(histone ubiquitination)|go:"GO:0016578"(histone deubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019899"(enzyme binding)|reactome:R-HSA-5689880|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|ensembl:ENSG00000124422(gene)|ensembl:ENST00000261497(transcript)|go:"GO:0000124"(SAGA complex)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process) refseq:XP_016866861.1|refseq:NP_003590.1|refseq:NP_852001.1|refseq:XP_016866860.1|dip:DIP-28148N|ensembl:ENSG00000196284(gene)|ensembl:ENST00000371459(transcript)|ensembl:ENST00000475057(transcript)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0016578"(histone deubiquitination)|go:"GO:0030914"|go:"GO:0033276"(transcription factor TFTC complex)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046982"(protein heterodimerization activity)|interpro:IPR003195(Transcription initiation factor IID, 18 kDa subunit)|interpro:IPR009072(Histone-fold)|mint:O75486|reactome:R-HSA-3214847 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:8n1lOTC7I8dP3RY1IEUtIkJiSXc9606 rogid:P+62Ufs6GyoQYKCpbNaab5KzYOc9606 intact-crc:46AE6105F20EC20E|rigid:G/EnPPzh4kUfo1qCim0ykCN+Qqw false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UPT9 uniprotkb:Q2M1P5 intact:EBI-723510|ensembl:ENSP00000261497|uniprotkb:A0JNS3|uniprotkb:Q2NLE2|uniprotkb:Q6MZY4|uniprotkb:Q8TBS8|uniprotkb:Q96IW5 intact:EBI-2512228|ensembl:ENSP00000377934|uniprotkb:Q3SXY0|uniprotkb:Q6UXE9|uniprotkb:Q8IW72 psi-mi:ubp22_human(display_long)|uniprotkb:Ubiquitin-specific-processing protease 22(gene name synonym)|uniprotkb:Deubiquitinating enzyme 22(gene name synonym)|uniprotkb:USP22(gene name)|psi-mi:USP22(display_short)|uniprotkb:KIAA1063(gene name synonym)|uniprotkb:USP3L(gene name synonym)|uniprotkb:Ubiquitin thioesterase 22(gene name synonym) psi-mi:kif7_human(display_long)|uniprotkb:KIF7(gene name)|psi-mi:KIF7(display_short)|uniprotkb:UNQ340/PRO539(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512240|imex:IM-12079-71 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_056091.1|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|go:"GO:0007049"(cell cycle)|interpro:IPR028889|interpro:IPR038765|mint:Q9UPT9|go:"GO:0008270"(zinc ion binding)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|reactome:R-HSA-3214847|go:"GO:0016574"(histone ubiquitination)|go:"GO:0016578"(histone deubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019899"(enzyme binding)|reactome:R-HSA-5689880|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|ensembl:ENSG00000124422(gene)|ensembl:ENST00000261497(transcript)|go:"GO:0000124"(SAGA complex)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process) ensembl:ENSG00000166813(gene)|ensembl:ENST00000394412(transcript)|go:"GO:0003777"(microtubule motor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|go:"GO:0005929"(cilium)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0008017"(microtubule binding)|go:"GO:0036064"(ciliary basal body)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0097542"(ciliary tip)|go:"GO:1990939"|interpro:IPR001752(Kinesin, motor region)|interpro:IPR019821|interpro:IPR027417|interpro:IPR036961|mint:Q2M1P5|rcsb pdb:2XT3|rcsb pdb:4A14|rcsb pdb:6MLQ|rcsb pdb:6MLR|reactome:R-HSA-5610787|reactome:R-HSA-5632684|refseq:NP_940927.2 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:8n1lOTC7I8dP3RY1IEUtIkJiSXc9606 rogid:yEZWFId7u3KkCdclCbZNeAZS1B49606 intact-crc:46AE6105F20EC20E|rigid:G/EnPPzh4kUfo1qCim0ykCN+Qqw false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96RU2 uniprotkb:Q12888 intact:EBI-2512342|ensembl:ENSP00000003302|uniprotkb:B0YJC0|uniprotkb:B0YJC1|uniprotkb:Q9P213|intact:EBI-2796288|uniprotkb:Q6NZX9 intact:EBI-396540|uniprotkb:Q2M1Z7|uniprotkb:Q4LE46|uniprotkb:Q5FWZ3|uniprotkb:Q7Z3U4|ensembl:ENSP00000263801|uniprotkb:F8VY86 psi-mi:ubp28_human(display_long)|uniprotkb:USP28(gene name)|psi-mi:USP28(display_short)|uniprotkb:KIAA1515(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 28(gene name synonym)|uniprotkb:Deubiquitinating enzyme 28(gene name synonym)|uniprotkb:Ubiquitin thioesterase 28(gene name synonym) psi-mi:tp53b_human(display_long)|uniprotkb:TP53BP1(gene name)|psi-mi:TP53BP1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512337|imex:IM-12079-21 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000048028(gene)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008283"(cell population proliferation)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034644"(cellular response to UV)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR009060(UBA-like)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|mint:Q96RU2|rcsb pdb:2LVA|rcsb pdb:2MUU|rcsb pdb:6H4H|rcsb pdb:6H4I|rcsb pdb:6HEH|rcsb pdb:6HEI|rcsb pdb:6HEJ|rcsb pdb:6HEK|reactome:R-HSA-5689880|ensembl:ENST00000003302(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|refseq:NP_065937.1|refseq:NP_001333187.1|refseq:NP_001333202.1 refseq:NP_001135451.1|refseq:NP_001135452.1|refseq:NP_005648.1|go:"GO:0045830"(positive regulation of isotype switching)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0042393"(histone binding)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061649"(ubiquitin modification-dependent histone binding)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:1990391"(DNA repair complex)|go:"GO:2000042"(negative regulation of double-strand break repair via homologous recombination)|interpro:IPR001357(BRCT)|interpro:IPR002999(Tudor)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR015125(Tumour suppressor p53-binding protein-1 Tudor)|interpro:IPR036420|mint:Q12888|reactome:R-HSA-5693607|reactome:R-HSA-69473|rcsb pdb:1GZH|rcsb pdb:1KZY|rcsb pdb:1XNI|rcsb pdb:2G3R|rcsb pdb:2IG0|rcsb pdb:2LVM|rcsb pdb:2MWO|rcsb pdb:2MWP|rcsb pdb:3LGF|rcsb pdb:3LGL|rcsb pdb:3LH0|rcsb pdb:4CRI|rcsb pdb:4RG2|rcsb pdb:4X34|rcsb pdb:5ECG|rcsb pdb:5J26|rcsb pdb:5KGF|rcsb pdb:5Z78|rcsb pdb:5ZCJ|rcsb pdb:6CO1|rcsb pdb:6CO2|rcsb pdb:6IU7|rcsb pdb:6IUA|rcsb pdb:6MXX|rcsb pdb:6MXY|rcsb pdb:6MXZ|rcsb pdb:6MY0|rcsb pdb:6RML|rcsb pdb:6RMM|rcsb pdb:6UPT|rcsb pdb:6VA5|rcsb pdb:6VIP|rcsb pdb:7LIN|rcsb pdb:7LIO|reactome:R-HSA-3232118|reactome:R-HSA-5693565|reactome:R-HSA-5693571|ensembl:ENSG00000067369(gene)|ensembl:ENST00000263801(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000776"(kinetochore)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0002039"(p53 binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005737"(cytoplasm)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016604"(nuclear body)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042162"(telomeric DNA binding)|dip:DIP-5978N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:axlPKHiS0KlPbl2dNx2h12/LtY09606 rogid:QRksPL7aJniN+0thiLfIdeythoU9606 intact-crc:F0040B384DD9AA8E|rigid:gddXQRYoooqBQLJqp+Q7h3K3bA8 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96RU2 uniprotkb:P61956 intact:EBI-2512342|ensembl:ENSP00000003302|uniprotkb:B0YJC0|uniprotkb:B0YJC1|uniprotkb:Q9P213|intact:EBI-2796288|uniprotkb:Q6NZX9 intact:EBI-473220|uniprotkb:P55855|uniprotkb:Q6IPZ6|ensembl:ENSP00000405965|uniprotkb:Q32Q42|uniprotkb:Q96HK1|intact:EBI-2512339|uniprotkb:B2R4I2 psi-mi:ubp28_human(display_long)|uniprotkb:USP28(gene name)|psi-mi:USP28(display_short)|uniprotkb:KIAA1515(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 28(gene name synonym)|uniprotkb:Deubiquitinating enzyme 28(gene name synonym)|uniprotkb:Ubiquitin thioesterase 28(gene name synonym) psi-mi:sumo2_human(display_long)|uniprotkb:SMT3 homolog 2(gene name synonym)|uniprotkb:Sentrin-2(gene name synonym)|uniprotkb:HSMT3(gene name synonym)|uniprotkb:SUMO-3(gene name synonym)|uniprotkb:SUMO2(gene name)|psi-mi:SUMO2(display_short)|uniprotkb:SMT3H2(gene name synonym)|uniprotkb:SMT3B(gene name synonym)|uniprotkb:Ubiquitin-like protein SMT3B(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512337|imex:IM-12079-21 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000048028(gene)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008283"(cell population proliferation)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034644"(cellular response to UV)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR009060(UBA-like)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|mint:Q96RU2|rcsb pdb:2LVA|rcsb pdb:2MUU|rcsb pdb:6H4H|rcsb pdb:6H4I|rcsb pdb:6HEH|rcsb pdb:6HEI|rcsb pdb:6HEJ|rcsb pdb:6HEK|reactome:R-HSA-5689880|ensembl:ENST00000003302(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|refseq:NP_065937.1|refseq:NP_001333187.1|refseq:NP_001333202.1 rcsb pdb:1Z5Q|rcsb pdb:2AWT|rcsb pdb:2CKH|rcsb pdb:2D07|go:"GO:0016605"(PML body)|go:"GO:0016925"(protein sumoylation)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0031386"(protein tag)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|interpro:IPR000626(Ubiquitin)|interpro:IPR022617|interpro:IPR029071|mint:P61956|rcsb pdb:1WM2|rcsb pdb:1WM3|rcsb pdb:1WZ0|rcsb pdb:2IO0|ensembl:ENSG00000188612(gene)|ensembl:ENST00000420826(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|refseq:NP_001005849.1|refseq:NP_008868.3|rcsb pdb:2IO3|rcsb pdb:6JXW|rcsb pdb:6JXX|reactome:R-HSA-196791|reactome:R-HSA-3065676|reactome:R-HSA-3065678|reactome:R-HSA-3065679|reactome:R-HSA-3108214|reactome:R-HSA-3232118|reactome:R-HSA-3899300|reactome:R-HSA-4085377|reactome:R-HSA-4090294|reactome:R-HSA-4551638|reactome:R-HSA-4570464|reactome:R-HSA-4615885|reactome:R-HSA-5693607|reactome:R-HSA-5696395|rcsb pdb:5GHC|rcsb pdb:5D2M|rcsb pdb:5ELU|rcsb pdb:5EQL|rcsb pdb:5GHB|rcsb pdb:2IYD|rcsb pdb:2N1W|rcsb pdb:2N9E|rcsb pdb:2RPQ|rcsb pdb:3UIN|rcsb pdb:3UIO|rcsb pdb:3ZO5|rcsb pdb:4BKG|rcsb pdb:4NPN|dip:DIP-29253N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:axlPKHiS0KlPbl2dNx2h12/LtY09606 rogid:WgudlZhwtQbQInv29BniecTYGY89606 intact-crc:F0040B384DD9AA8E|rigid:gddXQRYoooqBQLJqp+Q7h3K3bA8 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96RU2 uniprotkb:O60306 intact:EBI-2512342|ensembl:ENSP00000003302|uniprotkb:B0YJC0|uniprotkb:B0YJC1|uniprotkb:Q9P213|intact:EBI-2796288|uniprotkb:Q6NZX9 intact:EBI-2512328|ensembl:ENSP00000156471|uniprotkb:Q2YDX9|uniprotkb:Q6PIC8|uniprotkb:Q6IRU8|uniprotkb:A0JP17|uniprotkb:A5YKK3 psi-mi:ubp28_human(display_long)|uniprotkb:USP28(gene name)|psi-mi:USP28(display_short)|uniprotkb:KIAA1515(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 28(gene name synonym)|uniprotkb:Deubiquitinating enzyme 28(gene name synonym)|uniprotkb:Ubiquitin thioesterase 28(gene name synonym) psi-mi:aqr_human(display_long)|uniprotkb:AQR(gene name)|psi-mi:AQR(display_short)|uniprotkb:KIAA0560(gene name synonym)|uniprotkb:Intron-binding protein of 160 kDa(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512337|imex:IM-12079-21 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000048028(gene)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008283"(cell population proliferation)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034644"(cellular response to UV)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR009060(UBA-like)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|mint:Q96RU2|rcsb pdb:2LVA|rcsb pdb:2MUU|rcsb pdb:6H4H|rcsb pdb:6H4I|rcsb pdb:6HEH|rcsb pdb:6HEI|rcsb pdb:6HEJ|rcsb pdb:6HEK|reactome:R-HSA-5689880|ensembl:ENST00000003302(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|refseq:NP_065937.1|refseq:NP_001333187.1|refseq:NP_001333202.1 ensembl:ENSG00000021776(gene)|ensembl:ENST00000156471(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0016020"(membrane)|go:"GO:0034458"(3'-5' RNA helicase activity)|go:"GO:0071007"(U2-type catalytic step 2 spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR026300|interpro:IPR027417|interpro:IPR032174|interpro:IPR041677|interpro:IPR041679|mint:O60306|rcsb pdb:4PJ3|rcsb pdb:5MQF|rcsb pdb:5XJC|rcsb pdb:5YZG|rcsb pdb:5Z56|rcsb pdb:5Z57|rcsb pdb:6FF7|rcsb pdb:6ICZ|rcsb pdb:6ID0|rcsb pdb:6ID1|rcsb pdb:6QDV|rcsb pdb:7A5P|rcsb pdb:7ABI|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-72163|refseq:NP_055506.1|dip:DIP-53576N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:axlPKHiS0KlPbl2dNx2h12/LtY09606 rogid:ZkD96by9PXxdrXPBXE+ZTaZeGnM9606 intact-crc:F0040B384DD9AA8E|rigid:gddXQRYoooqBQLJqp+Q7h3K3bA8 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75604 uniprotkb:P36776 intact:EBI-743272|uniprotkb:Q96MB9|uniprotkb:Q9BQ21|ensembl:ENSP00000260187|uniprotkb:Q8IW04|uniprotkb:Q8IUM2|uniprotkb:B0YJB8|uniprotkb:E9PPM2 intact:EBI-357448|ensembl:ENSP00000353826|intact:EBI-1054513|uniprotkb:D6W635|uniprotkb:E5KMH8|uniprotkb:P36777|uniprotkb:Q8N8K8|uniprotkb:Q9UQ95|uniprotkb:B3KPH8|uniprotkb:F5GZ27|intact:EBI-10964236 psi-mi:ubp2_human(display_long)|uniprotkb:Ubiquitin-specific-processing protease 2(gene name synonym)|uniprotkb:Deubiquitinating enzyme 2(gene name synonym)|uniprotkb:41 kDa ubiquitin-specific protease(gene name synonym)|uniprotkb:USP2(gene name)|psi-mi:USP2(display_short)|uniprotkb:UBP41(gene name synonym)|uniprotkb:Ubiquitin thioesterase 2(gene name synonym) psi-mi:lonm_human(display_long)|uniprotkb:LONHs(gene name synonym)|uniprotkb:PRSS15(gene name synonym)|uniprotkb:LONP1(gene name)|psi-mi:LONP1(display_short)|uniprotkb:Lon protease-like protein(gene name synonym)|uniprotkb:Mitochondrial ATP-dependent protease Lon(gene name synonym)|uniprotkb:Serine protease 15(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512362|imex:IM-12079-72 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004196.4|refseq:NP_741994.1|ensembl:ENSG00000036672(gene)|ensembl:ENST00000260187(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007049"(cell cycle)|go:"GO:0007517"(muscle organ development)|go:"GO:0016020"(membrane)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042802"(identical protein binding)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048512"(circadian behavior)|go:"GO:0050821"(protein stabilization)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|go:"GO:0030332"(cyclin binding)|interpro:IPR028889|interpro:IPR038765|mint:O75604|rcsb pdb:2HD5|rcsb pdb:2IBI|rcsb pdb:3NHE|rcsb pdb:3V6C|rcsb pdb:3V6E|rcsb pdb:5XU8|rcsb pdb:5XVE|rcsb pdb:6DGF|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5689880|reactome:R-HSA-6804757|refseq:NP_001230688.1|refseq:XP_005271778.1|refseq:XP_005271779.1|dip:DIP-29134N refseq:NP_001263408.1|go:"GO:0070407"(oxidation-dependent protein catabolic process)|interpro:IPR003111(Peptidase S16, lon N-terminal)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|interpro:IPR004815(Peptidase S16, ATP-dependent protease La)|interpro:IPR008268(Peptidase S16, active site)|interpro:IPR008269(Peptidase S16, lon C-terminal)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR015947(PUA-like)|interpro:IPR020568|interpro:IPR027065|interpro:IPR027417|interpro:IPR027503|mint:P36776|rcsb pdb:2X36|go:"GO:0051880"(G-quadruplex DNA binding)|go:"GO:0070182"(DNA polymerase binding)|rcsb pdb:6WYS|rcsb pdb:6WZV|rcsb pdb:6X1M|rcsb pdb:6X27|rcsb pdb:7KRZ|rcsb pdb:7KSL|rcsb pdb:7KSM|rcsb pdb:7NFY|rcsb pdb:7NG4|rcsb pdb:7NG5|rcsb pdb:7NGC|rcsb pdb:7NGF|rcsb pdb:7NGL|rcsb pdb:7NGP|rcsb pdb:7NGQ|ensembl:ENSG00000196365(gene)|ensembl:ENST00000360614(transcript)|go:"GO:0000002"(mitochondrial genome maintenance)|go:"GO:0001018"(mitochondrial promoter sequence-specific DNA binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0004176"(ATP-dependent peptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007568"(aging)|go:"GO:0009725"(response to hormone)|go:"GO:0010044"(response to aluminum ion)|go:"GO:0016020"(membrane)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0032042"(mitochondrial DNA metabolic process)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0042802"(identical protein binding)|go:"GO:0043531"(ADP binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|refseq:NP_001263409.1|refseq:NP_004784.2 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:ILcDPhStrk+aUeVZ4y3yR4B/4y49606 rogid:quAPz1dZK2XdoE6WMjQJwFtx53o9606 intact-crc:CA993A5A626738E0|rigid:MijJBug7pdxpM15ZKAiZXKKozQE false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O75604 uniprotkb:Q9Y3B9 intact:EBI-743272|uniprotkb:Q96MB9|uniprotkb:Q9BQ21|ensembl:ENSP00000260187|uniprotkb:Q8IW04|uniprotkb:Q8IUM2|uniprotkb:B0YJB8|uniprotkb:E9PPM2 intact:EBI-1055610|intact:EBI-28979625|ensembl:ENSP00000355899 psi-mi:ubp2_human(display_long)|uniprotkb:Ubiquitin-specific-processing protease 2(gene name synonym)|uniprotkb:Deubiquitinating enzyme 2(gene name synonym)|uniprotkb:41 kDa ubiquitin-specific protease(gene name synonym)|uniprotkb:USP2(gene name)|psi-mi:USP2(display_short)|uniprotkb:UBP41(gene name synonym)|uniprotkb:Ubiquitin thioesterase 2(gene name synonym) psi-mi:rrp15_human(display_long)|uniprotkb:Ribosomal RNA-processing protein 15(gene name synonym)|uniprotkb:RRP15(gene name)|psi-mi:RRP15(display_short)|uniprotkb:KIAA0507(gene name synonym)|uniprotkb:CGI-115(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512362|imex:IM-12079-72 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004196.4|refseq:NP_741994.1|ensembl:ENSG00000036672(gene)|ensembl:ENST00000260187(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007049"(cell cycle)|go:"GO:0007517"(muscle organ development)|go:"GO:0016020"(membrane)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042802"(identical protein binding)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048512"(circadian behavior)|go:"GO:0050821"(protein stabilization)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|go:"GO:0030332"(cyclin binding)|interpro:IPR028889|interpro:IPR038765|mint:O75604|rcsb pdb:2HD5|rcsb pdb:2IBI|rcsb pdb:3NHE|rcsb pdb:3V6C|rcsb pdb:3V6E|rcsb pdb:5XU8|rcsb pdb:5XVE|rcsb pdb:6DGF|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5689880|reactome:R-HSA-6804757|refseq:NP_001230688.1|refseq:XP_005271778.1|refseq:XP_005271779.1|dip:DIP-29134N ensembl:ENSP00000355899|refseq:NP_057136.2|ensembl:ENSG00000067533(gene)|ensembl:ENST00000366932(transcript)|go:"GO:0000460"(maturation of 5.8S rRNA)|go:"GO:0000470"(maturation of LSU-rRNA)|go:"GO:0030687"(preribosome, large subunit precursor)|interpro:IPR012459(Protein of unknown function DUF1665) psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:ILcDPhStrk+aUeVZ4y3yR4B/4y49606 rogid:EJQFG76HKEYeJ6LwFd5zaUmoScw9606 intact-crc:CA993A5A626738E0|rigid:MijJBug7pdxpM15ZKAiZXKKozQE false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q70CQ3 uniprotkb:Q15459 intact:EBI-2512374|ensembl:ENSP00000257548|uniprotkb:Q9BSS3|uniprotkb:Q96JX4|uniprotkb:Q8WTU7 intact:EBI-1054743|uniprotkb:E9PAW1|ensembl:ENSP00000215793 psi-mi:ubp30_human(display_long)|uniprotkb:USP30(gene name)|psi-mi:USP30(display_short)|uniprotkb:Ubiquitin-specific-processing protease 30(gene name synonym)|uniprotkb:Deubiquitinating enzyme 30(gene name synonym)|uniprotkb:Ubiquitin thioesterase 30(gene name synonym) psi-mi:sf3a1_human(display_long)|uniprotkb:Spliceosome-associated protein 114(gene name synonym)|uniprotkb:SF3a120(gene name synonym)|uniprotkb:SF3A1(gene name)|psi-mi:SF3A1(display_short)|uniprotkb:SAP114(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512385|imex:IM-12079-22 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000135093(gene)|ensembl:ENST00000257548(transcript)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000425"(pexophagy)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008053"(mitochondrial fusion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035871"(protein K11-linked deubiquitination)|go:"GO:0044313"(protein K6-linked deubiquitination)|go:"GO:0101005"(deubiquitinase activity)|go:"GO:1901525"(negative regulation of mitophagy)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|rcsb pdb:5OHK|rcsb pdb:5OHN|rcsb pdb:5OHP|reactome:R-HSA-5689880|reactome:R-HSA-9664873|refseq:NP_001288104.1|refseq:NP_116052.2|refseq:XP_006719716.1|dip:DIP-53578N refseq:NP_005868.1|ensembl:ENSG00000099995(gene)|ensembl:ENST00000215793(transcript)|go:"GO:0000389"(mRNA 3'-splice site recognition)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005684"(U2-type spliceosomal complex)|go:"GO:0005686"(U2 snRNP)|go:"GO:0006397"(mRNA processing)|go:"GO:0016607"(nuclear speck)|rcsb pdb:2DT6|go:"GO:0071004"(U2-type prespliceosome)|rcsb pdb:2DT7|rcsb pdb:5Z56|rcsb pdb:5Z57|rcsb pdb:5Z58|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6FF7|rcsb pdb:6QX9|go:"GO:0071005"(U2-type precatalytic spliceosome)|rcsb pdb:6Y53|rcsb pdb:6Y5Q|rcsb pdb:7ABG|rcsb pdb:7ABI|reactome:R-HSA-72163|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:1903241"(U2-type prespliceosome assembly)|interpro:IPR000061(SWAP/Surp)|interpro:IPR000626(Ubiquitin)|interpro:IPR022030|interpro:IPR029071|interpro:IPR035563|interpro:IPR035967|mint:Q15459|rcsb pdb:1ZKH|dip:DIP-29164N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:KWb+QBK14roR0XS+MQNdf60cO4w9606 rogid:YrIs3RwfjUcDsHCJDgTLMnOUJZM9606 intact-crc:E042755C6E22D33B|rigid:dHch+1JJsDENhffBRpKIjQHQKMU false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q70CQ3 uniprotkb:W4VSR2 intact:EBI-2512374|ensembl:ENSP00000257548|uniprotkb:Q9BSS3|uniprotkb:Q96JX4|uniprotkb:Q8WTU7 intact:EBI-2512381|ensembl:ENSP00000471735 psi-mi:ubp30_human(display_long)|uniprotkb:USP30(gene name)|psi-mi:USP30(display_short)|uniprotkb:Ubiquitin-specific-processing protease 30(gene name synonym)|uniprotkb:Deubiquitinating enzyme 30(gene name synonym)|uniprotkb:Ubiquitin thioesterase 30(gene name synonym) psi-mi:w4vsr2_human(display_long)|uniprotkb:MPND(gene name)|psi-mi:MPND(display_short)|uniprotkb:FLJ14981(gene name synonym)|uniprotkb:hCG_2004608(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512385|imex:IM-12079-22 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000135093(gene)|ensembl:ENST00000257548(transcript)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000425"(pexophagy)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008053"(mitochondrial fusion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035871"(protein K11-linked deubiquitination)|go:"GO:0044313"(protein K6-linked deubiquitination)|go:"GO:0101005"(deubiquitinase activity)|go:"GO:1901525"(negative regulation of mitophagy)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|rcsb pdb:5OHK|rcsb pdb:5OHN|rcsb pdb:5OHP|reactome:R-HSA-5689880|reactome:R-HSA-9664873|refseq:NP_001288104.1|refseq:NP_116052.2|refseq:XP_006719716.1|dip:DIP-53578N ensembl:ENSG00000008382(gene)|ensembl:ENST00000599840(transcript)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0070122"(isopeptidase activity)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR037518|interpro:IPR040843|uniprotkb:A6NI36(uniprot-removed-ac)|refseq:NP_001287791.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:KWb+QBK14roR0XS+MQNdf60cO4w9606 rogid:wsvVZa3Y8NljS4QkxWoz4ACMpBc9606 intact-crc:E042755C6E22D33B|rigid:dHch+1JJsDENhffBRpKIjQHQKMU false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q70CQ3 uniprotkb:O75177 intact:EBI-2512374|ensembl:ENSP00000257548|uniprotkb:Q9BSS3|uniprotkb:Q96JX4|uniprotkb:Q8WTU7 intact:EBI-744674|uniprotkb:Q5JXJ3|uniprotkb:Q8NE69|uniprotkb:Q9BR55|uniprotkb:Q9H4K6|uniprotkb:A6NNE3|uniprotkb:A8K620|uniprotkb:B3KWR8|uniprotkb:Q6MZV9|uniprotkb:Q6NTH3|uniprotkb:Q6XYD9|uniprotkb:E1P5H7|ensembl:ENSP00000333012 psi-mi:ubp30_human(display_long)|uniprotkb:USP30(gene name)|psi-mi:USP30(display_short)|uniprotkb:Ubiquitin-specific-processing protease 30(gene name synonym)|uniprotkb:Deubiquitinating enzyme 30(gene name synonym)|uniprotkb:Ubiquitin thioesterase 30(gene name synonym) psi-mi:crest_human(display_long)|uniprotkb:SYT homolog 1(gene name synonym)|uniprotkb:KIAA0693(gene name synonym)|uniprotkb:SS18L1(gene name)|psi-mi:SS18L1(display_short)|uniprotkb:CREST(gene name synonym)|uniprotkb:SS18-like protein 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512385|imex:IM-12079-22 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000135093(gene)|ensembl:ENST00000257548(transcript)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000425"(pexophagy)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008053"(mitochondrial fusion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035871"(protein K11-linked deubiquitination)|go:"GO:0044313"(protein K6-linked deubiquitination)|go:"GO:0101005"(deubiquitinase activity)|go:"GO:1901525"(negative regulation of mitophagy)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|rcsb pdb:5OHK|rcsb pdb:5OHN|rcsb pdb:5OHP|reactome:R-HSA-5689880|reactome:R-HSA-9664873|refseq:NP_001288104.1|refseq:NP_116052.2|refseq:XP_006719716.1|dip:DIP-53578N refseq:NP_945173.1|refseq:XP_011527066.1|refseq:XP_011527069.1|ensembl:ENSG00000184402(gene)|ensembl:ENST00000331758(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0016358"(dendrite development)|go:"GO:0016604"(nuclear body)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050775"(positive regulation of dendrite morphogenesis)|go:"GO:0071565"(nBAF complex)|interpro:IPR007726(SSXT)|interpro:IPR044779|mint:O75177|refseq:NP_001288707.1|refseq:XP_005260448.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:KWb+QBK14roR0XS+MQNdf60cO4w9606 rogid:A7XGgvW0Roha0A4GgF5VvOC7dYs9606 intact-crc:E042755C6E22D33B|rigid:dHch+1JJsDENhffBRpKIjQHQKMU false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q70CQ3 uniprotkb:Q96PU8 intact:EBI-2512374|ensembl:ENSP00000257548|uniprotkb:Q9BSS3|uniprotkb:Q96JX4|uniprotkb:Q8WTU7 intact:EBI-945792|uniprotkb:Q2I375|uniprotkb:Q5MJQ1|uniprotkb:Q969L9|uniprotkb:Q96EJ3|uniprotkb:Q96KA3|uniprotkb:Q96PU6|uniprotkb:Q96PU7|uniprotkb:Q9P0X6|uniprotkb:Q9P0X7|uniprotkb:Q9P0X8|uniprotkb:Q9P0X9|uniprotkb:Q9P0Y0|uniprotkb:Q9P0Y1|ensembl:ENSP00000355094 psi-mi:ubp30_human(display_long)|uniprotkb:USP30(gene name)|psi-mi:USP30(display_short)|uniprotkb:Ubiquitin-specific-processing protease 30(gene name synonym)|uniprotkb:Deubiquitinating enzyme 30(gene name synonym)|uniprotkb:Ubiquitin thioesterase 30(gene name synonym) psi-mi:qki_human(display_long)|uniprotkb:QKI(gene name)|psi-mi:QKI(display_short)|uniprotkb:HKQ(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512385|imex:IM-12079-22 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000135093(gene)|ensembl:ENST00000257548(transcript)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000425"(pexophagy)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008053"(mitochondrial fusion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035871"(protein K11-linked deubiquitination)|go:"GO:0044313"(protein K6-linked deubiquitination)|go:"GO:0101005"(deubiquitinase activity)|go:"GO:1901525"(negative regulation of mitophagy)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|rcsb pdb:5OHK|rcsb pdb:5OHN|rcsb pdb:5OHP|reactome:R-HSA-5689880|reactome:R-HSA-9664873|refseq:NP_001288104.1|refseq:NP_116052.2|refseq:XP_006719716.1|dip:DIP-53578N refseq:NP_006766.1|refseq:NP_996735.1|refseq:NP_996736.1|refseq:NP_996737.1|refseq:NP_001288014.1|refseq:XP_011534561.1|ensembl:ENSG00000112531(gene)|ensembl:ENST00000361752(transcript)|go:"GO:0001570"(vasculogenesis)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006397"(mRNA processing)|go:"GO:0006417"(regulation of translation)|go:"GO:0007286"(spermatid development)|go:"GO:0008380"(RNA splicing)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0042552"(myelination)|go:"GO:0042692"(muscle cell differentiation)|go:"GO:0042759"(long-chain fatty acid biosynthetic process)|go:"GO:0045202"(synapse)|go:"GO:0048024"(regulation of mRNA splicing, via spliceosome)|go:"GO:0051028"(mRNA transport)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032367|interpro:IPR032377|interpro:IPR036612|mint:Q96PU8|rcsb pdb:4JVH|reactome:R-HSA-6802952 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:KWb+QBK14roR0XS+MQNdf60cO4w9606 rogid:7dcw5OyNAhQTE+yTch3qbSlZJdE9606 intact-crc:E042755C6E22D33B|rigid:dHch+1JJsDENhffBRpKIjQHQKMU false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q70CQ3 uniprotkb:O60220 intact:EBI-2512374|ensembl:ENSP00000257548|uniprotkb:Q9BSS3|uniprotkb:Q96JX4|uniprotkb:Q8WTU7 intact:EBI-1049822|uniprotkb:Q6IRW6|uniprotkb:B2R5A6|ensembl:ENSP00000361993 psi-mi:ubp30_human(display_long)|uniprotkb:USP30(gene name)|psi-mi:USP30(display_short)|uniprotkb:Ubiquitin-specific-processing protease 30(gene name synonym)|uniprotkb:Deubiquitinating enzyme 30(gene name synonym)|uniprotkb:Ubiquitin thioesterase 30(gene name synonym) psi-mi:tim8a_human(display_long)|uniprotkb:Deafness dystonia protein 1(gene name synonym)|uniprotkb:X-linked deafness dystonia protein(gene name synonym)|uniprotkb:TIMM8A(gene name)|psi-mi:TIMM8A(display_short)|uniprotkb:DDP(gene name synonym)|uniprotkb:DDP1(gene name synonym)|uniprotkb:TIM8A(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512385|imex:IM-12079-22 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000135093(gene)|ensembl:ENST00000257548(transcript)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000425"(pexophagy)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008053"(mitochondrial fusion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035871"(protein K11-linked deubiquitination)|go:"GO:0044313"(protein K6-linked deubiquitination)|go:"GO:0101005"(deubiquitinase activity)|go:"GO:1901525"(negative regulation of mitophagy)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|rcsb pdb:5OHK|rcsb pdb:5OHN|rcsb pdb:5OHP|reactome:R-HSA-5689880|reactome:R-HSA-9664873|refseq:NP_001288104.1|refseq:NP_116052.2|refseq:XP_006719716.1|dip:DIP-53578N refseq:NP_004076.1|reactome:R-HSA-1268020|ensembl:ENSG00000126953(gene)|ensembl:ENST00000372902(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0007399"(nervous system development)|go:"GO:0042802"(identical protein binding)|go:"GO:0045039"(protein insertion into mitochondrial inner membrane)|go:"GO:0046872"(metal ion binding)|interpro:IPR004217(Zinc finger, Tim10/DDP-type)|interpro:IPR035427|interpro:IPR039238|mint:O60220 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:KWb+QBK14roR0XS+MQNdf60cO4w9606 rogid:v01DxxXFU24eNjL3zVBvqQP9zA49606 intact-crc:E042755C6E22D33B|rigid:dHch+1JJsDENhffBRpKIjQHQKMU false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q70CQ3 uniprotkb:Q9H078 intact:EBI-2512374|ensembl:ENSP00000257548|uniprotkb:Q9BSS3|uniprotkb:Q96JX4|uniprotkb:Q8WTU7 intact:EBI-2107221|uniprotkb:Q8ND11|uniprotkb:Q9H8Y0|uniprotkb:B4DXW4|uniprotkb:B4DXJ7|uniprotkb:B4DXP7|uniprotkb:E7EWN6|uniprotkb:F8W7P6|ensembl:ENSP00000294053 psi-mi:ubp30_human(display_long)|uniprotkb:USP30(gene name)|psi-mi:USP30(display_short)|uniprotkb:Ubiquitin-specific-processing protease 30(gene name synonym)|uniprotkb:Deubiquitinating enzyme 30(gene name synonym)|uniprotkb:Ubiquitin thioesterase 30(gene name synonym) psi-mi:clpb_human(display_long)|uniprotkb:CLPB(gene name)|psi-mi:CLPB(display_short)|uniprotkb:HSP78(gene name synonym)|uniprotkb:SKD3(gene name synonym)|uniprotkb:Suppressor of potassium transport defect 3(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512385|imex:IM-12079-22 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000135093(gene)|ensembl:ENST00000257548(transcript)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000425"(pexophagy)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008053"(mitochondrial fusion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035871"(protein K11-linked deubiquitination)|go:"GO:0044313"(protein K6-linked deubiquitination)|go:"GO:0101005"(deubiquitinase activity)|go:"GO:1901525"(negative regulation of mitophagy)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|rcsb pdb:5OHK|rcsb pdb:5OHN|rcsb pdb:5OHP|reactome:R-HSA-5689880|reactome:R-HSA-9664873|refseq:NP_001288104.1|refseq:NP_116052.2|refseq:XP_006719716.1|dip:DIP-53578N refseq:NP_110440.1|refseq:NP_001245321.1|refseq:NP_001245322.1|refseq:NP_001245323.1|ensembl:ENSG00000162129(gene)|ensembl:ENST00000294053(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0034605"(cellular response to heat)|go:"GO:0039529"(RIG-I signaling pathway)|go:"GO:0140374"(antiviral innate immune response)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001270(Chaperonin clpA/B)|interpro:IPR002110(Ankyrin)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR019489|interpro:IPR020683|interpro:IPR027417|interpro:IPR036770|mint:Q9H078 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:KWb+QBK14roR0XS+MQNdf60cO4w9606 rogid:QqIOYOITwDC+c8kKtMGBHa/0Tjk9606 intact-crc:E042755C6E22D33B|rigid:dHch+1JJsDENhffBRpKIjQHQKMU false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9P275 uniprotkb:Q8NB46 intact:EBI-2512419|ensembl:ENSP00000310590|ensembl:ENSP00000441214|ensembl:ENSP00000467280|uniprotkb:Q8NDM8|uniprotkb:Q05DD0|uniprotkb:Q9NVC8|uniprotkb:Q05C98|uniprotkb:Q6IQ38 intact:EBI-1996119|uniprotkb:B1Q2K2|uniprotkb:A6NE79|ensembl:ENSP00000267116 psi-mi:ubp36_human(display_long)|uniprotkb:USP36(gene name)|psi-mi:USP36(display_short)|uniprotkb:KIAA1453(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 36(gene name synonym)|uniprotkb:Deubiquitinating enzyme 36(gene name synonym)|uniprotkb:Ubiquitin thioesterase 36(gene name synonym) psi-mi:anr52_human(display_long)|uniprotkb:ANKRD52(gene name)|psi-mi:ANKRD52(display_short)|uniprotkb:Ankyrin repeat domain-containing protein 52(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512446|imex:IM-12079-73 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000055483(gene)|ensembl:ENST00000312010(transcript)|ensembl:ENST00000542802(transcript)|ensembl:ENST00000589225(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007000"(nucleolus organization)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0016578"(histone deubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0016607"(nuclear speck)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0050821"(protein stabilization)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:2000232"(regulation of rRNA processing)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|refseq:XP_005257599.1|refseq:XP_005257600.1|refseq:XP_016880389.1|refseq:NP_001308220.1 refseq:NP_775866.2|ensembl:ENSG00000139645(gene)|ensembl:ENST00000267116(transcript)|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR036770 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:91IyxhRDumStuUMNS8qNaB8SUMA9606 rogid:yDxfgyMLVZlGwQW0OSokGlMkmPo9606 intact-crc:32BD0EF074697E39|rigid:oMf3U5csDW3cQ3wR12IV6rc5UME false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9P275 uniprotkb:Q9UJV9 intact:EBI-2512419|ensembl:ENSP00000310590|ensembl:ENSP00000441214|ensembl:ENSP00000467280|uniprotkb:Q8NDM8|uniprotkb:Q05DD0|uniprotkb:Q9NVC8|uniprotkb:Q05C98|uniprotkb:Q6IQ38 intact:EBI-1046350|ensembl:ENSP00000330349|uniprotkb:Q96BK6|uniprotkb:Q96K05|uniprotkb:Q9NT96|uniprotkb:Q9NW04|uniprotkb:B2RDC8 psi-mi:ubp36_human(display_long)|uniprotkb:USP36(gene name)|psi-mi:USP36(display_short)|uniprotkb:KIAA1453(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 36(gene name synonym)|uniprotkb:Deubiquitinating enzyme 36(gene name synonym)|uniprotkb:Ubiquitin thioesterase 36(gene name synonym) psi-mi:ddx41_human(display_long)|uniprotkb:DEAD box protein 41(gene name synonym)|uniprotkb:DEAD box protein abstrakt homolog(gene name synonym)|uniprotkb:DDX41(gene name)|psi-mi:DDX41(display_short)|uniprotkb:ABS(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512446|imex:IM-12079-73 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000055483(gene)|ensembl:ENST00000312010(transcript)|ensembl:ENST00000542802(transcript)|ensembl:ENST00000589225(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007000"(nucleolus organization)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0016578"(histone deubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0016607"(nuclear speck)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0050821"(protein stabilization)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:2000232"(regulation of rRNA processing)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|refseq:XP_005257599.1|refseq:XP_005257600.1|refseq:XP_016880389.1|refseq:NP_001308220.1 ensembl:ENSG00000183258(gene)|ensembl:ENST00000330503(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0030154"(cell differentiation)|go:"GO:0046872"(metal ion binding)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|interpro:IPR044113|mint:Q9UJV9|rcsb pdb:2P6N|rcsb pdb:5GVS|rcsb pdb:5H1Y|reactome:R-HSA-1834941|reactome:R-HSA-3134975|reactome:R-HSA-3270619|rcsb pdb:5GVR|refseq:NP_057306.2|refseq:NP_001308661.1|refseq:NP_001308759.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:91IyxhRDumStuUMNS8qNaB8SUMA9606 rogid:a3HNDsQBaXs/1q8ZXjkcMgEhPes9606 intact-crc:32BD0EF074697E39|rigid:oMf3U5csDW3cQ3wR12IV6rc5UME false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9P275 uniprotkb:Q14839 intact:EBI-2512419|ensembl:ENSP00000310590|ensembl:ENSP00000441214|ensembl:ENSP00000467280|uniprotkb:Q8NDM8|uniprotkb:Q05DD0|uniprotkb:Q9NVC8|uniprotkb:Q05C98|uniprotkb:Q6IQ38 intact:EBI-372916|uniprotkb:Q8IXZ5|intact:EBI-28978241|ensembl:ENSP00000440542 psi-mi:ubp36_human(display_long)|uniprotkb:USP36(gene name)|psi-mi:USP36(display_short)|uniprotkb:KIAA1453(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 36(gene name synonym)|uniprotkb:Deubiquitinating enzyme 36(gene name synonym)|uniprotkb:Ubiquitin thioesterase 36(gene name synonym) psi-mi:chd4_human(display_long)|uniprotkb:CHD4(gene name)|psi-mi:CHD4(display_short)|uniprotkb:ATP-dependent helicase CHD4(gene name synonym)|uniprotkb:Mi-2 autoantigen 218 kDa protein(gene name synonym)|uniprotkb:Mi2-beta(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512446|imex:IM-12079-73 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000055483(gene)|ensembl:ENST00000312010(transcript)|ensembl:ENST00000542802(transcript)|ensembl:ENST00000589225(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007000"(nucleolus organization)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0016578"(histone deubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0016607"(nuclear speck)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0050821"(protein stabilization)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:2000232"(regulation of rRNA processing)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|refseq:XP_005257599.1|refseq:XP_005257600.1|refseq:XP_016880389.1|refseq:NP_001308220.1 ensembl:ENSP00000440542|ensembl:ENST00000645095|ensembl:ENSP00000496634|refseq:NP_001264.2|refseq:XP_006719021.1|refseq:NP_001284482.1|ensembl:ENSG00000111642(gene)|ensembl:ENST00000544040(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016020"(membrane)|go:"GO:0016581"(NuRD complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043044"|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070615"|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR000330(SNF2-related)|interpro:IPR000953(Chromo domain)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR002464(DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site)|interpro:IPR009462(Protein of unknown function DUF1086)|interpro:IPR009463(Protein of unknown function DUF1087)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR012957(CHD, C-terminal 2)|interpro:IPR012958(CHD, N-terminal)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR016197(Chromo domain-like)|interpro:IPR019786|interpro:IPR019787|interpro:IPR023780|interpro:IPR027417|interpro:IPR038718|mint:Q14839|rcsb pdb:1MM2|rcsb pdb:1MM3|rcsb pdb:2EE1|rcsb pdb:2L5U|rcsb pdb:2L75|rcsb pdb:2N5N|rcsb pdb:4O9I|rcsb pdb:6BGG|rcsb pdb:6Q3M|rcsb pdb:6RYR|rcsb pdb:6RYU|reactome:R-HSA-3214815|reactome:R-HSA-427389|reactome:R-HSA-6804758|reactome:R-HSA-73762|reactome:R-HSA-8943724|reactome:R-HSA-9031628|reactome:R-HSA-9679191|dip:DIP-31183N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:91IyxhRDumStuUMNS8qNaB8SUMA9606 rogid:E9eHT/41SIFRiz54J81hvPQeHIE9606 intact-crc:32BD0EF074697E39|rigid:oMf3U5csDW3cQ3wR12IV6rc5UME false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9P275 uniprotkb:Q15269 intact:EBI-2512419|ensembl:ENSP00000310590|ensembl:ENSP00000441214|ensembl:ENSP00000467280|uniprotkb:Q8NDM8|uniprotkb:Q05DD0|uniprotkb:Q9NVC8|uniprotkb:Q05C98|uniprotkb:Q6IQ38 intact:EBI-722224|uniprotkb:Q96A77|uniprotkb:B2RAG8|ensembl:ENSP00000291576 psi-mi:ubp36_human(display_long)|uniprotkb:USP36(gene name)|psi-mi:USP36(display_short)|uniprotkb:KIAA1453(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 36(gene name synonym)|uniprotkb:Deubiquitinating enzyme 36(gene name synonym)|uniprotkb:Ubiquitin thioesterase 36(gene name synonym) psi-mi:pwp2_human(display_long)|uniprotkb:PWP2(gene name)|psi-mi:PWP2(display_short)|uniprotkb:PWP2H(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512446|imex:IM-12079-73 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000055483(gene)|ensembl:ENST00000312010(transcript)|ensembl:ENST00000542802(transcript)|ensembl:ENST00000589225(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007000"(nucleolus organization)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0016578"(histone deubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0016607"(nuclear speck)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0050821"(protein stabilization)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:2000232"(regulation of rRNA processing)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|refseq:XP_005257599.1|refseq:XP_005257600.1|refseq:XP_016880389.1|refseq:NP_001308220.1 refseq:NP_005040.2|refseq:XP_006723973.1|refseq:XP_011507205.1|ensembl:ENSG00000241945(gene)|ensembl:ENST00000291576(transcript)|go:"GO:0000028"(ribosomal small subunit assembly)|go:"GO:0000462"("maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0032040"(small-subunit processome)|go:"GO:0034388"(Pwp2p-containing subcomplex of 90S preribosome)|interpro:IPR001680(WD40 repeat)|interpro:IPR007148(Small-subunit processome, Utp12)|interpro:IPR011047(Quinonprotein alcohol dehydrogenase-like)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR027145|reactome:R-HSA-6790901|reactome:R-HSA-6791226 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:91IyxhRDumStuUMNS8qNaB8SUMA9606 rogid:PYs2LKd3EMjAnp0engZvZn0CeBo9606 intact-crc:32BD0EF074697E39|rigid:oMf3U5csDW3cQ3wR12IV6rc5UME false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9P275 uniprotkb:Q9UNX4 intact:EBI-2512419|ensembl:ENSP00000310590|ensembl:ENSP00000441214|ensembl:ENSP00000467280|uniprotkb:Q8NDM8|uniprotkb:Q05DD0|uniprotkb:Q9NVC8|uniprotkb:Q05C98|uniprotkb:Q6IQ38 intact:EBI-727436|ensembl:ENSP00000308179 psi-mi:ubp36_human(display_long)|uniprotkb:USP36(gene name)|psi-mi:USP36(display_short)|uniprotkb:KIAA1453(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 36(gene name synonym)|uniprotkb:Deubiquitinating enzyme 36(gene name synonym)|uniprotkb:Ubiquitin thioesterase 36(gene name synonym) psi-mi:wdr3_human(display_long)|uniprotkb:WDR3(gene name)|psi-mi:WDR3(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512446|imex:IM-12079-73 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000055483(gene)|ensembl:ENST00000312010(transcript)|ensembl:ENST00000542802(transcript)|ensembl:ENST00000589225(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007000"(nucleolus organization)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0016578"(histone deubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0016607"(nuclear speck)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0050821"(protein stabilization)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:2000232"(regulation of rRNA processing)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|refseq:XP_005257599.1|refseq:XP_005257600.1|refseq:XP_016880389.1|refseq:NP_001308220.1 refseq:NP_006775.1|ensembl:ENSG00000065183(gene)|ensembl:ENST00000349139(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0030490"(maturation of SSU-rRNA)|go:"GO:0030515"(snoRNA binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032040"(small-subunit processome)|go:"GO:0034388"(Pwp2p-containing subcomplex of 90S preribosome)|interpro:IPR001680(WD40 repeat)|interpro:IPR007148(Small-subunit processome, Utp12)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR024977|interpro:IPR036322|mint:Q9UNX4|reactome:R-HSA-6790901|reactome:R-HSA-6791226 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:91IyxhRDumStuUMNS8qNaB8SUMA9606 rogid:aslkTiEP+9ytaN6cc+SC+TzOxUg9606 intact-crc:32BD0EF074697E39|rigid:oMf3U5csDW3cQ3wR12IV6rc5UME false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9P275 uniprotkb:Q9BW27 intact:EBI-2512419|ensembl:ENSP00000310590|ensembl:ENSP00000441214|ensembl:ENSP00000467280|uniprotkb:Q8NDM8|uniprotkb:Q05DD0|uniprotkb:Q9NVC8|uniprotkb:Q05C98|uniprotkb:Q6IQ38 intact:EBI-716392|intact:EBI-2563151|uniprotkb:Q9H9U1|uniprotkb:Q8NDI4|uniprotkb:B4DMQ3|uniprotkb:B4DPW1|ensembl:ENSP00000245544 psi-mi:ubp36_human(display_long)|uniprotkb:USP36(gene name)|psi-mi:USP36(display_short)|uniprotkb:KIAA1453(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 36(gene name synonym)|uniprotkb:Deubiquitinating enzyme 36(gene name synonym)|uniprotkb:Ubiquitin thioesterase 36(gene name synonym) psi-mi:nup85_human(display_long)|uniprotkb:PCNT1(gene name synonym)|uniprotkb:Nucleoporin Nup85(gene name synonym)|uniprotkb:85 kDa nucleoporin(gene name synonym)|uniprotkb:Nucleoporin Nup75(gene name synonym)|uniprotkb:Pericentrin-1(gene name synonym)|uniprotkb:FROUNT(gene name synonym)|uniprotkb:NUP85(gene name)|psi-mi:NUP85(display_short)|uniprotkb:NUP75(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512446|imex:IM-12079-73 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000055483(gene)|ensembl:ENST00000312010(transcript)|ensembl:ENST00000542802(transcript)|ensembl:ENST00000589225(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007000"(nucleolus organization)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0016578"(histone deubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0016607"(nuclear speck)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0050821"(protein stabilization)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:2000232"(regulation of rRNA processing)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|refseq:XP_005257599.1|refseq:XP_005257600.1|refseq:XP_016880389.1|refseq:NP_001308220.1 refseq:NP_079120.1|refseq:NP_001290205.1|ensembl:ENSG00000125450(gene)|ensembl:ENST00000245544(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0006406"(mRNA export from nucleus)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0016020"(membrane)|go:"GO:0017056"(structural constituent of nuclear pore)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0031080"(nuclear pore outer ring)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048246"(macrophage chemotaxis)|go:"GO:0072006"(nephron development)|interpro:IPR011502(Nucleoporin, Nup85-like)|mint:Q9BW27|rcsb pdb:5A9Q|reactome:R-HSA-1169408|reactome:R-HSA-141444|reactome:R-HSA-159227|reactome:R-HSA-159230|reactome:R-HSA-159231|reactome:R-HSA-159236|reactome:R-HSA-165054|reactome:R-HSA-168271|reactome:R-HSA-168276|reactome:R-HSA-168325|reactome:R-HSA-168333|reactome:R-HSA-170822|reactome:R-HSA-180746|reactome:R-HSA-180910|reactome:R-HSA-191859|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-3108214|reactome:R-HSA-3232142|reactome:R-HSA-3301854|reactome:R-HSA-3371453|reactome:R-HSA-4085377|reactome:R-HSA-4551638|reactome:R-HSA-4570464|reactome:R-HSA-4615885|reactome:R-HSA-5578749|reactome:R-HSA-5619107|reactome:R-HSA-5663220|reactome:R-HSA-6784531|reactome:R-HSA-68877|reactome:R-HSA-9609690|reactome:R-HSA-9610379|reactome:R-HSA-9615933|reactome:R-HSA-9648025 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:91IyxhRDumStuUMNS8qNaB8SUMA9606 rogid:MWeo3e2aXVKhP1gFV8ZZrgyFSeI9606 intact-crc:32BD0EF074697E39|rigid:oMf3U5csDW3cQ3wR12IV6rc5UME false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9P275 uniprotkb:Q149N8 intact:EBI-2512419|ensembl:ENSP00000310590|ensembl:ENSP00000441214|ensembl:ENSP00000467280|uniprotkb:Q8NDM8|uniprotkb:Q05DD0|uniprotkb:Q9NVC8|uniprotkb:Q05C98|uniprotkb:Q6IQ38 intact:EBI-714105|uniprotkb:Q149N9|uniprotkb:Q5VV79|uniprotkb:Q68DS5|uniprotkb:Q7Z5J5|uniprotkb:Q8IVE8|uniprotkb:Q8IWQ9|uniprotkb:Q8N1S8|uniprotkb:Q8NBR7|ensembl:ENSP00000275233|ensembl:ENSP00000356475 psi-mi:ubp36_human(display_long)|uniprotkb:USP36(gene name)|psi-mi:USP36(display_short)|uniprotkb:KIAA1453(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 36(gene name synonym)|uniprotkb:Deubiquitinating enzyme 36(gene name synonym)|uniprotkb:Ubiquitin thioesterase 36(gene name synonym) psi-mi:shprh_human(display_long)|uniprotkb:SNF2, histone-linker, PHD and RING finger domain-containing helicase(gene name synonym)|uniprotkb:SHPRH(gene name)|psi-mi:SHPRH(display_short)|uniprotkb:KIAA2023(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase SHPRH(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512446|imex:IM-12079-73 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000055483(gene)|ensembl:ENST00000312010(transcript)|ensembl:ENST00000542802(transcript)|ensembl:ENST00000589225(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007000"(nucleolus organization)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0016578"(histone deubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0016607"(nuclear speck)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0050821"(protein stabilization)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:2000232"(regulation of rRNA processing)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|refseq:XP_005257599.1|refseq:XP_005257600.1|refseq:XP_016880389.1|refseq:NP_001308220.1 refseq:XP_006715504.1|ensembl:ENSG00000146414(gene)|ensembl:ENST00000275233(transcript)|ensembl:ENST00000367505(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0004386"(helicase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016787"(hydrolase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070615"|interpro:IPR000330(SNF2-related)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR001965(Zinc finger, PHD-type)|go:"GO:0031625"(ubiquitin protein ligase binding)|interpro:IPR005818(Histone H1/H5)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR017907|interpro:IPR019786|interpro:IPR027417|interpro:IPR036388|interpro:IPR036390|interpro:IPR038718|mint:Q149N8|rcsb pdb:2M85|rcsb pdb:4QN1|reactome:R-HSA-8866654|refseq:NP_001036148.2|refseq:NP_775105.1|dip:DIP-46277N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:91IyxhRDumStuUMNS8qNaB8SUMA9606 rogid:WqU1cBAHV1M5PmgDpqRh11/rNmA9606 intact-crc:32BD0EF074697E39|rigid:oMf3U5csDW3cQ3wR12IV6rc5UME false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9P275 uniprotkb:Q6ZN17 intact:EBI-2512419|ensembl:ENSP00000310590|ensembl:ENSP00000441214|ensembl:ENSP00000467280|uniprotkb:Q8NDM8|uniprotkb:Q05DD0|uniprotkb:Q9NVC8|uniprotkb:Q05C98|uniprotkb:Q6IQ38 intact:EBI-2462592|uniprotkb:B2RPN6|uniprotkb:A1L165|uniprotkb:Q5TCM4|ensembl:ENSP00000344401 psi-mi:ubp36_human(display_long)|uniprotkb:USP36(gene name)|psi-mi:USP36(display_short)|uniprotkb:KIAA1453(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 36(gene name synonym)|uniprotkb:Deubiquitinating enzyme 36(gene name synonym)|uniprotkb:Ubiquitin thioesterase 36(gene name synonym) psi-mi:ln28b_human(display_long)|uniprotkb:LIN28B(gene name)|psi-mi:LIN28B(display_short)|uniprotkb:CSDD2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512446|imex:IM-12079-73 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000055483(gene)|ensembl:ENST00000312010(transcript)|ensembl:ENST00000542802(transcript)|ensembl:ENST00000589225(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007000"(nucleolus organization)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0016578"(histone deubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0016607"(nuclear speck)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0050821"(protein stabilization)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:2000232"(regulation of rRNA processing)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|refseq:XP_005257599.1|refseq:XP_005257600.1|refseq:XP_016880389.1|refseq:NP_001308220.1 refseq:NP_001004317.1|ensembl:ENSG00000187772(gene)|ensembl:ENST00000345080(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010587"(miRNA catabolic process)|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0031123"(RNA 3'-end processing)|go:"GO:0050779"(RNA destabilization)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000627"(positive regulation of miRNA catabolic process)|go:"GO:2000632"(negative regulation of pre-miRNA processing)|go:"GO:2000635"(negative regulation of primary miRNA processing)|interpro:IPR001878(Zinc finger, CCHC-type)|interpro:IPR002059(Cold-shock protein, DNA-binding)|interpro:IPR011129(Cold shock protein)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR036875|rcsb pdb:4A4I psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:91IyxhRDumStuUMNS8qNaB8SUMA9606 rogid:fsajK9bTHAkQUEfwVbobY9jrS9M9606 intact-crc:32BD0EF074697E39|rigid:oMf3U5csDW3cQ3wR12IV6rc5UME false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9P275 uniprotkb:Q9Y5J1 intact:EBI-2512419|ensembl:ENSP00000310590|ensembl:ENSP00000441214|ensembl:ENSP00000467280|uniprotkb:Q8NDM8|uniprotkb:Q05DD0|uniprotkb:Q9NVC8|uniprotkb:Q05C98|uniprotkb:Q6IQ38 intact:EBI-592816|uniprotkb:Q9H4N6|ensembl:ENSP00000225298 psi-mi:ubp36_human(display_long)|uniprotkb:USP36(gene name)|psi-mi:USP36(display_short)|uniprotkb:KIAA1453(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 36(gene name synonym)|uniprotkb:Deubiquitinating enzyme 36(gene name synonym)|uniprotkb:Ubiquitin thioesterase 36(gene name synonym) psi-mi:utp18_human(display_long)|uniprotkb:WD repeat-containing protein 50(gene name synonym)|uniprotkb:UTP18(gene name)|psi-mi:UTP18(display_short)|uniprotkb:CGI-48(orf name)|uniprotkb:CDABP0061(orf name)|uniprotkb:WDR50(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512446|imex:IM-12079-73 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000055483(gene)|ensembl:ENST00000312010(transcript)|ensembl:ENST00000542802(transcript)|ensembl:ENST00000589225(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007000"(nucleolus organization)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0016578"(histone deubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0016607"(nuclear speck)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0050821"(protein stabilization)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:2000232"(regulation of rRNA processing)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|refseq:XP_005257599.1|refseq:XP_005257600.1|refseq:XP_016880389.1|refseq:NP_001308220.1 refseq:NP_057085.2|ensembl:ENSG00000011260(gene)|ensembl:ENST00000225298(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006364"(rRNA processing)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032040"(small-subunit processome)|go:"GO:0034388"(Pwp2p-containing subcomplex of 90S preribosome)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|mint:Q9Y5J1|reactome:R-HSA-6790901|reactome:R-HSA-6791226 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:91IyxhRDumStuUMNS8qNaB8SUMA9606 rogid:l873IUyfCql4N9VelHPuUEqpzRY9606 intact-crc:32BD0EF074697E39|rigid:oMf3U5csDW3cQ3wR12IV6rc5UME false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9P275 uniprotkb:Q13823 intact:EBI-2512419|ensembl:ENSP00000310590|ensembl:ENSP00000441214|ensembl:ENSP00000467280|uniprotkb:Q8NDM8|uniprotkb:Q05DD0|uniprotkb:Q9NVC8|uniprotkb:Q05C98|uniprotkb:Q6IQ38 intact:EBI-1043365|uniprotkb:Q9BWN7|ensembl:ENSP00000362153 psi-mi:ubp36_human(display_long)|uniprotkb:USP36(gene name)|psi-mi:USP36(display_short)|uniprotkb:KIAA1453(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 36(gene name synonym)|uniprotkb:Deubiquitinating enzyme 36(gene name synonym)|uniprotkb:Ubiquitin thioesterase 36(gene name synonym) psi-mi:nog2_human(display_long)|uniprotkb:Autoantigen NGP-1(gene name synonym)|uniprotkb:GNL2(gene name)|psi-mi:GNL2(display_short)|uniprotkb:NGP1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512446|imex:IM-12079-73 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000055483(gene)|ensembl:ENST00000312010(transcript)|ensembl:ENST00000542802(transcript)|ensembl:ENST00000589225(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007000"(nucleolus organization)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0016578"(histone deubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0016607"(nuclear speck)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0050821"(protein stabilization)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:2000232"(regulation of rRNA processing)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|refseq:XP_005257599.1|refseq:XP_005257600.1|refseq:XP_016880389.1|refseq:NP_001308220.1 ensembl:ENSG00000134697(gene)|ensembl:ENST00000373062(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0016020"(membrane)|go:"GO:0042254"(ribosome biogenesis)|interpro:IPR006073(GTP1/OBG)|interpro:IPR012971(NGP1, N-terminal)|interpro:IPR023179|interpro:IPR024929|interpro:IPR027417|interpro:IPR030378|mint:Q13823|rcsb pdb:6LSS|rcsb pdb:6LU8|refseq:NP_037417.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:91IyxhRDumStuUMNS8qNaB8SUMA9606 rogid:CgIg/QNhk71SHIhV4iLvIuC/HUo9606 intact-crc:32BD0EF074697E39|rigid:oMf3U5csDW3cQ3wR12IV6rc5UME false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9P275 uniprotkb:O15355 intact:EBI-2512419|ensembl:ENSP00000310590|ensembl:ENSP00000441214|ensembl:ENSP00000467280|uniprotkb:Q8NDM8|uniprotkb:Q05DD0|uniprotkb:Q9NVC8|uniprotkb:Q05C98|uniprotkb:Q6IQ38 intact:EBI-725702|ensembl:ENSP00000342778 psi-mi:ubp36_human(display_long)|uniprotkb:USP36(gene name)|psi-mi:USP36(display_short)|uniprotkb:KIAA1453(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 36(gene name synonym)|uniprotkb:Deubiquitinating enzyme 36(gene name synonym)|uniprotkb:Ubiquitin thioesterase 36(gene name synonym) psi-mi:ppm1g_human(display_long)|uniprotkb:Protein phosphatase 2C isoform gamma(gene name synonym)|uniprotkb:Protein phosphatase magnesium-dependent 1 gamma(gene name synonym)|uniprotkb:Protein phosphatase 1C(gene name synonym)|uniprotkb:PPM1G(gene name)|psi-mi:PPM1G(display_short)|uniprotkb:PPM1C(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512446|imex:IM-12079-73 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000055483(gene)|ensembl:ENST00000312010(transcript)|ensembl:ENST00000542802(transcript)|ensembl:ENST00000589225(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007000"(nucleolus organization)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0016578"(histone deubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0016607"(nuclear speck)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0050821"(protein stabilization)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:2000232"(regulation of rRNA processing)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|refseq:XP_005257599.1|refseq:XP_005257600.1|refseq:XP_016880389.1|refseq:NP_001308220.1 refseq:NP_817092.1|ensembl:ENST00000344034(transcript)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006470"(protein dephosphorylation)|ensembl:ENSG00000115241(gene)|go:"GO:0016020"(membrane)|go:"GO:0035970"(peptidyl-threonine dephosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0106306"|go:"GO:0106307"|interpro:IPR000222(Protein phosphatase 2C, manganese/magnesium aspartate binding site)|interpro:IPR001932(Protein phosphatase 2C-related)|interpro:IPR015655(Protein phosphatase 2C)|interpro:IPR036457|mint:O15355|dip:DIP-29404N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:91IyxhRDumStuUMNS8qNaB8SUMA9606 rogid:j9ut2f7QHVyOtsLuYJ8e2XOP3HE9606 intact-crc:32BD0EF074697E39|rigid:oMf3U5csDW3cQ3wR12IV6rc5UME false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9P275 uniprotkb:Q9NVI1 intact:EBI-2512419|ensembl:ENSP00000310590|ensembl:ENSP00000441214|ensembl:ENSP00000467280|uniprotkb:Q8NDM8|uniprotkb:Q05DD0|uniprotkb:Q9NVC8|uniprotkb:Q05C98|uniprotkb:Q6IQ38 intact:EBI-1013291|uniprotkb:Q96JN1|uniprotkb:Q96ST0|uniprotkb:Q9BT96|uniprotkb:A5YMH4|uniprotkb:A6NJZ0|uniprotkb:A4ZVE4|ensembl:ENSP00000310842 psi-mi:ubp36_human(display_long)|uniprotkb:USP36(gene name)|psi-mi:USP36(display_short)|uniprotkb:KIAA1453(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 36(gene name synonym)|uniprotkb:Deubiquitinating enzyme 36(gene name synonym)|uniprotkb:Ubiquitin thioesterase 36(gene name synonym) psi-mi:fanci_human(display_long)|uniprotkb:FANCI(gene name)|psi-mi:FANCI(display_short)|uniprotkb:KIAA1794(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512446|imex:IM-12079-73 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000055483(gene)|ensembl:ENST00000312010(transcript)|ensembl:ENST00000542802(transcript)|ensembl:ENST00000589225(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007000"(nucleolus organization)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0016578"(histone deubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0016607"(nuclear speck)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0050821"(protein stabilization)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:2000232"(regulation of rRNA processing)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|refseq:XP_005257599.1|refseq:XP_005257600.1|refseq:XP_016880389.1|refseq:NP_001308220.1 refseq:XP_011520058.1|refseq:XP_011520059.1|refseq:XP_011520066.1|refseq:NP_001106849.1|refseq:NP_060663.2|dip:DIP-29381N|ensembl:ENSG00000140525(gene)|ensembl:ENST00000310775(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0007049"(cell cycle)|go:"GO:0016020"(membrane)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0070182"(DNA polymerase binding)|interpro:IPR026171|interpro:IPR029305|interpro:IPR029308|interpro:IPR029310|interpro:IPR029312|interpro:IPR029313|interpro:IPR029314|interpro:IPR029315|mint:Q9NVI1|rcsb pdb:6VAA|rcsb pdb:6VAD|rcsb pdb:6VAE|rcsb pdb:6VAF|rcsb pdb:7AY1|reactome:R-HSA-6783310|reactome:R-HSA-6796648 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:91IyxhRDumStuUMNS8qNaB8SUMA9606 rogid:yJJMHIBOVPDIQcCBJ19DGitg3VA9606 intact-crc:32BD0EF074697E39|rigid:oMf3U5csDW3cQ3wR12IV6rc5UME false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9P275 uniprotkb:Q96RS6 intact:EBI-2512419|ensembl:ENSP00000310590|ensembl:ENSP00000441214|ensembl:ENSP00000467280|uniprotkb:Q8NDM8|uniprotkb:Q05DD0|uniprotkb:Q9NVC8|uniprotkb:Q05C98|uniprotkb:Q6IQ38 intact:EBI-2512429|ensembl:ENSP00000239690|uniprotkb:Q96SI4|uniprotkb:B4DVX6|uniprotkb:Q8NG18|uniprotkb:Q4G130|uniprotkb:Q8NDQ5|uniprotkb:Q9BVR5 psi-mi:ubp36_human(display_long)|uniprotkb:USP36(gene name)|psi-mi:USP36(display_short)|uniprotkb:KIAA1453(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 36(gene name synonym)|uniprotkb:Deubiquitinating enzyme 36(gene name synonym)|uniprotkb:Ubiquitin thioesterase 36(gene name synonym) psi-mi:nudc1_human(display_long)|uniprotkb:NUDCD1(gene name)|psi-mi:NUDCD1(display_short)|uniprotkb:CML66(gene name synonym)|uniprotkb:Chronic myelogenous leukemia tumor antigen 66(gene name synonym)|uniprotkb:Tumor antigen CML66(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512446|imex:IM-12079-73 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000055483(gene)|ensembl:ENST00000312010(transcript)|ensembl:ENST00000542802(transcript)|ensembl:ENST00000589225(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007000"(nucleolus organization)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0016578"(histone deubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0016607"(nuclear speck)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0050821"(protein stabilization)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:2000232"(regulation of rRNA processing)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|refseq:XP_005257599.1|refseq:XP_005257600.1|refseq:XP_016880389.1|refseq:NP_001308220.1 ensembl:ENSG00000120526(gene)|ensembl:ENST00000239690(transcript)|go:"GO:0002376"(immune system process)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR037895|refseq:NP_001121683.1|refseq:NP_116258.2|refseq:XP_016869399.1|refseq:XP_016869400.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:91IyxhRDumStuUMNS8qNaB8SUMA9606 rogid:VfINO8Qk3jMFWzVI+0Bd6xk90/E9606 intact-crc:32BD0EF074697E39|rigid:oMf3U5csDW3cQ3wR12IV6rc5UME false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9P275 uniprotkb:P09874 intact:EBI-2512419|ensembl:ENSP00000310590|ensembl:ENSP00000441214|ensembl:ENSP00000467280|uniprotkb:Q8NDM8|uniprotkb:Q05DD0|uniprotkb:Q9NVC8|uniprotkb:Q05C98|uniprotkb:Q6IQ38 intact:EBI-355676|uniprotkb:Q8IUZ9|uniprotkb:B1ANJ4|ensembl:ENSP00000355759 psi-mi:ubp36_human(display_long)|uniprotkb:USP36(gene name)|psi-mi:USP36(display_short)|uniprotkb:KIAA1453(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 36(gene name synonym)|uniprotkb:Deubiquitinating enzyme 36(gene name synonym)|uniprotkb:Ubiquitin thioesterase 36(gene name synonym) psi-mi:parp1_human(display_long)|uniprotkb:PARP1(gene name)|psi-mi:PARP1(display_short)|uniprotkb:ADPRT(gene name synonym)|uniprotkb:PPOL(gene name synonym)|uniprotkb:"NAD(+) ADP-ribosyltransferase 1"(gene name synonym)|uniprotkb:Poly[ADP-ribose] synthase 1(gene name synonym)|uniprotkb:ADP-ribosyltransferase diphtheria toxin-like 1(gene name synonym)|uniprotkb:DNA ADP-ribosyltransferase PARP1(gene name synonym)|uniprotkb:Protein poly-ADP-ribosyltransferase PARP1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512446|imex:IM-12079-73 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000055483(gene)|ensembl:ENST00000312010(transcript)|ensembl:ENST00000542802(transcript)|ensembl:ENST00000589225(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007000"(nucleolus organization)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0016578"(histone deubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0016607"(nuclear speck)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0050821"(protein stabilization)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:2000232"(regulation of rRNA processing)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|refseq:XP_005257599.1|refseq:XP_005257600.1|refseq:XP_016880389.1|refseq:NP_001308220.1 refseq:NP_001609.2|rcsb pdb:7AAC|rcsb pdb:7AAD|rcsb pdb:6NRJ|rcsb pdb:6NTU|rcsb pdb:7CMW|rcsb pdb:6VKK|rcsb pdb:7KK2|rcsb pdb:7KK3|rcsb pdb:7KK4|rcsb pdb:7KK5|rcsb pdb:7KK6|reactome:R-HSA-110362|reactome:R-HSA-192814|reactome:R-HSA-2173795|reactome:R-HSA-3108214|reactome:R-HSA-5685939|reactome:R-HSA-5696394|reactome:R-HSA-5696395|reactome:R-HSA-5696400|rcsb pdb:6VKO|rcsb pdb:6VKQ|rcsb pdb:6XVW|rcsb pdb:7AAA|rcsb pdb:7AAB|ensembl:ENSG00000143799(gene)|ensembl:ENST00000366794(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005739"(mitochondrion)|go:"GO:0006281"(DNA repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0010990"(regulation of SMAD protein complex assembly)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0016604"(nuclear body)|go:"GO:0018312"(peptidyl-serine ADP-ribosylation)|go:"GO:0018424"(peptidyl-glutamic acid poly-ADP-ribosylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030592"(DNA ADP-ribosylation)|go:"GO:0032042"(mitochondrial DNA metabolic process)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0008270"(zinc ion binding)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036211"(protein modification process)|go:"GO:0042769"(obsolete DNA damage response, detection of DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043504"(mitochondrial DNA repair)|go:"GO:0044030"(regulation of DNA methylation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051287"(NAD binding)|go:"GO:0051901"(positive regulation of mitochondrial depolarization)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0070212"(protein poly-ADP-ribosylation)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0033148"(positive regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0070213"(protein auto-ADP-ribosylation)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0034644"(cellular response to UV)|go:"GO:0071294"(cellular response to zinc ion)|go:"GO:0090734"(site of DNA damage)|go:"GO:0140294"(NAD DNA ADP-ribosyltransferase activity)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1903376"(regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903518"(positive regulation of single strand break repair)|go:"GO:1904044"(response to aldosterone)|go:"GO:1904357"(negative regulation of telomere maintenance via telomere lengthening)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904762"(positive regulation of myofibroblast differentiation)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|go:"GO:1990404"(protein ADP-ribosylase activity)|go:"GO:1990966"(ATP generation from poly-ADP-D-ribose)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|go:"GO:2001170"(negative regulation of ATP biosynthetic process)|interpro:IPR001357(BRCT)|interpro:IPR001510(Zinc finger, PARP-type)|interpro:IPR004102("Poly(ADP-ribose) polymerase, regulatory region")|interpro:IPR008288(NAD+ ADP-ribosyltransferase)|interpro:IPR008893(WGR)|interpro:IPR012317("Poly(ADP-ribose) polymerase, catalytic region")|interpro:IPR012982(PADR1)|interpro:IPR036420|interpro:IPR036616|interpro:IPR036930|interpro:IPR036957|interpro:IPR038650|mint:P09874|rcsb pdb:1UK0|rcsb pdb:1UK1|rcsb pdb:1WOK|rcsb pdb:2COK|rcsb pdb:2CR9|rcsb pdb:2CS2|rcsb pdb:2DMJ|rcsb pdb:2JVN|go:"GO:1903827"|rcsb pdb:2L30|rcsb pdb:2N8A|rcsb pdb:2RCW|rcsb pdb:2RD6|rcsb pdb:2RIQ|rcsb pdb:2L31|rcsb pdb:3GJW|rcsb pdb:3GN7|rcsb pdb:3L3L|rcsb pdb:3L3M|rcsb pdb:3OD8|rcsb pdb:3ODA|rcsb pdb:3ODC|rcsb pdb:3ODE|rcsb pdb:4AV1|rcsb pdb:4DQY|rcsb pdb:4GV7|rcsb pdb:4HHY|rcsb pdb:4HHZ|rcsb pdb:4L6S|rcsb pdb:4OPX|rcsb pdb:4OQA|rcsb pdb:4OQB|rcsb pdb:4PJT|rcsb pdb:4R5W|rcsb pdb:4R6E|rcsb pdb:4RV6|rcsb pdb:4UND|rcsb pdb:4UXB|rcsb pdb:4XHU|rcsb pdb:5A00|rcsb pdb:5DS3|rcsb pdb:5HA9|rcsb pdb:5KPN|rcsb pdb:5KPO|rcsb pdb:5KPP|rcsb pdb:5KPQ|rcsb pdb:5WRQ|rcsb pdb:5WRY|rcsb pdb:5WRZ|rcsb pdb:5WS0|rcsb pdb:5WS1|rcsb pdb:5WTC|rcsb pdb:4ZZZ|rcsb pdb:5XSR|rcsb pdb:5XST|rcsb pdb:5XSU|rcsb pdb:6BHV|rcsb pdb:6GHK|rcsb pdb:6M3I|rcsb pdb:6NRF|rcsb pdb:6NRG|rcsb pdb:6NRH|rcsb pdb:6NRI|dip:DIP-38N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:91IyxhRDumStuUMNS8qNaB8SUMA9606 rogid:VC+4HLilGJuoiTbk4/fSeRw9+iY9606 intact-crc:32BD0EF074697E39|rigid:oMf3U5csDW3cQ3wR12IV6rc5UME false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9P275 uniprotkb:Q8N594 intact:EBI-2512419|ensembl:ENSP00000310590|ensembl:ENSP00000441214|ensembl:ENSP00000467280|uniprotkb:Q8NDM8|uniprotkb:Q05DD0|uniprotkb:Q9NVC8|uniprotkb:Q05C98|uniprotkb:Q6IQ38 intact:EBI-2512452|ensembl:ENSP00000262966|uniprotkb:Q96SJ0|uniprotkb:Q9Y2P1|uniprotkb:Q9Y2P2 psi-mi:ubp36_human(display_long)|uniprotkb:USP36(gene name)|psi-mi:USP36(display_short)|uniprotkb:KIAA1453(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 36(gene name synonym)|uniprotkb:Deubiquitinating enzyme 36(gene name synonym)|uniprotkb:Ubiquitin thioesterase 36(gene name synonym) psi-mi:mpnd_human(display_long)|uniprotkb:MPND(gene name)|psi-mi:MPND(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512446|imex:IM-12079-73 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000055483(gene)|ensembl:ENST00000312010(transcript)|ensembl:ENST00000542802(transcript)|ensembl:ENST00000589225(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007000"(nucleolus organization)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0016578"(histone deubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0016607"(nuclear speck)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0050821"(protein stabilization)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:2000232"(regulation of rRNA processing)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|refseq:XP_005257599.1|refseq:XP_005257600.1|refseq:XP_016880389.1|refseq:NP_001308220.1 ensembl:ENSG00000008382(gene)|ensembl:ENST00000262966(transcript)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0042393"(histone binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0070122"(isopeptidase activity)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR037518|interpro:IPR040843|mint:Q8N594|refseq:NP_001153318.1|refseq:NP_116257.2 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:91IyxhRDumStuUMNS8qNaB8SUMA9606 rogid:pkgiV58o6A8/jxIH3+E5PnhvrXk9606 intact-crc:32BD0EF074697E39|rigid:oMf3U5csDW3cQ3wR12IV6rc5UME false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9P275 uniprotkb:Q5H9R7 intact:EBI-2512419|ensembl:ENSP00000310590|ensembl:ENSP00000441214|ensembl:ENSP00000467280|uniprotkb:Q8NDM8|uniprotkb:Q05DD0|uniprotkb:Q9NVC8|uniprotkb:Q05C98|uniprotkb:Q6IQ38 intact:EBI-355498|uniprotkb:Q3B7I1|uniprotkb:Q7L4R8|uniprotkb:Q8N3B2|uniprotkb:Q96MB2|uniprotkb:Q9H2K5|uniprotkb:Q9H2K6|uniprotkb:Q9HCL4|uniprotkb:Q9NUY3|uniprotkb:Q3I4Y0|uniprotkb:Q3KR35|uniprotkb:Q68CR3|intact:EBI-28971860|ensembl:ENSP00000377389 psi-mi:ubp36_human(display_long)|uniprotkb:USP36(gene name)|psi-mi:USP36(display_short)|uniprotkb:KIAA1453(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 36(gene name synonym)|uniprotkb:Deubiquitinating enzyme 36(gene name synonym)|uniprotkb:Ubiquitin thioesterase 36(gene name synonym) psi-mi:pp6r3_human(display_long)|uniprotkb:PPP6R3(gene name)|psi-mi:PPP6R3(display_short)|uniprotkb:C11orf23(gene name synonym)|uniprotkb:KIAA1558(gene name synonym)|uniprotkb:PP6R3(gene name synonym)|uniprotkb:SAPL(gene name synonym)|uniprotkb:Sporulation-induced transcript 4-associated protein SAPL(gene name synonym)|uniprotkb:SAPS domain family member 3(gene name synonym)|uniprotkb:SAPS3(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512446|imex:IM-12079-73 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000055483(gene)|ensembl:ENST00000312010(transcript)|ensembl:ENST00000542802(transcript)|ensembl:ENST00000589225(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007000"(nucleolus organization)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0016578"(histone deubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0016607"(nuclear speck)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0050821"(protein stabilization)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:2000232"(regulation of rRNA processing)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|refseq:XP_005257599.1|refseq:XP_005257600.1|refseq:XP_016880389.1|refseq:NP_001308220.1 refseq:NP_001157632.1|refseq:NP_001157633.1|refseq:NP_001157634.1|refseq:NP_001157635.1|refseq:NP_001157636.1|refseq:NP_060782.2|ensembl:ENST00000265636|ensembl:ENSP00000265636|ensembl:ENSP00000377389|ensembl:ENST00000393801|ensembl:ENSP00000377390|ensembl:ENST00000524845|ensembl:ENSP00000431415|ensembl:ENST00000524904|ensembl:ENSP00000433058|ensembl:ENST00000529710|ensembl:ENSP00000437329|refseq:XP_011543442.1|refseq:XP_006718676.1|refseq:XP_006718677.1|refseq:XP_006718681.1|refseq:XP_006718687.1|refseq:XP_016873451.1|refseq:XP_016873452.1|refseq:XP_016873455.1|ensembl:ENSG00000110075(gene)|ensembl:ENST00000393800(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|interpro:IPR007587(SIT4 phosphatase-associated protein)|interpro:IPR016024(Armadillo-type fold)|mint:Q5H9R7|reactome:R-HSA-171319|reactome:R-HSA-204005 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:91IyxhRDumStuUMNS8qNaB8SUMA9606 rogid:9hU14AmzYI9nORfchfMtLoyRecA9606 intact-crc:32BD0EF074697E39|rigid:oMf3U5csDW3cQ3wR12IV6rc5UME false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9P275 uniprotkb:Q12788 intact:EBI-2512419|ensembl:ENSP00000310590|ensembl:ENSP00000441214|ensembl:ENSP00000467280|uniprotkb:Q8NDM8|uniprotkb:Q05DD0|uniprotkb:Q9NVC8|uniprotkb:Q05C98|uniprotkb:Q6IQ38 intact:EBI-715766|uniprotkb:Q59GD6|uniprotkb:Q8IVB7|intact:EBI-749106|uniprotkb:Q96A78|ensembl:ENSP00000454836 psi-mi:ubp36_human(display_long)|uniprotkb:USP36(gene name)|psi-mi:USP36(display_short)|uniprotkb:KIAA1453(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 36(gene name synonym)|uniprotkb:Deubiquitinating enzyme 36(gene name synonym)|uniprotkb:Ubiquitin thioesterase 36(gene name synonym) psi-mi:tbl3_human(display_long)|uniprotkb:WD repeat-containing protein SAZD(gene name synonym)|uniprotkb:TBL3(gene name)|psi-mi:TBL3(display_short)|uniprotkb:SAZD(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512446|imex:IM-12079-73 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000055483(gene)|ensembl:ENST00000312010(transcript)|ensembl:ENST00000542802(transcript)|ensembl:ENST00000589225(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007000"(nucleolus organization)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0016578"(histone deubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0016607"(nuclear speck)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0050821"(protein stabilization)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:2000232"(regulation of rRNA processing)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|refseq:XP_005257599.1|refseq:XP_005257600.1|refseq:XP_016880389.1|refseq:NP_001308220.1 refseq:NP_006444.2|ensembl:ENSG00000183751(gene)|ensembl:ENST00000568546(transcript)|go:"GO:0000472"("endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0000480"("endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0030686"(90S preribosome)|go:"GO:0032040"(small-subunit processome)|go:"GO:0034511"(U3 snoRNA binding)|interpro:IPR001680(WD40 repeat)|interpro:IPR011044(Quinoprotein amine dehydrogenase, beta chain-like)|interpro:IPR013934(Small-subunit processome, Utp13)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|mint:Q12788|reactome:R-HSA-6790901|reactome:R-HSA-6791226 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:91IyxhRDumStuUMNS8qNaB8SUMA9606 rogid:XFWYZxef3kNBYeTaoSBWEXQoF/M9606 intact-crc:32BD0EF074697E39|rigid:oMf3U5csDW3cQ3wR12IV6rc5UME false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9P275 uniprotkb:O00506 intact:EBI-2512419|ensembl:ENSP00000310590|ensembl:ENSP00000441214|ensembl:ENSP00000467280|uniprotkb:Q8NDM8|uniprotkb:Q05DD0|uniprotkb:Q9NVC8|uniprotkb:Q05C98|uniprotkb:Q6IQ38 intact:EBI-618295|ensembl:ENSP00000325748|ensembl:ENSP00000384162|ensembl:ENSP00000385687|uniprotkb:Q15522|uniprotkb:Q5BJF1|uniprotkb:A8K7D2|intact:EBI-5773834|uniprotkb:A8K6Z3|uniprotkb:B7Z9K1 psi-mi:ubp36_human(display_long)|uniprotkb:USP36(gene name)|psi-mi:USP36(display_short)|uniprotkb:KIAA1453(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 36(gene name synonym)|uniprotkb:Deubiquitinating enzyme 36(gene name synonym)|uniprotkb:Ubiquitin thioesterase 36(gene name synonym) psi-mi:stk25_human(display_long)|uniprotkb:STK25(gene name)|psi-mi:STK25(display_short)|uniprotkb:SOK1(gene name synonym)|uniprotkb:YSK1(gene name synonym)|uniprotkb:Sterile 20/oxidant stress-response kinase 1(gene name synonym)|uniprotkb:Ste20-like kinase(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512446|imex:IM-12079-73 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000055483(gene)|ensembl:ENST00000312010(transcript)|ensembl:ENST00000542802(transcript)|ensembl:ENST00000589225(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007000"(nucleolus organization)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0016578"(histone deubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0016607"(nuclear speck)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0050821"(protein stabilization)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:2000232"(regulation of rRNA processing)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|refseq:XP_005257599.1|refseq:XP_005257600.1|refseq:XP_016880389.1|refseq:NP_001308220.1 ensembl:ENSG00000115694(gene)|ensembl:ENST00000316586(transcript)|ensembl:ENST00000401869(transcript)|ensembl:ENST00000403346(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007165"(signal transduction)|go:"GO:0032874"(positive regulation of stress-activated MAPK cascade)|go:"GO:0036481"(intrinsic apoptotic signaling pathway in response to hydrogen peroxide)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0051645"(Golgi localization)|go:"GO:0051683"(establishment of Golgi localization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090168"(Golgi reassembly)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR035060|rcsb pdb:2XIK|rcsb pdb:3W8H|rcsb pdb:4NZW|refseq:NP_006365.2|refseq:NP_001258908.1|refseq:NP_001258909.1|refseq:NP_001269234.1|refseq:NP_001269237.1|refseq:NP_001269236.1|refseq:NP_001258906.1|refseq:NP_001258907.1|dip:DIP-34269N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:91IyxhRDumStuUMNS8qNaB8SUMA9606 rogid:yg5mghaePpT2LrC7wdG7xSGe0Pw9606 intact-crc:32BD0EF074697E39|rigid:oMf3U5csDW3cQ3wR12IV6rc5UME false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9P275 uniprotkb:Q8NE00 intact:EBI-2512419|ensembl:ENSP00000310590|ensembl:ENSP00000441214|ensembl:ENSP00000467280|uniprotkb:Q8NDM8|uniprotkb:Q05DD0|uniprotkb:Q9NVC8|uniprotkb:Q05C98|uniprotkb:Q6IQ38 intact:EBI-2512439|uniprotkb:Q8TEU1|uniprotkb:Q9NT56|uniprotkb:Q9NXH1|ensembl:ENSP00000334849|ensembl:ENSP00000461922 psi-mi:ubp36_human(display_long)|uniprotkb:USP36(gene name)|psi-mi:USP36(display_short)|uniprotkb:KIAA1453(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 36(gene name synonym)|uniprotkb:Deubiquitinating enzyme 36(gene name synonym)|uniprotkb:Ubiquitin thioesterase 36(gene name synonym) psi-mi:tm104_human(display_long)|uniprotkb:TMEM104(gene name)|psi-mi:TMEM104(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512446|imex:IM-12079-73 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000055483(gene)|ensembl:ENST00000312010(transcript)|ensembl:ENST00000542802(transcript)|ensembl:ENST00000589225(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007000"(nucleolus organization)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0016578"(histone deubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0016607"(nuclear speck)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0050821"(protein stabilization)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:2000232"(regulation of rRNA processing)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|refseq:XP_005257599.1|refseq:XP_005257600.1|refseq:XP_016880389.1|refseq:NP_001308220.1 refseq:NP_001308193.1|refseq:NP_060198.3|ensembl:ENSG00000109066(gene)|ensembl:ENST00000335464(transcript)|ensembl:ENST00000582330(transcript)|go:"GO:0016021"(integral component of membrane)|interpro:IPR013057(Amino acid transporter, transmembrane) psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:91IyxhRDumStuUMNS8qNaB8SUMA9606 rogid:lEoO0wj7uUjCD6ndDKAhyZFXrss9606 intact-crc:32BD0EF074697E39|rigid:oMf3U5csDW3cQ3wR12IV6rc5UME false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9P275 uniprotkb:Q12894 intact:EBI-2512419|ensembl:ENSP00000310590|ensembl:ENSP00000441214|ensembl:ENSP00000467280|uniprotkb:Q8NDM8|uniprotkb:Q05DD0|uniprotkb:Q9NVC8|uniprotkb:Q05C98|uniprotkb:Q6IQ38 intact:EBI-2512448|ensembl:ENSP00000402849|intact:EBI-6115935|uniprotkb:Q9BVB4|uniprotkb:Q9UJ88 psi-mi:ubp36_human(display_long)|uniprotkb:USP36(gene name)|psi-mi:USP36(display_short)|uniprotkb:KIAA1453(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 36(gene name synonym)|uniprotkb:Deubiquitinating enzyme 36(gene name synonym)|uniprotkb:Ubiquitin thioesterase 36(gene name synonym) psi-mi:ifrd2_human(display_long)|uniprotkb:Protein SKMC15(gene name synonym)|uniprotkb:IFRD2(gene name)|psi-mi:IFRD2(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512446|imex:IM-12079-73 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000055483(gene)|ensembl:ENST00000312010(transcript)|ensembl:ENST00000542802(transcript)|ensembl:ENST00000589225(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007000"(nucleolus organization)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0016578"(histone deubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0016607"(nuclear speck)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0050821"(protein stabilization)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:2000232"(regulation of rRNA processing)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|refseq:XP_005257599.1|refseq:XP_005257600.1|refseq:XP_016880389.1|refseq:NP_001308220.1 ensembl:ENSG00000214706(gene)|ensembl:ENST00000417626(transcript)|go:"GO:0005634"(nucleus)|interpro:IPR006921(Interferon-related protein conserved region)|interpro:IPR007701(Interferon-related developmental regulator)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR039777|refseq:NP_006755.4 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:91IyxhRDumStuUMNS8qNaB8SUMA9606 rogid:ktxpbUgNcw2DWOJw8o1R4s+U3a09606 intact-crc:32BD0EF074697E39|rigid:oMf3U5csDW3cQ3wR12IV6rc5UME false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9P275 uniprotkb:Q9H6R0 intact:EBI-2512419|ensembl:ENSP00000310590|ensembl:ENSP00000441214|ensembl:ENSP00000467280|uniprotkb:Q8NDM8|uniprotkb:Q05DD0|uniprotkb:Q9NVC8|uniprotkb:Q05C98|uniprotkb:Q6IQ38 intact:EBI-2512405|ensembl:ENSP00000225296|uniprotkb:Q4G149|uniprotkb:B4DHF9|uniprotkb:Q5CZ73|uniprotkb:Q9H5M9 psi-mi:ubp36_human(display_long)|uniprotkb:USP36(gene name)|psi-mi:USP36(display_short)|uniprotkb:KIAA1453(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 36(gene name synonym)|uniprotkb:Deubiquitinating enzyme 36(gene name synonym)|uniprotkb:Ubiquitin thioesterase 36(gene name synonym) psi-mi:dhx33_human(display_long)|uniprotkb:DHX33(gene name)|psi-mi:DHX33(display_short)|uniprotkb:DDX33(gene name synonym)|uniprotkb:DEAH box protein 33(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512446|imex:IM-12079-73 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000055483(gene)|ensembl:ENST00000312010(transcript)|ensembl:ENST00000542802(transcript)|ensembl:ENST00000589225(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007000"(nucleolus organization)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0016578"(histone deubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0016607"(nuclear speck)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0050821"(protein stabilization)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:2000232"(regulation of rRNA processing)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|refseq:XP_005257599.1|refseq:XP_005257600.1|refseq:XP_016880389.1|refseq:NP_001308220.1 ensembl:ENSG00000005100(gene)|ensembl:ENST00000225296(transcript)|go:"GO:0000182"(rDNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006413"(translational initiation)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0043023"(ribosomal large subunit binding)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045943"(positive regulation of transcription by RNA polymerase I)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0072559"(NLRP3 inflammasome complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR002464(DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site)|interpro:IPR007502(Helicase-associated region)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR011709(Region of unknown function DUF1605)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR027417|mint:Q9H6R0|refseq:NP_001186628.1|refseq:NP_064547.2|refseq:XP_016880366.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:91IyxhRDumStuUMNS8qNaB8SUMA9606 rogid:jR/BdCPb1fZgJxOWaxNRfqo0AvQ9606 intact-crc:32BD0EF074697E39|rigid:oMf3U5csDW3cQ3wR12IV6rc5UME false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9P275 uniprotkb:Q8NI36 intact:EBI-2512419|ensembl:ENSP00000310590|ensembl:ENSP00000441214|ensembl:ENSP00000467280|uniprotkb:Q8NDM8|uniprotkb:Q05DD0|uniprotkb:Q9NVC8|uniprotkb:Q05C98|uniprotkb:Q6IQ38 intact:EBI-2512413|ensembl:ENSP00000423067|ensembl:ENSP00000479950|uniprotkb:A2RUS4|uniprotkb:Q8N1Q2|uniprotkb:Q68E02 psi-mi:ubp36_human(display_long)|uniprotkb:USP36(gene name)|psi-mi:USP36(display_short)|uniprotkb:KIAA1453(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 36(gene name synonym)|uniprotkb:Deubiquitinating enzyme 36(gene name synonym)|uniprotkb:Ubiquitin thioesterase 36(gene name synonym) psi-mi:wdr36_human(display_long)|uniprotkb:WDR36(gene name)|psi-mi:WDR36(display_short)|uniprotkb:T-cell activation WD repeat-containing protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512446|imex:IM-12079-73 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000055483(gene)|ensembl:ENST00000312010(transcript)|ensembl:ENST00000542802(transcript)|ensembl:ENST00000589225(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007000"(nucleolus organization)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0016578"(histone deubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0016607"(nuclear speck)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0050821"(protein stabilization)|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:2000232"(regulation of rRNA processing)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|refseq:XP_005257599.1|refseq:XP_005257600.1|refseq:XP_016880389.1|refseq:NP_001308220.1 ensembl:ENSG00000134987(gene)|ensembl:ENST00000506538(transcript)|ensembl:ENST00000612402(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006364"(rRNA processing)|go:"GO:0007601"(visual perception)|go:"GO:0032040"(small-subunit processome)|go:"GO:0034388"(Pwp2p-containing subcomplex of 90S preribosome)|go:"GO:0050896"(response to stimulus)|interpro:IPR001680(WD40 repeat)|interpro:IPR007319(Small-subunit processome, Utp21)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR024977|interpro:IPR036322|reactome:R-HSA-6790901|reactome:R-HSA-6791226|go:"GO:0003723"(RNA binding)|refseq:NP_644810.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:91IyxhRDumStuUMNS8qNaB8SUMA9606 rogid:97Qc0ehUPTjCBcn3gjr0FY8Nnus9606 intact-crc:32BD0EF074697E39|rigid:oMf3U5csDW3cQ3wR12IV6rc5UME false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NB14 uniprotkb:P47929 intact:EBI-2512509|ensembl:ENSP00000303434|uniprotkb:Q9BY55|uniprotkb:Q96PZ6|uniprotkb:Q8NDF5|uniprotkb:B3KX93|uniprotkb:Q96DK6|uniprotkb:Q3ZCV1 intact:EBI-357504|ensembl:ENSP00000313571|ensembl:ENSP00000367891|ensembl:ENSP00000489395|ensembl:ENSP00000489582|uniprotkb:Q6IB87 psi-mi:ubp38_human(display_long)|uniprotkb:USP38(gene name)|psi-mi:USP38(display_short)|uniprotkb:KIAA1891(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 38(gene name synonym)|uniprotkb:Deubiquitinating enzyme 38(gene name synonym)|uniprotkb:HP43.8KD(gene name synonym)|uniprotkb:Ubiquitin thioesterase 38(gene name synonym) psi-mi:leg7_human(display_long)|uniprotkb:LGALS7(gene name)|psi-mi:LGALS7(display_short)|uniprotkb:PIG1(gene name synonym)|uniprotkb:HKL-14(gene name synonym)|uniprotkb:PI7(gene name synonym)|uniprotkb:p53-induced gene 1 protein(gene name synonym)|uniprotkb:LGALS7B(gene name)|psi-mi:LGALS7B(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512519|imex:IM-12079-23 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000170185(gene)|ensembl:ENST00000307017(transcript)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR033840|go:"GO:0016579"(protein deubiquitination)|interpro:IPR038765|rcsb pdb:4RXX|refseq:NP_001277254.1|refseq:NP_001277255.1|refseq:NP_115946.2 ensembl:ENSG00000178934(gene)|ensembl:ENSG00000205076(gene)|ensembl:ENSG00000282902(gene)|ensembl:ENSG00000283082(gene)|ensembl:ENST00000314980(transcript)|ensembl:ENST00000378626(transcript)|ensembl:ENST00000634448(transcript)|ensembl:ENST00000634800(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016936"(galactoside binding)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0070062"(extracellular exosome)|go:"GO:2000562"(negative regulation of CD4-positive, alpha-beta T cell proliferation)|interpro:IPR001079(Galectin, galactose-binding lectin)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR030640|interpro:IPR044156|mint:P47929|rcsb pdb:1BKZ|rcsb pdb:2GAL|rcsb pdb:3GAL|rcsb pdb:3ZXE|rcsb pdb:3ZXF|rcsb pdb:4GAL|rcsb pdb:4UW3|rcsb pdb:4UW4|rcsb pdb:4UW5|rcsb pdb:4UW6|rcsb pdb:4XBQ|rcsb pdb:4Y26|rcsb pdb:5GAL|rcsb pdb:5H9Q|rcsb pdb:5H9S|refseq:NP_001035972.1|refseq:NP_002298.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:huO1Ev3rX0NZ/kNU5vtcNUfqTtw9606 rogid:TIAlvVZ7rOYqTAGrYAFbJY231gc9606 intact-crc:D0BFF36C017CB8DE|rigid:V+HAaDAJprVnpUVZThnEWKkf9s8 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NB14 uniprotkb:P18124 intact:EBI-2512509|ensembl:ENSP00000303434|uniprotkb:Q9BY55|uniprotkb:Q96PZ6|uniprotkb:Q8NDF5|uniprotkb:B3KX93|uniprotkb:Q96DK6|uniprotkb:Q3ZCV1 intact:EBI-350806|uniprotkb:Q3KQU0|uniprotkb:Q15289|uniprotkb:Q5I0X1|uniprotkb:Q6IBM9|uniprotkb:A8K504|ensembl:ENSP00000339795 psi-mi:ubp38_human(display_long)|uniprotkb:USP38(gene name)|psi-mi:USP38(display_short)|uniprotkb:KIAA1891(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 38(gene name synonym)|uniprotkb:Deubiquitinating enzyme 38(gene name synonym)|uniprotkb:HP43.8KD(gene name synonym)|uniprotkb:Ubiquitin thioesterase 38(gene name synonym) psi-mi:rl7_human(display_long)|uniprotkb:RPL7(gene name)|psi-mi:RPL7(display_short)|uniprotkb:Large ribosomal subunit protein uL30(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512519|imex:IM-12079-23 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000170185(gene)|ensembl:ENST00000307017(transcript)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR033840|go:"GO:0016579"(protein deubiquitination)|interpro:IPR038765|rcsb pdb:4RXX|refseq:NP_001277254.1|refseq:NP_001277255.1|refseq:NP_115946.2 refseq:NP_000962.2|ensembl:ENSG00000147604(gene)|ensembl:ENST00000352983(transcript)|go:"GO:0000463"("maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006364"(rRNA processing)|go:"GO:0006412"(translation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0042273"(ribosomal large subunit biogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR005998(Ribosomal protein L7, eukaryotic)|interpro:IPR012988(Ribosomal protein L30, N-terminal)|interpro:IPR016082(Ribosomal protein L30, C-terminal)|interpro:IPR018038|interpro:IPR035808|interpro:IPR036919|interpro:IPR039699|mint:P18124|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5AJ0|rcsb pdb:5LKS|rcsb pdb:5T2C|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6LU8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6W6L|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6Y6X|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:7BHP|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|reactome:R-HSA-72689 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:huO1Ev3rX0NZ/kNU5vtcNUfqTtw9606 rogid:miVEaLOilDYcZXshxJlYbpnzwZ89606 intact-crc:D0BFF36C017CB8DE|rigid:V+HAaDAJprVnpUVZThnEWKkf9s8 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NB14 uniprotkb:P04792 intact:EBI-2512509|ensembl:ENSP00000303434|uniprotkb:Q9BY55|uniprotkb:Q96PZ6|uniprotkb:Q8NDF5|uniprotkb:B3KX93|uniprotkb:Q96DK6|uniprotkb:Q3ZCV1 intact:EBI-352682|uniprotkb:Q6FI47|uniprotkb:Q96C20|uniprotkb:Q96EI7|uniprotkb:Q9UC34|uniprotkb:Q9UC35|uniprotkb:Q9UC36|uniprotkb:Q9UC31|ensembl:ENSP00000248553|uniprotkb:B2R4N8 psi-mi:ubp38_human(display_long)|uniprotkb:USP38(gene name)|psi-mi:USP38(display_short)|uniprotkb:KIAA1891(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 38(gene name synonym)|uniprotkb:Deubiquitinating enzyme 38(gene name synonym)|uniprotkb:HP43.8KD(gene name synonym)|uniprotkb:Ubiquitin thioesterase 38(gene name synonym) psi-mi:hspb1_human(display_long)|uniprotkb:HSPB1(gene name)|psi-mi:HSPB1(display_short)|uniprotkb:HSP27(gene name synonym)|uniprotkb:HSP28(gene name synonym)|uniprotkb:Heat shock 27 kDa protein(gene name synonym)|uniprotkb:Stress-responsive protein 27(gene name synonym)|uniprotkb:Estrogen-regulated 24 kDa protein(gene name synonym)|uniprotkb:28 kDa heat shock protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512519|imex:IM-12079-23 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000170185(gene)|ensembl:ENST00000307017(transcript)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR033840|go:"GO:0016579"(protein deubiquitination)|interpro:IPR038765|rcsb pdb:4RXX|refseq:NP_001277254.1|refseq:NP_001277255.1|refseq:NP_115946.2 refseq:NP_001531.1|ensembl:ENSG00000106211(gene)|ensembl:ENST00000248553(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0001895"(retina homeostasis)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0008426"(protein kinase C inhibitor activity)|go:"GO:0009615"(response to virus)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0038033"(positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:0099641"(anterograde axonal protein transport)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1904115"(axon cytoplasm)|go:"GO:2001028"(positive regulation of endothelial cell chemotaxis)|interpro:IPR001436(Alpha crystallin/Heat shock protein)|interpro:IPR002068(Heat shock protein Hsp20)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR037876|mint:P04792|rcsb pdb:2N3J|rcsb pdb:3Q9P|rcsb pdb:3Q9Q|rcsb pdb:4MJH|rcsb pdb:6DV5|rcsb pdb:6GJH|reactome:R-HSA-4420097|reactome:R-HSA-450408|reactome:R-HSA-5687128|reactome:R-HSA-9009391|dip:DIP-412N psi-mi:"MI:0469"(intact) - crc64:1B4DC44A6F6606D5 figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:huO1Ev3rX0NZ/kNU5vtcNUfqTtw9606 rogid:vrDXIdzP30aHSDLHOh2D4x54eJY9606 intact-crc:D0BFF36C017CB8DE|rigid:V+HAaDAJprVnpUVZThnEWKkf9s8 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NB14 uniprotkb:A2RU54 intact:EBI-2512509|ensembl:ENSP00000303434|uniprotkb:Q9BY55|uniprotkb:Q96PZ6|uniprotkb:Q8NDF5|uniprotkb:B3KX93|uniprotkb:Q96DK6|uniprotkb:Q3ZCV1 intact:EBI-2511017|ensembl:ENSP00000341108|uniprotkb:B2RNV5 psi-mi:ubp38_human(display_long)|uniprotkb:USP38(gene name)|psi-mi:USP38(display_short)|uniprotkb:KIAA1891(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 38(gene name synonym)|uniprotkb:Deubiquitinating enzyme 38(gene name synonym)|uniprotkb:HP43.8KD(gene name synonym)|uniprotkb:Ubiquitin thioesterase 38(gene name synonym) psi-mi:hmx2_human(display_long)|uniprotkb:HMX2(gene name)|psi-mi:HMX2(display_short)|uniprotkb:Homeobox protein H6 family member 2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512519|imex:IM-12079-23 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000170185(gene)|ensembl:ENST00000307017(transcript)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR033840|go:"GO:0016579"(protein deubiquitination)|interpro:IPR038765|rcsb pdb:4RXX|refseq:NP_001277254.1|refseq:NP_001277255.1|refseq:NP_115946.2 ensembl:ENSG00000188816(gene)|ensembl:ENST00000339992(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007420"(brain development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0030154"(cell differentiation)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0048026"(positive regulation of mRNA splicing, via spliceosome)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|interpro:IPR020479|refseq:NP_005510.1|refseq:XP_005269800.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:huO1Ev3rX0NZ/kNU5vtcNUfqTtw9606 rogid:rMmysvirF2yrqZCZdnEUp5M/0fM9606 intact-crc:D0BFF36C017CB8DE|rigid:V+HAaDAJprVnpUVZThnEWKkf9s8 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NB14 intact:EBI-2507570 intact:EBI-2512509|ensembl:ENSP00000303434|uniprotkb:Q9BY55|uniprotkb:Q96PZ6|uniprotkb:Q8NDF5|uniprotkb:B3KX93|uniprotkb:Q96DK6|uniprotkb:Q3ZCV1 uniparc:UPI0000D62420 psi-mi:ubp38_human(display_long)|uniprotkb:USP38(gene name)|psi-mi:USP38(display_short)|uniprotkb:KIAA1891(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 38(gene name synonym)|uniprotkb:Deubiquitinating enzyme 38(gene name synonym)|uniprotkb:HP43.8KD(gene name synonym)|uniprotkb:Ubiquitin thioesterase 38(gene name synonym) psi-mi:ipi00332656(display_short)|psi-mi:EBI-2507570(display_long) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512519|imex:IM-12079-23 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000170185(gene)|ensembl:ENST00000307017(transcript)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR033840|go:"GO:0016579"(protein deubiquitination)|interpro:IPR038765|rcsb pdb:4RXX|refseq:NP_001277254.1|refseq:NP_001277255.1|refseq:NP_115946.2 - psi-mi:"MI:0469"(intact) - no-uniprot-update:An amino acid sequence which is not represented in UniProt figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:huO1Ev3rX0NZ/kNU5vtcNUfqTtw9606 rogid:/FjK8aGPpwE4ocMCbkzPh+XSZrU9606 intact-crc:D0BFF36C017CB8DE|rigid:V+HAaDAJprVnpUVZThnEWKkf9s8 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NB14 uniprotkb:P25398 intact:EBI-2512509|ensembl:ENSP00000303434|uniprotkb:Q9BY55|uniprotkb:Q96PZ6|uniprotkb:Q8NDF5|uniprotkb:B3KX93|uniprotkb:Q96DK6|uniprotkb:Q3ZCV1 intact:EBI-354542|uniprotkb:Q76M58|ensembl:ENSP00000230050 psi-mi:ubp38_human(display_long)|uniprotkb:USP38(gene name)|psi-mi:USP38(display_short)|uniprotkb:KIAA1891(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 38(gene name synonym)|uniprotkb:Deubiquitinating enzyme 38(gene name synonym)|uniprotkb:HP43.8KD(gene name synonym)|uniprotkb:Ubiquitin thioesterase 38(gene name synonym) psi-mi:rs12_human(display_long)|uniprotkb:RPS12(gene name)|psi-mi:RPS12(display_short)|uniprotkb:Small ribosomal subunit protein eS12(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512519|imex:IM-12079-23 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000170185(gene)|ensembl:ENST00000307017(transcript)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR033840|go:"GO:0016579"(protein deubiquitination)|interpro:IPR038765|rcsb pdb:4RXX|refseq:NP_001277254.1|refseq:NP_001277255.1|refseq:NP_115946.2 refseq:NP_001007.2|ensembl:ENSG00000112306(gene)|ensembl:ENST00000230050(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0016020"(membrane)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0022627"(cytosolic small ribosomal subunit)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|interpro:IPR000530(Ribosomal protein S12e)|interpro:IPR004038(Ribosomal protein L7Ae/L30e/S12e/Gadd45)|interpro:IPR029064|rcsb pdb:4V6X|rcsb pdb:5A2Q|rcsb pdb:5AJ0|rcsb pdb:5FLX|rcsb pdb:5LKS|rcsb pdb:5OA3|rcsb pdb:5T2C|rcsb pdb:5VYC|rcsb pdb:6EK0|rcsb pdb:6FEC|rcsb pdb:6G18|rcsb pdb:6G51|rcsb pdb:6G53|rcsb pdb:6G5H|rcsb pdb:6G5I|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y57|rcsb pdb:6YBS|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZLW|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:6ZMT|rcsb pdb:6ZMW|rcsb pdb:6ZN5|rcsb pdb:6ZOJ|rcsb pdb:6ZOL|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZUO|rcsb pdb:6ZV6|rcsb pdb:6ZVH|rcsb pdb:6ZVJ|rcsb pdb:6ZXD|rcsb pdb:6ZXE|rcsb pdb:6ZXF|rcsb pdb:6ZXG|rcsb pdb:6ZXH|rcsb pdb:7A09|rcsb pdb:7K5I|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72702|reactome:R-HSA-72695|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:huO1Ev3rX0NZ/kNU5vtcNUfqTtw9606 rogid:80AIouzSdCvnLUSA7qsMp6naZ3g9606 intact-crc:D0BFF36C017CB8DE|rigid:V+HAaDAJprVnpUVZThnEWKkf9s8 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q53GS9 uniprotkb:Q9UQ80 intact:EBI-1044822|uniprotkb:Q6NX47|uniprotkb:Q96RK9|uniprotkb:Q9BV89|uniprotkb:Q9H381|uniprotkb:Q9P050|uniprotkb:Q9Y310|uniprotkb:A8K086|ensembl:ENSP00000312981|ensembl:ENSP00000386864|uniprotkb:D6W5L4|intact:EBI-2557627|uniprotkb:B4DHT4|uniprotkb:B3KM40|uniprotkb:G5E9H0 intact:EBI-924893|uniprotkb:Q9UM59|uniprotkb:O43846|ensembl:ENSP00000302886 psi-mi:snut2_human(display_long)|uniprotkb:U4/U6.U5 tri-snRNP-associated 65 kDa protein(gene name synonym)|uniprotkb:Inactive ubiquitin-specific peptidase 39(gene name synonym)|uniprotkb:SAD1 homolog(gene name synonym)|uniprotkb:USP39(gene name)|psi-mi:USP39(display_short)|uniprotkb:CGI-21(orf name)|uniprotkb:HSPC332(orf name)|uniprotkb:PRO2855(orf name) psi-mi:pa2g4_human(display_long)|uniprotkb:PA2G4(gene name)|psi-mi:PA2G4(display_short)|uniprotkb:Cell cycle protein p38-2G4 homolog(gene name synonym)|uniprotkb:ErbB3-binding protein 1(gene name synonym)|uniprotkb:EBP1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512555|imex:IM-12079-74 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006581.2|go:"GO:0008270"(zinc ion binding)|go:"GO:0008380"(RNA splicing)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0051301"(cell division)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR028889|interpro:IPR033809|interpro:IPR038765|go:"GO:0007049"(cell cycle)|rcsb pdb:3JCR|rcsb pdb:6AH0|rcsb pdb:6QW6|rcsb pdb:6QX9|reactome:R-HSA-72163|ensembl:ENSG00000168883(gene)|ensembl:ENST00000323701(transcript)|ensembl:ENST00000409470(transcript)|go:"GO:0000245"(spliceosomal complex assembly)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0006397"(mRNA processing)|refseq:NP_001243656.1|refseq:NP_001243657.1|refseq:NP_001243654.1|refseq:NP_001243655.1|refseq:XP_006711985.1|refseq:XP_006711986.1|refseq:XP_011530789.1|refseq:XP_011530790.1|refseq:XP_016858671.1 refseq:NP_006182.2|dip:DIP-31275N|ensembl:ENSG00000170515(gene)|ensembl:ENST00000303305(transcript)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006364"(rRNA processing)|go:"GO:0006417"(regulation of translation)|go:"GO:0016020"(membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000994(Peptidase M24, catalytic core)|interpro:IPR004545(Proliferation-associated protein 1)|interpro:IPR036005|interpro:IPR036388|interpro:IPR036390|mint:Q9UQ80|rcsb pdb:2Q8K|rcsb pdb:3J2I|rcsb pdb:6CHT|rcsb pdb:6LSR|rcsb pdb:6SXO|rcsb pdb:6WM8|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:7BHP|reactome:R-HSA-6798695|interpro:IPR018349 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:AMLhskNenuv+zqXSa7VesSbbVK89606 rogid:OGRaz1uHilOnGXaAr/yeKMlCyns9606 intact-crc:0C994AD12CFA96BF|rigid:dXIDFwKFnSyKylhQY+vEZ/Pj2E4 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q53GS9 uniprotkb:Q96DI7 intact:EBI-1044822|uniprotkb:Q6NX47|uniprotkb:Q96RK9|uniprotkb:Q9BV89|uniprotkb:Q9H381|uniprotkb:Q9P050|uniprotkb:Q9Y310|uniprotkb:A8K086|ensembl:ENSP00000312981|ensembl:ENSP00000386864|uniprotkb:D6W5L4|intact:EBI-2557627|uniprotkb:B4DHT4|uniprotkb:B3KM40|uniprotkb:G5E9H0 intact:EBI-538492|uniprotkb:O75938|uniprotkb:O95320|uniprotkb:B4DQJ1|ensembl:ENSP00000263694 psi-mi:snut2_human(display_long)|uniprotkb:U4/U6.U5 tri-snRNP-associated 65 kDa protein(gene name synonym)|uniprotkb:Inactive ubiquitin-specific peptidase 39(gene name synonym)|uniprotkb:SAD1 homolog(gene name synonym)|uniprotkb:USP39(gene name)|psi-mi:USP39(display_short)|uniprotkb:CGI-21(orf name)|uniprotkb:HSPC332(orf name)|uniprotkb:PRO2855(orf name) psi-mi:snr40_human(display_long)|uniprotkb:Prp8-binding protein(gene name synonym)|uniprotkb:U5 snRNP-specific 40 kDa protein(gene name synonym)|uniprotkb:38 kDa-splicing factor(gene name synonym)|uniprotkb:SNRNP40(gene name)|psi-mi:SNRNP40(display_short)|uniprotkb:PRP8BP(gene name synonym)|uniprotkb:SFP38(gene name synonym)|uniprotkb:WDR57(gene name synonym)|uniprotkb:WD repeat-containing protein 57(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512555|imex:IM-12079-74 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006581.2|go:"GO:0008270"(zinc ion binding)|go:"GO:0008380"(RNA splicing)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0051301"(cell division)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR028889|interpro:IPR033809|interpro:IPR038765|go:"GO:0007049"(cell cycle)|rcsb pdb:3JCR|rcsb pdb:6AH0|rcsb pdb:6QW6|rcsb pdb:6QX9|reactome:R-HSA-72163|ensembl:ENSG00000168883(gene)|ensembl:ENST00000323701(transcript)|ensembl:ENST00000409470(transcript)|go:"GO:0000245"(spliceosomal complex assembly)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0006397"(mRNA processing)|refseq:NP_001243656.1|refseq:NP_001243657.1|refseq:NP_001243654.1|refseq:NP_001243655.1|refseq:XP_006711985.1|refseq:XP_006711986.1|refseq:XP_011530789.1|refseq:XP_011530790.1|refseq:XP_016858671.1 refseq:NP_004805.2|ensembl:ENSG00000060688(gene)|ensembl:ENST00000263694(transcript)|go:"GO:0000375"(RNA splicing, via transesterification reactions)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005682"(U5 snRNP)|go:"GO:0005732"("sno(s)RNA-containing ribonucleoprotein complex")|go:"GO:0005829"(cytosol)|go:"GO:0006396"(RNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0016607"(nuclear speck)|go:"GO:0071007"(U2-type catalytic step 2 spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|mint:Q96DI7|rcsb pdb:3JCR|rcsb pdb:5MQF|rcsb pdb:5O9Z|rcsb pdb:5XJC|rcsb pdb:5YZG|rcsb pdb:5Z56|rcsb pdb:5Z57|rcsb pdb:5Z58|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6FF7|rcsb pdb:6ICZ|rcsb pdb:6ID0|rcsb pdb:6ID1|rcsb pdb:6QDV|rcsb pdb:6QW6|rcsb pdb:6QX9|rcsb pdb:6ZYM|rcsb pdb:7ABG|rcsb pdb:7ABI|rcsb pdb:7DVQ|reactome:R-HSA-72163|reactome:R-HSA-72165 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:AMLhskNenuv+zqXSa7VesSbbVK89606 rogid:AfLoHYSy0MlW+OqHyEULLcpwQhQ9606 intact-crc:0C994AD12CFA96BF|rigid:dXIDFwKFnSyKylhQY+vEZ/Pj2E4 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q53GS9 uniprotkb:Q9BUQ8 intact:EBI-1044822|uniprotkb:Q6NX47|uniprotkb:Q96RK9|uniprotkb:Q9BV89|uniprotkb:Q9H381|uniprotkb:Q9P050|uniprotkb:Q9Y310|uniprotkb:A8K086|ensembl:ENSP00000312981|ensembl:ENSP00000386864|uniprotkb:D6W5L4|intact:EBI-2557627|uniprotkb:B4DHT4|uniprotkb:B3KM40|uniprotkb:G5E9H0 intact:EBI-540096|uniprotkb:B2R600|uniprotkb:O43188|uniprotkb:B4DH15|intact:EBI-2557638|ensembl:ENSP00000310723 psi-mi:snut2_human(display_long)|uniprotkb:U4/U6.U5 tri-snRNP-associated 65 kDa protein(gene name synonym)|uniprotkb:Inactive ubiquitin-specific peptidase 39(gene name synonym)|uniprotkb:SAD1 homolog(gene name synonym)|uniprotkb:USP39(gene name)|psi-mi:USP39(display_short)|uniprotkb:CGI-21(orf name)|uniprotkb:HSPC332(orf name)|uniprotkb:PRO2855(orf name) psi-mi:ddx23_human(display_long)|uniprotkb:DEAD box protein 23(gene name synonym)|uniprotkb:100 kDa U5 snRNP-specific protein(gene name synonym)|uniprotkb:U5-100kD(gene name synonym)|uniprotkb:PRP28 homolog(gene name synonym)|uniprotkb:DDX23(gene name)|psi-mi:DDX23(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512555|imex:IM-12079-74 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006581.2|go:"GO:0008270"(zinc ion binding)|go:"GO:0008380"(RNA splicing)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0051301"(cell division)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR028889|interpro:IPR033809|interpro:IPR038765|go:"GO:0007049"(cell cycle)|rcsb pdb:3JCR|rcsb pdb:6AH0|rcsb pdb:6QW6|rcsb pdb:6QX9|reactome:R-HSA-72163|ensembl:ENSG00000168883(gene)|ensembl:ENST00000323701(transcript)|ensembl:ENST00000409470(transcript)|go:"GO:0000245"(spliceosomal complex assembly)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0006397"(mRNA processing)|refseq:NP_001243656.1|refseq:NP_001243657.1|refseq:NP_001243654.1|refseq:NP_001243655.1|refseq:XP_006711985.1|refseq:XP_006711986.1|refseq:XP_011530789.1|refseq:XP_011530790.1|refseq:XP_016858671.1 refseq:NP_004809.2|ensembl:ENSG00000174243(gene)|ensembl:ENST00000308025(transcript)|go:"GO:0000354"(cis assembly of pre-catalytic spliceosome)|go:"GO:0000375"(RNA splicing, via transesterification reactions)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000785"(chromatin)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005682"(U5 snRNP)|go:"GO:0005730"(nucleolus)|go:"GO:0008380"(RNA splicing)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0062176"(R-loop disassembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR000629(RNA helicase, ATP-dependent, DEAD-box, conserved site)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|mint:Q9BUQ8|rcsb pdb:3JCR|rcsb pdb:4NHO|rcsb pdb:6AH0|rcsb pdb:6QW6|rcsb pdb:6QX9|reactome:R-HSA-72163|reactome:R-HSA-72165|dip:DIP-34974N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:AMLhskNenuv+zqXSa7VesSbbVK89606 rogid:tEDp48akFaCjRBBXB4jtyrAsLQ89606 intact-crc:0C994AD12CFA96BF|rigid:dXIDFwKFnSyKylhQY+vEZ/Pj2E4 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q53GS9 uniprotkb:Q6P2Q9 intact:EBI-1044822|uniprotkb:Q6NX47|uniprotkb:Q96RK9|uniprotkb:Q9BV89|uniprotkb:Q9H381|uniprotkb:Q9P050|uniprotkb:Q9Y310|uniprotkb:A8K086|ensembl:ENSP00000312981|ensembl:ENSP00000386864|uniprotkb:D6W5L4|intact:EBI-2557627|uniprotkb:B4DHT4|uniprotkb:B3KM40|uniprotkb:G5E9H0 intact:EBI-538479|uniprotkb:O14547|uniprotkb:O75965|ensembl:ENSP00000304350|ensembl:ENSP00000460348|ensembl:ENSP00000479194|ensembl:ENSP00000488611 psi-mi:snut2_human(display_long)|uniprotkb:U4/U6.U5 tri-snRNP-associated 65 kDa protein(gene name synonym)|uniprotkb:Inactive ubiquitin-specific peptidase 39(gene name synonym)|uniprotkb:SAD1 homolog(gene name synonym)|uniprotkb:USP39(gene name)|psi-mi:USP39(display_short)|uniprotkb:CGI-21(orf name)|uniprotkb:HSPC332(orf name)|uniprotkb:PRO2855(orf name) psi-mi:prp8_human(display_long)|uniprotkb:Splicing factor Prp8(gene name synonym)|uniprotkb:PRP8 homolog(gene name synonym)|uniprotkb:220 kDa U5 snRNP-specific protein(gene name synonym)|uniprotkb:p220(gene name synonym)|uniprotkb:PRPC8(gene name synonym)|uniprotkb:PRPF8(gene name)|psi-mi:PRPF8(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512555|imex:IM-12079-74 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006581.2|go:"GO:0008270"(zinc ion binding)|go:"GO:0008380"(RNA splicing)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0051301"(cell division)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR028889|interpro:IPR033809|interpro:IPR038765|go:"GO:0007049"(cell cycle)|rcsb pdb:3JCR|rcsb pdb:6AH0|rcsb pdb:6QW6|rcsb pdb:6QX9|reactome:R-HSA-72163|ensembl:ENSG00000168883(gene)|ensembl:ENST00000323701(transcript)|ensembl:ENST00000409470(transcript)|go:"GO:0000245"(spliceosomal complex assembly)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0006397"(mRNA processing)|refseq:NP_001243656.1|refseq:NP_001243657.1|refseq:NP_001243654.1|refseq:NP_001243655.1|refseq:XP_006711985.1|refseq:XP_006711986.1|refseq:XP_011530789.1|refseq:XP_011530790.1|refseq:XP_016858671.1 refseq:NP_006436.3|ensembl:ENSG00000174231(gene)|ensembl:ENSG00000274442(gene)|ensembl:ENST00000304992(transcript)|ensembl:ENST00000572621(transcript)|ensembl:ENST00000614672(transcript)|ensembl:ENST00000634039(transcript)|go:"GO:0000244"(spliceosomal tri-snRNP complex assembly)|go:"GO:0000375"(RNA splicing, via transesterification reactions)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005682"(U5 snRNP)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0017070"(U6 snRNA binding)|go:"GO:0030619"(U1 snRNA binding)|go:"GO:0030620"(U2 snRNA binding)|go:"GO:0030623"(U5 snRNA binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0070122"(isopeptidase activity)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071006"(U2-type catalytic step 1 spliceosome)|go:"GO:0071007"(U2-type catalytic step 2 spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0097157"(pre-mRNA intronic binding)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR012591(PRO8NT)|interpro:IPR012592(PROCN)|interpro:IPR012984(PRO, C-terminal)|interpro:IPR019580|interpro:IPR019581|interpro:IPR019582|interpro:IPR021983|interpro:IPR027652|interpro:IPR037518|interpro:IPR042516|interpro:IPR043172|interpro:IPR043173|mint:Q6P2Q9|rcsb pdb:3E9L|rcsb pdb:3ENB|rcsb pdb:3JCR|rcsb pdb:3LRU|rcsb pdb:4JK7|rcsb pdb:4JK8|rcsb pdb:4JK9|rcsb pdb:4JKA|rcsb pdb:4JKB|rcsb pdb:4JKC|rcsb pdb:4JKD|rcsb pdb:4JKE|rcsb pdb:4JKF|rcsb pdb:4JKG|rcsb pdb:4JKH|rcsb pdb:4KIT|rcsb pdb:5MQF|rcsb pdb:5O9Z|rcsb pdb:5YZG|rcsb pdb:5Z56|rcsb pdb:5Z57|rcsb pdb:5Z58|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6FF4|rcsb pdb:6FF7|rcsb pdb:6ICZ|rcsb pdb:6ID0|rcsb pdb:6ID1|rcsb pdb:6QDV|rcsb pdb:6QW6|rcsb pdb:6QX9|rcsb pdb:6S8Q|rcsb pdb:6S9I|rcsb pdb:6ZYM|rcsb pdb:7A5P|rcsb pdb:7AAV|rcsb pdb:7ABF|rcsb pdb:7ABG|rcsb pdb:7ABI|rcsb pdb:7BDI|rcsb pdb:7BDJ|rcsb pdb:7BDK|rcsb pdb:7BDL|rcsb pdb:7DVQ|reactome:R-HSA-72163|reactome:R-HSA-72165|rcsb pdb:5XJC|dip:DIP-29614N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:AMLhskNenuv+zqXSa7VesSbbVK89606 rogid:I0ot8b3pvieXRI66omFm145sGVA9606 intact-crc:0C994AD12CFA96BF|rigid:dXIDFwKFnSyKylhQY+vEZ/Pj2E4 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q53GS9 uniprotkb:P04637 intact:EBI-1044822|uniprotkb:Q6NX47|uniprotkb:Q96RK9|uniprotkb:Q9BV89|uniprotkb:Q9H381|uniprotkb:Q9P050|uniprotkb:Q9Y310|uniprotkb:A8K086|ensembl:ENSP00000312981|ensembl:ENSP00000386864|uniprotkb:D6W5L4|intact:EBI-2557627|uniprotkb:B4DHT4|uniprotkb:B3KM40|uniprotkb:G5E9H0 intact:EBI-366083|uniprotkb:Q15086|uniprotkb:Q15087|uniprotkb:Q15088|uniprotkb:Q16535|uniprotkb:Q16807|uniprotkb:Q16808|uniprotkb:Q16809|uniprotkb:Q16810|uniprotkb:Q16811|uniprotkb:Q16848|uniprotkb:Q86UG1|uniprotkb:Q8J016|uniprotkb:Q99659|uniprotkb:Q9BTM4|uniprotkb:Q9HAQ8|uniprotkb:Q9NP68|uniprotkb:Q9NPJ2|uniprotkb:Q9NZD0|uniprotkb:Q9UBI2|uniprotkb:Q9UQ61|ensembl:ENSP00000269305|ensembl:ENSP00000391478|intact:EBI-28980681|uniprotkb:Q2XN98|uniprotkb:Q3LRW1|uniprotkb:Q3LRW2|uniprotkb:Q3LRW3|uniprotkb:Q3LRW4|uniprotkb:Q3LRW5 psi-mi:snut2_human(display_long)|uniprotkb:U4/U6.U5 tri-snRNP-associated 65 kDa protein(gene name synonym)|uniprotkb:Inactive ubiquitin-specific peptidase 39(gene name synonym)|uniprotkb:SAD1 homolog(gene name synonym)|uniprotkb:USP39(gene name)|psi-mi:USP39(display_short)|uniprotkb:CGI-21(orf name)|uniprotkb:HSPC332(orf name)|uniprotkb:PRO2855(orf name) psi-mi:p53_human(display_long)|uniprotkb:TP53(gene name)|psi-mi:TP53(display_short)|uniprotkb:P53(gene name synonym)|uniprotkb:Tumor suppressor p53(gene name synonym)|uniprotkb:Phosphoprotein p53(gene name synonym)|uniprotkb:Antigen NY-CO-13(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512555|imex:IM-12079-74 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006581.2|go:"GO:0008270"(zinc ion binding)|go:"GO:0008380"(RNA splicing)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0051301"(cell division)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR028889|interpro:IPR033809|interpro:IPR038765|go:"GO:0007049"(cell cycle)|rcsb pdb:3JCR|rcsb pdb:6AH0|rcsb pdb:6QW6|rcsb pdb:6QX9|reactome:R-HSA-72163|ensembl:ENSG00000168883(gene)|ensembl:ENST00000323701(transcript)|ensembl:ENST00000409470(transcript)|go:"GO:0000245"(spliceosomal complex assembly)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0006397"(mRNA processing)|refseq:NP_001243656.1|refseq:NP_001243657.1|refseq:NP_001243654.1|refseq:NP_001243655.1|refseq:XP_006711985.1|refseq:XP_006711986.1|refseq:XP_011530789.1|refseq:XP_011530790.1|refseq:XP_016858671.1 refseq:NP_001263624.1|refseq:NP_001263625.1|ensembl:ENSG00000141510(gene)|ensembl:ENST00000269305(transcript)|ensembl:ENST00000445888(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0001094"(TFIID-class transcription factor complex binding)|go:"GO:0001216"(DNA-binding transcription activator activity)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001756"(somitogenesis)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0002020"(protease binding)|go:"GO:0002039"(p53 binding)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002309"(T cell proliferation involved in immune response)|go:"GO:0002360"(T cell lineage commitment)|go:"GO:0002326"(B cell lineage commitment)|go:"GO:0031497"(chromatin assembly)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034103"(regulation of tissue remodeling)|go:"GO:0034613"(cellular protein localization)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035033"(histone deacetylase regulator activity)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035690"|go:"GO:0035794"(positive regulation of mitochondrial membrane permeability)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036003"(positive regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0036310"(ATP-dependent DNA/DNA annealing activity)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0002931"(response to ischemia)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006914"(autophagy)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006977"(DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)|go:"GO:0006978"(DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator)|go:"GO:0006983"(ER overload response)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007369"(gastrulation)|go:"GO:0007406"(negative regulation of neuroblast proliferation)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0043504"(mitochondrial DNA repair)|go:"GO:0043516"(regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0043621"(protein self-association)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045899"(positive regulation of RNA polymerase II transcription preinitiation complex assembly)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0048512"(circadian behavior)|go:"GO:0048539"(bone marrow development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051097"(negative regulation of helicase activity)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0062100"(positive regulation of programmed necrotic cell death)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0060411"(cardiac septum morphogenesis)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070245"(positive regulation of thymocyte apoptotic process)|go:"GO:0070266"(necroptotic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0071494"(cellular response to UV-C)|go:"GO:0072331"(signal transduction by p53 class mediator)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0072717"(cellular response to actinomycin D)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0090343"(positive regulation of cell aging)|go:"GO:0090399"(replicative senescence)|go:"GO:0090403"(oxidative stress-induced premature senescence)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0097252"(oligodendrocyte apoptotic process)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0140296"(general transcription initiation factor binding)|go:"GO:1900119"(positive regulation of execution phase of apoptosis)|go:"GO:1901525"(negative regulation of mitophagy)|go:"GO:1902108"(regulation of mitochondrial membrane permeability involved in apoptotic process)|go:"GO:1902253"(regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904024"(negative regulation of glucose catabolic process to lactate via pyruvate)|go:"GO:1905856"(negative regulation of pentose-phosphate shunt)|go:"GO:1990144"(intrinsic apoptotic signaling pathway in response to hypoxia)|go:"GO:1990248"(regulation of transcription from RNA polymerase II promoter in response to DNA damage)|go:"GO:1990440"(positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000269"(regulation of fibroblast apoptotic process)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000772"(regulation of cellular senescence)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002117(p53 tumor antigen)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR010991(p53, tetramerisation)|interpro:IPR011615(p53, DNA-binding)|go:"GO:0007569"(cell aging)|go:"GO:0008104"(protein localization)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008156"(negative regulation of DNA replication)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009299"(mRNA transcription)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009651"(response to salt stress)|go:"GO:0010165"(response to X-ray)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0016032"(viral process)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016605"(PML body)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031065"(positive regulation of histone deacetylation)|interpro:IPR012346(p53 and RUNT-type transcription factor, DNA-binding)|interpro:IPR013872("p53 transactivation domain (TAD)")|interpro:IPR036674|interpro:IPR040926|rcsb pdb:2ATA|rcsb pdb:2B3G|rcsb pdb:2BIM|rcsb pdb:2BIN|rcsb pdb:2BIO|rcsb pdb:2BIP|rcsb pdb:2AHI|rcsb pdb:2BIQ|rcsb pdb:2F1X|rcsb pdb:2FEJ|rcsb pdb:2FOJ|rcsb pdb:2FOO|rcsb pdb:2GS0|rcsb pdb:2H1L|rcsb pdb:2H2D|rcsb pdb:2H2F|rcsb pdb:2H4F|rcsb pdb:2H4H|rcsb pdb:2H4J|rcsb pdb:2H59|rcsb pdb:2J0Z|rcsb pdb:2J10|rcsb pdb:2J11|rcsb pdb:2J1W|rcsb pdb:2J1X|rcsb pdb:2J1Y|rcsb pdb:2J1Z|rcsb pdb:2J20|rcsb pdb:2J21|rcsb pdb:2K8F|rcsb pdb:2L14|rcsb pdb:2LY4|rcsb pdb:2MEJ|rcsb pdb:2MWO|rcsb pdb:2MWP|rcsb pdb:2MWY|rcsb pdb:2MZD|rcsb pdb:2OCJ|rcsb pdb:2PCX|rcsb pdb:1A1U|rcsb pdb:1AIE|rcsb pdb:1C26|rcsb pdb:1DT7|rcsb pdb:1GZH|rcsb pdb:1H26|rcsb pdb:1HS5|rcsb pdb:1JSP|rcsb pdb:1KZY|rcsb pdb:1MA3|rcsb pdb:1OLG|rcsb pdb:1OLH|rcsb pdb:1PES|rcsb pdb:1PET|mint:P04637|rcsb pdb:1SAE|rcsb pdb:1SAF|rcsb pdb:1SAK|rcsb pdb:1SAL|rcsb pdb:1TSR|rcsb pdb:1TUP|rcsb pdb:1UOL|rcsb pdb:1XQH|rcsb pdb:1YC5|rcsb pdb:1YCQ|rcsb pdb:1YCR|rcsb pdb:1YCS|rcsb pdb:2AC0|rcsb pdb:2ADY|refseq:NP_000537.3|refseq:NP_001119584.1|refseq:NP_001119585.1|refseq:NP_001119586.1|refseq:NP_001119587.1|refseq:NP_001119588.1|refseq:NP_001119589.1|rcsb pdb:2RUK|rcsb pdb:2VUK|rcsb pdb:3Q06|rcsb pdb:2WGX|rcsb pdb:2X0U|rcsb pdb:2X0V|rcsb pdb:2X0W|rcsb pdb:2XWR|rcsb pdb:2YBG|rcsb pdb:2YDR|rcsb pdb:2Z5S|rcsb pdb:2Z5T|rcsb pdb:3SAK|rcsb pdb:3D05|rcsb pdb:3D06|rcsb pdb:3D07|rcsb pdb:3D08|rcsb pdb:3D09|rcsb pdb:3D0A|rcsb pdb:3DAB|rcsb pdb:3DAC|rcsb pdb:3IGK|rcsb pdb:3IGL|rcsb pdb:3KMD|rcsb pdb:3TG5|rcsb pdb:3KZ8|rcsb pdb:3LW1|rcsb pdb:3OQ5|rcsb pdb:3PDH|rcsb pdb:3Q01|rcsb pdb:3Q05|rcsb pdb:3TS8|rcsb pdb:3ZME|rcsb pdb:4AGM|rcsb pdb:4AGN|rcsb pdb:4AGO|rcsb pdb:4AGP|rcsb pdb:4AGQ|rcsb pdb:4BUZ|rcsb pdb:4BV2|rcsb pdb:4HFZ|rcsb pdb:4HJE|rcsb pdb:4IBQ|rcsb pdb:4IBS|rcsb pdb:4IBT|rcsb pdb:4IBU|rcsb pdb:4IBV|rcsb pdb:4IBW|rcsb pdb:4IBY|rcsb pdb:4IBZ|rcsb pdb:4IJT|rcsb pdb:4KVP|rcsb pdb:4LO9|rcsb pdb:4LOE|rcsb pdb:4LOF|rcsb pdb:4MZI|rcsb pdb:4MZR|rcsb pdb:4QO1|rcsb pdb:4RP6|rcsb pdb:4RP7|rcsb pdb:4X34|rcsb pdb:4XR8|rcsb pdb:4ZZJ|rcsb pdb:5A7B|rcsb pdb:5AB9|rcsb pdb:5ABA|rcsb pdb:4AGL|rcsb pdb:5AOI|rcsb pdb:5AOJ|rcsb pdb:5AOK|rcsb pdb:5AOL|rcsb pdb:5AOM|rcsb pdb:6XRE|rcsb pdb:7BWN|rcsb pdb:7DHY|rcsb pdb:7DHZ|rcsb pdb:7EL4|reactome:R-HSA-111448|reactome:R-HSA-139915|reactome:R-HSA-1912408|reactome:R-HSA-2559580|reactome:R-HSA-2559584|reactome:R-HSA-2559585|reactome:R-HSA-2559586|reactome:R-HSA-3232118|reactome:R-HSA-349425|reactome:R-HSA-390471|reactome:R-HSA-5620971|reactome:R-HSA-5628897|reactome:R-HSA-5689880|reactome:R-HSA-5689896|reactome:R-HSA-5693565|reactome:R-HSA-6785807|reactome:R-HSA-6796648|reactome:R-HSA-6803204|reactome:R-HSA-6803205|reactome:R-HSA-6803207|reactome:R-HSA-6803211|reactome:R-HSA-6804114|reactome:R-HSA-6804115|reactome:R-HSA-6804116|reactome:R-HSA-6804754|reactome:R-HSA-6804756|reactome:R-HSA-6804757|reactome:R-HSA-6804758|reactome:R-HSA-6804759|reactome:R-HSA-6804760|reactome:R-HSA-6811555|reactome:R-HSA-69473|reactome:R-HSA-69481|reactome:R-HSA-69541|reactome:R-HSA-69895|reactome:R-HSA-8852276|reactome:R-HSA-8853884|reactome:R-HSA-8941855|reactome:R-HSA-8943724|reactome:R-HSA-983231|rcsb pdb:5ECG|rcsb pdb:5G4M|rcsb pdb:5G4N|rcsb pdb:5BUA|rcsb pdb:5G4O|rcsb pdb:5HOU|rcsb pdb:5HP0|rcsb pdb:5HPD|rcsb pdb:5LAP|rcsb pdb:5LGY|rcsb pdb:5MCT|rcsb pdb:5MCU|rcsb pdb:5MCV|rcsb pdb:5MCW|rcsb pdb:5MF7|rcsb pdb:5MG7|rcsb pdb:5MHC|rcsb pdb:5MOC|rcsb pdb:5O1A|rcsb pdb:5O1B|rcsb pdb:5O1C|rcsb pdb:5O1D|rcsb pdb:5O1E|rcsb pdb:5O1F|rcsb pdb:5O1G|rcsb pdb:5O1H|rcsb pdb:5O1I|rcsb pdb:5OL0|rcsb pdb:5UN8|rcsb pdb:5XZC|rcsb pdb:6FF9|rcsb pdb:6FJ5|rcsb pdb:6GGA|rcsb pdb:6GGB|rcsb pdb:6GGC|rcsb pdb:6GGD|rcsb pdb:6GGE|rcsb pdb:6GGF|rcsb pdb:6LHD|rcsb pdb:6R5L|rcsb pdb:6RJZ|rcsb pdb:6RK8|rcsb pdb:6RKI|rcsb pdb:6RKK|rcsb pdb:6RKM|rcsb pdb:6RL3|rcsb pdb:6RL4|rcsb pdb:6RL6|rcsb pdb:6RM5|rcsb pdb:6RM7|rcsb pdb:6RWH|rcsb pdb:6RWI|rcsb pdb:6RWS|rcsb pdb:6RWU|rcsb pdb:6RX2|rcsb pdb:6RZ3|rcsb pdb:6S39|rcsb pdb:6S40|rcsb pdb:6S9Q|rcsb pdb:6SHZ|rcsb pdb:6SI0|rcsb pdb:6SI1|rcsb pdb:6SI2|rcsb pdb:6SI3|rcsb pdb:6SI4|rcsb pdb:6SIN|rcsb pdb:6SIO|rcsb pdb:6SIP|rcsb pdb:6SIQ|rcsb pdb:6SL6|rcsb pdb:6SLV|rcsb pdb:6T58|rcsb pdb:6V4F|rcsb pdb:6V4H|rcsb pdb:6VQO|rcsb pdb:6VR1|rcsb pdb:6VR5|rcsb pdb:6VRM|rcsb pdb:6VRN|rcsb pdb:6W51|rcsb pdb:6S3C|ensembl:ENSP00000269305|ensembl:ENST00000420246|ensembl:ENSP00000391127|ensembl:ENSP00000391478|ensembl:ENST00000455263|ensembl:ENSP00000398846|ensembl:ENST00000504290|ensembl:ENSP00000484409|ensembl:ENST00000504937|ensembl:ENSP00000481179|ensembl:ENST00000510385|ensembl:ENSP00000478499|ensembl:ENST00000610292|ensembl:ENSP00000478219|ensembl:ENST00000610538|ensembl:ENSP00000480868|ensembl:ENST00000619485|ensembl:ENSP00000482537|ensembl:ENST00000620739|ensembl:ENSP00000481638|ensembl:ENST00000622645|ensembl:ENSP00000482222|refseq:NP_001119590.1|refseq:NP_001263626.1|refseq:NP_001263627.1|refseq:NP_001263628.1|refseq:NP_001263689.1|refseq:NP_001263690.1|dip:DIP-368N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:AMLhskNenuv+zqXSa7VesSbbVK89606 rogid:fGN3kSCGIpi/D6d/X5kaB0Xu8/k9606 intact-crc:0C994AD12CFA96BF|rigid:dXIDFwKFnSyKylhQY+vEZ/Pj2E4 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q53GS9 uniprotkb:Q15029 intact:EBI-1044822|uniprotkb:Q6NX47|uniprotkb:Q96RK9|uniprotkb:Q9BV89|uniprotkb:Q9H381|uniprotkb:Q9P050|uniprotkb:Q9Y310|uniprotkb:A8K086|ensembl:ENSP00000312981|ensembl:ENSP00000386864|uniprotkb:D6W5L4|intact:EBI-2557627|uniprotkb:B4DHT4|uniprotkb:B3KM40|uniprotkb:G5E9H0 intact:EBI-357897|uniprotkb:Q9BUR0|uniprotkb:D3DX58|uniprotkb:B4DK30|ensembl:ENSP00000392094|ensembl:ENSP00000467805|uniprotkb:B4DMC0|uniprotkb:K7EJ81 psi-mi:snut2_human(display_long)|uniprotkb:U4/U6.U5 tri-snRNP-associated 65 kDa protein(gene name synonym)|uniprotkb:Inactive ubiquitin-specific peptidase 39(gene name synonym)|uniprotkb:SAD1 homolog(gene name synonym)|uniprotkb:USP39(gene name)|psi-mi:USP39(display_short)|uniprotkb:CGI-21(orf name)|uniprotkb:HSPC332(orf name)|uniprotkb:PRO2855(orf name) psi-mi:u5s1_human(display_long)|uniprotkb:EFTUD2(gene name)|psi-mi:EFTUD2(display_short)|uniprotkb:KIAA0031(gene name synonym)|uniprotkb:SNRP116(gene name synonym)|uniprotkb:U5 snRNP-specific protein, 116 kDa(gene name synonym)|uniprotkb:Elongation factor Tu GTP-binding domain-containing protein 2(gene name synonym)|uniprotkb:SNU114 homolog(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512555|imex:IM-12079-74 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006581.2|go:"GO:0008270"(zinc ion binding)|go:"GO:0008380"(RNA splicing)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0051301"(cell division)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR028889|interpro:IPR033809|interpro:IPR038765|go:"GO:0007049"(cell cycle)|rcsb pdb:3JCR|rcsb pdb:6AH0|rcsb pdb:6QW6|rcsb pdb:6QX9|reactome:R-HSA-72163|ensembl:ENSG00000168883(gene)|ensembl:ENST00000323701(transcript)|ensembl:ENST00000409470(transcript)|go:"GO:0000245"(spliceosomal complex assembly)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0006397"(mRNA processing)|refseq:NP_001243656.1|refseq:NP_001243657.1|refseq:NP_001243654.1|refseq:NP_001243655.1|refseq:XP_006711985.1|refseq:XP_006711986.1|refseq:XP_011530789.1|refseq:XP_011530790.1|refseq:XP_016858671.1 refseq:NP_001136077.1|refseq:NP_004238.3|refseq:NP_001245282.1|go:"GO:0042220"(response to cocaine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071007"(U2-type catalytic step 2 spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000640(Translation elongation factor EFG/EF2, C-terminal)|interpro:IPR000795(Protein synthesis factor, GTP-binding)|interpro:IPR004161(Translation elongation factor EFTu/EF1A, domain 2)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR005517(Translation elongation factor EFG/EF2, domain IV)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR020568|interpro:IPR027417|interpro:IPR031950|interpro:IPR035647|interpro:IPR035655|interpro:IPR041095|interpro:IPR044121|mint:Q15029|rcsb pdb:3JCR|rcsb pdb:5MQF|rcsb pdb:5O9Z|rcsb pdb:5XJC|rcsb pdb:5YZG|rcsb pdb:5Z56|rcsb pdb:5Z57|rcsb pdb:5Z58|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6FF4|rcsb pdb:6FF7|rcsb pdb:6ICZ|rcsb pdb:6ID0|go:"GO:0035690"|rcsb pdb:6ID1|rcsb pdb:6QDV|rcsb pdb:6QW6|rcsb pdb:6QX9|rcsb pdb:6ZYM|rcsb pdb:7AAV|rcsb pdb:7ABF|rcsb pdb:7ABG|rcsb pdb:7ABI|rcsb pdb:7DVQ|reactome:R-HSA-72163|reactome:R-HSA-72165|ensembl:ENSG00000108883(gene)|ensembl:ENST00000426333(transcript)|ensembl:ENST00000591382(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0015030"(Cajal body)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0030623"(U5 snRNA binding)|refseq:NP_001245283.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:AMLhskNenuv+zqXSa7VesSbbVK89606 rogid:/dBQ7TFnGr31AYrb5e215eQ4vfc9606 intact-crc:0C994AD12CFA96BF|rigid:dXIDFwKFnSyKylhQY+vEZ/Pj2E4 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q53GS9 uniprotkb:O95218 intact:EBI-1044822|uniprotkb:Q6NX47|uniprotkb:Q96RK9|uniprotkb:Q9BV89|uniprotkb:Q9H381|uniprotkb:Q9P050|uniprotkb:Q9Y310|uniprotkb:A8K086|ensembl:ENSP00000312981|ensembl:ENSP00000386864|uniprotkb:D6W5L4|intact:EBI-2557627|uniprotkb:B4DHT4|uniprotkb:B3KM40|uniprotkb:G5E9H0 intact:EBI-1051583|intact:EBI-1642120|intact:EBI-1163882|intact:EBI-1166395|uniprotkb:Q53GS3|uniprotkb:Q59F92|uniprotkb:Q5VV33|uniprotkb:Q8IXN6|uniprotkb:Q9UP63|uniprotkb:Q5VV34|uniprotkb:D3DQ75|ensembl:ENSP00000359958 psi-mi:snut2_human(display_long)|uniprotkb:U4/U6.U5 tri-snRNP-associated 65 kDa protein(gene name synonym)|uniprotkb:Inactive ubiquitin-specific peptidase 39(gene name synonym)|uniprotkb:SAD1 homolog(gene name synonym)|uniprotkb:USP39(gene name)|psi-mi:USP39(display_short)|uniprotkb:CGI-21(orf name)|uniprotkb:HSPC332(orf name)|uniprotkb:PRO2855(orf name) psi-mi:zrab2_human(display_long)|uniprotkb:ZRANB2(gene name)|psi-mi:ZRANB2(display_short)|uniprotkb:ZIS(gene name synonym)|uniprotkb:ZNF265(gene name synonym)|uniprotkb:Zinc finger protein 265(gene name synonym)|uniprotkb:Zinc finger, splicing(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512555|imex:IM-12079-74 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006581.2|go:"GO:0008270"(zinc ion binding)|go:"GO:0008380"(RNA splicing)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0051301"(cell division)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR028889|interpro:IPR033809|interpro:IPR038765|go:"GO:0007049"(cell cycle)|rcsb pdb:3JCR|rcsb pdb:6AH0|rcsb pdb:6QW6|rcsb pdb:6QX9|reactome:R-HSA-72163|ensembl:ENSG00000168883(gene)|ensembl:ENST00000323701(transcript)|ensembl:ENST00000409470(transcript)|go:"GO:0000245"(spliceosomal complex assembly)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0006397"(mRNA processing)|refseq:NP_001243656.1|refseq:NP_001243657.1|refseq:NP_001243654.1|refseq:NP_001243655.1|refseq:XP_006711985.1|refseq:XP_006711986.1|refseq:XP_011530789.1|refseq:XP_011530790.1|refseq:XP_016858671.1 refseq:NP_005446.2|refseq:NP_976225.1|ensembl:ENSG00000132485(gene)|ensembl:ENST00000370920(transcript)|go:"GO:0001530"(lipopolysaccharide binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0046872"(metal ion binding)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR017337(Uncharacterised conserved protein UCP037956, zinc finger Ran-binding)|interpro:IPR036443|mint:O95218|rcsb pdb:1N0Z|rcsb pdb:2K1P|rcsb pdb:3G9Y psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:AMLhskNenuv+zqXSa7VesSbbVK89606 rogid:NSsZyRDwY5bF3I5OGvd1jGYTijY9606 intact-crc:0C994AD12CFA96BF|rigid:dXIDFwKFnSyKylhQY+vEZ/Pj2E4 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q53GS9 uniprotkb:Q9HC36 intact:EBI-1044822|uniprotkb:Q6NX47|uniprotkb:Q96RK9|uniprotkb:Q9BV89|uniprotkb:Q9H381|uniprotkb:Q9P050|uniprotkb:Q9Y310|uniprotkb:A8K086|ensembl:ENSP00000312981|ensembl:ENSP00000386864|uniprotkb:D6W5L4|intact:EBI-2557627|uniprotkb:B4DHT4|uniprotkb:B3KM40|uniprotkb:G5E9H0 intact:EBI-1045440|uniprotkb:Q9NVQ5|uniprotkb:Q53GN1|uniprotkb:Q86VC3|uniprotkb:Q96F76|ensembl:ENSP00000306080 psi-mi:snut2_human(display_long)|uniprotkb:U4/U6.U5 tri-snRNP-associated 65 kDa protein(gene name synonym)|uniprotkb:Inactive ubiquitin-specific peptidase 39(gene name synonym)|uniprotkb:SAD1 homolog(gene name synonym)|uniprotkb:USP39(gene name)|psi-mi:USP39(display_short)|uniprotkb:CGI-21(orf name)|uniprotkb:HSPC332(orf name)|uniprotkb:PRO2855(orf name) psi-mi:mrm3_human(display_long)|uniprotkb:MRM3(gene name)|psi-mi:MRM3(display_short)|uniprotkb:"16S rRNA (guanosine(1370)-2'-O)-methyltransferase"(gene name synonym)|uniprotkb:16S rRNA [Gm1370] 2'-O-methyltransferase(gene name synonym)|uniprotkb:RNA methyltransferase-like protein 1(gene name synonym)|uniprotkb:RNMTL1(gene name synonym)|uniprotkb:HC90(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512555|imex:IM-12079-74 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006581.2|go:"GO:0008270"(zinc ion binding)|go:"GO:0008380"(RNA splicing)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0051301"(cell division)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR028889|interpro:IPR033809|interpro:IPR038765|go:"GO:0007049"(cell cycle)|rcsb pdb:3JCR|rcsb pdb:6AH0|rcsb pdb:6QW6|rcsb pdb:6QX9|reactome:R-HSA-72163|ensembl:ENSG00000168883(gene)|ensembl:ENST00000323701(transcript)|ensembl:ENST00000409470(transcript)|go:"GO:0000245"(spliceosomal complex assembly)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0006397"(mRNA processing)|refseq:NP_001243656.1|refseq:NP_001243657.1|refseq:NP_001243654.1|refseq:NP_001243655.1|refseq:XP_006711985.1|refseq:XP_006711986.1|refseq:XP_011530789.1|refseq:XP_011530790.1|refseq:XP_016858671.1 refseq:NP_060616.1|refseq:NP_001304876.1|ensembl:ENSG00000171861(gene)|ensembl:ENST00000304478(transcript)|go:"GO:0000451"(rRNA 2'-O-methylation)|go:"GO:0003723"(RNA binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0042802"(identical protein binding)|go:"GO:0070039"("rRNA (guanosine-2'-O-)-methyltransferase activity")|interpro:IPR001537(tRNA/rRNA methyltransferase, SpoU)|interpro:IPR013123(RNA 2-O ribose methyltransferase, substrate binding)|interpro:IPR029028|interpro:IPR029064|mint:Q9HC36|reactome:R-HSA-6793080 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:AMLhskNenuv+zqXSa7VesSbbVK89606 rogid:oOaJQgUM9tpIOv6A20UkLtAQH9c9606 intact-crc:0C994AD12CFA96BF|rigid:dXIDFwKFnSyKylhQY+vEZ/Pj2E4 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q53GS9 uniprotkb:Q8WWY3 intact:EBI-1044822|uniprotkb:Q6NX47|uniprotkb:Q96RK9|uniprotkb:Q9BV89|uniprotkb:Q9H381|uniprotkb:Q9P050|uniprotkb:Q9Y310|uniprotkb:A8K086|ensembl:ENSP00000312981|ensembl:ENSP00000386864|uniprotkb:D6W5L4|intact:EBI-2557627|uniprotkb:B4DHT4|uniprotkb:B3KM40|uniprotkb:G5E9H0 intact:EBI-1567797|uniprotkb:Q8N7F9|uniprotkb:Q9H271|uniprotkb:Q9Y439|uniprotkb:Q17RB4|intact:EBI-10177194|uniprotkb:F1T0A5|uniprotkb:E7ESA8|uniprotkb:F1T0A4|ensembl:ENSP00000324122|ensembl:ENSP00000483929 psi-mi:snut2_human(display_long)|uniprotkb:U4/U6.U5 tri-snRNP-associated 65 kDa protein(gene name synonym)|uniprotkb:Inactive ubiquitin-specific peptidase 39(gene name synonym)|uniprotkb:SAD1 homolog(gene name synonym)|uniprotkb:USP39(gene name)|psi-mi:USP39(display_short)|uniprotkb:CGI-21(orf name)|uniprotkb:HSPC332(orf name)|uniprotkb:PRO2855(orf name) psi-mi:prp31_human(display_long)|uniprotkb:Pre-mRNA-processing factor 31(gene name synonym)|uniprotkb:U4/U6 snRNP 61 kDa protein(gene name synonym)|uniprotkb:Serologically defined breast cancer antigen NY-BR-99(gene name synonym)|uniprotkb:PRPF31(gene name)|psi-mi:PRPF31(display_short)|uniprotkb:PRP31(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512555|imex:IM-12079-74 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006581.2|go:"GO:0008270"(zinc ion binding)|go:"GO:0008380"(RNA splicing)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0051301"(cell division)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR028889|interpro:IPR033809|interpro:IPR038765|go:"GO:0007049"(cell cycle)|rcsb pdb:3JCR|rcsb pdb:6AH0|rcsb pdb:6QW6|rcsb pdb:6QX9|reactome:R-HSA-72163|ensembl:ENSG00000168883(gene)|ensembl:ENST00000323701(transcript)|ensembl:ENST00000409470(transcript)|go:"GO:0000245"(spliceosomal complex assembly)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0006397"(mRNA processing)|refseq:NP_001243656.1|refseq:NP_001243657.1|refseq:NP_001243654.1|refseq:NP_001243655.1|refseq:XP_006711985.1|refseq:XP_006711986.1|refseq:XP_011530789.1|refseq:XP_011530790.1|refseq:XP_016858671.1 refseq:XP_006723200.1|refseq:NP_056444.3|ensembl:ENSG00000105618(gene)|ensembl:ENSG00000275885(gene)|ensembl:ENST00000321030(transcript)|ensembl:ENST00000613693(transcript)|go:"GO:0000244"(spliceosomal tri-snRNP complex assembly)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005684"(U2-type spliceosomal complex)|go:"GO:0071339"(MLL1 complex)|go:"GO:0097526"(spliceosomal tri-snRNP complex)|go:"GO:0005687"(U4 snRNP)|go:"GO:0005690"(U4atac snRNP)|go:"GO:0015030"(Cajal body)|go:"GO:0016607"(nuclear speck)|interpro:IPR002687(Pre-mRNA processing ribonucleoprotein, binding region)|go:"GO:0030621"(U4 snRNA binding)|go:"GO:0030622"(U4atac snRNA binding)|go:"GO:0042802"(identical protein binding)|interpro:IPR012976(NOSIC)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0070990"(snRNP binding)|interpro:IPR019175|interpro:IPR027105|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071011"(precatalytic spliceosome)|go:"GO:0071166"(ribonucleoprotein complex localization)|interpro:IPR036070|interpro:IPR042239|mint:Q8WWY3|rcsb pdb:2OZB|rcsb pdb:3JCR|rcsb pdb:3SIU|rcsb pdb:3SIV|rcsb pdb:5O9Z|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6QW6|rcsb pdb:6QX9|reactome:R-HSA-72163 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:AMLhskNenuv+zqXSa7VesSbbVK89606 rogid:NsXY3tY7Y2EEK8rxoisqlfpzuf89606 intact-crc:0C994AD12CFA96BF|rigid:dXIDFwKFnSyKylhQY+vEZ/Pj2E4 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q53GS9 uniprotkb:Q969E8 intact:EBI-1044822|uniprotkb:Q6NX47|uniprotkb:Q96RK9|uniprotkb:Q9BV89|uniprotkb:Q9H381|uniprotkb:Q9P050|uniprotkb:Q9Y310|uniprotkb:A8K086|ensembl:ENSP00000312981|ensembl:ENSP00000386864|uniprotkb:D6W5L4|intact:EBI-2557627|uniprotkb:B4DHT4|uniprotkb:B3KM40|uniprotkb:G5E9H0 intact:EBI-746981|ensembl:ENSP00000364293 psi-mi:snut2_human(display_long)|uniprotkb:U4/U6.U5 tri-snRNP-associated 65 kDa protein(gene name synonym)|uniprotkb:Inactive ubiquitin-specific peptidase 39(gene name synonym)|uniprotkb:SAD1 homolog(gene name synonym)|uniprotkb:USP39(gene name)|psi-mi:USP39(display_short)|uniprotkb:CGI-21(orf name)|uniprotkb:HSPC332(orf name)|uniprotkb:PRO2855(orf name) psi-mi:tsr2_human(display_long)|uniprotkb:TSR2(gene name)|psi-mi:TSR2(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512555|imex:IM-12079-74 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006581.2|go:"GO:0008270"(zinc ion binding)|go:"GO:0008380"(RNA splicing)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0051301"(cell division)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR028889|interpro:IPR033809|interpro:IPR038765|go:"GO:0007049"(cell cycle)|rcsb pdb:3JCR|rcsb pdb:6AH0|rcsb pdb:6QW6|rcsb pdb:6QX9|reactome:R-HSA-72163|ensembl:ENSG00000168883(gene)|ensembl:ENST00000323701(transcript)|ensembl:ENST00000409470(transcript)|go:"GO:0000245"(spliceosomal complex assembly)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0006397"(mRNA processing)|refseq:NP_001243656.1|refseq:NP_001243657.1|refseq:NP_001243654.1|refseq:NP_001243655.1|refseq:XP_006711985.1|refseq:XP_006711986.1|refseq:XP_011530789.1|refseq:XP_011530790.1|refseq:XP_016858671.1 refseq:NP_477511.1|ensembl:ENSG00000158526(gene)|ensembl:ENST00000375151(transcript)|go:"GO:0000462"("maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|interpro:IPR019398 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:AMLhskNenuv+zqXSa7VesSbbVK89606 rogid:Pxy9Lzi0Jtk/725OCbYWo/2FyM49606 intact-crc:0C994AD12CFA96BF|rigid:dXIDFwKFnSyKylhQY+vEZ/Pj2E4 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q53GS9 uniprotkb:O75643 intact:EBI-1044822|uniprotkb:Q6NX47|uniprotkb:Q96RK9|uniprotkb:Q9BV89|uniprotkb:Q9H381|uniprotkb:Q9P050|uniprotkb:Q9Y310|uniprotkb:A8K086|ensembl:ENSP00000312981|ensembl:ENSP00000386864|uniprotkb:D6W5L4|intact:EBI-2557627|uniprotkb:B4DHT4|uniprotkb:B3KM40|uniprotkb:G5E9H0 intact:EBI-1045395|uniprotkb:O94884|uniprotkb:Q6PX59|uniprotkb:Q8NBE6|uniprotkb:Q96IF2|uniprotkb:Q9H7S0|uniprotkb:Q6NZY0|intact:EBI-1051631|ensembl:ENSP00000317123 psi-mi:snut2_human(display_long)|uniprotkb:U4/U6.U5 tri-snRNP-associated 65 kDa protein(gene name synonym)|uniprotkb:Inactive ubiquitin-specific peptidase 39(gene name synonym)|uniprotkb:SAD1 homolog(gene name synonym)|uniprotkb:USP39(gene name)|psi-mi:USP39(display_short)|uniprotkb:CGI-21(orf name)|uniprotkb:HSPC332(orf name)|uniprotkb:PRO2855(orf name) psi-mi:u520_human(display_long)|uniprotkb:SNRNP200(gene name)|psi-mi:SNRNP200(display_short)|uniprotkb:HELIC2(gene name synonym)|uniprotkb:KIAA0788(gene name synonym)|uniprotkb:U5 snRNP-specific 200 kDa protein(gene name synonym)|uniprotkb:Activating signal cointegrator 1 complex subunit 3-like 1(gene name synonym)|uniprotkb:BRR2 homolog(gene name synonym)|uniprotkb:ASCC3L1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512555|imex:IM-12079-74 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006581.2|go:"GO:0008270"(zinc ion binding)|go:"GO:0008380"(RNA splicing)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0051301"(cell division)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR028889|interpro:IPR033809|interpro:IPR038765|go:"GO:0007049"(cell cycle)|rcsb pdb:3JCR|rcsb pdb:6AH0|rcsb pdb:6QW6|rcsb pdb:6QX9|reactome:R-HSA-72163|ensembl:ENSG00000168883(gene)|ensembl:ENST00000323701(transcript)|ensembl:ENST00000409470(transcript)|go:"GO:0000245"(spliceosomal complex assembly)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0006397"(mRNA processing)|refseq:NP_001243656.1|refseq:NP_001243657.1|refseq:NP_001243654.1|refseq:NP_001243655.1|refseq:XP_006711985.1|refseq:XP_006711986.1|refseq:XP_011530789.1|refseq:XP_011530790.1|refseq:XP_016858671.1 refseq:NP_054733.2|ensembl:ENSG00000144028(gene)|ensembl:ENST00000323853(transcript)|go:"GO:0000354"(cis assembly of pre-catalytic spliceosome)|go:"GO:0000388"("spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)")|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005682"(U5 snRNP)|go:"GO:0016020"(membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071006"(U2-type catalytic step 1 spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR004179(Sec63)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR027417|interpro:IPR035892|interpro:IPR036388|interpro:IPR036390|interpro:IPR041094|mint:O75643|rcsb pdb:2Q0Z|rcsb pdb:3JCR|rcsb pdb:4F91|rcsb pdb:4F92|rcsb pdb:4F93|rcsb pdb:4KIT|rcsb pdb:5O9Z|rcsb pdb:5URJ|rcsb pdb:5URK|rcsb pdb:5URM|rcsb pdb:5XJC|rcsb pdb:5YZG|rcsb pdb:5Z56|rcsb pdb:5Z57|rcsb pdb:5Z58|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6FF7|rcsb pdb:6ICZ|rcsb pdb:6QDV|rcsb pdb:6QW6|rcsb pdb:6QX9|rcsb pdb:6S8O|rcsb pdb:6S8Q|rcsb pdb:6S9I|rcsb pdb:7A5P|rcsb pdb:7ABG|rcsb pdb:7ABI|rcsb pdb:7BDI|rcsb pdb:7BDJ|rcsb pdb:7BDK|rcsb pdb:7BDL|rcsb pdb:7DVQ|reactome:R-HSA-72163|reactome:R-HSA-72165|refseq:XP_016859092.1|dip:DIP-31659N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:AMLhskNenuv+zqXSa7VesSbbVK89606 rogid:2ZAcbMfMlk2xWWAiy7MeCL0CHtM9606 intact-crc:0C994AD12CFA96BF|rigid:dXIDFwKFnSyKylhQY+vEZ/Pj2E4 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q53GS9 uniprotkb:Q9NQ92 intact:EBI-1044822|uniprotkb:Q6NX47|uniprotkb:Q96RK9|uniprotkb:Q9BV89|uniprotkb:Q9H381|uniprotkb:Q9P050|uniprotkb:Q9Y310|uniprotkb:A8K086|ensembl:ENSP00000312981|ensembl:ENSP00000386864|uniprotkb:D6W5L4|intact:EBI-2557627|uniprotkb:B4DHT4|uniprotkb:B3KM40|uniprotkb:G5E9H0 intact:EBI-1642558|uniprotkb:E1P656|uniprotkb:A6NP14|uniprotkb:Q96EF5|uniprotkb:Q96P75|ensembl:ENSP00000304327 psi-mi:snut2_human(display_long)|uniprotkb:U4/U6.U5 tri-snRNP-associated 65 kDa protein(gene name synonym)|uniprotkb:Inactive ubiquitin-specific peptidase 39(gene name synonym)|uniprotkb:SAD1 homolog(gene name synonym)|uniprotkb:USP39(gene name)|psi-mi:USP39(display_short)|uniprotkb:CGI-21(orf name)|uniprotkb:HSPC332(orf name)|uniprotkb:PRO2855(orf name) psi-mi:coprs_human(display_long)|uniprotkb:COPRS(gene name)|psi-mi:COPRS(display_short)|uniprotkb:C17orf79(gene name synonym)|uniprotkb:COPR5(gene name synonym)|uniprotkb:Cooperator of PRMT5(gene name synonym)|uniprotkb:Protein TTP1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512555|imex:IM-12079-74 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006581.2|go:"GO:0008270"(zinc ion binding)|go:"GO:0008380"(RNA splicing)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0051301"(cell division)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR028889|interpro:IPR033809|interpro:IPR038765|go:"GO:0007049"(cell cycle)|rcsb pdb:3JCR|rcsb pdb:6AH0|rcsb pdb:6QW6|rcsb pdb:6QX9|reactome:R-HSA-72163|ensembl:ENSG00000168883(gene)|ensembl:ENST00000323701(transcript)|ensembl:ENST00000409470(transcript)|go:"GO:0000245"(spliceosomal complex assembly)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0006397"(mRNA processing)|refseq:NP_001243656.1|refseq:NP_001243657.1|refseq:NP_001243654.1|refseq:NP_001243655.1|refseq:XP_006711985.1|refseq:XP_006711986.1|refseq:XP_011530789.1|refseq:XP_011530790.1|refseq:XP_016858671.1 refseq:NP_060875.2|ensembl:ENSG00000172301(gene)|ensembl:ENST00000302362(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007517"(muscle organ development)|go:"GO:0042393"(histone binding)|go:"GO:0043985"(histone H4-R3 methylation)|interpro:IPR029289|mint:Q9NQ92|reactome:R-HSA-3214858 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:AMLhskNenuv+zqXSa7VesSbbVK89606 rogid:qO6jrJ2Zx0gVwqXbB+1EtiYvb589606 intact-crc:0C994AD12CFA96BF|rigid:dXIDFwKFnSyKylhQY+vEZ/Pj2E4 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q53GS9 uniprotkb:Q92620 intact:EBI-1044822|uniprotkb:Q6NX47|uniprotkb:Q96RK9|uniprotkb:Q9BV89|uniprotkb:Q9H381|uniprotkb:Q9P050|uniprotkb:Q9Y310|uniprotkb:A8K086|ensembl:ENSP00000312981|ensembl:ENSP00000386864|uniprotkb:D6W5L4|intact:EBI-2557627|uniprotkb:B4DHT4|uniprotkb:B3KM40|uniprotkb:G5E9H0 intact:EBI-1043041|uniprotkb:O75212|uniprotkb:Q96HN7|ensembl:ENSP00000268482|uniprotkb:D3DWS7|uniprotkb:B4DVG8 psi-mi:snut2_human(display_long)|uniprotkb:U4/U6.U5 tri-snRNP-associated 65 kDa protein(gene name synonym)|uniprotkb:Inactive ubiquitin-specific peptidase 39(gene name synonym)|uniprotkb:SAD1 homolog(gene name synonym)|uniprotkb:USP39(gene name)|psi-mi:USP39(display_short)|uniprotkb:CGI-21(orf name)|uniprotkb:HSPC332(orf name)|uniprotkb:PRO2855(orf name) psi-mi:prp16_human(display_long)|uniprotkb:DHX38(gene name)|psi-mi:DHX38(display_short)|uniprotkb:DDX38(gene name synonym)|uniprotkb:KIAA0224(gene name synonym)|uniprotkb:PRP16(gene name synonym)|uniprotkb:ATP-dependent RNA helicase DHX38(gene name synonym)|uniprotkb:DEAH box protein 38(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512555|imex:IM-12079-74 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006581.2|go:"GO:0008270"(zinc ion binding)|go:"GO:0008380"(RNA splicing)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0051301"(cell division)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR028889|interpro:IPR033809|interpro:IPR038765|go:"GO:0007049"(cell cycle)|rcsb pdb:3JCR|rcsb pdb:6AH0|rcsb pdb:6QW6|rcsb pdb:6QX9|reactome:R-HSA-72163|ensembl:ENSG00000168883(gene)|ensembl:ENST00000323701(transcript)|ensembl:ENST00000409470(transcript)|go:"GO:0000245"(spliceosomal complex assembly)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0006397"(mRNA processing)|refseq:NP_001243656.1|refseq:NP_001243657.1|refseq:NP_001243654.1|refseq:NP_001243655.1|refseq:XP_006711985.1|refseq:XP_006711986.1|refseq:XP_011530789.1|refseq:XP_011530790.1|refseq:XP_016858671.1 ensembl:ENSG00000140829(gene)|ensembl:ENST00000268482(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0016020"(membrane)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR002464(DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site)|interpro:IPR007502(Helicase-associated region)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR011709(Region of unknown function DUF1605)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR027417|mint:Q92620|rcsb pdb:5YZG|rcsb pdb:6ZYM|rcsb pdb:7A5P|reactome:R-HSA-159236|reactome:R-HSA-72163|reactome:R-HSA-72187|reactome:R-HSA-73856|refseq:NP_054722.2|refseq:XP_011521786.1|refseq:XP_011521787.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:AMLhskNenuv+zqXSa7VesSbbVK89606 rogid:miHZNGhDUIz9imwhlPz2tIsCNLs9606 intact-crc:0C994AD12CFA96BF|rigid:dXIDFwKFnSyKylhQY+vEZ/Pj2E4 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q53GS9 uniprotkb:O95777 intact:EBI-1044822|uniprotkb:Q6NX47|uniprotkb:Q96RK9|uniprotkb:Q9BV89|uniprotkb:Q9H381|uniprotkb:Q9P050|uniprotkb:Q9Y310|uniprotkb:A8K086|ensembl:ENSP00000312981|ensembl:ENSP00000386864|uniprotkb:D6W5L4|intact:EBI-2557627|uniprotkb:B4DHT4|uniprotkb:B3KM40|uniprotkb:G5E9H0 intact:EBI-347779|ensembl:ENSP00000249299 psi-mi:snut2_human(display_long)|uniprotkb:U4/U6.U5 tri-snRNP-associated 65 kDa protein(gene name synonym)|uniprotkb:Inactive ubiquitin-specific peptidase 39(gene name synonym)|uniprotkb:SAD1 homolog(gene name synonym)|uniprotkb:USP39(gene name)|psi-mi:USP39(display_short)|uniprotkb:CGI-21(orf name)|uniprotkb:HSPC332(orf name)|uniprotkb:PRO2855(orf name) psi-mi:lsm8_human(display_long)|uniprotkb:LSM8(gene name)|psi-mi:LSM8(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512555|imex:IM-12079-74 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006581.2|go:"GO:0008270"(zinc ion binding)|go:"GO:0008380"(RNA splicing)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0051301"(cell division)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR028889|interpro:IPR033809|interpro:IPR038765|go:"GO:0007049"(cell cycle)|rcsb pdb:3JCR|rcsb pdb:6AH0|rcsb pdb:6QW6|rcsb pdb:6QX9|reactome:R-HSA-72163|ensembl:ENSG00000168883(gene)|ensembl:ENST00000323701(transcript)|ensembl:ENST00000409470(transcript)|go:"GO:0000245"(spliceosomal complex assembly)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0006397"(mRNA processing)|refseq:NP_001243656.1|refseq:NP_001243657.1|refseq:NP_001243654.1|refseq:NP_001243655.1|refseq:XP_006711985.1|refseq:XP_006711986.1|refseq:XP_011530789.1|refseq:XP_011530790.1|refseq:XP_016858671.1 refseq:NP_057284.1|dip:DIP-31195N|ensembl:ENSG00000128534(gene)|ensembl:ENST00000249299(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005688"(U6 snRNP)|go:"GO:0016070"(RNA metabolic process)|go:"GO:0017070"(U6 snRNA binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071011"(precatalytic spliceosome)|go:"GO:0120115"(Lsm2-8 complex)|interpro:IPR001163(Like-Sm ribonucleoprotein, core)|interpro:IPR010920(Like-Sm ribonucleoprotein-related, core)|interpro:IPR034103|interpro:IPR044642|rcsb pdb:3JCR|rcsb pdb:5O9Z|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6QW6|rcsb pdb:6QX9|rcsb pdb:7ABG|reactome:R-HSA-72163 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:AMLhskNenuv+zqXSa7VesSbbVK89606 rogid:Kyf8IAEIkbe1s2NnqxqGA1o6BbU9606 intact-crc:0C994AD12CFA96BF|rigid:dXIDFwKFnSyKylhQY+vEZ/Pj2E4 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q53GS9 uniprotkb:O43395 intact:EBI-1044822|uniprotkb:Q6NX47|uniprotkb:Q96RK9|uniprotkb:Q9BV89|uniprotkb:Q9H381|uniprotkb:Q9P050|uniprotkb:Q9Y310|uniprotkb:A8K086|ensembl:ENSP00000312981|ensembl:ENSP00000386864|uniprotkb:D6W5L4|intact:EBI-2557627|uniprotkb:B4DHT4|uniprotkb:B3KM40|uniprotkb:G5E9H0 intact:EBI-744322|uniprotkb:O43446|uniprotkb:Q5VT54|uniprotkb:B4DSY9|intact:EBI-28983618|ensembl:ENSP00000315379 psi-mi:snut2_human(display_long)|uniprotkb:U4/U6.U5 tri-snRNP-associated 65 kDa protein(gene name synonym)|uniprotkb:Inactive ubiquitin-specific peptidase 39(gene name synonym)|uniprotkb:SAD1 homolog(gene name synonym)|uniprotkb:USP39(gene name)|psi-mi:USP39(display_short)|uniprotkb:CGI-21(orf name)|uniprotkb:HSPC332(orf name)|uniprotkb:PRO2855(orf name) psi-mi:prpf3_human(display_long)|uniprotkb:Pre-mRNA-splicing factor 3(gene name synonym)|uniprotkb:U4/U6 snRNP 90 kDa protein(gene name synonym)|uniprotkb:PRPF3(gene name)|psi-mi:PRPF3(display_short)|uniprotkb:HPRP3(gene name synonym)|uniprotkb:PRP3(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512555|imex:IM-12079-74 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006581.2|go:"GO:0008270"(zinc ion binding)|go:"GO:0008380"(RNA splicing)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0051301"(cell division)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR028889|interpro:IPR033809|interpro:IPR038765|go:"GO:0007049"(cell cycle)|rcsb pdb:3JCR|rcsb pdb:6AH0|rcsb pdb:6QW6|rcsb pdb:6QX9|reactome:R-HSA-72163|ensembl:ENSG00000168883(gene)|ensembl:ENST00000323701(transcript)|ensembl:ENST00000409470(transcript)|go:"GO:0000245"(spliceosomal complex assembly)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0006397"(mRNA processing)|refseq:NP_001243656.1|refseq:NP_001243657.1|refseq:NP_001243654.1|refseq:NP_001243655.1|refseq:XP_006711985.1|refseq:XP_006711986.1|refseq:XP_011530789.1|refseq:XP_011530790.1|refseq:XP_016858671.1 refseq:NP_004689.1|ensembl:ENSP00000315379|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005829"(cytosol)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0015030"(Cajal body)|go:"GO:0016607"(nuclear speck)|go:"GO:0042802"(identical protein binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0071005"(U2-type precatalytic spliceosome)|interpro:IPR002483(Splicing factor PWI)|interpro:IPR010541(Protein of unknown function DUF1115)|interpro:IPR013881(Pre-mRNA-splicing factor 3)|interpro:IPR027104|interpro:IPR036483|mint:O43395|rcsb pdb:1X4Q|rcsb pdb:3JCR|rcsb pdb:5O9Z|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6QW6|rcsb pdb:6QX9|reactome:R-HSA-72163|ensembl:ENSG00000117360(gene)|ensembl:ENST00000324862(transcript)|go:"GO:0000244"(spliceosomal tri-snRNP complex assembly)|go:"GO:0000375"(RNA splicing, via transesterification reactions)|dip:DIP-34508N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:AMLhskNenuv+zqXSa7VesSbbVK89606 rogid:Y2aO1gQjTU8JERVtrLpgbXq7nLU9606 intact-crc:0C994AD12CFA96BF|rigid:dXIDFwKFnSyKylhQY+vEZ/Pj2E4 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q53GS9 uniprotkb:P83876 intact:EBI-1044822|uniprotkb:Q6NX47|uniprotkb:Q96RK9|uniprotkb:Q9BV89|uniprotkb:Q9H381|uniprotkb:Q9P050|uniprotkb:Q9Y310|uniprotkb:A8K086|ensembl:ENSP00000312981|ensembl:ENSP00000386864|uniprotkb:D6W5L4|intact:EBI-2557627|uniprotkb:B4DHT4|uniprotkb:B3KM40|uniprotkb:G5E9H0 intact:EBI-746539|uniprotkb:O14834|uniprotkb:B2RC18|ensembl:ENSP00000269601 psi-mi:snut2_human(display_long)|uniprotkb:U4/U6.U5 tri-snRNP-associated 65 kDa protein(gene name synonym)|uniprotkb:Inactive ubiquitin-specific peptidase 39(gene name synonym)|uniprotkb:SAD1 homolog(gene name synonym)|uniprotkb:USP39(gene name)|psi-mi:USP39(display_short)|uniprotkb:CGI-21(orf name)|uniprotkb:HSPC332(orf name)|uniprotkb:PRO2855(orf name) psi-mi:txn4a_human(display_long)|uniprotkb:Thioredoxin-like U5 snRNP protein U5-15kD(gene name synonym)|uniprotkb:Spliceosomal U5 snRNP-specific 15 kDa protein(gene name synonym)|uniprotkb:DIM1 protein homolog(gene name synonym)|uniprotkb:TXNL4A(gene name)|psi-mi:TXNL4A(display_short)|uniprotkb:DIM1(gene name synonym)|uniprotkb:TXNL4(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512555|imex:IM-12079-74 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006581.2|go:"GO:0008270"(zinc ion binding)|go:"GO:0008380"(RNA splicing)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0051301"(cell division)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR028889|interpro:IPR033809|interpro:IPR038765|go:"GO:0007049"(cell cycle)|rcsb pdb:3JCR|rcsb pdb:6AH0|rcsb pdb:6QW6|rcsb pdb:6QX9|reactome:R-HSA-72163|ensembl:ENSG00000168883(gene)|ensembl:ENST00000323701(transcript)|ensembl:ENST00000409470(transcript)|go:"GO:0000245"(spliceosomal complex assembly)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0006397"(mRNA processing)|refseq:NP_001243656.1|refseq:NP_001243657.1|refseq:NP_001243654.1|refseq:NP_001243655.1|refseq:XP_006711985.1|refseq:XP_006711986.1|refseq:XP_011530789.1|refseq:XP_011530790.1|refseq:XP_016858671.1 refseq:NP_006692.1|refseq:NP_001290400.1|refseq:NP_001292486.1|refseq:NP_001292492.1|refseq:NP_001292493.1|ensembl:ENSG00000141759(gene)|ensembl:ENST00000269601(transcript)|go:"GO:0000245"(spliceosomal complex assembly)|go:"GO:0000375"(RNA splicing, via transesterification reactions)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005829"(cytosol)|go:"GO:0007049"(cell cycle)|go:"GO:0031965"(nuclear membrane)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0051301"(cell division)|go:"GO:0071005"(U2-type precatalytic spliceosome)|interpro:IPR004123(mRNA splicing factor, thioredoxin-like U5 snRNP)|interpro:IPR036249|rcsb pdb:1PQN|rcsb pdb:1QGV|rcsb pdb:1SYX|rcsb pdb:3JCR|rcsb pdb:4BWQ|rcsb pdb:4BWS|rcsb pdb:4CDO|rcsb pdb:5O9Z|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6QW6|rcsb pdb:6QX9|reactome:R-HSA-72163|reactome:R-HSA-72165|go:"GO:0005682"(U5 snRNP) psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:AMLhskNenuv+zqXSa7VesSbbVK89606 rogid:gGYj9Meks26JpYxw6wB5S2vIrkE9606 intact-crc:0C994AD12CFA96BF|rigid:dXIDFwKFnSyKylhQY+vEZ/Pj2E4 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q53GS9 uniprotkb:Q13523 intact:EBI-1044822|uniprotkb:Q6NX47|uniprotkb:Q96RK9|uniprotkb:Q9BV89|uniprotkb:Q9H381|uniprotkb:Q9P050|uniprotkb:Q9Y310|uniprotkb:A8K086|ensembl:ENSP00000312981|ensembl:ENSP00000386864|uniprotkb:D6W5L4|intact:EBI-2557627|uniprotkb:B4DHT4|uniprotkb:B3KM40|uniprotkb:G5E9H0 intact:EBI-395940|uniprotkb:Q8TDP2|uniprotkb:Q96QT7|uniprotkb:Q9UEE6|uniprotkb:Q5TAY8|uniprotkb:A8K5C9|uniprotkb:Q5D0F6|uniprotkb:Q8IVC3|intact:EBI-1058380|ensembl:ENSP00000337194|ensembl:ENSP00000433547 psi-mi:snut2_human(display_long)|uniprotkb:U4/U6.U5 tri-snRNP-associated 65 kDa protein(gene name synonym)|uniprotkb:Inactive ubiquitin-specific peptidase 39(gene name synonym)|uniprotkb:SAD1 homolog(gene name synonym)|uniprotkb:USP39(gene name)|psi-mi:USP39(display_short)|uniprotkb:CGI-21(orf name)|uniprotkb:HSPC332(orf name)|uniprotkb:PRO2855(orf name) psi-mi:prp4b_human(display_long)|uniprotkb:PRPF4B(gene name)|psi-mi:PRPF4B(display_short)|uniprotkb:KIAA0536(gene name synonym)|uniprotkb:PRP4(gene name synonym)|uniprotkb:PRP4H(gene name synonym)|uniprotkb:PRP4K(gene name synonym)|uniprotkb:PRP4 pre-mRNA-processing factor 4 homolog(gene name synonym)|uniprotkb:PRP4 kinase(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512555|imex:IM-12079-74 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006581.2|go:"GO:0008270"(zinc ion binding)|go:"GO:0008380"(RNA splicing)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0051301"(cell division)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR028889|interpro:IPR033809|interpro:IPR038765|go:"GO:0007049"(cell cycle)|rcsb pdb:3JCR|rcsb pdb:6AH0|rcsb pdb:6QW6|rcsb pdb:6QX9|reactome:R-HSA-72163|ensembl:ENSG00000168883(gene)|ensembl:ENST00000323701(transcript)|ensembl:ENST00000409470(transcript)|go:"GO:0000245"(spliceosomal complex assembly)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0006397"(mRNA processing)|refseq:NP_001243656.1|refseq:NP_001243657.1|refseq:NP_001243654.1|refseq:NP_001243655.1|refseq:XP_006711985.1|refseq:XP_006711986.1|refseq:XP_011530789.1|refseq:XP_011530790.1|refseq:XP_016858671.1 refseq:NP_003904.3|ensembl:ENSG00000112739(gene)|ensembl:ENST00000337659(transcript)|ensembl:ENST00000480058(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008380"(RNA splicing)|go:"GO:0016607"(nuclear speck)|go:"GO:0045292"(mRNA cis splicing, via spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR044092|mint:Q13523|rcsb pdb:4IAN|rcsb pdb:4IFC|rcsb pdb:4IIR|rcsb pdb:4IJP|rcsb pdb:6CNH|rcsb pdb:6PJJ|rcsb pdb:6PK6|rcsb pdb:6QX9|refseq:XP_016866899.1|refseq:XP_016866900.1|refseq:XP_016866901.1|refseq:XP_016866902.1|refseq:XP_016866903.1|refseq:XP_016866904.1|refseq:XP_016866905.1|refseq:XP_016866906.1|refseq:XP_016866907.1|refseq:XP_016866908.1|refseq:XP_016866909.1|refseq:XP_016866910.1|refseq:XP_016866911.1|refseq:XP_016866912.1|refseq:XP_016866913.1|refseq:XP_016866914.1|refseq:XP_016866915.1|refseq:XP_016866916.1|refseq:XP_016866917.1|refseq:XP_016866918.1|refseq:XP_016866919.1|refseq:XP_016866920.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:AMLhskNenuv+zqXSa7VesSbbVK89606 rogid:ZklPbRvRbbVRJYqV3JkS2jG3EIc9606 intact-crc:0C994AD12CFA96BF|rigid:dXIDFwKFnSyKylhQY+vEZ/Pj2E4 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q53GS9 uniprotkb:Q6P5R6 intact:EBI-1044822|uniprotkb:Q6NX47|uniprotkb:Q96RK9|uniprotkb:Q9BV89|uniprotkb:Q9H381|uniprotkb:Q9P050|uniprotkb:Q9Y310|uniprotkb:A8K086|ensembl:ENSP00000312981|ensembl:ENSP00000386864|uniprotkb:D6W5L4|intact:EBI-2557627|uniprotkb:B4DHT4|uniprotkb:B3KM40|uniprotkb:G5E9H0 intact:EBI-2512545|ensembl:ENSP00000346080|uniprotkb:Q32Q77 psi-mi:snut2_human(display_long)|uniprotkb:U4/U6.U5 tri-snRNP-associated 65 kDa protein(gene name synonym)|uniprotkb:Inactive ubiquitin-specific peptidase 39(gene name synonym)|uniprotkb:SAD1 homolog(gene name synonym)|uniprotkb:USP39(gene name)|psi-mi:USP39(display_short)|uniprotkb:CGI-21(orf name)|uniprotkb:HSPC332(orf name)|uniprotkb:PRO2855(orf name) psi-mi:rl22l_human(display_long)|uniprotkb:RPL22L1(gene name)|psi-mi:RPL22L1(display_short)|uniprotkb:Large ribosomal subunit protein eL22-like 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512555|imex:IM-12079-74 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006581.2|go:"GO:0008270"(zinc ion binding)|go:"GO:0008380"(RNA splicing)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0051301"(cell division)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR028889|interpro:IPR033809|interpro:IPR038765|go:"GO:0007049"(cell cycle)|rcsb pdb:3JCR|rcsb pdb:6AH0|rcsb pdb:6QW6|rcsb pdb:6QX9|reactome:R-HSA-72163|ensembl:ENSG00000168883(gene)|ensembl:ENST00000323701(transcript)|ensembl:ENST00000409470(transcript)|go:"GO:0000245"(spliceosomal complex assembly)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0006397"(mRNA processing)|refseq:NP_001243656.1|refseq:NP_001243657.1|refseq:NP_001243654.1|refseq:NP_001243655.1|refseq:XP_006711985.1|refseq:XP_006711986.1|refseq:XP_011530789.1|refseq:XP_011530790.1|refseq:XP_016858671.1 ensembl:ENSG00000163584(gene)|ensembl:ENST00000295830(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005840"(ribosome)|interpro:IPR002671(Ribosomal protein L22e)|interpro:IPR028370|interpro:IPR038526|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|refseq:NP_001093115.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:AMLhskNenuv+zqXSa7VesSbbVK89606 rogid:F0hKX3isBeCP4gGQNBrar7f5YUw9606 intact-crc:0C994AD12CFA96BF|rigid:dXIDFwKFnSyKylhQY+vEZ/Pj2E4 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q53GS9 uniprotkb:Q8WVK2 intact:EBI-1044822|uniprotkb:Q6NX47|uniprotkb:Q96RK9|uniprotkb:Q9BV89|uniprotkb:Q9H381|uniprotkb:Q9P050|uniprotkb:Q9Y310|uniprotkb:A8K086|ensembl:ENSP00000312981|ensembl:ENSP00000386864|uniprotkb:D6W5L4|intact:EBI-2557627|uniprotkb:B4DHT4|uniprotkb:B3KM40|uniprotkb:G5E9H0 intact:EBI-2512550|ensembl:ENSP00000244227|ensembl:ENSP00000395144|uniprotkb:Q15410|intact:EBI-2557655 psi-mi:snut2_human(display_long)|uniprotkb:U4/U6.U5 tri-snRNP-associated 65 kDa protein(gene name synonym)|uniprotkb:Inactive ubiquitin-specific peptidase 39(gene name synonym)|uniprotkb:SAD1 homolog(gene name synonym)|uniprotkb:USP39(gene name)|psi-mi:USP39(display_short)|uniprotkb:CGI-21(orf name)|uniprotkb:HSPC332(orf name)|uniprotkb:PRO2855(orf name) psi-mi:snr27_human(display_long)|uniprotkb:SNRNP27(gene name)|psi-mi:SNRNP27(display_short)|uniprotkb:U4/U6.U5 tri-snRNP-associated protein 3(gene name synonym)|uniprotkb:U4/U6.U5 tri-snRNP-associated 27 kDa protein(gene name synonym)|uniprotkb:Nucleic acid-binding protein RY-1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512555|imex:IM-12079-74 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006581.2|go:"GO:0008270"(zinc ion binding)|go:"GO:0008380"(RNA splicing)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0051301"(cell division)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR028889|interpro:IPR033809|interpro:IPR038765|go:"GO:0007049"(cell cycle)|rcsb pdb:3JCR|rcsb pdb:6AH0|rcsb pdb:6QW6|rcsb pdb:6QX9|reactome:R-HSA-72163|ensembl:ENSG00000168883(gene)|ensembl:ENST00000323701(transcript)|ensembl:ENST00000409470(transcript)|go:"GO:0000245"(spliceosomal complex assembly)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0006397"(mRNA processing)|refseq:NP_001243656.1|refseq:NP_001243657.1|refseq:NP_001243654.1|refseq:NP_001243655.1|refseq:XP_006711985.1|refseq:XP_006711986.1|refseq:XP_011530789.1|refseq:XP_011530790.1|refseq:XP_016858671.1 ensembl:ENSG00000124380(gene)|ensembl:ENST00000244227(transcript)|ensembl:ENST00000450162(transcript)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|interpro:IPR013957(Protein of unknown function DUF1777)|rcsb pdb:6QW6|rcsb pdb:6QX9|reactome:R-HSA-72163|refseq:NP_006848.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:AMLhskNenuv+zqXSa7VesSbbVK89606 rogid:wSOfld20fuDA9ZN9vDXLilFmmSs9606 intact-crc:0C994AD12CFA96BF|rigid:dXIDFwKFnSyKylhQY+vEZ/Pj2E4 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q53GS9 uniprotkb:Q9Y654 intact:EBI-1044822|uniprotkb:Q6NX47|uniprotkb:Q96RK9|uniprotkb:Q9BV89|uniprotkb:Q9H381|uniprotkb:Q9P050|uniprotkb:Q9Y310|uniprotkb:A8K086|ensembl:ENSP00000312981|ensembl:ENSP00000386864|uniprotkb:D6W5L4|intact:EBI-2557627|uniprotkb:B4DHT4|uniprotkb:B3KM40|uniprotkb:G5E9H0 intact:EBI-2512557 psi-mi:snut2_human(display_long)|uniprotkb:U4/U6.U5 tri-snRNP-associated 65 kDa protein(gene name synonym)|uniprotkb:Inactive ubiquitin-specific peptidase 39(gene name synonym)|uniprotkb:SAD1 homolog(gene name synonym)|uniprotkb:USP39(gene name)|psi-mi:USP39(display_short)|uniprotkb:CGI-21(orf name)|uniprotkb:HSPC332(orf name)|uniprotkb:PRO2855(orf name) psi-mi:q9y654_human(display_long)|uniprotkb:CBX1(gene name)|psi-mi:CBX1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512555|imex:IM-12079-74 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006581.2|go:"GO:0008270"(zinc ion binding)|go:"GO:0008380"(RNA splicing)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0051301"(cell division)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR028889|interpro:IPR033809|interpro:IPR038765|go:"GO:0007049"(cell cycle)|rcsb pdb:3JCR|rcsb pdb:6AH0|rcsb pdb:6QW6|rcsb pdb:6QX9|reactome:R-HSA-72163|ensembl:ENSG00000168883(gene)|ensembl:ENST00000323701(transcript)|ensembl:ENST00000409470(transcript)|go:"GO:0000245"(spliceosomal complex assembly)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0006397"(mRNA processing)|refseq:NP_001243656.1|refseq:NP_001243657.1|refseq:NP_001243654.1|refseq:NP_001243655.1|refseq:XP_006711985.1|refseq:XP_006711986.1|refseq:XP_011530789.1|refseq:XP_011530790.1|refseq:XP_016858671.1 go:"GO:0005634"(nucleus)|interpro:IPR023780|interpro:IPR000953(Chromo domain)|interpro:IPR008251(Chromo shadow)|interpro:IPR016197(Chromo domain-like)|interpro:IPR023779 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:AMLhskNenuv+zqXSa7VesSbbVK89606 rogid:VIzvwFCqGJgaYE0MGOjYcJ1d7Cc9606 intact-crc:0C994AD12CFA96BF|rigid:dXIDFwKFnSyKylhQY+vEZ/Pj2E4 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q53GS9 uniprotkb:Q9NY12 intact:EBI-1044822|uniprotkb:Q6NX47|uniprotkb:Q96RK9|uniprotkb:Q9BV89|uniprotkb:Q9H381|uniprotkb:Q9P050|uniprotkb:Q9Y310|uniprotkb:A8K086|ensembl:ENSP00000312981|ensembl:ENSP00000386864|uniprotkb:D6W5L4|intact:EBI-2557627|uniprotkb:B4DHT4|uniprotkb:B3KM40|uniprotkb:G5E9H0 intact:EBI-2510382|ensembl:ENSP00000226796|ensembl:ENSP00000378127|uniprotkb:Q5MJQ2 psi-mi:snut2_human(display_long)|uniprotkb:U4/U6.U5 tri-snRNP-associated 65 kDa protein(gene name synonym)|uniprotkb:Inactive ubiquitin-specific peptidase 39(gene name synonym)|uniprotkb:SAD1 homolog(gene name synonym)|uniprotkb:USP39(gene name)|psi-mi:USP39(display_short)|uniprotkb:CGI-21(orf name)|uniprotkb:HSPC332(orf name)|uniprotkb:PRO2855(orf name) psi-mi:gar1_human(display_long)|uniprotkb:GAR1(gene name)|psi-mi:GAR1(display_short)|uniprotkb:NOLA1(gene name synonym)|uniprotkb:snoRNP protein GAR1(gene name synonym)|uniprotkb:Nucleolar protein family A member 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512555|imex:IM-12079-74 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006581.2|go:"GO:0008270"(zinc ion binding)|go:"GO:0008380"(RNA splicing)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0051301"(cell division)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR028889|interpro:IPR033809|interpro:IPR038765|go:"GO:0007049"(cell cycle)|rcsb pdb:3JCR|rcsb pdb:6AH0|rcsb pdb:6QW6|rcsb pdb:6QX9|reactome:R-HSA-72163|ensembl:ENSG00000168883(gene)|ensembl:ENST00000323701(transcript)|ensembl:ENST00000409470(transcript)|go:"GO:0000245"(spliceosomal complex assembly)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0006397"(mRNA processing)|refseq:NP_001243656.1|refseq:NP_001243657.1|refseq:NP_001243654.1|refseq:NP_001243655.1|refseq:XP_006711985.1|refseq:XP_006711986.1|refseq:XP_011530789.1|refseq:XP_011530790.1|refseq:XP_016858671.1 ensembl:ENSG00000109534(gene)|ensembl:ENST00000226796(transcript)|ensembl:ENST00000394631(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0031429"(box H/ACA snoRNP complex)|go:"GO:0034513"(box H/ACA snoRNA binding)|go:"GO:0070034"(telomerase RNA binding)|go:"GO:0072589"(box H/ACA scaRNP complex)|go:"GO:0090661"(box H/ACA telomerase RNP complex)|interpro:IPR007504(Gar1 protein RNA-binding region)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)|interpro:IPR038664|mint:Q9NY12|rcsb pdb:7BGB|reactome:R-HSA-171319|go:"GO:0000454"(snoRNA guided rRNA pseudouridine synthesis)|reactome:R-HSA-6790901|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|refseq:NP_061856.1|refseq:NP_127460.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:AMLhskNenuv+zqXSa7VesSbbVK89606 rogid:voLJvYfWyMWtTf0VSd7XeY3psC09606 intact-crc:0C994AD12CFA96BF|rigid:dXIDFwKFnSyKylhQY+vEZ/Pj2E4 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q53GS9 uniprotkb:O43290 intact:EBI-1044822|uniprotkb:Q6NX47|uniprotkb:Q96RK9|uniprotkb:Q9BV89|uniprotkb:Q9H381|uniprotkb:Q9P050|uniprotkb:Q9Y310|uniprotkb:A8K086|ensembl:ENSP00000312981|ensembl:ENSP00000386864|uniprotkb:D6W5L4|intact:EBI-2557627|uniprotkb:B4DHT4|uniprotkb:B3KM40|uniprotkb:G5E9H0 intact:EBI-607761|ensembl:ENSP00000310448|uniprotkb:A6NDN1|uniprotkb:Q53GB5 psi-mi:snut2_human(display_long)|uniprotkb:U4/U6.U5 tri-snRNP-associated 65 kDa protein(gene name synonym)|uniprotkb:Inactive ubiquitin-specific peptidase 39(gene name synonym)|uniprotkb:SAD1 homolog(gene name synonym)|uniprotkb:USP39(gene name)|psi-mi:USP39(display_short)|uniprotkb:CGI-21(orf name)|uniprotkb:HSPC332(orf name)|uniprotkb:PRO2855(orf name) psi-mi:snut1_human(display_long)|uniprotkb:U4/U6.U5 tri-snRNP-associated 110 kDa protein(gene name synonym)|uniprotkb:SART1(gene name)|psi-mi:SART1(display_short)|uniprotkb:SNU66 homolog(gene name synonym)|uniprotkb:Squamous cell carcinoma antigen recognized by T-cells 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512555|imex:IM-12079-74 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006581.2|go:"GO:0008270"(zinc ion binding)|go:"GO:0008380"(RNA splicing)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0051301"(cell division)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR028889|interpro:IPR033809|interpro:IPR038765|go:"GO:0007049"(cell cycle)|rcsb pdb:3JCR|rcsb pdb:6AH0|rcsb pdb:6QW6|rcsb pdb:6QX9|reactome:R-HSA-72163|ensembl:ENSG00000168883(gene)|ensembl:ENST00000323701(transcript)|ensembl:ENST00000409470(transcript)|go:"GO:0000245"(spliceosomal complex assembly)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0006397"(mRNA processing)|refseq:NP_001243656.1|refseq:NP_001243657.1|refseq:NP_001243654.1|refseq:NP_001243655.1|refseq:XP_006711985.1|refseq:XP_006711986.1|refseq:XP_011530789.1|refseq:XP_011530790.1|refseq:XP_016858671.1 ensembl:ENSG00000175467(gene)|ensembl:ENST00000312397(transcript)|go:"GO:0000387"(spliceosomal snRNP assembly)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000481"(maturation of 5S rRNA)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0015030"(Cajal body)|go:"GO:0016607"(nuclear speck)|go:"GO:0045292"(mRNA cis splicing, via spliceosome)|go:"GO:0045585"(positive regulation of cytotoxic T cell differentiation)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|interpro:IPR005011(SART-1 protein)|mint:O43290|rcsb pdb:4PYU|rcsb pdb:5O9Z|rcsb pdb:6AHD|rcsb pdb:6QW6|rcsb pdb:6QX9|reactome:R-HSA-72163|refseq:NP_005137.1|dip:DIP-33360N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:AMLhskNenuv+zqXSa7VesSbbVK89606 rogid:egvWHy7UXW+MkGtGEW984yvRU9k9606 intact-crc:0C994AD12CFA96BF|rigid:dXIDFwKFnSyKylhQY+vEZ/Pj2E4 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q53GS9 uniprotkb:Q7L0Y3 intact:EBI-1044822|uniprotkb:Q6NX47|uniprotkb:Q96RK9|uniprotkb:Q9BV89|uniprotkb:Q9H381|uniprotkb:Q9P050|uniprotkb:Q9Y310|uniprotkb:A8K086|ensembl:ENSP00000312981|ensembl:ENSP00000386864|uniprotkb:D6W5L4|intact:EBI-2557627|uniprotkb:B4DHT4|uniprotkb:B3KM40|uniprotkb:G5E9H0 intact:EBI-2107046|uniprotkb:Q9NRG5|uniprotkb:Q9NX54|uniprotkb:Q9Y596|ensembl:ENSP00000312356 psi-mi:snut2_human(display_long)|uniprotkb:U4/U6.U5 tri-snRNP-associated 65 kDa protein(gene name synonym)|uniprotkb:Inactive ubiquitin-specific peptidase 39(gene name synonym)|uniprotkb:SAD1 homolog(gene name synonym)|uniprotkb:USP39(gene name)|psi-mi:USP39(display_short)|uniprotkb:CGI-21(orf name)|uniprotkb:HSPC332(orf name)|uniprotkb:PRO2855(orf name) psi-mi:tm10c_human(display_long)|uniprotkb:TRMT10C(gene name)|psi-mi:TRMT10C(display_short)|uniprotkb:HBV pre-S2 trans-regulated protein 2(gene name synonym)|uniprotkb:MRPP1(gene name synonym)|uniprotkb:RG9MTD1(gene name synonym)|uniprotkb:"RNA (guanine-9-)-methyltransferase domain-containing protein 1"(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-49(gene name synonym)|uniprotkb:Mitochondrial ribonuclease P protein 1(gene name synonym)|uniprotkb:"mRNA methyladenosine-N(1)-methyltransferase"(gene name synonym)|uniprotkb:"tRNA (adenine(9)-N(1))-methyltransferase"(gene name synonym)|uniprotkb:"tRNA (guanine(9)-N(1))-methyltransferase"(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512555|imex:IM-12079-74 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006581.2|go:"GO:0008270"(zinc ion binding)|go:"GO:0008380"(RNA splicing)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0051301"(cell division)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR028889|interpro:IPR033809|interpro:IPR038765|go:"GO:0007049"(cell cycle)|rcsb pdb:3JCR|rcsb pdb:6AH0|rcsb pdb:6QW6|rcsb pdb:6QX9|reactome:R-HSA-72163|ensembl:ENSG00000168883(gene)|ensembl:ENST00000323701(transcript)|ensembl:ENST00000409470(transcript)|go:"GO:0000245"(spliceosomal complex assembly)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0006397"(mRNA processing)|refseq:NP_001243656.1|refseq:NP_001243657.1|refseq:NP_001243654.1|refseq:NP_001243655.1|refseq:XP_006711985.1|refseq:XP_006711986.1|refseq:XP_011530789.1|refseq:XP_011530790.1|refseq:XP_016858671.1 refseq:NP_060289.2|ensembl:ENSG00000174173(gene)|ensembl:ENST00000309922(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0000964"(mitochondrial RNA 5'-end processing)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0009019"("tRNA (guanine-N1-)-methyltransferase activity")|go:"GO:0016429"("tRNA (adenine-N1-)-methyltransferase activity")|go:"GO:0030678"(mitochondrial ribonuclease P complex)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0042802"(identical protein binding)|go:"GO:0052905"("tRNA (guanine(9)-N(1))-methyltransferase activity")|go:"GO:0061953"("mRNA (adenine-N1-)-methyltransferase activity")|go:"GO:0070131"(positive regulation of mitochondrial translation)|go:"GO:0080009"(mRNA methylation)|go:"GO:0090646"(mitochondrial tRNA processing)|go:"GO:0097745"(mitochondrial tRNA 5'-end processing)|go:"GO:1990180"(mitochondrial tRNA 3'-end processing)|interpro:IPR007356("tRNA (guanine-N1-)-methyltransferase, eukaryotic")|interpro:IPR016009("tRNA (guanine-N1-)-methyltransferase")|interpro:IPR025812|interpro:IPR028564|interpro:IPR038459|mint:Q7L0Y3|rcsb pdb:5NFJ|reactome:R-HSA-6785470|reactome:R-HSA-6787450|reactome:R-HSA-8868766 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:AMLhskNenuv+zqXSa7VesSbbVK89606 rogid:ZvCWxNlWBon4eDq2zgzVTk3dI7U9606 intact-crc:0C994AD12CFA96BF|rigid:dXIDFwKFnSyKylhQY+vEZ/Pj2E4 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q53GS9 uniprotkb:Q8WTT2 intact:EBI-1044822|uniprotkb:Q6NX47|uniprotkb:Q96RK9|uniprotkb:Q9BV89|uniprotkb:Q9H381|uniprotkb:Q9P050|uniprotkb:Q9Y310|uniprotkb:A8K086|ensembl:ENSP00000312981|ensembl:ENSP00000386864|uniprotkb:D6W5L4|intact:EBI-2557627|uniprotkb:B4DHT4|uniprotkb:B3KM40|uniprotkb:G5E9H0 intact:EBI-2512539|ensembl:ENSP00000360412|uniprotkb:Q9H9D8|uniprotkb:Q9H5M6 psi-mi:snut2_human(display_long)|uniprotkb:U4/U6.U5 tri-snRNP-associated 65 kDa protein(gene name synonym)|uniprotkb:Inactive ubiquitin-specific peptidase 39(gene name synonym)|uniprotkb:SAD1 homolog(gene name synonym)|uniprotkb:USP39(gene name)|psi-mi:USP39(display_short)|uniprotkb:CGI-21(orf name)|uniprotkb:HSPC332(orf name)|uniprotkb:PRO2855(orf name) psi-mi:noc3l_human(display_long)|uniprotkb:NOC3L(gene name)|psi-mi:NOC3L(display_short)|uniprotkb:AD24(gene name synonym)|uniprotkb:C10orf117(gene name synonym)|uniprotkb:FAD24(gene name synonym)|uniprotkb:NOC3-like protein(gene name synonym)|uniprotkb:Nucleolar complex-associated protein 3-like protein(gene name synonym)|uniprotkb:Factor for adipocyte differentiation 24(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512555|imex:IM-12079-74 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006581.2|go:"GO:0008270"(zinc ion binding)|go:"GO:0008380"(RNA splicing)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0051301"(cell division)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR028889|interpro:IPR033809|interpro:IPR038765|go:"GO:0007049"(cell cycle)|rcsb pdb:3JCR|rcsb pdb:6AH0|rcsb pdb:6QW6|rcsb pdb:6QX9|reactome:R-HSA-72163|ensembl:ENSG00000168883(gene)|ensembl:ENST00000323701(transcript)|ensembl:ENST00000409470(transcript)|go:"GO:0000245"(spliceosomal complex assembly)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0006397"(mRNA processing)|refseq:NP_001243656.1|refseq:NP_001243657.1|refseq:NP_001243654.1|refseq:NP_001243655.1|refseq:XP_006711985.1|refseq:XP_006711986.1|refseq:XP_011530789.1|refseq:XP_011530790.1|refseq:XP_016858671.1 go:"GO:0005730"(nucleolus)|go:"GO:0005739"(mitochondrion)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0016607"(nuclear speck)|go:"GO:0045444"(fat cell differentiation)|interpro:IPR005612(CBF)|interpro:IPR011501(Nucleolar complex-associated)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016903(Nucleolar complex-associated protein 3)|mint:Q8WTT2|go:"GO:0005654"(nucleoplasm)|ensembl:ENSG00000173145(gene)|ensembl:ENST00000371361(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|refseq:NP_071896.8 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:AMLhskNenuv+zqXSa7VesSbbVK89606 rogid:s78IiBuQQjc0emiM/UkEMhzThVc9606 intact-crc:0C994AD12CFA96BF|rigid:dXIDFwKFnSyKylhQY+vEZ/Pj2E4 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q53GS9 uniprotkb:O43159 intact:EBI-1044822|uniprotkb:Q6NX47|uniprotkb:Q96RK9|uniprotkb:Q9BV89|uniprotkb:Q9H381|uniprotkb:Q9P050|uniprotkb:Q9Y310|uniprotkb:A8K086|ensembl:ENSP00000312981|ensembl:ENSP00000386864|uniprotkb:D6W5L4|intact:EBI-2557627|uniprotkb:B4DHT4|uniprotkb:B3KM40|uniprotkb:G5E9H0 intact:EBI-2008793|uniprotkb:Q7KZ78|uniprotkb:Q9BVM6|ensembl:ENSP00000254605 psi-mi:snut2_human(display_long)|uniprotkb:U4/U6.U5 tri-snRNP-associated 65 kDa protein(gene name synonym)|uniprotkb:Inactive ubiquitin-specific peptidase 39(gene name synonym)|uniprotkb:SAD1 homolog(gene name synonym)|uniprotkb:USP39(gene name)|psi-mi:USP39(display_short)|uniprotkb:CGI-21(orf name)|uniprotkb:HSPC332(orf name)|uniprotkb:PRO2855(orf name) psi-mi:rrp8_human(display_long)|uniprotkb:RRP8(gene name)|psi-mi:RRP8(display_short)|uniprotkb:hucep-1(orf name)|uniprotkb:NML(gene name synonym)|uniprotkb:Nucleomethylin(gene name synonym)|uniprotkb:KIAA0409(gene name synonym)|uniprotkb:Cerebral protein 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512555|imex:IM-12079-74 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006581.2|go:"GO:0008270"(zinc ion binding)|go:"GO:0008380"(RNA splicing)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0051301"(cell division)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR028889|interpro:IPR033809|interpro:IPR038765|go:"GO:0007049"(cell cycle)|rcsb pdb:3JCR|rcsb pdb:6AH0|rcsb pdb:6QW6|rcsb pdb:6QX9|reactome:R-HSA-72163|ensembl:ENSG00000168883(gene)|ensembl:ENST00000323701(transcript)|ensembl:ENST00000409470(transcript)|go:"GO:0000245"(spliceosomal complex assembly)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0006397"(mRNA processing)|refseq:NP_001243656.1|refseq:NP_001243657.1|refseq:NP_001243654.1|refseq:NP_001243655.1|refseq:XP_006711985.1|refseq:XP_006711986.1|refseq:XP_011530789.1|refseq:XP_011530790.1|refseq:XP_016858671.1 refseq:NP_056139.1|dip:DIP-46686N|ensembl:ENSG00000132275(gene)|ensembl:ENST00000254605(transcript)|go:"GO:0000183"(rDNA heterochromatin assembly)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005677"(chromatin silencing complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006364"(rRNA processing)|go:"GO:0008757"(S-adenosylmethionine-dependent methyltransferase activity)|go:"GO:0032259"(methylation)|go:"GO:0033553"(rDNA heterochromatin)|go:"GO:0035064"(methylated histone binding)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0046015"(regulation of transcription by glucose)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|interpro:IPR007823(Methyltransferase-related)|interpro:IPR023576|interpro:IPR029063|interpro:IPR042036|mint:O43159|rcsb pdb:2ZFU|reactome:R-HSA-427359 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:AMLhskNenuv+zqXSa7VesSbbVK89606 rogid:SNRPocKaPjMCXSLDe1ytWlUWYTw9606 intact-crc:0C994AD12CFA96BF|rigid:dXIDFwKFnSyKylhQY+vEZ/Pj2E4 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q53GS9 uniprotkb:Q9GZR7 intact:EBI-1044822|uniprotkb:Q6NX47|uniprotkb:Q96RK9|uniprotkb:Q9BV89|uniprotkb:Q9H381|uniprotkb:Q9P050|uniprotkb:Q9Y310|uniprotkb:A8K086|ensembl:ENSP00000312981|ensembl:ENSP00000386864|uniprotkb:D6W5L4|intact:EBI-2557627|uniprotkb:B4DHT4|uniprotkb:B3KM40|uniprotkb:G5E9H0 intact:EBI-713081|ensembl:ENSP00000481495|ensembl:ENSP00000482106|uniprotkb:E7EMJ4|uniprotkb:Q4V9L5 psi-mi:snut2_human(display_long)|uniprotkb:U4/U6.U5 tri-snRNP-associated 65 kDa protein(gene name synonym)|uniprotkb:Inactive ubiquitin-specific peptidase 39(gene name synonym)|uniprotkb:SAD1 homolog(gene name synonym)|uniprotkb:USP39(gene name)|psi-mi:USP39(display_short)|uniprotkb:CGI-21(orf name)|uniprotkb:HSPC332(orf name)|uniprotkb:PRO2855(orf name) psi-mi:ddx24_human(display_long)|uniprotkb:DEAD box protein 24(gene name synonym)|uniprotkb:DDX24(gene name)|psi-mi:DDX24(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512555|imex:IM-12079-74 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006581.2|go:"GO:0008270"(zinc ion binding)|go:"GO:0008380"(RNA splicing)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0051301"(cell division)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR028889|interpro:IPR033809|interpro:IPR038765|go:"GO:0007049"(cell cycle)|rcsb pdb:3JCR|rcsb pdb:6AH0|rcsb pdb:6QW6|rcsb pdb:6QX9|reactome:R-HSA-72163|ensembl:ENSG00000168883(gene)|ensembl:ENST00000323701(transcript)|ensembl:ENST00000409470(transcript)|go:"GO:0000245"(spliceosomal complex assembly)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0006397"(mRNA processing)|refseq:NP_001243656.1|refseq:NP_001243657.1|refseq:NP_001243654.1|refseq:NP_001243655.1|refseq:XP_006711985.1|refseq:XP_006711986.1|refseq:XP_011530789.1|refseq:XP_011530790.1|refseq:XP_016858671.1 ensembl:ENSG00000089737(gene)|ensembl:ENSG00000273761(gene)|ensembl:ENST00000613280(transcript)|ensembl:ENST00000621632(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005730"(nucleolus)|go:"GO:0016020"(membrane)|go:"GO:0016070"(RNA metabolic process)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR000629(RNA helicase, ATP-dependent, DEAD-box, conserved site)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR027417|mint:Q9GZR7|refseq:NP_065147.1|dip:DIP-47301N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:AMLhskNenuv+zqXSa7VesSbbVK89606 rogid:n9gQabTC50Y/LtGMAMFNVgj12as9606 intact-crc:0C994AD12CFA96BF|rigid:dXIDFwKFnSyKylhQY+vEZ/Pj2E4 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q53GS9 uniprotkb:O94906 intact:EBI-1044822|uniprotkb:Q6NX47|uniprotkb:Q96RK9|uniprotkb:Q9BV89|uniprotkb:Q9H381|uniprotkb:Q9P050|uniprotkb:Q9Y310|uniprotkb:A8K086|ensembl:ENSP00000312981|ensembl:ENSP00000386864|uniprotkb:D6W5L4|intact:EBI-2557627|uniprotkb:B4DHT4|uniprotkb:B3KM40|uniprotkb:G5E9H0 intact:EBI-536755|uniprotkb:O95109|uniprotkb:Q5VXS5|uniprotkb:Q9H3Z1|uniprotkb:Q9H4T9|uniprotkb:Q9H4U8|uniprotkb:Q9NTE6|ensembl:ENSP00000266079|uniprotkb:B2RAR5|uniprotkb:B3KMC6 psi-mi:snut2_human(display_long)|uniprotkb:U4/U6.U5 tri-snRNP-associated 65 kDa protein(gene name synonym)|uniprotkb:Inactive ubiquitin-specific peptidase 39(gene name synonym)|uniprotkb:SAD1 homolog(gene name synonym)|uniprotkb:USP39(gene name)|psi-mi:USP39(display_short)|uniprotkb:CGI-21(orf name)|uniprotkb:HSPC332(orf name)|uniprotkb:PRO2855(orf name) psi-mi:prp6_human(display_long)|uniprotkb:U5 snRNP-associated 102 kDa protein(gene name synonym)|uniprotkb:PRP6 homolog(gene name synonym)|uniprotkb:PRPF6(gene name)|psi-mi:PRPF6(display_short)|uniprotkb:C20orf14(gene name synonym)|uniprotkb:Androgen receptor N-terminal domain-transactivating protein 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512555|imex:IM-12079-74 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006581.2|go:"GO:0008270"(zinc ion binding)|go:"GO:0008380"(RNA splicing)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0051301"(cell division)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR028889|interpro:IPR033809|interpro:IPR038765|go:"GO:0007049"(cell cycle)|rcsb pdb:3JCR|rcsb pdb:6AH0|rcsb pdb:6QW6|rcsb pdb:6QX9|reactome:R-HSA-72163|ensembl:ENSG00000168883(gene)|ensembl:ENST00000323701(transcript)|ensembl:ENST00000409470(transcript)|go:"GO:0000245"(spliceosomal complex assembly)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0006397"(mRNA processing)|refseq:NP_001243656.1|refseq:NP_001243657.1|refseq:NP_001243654.1|refseq:NP_001243655.1|refseq:XP_006711985.1|refseq:XP_006711986.1|refseq:XP_011530789.1|refseq:XP_011530790.1|refseq:XP_016858671.1 ensembl:ENSG00000101161(gene)|ensembl:ENST00000266079(transcript)|go:"GO:0000244"(spliceosomal tri-snRNP complex assembly)|go:"GO:0000375"(RNA splicing, via transesterification reactions)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0000245"(spliceosomal complex assembly)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005682"(U5 snRNP)|go:"GO:0006403"(RNA localization)|go:"GO:0008380"(RNA splicing)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0042802"(identical protein binding)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|interpro:IPR003107(RNA-processing protein, HAT helix)|interpro:IPR010491(PRP1 splicing factor, N-terminal)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR027108|mint:O94906|rcsb pdb:3JCR|rcsb pdb:5O9Z|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6QW6|rcsb pdb:6QX9|reactome:R-HSA-72163|reactome:R-HSA-72165|refseq:NP_036601.2|dip:DIP-29006N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:AMLhskNenuv+zqXSa7VesSbbVK89606 rogid:M5ovIXl+1ob6VSKbXZUGU73J7Jk9606 intact-crc:0C994AD12CFA96BF|rigid:dXIDFwKFnSyKylhQY+vEZ/Pj2E4 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q53GS9 uniprotkb:O43172 intact:EBI-1044822|uniprotkb:Q6NX47|uniprotkb:Q96RK9|uniprotkb:Q9BV89|uniprotkb:Q9H381|uniprotkb:Q9P050|uniprotkb:Q9Y310|uniprotkb:A8K086|ensembl:ENSP00000312981|ensembl:ENSP00000386864|uniprotkb:D6W5L4|intact:EBI-2557627|uniprotkb:B4DHT4|uniprotkb:B3KM40|uniprotkb:G5E9H0 intact:EBI-718395|uniprotkb:O43445|uniprotkb:O43864|uniprotkb:Q96DG2|uniprotkb:Q96IK4|uniprotkb:Q5T1M8|ensembl:ENSP00000363315 psi-mi:snut2_human(display_long)|uniprotkb:U4/U6.U5 tri-snRNP-associated 65 kDa protein(gene name synonym)|uniprotkb:Inactive ubiquitin-specific peptidase 39(gene name synonym)|uniprotkb:SAD1 homolog(gene name synonym)|uniprotkb:USP39(gene name)|psi-mi:USP39(display_short)|uniprotkb:CGI-21(orf name)|uniprotkb:HSPC332(orf name)|uniprotkb:PRO2855(orf name) psi-mi:prp4_human(display_long)|uniprotkb:U4/U6 snRNP 60 kDa protein(gene name synonym)|uniprotkb:WD splicing factor Prp4(gene name synonym)|uniprotkb:PRP4 homolog(gene name synonym)|uniprotkb:PRPF4(gene name)|psi-mi:PRPF4(display_short)|uniprotkb:PRP4(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512555|imex:IM-12079-74 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006581.2|go:"GO:0008270"(zinc ion binding)|go:"GO:0008380"(RNA splicing)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0051301"(cell division)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR028889|interpro:IPR033809|interpro:IPR038765|go:"GO:0007049"(cell cycle)|rcsb pdb:3JCR|rcsb pdb:6AH0|rcsb pdb:6QW6|rcsb pdb:6QX9|reactome:R-HSA-72163|ensembl:ENSG00000168883(gene)|ensembl:ENST00000323701(transcript)|ensembl:ENST00000409470(transcript)|go:"GO:0000245"(spliceosomal complex assembly)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0006397"(mRNA processing)|refseq:NP_001243656.1|refseq:NP_001243657.1|refseq:NP_001243654.1|refseq:NP_001243655.1|refseq:XP_006711985.1|refseq:XP_006711986.1|refseq:XP_011530789.1|refseq:XP_011530790.1|refseq:XP_016858671.1 refseq:NP_004688.2|refseq:NP_001231855.1|ensembl:ENSG00000136875(gene)|ensembl:ENST00000374199(transcript)|go:"GO:0000375"(RNA splicing, via transesterification reactions)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0071001"(U4/U6 snRNP)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0097525"(spliceosomal snRNP complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR014906("Pre-mRNA processing factor 4 (PRP4) like")|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|interpro:IPR015943(WD40/YVTN repeat-like)|go:"GO:0006396"(RNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0015030"(Cajal body)|go:"GO:0016607"(nuclear speck)|go:"GO:0017070"(U6 snRNA binding)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036285|interpro:IPR036322|mint:O43172|rcsb pdb:1MZW|rcsb pdb:3JCR|rcsb pdb:5O9Z|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6QW6|rcsb pdb:6QX9|reactome:R-HSA-72163|go:"GO:0030621"(U4 snRNA binding) psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:AMLhskNenuv+zqXSa7VesSbbVK89606 rogid:PPTNuhEFj4D+gTv/ctTTMzGmFA09606 intact-crc:0C994AD12CFA96BF|rigid:dXIDFwKFnSyKylhQY+vEZ/Pj2E4 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q53GS9 uniprotkb:O95400 intact:EBI-1044822|uniprotkb:Q6NX47|uniprotkb:Q96RK9|uniprotkb:Q9BV89|uniprotkb:Q9H381|uniprotkb:Q9P050|uniprotkb:Q9Y310|uniprotkb:A8K086|ensembl:ENSP00000312981|ensembl:ENSP00000386864|uniprotkb:D6W5L4|intact:EBI-2557627|uniprotkb:B4DHT4|uniprotkb:B3KM40|uniprotkb:G5E9H0 intact:EBI-768015|uniprotkb:Q9ULP2|uniprotkb:B2RDX2|ensembl:ENSP00000304903|ensembl:ENSP00000456935 psi-mi:snut2_human(display_long)|uniprotkb:U4/U6.U5 tri-snRNP-associated 65 kDa protein(gene name synonym)|uniprotkb:Inactive ubiquitin-specific peptidase 39(gene name synonym)|uniprotkb:SAD1 homolog(gene name synonym)|uniprotkb:USP39(gene name)|psi-mi:USP39(display_short)|uniprotkb:CGI-21(orf name)|uniprotkb:HSPC332(orf name)|uniprotkb:PRO2855(orf name) psi-mi:cd2b2_human(display_long)|uniprotkb:CD2BP2(gene name)|psi-mi:CD2BP2(display_short)|uniprotkb:KIAA1178(gene name synonym)|uniprotkb:U5 snRNP 52K protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512555|imex:IM-12079-74 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_006581.2|go:"GO:0008270"(zinc ion binding)|go:"GO:0008380"(RNA splicing)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0051301"(cell division)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR028889|interpro:IPR033809|interpro:IPR038765|go:"GO:0007049"(cell cycle)|rcsb pdb:3JCR|rcsb pdb:6AH0|rcsb pdb:6QW6|rcsb pdb:6QX9|reactome:R-HSA-72163|ensembl:ENSG00000168883(gene)|ensembl:ENST00000323701(transcript)|ensembl:ENST00000409470(transcript)|go:"GO:0000245"(spliceosomal complex assembly)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0006397"(mRNA processing)|refseq:NP_001243656.1|refseq:NP_001243657.1|refseq:NP_001243654.1|refseq:NP_001243655.1|refseq:XP_006711985.1|refseq:XP_006711986.1|refseq:XP_011530789.1|refseq:XP_011530790.1|refseq:XP_016858671.1 refseq:NP_001230575.1|refseq:NP_006101.1|ensembl:ENSG00000169217(gene)|ensembl:ENST00000305596(transcript)|ensembl:ENST00000569466(transcript)|go:"GO:0000244"(spliceosomal tri-snRNP complex assembly)|go:"GO:0001650"(fibrillar center)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005682"(U5 snRNP)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016607"(nuclear speck)|go:"GO:0043021"(ribonucleoprotein complex binding)|interpro:IPR003169(GYF)|interpro:IPR035445|interpro:IPR039905|mint:O95400|rcsb pdb:1GYF|rcsb pdb:1L2Z|rcsb pdb:1SYX|rcsb pdb:4BWS|reactome:R-HSA-72163 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:AMLhskNenuv+zqXSa7VesSbbVK89606 rogid:eE6hXTyt05DhzzofcS/QJmUsLEY9606 intact-crc:0C994AD12CFA96BF|rigid:dXIDFwKFnSyKylhQY+vEZ/Pj2E4 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y6I4 uniprotkb:Q07954 intact:EBI-2512643|ensembl:ENSP00000369681|uniprotkb:Q8WVD0|uniprotkb:B4DVU5|uniprotkb:F5H1A6 intact:EBI-1046087|uniprotkb:Q8IVG8|uniprotkb:Q2PP12|uniprotkb:Q86SW0|ensembl:ENSP00000243077 psi-mi:ubp3_human(display_long)|uniprotkb:USP3(gene name)|psi-mi:USP3(display_short)|uniprotkb:Ubiquitin-specific-processing protease 3(gene name synonym)|uniprotkb:Deubiquitinating enzyme 3(gene name synonym)|uniprotkb:Ubiquitin thioesterase 3(gene name synonym) psi-mi:lrp1_human(display_long)|uniprotkb:Alpha-2-macroglobulin receptor(gene name synonym)|uniprotkb:Apolipoprotein E receptor(gene name synonym)|uniprotkb:LRP1(gene name)|psi-mi:LRP1(display_short)|uniprotkb:A2MR(gene name synonym)|uniprotkb:APR(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512627|imex:IM-12079-24 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000140455(gene)|ensembl:ENST00000380324(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016578"(histone deubiquitination)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042393"(histone binding)|go:"GO:0090543"(Flemming body)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|reactome:R-HSA-5689880|refseq:NP_006528.2|refseq:NP_001243631.1|dip:DIP-53585N refseq:NP_002323.2|ensembl:ENSG00000123384(gene)|ensembl:ENST00000243077(transcript)|go:"GO:0001523"(retinoid metabolic process)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0002020"(protease binding)|go:"GO:0002265"(astrocyte activation involved in immune response)|go:"GO:0003723"(RNA binding)|go:"GO:0005041"(low-density lipoprotein particle receptor activity)|go:"GO:0005044"(scavenger receptor activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005925"(focal adhesion)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006909"(phagocytosis)|go:"GO:0007041"(lysosomal transport)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007205"(protein kinase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0007568"(aging)|go:"GO:0008283"(cell population proliferation)|go:"GO:0010715"(regulation of extracellular matrix disassembly)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014912"(negative regulation of smooth muscle cell migration)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016964"(alpha-2 macroglobulin receptor activity)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030226"(apolipoprotein receptor activity)|go:"GO:0030425"(dendrite)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031623"(receptor internalization)|go:"GO:0032050"(clathrin heavy chain binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032370"(positive regulation of lipid transport)|go:"GO:0032374"(regulation of cholesterol transport)|go:"GO:0032429"(regulation of phospholipase A2 activity)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0034185"(apolipoprotein binding)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0035909"(aorta morphogenesis)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0038024"(cargo receptor activity)|go:"GO:0042157"(lipoprotein metabolic process)|go:"GO:0042953"(lipoprotein transport)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043235"(receptor complex)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0043395"(heparan sulfate proteoglycan binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044242"(cellular lipid catabolic process)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045056"(transcytosis)|go:"GO:0045177"(apical part of cell)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0048691"(positive regulation of axon extension involved in regeneration)|go:"GO:0048694"(positive regulation of collateral sprouting of injured axon)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:0061642"(chemoattraction of axon)|go:"GO:0070325"(lipoprotein particle receptor binding)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0098797"(plasma membrane protein complex)|go:"GO:0150093"(amyloid-beta clearance by transcytosis)|go:"GO:0150094"(amyloid-beta clearance by cellular catabolic process)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1900149"(positive regulation of Schwann cell migration)|go:"GO:1900223"(positive regulation of amyloid-beta clearance)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1904109"(positive regulation of cholesterol import)|go:"GO:1904300"(positive regulation of transcytosis)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|go:"GO:1905049"(negative regulation of metallopeptidase activity)|go:"GO:1905167"(positive regulation of lysosomal protein catabolic process)|go:"GO:2000343"("positive regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2000587"(negative regulation of platelet-derived growth factor receptor-beta signaling pathway)|interpro:IPR000033(Low-density lipoprotein receptor, YWTD repeat)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR002172(Low density lipoprotein-receptor, class A, cysteine-rich)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR011042(Six-bladed beta-propeller, TolB-like)|interpro:IPR018097|interpro:IPR023415|interpro:IPR026823|interpro:IPR032485|interpro:IPR036055|rcsb pdb:1CR8|rcsb pdb:1D2L|rcsb pdb:1J8E|rcsb pdb:2FYJ|rcsb pdb:2FYL|rcsb pdb:2KNX|rcsb pdb:2KNY|reactome:R-HSA-2168880|reactome:R-HSA-975634|dip:DIP-50613N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:036gyrDoXUao0ijci4SkCcYBAAE9606 rogid:eO2l3huuq6NYoVoYdoCloLqrlRw9606 intact-crc:7A0438F7CDE75EB2|rigid:L2VYO7gHOvCKNZ6u68FcqYpVXIg false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y6I4 uniprotkb:Q14344 intact:EBI-2512643|ensembl:ENSP00000369681|uniprotkb:Q8WVD0|uniprotkb:B4DVU5|uniprotkb:F5H1A6 intact:EBI-465387|ensembl:ENSP00000400717|uniprotkb:Q8TD70|uniprotkb:B7Z7R0|uniprotkb:F5H1G8|uniprotkb:B2R977 psi-mi:ubp3_human(display_long)|uniprotkb:USP3(gene name)|psi-mi:USP3(display_short)|uniprotkb:Ubiquitin-specific-processing protease 3(gene name synonym)|uniprotkb:Deubiquitinating enzyme 3(gene name synonym)|uniprotkb:Ubiquitin thioesterase 3(gene name synonym) psi-mi:gna13_human(display_long)|uniprotkb:GNA13(gene name)|psi-mi:GNA13(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512627|imex:IM-12079-24 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000140455(gene)|ensembl:ENST00000380324(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016578"(histone deubiquitination)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042393"(histone binding)|go:"GO:0090543"(Flemming body)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|reactome:R-HSA-5689880|refseq:NP_006528.2|refseq:NP_001243631.1|dip:DIP-53585N ensembl:ENSG00000120063(gene)|ensembl:ENST00000439174(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0031526"(brush border membrane)|go:"GO:0031584"(activation of phospholipase D activity)|go:"GO:0031683"(G-protein beta/gamma-subunit complex binding)|go:"GO:0031752"(D5 dopamine receptor binding)|go:"GO:0042470"(melanosome)|go:"GO:0046872"(metal ion binding)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904753"(negative regulation of vascular associated smooth muscle cell migration)|interpro:IPR000469(G-protein alpha subunit, group 12)|interpro:IPR001019("Guanine nucleotide binding protein (G-protein), alpha subunit")|interpro:IPR011025(G protein alpha subunit, helical insertion)|interpro:IPR027417|reactome:R-HSA-193648|reactome:R-HSA-416482|reactome:R-HSA-428930|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-456926|refseq:NP_006563.2|refseq:NP_001269354.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:036gyrDoXUao0ijci4SkCcYBAAE9606 rogid:ZYmlpIogjya3/ejteQS1YC+LqKI9606 intact-crc:7A0438F7CDE75EB2|rigid:L2VYO7gHOvCKNZ6u68FcqYpVXIg false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y6I4 uniprotkb:O95065 intact:EBI-2512643|ensembl:ENSP00000369681|uniprotkb:Q8WVD0|uniprotkb:B4DVU5|uniprotkb:F5H1A6 intact:EBI-2510439 psi-mi:ubp3_human(display_long)|uniprotkb:USP3(gene name)|psi-mi:USP3(display_short)|uniprotkb:Ubiquitin-specific-processing protease 3(gene name synonym)|uniprotkb:Deubiquitinating enzyme 3(gene name synonym)|uniprotkb:Ubiquitin thioesterase 3(gene name synonym) psi-mi:o95065_human(display_long) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512627|imex:IM-12079-24 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000140455(gene)|ensembl:ENST00000380324(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016578"(histone deubiquitination)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042393"(histone binding)|go:"GO:0090543"(Flemming body)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|reactome:R-HSA-5689880|refseq:NP_006528.2|refseq:NP_001243631.1|dip:DIP-53585N go:"GO:0003729"(mRNA binding)|go:"GO:0003743"(translation initiation factor activity)|refseq:NP_886553.3|interpro:IPR037584 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:036gyrDoXUao0ijci4SkCcYBAAE9606 rogid:s6TwW41esxJqcvLZsfvjgqS4SiM9606 intact-crc:7A0438F7CDE75EB2|rigid:L2VYO7gHOvCKNZ6u68FcqYpVXIg false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y6I4 uniprotkb:Q8N5D0 intact:EBI-2512643|ensembl:ENSP00000369681|uniprotkb:Q8WVD0|uniprotkb:B4DVU5|uniprotkb:F5H1A6 intact:EBI-311222|uniprotkb:Q9NV87|uniprotkb:Q9UPW4|intact:EBI-2559106|uniprotkb:Q5SSC5|uniprotkb:D3DPL5|ensembl:ENSP00000317971 psi-mi:ubp3_human(display_long)|uniprotkb:USP3(gene name)|psi-mi:USP3(display_short)|uniprotkb:Ubiquitin-specific-processing protease 3(gene name synonym)|uniprotkb:Deubiquitinating enzyme 3(gene name synonym)|uniprotkb:Ubiquitin thioesterase 3(gene name synonym) psi-mi:wdtc1_human(display_long)|uniprotkb:WDTC1(gene name)|psi-mi:WDTC1(display_short)|uniprotkb:KIAA1037(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512627|imex:IM-12079-24 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000140455(gene)|ensembl:ENST00000380324(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016578"(histone deubiquitination)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042393"(histone binding)|go:"GO:0090543"(Flemming body)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|reactome:R-HSA-5689880|refseq:NP_006528.2|refseq:NP_001243631.1|dip:DIP-53585N refseq:NP_055838.2|ensembl:ENSG00000142784(gene)|ensembl:ENST00000319394(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0008361"(regulation of cell size)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0042393"(histone binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045717"(negative regulation of fatty acid biosynthetic process)|go:"GO:0055082"(cellular chemical homeostasis)|go:"GO:0080008"(Cul4-RING E3 ubiquitin ligase complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019734|interpro:IPR036322|rcsb pdb:3I7N|reactome:R-HSA-8951664|refseq:XP_011539359.1|refseq:NP_001263181.1|dip:DIP-31627N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:036gyrDoXUao0ijci4SkCcYBAAE9606 rogid:jAsFFwoAfRkN+OVv32DRidscyi09606 intact-crc:7A0438F7CDE75EB2|rigid:L2VYO7gHOvCKNZ6u68FcqYpVXIg false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y6I4 uniprotkb:Q9BX72 intact:EBI-2512643|ensembl:ENSP00000369681|uniprotkb:Q8WVD0|uniprotkb:B4DVU5|uniprotkb:F5H1A6 intact:EBI-2510442 psi-mi:ubp3_human(display_long)|uniprotkb:USP3(gene name)|psi-mi:USP3(display_short)|uniprotkb:Ubiquitin-specific-processing protease 3(gene name synonym)|uniprotkb:Deubiquitinating enzyme 3(gene name synonym)|uniprotkb:Ubiquitin thioesterase 3(gene name synonym) psi-mi:q9bx72_human(display_long)|uniprotkb:IFP38(gene name)|psi-mi:IFP38(display_short)|uniprotkb:EIF3F(gene name synonym)|uniprotkb:EIF3S5(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 5(gene name synonym)|uniprotkb:eIF-3-epsilon(gene name synonym)|uniprotkb:eIF3 p47(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512627|imex:IM-12079-24 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000140455(gene)|ensembl:ENST00000380324(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016578"(histone deubiquitination)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042393"(histone binding)|go:"GO:0090543"(Flemming body)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|reactome:R-HSA-5689880|refseq:NP_006528.2|refseq:NP_001243631.1|dip:DIP-53585N go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0070122"(isopeptidase activity)|interpro:IPR024969|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR027531|interpro:IPR037518 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:036gyrDoXUao0ijci4SkCcYBAAE9606 rogid:OOc3qYL+oLa30X9bNDW8IpmYvkA9606 intact-crc:7A0438F7CDE75EB2|rigid:L2VYO7gHOvCKNZ6u68FcqYpVXIg false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y6I4 uniprotkb:O15034 intact:EBI-2512643|ensembl:ENSP00000369681|uniprotkb:Q8WVD0|uniprotkb:B4DVU5|uniprotkb:F5H1A6 intact:EBI-2512648|intact:EBI-28983594|ensembl:ENSP00000261655|uniprotkb:Q96ID2 psi-mi:ubp3_human(display_long)|uniprotkb:USP3(gene name)|psi-mi:USP3(display_short)|uniprotkb:Ubiquitin-specific-processing protease 3(gene name synonym)|uniprotkb:Deubiquitinating enzyme 3(gene name synonym)|uniprotkb:Ubiquitin thioesterase 3(gene name synonym) psi-mi:rimb2_human(display_long)|uniprotkb:RIMBP2(gene name)|psi-mi:RIMBP2(display_short)|uniprotkb:KIAA0318(gene name synonym)|uniprotkb:RBP2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512627|imex:IM-12079-24 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000140455(gene)|ensembl:ENST00000380324(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016578"(histone deubiquitination)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042393"(histone binding)|go:"GO:0090543"(Flemming body)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|reactome:R-HSA-5689880|refseq:NP_006528.2|refseq:NP_001243631.1|dip:DIP-53585N ensembl:ENSG00000060709(gene)|ensembl:ENST00000261655(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0007274"(neuromuscular synaptic transmission)|go:"GO:0045202"(synapse)|interpro:IPR001452(Src homology-3)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR035519|interpro:IPR035753|interpro:IPR035755|interpro:IPR036028|interpro:IPR036116|interpro:IPR040325|rcsb pdb:1WIE|rcsb pdb:2CSI|rcsb pdb:2CSP|rcsb pdb:2CSQ|ensembl:ENSP00000261655|refseq:NP_056162.4 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:036gyrDoXUao0ijci4SkCcYBAAE9606 rogid:poJ/MI+hMdizT9v0sb3u5blhZgY9606 intact-crc:7A0438F7CDE75EB2|rigid:L2VYO7gHOvCKNZ6u68FcqYpVXIg false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y6I4 uniprotkb:B3KSH1 intact:EBI-2512643|ensembl:ENSP00000369681|uniprotkb:Q8WVD0|uniprotkb:B4DVU5|uniprotkb:F5H1A6 intact:EBI-2510457 psi-mi:ubp3_human(display_long)|uniprotkb:USP3(gene name)|psi-mi:USP3(display_short)|uniprotkb:Ubiquitin-specific-processing protease 3(gene name synonym)|uniprotkb:Deubiquitinating enzyme 3(gene name synonym)|uniprotkb:Ubiquitin thioesterase 3(gene name synonym) psi-mi:b3ksh1_human(display_long)|uniprotkb:EIF3F(gene name)|psi-mi:EIF3F(display_short)|uniprotkb:EIF3S5(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 5(gene name synonym)|uniprotkb:eIF-3-epsilon(gene name synonym)|uniprotkb:eIF3 p47(gene name synonym)|uniprotkb:hCG_1784554(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512627|imex:IM-12079-24 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000140455(gene)|ensembl:ENST00000380324(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016578"(histone deubiquitination)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042393"(histone binding)|go:"GO:0090543"(Flemming body)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|reactome:R-HSA-5689880|refseq:NP_006528.2|refseq:NP_001243631.1|dip:DIP-53585N go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0070122"(isopeptidase activity)|interpro:IPR024969|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR027531|interpro:IPR037518 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:036gyrDoXUao0ijci4SkCcYBAAE9606 rogid:3xYNX/dcd5LtW8Ne+TP0TYHEUqY9606 intact-crc:7A0438F7CDE75EB2|rigid:L2VYO7gHOvCKNZ6u68FcqYpVXIg false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y6I4 uniprotkb:O15372 intact:EBI-2512643|ensembl:ENSP00000369681|uniprotkb:Q8WVD0|uniprotkb:B4DVU5|uniprotkb:F5H1A6 intact:EBI-709735|ensembl:ENSP00000429931 psi-mi:ubp3_human(display_long)|uniprotkb:USP3(gene name)|psi-mi:USP3(display_short)|uniprotkb:Ubiquitin-specific-processing protease 3(gene name synonym)|uniprotkb:Deubiquitinating enzyme 3(gene name synonym)|uniprotkb:Ubiquitin thioesterase 3(gene name synonym) psi-mi:eif3h_human(display_long)|uniprotkb:EIF3S3(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 3(gene name synonym)|uniprotkb:eIF-3-gamma(gene name synonym)|uniprotkb:eIF3 p40 subunit(gene name synonym)|uniprotkb:EIF3H(gene name)|psi-mi:EIF3H(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512627|imex:IM-12079-24 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000140455(gene)|ensembl:ENST00000380324(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016578"(histone deubiquitination)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042393"(histone binding)|go:"GO:0090543"(Flemming body)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|reactome:R-HSA-5689880|refseq:NP_006528.2|refseq:NP_001243631.1|dip:DIP-53585N refseq:NP_003747.1|ensembl:ENSG00000147677(gene)|ensembl:ENST00000521861(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070122"(isopeptidase activity)|go:"GO:0071541"(eukaryotic translation initiation factor 3 complex, eIF3m)|go:"GO:0101005"(deubiquitinase activity)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR027524|interpro:IPR037518|mint:O15372|rcsb pdb:3J8B|rcsb pdb:3J8C|rcsb pdb:6YBD|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|dip:DIP-33689N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:036gyrDoXUao0ijci4SkCcYBAAE9606 rogid:p1S78JRQsXwUzzAJkG02ABVWTNs9606 intact-crc:7A0438F7CDE75EB2|rigid:L2VYO7gHOvCKNZ6u68FcqYpVXIg false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y6I4 uniprotkb:Q14152 intact:EBI-2512643|ensembl:ENSP00000369681|uniprotkb:Q8WVD0|uniprotkb:B4DVU5|uniprotkb:F5H1A6 intact:EBI-366617|uniprotkb:O00653|uniprotkb:Q15778|uniprotkb:B1AMV5|intact:EBI-28978176|ensembl:ENSP00000358140|ensembl:ENSP00000438178|uniprotkb:B4DYS1|uniprotkb:F5H335 psi-mi:ubp3_human(display_long)|uniprotkb:USP3(gene name)|psi-mi:USP3(display_short)|uniprotkb:Ubiquitin-specific-processing protease 3(gene name synonym)|uniprotkb:Deubiquitinating enzyme 3(gene name synonym)|uniprotkb:Ubiquitin thioesterase 3(gene name synonym) psi-mi:eif3a_human(display_long)|uniprotkb:EIF3A(gene name)|psi-mi:EIF3A(display_short)|uniprotkb:KIAA0139(gene name synonym)|uniprotkb:EIF3S10(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 10(gene name synonym)|uniprotkb:eIF-3-theta(gene name synonym)|uniprotkb:eIF3 p167(gene name synonym)|uniprotkb:eIF3 p180(gene name synonym)|uniprotkb:eIF3 p185(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512627|imex:IM-12079-24 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000140455(gene)|ensembl:ENST00000380324(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016578"(histone deubiquitination)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042393"(histone binding)|go:"GO:0090543"(Flemming body)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|reactome:R-HSA-5689880|refseq:NP_006528.2|refseq:NP_001243631.1|dip:DIP-53585N refseq:NP_003741.1|ensembl:ENSP00000358140|ensembl:ENSP00000438178|ensembl:ENSG00000107581(gene)|ensembl:ENST00000369144(transcript)|ensembl:ENST00000541549(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0002188"(translation reinitiation)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0005874"(microtubule)|go:"GO:0006413"(translational initiation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0043614"(multi-eIF complex)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071540"(eukaryotic translation initiation factor 3 complex, eIF3e)|go:"GO:0071541"(eukaryotic translation initiation factor 3 complex, eIF3m)|go:"GO:0075522"(IRES-dependent viral translational initiation)|go:"GO:0075525"(viral translational termination-reinitiation)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR027512|mint:Q14152|rcsb pdb:3J8B|rcsb pdb:3J8C|rcsb pdb:6YBD|rcsb pdb:6YBT|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|dip:DIP-31114N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:036gyrDoXUao0ijci4SkCcYBAAE9606 rogid:COyPBU7e0SUL3BiZY7NQuUkmxns9606 intact-crc:7A0438F7CDE75EB2|rigid:L2VYO7gHOvCKNZ6u68FcqYpVXIg false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y6I4 uniprotkb:P30613 intact:EBI-2512643|ensembl:ENSP00000369681|uniprotkb:Q8WVD0|uniprotkb:B4DVU5|uniprotkb:F5H1A6 intact:EBI-2117450|uniprotkb:P11973|uniprotkb:O75758|ensembl:ENSP00000339933|ensembl:ENSP00000459921 psi-mi:ubp3_human(display_long)|uniprotkb:USP3(gene name)|psi-mi:USP3(display_short)|uniprotkb:Ubiquitin-specific-processing protease 3(gene name synonym)|uniprotkb:Deubiquitinating enzyme 3(gene name synonym)|uniprotkb:Ubiquitin thioesterase 3(gene name synonym) psi-mi:kpyr_human(display_long)|uniprotkb:Pyruvate kinase isozymes L/R(gene name synonym)|uniprotkb:PKLR(gene name)|psi-mi:PKLR(display_short)|uniprotkb:PK1(gene name synonym)|uniprotkb:PKL(gene name synonym)|uniprotkb:R-type/L-type pyruvate kinase(gene name synonym)|uniprotkb:Red cell/liver pyruvate kinase(gene name synonym)|uniprotkb:Pyruvate kinase 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512627|imex:IM-12079-24 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000140455(gene)|ensembl:ENST00000380324(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016578"(histone deubiquitination)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042393"(histone binding)|go:"GO:0090543"(Flemming body)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|reactome:R-HSA-5689880|refseq:NP_006528.2|refseq:NP_001243631.1|dip:DIP-53585N refseq:NP_000289.1|refseq:NP_870986.1|ensembl:ENSG00000143627(gene)|ensembl:ENSG00000262785(gene)|ensembl:ENST00000342741(transcript)|ensembl:ENST00000572740(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0004743"(pyruvate kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006096"(glycolytic process)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0007584"(response to nutrient)|go:"GO:0009408"(response to heat)|go:"GO:0009749"(response to glucose)|go:"GO:0010226"(response to lithium ion)|go:"GO:0016301"(kinase activity)|go:"GO:0030955"(potassium ion binding)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033198"(response to ATP)|go:"GO:0042866"(pyruvate biosynthetic process)|go:"GO:0051591"(response to cAMP)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071872"(cellular response to epinephrine stimulus)|interpro:IPR001697(Pyruvate kinase)|interpro:IPR011037(Pyruvate kinase, beta-barrel-like)|interpro:IPR015793(Pyruvate kinase, barrel)|interpro:IPR015795(Pyruvate kinase, C-terminal-like)|interpro:IPR015806(Pyruvate kinase, beta-barrel)|interpro:IPR015813(Pyruvate/Phosphoenolpyruvate kinase, catalytic core)|interpro:IPR018209|interpro:IPR036918|interpro:IPR040442|rcsb pdb:2VGB|rcsb pdb:2VGF|rcsb pdb:2VGG|rcsb pdb:2VGI|rcsb pdb:4IMA|rcsb pdb:4IP7|rcsb pdb:6NN4|rcsb pdb:6NN5|rcsb pdb:6NN7|rcsb pdb:6NN8|reactome:R-HSA-163765|reactome:R-HSA-210745|reactome:R-HSA-70171 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:036gyrDoXUao0ijci4SkCcYBAAE9606 rogid:7Dw4NAJv4qwG9bqTpNccySqPvhY9606 intact-crc:7A0438F7CDE75EB2|rigid:L2VYO7gHOvCKNZ6u68FcqYpVXIg false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y6I4 uniprotkb:P55884 intact:EBI-2512643|ensembl:ENSP00000369681|uniprotkb:Q8WVD0|uniprotkb:B4DVU5|uniprotkb:F5H1A6 intact:EBI-366696|uniprotkb:Q2NL77|uniprotkb:Q9UMF9|uniprotkb:A4D208|ensembl:ENSP00000354125|ensembl:ENSP00000380206 psi-mi:ubp3_human(display_long)|uniprotkb:USP3(gene name)|psi-mi:USP3(display_short)|uniprotkb:Ubiquitin-specific-processing protease 3(gene name synonym)|uniprotkb:Deubiquitinating enzyme 3(gene name synonym)|uniprotkb:Ubiquitin thioesterase 3(gene name synonym) psi-mi:eif3b_human(display_long)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 9(gene name synonym)|uniprotkb:eIF-3-eta(gene name synonym)|uniprotkb:eIF3 p116(gene name synonym)|uniprotkb:eIF3 p110(gene name synonym)|uniprotkb:Prt1 homolog(gene name synonym)|uniprotkb:EIF3B(gene name)|psi-mi:EIF3B(display_short)|uniprotkb:EIF3S9(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512627|imex:IM-12079-24 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000140455(gene)|ensembl:ENST00000380324(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016578"(histone deubiquitination)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042393"(histone binding)|go:"GO:0090543"(Flemming body)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|reactome:R-HSA-5689880|refseq:NP_006528.2|refseq:NP_001243631.1|dip:DIP-53585N refseq:NP_001032360.1|refseq:NP_003742.2|refseq:XP_011513901.1|refseq:XP_011513902.1|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0031369"(translation initiation factor binding)|ensembl:ENSG00000106263(gene)|ensembl:ENST00000360876(transcript)|ensembl:ENST00000397011(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0045202"(synapse)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071541"(eukaryotic translation initiation factor 3 complex, eIF3m)|go:"GO:0075522"(IRES-dependent viral translational initiation)|go:"GO:0075525"(viral translational termination-reinitiation)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR011400(Translation initiation factor eIF-3b)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR013979(Eukaryotic translation initiation factor 2A, central region)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR034363|interpro:IPR035979|mint:P55884|rcsb pdb:2KRB|rcsb pdb:2NLW|rcsb pdb:5K1H|rcsb pdb:6YBT|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|refseq:XP_016868241.1|dip:DIP-31113N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:036gyrDoXUao0ijci4SkCcYBAAE9606 rogid:MxQFPvmuOcO/S+4NqzToozWr8K89606 intact-crc:7A0438F7CDE75EB2|rigid:L2VYO7gHOvCKNZ6u68FcqYpVXIg false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y6I4 uniprotkb:O75828 intact:EBI-2512643|ensembl:ENSP00000369681|uniprotkb:Q8WVD0|uniprotkb:B4DVU5|uniprotkb:F5H1A6 intact:EBI-714504|ensembl:ENSP00000290354|uniprotkb:Q6FHP2 psi-mi:ubp3_human(display_long)|uniprotkb:USP3(gene name)|psi-mi:USP3(display_short)|uniprotkb:Ubiquitin-specific-processing protease 3(gene name synonym)|uniprotkb:Deubiquitinating enzyme 3(gene name synonym)|uniprotkb:Ubiquitin thioesterase 3(gene name synonym) psi-mi:cbr3_human(display_long)|uniprotkb:NADPH-dependent carbonyl reductase 3(gene name synonym)|uniprotkb:CBR3(gene name)|psi-mi:CBR3(display_short)|uniprotkb:Short chain dehydrogenase/reductase family 21C member 2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512627|imex:IM-12079-24 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000140455(gene)|ensembl:ENST00000380324(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016578"(histone deubiquitination)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042393"(histone binding)|go:"GO:0090543"(Flemming body)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|reactome:R-HSA-5689880|refseq:NP_006528.2|refseq:NP_001243631.1|dip:DIP-53585N ensembl:ENSG00000159231(gene)|ensembl:ENST00000290354(transcript)|go:"GO:0000253"(3-keto sterol reductase activity)|go:"GO:0004090"("carbonyl reductase (NADPH) activity")|go:"GO:0005615"(extracellular space)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006805"(xenobiotic metabolic process)|go:"GO:0042376"(phylloquinone catabolic process)|go:"GO:0050890"(cognition)|go:"GO:0070402"(NADPH binding)|interpro:IPR002347(Glucose/ribitol dehydrogenase)|interpro:IPR020904|interpro:IPR036291|rcsb pdb:2HRB|reactome:R-HSA-211945|refseq:NP_001227.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:036gyrDoXUao0ijci4SkCcYBAAE9606 rogid:31QYceUdGN2HanRmiei1aR9f8MI9606 intact-crc:7A0438F7CDE75EB2|rigid:L2VYO7gHOvCKNZ6u68FcqYpVXIg false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y6I4 uniprotkb:Q6DKJ4 intact:EBI-2512643|ensembl:ENSP00000369681|uniprotkb:Q8WVD0|uniprotkb:B4DVU5|uniprotkb:F5H1A6 intact:EBI-1055389|uniprotkb:Q3SWW6|uniprotkb:Q6P3U6|uniprotkb:Q9H9Q1|uniprotkb:B4DXQ0|uniprotkb:Q7L4C6|uniprotkb:D3DTH2|ensembl:ENSP00000337443 psi-mi:ubp3_human(display_long)|uniprotkb:USP3(gene name)|psi-mi:USP3(display_short)|uniprotkb:Ubiquitin-specific-processing protease 3(gene name synonym)|uniprotkb:Deubiquitinating enzyme 3(gene name synonym)|uniprotkb:Ubiquitin thioesterase 3(gene name synonym) psi-mi:nxn_human(display_long)|uniprotkb:NXN(gene name)|psi-mi:NXN(display_short)|uniprotkb:NRX(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512627|imex:IM-12079-24 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000140455(gene)|ensembl:ENST00000380324(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016578"(histone deubiquitination)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042393"(histone binding)|go:"GO:0090543"(Flemming body)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|reactome:R-HSA-5689880|refseq:NP_006528.2|refseq:NP_001243631.1|dip:DIP-53585N refseq:NP_071908.2|refseq:NP_001192248.1|ensembl:ENST00000336868(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0004791"(thioredoxin-disulfide reductase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030154"(cell differentiation)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0072359"(circulatory system development)|interpro:IPR012336(Thioredoxin-like fold)|interpro:IPR013766(Thioredoxin domain)|interpro:IPR036249|interpro:IPR041861|mint:Q6DKJ4|ensembl:ENSG00000167693(gene) psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:036gyrDoXUao0ijci4SkCcYBAAE9606 rogid:xQsuChT9r8OMThUdFAfhMknlhzU9606 intact-crc:7A0438F7CDE75EB2|rigid:L2VYO7gHOvCKNZ6u68FcqYpVXIg false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y6I4 uniprotkb:Q9H496 intact:EBI-2512643|ensembl:ENSP00000369681|uniprotkb:Q8WVD0|uniprotkb:B4DVU5|uniprotkb:F5H1A6 intact:EBI-2510146|ensembl:ENSP00000485355|uniprotkb:Q05BU2 psi-mi:ubp3_human(display_long)|uniprotkb:USP3(gene name)|psi-mi:USP3(display_short)|uniprotkb:Ubiquitin-specific-processing protease 3(gene name synonym)|uniprotkb:Deubiquitinating enzyme 3(gene name synonym)|uniprotkb:Ubiquitin thioesterase 3(gene name synonym) psi-mi:ifg15_human(display_long)|uniprotkb:IFRG15(gene name synonym)|uniprotkb:TOR1AIP2(gene name)|psi-mi:TOR1AIP2(display_short)|uniprotkb:15 kDa interferon-responsive protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512627|imex:IM-12079-24 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000140455(gene)|ensembl:ENST00000380324(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016578"(histone deubiquitination)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042393"(histone binding)|go:"GO:0090543"(Flemming body)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|reactome:R-HSA-5689880|refseq:NP_006528.2|refseq:NP_001243631.1|dip:DIP-53585N ensembl:ENSG00000169905(gene)|ensembl:ENST00000482587(transcript)|refseq:NP_071742.1|refseq:XP_016855966.1|refseq:XP_016855967.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:036gyrDoXUao0ijci4SkCcYBAAE9606 rogid:JTZAx1BSMfctWtiQyePC82lYQnM9606 intact-crc:7A0438F7CDE75EB2|rigid:L2VYO7gHOvCKNZ6u68FcqYpVXIg false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y6I4 uniprotkb:Q99613 intact:EBI-2512643|ensembl:ENSP00000369681|uniprotkb:Q8WVD0|uniprotkb:B4DVU5|uniprotkb:F5H1A6 intact:EBI-353741|uniprotkb:A8K7Z0|intact:EBI-2876652|uniprotkb:O00215|uniprotkb:Q9BW98|uniprotkb:B2RXG3|intact:EBI-11017021|ensembl:ENSP00000332604|ensembl:ENSP00000378953|ensembl:ENSP00000457418|ensembl:ENSP00000457963|uniprotkb:B4E1D5|uniprotkb:H3BRV0 psi-mi:ubp3_human(display_long)|uniprotkb:USP3(gene name)|psi-mi:USP3(display_short)|uniprotkb:Ubiquitin-specific-processing protease 3(gene name synonym)|uniprotkb:Deubiquitinating enzyme 3(gene name synonym)|uniprotkb:Ubiquitin thioesterase 3(gene name synonym) psi-mi:eif3c_human(display_long)|uniprotkb:EIF3C(gene name)|psi-mi:EIF3C(display_short)|uniprotkb:EIF3S8(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 8(gene name synonym)|uniprotkb:eIF3 p110(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512627|imex:IM-12079-24 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000140455(gene)|ensembl:ENST00000380324(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016578"(histone deubiquitination)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042393"(histone binding)|go:"GO:0090543"(Flemming body)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|reactome:R-HSA-5689880|refseq:NP_006528.2|refseq:NP_001243631.1|dip:DIP-53585N refseq:NP_001032897.1|refseq:NP_001186071.1|refseq:NP_003743.1|refseq:NP_001273407.1|ensembl:ENSG00000184110(gene)|ensembl:ENST00000331666(transcript)|ensembl:ENST00000395587(transcript)|ensembl:ENST00000566501(transcript)|ensembl:ENST00000566866(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0043022"(ribosome binding)|go:"GO:0045727"(positive regulation of translation)|go:"GO:1902416"(positive regulation of mRNA binding)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR008905(Eukaryotic translation initiation factor 3 subunit 8, N-terminal)|interpro:IPR027516|interpro:IPR036388|interpro:IPR036390|mint:Q99613|rcsb pdb:3J8B|rcsb pdb:3J8C|rcsb pdb:6YBD|rcsb pdb:6YBW|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|refseq:NP_001254503.1|dip:DIP-32865N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:036gyrDoXUao0ijci4SkCcYBAAE9606 rogid:74XQwDW6yxVsob6wZNgfuBlB06M9606 intact-crc:7A0438F7CDE75EB2|rigid:L2VYO7gHOvCKNZ6u68FcqYpVXIg false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y6I4 uniprotkb:O75821 intact:EBI-2512643|ensembl:ENSP00000369681|uniprotkb:Q8WVD0|uniprotkb:B4DVU5|uniprotkb:F5H1A6 intact:EBI-366632|uniprotkb:O14801|uniprotkb:Q969U5|intact:EBI-28974438|ensembl:ENSP00000253108 psi-mi:ubp3_human(display_long)|uniprotkb:USP3(gene name)|psi-mi:USP3(display_short)|uniprotkb:Ubiquitin-specific-processing protease 3(gene name synonym)|uniprotkb:Deubiquitinating enzyme 3(gene name synonym)|uniprotkb:Ubiquitin thioesterase 3(gene name synonym) psi-mi:eif3g_human(display_long)|uniprotkb:EIF3G(gene name)|psi-mi:EIF3G(display_short)|uniprotkb:EIF3S4(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 4(gene name synonym)|uniprotkb:eIF-3-delta(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 RNA-binding subunit(gene name synonym)|uniprotkb:eIF3 p44(gene name synonym)|uniprotkb:eIF3 p42(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512627|imex:IM-12079-24 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000140455(gene)|ensembl:ENST00000380324(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016578"(histone deubiquitination)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042393"(histone binding)|go:"GO:0090543"(Flemming body)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|reactome:R-HSA-5689880|refseq:NP_006528.2|refseq:NP_001243631.1|dip:DIP-53585N ensembl:ENSP00000253108|refseq:NP_003746.2|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0075525"(viral translational termination-reinitiation)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR017334(Translation initiation factor 3, RNA-binding subunit)|interpro:IPR024675|interpro:IPR034240|interpro:IPR035979|mint:O75821|rcsb pdb:2CQ0|rcsb pdb:2MJC|rcsb pdb:5K0Y|rcsb pdb:6YBS|rcsb pdb:6ZMW|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|ensembl:ENSG00000130811(gene)|ensembl:ENST00000253108(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|dip:DIP-31115N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:036gyrDoXUao0ijci4SkCcYBAAE9606 rogid:ZHm8Il08Zyb6kFAavZo4tnuUN4g9606 intact-crc:7A0438F7CDE75EB2|rigid:L2VYO7gHOvCKNZ6u68FcqYpVXIg false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y6I4 uniprotkb:Q13347 intact:EBI-2512643|ensembl:ENSP00000369681|uniprotkb:Q8WVD0|uniprotkb:B4DVU5|uniprotkb:F5H1A6 intact:EBI-354047|intact:EBI-11759480|ensembl:ENSP00000504034|ensembl:ENSP00000504061|ensembl:ENSP00000502867|ensembl:ENSP00000503348|ensembl:ENSP00000503539 psi-mi:ubp3_human(display_long)|uniprotkb:USP3(gene name)|psi-mi:USP3(display_short)|uniprotkb:Ubiquitin-specific-processing protease 3(gene name synonym)|uniprotkb:Deubiquitinating enzyme 3(gene name synonym)|uniprotkb:Ubiquitin thioesterase 3(gene name synonym) psi-mi:eif3i_human(display_long)|uniprotkb:EIF3I(gene name)|psi-mi:EIF3I(display_short)|uniprotkb:TRIP1(gene name synonym)|uniprotkb:EIF3S2(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 2(gene name synonym)|uniprotkb:eIF-3-beta(gene name synonym)|uniprotkb:eIF3 p36(gene name synonym)|uniprotkb:TGF-beta receptor-interacting protein 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512627|imex:IM-12079-24 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000140455(gene)|ensembl:ENST00000380324(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016578"(histone deubiquitination)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042393"(histone binding)|go:"GO:0090543"(Flemming body)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|reactome:R-HSA-5689880|refseq:NP_006528.2|refseq:NP_001243631.1|dip:DIP-53585N refseq:NP_003748.1|ensembl:ENST00000676801(transcript)|ensembl:ENST00000677202(transcript)|ensembl:ENST00000677701(transcript)|ensembl:ENST00000677711(transcript)|ensembl:ENST00000677760(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0002183"(cytoplasmic translational initiation)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071541"(eukaryotic translation initiation factor 3 complex, eIF3m)|ensembl:ENSG00000084623(gene)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR027525|interpro:IPR036322|mint:Q13347|rcsb pdb:6YBT|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|dip:DIP-31116N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:036gyrDoXUao0ijci4SkCcYBAAE9606 rogid:fogC6nSNmIynV2ziHZboT9laA3M9606 intact-crc:7A0438F7CDE75EB2|rigid:L2VYO7gHOvCKNZ6u68FcqYpVXIg false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y6I4 uniprotkb:O15371 intact:EBI-2512643|ensembl:ENSP00000369681|uniprotkb:Q8WVD0|uniprotkb:B4DVU5|uniprotkb:F5H1A6 intact:EBI-353818|uniprotkb:Q3MJD9|uniprotkb:Q5M9Q6|uniprotkb:B2R7D4|intact:EBI-10969985|ensembl:ENSP00000216190|ensembl:ENSP00000385812|uniprotkb:A8MWD3|uniprotkb:B4DTF8|uniprotkb:B4DVY1 psi-mi:ubp3_human(display_long)|uniprotkb:USP3(gene name)|psi-mi:USP3(display_short)|uniprotkb:Ubiquitin-specific-processing protease 3(gene name synonym)|uniprotkb:Deubiquitinating enzyme 3(gene name synonym)|uniprotkb:Ubiquitin thioesterase 3(gene name synonym) psi-mi:eif3d_human(display_long)|uniprotkb:EIF3D(gene name)|psi-mi:EIF3D(display_short)|uniprotkb:EIF3S7(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 7(gene name synonym)|uniprotkb:eIF-3-zeta(gene name synonym)|uniprotkb:eIF3 p66(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512627|imex:IM-12079-24 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000140455(gene)|ensembl:ENST00000380324(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016578"(histone deubiquitination)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042393"(histone binding)|go:"GO:0090543"(Flemming body)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|reactome:R-HSA-5689880|refseq:NP_006528.2|refseq:NP_001243631.1|dip:DIP-53585N refseq:NP_003744.1|ensembl:ENSG00000100353(gene)|ensembl:ENST00000216190(transcript)|ensembl:ENST00000405442(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0002191"(cap-dependent translational initiation)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0016020"(membrane)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0071541"(eukaryotic translation initiation factor 3 complex, eIF3m)|go:"GO:0075522"(IRES-dependent viral translational initiation)|go:"GO:0075525"(viral translational termination-reinitiation)|go:"GO:0098808"(mRNA cap binding)|go:"GO:1902416"(positive regulation of mRNA binding)|interpro:IPR007783(Eukaryotic translation initiation factor 3, subunit 7)|mint:O15371|rcsb pdb:6YBD|rcsb pdb:6YBS|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|dip:DIP-32870N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:036gyrDoXUao0ijci4SkCcYBAAE9606 rogid:hw2nyiDfdecEhLmKA5U9+46bBag9606 intact-crc:7A0438F7CDE75EB2|rigid:L2VYO7gHOvCKNZ6u68FcqYpVXIg false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y6I4 uniprotkb:P38405 intact:EBI-2512643|ensembl:ENSP00000369681|uniprotkb:Q8WVD0|uniprotkb:B4DVU5|uniprotkb:F5H1A6 intact:EBI-2512639|ensembl:ENSP00000269162|ensembl:ENSP00000408489|ensembl:ENSP00000439023|uniprotkb:Q86XU3|uniprotkb:B7ZA26 psi-mi:ubp3_human(display_long)|uniprotkb:USP3(gene name)|psi-mi:USP3(display_short)|uniprotkb:Ubiquitin-specific-processing protease 3(gene name synonym)|uniprotkb:Deubiquitinating enzyme 3(gene name synonym)|uniprotkb:Ubiquitin thioesterase 3(gene name synonym) psi-mi:gnal_human(display_long)|uniprotkb:GNAL(gene name)|psi-mi:GNAL(display_short)|uniprotkb:Adenylate cyclase-stimulating G alpha protein, olfactory type(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512627|imex:IM-12079-24 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000140455(gene)|ensembl:ENST00000380324(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016578"(histone deubiquitination)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042393"(histone binding)|go:"GO:0090543"(Flemming body)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|reactome:R-HSA-5689880|refseq:NP_006528.2|refseq:NP_001243631.1|dip:DIP-53585N ensembl:ENSG00000141404(gene)|ensembl:ENST00000269162(transcript)|ensembl:ENST00000423027(transcript)|ensembl:ENST00000535121(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007191"(adenylate cyclase-activating dopamine receptor signaling pathway)|go:"GO:0007606"(sensory perception of chemical stimulus)|go:"GO:0031683"(G-protein beta/gamma-subunit complex binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000367(G-protein alpha subunit, group S)|interpro:IPR001019("Guanine nucleotide binding protein (G-protein), alpha subunit")|interpro:IPR011025(G protein alpha subunit, helical insertion)|interpro:IPR027417|reactome:R-HSA-170660|reactome:R-HSA-170670|reactome:R-HSA-381753|refseq:NP_001135811.1|refseq:NP_892023.1|refseq:NP_001248372.1|refseq:NP_001248373.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:036gyrDoXUao0ijci4SkCcYBAAE9606 rogid:IC+CI3TYQdbioxaPBNu/cSGn7TQ9606 intact-crc:7A0438F7CDE75EB2|rigid:L2VYO7gHOvCKNZ6u68FcqYpVXIg false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y6I4 uniprotkb:Q5JSZ5 intact:EBI-2512643|ensembl:ENSP00000369681|uniprotkb:Q8WVD0|uniprotkb:B4DVU5|uniprotkb:F5H1A6 intact:EBI-744891|uniprotkb:Q66VZ2|uniprotkb:Q9H683|uniprotkb:Q5JSZ7|uniprotkb:O60270|intact:EBI-2512629|intact:EBI-947989|uniprotkb:Q68CR0|intact:EBI-2559356|uniprotkb:Q96EI9|ensembl:ENSP00000508005|ensembl:ENSP00000508048 psi-mi:ubp3_human(display_long)|uniprotkb:USP3(gene name)|psi-mi:USP3(display_short)|uniprotkb:Ubiquitin-specific-processing protease 3(gene name synonym)|uniprotkb:Deubiquitinating enzyme 3(gene name synonym)|uniprotkb:Ubiquitin thioesterase 3(gene name synonym) psi-mi:prc2b_human(display_long)|uniprotkb:PRRC2B(gene name)|psi-mi:PRRC2B(display_short)|uniprotkb:HLA-B-associated transcript 2-like 1(gene name synonym)|uniprotkb:KIAA0515(gene name synonym)|uniprotkb:BAT2L(gene name synonym)|uniprotkb:BAT2L1(gene name synonym)|uniprotkb:Proline-rich coiled-coil protein 2B(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512627|imex:IM-12079-24 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000140455(gene)|ensembl:ENST00000380324(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016578"(histone deubiquitination)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042393"(histone binding)|go:"GO:0090543"(Flemming body)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|reactome:R-HSA-5689880|refseq:NP_006528.2|refseq:NP_001243631.1|dip:DIP-53585N refseq:NP_037450.2|ensembl:ENST00000682501|ensembl:ENSP00000508073|ensembl:ENSP00000508048|ensembl:ENSP00000508005|ensembl:ENSG00000288701(gene)|ensembl:ENST00000683519(transcript)|ensembl:ENST00000684596(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0030154"(cell differentiation)|interpro:IPR009738(BAT2, N-terminal)|interpro:IPR033184|mint:Q5JSZ5 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:036gyrDoXUao0ijci4SkCcYBAAE9606 rogid:N1MgJl3k+WJTF+XUf5VFIB06B909606 intact-crc:7A0438F7CDE75EB2|rigid:L2VYO7gHOvCKNZ6u68FcqYpVXIg false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q70EL4 uniprotkb:Q5TCQ9 intact:EBI-2512700|ensembl:ENSP00000285199|uniprotkb:Q8N2C5|uniprotkb:A6NDT9|uniprotkb:Q96DQ6|uniprotkb:B7ZLT9|uniprotkb:B7ZVX5 intact:EBI-310506|uniprotkb:Q5TCR0|uniprotkb:Q9H2V6|uniprotkb:Q5TCQ8|uniprotkb:Q9H5Y8|uniprotkb:Q9HBC4|intact:EBI-2512710|intact:EBI-991068|ensembl:ENSP00000304604|uniprotkb:Q9HCD8|uniprotkb:A0A024R0E9|uniprotkb:A0A024R0H3 psi-mi:ubp43_human(display_long)|uniprotkb:USP43(gene name)|psi-mi:USP43(display_short)|uniprotkb:Ubiquitin-specific-processing protease 43(gene name synonym)|uniprotkb:Deubiquitinating enzyme 43(gene name synonym)|uniprotkb:Ubiquitin thioesterase 43(gene name synonym) psi-mi:magi3_human(display_long)|uniprotkb:MAGI3(gene name)|psi-mi:MAGI3(display_short)|uniprotkb:KIAA1634(gene name synonym)|uniprotkb:Membrane-associated guanylate kinase inverted 3(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512708|imex:IM-12079-75 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000154914(gene)|ensembl:ENST00000285199(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019785"(ISG15-specific protease activity)|go:"GO:0019985"(translesion synthesis)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|mint:Q70EL4|reactome:R-HSA-5656169|refseq:XP_011521944.1|refseq:NP_694942.3|refseq:NP_001254505.1|refseq:XP_016879649.1|refseq:XP_016879650.1 ensembl:ENST00000307546(transcript)|go:"GO:0004385"(guanylate kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005923"(bicellular tight junction)|ensembl:ENSG00000081026(gene)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0030054"(cell junction)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0016020"(membrane)|go:"GO:0060090"(molecular adaptor activity)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR020590|interpro:IPR027417|interpro:IPR030035|interpro:IPR036020|interpro:IPR036034|mint:Q5TCQ9|rcsb pdb:3SOE|refseq:NP_001136254.1|refseq:NP_690864.2|refseq:XP_005270794.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:+SANKIEEdBufqJU5XmrGbqXjnu09606 rogid:muK+zH3ww4Ve8aJ74iU2be8hRa09606 intact-crc:7C80EBD75A9B85C6|rigid:KRiY6Gn3ByurBLHNeUY6a8MFH44 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q70EL4 uniprotkb:Q9HA64 intact:EBI-2512700|ensembl:ENSP00000285199|uniprotkb:Q8N2C5|uniprotkb:A6NDT9|uniprotkb:Q96DQ6|uniprotkb:B7ZLT9|uniprotkb:B7ZVX5 intact:EBI-2512721|ensembl:ENSP00000269373|uniprotkb:Q969F4|uniprotkb:Q9H0U7 psi-mi:ubp43_human(display_long)|uniprotkb:USP43(gene name)|psi-mi:USP43(display_short)|uniprotkb:Ubiquitin-specific-processing protease 43(gene name synonym)|uniprotkb:Deubiquitinating enzyme 43(gene name synonym)|uniprotkb:Ubiquitin thioesterase 43(gene name synonym) psi-mi:kt3k_human(display_long)|uniprotkb:FN3KRP(gene name)|psi-mi:FN3KRP(display_short)|uniprotkb:Fructosamine-3-kinase-related protein(gene name synonym)|uniprotkb:Protein-psicosamine 3-kinase FN3KRP(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512708|imex:IM-12079-75 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000154914(gene)|ensembl:ENST00000285199(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019785"(ISG15-specific protease activity)|go:"GO:0019985"(translesion synthesis)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|mint:Q70EL4|reactome:R-HSA-5656169|refseq:XP_011521944.1|refseq:NP_694942.3|refseq:NP_001254505.1|refseq:XP_016879649.1|refseq:XP_016879650.1 ensembl:ENSG00000141560(gene)|ensembl:ENST00000269373(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0016301"(kinase activity)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0102193"(protein-ribulosamine 3-kinase activity)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016477(Ketosamine-3-kinase)|reactome:R-HSA-163841|refseq:NP_078895.2 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:+SANKIEEdBufqJU5XmrGbqXjnu09606 rogid:DbnUHyAgUcfytGqoYbFLv4Bwg7U9606 intact-crc:7C80EBD75A9B85C6|rigid:KRiY6Gn3ByurBLHNeUY6a8MFH44 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q70EL4 uniprotkb:Q04917 intact:EBI-2512700|ensembl:ENSP00000285199|uniprotkb:Q8N2C5|uniprotkb:A6NDT9|uniprotkb:Q96DQ6|uniprotkb:B7ZLT9|uniprotkb:B7ZVX5 intact:EBI-306940|ensembl:ENSP00000248975|intact:EBI-11759595 psi-mi:ubp43_human(display_long)|uniprotkb:USP43(gene name)|psi-mi:USP43(display_short)|uniprotkb:Ubiquitin-specific-processing protease 43(gene name synonym)|uniprotkb:Deubiquitinating enzyme 43(gene name synonym)|uniprotkb:Ubiquitin thioesterase 43(gene name synonym) psi-mi:1433f_human(display_long)|uniprotkb:YWHAH(gene name)|psi-mi:YWHAH(display_short)|uniprotkb:YWHA1(gene name synonym)|uniprotkb:Protein AS1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512708|imex:IM-12079-75 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000154914(gene)|ensembl:ENST00000285199(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019785"(ISG15-specific protease activity)|go:"GO:0019985"(translesion synthesis)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|mint:Q70EL4|reactome:R-HSA-5656169|refseq:XP_011521944.1|refseq:NP_694942.3|refseq:NP_001254505.1|refseq:XP_016879649.1|refseq:XP_016879650.1 go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0050774"(negative regulation of dendrite morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0086010"(membrane depolarization during action potential)|go:"GO:2000649"(regulation of sodium ion transmembrane transporter activity)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:Q04917|rcsb pdb:2C63|rcsb pdb:2C74|reactome:R-HSA-111447|reactome:R-HSA-1445148|reactome:R-HSA-5625740|reactome:R-HSA-5628897|reactome:R-HSA-75035|ensembl:ENSG00000128245(gene)|ensembl:ENST00000248975(transcript)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0003779"(actin binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006713"(glucocorticoid catabolic process)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0014704"(intercalated disc)|go:"GO:0017080"(sodium channel regulator activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021762"(substantia nigra development)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042921"(glucocorticoid receptor signaling pathway)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|refseq:NP_003396.1|dip:DIP-27566N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:+SANKIEEdBufqJU5XmrGbqXjnu09606 rogid:VhFYPSsW3IRC388FTlmwwN37HnU9606 intact-crc:7C80EBD75A9B85C6|rigid:KRiY6Gn3ByurBLHNeUY6a8MFH44 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q70EL4 uniprotkb:P61289 intact:EBI-2512700|ensembl:ENSP00000285199|uniprotkb:Q8N2C5|uniprotkb:A6NDT9|uniprotkb:Q96DQ6|uniprotkb:B7ZLT9|uniprotkb:B7ZVX5 intact:EBI-355546|uniprotkb:O35563|uniprotkb:P97373|uniprotkb:Q12920|uniprotkb:Q13172|uniprotkb:Q9BQD9|uniprotkb:A8K9A3|ensembl:ENSP00000466794 psi-mi:ubp43_human(display_long)|uniprotkb:USP43(gene name)|psi-mi:USP43(display_short)|uniprotkb:Ubiquitin-specific-processing protease 43(gene name synonym)|uniprotkb:Deubiquitinating enzyme 43(gene name synonym)|uniprotkb:Ubiquitin thioesterase 43(gene name synonym) psi-mi:psme3_human(display_long)|uniprotkb:PSME3(gene name)|psi-mi:PSME3(display_short)|uniprotkb:Proteasome activator 28 subunit gamma(gene name synonym)|uniprotkb:Activator of multicatalytic protease subunit 3(gene name synonym)|uniprotkb:11S regulator complex subunit gamma(gene name synonym)|uniprotkb:Ki nuclear autoantigen(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512708|imex:IM-12079-75 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000154914(gene)|ensembl:ENST00000285199(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019785"(ISG15-specific protease activity)|go:"GO:0019985"(translesion synthesis)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|mint:Q70EL4|reactome:R-HSA-5656169|refseq:XP_011521944.1|refseq:NP_694942.3|refseq:NP_001254505.1|refseq:XP_016879649.1|refseq:XP_016879650.1 refseq:NP_005780.2|refseq:NP_789839.1|ensembl:ENSG00000131467(gene)|ensembl:ENST00000590720(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0002039"(p53 binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0008537"(proteasome activator complex)|go:"GO:0010950"(positive regulation of endopeptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0061133"(endopeptidase activator activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR003185(Proteasome activator pa28, REG alpha subunit)|interpro:IPR003186(Proteasome activator pa28, REG beta subunit)|interpro:IPR009077(Proteasome activator pa28, REG alpha/beta subunit)|interpro:IPR036252|interpro:IPR036996|interpro:IPR036997|mint:P61289|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:+SANKIEEdBufqJU5XmrGbqXjnu09606 rogid:6EQY2Kj3Juf++m4eBDzPWMgbC2k9606 intact-crc:7C80EBD75A9B85C6|rigid:KRiY6Gn3ByurBLHNeUY6a8MFH44 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q70EL4 uniprotkb:Q9UNX4 intact:EBI-2512700|ensembl:ENSP00000285199|uniprotkb:Q8N2C5|uniprotkb:A6NDT9|uniprotkb:Q96DQ6|uniprotkb:B7ZLT9|uniprotkb:B7ZVX5 intact:EBI-727436|ensembl:ENSP00000308179 psi-mi:ubp43_human(display_long)|uniprotkb:USP43(gene name)|psi-mi:USP43(display_short)|uniprotkb:Ubiquitin-specific-processing protease 43(gene name synonym)|uniprotkb:Deubiquitinating enzyme 43(gene name synonym)|uniprotkb:Ubiquitin thioesterase 43(gene name synonym) psi-mi:wdr3_human(display_long)|uniprotkb:WDR3(gene name)|psi-mi:WDR3(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512708|imex:IM-12079-75 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000154914(gene)|ensembl:ENST00000285199(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019785"(ISG15-specific protease activity)|go:"GO:0019985"(translesion synthesis)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|mint:Q70EL4|reactome:R-HSA-5656169|refseq:XP_011521944.1|refseq:NP_694942.3|refseq:NP_001254505.1|refseq:XP_016879649.1|refseq:XP_016879650.1 refseq:NP_006775.1|ensembl:ENSG00000065183(gene)|ensembl:ENST00000349139(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0030490"(maturation of SSU-rRNA)|go:"GO:0030515"(snoRNA binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032040"(small-subunit processome)|go:"GO:0034388"(Pwp2p-containing subcomplex of 90S preribosome)|interpro:IPR001680(WD40 repeat)|interpro:IPR007148(Small-subunit processome, Utp12)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR024977|interpro:IPR036322|mint:Q9UNX4|reactome:R-HSA-6790901|reactome:R-HSA-6791226 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:+SANKIEEdBufqJU5XmrGbqXjnu09606 rogid:aslkTiEP+9ytaN6cc+SC+TzOxUg9606 intact-crc:7C80EBD75A9B85C6|rigid:KRiY6Gn3ByurBLHNeUY6a8MFH44 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q70EL4 uniprotkb:Q16342 intact:EBI-2512700|ensembl:ENSP00000285199|uniprotkb:Q8N2C5|uniprotkb:A6NDT9|uniprotkb:Q96DQ6|uniprotkb:B7ZLT9|uniprotkb:B7ZVX5 intact:EBI-359462|uniprotkb:Q9UH12|uniprotkb:E9PCU7|uniprotkb:F5GYS7|ensembl:ENSP00000439467|uniprotkb:Q58HM9|uniprotkb:Q58HN0 psi-mi:ubp43_human(display_long)|uniprotkb:USP43(gene name)|psi-mi:USP43(display_short)|uniprotkb:Ubiquitin-specific-processing protease 43(gene name synonym)|uniprotkb:Deubiquitinating enzyme 43(gene name synonym)|uniprotkb:Ubiquitin thioesterase 43(gene name synonym) psi-mi:pdcd2_human(display_long)|uniprotkb:PDCD2(gene name)|psi-mi:PDCD2(display_short)|uniprotkb:RP8(gene name synonym)|uniprotkb:ZMYND7(gene name synonym)|uniprotkb:Zinc finger protein Rp-8(gene name synonym)|uniprotkb:Zinc finger MYND domain-containing protein 7(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512708|imex:IM-12079-75 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000154914(gene)|ensembl:ENST00000285199(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019785"(ISG15-specific protease activity)|go:"GO:0019985"(translesion synthesis)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|mint:Q70EL4|reactome:R-HSA-5656169|refseq:XP_011521944.1|refseq:NP_694942.3|refseq:NP_001254505.1|refseq:XP_016879649.1|refseq:XP_016879650.1 refseq:NP_002589.2|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1901532"(regulation of hematopoietic progenitor cell differentiation)|go:"GO:1902035"(positive regulation of hematopoietic stem cell proliferation)|interpro:IPR002893(Zinc finger, MYND-type)|interpro:IPR007320(Programmed cell death protein 2, C-terminal)|mint:Q16342|ensembl:ENSG00000071994(gene)|ensembl:ENST00000541970(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0019899"(enzyme binding)|refseq:NP_001186392.1|refseq:NP_001186393.1|refseq:NP_001186391.1|refseq:NP_659005.1|dip:DIP-27594N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:+SANKIEEdBufqJU5XmrGbqXjnu09606 rogid:I44GXBUa4NByhkP4HQdnUgfkNCs9606 intact-crc:7C80EBD75A9B85C6|rigid:KRiY6Gn3ByurBLHNeUY6a8MFH44 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q70EL4 uniprotkb:Q96QK1 intact:EBI-2512700|ensembl:ENSP00000285199|uniprotkb:Q8N2C5|uniprotkb:A6NDT9|uniprotkb:Q96DQ6|uniprotkb:B7ZLT9|uniprotkb:B7ZVX5 intact:EBI-1054634|uniprotkb:Q561W2|uniprotkb:Q9H016|uniprotkb:Q9H096|uniprotkb:Q9H4P3|uniprotkb:Q9H8J0|uniprotkb:Q9NRS7|uniprotkb:Q9NVG2|uniprotkb:Q9NX80|uniprotkb:Q9NZK2|ensembl:ENSP00000299138 psi-mi:ubp43_human(display_long)|uniprotkb:USP43(gene name)|psi-mi:USP43(display_short)|uniprotkb:Ubiquitin-specific-processing protease 43(gene name synonym)|uniprotkb:Deubiquitinating enzyme 43(gene name synonym)|uniprotkb:Ubiquitin thioesterase 43(gene name synonym) psi-mi:vps35_human(display_long)|uniprotkb:Vesicle protein sorting 35(gene name synonym)|uniprotkb:Maternal-embryonic 3(gene name synonym)|uniprotkb:VPS35(gene name)|psi-mi:VPS35(display_short)|uniprotkb:MEM3(gene name synonym)|uniprotkb:TCCCTA00141(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512708|imex:IM-12079-75 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000154914(gene)|ensembl:ENST00000285199(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019785"(ISG15-specific protease activity)|go:"GO:0019985"(translesion synthesis)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|mint:Q70EL4|reactome:R-HSA-5656169|refseq:XP_011521944.1|refseq:NP_694942.3|refseq:NP_001254505.1|refseq:XP_016879649.1|refseq:XP_016879650.1 refseq:NP_060676.2|rcsb pdb:5F0J|rcsb pdb:5F0K|rcsb pdb:5F0L|rcsb pdb:5F0M|rcsb pdb:5F0P|rcsb pdb:5OSH|rcsb pdb:5OSI|rcsb pdb:7BLN|rcsb pdb:7BLO|reactome:R-HSA-3238698|ensembl:ENSG00000069329(gene)|ensembl:ENST00000299138(transcript)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0010008"(endosome membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0030904"(retromer complex)|go:"GO:0030906"(retromer, cargo-selective complex)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0032268"(regulation of cellular protein metabolic process)|go:"GO:0032456"(endocytic recycling)|go:"GO:0036010"(protein localization to endosome)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0043653"(mitochondrial fragmentation involved in apoptotic process)|go:"GO:0045056"(transcytosis)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0060161"(positive regulation of dopamine receptor signaling pathway)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0097422"(tubular endosome)|go:"GO:0099073"(mitochondrion-derived vesicle)|go:"GO:0099074"(mitochondrion to lysosome transport)|go:"GO:0099639"(neurotransmitter receptor transport, endosome to plasma membrane)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902823"(negative regulation of late endosome to lysosome transport)|go:"GO:1902950"(regulation of dendritic spine maintenance)|go:"GO:1903364"(positive regulation of cellular protein catabolic process)|go:"GO:1905606"(regulation of presynapse assembly)|go:"GO:2000331"(regulation of terminal button organization)|interpro:IPR005378(Vacuolar protein sorting-associated protein 35)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR042491|rcsb pdb:2R17|dip:DIP-29076N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:+SANKIEEdBufqJU5XmrGbqXjnu09606 rogid:EXkMduDQKNCdp876vGF5vna9t389606 intact-crc:7C80EBD75A9B85C6|rigid:KRiY6Gn3ByurBLHNeUY6a8MFH44 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q70EL4 uniprotkb:P62258 intact:EBI-2512700|ensembl:ENSP00000285199|uniprotkb:Q8N2C5|uniprotkb:A6NDT9|uniprotkb:Q96DQ6|uniprotkb:B7ZLT9|uniprotkb:B7ZVX5 intact:EBI-356498|uniprotkb:P29360|uniprotkb:P42655|uniprotkb:Q53XZ5|uniprotkb:Q63631|uniprotkb:Q7M4R4|uniprotkb:B3KY71|uniprotkb:D3DTH5|uniprotkb:Q4VJB6|ensembl:ENSP00000264335|ensembl:ENSP00000487356 psi-mi:ubp43_human(display_long)|uniprotkb:USP43(gene name)|psi-mi:USP43(display_short)|uniprotkb:Ubiquitin-specific-processing protease 43(gene name synonym)|uniprotkb:Deubiquitinating enzyme 43(gene name synonym)|uniprotkb:Ubiquitin thioesterase 43(gene name synonym) psi-mi:1433e_human(display_long)|uniprotkb:YWHAE(gene name)|psi-mi:YWHAE(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512708|imex:IM-12079-75 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000154914(gene)|ensembl:ENST00000285199(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019785"(ISG15-specific protease activity)|go:"GO:0019985"(translesion synthesis)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|mint:Q70EL4|reactome:R-HSA-5656169|refseq:XP_011521944.1|refseq:NP_694942.3|refseq:NP_001254505.1|refseq:XP_016879649.1|refseq:XP_016879650.1 refseq:NP_006752.1|dip:DIP-36676N|reactome:R-HSA-1445148|reactome:R-HSA-2028269|reactome:R-HSA-205025|reactome:R-HSA-2565942|reactome:R-HSA-3371453|reactome:R-HSA-3371511|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-5625740|reactome:R-HSA-5628897|reactome:R-HSA-75035|reactome:R-HSA-8854518|reactome:R-HSA-8862803|reactome:R-HSA-8876198|ensembl:ENSG00000108953(gene)|ensembl:ENSG00000274474(gene)|ensembl:ENST00000264335(transcript)|ensembl:ENST00000627231(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0003064"(regulation of heart rate by hormone)|go:"GO:0003723"(RNA binding)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005871"(kinesin complex)|go:"GO:0005925"(focal adhesion)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0021762"(substantia nigra development)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0060306"(regulation of membrane repolarization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0086013"(membrane repolarization during cardiac muscle cell action potential)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0090724"(central region of growth cone)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099072"(regulation of postsynaptic membrane neurotransmitter receptor levels)|go:"GO:1901016"(regulation of potassium ion transmembrane transporter activity)|go:"GO:1901020"(negative regulation of calcium ion transmembrane transporter activity)|go:"GO:1902309"(negative regulation of peptidyl-serine dephosphorylation)|go:"GO:1905913"(negative regulation of calcium ion export across plasma membrane)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:P62258|rcsb pdb:2BR9|rcsb pdb:3UAL|rcsb pdb:3UBW|rcsb pdb:6EIH|rcsb pdb:7C8E|reactome:R-HSA-111447 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:+SANKIEEdBufqJU5XmrGbqXjnu09606 rogid:mnuAjdnQZbMFojll2PnV3xFklXQ9606 intact-crc:7C80EBD75A9B85C6|rigid:KRiY6Gn3ByurBLHNeUY6a8MFH44 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q70EL4 uniprotkb:P31946 intact:EBI-2512700|ensembl:ENSP00000285199|uniprotkb:Q8N2C5|uniprotkb:A6NDT9|uniprotkb:Q96DQ6|uniprotkb:B7ZLT9|uniprotkb:B7ZVX5 intact:EBI-359815|uniprotkb:A8K9K2|uniprotkb:E1P616|ensembl:ENSP00000300161|ensembl:ENSP00000361930 psi-mi:ubp43_human(display_long)|uniprotkb:USP43(gene name)|psi-mi:USP43(display_short)|uniprotkb:Ubiquitin-specific-processing protease 43(gene name synonym)|uniprotkb:Deubiquitinating enzyme 43(gene name synonym)|uniprotkb:Ubiquitin thioesterase 43(gene name synonym) psi-mi:1433b_human(display_long)|uniprotkb:YWHAB(gene name)|psi-mi:YWHAB(display_short)|uniprotkb:Protein kinase C inhibitor protein 1(gene name synonym)|uniprotkb:Protein 1054(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512708|imex:IM-12079-75 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000154914(gene)|ensembl:ENST00000285199(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019785"(ISG15-specific protease activity)|go:"GO:0019985"(translesion synthesis)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|mint:Q70EL4|reactome:R-HSA-5656169|refseq:XP_011521944.1|refseq:NP_694942.3|refseq:NP_001254505.1|refseq:XP_016879649.1|refseq:XP_016879650.1 refseq:NP_003395.1|refseq:NP_647539.1|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051220"(cytoplasmic sequestering of protein)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:P31946|rcsb pdb:2BQ0|rcsb pdb:2C23|rcsb pdb:4DNK|rcsb pdb:5N10|rcsb pdb:6A5Q|rcsb pdb:6BYK|rcsb pdb:6GN0|rcsb pdb:6GN8|rcsb pdb:6GNJ|rcsb pdb:6GNK|rcsb pdb:6GNN|rcsb pdb:6HEP|reactome:R-HSA-111447|reactome:R-HSA-1445148|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-170968|reactome:R-HSA-170984|reactome:R-HSA-2028269|reactome:R-HSA-392517|reactome:R-HSA-450385|reactome:R-HSA-450513|reactome:R-HSA-5625740|reactome:R-HSA-5628897|reactome:R-HSA-5673000|reactome:R-HSA-5674135|reactome:R-HSA-5675221|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-75035|reactome:R-HSA-9614399|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9660537|ensembl:ENSG00000166913(gene)|ensembl:ENST00000353703(transcript)|ensembl:ENST00000372839(transcript)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005774"(vacuolar membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006605"(protein targeting)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0016020"(membrane)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|refseq:XP_016883528.1|dip:DIP-743N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:+SANKIEEdBufqJU5XmrGbqXjnu09606 rogid:rp43CodPzsPadWEPtbnpKFAVIIU9606 intact-crc:7C80EBD75A9B85C6|rigid:KRiY6Gn3ByurBLHNeUY6a8MFH44 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P62068 uniprotkb:Q9P2K8 intact:EBI-2512753|ensembl:ENSP00000407818|uniprotkb:B7Z675|uniprotkb:Q9H7U4|uniprotkb:B7Z7S3|uniprotkb:B7Z3Y7|uniprotkb:Q80V95|uniprotkb:Q9H9T8|uniprotkb:G8ACC7 intact:EBI-746616|uniprotkb:Q69YL7|uniprotkb:Q6DC97|uniprotkb:Q96GN6|uniprotkb:Q9H5K1|uniprotkb:Q9NSQ3|uniprotkb:Q9NSZ5|uniprotkb:Q9UJ56|uniprotkb:C9JEC4|ensembl:ENSP00000263791 psi-mi:ubp46_human(display_long)|uniprotkb:USP46(gene name)|psi-mi:USP46(display_short)|uniprotkb:Ubiquitin-specific-processing protease 46(gene name synonym)|uniprotkb:Deubiquitinating enzyme 46(gene name synonym)|uniprotkb:Ubiquitin thioesterase 46(gene name synonym) psi-mi:e2ak4_human(display_long)|uniprotkb:GCN2-like protein(gene name synonym)|uniprotkb:EIF2AK4(gene name)|psi-mi:EIF2AK4(display_short)|uniprotkb:GCN2(gene name synonym)|uniprotkb:KIAA1338(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 2-alpha kinase 4(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512751|imex:IM-12079-25 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000109189(gene)|ensembl:ENST00000441222(transcript)|go:"GO:0001662"(behavioral fear response)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008343"(adult feeding behavior)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0032228"(regulation of synaptic transmission, GABAergic)|go:"GO:0046872"(metal ion binding)|go:"GO:0048149"(behavioral response to ethanol)|go:"GO:0060013"(righting reflex)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|mint:P62068|rcsb pdb:5CVM|rcsb pdb:5CVN|rcsb pdb:5CVO|rcsb pdb:5L8H|rcsb pdb:6JLQ|refseq:NP_001273696.1|refseq:NP_001273697.1|refseq:NP_001127695.1|refseq:NP_073743.2|dip:DIP-53590N refseq:NP_001013725.2|ensembl:ENSG00000128829(gene)|ensembl:ENST00000263791(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002286"(T cell activation involved in immune response)|go:"GO:0002821"(positive regulation of adaptive immune response)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004694"(eukaryotic translation initiation factor 2alpha kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0036492"(eiF2alpha phosphorylation in response to endoplasmic reticulum stress)|go:"GO:0039520"(induction by virus of host autophagy)|go:"GO:0044828"(negative regulation by host of viral genome replication)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0051607"(defense response to virus)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0070417"(cellular response to cold)|go:"GO:0071264"(positive regulation of translational initiation in response to starvation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0140469"(GCN2-mediated signaling)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1990138"(neuron projection extension)|go:"GO:1990253"(cellular response to leucine starvation)|interpro:IPR000719(Protein kinase, core)|go:"GO:0007612"(learning)|go:"GO:0007616"(long-term memory)|go:"GO:0010998"(regulation of translational initiation by eIF2 alpha phosphorylation)|go:"GO:0019081"(viral translation)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0032057"(negative regulation of translational initiation in response to stress)|go:"GO:0032792"(negative regulation of CREB transcription factor activity)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034644"(cellular response to UV)|interpro:IPR006575(RWD)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR016255(Serine/threonine-protein kinase, GCN2)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR024435|interpro:IPR036621|interpro:IPR041715|rcsb pdb:6N3L|rcsb pdb:6N3N|rcsb pdb:6N3O|rcsb pdb:7E2K|rcsb pdb:7E2M|reactome:R-HSA-9633012 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/05/28 rogid:MYmLwHkGXhvq+vVvr88amlicCbg9606 rogid:rPY2wmZ1ol512887sv3BEZeagcE9606 intact-crc:CDFAB9C4F7F44209|rigid:HJzSDg64i08arW1bmTNoyDj6WW0 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P62068 uniprotkb:P49189 intact:EBI-2512753|ensembl:ENSP00000407818|uniprotkb:B7Z675|uniprotkb:Q9H7U4|uniprotkb:B7Z7S3|uniprotkb:B7Z3Y7|uniprotkb:Q80V95|uniprotkb:Q9H9T8|uniprotkb:G8ACC7 intact:EBI-1055313|uniprotkb:B2R6X1|uniprotkb:Q6LCL1|uniprotkb:Q9NZT7|uniprotkb:Q5VV90|uniprotkb:B4DXY7|uniprotkb:B9EKV4 psi-mi:ubp46_human(display_long)|uniprotkb:USP46(gene name)|psi-mi:USP46(display_short)|uniprotkb:Ubiquitin-specific-processing protease 46(gene name synonym)|uniprotkb:Deubiquitinating enzyme 46(gene name synonym)|uniprotkb:Ubiquitin thioesterase 46(gene name synonym) psi-mi:al9a1_human(display_long)|uniprotkb:Aldehyde dehydrogenase family 9 member A1(gene name synonym)|uniprotkb:Aldehyde dehydrogenase E3 isozyme(gene name synonym)|uniprotkb:Gamma-aminobutyraldehyde dehydrogenase(gene name synonym)|uniprotkb:R-aminobutyraldehyde dehydrogenase(gene name synonym)|uniprotkb:ALDH9A1(gene name)|psi-mi:ALDH9A1(display_short)|uniprotkb:ALDH7(gene name synonym)|uniprotkb:ALDH9(gene name synonym)|uniprotkb:ALDH4(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512751|imex:IM-12079-25 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000109189(gene)|ensembl:ENST00000441222(transcript)|go:"GO:0001662"(behavioral fear response)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008343"(adult feeding behavior)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0032228"(regulation of synaptic transmission, GABAergic)|go:"GO:0046872"(metal ion binding)|go:"GO:0048149"(behavioral response to ethanol)|go:"GO:0060013"(righting reflex)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|mint:P62068|rcsb pdb:5CVM|rcsb pdb:5CVN|rcsb pdb:5CVO|rcsb pdb:5L8H|rcsb pdb:6JLQ|refseq:NP_001273696.1|refseq:NP_001273697.1|refseq:NP_001127695.1|refseq:NP_073743.2|dip:DIP-53590N refseq:NP_000687.3|interpro:IPR016161(Aldehyde/histidinol dehydrogenase)|interpro:IPR016160(Aldehyde dehydrogenase, conserved site)|interpro:IPR016162(Aldehyde dehydrogenase, N-terminal)|interpro:IPR015590(Aldehyde dehydrogenase)|refseq:XP_011507596.1|interpro:IPR029510|go:"GO:0004029"("aldehyde dehydrogenase (NAD+) activity")|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006081"(cellular aldehyde metabolic process)|go:"GO:0019145"(aminobutyraldehyde dehydrogenase activity)|go:"GO:0033737"(1-pyrroline dehydrogenase activity)|go:"GO:0042136"(neurotransmitter biosynthetic process)|go:"GO:0042445"(hormone metabolic process)|go:"GO:0043878"("glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity")|go:"GO:0045329"(carnitine biosynthetic process)|go:"GO:0047105"(4-trimethylammoniobutyraldehyde dehydrogenase activity)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0070062"(extracellular exosome)|rcsb pdb:6QAK|rcsb pdb:6QAO|rcsb pdb:6QAP|rcsb pdb:6VR6|rcsb pdb:6VWF|reactome:R-HSA-71262|interpro:IPR016163(Aldehyde dehydrogenase, C-terminal)|mint:P49189 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/05/28 rogid:MYmLwHkGXhvq+vVvr88amlicCbg9606 rogid:MYde00UETppWGSEKa35Jsck7Joc9606 intact-crc:CDFAB9C4F7F44209|rigid:HJzSDg64i08arW1bmTNoyDj6WW0 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P62068 uniprotkb:Q96SB3 intact:EBI-2512753|ensembl:ENSP00000407818|uniprotkb:B7Z675|uniprotkb:Q9H7U4|uniprotkb:B7Z7S3|uniprotkb:B7Z3Y7|uniprotkb:Q80V95|uniprotkb:Q9H9T8|uniprotkb:G8ACC7 intact:EBI-351275|uniprotkb:Q8TCR9|intact:EBI-28984643|ensembl:ENSP00000478767|intact:EBI-4401886|uniprotkb:D3DTX6 psi-mi:ubp46_human(display_long)|uniprotkb:USP46(gene name)|psi-mi:USP46(display_short)|uniprotkb:Ubiquitin-specific-processing protease 46(gene name synonym)|uniprotkb:Deubiquitinating enzyme 46(gene name synonym)|uniprotkb:Ubiquitin thioesterase 46(gene name synonym) psi-mi:neb2_human(display_long)|uniprotkb:Neurabin-II(gene name synonym)|uniprotkb:Spinophilin(gene name synonym)|uniprotkb:Protein phosphatase 1 regulatory subunit 9B(gene name synonym)|uniprotkb:PPP1R9B(gene name)|psi-mi:PPP1R9B(display_short)|uniprotkb:PPP1R6(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512751|imex:IM-12079-25 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000109189(gene)|ensembl:ENST00000441222(transcript)|go:"GO:0001662"(behavioral fear response)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008343"(adult feeding behavior)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0032228"(regulation of synaptic transmission, GABAergic)|go:"GO:0046872"(metal ion binding)|go:"GO:0048149"(behavioral response to ethanol)|go:"GO:0060013"(righting reflex)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|mint:P62068|rcsb pdb:5CVM|rcsb pdb:5CVN|rcsb pdb:5CVO|rcsb pdb:5L8H|rcsb pdb:6JLQ|refseq:NP_001273696.1|refseq:NP_001273697.1|refseq:NP_001127695.1|refseq:NP_073743.2|dip:DIP-53590N ensembl:ENSG00000108819(gene)|ensembl:ENST00000612501(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0001560"(regulation of cell growth by extracellular stimulus)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001975"(response to amphetamine)|go:"GO:0003006"(developmental process involved in reproduction)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004864"(protein phosphatase inhibitor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007015"(actin filament organization)|go:"GO:0007096"(regulation of exit from mitosis)|go:"GO:0007568"(aging)|go:"GO:0007612"(learning)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0008380"(RNA splicing)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016358"(dendrite development)|go:"GO:0016477"(cell migration)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019900"(kinase binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030042"(actin filament depolymerization)|go:"GO:0030175"(filopodium)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031175"(neuron projection development)|go:"GO:0031749"(D2 dopamine receptor binding)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032587"(ruffle membrane)|go:"GO:0034695"(response to prostaglandin E)|go:"GO:0035094"(response to nicotine)|go:"GO:0035690"|go:"GO:0035902"(response to immobilization stress)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0046847"(filopodium assembly)|go:"GO:0048545"(response to steroid hormone)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051015"(actin filament binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060179"(male mating behavior)|go:"GO:0061458"(reproductive system development)|go:"GO:0071315"(cellular response to morphine)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0097338"(response to clozapine)|go:"GO:1901653"(cellular response to peptide)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903119"(protein localization to actin cytoskeleton)|go:"GO:1904372"(positive regulation of protein localization to actin cortical patch)|go:"GO:1904373"(response to kainic acid)|go:"GO:1904386"(response to L-phenylalanine derivative)|go:"GO:1990778"(protein localization to cell periphery)|go:"GO:1990780"(cytoplasmic side of dendritic spine plasma membrane)|go:"GO:2000474"(regulation of opioid receptor signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR029921|interpro:IPR036034|interpro:IPR040645|interpro:IPR043446|mint:Q96SB3|ensembl:ENSP00000478767|refseq:NP_115984.3 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/05/28 rogid:MYmLwHkGXhvq+vVvr88amlicCbg9606 rogid:X6fQLpaYhXCqzRlQNEoX67P/HbU9606 intact-crc:CDFAB9C4F7F44209|rigid:HJzSDg64i08arW1bmTNoyDj6WW0 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P62068 uniprotkb:Q96B01 intact:EBI-2512753|ensembl:ENSP00000407818|uniprotkb:B7Z675|uniprotkb:Q9H7U4|uniprotkb:B7Z7S3|uniprotkb:B7Z3Y7|uniprotkb:Q80V95|uniprotkb:Q9H9T8|uniprotkb:G8ACC7 intact:EBI-1178724|uniprotkb:O43403|uniprotkb:Q7Z779|uniprotkb:A8K7D3|ensembl:ENSP00000228843 psi-mi:ubp46_human(display_long)|uniprotkb:USP46(gene name)|psi-mi:USP46(display_short)|uniprotkb:Ubiquitin-specific-processing protease 46(gene name synonym)|uniprotkb:Deubiquitinating enzyme 46(gene name synonym)|uniprotkb:Ubiquitin thioesterase 46(gene name synonym) psi-mi:r51a1_human(display_long)|uniprotkb:RAD51-interacting protein(gene name synonym)|uniprotkb:RAD51AP1(gene name)|psi-mi:RAD51AP1(display_short)|uniprotkb:PIR51(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512751|imex:IM-12079-25 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000109189(gene)|ensembl:ENST00000441222(transcript)|go:"GO:0001662"(behavioral fear response)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008343"(adult feeding behavior)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0032228"(regulation of synaptic transmission, GABAergic)|go:"GO:0046872"(metal ion binding)|go:"GO:0048149"(behavioral response to ethanol)|go:"GO:0060013"(righting reflex)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|mint:P62068|rcsb pdb:5CVM|rcsb pdb:5CVN|rcsb pdb:5CVO|rcsb pdb:5L8H|rcsb pdb:6JLQ|refseq:NP_001273696.1|refseq:NP_001273697.1|refseq:NP_001127695.1|refseq:NP_073743.2|dip:DIP-53590N refseq:NP_001124334.1|refseq:NP_006470.1|ensembl:ENSG00000111247(gene)|ensembl:ENST00000228843(transcript)|go:"GO:0000217"(DNA secondary structure binding)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010569"(regulation of double-strand break repair via homologous recombination)|go:"GO:0010845"(positive regulation of reciprocal meiotic recombination)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0062037"(D-loop DNA binding)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|interpro:IPR026632|interpro:IPR031419|reactome:R-HSA-5685942|reactome:R-HSA-5693554|reactome:R-HSA-5693568|reactome:R-HSA-5693579|dip:DIP-35257N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/05/28 rogid:MYmLwHkGXhvq+vVvr88amlicCbg9606 rogid:5f/zzkdZZSmaPFxkg52s60rDnqQ9606 intact-crc:CDFAB9C4F7F44209|rigid:HJzSDg64i08arW1bmTNoyDj6WW0 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P62068 uniprotkb:P14649 intact:EBI-2512753|ensembl:ENSP00000407818|uniprotkb:B7Z675|uniprotkb:Q9H7U4|uniprotkb:B7Z7S3|uniprotkb:B7Z3Y7|uniprotkb:Q80V95|uniprotkb:Q9H9T8|uniprotkb:G8ACC7 intact:EBI-358570|ensembl:ENSP00000446643|ensembl:ENSP00000450385 psi-mi:ubp46_human(display_long)|uniprotkb:USP46(gene name)|psi-mi:USP46(display_short)|uniprotkb:Ubiquitin-specific-processing protease 46(gene name synonym)|uniprotkb:Deubiquitinating enzyme 46(gene name synonym)|uniprotkb:Ubiquitin thioesterase 46(gene name synonym) psi-mi:myl6b_human(display_long)|uniprotkb:MYL6B(gene name)|psi-mi:MYL6B(display_short)|uniprotkb:MLC1SA(gene name synonym)|uniprotkb:Smooth muscle and nonmuscle myosin light chain alkali 6B(gene name synonym)|uniprotkb:Myosin light chain 1 slow-twitch muscle A isoform(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512751|imex:IM-12079-25 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000109189(gene)|ensembl:ENST00000441222(transcript)|go:"GO:0001662"(behavioral fear response)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008343"(adult feeding behavior)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0032228"(regulation of synaptic transmission, GABAergic)|go:"GO:0046872"(metal ion binding)|go:"GO:0048149"(behavioral response to ethanol)|go:"GO:0060013"(righting reflex)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|mint:P62068|rcsb pdb:5CVM|rcsb pdb:5CVN|rcsb pdb:5CVO|rcsb pdb:5L8H|rcsb pdb:6JLQ|refseq:NP_001273696.1|refseq:NP_001273697.1|refseq:NP_001127695.1|refseq:NP_073743.2|dip:DIP-53590N refseq:NP_001186558.1|refseq:NP_002466.1|ensembl:ENSG00000196465(gene)|ensembl:ENST00000550443(transcript)|ensembl:ENST00000553066(transcript)|go:"GO:0003774"(cytoskeletal motor activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005829"(cytosol)|go:"GO:0005859"(muscle myosin complex)|go:"GO:0006936"(muscle contraction)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0008307"(structural constituent of muscle)|go:"GO:0016459"(myosin complex)|go:"GO:0016461"(unconventional myosin complex)|go:"GO:0030049"(muscle filament sliding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|rcsb pdb:1OE9|rcsb pdb:1W7I|rcsb pdb:1W7J|reactome:R-HSA-445355 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/05/28 rogid:MYmLwHkGXhvq+vVvr88amlicCbg9606 rogid:S0/S5hUxfyyve1JDMojIggOSBb89606 intact-crc:CDFAB9C4F7F44209|rigid:HJzSDg64i08arW1bmTNoyDj6WW0 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P62068 uniprotkb:Q6ZVD8 intact:EBI-2512753|ensembl:ENSP00000407818|uniprotkb:B7Z675|uniprotkb:Q9H7U4|uniprotkb:B7Z7S3|uniprotkb:B7Z3Y7|uniprotkb:Q80V95|uniprotkb:Q9H9T8|uniprotkb:G8ACC7 intact:EBI-2511496|uniprotkb:Q9NV17|uniprotkb:Q9Y2E3|uniprotkb:A1L374|ensembl:ENSP00000457991 psi-mi:ubp46_human(display_long)|uniprotkb:USP46(gene name)|psi-mi:USP46(display_short)|uniprotkb:Ubiquitin-specific-processing protease 46(gene name synonym)|uniprotkb:Deubiquitinating enzyme 46(gene name synonym)|uniprotkb:Ubiquitin thioesterase 46(gene name synonym) psi-mi:phlp2_human(display_long)|uniprotkb:PHLPP2(gene name)|psi-mi:PHLPP2(display_short)|uniprotkb:KIAA0931(gene name synonym)|uniprotkb:PHLPPL(gene name synonym)|uniprotkb:PH domain leucine-rich repeat-containing protein phosphatase-like(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512751|imex:IM-12079-25 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000109189(gene)|ensembl:ENST00000441222(transcript)|go:"GO:0001662"(behavioral fear response)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008343"(adult feeding behavior)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0032228"(regulation of synaptic transmission, GABAergic)|go:"GO:0046872"(metal ion binding)|go:"GO:0048149"(behavioral response to ethanol)|go:"GO:0060013"(righting reflex)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|mint:P62068|rcsb pdb:5CVM|rcsb pdb:5CVN|rcsb pdb:5CVO|rcsb pdb:5L8H|rcsb pdb:6JLQ|refseq:NP_001273696.1|refseq:NP_001273697.1|refseq:NP_001127695.1|refseq:NP_073743.2|dip:DIP-53590N refseq:NP_001275932.1|refseq:NP_055835.2|dip:DIP-53556N|ensembl:ENSG00000040199(gene)|ensembl:ENST00000568954(transcript)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0021766"(hippocampus development)|go:"GO:0042622"(photoreceptor outer segment membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045171"(intercellular bridge)|go:"GO:0046872"(metal ion binding)|go:"GO:0072686"(mitotic spindle)|go:"GO:0106306"|go:"GO:0106307"|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR001932(Protein phosphatase 2C-related)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR032675|interpro:IPR036457|reactome:R-HSA-199418 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/05/28 rogid:MYmLwHkGXhvq+vVvr88amlicCbg9606 rogid:Z6e8RRJ8TleJRWTlecN3DNu1Ums9606 intact-crc:CDFAB9C4F7F44209|rigid:HJzSDg64i08arW1bmTNoyDj6WW0 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P62068 uniprotkb:O60346 intact:EBI-2512753|ensembl:ENSP00000407818|uniprotkb:B7Z675|uniprotkb:Q9H7U4|uniprotkb:B7Z7S3|uniprotkb:B7Z3Y7|uniprotkb:Q80V95|uniprotkb:Q9H9T8|uniprotkb:G8ACC7 intact:EBI-2511516|intact:EBI-28974360|ensembl:ENSP00000262719|uniprotkb:Q6PJI6|uniprotkb:Q6P4C4|uniprotkb:A1A4F5|uniprotkb:Q641Q7|uniprotkb:Q86TN6|uniprotkb:Q96FK2|uniprotkb:Q9NUY1 psi-mi:ubp46_human(display_long)|uniprotkb:USP46(gene name)|psi-mi:USP46(display_short)|uniprotkb:Ubiquitin-specific-processing protease 46(gene name synonym)|uniprotkb:Deubiquitinating enzyme 46(gene name synonym)|uniprotkb:Ubiquitin thioesterase 46(gene name synonym) psi-mi:phlp1_human(display_long)|uniprotkb:PHLPP1(gene name)|psi-mi:PHLPP1(display_short)|uniprotkb:KIAA0606(gene name synonym)|uniprotkb:PHLPP(gene name synonym)|uniprotkb:PLEKHE1(gene name synonym)|uniprotkb:SCOP(gene name synonym)|uniprotkb:Pleckstrin homology domain-containing family E member 1(gene name synonym)|uniprotkb:Suprachiasmatic nucleus circadian oscillatory protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512751|imex:IM-12079-25 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000109189(gene)|ensembl:ENST00000441222(transcript)|go:"GO:0001662"(behavioral fear response)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008343"(adult feeding behavior)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0032228"(regulation of synaptic transmission, GABAergic)|go:"GO:0046872"(metal ion binding)|go:"GO:0048149"(behavioral response to ethanol)|go:"GO:0060013"(righting reflex)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|mint:P62068|rcsb pdb:5CVM|rcsb pdb:5CVN|rcsb pdb:5CVO|rcsb pdb:5L8H|rcsb pdb:6JLQ|refseq:NP_001273696.1|refseq:NP_001273697.1|refseq:NP_001127695.1|refseq:NP_073743.2|dip:DIP-53590N ensembl:ENSP00000262719|go:"GO:0009649"(entrainment of circadian clock)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046872"(metal ion binding)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1900744"(regulation of p38MAPK cascade)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001932(Protein phosphatase 2C-related)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR032675|interpro:IPR036457|mint:O60346|reactome:R-HSA-199418|ensembl:ENSG00000081913(gene)|ensembl:ENST00000262719(transcript)|go:"GO:0002667"(regulation of T cell anergy)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|refseq:NP_919431.2 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/05/28 rogid:MYmLwHkGXhvq+vVvr88amlicCbg9606 rogid:hPGjeSVMlJhO3o9YBWoBm9xppfk9606 intact-crc:CDFAB9C4F7F44209|rigid:HJzSDg64i08arW1bmTNoyDj6WW0 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P62068 uniprotkb:Q9P1S2 intact:EBI-2512753|ensembl:ENSP00000407818|uniprotkb:B7Z675|uniprotkb:Q9H7U4|uniprotkb:B7Z7S3|uniprotkb:B7Z3Y7|uniprotkb:Q80V95|uniprotkb:Q9H9T8|uniprotkb:G8ACC7 intact:EBI-2511504 psi-mi:ubp46_human(display_long)|uniprotkb:USP46(gene name)|psi-mi:USP46(display_short)|uniprotkb:Ubiquitin-specific-processing protease 46(gene name synonym)|uniprotkb:Deubiquitinating enzyme 46(gene name synonym)|uniprotkb:Ubiquitin thioesterase 46(gene name synonym) psi-mi:q9p1s2_human(display_long) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512751|imex:IM-12079-25 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000109189(gene)|ensembl:ENST00000441222(transcript)|go:"GO:0001662"(behavioral fear response)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008343"(adult feeding behavior)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0032228"(regulation of synaptic transmission, GABAergic)|go:"GO:0046872"(metal ion binding)|go:"GO:0048149"(behavioral response to ethanol)|go:"GO:0060013"(righting reflex)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|mint:P62068|rcsb pdb:5CVM|rcsb pdb:5CVN|rcsb pdb:5CVO|rcsb pdb:5L8H|rcsb pdb:6JLQ|refseq:NP_001273696.1|refseq:NP_001273697.1|refseq:NP_001127695.1|refseq:NP_073743.2|dip:DIP-53590N go:"GO:0051087"(chaperone binding)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR044563 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/05/28 rogid:MYmLwHkGXhvq+vVvr88amlicCbg9606 rogid:+pC1prCcP9i/pilHXx1M2iZRojs9606 intact-crc:CDFAB9C4F7F44209|rigid:HJzSDg64i08arW1bmTNoyDj6WW0 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P62068 uniprotkb:Q8TAF3 intact:EBI-2512753|ensembl:ENSP00000407818|uniprotkb:B7Z675|uniprotkb:Q9H7U4|uniprotkb:B7Z7S3|uniprotkb:B7Z3Y7|uniprotkb:Q80V95|uniprotkb:Q9H9T8|uniprotkb:G8ACC7 intact:EBI-1045469|uniprotkb:Q63HJ2|uniprotkb:Q658Y1|uniprotkb:Q8N3Z1|uniprotkb:Q9NSK8|uniprotkb:Q9P279|uniprotkb:B4DM86|uniprotkb:B4DQI2|uniprotkb:B4DY84|ensembl:ENSP00000307491 psi-mi:ubp46_human(display_long)|uniprotkb:USP46(gene name)|psi-mi:USP46(display_short)|uniprotkb:Ubiquitin-specific-processing protease 46(gene name synonym)|uniprotkb:Deubiquitinating enzyme 46(gene name synonym)|uniprotkb:Ubiquitin thioesterase 46(gene name synonym) psi-mi:wdr48_human(display_long)|uniprotkb:WD repeat endosomal protein(gene name synonym)|uniprotkb:p80(gene name synonym)|uniprotkb:WDR48(gene name)|psi-mi:WDR48(display_short)|uniprotkb:KIAA1449(gene name synonym)|uniprotkb:UAF1(gene name synonym)|uniprotkb:USP1-associated factor 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512751|imex:IM-12079-25 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000109189(gene)|ensembl:ENST00000441222(transcript)|go:"GO:0001662"(behavioral fear response)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008343"(adult feeding behavior)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0032228"(regulation of synaptic transmission, GABAergic)|go:"GO:0046872"(metal ion binding)|go:"GO:0048149"(behavioral response to ethanol)|go:"GO:0060013"(righting reflex)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|mint:P62068|rcsb pdb:5CVM|rcsb pdb:5CVN|rcsb pdb:5CVO|rcsb pdb:5L8H|rcsb pdb:6JLQ|refseq:NP_001273696.1|refseq:NP_001273697.1|refseq:NP_001127695.1|refseq:NP_073743.2|dip:DIP-53590N refseq:NP_065890.1|ensembl:ENSG00000114742(gene)|ensembl:ENST00000302313(transcript)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0003677"(DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043588"(skin development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0072520"(seminiferous tubule development)|go:"GO:1902525"(regulation of protein monoubiquitination)|go:"GO:1903003"(positive regulation of protein deubiquitination)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR021772|interpro:IPR036322|mint:Q8TAF3|rcsb pdb:5CVL|rcsb pdb:5CVN|rcsb pdb:5CVO|rcsb pdb:5K1A|rcsb pdb:5K1B|rcsb pdb:5K1C|rcsb pdb:5L8E|rcsb pdb:5L8W|rcsb pdb:6JLQ|rcsb pdb:7AY0|rcsb pdb:7AY1|rcsb pdb:7AY2|reactome:R-HSA-110314|reactome:R-HSA-5689880|reactome:R-HSA-6783310|reactome:R-HSA-9673766|refseq:NP_001290331.1|refseq:NP_001290332.1|refseq:NP_001333156.1|refseq:NP_001333157.1|dip:DIP-50841N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/05/28 rogid:MYmLwHkGXhvq+vVvr88amlicCbg9606 rogid:S8ihl3jxEEyMS46AM2ynXSFfCU49606 intact-crc:CDFAB9C4F7F44209|rigid:HJzSDg64i08arW1bmTNoyDj6WW0 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P62068 uniprotkb:Q8TBZ3 intact:EBI-2512753|ensembl:ENSP00000407818|uniprotkb:B7Z675|uniprotkb:Q9H7U4|uniprotkb:B7Z7S3|uniprotkb:B7Z3Y7|uniprotkb:Q80V95|uniprotkb:Q9H9T8|uniprotkb:G8ACC7 intact:EBI-2511486|ensembl:ENSP00000341037|uniprotkb:Q8WXX2|uniprotkb:Q9UF86|uniprotkb:Q8NCN7|intact:EBI-11109494|uniprotkb:H0YJJ1|uniprotkb:Q86TU2|uniprotkb:B4DN18|uniprotkb:E7EUY8|uniprotkb:F8W9S4|uniprotkb:G3V2F8|uniprotkb:G3V5R0 psi-mi:ubp46_human(display_long)|uniprotkb:USP46(gene name)|psi-mi:USP46(display_short)|uniprotkb:Ubiquitin-specific-processing protease 46(gene name synonym)|uniprotkb:Deubiquitinating enzyme 46(gene name synonym)|uniprotkb:Ubiquitin thioesterase 46(gene name synonym) psi-mi:wdr20_human(display_long)|uniprotkb:WDR20(gene name)|psi-mi:WDR20(display_short)|uniprotkb:Protein DMR(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512751|imex:IM-12079-25 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000109189(gene)|ensembl:ENST00000441222(transcript)|go:"GO:0001662"(behavioral fear response)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008343"(adult feeding behavior)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0032228"(regulation of synaptic transmission, GABAergic)|go:"GO:0046872"(metal ion binding)|go:"GO:0048149"(behavioral response to ethanol)|go:"GO:0060013"(righting reflex)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|mint:P62068|rcsb pdb:5CVM|rcsb pdb:5CVN|rcsb pdb:5CVO|rcsb pdb:5L8H|rcsb pdb:6JLQ|refseq:NP_001273696.1|refseq:NP_001273697.1|refseq:NP_001127695.1|refseq:NP_073743.2|dip:DIP-53590N ensembl:ENSG00000140153(gene)|ensembl:ENST00000342702(transcript)|go:"GO:0005654"(nucleoplasm)|interpro:IPR001680(WD40 repeat)|interpro:IPR036322|mint:Q8TBZ3|rcsb pdb:5K19|rcsb pdb:5K1C|rcsb pdb:6JLQ|reactome:R-HSA-5689880|refseq:NP_001229343.1|refseq:NP_001229345.1|refseq:NP_001229346.1|refseq:NP_001229347.1|refseq:NP_653175.2|refseq:NP_851808.1|refseq:NP_851825.1|refseq:NP_001229344.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/05/28 rogid:MYmLwHkGXhvq+vVvr88amlicCbg9606 rogid:2MfZps9YU8xQbWazkq2sIqXjHHg9606 intact-crc:CDFAB9C4F7F44209|rigid:HJzSDg64i08arW1bmTNoyDj6WW0 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P62068 uniprotkb:O75317 intact:EBI-2512753|ensembl:ENSP00000407818|uniprotkb:B7Z675|uniprotkb:Q9H7U4|uniprotkb:B7Z7S3|uniprotkb:B7Z3Y7|uniprotkb:Q80V95|uniprotkb:Q9H9T8|uniprotkb:G8ACC7 intact:EBI-2511507|ensembl:ENSP00000282344|uniprotkb:Q8TC49|uniprotkb:Q5VZV3|uniprotkb:A8K0X0 psi-mi:ubp46_human(display_long)|uniprotkb:USP46(gene name)|psi-mi:USP46(display_short)|uniprotkb:Ubiquitin-specific-processing protease 46(gene name synonym)|uniprotkb:Deubiquitinating enzyme 46(gene name synonym)|uniprotkb:Ubiquitin thioesterase 46(gene name synonym) psi-mi:ubp12_human(display_long)|uniprotkb:USP12(gene name)|psi-mi:USP12(display_short)|uniprotkb:UBH1(gene name synonym)|uniprotkb:USP12L1(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 12(gene name synonym)|uniprotkb:Deubiquitinating enzyme 12(gene name synonym)|uniprotkb:Ubiquitin-hydrolyzing enzyme 1(gene name synonym)|uniprotkb:Ubiquitin thioesterase 12(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512751|imex:IM-12079-25 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000109189(gene)|ensembl:ENST00000441222(transcript)|go:"GO:0001662"(behavioral fear response)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008343"(adult feeding behavior)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0032228"(regulation of synaptic transmission, GABAergic)|go:"GO:0046872"(metal ion binding)|go:"GO:0048149"(behavioral response to ethanol)|go:"GO:0060013"(righting reflex)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|mint:P62068|rcsb pdb:5CVM|rcsb pdb:5CVN|rcsb pdb:5CVO|rcsb pdb:5L8H|rcsb pdb:6JLQ|refseq:NP_001273696.1|refseq:NP_001273697.1|refseq:NP_001127695.1|refseq:NP_073743.2|dip:DIP-53590N ensembl:ENSG00000152484(gene)|ensembl:ENST00000282344(transcript)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0046872"(metal ion binding)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|mint:O75317|rcsb pdb:5K16|rcsb pdb:5K1A|rcsb pdb:5K1B|rcsb pdb:5K1C|rcsb pdb:5L8W|reactome:R-HSA-5689880|refseq:NP_872294.2 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/05/28 rogid:MYmLwHkGXhvq+vVvr88amlicCbg9606 rogid:SiueMBicjAsFl2OGlBfQ6tg1cf89606 intact-crc:CDFAB9C4F7F44209|rigid:HJzSDg64i08arW1bmTNoyDj6WW0 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P62068 uniprotkb:Q01105 intact:EBI-2512753|ensembl:ENSP00000407818|uniprotkb:B7Z675|uniprotkb:Q9H7U4|uniprotkb:B7Z7S3|uniprotkb:B7Z3Y7|uniprotkb:Q80V95|uniprotkb:Q9H9T8|uniprotkb:G8ACC7 intact:EBI-1053182|uniprotkb:A5A5H4|uniprotkb:Q15541|uniprotkb:Q5VXV1|uniprotkb:Q6FHZ5|intact:EBI-2559610|uniprotkb:A6NGV1|uniprotkb:B4DUE2|intact:EBI-4290953|uniprotkb:Q5VXV2|ensembl:ENSP00000361777 psi-mi:ubp46_human(display_long)|uniprotkb:USP46(gene name)|psi-mi:USP46(display_short)|uniprotkb:Ubiquitin-specific-processing protease 46(gene name synonym)|uniprotkb:Deubiquitinating enzyme 46(gene name synonym)|uniprotkb:Ubiquitin thioesterase 46(gene name synonym) psi-mi:set_human(display_long)|uniprotkb:Phosphatase 2A inhibitor I2PP2A(gene name synonym)|uniprotkb:Template-activating factor I(gene name synonym)|uniprotkb:HLA-DR-associated protein II(gene name synonym)|uniprotkb:PHAPII(gene name synonym)|uniprotkb:Inhibitor of granzyme A-activated DNase(gene name synonym)|uniprotkb:SET(gene name)|psi-mi:SET(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512751|imex:IM-12079-25 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000109189(gene)|ensembl:ENST00000441222(transcript)|go:"GO:0001662"(behavioral fear response)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008343"(adult feeding behavior)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0032228"(regulation of synaptic transmission, GABAergic)|go:"GO:0046872"(metal ion binding)|go:"GO:0048149"(behavioral response to ethanol)|go:"GO:0060013"(righting reflex)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|mint:P62068|rcsb pdb:5CVM|rcsb pdb:5CVN|rcsb pdb:5CVO|rcsb pdb:5L8H|rcsb pdb:6JLQ|refseq:NP_001273696.1|refseq:NP_001273697.1|refseq:NP_001127695.1|refseq:NP_073743.2|dip:DIP-53590N refseq:NP_001116293.1|refseq:NP_003002.2|dip:DIP-33561N|refseq:NP_001234930.1|refseq:NP_001234929.1|ensembl:ENSG00000119335(gene)|ensembl:ENST00000372692(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0004864"(protein phosphatase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006337"(nucleosome disassembly)|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042393"(histone binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|interpro:IPR002164("Nucleosome assembly protein (NAP)")|interpro:IPR037231|mint:Q01105|rcsb pdb:2E50|rcsb pdb:7MTO|reactome:R-HSA-2299718|reactome:R-HSA-450520|go:"GO:0035067"(negative regulation of histone acetylation) psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/05/28 rogid:MYmLwHkGXhvq+vVvr88amlicCbg9606 rogid:CBwf28rN/LSY/vhw7jxRHKP8q0k9606 intact-crc:CDFAB9C4F7F44209|rigid:HJzSDg64i08arW1bmTNoyDj6WW0 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P62068 uniprotkb:Q9BS26 intact:EBI-2512753|ensembl:ENSP00000407818|uniprotkb:B7Z675|uniprotkb:Q9H7U4|uniprotkb:B7Z7S3|uniprotkb:B7Z3Y7|uniprotkb:Q80V95|uniprotkb:Q9H9T8|uniprotkb:G8ACC7 intact:EBI-541644|uniprotkb:O60319|uniprotkb:Q5VWZ7|uniprotkb:Q6UW14|uniprotkb:Q8WX67|intact:EBI-1054855|uniprotkb:Q4VXC1|ensembl:ENSP00000262455 psi-mi:ubp46_human(display_long)|uniprotkb:USP46(gene name)|psi-mi:USP46(display_short)|uniprotkb:Ubiquitin-specific-processing protease 46(gene name synonym)|uniprotkb:Deubiquitinating enzyme 46(gene name synonym)|uniprotkb:Ubiquitin thioesterase 46(gene name synonym) psi-mi:erp44_human(display_long)|uniprotkb:ERP44(gene name)|psi-mi:ERP44(display_short)|uniprotkb:UNQ532/PRO1075(orf name)|uniprotkb:TXNDC4(gene name synonym)|uniprotkb:Thioredoxin domain-containing protein 4(gene name synonym)|uniprotkb:KIAA0573(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512751|imex:IM-12079-25 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000109189(gene)|ensembl:ENST00000441222(transcript)|go:"GO:0001662"(behavioral fear response)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008343"(adult feeding behavior)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0032228"(regulation of synaptic transmission, GABAergic)|go:"GO:0046872"(metal ion binding)|go:"GO:0048149"(behavioral response to ethanol)|go:"GO:0060013"(righting reflex)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|mint:P62068|rcsb pdb:5CVM|rcsb pdb:5CVN|rcsb pdb:5CVO|rcsb pdb:5L8H|rcsb pdb:6JLQ|refseq:NP_001273696.1|refseq:NP_001273697.1|refseq:NP_001127695.1|refseq:NP_073743.2|dip:DIP-53590N ensembl:ENSG00000023318(gene)|ensembl:ENST00000262455(transcript)|go:"GO:0003756"(protein disulfide isomerase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0006457"(protein folding)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0009986"(cell surface)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035580"(specific granule lumen)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0070062"(extracellular exosome)|interpro:IPR013766(Thioredoxin domain)|interpro:IPR036249|interpro:IPR041862|interpro:IPR041870|mint:Q9BS26|rcsb pdb:2R2J|rcsb pdb:5GU6|rcsb pdb:5GU7|rcsb pdb:5HQP|rcsb pdb:5XWM|reactome:R-HSA-6798695|go:"GO:0009100"(glycoprotein metabolic process)|refseq:NP_055866.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/05/28 rogid:MYmLwHkGXhvq+vVvr88amlicCbg9606 rogid:TpwaFRifveb03iRPS2pEZve1kLA9606 intact-crc:CDFAB9C4F7F44209|rigid:HJzSDg64i08arW1bmTNoyDj6WW0 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P62068 uniprotkb:Q09019 intact:EBI-2512753|ensembl:ENSP00000407818|uniprotkb:B7Z675|uniprotkb:Q9H7U4|uniprotkb:B7Z7S3|uniprotkb:B7Z3Y7|uniprotkb:Q80V95|uniprotkb:Q9H9T8|uniprotkb:G8ACC7 intact:EBI-724564|ensembl:ENSP00000270223 psi-mi:ubp46_human(display_long)|uniprotkb:USP46(gene name)|psi-mi:USP46(display_short)|uniprotkb:Ubiquitin-specific-processing protease 46(gene name synonym)|uniprotkb:Deubiquitinating enzyme 46(gene name synonym)|uniprotkb:Ubiquitin thioesterase 46(gene name synonym) psi-mi:dmwd_human(display_long)|uniprotkb:Dystrophia myotonica-containing WD repeat motif protein(gene name synonym)|uniprotkb:Protein DMR-N9(gene name synonym)|uniprotkb:Protein 59(gene name synonym)|uniprotkb:DMWD(gene name)|psi-mi:DMWD(display_short)|uniprotkb:DM9(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512751|imex:IM-12079-25 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000109189(gene)|ensembl:ENST00000441222(transcript)|go:"GO:0001662"(behavioral fear response)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008343"(adult feeding behavior)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0032228"(regulation of synaptic transmission, GABAergic)|go:"GO:0046872"(metal ion binding)|go:"GO:0048149"(behavioral response to ethanol)|go:"GO:0060013"(righting reflex)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|mint:P62068|rcsb pdb:5CVM|rcsb pdb:5CVN|rcsb pdb:5CVO|rcsb pdb:5L8H|rcsb pdb:6JLQ|refseq:NP_001273696.1|refseq:NP_001273697.1|refseq:NP_001127695.1|refseq:NP_073743.2|dip:DIP-53590N refseq:NP_004934.1|ensembl:ENSG00000185800(gene)|ensembl:ENST00000270223(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0030425"(dendrite)|go:"GO:0043204"(perikaryon)|interpro:IPR001680(WD40 repeat)|interpro:IPR036322|mint:Q09019 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/05/28 rogid:MYmLwHkGXhvq+vVvr88amlicCbg9606 rogid:76SLwlB1ohLxjwUwpPOR6gT4DP89606 intact-crc:CDFAB9C4F7F44209|rigid:HJzSDg64i08arW1bmTNoyDj6WW0 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P62068 uniprotkb:P46940 intact:EBI-2512753|ensembl:ENSP00000407818|uniprotkb:B7Z675|uniprotkb:Q9H7U4|uniprotkb:B7Z7S3|uniprotkb:B7Z3Y7|uniprotkb:Q80V95|uniprotkb:Q9H9T8|uniprotkb:G8ACC7 intact:EBI-297509|ensembl:ENSP00000268182|uniprotkb:A7MBM3 psi-mi:ubp46_human(display_long)|uniprotkb:USP46(gene name)|psi-mi:USP46(display_short)|uniprotkb:Ubiquitin-specific-processing protease 46(gene name synonym)|uniprotkb:Deubiquitinating enzyme 46(gene name synonym)|uniprotkb:Ubiquitin thioesterase 46(gene name synonym) psi-mi:iqga1_human(display_long)|uniprotkb:IQGAP1(gene name)|psi-mi:IQGAP1(display_short)|uniprotkb:KIAA0051(gene name synonym)|uniprotkb:p195(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512751|imex:IM-12079-25 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000109189(gene)|ensembl:ENST00000441222(transcript)|go:"GO:0001662"(behavioral fear response)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008343"(adult feeding behavior)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0032228"(regulation of synaptic transmission, GABAergic)|go:"GO:0046872"(metal ion binding)|go:"GO:0048149"(behavioral response to ethanol)|go:"GO:0060013"(righting reflex)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|mint:P62068|rcsb pdb:5CVM|rcsb pdb:5CVN|rcsb pdb:5CVO|rcsb pdb:5L8H|rcsb pdb:6JLQ|refseq:NP_001273696.1|refseq:NP_001273697.1|refseq:NP_001127695.1|refseq:NP_073743.2|dip:DIP-53590N ensembl:ENSG00000140575(gene)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|ensembl:ENST00000268182(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0005925"(focal adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005095"(GTPase inhibitor activity)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0016477"(cell migration)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0030496"(midbody)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036057"(slit diaphragm)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0043005"(neuron projection)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0044548"(S100 protein binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045296"(cadherin binding)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0051015"(actin filament binding)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0072015"(glomerular visceral epithelial cell development)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900086"(positive regulation of peptidyl-tyrosine autophosphorylation)|go:"GO:1903829"(positive regulation of protein localization)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|go:"GO:1990138"(neuron projection extension)|go:"GO:1990776"(response to angiotensin)|interpro:IPR000048(IQ calmodulin-binding region)|go:"GO:0030667"(secretory granule membrane)|interpro:IPR000593(RasGAP protein, C-terminal)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR023152|interpro:IPR027417|interpro:IPR036872|mint:P46940|rcsb pdb:1X0H|rcsb pdb:2RR8|rcsb pdb:3FAY|rcsb pdb:3I6X|rcsb pdb:5L0O|reactome:R-HSA-373753|reactome:R-HSA-381676|reactome:R-HSA-5626467|reactome:R-HSA-5674135|reactome:R-HSA-6798695|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-8980692|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013420|reactome:R-HSA-9013424|reactome:R-HSA-9649948|reactome:R-HSA-9656223|refseq:NP_003861.1|dip:DIP-32597N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/05/28 rogid:MYmLwHkGXhvq+vVvr88amlicCbg9606 rogid:nXO2Z6Qn8EQGfziT8dnWz1pbK/w9606 intact-crc:CDFAB9C4F7F44209|rigid:HJzSDg64i08arW1bmTNoyDj6WW0 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P62068 uniprotkb:Q04917 intact:EBI-2512753|ensembl:ENSP00000407818|uniprotkb:B7Z675|uniprotkb:Q9H7U4|uniprotkb:B7Z7S3|uniprotkb:B7Z3Y7|uniprotkb:Q80V95|uniprotkb:Q9H9T8|uniprotkb:G8ACC7 intact:EBI-306940|ensembl:ENSP00000248975|intact:EBI-11759595 psi-mi:ubp46_human(display_long)|uniprotkb:USP46(gene name)|psi-mi:USP46(display_short)|uniprotkb:Ubiquitin-specific-processing protease 46(gene name synonym)|uniprotkb:Deubiquitinating enzyme 46(gene name synonym)|uniprotkb:Ubiquitin thioesterase 46(gene name synonym) psi-mi:1433f_human(display_long)|uniprotkb:YWHAH(gene name)|psi-mi:YWHAH(display_short)|uniprotkb:YWHA1(gene name synonym)|uniprotkb:Protein AS1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512751|imex:IM-12079-25 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000109189(gene)|ensembl:ENST00000441222(transcript)|go:"GO:0001662"(behavioral fear response)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008343"(adult feeding behavior)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0032228"(regulation of synaptic transmission, GABAergic)|go:"GO:0046872"(metal ion binding)|go:"GO:0048149"(behavioral response to ethanol)|go:"GO:0060013"(righting reflex)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|mint:P62068|rcsb pdb:5CVM|rcsb pdb:5CVN|rcsb pdb:5CVO|rcsb pdb:5L8H|rcsb pdb:6JLQ|refseq:NP_001273696.1|refseq:NP_001273697.1|refseq:NP_001127695.1|refseq:NP_073743.2|dip:DIP-53590N go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0050774"(negative regulation of dendrite morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0086010"(membrane depolarization during action potential)|go:"GO:2000649"(regulation of sodium ion transmembrane transporter activity)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:Q04917|rcsb pdb:2C63|rcsb pdb:2C74|reactome:R-HSA-111447|reactome:R-HSA-1445148|reactome:R-HSA-5625740|reactome:R-HSA-5628897|reactome:R-HSA-75035|ensembl:ENSG00000128245(gene)|ensembl:ENST00000248975(transcript)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0003779"(actin binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006713"(glucocorticoid catabolic process)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0014704"(intercalated disc)|go:"GO:0017080"(sodium channel regulator activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021762"(substantia nigra development)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042921"(glucocorticoid receptor signaling pathway)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|refseq:NP_003396.1|dip:DIP-27566N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/05/28 rogid:MYmLwHkGXhvq+vVvr88amlicCbg9606 rogid:VhFYPSsW3IRC388FTlmwwN37HnU9606 intact-crc:CDFAB9C4F7F44209|rigid:HJzSDg64i08arW1bmTNoyDj6WW0 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P62068 uniprotkb:O43164 intact:EBI-2512753|ensembl:ENSP00000407818|uniprotkb:B7Z675|uniprotkb:Q9H7U4|uniprotkb:B7Z7S3|uniprotkb:B7Z3Y7|uniprotkb:Q80V95|uniprotkb:Q9H9T8|uniprotkb:G8ACC7 intact:EBI-1996038|uniprotkb:D3DSZ5|uniprotkb:Q68D49|uniprotkb:Q8N1G5|uniprotkb:A8K6U4|ensembl:ENSP00000354775|ensembl:ENSP00000355284 psi-mi:ubp46_human(display_long)|uniprotkb:USP46(gene name)|psi-mi:USP46(display_short)|uniprotkb:Ubiquitin-specific-processing protease 46(gene name synonym)|uniprotkb:Deubiquitinating enzyme 46(gene name synonym)|uniprotkb:Ubiquitin thioesterase 46(gene name synonym) psi-mi:pja2_human(display_long)|uniprotkb:PJA2(gene name)|psi-mi:PJA2(display_short)|uniprotkb:KIAA0438(gene name synonym)|uniprotkb:RNF131(gene name synonym)|uniprotkb:RING finger protein 131(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase Praja-2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512751|imex:IM-12079-25 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000109189(gene)|ensembl:ENST00000441222(transcript)|go:"GO:0001662"(behavioral fear response)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008343"(adult feeding behavior)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0032228"(regulation of synaptic transmission, GABAergic)|go:"GO:0046872"(metal ion binding)|go:"GO:0048149"(behavioral response to ethanol)|go:"GO:0060013"(righting reflex)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|mint:P62068|rcsb pdb:5CVM|rcsb pdb:5CVN|rcsb pdb:5CVO|rcsb pdb:5L8H|rcsb pdb:6JLQ|refseq:NP_001273696.1|refseq:NP_001273697.1|refseq:NP_001127695.1|refseq:NP_073743.2|dip:DIP-53590N refseq:NP_055634.3|refseq:XP_016865588.1|ensembl:ENSG00000198961(gene)|ensembl:ENST00000361189(transcript)|ensembl:ENST00000361557(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007616"(long-term memory)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0034137"(positive regulation of toll-like receptor 2 signaling pathway)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0035329"(hippo signaling)|go:"GO:0043030"(regulation of macrophage activation)|go:"GO:0045087"(innate immune response)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046872"(metal ion binding)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR030639|mint:O43164|reactome:R-HSA-983168|dip:DIP-47040N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/05/28 rogid:MYmLwHkGXhvq+vVvr88amlicCbg9606 rogid:z0OkXLozXymqwyF+xQR+PFa+bQI9606 intact-crc:CDFAB9C4F7F44209|rigid:HJzSDg64i08arW1bmTNoyDj6WW0 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q86UV5 intact:EBI-2509390 intact:EBI-2512161|uniprotkb:Q2M3I4|uniprotkb:Q5SZI4|uniprotkb:Q96IQ3|uniprotkb:Q8N3F6|uniprotkb:Q9NUJ6|uniprotkb:Q9H5N3|uniprotkb:Q9H5T7|uniprotkb:Q96F64|uniprotkb:Q9NXR0|uniprotkb:Q6NX53|uniprotkb:Q5T3T5|intact:EBI-2512805|uniprotkb:B7ZKS7|ensembl:ENSP00000309262 uniparc:UPI00004192AB psi-mi:ubp48_human(display_long)|uniprotkb:Ubiquitin-specific peptidase 48(gene name synonym)|uniprotkb:Ubiquitin-specific protease 48(gene name synonym)|uniprotkb:USP48(gene name)|psi-mi:USP48(display_short)|uniprotkb:USP31(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 48(gene name synonym)|uniprotkb:Deubiquitinating enzyme 48(gene name synonym)|uniprotkb:Ubiquitin thioesterase 48(gene name synonym) psi-mi:ipi00455773(display_short)|psi-mi:EBI-2509390(display_long) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512803|imex:IM-12079-76 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001027902.1|refseq:NP_115612.4|refseq:NP_001317323.1|ensembl:ENSG00000090686(gene)|ensembl:ENST00000308271(transcript)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|interpro:IPR000626(Ubiquitin)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR018200|interpro:IPR028889|interpro:IPR029071|interpro:IPR033841|interpro:IPR035927|interpro:IPR038765|interpro:IPR044743|reactome:R-HSA-5689880 - psi-mi:"MI:0469"(intact) - no-uniprot-update:An amino acid sequence which is not represented in UniProt figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:isCDJibvxhTQ6G+bIdJ2/vsNSRY9606 rogid:LNN6U3DSQb3WiVsMGHuYSDe0PKM9606 intact-crc:34A01F99B525C7C1|rigid:xaGaTL7vYqwMEyfOiq9fNVIsEoE false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q70CQ1 uniprotkb:Q7Z6Z7 intact:EBI-2511022|ensembl:ENSP00000377797|ensembl:ENSP00000507239|uniprotkb:Q5T3E0|uniprotkb:Q5T3D9|uniprotkb:Q96CK4 intact:EBI-625934|uniprotkb:O15029|uniprotkb:Q4G2Z2|uniprotkb:Q5H961|uniprotkb:Q6P4D0|uniprotkb:Q8NG67|uniprotkb:Q9BUI0|uniprotkb:Q9HCJ4|uniprotkb:Q9NSL6|uniprotkb:Q9P0A9|ensembl:ENSP00000262854|ensembl:ENSP00000340648 psi-mi:ubp49_human(display_long)|uniprotkb:USP49(gene name)|psi-mi:USP49(display_short)|uniprotkb:Ubiquitin thioesterase 49(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 49(gene name synonym)|uniprotkb:Deubiquitinating enzyme 49(gene name synonym) psi-mi:huwe1_human(display_long)|uniprotkb:HECT, UBA and WWE domain-containing protein 1(gene name synonym)|uniprotkb:Upstream regulatory element-binding protein 1(gene name synonym)|uniprotkb:Mcl-1 ubiquitin ligase E3(gene name synonym)|uniprotkb:ARF-binding protein 1(gene name synonym)|uniprotkb:Large structure of UREB1(gene name synonym)|uniprotkb:Homologous to E6AP carboxyl terminus homologous protein 9(gene name synonym)|uniprotkb:HUWE1(gene name)|psi-mi:HUWE1(display_short)|uniprotkb:KIAA0312(gene name synonym)|uniprotkb:KIAA1578(gene name synonym)|uniprotkb:HSPC272(orf name)|uniprotkb:HECT-type E3 ubiquitin transferase HUWE1(gene name synonym)|uniprotkb:UREB1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512828|imex:IM-12079-26 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001273483.1|ensembl:ENSG00000164663(gene)|ensembl:ENST00000394253(transcript)|ensembl:ENST00000682992(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035616"(histone H2B conserved C-terminal lysine deubiquitination)|go:"GO:0042393"(histone binding)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|interpro:IPR028889|reactome:R-HSA-5689880|interpro:IPR038765|refseq:NP_061031.2 ensembl:ENSG00000086758(gene)|ensembl:ENST00000262854(transcript)|ensembl:ENST00000342160(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006284"(base-excision repair)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0007030"(Golgi organization)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0030154"(cell differentiation)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000569(HECT)|interpro:IPR004170(WWE)|interpro:IPR009060(UBA-like)|interpro:IPR010309(E3 ubiquitin ligase, region of unknown function DUF908)|interpro:IPR010314(E3 ubiquitin ligase, region of unknown function DUF913)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR025527|interpro:IPR035983|interpro:IPR037197|interpro:IPR041918|mint:Q7Z6Z7|rcsb pdb:2EKK|rcsb pdb:2MUL|rcsb pdb:3G1N|go:"GO:0061025"(membrane fusion)|rcsb pdb:5C6H|rcsb pdb:5LP8|rcsb pdb:6FYH|rcsb pdb:6MIW|rcsb pdb:6PFL|reactome:R-HSA-6798695|rcsb pdb:3H1D|reactome:R-HSA-983168|refseq:NP_113584.3|refseq:XP_005262022.1|dip:DIP-34362N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:/u6RWNsUrEKz5MecLGyv4+elO309606 rogid:TnIn0mcFc81bJlMkyWTtq3n/uOg9606 intact-crc:D82E0F9129BB1387|rigid:YpJJ8dfozFePCNm4CCpATa4O/Is false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q70CQ1 uniprotkb:P17612 intact:EBI-2511022|ensembl:ENSP00000377797|ensembl:ENSP00000507239|uniprotkb:Q5T3E0|uniprotkb:Q5T3D9|uniprotkb:Q96CK4 intact:EBI-476586|uniprotkb:Q32P54|uniprotkb:Q9H2Y0|uniprotkb:Q9NRB4|uniprotkb:Q9NRH9|ensembl:ENSP00000309591|ensembl:ENSP00000499940 psi-mi:ubp49_human(display_long)|uniprotkb:USP49(gene name)|psi-mi:USP49(display_short)|uniprotkb:Ubiquitin thioesterase 49(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 49(gene name synonym)|uniprotkb:Deubiquitinating enzyme 49(gene name synonym) psi-mi:kapca_human(display_long)|uniprotkb:PRKACA(gene name)|psi-mi:PRKACA(display_short)|uniprotkb:PKACA(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512828|imex:IM-12079-26 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001273483.1|ensembl:ENSG00000164663(gene)|ensembl:ENST00000394253(transcript)|ensembl:ENST00000682992(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035616"(histone H2B conserved C-terminal lysine deubiquitination)|go:"GO:0042393"(histone binding)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|interpro:IPR028889|reactome:R-HSA-5689880|interpro:IPR038765|refseq:NP_061031.2 refseq:NP_002721.1|refseq:NP_997401.1|go:"GO:0005739"(mitochondrion)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005952"(cAMP-dependent protein kinase complex)|go:"GO:0006397"(mRNA processing)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0010737"(protein kinase A signaling)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0016020"(membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016607"(nuclear speck)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|ensembl:ENSG00000072062(gene)|ensembl:ENSG00000288516(gene)|ensembl:ENST00000308677(transcript)|ensembl:ENST00000673550(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001843"(neural tube closure)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0003091"(renal water homeostasis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004679"(AMP-activated protein kinase activity)|go:"GO:0004691"(cAMP-dependent protein kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0034380"(high-density lipoprotein particle assembly)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034704"(calcium channel complex)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0036126"(sperm flagellum)|go:"GO:0043197"(dendritic spine)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0048240"(sperm capacitation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0060314"(regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070613"(regulation of protein processing)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0071872"(cellular response to epinephrine stimulus)|go:"GO:0086064"(cell communication by electrical coupling involved in cardiac conduction)|go:"GO:0097225"(sperm midpiece)|go:"GO:0097546"(ciliary base)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901621"(negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning)|go:"GO:1903779"(regulation of cardiac conduction)|go:"GO:2000810"(regulation of bicellular tight junction assembly)|go:"GO:0046827"(positive regulation of protein export from nucleus)|rcsb pdb:5IZJ|rcsb pdb:5J5X|rcsb pdb:5N23|rcsb pdb:5UZK|rcsb pdb:6BYR|rcsb pdb:6BYS|rcsb pdb:6C0U|rcsb pdb:6FRX|rcsb pdb:6NO7|rcsb pdb:6QJ7|rcsb pdb:6WJF|rcsb pdb:6WJG|reactome:R-HSA-111931|reactome:R-HSA-163358|reactome:R-HSA-163560|reactome:R-HSA-163615|reactome:R-HSA-164378|reactome:R-HSA-180024|reactome:R-HSA-2565942|reactome:R-HSA-380259|rcsb pdb:3MVJ|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:3NX8|interpro:IPR044109|rcsb pdb:3OOG|rcsb pdb:3OVV|rcsb pdb:3OWP|rcsb pdb:3OXT|rcsb pdb:3P0M|mint:P17612|rcsb pdb:3POO|rcsb pdb:3VQH|rcsb pdb:4AE6|rcsb pdb:2GU8|rcsb pdb:4AE9|rcsb pdb:4UJ1|rcsb pdb:4UJ2|rcsb pdb:3AGL|rcsb pdb:3AGM|rcsb pdb:3AMA|rcsb pdb:3AMB|rcsb pdb:4UJ9|rcsb pdb:4UJA|rcsb pdb:4UJB|rcsb pdb:4WB5|rcsb pdb:4WB6|rcsb pdb:4WB7|rcsb pdb:3L9L|rcsb pdb:3L9M|rcsb pdb:3L9N|rcsb pdb:4WB8|rcsb pdb:5BX6|rcsb pdb:5BX7|rcsb pdb:5IZF|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-381676|reactome:R-HSA-392517|reactome:R-HSA-422356|reactome:R-HSA-432040|reactome:R-HSA-4420097|reactome:R-HSA-442720|reactome:R-HSA-512988|reactome:R-HSA-5578775|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5610787|reactome:R-HSA-5620912|reactome:R-HSA-5621575|reactome:R-HSA-5687128|reactome:R-HSA-8853659|reactome:R-HSA-8854518|reactome:R-HSA-380320|reactome:R-HSA-8963896|reactome:R-HSA-9022535|reactome:R-HSA-9022692|reactome:R-HSA-9634600|reactome:R-HSA-9660821|reactome:R-HSA-9664323|reactome:R-HSA-983231|reactome:R-HSA-9010642|refseq:NP_001291278.1|dip:DIP-33878N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:/u6RWNsUrEKz5MecLGyv4+elO309606 rogid:7yhAi67qjSKPIff2dwqjScPXEYM9606 intact-crc:D82E0F9129BB1387|rigid:YpJJ8dfozFePCNm4CCpATa4O/Is false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q70CQ1 uniprotkb:Q8NB46 intact:EBI-2511022|ensembl:ENSP00000377797|ensembl:ENSP00000507239|uniprotkb:Q5T3E0|uniprotkb:Q5T3D9|uniprotkb:Q96CK4 intact:EBI-1996119|uniprotkb:B1Q2K2|uniprotkb:A6NE79|ensembl:ENSP00000267116 psi-mi:ubp49_human(display_long)|uniprotkb:USP49(gene name)|psi-mi:USP49(display_short)|uniprotkb:Ubiquitin thioesterase 49(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 49(gene name synonym)|uniprotkb:Deubiquitinating enzyme 49(gene name synonym) psi-mi:anr52_human(display_long)|uniprotkb:ANKRD52(gene name)|psi-mi:ANKRD52(display_short)|uniprotkb:Ankyrin repeat domain-containing protein 52(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512828|imex:IM-12079-26 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001273483.1|ensembl:ENSG00000164663(gene)|ensembl:ENST00000394253(transcript)|ensembl:ENST00000682992(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035616"(histone H2B conserved C-terminal lysine deubiquitination)|go:"GO:0042393"(histone binding)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|interpro:IPR028889|reactome:R-HSA-5689880|interpro:IPR038765|refseq:NP_061031.2 refseq:NP_775866.2|ensembl:ENSG00000139645(gene)|ensembl:ENST00000267116(transcript)|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR036770 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:/u6RWNsUrEKz5MecLGyv4+elO309606 rogid:yDxfgyMLVZlGwQW0OSokGlMkmPo9606 intact-crc:D82E0F9129BB1387|rigid:YpJJ8dfozFePCNm4CCpATa4O/Is false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q70CQ1 uniprotkb:Q96P70 intact:EBI-2511022|ensembl:ENSP00000377797|ensembl:ENSP00000507239|uniprotkb:Q5T3E0|uniprotkb:Q5T3D9|uniprotkb:Q96CK4 intact:EBI-356319|intact:EBI-1059309|uniprotkb:Q8N1Y1|uniprotkb:Q8N3I2|uniprotkb:Q8NCG9|uniprotkb:Q96SU6|uniprotkb:Q9NW01|uniprotkb:Q9P0A8|uniprotkb:Q9ULM8|ensembl:ENSP00000354742|uniprotkb:B1ASV5 psi-mi:ubp49_human(display_long)|uniprotkb:USP49(gene name)|psi-mi:USP49(display_short)|uniprotkb:Ubiquitin thioesterase 49(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 49(gene name synonym)|uniprotkb:Deubiquitinating enzyme 49(gene name synonym) psi-mi:ipo9_human(display_long)|uniprotkb:HSPC273(orf name)|uniprotkb:IPO9(gene name)|psi-mi:IPO9(display_short)|uniprotkb:IMP9(gene name synonym)|uniprotkb:KIAA1192(gene name synonym)|uniprotkb:RANBP9(gene name synonym)|uniprotkb:Ran-binding protein 9(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512828|imex:IM-12079-26 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001273483.1|ensembl:ENSG00000164663(gene)|ensembl:ENST00000394253(transcript)|ensembl:ENST00000682992(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035616"(histone H2B conserved C-terminal lysine deubiquitination)|go:"GO:0042393"(histone binding)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|interpro:IPR028889|reactome:R-HSA-5689880|interpro:IPR038765|refseq:NP_061031.2 refseq:NP_060555.2|ensembl:ENSG00000198700(gene)|ensembl:ENST00000361565(transcript)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0016020"(membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0042393"(histone binding)|go:"GO:0061608"(nuclear import signal receptor activity)|interpro:IPR001494(Importin-beta, N-terminal)|interpro:IPR016024(Armadillo-type fold)|mint:Q96P70|rcsb pdb:6N1Z psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:/u6RWNsUrEKz5MecLGyv4+elO309606 rogid:jsjQSBULeF1L2FlDcPZouMz6pJE9606 intact-crc:D82E0F9129BB1387|rigid:YpJJ8dfozFePCNm4CCpATa4O/Is false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q70CQ1 uniprotkb:P40939 intact:EBI-2511022|ensembl:ENSP00000377797|ensembl:ENSP00000507239|uniprotkb:Q5T3E0|uniprotkb:Q5T3D9|uniprotkb:Q96CK4 intact:EBI-356720|uniprotkb:Q16679|uniprotkb:Q96GT7|uniprotkb:B2R7L4|uniprotkb:B4DYP2|uniprotkb:Q9UQC5|ensembl:ENSP00000370023|uniprotkb:Q53T69|uniprotkb:Q53TA2 psi-mi:ubp49_human(display_long)|uniprotkb:USP49(gene name)|psi-mi:USP49(display_short)|uniprotkb:Ubiquitin thioesterase 49(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 49(gene name synonym)|uniprotkb:Deubiquitinating enzyme 49(gene name synonym) psi-mi:echa_human(display_long)|uniprotkb:HADHA(gene name)|psi-mi:HADHA(display_short)|uniprotkb:HADH(gene name synonym)|uniprotkb:TP-alpha(gene name synonym)|uniprotkb:78 kDa gastrin-binding protein(gene name synonym)|uniprotkb:Monolysocardiolipin acyltransferase(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512828|imex:IM-12079-26 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001273483.1|ensembl:ENSG00000164663(gene)|ensembl:ENST00000394253(transcript)|ensembl:ENST00000682992(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035616"(histone H2B conserved C-terminal lysine deubiquitination)|go:"GO:0042393"(histone binding)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|interpro:IPR028889|reactome:R-HSA-5689880|interpro:IPR038765|refseq:NP_061031.2 refseq:NP_000173.2|ensembl:ENSG00000084754(gene)|ensembl:ENST00000380649(transcript)|go:"GO:0000062"(fatty-acyl-CoA binding)|go:"GO:0003857"(3-hydroxyacyl-CoA dehydrogenase activity)|go:"GO:0003985"(acetyl-CoA C-acetyltransferase activity)|go:"GO:0004300"(enoyl-CoA hydratase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0016507"(mitochondrial fatty acid beta-oxidation multienzyme complex)|go:"GO:0016508"(long-chain-enoyl-CoA hydratase activity)|go:"GO:0016509"(long-chain-3-hydroxyacyl-CoA dehydrogenase activity)|go:"GO:0032868"(response to insulin)|go:"GO:0035965"(cardiolipin acyl-chain remodeling)|go:"GO:0042493"|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0070403"(NAD+ binding)|interpro:IPR001753(Crotonase, core)|interpro:IPR006108(3-hydroxyacyl-CoA dehydrogenase, C-terminal)|interpro:IPR006176(3-hydroxyacyl-CoA dehydrogenase, NAD binding)|interpro:IPR006180(3-hydroxyacyl-CoA dehydrogenase, conserved site)|interpro:IPR008927(6-phosphogluconate dehydrogenase, C-terminal-like)|interpro:IPR012803(Fatty acid oxidation complex, alpha subunit, mitochondrial)|interpro:IPR018376|interpro:IPR029045|interpro:IPR036291|mint:P40939|rcsb pdb:5ZQZ|rcsb pdb:5ZRV|rcsb pdb:6DV2|reactome:R-HSA-1482798|reactome:R-HSA-77285|reactome:R-HSA-77288|reactome:R-HSA-77305|reactome:R-HSA-77310|reactome:R-HSA-77346|reactome:R-HSA-77348|reactome:R-HSA-77350 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:/u6RWNsUrEKz5MecLGyv4+elO309606 rogid:Dr5HQoO5+a+6Q9OtvDIhM4yw4Cg9606 intact-crc:D82E0F9129BB1387|rigid:YpJJ8dfozFePCNm4CCpATa4O/Is false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q70CQ1 uniprotkb:Q12798 intact:EBI-2511022|ensembl:ENSP00000377797|ensembl:ENSP00000507239|uniprotkb:Q5T3E0|uniprotkb:Q5T3D9|uniprotkb:Q96CK4 intact:EBI-2512818|ensembl:ENSP00000319052|uniprotkb:B2R536 psi-mi:ubp49_human(display_long)|uniprotkb:USP49(gene name)|psi-mi:USP49(display_short)|uniprotkb:Ubiquitin thioesterase 49(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 49(gene name synonym)|uniprotkb:Deubiquitinating enzyme 49(gene name synonym) psi-mi:cetn1_human(display_long)|uniprotkb:CETN1(gene name)|psi-mi:CETN1(display_short)|uniprotkb:CEN1(gene name synonym)|uniprotkb:CETN(gene name synonym)|uniprotkb:Caltractin isoform 2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512828|imex:IM-12079-26 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001273483.1|ensembl:ENSG00000164663(gene)|ensembl:ENST00000394253(transcript)|ensembl:ENST00000682992(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035616"(histone H2B conserved C-terminal lysine deubiquitination)|go:"GO:0042393"(histone binding)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|interpro:IPR028889|reactome:R-HSA-5689880|interpro:IPR038765|refseq:NP_061031.2 ensembl:ENSG00000177143(gene)|ensembl:ENST00000327228(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000922"(spindle pole)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0007099"(centriole replication)|go:"GO:0032391"(photoreceptor connecting cilium)|go:"GO:0051301"(cell division)|interpro:IPR000629(RNA helicase, ATP-dependent, DEAD-box, conserved site)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR029527|reactome:R-HSA-9613829|reactome:R-HSA-9615710|reactome:R-HSA-9646399|refseq:NP_004057.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:/u6RWNsUrEKz5MecLGyv4+elO309606 rogid:uZs9mMo7OXGTDDaadTQGyV/v0iM9606 intact-crc:D82E0F9129BB1387|rigid:YpJJ8dfozFePCNm4CCpATa4O/Is false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q70CQ1 uniprotkb:Q9UPY3 intact:EBI-2511022|ensembl:ENSP00000377797|ensembl:ENSP00000507239|uniprotkb:Q5T3E0|uniprotkb:Q5T3D9|uniprotkb:Q96CK4 intact:EBI-395506|uniprotkb:O95943|uniprotkb:Q9UQ02|uniprotkb:A7E2D3|ensembl:ENSP00000343745|ensembl:ENSP00000376783|ensembl:ENSP00000435681|ensembl:ENSP00000437256|uniprotkb:E0AD28|uniprotkb:B3KRG4 psi-mi:ubp49_human(display_long)|uniprotkb:USP49(gene name)|psi-mi:USP49(display_short)|uniprotkb:Ubiquitin thioesterase 49(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 49(gene name synonym)|uniprotkb:Deubiquitinating enzyme 49(gene name synonym) psi-mi:dicer_human(display_long)|uniprotkb:DICER1(gene name)|psi-mi:DICER1(display_short)|uniprotkb:DICER(gene name synonym)|uniprotkb:HERNA(gene name synonym)|uniprotkb:KIAA0928(gene name synonym)|uniprotkb:Helicase with RNase motif(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512828|imex:IM-12079-26 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001273483.1|ensembl:ENSG00000164663(gene)|ensembl:ENST00000394253(transcript)|ensembl:ENST00000682992(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035616"(histone H2B conserved C-terminal lysine deubiquitination)|go:"GO:0042393"(histone binding)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|interpro:IPR028889|reactome:R-HSA-5689880|interpro:IPR038765|refseq:NP_061031.2 refseq:NP_085124.2|refseq:NP_803187.1|refseq:NP_001182502.1|refseq:XP_011534901.1|refseq:XP_011534902.1|refseq:XP_011534903.1|refseq:XP_011534904.1|ensembl:ENSG00000100697(gene)|ensembl:ENST00000343455(transcript)|ensembl:ENST00000393063(transcript)|ensembl:ENST00000526495(transcript)|ensembl:ENST00000527414(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0004386"(helicase activity)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0004525"(ribonuclease III activity)|go:"GO:0004530"(deoxyribonuclease I activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005829"(cytosol)|go:"GO:0006309"(apoptotic DNA fragmentation)|go:"GO:0010586"(miRNA metabolic process)|go:"GO:0010626"(negative regulation of Schwann cell proliferation)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014040"(positive regulation of Schwann cell differentiation)|go:"GO:0016078"(tRNA catabolic process)|go:"GO:0016442"(RISC complex)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021675"(nerve development)|go:"GO:0030422"(production of siRNA involved in RNA interference)|go:"GO:0030423"(targeting of mRNA for destruction involved in RNA interference)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031054"(pre-miRNA processing)|go:"GO:0031643"(positive regulation of myelination)|go:"GO:0032290"(peripheral nervous system myelin formation)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0033167"(ARC complex)|go:"GO:0033168"(obsolete conversion of ds siRNA to ss siRNA involved in RNA interference)|go:"GO:0035087"(siRNA loading onto RISC involved in RNA interference)|go:"GO:0035196"(production of miRNAs involved in gene silencing by miRNA)|go:"GO:0035197"(siRNA binding)|go:"GO:0036404"(obsolete conversion of ds siRNA to ss siRNA)|go:"GO:0038061"(NIK/NF-kappaB signaling)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070578"(RISC-loading complex)|go:"GO:0070883"(pre-miRNA binding)|go:"GO:0090501"(RNA phosphodiester bond hydrolysis)|go:"GO:0090502"(RNA phosphodiester bond hydrolysis, endonucleolytic)|interpro:IPR000999(Ribonuclease III)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR003100(Argonaute and Dicer protein, PAZ)|interpro:IPR005034(Protein of unknown function DUF283)|interpro:IPR006935(Restriction endonuclease, type I, R subunit/Type III, Res subunit)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014720(Double-stranded RNA-binding-like)|interpro:IPR027417|interpro:IPR036085|interpro:IPR036389|interpro:IPR038248|interpro:IPR044441|mint:Q9UPY3|rcsb pdb:2EB1|rcsb pdb:4NGB|rcsb pdb:4NGC|rcsb pdb:4NGD|rcsb pdb:4NGF|rcsb pdb:4NGG|rcsb pdb:4NH3|rcsb pdb:4NH5|rcsb pdb:4NH6|rcsb pdb:4NHA|rcsb pdb:4WYQ|rcsb pdb:5ZAK|rcsb pdb:5ZAL|rcsb pdb:5ZAM|reactome:R-HSA-203927|reactome:R-HSA-426486|go:"GO:0035280"(miRNA loading onto RISC)|reactome:R-HSA-9708296|refseq:NP_001258211.1|refseq:NP_001278557.1|refseq:XP_016876609.1|refseq:XP_016876610.1|dip:DIP-29664N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:/u6RWNsUrEKz5MecLGyv4+elO309606 rogid:RhSXQEEvS9b0IOvnrPYhRd0MzI09606 intact-crc:D82E0F9129BB1387|rigid:YpJJ8dfozFePCNm4CCpATa4O/Is false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q70CQ1 uniprotkb:P53041 intact:EBI-2511022|ensembl:ENSP00000377797|ensembl:ENSP00000507239|uniprotkb:Q5T3E0|uniprotkb:Q5T3D9|uniprotkb:Q96CK4 intact:EBI-716663|uniprotkb:Q53XV2|uniprotkb:Q16722|ensembl:ENSP00000012443 psi-mi:ubp49_human(display_long)|uniprotkb:USP49(gene name)|psi-mi:USP49(display_short)|uniprotkb:Ubiquitin thioesterase 49(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 49(gene name synonym)|uniprotkb:Deubiquitinating enzyme 49(gene name synonym) psi-mi:ppp5_human(display_long)|uniprotkb:Protein phosphatase T(gene name synonym)|uniprotkb:PPP5C(gene name)|psi-mi:PPP5C(display_short)|uniprotkb:PPP5(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512828|imex:IM-12079-26 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001273483.1|ensembl:ENSG00000164663(gene)|ensembl:ENST00000394253(transcript)|ensembl:ENST00000682992(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035616"(histone H2B conserved C-terminal lysine deubiquitination)|go:"GO:0042393"(histone binding)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|interpro:IPR028889|reactome:R-HSA-5689880|interpro:IPR038765|refseq:NP_061031.2 refseq:NP_006238.1|ensembl:ENSG00000011485(gene)|ensembl:ENST00000012443(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001965"(G-protein alpha-subunit binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0008017"(microtubule binding)|go:"GO:0008289"(lipid binding)|go:"GO:0010288"(response to lead ion)|go:"GO:0016576"(histone dephosphorylation)|go:"GO:0016791"(phosphatase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035970"(peptidyl-threonine dephosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043204"(perikaryon)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043278"(response to morphine)|go:"GO:0043531"(ADP binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0101031"(chaperone complex)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1904550"(response to arachidonic acid)|go:"GO:1990635"(proximal dendrite)|go:"GO:2000324"(positive regulation of glucocorticoid receptor signaling pathway)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR011236(Protein phosphatase 5)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013235(Serine/threonine phosphatase, PPP5)|interpro:IPR019734|interpro:IPR029052|interpro:IPR041753|mint:P53041|rcsb pdb:1A17|rcsb pdb:1S95|rcsb pdb:1WAO|rcsb pdb:2BUG|rcsb pdb:3H60|rcsb pdb:3H61|rcsb pdb:3H62|rcsb pdb:3H63|rcsb pdb:3H64|rcsb pdb:3H66|rcsb pdb:3H67|rcsb pdb:3H68|rcsb pdb:3H69|rcsb pdb:4ZVZ|rcsb pdb:4ZX2|rcsb pdb:5HPE|rcsb pdb:5UI1|rcsb pdb:5WG8|reactome:R-HSA-5675221|reactome:R-HSA-5693565|reactome:R-HSA-8939211|dip:DIP-29043N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:/u6RWNsUrEKz5MecLGyv4+elO309606 rogid:5QoNB467ftOvWaUNfSm6RalR8+Y9606 intact-crc:D82E0F9129BB1387|rigid:YpJJ8dfozFePCNm4CCpATa4O/Is false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q70CQ1 uniprotkb:Q16342 intact:EBI-2511022|ensembl:ENSP00000377797|ensembl:ENSP00000507239|uniprotkb:Q5T3E0|uniprotkb:Q5T3D9|uniprotkb:Q96CK4 intact:EBI-359462|uniprotkb:Q9UH12|uniprotkb:E9PCU7|uniprotkb:F5GYS7|ensembl:ENSP00000439467|uniprotkb:Q58HM9|uniprotkb:Q58HN0 psi-mi:ubp49_human(display_long)|uniprotkb:USP49(gene name)|psi-mi:USP49(display_short)|uniprotkb:Ubiquitin thioesterase 49(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 49(gene name synonym)|uniprotkb:Deubiquitinating enzyme 49(gene name synonym) psi-mi:pdcd2_human(display_long)|uniprotkb:PDCD2(gene name)|psi-mi:PDCD2(display_short)|uniprotkb:RP8(gene name synonym)|uniprotkb:ZMYND7(gene name synonym)|uniprotkb:Zinc finger protein Rp-8(gene name synonym)|uniprotkb:Zinc finger MYND domain-containing protein 7(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512828|imex:IM-12079-26 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001273483.1|ensembl:ENSG00000164663(gene)|ensembl:ENST00000394253(transcript)|ensembl:ENST00000682992(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035616"(histone H2B conserved C-terminal lysine deubiquitination)|go:"GO:0042393"(histone binding)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|interpro:IPR028889|reactome:R-HSA-5689880|interpro:IPR038765|refseq:NP_061031.2 refseq:NP_002589.2|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1901532"(regulation of hematopoietic progenitor cell differentiation)|go:"GO:1902035"(positive regulation of hematopoietic stem cell proliferation)|interpro:IPR002893(Zinc finger, MYND-type)|interpro:IPR007320(Programmed cell death protein 2, C-terminal)|mint:Q16342|ensembl:ENSG00000071994(gene)|ensembl:ENST00000541970(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0019899"(enzyme binding)|refseq:NP_001186392.1|refseq:NP_001186393.1|refseq:NP_001186391.1|refseq:NP_659005.1|dip:DIP-27594N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:/u6RWNsUrEKz5MecLGyv4+elO309606 rogid:I44GXBUa4NByhkP4HQdnUgfkNCs9606 intact-crc:D82E0F9129BB1387|rigid:YpJJ8dfozFePCNm4CCpATa4O/Is false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q70CQ1 uniprotkb:P31948 intact:EBI-2511022|ensembl:ENSP00000377797|ensembl:ENSP00000507239|uniprotkb:Q5T3E0|uniprotkb:Q5T3D9|uniprotkb:Q96CK4 intact:EBI-1054052|uniprotkb:Q5TZU9|intact:EBI-4404694|uniprotkb:B4DM70|uniprotkb:F5H0T1|uniprotkb:G3XAD8|uniprotkb:Q3ZCU9|ensembl:ENSP00000305958 psi-mi:ubp49_human(display_long)|uniprotkb:USP49(gene name)|psi-mi:USP49(display_short)|uniprotkb:Ubiquitin thioesterase 49(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 49(gene name synonym)|uniprotkb:Deubiquitinating enzyme 49(gene name synonym) psi-mi:stip1_human(display_long)|uniprotkb:Hsc70/Hsp90-organizing protein(gene name synonym)|uniprotkb:STIP1(gene name)|psi-mi:STIP1(display_short)|uniprotkb:Transformation-sensitive protein IEF SSP 3521(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-11(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512828|imex:IM-12079-26 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001273483.1|ensembl:ENSG00000164663(gene)|ensembl:ENST00000394253(transcript)|ensembl:ENST00000682992(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035616"(histone H2B conserved C-terminal lysine deubiquitination)|go:"GO:0042393"(histone binding)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|interpro:IPR028889|reactome:R-HSA-5689880|interpro:IPR038765|refseq:NP_061031.2 refseq:NP_006810.1|ensembl:ENSG00000168439(gene)|ensembl:ENST00000305218(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:0101031"(chaperone complex)|go:"GO:0120293"(dynein axonemal particle)|interpro:IPR006636(Heat shock chaperonin-binding)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013105(Tetratricopeptide TPR2)|interpro:IPR019734|interpro:IPR041243|mint:P31948|rcsb pdb:1ELR|rcsb pdb:1ELW|rcsb pdb:2LNI|rcsb pdb:2NC9|rcsb pdb:3ESK|rcsb pdb:3FWV|reactome:R-HSA-3371497|reactome:R-HSA-9696273|refseq:NP_001269581.1|refseq:NP_001269582.1|dip:DIP-41085N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:/u6RWNsUrEKz5MecLGyv4+elO309606 rogid:/encEzabIj7I9YdYaYY2UvRG3Pg9606 intact-crc:D82E0F9129BB1387|rigid:YpJJ8dfozFePCNm4CCpATa4O/Is false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q70CQ1 uniprotkb:Q92504 intact:EBI-2511022|ensembl:ENSP00000377797|ensembl:ENSP00000507239|uniprotkb:Q5T3E0|uniprotkb:Q5T3D9|uniprotkb:Q96CK4 intact:EBI-1051105|uniprotkb:Q5STP8|uniprotkb:Q9UIQ0|uniprotkb:B0UXF6|ensembl:ENSP00000363807|ensembl:ENSP00000363809|ensembl:ENSP00000372700|ensembl:ENSP00000372701|ensembl:ENSP00000389623|ensembl:ENSP00000391735|ensembl:ENSP00000403583|ensembl:ENSP00000407093|ensembl:ENSP00000410656|ensembl:ENSP00000413027|ensembl:ENSP00000414145|ensembl:ENSP00000416439 psi-mi:ubp49_human(display_long)|uniprotkb:USP49(gene name)|psi-mi:USP49(display_short)|uniprotkb:Ubiquitin thioesterase 49(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 49(gene name synonym)|uniprotkb:Deubiquitinating enzyme 49(gene name synonym) psi-mi:s39a7_human(display_long)|uniprotkb:Solute carrier family 39 member 7(gene name synonym)|uniprotkb:Histidine-rich membrane protein Ke4(gene name synonym)|uniprotkb:SLC39A7(gene name)|psi-mi:SLC39A7(display_short)|uniprotkb:HKE4(gene name synonym)|uniprotkb:RING5(gene name synonym)|uniprotkb:Zrt-, Irt-like protein 7(gene name synonym)|uniprotkb:Really interesting new gene 5 protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512828|imex:IM-12079-26 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001273483.1|ensembl:ENSG00000164663(gene)|ensembl:ENST00000394253(transcript)|ensembl:ENST00000682992(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035616"(histone H2B conserved C-terminal lysine deubiquitination)|go:"GO:0042393"(histone binding)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|interpro:IPR028889|reactome:R-HSA-5689880|interpro:IPR038765|refseq:NP_061031.2 refseq:NP_001070984.1|refseq:NP_008910.2|refseq:NP_001275706.1|ensembl:ENSG00000112473(gene)|ensembl:ENSG00000206288(gene)|ensembl:ENSG00000224399(gene)|ensembl:ENSG00000226614(gene)|ensembl:ENSG00000227402(gene)|ensembl:ENSG00000229802(gene)|ensembl:ENST00000374675(transcript)|ensembl:ENST00000374677(transcript)|ensembl:ENST00000383213(transcript)|ensembl:ENST00000383214(transcript)|ensembl:ENST00000416369(transcript)|ensembl:ENST00000418477(transcript)|ensembl:ENST00000423043(transcript)|ensembl:ENST00000441854(transcript)|ensembl:ENST00000441953(transcript)|ensembl:ENST00000443773(transcript)|ensembl:ENST00000456261(transcript)|ensembl:ENST00000431735(transcript)|go:"GO:0005385"(zinc ion transmembrane transporter activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006882"(cellular zinc ion homeostasis)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0071577"(zinc ion transmembrane transport)|interpro:IPR003689(Zinc/iron permease)|mint:Q92504|reactome:R-HSA-442380 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:/u6RWNsUrEKz5MecLGyv4+elO309606 rogid:br+gKDgDx3uyEg/kbJ6JCqJaTXA9606 intact-crc:D82E0F9129BB1387|rigid:YpJJ8dfozFePCNm4CCpATa4O/Is false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q70CQ1 uniprotkb:Q5H9R7 intact:EBI-2511022|ensembl:ENSP00000377797|ensembl:ENSP00000507239|uniprotkb:Q5T3E0|uniprotkb:Q5T3D9|uniprotkb:Q96CK4 intact:EBI-355498|uniprotkb:Q3B7I1|uniprotkb:Q7L4R8|uniprotkb:Q8N3B2|uniprotkb:Q96MB2|uniprotkb:Q9H2K5|uniprotkb:Q9H2K6|uniprotkb:Q9HCL4|uniprotkb:Q9NUY3|uniprotkb:Q3I4Y0|uniprotkb:Q3KR35|uniprotkb:Q68CR3|intact:EBI-28971860|ensembl:ENSP00000377389 psi-mi:ubp49_human(display_long)|uniprotkb:USP49(gene name)|psi-mi:USP49(display_short)|uniprotkb:Ubiquitin thioesterase 49(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 49(gene name synonym)|uniprotkb:Deubiquitinating enzyme 49(gene name synonym) psi-mi:pp6r3_human(display_long)|uniprotkb:PPP6R3(gene name)|psi-mi:PPP6R3(display_short)|uniprotkb:C11orf23(gene name synonym)|uniprotkb:KIAA1558(gene name synonym)|uniprotkb:PP6R3(gene name synonym)|uniprotkb:SAPL(gene name synonym)|uniprotkb:Sporulation-induced transcript 4-associated protein SAPL(gene name synonym)|uniprotkb:SAPS domain family member 3(gene name synonym)|uniprotkb:SAPS3(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512828|imex:IM-12079-26 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001273483.1|ensembl:ENSG00000164663(gene)|ensembl:ENST00000394253(transcript)|ensembl:ENST00000682992(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035616"(histone H2B conserved C-terminal lysine deubiquitination)|go:"GO:0042393"(histone binding)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|interpro:IPR028889|reactome:R-HSA-5689880|interpro:IPR038765|refseq:NP_061031.2 refseq:NP_001157632.1|refseq:NP_001157633.1|refseq:NP_001157634.1|refseq:NP_001157635.1|refseq:NP_001157636.1|refseq:NP_060782.2|ensembl:ENST00000265636|ensembl:ENSP00000265636|ensembl:ENSP00000377389|ensembl:ENST00000393801|ensembl:ENSP00000377390|ensembl:ENST00000524845|ensembl:ENSP00000431415|ensembl:ENST00000524904|ensembl:ENSP00000433058|ensembl:ENST00000529710|ensembl:ENSP00000437329|refseq:XP_011543442.1|refseq:XP_006718676.1|refseq:XP_006718677.1|refseq:XP_006718681.1|refseq:XP_006718687.1|refseq:XP_016873451.1|refseq:XP_016873452.1|refseq:XP_016873455.1|ensembl:ENSG00000110075(gene)|ensembl:ENST00000393800(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|interpro:IPR007587(SIT4 phosphatase-associated protein)|interpro:IPR016024(Armadillo-type fold)|mint:Q5H9R7|reactome:R-HSA-171319|reactome:R-HSA-204005 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:/u6RWNsUrEKz5MecLGyv4+elO309606 rogid:9hU14AmzYI9nORfchfMtLoyRecA9606 intact-crc:D82E0F9129BB1387|rigid:YpJJ8dfozFePCNm4CCpATa4O/Is false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q70CQ1 uniprotkb:O95071 intact:EBI-2511022|ensembl:ENSP00000377797|ensembl:ENSP00000507239|uniprotkb:Q5T3E0|uniprotkb:Q5T3D9|uniprotkb:Q96CK4 intact:EBI-358329|uniprotkb:O94970|uniprotkb:Q9NPL3|ensembl:ENSP00000429084|uniprotkb:B2RP24|intact:EBI-10967451|uniprotkb:J3KMW7 psi-mi:ubp49_human(display_long)|uniprotkb:USP49(gene name)|psi-mi:USP49(display_short)|uniprotkb:Ubiquitin thioesterase 49(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 49(gene name synonym)|uniprotkb:Deubiquitinating enzyme 49(gene name synonym) psi-mi:ubr5_human(display_long)|uniprotkb:UBR5(gene name)|psi-mi:UBR5(display_short)|uniprotkb:HYD(gene name synonym)|uniprotkb:KIAA0896(gene name synonym)|uniprotkb:EDD(gene name synonym)|uniprotkb:EDD1(gene name synonym)|uniprotkb:E3 ubiquitin-protein ligase, HECT domain-containing 1(gene name synonym)|uniprotkb:Hyperplastic discs protein homolog(gene name synonym)|uniprotkb:Progestin-induced protein(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase UBR5(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512828|imex:IM-12079-26 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001273483.1|ensembl:ENSG00000164663(gene)|ensembl:ENST00000394253(transcript)|ensembl:ENST00000682992(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035616"(histone H2B conserved C-terminal lysine deubiquitination)|go:"GO:0042393"(histone binding)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|interpro:IPR028889|reactome:R-HSA-5689880|interpro:IPR038765|refseq:NP_061031.2 refseq:NP_001269802.1|ensembl:ENST00000520539(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034450"(ubiquitin-ubiquitin ligase activity)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050847"(progesterone receptor signaling pathway)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1901315"(negative regulation of histone H2A K63-linked ubiquitination)|ensembl:ENSG00000104517(gene)|go:"GO:2000779"(regulation of double-strand break repair)|go:"GO:2000780"(negative regulation of double-strand break repair)|interpro:IPR000569(HECT)|interpro:IPR002004(Polyadenylate-binding protein/Hyperplastic disc protein)|interpro:IPR003126(Zinc finger, N-recognin)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR024725|interpro:IPR035983|interpro:IPR036053|mint:O95071|rcsb pdb:1I2T|rcsb pdb:2QHO|refseq:NP_056986.2|rcsb pdb:3PT3|dip:DIP-32930N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:/u6RWNsUrEKz5MecLGyv4+elO309606 rogid:5yiXAYJbV4iA8d3btwaVfL7vaik9606 intact-crc:D82E0F9129BB1387|rigid:YpJJ8dfozFePCNm4CCpATa4O/Is false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q70CQ1 uniprotkb:Q9UPN7 intact:EBI-2511022|ensembl:ENSP00000377797|ensembl:ENSP00000507239|uniprotkb:Q5T3E0|uniprotkb:Q5T3D9|uniprotkb:Q96CK4 intact:EBI-359745|uniprotkb:Q2M2H3|uniprotkb:Q504V2|uniprotkb:Q6NVJ6|uniprotkb:Q9BU97|intact:EBI-28973105|ensembl:ENSP00000414202|ensembl:ENSP00000467521 psi-mi:ubp49_human(display_long)|uniprotkb:USP49(gene name)|psi-mi:USP49(display_short)|uniprotkb:Ubiquitin thioesterase 49(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 49(gene name synonym)|uniprotkb:Deubiquitinating enzyme 49(gene name synonym) psi-mi:pp6r1_human(display_long)|uniprotkb:PPP6R1(gene name)|psi-mi:PPP6R1(display_short)|uniprotkb:KIAA1115(gene name synonym)|uniprotkb:PP6R1(gene name synonym)|uniprotkb:SAPS domain family member 1(gene name synonym)|uniprotkb:SAPS1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512828|imex:IM-12079-26 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001273483.1|ensembl:ENSG00000164663(gene)|ensembl:ENST00000394253(transcript)|ensembl:ENST00000682992(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035616"(histone H2B conserved C-terminal lysine deubiquitination)|go:"GO:0042393"(histone binding)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|interpro:IPR028889|reactome:R-HSA-5689880|interpro:IPR038765|refseq:NP_061031.2 refseq:NP_055746.3|ensembl:ENSP00000414202|ensembl:ENSP00000467521|ensembl:ENSG00000105063(gene)|ensembl:ENST00000412770(transcript)|ensembl:ENST00000587283(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|interpro:IPR007587(SIT4 phosphatase-associated protein)|interpro:IPR016024(Armadillo-type fold)|mint:Q9UPN7|reactome:R-HSA-204005|dip:DIP-27589N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:/u6RWNsUrEKz5MecLGyv4+elO309606 rogid:Nab2lMgz1rQizyvjdbMrJUMNB+I9606 intact-crc:D82E0F9129BB1387|rigid:YpJJ8dfozFePCNm4CCpATa4O/Is false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q70CQ1 uniprotkb:Q13601 intact:EBI-2511022|ensembl:ENSP00000377797|ensembl:ENSP00000507239|uniprotkb:Q5T3E0|uniprotkb:Q5T3D9|uniprotkb:Q96CK4 intact:EBI-744525|intact:EBI-28971604|ensembl:ENSP00000229214|uniprotkb:Q8NEA8|uniprotkb:Q8TC37|uniprotkb:Q96AT5|uniprotkb:A0FIK6|uniprotkb:A0JLP0|uniprotkb:B2R989|uniprotkb:E7EUQ0 psi-mi:ubp49_human(display_long)|uniprotkb:USP49(gene name)|psi-mi:USP49(display_short)|uniprotkb:Ubiquitin thioesterase 49(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 49(gene name synonym)|uniprotkb:Deubiquitinating enzyme 49(gene name synonym) psi-mi:krr1_human(display_long)|uniprotkb:HIV-1 Rev-binding protein 2(gene name synonym)|uniprotkb:Rev-interacting protein 1(gene name synonym)|uniprotkb:KRR1(gene name)|psi-mi:KRR1(display_short)|uniprotkb:HRB2(gene name synonym)|uniprotkb:KRR-R motif-containing protein 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512828|imex:IM-12079-26 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001273483.1|ensembl:ENSG00000164663(gene)|ensembl:ENST00000394253(transcript)|ensembl:ENST00000682992(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035616"(histone H2B conserved C-terminal lysine deubiquitination)|go:"GO:0042393"(histone binding)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|interpro:IPR028889|reactome:R-HSA-5689880|interpro:IPR038765|refseq:NP_061031.2 ensembl:ENSP00000229214|ensembl:ENST00000438169|ensembl:ENSP00000411740|ensembl:ENSG00000111615(gene)|ensembl:ENST00000229214(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006364"(rRNA processing)|go:"GO:0016020"(membrane)|go:"GO:0032040"(small-subunit processome)|go:"GO:0045171"(intercellular bridge)|interpro:IPR004087(K Homology)|interpro:IPR024166|interpro:IPR036612|interpro:IPR041174|mint:Q13601|refseq:NP_008974.5|reactome:R-HSA-6790901|reactome:R-HSA-6791226 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:/u6RWNsUrEKz5MecLGyv4+elO309606 rogid:uBKNL/aw4wEssKJulbqQVWcH7ZI9606 intact-crc:D82E0F9129BB1387|rigid:YpJJ8dfozFePCNm4CCpATa4O/Is false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q70CQ1 uniprotkb:Q8NEM2 intact:EBI-2511022|ensembl:ENSP00000377797|ensembl:ENSP00000507239|uniprotkb:Q5T3E0|uniprotkb:Q5T3D9|uniprotkb:Q96CK4 intact:EBI-744700|uniprotkb:Q96N60|uniprotkb:Q9BVS0|uniprotkb:Q9H6P6|ensembl:ENSP00000306473 psi-mi:ubp49_human(display_long)|uniprotkb:USP49(gene name)|psi-mi:USP49(display_short)|uniprotkb:Ubiquitin thioesterase 49(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 49(gene name synonym)|uniprotkb:Deubiquitinating enzyme 49(gene name synonym) psi-mi:shcbp_human(display_long)|uniprotkb:SHCBP1(gene name)|psi-mi:SHCBP1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512828|imex:IM-12079-26 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001273483.1|ensembl:ENSG00000164663(gene)|ensembl:ENST00000394253(transcript)|ensembl:ENST00000682992(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035616"(histone H2B conserved C-terminal lysine deubiquitination)|go:"GO:0042393"(histone binding)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|interpro:IPR028889|reactome:R-HSA-5689880|interpro:IPR038765|refseq:NP_061031.2 refseq:NP_079021.3|ensembl:ENSG00000171241(gene)|ensembl:ENST00000303383(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0030496"(midbody)|go:"GO:2000177"(regulation of neural precursor cell proliferation)|interpro:IPR006626(Parallel beta-helix repeat)|interpro:IPR011050(Pectin lyase fold/virulence factor)|interpro:IPR012334(Pectin lyase fold)|interpro:IPR039448|mint:Q8NEM2 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:/u6RWNsUrEKz5MecLGyv4+elO309606 rogid:VkqhT9kcant5+JwTeubTotVcLfo9606 intact-crc:D82E0F9129BB1387|rigid:YpJJ8dfozFePCNm4CCpATa4O/Is false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q70CQ1 uniprotkb:Q14566 intact:EBI-2511022|ensembl:ENSP00000377797|ensembl:ENSP00000507239|uniprotkb:Q5T3E0|uniprotkb:Q5T3D9|uniprotkb:Q96CK4 intact:EBI-374900|uniprotkb:Q13504|uniprotkb:Q99859|uniprotkb:B2R6H2|ensembl:ENSP00000264156 psi-mi:ubp49_human(display_long)|uniprotkb:USP49(gene name)|psi-mi:USP49(display_short)|uniprotkb:Ubiquitin thioesterase 49(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 49(gene name synonym)|uniprotkb:Deubiquitinating enzyme 49(gene name synonym) psi-mi:mcm6_human(display_long)|uniprotkb:MCM6(gene name)|psi-mi:MCM6(display_short)|uniprotkb:p105MCM(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512828|imex:IM-12079-26 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001273483.1|ensembl:ENSG00000164663(gene)|ensembl:ENST00000394253(transcript)|ensembl:ENST00000682992(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035616"(histone H2B conserved C-terminal lysine deubiquitination)|go:"GO:0042393"(histone binding)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|interpro:IPR028889|reactome:R-HSA-5689880|interpro:IPR038765|refseq:NP_061031.2 ensembl:ENST00000264156(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0042555"(MCM complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0071162"(CMG complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902969"(mitotic DNA replication)|ensembl:ENSG00000076003(gene)|reactome:R-HSA-68962|reactome:R-HSA-69052|interpro:IPR008049(MCM protein 6)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR018525|interpro:IPR027417|interpro:IPR027925|interpro:IPR031327|interpro:IPR033762|interpro:IPR041024|interpro:IPR041562|interpro:IPR001208(MCM)|mint:Q14566|rcsb pdb:2KLQ|rcsb pdb:2LE8|rcsb pdb:6XTX|rcsb pdb:6XTY|reactome:R-HSA-176187|reactome:R-HSA-176974|reactome:R-HSA-68867|reactome:R-HSA-68949|refseq:NP_005906.2|dip:DIP-31727N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:/u6RWNsUrEKz5MecLGyv4+elO309606 rogid:gVpEwgfSwwxvP2T2CvCzIukthY49606 intact-crc:D82E0F9129BB1387|rigid:YpJJ8dfozFePCNm4CCpATa4O/Is false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q70CQ1 uniprotkb:Q9Y2Z4 intact:EBI-2511022|ensembl:ENSP00000377797|ensembl:ENSP00000507239|uniprotkb:Q5T3E0|uniprotkb:Q5T3D9|uniprotkb:Q96CK4 intact:EBI-1049286|uniprotkb:Q9H817|uniprotkb:D3DUW8|ensembl:ENSP00000320658 psi-mi:ubp49_human(display_long)|uniprotkb:USP49(gene name)|psi-mi:USP49(display_short)|uniprotkb:Ubiquitin thioesterase 49(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 49(gene name synonym)|uniprotkb:Deubiquitinating enzyme 49(gene name synonym) psi-mi:syym_human(display_long)|uniprotkb:YARS2(gene name)|psi-mi:YARS2(display_short)|uniprotkb:Tyrosyl-tRNA synthetase(gene name synonym)|uniprotkb:CGI-04(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512828|imex:IM-12079-26 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001273483.1|ensembl:ENSG00000164663(gene)|ensembl:ENST00000394253(transcript)|ensembl:ENST00000682992(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035616"(histone H2B conserved C-terminal lysine deubiquitination)|go:"GO:0042393"(histone binding)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|interpro:IPR028889|reactome:R-HSA-5689880|interpro:IPR038765|refseq:NP_061031.2 refseq:NP_001035526.1|ensembl:ENSG00000139131(gene)|ensembl:ENST00000324868(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004831"(tyrosine-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006412"(translation)|go:"GO:0016604"(nuclear body)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043039"(tRNA aminoacylation)|go:"GO:0070184"(mitochondrial tyrosyl-tRNA aminoacylation)|go:"GO:0072545"(tyrosine binding)|interpro:IPR001412(Aminoacyl-tRNA synthetase, class I, conserved site)|interpro:IPR002305(Aminoacyl-tRNA synthetase, class Ib)|interpro:IPR002307(Tyrosyl-tRNA synthetase, class Ib, bacterial/mitochondrial)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR024088|interpro:IPR036986|rcsb pdb:2PID|rcsb pdb:3ZXI|reactome:R-HSA-379726|dip:DIP-29487N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:/u6RWNsUrEKz5MecLGyv4+elO309606 rogid:cTNOZVenqyzWUlHTF7XLcZIKV+s9606 intact-crc:D82E0F9129BB1387|rigid:YpJJ8dfozFePCNm4CCpATa4O/Is false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q70CQ1 uniprotkb:O15182 intact:EBI-2511022|ensembl:ENSP00000377797|ensembl:ENSP00000507239|uniprotkb:Q5T3E0|uniprotkb:Q5T3D9|uniprotkb:Q96CK4 intact:EBI-712959|ensembl:ENSP00000283122|uniprotkb:Q53YD2|uniprotkb:Q9BS23 psi-mi:ubp49_human(display_long)|uniprotkb:USP49(gene name)|psi-mi:USP49(display_short)|uniprotkb:Ubiquitin thioesterase 49(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 49(gene name synonym)|uniprotkb:Deubiquitinating enzyme 49(gene name synonym) psi-mi:cetn3_human(display_long)|uniprotkb:CETN3(gene name)|psi-mi:CETN3(display_short)|uniprotkb:CEN3(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512828|imex:IM-12079-26 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001273483.1|ensembl:ENSG00000164663(gene)|ensembl:ENST00000394253(transcript)|ensembl:ENST00000682992(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035616"(histone H2B conserved C-terminal lysine deubiquitination)|go:"GO:0042393"(histone binding)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|interpro:IPR028889|reactome:R-HSA-5689880|interpro:IPR038765|refseq:NP_061031.2 ensembl:ENST00000283122(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0007098"(centrosome cycle)|go:"GO:0008017"(microtubule binding)|go:"GO:0015031"(protein transport)|go:"GO:0031683"(G-protein beta/gamma-subunit complex binding)|go:"GO:0032391"(photoreceptor connecting cilium)|go:"GO:0036064"(ciliary basal body)|go:"GO:0044615"(nuclear pore nuclear basket)|go:"GO:0051028"(mRNA transport)|ensembl:ENSG00000153140(gene)|go:"GO:0051301"(cell division)|go:"GO:0070390"(transcription export complex 2)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|refseq:NP_004356.2|refseq:NP_001284697.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:/u6RWNsUrEKz5MecLGyv4+elO309606 rogid:m0uBq6ZNOxGDC2kU8i8rDRlVS6s9606 intact-crc:D82E0F9129BB1387|rigid:YpJJ8dfozFePCNm4CCpATa4O/Is false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q70CQ1 uniprotkb:P41208 intact:EBI-2511022|ensembl:ENSP00000377797|ensembl:ENSP00000507239|uniprotkb:Q5T3E0|uniprotkb:Q5T3D9|uniprotkb:Q96CK4 intact:EBI-1789926|uniprotkb:Q53XW1|uniprotkb:B2R4T4|ensembl:ENSP00000359300 psi-mi:ubp49_human(display_long)|uniprotkb:USP49(gene name)|psi-mi:USP49(display_short)|uniprotkb:Ubiquitin thioesterase 49(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 49(gene name synonym)|uniprotkb:Deubiquitinating enzyme 49(gene name synonym) psi-mi:cetn2_human(display_long)|uniprotkb:CETN2(gene name)|psi-mi:CETN2(display_short)|uniprotkb:CALT(gene name synonym)|uniprotkb:CEN2(gene name synonym)|uniprotkb:Caltractin isoform 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512828|imex:IM-12079-26 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001273483.1|ensembl:ENSG00000164663(gene)|ensembl:ENST00000394253(transcript)|ensembl:ENST00000682992(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035616"(histone H2B conserved C-terminal lysine deubiquitination)|go:"GO:0042393"(histone binding)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|interpro:IPR028889|reactome:R-HSA-5689880|interpro:IPR038765|refseq:NP_061031.2 refseq:NP_004335.1|ensembl:ENSG00000147400(gene)|ensembl:ENST00000370277(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0007099"(centriole replication)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008017"(microtubule binding)|go:"GO:0015031"(protein transport)|go:"GO:0031683"(G-protein beta/gamma-subunit complex binding)|go:"GO:0032391"(photoreceptor connecting cilium)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032795"(heterotrimeric G-protein binding)|go:"GO:0036064"(ciliary basal body)|go:"GO:0044615"(nuclear pore nuclear basket)|go:"GO:0045177"(apical part of cell)|go:"GO:0051028"(mRNA transport)|go:"GO:0051301"(cell division)|go:"GO:0070390"(transcription export complex 2)|go:"GO:0071942"(XPC complex)|go:"GO:0097729"(9+2 motile cilium)|interpro:IPR000629(RNA helicase, ATP-dependent, DEAD-box, conserved site)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR037629|rcsb pdb:1M39|rcsb pdb:1ZMZ|rcsb pdb:2A4J|rcsb pdb:2GGM|rcsb pdb:2K2I|rcsb pdb:2OBH|reactome:R-HSA-2565942|reactome:R-HSA-3108214|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-5696394|reactome:R-HSA-5696395|reactome:R-HSA-8854518 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:/u6RWNsUrEKz5MecLGyv4+elO309606 rogid:gOH/cxPm4HW7g94+UYIAAipqXyg9606 intact-crc:D82E0F9129BB1387|rigid:YpJJ8dfozFePCNm4CCpATa4O/Is false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q70CQ1 uniprotkb:Q9H0E7 intact:EBI-2511022|ensembl:ENSP00000377797|ensembl:ENSP00000507239|uniprotkb:Q5T3E0|uniprotkb:Q5T3D9|uniprotkb:Q96CK4 intact:EBI-2512823|ensembl:ENSP00000258499|ensembl:ENSP00000376806|ensembl:ENSP00000442629|uniprotkb:B2RDW3 psi-mi:ubp49_human(display_long)|uniprotkb:USP49(gene name)|psi-mi:USP49(display_short)|uniprotkb:Ubiquitin thioesterase 49(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 49(gene name synonym)|uniprotkb:Deubiquitinating enzyme 49(gene name synonym) psi-mi:ubp44_human(display_long)|uniprotkb:USP44(gene name)|psi-mi:USP44(display_short)|uniprotkb:Ubiquitin-specific-processing protease 44(gene name synonym)|uniprotkb:Deubiquitinating enzyme 44(gene name synonym)|uniprotkb:Ubiquitin thioesterase 44(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512828|imex:IM-12079-26 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001273483.1|ensembl:ENSG00000164663(gene)|ensembl:ENST00000394253(transcript)|ensembl:ENST00000682992(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035616"(histone H2B conserved C-terminal lysine deubiquitination)|go:"GO:0042393"(histone binding)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|interpro:IPR028889|reactome:R-HSA-5689880|interpro:IPR038765|refseq:NP_061031.2 ensembl:ENSG00000136014(gene)|ensembl:ENST00000258499(transcript)|ensembl:ENST00000393091(transcript)|ensembl:ENST00000537435(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0007049"(cell cycle)|go:"GO:0007059"(chromosome segregation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0051301"(cell division)|go:"GO:0090266"(regulation of mitotic cell cycle spindle assembly checkpoint)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|reactome:R-HSA-5689880|refseq:NP_001035862.1|refseq:NP_115523.2|refseq:NP_001334865.1|refseq:NP_001334866.1|refseq:NP_001265322.1|refseq:XP_016875499.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:/u6RWNsUrEKz5MecLGyv4+elO309606 rogid:bLj1vAKvdLEl+jd7n9MMCOKBtco9606 intact-crc:D82E0F9129BB1387|rigid:YpJJ8dfozFePCNm4CCpATa4O/Is false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q70CQ1 uniprotkb:P08709 intact:EBI-2511022|ensembl:ENSP00000377797|ensembl:ENSP00000507239|uniprotkb:Q5T3E0|uniprotkb:Q5T3D9|uniprotkb:Q96CK4 intact:EBI-355972|ensembl:ENSP00000364731|uniprotkb:Q14339|uniprotkb:Q5JVF2|uniprotkb:B0YJC8|uniprotkb:Q5JVF1|uniprotkb:Q9UD52|uniprotkb:Q9UD53|uniprotkb:Q9UD54 psi-mi:ubp49_human(display_long)|uniprotkb:USP49(gene name)|psi-mi:USP49(display_short)|uniprotkb:Ubiquitin thioesterase 49(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 49(gene name synonym)|uniprotkb:Deubiquitinating enzyme 49(gene name synonym) psi-mi:fa7_human(display_long)|uniprotkb:F7(gene name)|psi-mi:F7(display_short)|uniprotkb:Serum prothrombin conversion accelerator(gene name synonym)|uniprotkb:Proconvertin(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512828|imex:IM-12079-26 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001273483.1|ensembl:ENSG00000164663(gene)|ensembl:ENST00000394253(transcript)|ensembl:ENST00000682992(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035616"(histone H2B conserved C-terminal lysine deubiquitination)|go:"GO:0042393"(histone binding)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|interpro:IPR028889|reactome:R-HSA-5689880|interpro:IPR038765|refseq:NP_061031.2 ensembl:ENSG00000057593(gene)|ensembl:ENST00000375581(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002690"(positive regulation of leukocyte chemotaxis)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0007596"(blood coagulation)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0010037"(response to carbon dioxide)|go:"GO:0010641"(positive regulation of platelet-derived growth factor receptor signaling pathway)|go:"GO:0016485"(protein processing)|go:"GO:0030194"(positive regulation of blood coagulation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031982"(vesicle)|go:"GO:0032355"(response to estradiol)|go:"GO:0032571"(response to vitamin K)|go:"GO:0033595"(response to genistein)|go:"GO:0043627"(response to estrogen)|rcsb pdb:1F7M|rcsb pdb:1FAK|rcsb pdb:1FF7|go:"GO:0050927"(positive regulation of positive chemotaxis)|rcsb pdb:1FFM|rcsb pdb:1J9C|rcsb pdb:1JBU|go:"GO:0051897"(positive regulation of protein kinase B signaling)|rcsb pdb:1KLI|go:"GO:0060416"(response to growth hormone)|go:"GO:0061476"(response to anticoagulant)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070723"(response to cholesterol)|go:"GO:0097068"(response to thyroxine)|go:"GO:1904400"(response to Thyroid stimulating hormone)|go:"GO:1904612"(response to 2,3,7,8-tetrachlorodibenzodioxine)|go:"GO:1905217"(response to astaxanthin)|go:"GO:1905225"(response to thyrotropin-releasing hormone)|go:"GO:1905286"(serine-type peptidase complex)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000294(Vitamin K-dependent carboxylation/gamma-carboxyglutamic region)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR012224(Peptidase S1A, coagulation factor VII/IX/X/C/Z)|interpro:IPR017857(Coagulation factor, subset, Gla region)|interpro:IPR018097|interpro:IPR018114|interpro:IPR033116|interpro:IPR033190|interpro:IPR035972|interpro:IPR043504|rcsb pdb:1BF9|rcsb pdb:1CVW|rcsb pdb:1DAN|rcsb pdb:1DVA|rcsb pdb:1F7E|rcsb pdb:1KLJ|rcsb pdb:1NL8|rcsb pdb:1O5D|rcsb pdb:1QFK|rcsb pdb:1W0Y|rcsb pdb:1W2K|rcsb pdb:1W7X|rcsb pdb:1W8B|rcsb pdb:1WQV|rcsb pdb:1WSS|rcsb pdb:1WTG|rcsb pdb:1WUN|rcsb pdb:1WV7|rcsb pdb:1YGC|rcsb pdb:1Z6J|rcsb pdb:2A2Q|rcsb pdb:2AEI|rcsb pdb:2AER|rcsb pdb:2B7D|rcsb pdb:2B8O|rcsb pdb:2BZ6|rcsb pdb:2C4F|rcsb pdb:2EC9|rcsb pdb:2F9B|rcsb pdb:2FIR|rcsb pdb:2FLB|rcsb pdb:2FLR|rcsb pdb:2PUQ|refseq:NP_000122.1|refseq:NP_062562.1|rcsb pdb:2ZP0|rcsb pdb:2ZWL|rcsb pdb:2ZZU|rcsb pdb:3ELA|rcsb pdb:3TH2|rcsb pdb:3TH3|rcsb pdb:3TH4|rcsb pdb:4IBL|rcsb pdb:4ISH|rcsb pdb:4ISI|rcsb pdb:4JYU|rcsb pdb:4JYV|rcsb pdb:4JZD|rcsb pdb:4JZE|rcsb pdb:4JZF|rcsb pdb:4NA9|rcsb pdb:4NG9|rcsb pdb:4NGA|rcsb pdb:4X8S|rcsb pdb:4X8T|rcsb pdb:4X8U|rcsb pdb:4X8V|rcsb pdb:4YLQ|rcsb pdb:4YT6|rcsb pdb:4YT7|rcsb pdb:4Z6A|rcsb pdb:4ZMA|rcsb pdb:4ZXX|rcsb pdb:4ZXY|rcsb pdb:5I46|rcsb pdb:5L0S|rcsb pdb:5L2Y|rcsb pdb:5L2Z|rcsb pdb:5L30|rcsb pdb:5PA8|rcsb pdb:5PA9|rcsb pdb:5PAA|rcsb pdb:5PAB|rcsb pdb:5PAC|rcsb pdb:5PAE|rcsb pdb:5PAF|rcsb pdb:5PAG|rcsb pdb:5PAI|rcsb pdb:5PAJ|rcsb pdb:5PAK|rcsb pdb:5PAM|rcsb pdb:5PAN|rcsb pdb:5PAO|rcsb pdb:5PAQ|rcsb pdb:5PAR|rcsb pdb:5PAS|rcsb pdb:5PAT|rcsb pdb:5PAU|rcsb pdb:5PAV|rcsb pdb:5PAW|rcsb pdb:5PAX|rcsb pdb:5PAY|rcsb pdb:5PB0|rcsb pdb:5PB1|rcsb pdb:5PB2|rcsb pdb:5PB3|rcsb pdb:5PB4|rcsb pdb:5PB5|rcsb pdb:5PB6|rcsb pdb:5TQE|rcsb pdb:5TQF|rcsb pdb:5TQG|rcsb pdb:5U6J|reactome:R-HSA-1368108|reactome:R-HSA-140834|reactome:R-HSA-159740|reactome:R-HSA-159763|reactome:R-HSA-159782|dip:DIP-6135N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:/u6RWNsUrEKz5MecLGyv4+elO309606 rogid:3AajTD0zonhwhwLyNtQ1rIKrgRI9606 intact-crc:D82E0F9129BB1387|rigid:YpJJ8dfozFePCNm4CCpATa4O/Is false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q70CQ1 uniprotkb:Q13451 intact:EBI-2511022|ensembl:ENSP00000377797|ensembl:ENSP00000507239|uniprotkb:Q5T3E0|uniprotkb:Q5T3D9|uniprotkb:Q96CK4 intact:EBI-306914|ensembl:ENSP00000349811|ensembl:ENSP00000441205|ensembl:ENSP00000444810|uniprotkb:Q5TGM6|uniprotkb:F5H7R1|uniprotkb:Q59EB8 psi-mi:ubp49_human(display_long)|uniprotkb:USP49(gene name)|psi-mi:USP49(display_short)|uniprotkb:Ubiquitin thioesterase 49(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 49(gene name synonym)|uniprotkb:Deubiquitinating enzyme 49(gene name synonym) psi-mi:fkbp5_human(display_long)|uniprotkb:FKBP5(gene name)|psi-mi:FKBP5(display_short)|uniprotkb:AIG6(gene name synonym)|uniprotkb:FKBP51(gene name synonym)|uniprotkb:FK506-binding protein 5(gene name synonym)|uniprotkb:51 kDa FK506-binding protein(gene name synonym)|uniprotkb:Rotamase(gene name synonym)|uniprotkb:54 kDa progesterone receptor-associated immunophilin(gene name synonym)|uniprotkb:FKBP54(gene name synonym)|uniprotkb:FF1 antigen(gene name synonym)|uniprotkb:HSP90-binding immunophilin(gene name synonym)|uniprotkb:Androgen-regulated protein 6(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512828|imex:IM-12079-26 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001273483.1|ensembl:ENSG00000164663(gene)|ensembl:ENST00000394253(transcript)|ensembl:ENST00000682992(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035616"(histone H2B conserved C-terminal lysine deubiquitination)|go:"GO:0042393"(histone binding)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|interpro:IPR028889|reactome:R-HSA-5689880|interpro:IPR038765|refseq:NP_061031.2 ensembl:ENSG00000096060(gene)|ensembl:ENST00000357266(transcript)|ensembl:ENST00000536438(transcript)|ensembl:ENST00000539068(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005528"(FK506 binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0009617"(response to bacterium)|go:"GO:0016020"(membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|refseq:NP_001139247.1|refseq:NP_001139248.1|refseq:NP_004108.1|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR031210|mint:Q13451|rcsb pdb:1KT0|rcsb pdb:3O5D|rcsb pdb:3O5E|rcsb pdb:3O5F|rcsb pdb:3O5G|rcsb pdb:3O5I|rcsb pdb:3O5J|rcsb pdb:3O5K|rcsb pdb:3O5L|rcsb pdb:3O5M|rcsb pdb:3O5O|rcsb pdb:3O5P|rcsb pdb:3O5Q|rcsb pdb:3O5R|rcsb pdb:4DRH|rcsb pdb:4DRI|rcsb pdb:4DRK|rcsb pdb:4DRM|rcsb pdb:4DRN|rcsb pdb:4DRO|rcsb pdb:4DRP|rcsb pdb:4DRQ|rcsb pdb:4JFI|rcsb pdb:4JFJ|rcsb pdb:4JFK|rcsb pdb:4JFL|rcsb pdb:4JFM|rcsb pdb:4R0X|rcsb pdb:4TW6|rcsb pdb:4TW7|rcsb pdb:4TX0|rcsb pdb:4W9O|rcsb pdb:4W9P|rcsb pdb:4W9Q|rcsb pdb:5BXJ|rcsb pdb:5DIT|rcsb pdb:5DIU|rcsb pdb:5DIV|rcsb pdb:5NJX|rcsb pdb:5OBK|rcsb pdb:5OMP|rcsb pdb:6SAF|rcsb pdb:6TX4|rcsb pdb:6TX5|rcsb pdb:6TX6|rcsb pdb:6TX7|rcsb pdb:6TX8|rcsb pdb:6TX9|rcsb pdb:6TXX|rcsb pdb:7A6W|rcsb pdb:7A6X|rcsb pdb:7AOT|rcsb pdb:7AOU|rcsb pdb:7AWF|rcsb pdb:7AWX|rcsb pdb:7B9Y|rcsb pdb:7B9Z|rcsb pdb:7BA0|reactome:R-HSA-3371497|reactome:R-HSA-8939211|reactome:R-HSA-9022699|refseq:NP_001139249.1|dip:DIP-27597N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:/u6RWNsUrEKz5MecLGyv4+elO309606 rogid:m2Bnn01E13sovh3BwG71Pgqjdx89606 intact-crc:D82E0F9129BB1387|rigid:YpJJ8dfozFePCNm4CCpATa4O/Is false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q70CQ1 uniprotkb:P53621 intact:EBI-2511022|ensembl:ENSP00000377797|ensembl:ENSP00000507239|uniprotkb:Q5T3E0|uniprotkb:Q5T3D9|uniprotkb:Q96CK4 intact:EBI-356273|intact:EBI-1188425|uniprotkb:Q5T201|uniprotkb:Q8IXZ9|intact:EBI-2559704|intact:EBI-11576606|ensembl:ENSP00000241704 psi-mi:ubp49_human(display_long)|uniprotkb:USP49(gene name)|psi-mi:USP49(display_short)|uniprotkb:Ubiquitin thioesterase 49(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 49(gene name synonym)|uniprotkb:Deubiquitinating enzyme 49(gene name synonym) psi-mi:copa_human(display_long)|uniprotkb:COPA(gene name)|psi-mi:COPA(display_short)|uniprotkb:Alpha-coat protein(gene name synonym)|uniprotkb:HEP-COP(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512828|imex:IM-12079-26 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001273483.1|ensembl:ENSG00000164663(gene)|ensembl:ENST00000394253(transcript)|ensembl:ENST00000682992(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035616"(histone H2B conserved C-terminal lysine deubiquitination)|go:"GO:0042393"(histone binding)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|interpro:IPR028889|reactome:R-HSA-5689880|interpro:IPR038765|refseq:NP_061031.2 refseq:NP_001091868.1|refseq:NP_004362.2|ensembl:ENSG00000122218(gene)|ensembl:ENST00000241704(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005179"(hormone activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0006891"(intra-Golgi vesicle-mediated transport)|go:"GO:0016020"(membrane)|go:"GO:0030126"(COPI vesicle coat)|go:"GO:0030133"(transport vesicle)|go:"GO:0030157"(pancreatic juice secretion)|go:"GO:0030426"(growth cone)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001680(WD40 repeat)|interpro:IPR006692(Coatomer, WD associated region)|interpro:IPR010714(Coatomer, alpha subunit, C-terminal)|interpro:IPR011048(Cytochrome cd1-nitrite reductase-like, C-terminal haem d1)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016391(Coatomer, alpha subunit)|interpro:IPR019775|interpro:IPR020472|interpro:IPR024977|interpro:IPR036322|mint:P53621|rcsb pdb:6PBG|rcsb pdb:6TZT|rcsb pdb:6U3V|reactome:R-HSA-6807878|reactome:R-HSA-6811434 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:/u6RWNsUrEKz5MecLGyv4+elO309606 rogid:9uP/NS7FjPrGDna1wcNHQy9py6A9606 intact-crc:D82E0F9129BB1387|rigid:YpJJ8dfozFePCNm4CCpATa4O/Is false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q70CQ1 uniprotkb:P04843 intact:EBI-2511022|ensembl:ENSP00000377797|ensembl:ENSP00000507239|uniprotkb:Q5T3E0|uniprotkb:Q5T3D9|uniprotkb:Q96CK4 intact:EBI-355963|ensembl:ENSP00000296255|uniprotkb:D3DNB6|uniprotkb:Q68DT1|uniprotkb:B2R5Z0 psi-mi:ubp49_human(display_long)|uniprotkb:USP49(gene name)|psi-mi:USP49(display_short)|uniprotkb:Ubiquitin thioesterase 49(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 49(gene name synonym)|uniprotkb:Deubiquitinating enzyme 49(gene name synonym) psi-mi:rpn1_human(display_long)|uniprotkb:RPN1(gene name)|psi-mi:RPN1(display_short)|uniprotkb:Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 67 kDa subunit(gene name synonym)|uniprotkb:Ribophorin-1(gene name synonym)|uniprotkb:Ribophorin I(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512828|imex:IM-12079-26 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001273483.1|ensembl:ENSG00000164663(gene)|ensembl:ENST00000394253(transcript)|ensembl:ENST00000682992(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035616"(histone H2B conserved C-terminal lysine deubiquitination)|go:"GO:0042393"(histone binding)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|interpro:IPR028889|reactome:R-HSA-5689880|interpro:IPR038765|refseq:NP_061031.2 ensembl:ENSG00000163902(gene)|ensembl:ENST00000296255(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006487"(protein N-linked glycosylation)|go:"GO:0008250"(oligosaccharyltransferase complex)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0018279"(protein N-linked glycosylation via asparagine)|go:"GO:0042470"(melanosome)|interpro:IPR007676(Ribophorin I)|mint:P04843|rcsb pdb:6S7O|rcsb pdb:6S7T|reactome:R-HSA-1799339|reactome:R-HSA-446203|reactome:R-HSA-9694548|go:"GO:0006464"(cellular protein modification process)|refseq:NP_002941.1|dip:DIP-38152N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:/u6RWNsUrEKz5MecLGyv4+elO309606 rogid:rvQThNB/dCCNR9+IDssZo1qgZUE9606 intact-crc:D82E0F9129BB1387|rigid:YpJJ8dfozFePCNm4CCpATa4O/Is false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q70CQ1 uniprotkb:Q9BW27 intact:EBI-2511022|ensembl:ENSP00000377797|ensembl:ENSP00000507239|uniprotkb:Q5T3E0|uniprotkb:Q5T3D9|uniprotkb:Q96CK4 intact:EBI-716392|intact:EBI-2563151|uniprotkb:Q9H9U1|uniprotkb:Q8NDI4|uniprotkb:B4DMQ3|uniprotkb:B4DPW1|ensembl:ENSP00000245544 psi-mi:ubp49_human(display_long)|uniprotkb:USP49(gene name)|psi-mi:USP49(display_short)|uniprotkb:Ubiquitin thioesterase 49(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 49(gene name synonym)|uniprotkb:Deubiquitinating enzyme 49(gene name synonym) psi-mi:nup85_human(display_long)|uniprotkb:PCNT1(gene name synonym)|uniprotkb:Nucleoporin Nup85(gene name synonym)|uniprotkb:85 kDa nucleoporin(gene name synonym)|uniprotkb:Nucleoporin Nup75(gene name synonym)|uniprotkb:Pericentrin-1(gene name synonym)|uniprotkb:FROUNT(gene name synonym)|uniprotkb:NUP85(gene name)|psi-mi:NUP85(display_short)|uniprotkb:NUP75(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512828|imex:IM-12079-26 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001273483.1|ensembl:ENSG00000164663(gene)|ensembl:ENST00000394253(transcript)|ensembl:ENST00000682992(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035616"(histone H2B conserved C-terminal lysine deubiquitination)|go:"GO:0042393"(histone binding)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|interpro:IPR028889|reactome:R-HSA-5689880|interpro:IPR038765|refseq:NP_061031.2 refseq:NP_079120.1|refseq:NP_001290205.1|ensembl:ENSG00000125450(gene)|ensembl:ENST00000245544(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0006406"(mRNA export from nucleus)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0016020"(membrane)|go:"GO:0017056"(structural constituent of nuclear pore)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0031080"(nuclear pore outer ring)|go:"GO:0031965"(nuclear membrane)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048246"(macrophage chemotaxis)|go:"GO:0072006"(nephron development)|interpro:IPR011502(Nucleoporin, Nup85-like)|mint:Q9BW27|rcsb pdb:5A9Q|reactome:R-HSA-1169408|reactome:R-HSA-141444|reactome:R-HSA-159227|reactome:R-HSA-159230|reactome:R-HSA-159231|reactome:R-HSA-159236|reactome:R-HSA-165054|reactome:R-HSA-168271|reactome:R-HSA-168276|reactome:R-HSA-168325|reactome:R-HSA-168333|reactome:R-HSA-170822|reactome:R-HSA-180746|reactome:R-HSA-180910|reactome:R-HSA-191859|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-3108214|reactome:R-HSA-3232142|reactome:R-HSA-3301854|reactome:R-HSA-3371453|reactome:R-HSA-4085377|reactome:R-HSA-4551638|reactome:R-HSA-4570464|reactome:R-HSA-4615885|reactome:R-HSA-5578749|reactome:R-HSA-5619107|reactome:R-HSA-5663220|reactome:R-HSA-6784531|reactome:R-HSA-68877|reactome:R-HSA-9609690|reactome:R-HSA-9610379|reactome:R-HSA-9615933|reactome:R-HSA-9648025 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:/u6RWNsUrEKz5MecLGyv4+elO309606 rogid:MWeo3e2aXVKhP1gFV8ZZrgyFSeI9606 intact-crc:D82E0F9129BB1387|rigid:YpJJ8dfozFePCNm4CCpATa4O/Is false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q70CQ1 uniprotkb:O75170 intact:EBI-2511022|ensembl:ENSP00000377797|ensembl:ENSP00000507239|uniprotkb:Q5T3E0|uniprotkb:Q5T3D9|uniprotkb:Q96CK4 intact:EBI-359739|uniprotkb:A6PVG3|uniprotkb:Q7Z5G5|uniprotkb:Q9UGB9|uniprotkb:B7Z7T3|uniprotkb:Q5U5P3|uniprotkb:Q7Z2L2|uniprotkb:Q7Z731|intact:EBI-28971113|ensembl:ENSP00000216061 psi-mi:ubp49_human(display_long)|uniprotkb:USP49(gene name)|psi-mi:USP49(display_short)|uniprotkb:Ubiquitin thioesterase 49(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 49(gene name synonym)|uniprotkb:Deubiquitinating enzyme 49(gene name synonym) psi-mi:pp6r2_human(display_long)|uniprotkb:PP6R2(gene name synonym)|uniprotkb:SAPS domain family member 2(gene name synonym)|uniprotkb:PPP6R2(gene name)|psi-mi:PPP6R2(display_short)|uniprotkb:KIAA0685(gene name synonym)|uniprotkb:SAPS2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512828|imex:IM-12079-26 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001273483.1|ensembl:ENSG00000164663(gene)|ensembl:ENST00000394253(transcript)|ensembl:ENST00000682992(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035616"(histone H2B conserved C-terminal lysine deubiquitination)|go:"GO:0042393"(histone binding)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|interpro:IPR028889|reactome:R-HSA-5689880|interpro:IPR038765|refseq:NP_061031.2 refseq:NP_001229827.1|refseq:NP_001229828.1|refseq:NP_001229829.1|refseq:NP_055493.2|ensembl:ENSP00000216061|ensembl:ENST00000359139|ensembl:ENSP00000352051|ensembl:ENST00000395741|ensembl:ENSP00000379090|ensembl:ENST00000395744|ensembl:ENSP00000379093|ensembl:ENST00000612753|ensembl:ENSP00000478417|ensembl:ENSG00000100239(gene)|ensembl:ENST00000216061(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|interpro:IPR007587(SIT4 phosphatase-associated protein)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|refseq:XP_006724497.1|refseq:XP_016884612.1|refseq:XP_016884613.1|refseq:XP_016884617.1|refseq:XP_016884620.1|refseq:XP_016884621.1|dip:DIP-27539N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:/u6RWNsUrEKz5MecLGyv4+elO309606 rogid:DfPIffAldPgUOqg8CaheKSLnQ2E9606 intact-crc:D82E0F9129BB1387|rigid:YpJJ8dfozFePCNm4CCpATa4O/Is false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q70CQ1 uniprotkb:O95373 intact:EBI-2511022|ensembl:ENSP00000377797|ensembl:ENSP00000507239|uniprotkb:Q5T3E0|uniprotkb:Q5T3D9|uniprotkb:Q96CK4 intact:EBI-286735|uniprotkb:A6NNM5|uniprotkb:Q1RMF7|uniprotkb:Q9H177|uniprotkb:Q9NTE3|uniprotkb:B2R786|intact:EBI-28976968|ensembl:ENSP00000369042 psi-mi:ubp49_human(display_long)|uniprotkb:USP49(gene name)|psi-mi:USP49(display_short)|uniprotkb:Ubiquitin thioesterase 49(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 49(gene name synonym)|uniprotkb:Deubiquitinating enzyme 49(gene name synonym) psi-mi:ipo7_human(display_long)|uniprotkb:Ran-binding protein 7(gene name synonym)|uniprotkb:IPO7(gene name)|psi-mi:IPO7(display_short)|uniprotkb:RANBP7(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512828|imex:IM-12079-26 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001273483.1|ensembl:ENSG00000164663(gene)|ensembl:ENST00000394253(transcript)|ensembl:ENST00000682992(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035616"(histone H2B conserved C-terminal lysine deubiquitination)|go:"GO:0042393"(histone binding)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|interpro:IPR028889|reactome:R-HSA-5689880|interpro:IPR038765|refseq:NP_061031.2 ensembl:ENSP00000369042|refseq:NP_006382.1|dip:DIP-32574N|ensembl:ENSG00000205339(gene)|ensembl:ENST00000379719(transcript)|go:"GO:0005215"(transporter activity)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007165"(signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0030695"(GTPase regulator activity)|go:"GO:0031267"(small GTPase binding)|go:"GO:0042393"(histone binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0046332"(SMAD binding)|interpro:IPR001494(Importin-beta, N-terminal)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013713(Exportin, Cse1-like)|interpro:IPR016024(Armadillo-type fold)|mint:O95373 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:/u6RWNsUrEKz5MecLGyv4+elO309606 rogid:aaTn9E3/dTUETnNBYr38fk4ZtDo9606 intact-crc:D82E0F9129BB1387|rigid:YpJJ8dfozFePCNm4CCpATa4O/Is false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q70CQ1 uniprotkb:O15084 intact:EBI-2511022|ensembl:ENSP00000377797|ensembl:ENSP00000507239|uniprotkb:Q5T3E0|uniprotkb:Q5T3D9|uniprotkb:Q96CK4 intact:EBI-359567|uniprotkb:Q6ULS0|uniprotkb:Q6ZT57|uniprotkb:B4DES5|uniprotkb:Q1WWL4|uniprotkb:Q29RW6|uniprotkb:Q3B857|ensembl:ENSP00000382379|ensembl:ENSP00000397341 psi-mi:ubp49_human(display_long)|uniprotkb:USP49(gene name)|psi-mi:USP49(display_short)|uniprotkb:Ubiquitin thioesterase 49(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 49(gene name synonym)|uniprotkb:Deubiquitinating enzyme 49(gene name synonym) psi-mi:anr28_human(display_long)|uniprotkb:ANKRD28(gene name)|psi-mi:ANKRD28(display_short)|uniprotkb:KIAA0379(gene name synonym)|uniprotkb:Ankyrin repeat domain-containing protein 28(gene name synonym)|uniprotkb:Phosphatase interactor targeting protein hnRNP K(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512828|imex:IM-12079-26 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001273483.1|ensembl:ENSG00000164663(gene)|ensembl:ENST00000394253(transcript)|ensembl:ENST00000682992(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035616"(histone H2B conserved C-terminal lysine deubiquitination)|go:"GO:0042393"(histone binding)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|interpro:IPR028889|reactome:R-HSA-5689880|interpro:IPR038765|refseq:NP_061031.2 refseq:NP_001182027.1|refseq:NP_001182028.1|refseq:NP_056014.2|refseq:XP_011531842.1|refseq:XP_005265053.1|refseq:XP_016861515.1|refseq:XP_016861516.1|dip:DIP-27583N|ensembl:ENSG00000206560(gene)|ensembl:ENST00000399451(transcript)|ensembl:ENST00000412318(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR036770|mint:O15084|reactome:R-HSA-171319|reactome:R-HSA-204005 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:/u6RWNsUrEKz5MecLGyv4+elO309606 rogid:YLJtZR7PWrGejJ8EFI093KRtb2Q9606 intact-crc:D82E0F9129BB1387|rigid:YpJJ8dfozFePCNm4CCpATa4O/Is false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q70CQ1 uniprotkb:Q149N8 intact:EBI-2511022|ensembl:ENSP00000377797|ensembl:ENSP00000507239|uniprotkb:Q5T3E0|uniprotkb:Q5T3D9|uniprotkb:Q96CK4 intact:EBI-714105|uniprotkb:Q149N9|uniprotkb:Q5VV79|uniprotkb:Q68DS5|uniprotkb:Q7Z5J5|uniprotkb:Q8IVE8|uniprotkb:Q8IWQ9|uniprotkb:Q8N1S8|uniprotkb:Q8NBR7|ensembl:ENSP00000275233|ensembl:ENSP00000356475 psi-mi:ubp49_human(display_long)|uniprotkb:USP49(gene name)|psi-mi:USP49(display_short)|uniprotkb:Ubiquitin thioesterase 49(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 49(gene name synonym)|uniprotkb:Deubiquitinating enzyme 49(gene name synonym) psi-mi:shprh_human(display_long)|uniprotkb:SNF2, histone-linker, PHD and RING finger domain-containing helicase(gene name synonym)|uniprotkb:SHPRH(gene name)|psi-mi:SHPRH(display_short)|uniprotkb:KIAA2023(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase SHPRH(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512828|imex:IM-12079-26 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001273483.1|ensembl:ENSG00000164663(gene)|ensembl:ENST00000394253(transcript)|ensembl:ENST00000682992(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035616"(histone H2B conserved C-terminal lysine deubiquitination)|go:"GO:0042393"(histone binding)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|interpro:IPR028889|reactome:R-HSA-5689880|interpro:IPR038765|refseq:NP_061031.2 refseq:XP_006715504.1|ensembl:ENSG00000146414(gene)|ensembl:ENST00000275233(transcript)|ensembl:ENST00000367505(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0004386"(helicase activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016787"(hydrolase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070615"|interpro:IPR000330(SNF2-related)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR001965(Zinc finger, PHD-type)|go:"GO:0031625"(ubiquitin protein ligase binding)|interpro:IPR005818(Histone H1/H5)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR017907|interpro:IPR019786|interpro:IPR027417|interpro:IPR036388|interpro:IPR036390|interpro:IPR038718|mint:Q149N8|rcsb pdb:2M85|rcsb pdb:4QN1|reactome:R-HSA-8866654|refseq:NP_001036148.2|refseq:NP_775105.1|dip:DIP-46277N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:/u6RWNsUrEKz5MecLGyv4+elO309606 rogid:WqU1cBAHV1M5PmgDpqRh11/rNmA9606 intact-crc:D82E0F9129BB1387|rigid:YpJJ8dfozFePCNm4CCpATa4O/Is false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q70CQ1 uniprotkb:O15355 intact:EBI-2511022|ensembl:ENSP00000377797|ensembl:ENSP00000507239|uniprotkb:Q5T3E0|uniprotkb:Q5T3D9|uniprotkb:Q96CK4 intact:EBI-725702|ensembl:ENSP00000342778 psi-mi:ubp49_human(display_long)|uniprotkb:USP49(gene name)|psi-mi:USP49(display_short)|uniprotkb:Ubiquitin thioesterase 49(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 49(gene name synonym)|uniprotkb:Deubiquitinating enzyme 49(gene name synonym) psi-mi:ppm1g_human(display_long)|uniprotkb:Protein phosphatase 2C isoform gamma(gene name synonym)|uniprotkb:Protein phosphatase magnesium-dependent 1 gamma(gene name synonym)|uniprotkb:Protein phosphatase 1C(gene name synonym)|uniprotkb:PPM1G(gene name)|psi-mi:PPM1G(display_short)|uniprotkb:PPM1C(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512828|imex:IM-12079-26 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001273483.1|ensembl:ENSG00000164663(gene)|ensembl:ENST00000394253(transcript)|ensembl:ENST00000682992(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035616"(histone H2B conserved C-terminal lysine deubiquitination)|go:"GO:0042393"(histone binding)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|interpro:IPR028889|reactome:R-HSA-5689880|interpro:IPR038765|refseq:NP_061031.2 refseq:NP_817092.1|ensembl:ENST00000344034(transcript)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006470"(protein dephosphorylation)|ensembl:ENSG00000115241(gene)|go:"GO:0016020"(membrane)|go:"GO:0035970"(peptidyl-threonine dephosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0106306"|go:"GO:0106307"|interpro:IPR000222(Protein phosphatase 2C, manganese/magnesium aspartate binding site)|interpro:IPR001932(Protein phosphatase 2C-related)|interpro:IPR015655(Protein phosphatase 2C)|interpro:IPR036457|mint:O15355|dip:DIP-29404N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:/u6RWNsUrEKz5MecLGyv4+elO309606 rogid:j9ut2f7QHVyOtsLuYJ8e2XOP3HE9606 intact-crc:D82E0F9129BB1387|rigid:YpJJ8dfozFePCNm4CCpATa4O/Is false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q70CQ1 uniprotkb:P42704 intact:EBI-2511022|ensembl:ENSP00000377797|ensembl:ENSP00000507239|uniprotkb:Q5T3E0|uniprotkb:Q5T3D9|uniprotkb:Q96CK4 intact:EBI-1050853|uniprotkb:A0PJE3|uniprotkb:A8K1V1|uniprotkb:Q53PC0|uniprotkb:Q53QN7|uniprotkb:Q96D84|uniprotkb:Q6ZUD8|uniprotkb:Q7Z7A6|ensembl:ENSP00000260665 psi-mi:ubp49_human(display_long)|uniprotkb:USP49(gene name)|psi-mi:USP49(display_short)|uniprotkb:Ubiquitin thioesterase 49(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 49(gene name synonym)|uniprotkb:Deubiquitinating enzyme 49(gene name synonym) psi-mi:lpprc_human(display_long)|uniprotkb:130 kDa leucine-rich protein(gene name synonym)|uniprotkb:GP130(gene name synonym)|uniprotkb:LRPPRC(gene name)|psi-mi:LRPPRC(display_short)|uniprotkb:LRP130(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512828|imex:IM-12079-26 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001273483.1|ensembl:ENSG00000164663(gene)|ensembl:ENST00000394253(transcript)|ensembl:ENST00000682992(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035616"(histone H2B conserved C-terminal lysine deubiquitination)|go:"GO:0042393"(histone binding)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|interpro:IPR028889|reactome:R-HSA-5689880|interpro:IPR038765|refseq:NP_061031.2 refseq:NP_573566.2|ensembl:ENSG00000138095(gene)|ensembl:ENST00000260665(transcript)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0000961"(negative regulation of mitochondrial RNA catabolic process)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005640"(nuclear outer membrane)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005874"(microtubule)|go:"GO:0008017"(microtubule binding)|go:"GO:0016020"(membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0047497"(mitochondrion transport along microtubule)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0051028"(mRNA transport)|go:"GO:0070129"(regulation of mitochondrial translation)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR002885(Pentatricopeptide repeat)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR033443|interpro:IPR033490|mint:P42704|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564|dip:DIP-27543N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:/u6RWNsUrEKz5MecLGyv4+elO309606 rogid:U0ERiW4agkBDQ7iWXWgRQxhozkg9606 intact-crc:D82E0F9129BB1387|rigid:YpJJ8dfozFePCNm4CCpATa4O/Is false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q13107 uniprotkb:Q9NPI6 intact:EBI-723290|uniprotkb:O43452|uniprotkb:O43453|uniprotkb:Q08AK8|ensembl:ENSP00000265560|uniprotkb:A8K6Y0|uniprotkb:C9IY91 intact:EBI-374238|ensembl:ENSP00000476386|uniprotkb:B4DHN9|uniprotkb:U3KQM8 psi-mi:ubp4_human(display_long)|uniprotkb:Ubiquitin-specific-processing protease 4(gene name synonym)|uniprotkb:Deubiquitinating enzyme 4(gene name synonym)|uniprotkb:Ubiquitous nuclear protein homolog(gene name synonym)|uniprotkb:USP4(gene name)|psi-mi:USP4(display_short)|uniprotkb:UNP(gene name synonym)|uniprotkb:UNPH(gene name synonym)|uniprotkb:Ubiquitin thioesterase 4(gene name synonym) psi-mi:dcp1a_human(display_long)|uniprotkb:DCP1A(gene name)|psi-mi:DCP1A(display_short)|uniprotkb:Transcription factor SMIF(gene name synonym)|uniprotkb:Smad4-interacting transcriptional co-activator(gene name synonym)|uniprotkb:SMIF(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512900|imex:IM-12079-77 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003354.2|refseq:NP_955475.1|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031685"(adenosine receptor binding)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR018200|interpro:IPR028135|interpro:IPR028889|interpro:IPR035927|interpro:IPR038765|mint:Q13107|rcsb pdb:2Y6E|rcsb pdb:5CTR|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5689880|ensembl:ENSG00000114316(gene)|ensembl:ENST00000265560(transcript)|go:"GO:0000244"(spliceosomal tri-snRNP complex assembly)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0031397"(negative regulation of protein ubiquitination)|refseq:NP_001238806.1 ensembl:ENSG00000272886(gene)|ensembl:ENST00000610213(transcript)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0000290"(deadenylation-dependent decapping of nuclear-transcribed mRNA)|go:"GO:0000932"(P-body)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0016020"(membrane)|go:"GO:0016787"(hydrolase activity)|go:"GO:0019894"(kinesin binding)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0031087"(deadenylation-independent decapping of nuclear-transcribed mRNA)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:1903608"(protein localization to cytoplasmic stress granule)|interpro:IPR010334(Dcp1-like decapping)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR031953|mint:Q9NPI6|rcsb pdb:2WX3|rcsb pdb:4B6H|reactome:R-HSA-430039|reactome:R-HSA-450385|reactome:R-HSA-450513|reactome:R-HSA-975957|refseq:NP_060873.4|refseq:NP_001277133.1|refseq:NP_001277136.1|refseq:NP_001277134.1|refseq:NP_001277135.1|dip:DIP-31292N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/09/18 rogid:uVbfLYa5ruPa6HBQehcQfXqI22w9606 rogid:KIg2pPmAEIiig2SXAJNziN91oCY9606 intact-crc:459DCCDBCE9031A4|rigid:xZ+7gpArwPK/H0YI4PMvpKSNG9Q false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q13107 uniprotkb:Q4VC15 intact:EBI-723290|uniprotkb:O43452|uniprotkb:O43453|uniprotkb:Q08AK8|ensembl:ENSP00000265560|uniprotkb:A8K6Y0|uniprotkb:C9IY91 intact:EBI-2512907 psi-mi:ubp4_human(display_long)|uniprotkb:Ubiquitin-specific-processing protease 4(gene name synonym)|uniprotkb:Deubiquitinating enzyme 4(gene name synonym)|uniprotkb:Ubiquitous nuclear protein homolog(gene name synonym)|uniprotkb:USP4(gene name)|psi-mi:USP4(display_short)|uniprotkb:UNP(gene name synonym)|uniprotkb:UNPH(gene name synonym)|uniprotkb:Ubiquitin thioesterase 4(gene name synonym) psi-mi:q4vc15_human(display_long)|uniprotkb:USP32(gene name)|psi-mi:USP32(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512900|imex:IM-12079-77 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003354.2|refseq:NP_955475.1|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031685"(adenosine receptor binding)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR018200|interpro:IPR028135|interpro:IPR028889|interpro:IPR035927|interpro:IPR038765|mint:Q13107|rcsb pdb:2Y6E|rcsb pdb:5CTR|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5689880|ensembl:ENSG00000114316(gene)|ensembl:ENST00000265560(transcript)|go:"GO:0000244"(spliceosomal tri-snRNP complex assembly)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0031397"(negative regulation of protein ubiquitination)|refseq:NP_001238806.1 go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|interpro:IPR028889|interpro:IPR038765|interpro:IPR018200|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2) psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/09/18 rogid:uVbfLYa5ruPa6HBQehcQfXqI22w9606 rogid:Iq+yjhMHrBz6xixWO0jp5YevV6E9606 intact-crc:459DCCDBCE9031A4|rigid:xZ+7gpArwPK/H0YI4PMvpKSNG9Q false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q13107 uniprotkb:Q7L2J0 intact:EBI-723290|uniprotkb:O43452|uniprotkb:O43453|uniprotkb:Q08AK8|ensembl:ENSP00000265560|uniprotkb:A8K6Y0|uniprotkb:C9IY91 intact:EBI-2371983|uniprotkb:Q9NPD4|uniprotkb:B3KP86|uniprotkb:D6W5V7|ensembl:ENSP00000308546 psi-mi:ubp4_human(display_long)|uniprotkb:Ubiquitin-specific-processing protease 4(gene name synonym)|uniprotkb:Deubiquitinating enzyme 4(gene name synonym)|uniprotkb:Ubiquitous nuclear protein homolog(gene name synonym)|uniprotkb:USP4(gene name)|psi-mi:USP4(display_short)|uniprotkb:UNP(gene name synonym)|uniprotkb:UNPH(gene name synonym)|uniprotkb:Ubiquitin thioesterase 4(gene name synonym) psi-mi:mepce_human(display_long)|uniprotkb:MEPCE(gene name)|psi-mi:MEPCE(display_short)|uniprotkb:BCDIN3(gene name synonym)|uniprotkb:Bicoid-interacting protein 3 homolog(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512900|imex:IM-12079-77 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003354.2|refseq:NP_955475.1|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031685"(adenosine receptor binding)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR018200|interpro:IPR028135|interpro:IPR028889|interpro:IPR035927|interpro:IPR038765|mint:Q13107|rcsb pdb:2Y6E|rcsb pdb:5CTR|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5689880|ensembl:ENSG00000114316(gene)|ensembl:ENST00000265560(transcript)|go:"GO:0000244"(spliceosomal tri-snRNP complex assembly)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0031397"(negative regulation of protein ubiquitination)|refseq:NP_001238806.1 refseq:XP_011514712.1|refseq:NP_001181919.1|refseq:NP_001181920.1|refseq:NP_001181921.1|refseq:NP_062552.2|ensembl:ENSG00000146834(gene)|ensembl:ENST00000310512(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001510"(RNA methylation)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0008171"(O-methyltransferase activity)|go:"GO:0008173"(RNA methyltransferase activity)|go:"GO:0008757"(S-adenosylmethionine-dependent methyltransferase activity)|go:"GO:0016073"(snRNA metabolic process)|go:"GO:0017069"(snRNA binding)|go:"GO:0035562"(negative regulation of chromatin binding)|go:"GO:0040031"(snRNA modification)|go:"GO:0097322"(7SK snRNA binding)|go:"GO:0120259"(7SK snRNP)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1904871"(positive regulation of protein localization to Cajal body)|go:"GO:1905382"(positive regulation of snRNA transcription by RNA polymerase II)|go:"GO:1990276"(RNA 5'-methyltransferase activity)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR010675(Bicoid-interacting 3)|interpro:IPR024160|interpro:IPR025714|interpro:IPR029063|interpro:IPR039772|mint:Q7L2J0|rcsb pdb:5UNA|rcsb pdb:6DCB|rcsb pdb:6DCC psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/09/18 rogid:uVbfLYa5ruPa6HBQehcQfXqI22w9606 rogid:VGhJoO3FD7nsJPVSBsKuKsPJzEM9606 intact-crc:459DCCDBCE9031A4|rigid:xZ+7gpArwPK/H0YI4PMvpKSNG9Q false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q13107 uniprotkb:Q8IZD4 intact:EBI-723290|uniprotkb:O43452|uniprotkb:O43453|uniprotkb:Q08AK8|ensembl:ENSP00000265560|uniprotkb:A8K6Y0|uniprotkb:C9IY91 intact:EBI-521595|ensembl:ENSP00000280665|ensembl:ENSP00000494635|uniprotkb:Q86XH9|uniprotkb:Q96BP8|uniprotkb:Q96MZ8|uniprotkb:B4DRD1 psi-mi:ubp4_human(display_long)|uniprotkb:Ubiquitin-specific-processing protease 4(gene name synonym)|uniprotkb:Deubiquitinating enzyme 4(gene name synonym)|uniprotkb:Ubiquitous nuclear protein homolog(gene name synonym)|uniprotkb:USP4(gene name)|psi-mi:USP4(display_short)|uniprotkb:UNP(gene name synonym)|uniprotkb:UNPH(gene name synonym)|uniprotkb:Ubiquitin thioesterase 4(gene name synonym) psi-mi:dcp1b_human(display_long)|uniprotkb:DCP1B(gene name)|psi-mi:DCP1B(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512900|imex:IM-12079-77 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003354.2|refseq:NP_955475.1|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031685"(adenosine receptor binding)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR018200|interpro:IPR028135|interpro:IPR028889|interpro:IPR035927|interpro:IPR038765|mint:Q13107|rcsb pdb:2Y6E|rcsb pdb:5CTR|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5689880|ensembl:ENSG00000114316(gene)|ensembl:ENST00000265560(transcript)|go:"GO:0000244"(spliceosomal tri-snRNP complex assembly)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0031397"(negative regulation of protein ubiquitination)|refseq:NP_001238806.1 ensembl:ENSG00000151065(gene)|ensembl:ENSG00000284850(gene)|ensembl:ENST00000280665(transcript)|ensembl:ENST00000647122(transcript)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0000290"(deadenylation-dependent decapping of nuclear-transcribed mRNA)|go:"GO:0000932"(P-body)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0016020"(membrane)|go:"GO:0016787"(hydrolase activity)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0031087"(deadenylation-independent decapping of nuclear-transcribed mRNA)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR010334(Dcp1-like decapping)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR031953|mint:Q8IZD4|reactome:R-HSA-430039|refseq:NP_689853.3|dip:DIP-31289N|refseq:XP_011519229.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/09/18 rogid:uVbfLYa5ruPa6HBQehcQfXqI22w9606 rogid:fb+/Ls2ohlQHbAa9FZWzpIAH3sU9606 intact-crc:459DCCDBCE9031A4|rigid:xZ+7gpArwPK/H0YI4PMvpKSNG9Q false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q13107 uniprotkb:O95777 intact:EBI-723290|uniprotkb:O43452|uniprotkb:O43453|uniprotkb:Q08AK8|ensembl:ENSP00000265560|uniprotkb:A8K6Y0|uniprotkb:C9IY91 intact:EBI-347779|ensembl:ENSP00000249299 psi-mi:ubp4_human(display_long)|uniprotkb:Ubiquitin-specific-processing protease 4(gene name synonym)|uniprotkb:Deubiquitinating enzyme 4(gene name synonym)|uniprotkb:Ubiquitous nuclear protein homolog(gene name synonym)|uniprotkb:USP4(gene name)|psi-mi:USP4(display_short)|uniprotkb:UNP(gene name synonym)|uniprotkb:UNPH(gene name synonym)|uniprotkb:Ubiquitin thioesterase 4(gene name synonym) psi-mi:lsm8_human(display_long)|uniprotkb:LSM8(gene name)|psi-mi:LSM8(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512900|imex:IM-12079-77 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003354.2|refseq:NP_955475.1|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031685"(adenosine receptor binding)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR018200|interpro:IPR028135|interpro:IPR028889|interpro:IPR035927|interpro:IPR038765|mint:Q13107|rcsb pdb:2Y6E|rcsb pdb:5CTR|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5689880|ensembl:ENSG00000114316(gene)|ensembl:ENST00000265560(transcript)|go:"GO:0000244"(spliceosomal tri-snRNP complex assembly)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0031397"(negative regulation of protein ubiquitination)|refseq:NP_001238806.1 refseq:NP_057284.1|dip:DIP-31195N|ensembl:ENSG00000128534(gene)|ensembl:ENST00000249299(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005688"(U6 snRNP)|go:"GO:0016070"(RNA metabolic process)|go:"GO:0017070"(U6 snRNA binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071011"(precatalytic spliceosome)|go:"GO:0120115"(Lsm2-8 complex)|interpro:IPR001163(Like-Sm ribonucleoprotein, core)|interpro:IPR010920(Like-Sm ribonucleoprotein-related, core)|interpro:IPR034103|interpro:IPR044642|rcsb pdb:3JCR|rcsb pdb:5O9Z|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6QW6|rcsb pdb:6QX9|rcsb pdb:7ABG|reactome:R-HSA-72163 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/09/18 rogid:uVbfLYa5ruPa6HBQehcQfXqI22w9606 rogid:Kyf8IAEIkbe1s2NnqxqGA1o6BbU9606 intact-crc:459DCCDBCE9031A4|rigid:xZ+7gpArwPK/H0YI4PMvpKSNG9Q false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q13107 uniprotkb:Q9H6E5 intact:EBI-723290|uniprotkb:O43452|uniprotkb:O43453|uniprotkb:Q08AK8|ensembl:ENSP00000265560|uniprotkb:A8K6Y0|uniprotkb:C9IY91 intact:EBI-2511680|ensembl:ENSP00000419607|uniprotkb:Q9H6H7|uniprotkb:Q7L583|uniprotkb:Q2NL65|uniprotkb:A1A527|intact:EBI-2809257|uniprotkb:A8K995 psi-mi:ubp4_human(display_long)|uniprotkb:Ubiquitin-specific-processing protease 4(gene name synonym)|uniprotkb:Deubiquitinating enzyme 4(gene name synonym)|uniprotkb:Ubiquitous nuclear protein homolog(gene name synonym)|uniprotkb:USP4(gene name)|psi-mi:USP4(display_short)|uniprotkb:UNP(gene name synonym)|uniprotkb:UNPH(gene name synonym)|uniprotkb:Ubiquitin thioesterase 4(gene name synonym) psi-mi:stpap_human(display_long)|uniprotkb:TUT1(gene name)|psi-mi:TUT1(display_short)|uniprotkb:RBM21(gene name synonym)|uniprotkb:RNA-binding motif protein 21(gene name synonym)|uniprotkb:U6 snRNA-specific terminal uridylyltransferase 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512900|imex:IM-12079-77 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003354.2|refseq:NP_955475.1|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031685"(adenosine receptor binding)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR018200|interpro:IPR028135|interpro:IPR028889|interpro:IPR035927|interpro:IPR038765|mint:Q13107|rcsb pdb:2Y6E|rcsb pdb:5CTR|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5689880|ensembl:ENSG00000114316(gene)|ensembl:ENST00000265560(transcript)|go:"GO:0000244"(spliceosomal tri-snRNP complex assembly)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0031397"(negative regulation of protein ubiquitination)|refseq:NP_001238806.1 rcsb pdb:5WU6|rcsb pdb:5WU5|ensembl:ENSG00000149016(gene)|ensembl:ENST00000476907(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0004652"(polynucleotide adenylyltransferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006378"(mRNA polyadenylation)|go:"GO:0016180"(snRNA processing)|go:"GO:0016607"(nuclear speck)|go:"GO:0016779"(nucleotidyltransferase activity)|go:"GO:0017070"(U6 snRNA binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0031123"(RNA 3'-end processing)|go:"GO:0034477"(U6 snRNA 3'-end processing)|go:"GO:0046872"(metal ion binding)|go:"GO:0050265"(RNA uridylyltransferase activity)|go:"GO:0098789"(pre-mRNA cleavage required for polyadenylation)|go:"GO:1990817"(RNA adenylyltransferase activity)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR002058(PAP/25A-associated)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034388|interpro:IPR035979|interpro:IPR036236|interpro:IPR043519|mint:Q9H6E5|rcsb pdb:2E5G|rcsb pdb:5WU1|rcsb pdb:5WU2|rcsb pdb:5WU3|rcsb pdb:5WU4|go:"GO:0005730"(nucleolus)|refseq:NP_073741.2|dip:DIP-53651N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/09/18 rogid:uVbfLYa5ruPa6HBQehcQfXqI22w9606 rogid:7Df5H4dyiKBTRo4xiRZGbzGvzbk9606 intact-crc:459DCCDBCE9031A4|rigid:xZ+7gpArwPK/H0YI4PMvpKSNG9Q false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q13107 uniprotkb:O43172 intact:EBI-723290|uniprotkb:O43452|uniprotkb:O43453|uniprotkb:Q08AK8|ensembl:ENSP00000265560|uniprotkb:A8K6Y0|uniprotkb:C9IY91 intact:EBI-718395|uniprotkb:O43445|uniprotkb:O43864|uniprotkb:Q96DG2|uniprotkb:Q96IK4|uniprotkb:Q5T1M8|ensembl:ENSP00000363315 psi-mi:ubp4_human(display_long)|uniprotkb:Ubiquitin-specific-processing protease 4(gene name synonym)|uniprotkb:Deubiquitinating enzyme 4(gene name synonym)|uniprotkb:Ubiquitous nuclear protein homolog(gene name synonym)|uniprotkb:USP4(gene name)|psi-mi:USP4(display_short)|uniprotkb:UNP(gene name synonym)|uniprotkb:UNPH(gene name synonym)|uniprotkb:Ubiquitin thioesterase 4(gene name synonym) psi-mi:prp4_human(display_long)|uniprotkb:U4/U6 snRNP 60 kDa protein(gene name synonym)|uniprotkb:WD splicing factor Prp4(gene name synonym)|uniprotkb:PRP4 homolog(gene name synonym)|uniprotkb:PRPF4(gene name)|psi-mi:PRPF4(display_short)|uniprotkb:PRP4(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512900|imex:IM-12079-77 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003354.2|refseq:NP_955475.1|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031685"(adenosine receptor binding)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR018200|interpro:IPR028135|interpro:IPR028889|interpro:IPR035927|interpro:IPR038765|mint:Q13107|rcsb pdb:2Y6E|rcsb pdb:5CTR|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5689880|ensembl:ENSG00000114316(gene)|ensembl:ENST00000265560(transcript)|go:"GO:0000244"(spliceosomal tri-snRNP complex assembly)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0031397"(negative regulation of protein ubiquitination)|refseq:NP_001238806.1 refseq:NP_004688.2|refseq:NP_001231855.1|ensembl:ENSG00000136875(gene)|ensembl:ENST00000374199(transcript)|go:"GO:0000375"(RNA splicing, via transesterification reactions)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0071001"(U4/U6 snRNP)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0097525"(spliceosomal snRNP complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR014906("Pre-mRNA processing factor 4 (PRP4) like")|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|interpro:IPR015943(WD40/YVTN repeat-like)|go:"GO:0006396"(RNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0015030"(Cajal body)|go:"GO:0016607"(nuclear speck)|go:"GO:0017070"(U6 snRNA binding)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036285|interpro:IPR036322|mint:O43172|rcsb pdb:1MZW|rcsb pdb:3JCR|rcsb pdb:5O9Z|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6QW6|rcsb pdb:6QX9|reactome:R-HSA-72163|go:"GO:0030621"(U4 snRNA binding) psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/09/18 rogid:uVbfLYa5ruPa6HBQehcQfXqI22w9606 rogid:PPTNuhEFj4D+gTv/ctTTMzGmFA09606 intact-crc:459DCCDBCE9031A4|rigid:xZ+7gpArwPK/H0YI4PMvpKSNG9Q false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q13107 uniprotkb:Q9Y4Z0 intact:EBI-723290|uniprotkb:O43452|uniprotkb:O43453|uniprotkb:Q08AK8|ensembl:ENSP00000265560|uniprotkb:A8K6Y0|uniprotkb:C9IY91 intact:EBI-372521|ensembl:ENSP00000469468 psi-mi:ubp4_human(display_long)|uniprotkb:Ubiquitin-specific-processing protease 4(gene name synonym)|uniprotkb:Deubiquitinating enzyme 4(gene name synonym)|uniprotkb:Ubiquitous nuclear protein homolog(gene name synonym)|uniprotkb:USP4(gene name)|psi-mi:USP4(display_short)|uniprotkb:UNP(gene name synonym)|uniprotkb:UNPH(gene name synonym)|uniprotkb:Ubiquitin thioesterase 4(gene name synonym) psi-mi:lsm4_human(display_long)|uniprotkb:Glycine-rich protein(gene name synonym)|uniprotkb:LSM4(gene name)|psi-mi:LSM4(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512900|imex:IM-12079-77 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003354.2|refseq:NP_955475.1|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031685"(adenosine receptor binding)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR018200|interpro:IPR028135|interpro:IPR028889|interpro:IPR035927|interpro:IPR038765|mint:Q13107|rcsb pdb:2Y6E|rcsb pdb:5CTR|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5689880|ensembl:ENSG00000114316(gene)|ensembl:ENST00000265560(transcript)|go:"GO:0000244"(spliceosomal tri-snRNP complex assembly)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0031397"(negative regulation of protein ubiquitination)|refseq:NP_001238806.1 refseq:NP_036453.1|ensembl:ENSG00000130520(gene)|ensembl:ENST00000593829(transcript)|go:"GO:0000387"(spliceosomal snRNP assembly)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000932"(P-body)|go:"GO:0000956"(nuclear-transcribed mRNA catabolic process)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005688"(U6 snRNP)|go:"GO:0005829"(cytosol)|go:"GO:0008380"(RNA splicing)|go:"GO:0016020"(membrane)|go:"GO:0017070"(U6 snRNA binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033962"(P-body assembly)|go:"GO:0042731"(PH domain binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0043005"(neuron projection)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0097526"(spliceosomal tri-snRNP complex)|go:"GO:0120115"(Lsm2-8 complex)|interpro:IPR001163(Like-Sm ribonucleoprotein, core)|interpro:IPR010920(Like-Sm ribonucleoprotein-related, core)|interpro:IPR027141|interpro:IPR034101|rcsb pdb:3JCR|rcsb pdb:5O9Z|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6QW6|rcsb pdb:6QX9|rcsb pdb:7ABG|reactome:R-HSA-430039|reactome:R-HSA-72163|dip:DIP-31209N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/09/18 rogid:uVbfLYa5ruPa6HBQehcQfXqI22w9606 rogid:FlaQveuBbixGvfX47pCm26xscT09606 intact-crc:459DCCDBCE9031A4|rigid:xZ+7gpArwPK/H0YI4PMvpKSNG9Q false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q13107 uniprotkb:P30566 intact:EBI-723290|uniprotkb:O43452|uniprotkb:O43453|uniprotkb:Q08AK8|ensembl:ENSP00000265560|uniprotkb:A8K6Y0|uniprotkb:C9IY91 intact:EBI-2511688|ensembl:ENSP00000485525|uniprotkb:B0QY76|uniprotkb:O75495|uniprotkb:Q5TI34 psi-mi:ubp4_human(display_long)|uniprotkb:Ubiquitin-specific-processing protease 4(gene name synonym)|uniprotkb:Deubiquitinating enzyme 4(gene name synonym)|uniprotkb:Ubiquitous nuclear protein homolog(gene name synonym)|uniprotkb:USP4(gene name)|psi-mi:USP4(display_short)|uniprotkb:UNP(gene name synonym)|uniprotkb:UNPH(gene name synonym)|uniprotkb:Ubiquitin thioesterase 4(gene name synonym) psi-mi:pur8_human(display_long)|uniprotkb:ADSL(gene name)|psi-mi:ADSL(display_short)|uniprotkb:AMPS(gene name synonym)|uniprotkb:Adenylosuccinase(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512900|imex:IM-12079-77 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003354.2|refseq:NP_955475.1|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031685"(adenosine receptor binding)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR018200|interpro:IPR028135|interpro:IPR028889|interpro:IPR035927|interpro:IPR038765|mint:Q13107|rcsb pdb:2Y6E|rcsb pdb:5CTR|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5689880|ensembl:ENSG00000114316(gene)|ensembl:ENST00000265560(transcript)|go:"GO:0000244"(spliceosomal tri-snRNP complex assembly)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0031397"(negative regulation of protein ubiquitination)|refseq:NP_001238806.1 go:"GO:0014850"(response to muscle activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042594"(response to starvation)|go:"GO:0042802"(identical protein binding)|go:"GO:0044208"('de novo' AMP biosynthetic process)|go:"GO:0070626"("(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido) succinate lyase (fumarate-forming) activity")|ensembl:ENSG00000239900(gene)|ensembl:ENST00000623063(transcript)|interpro:IPR000362(Fumarate lyase)|interpro:IPR004769(Adenylosuccinate lyase)|interpro:IPR008948(L-Aspartase-like)|interpro:IPR019468|interpro:IPR020557|interpro:IPR022761|rcsb pdb:2J91|rcsb pdb:2VD6|rcsb pdb:4FFX|rcsb pdb:4FLC|reactome:R-HSA-73817|go:"GO:0001666"(response to hypoxia)|go:"GO:0004018"("N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity")|go:"GO:0005829"(cytosol)|go:"GO:0006164"(purine nucleotide biosynthetic process)|go:"GO:0006167"(AMP biosynthetic process)|go:"GO:0006189"('de novo' IMP biosynthetic process)|go:"GO:0007584"(response to nutrient)|go:"GO:0009060"(aerobic respiration)|refseq:NP_000017.1|refseq:NP_001116850.1|refseq:NP_001304852.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/09/18 rogid:uVbfLYa5ruPa6HBQehcQfXqI22w9606 rogid:yBhDdHJgZN1NJDpN2ivKLI4oUG09606 intact-crc:459DCCDBCE9031A4|rigid:xZ+7gpArwPK/H0YI4PMvpKSNG9Q false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q13107 uniprotkb:P62312 intact:EBI-723290|uniprotkb:O43452|uniprotkb:O43453|uniprotkb:Q08AK8|ensembl:ENSP00000265560|uniprotkb:A8K6Y0|uniprotkb:C9IY91 intact:EBI-373310|uniprotkb:Q9Y4Y8|uniprotkb:Q4W5J5|ensembl:ENSP00000296581|ensembl:ENSP00000420929|ensembl:ENSP00000422392|ensembl:ENSP00000427036|ensembl:ENSP00000497311 psi-mi:ubp4_human(display_long)|uniprotkb:Ubiquitin-specific-processing protease 4(gene name synonym)|uniprotkb:Deubiquitinating enzyme 4(gene name synonym)|uniprotkb:Ubiquitous nuclear protein homolog(gene name synonym)|uniprotkb:USP4(gene name)|psi-mi:USP4(display_short)|uniprotkb:UNP(gene name synonym)|uniprotkb:UNPH(gene name synonym)|uniprotkb:Ubiquitin thioesterase 4(gene name synonym) psi-mi:lsm6_human(display_long)|uniprotkb:LSM6(gene name)|psi-mi:LSM6(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512900|imex:IM-12079-77 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003354.2|refseq:NP_955475.1|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031685"(adenosine receptor binding)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR018200|interpro:IPR028135|interpro:IPR028889|interpro:IPR035927|interpro:IPR038765|mint:Q13107|rcsb pdb:2Y6E|rcsb pdb:5CTR|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5689880|ensembl:ENSG00000114316(gene)|ensembl:ENST00000265560(transcript)|go:"GO:0000244"(spliceosomal tri-snRNP complex assembly)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0031397"(negative regulation of protein ubiquitination)|refseq:NP_001238806.1 refseq:NP_009011.1|ensembl:ENSG00000164167(gene)|ensembl:ENST00000296581(transcript)|ensembl:ENST00000502781(transcript)|ensembl:ENST00000504181(transcript)|ensembl:ENST00000515311(transcript)|ensembl:ENST00000649747(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000932"(P-body)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005688"(U6 snRNP)|go:"GO:0005730"(nucleolus)|go:"GO:0005732"("sno(s)RNA-containing ribonucleoprotein complex")|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006402"(mRNA catabolic process)|go:"GO:0008033"(tRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0030490"(maturation of SSU-rRNA)|go:"GO:0030532"(small nuclear ribonucleoprotein complex)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0120115"(Lsm2-8 complex)|interpro:IPR001163(Like-Sm ribonucleoprotein, core)|interpro:IPR010920(Like-Sm ribonucleoprotein-related, core)|interpro:IPR016487(Small nuclear ribonucleoprotein SmF)|mint:P62312|rcsb pdb:3JCR|rcsb pdb:5O9Z|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6QW6|rcsb pdb:6QX9|rcsb pdb:7ABG|reactome:R-HSA-430039|reactome:R-HSA-72163|refseq:XP_016863161.1|refseq:XP_016863162.1|dip:DIP-31128N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/09/18 rogid:uVbfLYa5ruPa6HBQehcQfXqI22w9606 rogid:knWeW+soIyeLSg0Xbe79er748hE9606 intact-crc:459DCCDBCE9031A4|rigid:xZ+7gpArwPK/H0YI4PMvpKSNG9Q false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q13107 uniprotkb:Q96F86 intact:EBI-723290|uniprotkb:O43452|uniprotkb:O43453|uniprotkb:Q08AK8|ensembl:ENSP00000265560|uniprotkb:A8K6Y0|uniprotkb:C9IY91 intact:EBI-997311|uniprotkb:Q9H797|uniprotkb:B3KPH0|uniprotkb:D3DW61|ensembl:ENSP00000497737|ensembl:ENSP00000320503|ensembl:ENSP00000401343|ensembl:ENSP00000455580 psi-mi:ubp4_human(display_long)|uniprotkb:Ubiquitin-specific-processing protease 4(gene name synonym)|uniprotkb:Deubiquitinating enzyme 4(gene name synonym)|uniprotkb:Ubiquitous nuclear protein homolog(gene name synonym)|uniprotkb:USP4(gene name)|psi-mi:USP4(display_short)|uniprotkb:UNP(gene name synonym)|uniprotkb:UNPH(gene name synonym)|uniprotkb:Ubiquitin thioesterase 4(gene name synonym) psi-mi:edc3_human(display_long)|uniprotkb:YjeF domain-containing protein 1(gene name synonym)|uniprotkb:LSM16 homolog(gene name synonym)|uniprotkb:EDC3(gene name)|psi-mi:EDC3(display_short)|uniprotkb:PP844(orf name)|uniprotkb:LSM16(gene name synonym)|uniprotkb:YJDC(gene name synonym)|uniprotkb:YJEFN2(gene name synonym)|uniprotkb:YjeF N-terminal domain-containing protein 2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512900|imex:IM-12079-77 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003354.2|refseq:NP_955475.1|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031685"(adenosine receptor binding)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR018200|interpro:IPR028135|interpro:IPR028889|interpro:IPR035927|interpro:IPR038765|mint:Q13107|rcsb pdb:2Y6E|rcsb pdb:5CTR|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5689880|ensembl:ENSG00000114316(gene)|ensembl:ENST00000265560(transcript)|go:"GO:0000244"(spliceosomal tri-snRNP complex assembly)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0031397"(negative regulation of protein ubiquitination)|refseq:NP_001238806.1 refseq:NP_001135915.1|refseq:NP_001135916.1|refseq:NP_079359.2|ensembl:ENST00000315127(transcript)|ensembl:ENST00000426797(transcript)|ensembl:ENST00000568176(transcript)|ensembl:ENST00000647659(transcript)|go:"GO:0000932"(P-body)|go:"GO:0003729"(mRNA binding)|go:"GO:0005829"(cytosol)|go:"GO:0016020"(membrane)|go:"GO:0031087"(deadenylation-independent decapping of nuclear-transcribed mRNA)|go:"GO:0033962"(P-body assembly)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:1990174"(phosphodiesterase decapping endonuclease activity)|interpro:IPR004443(YjeF-related protein, N-terminal)|interpro:IPR019050|interpro:IPR025609|interpro:IPR025762|interpro:IPR034107|interpro:IPR036652|mint:Q96F86|rcsb pdb:2VC8|rcsb pdb:2WAX|rcsb pdb:2WAY|rcsb pdb:3D3J|rcsb pdb:3D3K|rcsb pdb:6S8S|reactome:R-HSA-430039|ensembl:ENSG00000179151(gene)|dip:DIP-35516N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/09/18 rogid:uVbfLYa5ruPa6HBQehcQfXqI22w9606 rogid:AFS114ghTqHNid3eOFB7iQsfwAg9606 intact-crc:459DCCDBCE9031A4|rigid:xZ+7gpArwPK/H0YI4PMvpKSNG9Q false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q13107 uniprotkb:O60573 intact:EBI-723290|uniprotkb:O43452|uniprotkb:O43453|uniprotkb:Q08AK8|ensembl:ENSP00000265560|uniprotkb:A8K6Y0|uniprotkb:C9IY91 intact:EBI-398610|uniprotkb:O75349|uniprotkb:B8ZZJ9|ensembl:ENSP00000258416 psi-mi:ubp4_human(display_long)|uniprotkb:Ubiquitin-specific-processing protease 4(gene name synonym)|uniprotkb:Deubiquitinating enzyme 4(gene name synonym)|uniprotkb:Ubiquitous nuclear protein homolog(gene name synonym)|uniprotkb:USP4(gene name)|psi-mi:USP4(display_short)|uniprotkb:UNP(gene name synonym)|uniprotkb:UNPH(gene name synonym)|uniprotkb:Ubiquitin thioesterase 4(gene name synonym) psi-mi:if4e2_human(display_long)|uniprotkb:EIF4E2(gene name)|psi-mi:EIF4E2(display_short)|uniprotkb:mRNA cap-binding protein type 3(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 4E-like 3(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 4E homologous protein(gene name synonym)|uniprotkb:mRNA cap-binding protein 4EHP(gene name synonym)|uniprotkb:eIF4E-like protein 4E-LP(gene name synonym)|uniprotkb:EIF4EL3(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512900|imex:IM-12079-77 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003354.2|refseq:NP_955475.1|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031685"(adenosine receptor binding)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR018200|interpro:IPR028135|interpro:IPR028889|interpro:IPR035927|interpro:IPR038765|mint:Q13107|rcsb pdb:2Y6E|rcsb pdb:5CTR|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5689880|ensembl:ENSG00000114316(gene)|ensembl:ENST00000265560(transcript)|go:"GO:0000244"(spliceosomal tri-snRNP complex assembly)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0031397"(negative regulation of protein ubiquitination)|refseq:NP_001238806.1 refseq:NP_004837.1|dip:DIP-32578N|ensembl:ENSG00000135930(gene)|ensembl:ENST00000258416(transcript)|go:"GO:0000339"(RNA cap binding)|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000932"(P-body)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0008135"(translation factor activity, RNA binding)|go:"GO:0016281"(eukaryotic translation initiation factor 4F complex)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|interpro:IPR001040("Eukaryotic translation initiation factor 4E (eIF-4E)")|interpro:IPR019770|interpro:IPR023398|mint:O60573|rcsb pdb:2JGB|rcsb pdb:2JGC|rcsb pdb:5NVK|rcsb pdb:5NVL|rcsb pdb:5NVM|rcsb pdb:5NVN|rcsb pdb:5XLN|reactome:R-HSA-1169408|refseq:NP_001263265.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/09/18 rogid:uVbfLYa5ruPa6HBQehcQfXqI22w9606 rogid:fjre85PBJjEPNVrWjFUUX5NeuEE9606 intact-crc:459DCCDBCE9031A4|rigid:xZ+7gpArwPK/H0YI4PMvpKSNG9Q false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q13107 uniprotkb:Q9Y333 intact:EBI-723290|uniprotkb:O43452|uniprotkb:O43453|uniprotkb:Q08AK8|ensembl:ENSP00000265560|uniprotkb:A8K6Y0|uniprotkb:C9IY91 intact:EBI-347416|uniprotkb:Q6FGG1|ensembl:ENSP00000414006|ensembl:ENSP00000414634|ensembl:ENSP00000406280|ensembl:ENSP00000364813|ensembl:ENSP00000372883|ensembl:ENSP00000403345 psi-mi:ubp4_human(display_long)|uniprotkb:Ubiquitin-specific-processing protease 4(gene name synonym)|uniprotkb:Deubiquitinating enzyme 4(gene name synonym)|uniprotkb:Ubiquitous nuclear protein homolog(gene name synonym)|uniprotkb:USP4(gene name)|psi-mi:USP4(display_short)|uniprotkb:UNP(gene name synonym)|uniprotkb:UNPH(gene name synonym)|uniprotkb:Ubiquitin thioesterase 4(gene name synonym) psi-mi:lsm2_human(display_long)|uniprotkb:LSM2(gene name)|psi-mi:LSM2(display_short)|uniprotkb:C6orf28(gene name synonym)|uniprotkb:G7B(gene name synonym)|uniprotkb:snRNP core Sm-like protein Sm-x5(gene name synonym)|uniprotkb:Small nuclear ribonuclear protein D homolog(gene name synonym)|uniprotkb:Protein G7b(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512900|imex:IM-12079-77 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003354.2|refseq:NP_955475.1|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031685"(adenosine receptor binding)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR018200|interpro:IPR028135|interpro:IPR028889|interpro:IPR035927|interpro:IPR038765|mint:Q13107|rcsb pdb:2Y6E|rcsb pdb:5CTR|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5689880|ensembl:ENSG00000114316(gene)|ensembl:ENST00000265560(transcript)|go:"GO:0000244"(spliceosomal tri-snRNP complex assembly)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0031397"(negative regulation of protein ubiquitination)|refseq:NP_001238806.1 refseq:NP_067000.1|ensembl:ENST00000375661(transcript)|ensembl:ENST00000383391(transcript)|ensembl:ENST00000424975(transcript)|ensembl:ENST00000432122(transcript)|ensembl:ENST00000434125(transcript)|ensembl:ENST00000455705(transcript)|go:"GO:0000244"(spliceosomal tri-snRNP complex assembly)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000932"(P-body)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005688"(U6 snRNP)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006402"(mRNA catabolic process)|go:"GO:0017070"(U6 snRNA binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071011"(precatalytic spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0120115"(Lsm2-8 complex)|go:"GO:1990726"(Lsm1-7-Pat1 complex)|interpro:IPR001163(Like-Sm ribonucleoprotein, core)|interpro:IPR010920(Like-Sm ribonucleoprotein-related, core)|interpro:IPR016654(U6 snRNA-associated Sm-like protein LSm2)|mint:Q9Y333|rcsb pdb:3JCR|rcsb pdb:5O9Z|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6QW6|rcsb pdb:6QX9|rcsb pdb:7ABG|reactome:R-HSA-430039|reactome:R-HSA-72163|reactome:R-HSA-72165|ensembl:ENSG00000172850(gene)|ensembl:ENSG00000204392(gene)|ensembl:ENSG00000224979(gene)|ensembl:ENSG00000225998(gene)|ensembl:ENSG00000231502(gene)|ensembl:ENSG00000236826(gene)|dip:DIP-31139N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/09/18 rogid:uVbfLYa5ruPa6HBQehcQfXqI22w9606 rogid:lReyYTJxC/WlYg/ekKaqZiNNdVM9606 intact-crc:459DCCDBCE9031A4|rigid:xZ+7gpArwPK/H0YI4PMvpKSNG9Q false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q13107 uniprotkb:Q9UK45 intact:EBI-723290|uniprotkb:O43452|uniprotkb:O43453|uniprotkb:Q08AK8|ensembl:ENSP00000265560|uniprotkb:A8K6Y0|uniprotkb:C9IY91 intact:EBI-348372|ensembl:ENSP00000252622 psi-mi:ubp4_human(display_long)|uniprotkb:Ubiquitin-specific-processing protease 4(gene name synonym)|uniprotkb:Deubiquitinating enzyme 4(gene name synonym)|uniprotkb:Ubiquitous nuclear protein homolog(gene name synonym)|uniprotkb:USP4(gene name)|psi-mi:USP4(display_short)|uniprotkb:UNP(gene name synonym)|uniprotkb:UNPH(gene name synonym)|uniprotkb:Ubiquitin thioesterase 4(gene name synonym) psi-mi:lsm7_human(display_long)|uniprotkb:LSM7(gene name)|psi-mi:LSM7(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512900|imex:IM-12079-77 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003354.2|refseq:NP_955475.1|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031685"(adenosine receptor binding)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR018200|interpro:IPR028135|interpro:IPR028889|interpro:IPR035927|interpro:IPR038765|mint:Q13107|rcsb pdb:2Y6E|rcsb pdb:5CTR|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5689880|ensembl:ENSG00000114316(gene)|ensembl:ENST00000265560(transcript)|go:"GO:0000244"(spliceosomal tri-snRNP complex assembly)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0031397"(negative regulation of protein ubiquitination)|refseq:NP_001238806.1 refseq:NP_057283.1|interpro:IPR017132(U6 snRNA-associated Sm-like protein LSm7)|interpro:IPR044641|rcsb pdb:3JCR|rcsb pdb:5O9Z|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6QW6|rcsb pdb:6QX9|rcsb pdb:7ABG|reactome:R-HSA-430039|reactome:R-HSA-72163|go:"GO:0005689"(U12-type spliceosomal complex)|go:"GO:0005829"(cytosol)|go:"GO:0017070"(U6 snRNA binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0071004"(U2-type prespliceosome)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0097526"(spliceosomal tri-snRNP complex)|go:"GO:0120115"(Lsm2-8 complex)|go:"GO:1990726"(Lsm1-7-Pat1 complex)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR001163(Like-Sm ribonucleoprotein, core)|interpro:IPR010920(Like-Sm ribonucleoprotein-related, core)|ensembl:ENSG00000130332(gene)|ensembl:ENST00000252622(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000956"(nuclear-transcribed mRNA catabolic process)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005688"(U6 snRNP)|dip:DIP-31129N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/09/18 rogid:uVbfLYa5ruPa6HBQehcQfXqI22w9606 rogid:vT1gI3yzYl37cX++CUGdJowAL909606 intact-crc:459DCCDBCE9031A4|rigid:xZ+7gpArwPK/H0YI4PMvpKSNG9Q false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q13107 uniprotkb:Q9P0M2 intact:EBI-723290|uniprotkb:O43452|uniprotkb:O43453|uniprotkb:Q08AK8|ensembl:ENSP00000265560|uniprotkb:A8K6Y0|uniprotkb:C9IY91 intact:EBI-2512902|ensembl:ENSP00000405252|uniprotkb:Q9HCZ8|uniprotkb:B4DUC3 psi-mi:ubp4_human(display_long)|uniprotkb:Ubiquitin-specific-processing protease 4(gene name synonym)|uniprotkb:Deubiquitinating enzyme 4(gene name synonym)|uniprotkb:Ubiquitous nuclear protein homolog(gene name synonym)|uniprotkb:USP4(gene name)|psi-mi:USP4(display_short)|uniprotkb:UNP(gene name synonym)|uniprotkb:UNPH(gene name synonym)|uniprotkb:Ubiquitin thioesterase 4(gene name synonym) psi-mi:aka7g_human(display_long)|uniprotkb:AKAP7(gene name)|psi-mi:AKAP7(display_short)|uniprotkb:AKAP18(gene name synonym)|uniprotkb:Protein kinase A-anchoring protein 7 isoform gamma(gene name synonym)|uniprotkb:A-kinase anchor protein 18 kDa(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512900|imex:IM-12079-77 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003354.2|refseq:NP_955475.1|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031685"(adenosine receptor binding)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR018200|interpro:IPR028135|interpro:IPR028889|interpro:IPR035927|interpro:IPR038765|mint:Q13107|rcsb pdb:2Y6E|rcsb pdb:5CTR|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5689880|ensembl:ENSG00000114316(gene)|ensembl:ENST00000265560(transcript)|go:"GO:0000244"(spliceosomal tri-snRNP complex assembly)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0031397"(negative regulation of protein ubiquitination)|refseq:NP_001238806.1 ensembl:ENSG00000118507(gene)|ensembl:ENST00000431975(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|interpro:IPR009097(RNA ligase/cyclic nucleotide phosphodiesterase)|interpro:IPR019510|interpro:IPR019511|rcsb pdb:4ZP3|rcsb pdb:5JJ2|refseq:NP_057461.2 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/09/18 rogid:uVbfLYa5ruPa6HBQehcQfXqI22w9606 rogid:BCt7xqbd+kGycJeocp3Q/m+mbV89606 intact-crc:459DCCDBCE9031A4|rigid:xZ+7gpArwPK/H0YI4PMvpKSNG9Q false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q13107 uniprotkb:Q8WWY3 intact:EBI-723290|uniprotkb:O43452|uniprotkb:O43453|uniprotkb:Q08AK8|ensembl:ENSP00000265560|uniprotkb:A8K6Y0|uniprotkb:C9IY91 intact:EBI-1567797|uniprotkb:Q8N7F9|uniprotkb:Q9H271|uniprotkb:Q9Y439|uniprotkb:Q17RB4|intact:EBI-10177194|uniprotkb:F1T0A5|uniprotkb:E7ESA8|uniprotkb:F1T0A4|ensembl:ENSP00000324122|ensembl:ENSP00000483929 psi-mi:ubp4_human(display_long)|uniprotkb:Ubiquitin-specific-processing protease 4(gene name synonym)|uniprotkb:Deubiquitinating enzyme 4(gene name synonym)|uniprotkb:Ubiquitous nuclear protein homolog(gene name synonym)|uniprotkb:USP4(gene name)|psi-mi:USP4(display_short)|uniprotkb:UNP(gene name synonym)|uniprotkb:UNPH(gene name synonym)|uniprotkb:Ubiquitin thioesterase 4(gene name synonym) psi-mi:prp31_human(display_long)|uniprotkb:Pre-mRNA-processing factor 31(gene name synonym)|uniprotkb:U4/U6 snRNP 61 kDa protein(gene name synonym)|uniprotkb:Serologically defined breast cancer antigen NY-BR-99(gene name synonym)|uniprotkb:PRPF31(gene name)|psi-mi:PRPF31(display_short)|uniprotkb:PRP31(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512900|imex:IM-12079-77 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003354.2|refseq:NP_955475.1|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031685"(adenosine receptor binding)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR018200|interpro:IPR028135|interpro:IPR028889|interpro:IPR035927|interpro:IPR038765|mint:Q13107|rcsb pdb:2Y6E|rcsb pdb:5CTR|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5689880|ensembl:ENSG00000114316(gene)|ensembl:ENST00000265560(transcript)|go:"GO:0000244"(spliceosomal tri-snRNP complex assembly)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0031397"(negative regulation of protein ubiquitination)|refseq:NP_001238806.1 refseq:XP_006723200.1|refseq:NP_056444.3|ensembl:ENSG00000105618(gene)|ensembl:ENSG00000275885(gene)|ensembl:ENST00000321030(transcript)|ensembl:ENST00000613693(transcript)|go:"GO:0000244"(spliceosomal tri-snRNP complex assembly)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005684"(U2-type spliceosomal complex)|go:"GO:0071339"(MLL1 complex)|go:"GO:0097526"(spliceosomal tri-snRNP complex)|go:"GO:0005687"(U4 snRNP)|go:"GO:0005690"(U4atac snRNP)|go:"GO:0015030"(Cajal body)|go:"GO:0016607"(nuclear speck)|interpro:IPR002687(Pre-mRNA processing ribonucleoprotein, binding region)|go:"GO:0030621"(U4 snRNA binding)|go:"GO:0030622"(U4atac snRNA binding)|go:"GO:0042802"(identical protein binding)|interpro:IPR012976(NOSIC)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0070990"(snRNP binding)|interpro:IPR019175|interpro:IPR027105|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071011"(precatalytic spliceosome)|go:"GO:0071166"(ribonucleoprotein complex localization)|interpro:IPR036070|interpro:IPR042239|mint:Q8WWY3|rcsb pdb:2OZB|rcsb pdb:3JCR|rcsb pdb:3SIU|rcsb pdb:3SIV|rcsb pdb:5O9Z|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6QW6|rcsb pdb:6QX9|reactome:R-HSA-72163 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/09/18 rogid:uVbfLYa5ruPa6HBQehcQfXqI22w9606 rogid:NsXY3tY7Y2EEK8rxoisqlfpzuf89606 intact-crc:459DCCDBCE9031A4|rigid:xZ+7gpArwPK/H0YI4PMvpKSNG9Q false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q13107 uniprotkb:O43447 intact:EBI-723290|uniprotkb:O43452|uniprotkb:O43453|uniprotkb:Q08AK8|ensembl:ENSP00000265560|uniprotkb:A8K6Y0|uniprotkb:C9IY91 intact:EBI-1055615|intact:EBI-6190037|uniprotkb:A6NNE7|ensembl:ENSP00000503384|ensembl:ENSP00000503489|ensembl:ENSP00000503922|ensembl:ENSP00000504108|ensembl:ENSP00000504595|ensembl:ENSP00000361630|ensembl:ENSP00000306614 psi-mi:ubp4_human(display_long)|uniprotkb:Ubiquitin-specific-processing protease 4(gene name synonym)|uniprotkb:Deubiquitinating enzyme 4(gene name synonym)|uniprotkb:Ubiquitous nuclear protein homolog(gene name synonym)|uniprotkb:USP4(gene name)|psi-mi:USP4(display_short)|uniprotkb:UNP(gene name synonym)|uniprotkb:UNPH(gene name synonym)|uniprotkb:Ubiquitin thioesterase 4(gene name synonym) psi-mi:ppih_human(display_long)|uniprotkb:U-snRNP-associated cyclophilin SnuCyp-20(gene name synonym)|uniprotkb:Small nuclear ribonucleoprotein particle-specific cyclophilin H(gene name synonym)|uniprotkb:PPIH(gene name)|psi-mi:PPIH(display_short)|uniprotkb:CYP20(gene name synonym)|uniprotkb:CYPH(gene name synonym)|uniprotkb:Rotamase H(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512900|imex:IM-12079-77 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003354.2|refseq:NP_955475.1|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031685"(adenosine receptor binding)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR018200|interpro:IPR028135|interpro:IPR028889|interpro:IPR035927|interpro:IPR038765|mint:Q13107|rcsb pdb:2Y6E|rcsb pdb:5CTR|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5689880|ensembl:ENSG00000114316(gene)|ensembl:ENST00000265560(transcript)|go:"GO:0000244"(spliceosomal tri-snRNP complex assembly)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0031397"(negative regulation of protein ubiquitination)|refseq:NP_001238806.1 refseq:NP_006338.1|refseq:XP_005270419.1|ensembl:ENST00000304979(transcript)|ensembl:ENST00000372550(transcript)|ensembl:ENST00000676675(transcript)|ensembl:ENST00000677900(transcript)|ensembl:ENST00000678038(transcript)|ensembl:ENST00000678333(transcript)|ensembl:ENST00000678803(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006457"(protein folding)|go:"GO:0016018"(cyclosporin A binding)|go:"GO:0016607"(nuclear speck)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071001"(U4/U6 snRNP)|interpro:IPR002130(Peptidyl-prolyl cis-trans isomerase, cyclophilin-type)|interpro:IPR020892|interpro:IPR024936|interpro:IPR029000|mint:O43447|rcsb pdb:1MZW|rcsb pdb:1QOI|rcsb pdb:5O9Z|rcsb pdb:6AHD|reactome:R-HSA-72163|ensembl:ENSG00000171960(gene)|refseq:NP_001317439.1|refseq:XP_016855546.1|refseq:XP_016855547.1|refseq:XP_016855548.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/09/18 rogid:uVbfLYa5ruPa6HBQehcQfXqI22w9606 rogid:6gE98w/LLmT7FlCBnaBDk+GWvQU9606 intact-crc:459DCCDBCE9031A4|rigid:xZ+7gpArwPK/H0YI4PMvpKSNG9Q false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q13107 uniprotkb:O43395 intact:EBI-723290|uniprotkb:O43452|uniprotkb:O43453|uniprotkb:Q08AK8|ensembl:ENSP00000265560|uniprotkb:A8K6Y0|uniprotkb:C9IY91 intact:EBI-744322|uniprotkb:O43446|uniprotkb:Q5VT54|uniprotkb:B4DSY9|intact:EBI-28983618|ensembl:ENSP00000315379 psi-mi:ubp4_human(display_long)|uniprotkb:Ubiquitin-specific-processing protease 4(gene name synonym)|uniprotkb:Deubiquitinating enzyme 4(gene name synonym)|uniprotkb:Ubiquitous nuclear protein homolog(gene name synonym)|uniprotkb:USP4(gene name)|psi-mi:USP4(display_short)|uniprotkb:UNP(gene name synonym)|uniprotkb:UNPH(gene name synonym)|uniprotkb:Ubiquitin thioesterase 4(gene name synonym) psi-mi:prpf3_human(display_long)|uniprotkb:Pre-mRNA-splicing factor 3(gene name synonym)|uniprotkb:U4/U6 snRNP 90 kDa protein(gene name synonym)|uniprotkb:PRPF3(gene name)|psi-mi:PRPF3(display_short)|uniprotkb:HPRP3(gene name synonym)|uniprotkb:PRP3(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512900|imex:IM-12079-77 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003354.2|refseq:NP_955475.1|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031685"(adenosine receptor binding)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR018200|interpro:IPR028135|interpro:IPR028889|interpro:IPR035927|interpro:IPR038765|mint:Q13107|rcsb pdb:2Y6E|rcsb pdb:5CTR|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5689880|ensembl:ENSG00000114316(gene)|ensembl:ENST00000265560(transcript)|go:"GO:0000244"(spliceosomal tri-snRNP complex assembly)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0031397"(negative regulation of protein ubiquitination)|refseq:NP_001238806.1 refseq:NP_004689.1|ensembl:ENSP00000315379|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005829"(cytosol)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0015030"(Cajal body)|go:"GO:0016607"(nuclear speck)|go:"GO:0042802"(identical protein binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0071005"(U2-type precatalytic spliceosome)|interpro:IPR002483(Splicing factor PWI)|interpro:IPR010541(Protein of unknown function DUF1115)|interpro:IPR013881(Pre-mRNA-splicing factor 3)|interpro:IPR027104|interpro:IPR036483|mint:O43395|rcsb pdb:1X4Q|rcsb pdb:3JCR|rcsb pdb:5O9Z|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6QW6|rcsb pdb:6QX9|reactome:R-HSA-72163|ensembl:ENSG00000117360(gene)|ensembl:ENST00000324862(transcript)|go:"GO:0000244"(spliceosomal tri-snRNP complex assembly)|go:"GO:0000375"(RNA splicing, via transesterification reactions)|dip:DIP-34508N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/09/18 rogid:uVbfLYa5ruPa6HBQehcQfXqI22w9606 rogid:Y2aO1gQjTU8JERVtrLpgbXq7nLU9606 intact-crc:459DCCDBCE9031A4|rigid:xZ+7gpArwPK/H0YI4PMvpKSNG9Q false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q70EL3 uniprotkb:Q7Z6Z7 intact:EBI-2512953|uniprotkb:E9PP86 intact:EBI-625934|uniprotkb:O15029|uniprotkb:Q4G2Z2|uniprotkb:Q5H961|uniprotkb:Q6P4D0|uniprotkb:Q8NG67|uniprotkb:Q9BUI0|uniprotkb:Q9HCJ4|uniprotkb:Q9NSL6|uniprotkb:Q9P0A9|ensembl:ENSP00000262854|ensembl:ENSP00000340648 psi-mi:ubp50_human(display_long)|uniprotkb:USP50(gene name)|psi-mi:USP50(display_short)|uniprotkb:Inactive ubiquitin-specific peptidase 50(gene name synonym) psi-mi:huwe1_human(display_long)|uniprotkb:HECT, UBA and WWE domain-containing protein 1(gene name synonym)|uniprotkb:Upstream regulatory element-binding protein 1(gene name synonym)|uniprotkb:Mcl-1 ubiquitin ligase E3(gene name synonym)|uniprotkb:ARF-binding protein 1(gene name synonym)|uniprotkb:Large structure of UREB1(gene name synonym)|uniprotkb:Homologous to E6AP carboxyl terminus homologous protein 9(gene name synonym)|uniprotkb:HUWE1(gene name)|psi-mi:HUWE1(display_short)|uniprotkb:KIAA0312(gene name synonym)|uniprotkb:KIAA1578(gene name synonym)|uniprotkb:HSPC272(orf name)|uniprotkb:HECT-type E3 ubiquitin transferase HUWE1(gene name synonym)|uniprotkb:UREB1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512984|imex:IM-12079-27 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007032"(endosome organization)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019783"(ubiquitin-like protein-specific protease activity)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0030496"(midbody)|go:"GO:0031313"(extrinsic component of endosome membrane)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0035063"(nuclear speck organization)|go:"GO:0043197"(dendritic spine)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR028889|interpro:IPR038765|interpro:IPR018200|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|refseq:NP_987090.2 ensembl:ENSG00000086758(gene)|ensembl:ENST00000262854(transcript)|ensembl:ENST00000342160(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006284"(base-excision repair)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0007030"(Golgi organization)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0030154"(cell differentiation)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000569(HECT)|interpro:IPR004170(WWE)|interpro:IPR009060(UBA-like)|interpro:IPR010309(E3 ubiquitin ligase, region of unknown function DUF908)|interpro:IPR010314(E3 ubiquitin ligase, region of unknown function DUF913)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR025527|interpro:IPR035983|interpro:IPR037197|interpro:IPR041918|mint:Q7Z6Z7|rcsb pdb:2EKK|rcsb pdb:2MUL|rcsb pdb:3G1N|go:"GO:0061025"(membrane fusion)|rcsb pdb:5C6H|rcsb pdb:5LP8|rcsb pdb:6FYH|rcsb pdb:6MIW|rcsb pdb:6PFL|reactome:R-HSA-6798695|rcsb pdb:3H1D|reactome:R-HSA-983168|refseq:NP_113584.3|refseq:XP_005262022.1|dip:DIP-34362N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:0mYWm1LB6saDbgMfLqu3bJd8zdI9606 rogid:TnIn0mcFc81bJlMkyWTtq3n/uOg9606 intact-crc:432F21EBEAA88CCE|rigid:3W2zuTOU8mc+XHm3qFJmc0T5Kw4 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q70EL3 uniprotkb:Q9NQ29 intact:EBI-2512953|uniprotkb:E9PP86 intact:EBI-473747|uniprotkb:Q96S32|uniprotkb:Q9NPH4|uniprotkb:B8ZZ13|ensembl:ENSP00000293872 psi-mi:ubp50_human(display_long)|uniprotkb:USP50(gene name)|psi-mi:USP50(display_short)|uniprotkb:Inactive ubiquitin-specific peptidase 50(gene name synonym) psi-mi:luc7l_human(display_long)|uniprotkb:SR+89(gene name synonym)|uniprotkb:Putative SR protein LUC7B1(gene name synonym)|uniprotkb:LUC7L(gene name)|psi-mi:LUC7L(display_short)|uniprotkb:LUC7L1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512984|imex:IM-12079-27 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007032"(endosome organization)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019783"(ubiquitin-like protein-specific protease activity)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0030496"(midbody)|go:"GO:0031313"(extrinsic component of endosome membrane)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0035063"(nuclear speck organization)|go:"GO:0043197"(dendritic spine)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR028889|interpro:IPR038765|interpro:IPR018200|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|refseq:NP_987090.2 refseq:NP_001307155.1|refseq:NP_001317349.1|refseq:NP_060502.1|refseq:NP_958815.1|ensembl:ENSG00000007392(gene)|ensembl:ENST00000293872(transcript)|go:"GO:0003729"(mRNA binding)|go:"GO:0005685"(U1 snRNP)|go:"GO:0006376"(mRNA splice site selection)|go:"GO:0042802"(identical protein binding)|go:"GO:0071004"(U2-type prespliceosome)|interpro:IPR004882(LUC7 related)|mint:Q9NQ29 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:0mYWm1LB6saDbgMfLqu3bJd8zdI9606 rogid:Hsl0VZTCTP6UrKlo/FHOVwZqCaw9606 intact-crc:432F21EBEAA88CCE|rigid:3W2zuTOU8mc+XHm3qFJmc0T5Kw4 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q70EL3 uniprotkb:P11310 intact:EBI-2512953|uniprotkb:E9PP86 intact:EBI-514381|uniprotkb:Q9NYF1|uniprotkb:Q5T4U4|ensembl:ENSP00000359878 psi-mi:ubp50_human(display_long)|uniprotkb:USP50(gene name)|psi-mi:USP50(display_short)|uniprotkb:Inactive ubiquitin-specific peptidase 50(gene name synonym) psi-mi:acadm_human(display_long)|uniprotkb:Medium chain acyl-CoA dehydrogenase(gene name synonym)|uniprotkb:ACADM(gene name)|psi-mi:ACADM(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512984|imex:IM-12079-27 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007032"(endosome organization)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019783"(ubiquitin-like protein-specific protease activity)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0030496"(midbody)|go:"GO:0031313"(extrinsic component of endosome membrane)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0035063"(nuclear speck organization)|go:"GO:0043197"(dendritic spine)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR028889|interpro:IPR038765|interpro:IPR018200|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|refseq:NP_987090.2 refseq:NP_000007.1|refseq:NP_001120800.1|dip:DIP-34281N|ensembl:ENSG00000117054(gene)|ensembl:ENST00000370841(transcript)|go:"GO:0001889"(liver development)|go:"GO:0003995"(acyl-CoA dehydrogenase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005978"(glycogen biosynthetic process)|go:"GO:0006111"(regulation of gluconeogenesis)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0009409"(response to cold)|go:"GO:0009791"(post-embryonic development)|go:"GO:0019254"(carnitine metabolic process, CoA-linked)|go:"GO:0030424"(axon)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0033539"(fatty acid beta-oxidation using acyl-CoA dehydrogenase)|go:"GO:0042594"(response to starvation)|go:"GO:0042802"(identical protein binding)|go:"GO:0045329"(carnitine biosynthetic process)|go:"GO:0050660"(flavin adenine dinucleotide binding)|go:"GO:0051791"(medium-chain fatty acid metabolic process)|go:"GO:0051793"(medium-chain fatty acid catabolic process)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0070991"(medium-chain-acyl-CoA dehydrogenase activity)|interpro:IPR006089(Acyl-CoA dehydrogenase, conserved site)|interpro:IPR006091(Acyl-CoA dehydrogenase/oxidase, central region)|interpro:IPR009075(Acyl-CoA dehydrogenase/oxidase C-terminal)|interpro:IPR009100(Acyl-CoA dehydrogenase/oxidase, middle and N-terminal)|interpro:IPR013786(Acyl-CoA dehydrogenase/oxidase, N-terminal)|interpro:IPR034180|interpro:IPR036250|interpro:IPR037069|mint:P11310|rcsb pdb:1EGC|rcsb pdb:1EGD|rcsb pdb:1EGE|rcsb pdb:1T9G|rcsb pdb:2A1T|rcsb pdb:4P13|reactome:R-HSA-1989781|reactome:R-HSA-77288|reactome:R-HSA-77346|reactome:R-HSA-77348 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:0mYWm1LB6saDbgMfLqu3bJd8zdI9606 rogid:rfmTmYKNQr6R6ikvfYovZIctoz49606 intact-crc:432F21EBEAA88CCE|rigid:3W2zuTOU8mc+XHm3qFJmc0T5Kw4 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q70EL3 uniprotkb:Q9UJS0 intact:EBI-2512953|uniprotkb:E9PP86 intact:EBI-1222503|uniprotkb:O14566|uniprotkb:O14575|uniprotkb:Q9NZW1|uniprotkb:Q9UNI7|uniprotkb:Q546F9|ensembl:ENSP00000265631 psi-mi:ubp50_human(display_long)|uniprotkb:USP50(gene name)|psi-mi:USP50(display_short)|uniprotkb:Inactive ubiquitin-specific peptidase 50(gene name synonym) psi-mi:cmc2_human(display_long)|uniprotkb:SLC25A13(gene name)|psi-mi:SLC25A13(display_short)|uniprotkb:ARALAR2(gene name synonym)|uniprotkb:Mitochondrial aspartate glutamate carrier 2(gene name synonym)|uniprotkb:Solute carrier family 25 member 13(gene name synonym)|uniprotkb:Citrin(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512984|imex:IM-12079-27 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007032"(endosome organization)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019783"(ubiquitin-like protein-specific protease activity)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0030496"(midbody)|go:"GO:0031313"(extrinsic component of endosome membrane)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0035063"(nuclear speck organization)|go:"GO:0043197"(dendritic spine)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR028889|interpro:IPR038765|interpro:IPR018200|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|refseq:NP_987090.2 refseq:NP_055066.1|refseq:NP_001153682.1|go:"GO:0005313"(L-glutamate transmembrane transporter activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0006839"(mitochondrial transport)|go:"GO:0009066"(aspartate family amino acid metabolic process)|go:"GO:0015172"(acidic amino acid transmembrane transporter activity)|go:"GO:0015183"(L-aspartate transmembrane transporter activity)|go:"GO:0015810"(aspartate transmembrane transport)|go:"GO:0015813"(L-glutamate transmembrane transport)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043490"(malate-aspartate shuttle)|go:"GO:0045333"(cellular respiration)|go:"GO:0051592"(response to calcium ion)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR002067(Mitochondrial carrier protein)|interpro:IPR011992(EF-Hand type)|interpro:IPR018108|interpro:IPR023395|interpro:IPR029658|mint:Q9UJS0|rcsb pdb:4P5W|reactome:R-HSA-1268020|reactome:R-HSA-70263|reactome:R-HSA-8963693|ensembl:ENSG00000004864(gene)|ensembl:ENST00000265631(transcript) psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:0mYWm1LB6saDbgMfLqu3bJd8zdI9606 rogid:YtrKzkRujsJ/hzl2bJaLgJAAswI9606 intact-crc:432F21EBEAA88CCE|rigid:3W2zuTOU8mc+XHm3qFJmc0T5Kw4 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q70EL3 uniprotkb:P35613 intact:EBI-2512953|uniprotkb:E9PP86 intact:EBI-750709|uniprotkb:Q7Z796|uniprotkb:Q8IZL7|intact:EBI-2553051|uniprotkb:A6NJW1|uniprotkb:D3YLG5|ensembl:ENSP00000333769 psi-mi:ubp50_human(display_long)|uniprotkb:USP50(gene name)|psi-mi:USP50(display_short)|uniprotkb:Inactive ubiquitin-specific peptidase 50(gene name synonym) psi-mi:basi_human(display_long)|uniprotkb:Leukocyte activation antigen M6(gene name synonym)|uniprotkb:Collagenase stimulatory factor(gene name synonym)|uniprotkb:Extracellular matrix metalloproteinase inducer(gene name synonym)|uniprotkb:5F7(gene name synonym)|uniprotkb:Tumor cell-derived collagenase stimulatory factor(gene name synonym)|uniprotkb:OK blood group antigen(gene name synonym)|uniprotkb:BSG(gene name)|psi-mi:BSG(display_short)|uniprotkb:UNQ6505/PRO21383(orf name)|uniprotkb:Hepatoma-associated antigen(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512984|imex:IM-12079-27 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007032"(endosome organization)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019783"(ubiquitin-like protein-specific protease activity)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0030496"(midbody)|go:"GO:0031313"(extrinsic component of endosome membrane)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0035063"(nuclear speck organization)|go:"GO:0043197"(dendritic spine)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR028889|interpro:IPR038765|interpro:IPR018200|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|refseq:NP_987090.2 refseq:NP_001719.2|refseq:NP_940991.1|refseq:NP_940993.1|refseq:NP_001309172.1|refseq:NP_940992.1|refseq:XP_016882662.1|dip:DIP-50310N|ensembl:ENSG00000172270(gene)|ensembl:ENST00000333511(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001525"(angiogenesis)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0002080"(acrosomal membrane)|go:"GO:0003407"(neural retina development)|go:"GO:0005537"(mannose binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005768"(endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0007566"(embryo implantation)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0030424"(axon)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042383"(sarcolemma)|go:"GO:0042470"(melanosome)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045121"(membrane raft)|go:"GO:0045296"(cadherin binding)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0046598"(positive regulation of viral entry into host cell)|go:"GO:0046689"(response to mercury ion)|go:"GO:0046697"(decidualization)|go:"GO:0051591"(response to cAMP)|go:"GO:0061154"(endothelial tube morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070593"(dendrite self-avoidance)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098632"(cell-cell adhesion mediator activity)|go:"GO:1904466"(positive regulation of matrix metallopeptidase secretion)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR043204|interpro:IPR044157|mint:P35613|rcsb pdb:3B5H|rcsb pdb:3I84|rcsb pdb:3I85|rcsb pdb:3QQN|rcsb pdb:4U0Q|rcsb pdb:5X0T|rcsb pdb:5XF0|rcsb pdb:6LYY|rcsb pdb:6LZ0|rcsb pdb:7CKO|rcsb pdb:7CKR|rcsb pdb:7DA5|reactome:R-HSA-1474228|reactome:R-HSA-210991|reactome:R-HSA-216083|reactome:R-HSA-433692|reactome:R-HSA-5619070|reactome:R-HSA-70268|rcsb pdb:3QR2 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:0mYWm1LB6saDbgMfLqu3bJd8zdI9606 rogid:jVbDR+TKBzTjXoxR4At6XQg59ZA9606 intact-crc:432F21EBEAA88CCE|rigid:3W2zuTOU8mc+XHm3qFJmc0T5Kw4 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q70EL3 uniprotkb:P11172 intact:EBI-2512953|uniprotkb:E9PP86 intact:EBI-723452|uniprotkb:O00758|uniprotkb:O00759|uniprotkb:O00760|uniprotkb:Q16862|uniprotkb:Q9H3Q2|uniprotkb:Q9UG49|ensembl:ENSP00000232607|uniprotkb:B5LY68|uniprotkb:B5LY72 psi-mi:ubp50_human(display_long)|uniprotkb:USP50(gene name)|psi-mi:USP50(display_short)|uniprotkb:Inactive ubiquitin-specific peptidase 50(gene name synonym) psi-mi:umps_human(display_long)|uniprotkb:UMPS(gene name)|psi-mi:UMPS(display_short)|uniprotkb:OK/SW-cl.21(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512984|imex:IM-12079-27 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007032"(endosome organization)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019783"(ubiquitin-like protein-specific protease activity)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0030496"(midbody)|go:"GO:0031313"(extrinsic component of endosome membrane)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0035063"(nuclear speck organization)|go:"GO:0043197"(dendritic spine)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR028889|interpro:IPR038765|interpro:IPR018200|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|refseq:NP_987090.2 refseq:NP_000364.1|interpro:IPR014732(Orotidine 5'-phosphate decarboxylase, subfamily 1, core)|interpro:IPR018089|interpro:IPR023031|interpro:IPR029057|mint:P11172|rcsb pdb:2EAW|rcsb pdb:2JGY|rcsb pdb:2P1F|rcsb pdb:2QCC|rcsb pdb:2QCD|rcsb pdb:2QCE|rcsb pdb:2QCF|rcsb pdb:2QCG|rcsb pdb:2QCH|rcsb pdb:2QCL|go:"GO:0006222"(UMP biosynthetic process)|rcsb pdb:2QCM|rcsb pdb:2QCN|rcsb pdb:2V30|rcsb pdb:2WNS|rcsb pdb:3BGG|rcsb pdb:3BGJ|rcsb pdb:3BK0|go:"GO:0007565"(female pregnancy)|rcsb pdb:3BVJ|rcsb pdb:3DBP|go:"GO:0007595"(lactation)|go:"GO:0009116"(nucleoside metabolic process)|go:"GO:0019856"(pyrimidine nucleobase biosynthetic process)|go:"GO:0035690"|go:"GO:0042802"(identical protein binding)|go:"GO:0044205"('de novo' UMP biosynthetic process)|interpro:IPR000836(Phosphoribosyltransferase)|interpro:IPR001754(Orotidine 5'-phosphate decarboxylase, core)|interpro:IPR004467(Orotate phosphoribosyl transferase)|interpro:IPR011060(Ribulose-phosphate binding barrel)|interpro:IPR013785(Aldolase-type TIM barrel)|rcsb pdb:3EWU|rcsb pdb:3EWW|rcsb pdb:3EWY|rcsb pdb:3EWZ|rcsb pdb:3EX1|rcsb pdb:3EWX|rcsb pdb:3EX2|rcsb pdb:3EX3|rcsb pdb:3EX4|rcsb pdb:3EX6|rcsb pdb:3G3D|rcsb pdb:3G3M|rcsb pdb:3L0K|rcsb pdb:3L0N|rcsb pdb:3MI2|rcsb pdb:3MO7|rcsb pdb:3MW7|rcsb pdb:4HIB|rcsb pdb:4HKP|reactome:R-HSA-500753|ensembl:ENSG00000114491(gene)|ensembl:ENST00000232607(transcript)|go:"GO:0004588"(orotate phosphoribosyltransferase activity)|go:"GO:0004590"(orotidine-5'-phosphate decarboxylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006207"('de novo' pyrimidine nucleobase biosynthetic process)|dip:DIP-29595N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:0mYWm1LB6saDbgMfLqu3bJd8zdI9606 rogid:8HKx6eTv3pMPMJQzUhhFjyGXGZI9606 intact-crc:432F21EBEAA88CCE|rigid:3W2zuTOU8mc+XHm3qFJmc0T5Kw4 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q70EL3 uniprotkb:P51648 intact:EBI-2512953|uniprotkb:E9PP86 intact:EBI-1391128|uniprotkb:Q93011|uniprotkb:Q96J37|uniprotkb:Q6I9T3|ensembl:ENSP00000176643|ensembl:ENSP00000461916|ensembl:ENSP00000463637|ensembl:ENSP00000500092 psi-mi:ubp50_human(display_long)|uniprotkb:USP50(gene name)|psi-mi:USP50(display_short)|uniprotkb:Inactive ubiquitin-specific peptidase 50(gene name synonym) psi-mi:al3a2_human(display_long)|uniprotkb:Aldehyde dehydrogenase 10(gene name synonym)|uniprotkb:Microsomal aldehyde dehydrogenase(gene name synonym)|uniprotkb:ALDH3A2(gene name)|psi-mi:ALDH3A2(display_short)|uniprotkb:ALDH10(gene name synonym)|uniprotkb:FALDH(gene name synonym)|uniprotkb:Fatty aldehyde dehydrogenase(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512984|imex:IM-12079-27 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007032"(endosome organization)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019783"(ubiquitin-like protein-specific protease activity)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0030496"(midbody)|go:"GO:0031313"(extrinsic component of endosome membrane)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0035063"(nuclear speck organization)|go:"GO:0043197"(dendritic spine)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR028889|interpro:IPR038765|interpro:IPR018200|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|refseq:NP_987090.2 refseq:NP_000373.1|refseq:NP_001026976.1|refseq:XP_011522034.1|refseq:XP_011522035.1|refseq:XP_016879845.1|refseq:XP_016879846.1|ensembl:ENST00000672357(transcript)|go:"GO:0004028"(3-chloroallyl aldehyde dehydrogenase activity)|go:"GO:0004029"("aldehyde dehydrogenase (NAD+) activity")|go:"GO:0005777"(peroxisome)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006081"(cellular aldehyde metabolic process)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006714"(sesquiterpenoid metabolic process)|go:"GO:0007417"(central nervous system development)|go:"GO:0007422"(peripheral nervous system development)|go:"GO:0008544"(epidermis development)|go:"GO:0016021"(integral component of membrane)|go:"GO:0033306"(phytol metabolic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043878"("glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity")|go:"GO:0046458"(hexadecanal metabolic process)|go:"GO:0046577"(long-chain-alcohol oxidase activity)|go:"GO:0050061"(long-chain-aldehyde dehydrogenase activity)|go:"GO:0052814"(medium-chain-aldehyde dehydrogenase activity)|interpro:IPR012394("Aldehyde dehydrogenase NAD(P)-dependent")|interpro:IPR015590(Aldehyde dehydrogenase)|interpro:IPR016160(Aldehyde dehydrogenase, conserved site)|interpro:IPR016161(Aldehyde/histidinol dehydrogenase)|interpro:IPR016162(Aldehyde dehydrogenase, N-terminal)|interpro:IPR016163(Aldehyde dehydrogenase, C-terminal)|interpro:IPR029510|mint:P51648|rcsb pdb:4QGK|reactome:R-HSA-1660661|reactome:R-HSA-389599|reactome:R-HSA-9603798|reactome:R-HSA-9609523|reactome:R-HSA-9696270|reactome:R-HSA-9696273|ensembl:ENSG00000072210(gene)|ensembl:ENST00000176643(transcript)|ensembl:ENST00000579855(transcript)|ensembl:ENST00000581518(transcript) psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:0mYWm1LB6saDbgMfLqu3bJd8zdI9606 rogid:ADi5/NMf5JsjzaonzFIbHZebIlQ9606 intact-crc:432F21EBEAA88CCE|rigid:3W2zuTOU8mc+XHm3qFJmc0T5Kw4 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q70EL3 uniprotkb:Q92621 intact:EBI-2512953|uniprotkb:E9PP86 intact:EBI-1045046|uniprotkb:Q86YC1|uniprotkb:A6H8X3|ensembl:ENSP00000285968 psi-mi:ubp50_human(display_long)|uniprotkb:USP50(gene name)|psi-mi:USP50(display_short)|uniprotkb:Inactive ubiquitin-specific peptidase 50(gene name synonym) psi-mi:nu205_human(display_long)|uniprotkb:Nucleoporin Nup205(gene name synonym)|uniprotkb:205 kDa nucleoporin(gene name synonym)|uniprotkb:NUP205(gene name)|psi-mi:NUP205(display_short)|uniprotkb:C7orf14(gene name synonym)|uniprotkb:KIAA0225(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512984|imex:IM-12079-27 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007032"(endosome organization)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019783"(ubiquitin-like protein-specific protease activity)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0030496"(midbody)|go:"GO:0031313"(extrinsic component of endosome membrane)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0035063"(nuclear speck organization)|go:"GO:0043197"(dendritic spine)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR028889|interpro:IPR038765|interpro:IPR018200|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|refseq:NP_987090.2 ensembl:ENSG00000155561(gene)|ensembl:ENST00000285968(transcript)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005643"(nuclear pore)|go:"GO:0005829"(cytosol)|go:"GO:0006913"(nucleocytoplasmic transport)|go:"GO:0006999"(nuclear pore organization)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0017056"(structural constituent of nuclear pore)|go:"GO:0031965"(nuclear membrane)|go:"GO:0034399"(nuclear periphery)|go:"GO:0044611"(nuclear pore inner ring)|go:"GO:0051028"(mRNA transport)|go:"GO:0051292"(nuclear pore complex assembly)|interpro:IPR021827|mint:Q92621|rcsb pdb:5IJN|rcsb pdb:5IJO|reactome:R-HSA-1169408|reactome:R-HSA-159227|reactome:R-HSA-159230|reactome:R-HSA-159231|reactome:R-HSA-159236|reactome:R-HSA-165054|reactome:R-HSA-168271|reactome:R-HSA-168276|reactome:R-HSA-168325|reactome:R-HSA-168333|reactome:R-HSA-170822|reactome:R-HSA-180746|reactome:R-HSA-180910|reactome:R-HSA-191859|reactome:R-HSA-3108214|reactome:R-HSA-3232142|reactome:R-HSA-3301854|reactome:R-HSA-3371453|reactome:R-HSA-4085377|reactome:R-HSA-4551638|reactome:R-HSA-4570464|reactome:R-HSA-4615885|reactome:R-HSA-5578749|reactome:R-HSA-5619107|reactome:R-HSA-6784531|reactome:R-HSA-9609690|reactome:R-HSA-9610379|reactome:R-HSA-9615933|refseq:NP_055950.1|refseq:NP_001316363.1|dip:DIP-44021N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:0mYWm1LB6saDbgMfLqu3bJd8zdI9606 rogid:5lulE2tOZ4V1UZPwkEvOo9reZWE9606 intact-crc:432F21EBEAA88CCE|rigid:3W2zuTOU8mc+XHm3qFJmc0T5Kw4 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q70EL3 uniprotkb:P61221 intact:EBI-2512953|uniprotkb:E9PP86 intact:EBI-2510446|ensembl:ENSP00000296577|uniprotkb:Q6NR76|uniprotkb:O88793|uniprotkb:Q13181|uniprotkb:Q99K66|uniprotkb:Q13864|uniprotkb:Q96AL0|uniprotkb:Q96B10 psi-mi:ubp50_human(display_long)|uniprotkb:USP50(gene name)|psi-mi:USP50(display_short)|uniprotkb:Inactive ubiquitin-specific peptidase 50(gene name synonym) psi-mi:abce1_human(display_long)|uniprotkb:ABCE1(gene name)|psi-mi:ABCE1(display_short)|uniprotkb:RLI(gene name synonym)|uniprotkb:RNASEL1(gene name synonym)|uniprotkb:RNASELI(gene name synonym)|uniprotkb:RNS4I(gene name synonym)|uniprotkb:RNase L inhibitor(gene name synonym)|uniprotkb:Ribonuclease 4 inhibitor(gene name synonym)|uniprotkb:2'-5'-oligoadenylate-binding protein(gene name synonym)|uniprotkb:HuHP68(gene name synonym)|uniprotkb:OK/SW-cl.40(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512984|imex:IM-12079-27 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007032"(endosome organization)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019783"(ubiquitin-like protein-specific protease activity)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0030496"(midbody)|go:"GO:0031313"(extrinsic component of endosome membrane)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0035063"(nuclear speck organization)|go:"GO:0043197"(dendritic spine)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR028889|interpro:IPR038765|interpro:IPR018200|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|refseq:NP_987090.2 ensembl:ENSG00000164163(gene)|ensembl:ENST00000296577(transcript)|go:"GO:0000054"(ribosomal subunit export from nucleus)|go:"GO:0005506"(iron ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006413"(translational initiation)|go:"GO:0006415"(translational termination)|go:"GO:0006417"(regulation of translation)|go:"GO:0016020"(membrane)|go:"GO:0042626"(ATPase-coupled transmembrane transporter activity)|go:"GO:0043024"(ribosomal small subunit binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0060698"(endoribonuclease inhibitor activity)|go:"GO:0060702"(negative regulation of endoribonuclease activity)|interpro:IPR003439(ABC transporter-like)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR007209(Possible metal-binding region in RNase L inhibitor, RLI)|interpro:IPR013283(ABC transporter, ABCE)|interpro:IPR017871|interpro:IPR017896|interpro:IPR017900|interpro:IPR027417|interpro:IPR034348|mint:P61221|rcsb pdb:6ZME|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-8983711|reactome:R-HSA-909733|refseq:NP_001035809.1|refseq:NP_002931.2 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:0mYWm1LB6saDbgMfLqu3bJd8zdI9606 rogid:+6ykpRtI4p94M3TuoTzFBvdCsC09606 intact-crc:432F21EBEAA88CCE|rigid:3W2zuTOU8mc+XHm3qFJmc0T5Kw4 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q70EL3 uniprotkb:Q6UB35 intact:EBI-2512953|uniprotkb:E9PP86 intact:EBI-1046835|intact:EBI-28986171|ensembl:ENSP00000356290|uniprotkb:Q2TBF3|uniprotkb:Q8WVW0|uniprotkb:Q96HG8|uniprotkb:Q9H789|uniprotkb:Q9UFU8 psi-mi:ubp50_human(display_long)|uniprotkb:USP50(gene name)|psi-mi:USP50(display_short)|uniprotkb:Inactive ubiquitin-specific peptidase 50(gene name synonym) psi-mi:c1tm_human(display_long)|uniprotkb:MTHFD1L(gene name)|psi-mi:MTHFD1L(display_short)|uniprotkb:FTHFSDC1(gene name synonym)|uniprotkb:Formyltetrahydrofolate synthetase(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512984|imex:IM-12079-27 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007032"(endosome organization)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019783"(ubiquitin-like protein-specific protease activity)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0030496"(midbody)|go:"GO:0031313"(extrinsic component of endosome membrane)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0035063"(nuclear speck organization)|go:"GO:0043197"(dendritic spine)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR028889|interpro:IPR038765|interpro:IPR018200|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|refseq:NP_987090.2 ensembl:ENSG00000120254(gene)|ensembl:ENST00000367321(transcript)|go:"GO:0001843"(neural tube closure)|go:"GO:0004329"(formate-tetrahydrofolate ligase activity)|go:"GO:0004488"("methylenetetrahydrofolate dehydrogenase (NADP+) activity")|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006760"(folic acid-containing compound metabolic process)|go:"GO:0009257"(10-formyltetrahydrofolate biosynthetic process)|go:"GO:0015942"(formate metabolic process)|go:"GO:0016020"(membrane)|go:"GO:0035999"(tetrahydrofolate interconversion)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0048702"(embryonic neurocranium morphogenesis)|go:"GO:0048703"(embryonic viscerocranium morphogenesis)|interpro:IPR000559(Formate-tetrahydrofolate ligase, FTHFS)|interpro:IPR000672(Tetrahydrofolate dehydrogenase/cyclohydrolase)|interpro:IPR020628|interpro:IPR020630|interpro:IPR020631|interpro:IPR027417|interpro:IPR036291|reactome:R-HSA-196757|refseq:NP_001229696.1|refseq:NP_001229697.1|refseq:NP_001229698.1|refseq:NP_056255.2|ensembl:ENST00000367307|ensembl:ENSP00000356276|ensembl:ENSP00000356290 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:0mYWm1LB6saDbgMfLqu3bJd8zdI9606 rogid:lJRND1kcMEF99+fT1b+X8hfuLHM9606 intact-crc:432F21EBEAA88CCE|rigid:3W2zuTOU8mc+XHm3qFJmc0T5Kw4 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q70EL3 uniprotkb:O00410 intact:EBI-2512953|uniprotkb:E9PP86 intact:EBI-356424|uniprotkb:O15257|intact:EBI-1105173|uniprotkb:B4DZA0|uniprotkb:Q5T578|uniprotkb:Q86XC7|ensembl:ENSP00000350219|ensembl:ENSP00000418393|ensembl:ENSP00000499125 psi-mi:ubp50_human(display_long)|uniprotkb:USP50(gene name)|psi-mi:USP50(display_short)|uniprotkb:Inactive ubiquitin-specific peptidase 50(gene name synonym) psi-mi:ipo5_human(display_long)|uniprotkb:IPO5(gene name)|psi-mi:IPO5(display_short)|uniprotkb:KPNB3(gene name synonym)|uniprotkb:RANBP5(gene name synonym)|uniprotkb:Importin subunit beta-3(gene name synonym)|uniprotkb:Karyopherin beta-3(gene name synonym)|uniprotkb:Ran-binding protein 5(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512984|imex:IM-12079-27 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007032"(endosome organization)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019783"(ubiquitin-like protein-specific protease activity)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0030496"(midbody)|go:"GO:0031313"(extrinsic component of endosome membrane)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0035063"(nuclear speck organization)|go:"GO:0043197"(dendritic spine)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR028889|interpro:IPR038765|interpro:IPR018200|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|refseq:NP_987090.2 refseq:NP_002262.3|refseq:XP_011519389.1|refseq:XP_011519390.1|refseq:XP_011519391.1|refseq:XP_011519392.1|ensembl:ENSG00000065150(gene)|ensembl:ENST00000357602(transcript)|ensembl:ENST00000490680(transcript)|ensembl:ENST00000651721(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005095"(GTPase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005643"(nuclear pore)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006607"(NLS-bearing protein import into nucleus)|go:"GO:0006610"(ribosomal protein import into nucleus)|go:"GO:0008139"(nuclear localization sequence binding)|refseq:XP_005254109.1|refseq:XP_005254110.1|go:"GO:0016020"(membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0061608"(nuclear import signal receptor activity)|go:"GO:0071230"(cellular response to amino acid stimulus)|interpro:IPR000357(HEAT)|interpro:IPR001494(Importin-beta, N-terminal)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR034085|interpro:IPR040122|interpro:IPR040928|interpro:IPR041389|interpro:IPR041653|mint:O00410|rcsb pdb:6XTE|rcsb pdb:6XU2|reactome:R-HSA-192905|refseq:XP_016876051.1|dip:DIP-41042N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:0mYWm1LB6saDbgMfLqu3bJd8zdI9606 rogid:jBYLvkqyYyWAu1TdCVyCMh9ZHKY9606 intact-crc:432F21EBEAA88CCE|rigid:3W2zuTOU8mc+XHm3qFJmc0T5Kw4 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q70EL3 uniprotkb:Q15758 intact:EBI-2512953|uniprotkb:E9PP86 intact:EBI-356576|uniprotkb:D0EYG6|uniprotkb:B4DR77|uniprotkb:B7ZB81|uniprotkb:E9PC01|uniprotkb:O95720|uniprotkb:Q96RL9|uniprotkb:Q9BWQ3|uniprotkb:Q9UNP2|uniprotkb:A8K9H5|uniprotkb:B4DWS4|ensembl:ENSP00000444408 psi-mi:ubp50_human(display_long)|uniprotkb:USP50(gene name)|psi-mi:USP50(display_short)|uniprotkb:Inactive ubiquitin-specific peptidase 50(gene name synonym) psi-mi:aaat_human(display_long)|uniprotkb:ASCT2(gene name synonym)|uniprotkb:M7V1(gene name synonym)|uniprotkb:RDR(gene name synonym)|uniprotkb:RDRC(gene name synonym)|uniprotkb:SLC1A5(gene name)|psi-mi:SLC1A5(display_short)|uniprotkb:Sodium-dependent neutral amino acid transporter type 2(gene name synonym)|uniprotkb:RD114/simian type D retrovirus receptor(gene name synonym)|uniprotkb:Baboon M7 virus receptor(gene name synonym)|uniprotkb:Solute carrier family 1 member 5(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512984|imex:IM-12079-27 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007032"(endosome organization)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019783"(ubiquitin-like protein-specific protease activity)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0030496"(midbody)|go:"GO:0031313"(extrinsic component of endosome membrane)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0035063"(nuclear speck organization)|go:"GO:0043197"(dendritic spine)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR028889|interpro:IPR038765|interpro:IPR018200|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|refseq:NP_987090.2 refseq:NP_001138617.1|refseq:NP_005619.1|refseq:NP_001138616.1|go:"GO:0046872"(metal ion binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070207"(protein homotrimerization)|go:"GO:0140009"(L-aspartate import across plasma membrane)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1903803"(L-glutamine import across plasma membrane)|interpro:IPR001991("Sodium:dicarboxylate symporter")|interpro:IPR018107|interpro:IPR036458|mint:Q15758|rcsb pdb:5LLM|rcsb pdb:5LLU|rcsb pdb:5LM4|rcsb pdb:5MJU|rcsb pdb:6GCT|rcsb pdb:6MP6|rcsb pdb:6MPB|rcsb pdb:6RVX|rcsb pdb:6RVY|reactome:R-HSA-352230|reactome:R-HSA-9013149|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013409|reactome:R-HSA-9013423|go:"GO:0042470"(melanosome)|ensembl:ENSG00000105281(gene)|ensembl:ENST00000542575(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006865"(amino acid transport)|go:"GO:0006868"(glutamine transport)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0010585"(glutamine secretion)|go:"GO:0015171"(amino acid transmembrane transporter activity)|go:"GO:0015175"(neutral amino acid transmembrane transporter activity)|go:"GO:0015183"(L-aspartate transmembrane transporter activity)|go:"GO:0015186"(L-glutamine transmembrane transporter activity)|go:"GO:0015194"(L-serine transmembrane transporter activity)|go:"GO:0015293"(symporter activity)|go:"GO:0015804"(neutral amino acid transport)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0038023"(signaling receptor activity) psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:0mYWm1LB6saDbgMfLqu3bJd8zdI9606 rogid:nkh427WmAX5SLFm24BvEpyoyAmw9606 intact-crc:432F21EBEAA88CCE|rigid:3W2zuTOU8mc+XHm3qFJmc0T5Kw4 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q70EL3 uniprotkb:Q9C0C7 intact:EBI-2512953|uniprotkb:E9PP86 intact:EBI-2512975|ensembl:ENSP00000415327|ensembl:ENSP00000508322|uniprotkb:Q86XD6|uniprotkb:A6XN33|uniprotkb:Q9NXE7|uniprotkb:Q9H8Z0|intact:EBI-2556181|uniprotkb:D3DQP8|uniprotkb:G3V193 psi-mi:ubp50_human(display_long)|uniprotkb:USP50(gene name)|psi-mi:USP50(display_short)|uniprotkb:Inactive ubiquitin-specific peptidase 50(gene name synonym) psi-mi:amra1_human(display_long)|uniprotkb:AMBRA1(gene name)|psi-mi:AMBRA1(display_short)|uniprotkb:DCAF3(gene name synonym)|uniprotkb:DDB1- and CUL4-associated factor 3(gene name synonym)|uniprotkb:KIAA1736(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512984|imex:IM-12079-27 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007032"(endosome organization)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019783"(ubiquitin-like protein-specific protease activity)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0030496"(midbody)|go:"GO:0031313"(extrinsic component of endosome membrane)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0035063"(nuclear speck organization)|go:"GO:0043197"(dendritic spine)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR028889|interpro:IPR038765|interpro:IPR018200|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|refseq:NP_987090.2 ensembl:ENSG00000110497(gene)|ensembl:ENST00000458649(transcript)|ensembl:ENST00000683756(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000423"(mitophagy)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005930"(axoneme)|go:"GO:0006914"(autophagy)|go:"GO:0007399"(nervous system development)|go:"GO:0030154"(cell differentiation)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051020"(GTPase binding)|go:"GO:0098780"(response to mitochondrial depolarisation)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|reactome:R-HSA-1632852|refseq:NP_001287660.1|refseq:NP_060219.2|refseq:NP_001254711.1|refseq:NP_001254712.1|refseq:XP_005253066.1|refseq:XP_005253068.1|refseq:XP_005253071.1|refseq:XP_006718322.1|dip:DIP-53597N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:0mYWm1LB6saDbgMfLqu3bJd8zdI9606 rogid:h4yD2iL711peDzI4kttngSdTLQk9606 intact-crc:432F21EBEAA88CCE|rigid:3W2zuTOU8mc+XHm3qFJmc0T5Kw4 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q70EL3 uniprotkb:Q71U36 intact:EBI-2512953|uniprotkb:E9PP86 intact:EBI-302552|uniprotkb:P04687|uniprotkb:P05209|uniprotkb:A8K0B8|uniprotkb:G3V1U9|intact:EBI-10989786|ensembl:ENSP00000301071|ensembl:ENSP00000439020 psi-mi:ubp50_human(display_long)|uniprotkb:USP50(gene name)|psi-mi:USP50(display_short)|uniprotkb:Inactive ubiquitin-specific peptidase 50(gene name synonym) psi-mi:tba1a_human(display_long)|uniprotkb:TUBA1A(gene name)|psi-mi:TUBA1A(display_short)|uniprotkb:Tubulin B-alpha-1(gene name synonym)|uniprotkb:Tubulin alpha-3 chain(gene name synonym)|uniprotkb:Alpha-tubulin 3(gene name synonym)|uniprotkb:TUBA3(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512984|imex:IM-12079-27 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007032"(endosome organization)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019783"(ubiquitin-like protein-specific protease activity)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0030496"(midbody)|go:"GO:0031313"(extrinsic component of endosome membrane)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0035063"(nuclear speck organization)|go:"GO:0043197"(dendritic spine)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR028889|interpro:IPR038765|interpro:IPR018200|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|refseq:NP_987090.2 refseq:NP_006000.2|refseq:NP_001257328.1|refseq:NP_001257329.1|dip:DIP-32773N|ensembl:ENSG00000167552(gene)|ensembl:ENST00000295766(transcript)|ensembl:ENST00000301071(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0007017"(microtubule-based process)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030705"(cytoskeleton-dependent intracellular transport)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0043209"(myelin sheath)|go:"GO:0045121"(membrane raft)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0051301"(cell division)|go:"GO:0055037"(recycling endosome)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000217(Tubulin)|interpro:IPR002452(Alpha tubulin)|interpro:IPR003008(Tubulin/FtsZ, GTPase)|interpro:IPR008280(Tubulin/FtsZ, C-terminal)|interpro:IPR017975|interpro:IPR018316|interpro:IPR023123|interpro:IPR036525|interpro:IPR037103|mint:Q71U36|rcsb pdb:5JCO|rcsb pdb:6J8F|rcsb pdb:6WSL|rcsb pdb:7C1M|reactome:R-HSA-1445148|reactome:R-HSA-9646399|reactome:R-HSA-9648025|reactome:R-HSA-9668328|reactome:R-HSA-983189|reactome:R-HSA-190840|reactome:R-HSA-190861|reactome:R-HSA-2132295|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-2565942|reactome:R-HSA-3371497|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-389977|reactome:R-HSA-437239|reactome:R-HSA-5610787|reactome:R-HSA-5617833|reactome:R-HSA-5620912|reactome:R-HSA-5620924|reactome:R-HSA-5626467|reactome:R-HSA-5663220|reactome:R-HSA-6807878|reactome:R-HSA-6811434|reactome:R-HSA-6811436|reactome:R-HSA-68877|reactome:R-HSA-8852276|reactome:R-HSA-8854518|reactome:R-HSA-8955332|reactome:R-HSA-9609690|reactome:R-HSA-9609736|reactome:R-HSA-9619483 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:0mYWm1LB6saDbgMfLqu3bJd8zdI9606 rogid:1CzEzrf5y8hrQRPKgWQS1Wm1aCY9606 intact-crc:432F21EBEAA88CCE|rigid:3W2zuTOU8mc+XHm3qFJmc0T5Kw4 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q70EL3 uniprotkb:Q9Y4W6 intact:EBI-2512953|uniprotkb:E9PP86 intact:EBI-358755|uniprotkb:Q6P1L0|ensembl:ENSP00000269143 psi-mi:ubp50_human(display_long)|uniprotkb:USP50(gene name)|psi-mi:USP50(display_short)|uniprotkb:Inactive ubiquitin-specific peptidase 50(gene name synonym) psi-mi:afg32_human(display_long)|uniprotkb:AFG3L2(gene name)|psi-mi:AFG3L2(display_short)|uniprotkb:Paraplegin-like protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512984|imex:IM-12079-27 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007032"(endosome organization)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019783"(ubiquitin-like protein-specific protease activity)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0030496"(midbody)|go:"GO:0031313"(extrinsic component of endosome membrane)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0035063"(nuclear speck organization)|go:"GO:0043197"(dendritic spine)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR028889|interpro:IPR038765|interpro:IPR018200|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|refseq:NP_987090.2 ensembl:ENSG00000141385(gene)|ensembl:ENST00000269143(transcript)|go:"GO:0004176"(ATP-dependent peptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005745"(m-AAA complex)|go:"GO:0006508"(proteolysis)|go:"GO:0007409"(axonogenesis)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008053"(mitochondrial fusion)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016485"(protein processing)|go:"GO:0016540"(protein autoprocessing)|refseq:NP_006787.2|go:"GO:0021675"(nerve development)|go:"GO:0033619"(membrane protein proteolysis)|go:"GO:0034982"(mitochondrial protein processing)|go:"GO:0036444"(calcium import into the mitochondrion)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042407"(cristae formation)|go:"GO:0042552"(myelination)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051560"(mitochondrial calcium ion homeostasis)|go:"GO:0055001"(muscle cell development)|go:"GO:0060013"(righting reflex)|go:"GO:0065003"(protein-containing complex assembly)|interpro:IPR000642(Peptidase M41)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR005936(Peptidase M41, FtsH)|interpro:IPR011546(Peptidase M41, FtsH extracellular)|interpro:IPR027417|interpro:IPR037219|interpro:IPR041569|mint:Q9Y4W6|rcsb pdb:2LNA|rcsb pdb:6NYY|reactome:R-HSA-8949664 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:0mYWm1LB6saDbgMfLqu3bJd8zdI9606 rogid:5S4ucntvmQpRTehJ0QBEAYsGN089606 intact-crc:432F21EBEAA88CCE|rigid:3W2zuTOU8mc+XHm3qFJmc0T5Kw4 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q70EL3 uniprotkb:P28288 intact:EBI-2512953|uniprotkb:E9PP86 intact:EBI-80992|ensembl:ENSP00000359233|uniprotkb:Q15271|uniprotkb:Q9H529|uniprotkb:Q6NUN5|uniprotkb:Q96DA3|uniprotkb:D3DT46 psi-mi:ubp50_human(display_long)|uniprotkb:USP50(gene name)|psi-mi:USP50(display_short)|uniprotkb:Inactive ubiquitin-specific peptidase 50(gene name synonym) psi-mi:abcd3_human(display_long)|uniprotkb:ABCD3(gene name)|psi-mi:ABCD3(display_short)|uniprotkb:PMP70(gene name synonym)|uniprotkb:PXMP1(gene name synonym)|uniprotkb:70 kDa peroxisomal membrane protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512984|imex:IM-12079-27 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007032"(endosome organization)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019783"(ubiquitin-like protein-specific protease activity)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0030496"(midbody)|go:"GO:0031313"(extrinsic component of endosome membrane)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0035063"(nuclear speck organization)|go:"GO:0043197"(dendritic spine)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR028889|interpro:IPR038765|interpro:IPR018200|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|refseq:NP_987090.2 ensembl:ENSG00000117528(gene)|ensembl:ENST00000370214(transcript)|go:"GO:0005324"(long-chain fatty acid transporter activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005777"(peroxisome)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0007031"(peroxisome organization)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0015910"(long-chain fatty acid import into peroxisome)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0042493"|go:"GO:0042626"(ATPase-coupled transmembrane transporter activity)|refseq:NP_001116146.1|refseq:NP_002849.1|go:"GO:0042760"(very long-chain fatty acid catabolic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043621"(protein self-association)|interpro:IPR003439(ABC transporter-like)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR005283(Peroxysomal long chain fatty acyl transporter)|interpro:IPR011527(ABC transporter, transmembrane region, type 1)|interpro:IPR017871|interpro:IPR027417|interpro:IPR036640|mint:P28288|reactome:R-HSA-1369062|reactome:R-HSA-8980692|reactome:R-HSA-9013106|reactome:R-HSA-9603798 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:0mYWm1LB6saDbgMfLqu3bJd8zdI9606 rogid:aUTR1BDihIx1JxtsC5V4vmFAwA49606 intact-crc:432F21EBEAA88CCE|rigid:3W2zuTOU8mc+XHm3qFJmc0T5Kw4 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q70EL3 uniprotkb:Q9Y5M8 intact:EBI-2512953|uniprotkb:E9PP86 intact:EBI-355393|uniprotkb:Q8N2D8|uniprotkb:Q6P595|ensembl:ENSP00000418401|ensembl:ENSP00000503923 psi-mi:ubp50_human(display_long)|uniprotkb:USP50(gene name)|psi-mi:USP50(display_short)|uniprotkb:Inactive ubiquitin-specific peptidase 50(gene name synonym) psi-mi:srprb_human(display_long)|uniprotkb:SRPRB(gene name)|psi-mi:SRPRB(display_short)|uniprotkb:PSEC0230(orf name)|uniprotkb:Protein APMCF1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512984|imex:IM-12079-27 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007032"(endosome organization)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019783"(ubiquitin-like protein-specific protease activity)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0030496"(midbody)|go:"GO:0031313"(extrinsic component of endosome membrane)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0035063"(nuclear speck organization)|go:"GO:0043197"(dendritic spine)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR028889|interpro:IPR038765|interpro:IPR018200|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|refseq:NP_987090.2 refseq:NP_067026.3|ensembl:ENSG00000144867(gene)|ensembl:ENST00000466490(transcript)|ensembl:ENST00000678299(transcript)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005785"(signal recognition particle receptor complex)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0045047"(protein targeting to ER)|interpro:IPR019009|interpro:IPR027417|mint:Q9Y5M8|rcsb pdb:7NFX|reactome:R-HSA-1799339|reactome:R-HSA-381038|dip:DIP-50218N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:0mYWm1LB6saDbgMfLqu3bJd8zdI9606 rogid:pHUdnCvOhMRYIJg//OJ+SlCard49606 intact-crc:432F21EBEAA88CCE|rigid:3W2zuTOU8mc+XHm3qFJmc0T5Kw4 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q70EL3 uniprotkb:P62879 intact:EBI-2512953|uniprotkb:E9PP86 intact:EBI-356942|uniprotkb:P54312|uniprotkb:P11016|uniprotkb:B3KPU1|ensembl:ENSP00000305260|ensembl:ENSP00000377501|ensembl:ENSP00000377503 psi-mi:ubp50_human(display_long)|uniprotkb:USP50(gene name)|psi-mi:USP50(display_short)|uniprotkb:Inactive ubiquitin-specific peptidase 50(gene name synonym) psi-mi:gbb2_human(display_long)|uniprotkb:GNB2(gene name)|psi-mi:GNB2(display_short)|uniprotkb:Transducin beta chain 2(gene name synonym)|uniprotkb:G protein subunit beta-2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512984|imex:IM-12079-27 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007032"(endosome organization)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019783"(ubiquitin-like protein-specific protease activity)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0030496"(midbody)|go:"GO:0031313"(extrinsic component of endosome membrane)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0035063"(nuclear speck organization)|go:"GO:0043197"(dendritic spine)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR028889|interpro:IPR038765|interpro:IPR018200|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|refseq:NP_987090.2 refseq:NP_005264.2|go:"GO:0031682"(G-protein gamma-subunit binding)|go:"GO:0031982"(vesicle)|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051020"(GTPase binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001632(G-protein, beta subunit)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016346(Guanine nucleotide-binding protein, beta subunit)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|mint:P62879|reactome:R-HSA-1296041|reactome:R-HSA-163359|reactome:R-HSA-202040|reactome:R-HSA-381676|reactome:R-HSA-392170|reactome:R-HSA-392451|reactome:R-HSA-392851|reactome:R-HSA-400042|reactome:R-HSA-4086398|reactome:R-HSA-416476|reactome:R-HSA-416482|reactome:R-HSA-418217|reactome:R-HSA-418555|reactome:R-HSA-418592|reactome:R-HSA-418594|reactome:R-HSA-418597|reactome:R-HSA-420092|reactome:R-HSA-428930|reactome:R-HSA-432040|reactome:R-HSA-456926|reactome:R-HSA-500657|reactome:R-HSA-6814122|reactome:R-HSA-8964315|reactome:R-HSA-8964616|reactome:R-HSA-9009391|reactome:R-HSA-9660821|reactome:R-HSA-997272|go:"GO:0016020"(membrane)|ensembl:ENSG00000172354(gene)|ensembl:ENST00000303210(transcript)|ensembl:ENST00000393924(transcript)|ensembl:ENST00000393926(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0005925"(focal adhesion)|go:"GO:0007186"(G protein-coupled receptor signaling pathway) psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:0mYWm1LB6saDbgMfLqu3bJd8zdI9606 rogid:dingPUxdpAhe7UMLquv0eqXNtUM9606 intact-crc:432F21EBEAA88CCE|rigid:3W2zuTOU8mc+XHm3qFJmc0T5Kw4 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q70EL3 uniprotkb:Q8NCM8 intact:EBI-2512953|uniprotkb:E9PP86 intact:EBI-2512957|ensembl:ENSP00000364887|uniprotkb:Q7Z363|uniprotkb:O00432|uniprotkb:Q9HAE4|uniprotkb:Q8N977|uniprotkb:Q3C1U8|uniprotkb:Q6ZMX7|uniprotkb:Q16693|uniprotkb:Q6ZUM6|uniprotkb:Q4AC93|uniprotkb:Q92815|intact:EBI-2860086 psi-mi:ubp50_human(display_long)|uniprotkb:USP50(gene name)|psi-mi:USP50(display_short)|uniprotkb:Inactive ubiquitin-specific peptidase 50(gene name synonym) psi-mi:dyhc2_human(display_long)|uniprotkb:DYNC2H1(gene name)|psi-mi:DYNC2H1(display_short)|uniprotkb:DYH1B(gene name synonym)|uniprotkb:KIAA1997(gene name synonym)|uniprotkb:Cytoplasmic dynein 2 heavy chain(gene name synonym)|uniprotkb:Dynein cytoplasmic heavy chain 2(gene name synonym)|uniprotkb:Dynein heavy chain isotype 1B(gene name synonym)|uniprotkb:Dynein heavy chain 11(gene name synonym)|uniprotkb:DHC1B(gene name synonym)|uniprotkb:DHC2(gene name synonym)|uniprotkb:DNCH2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512984|imex:IM-12079-27 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007032"(endosome organization)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019783"(ubiquitin-like protein-specific protease activity)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0030496"(midbody)|go:"GO:0031313"(extrinsic component of endosome membrane)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0035063"(nuclear speck organization)|go:"GO:0043197"(dendritic spine)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR028889|interpro:IPR038765|interpro:IPR018200|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|refseq:NP_987090.2 interpro:IPR027417|interpro:IPR035699|interpro:IPR035706|interpro:IPR041228|interpro:IPR041658|interpro:IPR042219|interpro:IPR042222|interpro:IPR042228|interpro:IPR043157|interpro:IPR043160|rcsb pdb:4RH7|reactome:R-HSA-5610787|reactome:R-HSA-5620924|ensembl:ENSG00000187240(gene)|ensembl:ENST00000375735(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0003774"(cytoskeletal motor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0005930"(axoneme)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0007030"(Golgi organization)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0016485"(protein processing)|go:"GO:0021522"(spinal cord motor neuron differentiation)|go:"GO:0030286"(dynein complex)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0030900"(forebrain development)|go:"GO:0031514"(motile cilium)|go:"GO:0035721"(intraciliary retrograde transport)|go:"GO:0045177"(apical part of cell)|go:"GO:0045505"(dynein intermediate chain binding)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0051959"(dynein light intermediate chain binding)|go:"GO:0060271"(cilium assembly)|go:"GO:0060976"(coronary vasculature development)|go:"GO:0061512"(protein localization to cilium)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097542"(ciliary tip)|go:"GO:1905515"(non-motile cilium assembly)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR004273(Dynein heavy chain)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0008569"(minus-end-directed microtubule motor activity)|interpro:IPR013594(Dynein heavy chain, N-terminal region 1)|interpro:IPR013602(Dynein heavy chain, N-terminal region 2)|interpro:IPR024317|interpro:IPR024743|interpro:IPR026815|interpro:IPR026983|refseq:NP_001073932.1|refseq:NP_001368.2 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:0mYWm1LB6saDbgMfLqu3bJd8zdI9606 rogid:c6bU2mT13JkjPNR9maL9+/R3IIg9606 intact-crc:432F21EBEAA88CCE|rigid:3W2zuTOU8mc+XHm3qFJmc0T5Kw4 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q70EL3 uniprotkb:Q07065 intact:EBI-2512953|uniprotkb:E9PP86 intact:EBI-702400|uniprotkb:Q504S5|uniprotkb:Q53ES6|ensembl:ENSP00000367265 psi-mi:ubp50_human(display_long)|uniprotkb:USP50(gene name)|psi-mi:USP50(display_short)|uniprotkb:Inactive ubiquitin-specific peptidase 50(gene name synonym) psi-mi:ckap4_human(display_long)|uniprotkb:CKAP4(gene name)|psi-mi:CKAP4(display_short)|uniprotkb:63-kDa cytoskeleton-linking membrane protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512984|imex:IM-12079-27 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007032"(endosome organization)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019783"(ubiquitin-like protein-specific protease activity)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0030496"(midbody)|go:"GO:0031313"(extrinsic component of endosome membrane)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0035063"(nuclear speck organization)|go:"GO:0043197"(dendritic spine)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR028889|interpro:IPR038765|interpro:IPR018200|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|refseq:NP_987090.2 refseq:NP_006816.2|ensembl:ENSG00000136026(gene)|ensembl:ENST00000378026(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0035579"(specific granule membrane)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042599"(lamellar body)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070062"(extracellular exosome)|interpro:IPR028428|mint:Q07065|reactome:R-HSA-381426|reactome:R-HSA-5683826|reactome:R-HSA-6798695|reactome:R-HSA-8957275|reactome:R-HSA-9696264|reactome:R-HSA-9696270 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:0mYWm1LB6saDbgMfLqu3bJd8zdI9606 rogid:Q1hrxqh5k4Myf7J0To8Ecm/xxs49606 intact-crc:432F21EBEAA88CCE|rigid:3W2zuTOU8mc+XHm3qFJmc0T5Kw4 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q70EL3 uniprotkb:P11717 intact:EBI-2512953|uniprotkb:E9PP86 intact:EBI-1048580|uniprotkb:Q7Z7G9|uniprotkb:Q96PT5|ensembl:ENSP00000349437 psi-mi:ubp50_human(display_long)|uniprotkb:USP50(gene name)|psi-mi:USP50(display_short)|uniprotkb:Inactive ubiquitin-specific peptidase 50(gene name synonym) psi-mi:mpri_human(display_long)|uniprotkb:Insulin-like growth factor 2 receptor(gene name synonym)|uniprotkb:Insulin-like growth factor II receptor(gene name synonym)|uniprotkb:M6P/IGF2 receptor(gene name synonym)|uniprotkb:300 kDa mannose 6-phosphate receptor(gene name synonym)|uniprotkb:IGF2R(gene name)|psi-mi:IGF2R(display_short)|uniprotkb:MPRI(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2512984|imex:IM-12079-27 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007032"(endosome organization)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019783"(ubiquitin-like protein-specific protease activity)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0030496"(midbody)|go:"GO:0031313"(extrinsic component of endosome membrane)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032741"(positive regulation of interleukin-18 production)|go:"GO:0035063"(nuclear speck organization)|go:"GO:0043197"(dendritic spine)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|interpro:IPR028889|interpro:IPR038765|interpro:IPR018200|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|refseq:NP_987090.2 refseq:NP_000867.2|go:"GO:0001965"(G-protein alpha-subunit binding)|go:"GO:0001972"(retinoic acid binding)|go:"GO:0005010"(insulin-like growth factor-activated receptor activity)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005537"(mannose binding)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006898"(receptor-mediated endocytosis)|ensembl:ENSG00000197081(gene)|go:"GO:0007041"(lysosomal transport)|go:"GO:0007165"(signal transduction)|ensembl:ENST00000356956(transcript)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0001889"(liver development)|go:"GO:0007283"(spermatogenesis)|go:"GO:0009791"(post-embryonic development)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0030118"(clathrin coat)|go:"GO:0030133"(transport vesicle)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031995"(insulin-like growth factor II binding)|go:"GO:0032526"(response to retinoic acid)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0044794"(positive regulation by host of viral process)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904772"(response to tetrachloromethane)|go:"GO:1905394"(retromer complex binding)|interpro:IPR000479(Cation-independent mannose-6-phosphate receptor)|interpro:IPR000562(Type II fibronectin, collagen-binding)|interpro:IPR009011(Mannose-6-phosphate receptor, binding)|interpro:IPR013806(Kringle-like fold)|interpro:IPR036943|interpro:IPR044865|mint:P11717|rcsb pdb:1E6F|rcsb pdb:1GP0|rcsb pdb:1GP3|rcsb pdb:1GQB|rcsb pdb:1JPL|rcsb pdb:1JWG|rcsb pdb:1LF8|rcsb pdb:2CNJ|rcsb pdb:2L29|rcsb pdb:2L2A|rcsb pdb:2M68|rcsb pdb:2M6T|rcsb pdb:2V5N|rcsb pdb:2V5O|rcsb pdb:2V5P|rcsb pdb:5IEI|rcsb pdb:6N5X|rcsb pdb:6N5Y|rcsb pdb:6P8I|rcsb pdb:6V02|rcsb pdb:6Z30|rcsb pdb:6Z31|rcsb pdb:6Z32|reactome:R-HSA-432722|reactome:R-HSA-6798695|reactome:R-HSA-6811440|reactome:R-HSA-8856825|reactome:R-HSA-8856828|dip:DIP-6027N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:0mYWm1LB6saDbgMfLqu3bJd8zdI9606 rogid:7lkG6WR8MQ/SONiTV/8g1ZTtKTU9606 intact-crc:432F21EBEAA88CCE|rigid:3W2zuTOU8mc+XHm3qFJmc0T5Kw4 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q504Q3 uniprotkb:P48444 intact:EBI-1058976|uniprotkb:Q76E12|uniprotkb:O75189|uniprotkb:Q8IVE1|intact:EBI-2513034|ensembl:ENSP00000401721|ensembl:ENSP00000449861|ensembl:ENSP00000481859 intact:EBI-1044491|ensembl:ENSP00000264028|uniprotkb:Q52M80|uniprotkb:B4E1X2|uniprotkb:E9PEU4 psi-mi:pan2_human(display_long)|uniprotkb:PAN2(gene name)|psi-mi:PAN2(display_short)|uniprotkb:KIAA0710(gene name synonym)|uniprotkb:USP52(gene name synonym)|uniprotkb:Inactive ubiquitin carboxyl-terminal hydrolase 52(gene name synonym)|uniprotkb:"PAB1P-dependent poly(A)-specific ribonuclease"(gene name synonym)|uniprotkb:"Poly(A)-nuclease deadenylation complex subunit 2"(gene name synonym) psi-mi:copd_human(display_long)|uniprotkb:Delta-coat protein(gene name synonym)|uniprotkb:ARCN1(gene name)|psi-mi:ARCN1(display_short)|uniprotkb:COPD(gene name synonym)|uniprotkb:Archain(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513052|imex:IM-12079-79 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001120932.1|refseq:NP_001159751.1|refseq:NP_055686.3|ensembl:ENSG00000135473(gene)|ensembl:ENST00000425394(transcript)|ensembl:ENST00000548043(transcript)|ensembl:ENST00000610546(transcript)|go:"GO:0000175"(3'-5'-exoribonuclease activity)|go:"GO:0000289"("nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0000932"(P-body)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0004535"("poly(A)-specific ribonuclease activity")|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006397"(mRNA processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010606"(positive regulation of cytoplasmic mRNA processing body assembly)|go:"GO:0031251"(PAN complex)|go:"GO:0046872"(metal ion binding)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR013520(Exonuclease, RNase T and DNA polymerase III)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR028881|interpro:IPR028889|interpro:IPR030843|interpro:IPR036322|interpro:IPR036397|interpro:IPR038765|reactome:R-HSA-429947|dip:DIP-50708N ensembl:ENSG00000095139(gene)|ensembl:ENST00000264028(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003723"(RNA binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0016020"(membrane)|go:"GO:0021691"(cerebellar Purkinje cell layer maturation)|go:"GO:0030126"(COPI vesicle coat)|go:"GO:0030133"(transport vesicle)|go:"GO:0043473"(pigmentation)|go:"GO:0051645"(Golgi localization)|interpro:IPR011012(Longin-like)|interpro:IPR022775|interpro:IPR027059|interpro:IPR028565|interpro:IPR036168|mint:P48444|reactome:R-HSA-6807878|reactome:R-HSA-6811434|refseq:NP_001135753.1|refseq:NP_001646.2|dip:DIP-50375N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/04/15 rogid:2q3q4qXEhEU25TR01JaiCy1T8HE9606 rogid:67dTqyFC/zHDlTapW36OMyXbz0M9606 intact-crc:27224B9090B3D142|rigid:yjNxrwv8i5avaBpfN0XvlWC/AYE false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q504Q3 uniprotkb:Q15149 intact:EBI-1058976|uniprotkb:Q76E12|uniprotkb:O75189|uniprotkb:Q8IVE1|intact:EBI-2513034|ensembl:ENSP00000401721|ensembl:ENSP00000449861|ensembl:ENSP00000481859 intact:EBI-297903|intact:EBI-1103289|intact:EBI-1103265|intact:EBI-1055056|uniprotkb:Q15148|uniprotkb:Q16640|ensembl:ENSP00000323856|uniprotkb:Q6S376|intact:EBI-28976159|uniprotkb:Q6S380|intact:EBI-1103313|uniprotkb:Q6S377|uniprotkb:Q6S378|uniprotkb:Q6S379|intact:EBI-1103301|intact:EBI-1103253|uniprotkb:Q6S381|uniprotkb:Q6S382|uniprotkb:Q6S383|intact:EBI-2825763 psi-mi:pan2_human(display_long)|uniprotkb:PAN2(gene name)|psi-mi:PAN2(display_short)|uniprotkb:KIAA0710(gene name synonym)|uniprotkb:USP52(gene name synonym)|uniprotkb:Inactive ubiquitin carboxyl-terminal hydrolase 52(gene name synonym)|uniprotkb:"PAB1P-dependent poly(A)-specific ribonuclease"(gene name synonym)|uniprotkb:"Poly(A)-nuclease deadenylation complex subunit 2"(gene name synonym) psi-mi:plec_human(display_long)|uniprotkb:PLEC(gene name)|psi-mi:PLEC(display_short)|uniprotkb:Hemidesmosomal protein 1(gene name synonym)|uniprotkb:PLEC1(gene name synonym)|uniprotkb:Plectin-1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513052|imex:IM-12079-79 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001120932.1|refseq:NP_001159751.1|refseq:NP_055686.3|ensembl:ENSG00000135473(gene)|ensembl:ENST00000425394(transcript)|ensembl:ENST00000548043(transcript)|ensembl:ENST00000610546(transcript)|go:"GO:0000175"(3'-5'-exoribonuclease activity)|go:"GO:0000289"("nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0000932"(P-body)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0004535"("poly(A)-specific ribonuclease activity")|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006397"(mRNA processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010606"(positive regulation of cytoplasmic mRNA processing body assembly)|go:"GO:0031251"(PAN complex)|go:"GO:0046872"(metal ion binding)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR013520(Exonuclease, RNase T and DNA polymerase III)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR028881|interpro:IPR028889|interpro:IPR030843|interpro:IPR036322|interpro:IPR036397|interpro:IPR038765|reactome:R-HSA-429947|dip:DIP-50708N go:"GO:0030018"(Z disc)|go:"GO:0030056"(hemidesmosome)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031581"(hemidesmosome assembly)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0032094"(response to food)|go:"GO:0032287"(peripheral nervous system myelin maintenance)|go:"GO:0034332"(adherens junction organization)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0042060"(wound healing)|go:"GO:0042383"(sarcolemma)|go:"GO:0043034"(costamere)|go:"GO:0043114"(regulation of vascular permeability)|go:"GO:0043209"(myelin sheath)|go:"GO:0043621"(protein self-association)|go:"GO:0043933"(protein-containing complex organization)|go:"GO:0045104"(intermediate filament cytoskeleton organization)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0045214"(sarcomere organization)|go:"GO:0045296"(cadherin binding)|go:"GO:0045445"(myoblast differentiation)|go:"GO:0048471"(perinuclear region of cytoplasm)|ensembl:ENSG00000178209(gene)|ensembl:ENST00000322810(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0002162"(dystroglycan binding)|go:"GO:0002522"(leukocyte migration involved in immune response)|go:"GO:0003334"(keratinocyte development)|go:"GO:0003723"(RNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005737"(cytoplasm)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0061436"(establishment of skin barrier)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070584"(mitochondrion morphogenesis)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071464"(cellular response to hydrostatic pressure)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0120193"(tight junction organization)|go:"GO:2000689"(actomyosin contractile ring assembly actin filament organization)|go:"GO:2000983"(regulation of ATP citrate synthase activity)|interpro:IPR001101(Plectin repeat)|interpro:IPR001452(Src homology-3)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR005326(Plectin/S10, N-terminal)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005925"(focal adhesion)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006997"(nucleus organization)|go:"GO:0008307"(structural constituent of muscle)|go:"GO:0010467"(gene expression)|go:"GO:0010761"(fibroblast migration)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0014866"(skeletal myofibril assembly)|go:"GO:0016020"(membrane)|go:"GO:0016528"(sarcoplasm)|go:"GO:0016569"(obsolete covalent chromatin modification)|go:"GO:0019226"(transmission of nerve impulse)|interpro:IPR030269|interpro:IPR035915|interpro:IPR018159|interpro:IPR036388|interpro:IPR036872|interpro:IPR041573|interpro:IPR041615|interpro:IPR043197|mint:Q15149|rcsb pdb:1MB8|rcsb pdb:2N03|rcsb pdb:2ODU|rcsb pdb:2ODV|rcsb pdb:3F7P|rcsb pdb:3PDY|rcsb pdb:3PE0|rcsb pdb:4GDO|rcsb pdb:4Q58|rcsb pdb:4Q59|rcsb pdb:5J1F|rcsb pdb:5J1G|rcsb pdb:5J1H|rcsb pdb:5J1I|reactome:R-HSA-2022090|reactome:R-HSA-264870|reactome:R-HSA-446107|ensembl:ENST00000436759|ensembl:ENSP00000388180|ensembl:ENST00000527096|ensembl:ENSP00000434583|ensembl:ENSP00000323856|ensembl:ENST00000345136|ensembl:ENSP00000344848|ensembl:ENST00000354589|ensembl:ENSP00000346602|ensembl:ENST00000354958|ensembl:ENSP00000347044|ensembl:ENST00000356346|ensembl:ENSP00000348702|ensembl:ENST00000357649|ensembl:ENSP00000350277|ensembl:ENST00000398774|ensembl:ENSP00000381756|refseq:NP_000436.2|refseq:NP_958780.1|refseq:NP_958781.1|refseq:NP_958782.1|refseq:NP_958783.1|refseq:NP_958784.1|refseq:NP_958785.1|refseq:NP_958786.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/04/15 rogid:2q3q4qXEhEU25TR01JaiCy1T8HE9606 rogid:zbctDAOOCaJUx3WBdp85v7SI0sI9606 intact-crc:27224B9090B3D142|rigid:yjNxrwv8i5avaBpfN0XvlWC/AYE false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q504Q3 uniprotkb:Q15370 intact:EBI-1058976|uniprotkb:Q76E12|uniprotkb:O75189|uniprotkb:Q8IVE1|intact:EBI-2513034|ensembl:ENSP00000401721|ensembl:ENSP00000449861|ensembl:ENSP00000481859 intact:EBI-301238|ensembl:ENSP00000386652|uniprotkb:B7WPD3 psi-mi:pan2_human(display_long)|uniprotkb:PAN2(gene name)|psi-mi:PAN2(display_short)|uniprotkb:KIAA0710(gene name synonym)|uniprotkb:USP52(gene name synonym)|uniprotkb:Inactive ubiquitin carboxyl-terminal hydrolase 52(gene name synonym)|uniprotkb:"PAB1P-dependent poly(A)-specific ribonuclease"(gene name synonym)|uniprotkb:"Poly(A)-nuclease deadenylation complex subunit 2"(gene name synonym) psi-mi:elob_human(display_long)|uniprotkb:ELOB(gene name)|psi-mi:ELOB(display_short)|uniprotkb:Elongin 18 kDa subunit(gene name synonym)|uniprotkb:RNA polymerase II transcription factor SIII subunit B(gene name synonym)|uniprotkb:SIII p18(gene name synonym)|uniprotkb:TCEB2(gene name synonym)|uniprotkb:Transcription elongation factor B polypeptide 2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513052|imex:IM-12079-79 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001120932.1|refseq:NP_001159751.1|refseq:NP_055686.3|ensembl:ENSG00000135473(gene)|ensembl:ENST00000425394(transcript)|ensembl:ENST00000548043(transcript)|ensembl:ENST00000610546(transcript)|go:"GO:0000175"(3'-5'-exoribonuclease activity)|go:"GO:0000289"("nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0000932"(P-body)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0004535"("poly(A)-specific ribonuclease activity")|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006397"(mRNA processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010606"(positive regulation of cytoplasmic mRNA processing body assembly)|go:"GO:0031251"(PAN complex)|go:"GO:0046872"(metal ion binding)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR013520(Exonuclease, RNase T and DNA polymerase III)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR028881|interpro:IPR028889|interpro:IPR030843|interpro:IPR036322|interpro:IPR036397|interpro:IPR038765|reactome:R-HSA-429947|dip:DIP-50708N ensembl:ENSG00000103363(gene)|ensembl:ENST00000409906(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030891"(VCB complex)|go:"GO:0031462"(Cul2-RING ubiquitin ligase complex)|go:"GO:0031466"(Cul5-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070449"(elongin complex)|interpro:IPR000626(Ubiquitin)|interpro:IPR029071|interpro:IPR039049|mint:Q15370|rcsb pdb:1LM8|rcsb pdb:1LQB|rcsb pdb:1VCB|rcsb pdb:2C9W|rcsb pdb:2IZV|rcsb pdb:2JZ3|rcsb pdb:2MA9|rcsb pdb:3DCG|rcsb pdb:3ZKJ|rcsb pdb:3ZNG|rcsb pdb:3ZRC|rcsb pdb:3ZRF|rcsb pdb:3ZTC|rcsb pdb:3ZTD|rcsb pdb:3ZUN|rcsb pdb:4AJY|rcsb pdb:4AWJ|rcsb pdb:4B95|rcsb pdb:4B9K|rcsb pdb:4BKS|rcsb pdb:4BKT|rcsb pdb:4N9F|rcsb pdb:4W9C|rcsb pdb:4W9D|rcsb pdb:4W9E|rcsb pdb:4W9F|rcsb pdb:4W9G|rcsb pdb:4W9H|rcsb pdb:4W9I|rcsb pdb:4W9J|rcsb pdb:4W9K|rcsb pdb:4W9L|rcsb pdb:5BO4|rcsb pdb:5LLI|rcsb pdb:5N4W|rcsb pdb:5NVV|rcsb pdb:5NVW|rcsb pdb:5NVX|rcsb pdb:5NVY|rcsb pdb:5NVZ|rcsb pdb:5NW0|rcsb pdb:5NW1|rcsb pdb:5NW2|rcsb pdb:5T35|rcsb pdb:6BVB|rcsb pdb:6C5X|rcsb pdb:6FMI|rcsb pdb:6FMJ|rcsb pdb:6FMK|rcsb pdb:6GFX|rcsb pdb:6GFY|rcsb pdb:6GFZ|rcsb pdb:6GMN|rcsb pdb:6GMQ|rcsb pdb:6GMR|rcsb pdb:6GMX|rcsb pdb:4WQO|rcsb pdb:6HAX|rcsb pdb:6HAY|rcsb pdb:6HR2|rcsb pdb:6I4X|rcsb pdb:6I5J|rcsb pdb:6I5N|rcsb pdb:6I7Q|rcsb pdb:6I7R|rcsb pdb:6P59|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|rcsb pdb:6R7N|rcsb pdb:6V9H|rcsb pdb:6ZHC|rcsb pdb:7KHH|reactome:R-HSA-112382|reactome:R-HSA-1234176|reactome:R-HSA-167152|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-180585|reactome:R-HSA-674695|reactome:R-HSA-6796648|reactome:R-HSA-75955|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9705462|reactome:R-HSA-983168|rcsb pdb:6SIS|refseq:NP_009039.1|refseq:NP_996896.1|dip:DIP-29570N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/04/15 rogid:2q3q4qXEhEU25TR01JaiCy1T8HE9606 rogid:apX4QFpDC4Dz3MAs7tQ8+XFHx6I9606 intact-crc:27224B9090B3D142|rigid:yjNxrwv8i5avaBpfN0XvlWC/AYE false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q504Q3 uniprotkb:Q8IUF1 intact:EBI-1058976|uniprotkb:Q76E12|uniprotkb:O75189|uniprotkb:Q8IVE1|intact:EBI-2513034|ensembl:ENSP00000401721|ensembl:ENSP00000449861|ensembl:ENSP00000481859 intact:EBI-359159|uniprotkb:Q0VAN3|ensembl:ENSP00000259199 psi-mi:pan2_human(display_long)|uniprotkb:PAN2(gene name)|psi-mi:PAN2(display_short)|uniprotkb:KIAA0710(gene name synonym)|uniprotkb:USP52(gene name synonym)|uniprotkb:Inactive ubiquitin carboxyl-terminal hydrolase 52(gene name synonym)|uniprotkb:"PAB1P-dependent poly(A)-specific ribonuclease"(gene name synonym)|uniprotkb:"Poly(A)-nuclease deadenylation complex subunit 2"(gene name synonym) psi-mi:cbwd2_human(display_long)|uniprotkb:CBWD2(gene name)|psi-mi:CBWD2(display_short)|uniprotkb:Cobalamin synthase W domain-containing protein 2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513052|imex:IM-12079-79 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001120932.1|refseq:NP_001159751.1|refseq:NP_055686.3|ensembl:ENSG00000135473(gene)|ensembl:ENST00000425394(transcript)|ensembl:ENST00000548043(transcript)|ensembl:ENST00000610546(transcript)|go:"GO:0000175"(3'-5'-exoribonuclease activity)|go:"GO:0000289"("nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0000932"(P-body)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0004535"("poly(A)-specific ribonuclease activity")|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006397"(mRNA processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010606"(positive regulation of cytoplasmic mRNA processing body assembly)|go:"GO:0031251"(PAN complex)|go:"GO:0046872"(metal ion binding)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR013520(Exonuclease, RNase T and DNA polymerase III)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR028881|interpro:IPR028889|interpro:IPR030843|interpro:IPR036322|interpro:IPR036397|interpro:IPR038765|reactome:R-HSA-429947|dip:DIP-50708N refseq:NP_742000.1|ensembl:ENSG00000136682(gene)|ensembl:ENST00000259199(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|interpro:IPR003495("Cobalamin (vitamin B12) biosynthesis CobW-like")|interpro:IPR011629("Cobalamin (vitamin B12) biosynthesis CobW-like, C-terminal")|interpro:IPR027417|interpro:IPR036627|mint:Q8IUF1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/04/15 rogid:2q3q4qXEhEU25TR01JaiCy1T8HE9606 rogid:ySchikxhPpEEcH7X5FiA3JOtSHs9606 intact-crc:27224B9090B3D142|rigid:yjNxrwv8i5avaBpfN0XvlWC/AYE false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q504Q3 uniprotkb:Q8N1F7 intact:EBI-1058976|uniprotkb:Q76E12|uniprotkb:O75189|uniprotkb:Q8IVE1|intact:EBI-2513034|ensembl:ENSP00000401721|ensembl:ENSP00000449861|ensembl:ENSP00000481859 intact:EBI-1042703|uniprotkb:Q14705|uniprotkb:B3KPQ8|ensembl:ENSP00000310668 psi-mi:pan2_human(display_long)|uniprotkb:PAN2(gene name)|psi-mi:PAN2(display_short)|uniprotkb:KIAA0710(gene name synonym)|uniprotkb:USP52(gene name synonym)|uniprotkb:Inactive ubiquitin carboxyl-terminal hydrolase 52(gene name synonym)|uniprotkb:"PAB1P-dependent poly(A)-specific ribonuclease"(gene name synonym)|uniprotkb:"Poly(A)-nuclease deadenylation complex subunit 2"(gene name synonym) psi-mi:nup93_human(display_long)|uniprotkb:NUP93(gene name)|psi-mi:NUP93(display_short)|uniprotkb:KIAA0095(gene name synonym)|uniprotkb:Nucleoporin Nup93(gene name synonym)|uniprotkb:93 kDa nucleoporin(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513052|imex:IM-12079-79 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001120932.1|refseq:NP_001159751.1|refseq:NP_055686.3|ensembl:ENSG00000135473(gene)|ensembl:ENST00000425394(transcript)|ensembl:ENST00000548043(transcript)|ensembl:ENST00000610546(transcript)|go:"GO:0000175"(3'-5'-exoribonuclease activity)|go:"GO:0000289"("nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0000932"(P-body)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0004535"("poly(A)-specific ribonuclease activity")|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006397"(mRNA processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010606"(positive regulation of cytoplasmic mRNA processing body assembly)|go:"GO:0031251"(PAN complex)|go:"GO:0046872"(metal ion binding)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR013520(Exonuclease, RNase T and DNA polymerase III)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR028881|interpro:IPR028889|interpro:IPR030843|interpro:IPR036322|interpro:IPR036397|interpro:IPR038765|reactome:R-HSA-429947|dip:DIP-50708N refseq:NP_055484.3|refseq:NP_001229724.1|refseq:NP_001229725.1|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006998"(nuclear envelope organization)|go:"GO:0016020"(membrane)|go:"GO:0016973"("poly(A)+ mRNA export from nucleus")|go:"GO:0017056"(structural constituent of nuclear pore)|go:"GO:0031965"(nuclear membrane)|go:"GO:0034399"(nuclear periphery)|go:"GO:0051292"(nuclear pore complex assembly)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060395"(SMAD protein signal transduction)|interpro:IPR007231(Nucleoporin interacting component)|mint:Q8N1F7|rcsb pdb:5IJN|rcsb pdb:5IJO|reactome:R-HSA-1169408|reactome:R-HSA-159227|reactome:R-HSA-159230|reactome:R-HSA-159231|reactome:R-HSA-159236|reactome:R-HSA-165054|ensembl:ENSG00000102900(gene)|reactome:R-HSA-168271|ensembl:ENST00000308159(transcript)|go:"GO:0005635"(nuclear envelope)|reactome:R-HSA-168276|go:"GO:0005643"(nuclear pore)|reactome:R-HSA-168325|reactome:R-HSA-168333|reactome:R-HSA-170822|reactome:R-HSA-180746|reactome:R-HSA-180910|reactome:R-HSA-3108214|reactome:R-HSA-3232142|reactome:R-HSA-3301854|reactome:R-HSA-3371453|reactome:R-HSA-191859|reactome:R-HSA-4085377|reactome:R-HSA-4551638|reactome:R-HSA-4570464|reactome:R-HSA-4615885|reactome:R-HSA-5578749|reactome:R-HSA-5619107|reactome:R-HSA-6784531|reactome:R-HSA-9609690|reactome:R-HSA-9610379|reactome:R-HSA-9615933|refseq:XP_005256320.1|dip:DIP-44020N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/04/15 rogid:2q3q4qXEhEU25TR01JaiCy1T8HE9606 rogid:pkk5pooUC4yQShpqjiwNLddfy149606 intact-crc:27224B9090B3D142|rigid:yjNxrwv8i5avaBpfN0XvlWC/AYE false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q504Q3 uniprotkb:Q15369 intact:EBI-1058976|uniprotkb:Q76E12|uniprotkb:O75189|uniprotkb:Q8IVE1|intact:EBI-2513034|ensembl:ENSP00000401721|ensembl:ENSP00000449861|ensembl:ENSP00000481859 intact:EBI-301231|uniprotkb:Q567Q6|ensembl:ENSP00000284811|ensembl:ENSP00000428074|ensembl:ENSP00000428171|ensembl:ENSP00000428334|ensembl:ENSP00000429596|ensembl:ENSP00000429906|ensembl:ENSP00000478121|uniprotkb:E5RGD9 psi-mi:pan2_human(display_long)|uniprotkb:PAN2(gene name)|psi-mi:PAN2(display_short)|uniprotkb:KIAA0710(gene name synonym)|uniprotkb:USP52(gene name synonym)|uniprotkb:Inactive ubiquitin carboxyl-terminal hydrolase 52(gene name synonym)|uniprotkb:"PAB1P-dependent poly(A)-specific ribonuclease"(gene name synonym)|uniprotkb:"Poly(A)-nuclease deadenylation complex subunit 2"(gene name synonym) psi-mi:eloc_human(display_long)|uniprotkb:ELOC(gene name)|psi-mi:ELOC(display_short)|uniprotkb:Elongin 15 kDa subunit(gene name synonym)|uniprotkb:RNA polymerase II transcription factor SIII subunit C(gene name synonym)|uniprotkb:SIII p15(gene name synonym)|uniprotkb:TCEB1(gene name synonym)|uniprotkb:Transcription elongation factor B polypeptide 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513052|imex:IM-12079-79 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001120932.1|refseq:NP_001159751.1|refseq:NP_055686.3|ensembl:ENSG00000135473(gene)|ensembl:ENST00000425394(transcript)|ensembl:ENST00000548043(transcript)|ensembl:ENST00000610546(transcript)|go:"GO:0000175"(3'-5'-exoribonuclease activity)|go:"GO:0000289"("nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0000932"(P-body)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0004535"("poly(A)-specific ribonuclease activity")|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006397"(mRNA processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010606"(positive regulation of cytoplasmic mRNA processing body assembly)|go:"GO:0031251"(PAN complex)|go:"GO:0046872"(metal ion binding)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR013520(Exonuclease, RNase T and DNA polymerase III)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR028881|interpro:IPR028889|interpro:IPR030843|interpro:IPR036322|interpro:IPR036397|interpro:IPR038765|reactome:R-HSA-429947|dip:DIP-50708N refseq:NP_005639.1|refseq:NP_001191786.1|refseq:NP_001191787.1|refseq:NP_001191788.1|refseq:NP_001191789.1|refseq:NP_001191790.1|refseq:NP_001191791.1|refseq:NP_001191792.1|refseq:NP_001191793.1|ensembl:ENSG00000154582(gene)|ensembl:ENST00000284811(transcript)|ensembl:ENST00000518127(transcript)|ensembl:ENST00000519487(transcript)|ensembl:ENST00000520242(transcript)|ensembl:ENST00000522337(transcript)|ensembl:ENST00000523815(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0031462"(Cul2-RING ubiquitin ligase complex)|go:"GO:0070449"(elongin complex)|interpro:IPR001232(SKP1 component)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR016073(SKP1 component, POZ)|interpro:IPR039948|mint:Q15369|rcsb pdb:1LM8|rcsb pdb:1LQB|rcsb pdb:1VCB|rcsb pdb:2C9W|rcsb pdb:2IZV|rcsb pdb:2MA9|rcsb pdb:3DCG|rcsb pdb:3ZKJ|rcsb pdb:3ZNG|rcsb pdb:3ZRC|rcsb pdb:3ZRF|rcsb pdb:3ZTC|rcsb pdb:3ZTD|rcsb pdb:3ZUN|rcsb pdb:4AJY|rcsb pdb:4AWJ|ensembl:ENST00000622804(transcript)|rcsb pdb:4B95|rcsb pdb:4B9K|rcsb pdb:4BKS|rcsb pdb:4BKT|rcsb pdb:4N9F|rcsb pdb:4W9C|rcsb pdb:4W9D|rcsb pdb:4W9E|rcsb pdb:4W9F|rcsb pdb:4W9G|rcsb pdb:4W9H|rcsb pdb:4W9I|rcsb pdb:4W9J|rcsb pdb:4W9K|rcsb pdb:4W9L|rcsb pdb:4WQO|rcsb pdb:5BO4|rcsb pdb:5LLI|rcsb pdb:5N4W|rcsb pdb:5NVV|rcsb pdb:5NVW|rcsb pdb:5NVX|rcsb pdb:5NVY|rcsb pdb:5NVZ|rcsb pdb:5NW0|rcsb pdb:5NW1|rcsb pdb:5NW2|rcsb pdb:5T35|rcsb pdb:6BVB|rcsb pdb:6C5X|rcsb pdb:6FMI|rcsb pdb:6FMJ|rcsb pdb:6FMK|rcsb pdb:6GFX|rcsb pdb:6GFZ|rcsb pdb:6GMN|rcsb pdb:6GMQ|rcsb pdb:6GMR|rcsb pdb:6GMX|rcsb pdb:6HAX|rcsb pdb:6GFY|rcsb pdb:6HAY|rcsb pdb:6HR2|rcsb pdb:6I4X|rcsb pdb:6I5J|rcsb pdb:6I5N|rcsb pdb:6I7R|rcsb pdb:6P59|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7N|rcsb pdb:6SIS|rcsb pdb:6V9H|rcsb pdb:6ZHC|rcsb pdb:7KHH|reactome:R-HSA-112382|reactome:R-HSA-1234176|reactome:R-HSA-167152|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-180585|reactome:R-HSA-674695|reactome:R-HSA-6796648|reactome:R-HSA-75955|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9705462|reactome:R-HSA-983168|reactome:R-HSA-167200|refseq:XP_011515882.1|refseq:XP_011515883.1|dip:DIP-29571N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/04/15 rogid:2q3q4qXEhEU25TR01JaiCy1T8HE9606 rogid:Ngvkh3YoddZoutF3Vgwdi2b6xz49606 intact-crc:27224B9090B3D142|rigid:yjNxrwv8i5avaBpfN0XvlWC/AYE false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q504Q3 uniprotkb:Q58A45 intact:EBI-1058976|uniprotkb:Q76E12|uniprotkb:O75189|uniprotkb:Q8IVE1|intact:EBI-2513034|ensembl:ENSP00000401721|ensembl:ENSP00000449861|ensembl:ENSP00000481859 intact:EBI-2513054|uniprotkb:B7Z3W7|ensembl:ENSP00000370345|uniprotkb:Q76E13|uniprotkb:Q8NBA6|uniprotkb:A1A4Y9|uniprotkb:Q5T515|uniprotkb:Q5T516|uniprotkb:Q5HYG6|uniprotkb:Q5TBA0|uniprotkb:B1ALF1|uniprotkb:A0N0X1|uniprotkb:A1A4Y8|uniprotkb:Q0D2P2 psi-mi:pan2_human(display_long)|uniprotkb:PAN2(gene name)|psi-mi:PAN2(display_short)|uniprotkb:KIAA0710(gene name synonym)|uniprotkb:USP52(gene name synonym)|uniprotkb:Inactive ubiquitin carboxyl-terminal hydrolase 52(gene name synonym)|uniprotkb:"PAB1P-dependent poly(A)-specific ribonuclease"(gene name synonym)|uniprotkb:"Poly(A)-nuclease deadenylation complex subunit 2"(gene name synonym) psi-mi:pan3_human(display_long)|uniprotkb:PAN3(gene name)|psi-mi:PAN3(display_short)|uniprotkb:"PAB1P-dependent poly(A)-specific ribonuclease"(gene name synonym)|uniprotkb:"Poly(A)-nuclease deadenylation complex subunit 3"(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513052|imex:IM-12079-79 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001120932.1|refseq:NP_001159751.1|refseq:NP_055686.3|ensembl:ENSG00000135473(gene)|ensembl:ENST00000425394(transcript)|ensembl:ENST00000548043(transcript)|ensembl:ENST00000610546(transcript)|go:"GO:0000175"(3'-5'-exoribonuclease activity)|go:"GO:0000289"("nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0000932"(P-body)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0004535"("poly(A)-specific ribonuclease activity")|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006397"(mRNA processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010606"(positive regulation of cytoplasmic mRNA processing body assembly)|go:"GO:0031251"(PAN complex)|go:"GO:0046872"(metal ion binding)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR013520(Exonuclease, RNase T and DNA polymerase III)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR028881|interpro:IPR028889|interpro:IPR030843|interpro:IPR036322|interpro:IPR036397|interpro:IPR038765|reactome:R-HSA-429947|dip:DIP-50708N ensembl:ENSG00000152520(gene)|ensembl:ENST00000380958(transcript)|go:"GO:0000289"("nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0000932"(P-body)|go:"GO:0003723"(RNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006397"(mRNA processing)|go:"GO:0010606"(positive regulation of cytoplasmic mRNA processing body assembly)|go:"GO:0031251"(PAN complex)|go:"GO:0046872"(metal ion binding)|go:"GO:0090503"(RNA phosphodiester bond hydrolysis, exonucleolytic)|interpro:IPR000571(Zinc finger, CCCH-type)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR030844|interpro:IPR036855|interpro:IPR041332|reactome:R-HSA-429947|mint:Q58A45|refseq:NP_787050.6|ensembl:ENSP00000370345|refseq:XP_005266390.1|refseq:XP_005266391.1|refseq:XP_016876021.1|refseq:XP_016876022.1|dip:DIP-53755N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/04/15 rogid:2q3q4qXEhEU25TR01JaiCy1T8HE9606 rogid:mwXI4k9hdjdxaPRQ9UXH7pC7nuQ9606 intact-crc:27224B9090B3D142|rigid:yjNxrwv8i5avaBpfN0XvlWC/AYE false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q504Q3 uniprotkb:Q99832 intact:EBI-1058976|uniprotkb:Q76E12|uniprotkb:O75189|uniprotkb:Q8IVE1|intact:EBI-2513034|ensembl:ENSP00000401721|ensembl:ENSP00000449861|ensembl:ENSP00000481859 intact:EBI-357046|uniprotkb:B7WNW9|uniprotkb:O14871|uniprotkb:Q6FI26|uniprotkb:A8K7E6|uniprotkb:A8MWI8|uniprotkb:B7Z4T9|uniprotkb:B7Z4Z7|ensembl:ENSP00000258091 psi-mi:pan2_human(display_long)|uniprotkb:PAN2(gene name)|psi-mi:PAN2(display_short)|uniprotkb:KIAA0710(gene name synonym)|uniprotkb:USP52(gene name synonym)|uniprotkb:Inactive ubiquitin carboxyl-terminal hydrolase 52(gene name synonym)|uniprotkb:"PAB1P-dependent poly(A)-specific ribonuclease"(gene name synonym)|uniprotkb:"Poly(A)-nuclease deadenylation complex subunit 2"(gene name synonym) psi-mi:tcph_human(display_long)|uniprotkb:CCT7(gene name)|psi-mi:CCT7(display_short)|uniprotkb:CCTH(gene name synonym)|uniprotkb:NIP7-1(gene name synonym)|uniprotkb:CCT-eta(gene name synonym)|uniprotkb:HIV-1 Nef-interacting protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513052|imex:IM-12079-79 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001120932.1|refseq:NP_001159751.1|refseq:NP_055686.3|ensembl:ENSG00000135473(gene)|ensembl:ENST00000425394(transcript)|ensembl:ENST00000548043(transcript)|ensembl:ENST00000610546(transcript)|go:"GO:0000175"(3'-5'-exoribonuclease activity)|go:"GO:0000289"("nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0000932"(P-body)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0004535"("poly(A)-specific ribonuclease activity")|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006397"(mRNA processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010606"(positive regulation of cytoplasmic mRNA processing body assembly)|go:"GO:0031251"(PAN complex)|go:"GO:0046872"(metal ion binding)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR013520(Exonuclease, RNase T and DNA polymerase III)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR028881|interpro:IPR028889|interpro:IPR030843|interpro:IPR036322|interpro:IPR036397|interpro:IPR038765|reactome:R-HSA-429947|dip:DIP-50708N dip:DIP-51608N|refseq:NP_006420.1|refseq:XP_011530780.1|refseq:XP_011530781.1|refseq:NP_001009570.1|refseq:NP_001159756.1|refseq:NP_001159757.1|ensembl:ENSG00000135624(gene)|ensembl:ENST00000258091(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005832"(chaperonin-containing T-complex)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0044297"(cell body)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1901998"(toxin transport)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|go:"GO:1904871"(positive regulation of protein localization to Cajal body)|go:"GO:1904874"(positive regulation of telomerase RNA localization to Cajal body)|interpro:IPR002194(Chaperonin TCP-1, conserved site)|interpro:IPR002423(Chaperonin Cpn60/TCP-1)|interpro:IPR012720(T-complex protein 1, eta subunit)|interpro:IPR017998|interpro:IPR027409|interpro:IPR027410|interpro:IPR027413|mint:Q99832|rcsb pdb:6NR8|rcsb pdb:6NR9|rcsb pdb:6NRA|rcsb pdb:6NRB|rcsb pdb:6NRC|rcsb pdb:6NRD|rcsb pdb:6QB8|rcsb pdb:7LUM|rcsb pdb:7LUP|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-390450|reactome:R-HSA-390471|reactome:R-HSA-6814122|reactome:R-HSA-9013418|reactome:R-HSA-9013422 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/04/15 rogid:2q3q4qXEhEU25TR01JaiCy1T8HE9606 rogid:buiW7iGdAbfcld/zMJOrkR2jxRo9606 intact-crc:27224B9090B3D142|rigid:yjNxrwv8i5avaBpfN0XvlWC/AYE false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q504Q3 uniprotkb:P61758 intact:EBI-1058976|uniprotkb:Q76E12|uniprotkb:O75189|uniprotkb:Q8IVE1|intact:EBI-2513034|ensembl:ENSP00000401721|ensembl:ENSP00000449861|ensembl:ENSP00000481859 intact:EBI-357430|ensembl:ENSP00000286428|uniprotkb:Q15765|uniprotkb:O55228|uniprotkb:Q5JT81|uniprotkb:Q86X96|uniprotkb:B2R8L5|uniprotkb:B4DWR3|uniprotkb:F5H2A7 psi-mi:pan2_human(display_long)|uniprotkb:PAN2(gene name)|psi-mi:PAN2(display_short)|uniprotkb:KIAA0710(gene name synonym)|uniprotkb:USP52(gene name synonym)|uniprotkb:Inactive ubiquitin carboxyl-terminal hydrolase 52(gene name synonym)|uniprotkb:"PAB1P-dependent poly(A)-specific ribonuclease"(gene name synonym)|uniprotkb:"Poly(A)-nuclease deadenylation complex subunit 2"(gene name synonym) psi-mi:pfd3_human(display_long)|uniprotkb:VBP1(gene name)|psi-mi:VBP1(display_short)|uniprotkb:PFDN3(gene name synonym)|uniprotkb:von Hippel-Lindau-binding protein 1(gene name synonym)|uniprotkb:HIBBJ46(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513052|imex:IM-12079-79 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001120932.1|refseq:NP_001159751.1|refseq:NP_055686.3|ensembl:ENSG00000135473(gene)|ensembl:ENST00000425394(transcript)|ensembl:ENST00000548043(transcript)|ensembl:ENST00000610546(transcript)|go:"GO:0000175"(3'-5'-exoribonuclease activity)|go:"GO:0000289"("nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0000932"(P-body)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0004535"("poly(A)-specific ribonuclease activity")|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006397"(mRNA processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010606"(positive regulation of cytoplasmic mRNA processing body assembly)|go:"GO:0031251"(PAN complex)|go:"GO:0046872"(metal ion binding)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR013520(Exonuclease, RNase T and DNA polymerase III)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR028881|interpro:IPR028889|interpro:IPR030843|interpro:IPR036322|interpro:IPR036397|interpro:IPR038765|reactome:R-HSA-429947|dip:DIP-50708N ensembl:ENSG00000155959(gene)|ensembl:ENST00000286428(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006457"(protein folding)|go:"GO:0007017"(microtubule-based process)|go:"GO:0007021"(tubulin complex assembly)|go:"GO:0015631"(tubulin binding)|go:"GO:0016272"(prefoldin complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0051082"(unfolded protein binding)|go:"GO:1905907"(negative regulation of amyloid fibril formation)|interpro:IPR004127(Prefoldin alpha-like)|interpro:IPR009053(Prefoldin)|interpro:IPR016655(Prefoldin, subunit 3)|mint:P61758|rcsb pdb:6NR8|rcsb pdb:6NR9|rcsb pdb:6NRB|rcsb pdb:6NRC|rcsb pdb:6NRD|reactome:R-HSA-389957|refseq:NP_003363.1|refseq:NP_001290472.1|refseq:NP_001290474.1|dip:DIP-46479N|refseq:NP_001290473.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/04/15 rogid:2q3q4qXEhEU25TR01JaiCy1T8HE9606 rogid:wHq+HRvhqfKwOaKtONGJdfETQxo9606 intact-crc:27224B9090B3D142|rigid:yjNxrwv8i5avaBpfN0XvlWC/AYE false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q504Q3 uniprotkb:Q9UHV9 intact:EBI-1058976|uniprotkb:Q76E12|uniprotkb:O75189|uniprotkb:Q8IVE1|intact:EBI-2513034|ensembl:ENSP00000401721|ensembl:ENSP00000449861|ensembl:ENSP00000481859 intact:EBI-359873|uniprotkb:Q9P0P7|uniprotkb:Q9UN05|ensembl:ENSP00000356989 psi-mi:pan2_human(display_long)|uniprotkb:PAN2(gene name)|psi-mi:PAN2(display_short)|uniprotkb:KIAA0710(gene name synonym)|uniprotkb:USP52(gene name synonym)|uniprotkb:Inactive ubiquitin carboxyl-terminal hydrolase 52(gene name synonym)|uniprotkb:"PAB1P-dependent poly(A)-specific ribonuclease"(gene name synonym)|uniprotkb:"Poly(A)-nuclease deadenylation complex subunit 2"(gene name synonym) psi-mi:pfd2_human(display_long)|uniprotkb:HSPC231(orf name)|uniprotkb:PFDN2(gene name)|psi-mi:PFDN2(display_short)|uniprotkb:PFD2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513052|imex:IM-12079-79 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001120932.1|refseq:NP_001159751.1|refseq:NP_055686.3|ensembl:ENSG00000135473(gene)|ensembl:ENST00000425394(transcript)|ensembl:ENST00000548043(transcript)|ensembl:ENST00000610546(transcript)|go:"GO:0000175"(3'-5'-exoribonuclease activity)|go:"GO:0000289"("nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0000932"(P-body)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0004535"("poly(A)-specific ribonuclease activity")|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006397"(mRNA processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010606"(positive regulation of cytoplasmic mRNA processing body assembly)|go:"GO:0031251"(PAN complex)|go:"GO:0046872"(metal ion binding)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR013520(Exonuclease, RNase T and DNA polymerase III)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR028881|interpro:IPR028889|interpro:IPR030843|interpro:IPR036322|interpro:IPR036397|interpro:IPR038765|reactome:R-HSA-429947|dip:DIP-50708N refseq:NP_036526.2|refseq:XP_011507926.1|ensembl:ENSG00000143256(gene)|ensembl:ENST00000368010(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0016272"(prefoldin complex)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051495"(positive regulation of cytoskeleton organization)|go:"GO:1905907"(negative regulation of amyloid fibril formation)|interpro:IPR002777(Prefoldin beta-like)|interpro:IPR009053(Prefoldin)|interpro:IPR027235|mint:Q9UHV9|rcsb pdb:6NR8|rcsb pdb:6NR9|rcsb pdb:6NRB|rcsb pdb:6NRC|rcsb pdb:6NRD|reactome:R-HSA-389957|dip:DIP-27557N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/04/15 rogid:2q3q4qXEhEU25TR01JaiCy1T8HE9606 rogid:rgr14h3vGyzHxHoNJtlHBQkvhUE9606 intact-crc:27224B9090B3D142|rigid:yjNxrwv8i5avaBpfN0XvlWC/AYE false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q504Q3 uniprotkb:Q9NYK5 intact:EBI-1058976|uniprotkb:Q76E12|uniprotkb:O75189|uniprotkb:Q8IVE1|intact:EBI-2513034|ensembl:ENSP00000401721|ensembl:ENSP00000449861|ensembl:ENSP00000481859 intact:EBI-2513042|ensembl:ENSP00000284967|uniprotkb:Q9BZV6|uniprotkb:Q32Q74|uniprotkb:Q9BSQ7|uniprotkb:Q5QTR3|uniprotkb:Q96Q65|uniprotkb:Q9NX44|uniprotkb:C9JYA5 psi-mi:pan2_human(display_long)|uniprotkb:PAN2(gene name)|psi-mi:PAN2(display_short)|uniprotkb:KIAA0710(gene name synonym)|uniprotkb:USP52(gene name synonym)|uniprotkb:Inactive ubiquitin carboxyl-terminal hydrolase 52(gene name synonym)|uniprotkb:"PAB1P-dependent poly(A)-specific ribonuclease"(gene name synonym)|uniprotkb:"Poly(A)-nuclease deadenylation complex subunit 2"(gene name synonym) psi-mi:rm39_human(display_long)|uniprotkb:MRPL39(gene name)|psi-mi:MRPL39(display_short)|uniprotkb:C21orf92(gene name synonym)|uniprotkb:MRPL5(gene name synonym)|uniprotkb:RPML5(gene name synonym)|uniprotkb:39S ribosomal protein L5, mitochondrial(gene name synonym)|uniprotkb:MSTP003(orf name)|uniprotkb:PRED22(orf name)|uniprotkb:Mitochondrial large ribosomal subunit protein mL39(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513052|imex:IM-12079-79 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001120932.1|refseq:NP_001159751.1|refseq:NP_055686.3|ensembl:ENSG00000135473(gene)|ensembl:ENST00000425394(transcript)|ensembl:ENST00000548043(transcript)|ensembl:ENST00000610546(transcript)|go:"GO:0000175"(3'-5'-exoribonuclease activity)|go:"GO:0000289"("nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0000932"(P-body)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0004535"("poly(A)-specific ribonuclease activity")|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006397"(mRNA processing)|go:"GO:0006508"(proteolysis)|go:"GO:0010606"(positive regulation of cytoplasmic mRNA processing body assembly)|go:"GO:0031251"(PAN complex)|go:"GO:0046872"(metal ion binding)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR013520(Exonuclease, RNase T and DNA polymerase III)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR028881|interpro:IPR028889|interpro:IPR030843|interpro:IPR036322|interpro:IPR036397|interpro:IPR038765|reactome:R-HSA-429947|dip:DIP-50708N ensembl:ENSG00000154719(gene)|ensembl:ENST00000352957(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005761"(mitochondrial ribosome)|go:"GO:0005762"(mitochondrial large ribosomal subunit)|interpro:IPR004095(TGS)|interpro:IPR012675(Beta-grasp fold, ferredoxin-type)|interpro:IPR012676(TGS-like)|interpro:IPR018163|mint:Q9NYK5|rcsb pdb:3J7Y|rcsb pdb:3J9M|rcsb pdb:5OOL|rcsb pdb:5OOM|rcsb pdb:6I9R|rcsb pdb:6NU2|rcsb pdb:6VLZ|rcsb pdb:6VMI|rcsb pdb:6ZM5|rcsb pdb:6ZM6|rcsb pdb:6ZS9|rcsb pdb:6ZSA|rcsb pdb:6ZSB|rcsb pdb:6ZSC|rcsb pdb:6ZSD|rcsb pdb:6ZSE|rcsb pdb:6ZSG|rcsb pdb:7A5F|rcsb pdb:7A5G|rcsb pdb:7A5H|rcsb pdb:7A5I|rcsb pdb:7A5J|rcsb pdb:7A5K|rcsb pdb:7L08|rcsb pdb:7L20|rcsb pdb:7O9K|rcsb pdb:7O9M|rcsb pdb:7ODR|rcsb pdb:7ODS|rcsb pdb:7ODT|rcsb pdb:7OF0|rcsb pdb:7OF2|rcsb pdb:7OF3|rcsb pdb:7OF4|rcsb pdb:7OF5|rcsb pdb:7OF6|rcsb pdb:7OF7|rcsb pdb:7OG4|reactome:R-HSA-5368286|reactome:R-HSA-5389840|reactome:R-HSA-5419276|rcsb pdb:6NU3|refseq:NP_059142.2|refseq:NP_542984.2|refseq:XP_006724089.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/04/15 rogid:2q3q4qXEhEU25TR01JaiCy1T8HE9606 rogid:yolHEKnYRC1KwprZYyWZXZmjgr89606 intact-crc:27224B9090B3D142|rigid:yjNxrwv8i5avaBpfN0XvlWC/AYE false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P45974 uniprotkb:Q92995 intact:EBI-741277|ensembl:ENSP00000229268|uniprotkb:Q96J22|uniprotkb:D3DUS7|uniprotkb:D3DUS8 intact:EBI-714351|uniprotkb:D3DNS2|uniprotkb:Q96B25|intact:EBI-28978985|ensembl:ENSP00000263966|uniprotkb:A8K2S3|uniprotkb:B4DYF3 psi-mi:ubp5_human(display_long)|uniprotkb:Ubiquitin-specific-processing protease 5(gene name synonym)|uniprotkb:Deubiquitinating enzyme 5(gene name synonym)|uniprotkb:Isopeptidase T(gene name synonym)|uniprotkb:USP5(gene name)|psi-mi:USP5(display_short)|uniprotkb:ISOT(gene name synonym)|uniprotkb:Ubiquitin thioesterase 5(gene name synonym) psi-mi:ubp13_human(display_long)|uniprotkb:Ubiquitin-specific-processing protease 13(gene name synonym)|uniprotkb:Deubiquitinating enzyme 13(gene name synonym)|uniprotkb:Isopeptidase T-3(gene name synonym)|uniprotkb:USP13(gene name)|psi-mi:USP13(display_short)|uniprotkb:ISOT3(gene name synonym)|uniprotkb:Ubiquitin thioesterase 13(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513097|imex:IM-12079-28 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000111667(gene)|ensembl:ENST00000229268(transcript)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005764"(lysosome)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0071108"(protein K48-linked deubiquitination)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR009060(UBA-like)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR016652(Ubiquitinyl hydrolase)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|interpro:IPR041432|interpro:IPR041812|mint:P45974|rcsb pdb:2DAG|rcsb pdb:2DAK|rcsb pdb:2G43|rcsb pdb:2G45|rcsb pdb:3IHP|rcsb pdb:6DXH|rcsb pdb:6DXT|rcsb pdb:6NFT|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|rcsb pdb:6P9G|rcsb pdb:7MS5|rcsb pdb:7MS6|rcsb pdb:7MS7|reactome:R-HSA-5689880|reactome:R-HSA-8866652|refseq:NP_001092006.1|refseq:NP_003472.2|dip:DIP-34459N refseq:NP_003931.2|ensembl:ENSG00000058056(gene)|ensembl:ENST00000263966(transcript)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006914"(autophagy)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030318"(melanocyte differentiation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035523"(protein K29-linked deubiquitination)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0044313"(protein K6-linked deubiquitination)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0070628"(proteasome binding)|go:"GO:1904288"(BAT3 complex binding)|go:"GO:1904294"(positive regulation of ERAD pathway)|go:"GO:1904378"(maintenance of unfolded protein involved in ERAD pathway)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR009060(UBA-like)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR016652(Ubiquitinyl hydrolase)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|interpro:IPR041432|rcsb pdb:2L80|rcsb pdb:2LBC|reactome:R-HSA-5689880|reactome:R-HSA-8948751|ensembl:ENSP00000263966|ensembl:ENST00000496897|ensembl:ENSP00000417146|dip:DIP-53511N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:9wmOnaEu1N5ZY3E4UiHp2D9f9j89606 rogid:q6g2QmSYm3Xjoo+tv20s6cN8iHk9606 intact-crc:471D5544343B3DDD|rigid:qUBJ7KBzwp0R2RmpRqZtYydNDEU false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q93009 uniprotkb:Q7Z6Z7 intact:EBI-302474|uniprotkb:A6NMY8|intact:EBI-28988230|ensembl:ENSP00000343535|uniprotkb:B7Z815|uniprotkb:H0Y3G8 intact:EBI-625934|uniprotkb:O15029|uniprotkb:Q4G2Z2|uniprotkb:Q5H961|uniprotkb:Q6P4D0|uniprotkb:Q8NG67|uniprotkb:Q9BUI0|uniprotkb:Q9HCJ4|uniprotkb:Q9NSL6|uniprotkb:Q9P0A9|ensembl:ENSP00000262854|ensembl:ENSP00000340648 psi-mi:ubp7_human(display_long)|uniprotkb:USP7(gene name)|psi-mi:USP7(display_short)|uniprotkb:HAUSP(gene name synonym)|uniprotkb:Ubiquitin thioesterase 7(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 7(gene name synonym)|uniprotkb:Deubiquitinating enzyme 7(gene name synonym)|uniprotkb:Herpesvirus-associated ubiquitin-specific protease(gene name synonym) psi-mi:huwe1_human(display_long)|uniprotkb:HECT, UBA and WWE domain-containing protein 1(gene name synonym)|uniprotkb:Upstream regulatory element-binding protein 1(gene name synonym)|uniprotkb:Mcl-1 ubiquitin ligase E3(gene name synonym)|uniprotkb:ARF-binding protein 1(gene name synonym)|uniprotkb:Large structure of UREB1(gene name synonym)|uniprotkb:Homologous to E6AP carboxyl terminus homologous protein 9(gene name synonym)|uniprotkb:HUWE1(gene name)|psi-mi:HUWE1(display_short)|uniprotkb:KIAA0312(gene name synonym)|uniprotkb:KIAA1578(gene name synonym)|uniprotkb:HSPC272(orf name)|uniprotkb:HECT-type E3 ubiquitin transferase HUWE1(gene name synonym)|uniprotkb:UREB1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513133|imex:IM-12079-80 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:4PYZ|rcsb pdb:4WPH|rcsb pdb:4WPI|rcsb pdb:4YOC|rcsb pdb:4YSI|rcsb pdb:4Z96|rcsb pdb:4Z97|rcsb pdb:5C56|rcsb pdb:5C6D|rcsb pdb:5FWI|rcsb pdb:5GG4|rcsb pdb:5J7T|rcsb pdb:5JTJ|rcsb pdb:5JTV|rcsb pdb:5KYB|rcsb pdb:4M5X|rcsb pdb:5KYC|rcsb pdb:5KYD|rcsb pdb:5KYE|rcsb pdb:5KYF|interpro:IPR029346|interpro:IPR038765|mint:Q93009|rcsb pdb:1NB8|rcsb pdb:1NBF|rcsb pdb:1YY6|rcsb pdb:1YZE|rcsb pdb:2F1W|rcsb pdb:2F1X|rcsb pdb:2F1Y|rcsb pdb:2F1Z|rcsb pdb:2FOJ|rcsb pdb:2FOO|rcsb pdb:2FOP|rcsb pdb:2KVR|rcsb pdb:2XXN|rcsb pdb:2YLM|rcsb pdb:3MQR|rcsb pdb:3MQS|rcsb pdb:4JJQ|rcsb pdb:4KG9|rcsb pdb:4M5W|go:"GO:0006283"(transcription-coupled nucleotide-excision repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010216"(maintenance of DNA methylation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035520"(monoubiquitinated protein deubiquitination)|go:"GO:0035616"(histone H2B conserved C-terminal lysine deubiquitination)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0048511"(rhythmic process)|go:"GO:0050821"(protein stabilization)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0101005"(deubiquitinase activity)|go:"GO:1901537"(positive regulation of DNA demethylation)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1904353"(regulation of telomere capping)|go:"GO:1905279"(regulation of retrograde transport, endosome to Golgi)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR018200|interpro:IPR024729|interpro:IPR028889|ensembl:ENSG00000187555(gene)|ensembl:ENST00000344836(transcript)|go:"GO:0002039"(p53 binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0006111"(regulation of gluconeogenesis)|rcsb pdb:5N9R|rcsb pdb:5N9T|rcsb pdb:5NGE|rcsb pdb:5NGF|rcsb pdb:5UQV|rcsb pdb:5UQX|rcsb pdb:5VS6|rcsb pdb:5VSB|rcsb pdb:5VSK|rcsb pdb:5WHC|rcsb pdb:6F5H|rcsb pdb:6M1K|rcsb pdb:6P5L|rcsb pdb:6VN2|rcsb pdb:6VN3|rcsb pdb:6VN4|rcsb pdb:6VN5|rcsb pdb:6VN6|rcsb pdb:7CM2|reactome:R-HSA-5689880|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6804757|reactome:R-HSA-8866652|reactome:R-HSA-8948747|refseq:NP_001273386.1|refseq:NP_003461.2|refseq:NP_001308787.1|ensembl:ENSP00000343535|ensembl:ENST00000381886|ensembl:ENSP00000371310|dip:DIP-29053N ensembl:ENSG00000086758(gene)|ensembl:ENST00000262854(transcript)|ensembl:ENST00000342160(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006284"(base-excision repair)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0007030"(Golgi organization)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0030154"(cell differentiation)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000569(HECT)|interpro:IPR004170(WWE)|interpro:IPR009060(UBA-like)|interpro:IPR010309(E3 ubiquitin ligase, region of unknown function DUF908)|interpro:IPR010314(E3 ubiquitin ligase, region of unknown function DUF913)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR025527|interpro:IPR035983|interpro:IPR037197|interpro:IPR041918|mint:Q7Z6Z7|rcsb pdb:2EKK|rcsb pdb:2MUL|rcsb pdb:3G1N|go:"GO:0061025"(membrane fusion)|rcsb pdb:5C6H|rcsb pdb:5LP8|rcsb pdb:6FYH|rcsb pdb:6MIW|rcsb pdb:6PFL|reactome:R-HSA-6798695|rcsb pdb:3H1D|reactome:R-HSA-983168|refseq:NP_113584.3|refseq:XP_005262022.1|dip:DIP-34362N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:V+PXXBRM2zwlGQaeFiyjaQ9yf+A9606 rogid:TnIn0mcFc81bJlMkyWTtq3n/uOg9606 intact-crc:0247E0A3D2DA0BA0|rigid:YNzZdLlQUWY3+HOVHH44/ctr6C4 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q93009 uniprotkb:Q14669 intact:EBI-302474|uniprotkb:A6NMY8|intact:EBI-28988230|ensembl:ENSP00000343535|uniprotkb:B7Z815|uniprotkb:H0Y3G8 intact:EBI-308443|uniprotkb:Q15644|ensembl:ENSP00000283943|uniprotkb:D4HL82|uniprotkb:Q14CA3|uniprotkb:Q14CF1|uniprotkb:Q53R87|uniprotkb:Q53TE7 psi-mi:ubp7_human(display_long)|uniprotkb:USP7(gene name)|psi-mi:USP7(display_short)|uniprotkb:HAUSP(gene name synonym)|uniprotkb:Ubiquitin thioesterase 7(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 7(gene name synonym)|uniprotkb:Deubiquitinating enzyme 7(gene name synonym)|uniprotkb:Herpesvirus-associated ubiquitin-specific protease(gene name synonym) psi-mi:tripc_human(display_long)|uniprotkb:TRIP12(gene name)|psi-mi:TRIP12(display_short)|uniprotkb:Thyroid receptor-interacting protein 12(gene name synonym)|uniprotkb:KIAA0045(gene name synonym)|uniprotkb:E3 ubiquitin-protein ligase for Arf(gene name synonym)|uniprotkb:ULF(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase TRIP12(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513133|imex:IM-12079-80 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:4PYZ|rcsb pdb:4WPH|rcsb pdb:4WPI|rcsb pdb:4YOC|rcsb pdb:4YSI|rcsb pdb:4Z96|rcsb pdb:4Z97|rcsb pdb:5C56|rcsb pdb:5C6D|rcsb pdb:5FWI|rcsb pdb:5GG4|rcsb pdb:5J7T|rcsb pdb:5JTJ|rcsb pdb:5JTV|rcsb pdb:5KYB|rcsb pdb:4M5X|rcsb pdb:5KYC|rcsb pdb:5KYD|rcsb pdb:5KYE|rcsb pdb:5KYF|interpro:IPR029346|interpro:IPR038765|mint:Q93009|rcsb pdb:1NB8|rcsb pdb:1NBF|rcsb pdb:1YY6|rcsb pdb:1YZE|rcsb pdb:2F1W|rcsb pdb:2F1X|rcsb pdb:2F1Y|rcsb pdb:2F1Z|rcsb pdb:2FOJ|rcsb pdb:2FOO|rcsb pdb:2FOP|rcsb pdb:2KVR|rcsb pdb:2XXN|rcsb pdb:2YLM|rcsb pdb:3MQR|rcsb pdb:3MQS|rcsb pdb:4JJQ|rcsb pdb:4KG9|rcsb pdb:4M5W|go:"GO:0006283"(transcription-coupled nucleotide-excision repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010216"(maintenance of DNA methylation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035520"(monoubiquitinated protein deubiquitination)|go:"GO:0035616"(histone H2B conserved C-terminal lysine deubiquitination)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0048511"(rhythmic process)|go:"GO:0050821"(protein stabilization)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0101005"(deubiquitinase activity)|go:"GO:1901537"(positive regulation of DNA demethylation)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1904353"(regulation of telomere capping)|go:"GO:1905279"(regulation of retrograde transport, endosome to Golgi)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR018200|interpro:IPR024729|interpro:IPR028889|ensembl:ENSG00000187555(gene)|ensembl:ENST00000344836(transcript)|go:"GO:0002039"(p53 binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0006111"(regulation of gluconeogenesis)|rcsb pdb:5N9R|rcsb pdb:5N9T|rcsb pdb:5NGE|rcsb pdb:5NGF|rcsb pdb:5UQV|rcsb pdb:5UQX|rcsb pdb:5VS6|rcsb pdb:5VSB|rcsb pdb:5VSK|rcsb pdb:5WHC|rcsb pdb:6F5H|rcsb pdb:6M1K|rcsb pdb:6P5L|rcsb pdb:6VN2|rcsb pdb:6VN3|rcsb pdb:6VN4|rcsb pdb:6VN5|rcsb pdb:6VN6|rcsb pdb:7CM2|reactome:R-HSA-5689880|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6804757|reactome:R-HSA-8866652|reactome:R-HSA-8948747|refseq:NP_001273386.1|refseq:NP_003461.2|refseq:NP_001308787.1|ensembl:ENSP00000343535|ensembl:ENST00000381886|ensembl:ENSP00000371310|dip:DIP-29053N refseq:NP_004229.1|refseq:NP_001271143.1|refseq:NP_001271144.1|refseq:NP_001271145.1|ensembl:ENSG00000153827(gene)|ensembl:ENST00000283943(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016607"(nuclear speck)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0046966"(thyroid hormone receptor binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1901315"(negative regulation of histone H2A K63-linked ubiquitination)|go:"GO:2000779"(regulation of double-strand break repair)|go:"GO:2000780"(negative regulation of double-strand break repair)|interpro:IPR000569(HECT)|interpro:IPR004170(WWE)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR035983|interpro:IPR037197|mint:Q14669|reactome:R-HSA-983168|refseq:NP_001335244.1|refseq:NP_001335245.1|ensembl:ENSP00000283943|ensembl:ENST00000389044|ensembl:ENST00000389045|ensembl:ENSP00000373697|ensembl:ENSP00000373696|dip:DIP-58584N psi-mi:"MI:0469"(intact) - caution:This sequence has been withdrawn from Uniprot.|crc64:294A7C063A3332DE figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:V+PXXBRM2zwlGQaeFiyjaQ9yf+A9606 rogid:wzXMKIUEDV4y7YE6PDU+LIPHl7U9606 intact-crc:0247E0A3D2DA0BA0|rigid:YNzZdLlQUWY3+HOVHH44/ctr6C4 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q93009 uniprotkb:B4DN30 intact:EBI-302474|uniprotkb:A6NMY8|intact:EBI-28988230|ensembl:ENSP00000343535|uniprotkb:B7Z815|uniprotkb:H0Y3G8 intact:EBI-2510114 psi-mi:ubp7_human(display_long)|uniprotkb:USP7(gene name)|psi-mi:USP7(display_short)|uniprotkb:HAUSP(gene name synonym)|uniprotkb:Ubiquitin thioesterase 7(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 7(gene name synonym)|uniprotkb:Deubiquitinating enzyme 7(gene name synonym)|uniprotkb:Herpesvirus-associated ubiquitin-specific protease(gene name synonym) psi-mi:b4dn30_human(display_long) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513133|imex:IM-12079-80 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:4PYZ|rcsb pdb:4WPH|rcsb pdb:4WPI|rcsb pdb:4YOC|rcsb pdb:4YSI|rcsb pdb:4Z96|rcsb pdb:4Z97|rcsb pdb:5C56|rcsb pdb:5C6D|rcsb pdb:5FWI|rcsb pdb:5GG4|rcsb pdb:5J7T|rcsb pdb:5JTJ|rcsb pdb:5JTV|rcsb pdb:5KYB|rcsb pdb:4M5X|rcsb pdb:5KYC|rcsb pdb:5KYD|rcsb pdb:5KYE|rcsb pdb:5KYF|interpro:IPR029346|interpro:IPR038765|mint:Q93009|rcsb pdb:1NB8|rcsb pdb:1NBF|rcsb pdb:1YY6|rcsb pdb:1YZE|rcsb pdb:2F1W|rcsb pdb:2F1X|rcsb pdb:2F1Y|rcsb pdb:2F1Z|rcsb pdb:2FOJ|rcsb pdb:2FOO|rcsb pdb:2FOP|rcsb pdb:2KVR|rcsb pdb:2XXN|rcsb pdb:2YLM|rcsb pdb:3MQR|rcsb pdb:3MQS|rcsb pdb:4JJQ|rcsb pdb:4KG9|rcsb pdb:4M5W|go:"GO:0006283"(transcription-coupled nucleotide-excision repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010216"(maintenance of DNA methylation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035520"(monoubiquitinated protein deubiquitination)|go:"GO:0035616"(histone H2B conserved C-terminal lysine deubiquitination)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0048511"(rhythmic process)|go:"GO:0050821"(protein stabilization)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0101005"(deubiquitinase activity)|go:"GO:1901537"(positive regulation of DNA demethylation)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1904353"(regulation of telomere capping)|go:"GO:1905279"(regulation of retrograde transport, endosome to Golgi)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR018200|interpro:IPR024729|interpro:IPR028889|ensembl:ENSG00000187555(gene)|ensembl:ENST00000344836(transcript)|go:"GO:0002039"(p53 binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0006111"(regulation of gluconeogenesis)|rcsb pdb:5N9R|rcsb pdb:5N9T|rcsb pdb:5NGE|rcsb pdb:5NGF|rcsb pdb:5UQV|rcsb pdb:5UQX|rcsb pdb:5VS6|rcsb pdb:5VSB|rcsb pdb:5VSK|rcsb pdb:5WHC|rcsb pdb:6F5H|rcsb pdb:6M1K|rcsb pdb:6P5L|rcsb pdb:6VN2|rcsb pdb:6VN3|rcsb pdb:6VN4|rcsb pdb:6VN5|rcsb pdb:6VN6|rcsb pdb:7CM2|reactome:R-HSA-5689880|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6804757|reactome:R-HSA-8866652|reactome:R-HSA-8948747|refseq:NP_001273386.1|refseq:NP_003461.2|refseq:NP_001308787.1|ensembl:ENSP00000343535|ensembl:ENST00000381886|ensembl:ENSP00000371310|dip:DIP-29053N interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR001680(WD40 repeat)|refseq:NP_001156981.1|interpro:IPR036322 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:V+PXXBRM2zwlGQaeFiyjaQ9yf+A9606 rogid:Mk9d67PQ07hQYLpZ+jTq4hfKRWk9606 intact-crc:0247E0A3D2DA0BA0|rigid:YNzZdLlQUWY3+HOVHH44/ctr6C4 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q93009 uniprotkb:Q9UHB9 intact:EBI-302474|uniprotkb:A6NMY8|intact:EBI-28988230|ensembl:ENSP00000343535|uniprotkb:B7Z815|uniprotkb:H0Y3G8 intact:EBI-1048560|uniprotkb:Q8NCJ4|uniprotkb:Q8WUK2|uniprotkb:B3KUU5|uniprotkb:B3KWY7|uniprotkb:G3V1U4|ensembl:ENSP00000312066 psi-mi:ubp7_human(display_long)|uniprotkb:USP7(gene name)|psi-mi:USP7(display_short)|uniprotkb:HAUSP(gene name synonym)|uniprotkb:Ubiquitin thioesterase 7(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 7(gene name synonym)|uniprotkb:Deubiquitinating enzyme 7(gene name synonym)|uniprotkb:Herpesvirus-associated ubiquitin-specific protease(gene name synonym) psi-mi:srp68_human(display_long)|uniprotkb:SRP68(gene name)|psi-mi:SRP68(display_short)|uniprotkb:Signal recognition particle 68 kDa protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513133|imex:IM-12079-80 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:4PYZ|rcsb pdb:4WPH|rcsb pdb:4WPI|rcsb pdb:4YOC|rcsb pdb:4YSI|rcsb pdb:4Z96|rcsb pdb:4Z97|rcsb pdb:5C56|rcsb pdb:5C6D|rcsb pdb:5FWI|rcsb pdb:5GG4|rcsb pdb:5J7T|rcsb pdb:5JTJ|rcsb pdb:5JTV|rcsb pdb:5KYB|rcsb pdb:4M5X|rcsb pdb:5KYC|rcsb pdb:5KYD|rcsb pdb:5KYE|rcsb pdb:5KYF|interpro:IPR029346|interpro:IPR038765|mint:Q93009|rcsb pdb:1NB8|rcsb pdb:1NBF|rcsb pdb:1YY6|rcsb pdb:1YZE|rcsb pdb:2F1W|rcsb pdb:2F1X|rcsb pdb:2F1Y|rcsb pdb:2F1Z|rcsb pdb:2FOJ|rcsb pdb:2FOO|rcsb pdb:2FOP|rcsb pdb:2KVR|rcsb pdb:2XXN|rcsb pdb:2YLM|rcsb pdb:3MQR|rcsb pdb:3MQS|rcsb pdb:4JJQ|rcsb pdb:4KG9|rcsb pdb:4M5W|go:"GO:0006283"(transcription-coupled nucleotide-excision repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010216"(maintenance of DNA methylation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035520"(monoubiquitinated protein deubiquitination)|go:"GO:0035616"(histone H2B conserved C-terminal lysine deubiquitination)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0048511"(rhythmic process)|go:"GO:0050821"(protein stabilization)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0101005"(deubiquitinase activity)|go:"GO:1901537"(positive regulation of DNA demethylation)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1904353"(regulation of telomere capping)|go:"GO:1905279"(regulation of retrograde transport, endosome to Golgi)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR018200|interpro:IPR024729|interpro:IPR028889|ensembl:ENSG00000187555(gene)|ensembl:ENST00000344836(transcript)|go:"GO:0002039"(p53 binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0006111"(regulation of gluconeogenesis)|rcsb pdb:5N9R|rcsb pdb:5N9T|rcsb pdb:5NGE|rcsb pdb:5NGF|rcsb pdb:5UQV|rcsb pdb:5UQX|rcsb pdb:5VS6|rcsb pdb:5VSB|rcsb pdb:5VSK|rcsb pdb:5WHC|rcsb pdb:6F5H|rcsb pdb:6M1K|rcsb pdb:6P5L|rcsb pdb:6VN2|rcsb pdb:6VN3|rcsb pdb:6VN4|rcsb pdb:6VN5|rcsb pdb:6VN6|rcsb pdb:7CM2|reactome:R-HSA-5689880|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6804757|reactome:R-HSA-8866652|reactome:R-HSA-8948747|refseq:NP_001273386.1|refseq:NP_003461.2|refseq:NP_001308787.1|ensembl:ENSP00000343535|ensembl:ENST00000381886|ensembl:ENSP00000371310|dip:DIP-29053N refseq:NP_001247431.1|refseq:NP_001247432.1|refseq:NP_055045.2|interpro:IPR026258|interpro:IPR034652|interpro:IPR038253|mint:Q9UHB9|rcsb pdb:4P3E|rcsb pdb:4P3F|rcsb pdb:5M72|rcsb pdb:5M73|rcsb pdb:5WRV|rcsb pdb:7NFX|reactome:R-HSA-1799339|ensembl:ENSG00000167881(gene)|ensembl:ENST00000307877(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005047"(signal recognition particle binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005786"(signal recognition particle, endoplasmic reticulum targeting)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005925"(focal adhesion)|go:"GO:0006614"(SRP-dependent cotranslational protein targeting to membrane)|go:"GO:0008312"(7S RNA binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030942"(endoplasmic reticulum signal peptide binding)|go:"GO:0042493"|go:"GO:0048500"(signal recognition particle)|dip:DIP-50905N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:V+PXXBRM2zwlGQaeFiyjaQ9yf+A9606 rogid:8WwEMUV+QzJGJ6G7xufvSibYTSY9606 intact-crc:0247E0A3D2DA0BA0|rigid:YNzZdLlQUWY3+HOVHH44/ctr6C4 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q93009 uniprotkb:O94966 intact:EBI-302474|uniprotkb:A6NMY8|intact:EBI-28988230|ensembl:ENSP00000343535|uniprotkb:B7Z815|uniprotkb:H0Y3G8 intact:EBI-2511895|ensembl:ENSP00000381863|uniprotkb:Q641Q9|uniprotkb:Q86XV9|uniprotkb:Q3KQW4|uniprotkb:A6H8U2|uniprotkb:Q6NZY8|uniprotkb:A5PKX8|uniprotkb:B4DGT3|uniprotkb:E7ETS0|uniprotkb:E9PEG8|uniprotkb:B4DTZ0|uniprotkb:E7EN22 psi-mi:ubp7_human(display_long)|uniprotkb:USP7(gene name)|psi-mi:USP7(display_short)|uniprotkb:HAUSP(gene name synonym)|uniprotkb:Ubiquitin thioesterase 7(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 7(gene name synonym)|uniprotkb:Deubiquitinating enzyme 7(gene name synonym)|uniprotkb:Herpesvirus-associated ubiquitin-specific protease(gene name synonym) psi-mi:ubp19_human(display_long)|uniprotkb:USP19(gene name)|psi-mi:USP19(display_short)|uniprotkb:KIAA0891(gene name synonym)|uniprotkb:ZMYND9(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 19(gene name synonym)|uniprotkb:Deubiquitinating enzyme 19(gene name synonym)|uniprotkb:Zinc finger MYND domain-containing protein 9(gene name synonym)|uniprotkb:Ubiquitin thioesterase 19(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513133|imex:IM-12079-80 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:4PYZ|rcsb pdb:4WPH|rcsb pdb:4WPI|rcsb pdb:4YOC|rcsb pdb:4YSI|rcsb pdb:4Z96|rcsb pdb:4Z97|rcsb pdb:5C56|rcsb pdb:5C6D|rcsb pdb:5FWI|rcsb pdb:5GG4|rcsb pdb:5J7T|rcsb pdb:5JTJ|rcsb pdb:5JTV|rcsb pdb:5KYB|rcsb pdb:4M5X|rcsb pdb:5KYC|rcsb pdb:5KYD|rcsb pdb:5KYE|rcsb pdb:5KYF|interpro:IPR029346|interpro:IPR038765|mint:Q93009|rcsb pdb:1NB8|rcsb pdb:1NBF|rcsb pdb:1YY6|rcsb pdb:1YZE|rcsb pdb:2F1W|rcsb pdb:2F1X|rcsb pdb:2F1Y|rcsb pdb:2F1Z|rcsb pdb:2FOJ|rcsb pdb:2FOO|rcsb pdb:2FOP|rcsb pdb:2KVR|rcsb pdb:2XXN|rcsb pdb:2YLM|rcsb pdb:3MQR|rcsb pdb:3MQS|rcsb pdb:4JJQ|rcsb pdb:4KG9|rcsb pdb:4M5W|go:"GO:0006283"(transcription-coupled nucleotide-excision repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010216"(maintenance of DNA methylation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035520"(monoubiquitinated protein deubiquitination)|go:"GO:0035616"(histone H2B conserved C-terminal lysine deubiquitination)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0048511"(rhythmic process)|go:"GO:0050821"(protein stabilization)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0101005"(deubiquitinase activity)|go:"GO:1901537"(positive regulation of DNA demethylation)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1904353"(regulation of telomere capping)|go:"GO:1905279"(regulation of retrograde transport, endosome to Golgi)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR018200|interpro:IPR024729|interpro:IPR028889|ensembl:ENSG00000187555(gene)|ensembl:ENST00000344836(transcript)|go:"GO:0002039"(p53 binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0006111"(regulation of gluconeogenesis)|rcsb pdb:5N9R|rcsb pdb:5N9T|rcsb pdb:5NGE|rcsb pdb:5NGF|rcsb pdb:5UQV|rcsb pdb:5UQX|rcsb pdb:5VS6|rcsb pdb:5VSB|rcsb pdb:5VSK|rcsb pdb:5WHC|rcsb pdb:6F5H|rcsb pdb:6M1K|rcsb pdb:6P5L|rcsb pdb:6VN2|rcsb pdb:6VN3|rcsb pdb:6VN4|rcsb pdb:6VN5|rcsb pdb:6VN6|rcsb pdb:7CM2|reactome:R-HSA-5689880|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6804757|reactome:R-HSA-8866652|reactome:R-HSA-8948747|refseq:NP_001273386.1|refseq:NP_003461.2|refseq:NP_001308787.1|ensembl:ENSP00000343535|ensembl:ENST00000381886|ensembl:ENSP00000371310|dip:DIP-29053N ensembl:ENSG00000172046(gene)|ensembl:ENST00000398888(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0046872"(metal ion binding)|go:"GO:0048642"(negative regulation of skeletal muscle tissue development)|go:"GO:0050821"(protein stabilization)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0090068"(positive regulation of cell cycle process)|go:"GO:1900037"(regulation of cellular response to hypoxia)|go:"GO:1901799"(negative regulation of proteasomal protein catabolic process)|go:"GO:1904292"(regulation of ERAD pathway)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR002893(Zinc finger, MYND-type)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|mint:O94966|rcsb pdb:1WH0|rcsb pdb:4X3G|rcsb pdb:6K7W|rcsb pdb:6KHV|rcsb pdb:6KQV|reactome:R-HSA-5689880|refseq:NP_001186089.1|refseq:NP_001186090.1|refseq:NP_001186091.1|refseq:NP_006668.1|refseq:XP_005264888.1|refseq:XP_016861115.1|refseq:XP_016861122.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:V+PXXBRM2zwlGQaeFiyjaQ9yf+A9606 rogid:5U3FuLQ44MsWtu7o/3bY7seGC3M9606 intact-crc:0247E0A3D2DA0BA0|rigid:YNzZdLlQUWY3+HOVHH44/ctr6C4 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q93009 uniprotkb:P78406 intact:EBI-302474|uniprotkb:A6NMY8|intact:EBI-28988230|ensembl:ENSP00000343535|uniprotkb:B7Z815|uniprotkb:H0Y3G8 intact:EBI-724495|uniprotkb:O15306|uniprotkb:Q3SYL7|uniprotkb:Q5TCH8|uniprotkb:Q6V708|uniprotkb:Q9H100|uniprotkb:Q9NQM6|ensembl:ENSP00000360286|ensembl:ENSP00000379181|ensembl:ENSP00000379182|uniprotkb:A8K882 psi-mi:ubp7_human(display_long)|uniprotkb:USP7(gene name)|psi-mi:USP7(display_short)|uniprotkb:HAUSP(gene name synonym)|uniprotkb:Ubiquitin thioesterase 7(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 7(gene name synonym)|uniprotkb:Deubiquitinating enzyme 7(gene name synonym)|uniprotkb:Herpesvirus-associated ubiquitin-specific protease(gene name synonym) psi-mi:rae1l_human(display_long)|uniprotkb:mRNA-associated protein mrnp 41(gene name synonym)|uniprotkb:Rae1 protein homolog(gene name synonym)|uniprotkb:RAE1(gene name)|psi-mi:RAE1(display_short)|uniprotkb:MRNP41(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513133|imex:IM-12079-80 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:4PYZ|rcsb pdb:4WPH|rcsb pdb:4WPI|rcsb pdb:4YOC|rcsb pdb:4YSI|rcsb pdb:4Z96|rcsb pdb:4Z97|rcsb pdb:5C56|rcsb pdb:5C6D|rcsb pdb:5FWI|rcsb pdb:5GG4|rcsb pdb:5J7T|rcsb pdb:5JTJ|rcsb pdb:5JTV|rcsb pdb:5KYB|rcsb pdb:4M5X|rcsb pdb:5KYC|rcsb pdb:5KYD|rcsb pdb:5KYE|rcsb pdb:5KYF|interpro:IPR029346|interpro:IPR038765|mint:Q93009|rcsb pdb:1NB8|rcsb pdb:1NBF|rcsb pdb:1YY6|rcsb pdb:1YZE|rcsb pdb:2F1W|rcsb pdb:2F1X|rcsb pdb:2F1Y|rcsb pdb:2F1Z|rcsb pdb:2FOJ|rcsb pdb:2FOO|rcsb pdb:2FOP|rcsb pdb:2KVR|rcsb pdb:2XXN|rcsb pdb:2YLM|rcsb pdb:3MQR|rcsb pdb:3MQS|rcsb pdb:4JJQ|rcsb pdb:4KG9|rcsb pdb:4M5W|go:"GO:0006283"(transcription-coupled nucleotide-excision repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010216"(maintenance of DNA methylation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035520"(monoubiquitinated protein deubiquitination)|go:"GO:0035616"(histone H2B conserved C-terminal lysine deubiquitination)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0048511"(rhythmic process)|go:"GO:0050821"(protein stabilization)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0101005"(deubiquitinase activity)|go:"GO:1901537"(positive regulation of DNA demethylation)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1904353"(regulation of telomere capping)|go:"GO:1905279"(regulation of retrograde transport, endosome to Golgi)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR018200|interpro:IPR024729|interpro:IPR028889|ensembl:ENSG00000187555(gene)|ensembl:ENST00000344836(transcript)|go:"GO:0002039"(p53 binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0006111"(regulation of gluconeogenesis)|rcsb pdb:5N9R|rcsb pdb:5N9T|rcsb pdb:5NGE|rcsb pdb:5NGF|rcsb pdb:5UQV|rcsb pdb:5UQX|rcsb pdb:5VS6|rcsb pdb:5VSB|rcsb pdb:5VSK|rcsb pdb:5WHC|rcsb pdb:6F5H|rcsb pdb:6M1K|rcsb pdb:6P5L|rcsb pdb:6VN2|rcsb pdb:6VN3|rcsb pdb:6VN4|rcsb pdb:6VN5|rcsb pdb:6VN6|rcsb pdb:7CM2|reactome:R-HSA-5689880|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6804757|reactome:R-HSA-8866652|reactome:R-HSA-8948747|refseq:NP_001273386.1|refseq:NP_003461.2|refseq:NP_001308787.1|ensembl:ENSP00000343535|ensembl:ENST00000381886|ensembl:ENSP00000371310|dip:DIP-29053N refseq:NP_001015885.1|refseq:NP_003601.1|ensembl:ENSG00000101146(gene)|ensembl:ENST00000371242(transcript)|ensembl:ENST00000395840(transcript)|ensembl:ENST00000395841(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006405"(RNA export from nucleus)|go:"GO:0006406"(mRNA export from nucleus)|go:"GO:0007049"(cell cycle)|go:"GO:0008017"(microtubule binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0051301"(cell division)|go:"GO:0060236"(regulation of mitotic spindle organization)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0097431"(mitotic spindle pole)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|go:"GO:0000972"(transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery)|interpro:IPR020472|interpro:IPR036322|interpro:IPR037631|mint:P78406|rcsb pdb:3MMY|rcsb pdb:4OWR|reactome:R-HSA-1169408|reactome:R-HSA-159227|reactome:R-HSA-159230|reactome:R-HSA-159231|reactome:R-HSA-159236|reactome:R-HSA-165054|reactome:R-HSA-168271|reactome:R-HSA-168276|reactome:R-HSA-168325|reactome:R-HSA-168333|reactome:R-HSA-170822|reactome:R-HSA-180746|reactome:R-HSA-180910|reactome:R-HSA-191859|reactome:R-HSA-3108214|reactome:R-HSA-3232142|reactome:R-HSA-3301854|reactome:R-HSA-3371453|reactome:R-HSA-4085377|reactome:R-HSA-4551638|reactome:R-HSA-4570464|interpro:IPR019775|reactome:R-HSA-4615885|reactome:R-HSA-5578749|reactome:R-HSA-5619107|reactome:R-HSA-6784531|reactome:R-HSA-9609690|reactome:R-HSA-9610379|refseq:XP_011527390.1|refseq:XP_011527391.1|refseq:XP_005260639.2|dip:DIP-41063N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:V+PXXBRM2zwlGQaeFiyjaQ9yf+A9606 rogid:JK4Y5p3WUcHFXBXyhhqCnDnG49c9606 intact-crc:0247E0A3D2DA0BA0|rigid:YNzZdLlQUWY3+HOVHH44/ctr6C4 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q93009 uniprotkb:Q14527 intact:EBI-302474|uniprotkb:A6NMY8|intact:EBI-28988230|ensembl:ENSP00000343535|uniprotkb:B7Z815|uniprotkb:H0Y3G8 intact:EBI-1045161|uniprotkb:Q14536|uniprotkb:Q16051|uniprotkb:Q7KYJ6|uniprotkb:Q86YA5|uniprotkb:Q92652|uniprotkb:Q96KM9|uniprotkb:D3DNH3|ensembl:ENSP00000308944|ensembl:ENSP00000376644|ensembl:ENSP00000420429 psi-mi:ubp7_human(display_long)|uniprotkb:USP7(gene name)|psi-mi:USP7(display_short)|uniprotkb:HAUSP(gene name synonym)|uniprotkb:Ubiquitin thioesterase 7(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 7(gene name synonym)|uniprotkb:Deubiquitinating enzyme 7(gene name synonym)|uniprotkb:Herpesvirus-associated ubiquitin-specific protease(gene name synonym) psi-mi:hltf_human(display_long)|uniprotkb:SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 3(gene name synonym)|uniprotkb:Sucrose nonfermenting protein 2-like 3(gene name synonym)|uniprotkb:DNA-binding protein/plasminogen activator inhibitor 1 regulator(gene name synonym)|uniprotkb:HIP116(gene name synonym)|uniprotkb:RING finger protein 80(gene name synonym)|uniprotkb:HLTF(gene name)|psi-mi:HLTF(display_short)|uniprotkb:HIP116A(gene name synonym)|uniprotkb:RNF80(gene name synonym)|uniprotkb:SNF2L3(gene name synonym)|uniprotkb:ZBU1(gene name synonym)|uniprotkb:SMARCA3(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase HLTF(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513133|imex:IM-12079-80 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:4PYZ|rcsb pdb:4WPH|rcsb pdb:4WPI|rcsb pdb:4YOC|rcsb pdb:4YSI|rcsb pdb:4Z96|rcsb pdb:4Z97|rcsb pdb:5C56|rcsb pdb:5C6D|rcsb pdb:5FWI|rcsb pdb:5GG4|rcsb pdb:5J7T|rcsb pdb:5JTJ|rcsb pdb:5JTV|rcsb pdb:5KYB|rcsb pdb:4M5X|rcsb pdb:5KYC|rcsb pdb:5KYD|rcsb pdb:5KYE|rcsb pdb:5KYF|interpro:IPR029346|interpro:IPR038765|mint:Q93009|rcsb pdb:1NB8|rcsb pdb:1NBF|rcsb pdb:1YY6|rcsb pdb:1YZE|rcsb pdb:2F1W|rcsb pdb:2F1X|rcsb pdb:2F1Y|rcsb pdb:2F1Z|rcsb pdb:2FOJ|rcsb pdb:2FOO|rcsb pdb:2FOP|rcsb pdb:2KVR|rcsb pdb:2XXN|rcsb pdb:2YLM|rcsb pdb:3MQR|rcsb pdb:3MQS|rcsb pdb:4JJQ|rcsb pdb:4KG9|rcsb pdb:4M5W|go:"GO:0006283"(transcription-coupled nucleotide-excision repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010216"(maintenance of DNA methylation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035520"(monoubiquitinated protein deubiquitination)|go:"GO:0035616"(histone H2B conserved C-terminal lysine deubiquitination)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0048511"(rhythmic process)|go:"GO:0050821"(protein stabilization)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0101005"(deubiquitinase activity)|go:"GO:1901537"(positive regulation of DNA demethylation)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1904353"(regulation of telomere capping)|go:"GO:1905279"(regulation of retrograde transport, endosome to Golgi)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR018200|interpro:IPR024729|interpro:IPR028889|ensembl:ENSG00000187555(gene)|ensembl:ENST00000344836(transcript)|go:"GO:0002039"(p53 binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0006111"(regulation of gluconeogenesis)|rcsb pdb:5N9R|rcsb pdb:5N9T|rcsb pdb:5NGE|rcsb pdb:5NGF|rcsb pdb:5UQV|rcsb pdb:5UQX|rcsb pdb:5VS6|rcsb pdb:5VSB|rcsb pdb:5VSK|rcsb pdb:5WHC|rcsb pdb:6F5H|rcsb pdb:6M1K|rcsb pdb:6P5L|rcsb pdb:6VN2|rcsb pdb:6VN3|rcsb pdb:6VN4|rcsb pdb:6VN5|rcsb pdb:6VN6|rcsb pdb:7CM2|reactome:R-HSA-5689880|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6804757|reactome:R-HSA-8866652|reactome:R-HSA-8948747|refseq:NP_001273386.1|refseq:NP_003461.2|refseq:NP_001308787.1|ensembl:ENSP00000343535|ensembl:ENST00000381886|ensembl:ENSP00000371310|dip:DIP-29053N refseq:NP_001305863.1|refseq:NP_001305864.1|refseq:NP_003062.2|refseq:NP_620636.1|refseq:XP_016862568.1|dip:DIP-29828N|ensembl:ENSG00000071794(gene)|ensembl:ENST00000310053(transcript)|ensembl:ENST00000392912(transcript)|ensembl:ENST00000494055(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006325"(chromatin organization)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016818"(hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070615"|interpro:IPR000330(SNF2-related)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014905(HIRAN)|interpro:IPR017907|interpro:IPR027417|interpro:IPR038718|mint:Q14527|rcsb pdb:2MZN|rcsb pdb:4HRE|rcsb pdb:4HRH|rcsb pdb:4S0N|rcsb pdb:4XZF|rcsb pdb:4XZG|rcsb pdb:5BNH|rcsb pdb:5K5F|rcsb pdb:6KCS|reactome:R-HSA-8866654 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:V+PXXBRM2zwlGQaeFiyjaQ9yf+A9606 rogid:ozxGwYPSrDJ+Fg3F64VfE0Bc0wM9606 intact-crc:0247E0A3D2DA0BA0|rigid:YNzZdLlQUWY3+HOVHH44/ctr6C4 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q93009 uniprotkb:P46736 intact:EBI-302474|uniprotkb:A6NMY8|intact:EBI-28988230|ensembl:ENSP00000343535|uniprotkb:B7Z815|uniprotkb:H0Y3G8 intact:EBI-750352|uniprotkb:Q16107|uniprotkb:Q9BTZ6|uniprotkb:A6QRF8|uniprotkb:A6QRF9|uniprotkb:A8MUX5|uniprotkb:A8MWH0|uniprotkb:A9Z1Y0|uniprotkb:A9Z1Y5|uniprotkb:B1B062|uniprotkb:B4DQN7|uniprotkb:Q53YX5|ensembl:ENSP00000358474 psi-mi:ubp7_human(display_long)|uniprotkb:USP7(gene name)|psi-mi:USP7(display_short)|uniprotkb:HAUSP(gene name synonym)|uniprotkb:Ubiquitin thioesterase 7(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 7(gene name synonym)|uniprotkb:Deubiquitinating enzyme 7(gene name synonym)|uniprotkb:Herpesvirus-associated ubiquitin-specific protease(gene name synonym) psi-mi:brcc3_human(display_long)|uniprotkb:BRCC3(gene name)|psi-mi:BRCC3(display_short)|uniprotkb:C6.1A(gene name synonym)|uniprotkb:CXorf53(gene name synonym)|uniprotkb:BRCC36(gene name synonym)|uniprotkb:BRCA1-A complex subunit BRCC36(gene name synonym)|uniprotkb:BRISC complex subunit BRCC36(gene name synonym)|uniprotkb:BRCA1/BRCA2-containing complex subunit 3(gene name synonym)|uniprotkb:BRCA1/BRCA2-containing complex subunit 36(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513133|imex:IM-12079-80 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:4PYZ|rcsb pdb:4WPH|rcsb pdb:4WPI|rcsb pdb:4YOC|rcsb pdb:4YSI|rcsb pdb:4Z96|rcsb pdb:4Z97|rcsb pdb:5C56|rcsb pdb:5C6D|rcsb pdb:5FWI|rcsb pdb:5GG4|rcsb pdb:5J7T|rcsb pdb:5JTJ|rcsb pdb:5JTV|rcsb pdb:5KYB|rcsb pdb:4M5X|rcsb pdb:5KYC|rcsb pdb:5KYD|rcsb pdb:5KYE|rcsb pdb:5KYF|interpro:IPR029346|interpro:IPR038765|mint:Q93009|rcsb pdb:1NB8|rcsb pdb:1NBF|rcsb pdb:1YY6|rcsb pdb:1YZE|rcsb pdb:2F1W|rcsb pdb:2F1X|rcsb pdb:2F1Y|rcsb pdb:2F1Z|rcsb pdb:2FOJ|rcsb pdb:2FOO|rcsb pdb:2FOP|rcsb pdb:2KVR|rcsb pdb:2XXN|rcsb pdb:2YLM|rcsb pdb:3MQR|rcsb pdb:3MQS|rcsb pdb:4JJQ|rcsb pdb:4KG9|rcsb pdb:4M5W|go:"GO:0006283"(transcription-coupled nucleotide-excision repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010216"(maintenance of DNA methylation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035520"(monoubiquitinated protein deubiquitination)|go:"GO:0035616"(histone H2B conserved C-terminal lysine deubiquitination)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0048511"(rhythmic process)|go:"GO:0050821"(protein stabilization)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0101005"(deubiquitinase activity)|go:"GO:1901537"(positive regulation of DNA demethylation)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1904353"(regulation of telomere capping)|go:"GO:1905279"(regulation of retrograde transport, endosome to Golgi)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR018200|interpro:IPR024729|interpro:IPR028889|ensembl:ENSG00000187555(gene)|ensembl:ENST00000344836(transcript)|go:"GO:0002039"(p53 binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0006111"(regulation of gluconeogenesis)|rcsb pdb:5N9R|rcsb pdb:5N9T|rcsb pdb:5NGE|rcsb pdb:5NGF|rcsb pdb:5UQV|rcsb pdb:5UQX|rcsb pdb:5VS6|rcsb pdb:5VSB|rcsb pdb:5VSK|rcsb pdb:5WHC|rcsb pdb:6F5H|rcsb pdb:6M1K|rcsb pdb:6P5L|rcsb pdb:6VN2|rcsb pdb:6VN3|rcsb pdb:6VN4|rcsb pdb:6VN5|rcsb pdb:6VN6|rcsb pdb:7CM2|reactome:R-HSA-5689880|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6804757|reactome:R-HSA-8866652|reactome:R-HSA-8948747|refseq:NP_001273386.1|refseq:NP_003461.2|refseq:NP_001308787.1|ensembl:ENSP00000343535|ensembl:ENST00000381886|ensembl:ENSP00000371310|dip:DIP-29053N refseq:NP_001018065.1|refseq:NP_001229569.1|refseq:NP_077308.1|refseq:XP_016885327.1|dip:DIP-48719N|ensembl:ENSG00000185515(gene)|go:"GO:0000152"(nuclear ubiquitin ligase complex)|go:"GO:0000922"(spindle pole)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0010165"(response to X-ray)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0046872"(metal ion binding)|go:"GO:0051301"(cell division)|go:"GO:0061578"(Lys63-specific deubiquitinase activity)|go:"GO:0070122"(isopeptidase activity)|ensembl:ENST00000369462(transcript)|go:"GO:0070531"(BRCA1-A complex)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0070537"(histone H2A K63-linked deubiquitination)|go:"GO:0070552"(BRISC complex)|go:"GO:0000151"(ubiquitin ligase complex)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR033860|interpro:IPR037518|interpro:IPR040749|mint:P46736|rcsb pdb:6H3C|rcsb pdb:6R8F|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473 psi-mi:"MI:0469"(intact) - caution:This sequence has been withdrawn from Uniprot.|crc64:5720358C1A2F7421 figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:V+PXXBRM2zwlGQaeFiyjaQ9yf+A9606 rogid:4YP0TYSnZOZQ4mFEmr07XIx+AVw9606 intact-crc:0247E0A3D2DA0BA0|rigid:YNzZdLlQUWY3+HOVHH44/ctr6C4 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q93009 uniprotkb:Q96N67 intact:EBI-302474|uniprotkb:A6NMY8|intact:EBI-28988230|ensembl:ENSP00000343535|uniprotkb:B7Z815|uniprotkb:H0Y3G8 intact:EBI-2433703|uniprotkb:Q00M63|uniprotkb:Q2PPY7|uniprotkb:Q45RE8|uniprotkb:Q45RE9|uniprotkb:Q5T1B9|uniprotkb:Q5T1C0|uniprotkb:Q6ZV32|uniprotkb:Q8TB82|uniprotkb:Q96NG6|uniprotkb:Q9C092|intact:EBI-7303260|intact:MINT-1683616|uniprotkb:Q96NI0|intact:EBI-28980506|ensembl:ENSP00000489124 psi-mi:ubp7_human(display_long)|uniprotkb:USP7(gene name)|psi-mi:USP7(display_short)|uniprotkb:HAUSP(gene name synonym)|uniprotkb:Ubiquitin thioesterase 7(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 7(gene name synonym)|uniprotkb:Deubiquitinating enzyme 7(gene name synonym)|uniprotkb:Herpesvirus-associated ubiquitin-specific protease(gene name synonym) psi-mi:dock7_human(display_long)|uniprotkb:DOCK7(gene name)|psi-mi:DOCK7(display_short)|uniprotkb:KIAA1771(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513133|imex:IM-12079-80 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:4PYZ|rcsb pdb:4WPH|rcsb pdb:4WPI|rcsb pdb:4YOC|rcsb pdb:4YSI|rcsb pdb:4Z96|rcsb pdb:4Z97|rcsb pdb:5C56|rcsb pdb:5C6D|rcsb pdb:5FWI|rcsb pdb:5GG4|rcsb pdb:5J7T|rcsb pdb:5JTJ|rcsb pdb:5JTV|rcsb pdb:5KYB|rcsb pdb:4M5X|rcsb pdb:5KYC|rcsb pdb:5KYD|rcsb pdb:5KYE|rcsb pdb:5KYF|interpro:IPR029346|interpro:IPR038765|mint:Q93009|rcsb pdb:1NB8|rcsb pdb:1NBF|rcsb pdb:1YY6|rcsb pdb:1YZE|rcsb pdb:2F1W|rcsb pdb:2F1X|rcsb pdb:2F1Y|rcsb pdb:2F1Z|rcsb pdb:2FOJ|rcsb pdb:2FOO|rcsb pdb:2FOP|rcsb pdb:2KVR|rcsb pdb:2XXN|rcsb pdb:2YLM|rcsb pdb:3MQR|rcsb pdb:3MQS|rcsb pdb:4JJQ|rcsb pdb:4KG9|rcsb pdb:4M5W|go:"GO:0006283"(transcription-coupled nucleotide-excision repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010216"(maintenance of DNA methylation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035520"(monoubiquitinated protein deubiquitination)|go:"GO:0035616"(histone H2B conserved C-terminal lysine deubiquitination)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0048511"(rhythmic process)|go:"GO:0050821"(protein stabilization)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0101005"(deubiquitinase activity)|go:"GO:1901537"(positive regulation of DNA demethylation)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1904353"(regulation of telomere capping)|go:"GO:1905279"(regulation of retrograde transport, endosome to Golgi)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR018200|interpro:IPR024729|interpro:IPR028889|ensembl:ENSG00000187555(gene)|ensembl:ENST00000344836(transcript)|go:"GO:0002039"(p53 binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0006111"(regulation of gluconeogenesis)|rcsb pdb:5N9R|rcsb pdb:5N9T|rcsb pdb:5NGE|rcsb pdb:5NGF|rcsb pdb:5UQV|rcsb pdb:5UQX|rcsb pdb:5VS6|rcsb pdb:5VSB|rcsb pdb:5VSK|rcsb pdb:5WHC|rcsb pdb:6F5H|rcsb pdb:6M1K|rcsb pdb:6P5L|rcsb pdb:6VN2|rcsb pdb:6VN3|rcsb pdb:6VN4|rcsb pdb:6VN5|rcsb pdb:6VN6|rcsb pdb:7CM2|reactome:R-HSA-5689880|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6804757|reactome:R-HSA-8866652|reactome:R-HSA-8948747|refseq:NP_001273386.1|refseq:NP_003461.2|refseq:NP_001308787.1|ensembl:ENSP00000343535|ensembl:ENST00000381886|ensembl:ENSP00000371310|dip:DIP-29053N refseq:XP_011540628.1|refseq:NP_001258931.1|refseq:NP_212132.2|ensembl:ENST00000251157|ensembl:ENSP00000251157|ensembl:ENST00000340370|ensembl:ENSP00000340742|ensembl:ENST00000404627|ensembl:ENSP00000384446|ensembl:ENST00000454575|ensembl:ENSP00000413583|ensembl:ENST00000634264|ensembl:ENSP00000489284|ensembl:ENST00000635123|ensembl:ENSP00000489499|ensembl:ENSP00000489124|refseq:NP_001258928.1|refseq:NP_001258929.1|refseq:NP_001258930.1|refseq:NP_001317543.1|ensembl:ENSG00000116641(gene)|ensembl:ENST00000635253(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005925"(focal adhesion)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0007409"(axonogenesis)|go:"GO:0022027"(interkinetic nuclear migration)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0031175"(neuron projection development)|go:"GO:0031267"(small GTPase binding)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0043005"(neuron projection)|go:"GO:0045178"(basal part of cell)|go:"GO:0045200"(establishment of neuroblast polarity)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|interpro:IPR010703(Dedicator of cytokinesis)|interpro:IPR021816|interpro:IPR026791|interpro:IPR027007|interpro:IPR027357|interpro:IPR035892|interpro:IPR037808|interpro:IPR043161|interpro:IPR043162|mint:Q96N67|rcsb pdb:6AJ4|rcsb pdb:6AJL|reactome:R-HSA-8875555|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-983231 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:V+PXXBRM2zwlGQaeFiyjaQ9yf+A9606 rogid:PHjIS0j8JJ6Il3knhzjCzMNkxKk9606 intact-crc:0247E0A3D2DA0BA0|rigid:YNzZdLlQUWY3+HOVHH44/ctr6C4 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q93009 uniprotkb:Q9UQR0 intact:EBI-302474|uniprotkb:A6NMY8|intact:EBI-28988230|ensembl:ENSP00000343535|uniprotkb:B7Z815|uniprotkb:H0Y3G8 intact:EBI-2513111|ensembl:ENSP00000251900|uniprotkb:Q8IWD0|uniprotkb:Q86U98|uniprotkb:Q8NDP2|uniprotkb:Q9UGC5|uniprotkb:Q5JXE6 psi-mi:ubp7_human(display_long)|uniprotkb:USP7(gene name)|psi-mi:USP7(display_short)|uniprotkb:HAUSP(gene name synonym)|uniprotkb:Ubiquitin thioesterase 7(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 7(gene name synonym)|uniprotkb:Deubiquitinating enzyme 7(gene name synonym)|uniprotkb:Herpesvirus-associated ubiquitin-specific protease(gene name synonym) psi-mi:scml2_human(display_long)|uniprotkb:SCML2(gene name)|psi-mi:SCML2(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513133|imex:IM-12079-80 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:4PYZ|rcsb pdb:4WPH|rcsb pdb:4WPI|rcsb pdb:4YOC|rcsb pdb:4YSI|rcsb pdb:4Z96|rcsb pdb:4Z97|rcsb pdb:5C56|rcsb pdb:5C6D|rcsb pdb:5FWI|rcsb pdb:5GG4|rcsb pdb:5J7T|rcsb pdb:5JTJ|rcsb pdb:5JTV|rcsb pdb:5KYB|rcsb pdb:4M5X|rcsb pdb:5KYC|rcsb pdb:5KYD|rcsb pdb:5KYE|rcsb pdb:5KYF|interpro:IPR029346|interpro:IPR038765|mint:Q93009|rcsb pdb:1NB8|rcsb pdb:1NBF|rcsb pdb:1YY6|rcsb pdb:1YZE|rcsb pdb:2F1W|rcsb pdb:2F1X|rcsb pdb:2F1Y|rcsb pdb:2F1Z|rcsb pdb:2FOJ|rcsb pdb:2FOO|rcsb pdb:2FOP|rcsb pdb:2KVR|rcsb pdb:2XXN|rcsb pdb:2YLM|rcsb pdb:3MQR|rcsb pdb:3MQS|rcsb pdb:4JJQ|rcsb pdb:4KG9|rcsb pdb:4M5W|go:"GO:0006283"(transcription-coupled nucleotide-excision repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010216"(maintenance of DNA methylation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035520"(monoubiquitinated protein deubiquitination)|go:"GO:0035616"(histone H2B conserved C-terminal lysine deubiquitination)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0048511"(rhythmic process)|go:"GO:0050821"(protein stabilization)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0101005"(deubiquitinase activity)|go:"GO:1901537"(positive regulation of DNA demethylation)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1904353"(regulation of telomere capping)|go:"GO:1905279"(regulation of retrograde transport, endosome to Golgi)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR018200|interpro:IPR024729|interpro:IPR028889|ensembl:ENSG00000187555(gene)|ensembl:ENST00000344836(transcript)|go:"GO:0002039"(p53 binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0006111"(regulation of gluconeogenesis)|rcsb pdb:5N9R|rcsb pdb:5N9T|rcsb pdb:5NGE|rcsb pdb:5NGF|rcsb pdb:5UQV|rcsb pdb:5UQX|rcsb pdb:5VS6|rcsb pdb:5VSB|rcsb pdb:5VSK|rcsb pdb:5WHC|rcsb pdb:6F5H|rcsb pdb:6M1K|rcsb pdb:6P5L|rcsb pdb:6VN2|rcsb pdb:6VN3|rcsb pdb:6VN4|rcsb pdb:6VN5|rcsb pdb:6VN6|rcsb pdb:7CM2|reactome:R-HSA-5689880|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6804757|reactome:R-HSA-8866652|reactome:R-HSA-8948747|refseq:NP_001273386.1|refseq:NP_003461.2|refseq:NP_001308787.1|ensembl:ENSP00000343535|ensembl:ENST00000381886|ensembl:ENSP00000371310|dip:DIP-29053N ensembl:ENSG00000102098(gene)|ensembl:ENST00000251900(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0031519"(PcG protein complex)|go:"GO:0042393"(histone binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR004092(Mbt repeat)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR021987|interpro:IPR033763|interpro:IPR038348|mint:Q9UQR0|rcsb pdb:1OI1|rcsb pdb:2BIV|rcsb pdb:2MEM|rcsb pdb:2VYT|rcsb pdb:4EDU|refseq:NP_006080.1|refseq:XP_016884708.1|refseq:XP_016884709.1|dip:DIP-53760N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:V+PXXBRM2zwlGQaeFiyjaQ9yf+A9606 rogid:6nmElZ2VXM/O5RZx+i1iu9JnsK09606 intact-crc:0247E0A3D2DA0BA0|rigid:YNzZdLlQUWY3+HOVHH44/ctr6C4 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q93009 uniprotkb:Q16204 intact:EBI-302474|uniprotkb:A6NMY8|intact:EBI-28988230|ensembl:ENSP00000343535|uniprotkb:B7Z815|uniprotkb:H0Y3G8 intact:EBI-1045350|uniprotkb:Q15250|uniprotkb:Q6GSG7|ensembl:ENSP00000263102 psi-mi:ubp7_human(display_long)|uniprotkb:USP7(gene name)|psi-mi:USP7(display_short)|uniprotkb:HAUSP(gene name synonym)|uniprotkb:Ubiquitin thioesterase 7(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 7(gene name synonym)|uniprotkb:Deubiquitinating enzyme 7(gene name synonym)|uniprotkb:Herpesvirus-associated ubiquitin-specific protease(gene name synonym) psi-mi:ccdc6_human(display_long)|uniprotkb:Protein H4(gene name synonym)|uniprotkb:Papillary thyroid carcinoma-encoded protein(gene name synonym)|uniprotkb:CCDC6(gene name)|psi-mi:CCDC6(display_short)|uniprotkb:D10S170(gene name synonym)|uniprotkb:TST1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513133|imex:IM-12079-80 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:4PYZ|rcsb pdb:4WPH|rcsb pdb:4WPI|rcsb pdb:4YOC|rcsb pdb:4YSI|rcsb pdb:4Z96|rcsb pdb:4Z97|rcsb pdb:5C56|rcsb pdb:5C6D|rcsb pdb:5FWI|rcsb pdb:5GG4|rcsb pdb:5J7T|rcsb pdb:5JTJ|rcsb pdb:5JTV|rcsb pdb:5KYB|rcsb pdb:4M5X|rcsb pdb:5KYC|rcsb pdb:5KYD|rcsb pdb:5KYE|rcsb pdb:5KYF|interpro:IPR029346|interpro:IPR038765|mint:Q93009|rcsb pdb:1NB8|rcsb pdb:1NBF|rcsb pdb:1YY6|rcsb pdb:1YZE|rcsb pdb:2F1W|rcsb pdb:2F1X|rcsb pdb:2F1Y|rcsb pdb:2F1Z|rcsb pdb:2FOJ|rcsb pdb:2FOO|rcsb pdb:2FOP|rcsb pdb:2KVR|rcsb pdb:2XXN|rcsb pdb:2YLM|rcsb pdb:3MQR|rcsb pdb:3MQS|rcsb pdb:4JJQ|rcsb pdb:4KG9|rcsb pdb:4M5W|go:"GO:0006283"(transcription-coupled nucleotide-excision repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010216"(maintenance of DNA methylation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035520"(monoubiquitinated protein deubiquitination)|go:"GO:0035616"(histone H2B conserved C-terminal lysine deubiquitination)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0048511"(rhythmic process)|go:"GO:0050821"(protein stabilization)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0101005"(deubiquitinase activity)|go:"GO:1901537"(positive regulation of DNA demethylation)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1904353"(regulation of telomere capping)|go:"GO:1905279"(regulation of retrograde transport, endosome to Golgi)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR018200|interpro:IPR024729|interpro:IPR028889|ensembl:ENSG00000187555(gene)|ensembl:ENST00000344836(transcript)|go:"GO:0002039"(p53 binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0006111"(regulation of gluconeogenesis)|rcsb pdb:5N9R|rcsb pdb:5N9T|rcsb pdb:5NGE|rcsb pdb:5NGF|rcsb pdb:5UQV|rcsb pdb:5UQX|rcsb pdb:5VS6|rcsb pdb:5VSB|rcsb pdb:5VSK|rcsb pdb:5WHC|rcsb pdb:6F5H|rcsb pdb:6M1K|rcsb pdb:6P5L|rcsb pdb:6VN2|rcsb pdb:6VN3|rcsb pdb:6VN4|rcsb pdb:6VN5|rcsb pdb:6VN6|rcsb pdb:7CM2|reactome:R-HSA-5689880|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6804757|reactome:R-HSA-8866652|reactome:R-HSA-8948747|refseq:NP_001273386.1|refseq:NP_003461.2|refseq:NP_001308787.1|ensembl:ENSP00000343535|ensembl:ENST00000381886|ensembl:ENSP00000371310|dip:DIP-29053N refseq:NP_005427.2|ensembl:ENSG00000108091(gene)|ensembl:ENST00000263102(transcript)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0042802"(identical protein binding)|interpro:IPR019152 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:V+PXXBRM2zwlGQaeFiyjaQ9yf+A9606 rogid:nPX3jyRnTSavY0tKyxDiVo35n8E9606 intact-crc:0247E0A3D2DA0BA0|rigid:YNzZdLlQUWY3+HOVHH44/ctr6C4 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q93009 uniprotkb:Q9NWV8 intact:EBI-302474|uniprotkb:A6NMY8|intact:EBI-28988230|ensembl:ENSP00000343535|uniprotkb:B7Z815|uniprotkb:H0Y3G8 intact:EBI-745725|uniprotkb:Q6FIA0|uniprotkb:Q9P018|uniprotkb:A8MQT0|uniprotkb:B4DRY9|uniprotkb:B4DVR1|ensembl:ENSP00000352408|ensembl:ENSP00000470920|ensembl:ENSP00000471605 psi-mi:ubp7_human(display_long)|uniprotkb:USP7(gene name)|psi-mi:USP7(display_short)|uniprotkb:HAUSP(gene name synonym)|uniprotkb:Ubiquitin thioesterase 7(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 7(gene name synonym)|uniprotkb:Deubiquitinating enzyme 7(gene name synonym)|uniprotkb:Herpesvirus-associated ubiquitin-specific protease(gene name synonym) psi-mi:baba1_human(display_long)|uniprotkb:BABAM1(gene name)|psi-mi:BABAM1(display_short)|uniprotkb:HSPC142(orf name)|uniprotkb:C19orf62(gene name synonym)|uniprotkb:NBA1(gene name synonym)|uniprotkb:Mediator of RAP80 interactions and targeting subunit of 40 kDa(gene name synonym)|uniprotkb:New component of the BRCA1-A complex(gene name synonym)|uniprotkb:MERIT40(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513133|imex:IM-12079-80 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:4PYZ|rcsb pdb:4WPH|rcsb pdb:4WPI|rcsb pdb:4YOC|rcsb pdb:4YSI|rcsb pdb:4Z96|rcsb pdb:4Z97|rcsb pdb:5C56|rcsb pdb:5C6D|rcsb pdb:5FWI|rcsb pdb:5GG4|rcsb pdb:5J7T|rcsb pdb:5JTJ|rcsb pdb:5JTV|rcsb pdb:5KYB|rcsb pdb:4M5X|rcsb pdb:5KYC|rcsb pdb:5KYD|rcsb pdb:5KYE|rcsb pdb:5KYF|interpro:IPR029346|interpro:IPR038765|mint:Q93009|rcsb pdb:1NB8|rcsb pdb:1NBF|rcsb pdb:1YY6|rcsb pdb:1YZE|rcsb pdb:2F1W|rcsb pdb:2F1X|rcsb pdb:2F1Y|rcsb pdb:2F1Z|rcsb pdb:2FOJ|rcsb pdb:2FOO|rcsb pdb:2FOP|rcsb pdb:2KVR|rcsb pdb:2XXN|rcsb pdb:2YLM|rcsb pdb:3MQR|rcsb pdb:3MQS|rcsb pdb:4JJQ|rcsb pdb:4KG9|rcsb pdb:4M5W|go:"GO:0006283"(transcription-coupled nucleotide-excision repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010216"(maintenance of DNA methylation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035520"(monoubiquitinated protein deubiquitination)|go:"GO:0035616"(histone H2B conserved C-terminal lysine deubiquitination)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0048511"(rhythmic process)|go:"GO:0050821"(protein stabilization)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0101005"(deubiquitinase activity)|go:"GO:1901537"(positive regulation of DNA demethylation)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1904353"(regulation of telomere capping)|go:"GO:1905279"(regulation of retrograde transport, endosome to Golgi)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR018200|interpro:IPR024729|interpro:IPR028889|ensembl:ENSG00000187555(gene)|ensembl:ENST00000344836(transcript)|go:"GO:0002039"(p53 binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0006111"(regulation of gluconeogenesis)|rcsb pdb:5N9R|rcsb pdb:5N9T|rcsb pdb:5NGE|rcsb pdb:5NGF|rcsb pdb:5UQV|rcsb pdb:5UQX|rcsb pdb:5VS6|rcsb pdb:5VSB|rcsb pdb:5VSK|rcsb pdb:5WHC|rcsb pdb:6F5H|rcsb pdb:6M1K|rcsb pdb:6P5L|rcsb pdb:6VN2|rcsb pdb:6VN3|rcsb pdb:6VN4|rcsb pdb:6VN5|rcsb pdb:6VN6|rcsb pdb:7CM2|reactome:R-HSA-5689880|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6804757|reactome:R-HSA-8866652|reactome:R-HSA-8948747|refseq:NP_001273386.1|refseq:NP_003461.2|refseq:NP_001308787.1|ensembl:ENSP00000343535|ensembl:ENST00000381886|ensembl:ENSP00000371310|dip:DIP-29053N refseq:NP_001028721.1|refseq:NP_054892.2|ensembl:ENSG00000105393(gene)|ensembl:ENST00000359435(transcript)|ensembl:ENST00000598188(transcript)|ensembl:ENST00000601043(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006325"(chromatin organization)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016604"(nuclear body)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0051301"(cell division)|go:"GO:0070531"(BRCA1-A complex)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0070552"(BRISC complex)|interpro:IPR026126|interpro:IPR036465|mint:Q9NWV8|rcsb pdb:6H3C|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473|refseq:NP_001275685.1|refseq:NP_001275686.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:V+PXXBRM2zwlGQaeFiyjaQ9yf+A9606 rogid:o71OvjzuL/7w4247ap7fm6i3pXU9606 intact-crc:0247E0A3D2DA0BA0|rigid:YNzZdLlQUWY3+HOVHH44/ctr6C4 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q93009 uniprotkb:Q14566 intact:EBI-302474|uniprotkb:A6NMY8|intact:EBI-28988230|ensembl:ENSP00000343535|uniprotkb:B7Z815|uniprotkb:H0Y3G8 intact:EBI-374900|uniprotkb:Q13504|uniprotkb:Q99859|uniprotkb:B2R6H2|ensembl:ENSP00000264156 psi-mi:ubp7_human(display_long)|uniprotkb:USP7(gene name)|psi-mi:USP7(display_short)|uniprotkb:HAUSP(gene name synonym)|uniprotkb:Ubiquitin thioesterase 7(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 7(gene name synonym)|uniprotkb:Deubiquitinating enzyme 7(gene name synonym)|uniprotkb:Herpesvirus-associated ubiquitin-specific protease(gene name synonym) psi-mi:mcm6_human(display_long)|uniprotkb:MCM6(gene name)|psi-mi:MCM6(display_short)|uniprotkb:p105MCM(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513133|imex:IM-12079-80 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:4PYZ|rcsb pdb:4WPH|rcsb pdb:4WPI|rcsb pdb:4YOC|rcsb pdb:4YSI|rcsb pdb:4Z96|rcsb pdb:4Z97|rcsb pdb:5C56|rcsb pdb:5C6D|rcsb pdb:5FWI|rcsb pdb:5GG4|rcsb pdb:5J7T|rcsb pdb:5JTJ|rcsb pdb:5JTV|rcsb pdb:5KYB|rcsb pdb:4M5X|rcsb pdb:5KYC|rcsb pdb:5KYD|rcsb pdb:5KYE|rcsb pdb:5KYF|interpro:IPR029346|interpro:IPR038765|mint:Q93009|rcsb pdb:1NB8|rcsb pdb:1NBF|rcsb pdb:1YY6|rcsb pdb:1YZE|rcsb pdb:2F1W|rcsb pdb:2F1X|rcsb pdb:2F1Y|rcsb pdb:2F1Z|rcsb pdb:2FOJ|rcsb pdb:2FOO|rcsb pdb:2FOP|rcsb pdb:2KVR|rcsb pdb:2XXN|rcsb pdb:2YLM|rcsb pdb:3MQR|rcsb pdb:3MQS|rcsb pdb:4JJQ|rcsb pdb:4KG9|rcsb pdb:4M5W|go:"GO:0006283"(transcription-coupled nucleotide-excision repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010216"(maintenance of DNA methylation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035520"(monoubiquitinated protein deubiquitination)|go:"GO:0035616"(histone H2B conserved C-terminal lysine deubiquitination)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0048511"(rhythmic process)|go:"GO:0050821"(protein stabilization)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0101005"(deubiquitinase activity)|go:"GO:1901537"(positive regulation of DNA demethylation)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1904353"(regulation of telomere capping)|go:"GO:1905279"(regulation of retrograde transport, endosome to Golgi)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR018200|interpro:IPR024729|interpro:IPR028889|ensembl:ENSG00000187555(gene)|ensembl:ENST00000344836(transcript)|go:"GO:0002039"(p53 binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0006111"(regulation of gluconeogenesis)|rcsb pdb:5N9R|rcsb pdb:5N9T|rcsb pdb:5NGE|rcsb pdb:5NGF|rcsb pdb:5UQV|rcsb pdb:5UQX|rcsb pdb:5VS6|rcsb pdb:5VSB|rcsb pdb:5VSK|rcsb pdb:5WHC|rcsb pdb:6F5H|rcsb pdb:6M1K|rcsb pdb:6P5L|rcsb pdb:6VN2|rcsb pdb:6VN3|rcsb pdb:6VN4|rcsb pdb:6VN5|rcsb pdb:6VN6|rcsb pdb:7CM2|reactome:R-HSA-5689880|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6804757|reactome:R-HSA-8866652|reactome:R-HSA-8948747|refseq:NP_001273386.1|refseq:NP_003461.2|refseq:NP_001308787.1|ensembl:ENSP00000343535|ensembl:ENST00000381886|ensembl:ENSP00000371310|dip:DIP-29053N ensembl:ENST00000264156(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0042555"(MCM complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0071162"(CMG complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902969"(mitotic DNA replication)|ensembl:ENSG00000076003(gene)|reactome:R-HSA-68962|reactome:R-HSA-69052|interpro:IPR008049(MCM protein 6)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR018525|interpro:IPR027417|interpro:IPR027925|interpro:IPR031327|interpro:IPR033762|interpro:IPR041024|interpro:IPR041562|interpro:IPR001208(MCM)|mint:Q14566|rcsb pdb:2KLQ|rcsb pdb:2LE8|rcsb pdb:6XTX|rcsb pdb:6XTY|reactome:R-HSA-176187|reactome:R-HSA-176974|reactome:R-HSA-68867|reactome:R-HSA-68949|refseq:NP_005906.2|dip:DIP-31727N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:V+PXXBRM2zwlGQaeFiyjaQ9yf+A9606 rogid:gVpEwgfSwwxvP2T2CvCzIukthY49606 intact-crc:0247E0A3D2DA0BA0|rigid:YNzZdLlQUWY3+HOVHH44/ctr6C4 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q93009 uniprotkb:O43670 intact:EBI-302474|uniprotkb:A6NMY8|intact:EBI-28988230|ensembl:ENSP00000343535|uniprotkb:B7Z815|uniprotkb:H0Y3G8 intact:EBI-2513125|ensembl:ENSP00000322777|uniprotkb:A8K6Y6|uniprotkb:Q96HW5|uniprotkb:Q9BUQ7|uniprotkb:Q53XS9|uniprotkb:E1P661|uniprotkb:E1P662|uniprotkb:E1P660 psi-mi:ubp7_human(display_long)|uniprotkb:USP7(gene name)|psi-mi:USP7(display_short)|uniprotkb:HAUSP(gene name synonym)|uniprotkb:Ubiquitin thioesterase 7(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 7(gene name synonym)|uniprotkb:Deubiquitinating enzyme 7(gene name synonym)|uniprotkb:Herpesvirus-associated ubiquitin-specific protease(gene name synonym) psi-mi:zn207_human(display_long)|uniprotkb:ZNF207(gene name)|psi-mi:ZNF207(display_short)|uniprotkb:BUGZ(gene name synonym)|uniprotkb:Zinc finger protein 207(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513133|imex:IM-12079-80 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:4PYZ|rcsb pdb:4WPH|rcsb pdb:4WPI|rcsb pdb:4YOC|rcsb pdb:4YSI|rcsb pdb:4Z96|rcsb pdb:4Z97|rcsb pdb:5C56|rcsb pdb:5C6D|rcsb pdb:5FWI|rcsb pdb:5GG4|rcsb pdb:5J7T|rcsb pdb:5JTJ|rcsb pdb:5JTV|rcsb pdb:5KYB|rcsb pdb:4M5X|rcsb pdb:5KYC|rcsb pdb:5KYD|rcsb pdb:5KYE|rcsb pdb:5KYF|interpro:IPR029346|interpro:IPR038765|mint:Q93009|rcsb pdb:1NB8|rcsb pdb:1NBF|rcsb pdb:1YY6|rcsb pdb:1YZE|rcsb pdb:2F1W|rcsb pdb:2F1X|rcsb pdb:2F1Y|rcsb pdb:2F1Z|rcsb pdb:2FOJ|rcsb pdb:2FOO|rcsb pdb:2FOP|rcsb pdb:2KVR|rcsb pdb:2XXN|rcsb pdb:2YLM|rcsb pdb:3MQR|rcsb pdb:3MQS|rcsb pdb:4JJQ|rcsb pdb:4KG9|rcsb pdb:4M5W|go:"GO:0006283"(transcription-coupled nucleotide-excision repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010216"(maintenance of DNA methylation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035520"(monoubiquitinated protein deubiquitination)|go:"GO:0035616"(histone H2B conserved C-terminal lysine deubiquitination)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0048511"(rhythmic process)|go:"GO:0050821"(protein stabilization)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0101005"(deubiquitinase activity)|go:"GO:1901537"(positive regulation of DNA demethylation)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1904353"(regulation of telomere capping)|go:"GO:1905279"(regulation of retrograde transport, endosome to Golgi)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR018200|interpro:IPR024729|interpro:IPR028889|ensembl:ENSG00000187555(gene)|ensembl:ENST00000344836(transcript)|go:"GO:0002039"(p53 binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0006111"(regulation of gluconeogenesis)|rcsb pdb:5N9R|rcsb pdb:5N9T|rcsb pdb:5NGE|rcsb pdb:5NGF|rcsb pdb:5UQV|rcsb pdb:5UQX|rcsb pdb:5VS6|rcsb pdb:5VSB|rcsb pdb:5VSK|rcsb pdb:5WHC|rcsb pdb:6F5H|rcsb pdb:6M1K|rcsb pdb:6P5L|rcsb pdb:6VN2|rcsb pdb:6VN3|rcsb pdb:6VN4|rcsb pdb:6VN5|rcsb pdb:6VN6|rcsb pdb:7CM2|reactome:R-HSA-5689880|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6804757|reactome:R-HSA-8866652|reactome:R-HSA-8948747|refseq:NP_001273386.1|refseq:NP_003461.2|refseq:NP_001308787.1|ensembl:ENSP00000343535|ensembl:ENST00000381886|ensembl:ENSP00000371310|dip:DIP-29053N ensembl:ENSG00000010244(gene)|ensembl:ENST00000321233(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000776"(kinetochore)|go:"GO:0001578"(microtubule bundle formation)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005874"(microtubule)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0008017"(microtubule binding)|go:"GO:0008201"(heparin binding)|go:"GO:0008608"(attachment of spindle microtubules to kinetochore)|go:"GO:0046785"(microtubule polymerization)|go:"GO:0046872"(metal ion binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051301"(cell division)|go:"GO:0051983"(regulation of chromosome segregation)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:1990047"(spindle matrix)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|mint:O43670|refseq:NP_001027464.1|refseq:NP_001091977.1|refseq:NP_003448.1|refseq:XP_016880508.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:V+PXXBRM2zwlGQaeFiyjaQ9yf+A9606 rogid:yXD8JFABrqlAoAAPPECwHsUmFNc9606 intact-crc:0247E0A3D2DA0BA0|rigid:YNzZdLlQUWY3+HOVHH44/ctr6C4 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q93009 uniprotkb:Q9Y496 intact:EBI-302474|uniprotkb:A6NMY8|intact:EBI-28988230|ensembl:ENSP00000343535|uniprotkb:B7Z815|uniprotkb:H0Y3G8 intact:EBI-1104844|uniprotkb:Q59EN1|uniprotkb:Q86XE9|uniprotkb:Q9Y6V4|uniprotkb:A8MSW9|ensembl:ENSP00000368020 psi-mi:ubp7_human(display_long)|uniprotkb:USP7(gene name)|psi-mi:USP7(display_short)|uniprotkb:HAUSP(gene name synonym)|uniprotkb:Ubiquitin thioesterase 7(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 7(gene name synonym)|uniprotkb:Deubiquitinating enzyme 7(gene name synonym)|uniprotkb:Herpesvirus-associated ubiquitin-specific protease(gene name synonym) psi-mi:kif3a_human(display_long)|uniprotkb:KIF3A(gene name)|psi-mi:KIF3A(display_short)|uniprotkb:KIF3(gene name synonym)|uniprotkb:Microtubule plus end-directed kinesin motor 3A(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513133|imex:IM-12079-80 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:4PYZ|rcsb pdb:4WPH|rcsb pdb:4WPI|rcsb pdb:4YOC|rcsb pdb:4YSI|rcsb pdb:4Z96|rcsb pdb:4Z97|rcsb pdb:5C56|rcsb pdb:5C6D|rcsb pdb:5FWI|rcsb pdb:5GG4|rcsb pdb:5J7T|rcsb pdb:5JTJ|rcsb pdb:5JTV|rcsb pdb:5KYB|rcsb pdb:4M5X|rcsb pdb:5KYC|rcsb pdb:5KYD|rcsb pdb:5KYE|rcsb pdb:5KYF|interpro:IPR029346|interpro:IPR038765|mint:Q93009|rcsb pdb:1NB8|rcsb pdb:1NBF|rcsb pdb:1YY6|rcsb pdb:1YZE|rcsb pdb:2F1W|rcsb pdb:2F1X|rcsb pdb:2F1Y|rcsb pdb:2F1Z|rcsb pdb:2FOJ|rcsb pdb:2FOO|rcsb pdb:2FOP|rcsb pdb:2KVR|rcsb pdb:2XXN|rcsb pdb:2YLM|rcsb pdb:3MQR|rcsb pdb:3MQS|rcsb pdb:4JJQ|rcsb pdb:4KG9|rcsb pdb:4M5W|go:"GO:0006283"(transcription-coupled nucleotide-excision repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010216"(maintenance of DNA methylation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035520"(monoubiquitinated protein deubiquitination)|go:"GO:0035616"(histone H2B conserved C-terminal lysine deubiquitination)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0048511"(rhythmic process)|go:"GO:0050821"(protein stabilization)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0101005"(deubiquitinase activity)|go:"GO:1901537"(positive regulation of DNA demethylation)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1904353"(regulation of telomere capping)|go:"GO:1905279"(regulation of retrograde transport, endosome to Golgi)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR018200|interpro:IPR024729|interpro:IPR028889|ensembl:ENSG00000187555(gene)|ensembl:ENST00000344836(transcript)|go:"GO:0002039"(p53 binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0006111"(regulation of gluconeogenesis)|rcsb pdb:5N9R|rcsb pdb:5N9T|rcsb pdb:5NGE|rcsb pdb:5NGF|rcsb pdb:5UQV|rcsb pdb:5UQX|rcsb pdb:5VS6|rcsb pdb:5VSB|rcsb pdb:5VSK|rcsb pdb:5WHC|rcsb pdb:6F5H|rcsb pdb:6M1K|rcsb pdb:6P5L|rcsb pdb:6VN2|rcsb pdb:6VN3|rcsb pdb:6VN4|rcsb pdb:6VN5|rcsb pdb:6VN6|rcsb pdb:7CM2|reactome:R-HSA-5689880|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6804757|reactome:R-HSA-8866652|reactome:R-HSA-8948747|refseq:NP_001273386.1|refseq:NP_003461.2|refseq:NP_001308787.1|ensembl:ENSP00000343535|ensembl:ENST00000381886|ensembl:ENSP00000371310|dip:DIP-29053N refseq:NP_001287720.1|refseq:NP_001287721.1|go:"GO:0005524"(ATP binding)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|go:"GO:0005929"(cilium)|go:"GO:0006996"(organelle organization)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008574"(plus-end-directed microtubule motor activity)|go:"GO:0010457"(centriole-centriole cohesion)|go:"GO:0015031"(protein transport)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016939"(kinesin II complex)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030507"(spectrin binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0034454"(microtubule anchoring at centrosome)|go:"GO:0060271"(cilium assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072383"(plus-end-directed vesicle transport along microtubule)|go:"GO:0097542"(ciliary tip)|go:"GO:1902414"(protein localization to cell junction)|go:"GO:1904115"(axon cytoplasm)|interpro:IPR001752(Kinesin, motor region)|interpro:IPR019821|interpro:IPR027417|interpro:IPR027640|interpro:IPR036961|mint:Q9Y496|reactome:R-HSA-1445148|reactome:R-HSA-2132295|reactome:R-HSA-5610787|reactome:R-HSA-5620924|reactome:R-HSA-5635838|reactome:R-HSA-6811434|reactome:R-HSA-983189|ensembl:ENSG00000131437(gene)|ensembl:ENST00000378746(transcript)|go:"GO:0003777"(microtubule motor activity)|refseq:NP_008985.3|dip:DIP-33237N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:V+PXXBRM2zwlGQaeFiyjaQ9yf+A9606 rogid:mqR9jDCvk8dXn0mi2WvmnMNR1UQ9606 intact-crc:0247E0A3D2DA0BA0|rigid:YNzZdLlQUWY3+HOVHH44/ctr6C4 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q93009 uniprotkb:P49915 intact:EBI-302474|uniprotkb:A6NMY8|intact:EBI-28988230|ensembl:ENSP00000343535|uniprotkb:B7Z815|uniprotkb:H0Y3G8 intact:EBI-1050289|uniprotkb:A8K639|uniprotkb:B4DXV7|uniprotkb:F8W720|ensembl:ENSP00000419851 psi-mi:ubp7_human(display_long)|uniprotkb:USP7(gene name)|psi-mi:USP7(display_short)|uniprotkb:HAUSP(gene name synonym)|uniprotkb:Ubiquitin thioesterase 7(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 7(gene name synonym)|uniprotkb:Deubiquitinating enzyme 7(gene name synonym)|uniprotkb:Herpesvirus-associated ubiquitin-specific protease(gene name synonym) psi-mi:guaa_human(display_long)|uniprotkb:GMP synthetase(gene name synonym)|uniprotkb:Glutamine amidotransferase(gene name synonym)|uniprotkb:GMPS(gene name)|psi-mi:GMPS(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513133|imex:IM-12079-80 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:4PYZ|rcsb pdb:4WPH|rcsb pdb:4WPI|rcsb pdb:4YOC|rcsb pdb:4YSI|rcsb pdb:4Z96|rcsb pdb:4Z97|rcsb pdb:5C56|rcsb pdb:5C6D|rcsb pdb:5FWI|rcsb pdb:5GG4|rcsb pdb:5J7T|rcsb pdb:5JTJ|rcsb pdb:5JTV|rcsb pdb:5KYB|rcsb pdb:4M5X|rcsb pdb:5KYC|rcsb pdb:5KYD|rcsb pdb:5KYE|rcsb pdb:5KYF|interpro:IPR029346|interpro:IPR038765|mint:Q93009|rcsb pdb:1NB8|rcsb pdb:1NBF|rcsb pdb:1YY6|rcsb pdb:1YZE|rcsb pdb:2F1W|rcsb pdb:2F1X|rcsb pdb:2F1Y|rcsb pdb:2F1Z|rcsb pdb:2FOJ|rcsb pdb:2FOO|rcsb pdb:2FOP|rcsb pdb:2KVR|rcsb pdb:2XXN|rcsb pdb:2YLM|rcsb pdb:3MQR|rcsb pdb:3MQS|rcsb pdb:4JJQ|rcsb pdb:4KG9|rcsb pdb:4M5W|go:"GO:0006283"(transcription-coupled nucleotide-excision repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010216"(maintenance of DNA methylation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035520"(monoubiquitinated protein deubiquitination)|go:"GO:0035616"(histone H2B conserved C-terminal lysine deubiquitination)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0048511"(rhythmic process)|go:"GO:0050821"(protein stabilization)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0101005"(deubiquitinase activity)|go:"GO:1901537"(positive regulation of DNA demethylation)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1904353"(regulation of telomere capping)|go:"GO:1905279"(regulation of retrograde transport, endosome to Golgi)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR018200|interpro:IPR024729|interpro:IPR028889|ensembl:ENSG00000187555(gene)|ensembl:ENST00000344836(transcript)|go:"GO:0002039"(p53 binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0006111"(regulation of gluconeogenesis)|rcsb pdb:5N9R|rcsb pdb:5N9T|rcsb pdb:5NGE|rcsb pdb:5NGF|rcsb pdb:5UQV|rcsb pdb:5UQX|rcsb pdb:5VS6|rcsb pdb:5VSB|rcsb pdb:5VSK|rcsb pdb:5WHC|rcsb pdb:6F5H|rcsb pdb:6M1K|rcsb pdb:6P5L|rcsb pdb:6VN2|rcsb pdb:6VN3|rcsb pdb:6VN4|rcsb pdb:6VN5|rcsb pdb:6VN6|rcsb pdb:7CM2|reactome:R-HSA-5689880|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6804757|reactome:R-HSA-8866652|reactome:R-HSA-8948747|refseq:NP_001273386.1|refseq:NP_003461.2|refseq:NP_001308787.1|ensembl:ENSP00000343535|ensembl:ENST00000381886|ensembl:ENSP00000371310|dip:DIP-29053N refseq:NP_003866.1|ensembl:ENSG00000163655(gene)|ensembl:ENST00000496455(transcript)|go:"GO:0003921"(GMP synthase activity)|go:"GO:0003922"("GMP synthase (glutamine-hydrolyzing) activity")|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006177"(GMP biosynthetic process)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0009113"(purine nucleobase biosynthetic process)|go:"GO:0009168"(purine ribonucleoside monophosphate biosynthetic process)|go:"GO:0016462"(pyrophosphatase activity)|interpro:IPR001674(GMP synthase, C-terminal)|interpro:IPR004739(GMP synthase, N-terminal)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR017926|interpro:IPR022310|interpro:IPR025777|interpro:IPR029062|mint:P49915|rcsb pdb:2VPI|rcsb pdb:2VXO|reactome:R-HSA-73817 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:V+PXXBRM2zwlGQaeFiyjaQ9yf+A9606 rogid:LYs65bPoqjVG/ZxA6v+yJo3HsLI9606 intact-crc:0247E0A3D2DA0BA0|rigid:YNzZdLlQUWY3+HOVHH44/ctr6C4 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q93009 uniprotkb:Q6PIJ6 intact:EBI-302474|uniprotkb:A6NMY8|intact:EBI-28988230|ensembl:ENSP00000343535|uniprotkb:B7Z815|uniprotkb:H0Y3G8 intact:EBI-2513135|ensembl:ENSP00000342023|uniprotkb:Q9HC40|uniprotkb:Q86VN3|uniprotkb:Q7Z2U0|uniprotkb:Q9H837|uniprotkb:Q9BXY6|uniprotkb:Q6PK72 psi-mi:ubp7_human(display_long)|uniprotkb:USP7(gene name)|psi-mi:USP7(display_short)|uniprotkb:HAUSP(gene name synonym)|uniprotkb:Ubiquitin thioesterase 7(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 7(gene name synonym)|uniprotkb:Deubiquitinating enzyme 7(gene name synonym)|uniprotkb:Herpesvirus-associated ubiquitin-specific protease(gene name synonym) psi-mi:fbx38_human(display_long)|uniprotkb:FBXO38(gene name)|psi-mi:FBXO38(display_short)|uniprotkb:SP329(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513133|imex:IM-12079-80 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:4PYZ|rcsb pdb:4WPH|rcsb pdb:4WPI|rcsb pdb:4YOC|rcsb pdb:4YSI|rcsb pdb:4Z96|rcsb pdb:4Z97|rcsb pdb:5C56|rcsb pdb:5C6D|rcsb pdb:5FWI|rcsb pdb:5GG4|rcsb pdb:5J7T|rcsb pdb:5JTJ|rcsb pdb:5JTV|rcsb pdb:5KYB|rcsb pdb:4M5X|rcsb pdb:5KYC|rcsb pdb:5KYD|rcsb pdb:5KYE|rcsb pdb:5KYF|interpro:IPR029346|interpro:IPR038765|mint:Q93009|rcsb pdb:1NB8|rcsb pdb:1NBF|rcsb pdb:1YY6|rcsb pdb:1YZE|rcsb pdb:2F1W|rcsb pdb:2F1X|rcsb pdb:2F1Y|rcsb pdb:2F1Z|rcsb pdb:2FOJ|rcsb pdb:2FOO|rcsb pdb:2FOP|rcsb pdb:2KVR|rcsb pdb:2XXN|rcsb pdb:2YLM|rcsb pdb:3MQR|rcsb pdb:3MQS|rcsb pdb:4JJQ|rcsb pdb:4KG9|rcsb pdb:4M5W|go:"GO:0006283"(transcription-coupled nucleotide-excision repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010216"(maintenance of DNA methylation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035520"(monoubiquitinated protein deubiquitination)|go:"GO:0035616"(histone H2B conserved C-terminal lysine deubiquitination)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0048511"(rhythmic process)|go:"GO:0050821"(protein stabilization)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0101005"(deubiquitinase activity)|go:"GO:1901537"(positive regulation of DNA demethylation)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1904353"(regulation of telomere capping)|go:"GO:1905279"(regulation of retrograde transport, endosome to Golgi)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR018200|interpro:IPR024729|interpro:IPR028889|ensembl:ENSG00000187555(gene)|ensembl:ENST00000344836(transcript)|go:"GO:0002039"(p53 binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0006111"(regulation of gluconeogenesis)|rcsb pdb:5N9R|rcsb pdb:5N9T|rcsb pdb:5NGE|rcsb pdb:5NGF|rcsb pdb:5UQV|rcsb pdb:5UQX|rcsb pdb:5VS6|rcsb pdb:5VSB|rcsb pdb:5VSK|rcsb pdb:5WHC|rcsb pdb:6F5H|rcsb pdb:6M1K|rcsb pdb:6P5L|rcsb pdb:6VN2|rcsb pdb:6VN3|rcsb pdb:6VN4|rcsb pdb:6VN5|rcsb pdb:6VN6|rcsb pdb:7CM2|reactome:R-HSA-5689880|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6804757|reactome:R-HSA-8866652|reactome:R-HSA-8948747|refseq:NP_001273386.1|refseq:NP_003461.2|refseq:NP_001308787.1|ensembl:ENSP00000343535|ensembl:ENST00000381886|ensembl:ENSP00000371310|dip:DIP-29053N go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0070936"(protein K48-linked ubiquitination)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR036047|interpro:IPR042354|go:"GO:0005737"(cytoplasm)|ensembl:ENSG00000145868(gene)|ensembl:ENST00000340253(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002842"(positive regulation of T cell mediated immune response to tumor cell)|refseq:NP_110420.3|refseq:NP_001258652.1|refseq:XP_005268570.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:V+PXXBRM2zwlGQaeFiyjaQ9yf+A9606 rogid:/j2W7mAL7RdWukKthtgCaX3cV3k9606 intact-crc:0247E0A3D2DA0BA0|rigid:YNzZdLlQUWY3+HOVHH44/ctr6C4 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q93009 uniprotkb:P26358 intact:EBI-302474|uniprotkb:A6NMY8|intact:EBI-28988230|ensembl:ENSP00000343535|uniprotkb:B7Z815|uniprotkb:H0Y3G8 intact:EBI-719459|uniprotkb:Q9UHG5|uniprotkb:Q9ULA2|uniprotkb:Q9UMZ6|uniprotkb:A0AV63|intact:EBI-28971395|ensembl:ENSP00000345739|uniprotkb:B7ZLW6 psi-mi:ubp7_human(display_long)|uniprotkb:USP7(gene name)|psi-mi:USP7(display_short)|uniprotkb:HAUSP(gene name synonym)|uniprotkb:Ubiquitin thioesterase 7(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 7(gene name synonym)|uniprotkb:Deubiquitinating enzyme 7(gene name synonym)|uniprotkb:Herpesvirus-associated ubiquitin-specific protease(gene name synonym) psi-mi:dnmt1_human(display_long)|uniprotkb:CXXC9(gene name synonym)|uniprotkb:MCMT(gene name synonym)|uniprotkb:DNA methyltransferase HsaI(gene name synonym)|uniprotkb:CXXC-type zinc finger protein 9(gene name synonym)|uniprotkb:DNMT1(gene name)|psi-mi:DNMT1(display_short)|uniprotkb:AIM(gene name synonym)|uniprotkb:DNMT(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513133|imex:IM-12079-80 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:4PYZ|rcsb pdb:4WPH|rcsb pdb:4WPI|rcsb pdb:4YOC|rcsb pdb:4YSI|rcsb pdb:4Z96|rcsb pdb:4Z97|rcsb pdb:5C56|rcsb pdb:5C6D|rcsb pdb:5FWI|rcsb pdb:5GG4|rcsb pdb:5J7T|rcsb pdb:5JTJ|rcsb pdb:5JTV|rcsb pdb:5KYB|rcsb pdb:4M5X|rcsb pdb:5KYC|rcsb pdb:5KYD|rcsb pdb:5KYE|rcsb pdb:5KYF|interpro:IPR029346|interpro:IPR038765|mint:Q93009|rcsb pdb:1NB8|rcsb pdb:1NBF|rcsb pdb:1YY6|rcsb pdb:1YZE|rcsb pdb:2F1W|rcsb pdb:2F1X|rcsb pdb:2F1Y|rcsb pdb:2F1Z|rcsb pdb:2FOJ|rcsb pdb:2FOO|rcsb pdb:2FOP|rcsb pdb:2KVR|rcsb pdb:2XXN|rcsb pdb:2YLM|rcsb pdb:3MQR|rcsb pdb:3MQS|rcsb pdb:4JJQ|rcsb pdb:4KG9|rcsb pdb:4M5W|go:"GO:0006283"(transcription-coupled nucleotide-excision repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010216"(maintenance of DNA methylation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035520"(monoubiquitinated protein deubiquitination)|go:"GO:0035616"(histone H2B conserved C-terminal lysine deubiquitination)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0048511"(rhythmic process)|go:"GO:0050821"(protein stabilization)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0101005"(deubiquitinase activity)|go:"GO:1901537"(positive regulation of DNA demethylation)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1904353"(regulation of telomere capping)|go:"GO:1905279"(regulation of retrograde transport, endosome to Golgi)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR018200|interpro:IPR024729|interpro:IPR028889|ensembl:ENSG00000187555(gene)|ensembl:ENST00000344836(transcript)|go:"GO:0002039"(p53 binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0006111"(regulation of gluconeogenesis)|rcsb pdb:5N9R|rcsb pdb:5N9T|rcsb pdb:5NGE|rcsb pdb:5NGF|rcsb pdb:5UQV|rcsb pdb:5UQX|rcsb pdb:5VS6|rcsb pdb:5VSB|rcsb pdb:5VSK|rcsb pdb:5WHC|rcsb pdb:6F5H|rcsb pdb:6M1K|rcsb pdb:6P5L|rcsb pdb:6VN2|rcsb pdb:6VN3|rcsb pdb:6VN4|rcsb pdb:6VN5|rcsb pdb:6VN6|rcsb pdb:7CM2|reactome:R-HSA-5689880|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6804757|reactome:R-HSA-8866652|reactome:R-HSA-8948747|refseq:NP_001273386.1|refseq:NP_003461.2|refseq:NP_001308787.1|ensembl:ENSP00000343535|ensembl:ENST00000381886|ensembl:ENSP00000371310|dip:DIP-29053N ensembl:ENSP00000345739|ensembl:ENST00000359526|ensembl:ENSP00000352516|refseq:NP_001124295.1|refseq:NP_001370.1|ensembl:ENSG00000130816(gene)|ensembl:ENST00000340748(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003886"("DNA (cytosine-5-)-methyltransferase activity")|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0006306"(DNA methylation)|go:"GO:0006325"(chromatin organization)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008270"(zinc ion binding)|reactome:R-HSA-427413|reactome:R-HSA-4655427|reactome:R-HSA-5334118|reactome:R-HSA-9710421|refseq:NP_001305659.1|refseq:NP_001305660.1|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0009008"(DNA-methyltransferase activity)|go:"GO:0010216"(maintenance of DNA methylation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016458"(obsolete gene silencing)|go:"GO:0043045"(DNA methylation involved in embryo development)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051573"(negative regulation of histone H3-K9 methylation)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0090309"(positive regulation of DNA methylation-dependent heterochromatin assembly)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1905460"(negative regulation of vascular associated smooth muscle cell apoptotic process)|go:"GO:1905931"(negative regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR001025(Bromo adjacent region)|interpro:IPR001525(C-5 cytosine-specific DNA methylase)|interpro:IPR002857(Zinc finger, CXXC-type)|interpro:IPR010506(DMAP1-binding)|interpro:IPR017198("DNA (cytosine-5)-methyltransferase 1")|interpro:IPR018117|interpro:IPR022702|interpro:IPR029063|interpro:IPR031303|interpro:IPR043151|mint:P26358|rcsb pdb:3EPZ|rcsb pdb:3PTA|rcsb pdb:3SWR|rcsb pdb:4WXX|rcsb pdb:4YOC|rcsb pdb:4Z96|rcsb pdb:4Z97|rcsb pdb:5WVO|rcsb pdb:5YDR|rcsb pdb:6K3A|reactome:R-HSA-212300|dip:DIP-39693N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:V+PXXBRM2zwlGQaeFiyjaQ9yf+A9606 rogid:qae3zQwGP5R/+WCWoeahDKZ/9Jg9606 intact-crc:0247E0A3D2DA0BA0|rigid:YNzZdLlQUWY3+HOVHH44/ctr6C4 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q93009 uniprotkb:Q9BTE3 intact:EBI-302474|uniprotkb:A6NMY8|intact:EBI-28988230|ensembl:ENSP00000343535|uniprotkb:B7Z815|uniprotkb:H0Y3G8 intact:EBI-749378|uniprotkb:Q6IA56|uniprotkb:Q9BVT9|uniprotkb:Q9H916|uniprotkb:B3KSP7|ensembl:ENSP00000353098 psi-mi:ubp7_human(display_long)|uniprotkb:USP7(gene name)|psi-mi:USP7(display_short)|uniprotkb:HAUSP(gene name synonym)|uniprotkb:Ubiquitin thioesterase 7(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 7(gene name synonym)|uniprotkb:Deubiquitinating enzyme 7(gene name synonym)|uniprotkb:Herpesvirus-associated ubiquitin-specific protease(gene name synonym) psi-mi:mcmbp_human(display_long)|uniprotkb:MCMBP(gene name)|psi-mi:MCMBP(display_short)|uniprotkb:C10orf119(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513133|imex:IM-12079-80 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:4PYZ|rcsb pdb:4WPH|rcsb pdb:4WPI|rcsb pdb:4YOC|rcsb pdb:4YSI|rcsb pdb:4Z96|rcsb pdb:4Z97|rcsb pdb:5C56|rcsb pdb:5C6D|rcsb pdb:5FWI|rcsb pdb:5GG4|rcsb pdb:5J7T|rcsb pdb:5JTJ|rcsb pdb:5JTV|rcsb pdb:5KYB|rcsb pdb:4M5X|rcsb pdb:5KYC|rcsb pdb:5KYD|rcsb pdb:5KYE|rcsb pdb:5KYF|interpro:IPR029346|interpro:IPR038765|mint:Q93009|rcsb pdb:1NB8|rcsb pdb:1NBF|rcsb pdb:1YY6|rcsb pdb:1YZE|rcsb pdb:2F1W|rcsb pdb:2F1X|rcsb pdb:2F1Y|rcsb pdb:2F1Z|rcsb pdb:2FOJ|rcsb pdb:2FOO|rcsb pdb:2FOP|rcsb pdb:2KVR|rcsb pdb:2XXN|rcsb pdb:2YLM|rcsb pdb:3MQR|rcsb pdb:3MQS|rcsb pdb:4JJQ|rcsb pdb:4KG9|rcsb pdb:4M5W|go:"GO:0006283"(transcription-coupled nucleotide-excision repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010216"(maintenance of DNA methylation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035520"(monoubiquitinated protein deubiquitination)|go:"GO:0035616"(histone H2B conserved C-terminal lysine deubiquitination)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0048511"(rhythmic process)|go:"GO:0050821"(protein stabilization)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0101005"(deubiquitinase activity)|go:"GO:1901537"(positive regulation of DNA demethylation)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1904353"(regulation of telomere capping)|go:"GO:1905279"(regulation of retrograde transport, endosome to Golgi)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR018200|interpro:IPR024729|interpro:IPR028889|ensembl:ENSG00000187555(gene)|ensembl:ENST00000344836(transcript)|go:"GO:0002039"(p53 binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0006111"(regulation of gluconeogenesis)|rcsb pdb:5N9R|rcsb pdb:5N9T|rcsb pdb:5NGE|rcsb pdb:5NGF|rcsb pdb:5UQV|rcsb pdb:5UQX|rcsb pdb:5VS6|rcsb pdb:5VSB|rcsb pdb:5VSK|rcsb pdb:5WHC|rcsb pdb:6F5H|rcsb pdb:6M1K|rcsb pdb:6P5L|rcsb pdb:6VN2|rcsb pdb:6VN3|rcsb pdb:6VN4|rcsb pdb:6VN5|rcsb pdb:6VN6|rcsb pdb:7CM2|reactome:R-HSA-5689880|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6804757|reactome:R-HSA-8866652|reactome:R-HSA-8948747|refseq:NP_001273386.1|refseq:NP_003461.2|refseq:NP_001308787.1|ensembl:ENSP00000343535|ensembl:ENST00000381886|ensembl:ENSP00000371310|dip:DIP-29053N refseq:NP_079110.1|refseq:NP_001243307.1|refseq:NP_001243308.1|ensembl:ENSG00000197771(gene)|ensembl:ENST00000360003(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0030054"(cell junction)|go:"GO:0051301"(cell division)|interpro:IPR019140|rcsb pdb:4KG9 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:V+PXXBRM2zwlGQaeFiyjaQ9yf+A9606 rogid:8mXHWwvrQneZZArPvAEj1JZwOrg9606 intact-crc:0247E0A3D2DA0BA0|rigid:YNzZdLlQUWY3+HOVHH44/ctr6C4 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q93009 uniprotkb:P23588 intact:EBI-302474|uniprotkb:A6NMY8|intact:EBI-28988230|ensembl:ENSP00000343535|uniprotkb:B7Z815|uniprotkb:H0Y3G8 intact:EBI-970310|ensembl:ENSP00000262056|uniprotkb:Q4G0E3|uniprotkb:Q53HQ2|uniprotkb:Q6GPH5|uniprotkb:Q6IB46|uniprotkb:Q8WYK5|uniprotkb:B4DS13 psi-mi:ubp7_human(display_long)|uniprotkb:USP7(gene name)|psi-mi:USP7(display_short)|uniprotkb:HAUSP(gene name synonym)|uniprotkb:Ubiquitin thioesterase 7(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 7(gene name synonym)|uniprotkb:Deubiquitinating enzyme 7(gene name synonym)|uniprotkb:Herpesvirus-associated ubiquitin-specific protease(gene name synonym) psi-mi:if4b_human(display_long)|uniprotkb:EIF4B(gene name)|psi-mi:EIF4B(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513133|imex:IM-12079-80 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:4PYZ|rcsb pdb:4WPH|rcsb pdb:4WPI|rcsb pdb:4YOC|rcsb pdb:4YSI|rcsb pdb:4Z96|rcsb pdb:4Z97|rcsb pdb:5C56|rcsb pdb:5C6D|rcsb pdb:5FWI|rcsb pdb:5GG4|rcsb pdb:5J7T|rcsb pdb:5JTJ|rcsb pdb:5JTV|rcsb pdb:5KYB|rcsb pdb:4M5X|rcsb pdb:5KYC|rcsb pdb:5KYD|rcsb pdb:5KYE|rcsb pdb:5KYF|interpro:IPR029346|interpro:IPR038765|mint:Q93009|rcsb pdb:1NB8|rcsb pdb:1NBF|rcsb pdb:1YY6|rcsb pdb:1YZE|rcsb pdb:2F1W|rcsb pdb:2F1X|rcsb pdb:2F1Y|rcsb pdb:2F1Z|rcsb pdb:2FOJ|rcsb pdb:2FOO|rcsb pdb:2FOP|rcsb pdb:2KVR|rcsb pdb:2XXN|rcsb pdb:2YLM|rcsb pdb:3MQR|rcsb pdb:3MQS|rcsb pdb:4JJQ|rcsb pdb:4KG9|rcsb pdb:4M5W|go:"GO:0006283"(transcription-coupled nucleotide-excision repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010216"(maintenance of DNA methylation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035520"(monoubiquitinated protein deubiquitination)|go:"GO:0035616"(histone H2B conserved C-terminal lysine deubiquitination)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0048511"(rhythmic process)|go:"GO:0050821"(protein stabilization)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0101005"(deubiquitinase activity)|go:"GO:1901537"(positive regulation of DNA demethylation)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1904353"(regulation of telomere capping)|go:"GO:1905279"(regulation of retrograde transport, endosome to Golgi)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR018200|interpro:IPR024729|interpro:IPR028889|ensembl:ENSG00000187555(gene)|ensembl:ENST00000344836(transcript)|go:"GO:0002039"(p53 binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0006111"(regulation of gluconeogenesis)|rcsb pdb:5N9R|rcsb pdb:5N9T|rcsb pdb:5NGE|rcsb pdb:5NGF|rcsb pdb:5UQV|rcsb pdb:5UQX|rcsb pdb:5VS6|rcsb pdb:5VSB|rcsb pdb:5VSK|rcsb pdb:5WHC|rcsb pdb:6F5H|rcsb pdb:6M1K|rcsb pdb:6P5L|rcsb pdb:6VN2|rcsb pdb:6VN3|rcsb pdb:6VN4|rcsb pdb:6VN5|rcsb pdb:6VN6|rcsb pdb:7CM2|reactome:R-HSA-5689880|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6804757|reactome:R-HSA-8866652|reactome:R-HSA-8948747|refseq:NP_001273386.1|refseq:NP_003461.2|refseq:NP_001308787.1|ensembl:ENSP00000343535|ensembl:ENST00000381886|ensembl:ENSP00000371310|dip:DIP-29053N ensembl:ENSG00000063046(gene)|ensembl:ENST00000262056(transcript)|go:"GO:0001731"(formation of translation preinitiation complex)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0016281"(eukaryotic translation initiation factor 4F complex)|go:"GO:0030425"(dendrite)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034057"(RNA strand-exchange activity)|go:"GO:0043024"(ribosomal small subunit binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0097010"(eukaryotic translation initiation factor 4F complex assembly)|go:"GO:0098794"(postsynapse)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR033107|interpro:IPR035979|mint:P23588|rcsb pdb:1WI8|rcsb pdb:2J76|rcsb pdb:6FEC|reactome:R-HSA-156827|reactome:R-HSA-166208|reactome:R-HSA-429947|reactome:R-HSA-72649|reactome:R-HSA-72662|reactome:R-HSA-72702|reactome:R-HSA-72706|refseq:NP_001408.2|refseq:NP_001317583.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:V+PXXBRM2zwlGQaeFiyjaQ9yf+A9606 rogid:6QlRkSj6suC5apkUxdZhOq+OMBc9606 intact-crc:0247E0A3D2DA0BA0|rigid:YNzZdLlQUWY3+HOVHH44/ctr6C4 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q93009 uniprotkb:Q15018 intact:EBI-302474|uniprotkb:A6NMY8|intact:EBI-28988230|ensembl:ENSP00000343535|uniprotkb:B7Z815|uniprotkb:H0Y3G8 intact:EBI-1056583|uniprotkb:Q96H11|uniprotkb:B4DKR2|intact:EBI-28981592|ensembl:ENSP00000298492 psi-mi:ubp7_human(display_long)|uniprotkb:USP7(gene name)|psi-mi:USP7(display_short)|uniprotkb:HAUSP(gene name synonym)|uniprotkb:Ubiquitin thioesterase 7(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 7(gene name synonym)|uniprotkb:Deubiquitinating enzyme 7(gene name synonym)|uniprotkb:Herpesvirus-associated ubiquitin-specific protease(gene name synonym) psi-mi:abrx2_human(display_long)|uniprotkb:ABRAXAS2(gene name)|psi-mi:ABRAXAS2(display_short)|uniprotkb:ABRO1(gene name synonym)|uniprotkb:Abraxas brother protein 1(gene name synonym)|uniprotkb:FAM175B(gene name synonym)|uniprotkb:KIAA0157(gene name synonym)|uniprotkb:Protein FAM175B(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513133|imex:IM-12079-80 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:4PYZ|rcsb pdb:4WPH|rcsb pdb:4WPI|rcsb pdb:4YOC|rcsb pdb:4YSI|rcsb pdb:4Z96|rcsb pdb:4Z97|rcsb pdb:5C56|rcsb pdb:5C6D|rcsb pdb:5FWI|rcsb pdb:5GG4|rcsb pdb:5J7T|rcsb pdb:5JTJ|rcsb pdb:5JTV|rcsb pdb:5KYB|rcsb pdb:4M5X|rcsb pdb:5KYC|rcsb pdb:5KYD|rcsb pdb:5KYE|rcsb pdb:5KYF|interpro:IPR029346|interpro:IPR038765|mint:Q93009|rcsb pdb:1NB8|rcsb pdb:1NBF|rcsb pdb:1YY6|rcsb pdb:1YZE|rcsb pdb:2F1W|rcsb pdb:2F1X|rcsb pdb:2F1Y|rcsb pdb:2F1Z|rcsb pdb:2FOJ|rcsb pdb:2FOO|rcsb pdb:2FOP|rcsb pdb:2KVR|rcsb pdb:2XXN|rcsb pdb:2YLM|rcsb pdb:3MQR|rcsb pdb:3MQS|rcsb pdb:4JJQ|rcsb pdb:4KG9|rcsb pdb:4M5W|go:"GO:0006283"(transcription-coupled nucleotide-excision repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010216"(maintenance of DNA methylation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035520"(monoubiquitinated protein deubiquitination)|go:"GO:0035616"(histone H2B conserved C-terminal lysine deubiquitination)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0048511"(rhythmic process)|go:"GO:0050821"(protein stabilization)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0101005"(deubiquitinase activity)|go:"GO:1901537"(positive regulation of DNA demethylation)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1904353"(regulation of telomere capping)|go:"GO:1905279"(regulation of retrograde transport, endosome to Golgi)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR018200|interpro:IPR024729|interpro:IPR028889|ensembl:ENSG00000187555(gene)|ensembl:ENST00000344836(transcript)|go:"GO:0002039"(p53 binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0006111"(regulation of gluconeogenesis)|rcsb pdb:5N9R|rcsb pdb:5N9T|rcsb pdb:5NGE|rcsb pdb:5NGF|rcsb pdb:5UQV|rcsb pdb:5UQX|rcsb pdb:5VS6|rcsb pdb:5VSB|rcsb pdb:5VSK|rcsb pdb:5WHC|rcsb pdb:6F5H|rcsb pdb:6M1K|rcsb pdb:6P5L|rcsb pdb:6VN2|rcsb pdb:6VN3|rcsb pdb:6VN4|rcsb pdb:6VN5|rcsb pdb:6VN6|rcsb pdb:7CM2|reactome:R-HSA-5689880|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6804757|reactome:R-HSA-8866652|reactome:R-HSA-8948747|refseq:NP_001273386.1|refseq:NP_003461.2|refseq:NP_001308787.1|ensembl:ENSP00000343535|ensembl:ENST00000381886|ensembl:ENSP00000371310|dip:DIP-29053N ensembl:ENSP00000298492|refseq:NP_115558.3|ensembl:ENSG00000165660(gene)|ensembl:ENST00000298492(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000922"(spindle pole)|go:"GO:0002931"(response to ischemia)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0007059"(chromosome segregation)|go:"GO:0008017"(microtubule binding)|go:"GO:0008608"(attachment of spindle microtubules to kinetochore)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0051301"(cell division)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0070552"(BRISC complex)|go:"GO:0090307"(mitotic spindle assembly)|interpro:IPR023238|interpro:IPR023240|interpro:IPR037518|mint:Q15018|rcsb pdb:6H3C|rcsb pdb:6R8F|reactome:R-HSA-5689901 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:V+PXXBRM2zwlGQaeFiyjaQ9yf+A9606 rogid:fYZdQpH09qcBBUV1IKV2wsRk4m89606 intact-crc:0247E0A3D2DA0BA0|rigid:YNzZdLlQUWY3+HOVHH44/ctr6C4 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q93009 intact:EBI-2513107 intact:EBI-302474|uniprotkb:A6NMY8|intact:EBI-28988230|ensembl:ENSP00000343535|uniprotkb:B7Z815|uniprotkb:H0Y3G8 - psi-mi:ubp7_human(display_long)|uniprotkb:USP7(gene name)|psi-mi:USP7(display_short)|uniprotkb:HAUSP(gene name synonym)|uniprotkb:Ubiquitin thioesterase 7(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 7(gene name synonym)|uniprotkb:Deubiquitinating enzyme 7(gene name synonym)|uniprotkb:Herpesvirus-associated ubiquitin-specific protease(gene name synonym) psi-mi:c9jjy2_human(display_short)|psi-mi:EBI-2513107(display_long)|uniprotkb:RNF220(gene name)|psi-mi:RNF220(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513133|imex:IM-12079-80 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:4PYZ|rcsb pdb:4WPH|rcsb pdb:4WPI|rcsb pdb:4YOC|rcsb pdb:4YSI|rcsb pdb:4Z96|rcsb pdb:4Z97|rcsb pdb:5C56|rcsb pdb:5C6D|rcsb pdb:5FWI|rcsb pdb:5GG4|rcsb pdb:5J7T|rcsb pdb:5JTJ|rcsb pdb:5JTV|rcsb pdb:5KYB|rcsb pdb:4M5X|rcsb pdb:5KYC|rcsb pdb:5KYD|rcsb pdb:5KYE|rcsb pdb:5KYF|interpro:IPR029346|interpro:IPR038765|mint:Q93009|rcsb pdb:1NB8|rcsb pdb:1NBF|rcsb pdb:1YY6|rcsb pdb:1YZE|rcsb pdb:2F1W|rcsb pdb:2F1X|rcsb pdb:2F1Y|rcsb pdb:2F1Z|rcsb pdb:2FOJ|rcsb pdb:2FOO|rcsb pdb:2FOP|rcsb pdb:2KVR|rcsb pdb:2XXN|rcsb pdb:2YLM|rcsb pdb:3MQR|rcsb pdb:3MQS|rcsb pdb:4JJQ|rcsb pdb:4KG9|rcsb pdb:4M5W|go:"GO:0006283"(transcription-coupled nucleotide-excision repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010216"(maintenance of DNA methylation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035520"(monoubiquitinated protein deubiquitination)|go:"GO:0035616"(histone H2B conserved C-terminal lysine deubiquitination)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0048511"(rhythmic process)|go:"GO:0050821"(protein stabilization)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0101005"(deubiquitinase activity)|go:"GO:1901537"(positive regulation of DNA demethylation)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1904353"(regulation of telomere capping)|go:"GO:1905279"(regulation of retrograde transport, endosome to Golgi)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR018200|interpro:IPR024729|interpro:IPR028889|ensembl:ENSG00000187555(gene)|ensembl:ENST00000344836(transcript)|go:"GO:0002039"(p53 binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0006111"(regulation of gluconeogenesis)|rcsb pdb:5N9R|rcsb pdb:5N9T|rcsb pdb:5NGE|rcsb pdb:5NGF|rcsb pdb:5UQV|rcsb pdb:5UQX|rcsb pdb:5VS6|rcsb pdb:5VSB|rcsb pdb:5VSK|rcsb pdb:5WHC|rcsb pdb:6F5H|rcsb pdb:6M1K|rcsb pdb:6P5L|rcsb pdb:6VN2|rcsb pdb:6VN3|rcsb pdb:6VN4|rcsb pdb:6VN5|rcsb pdb:6VN6|rcsb pdb:7CM2|reactome:R-HSA-5689880|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6804757|reactome:R-HSA-8866652|reactome:R-HSA-8948747|refseq:NP_001273386.1|refseq:NP_003461.2|refseq:NP_001308787.1|ensembl:ENSP00000343535|ensembl:ENST00000381886|ensembl:ENSP00000371310|dip:DIP-29053N uniprotkb:C9JJY2(uniprot-removed-ac) psi-mi:"MI:0469"(intact) - no-uniprot-update:|caution:The sequence has been withdrawn from uniprot. figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:V+PXXBRM2zwlGQaeFiyjaQ9yf+A9606 rogid:atyYCPrRuCQKIeaHZABaCJx14ps9606 intact-crc:0247E0A3D2DA0BA0|rigid:YNzZdLlQUWY3+HOVHH44/ctr6C4 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q93009 uniprotkb:Q8WUA2 intact:EBI-302474|uniprotkb:A6NMY8|intact:EBI-28988230|ensembl:ENSP00000343535|uniprotkb:B7Z815|uniprotkb:H0Y3G8 intact:EBI-2513119|ensembl:ENSP00000253329|uniprotkb:B2RD34|uniprotkb:Q7Z3Q5 psi-mi:ubp7_human(display_long)|uniprotkb:USP7(gene name)|psi-mi:USP7(display_short)|uniprotkb:HAUSP(gene name synonym)|uniprotkb:Ubiquitin thioesterase 7(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 7(gene name synonym)|uniprotkb:Deubiquitinating enzyme 7(gene name synonym)|uniprotkb:Herpesvirus-associated ubiquitin-specific protease(gene name synonym) psi-mi:ppil4_human(display_long)|uniprotkb:PPIL4(gene name)|psi-mi:PPIL4(display_short)|uniprotkb:Cyclophilin-like protein PPIL4(gene name synonym)|uniprotkb:Rotamase PPIL4(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513133|imex:IM-12079-80 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:4PYZ|rcsb pdb:4WPH|rcsb pdb:4WPI|rcsb pdb:4YOC|rcsb pdb:4YSI|rcsb pdb:4Z96|rcsb pdb:4Z97|rcsb pdb:5C56|rcsb pdb:5C6D|rcsb pdb:5FWI|rcsb pdb:5GG4|rcsb pdb:5J7T|rcsb pdb:5JTJ|rcsb pdb:5JTV|rcsb pdb:5KYB|rcsb pdb:4M5X|rcsb pdb:5KYC|rcsb pdb:5KYD|rcsb pdb:5KYE|rcsb pdb:5KYF|interpro:IPR029346|interpro:IPR038765|mint:Q93009|rcsb pdb:1NB8|rcsb pdb:1NBF|rcsb pdb:1YY6|rcsb pdb:1YZE|rcsb pdb:2F1W|rcsb pdb:2F1X|rcsb pdb:2F1Y|rcsb pdb:2F1Z|rcsb pdb:2FOJ|rcsb pdb:2FOO|rcsb pdb:2FOP|rcsb pdb:2KVR|rcsb pdb:2XXN|rcsb pdb:2YLM|rcsb pdb:3MQR|rcsb pdb:3MQS|rcsb pdb:4JJQ|rcsb pdb:4KG9|rcsb pdb:4M5W|go:"GO:0006283"(transcription-coupled nucleotide-excision repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010216"(maintenance of DNA methylation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035520"(monoubiquitinated protein deubiquitination)|go:"GO:0035616"(histone H2B conserved C-terminal lysine deubiquitination)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0048511"(rhythmic process)|go:"GO:0050821"(protein stabilization)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0101005"(deubiquitinase activity)|go:"GO:1901537"(positive regulation of DNA demethylation)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1904353"(regulation of telomere capping)|go:"GO:1905279"(regulation of retrograde transport, endosome to Golgi)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR018200|interpro:IPR024729|interpro:IPR028889|ensembl:ENSG00000187555(gene)|ensembl:ENST00000344836(transcript)|go:"GO:0002039"(p53 binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0006111"(regulation of gluconeogenesis)|rcsb pdb:5N9R|rcsb pdb:5N9T|rcsb pdb:5NGE|rcsb pdb:5NGF|rcsb pdb:5UQV|rcsb pdb:5UQX|rcsb pdb:5VS6|rcsb pdb:5VSB|rcsb pdb:5VSK|rcsb pdb:5WHC|rcsb pdb:6F5H|rcsb pdb:6M1K|rcsb pdb:6P5L|rcsb pdb:6VN2|rcsb pdb:6VN3|rcsb pdb:6VN4|rcsb pdb:6VN5|rcsb pdb:6VN6|rcsb pdb:7CM2|reactome:R-HSA-5689880|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6804757|reactome:R-HSA-8866652|reactome:R-HSA-8948747|refseq:NP_001273386.1|refseq:NP_003461.2|refseq:NP_001308787.1|ensembl:ENSP00000343535|ensembl:ENST00000381886|ensembl:ENSP00000371310|dip:DIP-29053N go:"GO:1901407"(regulation of phosphorylation of RNA polymerase II C-terminal domain)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR002130(Peptidyl-prolyl cis-trans isomerase, cyclophilin-type)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR029000|interpro:IPR035538|interpro:IPR035542|interpro:IPR035979|mint:Q8WUA2|reactome:R-HSA-72163|go:"GO:0005829"(cytosol)|ensembl:ENSG00000131013(gene)|ensembl:ENST00000253329(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|refseq:NP_624311.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:V+PXXBRM2zwlGQaeFiyjaQ9yf+A9606 rogid:kxM/VRcLUG5M5FAlHuuAKRBKrd89606 intact-crc:0247E0A3D2DA0BA0|rigid:YNzZdLlQUWY3+HOVHH44/ctr6C4 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q93009 uniprotkb:P49750 intact:EBI-302474|uniprotkb:A6NMY8|intact:EBI-28988230|ensembl:ENSP00000343535|uniprotkb:B7Z815|uniprotkb:H0Y3G8 intact:EBI-712871|ensembl:ENSP00000324463|uniprotkb:P49752|uniprotkb:Q96I64|uniprotkb:Q9P1V7 psi-mi:ubp7_human(display_long)|uniprotkb:USP7(gene name)|psi-mi:USP7(display_short)|uniprotkb:HAUSP(gene name synonym)|uniprotkb:Ubiquitin thioesterase 7(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 7(gene name synonym)|uniprotkb:Deubiquitinating enzyme 7(gene name synonym)|uniprotkb:Herpesvirus-associated ubiquitin-specific protease(gene name synonym) psi-mi:ylpm1_human(display_long)|uniprotkb:Nuclear protein ZAP3(gene name synonym)|uniprotkb:ZAP113(gene name synonym)|uniprotkb:YLPM1(gene name)|psi-mi:YLPM1(display_short)|uniprotkb:C14orf170(gene name synonym)|uniprotkb:ZAP3(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513133|imex:IM-12079-80 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:4PYZ|rcsb pdb:4WPH|rcsb pdb:4WPI|rcsb pdb:4YOC|rcsb pdb:4YSI|rcsb pdb:4Z96|rcsb pdb:4Z97|rcsb pdb:5C56|rcsb pdb:5C6D|rcsb pdb:5FWI|rcsb pdb:5GG4|rcsb pdb:5J7T|rcsb pdb:5JTJ|rcsb pdb:5JTV|rcsb pdb:5KYB|rcsb pdb:4M5X|rcsb pdb:5KYC|rcsb pdb:5KYD|rcsb pdb:5KYE|rcsb pdb:5KYF|interpro:IPR029346|interpro:IPR038765|mint:Q93009|rcsb pdb:1NB8|rcsb pdb:1NBF|rcsb pdb:1YY6|rcsb pdb:1YZE|rcsb pdb:2F1W|rcsb pdb:2F1X|rcsb pdb:2F1Y|rcsb pdb:2F1Z|rcsb pdb:2FOJ|rcsb pdb:2FOO|rcsb pdb:2FOP|rcsb pdb:2KVR|rcsb pdb:2XXN|rcsb pdb:2YLM|rcsb pdb:3MQR|rcsb pdb:3MQS|rcsb pdb:4JJQ|rcsb pdb:4KG9|rcsb pdb:4M5W|go:"GO:0006283"(transcription-coupled nucleotide-excision repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010216"(maintenance of DNA methylation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035520"(monoubiquitinated protein deubiquitination)|go:"GO:0035616"(histone H2B conserved C-terminal lysine deubiquitination)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0048511"(rhythmic process)|go:"GO:0050821"(protein stabilization)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0101005"(deubiquitinase activity)|go:"GO:1901537"(positive regulation of DNA demethylation)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1904353"(regulation of telomere capping)|go:"GO:1905279"(regulation of retrograde transport, endosome to Golgi)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR018200|interpro:IPR024729|interpro:IPR028889|ensembl:ENSG00000187555(gene)|ensembl:ENST00000344836(transcript)|go:"GO:0002039"(p53 binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0006111"(regulation of gluconeogenesis)|rcsb pdb:5N9R|rcsb pdb:5N9T|rcsb pdb:5NGE|rcsb pdb:5NGF|rcsb pdb:5UQV|rcsb pdb:5UQX|rcsb pdb:5VS6|rcsb pdb:5VSB|rcsb pdb:5VSK|rcsb pdb:5WHC|rcsb pdb:6F5H|rcsb pdb:6M1K|rcsb pdb:6P5L|rcsb pdb:6VN2|rcsb pdb:6VN3|rcsb pdb:6VN4|rcsb pdb:6VN5|rcsb pdb:6VN6|rcsb pdb:7CM2|reactome:R-HSA-5689880|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6804757|reactome:R-HSA-8866652|reactome:R-HSA-8948747|refseq:NP_001273386.1|refseq:NP_003461.2|refseq:NP_001308787.1|ensembl:ENSP00000343535|ensembl:ENST00000381886|ensembl:ENSP00000371310|dip:DIP-29053N ensembl:ENSG00000119596(gene)|ensembl:ENST00000325680(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016607"(nuclear speck)|go:"GO:0032204"(regulation of telomere maintenance)|interpro:IPR026314|interpro:IPR027417|refseq:NP_062535.2|ensembl:ENSP00000324463|dip:DIP-53676N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:V+PXXBRM2zwlGQaeFiyjaQ9yf+A9606 rogid:3w+7odPC5D2UQYimwmCgTBbvWR49606 intact-crc:0247E0A3D2DA0BA0|rigid:YNzZdLlQUWY3+HOVHH44/ctr6C4 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q93009 uniprotkb:P33992 intact:EBI-302474|uniprotkb:A6NMY8|intact:EBI-28988230|ensembl:ENSP00000343535|uniprotkb:B7Z815|uniprotkb:H0Y3G8 intact:EBI-359410|ensembl:ENSP00000216122|uniprotkb:O60785|uniprotkb:Q14578|uniprotkb:Q9BTJ4|uniprotkb:Q9BWL8 psi-mi:ubp7_human(display_long)|uniprotkb:USP7(gene name)|psi-mi:USP7(display_short)|uniprotkb:HAUSP(gene name synonym)|uniprotkb:Ubiquitin thioesterase 7(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 7(gene name synonym)|uniprotkb:Deubiquitinating enzyme 7(gene name synonym)|uniprotkb:Herpesvirus-associated ubiquitin-specific protease(gene name synonym) psi-mi:mcm5_human(display_long)|uniprotkb:MCM5(gene name)|psi-mi:MCM5(display_short)|uniprotkb:CDC46(gene name synonym)|uniprotkb:CDC46 homolog(gene name synonym)|uniprotkb:P1-CDC46(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513133|imex:IM-12079-80 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:4PYZ|rcsb pdb:4WPH|rcsb pdb:4WPI|rcsb pdb:4YOC|rcsb pdb:4YSI|rcsb pdb:4Z96|rcsb pdb:4Z97|rcsb pdb:5C56|rcsb pdb:5C6D|rcsb pdb:5FWI|rcsb pdb:5GG4|rcsb pdb:5J7T|rcsb pdb:5JTJ|rcsb pdb:5JTV|rcsb pdb:5KYB|rcsb pdb:4M5X|rcsb pdb:5KYC|rcsb pdb:5KYD|rcsb pdb:5KYE|rcsb pdb:5KYF|interpro:IPR029346|interpro:IPR038765|mint:Q93009|rcsb pdb:1NB8|rcsb pdb:1NBF|rcsb pdb:1YY6|rcsb pdb:1YZE|rcsb pdb:2F1W|rcsb pdb:2F1X|rcsb pdb:2F1Y|rcsb pdb:2F1Z|rcsb pdb:2FOJ|rcsb pdb:2FOO|rcsb pdb:2FOP|rcsb pdb:2KVR|rcsb pdb:2XXN|rcsb pdb:2YLM|rcsb pdb:3MQR|rcsb pdb:3MQS|rcsb pdb:4JJQ|rcsb pdb:4KG9|rcsb pdb:4M5W|go:"GO:0006283"(transcription-coupled nucleotide-excision repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010216"(maintenance of DNA methylation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035520"(monoubiquitinated protein deubiquitination)|go:"GO:0035616"(histone H2B conserved C-terminal lysine deubiquitination)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0048511"(rhythmic process)|go:"GO:0050821"(protein stabilization)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0101005"(deubiquitinase activity)|go:"GO:1901537"(positive regulation of DNA demethylation)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1904353"(regulation of telomere capping)|go:"GO:1905279"(regulation of retrograde transport, endosome to Golgi)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR018200|interpro:IPR024729|interpro:IPR028889|ensembl:ENSG00000187555(gene)|ensembl:ENST00000344836(transcript)|go:"GO:0002039"(p53 binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0006111"(regulation of gluconeogenesis)|rcsb pdb:5N9R|rcsb pdb:5N9T|rcsb pdb:5NGE|rcsb pdb:5NGF|rcsb pdb:5UQV|rcsb pdb:5UQX|rcsb pdb:5VS6|rcsb pdb:5VSB|rcsb pdb:5VSK|rcsb pdb:5WHC|rcsb pdb:6F5H|rcsb pdb:6M1K|rcsb pdb:6P5L|rcsb pdb:6VN2|rcsb pdb:6VN3|rcsb pdb:6VN4|rcsb pdb:6VN5|rcsb pdb:6VN6|rcsb pdb:7CM2|reactome:R-HSA-5689880|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6804757|reactome:R-HSA-8866652|reactome:R-HSA-8948747|refseq:NP_001273386.1|refseq:NP_003461.2|refseq:NP_001308787.1|ensembl:ENSP00000343535|ensembl:ENST00000381886|ensembl:ENSP00000371310|dip:DIP-29053N ensembl:ENSG00000100297(gene)|ensembl:ENST00000216122(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0016020"(membrane)|go:"GO:0042555"(MCM complex)|go:"GO:0071162"(CMG complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001208(MCM)|interpro:IPR008048(MCM protein 5)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR018525|interpro:IPR027417|interpro:IPR027925|interpro:IPR031327|interpro:IPR033762|interpro:IPR041562|mint:P33992|rcsb pdb:6XTX|rcsb pdb:6XTY|reactome:R-HSA-176187|reactome:R-HSA-176974|reactome:R-HSA-68867|reactome:R-HSA-68949|refseq:NP_006730.2|reactome:R-HSA-69052|reactome:R-HSA-68962|dip:DIP-27578N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:V+PXXBRM2zwlGQaeFiyjaQ9yf+A9606 rogid:WjJ4lSpADQFtwT0WnumbRHl/lPw9606 intact-crc:0247E0A3D2DA0BA0|rigid:YNzZdLlQUWY3+HOVHH44/ctr6C4 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q93009 uniprotkb:Q92667 intact:EBI-302474|uniprotkb:A6NMY8|intact:EBI-28988230|ensembl:ENSP00000343535|uniprotkb:B7Z815|uniprotkb:H0Y3G8 intact:EBI-2119593|uniprotkb:Q13320|uniprotkb:Q9BW14|uniprotkb:A8K8Q1|uniprotkb:D3DTZ0|ensembl:ENSP00000337736|ensembl:ENSP00000443139|ensembl:ENSP00000459895|ensembl:ENSP00000459968|ensembl:ENSP00000478212 psi-mi:ubp7_human(display_long)|uniprotkb:USP7(gene name)|psi-mi:USP7(display_short)|uniprotkb:HAUSP(gene name synonym)|uniprotkb:Ubiquitin thioesterase 7(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 7(gene name synonym)|uniprotkb:Deubiquitinating enzyme 7(gene name synonym)|uniprotkb:Herpesvirus-associated ubiquitin-specific protease(gene name synonym) psi-mi:akap1_human(display_long)|uniprotkb:AKAP1(gene name)|psi-mi:AKAP1(display_short)|uniprotkb:AKAP149(gene name synonym)|uniprotkb:PRKA1(gene name synonym)|uniprotkb:Protein kinase A-anchoring protein 1(gene name synonym)|uniprotkb:A-kinase anchor protein 149 kDa(gene name synonym)|uniprotkb:Dual specificity A-kinase-anchoring protein 1(gene name synonym)|uniprotkb:Spermatid A-kinase anchor protein 84(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513133|imex:IM-12079-80 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:4PYZ|rcsb pdb:4WPH|rcsb pdb:4WPI|rcsb pdb:4YOC|rcsb pdb:4YSI|rcsb pdb:4Z96|rcsb pdb:4Z97|rcsb pdb:5C56|rcsb pdb:5C6D|rcsb pdb:5FWI|rcsb pdb:5GG4|rcsb pdb:5J7T|rcsb pdb:5JTJ|rcsb pdb:5JTV|rcsb pdb:5KYB|rcsb pdb:4M5X|rcsb pdb:5KYC|rcsb pdb:5KYD|rcsb pdb:5KYE|rcsb pdb:5KYF|interpro:IPR029346|interpro:IPR038765|mint:Q93009|rcsb pdb:1NB8|rcsb pdb:1NBF|rcsb pdb:1YY6|rcsb pdb:1YZE|rcsb pdb:2F1W|rcsb pdb:2F1X|rcsb pdb:2F1Y|rcsb pdb:2F1Z|rcsb pdb:2FOJ|rcsb pdb:2FOO|rcsb pdb:2FOP|rcsb pdb:2KVR|rcsb pdb:2XXN|rcsb pdb:2YLM|rcsb pdb:3MQR|rcsb pdb:3MQS|rcsb pdb:4JJQ|rcsb pdb:4KG9|rcsb pdb:4M5W|go:"GO:0006283"(transcription-coupled nucleotide-excision repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010216"(maintenance of DNA methylation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035520"(monoubiquitinated protein deubiquitination)|go:"GO:0035616"(histone H2B conserved C-terminal lysine deubiquitination)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0048511"(rhythmic process)|go:"GO:0050821"(protein stabilization)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0101005"(deubiquitinase activity)|go:"GO:1901537"(positive regulation of DNA demethylation)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1904353"(regulation of telomere capping)|go:"GO:1905279"(regulation of retrograde transport, endosome to Golgi)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR018200|interpro:IPR024729|interpro:IPR028889|ensembl:ENSG00000187555(gene)|ensembl:ENST00000344836(transcript)|go:"GO:0002039"(p53 binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0006111"(regulation of gluconeogenesis)|rcsb pdb:5N9R|rcsb pdb:5N9T|rcsb pdb:5NGE|rcsb pdb:5NGF|rcsb pdb:5UQV|rcsb pdb:5UQX|rcsb pdb:5VS6|rcsb pdb:5VSB|rcsb pdb:5VSK|rcsb pdb:5WHC|rcsb pdb:6F5H|rcsb pdb:6M1K|rcsb pdb:6P5L|rcsb pdb:6VN2|rcsb pdb:6VN3|rcsb pdb:6VN4|rcsb pdb:6VN5|rcsb pdb:6VN6|rcsb pdb:7CM2|reactome:R-HSA-5689880|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6804757|reactome:R-HSA-8866652|reactome:R-HSA-8948747|refseq:NP_001273386.1|refseq:NP_003461.2|refseq:NP_001308787.1|ensembl:ENSP00000343535|ensembl:ENST00000381886|ensembl:ENSP00000371310|dip:DIP-29053N refseq:XP_016880678.1|refseq:XP_016880679.1|refseq:XP_016880680.1|refseq:NP_001229831.1|refseq:NP_001229832.1|refseq:NP_003479.1|refseq:XP_005257764.1|refseq:XP_005257766.1|ensembl:ENSG00000121057(gene)|ensembl:ENST00000337714(transcript)|ensembl:ENST00000539273(transcript)|ensembl:ENST00000571629(transcript)|ensembl:ENST00000572557(transcript)|ensembl:ENST00000621116(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0140374"(antiviral innate immune response)|interpro:IPR002999(Tudor)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR035437|interpro:IPR036612|mint:Q92667|reactome:R-HSA-8949215|reactome:R-HSA-983231 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:V+PXXBRM2zwlGQaeFiyjaQ9yf+A9606 rogid:8HzwuoBdBWw+LZKg6WpYxMKnfYE9606 intact-crc:0247E0A3D2DA0BA0|rigid:YNzZdLlQUWY3+HOVHH44/ctr6C4 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q93009 uniprotkb:Q9NXR7 intact:EBI-302474|uniprotkb:A6NMY8|intact:EBI-28988230|ensembl:ENSP00000343535|uniprotkb:B7Z815|uniprotkb:H0Y3G8 intact:EBI-949389|ensembl:ENSP00000339371|ensembl:ENSP00000368945|uniprotkb:Q13880|uniprotkb:Q96P06|uniprotkb:A8K4X1|uniprotkb:Q4ZFX8|uniprotkb:Q53SD0|uniprotkb:Q969X9|uniprotkb:D6W562|uniprotkb:D6W563 psi-mi:ubp7_human(display_long)|uniprotkb:USP7(gene name)|psi-mi:USP7(display_short)|uniprotkb:HAUSP(gene name synonym)|uniprotkb:Ubiquitin thioesterase 7(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 7(gene name synonym)|uniprotkb:Deubiquitinating enzyme 7(gene name synonym)|uniprotkb:Herpesvirus-associated ubiquitin-specific protease(gene name synonym) psi-mi:baba2_human(display_long)|uniprotkb:BABAM2(gene name)|psi-mi:BABAM2(display_short)|uniprotkb:BRCA1-A complex subunit BRE(gene name synonym)|uniprotkb:BRCA1/BRCA2-containing complex subunit 45(gene name synonym)|uniprotkb:BRCC45(gene name synonym)|uniprotkb:BRE(gene name synonym)|uniprotkb:Brain and reproductive organ-expressed protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513133|imex:IM-12079-80 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:4PYZ|rcsb pdb:4WPH|rcsb pdb:4WPI|rcsb pdb:4YOC|rcsb pdb:4YSI|rcsb pdb:4Z96|rcsb pdb:4Z97|rcsb pdb:5C56|rcsb pdb:5C6D|rcsb pdb:5FWI|rcsb pdb:5GG4|rcsb pdb:5J7T|rcsb pdb:5JTJ|rcsb pdb:5JTV|rcsb pdb:5KYB|rcsb pdb:4M5X|rcsb pdb:5KYC|rcsb pdb:5KYD|rcsb pdb:5KYE|rcsb pdb:5KYF|interpro:IPR029346|interpro:IPR038765|mint:Q93009|rcsb pdb:1NB8|rcsb pdb:1NBF|rcsb pdb:1YY6|rcsb pdb:1YZE|rcsb pdb:2F1W|rcsb pdb:2F1X|rcsb pdb:2F1Y|rcsb pdb:2F1Z|rcsb pdb:2FOJ|rcsb pdb:2FOO|rcsb pdb:2FOP|rcsb pdb:2KVR|rcsb pdb:2XXN|rcsb pdb:2YLM|rcsb pdb:3MQR|rcsb pdb:3MQS|rcsb pdb:4JJQ|rcsb pdb:4KG9|rcsb pdb:4M5W|go:"GO:0006283"(transcription-coupled nucleotide-excision repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010216"(maintenance of DNA methylation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035520"(monoubiquitinated protein deubiquitination)|go:"GO:0035616"(histone H2B conserved C-terminal lysine deubiquitination)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0048511"(rhythmic process)|go:"GO:0050821"(protein stabilization)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0101005"(deubiquitinase activity)|go:"GO:1901537"(positive regulation of DNA demethylation)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1904353"(regulation of telomere capping)|go:"GO:1905279"(regulation of retrograde transport, endosome to Golgi)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR018200|interpro:IPR024729|interpro:IPR028889|ensembl:ENSG00000187555(gene)|ensembl:ENST00000344836(transcript)|go:"GO:0002039"(p53 binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0006111"(regulation of gluconeogenesis)|rcsb pdb:5N9R|rcsb pdb:5N9T|rcsb pdb:5NGE|rcsb pdb:5NGF|rcsb pdb:5UQV|rcsb pdb:5UQX|rcsb pdb:5VS6|rcsb pdb:5VSB|rcsb pdb:5VSK|rcsb pdb:5WHC|rcsb pdb:6F5H|rcsb pdb:6M1K|rcsb pdb:6P5L|rcsb pdb:6VN2|rcsb pdb:6VN3|rcsb pdb:6VN4|rcsb pdb:6VN5|rcsb pdb:6VN6|rcsb pdb:7CM2|reactome:R-HSA-5689880|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6804757|reactome:R-HSA-8866652|reactome:R-HSA-8948747|refseq:NP_001273386.1|refseq:NP_003461.2|refseq:NP_001308787.1|ensembl:ENSP00000343535|ensembl:ENST00000381886|ensembl:ENSP00000371310|dip:DIP-29053N ensembl:ENSG00000158019(gene)|ensembl:ENST00000342045(transcript)|ensembl:ENST00000379624(transcript)|go:"GO:0000152"(nuclear ubiquitin ligase complex)|go:"GO:0000268"(peroxisome targeting sequence binding)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0007165"(signal transduction)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0051301"(cell division)|go:"GO:0070531"(BRCA1-A complex)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0070552"(BRISC complex)|interpro:IPR010358(Brain and reproductive organ-expressed)|rcsb pdb:6H3C|rcsb pdb:6R8F|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473|go:"GO:0006302"(double-strand break repair)|refseq:NP_004890.2|refseq:NP_954661.1|refseq:NP_954662.1|refseq:NP_954663.1|refseq:NP_954664.1|refseq:NP_001248769.1|refseq:NP_001316041.1|refseq:NP_001316042.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:V+PXXBRM2zwlGQaeFiyjaQ9yf+A9606 rogid:ULbrw0O7e5M0Hzho3d05OlUnEGM9606 intact-crc:0247E0A3D2DA0BA0|rigid:YNzZdLlQUWY3+HOVHH44/ctr6C4 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q93009 uniprotkb:P54578 intact:EBI-302474|uniprotkb:A6NMY8|intact:EBI-28988230|ensembl:ENSP00000343535|uniprotkb:B7Z815|uniprotkb:H0Y3G8 intact:EBI-1048016|uniprotkb:Q53XY5|uniprotkb:B7Z4N8|uniprotkb:J3QRZ5|ensembl:ENSP00000261601 psi-mi:ubp7_human(display_long)|uniprotkb:USP7(gene name)|psi-mi:USP7(display_short)|uniprotkb:HAUSP(gene name synonym)|uniprotkb:Ubiquitin thioesterase 7(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 7(gene name synonym)|uniprotkb:Deubiquitinating enzyme 7(gene name synonym)|uniprotkb:Herpesvirus-associated ubiquitin-specific protease(gene name synonym) psi-mi:ubp14_human(display_long)|uniprotkb:USP14(gene name)|psi-mi:USP14(display_short)|uniprotkb:TGT(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 14(gene name synonym)|uniprotkb:Deubiquitinating enzyme 14(gene name synonym)|uniprotkb:Ubiquitin thioesterase 14(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513133|imex:IM-12079-80 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:4PYZ|rcsb pdb:4WPH|rcsb pdb:4WPI|rcsb pdb:4YOC|rcsb pdb:4YSI|rcsb pdb:4Z96|rcsb pdb:4Z97|rcsb pdb:5C56|rcsb pdb:5C6D|rcsb pdb:5FWI|rcsb pdb:5GG4|rcsb pdb:5J7T|rcsb pdb:5JTJ|rcsb pdb:5JTV|rcsb pdb:5KYB|rcsb pdb:4M5X|rcsb pdb:5KYC|rcsb pdb:5KYD|rcsb pdb:5KYE|rcsb pdb:5KYF|interpro:IPR029346|interpro:IPR038765|mint:Q93009|rcsb pdb:1NB8|rcsb pdb:1NBF|rcsb pdb:1YY6|rcsb pdb:1YZE|rcsb pdb:2F1W|rcsb pdb:2F1X|rcsb pdb:2F1Y|rcsb pdb:2F1Z|rcsb pdb:2FOJ|rcsb pdb:2FOO|rcsb pdb:2FOP|rcsb pdb:2KVR|rcsb pdb:2XXN|rcsb pdb:2YLM|rcsb pdb:3MQR|rcsb pdb:3MQS|rcsb pdb:4JJQ|rcsb pdb:4KG9|rcsb pdb:4M5W|go:"GO:0006283"(transcription-coupled nucleotide-excision repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010216"(maintenance of DNA methylation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035520"(monoubiquitinated protein deubiquitination)|go:"GO:0035616"(histone H2B conserved C-terminal lysine deubiquitination)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0048511"(rhythmic process)|go:"GO:0050821"(protein stabilization)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0101005"(deubiquitinase activity)|go:"GO:1901537"(positive regulation of DNA demethylation)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1904353"(regulation of telomere capping)|go:"GO:1905279"(regulation of retrograde transport, endosome to Golgi)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR018200|interpro:IPR024729|interpro:IPR028889|ensembl:ENSG00000187555(gene)|ensembl:ENST00000344836(transcript)|go:"GO:0002039"(p53 binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0006111"(regulation of gluconeogenesis)|rcsb pdb:5N9R|rcsb pdb:5N9T|rcsb pdb:5NGE|rcsb pdb:5NGF|rcsb pdb:5UQV|rcsb pdb:5UQX|rcsb pdb:5VS6|rcsb pdb:5VSB|rcsb pdb:5VSK|rcsb pdb:5WHC|rcsb pdb:6F5H|rcsb pdb:6M1K|rcsb pdb:6P5L|rcsb pdb:6VN2|rcsb pdb:6VN3|rcsb pdb:6VN4|rcsb pdb:6VN5|rcsb pdb:6VN6|rcsb pdb:7CM2|reactome:R-HSA-5689880|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6804757|reactome:R-HSA-8866652|reactome:R-HSA-8948747|refseq:NP_001273386.1|refseq:NP_003461.2|refseq:NP_001308787.1|ensembl:ENSP00000343535|ensembl:ENST00000381886|ensembl:ENSP00000371310|dip:DIP-29053N refseq:NP_001032411.1|refseq:NP_005142.1|ensembl:ENSG00000101557(gene)|ensembl:ENST00000261601(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0050920"(regulation of chemotaxis)|go:"GO:0045087"(innate immune response)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:1903070"(negative regulation of ER-associated ubiquitin-dependent protein catabolic process)|interpro:IPR000626(Ubiquitin)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR019954|interpro:IPR028889|interpro:IPR029071|interpro:IPR038765|interpro:IPR044635|mint:P54578|rcsb pdb:2AYN|rcsb pdb:2AYO|rcsb pdb:5GJQ|rcsb pdb:6IIK|rcsb pdb:6IIL|rcsb pdb:6IIM|rcsb pdb:6IIN|rcsb pdb:6LVS|reactome:R-HSA-5689880|go:"GO:0070628"(proteasome binding) psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:V+PXXBRM2zwlGQaeFiyjaQ9yf+A9606 rogid:5hXfHmHds5nuvdlFYWoB/G6nvmk9606 intact-crc:0247E0A3D2DA0BA0|rigid:YNzZdLlQUWY3+HOVHH44/ctr6C4 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q93009 uniprotkb:P78347 intact:EBI-302474|uniprotkb:A6NMY8|intact:EBI-28988230|ensembl:ENSP00000343535|uniprotkb:B7Z815|uniprotkb:H0Y3G8 intact:EBI-359622|uniprotkb:Q75M88|uniprotkb:O14743|uniprotkb:O15359|uniprotkb:O43546|uniprotkb:O43588|uniprotkb:O43589|uniprotkb:Q9BSZ4|uniprotkb:Q86U51|uniprotkb:Q75M85|uniprotkb:Q75M86|uniprotkb:Q75M87|ensembl:ENSP00000460070 psi-mi:ubp7_human(display_long)|uniprotkb:USP7(gene name)|psi-mi:USP7(display_short)|uniprotkb:HAUSP(gene name synonym)|uniprotkb:Ubiquitin thioesterase 7(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 7(gene name synonym)|uniprotkb:Deubiquitinating enzyme 7(gene name synonym)|uniprotkb:Herpesvirus-associated ubiquitin-specific protease(gene name synonym) psi-mi:gtf2i_human(display_long)|uniprotkb:GTF2I(gene name)|psi-mi:GTF2I(display_short)|uniprotkb:BAP135(gene name synonym)|uniprotkb:WBSCR6(gene name synonym)|uniprotkb:Bruton tyrosine kinase-associated protein 135(gene name synonym)|uniprotkb:SRF-Phox1-interacting protein(gene name synonym)|uniprotkb:Williams-Beuren syndrome chromosomal region 6 protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513133|imex:IM-12079-80 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:4PYZ|rcsb pdb:4WPH|rcsb pdb:4WPI|rcsb pdb:4YOC|rcsb pdb:4YSI|rcsb pdb:4Z96|rcsb pdb:4Z97|rcsb pdb:5C56|rcsb pdb:5C6D|rcsb pdb:5FWI|rcsb pdb:5GG4|rcsb pdb:5J7T|rcsb pdb:5JTJ|rcsb pdb:5JTV|rcsb pdb:5KYB|rcsb pdb:4M5X|rcsb pdb:5KYC|rcsb pdb:5KYD|rcsb pdb:5KYE|rcsb pdb:5KYF|interpro:IPR029346|interpro:IPR038765|mint:Q93009|rcsb pdb:1NB8|rcsb pdb:1NBF|rcsb pdb:1YY6|rcsb pdb:1YZE|rcsb pdb:2F1W|rcsb pdb:2F1X|rcsb pdb:2F1Y|rcsb pdb:2F1Z|rcsb pdb:2FOJ|rcsb pdb:2FOO|rcsb pdb:2FOP|rcsb pdb:2KVR|rcsb pdb:2XXN|rcsb pdb:2YLM|rcsb pdb:3MQR|rcsb pdb:3MQS|rcsb pdb:4JJQ|rcsb pdb:4KG9|rcsb pdb:4M5W|go:"GO:0006283"(transcription-coupled nucleotide-excision repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010216"(maintenance of DNA methylation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035520"(monoubiquitinated protein deubiquitination)|go:"GO:0035616"(histone H2B conserved C-terminal lysine deubiquitination)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0048511"(rhythmic process)|go:"GO:0050821"(protein stabilization)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0101005"(deubiquitinase activity)|go:"GO:1901537"(positive regulation of DNA demethylation)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1904353"(regulation of telomere capping)|go:"GO:1905279"(regulation of retrograde transport, endosome to Golgi)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR018200|interpro:IPR024729|interpro:IPR028889|ensembl:ENSG00000187555(gene)|ensembl:ENST00000344836(transcript)|go:"GO:0002039"(p53 binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0006111"(regulation of gluconeogenesis)|rcsb pdb:5N9R|rcsb pdb:5N9T|rcsb pdb:5NGE|rcsb pdb:5NGF|rcsb pdb:5UQV|rcsb pdb:5UQX|rcsb pdb:5VS6|rcsb pdb:5VSB|rcsb pdb:5VSK|rcsb pdb:5WHC|rcsb pdb:6F5H|rcsb pdb:6M1K|rcsb pdb:6P5L|rcsb pdb:6VN2|rcsb pdb:6VN3|rcsb pdb:6VN4|rcsb pdb:6VN5|rcsb pdb:6VN6|rcsb pdb:7CM2|reactome:R-HSA-5689880|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6804757|reactome:R-HSA-8866652|reactome:R-HSA-8948747|refseq:NP_001273386.1|refseq:NP_003461.2|refseq:NP_001308787.1|ensembl:ENSP00000343535|ensembl:ENST00000381886|ensembl:ENSP00000371310|dip:DIP-29053N refseq:NP_001509.3|refseq:NP_127492.1|refseq:NP_127493.1|refseq:NP_127494.1|ensembl:ENSG00000263001(gene)|ensembl:ENST00000573035(transcript)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0016020"(membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0100026"(positive regulation of DNA repair by transcription from RNA polymerase II promoter)|interpro:IPR004212(GTF2I-like repeat)|interpro:IPR016659(Transcription factor II-I)|mint:P78347|rcsb pdb:2D9B|rcsb pdb:2DN4|rcsb pdb:2ED2|rcsb pdb:2EJE|interpro:IPR036647|refseq:NP_001157108.1|refseq:NP_001267729.1|dip:DIP-24252N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:V+PXXBRM2zwlGQaeFiyjaQ9yf+A9606 rogid:DqfrIS0Ey+XvZfTXmk9KQzBtQo49606 intact-crc:0247E0A3D2DA0BA0|rigid:YNzZdLlQUWY3+HOVHH44/ctr6C4 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q93009 uniprotkb:P46109 intact:EBI-302474|uniprotkb:A6NMY8|intact:EBI-28988230|ensembl:ENSP00000343535|uniprotkb:B7Z815|uniprotkb:H0Y3G8 intact:EBI-910|uniprotkb:A8KA44|intact:EBI-3451075|uniprotkb:D3DX35|ensembl:ENSP00000346300|ensembl:ENSP00000396646 psi-mi:ubp7_human(display_long)|uniprotkb:USP7(gene name)|psi-mi:USP7(display_short)|uniprotkb:HAUSP(gene name synonym)|uniprotkb:Ubiquitin thioesterase 7(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 7(gene name synonym)|uniprotkb:Deubiquitinating enzyme 7(gene name synonym)|uniprotkb:Herpesvirus-associated ubiquitin-specific protease(gene name synonym) psi-mi:crkl_human(display_long)|uniprotkb:CRKL(gene name)|psi-mi:CRKL(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513133|imex:IM-12079-80 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:4PYZ|rcsb pdb:4WPH|rcsb pdb:4WPI|rcsb pdb:4YOC|rcsb pdb:4YSI|rcsb pdb:4Z96|rcsb pdb:4Z97|rcsb pdb:5C56|rcsb pdb:5C6D|rcsb pdb:5FWI|rcsb pdb:5GG4|rcsb pdb:5J7T|rcsb pdb:5JTJ|rcsb pdb:5JTV|rcsb pdb:5KYB|rcsb pdb:4M5X|rcsb pdb:5KYC|rcsb pdb:5KYD|rcsb pdb:5KYE|rcsb pdb:5KYF|interpro:IPR029346|interpro:IPR038765|mint:Q93009|rcsb pdb:1NB8|rcsb pdb:1NBF|rcsb pdb:1YY6|rcsb pdb:1YZE|rcsb pdb:2F1W|rcsb pdb:2F1X|rcsb pdb:2F1Y|rcsb pdb:2F1Z|rcsb pdb:2FOJ|rcsb pdb:2FOO|rcsb pdb:2FOP|rcsb pdb:2KVR|rcsb pdb:2XXN|rcsb pdb:2YLM|rcsb pdb:3MQR|rcsb pdb:3MQS|rcsb pdb:4JJQ|rcsb pdb:4KG9|rcsb pdb:4M5W|go:"GO:0006283"(transcription-coupled nucleotide-excision repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010216"(maintenance of DNA methylation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035520"(monoubiquitinated protein deubiquitination)|go:"GO:0035616"(histone H2B conserved C-terminal lysine deubiquitination)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0048511"(rhythmic process)|go:"GO:0050821"(protein stabilization)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0101005"(deubiquitinase activity)|go:"GO:1901537"(positive regulation of DNA demethylation)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1904353"(regulation of telomere capping)|go:"GO:1905279"(regulation of retrograde transport, endosome to Golgi)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR018200|interpro:IPR024729|interpro:IPR028889|ensembl:ENSG00000187555(gene)|ensembl:ENST00000344836(transcript)|go:"GO:0002039"(p53 binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0006111"(regulation of gluconeogenesis)|rcsb pdb:5N9R|rcsb pdb:5N9T|rcsb pdb:5NGE|rcsb pdb:5NGF|rcsb pdb:5UQV|rcsb pdb:5UQX|rcsb pdb:5VS6|rcsb pdb:5VSB|rcsb pdb:5VSK|rcsb pdb:5WHC|rcsb pdb:6F5H|rcsb pdb:6M1K|rcsb pdb:6P5L|rcsb pdb:6VN2|rcsb pdb:6VN3|rcsb pdb:6VN4|rcsb pdb:6VN5|rcsb pdb:6VN6|rcsb pdb:7CM2|reactome:R-HSA-5689880|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6804757|reactome:R-HSA-8866652|reactome:R-HSA-8948747|refseq:NP_001273386.1|refseq:NP_003461.2|refseq:NP_001308787.1|ensembl:ENSP00000343535|ensembl:ENST00000381886|ensembl:ENSP00000371310|dip:DIP-29053N refseq:NP_005198.1|dip:DIP-29165N|ensembl:ENSG00000099942(gene)|ensembl:ENST00000354336(transcript)|ensembl:ENST00000411769(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001568"(blood vessel development)|go:"GO:0001655"(urogenital system development)|go:"GO:0001764"(neuron migration)|go:"GO:0001783"(B cell apoptotic process)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0007254"(JNK cascade)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0007416"(synapse assembly)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0008584"(male gonad development)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016358"(dendrite development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035685"(helper T cell diapedesis)|go:"GO:0035690"|go:"GO:0038026"(reelin-mediated signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0048384"(retinoic acid receptor signaling pathway)|go:"GO:0048538"(thymus development)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0060017"(parathyroid gland development)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0060465"(pharynx development)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0086100"(endothelin receptor signaling pathway)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0095500"(acetylcholine receptor signaling pathway)|go:"GO:0098749"(cerebellar neuron development)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:0098890"(extrinsic component of postsynaptic membrane)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1903977"(positive regulation of glial cell migration)|go:"GO:1904393"(regulation of skeletal muscle acetylcholine-gated channel clustering)|go:"GO:1904888"(cranial skeletal system development)|go:"GO:2000404"(regulation of T cell migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035457|interpro:IPR035458|interpro:IPR036028|interpro:IPR036860|mint:P46109|rcsb pdb:2BZX|rcsb pdb:2BZY|rcsb pdb:2DBK|rcsb pdb:2EO3|rcsb pdb:2LQN|rcsb pdb:2LQW|reactome:R-HSA-170968|reactome:R-HSA-186763|reactome:R-HSA-8875555|reactome:R-HSA-8875656|reactome:R-HSA-9027284|reactome:R-HSA-912631 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:V+PXXBRM2zwlGQaeFiyjaQ9yf+A9606 rogid:1YwlbUPPuijisz7AJM4Qkp7yJBI9606 intact-crc:0247E0A3D2DA0BA0|rigid:YNzZdLlQUWY3+HOVHH44/ctr6C4 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q93009 uniprotkb:P33991 intact:EBI-302474|uniprotkb:A6NMY8|intact:EBI-28988230|ensembl:ENSP00000343535|uniprotkb:B7Z815|uniprotkb:H0Y3G8 intact:EBI-374938|uniprotkb:Q8NEH1|uniprotkb:Q99658|ensembl:ENSP00000262105|ensembl:ENSP00000496964 psi-mi:ubp7_human(display_long)|uniprotkb:USP7(gene name)|psi-mi:USP7(display_short)|uniprotkb:HAUSP(gene name synonym)|uniprotkb:Ubiquitin thioesterase 7(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 7(gene name synonym)|uniprotkb:Deubiquitinating enzyme 7(gene name synonym)|uniprotkb:Herpesvirus-associated ubiquitin-specific protease(gene name synonym) psi-mi:mcm4_human(display_long)|uniprotkb:MCM4(gene name)|psi-mi:MCM4(display_short)|uniprotkb:CDC21(gene name synonym)|uniprotkb:CDC21 homolog(gene name synonym)|uniprotkb:P1-CDC21(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513133|imex:IM-12079-80 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:4PYZ|rcsb pdb:4WPH|rcsb pdb:4WPI|rcsb pdb:4YOC|rcsb pdb:4YSI|rcsb pdb:4Z96|rcsb pdb:4Z97|rcsb pdb:5C56|rcsb pdb:5C6D|rcsb pdb:5FWI|rcsb pdb:5GG4|rcsb pdb:5J7T|rcsb pdb:5JTJ|rcsb pdb:5JTV|rcsb pdb:5KYB|rcsb pdb:4M5X|rcsb pdb:5KYC|rcsb pdb:5KYD|rcsb pdb:5KYE|rcsb pdb:5KYF|interpro:IPR029346|interpro:IPR038765|mint:Q93009|rcsb pdb:1NB8|rcsb pdb:1NBF|rcsb pdb:1YY6|rcsb pdb:1YZE|rcsb pdb:2F1W|rcsb pdb:2F1X|rcsb pdb:2F1Y|rcsb pdb:2F1Z|rcsb pdb:2FOJ|rcsb pdb:2FOO|rcsb pdb:2FOP|rcsb pdb:2KVR|rcsb pdb:2XXN|rcsb pdb:2YLM|rcsb pdb:3MQR|rcsb pdb:3MQS|rcsb pdb:4JJQ|rcsb pdb:4KG9|rcsb pdb:4M5W|go:"GO:0006283"(transcription-coupled nucleotide-excision repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010216"(maintenance of DNA methylation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035520"(monoubiquitinated protein deubiquitination)|go:"GO:0035616"(histone H2B conserved C-terminal lysine deubiquitination)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0048511"(rhythmic process)|go:"GO:0050821"(protein stabilization)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0101005"(deubiquitinase activity)|go:"GO:1901537"(positive regulation of DNA demethylation)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1904353"(regulation of telomere capping)|go:"GO:1905279"(regulation of retrograde transport, endosome to Golgi)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR018200|interpro:IPR024729|interpro:IPR028889|ensembl:ENSG00000187555(gene)|ensembl:ENST00000344836(transcript)|go:"GO:0002039"(p53 binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0006111"(regulation of gluconeogenesis)|rcsb pdb:5N9R|rcsb pdb:5N9T|rcsb pdb:5NGE|rcsb pdb:5NGF|rcsb pdb:5UQV|rcsb pdb:5UQX|rcsb pdb:5VS6|rcsb pdb:5VSB|rcsb pdb:5VSK|rcsb pdb:5WHC|rcsb pdb:6F5H|rcsb pdb:6M1K|rcsb pdb:6P5L|rcsb pdb:6VN2|rcsb pdb:6VN3|rcsb pdb:6VN4|rcsb pdb:6VN5|rcsb pdb:6VN6|rcsb pdb:7CM2|reactome:R-HSA-5689880|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6804757|reactome:R-HSA-8866652|reactome:R-HSA-8948747|refseq:NP_001273386.1|refseq:NP_003461.2|refseq:NP_001308787.1|ensembl:ENSP00000343535|ensembl:ENST00000381886|ensembl:ENSP00000371310|dip:DIP-29053N refseq:NP_005905.2|refseq:NP_877423.1|ensembl:ENSG00000104738(gene)|ensembl:ENST00000262105(transcript)|ensembl:ENST00000649973(transcript)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006260"(DNA replication)|go:"GO:0006267"(pre-replicative complex assembly involved in nuclear cell cycle DNA replication)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006271"(DNA strand elongation involved in DNA replication)|go:"GO:0016020"(membrane)|go:"GO:0042555"(MCM complex)|go:"GO:0071162"(CMG complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902975"(mitotic DNA replication initiation)|interpro:IPR001208(MCM)|interpro:IPR008047(MCM protein 4)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR018525|interpro:IPR027417|interpro:IPR027925|interpro:IPR031327|interpro:IPR033762|interpro:IPR041562|mint:P33991|rcsb pdb:6XTX|rcsb pdb:6XTY|reactome:R-HSA-176187|reactome:R-HSA-176974|reactome:R-HSA-68867|reactome:R-HSA-68949|reactome:R-HSA-68962|reactome:R-HSA-69052|dip:DIP-31729N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:V+PXXBRM2zwlGQaeFiyjaQ9yf+A9606 rogid:emFkamsHmwBPzoJnPcaL4SaqAlU9606 intact-crc:0247E0A3D2DA0BA0|rigid:YNzZdLlQUWY3+HOVHH44/ctr6C4 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q93009 uniprotkb:P52948 intact:EBI-302474|uniprotkb:A6NMY8|intact:EBI-28988230|ensembl:ENSP00000343535|uniprotkb:B7Z815|uniprotkb:H0Y3G8 intact:EBI-295727|uniprotkb:Q8IUT2|uniprotkb:Q8WYB0|uniprotkb:Q96E54|uniprotkb:Q9H3Q4|uniprotkb:Q9NT02|uniprotkb:Q9UF57|uniprotkb:Q9UHX0|uniprotkb:Q9Y6J4|uniprotkb:Q9Y6J5|ensembl:ENSP00000352091 psi-mi:ubp7_human(display_long)|uniprotkb:USP7(gene name)|psi-mi:USP7(display_short)|uniprotkb:HAUSP(gene name synonym)|uniprotkb:Ubiquitin thioesterase 7(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 7(gene name synonym)|uniprotkb:Deubiquitinating enzyme 7(gene name synonym)|uniprotkb:Herpesvirus-associated ubiquitin-specific protease(gene name synonym) psi-mi:nup98_human(display_long)|uniprotkb:NUP98(gene name)|psi-mi:NUP98(display_short)|uniprotkb:ADAR2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513133|imex:IM-12079-80 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:4PYZ|rcsb pdb:4WPH|rcsb pdb:4WPI|rcsb pdb:4YOC|rcsb pdb:4YSI|rcsb pdb:4Z96|rcsb pdb:4Z97|rcsb pdb:5C56|rcsb pdb:5C6D|rcsb pdb:5FWI|rcsb pdb:5GG4|rcsb pdb:5J7T|rcsb pdb:5JTJ|rcsb pdb:5JTV|rcsb pdb:5KYB|rcsb pdb:4M5X|rcsb pdb:5KYC|rcsb pdb:5KYD|rcsb pdb:5KYE|rcsb pdb:5KYF|interpro:IPR029346|interpro:IPR038765|mint:Q93009|rcsb pdb:1NB8|rcsb pdb:1NBF|rcsb pdb:1YY6|rcsb pdb:1YZE|rcsb pdb:2F1W|rcsb pdb:2F1X|rcsb pdb:2F1Y|rcsb pdb:2F1Z|rcsb pdb:2FOJ|rcsb pdb:2FOO|rcsb pdb:2FOP|rcsb pdb:2KVR|rcsb pdb:2XXN|rcsb pdb:2YLM|rcsb pdb:3MQR|rcsb pdb:3MQS|rcsb pdb:4JJQ|rcsb pdb:4KG9|rcsb pdb:4M5W|go:"GO:0006283"(transcription-coupled nucleotide-excision repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010216"(maintenance of DNA methylation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035520"(monoubiquitinated protein deubiquitination)|go:"GO:0035616"(histone H2B conserved C-terminal lysine deubiquitination)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0048511"(rhythmic process)|go:"GO:0050821"(protein stabilization)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0101005"(deubiquitinase activity)|go:"GO:1901537"(positive regulation of DNA demethylation)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1904353"(regulation of telomere capping)|go:"GO:1905279"(regulation of retrograde transport, endosome to Golgi)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR018200|interpro:IPR024729|interpro:IPR028889|ensembl:ENSG00000187555(gene)|ensembl:ENST00000344836(transcript)|go:"GO:0002039"(p53 binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0006111"(regulation of gluconeogenesis)|rcsb pdb:5N9R|rcsb pdb:5N9T|rcsb pdb:5NGE|rcsb pdb:5NGF|rcsb pdb:5UQV|rcsb pdb:5UQX|rcsb pdb:5VS6|rcsb pdb:5VSB|rcsb pdb:5VSK|rcsb pdb:5WHC|rcsb pdb:6F5H|rcsb pdb:6M1K|rcsb pdb:6P5L|rcsb pdb:6VN2|rcsb pdb:6VN3|rcsb pdb:6VN4|rcsb pdb:6VN5|rcsb pdb:6VN6|rcsb pdb:7CM2|reactome:R-HSA-5689880|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6804757|reactome:R-HSA-8866652|reactome:R-HSA-8948747|refseq:NP_001273386.1|refseq:NP_003461.2|refseq:NP_001308787.1|ensembl:ENSP00000343535|ensembl:ENST00000381886|ensembl:ENSP00000371310|dip:DIP-29053N refseq:NP_005378.4|refseq:NP_057404.2|refseq:NP_624357.1|refseq:NP_624358.2|ensembl:ENST00000324932|ensembl:ENSP00000316032|ensembl:ENST00000355260|ensembl:ENSP00000347404|ensembl:ENSP00000352091|ensembl:ENST00000397004|ensembl:ENSP00000380199|ensembl:ENST00000397007|ensembl:ENSP00000380202|dip:DIP-32484N|ensembl:ENSG00000110713(gene)|ensembl:ENST00000359171(transcript)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003729"(mRNA binding)|go:"GO:0005215"(transporter activity)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006913"(nucleocytoplasmic transport)|go:"GO:0006999"(nuclear pore organization)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0016604"(nuclear body)|go:"GO:0017056"(structural constituent of nuclear pore)|go:"GO:0031080"(nuclear pore outer ring)|go:"GO:0031965"(nuclear membrane)|go:"GO:0034399"(nuclear periphery)|go:"GO:0042405"(nuclear inclusion body)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044615"(nuclear pore nuclear basket)|go:"GO:0048026"(positive regulation of mRNA splicing, via spliceosome)|go:"GO:0051028"(mRNA transport)|go:"GO:0051292"(nuclear pore complex assembly)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR007230(Peptidase S59, nucleoporin)|interpro:IPR021967|interpro:IPR036903|interpro:IPR037637|interpro:IPR037665|mint:P52948|rcsb pdb:1KO6|rcsb pdb:2Q5X|rcsb pdb:2Q5Y|rcsb pdb:3MMY|rcsb pdb:4OWR|rcsb pdb:5A9Q|rcsb pdb:6BZM|reactome:R-HSA-1169408|reactome:R-HSA-141444|reactome:R-HSA-159227|reactome:R-HSA-159230|reactome:R-HSA-159231|reactome:R-HSA-159236|reactome:R-HSA-165054|reactome:R-HSA-168271|reactome:R-HSA-168276|reactome:R-HSA-168325|reactome:R-HSA-168333|reactome:R-HSA-170822|reactome:R-HSA-180746|reactome:R-HSA-180910|reactome:R-HSA-191859|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-3108214|reactome:R-HSA-3232142|reactome:R-HSA-3301854|reactome:R-HSA-3371453|reactome:R-HSA-4085377|reactome:R-HSA-4551638|reactome:R-HSA-4570464|reactome:R-HSA-4615885|reactome:R-HSA-5578749|reactome:R-HSA-5619107|reactome:R-HSA-5663220|reactome:R-HSA-6784531|reactome:R-HSA-68877|reactome:R-HSA-9609690|reactome:R-HSA-9610379|reactome:R-HSA-9615933|reactome:R-HSA-9648025 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:V+PXXBRM2zwlGQaeFiyjaQ9yf+A9606 rogid:aW9NaKgLZti0wLEiVQogGukcWdE9606 intact-crc:0247E0A3D2DA0BA0|rigid:YNzZdLlQUWY3+HOVHH44/ctr6C4 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q93009 uniprotkb:O15355 intact:EBI-302474|uniprotkb:A6NMY8|intact:EBI-28988230|ensembl:ENSP00000343535|uniprotkb:B7Z815|uniprotkb:H0Y3G8 intact:EBI-725702|ensembl:ENSP00000342778 psi-mi:ubp7_human(display_long)|uniprotkb:USP7(gene name)|psi-mi:USP7(display_short)|uniprotkb:HAUSP(gene name synonym)|uniprotkb:Ubiquitin thioesterase 7(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 7(gene name synonym)|uniprotkb:Deubiquitinating enzyme 7(gene name synonym)|uniprotkb:Herpesvirus-associated ubiquitin-specific protease(gene name synonym) psi-mi:ppm1g_human(display_long)|uniprotkb:Protein phosphatase 2C isoform gamma(gene name synonym)|uniprotkb:Protein phosphatase magnesium-dependent 1 gamma(gene name synonym)|uniprotkb:Protein phosphatase 1C(gene name synonym)|uniprotkb:PPM1G(gene name)|psi-mi:PPM1G(display_short)|uniprotkb:PPM1C(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513133|imex:IM-12079-80 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:4PYZ|rcsb pdb:4WPH|rcsb pdb:4WPI|rcsb pdb:4YOC|rcsb pdb:4YSI|rcsb pdb:4Z96|rcsb pdb:4Z97|rcsb pdb:5C56|rcsb pdb:5C6D|rcsb pdb:5FWI|rcsb pdb:5GG4|rcsb pdb:5J7T|rcsb pdb:5JTJ|rcsb pdb:5JTV|rcsb pdb:5KYB|rcsb pdb:4M5X|rcsb pdb:5KYC|rcsb pdb:5KYD|rcsb pdb:5KYE|rcsb pdb:5KYF|interpro:IPR029346|interpro:IPR038765|mint:Q93009|rcsb pdb:1NB8|rcsb pdb:1NBF|rcsb pdb:1YY6|rcsb pdb:1YZE|rcsb pdb:2F1W|rcsb pdb:2F1X|rcsb pdb:2F1Y|rcsb pdb:2F1Z|rcsb pdb:2FOJ|rcsb pdb:2FOO|rcsb pdb:2FOP|rcsb pdb:2KVR|rcsb pdb:2XXN|rcsb pdb:2YLM|rcsb pdb:3MQR|rcsb pdb:3MQS|rcsb pdb:4JJQ|rcsb pdb:4KG9|rcsb pdb:4M5W|go:"GO:0006283"(transcription-coupled nucleotide-excision repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010216"(maintenance of DNA methylation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035520"(monoubiquitinated protein deubiquitination)|go:"GO:0035616"(histone H2B conserved C-terminal lysine deubiquitination)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0048511"(rhythmic process)|go:"GO:0050821"(protein stabilization)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0101005"(deubiquitinase activity)|go:"GO:1901537"(positive regulation of DNA demethylation)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1904353"(regulation of telomere capping)|go:"GO:1905279"(regulation of retrograde transport, endosome to Golgi)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR018200|interpro:IPR024729|interpro:IPR028889|ensembl:ENSG00000187555(gene)|ensembl:ENST00000344836(transcript)|go:"GO:0002039"(p53 binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0006111"(regulation of gluconeogenesis)|rcsb pdb:5N9R|rcsb pdb:5N9T|rcsb pdb:5NGE|rcsb pdb:5NGF|rcsb pdb:5UQV|rcsb pdb:5UQX|rcsb pdb:5VS6|rcsb pdb:5VSB|rcsb pdb:5VSK|rcsb pdb:5WHC|rcsb pdb:6F5H|rcsb pdb:6M1K|rcsb pdb:6P5L|rcsb pdb:6VN2|rcsb pdb:6VN3|rcsb pdb:6VN4|rcsb pdb:6VN5|rcsb pdb:6VN6|rcsb pdb:7CM2|reactome:R-HSA-5689880|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6804757|reactome:R-HSA-8866652|reactome:R-HSA-8948747|refseq:NP_001273386.1|refseq:NP_003461.2|refseq:NP_001308787.1|ensembl:ENSP00000343535|ensembl:ENST00000381886|ensembl:ENSP00000371310|dip:DIP-29053N refseq:NP_817092.1|ensembl:ENST00000344034(transcript)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006470"(protein dephosphorylation)|ensembl:ENSG00000115241(gene)|go:"GO:0016020"(membrane)|go:"GO:0035970"(peptidyl-threonine dephosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0106306"|go:"GO:0106307"|interpro:IPR000222(Protein phosphatase 2C, manganese/magnesium aspartate binding site)|interpro:IPR001932(Protein phosphatase 2C-related)|interpro:IPR015655(Protein phosphatase 2C)|interpro:IPR036457|mint:O15355|dip:DIP-29404N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:V+PXXBRM2zwlGQaeFiyjaQ9yf+A9606 rogid:j9ut2f7QHVyOtsLuYJ8e2XOP3HE9606 intact-crc:0247E0A3D2DA0BA0|rigid:YNzZdLlQUWY3+HOVHH44/ctr6C4 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q93009 uniprotkb:O43684 intact:EBI-302474|uniprotkb:A6NMY8|intact:EBI-28988230|ensembl:ENSP00000343535|uniprotkb:B7Z815|uniprotkb:H0Y3G8 intact:EBI-1050987|uniprotkb:O43685|uniprotkb:B2R6E7|uniprotkb:A6NJ42|uniprotkb:D3DRE9|ensembl:ENSP00000357858 psi-mi:ubp7_human(display_long)|uniprotkb:USP7(gene name)|psi-mi:USP7(display_short)|uniprotkb:HAUSP(gene name synonym)|uniprotkb:Ubiquitin thioesterase 7(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 7(gene name synonym)|uniprotkb:Deubiquitinating enzyme 7(gene name synonym)|uniprotkb:Herpesvirus-associated ubiquitin-specific protease(gene name synonym) psi-mi:bub3_human(display_long)|uniprotkb:BUB3(gene name)|psi-mi:BUB3(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513133|imex:IM-12079-80 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rcsb pdb:4PYZ|rcsb pdb:4WPH|rcsb pdb:4WPI|rcsb pdb:4YOC|rcsb pdb:4YSI|rcsb pdb:4Z96|rcsb pdb:4Z97|rcsb pdb:5C56|rcsb pdb:5C6D|rcsb pdb:5FWI|rcsb pdb:5GG4|rcsb pdb:5J7T|rcsb pdb:5JTJ|rcsb pdb:5JTV|rcsb pdb:5KYB|rcsb pdb:4M5X|rcsb pdb:5KYC|rcsb pdb:5KYD|rcsb pdb:5KYE|rcsb pdb:5KYF|interpro:IPR029346|interpro:IPR038765|mint:Q93009|rcsb pdb:1NB8|rcsb pdb:1NBF|rcsb pdb:1YY6|rcsb pdb:1YZE|rcsb pdb:2F1W|rcsb pdb:2F1X|rcsb pdb:2F1Y|rcsb pdb:2F1Z|rcsb pdb:2FOJ|rcsb pdb:2FOO|rcsb pdb:2FOP|rcsb pdb:2KVR|rcsb pdb:2XXN|rcsb pdb:2YLM|rcsb pdb:3MQR|rcsb pdb:3MQS|rcsb pdb:4JJQ|rcsb pdb:4KG9|rcsb pdb:4M5W|go:"GO:0006283"(transcription-coupled nucleotide-excision repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010216"(maintenance of DNA methylation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035520"(monoubiquitinated protein deubiquitination)|go:"GO:0035616"(histone H2B conserved C-terminal lysine deubiquitination)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0048511"(rhythmic process)|go:"GO:0050821"(protein stabilization)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0101005"(deubiquitinase activity)|go:"GO:1901537"(positive regulation of DNA demethylation)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1904353"(regulation of telomere capping)|go:"GO:1905279"(regulation of retrograde transport, endosome to Golgi)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR018200|interpro:IPR024729|interpro:IPR028889|ensembl:ENSG00000187555(gene)|ensembl:ENST00000344836(transcript)|go:"GO:0002039"(p53 binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0006111"(regulation of gluconeogenesis)|rcsb pdb:5N9R|rcsb pdb:5N9T|rcsb pdb:5NGE|rcsb pdb:5NGF|rcsb pdb:5UQV|rcsb pdb:5UQX|rcsb pdb:5VS6|rcsb pdb:5VSB|rcsb pdb:5VSK|rcsb pdb:5WHC|rcsb pdb:6F5H|rcsb pdb:6M1K|rcsb pdb:6P5L|rcsb pdb:6VN2|rcsb pdb:6VN3|rcsb pdb:6VN4|rcsb pdb:6VN5|rcsb pdb:6VN6|rcsb pdb:7CM2|reactome:R-HSA-5689880|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6804757|reactome:R-HSA-8866652|reactome:R-HSA-8948747|refseq:NP_001273386.1|refseq:NP_003461.2|refseq:NP_001308787.1|ensembl:ENSP00000343535|ensembl:ENST00000381886|ensembl:ENSP00000371310|dip:DIP-29053N refseq:NP_001007794.1|refseq:NP_004716.1|ensembl:ENSG00000154473(gene)|ensembl:ENST00000368865(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000776"(kinetochore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|interpro:IPR020472|interpro:IPR036322|mint:O43684|reactome:R-HSA-141430|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|reactome:R-HSA-141444|reactome:R-HSA-174184|reactome:R-HSA-176409|reactome:R-HSA-179409|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|go:"GO:0008608"(attachment of spindle microtubules to kinetochore)|reactome:R-HSA-68877|reactome:R-HSA-9648025|go:"GO:0033597"(mitotic checkpoint complex)|go:"GO:0034501"(protein localization to kinetochore)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0051301"(cell division)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:1990298"(bub1-bub3 complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|dip:DIP-24205N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:V+PXXBRM2zwlGQaeFiyjaQ9yf+A9606 rogid:nqzARPql2cThSUpxSb6PuTRn51E9606 intact-crc:0247E0A3D2DA0BA0|rigid:YNzZdLlQUWY3+HOVHH44/ctr6C4 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96JH7 uniprotkb:Q7Z6Z7 intact:EBI-1995920|uniprotkb:Q504T4|uniprotkb:Q86T93|uniprotkb:Q86W01|uniprotkb:Q8N3A9|uniprotkb:Q9H5R8|ensembl:ENSP00000309031 intact:EBI-625934|uniprotkb:O15029|uniprotkb:Q4G2Z2|uniprotkb:Q5H961|uniprotkb:Q6P4D0|uniprotkb:Q8NG67|uniprotkb:Q9BUI0|uniprotkb:Q9HCJ4|uniprotkb:Q9NSL6|uniprotkb:Q9P0A9|ensembl:ENSP00000262854|ensembl:ENSP00000340648 psi-mi:vcip1_human(display_long)|uniprotkb:VCPIP1(gene name)|psi-mi:VCPIP1(display_short)|uniprotkb:KIAA1850(gene name synonym)|uniprotkb:VCIP135(gene name synonym)|uniprotkb:Valosin-containing protein p97/p47 complex-interacting protein p135(gene name synonym)|uniprotkb:Valosin-containing protein p97/p47 complex-interacting protein 1(gene name synonym) psi-mi:huwe1_human(display_long)|uniprotkb:HECT, UBA and WWE domain-containing protein 1(gene name synonym)|uniprotkb:Upstream regulatory element-binding protein 1(gene name synonym)|uniprotkb:Mcl-1 ubiquitin ligase E3(gene name synonym)|uniprotkb:ARF-binding protein 1(gene name synonym)|uniprotkb:Large structure of UREB1(gene name synonym)|uniprotkb:Homologous to E6AP carboxyl terminus homologous protein 9(gene name synonym)|uniprotkb:HUWE1(gene name)|psi-mi:HUWE1(display_short)|uniprotkb:KIAA0312(gene name synonym)|uniprotkb:KIAA1578(gene name synonym)|uniprotkb:HSPC272(orf name)|uniprotkb:HECT-type E3 ubiquitin transferase HUWE1(gene name synonym)|uniprotkb:UREB1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513235|imex:IM-12079-29 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_079330.2|ensembl:ENSG00000175073(gene)|ensembl:ENST00000310421(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005795"(Golgi stack)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016320"(endoplasmic reticulum membrane fusion)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035871"(protein K11-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:0090168"(Golgi reassembly)|go:"GO:0106300"(protein-DNA covalent cross-linking repair)|go:"GO:1905634"(regulation of protein localization to chromatin)|interpro:IPR003323(Ovarian tumour, otubain)|interpro:IPR029071|interpro:IPR039087|mint:Q96JH7|reactome:R-HSA-5689896 ensembl:ENSG00000086758(gene)|ensembl:ENST00000262854(transcript)|ensembl:ENST00000342160(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006284"(base-excision repair)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0007030"(Golgi organization)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0030154"(cell differentiation)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000569(HECT)|interpro:IPR004170(WWE)|interpro:IPR009060(UBA-like)|interpro:IPR010309(E3 ubiquitin ligase, region of unknown function DUF908)|interpro:IPR010314(E3 ubiquitin ligase, region of unknown function DUF913)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR025527|interpro:IPR035983|interpro:IPR037197|interpro:IPR041918|mint:Q7Z6Z7|rcsb pdb:2EKK|rcsb pdb:2MUL|rcsb pdb:3G1N|go:"GO:0061025"(membrane fusion)|rcsb pdb:5C6H|rcsb pdb:5LP8|rcsb pdb:6FYH|rcsb pdb:6MIW|rcsb pdb:6PFL|reactome:R-HSA-6798695|rcsb pdb:3H1D|reactome:R-HSA-983168|refseq:NP_113584.3|refseq:XP_005262022.1|dip:DIP-34362N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:EMqKXIMqv42Vlg5oUS+kT9WI5BQ9606 rogid:TnIn0mcFc81bJlMkyWTtq3n/uOg9606 intact-crc:58FBC716FBD36C36|rigid:IyopvZW+TabQ7diMfbKPjkG1nc0 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96JH7 uniprotkb:Q96CS3 intact:EBI-1995920|uniprotkb:Q504T4|uniprotkb:Q86T93|uniprotkb:Q86W01|uniprotkb:Q8N3A9|uniprotkb:Q9H5R8|ensembl:ENSP00000309031 intact:EBI-1055805|uniprotkb:O94963|uniprotkb:Q8IUF2|uniprotkb:Q9BRP2|uniprotkb:Q9BVM7|ensembl:ENSP00000261942 psi-mi:vcip1_human(display_long)|uniprotkb:VCPIP1(gene name)|psi-mi:VCPIP1(display_short)|uniprotkb:KIAA1850(gene name synonym)|uniprotkb:VCIP135(gene name synonym)|uniprotkb:Valosin-containing protein p97/p47 complex-interacting protein p135(gene name synonym)|uniprotkb:Valosin-containing protein p97/p47 complex-interacting protein 1(gene name synonym) psi-mi:faf2_human(display_long)|uniprotkb:Protein ETEA(gene name synonym)|uniprotkb:FAF2(gene name)|psi-mi:FAF2(display_short)|uniprotkb:ETEA(gene name synonym)|uniprotkb:KIAA0887(gene name synonym)|uniprotkb:UBXD8(gene name synonym)|uniprotkb:UBXN3B(gene name synonym)|uniprotkb:UBX domain-containing protein 3B(gene name synonym)|uniprotkb:UBX domain-containing protein 8(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513235|imex:IM-12079-29 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_079330.2|ensembl:ENSG00000175073(gene)|ensembl:ENST00000310421(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005795"(Golgi stack)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016320"(endoplasmic reticulum membrane fusion)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035871"(protein K11-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:0090168"(Golgi reassembly)|go:"GO:0106300"(protein-DNA covalent cross-linking repair)|go:"GO:1905634"(regulation of protein localization to chromatin)|interpro:IPR003323(Ovarian tumour, otubain)|interpro:IPR029071|interpro:IPR039087|mint:Q96JH7|reactome:R-HSA-5689896 refseq:NP_055428.1|ensembl:ENSP00000261942|ensembl:ENST00000261942(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005811"(lipid droplet)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034098"(VCP-NPL4-UFD1 AAA ATPase complex)|go:"GO:0034389"(lipid droplet organization)|go:"GO:0035473"(lipase binding)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0055102"(lipase inhibitor activity)|interpro:IPR001012(UBX)|interpro:IPR006577(UAS)|interpro:IPR009060(UBA-like)|interpro:IPR029071|interpro:IPR036249|mint:Q96CS3|rcsb pdb:2DAM|reactome:R-HSA-6798695|reactome:R-HSA-8980692|ensembl:ENSG00000113194(gene)|dip:DIP-46261N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:EMqKXIMqv42Vlg5oUS+kT9WI5BQ9606 rogid:GCm7BqDpwxDW1iABu0cShmWHtZQ9606 intact-crc:58FBC716FBD36C36|rigid:IyopvZW+TabQ7diMfbKPjkG1nc0 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96JH7 uniprotkb:Q14CS0 intact:EBI-1995920|uniprotkb:Q504T4|uniprotkb:Q86T93|uniprotkb:Q86W01|uniprotkb:Q8N3A9|uniprotkb:Q9H5R8|ensembl:ENSP00000309031 intact:EBI-1993619|uniprotkb:B3KWZ3|ensembl:ENSP00000382507 psi-mi:vcip1_human(display_long)|uniprotkb:VCPIP1(gene name)|psi-mi:VCPIP1(display_short)|uniprotkb:KIAA1850(gene name synonym)|uniprotkb:VCIP135(gene name synonym)|uniprotkb:Valosin-containing protein p97/p47 complex-interacting protein p135(gene name synonym)|uniprotkb:Valosin-containing protein p97/p47 complex-interacting protein 1(gene name synonym) psi-mi:ubx2b_human(display_long)|uniprotkb:UBXN2B(gene name)|psi-mi:UBXN2B(display_short)|uniprotkb:NSFL1 cofactor p37(gene name synonym)|uniprotkb:p97 cofactor p37(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513235|imex:IM-12079-29 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_079330.2|ensembl:ENSG00000175073(gene)|ensembl:ENST00000310421(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005795"(Golgi stack)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016320"(endoplasmic reticulum membrane fusion)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035871"(protein K11-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:0090168"(Golgi reassembly)|go:"GO:0106300"(protein-DNA covalent cross-linking repair)|go:"GO:1905634"(regulation of protein localization to chromatin)|interpro:IPR003323(Ovarian tumour, otubain)|interpro:IPR029071|interpro:IPR039087|mint:Q96JH7|reactome:R-HSA-5689896 refseq:NP_001071087.1|refseq:NP_001317464.1|ensembl:ENSG00000215114(gene)|ensembl:ENST00000399598(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0007030"(Golgi organization)|go:"GO:0031468"(nuclear membrane reassembly)|go:"GO:0031616"(spindle pole centrosome)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0046604"(positive regulation of mitotic centrosome separation)|go:"GO:0061025"(membrane fusion)|go:"GO:1904780"(negative regulation of protein localization to centrosome)|interpro:IPR001012(UBX)|interpro:IPR012989(SEP)|interpro:IPR029071|interpro:IPR036241 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:EMqKXIMqv42Vlg5oUS+kT9WI5BQ9606 rogid:tCd/qJLW1wYuC3WTakXevcMRtPU9606 intact-crc:58FBC716FBD36C36|rigid:IyopvZW+TabQ7diMfbKPjkG1nc0 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96JH7 uniprotkb:Q92890 intact:EBI-1995920|uniprotkb:Q504T4|uniprotkb:Q86T93|uniprotkb:Q86W01|uniprotkb:Q8N3A9|uniprotkb:Q9H5R8|ensembl:ENSP00000309031 intact:EBI-1994090|uniprotkb:Q9Y5N0|uniprotkb:A8MW31|ensembl:ENSP00000263202 psi-mi:vcip1_human(display_long)|uniprotkb:VCPIP1(gene name)|psi-mi:VCPIP1(display_short)|uniprotkb:KIAA1850(gene name synonym)|uniprotkb:VCIP135(gene name synonym)|uniprotkb:Valosin-containing protein p97/p47 complex-interacting protein p135(gene name synonym)|uniprotkb:Valosin-containing protein p97/p47 complex-interacting protein 1(gene name synonym) psi-mi:ufd1_human(display_long)|uniprotkb:UFD1(gene name)|psi-mi:UFD1(display_short)|uniprotkb:UFD1L(gene name synonym)|uniprotkb:Ubiquitin fusion degradation protein 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513235|imex:IM-12079-29 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_079330.2|ensembl:ENSG00000175073(gene)|ensembl:ENST00000310421(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005795"(Golgi stack)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016320"(endoplasmic reticulum membrane fusion)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035871"(protein K11-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:0090168"(Golgi reassembly)|go:"GO:0106300"(protein-DNA covalent cross-linking repair)|go:"GO:1905634"(regulation of protein localization to chromatin)|interpro:IPR003323(Ovarian tumour, otubain)|interpro:IPR029071|interpro:IPR039087|mint:Q96JH7|reactome:R-HSA-5689896 refseq:NP_005650.2|refseq:NP_001030324.2|dip:DIP-45954N|ensembl:ENSG00000070010(gene)|ensembl:ENST00000263202(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0032480"(negative regulation of type I interferon production)|go:"GO:0034098"(VCP-NPL4-UFD1 AAA ATPase complex)|go:"GO:0036435"(K48-linked polyubiquitin modification-dependent protein binding)|go:"GO:0036501"(UFD1-NPL4 complex)|go:"GO:0039536"(negative regulation of RIG-I signaling pathway)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0071712"(ER-associated misfolded protein catabolic process)|interpro:IPR004854(Ubiquitin fusion degradation protein UFD1)|interpro:IPR042299|mint:Q92890|rcsb pdb:2YUJ|rcsb pdb:5B6C|rcsb pdb:5C1B|reactome:R-HSA-110320|reactome:R-HSA-5689880|go:"GO:0031593"(polyubiquitin modification-dependent protein binding) psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:EMqKXIMqv42Vlg5oUS+kT9WI5BQ9606 rogid:TD7xj2n1cP5JexKMoVg1JfTQArI9606 intact-crc:58FBC716FBD36C36|rigid:IyopvZW+TabQ7diMfbKPjkG1nc0 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96JH7 uniprotkb:Q9NXW1 intact:EBI-1995920|uniprotkb:Q504T4|uniprotkb:Q86T93|uniprotkb:Q86W01|uniprotkb:Q8N3A9|uniprotkb:Q9H5R8|ensembl:ENSP00000309031 intact:EBI-2513228 psi-mi:vcip1_human(display_long)|uniprotkb:VCPIP1(gene name)|psi-mi:VCPIP1(display_short)|uniprotkb:KIAA1850(gene name synonym)|uniprotkb:VCIP135(gene name synonym)|uniprotkb:Valosin-containing protein p97/p47 complex-interacting protein p135(gene name synonym)|uniprotkb:Valosin-containing protein p97/p47 complex-interacting protein 1(gene name synonym) psi-mi:q9nxw1_human(display_long) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513235|imex:IM-12079-29 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_079330.2|ensembl:ENSG00000175073(gene)|ensembl:ENST00000310421(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005795"(Golgi stack)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016320"(endoplasmic reticulum membrane fusion)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035871"(protein K11-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:0090168"(Golgi reassembly)|go:"GO:0106300"(protein-DNA covalent cross-linking repair)|go:"GO:1905634"(regulation of protein localization to chromatin)|interpro:IPR003323(Ovarian tumour, otubain)|interpro:IPR029071|interpro:IPR039087|mint:Q96JH7|reactome:R-HSA-5689896 go:"GO:0016021"(integral component of membrane)|interpro:IPR010309(E3 ubiquitin ligase, region of unknown function DUF908)|interpro:IPR011057(Mss4-like)|interpro:IPR018103|interpro:IPR018105|interpro:IPR034737|interpro:IPR016024(Armadillo-type fold)|interpro:IPR011323(Mss4/translationally controlled tumour-associated TCTP) psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:EMqKXIMqv42Vlg5oUS+kT9WI5BQ9606 rogid:P+SVhnDb/d2cy5LjYdtGDHPNKRE9606 intact-crc:58FBC716FBD36C36|rigid:IyopvZW+TabQ7diMfbKPjkG1nc0 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96JH7 uniprotkb:Q96J65 intact:EBI-1995920|uniprotkb:Q504T4|uniprotkb:Q86T93|uniprotkb:Q86W01|uniprotkb:Q8N3A9|uniprotkb:Q9H5R8|ensembl:ENSP00000309031 intact:EBI-2513220|ensembl:ENSP00000311030|uniprotkb:Q8TEY2|uniprotkb:Q8TAF0|uniprotkb:Q49AL2 psi-mi:vcip1_human(display_long)|uniprotkb:VCPIP1(gene name)|psi-mi:VCPIP1(display_short)|uniprotkb:KIAA1850(gene name synonym)|uniprotkb:VCIP135(gene name synonym)|uniprotkb:Valosin-containing protein p97/p47 complex-interacting protein p135(gene name synonym)|uniprotkb:Valosin-containing protein p97/p47 complex-interacting protein 1(gene name synonym) psi-mi:mrp9_human(display_long)|uniprotkb:ABCC12(gene name)|psi-mi:ABCC12(display_short)|uniprotkb:MRP9(gene name synonym)|uniprotkb:Multidrug resistance-associated protein 9(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513235|imex:IM-12079-29 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_079330.2|ensembl:ENSG00000175073(gene)|ensembl:ENST00000310421(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005795"(Golgi stack)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016320"(endoplasmic reticulum membrane fusion)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035871"(protein K11-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:0090168"(Golgi reassembly)|go:"GO:0106300"(protein-DNA covalent cross-linking repair)|go:"GO:1905634"(regulation of protein localization to chromatin)|interpro:IPR003323(Ovarian tumour, otubain)|interpro:IPR029071|interpro:IPR039087|mint:Q96JH7|reactome:R-HSA-5689896 ensembl:ENSG00000140798(gene)|ensembl:ENST00000311303(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042626"(ATPase-coupled transmembrane transporter activity)|go:"GO:0055085"(transmembrane transport)|interpro:IPR003439(ABC transporter-like)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR011527(ABC transporter, transmembrane region, type 1)|interpro:IPR017871|interpro:IPR027417|interpro:IPR030250|interpro:IPR036640|refseq:NP_150229.2 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:EMqKXIMqv42Vlg5oUS+kT9WI5BQ9606 rogid:i4QBB9iMRQurMefF14hTwrgGvxc9606 intact-crc:58FBC716FBD36C36|rigid:IyopvZW+TabQ7diMfbKPjkG1nc0 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96JH7 uniprotkb:P68543 intact:EBI-1995920|uniprotkb:Q504T4|uniprotkb:Q86T93|uniprotkb:Q86W01|uniprotkb:Q8N3A9|uniprotkb:Q9H5R8|ensembl:ENSP00000309031 intact:EBI-1993668|uniprotkb:Q569G8|uniprotkb:A8K577|uniprotkb:B7ZKP8|intact:EBI-11054048|ensembl:ENSP00000312107|ensembl:ENSP00000385525 psi-mi:vcip1_human(display_long)|uniprotkb:VCPIP1(gene name)|psi-mi:VCPIP1(display_short)|uniprotkb:KIAA1850(gene name synonym)|uniprotkb:VCIP135(gene name synonym)|uniprotkb:Valosin-containing protein p97/p47 complex-interacting protein p135(gene name synonym)|uniprotkb:Valosin-containing protein p97/p47 complex-interacting protein 1(gene name synonym) psi-mi:ubx2a_human(display_long)|uniprotkb:UBXN2A(gene name)|psi-mi:UBXN2A(display_short)|uniprotkb:UBXD4(gene name synonym)|uniprotkb:UBX domain-containing protein 4(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513235|imex:IM-12079-29 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_079330.2|ensembl:ENSG00000175073(gene)|ensembl:ENST00000310421(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005795"(Golgi stack)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016320"(endoplasmic reticulum membrane fusion)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035871"(protein K11-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:0090168"(Golgi reassembly)|go:"GO:0106300"(protein-DNA covalent cross-linking repair)|go:"GO:1905634"(regulation of protein localization to chromatin)|interpro:IPR003323(Ovarian tumour, otubain)|interpro:IPR029071|interpro:IPR039087|mint:Q96JH7|reactome:R-HSA-5689896 refseq:XP_011530935.1|refseq:NP_859064.2|refseq:XP_005264223.1|refseq:XP_005264224.1|refseq:XP_005264225.1|refseq:XP_005264226.1|ensembl:ENSG00000173960(gene)|ensembl:ENST00000309033(transcript)|ensembl:ENST00000404924(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0007030"(Golgi organization)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0031396"(regulation of protein ubiquitination)|go:"GO:0031468"(nuclear membrane reassembly)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0061025"(membrane fusion)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR001012(UBX)|interpro:IPR012989(SEP)|interpro:IPR029071|interpro:IPR036241 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:EMqKXIMqv42Vlg5oUS+kT9WI5BQ9606 rogid:NajxPLxqkVsb8f+ID6D9VRv+gR89606 intact-crc:58FBC716FBD36C36|rigid:IyopvZW+TabQ7diMfbKPjkG1nc0 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96JH7 uniprotkb:Q8TAT6 intact:EBI-1995920|uniprotkb:Q504T4|uniprotkb:Q86T93|uniprotkb:Q86W01|uniprotkb:Q8N3A9|uniprotkb:Q9H5R8|ensembl:ENSP00000309031 intact:EBI-1994109|uniprotkb:Q8N3J1|uniprotkb:Q9H8V2|uniprotkb:Q9H964|uniprotkb:Q9NWR5|uniprotkb:Q9P229|ensembl:ENSP00000331487 psi-mi:vcip1_human(display_long)|uniprotkb:VCPIP1(gene name)|psi-mi:VCPIP1(display_short)|uniprotkb:KIAA1850(gene name synonym)|uniprotkb:VCIP135(gene name synonym)|uniprotkb:Valosin-containing protein p97/p47 complex-interacting protein p135(gene name synonym)|uniprotkb:Valosin-containing protein p97/p47 complex-interacting protein 1(gene name synonym) psi-mi:npl4_human(display_long)|uniprotkb:NPLOC4(gene name)|psi-mi:NPLOC4(display_short)|uniprotkb:KIAA1499(gene name synonym)|uniprotkb:NPL4(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513235|imex:IM-12079-29 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_079330.2|ensembl:ENSG00000175073(gene)|ensembl:ENST00000310421(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005795"(Golgi stack)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016320"(endoplasmic reticulum membrane fusion)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035871"(protein K11-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:0090168"(Golgi reassembly)|go:"GO:0106300"(protein-DNA covalent cross-linking repair)|go:"GO:1905634"(regulation of protein localization to chromatin)|interpro:IPR003323(Ovarian tumour, otubain)|interpro:IPR029071|interpro:IPR039087|mint:Q96JH7|reactome:R-HSA-5689896 refseq:XP_011523281.1|refseq:NP_060391.2|dip:DIP-44059N|ensembl:ENSG00000182446(gene)|ensembl:ENST00000331134(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007030"(Golgi organization)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032480"(negative regulation of type I interferon production)|go:"GO:0034098"(VCP-NPL4-UFD1 AAA ATPase complex)|go:"GO:0036501"(UFD1-NPL4 complex)|go:"GO:0039536"(negative regulation of RIG-I signaling pathway)|go:"GO:0042175"(nuclear outer membrane-endoplasmic reticulum membrane network)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR007716(NPL4, zinc-binding putative)|interpro:IPR007717(NPL4)|interpro:IPR016563(Polyubiquitin-tagged protein recognition complex, Npl4 component)|interpro:IPR024682|interpro:IPR029071|interpro:IPR036443|interpro:IPR037518|mint:Q8TAT6|reactome:R-HSA-110320 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:EMqKXIMqv42Vlg5oUS+kT9WI5BQ9606 rogid:GXRNmG7yqEf5aFMo7yPDih93yfk9606 intact-crc:58FBC716FBD36C36|rigid:IyopvZW+TabQ7diMfbKPjkG1nc0 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96JH7 uniprotkb:Q8NHG7 intact:EBI-1995920|uniprotkb:Q504T4|uniprotkb:Q86T93|uniprotkb:Q86W01|uniprotkb:Q8N3A9|uniprotkb:Q9H5R8|ensembl:ENSP00000309031 intact:EBI-2513231|ensembl:ENSP00000346130 psi-mi:vcip1_human(display_long)|uniprotkb:VCPIP1(gene name)|psi-mi:VCPIP1(display_short)|uniprotkb:KIAA1850(gene name synonym)|uniprotkb:VCIP135(gene name synonym)|uniprotkb:Valosin-containing protein p97/p47 complex-interacting protein p135(gene name synonym)|uniprotkb:Valosin-containing protein p97/p47 complex-interacting protein 1(gene name synonym) psi-mi:svip_human(display_long)|uniprotkb:SVIP(gene name)|psi-mi:SVIP(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513235|imex:IM-12079-29 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_079330.2|ensembl:ENSG00000175073(gene)|ensembl:ENST00000310421(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005795"(Golgi stack)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016320"(endoplasmic reticulum membrane fusion)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035871"(protein K11-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:0090168"(Golgi reassembly)|go:"GO:0106300"(protein-DNA covalent cross-linking repair)|go:"GO:1905634"(regulation of protein localization to chromatin)|interpro:IPR003323(Ovarian tumour, otubain)|interpro:IPR029071|interpro:IPR039087|mint:Q96JH7|reactome:R-HSA-5689896 ensembl:ENSG00000198168(gene)|ensembl:ENST00000354193(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0030667"(secretory granule membrane)|go:"GO:0030868"(smooth endoplasmic reticulum membrane)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0043621"(protein self-association)|go:"GO:0051117"(ATPase binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:1903061"(positive regulation of protein lipidation)|go:"GO:1903070"(negative regulation of ER-associated ubiquitin-dependent protein catabolic process)|go:"GO:1904153"(negative regulation of retrograde protein transport, ER to cytosol)|go:"GO:1904240"(negative regulation of VCP-NPL4-UFD1 AAA ATPase complex assembly)|interpro:IPR031632|reactome:R-HSA-6798695|refseq:NP_683691.1|refseq:NP_001307269.1|refseq:NP_001307271.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:EMqKXIMqv42Vlg5oUS+kT9WI5BQ9606 rogid:FR4SJrjkMKdfe5RvI6BKgP2rOQo9606 intact-crc:58FBC716FBD36C36|rigid:IyopvZW+TabQ7diMfbKPjkG1nc0 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96JH7 uniprotkb:P55072 intact:EBI-1995920|uniprotkb:Q504T4|uniprotkb:Q86T93|uniprotkb:Q86W01|uniprotkb:Q8N3A9|uniprotkb:Q9H5R8|ensembl:ENSP00000309031 intact:EBI-355164|uniprotkb:Q969G7|uniprotkb:Q9UCD5|uniprotkb:B2R5T8|uniprotkb:Q0V924|uniprotkb:Q2TAI5|intact:EBI-1046421|ensembl:ENSP00000351777 psi-mi:vcip1_human(display_long)|uniprotkb:VCPIP1(gene name)|psi-mi:VCPIP1(display_short)|uniprotkb:KIAA1850(gene name synonym)|uniprotkb:VCIP135(gene name synonym)|uniprotkb:Valosin-containing protein p97/p47 complex-interacting protein p135(gene name synonym)|uniprotkb:Valosin-containing protein p97/p47 complex-interacting protein 1(gene name synonym) psi-mi:tera_human(display_long)|uniprotkb:VCP(gene name)|psi-mi:VCP(display_short)|uniprotkb:"15S Mg(2+)-ATPase p97 subunit"(gene name synonym)|uniprotkb:Valosin-containing protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513235|imex:IM-12079-29 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_079330.2|ensembl:ENSG00000175073(gene)|ensembl:ENST00000310421(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005795"(Golgi stack)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016320"(endoplasmic reticulum membrane fusion)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035871"(protein K11-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:0090168"(Golgi reassembly)|go:"GO:0106300"(protein-DNA covalent cross-linking repair)|go:"GO:1905634"(regulation of protein localization to chromatin)|interpro:IPR003323(Ovarian tumour, otubain)|interpro:IPR029071|interpro:IPR039087|mint:Q96JH7|reactome:R-HSA-5689896 refseq:NP_009057.1|rcsb pdb:7BPA|rcsb pdb:7BPB|rcsb pdb:7JY5|reactome:R-HSA-110320|reactome:R-HSA-3371511|reactome:R-HSA-382556|reactome:R-HSA-532668|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5678895|reactome:R-HSA-5689877|reactome:R-HSA-5689896|reactome:R-HSA-6798695|reactome:R-HSA-8866654|reactome:R-HSA-8876725|reactome:R-HSA-9013407|reactome:R-HSA-9646399|reactome:R-HSA-9678110|reactome:R-HSA-9694614|rcsb pdb:7BP9|go:"GO:0032510"(endosome to lysosome transport via multivesicular body sorting pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034098"(VCP-NPL4-UFD1 AAA ATPase complex)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0035617"(stress granule disassembly)|go:"GO:0035800"(deubiquitinase activator activity)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0036435"(K48-linked polyubiquitin modification-dependent protein binding)|go:"GO:0036503"(ERAD pathway)|go:"GO:0036513"(Derlin-1 retrotranslocation complex)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043531"(ADP binding)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0051228"(mitotic spindle disassembly)|go:"GO:0061857"(endoplasmic reticulum stress-induced pre-emptive quality control)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070842"(aggresome assembly)|go:"GO:0071712"(ER-associated misfolded protein catabolic process)|go:"GO:0072389"(flavin adenine dinucleotide catabolic process)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097352"(autophagosome maturation)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106300"(protein-DNA covalent cross-linking repair)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1903006"(positive regulation of protein K63-linked deubiquitination)|go:"GO:1903007"(positive regulation of Lys63-specific deubiquitinase activity)|go:"GO:1903715"(regulation of aerobic respiration)|go:"GO:1903843"(cellular response to arsenite ion)|go:"GO:1903862"(positive regulation of oxidative phosphorylation)|go:"GO:1904288"(BAT3 complex binding)|go:"GO:1904813"(ficolin-1-rich granule lumen)|go:"GO:1904949"(ATPase complex)|go:"GO:1905634"(regulation of protein localization to chromatin)|go:"GO:1990381"(ubiquitin-specific protease binding)|go:"GO:1990730"(VCP-NSFL1C complex)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|interpro:IPR003338(AAA ATPase VAT, N-terminal)|interpro:IPR003593(AAA+ ATPase, core)|ensembl:ENSG00000165280(gene)|ensembl:ENST00000358901(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006734"(NADH metabolic process)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006914"(autophagy)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008289"(lipid binding)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0010918"(positive regulation of mitochondrial membrane potential)|go:"GO:0016236"(macroautophagy)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019079"(viral genome replication)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0019985"(translesion synthesis)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR004201(Cell division protein 48, CDC48, domain 2)|interpro:IPR005938(AAA ATPase, CDC48)|interpro:IPR009010(Aspartate decarboxylase-like fold)|interpro:IPR015415(Vps4 oligomerisation, C-terminal)|interpro:IPR027417|interpro:IPR029067|interpro:IPR041569|mint:P55072|rcsb pdb:3EBB|rcsb pdb:3HU1|rcsb pdb:3HU2|rcsb pdb:3HU3|rcsb pdb:3QC8|rcsb pdb:3QQ7|rcsb pdb:3QQ8|rcsb pdb:3QWZ|rcsb pdb:3TIW|rcsb pdb:4KDI|rcsb pdb:4KDL|rcsb pdb:4KLN|rcsb pdb:4KO8|rcsb pdb:4KOD|rcsb pdb:4P0A|rcsb pdb:5B6C|rcsb pdb:5C18|rcsb pdb:5C19|rcsb pdb:5C1A|rcsb pdb:5C1B|rcsb pdb:5DYG|rcsb pdb:5DYI|rcsb pdb:5EPP|rcsb pdb:5FTJ|rcsb pdb:5FTK|rcsb pdb:5FTL|rcsb pdb:5FTM|rcsb pdb:5FTN|rcsb pdb:5GLF|rcsb pdb:5IFS|rcsb pdb:5IFW|rcsb pdb:5KIW|rcsb pdb:5KIY|rcsb pdb:5X4L|rcsb pdb:6G2V|rcsb pdb:6G2W|rcsb pdb:6G2X|rcsb pdb:6G2Y|rcsb pdb:6G2Z|rcsb pdb:6G30|rcsb pdb:6HD0|rcsb pdb:6MCK|rcsb pdb:7BP8|dip:DIP-33543N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:EMqKXIMqv42Vlg5oUS+kT9WI5BQ9606 rogid:HrjDhdsDcgaf8HEbqqMjUqxPaEs9606 intact-crc:58FBC716FBD36C36|rigid:IyopvZW+TabQ7diMfbKPjkG1nc0 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96JH7 uniprotkb:Q9UNZ2 intact:EBI-1995920|uniprotkb:Q504T4|uniprotkb:Q86T93|uniprotkb:Q86W01|uniprotkb:Q8N3A9|uniprotkb:Q9H5R8|ensembl:ENSP00000309031 intact:EBI-721577|uniprotkb:Q7Z533|uniprotkb:Q9H102|uniprotkb:Q9NVL9|uniprotkb:Q9UI06|uniprotkb:Q5JXA5|uniprotkb:B2RD74|uniprotkb:Q5JXA4|uniprotkb:A2A2L1|ensembl:ENSP00000216879 psi-mi:vcip1_human(display_long)|uniprotkb:VCPIP1(gene name)|psi-mi:VCPIP1(display_short)|uniprotkb:KIAA1850(gene name synonym)|uniprotkb:VCIP135(gene name synonym)|uniprotkb:Valosin-containing protein p97/p47 complex-interacting protein p135(gene name synonym)|uniprotkb:Valosin-containing protein p97/p47 complex-interacting protein 1(gene name synonym) psi-mi:nsf1c_human(display_long)|uniprotkb:p97 cofactor p47(gene name synonym)|uniprotkb:NSFL1C(gene name)|psi-mi:NSFL1C(display_short)|uniprotkb:UBXN2C(gene name synonym)|uniprotkb:UBX domain-containing protein 2C(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513235|imex:IM-12079-29 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_079330.2|ensembl:ENSG00000175073(gene)|ensembl:ENST00000310421(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005795"(Golgi stack)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016320"(endoplasmic reticulum membrane fusion)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035871"(protein K11-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:0090168"(Golgi reassembly)|go:"GO:0106300"(protein-DNA covalent cross-linking repair)|go:"GO:1905634"(regulation of protein localization to chromatin)|interpro:IPR003323(Ovarian tumour, otubain)|interpro:IPR029071|interpro:IPR039087|mint:Q96JH7|reactome:R-HSA-5689896 refseq:NP_001193665.1|refseq:NP_057227.2|refseq:NP_061327.2|dip:DIP-39611N|refseq:XP_006723657.1|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005795"(Golgi stack)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007030"(Golgi organization)|go:"GO:0031468"(nuclear membrane reassembly)|go:"GO:0031616"(spindle pole centrosome)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0046604"(positive regulation of mitotic centrosome separation)|go:"GO:0051117"(ATPase binding)|go:"GO:0061025"(membrane fusion)|go:"GO:1904780"(negative regulation of protein localization to centrosome)|go:"GO:1990730"(VCP-NSFL1C complex)|interpro:IPR001012(UBX)|interpro:IPR009060(UBA-like)|interpro:IPR012989(SEP)|interpro:IPR029071|interpro:IPR036241|mint:Q9UNZ2|rcsb pdb:1SS6|reactome:R-HSA-9013407|go:"GO:0000045"(autophagosome assembly)|ensembl:ENSG00000088833(gene)|ensembl:ENST00000216879(transcript) psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:EMqKXIMqv42Vlg5oUS+kT9WI5BQ9606 rogid:LhK56TmbnfHvffJ2WUFlJJepje89606 intact-crc:58FBC716FBD36C36|rigid:IyopvZW+TabQ7diMfbKPjkG1nc0 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q6R6M4 uniprotkb:Q0WX57 intact:EBI-2511810|ensembl:ENSP00000333329 intact:EBI-2511781|ensembl:ENSP00000422097|ensembl:ENSP00000422887|ensembl:ENSP00000422969|ensembl:ENSP00000423211|ensembl:ENSP00000423777|ensembl:ENSP00000425375|ensembl:ENSP00000427366|uniprotkb:Q0WX56|uniprotkb:A8MRA9|uniprotkb:Q3BEM1 psi-mi:u17l2_human(display_long)|uniprotkb:USP17L2(gene name)|psi-mi:USP17L2(display_short)|uniprotkb:DUB3(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 17-like protein 2(gene name synonym)|uniprotkb:Deubiquitinating enzyme 17-like protein 2(gene name synonym)|uniprotkb:Deubiquitinating protein 3(gene name synonym)|uniprotkb:USP17(gene name synonym)|uniprotkb:USP17H(gene name synonym)|uniprotkb:USP17I(gene name synonym)|uniprotkb:USP17J(gene name synonym)|uniprotkb:USP17K(gene name synonym)|uniprotkb:USP17L(gene name synonym)|uniprotkb:USP17M(gene name synonym)|uniprotkb:Ubiquitin carboxyl-terminal hydrolase 17-like protein 2(gene name synonym)|uniprotkb:Ubiquitin thioesterase 17-like protein 2(gene name synonym) psi-mi:u17lo_human(display_long)|uniprotkb:USP17(gene name synonym)|uniprotkb:USP17L24(gene name)|psi-mi:USP17L24(display_short)|uniprotkb:USP17L25(gene name)|psi-mi:USP17L25(display_short)|uniprotkb:USP17L26(gene name)|psi-mi:USP17L26(display_short)|uniprotkb:USP17L27(gene name)|psi-mi:USP17L27(display_short)|uniprotkb:USP17L28(gene name)|psi-mi:USP17L28(display_short)|uniprotkb:USP17L29(gene name)|psi-mi:USP17L29(display_short)|uniprotkb:USP17L30(gene name)|psi-mi:USP17L30(display_short)|uniprotkb:Deubiquitinating enzyme 17(gene name synonym)|uniprotkb:USP17H(gene name synonym)|uniprotkb:USP17I(gene name synonym)|uniprotkb:USP17J(gene name synonym)|uniprotkb:USP17K(gene name synonym)|uniprotkb:USP17L(gene name synonym)|uniprotkb:USP17M(gene name synonym)|uniprotkb:Ubiquitin thioesterase 17(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 17(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513265|imex:IM-12079-78 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000223443(gene)|ensembl:ENST00000333796(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0010955"(negative regulation of protein processing)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0031064"(negative regulation of histone deacetylation)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0050691"(regulation of defense response to virus by host)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:0071586"(CAAX-box protein processing)|go:"GO:0110030"(regulation of G2/MI transition of meiotic cell cycle)|go:"GO:1900027"(regulation of ruffle assembly)|go:"GO:1900245"(positive regulation of MDA-5 signaling pathway)|go:"GO:1900246"(positive regulation of RIG-I signaling pathway)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|reactome:R-HSA-5689880|reactome:R-HSA-9648002|go:"GO:0090315"(negative regulation of protein targeting to membrane)|refseq:NP_958804.2 ensembl:ENSG00000228856(gene)|ensembl:ENSG00000229579(gene)|ensembl:ENSG00000230430(gene)|ensembl:ENSG00000231051(gene)|ensembl:ENSG00000231637(gene)|ensembl:ENSG00000232264(gene)|ensembl:ENSG00000235780(gene)|ensembl:ENST00000504104(transcript)|ensembl:ENST00000504481(transcript)|ensembl:ENST00000504543(transcript)|ensembl:ENST00000509271(transcript)|ensembl:ENST00000509660(transcript)|ensembl:ENST00000511681(transcript)|ensembl:ENST00000515574(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005540"(hyaluronic acid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0071947"(protein deubiquitination involved in ubiquitin-dependent protein catabolic process)|go:"GO:1904037"(positive regulation of epithelial cell apoptotic process)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR006861(Hyaluronan/mRNA binding protein)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|reactome:R-HSA-5689880|refseq:NP_001229255.1|refseq:NP_001229256.1|refseq:NP_001229257.1|refseq:NP_001229259.1|refseq:NP_001229260.1|refseq:NP_001229261.1|refseq:NP_001243796.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:ECUDXiuY+fF/Se+hz7Y9ZVX0y/A9606 rogid:W9ID/XWR8RGNrH267F2ooi5zsJ89606 intact-crc:9C8A803C99D7E48A|rigid:nJBInnq8cLkZ1kVDAdmtNJXlLVs false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q6R6M4 uniprotkb:Q01105 intact:EBI-2511810|ensembl:ENSP00000333329 intact:EBI-1053182|uniprotkb:A5A5H4|uniprotkb:Q15541|uniprotkb:Q5VXV1|uniprotkb:Q6FHZ5|intact:EBI-2559610|uniprotkb:A6NGV1|uniprotkb:B4DUE2|intact:EBI-4290953|uniprotkb:Q5VXV2|ensembl:ENSP00000361777 psi-mi:u17l2_human(display_long)|uniprotkb:USP17L2(gene name)|psi-mi:USP17L2(display_short)|uniprotkb:DUB3(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 17-like protein 2(gene name synonym)|uniprotkb:Deubiquitinating enzyme 17-like protein 2(gene name synonym)|uniprotkb:Deubiquitinating protein 3(gene name synonym)|uniprotkb:USP17(gene name synonym)|uniprotkb:USP17H(gene name synonym)|uniprotkb:USP17I(gene name synonym)|uniprotkb:USP17J(gene name synonym)|uniprotkb:USP17K(gene name synonym)|uniprotkb:USP17L(gene name synonym)|uniprotkb:USP17M(gene name synonym)|uniprotkb:Ubiquitin carboxyl-terminal hydrolase 17-like protein 2(gene name synonym)|uniprotkb:Ubiquitin thioesterase 17-like protein 2(gene name synonym) psi-mi:set_human(display_long)|uniprotkb:Phosphatase 2A inhibitor I2PP2A(gene name synonym)|uniprotkb:Template-activating factor I(gene name synonym)|uniprotkb:HLA-DR-associated protein II(gene name synonym)|uniprotkb:PHAPII(gene name synonym)|uniprotkb:Inhibitor of granzyme A-activated DNase(gene name synonym)|uniprotkb:SET(gene name)|psi-mi:SET(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513265|imex:IM-12079-78 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000223443(gene)|ensembl:ENST00000333796(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0010955"(negative regulation of protein processing)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0031064"(negative regulation of histone deacetylation)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0050691"(regulation of defense response to virus by host)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:0071586"(CAAX-box protein processing)|go:"GO:0110030"(regulation of G2/MI transition of meiotic cell cycle)|go:"GO:1900027"(regulation of ruffle assembly)|go:"GO:1900245"(positive regulation of MDA-5 signaling pathway)|go:"GO:1900246"(positive regulation of RIG-I signaling pathway)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|reactome:R-HSA-5689880|reactome:R-HSA-9648002|go:"GO:0090315"(negative regulation of protein targeting to membrane)|refseq:NP_958804.2 refseq:NP_001116293.1|refseq:NP_003002.2|dip:DIP-33561N|refseq:NP_001234930.1|refseq:NP_001234929.1|ensembl:ENSG00000119335(gene)|ensembl:ENST00000372692(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0004864"(protein phosphatase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006337"(nucleosome disassembly)|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042393"(histone binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|interpro:IPR002164("Nucleosome assembly protein (NAP)")|interpro:IPR037231|mint:Q01105|rcsb pdb:2E50|rcsb pdb:7MTO|reactome:R-HSA-2299718|reactome:R-HSA-450520|go:"GO:0035067"(negative regulation of histone acetylation) psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:ECUDXiuY+fF/Se+hz7Y9ZVX0y/A9606 rogid:CBwf28rN/LSY/vhw7jxRHKP8q0k9606 intact-crc:9C8A803C99D7E48A|rigid:nJBInnq8cLkZ1kVDAdmtNJXlLVs false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q6R6M4 uniprotkb:P0C7H9 intact:EBI-2511810|ensembl:ENSP00000333329 intact:EBI-2511777|ensembl:ENSP00000485337 psi-mi:u17l2_human(display_long)|uniprotkb:USP17L2(gene name)|psi-mi:USP17L2(display_short)|uniprotkb:DUB3(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 17-like protein 2(gene name synonym)|uniprotkb:Deubiquitinating enzyme 17-like protein 2(gene name synonym)|uniprotkb:Deubiquitinating protein 3(gene name synonym)|uniprotkb:USP17(gene name synonym)|uniprotkb:USP17H(gene name synonym)|uniprotkb:USP17I(gene name synonym)|uniprotkb:USP17J(gene name synonym)|uniprotkb:USP17K(gene name synonym)|uniprotkb:USP17L(gene name synonym)|uniprotkb:USP17M(gene name synonym)|uniprotkb:Ubiquitin carboxyl-terminal hydrolase 17-like protein 2(gene name synonym)|uniprotkb:Ubiquitin thioesterase 17-like protein 2(gene name synonym) psi-mi:u17l7_human(display_long)|uniprotkb:USP17L7(gene name)|psi-mi:USP17L7(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513265|imex:IM-12079-78 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000223443(gene)|ensembl:ENST00000333796(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0010955"(negative regulation of protein processing)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0031064"(negative regulation of histone deacetylation)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0050691"(regulation of defense response to virus by host)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:0071586"(CAAX-box protein processing)|go:"GO:0110030"(regulation of G2/MI transition of meiotic cell cycle)|go:"GO:1900027"(regulation of ruffle assembly)|go:"GO:1900245"(positive regulation of MDA-5 signaling pathway)|go:"GO:1900246"(positive regulation of RIG-I signaling pathway)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|reactome:R-HSA-5689880|reactome:R-HSA-9648002|go:"GO:0090315"(negative regulation of protein targeting to membrane)|refseq:NP_958804.2 ensembl:ENSG00000226430(gene)|ensembl:ENST00000530447(transcript)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0042981"(regulation of apoptotic process)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|refseq:NP_001243798.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:ECUDXiuY+fF/Se+hz7Y9ZVX0y/A9606 rogid:eT+zdD3jiYQz3wkFFcifYzKnREw9606 intact-crc:9C8A803C99D7E48A|rigid:nJBInnq8cLkZ1kVDAdmtNJXlLVs false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q6R6M4 uniprotkb:P83916 intact:EBI-2511810|ensembl:ENSP00000333329 intact:EBI-78129|uniprotkb:P23197|ensembl:ENSP00000225603|ensembl:ENSP00000377060 psi-mi:u17l2_human(display_long)|uniprotkb:USP17L2(gene name)|psi-mi:USP17L2(display_short)|uniprotkb:DUB3(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 17-like protein 2(gene name synonym)|uniprotkb:Deubiquitinating enzyme 17-like protein 2(gene name synonym)|uniprotkb:Deubiquitinating protein 3(gene name synonym)|uniprotkb:USP17(gene name synonym)|uniprotkb:USP17H(gene name synonym)|uniprotkb:USP17I(gene name synonym)|uniprotkb:USP17J(gene name synonym)|uniprotkb:USP17K(gene name synonym)|uniprotkb:USP17L(gene name synonym)|uniprotkb:USP17M(gene name synonym)|uniprotkb:Ubiquitin carboxyl-terminal hydrolase 17-like protein 2(gene name synonym)|uniprotkb:Ubiquitin thioesterase 17-like protein 2(gene name synonym) psi-mi:cbx1_human(display_long)|uniprotkb:CBX1(gene name)|psi-mi:CBX1(display_short)|uniprotkb:CBX(gene name synonym)|uniprotkb:Heterochromatin protein 1 homolog beta(gene name synonym)|uniprotkb:Modifier 1 protein(gene name synonym)|uniprotkb:M31(gene name synonym)|uniprotkb:Heterochromatin protein p25(gene name synonym)|uniprotkb:p25beta(gene name synonym)|uniprotkb:HP1Hsbeta(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513265|imex:IM-12079-78 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000223443(gene)|ensembl:ENST00000333796(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0010955"(negative regulation of protein processing)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0031064"(negative regulation of histone deacetylation)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0050691"(regulation of defense response to virus by host)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:0071586"(CAAX-box protein processing)|go:"GO:0110030"(regulation of G2/MI transition of meiotic cell cycle)|go:"GO:1900027"(regulation of ruffle assembly)|go:"GO:1900245"(positive regulation of MDA-5 signaling pathway)|go:"GO:1900246"(positive regulation of RIG-I signaling pathway)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|reactome:R-HSA-5689880|reactome:R-HSA-9648002|go:"GO:0090315"(negative regulation of protein targeting to membrane)|refseq:NP_958804.2 ensembl:ENSG00000108468(gene)|ensembl:ENST00000225603(transcript)|ensembl:ENST00000393408(transcript)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0001939"(female pronucleus)|go:"GO:0001940"(male pronucleus)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0005819"(spindle)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010369"(chromocenter)|go:"GO:0019899"(enzyme binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0090734"(site of DNA damage)|go:"GO:1990226"(histone methyltransferase binding)|interpro:IPR000953(Chromo domain)|interpro:IPR008251(Chromo shadow)|interpro:IPR016197(Chromo domain-like)|interpro:IPR017984|interpro:IPR023779|interpro:IPR023780|mint:P83916|rcsb pdb:2FMM|rcsb pdb:3F2U|rcsb pdb:3Q6S|rcsb pdb:5T1G|rcsb pdb:6D07|rcsb pdb:6D08|reactome:R-HSA-9609690|refseq:NP_001120700.1|refseq:NP_006798.1|dip:DIP-28135N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:ECUDXiuY+fF/Se+hz7Y9ZVX0y/A9606 rogid:W2npW/vFRcuTkStKpknsAP69q6I9606 intact-crc:9C8A803C99D7E48A|rigid:nJBInnq8cLkZ1kVDAdmtNJXlLVs false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q01804 uniprotkb:P04181 intact:EBI-1054396|uniprotkb:Q147U2|uniprotkb:Q1ZYK1|uniprotkb:Q6PG39|uniprotkb:Q96MQ5|uniprotkb:Q9NT94|uniprotkb:Q9UPV6|uniprotkb:B4DYS4|ensembl:ENSP00000395487 intact:EBI-721662|uniprotkb:Q68CS0|uniprotkb:Q16068|uniprotkb:Q16069|uniprotkb:Q9UD03|intact:EBI-1237002|uniprotkb:Q6IAV9|uniprotkb:D3DRF0|ensembl:ENSP00000357838 psi-mi:otud4_human(display_long)|uniprotkb:HIN-1(gene name synonym)|uniprotkb:HIV-1-induced protein HIN-1(gene name synonym)|uniprotkb:OTUD4(gene name)|psi-mi:OTUD4(display_short)|uniprotkb:KIAA1046(gene name synonym) psi-mi:oat_human(display_long)|uniprotkb:Ornithine--oxo-acid aminotransferase(gene name synonym)|uniprotkb:OAT(gene name)|psi-mi:OAT(display_short)|uniprotkb:Ornithine delta-aminotransferase(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513303|imex:IM-12079-30 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_005263136.1|refseq:NP_001096123.1|refseq:NP_059963.1|ensembl:ENSG00000164164(gene)|ensembl:ENST00000447906(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0045087"(innate immune response)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061578"(Lys63-specific deubiquitinase activity)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:1901537"(positive regulation of DNA demethylation)|go:"GO:1903093"(regulation of protein K48-linked deubiquitination)|go:"GO:2000660"(negative regulation of interleukin-1-mediated signaling pathway)|interpro:IPR003323(Ovarian tumour, otubain)|interpro:IPR038765 refseq:NP_000265.1|refseq:NP_001165285.1|refseq:NP_001309894.1|refseq:NP_001309895.1|refseq:NP_001309896.1|refseq:NP_001309897.1|refseq:NP_001309898.1|refseq:NP_001309899.1|refseq:NP_001309900.1|rcsb pdb:6OIA|rcsb pdb:6V8C|rcsb pdb:6V8D|rcsb pdb:7JX9|reactome:R-HSA-8964539|ensembl:ENSG00000065154(gene)|ensembl:ENST00000368845(transcript)|go:"GO:0004587"(ornithine-oxo-acid transaminase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0007601"(visual perception)|go:"GO:0010121"(arginine catabolic process to proline via ornithine)|go:"GO:0019544"(arginine catabolic process to glutamate)|go:"GO:0030170"(pyridoxal phosphate binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0050155"("ornithine(lysine) transaminase activity")|go:"GO:0055129"(L-proline biosynthetic process)|interpro:IPR005814(Aminotransferase class-III)|interpro:IPR010164(Ornithine aminotransferase)|interpro:IPR015421(Pyridoxal phosphate-dependent transferase, major region, subdomain 1)|interpro:IPR015422(Pyridoxal phosphate-dependent transferase, major region, subdomain 2)|interpro:IPR015424(Pyridoxal phosphate-dependent transferase, major region)|rcsb pdb:1GBN|rcsb pdb:1OAT|rcsb pdb:2BYJ|rcsb pdb:2BYL|rcsb pdb:2CAN|rcsb pdb:2OAT|rcsb pdb:5VWO|rcsb pdb:6HX7 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:humMGfho0HKWE4zhO7+G00gIJfc9606 rogid:j+e5fOgz5Yv7lLp2NV8Uq+eR6909606 intact-crc:97A74C935150795D|rigid:xEcQF51lQcmQmYEi9F+l0NfjNqY false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q01804 uniprotkb:O76013 intact:EBI-1054396|uniprotkb:Q147U2|uniprotkb:Q1ZYK1|uniprotkb:Q6PG39|uniprotkb:Q96MQ5|uniprotkb:Q9NT94|uniprotkb:Q9UPV6|uniprotkb:B4DYS4|ensembl:ENSP00000395487 intact:EBI-1054946|uniprotkb:Q86XG4|ensembl:ENSP00000329165 psi-mi:otud4_human(display_long)|uniprotkb:HIN-1(gene name synonym)|uniprotkb:HIV-1-induced protein HIN-1(gene name synonym)|uniprotkb:OTUD4(gene name)|psi-mi:OTUD4(display_short)|uniprotkb:KIAA1046(gene name synonym) psi-mi:krt36_human(display_long)|uniprotkb:KRTHA6(gene name synonym)|uniprotkb:Hair keratin, type I Ha6(gene name synonym)|uniprotkb:Keratin-36(gene name synonym)|uniprotkb:KRT36(gene name)|psi-mi:KRT36(display_short)|uniprotkb:HHA6(gene name synonym)|uniprotkb:HKA6(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513303|imex:IM-12079-30 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_005263136.1|refseq:NP_001096123.1|refseq:NP_059963.1|ensembl:ENSG00000164164(gene)|ensembl:ENST00000447906(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0045087"(innate immune response)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061578"(Lys63-specific deubiquitinase activity)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:1901537"(positive regulation of DNA demethylation)|go:"GO:1903093"(regulation of protein K48-linked deubiquitination)|go:"GO:2000660"(negative regulation of interleukin-1-mediated signaling pathway)|interpro:IPR003323(Ovarian tumour, otubain)|interpro:IPR038765 refseq:NP_003762.1|ensembl:ENSG00000126337(gene)|ensembl:ENST00000328119(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005882"(intermediate filament)|go:"GO:0030280"(structural constituent of skin epidermis)|go:"GO:0045616"(regulation of keratinocyte differentiation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002957(Keratin, type I)|interpro:IPR018039|interpro:IPR039008|reactome:R-HSA-6805567|reactome:R-HSA-6809371 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:humMGfho0HKWE4zhO7+G00gIJfc9606 rogid:T3L08n7jEhsouGDkQuK0jBLanBQ9606 intact-crc:97A74C935150795D|rigid:xEcQF51lQcmQmYEi9F+l0NfjNqY false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q01804 uniprotkb:Q16653 intact:EBI-1054396|uniprotkb:Q147U2|uniprotkb:Q1ZYK1|uniprotkb:Q6PG39|uniprotkb:Q96MQ5|uniprotkb:Q9NT94|uniprotkb:Q9UPV6|uniprotkb:B4DYS4|ensembl:ENSP00000395487 intact:EBI-2513281|uniprotkb:Q5STM2|uniprotkb:O00713|uniprotkb:Q93053|uniprotkb:Q14855|uniprotkb:Q92895|uniprotkb:Q92893|uniprotkb:Q92892|uniprotkb:O00714|uniprotkb:Q96KU9|uniprotkb:Q5SUK8|uniprotkb:Q13055|uniprotkb:Q99605|uniprotkb:Q96KV1|uniprotkb:O00715|uniprotkb:Q13054|uniprotkb:B0UZR9|uniprotkb:Q92894|uniprotkb:Q92891|uniprotkb:Q96KV0|uniprotkb:A6NDR4|uniprotkb:Q5JNY4|uniprotkb:Q5SSB5|uniprotkb:Q5STM0|uniprotkb:Q5JNY1|uniprotkb:Q5SSB6|uniprotkb:Q5STM5|uniprotkb:A8MY31|uniprotkb:Q5SUK7|uniprotkb:Q5SUK9|uniprotkb:Q5SUL0|uniprotkb:Q5SUL1|ensembl:ENSP00000259891|ensembl:ENSP00000352534|ensembl:ENSP00000366115|ensembl:ENSP00000373013|ensembl:ENSP00000373017|ensembl:ENSP00000373126|ensembl:ENSP00000373127|ensembl:ENSP00000383510|ensembl:ENSP00000383526|ensembl:ENSP00000383528|ensembl:ENSP00000389022|ensembl:ENSP00000389221|ensembl:ENSP00000390469|ensembl:ENSP00000390632|ensembl:ENSP00000390682|ensembl:ENSP00000391516|ensembl:ENSP00000391898|ensembl:ENSP00000394873|ensembl:ENSP00000395005|ensembl:ENSP00000397101|ensembl:ENSP00000397723|ensembl:ENSP00000397837|ensembl:ENSP00000398197|ensembl:ENSP00000398394|ensembl:ENSP00000399240|ensembl:ENSP00000401609|ensembl:ENSP00000402139|ensembl:ENSP00000403058|ensembl:ENSP00000403380|ensembl:ENSP00000404149|ensembl:ENSP00000404245|ensembl:ENSP00000404537|ensembl:ENSP00000404957|ensembl:ENSP00000409534|ensembl:ENSP00000410268|ensembl:ENSP00000410699|ensembl:ENSP00000411489|ensembl:ENSP00000413364|ensembl:ENSP00000413370|ensembl:ENSP00000414146|ensembl:ENSP00000414489|ensembl:ENSP00000383512|ensembl:ENSP00000414862|ensembl:ENSP00000415883|ensembl:ENSP00000446871|ensembl:ENSP00000447099|ensembl:ENSP00000448732|ensembl:ENSP00000448879|ensembl:ENSP00000449213|ensembl:ENSP00000449683|uniprotkb:E9PGF0|uniprotkb:F8W9D5|uniprotkb:Q29ZN8|uniprotkb:Q56UY0|uniprotkb:Q5JNX7|uniprotkb:Q5STL9|uniprotkb:A6NNJ9|uniprotkb:Q5JNY2|uniprotkb:Q5STM1|uniprotkb:Q5SUK5|uniprotkb:Q8IYG5 psi-mi:otud4_human(display_long)|uniprotkb:HIN-1(gene name synonym)|uniprotkb:HIV-1-induced protein HIN-1(gene name synonym)|uniprotkb:OTUD4(gene name)|psi-mi:OTUD4(display_short)|uniprotkb:KIAA1046(gene name synonym) psi-mi:mog_human(display_long)|uniprotkb:MOG(gene name)|psi-mi:MOG(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513303|imex:IM-12079-30 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_005263136.1|refseq:NP_001096123.1|refseq:NP_059963.1|ensembl:ENSG00000164164(gene)|ensembl:ENST00000447906(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0045087"(innate immune response)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061578"(Lys63-specific deubiquitinase activity)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:1901537"(positive regulation of DNA demethylation)|go:"GO:1903093"(regulation of protein K48-linked deubiquitination)|go:"GO:2000660"(negative regulation of interleukin-1-mediated signaling pathway)|interpro:IPR003323(Ovarian tumour, otubain)|interpro:IPR038765 refseq:XP_005249188.1|refseq:NP_001008229.1|refseq:NP_001008230.1|refseq:NP_001163889.1|refseq:NP_002424.3|refseq:NP_996532.2|refseq:NP_996533.2|refseq:NP_996534.2|refseq:NP_996535.2|refseq:NP_996537.3|ensembl:ENSG00000137345(gene)|ensembl:ENSG00000204655(gene)|ensembl:ENSG00000230885(gene)|ensembl:ENSG00000232641(gene)|ensembl:ENSG00000234096(gene)|ensembl:ENSG00000234623(gene)|ensembl:ENSG00000236561(gene)|ensembl:ENSG00000237834(gene)|ensembl:ENST00000259891(transcript)|ensembl:ENST00000359539(transcript)|ensembl:ENST00000376917(transcript)|ensembl:ENST00000383521(transcript)|ensembl:ENST00000383525(transcript)|ensembl:ENST00000383630(transcript)|ensembl:ENST00000383631(transcript)|ensembl:ENST00000400669(transcript)|ensembl:ENST00000400671(transcript)|ensembl:ENST00000400688(transcript)|ensembl:ENST00000400691(transcript)|ensembl:ENST00000412760(transcript)|ensembl:ENST00000414889(transcript)|ensembl:ENST00000550849(transcript)|ensembl:ENST00000551175(transcript)|ensembl:ENST00000551993(transcript)|ensembl:ENST00000553111(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007417"(central nervous system development)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016663(Myelin-oligodendrocyte glycoprotein)|interpro:IPR036179|mint:Q16653|rcsb pdb:1Q70|ensembl:ENST00000415546(transcript)|ensembl:ENST00000417019(transcript)|ensembl:ENST00000419274(transcript)|ensembl:ENST00000419309(transcript)|ensembl:ENST00000420045(transcript)|ensembl:ENST00000423895(transcript)|ensembl:ENST00000425145(transcript)|ensembl:ENST00000426782(transcript)|ensembl:ENST00000427289(transcript)|ensembl:ENST00000428719(transcript)|ensembl:ENST00000430264(transcript)|ensembl:ENST00000430351(transcript)|ensembl:ENST00000432271(transcript)|ensembl:ENST00000433500(transcript)|ensembl:ENST00000434177(transcript)|ensembl:ENST00000438803(transcript)|ensembl:ENST00000439634(transcript)|ensembl:ENST00000439884(transcript)|ensembl:ENST00000440561(transcript)|ensembl:ENST00000442244(transcript)|ensembl:ENST00000442444(transcript)|ensembl:ENST00000442629(transcript)|ensembl:ENST00000444674(transcript)|ensembl:ENST00000447285(transcript)|ensembl:ENST00000448816(transcript)|ensembl:ENST00000449096(transcript)|ensembl:ENST00000452233(transcript)|ensembl:ENST00000452744(transcript)|ensembl:ENST00000457090(transcript)|ensembl:ENST00000457626(transcript)|ensembl:ENST00000458179(transcript)|ensembl:ENST00000547083(transcript)|ensembl:ENST00000548017(transcript) psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:humMGfho0HKWE4zhO7+G00gIJfc9606 rogid:YVsyXFTiryBw45HJ517wN+n37/A9606 intact-crc:97A74C935150795D|rigid:xEcQF51lQcmQmYEi9F+l0NfjNqY false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q01804 uniprotkb:Q96D46 intact:EBI-1054396|uniprotkb:Q147U2|uniprotkb:Q1ZYK1|uniprotkb:Q6PG39|uniprotkb:Q96MQ5|uniprotkb:Q9NT94|uniprotkb:Q9UPV6|uniprotkb:B4DYS4|ensembl:ENSP00000395487 intact:EBI-2371176|uniprotkb:Q9Y2Z6|uniprotkb:D3DNM7|ensembl:ENSP00000307525|ensembl:ENSP00000419004 psi-mi:otud4_human(display_long)|uniprotkb:HIN-1(gene name synonym)|uniprotkb:HIV-1-induced protein HIN-1(gene name synonym)|uniprotkb:OTUD4(gene name)|psi-mi:OTUD4(display_short)|uniprotkb:KIAA1046(gene name synonym) psi-mi:nmd3_human(display_long)|uniprotkb:NMD3(gene name)|psi-mi:NMD3(display_short)|uniprotkb:CGI-07(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513303|imex:IM-12079-30 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_005263136.1|refseq:NP_001096123.1|refseq:NP_059963.1|ensembl:ENSG00000164164(gene)|ensembl:ENST00000447906(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0045087"(innate immune response)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061578"(Lys63-specific deubiquitinase activity)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:1901537"(positive regulation of DNA demethylation)|go:"GO:1903093"(regulation of protein K48-linked deubiquitination)|go:"GO:2000660"(negative regulation of interleukin-1-mediated signaling pathway)|interpro:IPR003323(Ovarian tumour, otubain)|interpro:IPR038765 refseq:NP_057022.2|refseq:XP_005247568.1|refseq:XP_005247569.1|dip:DIP-53427N|ensembl:ENSG00000169251(gene)|ensembl:ENST00000351193(transcript)|ensembl:ENST00000460469(transcript)|go:"GO:0000055"(ribosomal large subunit export from nucleus)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0043023"(ribosomal large subunit binding)|go:"GO:1902680"(positive regulation of RNA biosynthetic process)|go:"GO:1904751"(positive regulation of protein localization to nucleolus)|interpro:IPR007064(NMD3)|interpro:IPR039768|mint:Q96D46|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LU8 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:humMGfho0HKWE4zhO7+G00gIJfc9606 rogid:ufeZYizNnQTOnJjgF+zmyLQphJE9606 intact-crc:97A74C935150795D|rigid:xEcQF51lQcmQmYEi9F+l0NfjNqY false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q01804 uniprotkb:Q14525 intact:EBI-1054396|uniprotkb:Q147U2|uniprotkb:Q1ZYK1|uniprotkb:Q6PG39|uniprotkb:Q96MQ5|uniprotkb:Q9NT94|uniprotkb:Q9UPV6|uniprotkb:B4DYS4|ensembl:ENSP00000395487 intact:EBI-1049638|uniprotkb:O76010|ensembl:ENSP00000251646|ensembl:ENSP00000459509 psi-mi:otud4_human(display_long)|uniprotkb:HIN-1(gene name synonym)|uniprotkb:HIV-1-induced protein HIN-1(gene name synonym)|uniprotkb:OTUD4(gene name)|psi-mi:OTUD4(display_short)|uniprotkb:KIAA1046(gene name synonym) psi-mi:kt33b_human(display_long)|uniprotkb:KRTHA3B(gene name synonym)|uniprotkb:Hair keratin, type I Ha3-II(gene name synonym)|uniprotkb:Keratin-33B(gene name synonym)|uniprotkb:KRT33B(gene name)|psi-mi:KRT33B(display_short)|uniprotkb:HHA3-II(gene name synonym)|uniprotkb:HKA3B(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513303|imex:IM-12079-30 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_005263136.1|refseq:NP_001096123.1|refseq:NP_059963.1|ensembl:ENSG00000164164(gene)|ensembl:ENST00000447906(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0045087"(innate immune response)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061578"(Lys63-specific deubiquitinase activity)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:1901537"(positive regulation of DNA demethylation)|go:"GO:1903093"(regulation of protein K48-linked deubiquitination)|go:"GO:2000660"(negative regulation of interleukin-1-mediated signaling pathway)|interpro:IPR003323(Ovarian tumour, otubain)|interpro:IPR038765 refseq:NP_002270.1|ensembl:ENSG00000131738(gene)|ensembl:ENSG00000263012(gene)|ensembl:ENST00000251646(transcript)|ensembl:ENST00000570596(transcript)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005829"(cytosol)|go:"GO:0005882"(intermediate filament)|go:"GO:0007568"(aging)|go:"GO:0042633"(hair cycle)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002957(Keratin, type I)|interpro:IPR018039|interpro:IPR039008|mint:Q14525|reactome:R-HSA-6805567|reactome:R-HSA-6809371 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:humMGfho0HKWE4zhO7+G00gIJfc9606 rogid:TDqltAJBdpwMGaQsl0Lznc8Y7Ns9606 intact-crc:97A74C935150795D|rigid:xEcQF51lQcmQmYEi9F+l0NfjNqY false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q01804 uniprotkb:Q15323 intact:EBI-1054396|uniprotkb:Q147U2|uniprotkb:Q1ZYK1|uniprotkb:Q6PG39|uniprotkb:Q96MQ5|uniprotkb:Q9NT94|uniprotkb:Q9UPV6|uniprotkb:B4DYS4|ensembl:ENSP00000395487 intact:EBI-948001|uniprotkb:Q9UE12|ensembl:ENSP00000251645|ensembl:ENSP00000460739 psi-mi:otud4_human(display_long)|uniprotkb:HIN-1(gene name synonym)|uniprotkb:HIV-1-induced protein HIN-1(gene name synonym)|uniprotkb:OTUD4(gene name)|psi-mi:OTUD4(display_short)|uniprotkb:KIAA1046(gene name synonym) psi-mi:k1h1_human(display_long)|uniprotkb:Hair keratin, type I Ha1(gene name synonym)|uniprotkb:Keratin-31(gene name synonym)|uniprotkb:KRT31(gene name)|psi-mi:KRT31(display_short)|uniprotkb:HHA1(gene name synonym)|uniprotkb:HKA1(gene name synonym)|uniprotkb:KRTHA1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513303|imex:IM-12079-30 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_005263136.1|refseq:NP_001096123.1|refseq:NP_059963.1|ensembl:ENSG00000164164(gene)|ensembl:ENST00000447906(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0045087"(innate immune response)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061578"(Lys63-specific deubiquitinase activity)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:1901537"(positive regulation of DNA demethylation)|go:"GO:1903093"(regulation of protein K48-linked deubiquitination)|go:"GO:2000660"(negative regulation of interleukin-1-mediated signaling pathway)|interpro:IPR003323(Ovarian tumour, otubain)|interpro:IPR038765 refseq:NP_002268.2|ensembl:ENSG00000094796(gene)|ensembl:ENSG00000262993(gene)|ensembl:ENST00000251645(transcript)|ensembl:ENST00000573281(transcript)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005615"(extracellular space)|go:"GO:0005829"(cytosol)|go:"GO:0005882"(intermediate filament)|go:"GO:0008544"(epidermis development)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002957(Keratin, type I)|interpro:IPR018039|interpro:IPR039008|reactome:R-HSA-6805567|reactome:R-HSA-6809371 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:humMGfho0HKWE4zhO7+G00gIJfc9606 rogid:ur97LEvtqaqu3wh7iaX4HhN163k9606 intact-crc:97A74C935150795D|rigid:xEcQF51lQcmQmYEi9F+l0NfjNqY false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q01804 uniprotkb:Q86YZ3 intact:EBI-1054396|uniprotkb:Q147U2|uniprotkb:Q1ZYK1|uniprotkb:Q6PG39|uniprotkb:Q96MQ5|uniprotkb:Q9NT94|uniprotkb:Q9UPV6|uniprotkb:B4DYS4|ensembl:ENSP00000395487 intact:EBI-1047017|uniprotkb:Q5U1F4|ensembl:ENSP00000357791|uniprotkb:Q5DT20 psi-mi:otud4_human(display_long)|uniprotkb:HIN-1(gene name synonym)|uniprotkb:HIV-1-induced protein HIN-1(gene name synonym)|uniprotkb:OTUD4(gene name)|psi-mi:OTUD4(display_short)|uniprotkb:KIAA1046(gene name synonym) psi-mi:horn_human(display_long)|uniprotkb:HRNR(gene name)|psi-mi:HRNR(display_short)|uniprotkb:S100A18(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513303|imex:IM-12079-30 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_005263136.1|refseq:NP_001096123.1|refseq:NP_059963.1|ensembl:ENSG00000164164(gene)|ensembl:ENST00000447906(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0045087"(innate immune response)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061578"(Lys63-specific deubiquitinase activity)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:1901537"(positive regulation of DNA demethylation)|go:"GO:1903093"(regulation of protein K48-linked deubiquitination)|go:"GO:2000660"(negative regulation of interleukin-1-mediated signaling pathway)|interpro:IPR003323(Ovarian tumour, otubain)|interpro:IPR038765 refseq:NP_001009931.1|ensembl:ENSG00000197915(gene)|ensembl:ENST00000368801(transcript)|go:"GO:0001533"(cornified envelope)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0031424"(keratinization)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0036457"(keratohyalin granule)|go:"GO:0043163"(cell envelope organization)|go:"GO:0046914"(transition metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0061436"(establishment of skin barrier)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001751(S100/CaBP-9k-type, calcium binding)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR013787(S100/CaBP-9k-type, calcium binding, subdomain)|interpro:IPR018247|interpro:IPR033201|interpro:IPR034325|mint:Q86YZ3|reactome:R-HSA-6798695|ensembl:ENSP00000357791 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:humMGfho0HKWE4zhO7+G00gIJfc9606 rogid:j5ATFM7OQGbf5j+CZpJ3bJoadnc9606 intact-crc:97A74C935150795D|rigid:xEcQF51lQcmQmYEi9F+l0NfjNqY false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q01804 uniprotkb:Q71U36 intact:EBI-1054396|uniprotkb:Q147U2|uniprotkb:Q1ZYK1|uniprotkb:Q6PG39|uniprotkb:Q96MQ5|uniprotkb:Q9NT94|uniprotkb:Q9UPV6|uniprotkb:B4DYS4|ensembl:ENSP00000395487 intact:EBI-302552|uniprotkb:P04687|uniprotkb:P05209|uniprotkb:A8K0B8|uniprotkb:G3V1U9|intact:EBI-10989786|ensembl:ENSP00000301071|ensembl:ENSP00000439020 psi-mi:otud4_human(display_long)|uniprotkb:HIN-1(gene name synonym)|uniprotkb:HIV-1-induced protein HIN-1(gene name synonym)|uniprotkb:OTUD4(gene name)|psi-mi:OTUD4(display_short)|uniprotkb:KIAA1046(gene name synonym) psi-mi:tba1a_human(display_long)|uniprotkb:TUBA1A(gene name)|psi-mi:TUBA1A(display_short)|uniprotkb:Tubulin B-alpha-1(gene name synonym)|uniprotkb:Tubulin alpha-3 chain(gene name synonym)|uniprotkb:Alpha-tubulin 3(gene name synonym)|uniprotkb:TUBA3(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513303|imex:IM-12079-30 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_005263136.1|refseq:NP_001096123.1|refseq:NP_059963.1|ensembl:ENSG00000164164(gene)|ensembl:ENST00000447906(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0045087"(innate immune response)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061578"(Lys63-specific deubiquitinase activity)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:1901537"(positive regulation of DNA demethylation)|go:"GO:1903093"(regulation of protein K48-linked deubiquitination)|go:"GO:2000660"(negative regulation of interleukin-1-mediated signaling pathway)|interpro:IPR003323(Ovarian tumour, otubain)|interpro:IPR038765 refseq:NP_006000.2|refseq:NP_001257328.1|refseq:NP_001257329.1|dip:DIP-32773N|ensembl:ENSG00000167552(gene)|ensembl:ENST00000295766(transcript)|ensembl:ENST00000301071(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0007017"(microtubule-based process)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030705"(cytoskeleton-dependent intracellular transport)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0043209"(myelin sheath)|go:"GO:0045121"(membrane raft)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0051301"(cell division)|go:"GO:0055037"(recycling endosome)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000217(Tubulin)|interpro:IPR002452(Alpha tubulin)|interpro:IPR003008(Tubulin/FtsZ, GTPase)|interpro:IPR008280(Tubulin/FtsZ, C-terminal)|interpro:IPR017975|interpro:IPR018316|interpro:IPR023123|interpro:IPR036525|interpro:IPR037103|mint:Q71U36|rcsb pdb:5JCO|rcsb pdb:6J8F|rcsb pdb:6WSL|rcsb pdb:7C1M|reactome:R-HSA-1445148|reactome:R-HSA-9646399|reactome:R-HSA-9648025|reactome:R-HSA-9668328|reactome:R-HSA-983189|reactome:R-HSA-190840|reactome:R-HSA-190861|reactome:R-HSA-2132295|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-2565942|reactome:R-HSA-3371497|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-389977|reactome:R-HSA-437239|reactome:R-HSA-5610787|reactome:R-HSA-5617833|reactome:R-HSA-5620912|reactome:R-HSA-5620924|reactome:R-HSA-5626467|reactome:R-HSA-5663220|reactome:R-HSA-6807878|reactome:R-HSA-6811434|reactome:R-HSA-6811436|reactome:R-HSA-68877|reactome:R-HSA-8852276|reactome:R-HSA-8854518|reactome:R-HSA-8955332|reactome:R-HSA-9609690|reactome:R-HSA-9609736|reactome:R-HSA-9619483 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:humMGfho0HKWE4zhO7+G00gIJfc9606 rogid:1CzEzrf5y8hrQRPKgWQS1Wm1aCY9606 intact-crc:97A74C935150795D|rigid:xEcQF51lQcmQmYEi9F+l0NfjNqY false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q01804 uniprotkb:Q9NQX3 intact:EBI-1054396|uniprotkb:Q147U2|uniprotkb:Q1ZYK1|uniprotkb:Q6PG39|uniprotkb:Q96MQ5|uniprotkb:Q9NT94|uniprotkb:Q9UPV6|uniprotkb:B4DYS4|ensembl:ENSP00000395487 intact:EBI-2371891|uniprotkb:Q9H4E9|uniprotkb:Q9P2G2|uniprotkb:Q96KU4|ensembl:ENSP00000312771 psi-mi:otud4_human(display_long)|uniprotkb:HIN-1(gene name synonym)|uniprotkb:HIV-1-induced protein HIN-1(gene name synonym)|uniprotkb:OTUD4(gene name)|psi-mi:OTUD4(display_short)|uniprotkb:KIAA1046(gene name synonym) psi-mi:geph_human(display_long)|uniprotkb:GPHN(gene name)|psi-mi:GPHN(display_short)|uniprotkb:GPH(gene name synonym)|uniprotkb:KIAA1385(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513303|imex:IM-12079-30 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_005263136.1|refseq:NP_001096123.1|refseq:NP_059963.1|ensembl:ENSG00000164164(gene)|ensembl:ENST00000447906(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0045087"(innate immune response)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061578"(Lys63-specific deubiquitinase activity)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:1901537"(positive regulation of DNA demethylation)|go:"GO:1903093"(regulation of protein K48-linked deubiquitination)|go:"GO:2000660"(negative regulation of interleukin-1-mediated signaling pathway)|interpro:IPR003323(Ovarian tumour, otubain)|interpro:IPR038765 refseq:NP_001019389.1|refseq:NP_065857.1|dip:DIP-41076N|rcsb pdb:1JLJ|reactome:R-HSA-947581|interpro:IPR038987|ensembl:ENSG00000171723(gene)|ensembl:ENST00000315266(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006777"(Mo-molybdopterin cofactor biosynthetic process)|go:"GO:0007529"(establishment of synaptic specificity at neuromuscular junction)|go:"GO:0008940"(nitrate reductase activity)|go:"GO:0010038"(response to metal ion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0018315"(molybdenum incorporation into molybdenum-molybdopterin complex)|go:"GO:0030425"(dendrite)|go:"GO:0032324"(molybdopterin cofactor biosynthetic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043546"(molybdopterin cofactor binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0061598"(molybdopterin adenylyltransferase activity)|go:"GO:0061599"(molybdopterin molybdotransferase activity)|go:"GO:0072579"(glycine receptor clustering)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097112"(gamma-aminobutyric acid receptor clustering)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0099144"(anchored component of synaptic membrane)|go:"GO:0099572"(postsynaptic specialization)|go:"GO:0099634"(postsynaptic specialization membrane)|interpro:IPR001453(Molybdopterin binding)|interpro:IPR005110(MoeA, N-terminal, domain I and II)|interpro:IPR005111(MoeA, C-terminal, domain IV)|interpro:IPR008284(Molybdenum cofactor biosynthesis, conserved site)|interpro:IPR036135|interpro:IPR036425|interpro:IPR036688 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:humMGfho0HKWE4zhO7+G00gIJfc9606 rogid:iu4Nl7g9dOChbmYok/lo6kjW3pM9606 intact-crc:97A74C935150795D|rigid:xEcQF51lQcmQmYEi9F+l0NfjNqY false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q01804 uniprotkb:Q14315 intact:EBI-1054396|uniprotkb:Q147U2|uniprotkb:Q1ZYK1|uniprotkb:Q6PG39|uniprotkb:Q96MQ5|uniprotkb:Q9NT94|uniprotkb:Q9UPV6|uniprotkb:B4DYS4|ensembl:ENSP00000395487 intact:EBI-489954|uniprotkb:O95303|uniprotkb:Q07985|uniprotkb:Q9NS12|uniprotkb:Q9NYE5|uniprotkb:Q9UMR8|uniprotkb:Q9Y503|uniprotkb:B2ZZ88|ensembl:ENSP00000327145 psi-mi:otud4_human(display_long)|uniprotkb:HIN-1(gene name synonym)|uniprotkb:HIV-1-induced protein HIN-1(gene name synonym)|uniprotkb:OTUD4(gene name)|psi-mi:OTUD4(display_short)|uniprotkb:KIAA1046(gene name synonym) psi-mi:flnc_human(display_long)|uniprotkb:Filamin-2(gene name synonym)|uniprotkb:Actin-binding-like protein(gene name synonym)|uniprotkb:ABP-L(gene name synonym)|uniprotkb:ABP-280-like protein(gene name synonym)|uniprotkb:Gamma-filamin(gene name synonym)|uniprotkb:FLNC(gene name)|psi-mi:FLNC(display_short)|uniprotkb:ABPL(gene name synonym)|uniprotkb:FLN2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513303|imex:IM-12079-30 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_005263136.1|refseq:NP_001096123.1|refseq:NP_059963.1|ensembl:ENSG00000164164(gene)|ensembl:ENST00000447906(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0045087"(innate immune response)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061578"(Lys63-specific deubiquitinase activity)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:1901537"(positive regulation of DNA demethylation)|go:"GO:1903093"(regulation of protein K48-linked deubiquitination)|go:"GO:2000660"(negative regulation of interleukin-1-mediated signaling pathway)|interpro:IPR003323(Ovarian tumour, otubain)|interpro:IPR038765 refseq:NP_001120959.1|refseq:NP_001449.3|ensembl:ENSG00000128591(gene)|ensembl:ENST00000325888(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0016528"(sarcoplasm)|go:"GO:0030018"(Z disc)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030506"(ankyrin binding)|go:"GO:0042383"(sarcolemma)|go:"GO:0042802"(identical protein binding)|go:"GO:0043034"(costamere)|go:"GO:0051015"(actin filament binding)|go:"GO:0055001"(muscle cell development)|interpro:IPR001298(Filamin/ABP280 repeat)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017868|interpro:IPR036872|interpro:IPR044801|mint:Q14315|rcsb pdb:1V05|rcsb pdb:2D7M|rcsb pdb:2D7N|rcsb pdb:2D7O|rcsb pdb:2D7P|rcsb pdb:2D7Q|rcsb pdb:2K9U|rcsb pdb:2NQC|rcsb pdb:3V8O|rcsb pdb:4MGX|reactome:R-HSA-446353|dip:DIP-33398N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:humMGfho0HKWE4zhO7+G00gIJfc9606 rogid:sBGhjObBECicoAu/8T5lDIt1ToY9606 intact-crc:97A74C935150795D|rigid:xEcQF51lQcmQmYEi9F+l0NfjNqY false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q01804 uniprotkb:P78386 intact:EBI-1054396|uniprotkb:Q147U2|uniprotkb:Q1ZYK1|uniprotkb:Q6PG39|uniprotkb:Q96MQ5|uniprotkb:Q9NT94|uniprotkb:Q9UPV6|uniprotkb:B4DYS4|ensembl:ENSP00000395487 intact:EBI-1049371|uniprotkb:Q9NSB1|ensembl:ENSP00000257901 psi-mi:otud4_human(display_long)|uniprotkb:HIN-1(gene name synonym)|uniprotkb:HIV-1-induced protein HIN-1(gene name synonym)|uniprotkb:OTUD4(gene name)|psi-mi:OTUD4(display_short)|uniprotkb:KIAA1046(gene name synonym) psi-mi:krt85_human(display_long)|uniprotkb:Type II hair keratin Hb5(gene name synonym)|uniprotkb:Keratin-85(gene name synonym)|uniprotkb:Hair keratin K2.12(gene name synonym)|uniprotkb:KRT85(gene name)|psi-mi:KRT85(display_short)|uniprotkb:KRTHB5(gene name synonym)|uniprotkb:Type-II keratin Kb25(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513303|imex:IM-12079-30 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_005263136.1|refseq:NP_001096123.1|refseq:NP_059963.1|ensembl:ENSG00000164164(gene)|ensembl:ENST00000447906(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0045087"(innate immune response)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061578"(Lys63-specific deubiquitinase activity)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:1901537"(positive regulation of DNA demethylation)|go:"GO:1903093"(regulation of protein K48-linked deubiquitination)|go:"GO:2000660"(negative regulation of interleukin-1-mediated signaling pathway)|interpro:IPR003323(Ovarian tumour, otubain)|interpro:IPR038765 refseq:NP_001287739.1|refseq:NP_002274.1|ensembl:ENSG00000135443(gene)|ensembl:ENST00000257901(transcript)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005829"(cytosol)|go:"GO:0008544"(epidermis development)|go:"GO:0045095"(keratin filament)|interpro:IPR003054(Type II keratin)|interpro:IPR018039|interpro:IPR032444|interpro:IPR039008|reactome:R-HSA-6805567|reactome:R-HSA-6809371 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:humMGfho0HKWE4zhO7+G00gIJfc9606 rogid:O+5NoIWK84IGOos3h32HHMjZE889606 intact-crc:97A74C935150795D|rigid:xEcQF51lQcmQmYEi9F+l0NfjNqY false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q01804 uniprotkb:P06280 intact:EBI-1054396|uniprotkb:Q147U2|uniprotkb:Q1ZYK1|uniprotkb:Q6PG39|uniprotkb:Q96MQ5|uniprotkb:Q9NT94|uniprotkb:Q9UPV6|uniprotkb:B4DYS4|ensembl:ENSP00000395487 intact:EBI-2513305|ensembl:ENSP00000218516|uniprotkb:Q6LER7 psi-mi:otud4_human(display_long)|uniprotkb:HIN-1(gene name synonym)|uniprotkb:HIV-1-induced protein HIN-1(gene name synonym)|uniprotkb:OTUD4(gene name)|psi-mi:OTUD4(display_short)|uniprotkb:KIAA1046(gene name synonym) psi-mi:agal_human(display_long)|uniprotkb:GLA(gene name)|psi-mi:GLA(display_short)|uniprotkb:Alpha-D-galactoside galactohydrolase(gene name synonym)|uniprotkb:Alpha-D-galactosidase A(gene name synonym)|uniprotkb:Melibiase(gene name synonym)|uniprotkb:Galactosylgalactosylglucosylceramidase GLA(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513303|imex:IM-12079-30 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_005263136.1|refseq:NP_001096123.1|refseq:NP_059963.1|ensembl:ENSG00000164164(gene)|ensembl:ENST00000447906(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0045087"(innate immune response)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061578"(Lys63-specific deubiquitinase activity)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:1901537"(positive regulation of DNA demethylation)|go:"GO:1903093"(regulation of protein K48-linked deubiquitination)|go:"GO:2000660"(negative regulation of interleukin-1-mediated signaling pathway)|interpro:IPR003323(Ovarian tumour, otubain)|interpro:IPR038765 reactome:R-HSA-1660662|reactome:R-HSA-6798695|ensembl:ENSG00000102393(gene)|ensembl:ENST00000218516(transcript)|go:"GO:0003824"(catalytic activity)|go:"GO:0004557"(alpha-galactosidase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0009311"(oligosaccharide metabolic process)|go:"GO:0016139"(glycoside catabolic process)|go:"GO:0016787"(hydrolase activity)|go:"GO:0016936"(galactoside binding)|go:"GO:0017041"(galactosylgalactosylglucosylceramidase activity)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0045019"(negative regulation of nitric oxide biosynthetic process)|go:"GO:0046477"(glycosylceramide catabolic process)|go:"GO:0046479"(glycosphingolipid catabolic process)|go:"GO:0051001"(negative regulation of nitric-oxide synthase activity)|go:"GO:0052692"(raffinose alpha-galactosidase activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000111(Glycoside hydrolase, clan GH-D)|interpro:IPR002241(Glycoside hydrolase, family 27)|interpro:IPR013780(Glycosyl hydrolase, family 13, all-beta)|interpro:IPR013785(Aldolase-type TIM barrel)|interpro:IPR017853(Glycoside hydrolase, catalytic core)|interpro:IPR035373|rcsb pdb:1R46|rcsb pdb:1R47|rcsb pdb:3GXN|rcsb pdb:3GXP|rcsb pdb:3GXT|rcsb pdb:3HG2|rcsb pdb:3HG3|rcsb pdb:3HG4|rcsb pdb:3HG5|rcsb pdb:3LX9|rcsb pdb:3LXA|rcsb pdb:3LXB|rcsb pdb:3LXC|rcsb pdb:3S5Y|rcsb pdb:3S5Z|rcsb pdb:3TV8|rcsb pdb:4NXS|rcsb pdb:6IBK|rcsb pdb:6IBM|rcsb pdb:6IBR|rcsb pdb:6IBT|refseq:NP_000160.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:humMGfho0HKWE4zhO7+G00gIJfc9606 rogid:en4+xuRp2k6kcAkvM2Bla9N3+189606 intact-crc:97A74C935150795D|rigid:xEcQF51lQcmQmYEi9F+l0NfjNqY false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q01804 uniprotkb:Q99417 intact:EBI-1054396|uniprotkb:Q147U2|uniprotkb:Q1ZYK1|uniprotkb:Q6PG39|uniprotkb:Q96MQ5|uniprotkb:Q9NT94|uniprotkb:Q9UPV6|uniprotkb:B4DYS4|ensembl:ENSP00000395487 intact:EBI-716185|intact:EBI-2559925|uniprotkb:Q5TA64|uniprotkb:Q96HE2|uniprotkb:B2R4N0|ensembl:ENSP00000380702 psi-mi:otud4_human(display_long)|uniprotkb:HIN-1(gene name synonym)|uniprotkb:HIV-1-induced protein HIN-1(gene name synonym)|uniprotkb:OTUD4(gene name)|psi-mi:OTUD4(display_short)|uniprotkb:KIAA1046(gene name synonym) psi-mi:mycbp_human(display_long)|uniprotkb:Associate of Myc 1(gene name synonym)|uniprotkb:MYCBP(gene name)|psi-mi:MYCBP(display_short)|uniprotkb:AMY1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513303|imex:IM-12079-30 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_005263136.1|refseq:NP_001096123.1|refseq:NP_059963.1|ensembl:ENSG00000164164(gene)|ensembl:ENST00000447906(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0045087"(innate immune response)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061578"(Lys63-specific deubiquitinase activity)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:1901537"(positive regulation of DNA demethylation)|go:"GO:1903093"(regulation of protein K48-linked deubiquitination)|go:"GO:2000660"(negative regulation of interleukin-1-mediated signaling pathway)|interpro:IPR003323(Ovarian tumour, otubain)|interpro:IPR038765 refseq:NP_036465.2|ensembl:ENSG00000214114(gene)|ensembl:ENST00000397572(transcript)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007283"(spermatogenesis)|interpro:IPR026060|mint:Q99417|rcsb pdb:2YY0 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:humMGfho0HKWE4zhO7+G00gIJfc9606 rogid:jIStn1A10DDkgTuwVeKpDPJ6tIs9606 intact-crc:97A74C935150795D|rigid:xEcQF51lQcmQmYEi9F+l0NfjNqY false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q01804 uniprotkb:P51116 intact:EBI-1054396|uniprotkb:Q147U2|uniprotkb:Q1ZYK1|uniprotkb:Q6PG39|uniprotkb:Q96MQ5|uniprotkb:Q9NT94|uniprotkb:Q9UPV6|uniprotkb:B4DYS4|ensembl:ENSP00000395487 intact:EBI-740459|uniprotkb:Q8WUM2|uniprotkb:Q86V09|uniprotkb:B2R9M2|uniprotkb:D3DTQ1|ensembl:ENSP00000250113 psi-mi:otud4_human(display_long)|uniprotkb:HIN-1(gene name synonym)|uniprotkb:HIV-1-induced protein HIN-1(gene name synonym)|uniprotkb:OTUD4(gene name)|psi-mi:OTUD4(display_short)|uniprotkb:KIAA1046(gene name synonym) psi-mi:fxr2_human(display_long)|uniprotkb:FXR2(gene name)|psi-mi:FXR2(display_short)|uniprotkb:FMR1L2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513303|imex:IM-12079-30 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_005263136.1|refseq:NP_001096123.1|refseq:NP_059963.1|ensembl:ENSG00000164164(gene)|ensembl:ENST00000447906(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0045087"(innate immune response)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061578"(Lys63-specific deubiquitinase activity)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:1901537"(positive regulation of DNA demethylation)|go:"GO:1903093"(regulation of protein K48-linked deubiquitination)|go:"GO:2000660"(negative regulation of interleukin-1-mediated signaling pathway)|interpro:IPR003323(Ovarian tumour, otubain)|interpro:IPR038765 interpro:IPR004087(K Homology)|refseq:NP_004851.2|ensembl:ENSG00000129245(gene)|ensembl:ENST00000250113(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0098793"(presynapse)|go:"GO:1902737"(dendritic filopodium)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|interpro:IPR004088(K Homology, type 1)|interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR032172|interpro:IPR036612|interpro:IPR040148|interpro:IPR040472|interpro:IPR041560|mint:P51116|rcsb pdb:3H8Z psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:humMGfho0HKWE4zhO7+G00gIJfc9606 rogid:NnYgyzD2NRGIO1ZHukr5qy44qRE9606 intact-crc:97A74C935150795D|rigid:xEcQF51lQcmQmYEi9F+l0NfjNqY false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q01804 uniprotkb:P55786 intact:EBI-1054396|uniprotkb:Q147U2|uniprotkb:Q1ZYK1|uniprotkb:Q6PG39|uniprotkb:Q96MQ5|uniprotkb:Q9NT94|uniprotkb:Q9UPV6|uniprotkb:B4DYS4|ensembl:ENSP00000395487 intact:EBI-1046129|uniprotkb:Q6P145|uniprotkb:Q9NP16|uniprotkb:Q9UEM2|ensembl:ENSP00000320324|ensembl:ENSP00000503682|uniprotkb:B7Z463 psi-mi:otud4_human(display_long)|uniprotkb:HIN-1(gene name synonym)|uniprotkb:HIV-1-induced protein HIN-1(gene name synonym)|uniprotkb:OTUD4(gene name)|psi-mi:OTUD4(display_short)|uniprotkb:KIAA1046(gene name synonym) psi-mi:psa_human(display_long)|uniprotkb:NPEPPS(gene name)|psi-mi:NPEPPS(display_short)|uniprotkb:PSA(gene name synonym)|uniprotkb:Cytosol alanyl aminopeptidase(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513303|imex:IM-12079-30 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_005263136.1|refseq:NP_001096123.1|refseq:NP_059963.1|ensembl:ENSG00000164164(gene)|ensembl:ENST00000447906(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0045087"(innate immune response)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061578"(Lys63-specific deubiquitinase activity)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:1901537"(positive regulation of DNA demethylation)|go:"GO:1903093"(regulation of protein K48-linked deubiquitination)|go:"GO:2000660"(negative regulation of interleukin-1-mediated signaling pathway)|interpro:IPR003323(Ovarian tumour, otubain)|interpro:IPR038765 refseq:NP_006301.3|ensembl:ENSG00000141279(gene)|ensembl:ENST00000322157(transcript)|ensembl:ENST00000677120(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004177"(aminopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0042277"(peptide binding)|go:"GO:0043171"(peptide catabolic process)|go:"GO:0070006"(metalloaminopeptidase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|interpro:IPR001930(Peptidase M1, membrane alanine aminopeptidase)|interpro:IPR014782(Peptidase M1, membrane alanine aminopeptidase, N-terminal)|interpro:IPR024571|interpro:IPR027268|interpro:IPR034016|interpro:IPR042097|reactome:R-HSA-983168|refseq:NP_001317186.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:humMGfho0HKWE4zhO7+G00gIJfc9606 rogid:gDl9SPlJhCOhA8uF4OEw+lIPh2M9606 intact-crc:97A74C935150795D|rigid:xEcQF51lQcmQmYEi9F+l0NfjNqY false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q01804 uniprotkb:Q9UL15 intact:EBI-1054396|uniprotkb:Q147U2|uniprotkb:Q1ZYK1|uniprotkb:Q6PG39|uniprotkb:Q96MQ5|uniprotkb:Q9NT94|uniprotkb:Q9UPV6|uniprotkb:B4DYS4|ensembl:ENSP00000395487 intact:EBI-356517|uniprotkb:O94950|uniprotkb:Q86W59|ensembl:ENSP00000299204|ensembl:ENSP00000391713 psi-mi:otud4_human(display_long)|uniprotkb:HIN-1(gene name synonym)|uniprotkb:HIV-1-induced protein HIN-1(gene name synonym)|uniprotkb:OTUD4(gene name)|psi-mi:OTUD4(display_short)|uniprotkb:KIAA1046(gene name synonym) psi-mi:bag5_human(display_long)|uniprotkb:BAG5(gene name)|psi-mi:BAG5(display_short)|uniprotkb:KIAA0873(gene name synonym)|uniprotkb:Bcl-2-associated athanogene 5(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513303|imex:IM-12079-30 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_005263136.1|refseq:NP_001096123.1|refseq:NP_059963.1|ensembl:ENSG00000164164(gene)|ensembl:ENST00000447906(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0045087"(innate immune response)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061578"(Lys63-specific deubiquitinase activity)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:1901537"(positive regulation of DNA demethylation)|go:"GO:1903093"(regulation of protein K48-linked deubiquitination)|go:"GO:2000660"(negative regulation of interleukin-1-mediated signaling pathway)|interpro:IPR003323(Ovarian tumour, otubain)|interpro:IPR038765 refseq:NP_001015048.1|refseq:NP_001015049.1|refseq:NP_004864.1|go:"GO:0051444"(negative regulation of ubiquitin-protein transferase activity)|go:"GO:0061084"(negative regulation of protein refolding)|go:"GO:0070997"(neuron death)|go:"GO:0090083"(regulation of inclusion body assembly)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|interpro:IPR003103(Apoptosis regulator Bcl-2 protein, BAG)|interpro:IPR036533|interpro:IPR039773|mint:Q9UL15|rcsb pdb:2D9D|rcsb pdb:3A8Y|reactome:R-HSA-3371453|go:"GO:0051438"(regulation of ubiquitin-protein transferase activity)|ensembl:ENSG00000166170(gene)|ensembl:ENST00000299204(transcript)|ensembl:ENST00000445922(transcript)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0007030"(Golgi organization)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|dip:DIP-53428N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:humMGfho0HKWE4zhO7+G00gIJfc9606 rogid:I5E45kk4QcYF/BEa5qh7IBeBzF09606 intact-crc:97A74C935150795D|rigid:xEcQF51lQcmQmYEi9F+l0NfjNqY false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q01804 uniprotkb:P51570 intact:EBI-1054396|uniprotkb:Q147U2|uniprotkb:Q1ZYK1|uniprotkb:Q6PG39|uniprotkb:Q96MQ5|uniprotkb:Q9NT94|uniprotkb:Q9UPV6|uniprotkb:B4DYS4|ensembl:ENSP00000395487 intact:EBI-2269932|uniprotkb:B2RC07|intact:EBI-6190170|uniprotkb:B4E1G6|ensembl:ENSP00000225614|ensembl:ENSP00000465930 psi-mi:otud4_human(display_long)|uniprotkb:HIN-1(gene name synonym)|uniprotkb:HIV-1-induced protein HIN-1(gene name synonym)|uniprotkb:OTUD4(gene name)|psi-mi:OTUD4(display_short)|uniprotkb:KIAA1046(gene name synonym) psi-mi:galk1_human(display_long)|uniprotkb:GALK1(gene name)|psi-mi:GALK1(display_short)|uniprotkb:GALK(gene name synonym)|uniprotkb:Galactose kinase(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513303|imex:IM-12079-30 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_005263136.1|refseq:NP_001096123.1|refseq:NP_059963.1|ensembl:ENSG00000164164(gene)|ensembl:ENST00000447906(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0045087"(innate immune response)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061578"(Lys63-specific deubiquitinase activity)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:1901537"(positive regulation of DNA demethylation)|go:"GO:1903093"(regulation of protein K48-linked deubiquitination)|go:"GO:2000660"(negative regulation of interleukin-1-mediated signaling pathway)|interpro:IPR003323(Ovarian tumour, otubain)|interpro:IPR038765 go:"GO:0019388"(galactose catabolic process)|go:"GO:0019402"(galactitol metabolic process)|go:"GO:0061623"(glycolytic process from galactose)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000705(Galactokinase)|interpro:IPR006203(GHMP kinase, ATP-binding, conserved site)|interpro:IPR006204(GHMP kinase)|interpro:IPR006206(Mevalonate and galactokinase)|interpro:IPR013750(GHMP kinase, C-terminal)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR019539|interpro:IPR019741|interpro:IPR020568|interpro:IPR036554|mint:P51570|ensembl:ENSG00000108479(gene)|ensembl:ENST00000225614(transcript)|ensembl:ENST00000588479(transcript)|go:"GO:0004335"(galactokinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005534"(galactose binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006012"(galactose metabolic process)|go:"GO:0016020"(membrane)|rcsb pdb:1WUU|rcsb pdb:1YH7|rcsb pdb:6GR2|rcsb pdb:6Q3W|rcsb pdb:6Q3X|rcsb pdb:6Q8Z|rcsb pdb:6Q90|rcsb pdb:6Q91|rcsb pdb:6QJE|rcsb pdb:6ZFH|rcsb pdb:6ZGV|rcsb pdb:6ZGW|rcsb pdb:6ZGX|rcsb pdb:6ZGY|rcsb pdb:6ZGZ|reactome:R-HSA-5609976|reactome:R-HSA-70370 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:humMGfho0HKWE4zhO7+G00gIJfc9606 rogid:TtFcTQq+nspsst+xInA/huo/ZbU9606 intact-crc:97A74C935150795D|rigid:xEcQF51lQcmQmYEi9F+l0NfjNqY false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q01804 uniprotkb:P05787 intact:EBI-1054396|uniprotkb:Q147U2|uniprotkb:Q1ZYK1|uniprotkb:Q6PG39|uniprotkb:Q96MQ5|uniprotkb:Q9NT94|uniprotkb:Q9UPV6|uniprotkb:B4DYS4|ensembl:ENSP00000395487 intact:EBI-297852|uniprotkb:Q14099|uniprotkb:Q14716|uniprotkb:Q14717|uniprotkb:Q53GJ0|uniprotkb:Q6DHW5|uniprotkb:Q6GMY0|uniprotkb:Q6P4C7|uniprotkb:Q96J60|ensembl:ENSP00000293308|ensembl:ENSP00000447402|ensembl:ENSP00000447566|uniprotkb:A8K4H3|uniprotkb:B0AZN5|uniprotkb:F8VXB4 psi-mi:otud4_human(display_long)|uniprotkb:HIN-1(gene name synonym)|uniprotkb:HIV-1-induced protein HIN-1(gene name synonym)|uniprotkb:OTUD4(gene name)|psi-mi:OTUD4(display_short)|uniprotkb:KIAA1046(gene name synonym) psi-mi:k2c8_human(display_long)|uniprotkb:Keratin-8(gene name synonym)|uniprotkb:KRT8(gene name)|psi-mi:KRT8(display_short)|uniprotkb:CYK8(gene name synonym)|uniprotkb:Cytokeratin-8(gene name synonym)|uniprotkb:Type-II keratin Kb8(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513303|imex:IM-12079-30 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_005263136.1|refseq:NP_001096123.1|refseq:NP_059963.1|ensembl:ENSG00000164164(gene)|ensembl:ENST00000447906(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0045087"(innate immune response)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061578"(Lys63-specific deubiquitinase activity)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:1901537"(positive regulation of DNA demethylation)|go:"GO:1903093"(regulation of protein K48-linked deubiquitination)|go:"GO:2000660"(negative regulation of interleukin-1-mediated signaling pathway)|interpro:IPR003323(Ovarian tumour, otubain)|interpro:IPR038765 refseq:NP_001243222.1|ensembl:ENSG00000170421(gene)|ensembl:ENST00000293308(transcript)|ensembl:ENST00000546897(transcript)|ensembl:ENST00000552551(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005882"(intermediate filament)|go:"GO:0005911"(cell-cell junction)|go:"GO:0016010"(dystrophin-associated glycoprotein complex)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0016363"(nuclear matrix)|go:"GO:0030018"(Z disc)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0042383"(sarcolemma)|go:"GO:0043034"(costamere)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045095"(keratin filament)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045214"(sarcomere organization)|go:"GO:0051599"(response to hydrostatic pressure)|go:"GO:0051707"(response to other organism)|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|interpro:IPR003054(Type II keratin)|interpro:IPR018039|interpro:IPR032444|interpro:IPR039008|mint:P05787|reactome:R-HSA-6805567|reactome:R-HSA-6809371|refseq:NP_002264.1|dip:DIP-424N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:humMGfho0HKWE4zhO7+G00gIJfc9606 rogid:zyV8eOjx426ehjJYK4jsizORUws9606 intact-crc:97A74C935150795D|rigid:xEcQF51lQcmQmYEi9F+l0NfjNqY false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q01804 uniprotkb:Q02413 intact:EBI-1054396|uniprotkb:Q147U2|uniprotkb:Q1ZYK1|uniprotkb:Q6PG39|uniprotkb:Q96MQ5|uniprotkb:Q9NT94|uniprotkb:Q9UPV6|uniprotkb:B4DYS4|ensembl:ENSP00000395487 intact:EBI-1045757|intact:EBI-28968615|ensembl:ENSP00000257192|uniprotkb:B7Z845 psi-mi:otud4_human(display_long)|uniprotkb:HIN-1(gene name synonym)|uniprotkb:HIV-1-induced protein HIN-1(gene name synonym)|uniprotkb:OTUD4(gene name)|psi-mi:OTUD4(display_short)|uniprotkb:KIAA1046(gene name synonym) psi-mi:dsg1_human(display_long)|uniprotkb:CDHF4(gene name synonym)|uniprotkb:Desmosomal glycoprotein 1(gene name synonym)|uniprotkb:Pemphigus foliaceus antigen(gene name synonym)|uniprotkb:DSG1(gene name)|psi-mi:DSG1(display_short)|uniprotkb:Cadherin family member 4(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513303|imex:IM-12079-30 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_005263136.1|refseq:NP_001096123.1|refseq:NP_059963.1|ensembl:ENSG00000164164(gene)|ensembl:ENST00000447906(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0045087"(innate immune response)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061578"(Lys63-specific deubiquitinase activity)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:1901537"(positive regulation of DNA demethylation)|go:"GO:1903093"(regulation of protein K48-linked deubiquitination)|go:"GO:2000660"(negative regulation of interleukin-1-mediated signaling pathway)|interpro:IPR003323(Ovarian tumour, otubain)|interpro:IPR038765 ensembl:ENSP00000257192|refseq:NP_001933.2|ensembl:ENSG00000134760(gene)|ensembl:ENST00000257192(transcript)|go:"GO:0001533"(cornified envelope)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0015643"(toxic substance binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016339"(calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0030057"(desmosome)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0101003"(ficolin-1-rich granule membrane)|interpro:IPR000233(Cadherin cytoplasmic region)|interpro:IPR002126(Cadherin)|interpro:IPR009122(Desmosomal cadherin)|interpro:IPR009123(Desmoglein)|interpro:IPR015919(Cadherin-like)|interpro:IPR020894|interpro:IPR027397|mint:Q02413|reactome:R-HSA-351906|reactome:R-HSA-6798695|reactome:R-HSA-6805567|reactome:R-HSA-6809371|reactome:R-HSA-9696264|reactome:R-HSA-9696270 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:humMGfho0HKWE4zhO7+G00gIJfc9606 rogid:CiRFIJ9IWOol9bQpLJPxH8JArtE9606 intact-crc:97A74C935150795D|rigid:xEcQF51lQcmQmYEi9F+l0NfjNqY false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q01804 intact:EBI-1058964 intact:EBI-1054396|uniprotkb:Q147U2|uniprotkb:Q1ZYK1|uniprotkb:Q6PG39|uniprotkb:Q96MQ5|uniprotkb:Q9NT94|uniprotkb:Q9UPV6|uniprotkb:B4DYS4|ensembl:ENSP00000395487 intact:EBI-2269760 psi-mi:otud4_human(display_long)|uniprotkb:HIN-1(gene name synonym)|uniprotkb:HIV-1-induced protein HIN-1(gene name synonym)|uniprotkb:OTUD4(gene name)|psi-mi:OTUD4(display_short)|uniprotkb:KIAA1046(gene name synonym) psi-mi:hin1l_human(display_short)|psi-mi:EBI-1058964(display_long)|uniprotkb:HIN1L(gene name)|psi-mi:HIN1L(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513303|imex:IM-12079-30 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_005263136.1|refseq:NP_001096123.1|refseq:NP_059963.1|ensembl:ENSG00000164164(gene)|ensembl:ENST00000447906(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0045087"(innate immune response)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061578"(Lys63-specific deubiquitinase activity)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:1901537"(positive regulation of DNA demethylation)|go:"GO:1903093"(regulation of protein K48-linked deubiquitination)|go:"GO:2000660"(negative regulation of interleukin-1-mediated signaling pathway)|interpro:IPR003323(Ovarian tumour, otubain)|interpro:IPR038765 uniprotkb:Q7RTX8(uniprot-removed-ac) psi-mi:"MI:0469"(intact) - no-uniprot-update:|caution:The sequence has been withdrawn from uniprot. figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:humMGfho0HKWE4zhO7+G00gIJfc9606 rogid:Ee8LT4nBVNBeOm6geaphEcZqmGw9606 intact-crc:97A74C935150795D|rigid:xEcQF51lQcmQmYEi9F+l0NfjNqY false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q01804 uniprotkb:P25685 intact:EBI-1054396|uniprotkb:Q147U2|uniprotkb:Q1ZYK1|uniprotkb:Q6PG39|uniprotkb:Q96MQ5|uniprotkb:Q9NT94|uniprotkb:Q9UPV6|uniprotkb:B4DYS4|ensembl:ENSP00000395487 intact:EBI-357034|ensembl:ENSP00000254322|uniprotkb:B4DX52 psi-mi:otud4_human(display_long)|uniprotkb:HIN-1(gene name synonym)|uniprotkb:HIV-1-induced protein HIN-1(gene name synonym)|uniprotkb:OTUD4(gene name)|psi-mi:OTUD4(display_short)|uniprotkb:KIAA1046(gene name synonym) psi-mi:dnjb1_human(display_long)|uniprotkb:DNAJB1(gene name)|psi-mi:DNAJB1(display_short)|uniprotkb:DNAJ1(gene name synonym)|uniprotkb:HDJ1(gene name synonym)|uniprotkb:HSPF1(gene name synonym)|uniprotkb:Heat shock 40 kDa protein 1(gene name synonym)|uniprotkb:Human DnaJ protein 1(gene name synonym)|uniprotkb:DnaJ protein homolog 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513303|imex:IM-12079-30 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_005263136.1|refseq:NP_001096123.1|refseq:NP_059963.1|ensembl:ENSG00000164164(gene)|ensembl:ENST00000447906(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0045087"(innate immune response)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061578"(Lys63-specific deubiquitinase activity)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:1901537"(positive regulation of DNA demethylation)|go:"GO:1903093"(regulation of protein K48-linked deubiquitination)|go:"GO:2000660"(negative regulation of interleukin-1-mediated signaling pathway)|interpro:IPR003323(Ovarian tumour, otubain)|interpro:IPR038765 dip:DIP-41180N|ensembl:ENSG00000132002(gene)|ensembl:ENST00000254322(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0014069"(postsynaptic density)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030900"(forebrain development)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|refseq:NP_006136.1|refseq:XP_006722796.1|refseq:NP_001287843.1|refseq:NP_001300893.1|refseq:XP_011526258.1|refseq:XP_006722797.1|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045296"(cadherin binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0061827"(sperm head)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090084"(negative regulation of inclusion body assembly)|go:"GO:0097201"(negative regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900034"(regulation of cellular response to heat)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR002939(Chaperone DnaJ, C-terminal)|interpro:IPR018253|interpro:IPR036869|mint:P25685|rcsb pdb:1HDJ|rcsb pdb:2QLD|rcsb pdb:3AGX|rcsb pdb:3AGY|rcsb pdb:3AGZ|rcsb pdb:4WB7|rcsb pdb:6BYR|rcsb pdb:6WJF|rcsb pdb:6WJG|rcsb pdb:6Z5N|reactome:R-HSA-3371453|reactome:R-HSA-3371497|reactome:R-HSA-3371568|reactome:R-HSA-3371571|reactome:R-HSA-5687128|interpro:IPR008971(HSP40/DnaJ peptide-binding) psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:humMGfho0HKWE4zhO7+G00gIJfc9606 rogid:8NJHM7hHFc+zqulNiUM9UMxT/ws9606 intact-crc:97A74C935150795D|rigid:xEcQF51lQcmQmYEi9F+l0NfjNqY false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y5T5 uniprotkb:P11182 intact:EBI-2513357|uniprotkb:B3KN13|uniprotkb:Q53GP7|uniprotkb:B4DY37|uniprotkb:Q53HA0|uniprotkb:B4DFV8|uniprotkb:A8MU43|uniprotkb:Q8NEL3|uniprotkb:Q9H3E6|uniprotkb:Q5VKN8|uniprotkb:D3DSD9|ensembl:ENSP00000334808|ensembl:ENSP00000382858 intact:EBI-359002|uniprotkb:Q5VVL8|uniprotkb:B2R811|intact:EBI-1058407|ensembl:ENSP00000359151 psi-mi:ubp16_human(display_long)|uniprotkb:USP16(gene name)|psi-mi:USP16(display_short)|uniprotkb:Ubiquitin-specific-processing protease 16(gene name synonym)|uniprotkb:Deubiquitinating enzyme 16(gene name synonym)|uniprotkb:Ubiquitin-processing protease UBP-M(gene name synonym)|uniprotkb:MSTP039(orf name)|uniprotkb:Ubiquitin thioesterase 16(gene name synonym) psi-mi:odb2_human(display_long)|uniprotkb:DBT(gene name)|psi-mi:DBT(display_short)|uniprotkb:BCATE2(gene name synonym)|uniprotkb:"Dihydrolipoyllysine-residue (2-methylpropanoyl)transferase"(gene name synonym)|uniprotkb:Dihydrolipoamide branched chain transacylase(gene name synonym)|uniprotkb:Dihydrolipoamide acetyltransferase component of branched-chain alpha-keto acid dehydrogenase complex(gene name synonym)|uniprotkb:Branched-chain alpha-keto acid dehydrogenase complex component E2(gene name synonym)|uniprotkb:52 kDa mitochondrial autoantigen of primary biliary cirrhosis(gene name synonym)|uniprotkb:Branched chain 2-oxo-acid dehydrogenase complex component E2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513373|imex:IM-12079-81 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001001992.1|refseq:NP_001027582.1|refseq:NP_006438.1|ensembl:ENSG00000156256(gene)|ensembl:ENST00000334352(transcript)|ensembl:ENST00000399976(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016578"(histone deubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035522"(monoubiquitinated histone H2A deubiquitination)|go:"GO:0042393"(histone binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045901"(positive regulation of translational elongation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0051301"(cell division)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070537"(histone H2A K63-linked deubiquitination)|go:"GO:0140014"(mitotic nuclear division)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|refseq:XP_016883746.1|refseq:XP_016883747.1|refseq:XP_016883748.1|refseq:XP_016883749.1|refseq:XP_016883750.1|dip:DIP-53761N|interpro:IPR018200|interpro:IPR028889|interpro:IPR030849|interpro:IPR038765|rcsb pdb:2I50|reactome:R-HSA-5689880|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type) refseq:NP_001909.3|ensembl:ENSG00000137992(gene)|ensembl:ENST00000370132(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0005947"(mitochondrial alpha-ketoglutarate dehydrogenase complex)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016407"(acetyltransferase activity)|go:"GO:0031405"(lipoic acid binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0043754"("dihydrolipoyllysine-residue (2-methylpropanoyl)transferase activity")|interpro:IPR000089(Biotin/lipoyl attachment)|interpro:IPR001078(Catalytic domain of components of various dehydrogenase complexes)|interpro:IPR003016(2-oxo acid dehydrogenase, lipoyl-binding site)|interpro:IPR004167(E3 binding)|interpro:IPR011053(Single hybrid motif)|interpro:IPR023213|interpro:IPR036625|mint:P11182|rcsb pdb:1K8M|rcsb pdb:1K8O|rcsb pdb:1ZWV|rcsb pdb:2COO|rcsb pdb:3RNM|reactome:R-HSA-389661|reactome:R-HSA-70895|reactome:R-HSA-9013407 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:ParZH3MBA79ds8jMnIFj0tgS0aQ9606 rogid:Q+c6k43BrkvtPPFCOW5pfJltPsU9606 intact-crc:72837ACE61C784D9|rigid:omLyZ6MTySbytfAGMnCmeoQHEbs false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y5T5 uniprotkb:O95714 intact:EBI-2513357|uniprotkb:B3KN13|uniprotkb:Q53GP7|uniprotkb:B4DY37|uniprotkb:Q53HA0|uniprotkb:B4DFV8|uniprotkb:A8MU43|uniprotkb:Q8NEL3|uniprotkb:Q9H3E6|uniprotkb:Q5VKN8|uniprotkb:D3DSD9|ensembl:ENSP00000334808|ensembl:ENSP00000382858 intact:EBI-1058922|uniprotkb:Q86SV7|uniprotkb:Q86SV8|uniprotkb:Q86SV9|uniprotkb:Q86YY3|uniprotkb:Q86YY4|uniprotkb:Q86YY5|uniprotkb:Q86YY6|uniprotkb:Q86YY7|uniprotkb:Q86YY8|uniprotkb:Q86YY9|uniprotkb:Q86YZ0|uniprotkb:Q86YZ1|intact:EBI-1104961|intact:EBI-28977852|ensembl:ENSP00000261609 psi-mi:ubp16_human(display_long)|uniprotkb:USP16(gene name)|psi-mi:USP16(display_short)|uniprotkb:Ubiquitin-specific-processing protease 16(gene name synonym)|uniprotkb:Deubiquitinating enzyme 16(gene name synonym)|uniprotkb:Ubiquitin-processing protease UBP-M(gene name synonym)|uniprotkb:MSTP039(orf name)|uniprotkb:Ubiquitin thioesterase 16(gene name synonym) psi-mi:herc2_human(display_long)|uniprotkb:HERC2(gene name)|psi-mi:HERC2(display_short)|uniprotkb:HECT domain and RCC1-like domain-containing protein 2(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase HERC2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513373|imex:IM-12079-81 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001001992.1|refseq:NP_001027582.1|refseq:NP_006438.1|ensembl:ENSG00000156256(gene)|ensembl:ENST00000334352(transcript)|ensembl:ENST00000399976(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016578"(histone deubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035522"(monoubiquitinated histone H2A deubiquitination)|go:"GO:0042393"(histone binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045901"(positive regulation of translational elongation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0051301"(cell division)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070537"(histone H2A K63-linked deubiquitination)|go:"GO:0140014"(mitotic nuclear division)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|refseq:XP_016883746.1|refseq:XP_016883747.1|refseq:XP_016883748.1|refseq:XP_016883749.1|refseq:XP_016883750.1|dip:DIP-53761N|interpro:IPR018200|interpro:IPR028889|interpro:IPR030849|interpro:IPR038765|rcsb pdb:2I50|reactome:R-HSA-5689880|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type) ensembl:ENSP00000261609|refseq:NP_004658.3|ensembl:ENSG00000128731(gene)|ensembl:ENST00000261609(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006281"(DNA repair)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032183"(SUMO binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR000433(Zinc finger, ZZ-type)|interpro:IPR000569(HECT)|interpro:IPR001199(Cytochrome b5)|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR006624(Beta-propeller repeat TECPR)|interpro:IPR008979(Galactose-binding like)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR010606(Mib-herc2)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR021097|interpro:IPR035983|interpro:IPR036400|interpro:IPR037252|interpro:IPR037976|interpro:IPR041987|interpro:IPR043145|mint:O95714|rcsb pdb:2KEO|go:"GO:0031625"(ubiquitin protein ligase binding)|rcsb pdb:3KCI|rcsb pdb:4L1M|rcsb pdb:6WW4|reactome:R-HSA-3108214|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473|reactome:R-HSA-983168|rcsb pdb:6WW3|dip:DIP-37632N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:ParZH3MBA79ds8jMnIFj0tgS0aQ9606 rogid:ejMTmb0F9pM7zfHbRscV1rIRgSw9606 intact-crc:72837ACE61C784D9|rigid:omLyZ6MTySbytfAGMnCmeoQHEbs false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y5T5 uniprotkb:Q99880 intact:EBI-2513357|uniprotkb:B3KN13|uniprotkb:Q53GP7|uniprotkb:B4DY37|uniprotkb:Q53HA0|uniprotkb:B4DFV8|uniprotkb:A8MU43|uniprotkb:Q8NEL3|uniprotkb:Q9H3E6|uniprotkb:Q5VKN8|uniprotkb:D3DSD9|ensembl:ENSP00000334808|ensembl:ENSP00000382858 intact:EBI-1237119|uniprotkb:Q52LW9|uniprotkb:B2R5A3|ensembl:ENSP00000366618 psi-mi:ubp16_human(display_long)|uniprotkb:USP16(gene name)|psi-mi:USP16(display_short)|uniprotkb:Ubiquitin-specific-processing protease 16(gene name synonym)|uniprotkb:Deubiquitinating enzyme 16(gene name synonym)|uniprotkb:Ubiquitin-processing protease UBP-M(gene name synonym)|uniprotkb:MSTP039(orf name)|uniprotkb:Ubiquitin thioesterase 16(gene name synonym) psi-mi:h2b1l_human(display_long)|uniprotkb:H2BC13(gene name)|psi-mi:H2BC13(display_short)|uniprotkb:H2BFC(gene name synonym)|uniprotkb:HIST1H2BL(gene name synonym)|uniprotkb:Histone H2B.c(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513373|imex:IM-12079-81 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001001992.1|refseq:NP_001027582.1|refseq:NP_006438.1|ensembl:ENSG00000156256(gene)|ensembl:ENST00000334352(transcript)|ensembl:ENST00000399976(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016578"(histone deubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035522"(monoubiquitinated histone H2A deubiquitination)|go:"GO:0042393"(histone binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045901"(positive regulation of translational elongation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0051301"(cell division)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070537"(histone H2A K63-linked deubiquitination)|go:"GO:0140014"(mitotic nuclear division)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|refseq:XP_016883746.1|refseq:XP_016883747.1|refseq:XP_016883748.1|refseq:XP_016883749.1|refseq:XP_016883750.1|dip:DIP-53761N|interpro:IPR018200|interpro:IPR028889|interpro:IPR030849|interpro:IPR038765|rcsb pdb:2I50|reactome:R-HSA-5689880|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type) refseq:NP_003510.1|dip:DIP-38154N|interpro:IPR000558(Histone H2B)|interpro:IPR007125(Histone core)|ensembl:ENSG00000185130(gene)|ensembl:ENST00000377401(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070062"(extracellular exosome)|reactome:R-HSA-110328|reactome:R-HSA-110329|reactome:R-HSA-110330|reactome:R-HSA-110331|reactome:R-HSA-1221632|interpro:IPR009072(Histone-fold)|reactome:R-HSA-171306|reactome:R-HSA-1912408|reactome:R-HSA-201722|reactome:R-HSA-212300|reactome:R-HSA-2299718|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559586|reactome:R-HSA-3214815|reactome:R-HSA-3214847|reactome:R-HSA-427359|reactome:R-HSA-427389|reactome:R-HSA-427413|reactome:R-HSA-5334118|reactome:R-HSA-5578749|reactome:R-HSA-5617472|reactome:R-HSA-5250924|reactome:R-HSA-5625886|reactome:R-HSA-5689880|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-606279|reactome:R-HSA-69473|reactome:R-HSA-73728|reactome:R-HSA-73772|reactome:R-HSA-8866654|reactome:R-HSA-8936459|reactome:R-HSA-8939236|reactome:R-HSA-9018519|reactome:R-HSA-912446|reactome:R-HSA-9609690|reactome:R-HSA-9610379|reactome:R-HSA-9616222|reactome:R-HSA-9670095|reactome:R-HSA-9710421|reactome:R-HSA-977225 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:ParZH3MBA79ds8jMnIFj0tgS0aQ9606 rogid:vVD3xoHavMKCopzEez7zarZBKFc9606 intact-crc:72837ACE61C784D9|rigid:omLyZ6MTySbytfAGMnCmeoQHEbs false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y5T5 intact:EBI-2513370 intact:EBI-2513357|uniprotkb:B3KN13|uniprotkb:Q53GP7|uniprotkb:B4DY37|uniprotkb:Q53HA0|uniprotkb:B4DFV8|uniprotkb:A8MU43|uniprotkb:Q8NEL3|uniprotkb:Q9H3E6|uniprotkb:Q5VKN8|uniprotkb:D3DSD9|ensembl:ENSP00000334808|ensembl:ENSP00000382858 - psi-mi:ubp16_human(display_long)|uniprotkb:USP16(gene name)|psi-mi:USP16(display_short)|uniprotkb:Ubiquitin-specific-processing protease 16(gene name synonym)|uniprotkb:Deubiquitinating enzyme 16(gene name synonym)|uniprotkb:Ubiquitin-processing protease UBP-M(gene name synonym)|uniprotkb:MSTP039(orf name)|uniprotkb:Ubiquitin thioesterase 16(gene name synonym) psi-mi:a6nck6_human(display_short)|psi-mi:EBI-2513370(display_long) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513373|imex:IM-12079-81 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001001992.1|refseq:NP_001027582.1|refseq:NP_006438.1|ensembl:ENSG00000156256(gene)|ensembl:ENST00000334352(transcript)|ensembl:ENST00000399976(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016578"(histone deubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035522"(monoubiquitinated histone H2A deubiquitination)|go:"GO:0042393"(histone binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045901"(positive regulation of translational elongation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0051301"(cell division)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070537"(histone H2A K63-linked deubiquitination)|go:"GO:0140014"(mitotic nuclear division)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|refseq:XP_016883746.1|refseq:XP_016883747.1|refseq:XP_016883748.1|refseq:XP_016883749.1|refseq:XP_016883750.1|dip:DIP-53761N|interpro:IPR018200|interpro:IPR028889|interpro:IPR030849|interpro:IPR038765|rcsb pdb:2I50|reactome:R-HSA-5689880|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type) uniprotkb:A6NCK6(uniprot-removed-ac) psi-mi:"MI:0469"(intact) - no-uniprot-update:|caution:The sequence has been withdrawn from uniprot. figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:ParZH3MBA79ds8jMnIFj0tgS0aQ9606 rogid:0unjvgfvfA/849+ymm3gTcfOCRo9606 intact-crc:72837ACE61C784D9|rigid:omLyZ6MTySbytfAGMnCmeoQHEbs false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UHP3 uniprotkb:Q9UM54 intact:EBI-2513462|ensembl:ENSP00000285679|uniprotkb:Q9H9W1|uniprotkb:Q6DHZ9|uniprotkb:C0LSZ0 intact:EBI-350606|uniprotkb:Q5TEM5|uniprotkb:Q5TEM6|uniprotkb:Q5TEM7|uniprotkb:Q9BZZ7|uniprotkb:Q9UEG2|uniprotkb:A6H8V4|uniprotkb:E1P540 psi-mi:ubp25_human(display_long)|uniprotkb:USP25(gene name)|psi-mi:USP25(display_short)|uniprotkb:USP21(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 25(gene name synonym)|uniprotkb:Deubiquitinating enzyme 25(gene name synonym)|uniprotkb:USP on chromosome 21(gene name synonym)|uniprotkb:Ubiquitin thioesterase 25(gene name synonym) psi-mi:myo6_human(display_long)|uniprotkb:MYO6(gene name)|psi-mi:MYO6(display_short)|uniprotkb:KIAA0389(gene name synonym)|uniprotkb:Unconventional myosin-6(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513469|imex:IM-12079-82 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000155313(gene)|ensembl:ENST00000285679(transcript)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006508"(proteolysis)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008233"(peptidase activity)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019783"(ubiquitin-like protein-specific protease activity)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032183"(SUMO binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:1904293"(negative regulation of ERAD pathway)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR009060(UBA-like)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|rcsb pdb:2MUX|rcsb pdb:5GP7|rcsb pdb:5O71|rcsb pdb:6H4J|rcsb pdb:6H4K|rcsb pdb:6HEL|rcsb pdb:6HEM|reactome:R-HSA-5689880|refseq:NP_001269970.1|refseq:NP_001269971.1|refseq:NP_037528.3 go:"GO:0051046"(regulation of secretion)|refseq:NP_004990.3|go:"GO:0000146"(microfilament motor activity)|go:"GO:0001726"(ruffle)|go:"GO:0003774"(cytoskeletal motor activity)|go:"GO:0003779"(actin binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016461"(unconventional myosin complex)|go:"GO:0016591"(RNA polymerase II, holoenzyme)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0030050"(vesicle transport along actin filament)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030175"(filopodium)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0030665"(clathrin-coated vesicle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031941"(filamentous actin)|go:"GO:0031965"(nuclear membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032587"(ruffle membrane)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043531"(ADP binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051015"(actin filament binding)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005938"(cell cortex)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006897"(endocytosis)|go:"GO:0007015"(actin filament organization)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001609(Myosin head, motor region)|interpro:IPR004009(Myosin, N-terminal, SH3-like)|interpro:IPR008989(Myosin S1 fragment, N-terminal)|interpro:IPR027417|interpro:IPR032412|interpro:IPR036114|interpro:IPR036961|rcsb pdb:2N0Z|rcsb pdb:2N10|rcsb pdb:2N11|go:"GO:0060001"(minus-end directed microfilament motor activity)|rcsb pdb:2N12|rcsb pdb:2N13|rcsb pdb:6E5N|rcsb pdb:6J56|reactome:R-HSA-190873|reactome:R-HSA-399719|reactome:R-HSA-9013418|reactome:R-HSA-9013420|reactome:R-HSA-9013422|refseq:NP_001287828.1|mint:Q9UM54|dip:DIP-33123N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2020/03/02 rogid:PNngYJUduwx8fZiU1uDhAWYeZz49606 rogid:LYtnU7aRzVE/LDFhZgcK5IvahC09606 intact-crc:7484E4B2A570EFC8|rigid:WIzz4xOa88xf+gDErdD8fM1943o false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UHP3 uniprotkb:Q15843 intact:EBI-2513462|ensembl:ENSP00000285679|uniprotkb:Q9H9W1|uniprotkb:Q6DHZ9|uniprotkb:C0LSZ0 intact:EBI-716247|uniprotkb:Q3SXN8|uniprotkb:Q6LES6|ensembl:ENSP00000250495|ensembl:ENSP00000496420 psi-mi:ubp25_human(display_long)|uniprotkb:USP25(gene name)|psi-mi:USP25(display_short)|uniprotkb:USP21(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 25(gene name synonym)|uniprotkb:Deubiquitinating enzyme 25(gene name synonym)|uniprotkb:USP on chromosome 21(gene name synonym)|uniprotkb:Ubiquitin thioesterase 25(gene name synonym) psi-mi:nedd8_human(display_long)|uniprotkb:Ubiquitin-like protein Nedd8(gene name synonym)|uniprotkb:Neddylin(gene name synonym)|uniprotkb:Neural precursor cell expressed developmentally down-regulated protein 8(gene name synonym)|uniprotkb:NEDD8(gene name)|psi-mi:NEDD8(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513469|imex:IM-12079-82 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000155313(gene)|ensembl:ENST00000285679(transcript)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006508"(proteolysis)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008233"(peptidase activity)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019783"(ubiquitin-like protein-specific protease activity)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032183"(SUMO binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:1904293"(negative regulation of ERAD pathway)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR009060(UBA-like)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|rcsb pdb:2MUX|rcsb pdb:5GP7|rcsb pdb:5O71|rcsb pdb:6H4J|rcsb pdb:6H4K|rcsb pdb:6HEL|rcsb pdb:6HEM|reactome:R-HSA-5689880|refseq:NP_001269970.1|refseq:NP_001269971.1|refseq:NP_037528.3 refseq:NP_006147.1|ensembl:ENSG00000129559(gene)|ensembl:ENSG00000285246(gene)|ensembl:ENST00000250495(transcript)|ensembl:ENST00000643069(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006508"(proteolysis)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008104"(protein localization)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0019941"(modification-dependent protein catabolic process)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0031386"(protein tag)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0045116"(protein neddylation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000626(Ubiquitin)|interpro:IPR019954|interpro:IPR019956|interpro:IPR029071|interpro:IPR038738|mint:Q15843|rcsb pdb:1NDD|rcsb pdb:1R4M|rcsb pdb:1R4N|rcsb pdb:1XT9|rcsb pdb:2BKR|rcsb pdb:2KO3|rcsb pdb:2N7K|rcsb pdb:2NVU|rcsb pdb:3DBH|rcsb pdb:3DBL|rcsb pdb:3DBR|rcsb pdb:3DQV|rcsb pdb:3GZN|rcsb pdb:4F8C|rcsb pdb:4FBJ|rcsb pdb:4HCP|rcsb pdb:4P5O|rcsb pdb:6R7F|rcsb pdb:6R7I|rcsb pdb:6TTU|rcsb pdb:7B5L|rcsb pdb:7B5N|reactome:R-HSA-2173789|reactome:R-HSA-5689603|reactome:R-HSA-8856825|reactome:R-HSA-8951664|reactome:R-HSA-917937|dip:DIP-29266N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2020/03/02 rogid:PNngYJUduwx8fZiU1uDhAWYeZz49606 rogid:qB1KNoIOwa1ONfphWDWjJri9hwE9606 intact-crc:7484E4B2A570EFC8|rigid:WIzz4xOa88xf+gDErdD8fM1943o false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UHP3 uniprotkb:P04083 intact:EBI-2513462|ensembl:ENSP00000285679|uniprotkb:Q9H9W1|uniprotkb:Q6DHZ9|uniprotkb:C0LSZ0 intact:EBI-354007|ensembl:ENSP00000257497|ensembl:ENSP00000366109|uniprotkb:B5BU38 psi-mi:ubp25_human(display_long)|uniprotkb:USP25(gene name)|psi-mi:USP25(display_short)|uniprotkb:USP21(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 25(gene name synonym)|uniprotkb:Deubiquitinating enzyme 25(gene name synonym)|uniprotkb:USP on chromosome 21(gene name synonym)|uniprotkb:Ubiquitin thioesterase 25(gene name synonym) psi-mi:anxa1_human(display_long)|uniprotkb:ANXA1(gene name)|psi-mi:ANXA1(display_short)|uniprotkb:ANX1(gene name synonym)|uniprotkb:LPC1(gene name synonym)|uniprotkb:Annexin-1(gene name synonym)|uniprotkb:Annexin I(gene name synonym)|uniprotkb:Lipocortin I(gene name synonym)|uniprotkb:Calpactin II(gene name synonym)|uniprotkb:Chromobindin-9(gene name synonym)|uniprotkb:p35(gene name synonym)|uniprotkb:Phospholipase A2 inhibitory protein(gene name synonym)|uniprotkb:Calpactin-2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513469|imex:IM-12079-82 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000155313(gene)|ensembl:ENST00000285679(transcript)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006508"(proteolysis)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008233"(peptidase activity)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019783"(ubiquitin-like protein-specific protease activity)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032183"(SUMO binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:1904293"(negative regulation of ERAD pathway)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR009060(UBA-like)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|rcsb pdb:2MUX|rcsb pdb:5GP7|rcsb pdb:5O71|rcsb pdb:6H4J|rcsb pdb:6H4K|rcsb pdb:6HEL|rcsb pdb:6HEM|reactome:R-HSA-5689880|refseq:NP_001269970.1|refseq:NP_001269971.1|refseq:NP_037528.3 refseq:NP_000691.1|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0018149"(peptide cross-linking)|go:"GO:0019834"(phospholipase A2 inhibitor activity)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0030073"(insulin secretion)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030850"(prostate gland development)|go:"GO:0031018"(endocrine pancreas development)|go:"GO:0031232"(extrinsic component of external side of plasma membrane)|go:"GO:0031313"(extrinsic component of endosome membrane)|go:"GO:0031340"(positive regulation of vesicle fusion)|go:"GO:0031394"(positive regulation of prostaglandin biosynthetic process)|go:"GO:0031514"(motile cilium)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032355"(response to estradiol)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0032652"(regulation of interleukin-1 production)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033031"(positive regulation of neutrophil apoptotic process)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0036121"(double-stranded DNA helicase activity)|go:"GO:0042063"(gliogenesis)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0042493"|go:"GO:0042629"(mast cell granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045087"(innate immune response)|go:"GO:0045627"(positive regulation of T-helper 1 cell differentiation)|go:"GO:0045629"(negative regulation of T-helper 2 cell differentiation)|go:"GO:0045920"(negative regulation of exocytosis)|go:"GO:0046632"(alpha-beta T cell differentiation)|ensembl:ENSG00000135046(gene)|ensembl:ENST00000257497(transcript)|ensembl:ENST00000376911(transcript)|go:"GO:0001533"(cornified envelope)|go:"GO:0001780"(neutrophil homeostasis)|go:"GO:0001891"(phagocytic cup)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002685"(regulation of leukocyte migration)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005544"(calcium-dependent phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006909"(phagocytosis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009986"(cell surface)|go:"GO:0010165"(response to X-ray)|go:"GO:0014839"(myoblast migration involved in skeletal muscle regeneration)|go:"GO:0016323"(basolateral plasma membrane)|refseq:XP_011516911.1|dip:DIP-32875N|go:"GO:0046883"(regulation of hormone secretion)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070365"(hepatocyte differentiation)|go:"GO:0070459"(prolactin secretion)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0071385"(cellular response to glucocorticoid stimulus)|go:"GO:0071621"(granulocyte chemotaxis)|go:"GO:0090050"(positive regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097350"(neutrophil clearance)|go:"GO:0098641"(cadherin binding involved in cell-cell adhesion)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1900138"(negative regulation of phospholipase A2 activity)|go:"GO:1990814"(DNA/DNA annealing activity)|interpro:IPR001464(Annexin)|interpro:IPR002388(Annexin, type I)|interpro:IPR018252|interpro:IPR018502|interpro:IPR037104|mint:P04083|rcsb pdb:1AIN|rcsb pdb:1BO9|rcsb pdb:1QLS|rcsb pdb:5VFW|reactome:R-HSA-416476|reactome:R-HSA-418594|reactome:R-HSA-444473|reactome:R-HSA-445355|reactome:R-HSA-6785807|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0050482"(arachidonic acid secretion)|go:"GO:0050709"(negative regulation of protein secretion)|go:"GO:0050727"(regulation of inflammatory response) psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2020/03/02 rogid:PNngYJUduwx8fZiU1uDhAWYeZz49606 rogid:QKmqz+UsAof35B/so2qKLQjn2v09606 intact-crc:7484E4B2A570EFC8|rigid:WIzz4xOa88xf+gDErdD8fM1943o false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UHP3 uniprotkb:Q9H3F6 intact:EBI-2513462|ensembl:ENSP00000285679|uniprotkb:Q9H9W1|uniprotkb:Q6DHZ9|uniprotkb:C0LSZ0 intact:EBI-2505886|uniprotkb:Q53HN2|uniprotkb:Q59FV1|uniprotkb:Q6PL47|uniprotkb:Q96SU0|intact:EBI-2563423|ensembl:ENSP00000228495 psi-mi:ubp25_human(display_long)|uniprotkb:USP25(gene name)|psi-mi:USP25(display_short)|uniprotkb:USP21(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 25(gene name synonym)|uniprotkb:Deubiquitinating enzyme 25(gene name synonym)|uniprotkb:USP on chromosome 21(gene name synonym)|uniprotkb:Ubiquitin thioesterase 25(gene name synonym) psi-mi:bacd3_human(display_long)|uniprotkb:BTB/POZ domain-containing protein KCTD10(gene name synonym)|uniprotkb:Potassium channel tetramerization domain-containing protein 10(gene name synonym)|uniprotkb:KCTD10(gene name)|psi-mi:KCTD10(display_short)|uniprotkb:ULR061(gene name synonym)|uniprotkb:MSTP028(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513469|imex:IM-12079-82 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000155313(gene)|ensembl:ENST00000285679(transcript)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006508"(proteolysis)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008233"(peptidase activity)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019783"(ubiquitin-like protein-specific protease activity)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032183"(SUMO binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:1904293"(negative regulation of ERAD pathway)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR009060(UBA-like)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|rcsb pdb:2MUX|rcsb pdb:5GP7|rcsb pdb:5O71|rcsb pdb:6H4J|rcsb pdb:6H4K|rcsb pdb:6HEL|rcsb pdb:6HEM|reactome:R-HSA-5689880|refseq:NP_001269970.1|refseq:NP_001269971.1|refseq:NP_037528.3 refseq:NP_001304324.1|refseq:NP_001304328.1|refseq:NP_114160.1|ensembl:ENSG00000110906(gene)|ensembl:ENST00000228495(transcript)|go:"GO:0005112"(Notch binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0051260"(protein homooligomerization)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR003131(Potassium channel, voltage dependent, Kv, tetramerisation)|interpro:IPR011333(BTB/POZ fold)|rcsb pdb:5FTA psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2020/03/02 rogid:PNngYJUduwx8fZiU1uDhAWYeZz49606 rogid:ol+Pl17F/3aoKl1CD+edgT9KweI9606 intact-crc:7484E4B2A570EFC8|rigid:WIzz4xOa88xf+gDErdD8fM1943o false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UHP3 uniprotkb:Q96RU2 intact:EBI-2513462|ensembl:ENSP00000285679|uniprotkb:Q9H9W1|uniprotkb:Q6DHZ9|uniprotkb:C0LSZ0 intact:EBI-2512342|ensembl:ENSP00000003302|uniprotkb:B0YJC0|uniprotkb:B0YJC1|uniprotkb:Q9P213|intact:EBI-2796288|uniprotkb:Q6NZX9 psi-mi:ubp25_human(display_long)|uniprotkb:USP25(gene name)|psi-mi:USP25(display_short)|uniprotkb:USP21(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 25(gene name synonym)|uniprotkb:Deubiquitinating enzyme 25(gene name synonym)|uniprotkb:USP on chromosome 21(gene name synonym)|uniprotkb:Ubiquitin thioesterase 25(gene name synonym) psi-mi:ubp28_human(display_long)|uniprotkb:USP28(gene name)|psi-mi:USP28(display_short)|uniprotkb:KIAA1515(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 28(gene name synonym)|uniprotkb:Deubiquitinating enzyme 28(gene name synonym)|uniprotkb:Ubiquitin thioesterase 28(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513469|imex:IM-12079-82 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000155313(gene)|ensembl:ENST00000285679(transcript)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006508"(proteolysis)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008233"(peptidase activity)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019783"(ubiquitin-like protein-specific protease activity)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032183"(SUMO binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:1904293"(negative regulation of ERAD pathway)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR009060(UBA-like)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|rcsb pdb:2MUX|rcsb pdb:5GP7|rcsb pdb:5O71|rcsb pdb:6H4J|rcsb pdb:6H4K|rcsb pdb:6HEL|rcsb pdb:6HEM|reactome:R-HSA-5689880|refseq:NP_001269970.1|refseq:NP_001269971.1|refseq:NP_037528.3 ensembl:ENSG00000048028(gene)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008283"(cell population proliferation)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034644"(cellular response to UV)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR009060(UBA-like)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|mint:Q96RU2|rcsb pdb:2LVA|rcsb pdb:2MUU|rcsb pdb:6H4H|rcsb pdb:6H4I|rcsb pdb:6HEH|rcsb pdb:6HEI|rcsb pdb:6HEJ|rcsb pdb:6HEK|reactome:R-HSA-5689880|ensembl:ENST00000003302(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|refseq:NP_065937.1|refseq:NP_001333187.1|refseq:NP_001333202.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2020/03/02 rogid:PNngYJUduwx8fZiU1uDhAWYeZz49606 rogid:axlPKHiS0KlPbl2dNx2h12/LtY09606 intact-crc:7484E4B2A570EFC8|rigid:WIzz4xOa88xf+gDErdD8fM1943o false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UHP3 uniprotkb:Q96DA0 intact:EBI-2513462|ensembl:ENSP00000285679|uniprotkb:Q9H9W1|uniprotkb:Q6DHZ9|uniprotkb:C0LSZ0 intact:EBI-953824|ensembl:ENSP00000371715|ensembl:ENSP00000489035|uniprotkb:A6NIY1|uniprotkb:Q6UW28|uniprotkb:B2R4F6 psi-mi:ubp25_human(display_long)|uniprotkb:USP25(gene name)|psi-mi:USP25(display_short)|uniprotkb:USP21(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 25(gene name synonym)|uniprotkb:Deubiquitinating enzyme 25(gene name synonym)|uniprotkb:USP on chromosome 21(gene name synonym)|uniprotkb:Ubiquitin thioesterase 25(gene name synonym) psi-mi:zg16b_human(display_long)|uniprotkb:ZG16B(gene name)|psi-mi:ZG16B(display_short)|uniprotkb:UNQ773/PRO1567(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513469|imex:IM-12079-82 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000155313(gene)|ensembl:ENST00000285679(transcript)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006508"(proteolysis)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008233"(peptidase activity)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019783"(ubiquitin-like protein-specific protease activity)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032183"(SUMO binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:1904293"(negative regulation of ERAD pathway)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR009060(UBA-like)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|rcsb pdb:2MUX|rcsb pdb:5GP7|rcsb pdb:5O71|rcsb pdb:6H4J|rcsb pdb:6H4K|rcsb pdb:6HEL|rcsb pdb:6HEM|reactome:R-HSA-5689880|refseq:NP_001269970.1|refseq:NP_001269971.1|refseq:NP_037528.3 ensembl:ENST00000634500(transcript)|go:"GO:0001895"(retina homeostasis)|go:"GO:0005615"(extracellular space)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001229(Mannose-binding lectin)|interpro:IPR036404|rcsb pdb:3AQG|ensembl:ENSG00000283056(gene)|ensembl:ENST00000382280(transcript)|ensembl:ENSG00000162078(gene)|refseq:NP_660295.2 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2020/03/02 rogid:PNngYJUduwx8fZiU1uDhAWYeZz49606 rogid:0ymcb/0tSgZXhYQ6xHNIYrx9F3g9606 intact-crc:7484E4B2A570EFC8|rigid:WIzz4xOa88xf+gDErdD8fM1943o false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UHP3 uniprotkb:P12273 intact:EBI-2513462|ensembl:ENSP00000285679|uniprotkb:Q9H9W1|uniprotkb:Q6DHZ9|uniprotkb:C0LSZ0 intact:EBI-1049746|uniprotkb:A0A963|uniprotkb:A0A9C3|uniprotkb:A0A9F3|uniprotkb:A4D2I1|ensembl:ENSP00000291009 psi-mi:ubp25_human(display_long)|uniprotkb:USP25(gene name)|psi-mi:USP25(display_short)|uniprotkb:USP21(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 25(gene name synonym)|uniprotkb:Deubiquitinating enzyme 25(gene name synonym)|uniprotkb:USP on chromosome 21(gene name synonym)|uniprotkb:Ubiquitin thioesterase 25(gene name synonym) psi-mi:pip_human(display_long)|uniprotkb:Prolactin-induced protein(gene name synonym)|uniprotkb:Secretory actin-binding protein(gene name synonym)|uniprotkb:Gross cystic disease fluid protein 15(gene name synonym)|uniprotkb:gp17(gene name synonym)|uniprotkb:PIP(gene name)|psi-mi:PIP(display_short)|uniprotkb:GCDFP15(gene name synonym)|uniprotkb:GPIP4(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513469|imex:IM-12079-82 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000155313(gene)|ensembl:ENST00000285679(transcript)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006508"(proteolysis)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008233"(peptidase activity)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019783"(ubiquitin-like protein-specific protease activity)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032183"(SUMO binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:1904293"(negative regulation of ERAD pathway)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR009060(UBA-like)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|rcsb pdb:2MUX|rcsb pdb:5GP7|rcsb pdb:5O71|rcsb pdb:6H4J|rcsb pdb:6H4K|rcsb pdb:6HEL|rcsb pdb:6HEM|reactome:R-HSA-5689880|refseq:NP_001269970.1|refseq:NP_001269971.1|refseq:NP_037528.3 refseq:NP_002643.1|ensembl:ENSG00000159763(gene)|ensembl:ENST00000291009(transcript)|go:"GO:0001895"(retina homeostasis)|go:"GO:0002682"(regulation of immune system process)|go:"GO:0003779"(actin binding)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0006508"(proteolysis)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019864"(IgG binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070233"(negative regulation of T cell apoptotic process)|interpro:IPR007990(Seminal vesicle autoantigen)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|mint:P12273|rcsb pdb:3ES6|reactome:R-HSA-5223345|go:"GO:0001580"(detection of chemical stimulus involved in sensory perception of bitter taste) psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2020/03/02 rogid:PNngYJUduwx8fZiU1uDhAWYeZz49606 rogid:/OC16zeRzFp520uPPLHh+WekPPc9606 intact-crc:7484E4B2A570EFC8|rigid:WIzz4xOa88xf+gDErdD8fM1943o false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UHP3 uniprotkb:Q96S55 intact:EBI-2513462|ensembl:ENSP00000285679|uniprotkb:Q9H9W1|uniprotkb:Q6DHZ9|uniprotkb:C0LSZ0 intact:EBI-2513471|ensembl:ENSP00000370150|ensembl:ENSP00000477551|uniprotkb:Q9NRJ6|uniprotkb:Q5W0E2|uniprotkb:Q53EP6|uniprotkb:Q8WV26|uniprotkb:Q5W0E4|uniprotkb:Q59ET8|uniprotkb:Q9H681|uniprotkb:B2RDB0 psi-mi:ubp25_human(display_long)|uniprotkb:USP25(gene name)|psi-mi:USP25(display_short)|uniprotkb:USP21(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 25(gene name synonym)|uniprotkb:Deubiquitinating enzyme 25(gene name synonym)|uniprotkb:USP on chromosome 21(gene name synonym)|uniprotkb:Ubiquitin thioesterase 25(gene name synonym) psi-mi:wrip1_human(display_long)|uniprotkb:WRNIP1(gene name)|psi-mi:WRNIP1(display_short)|uniprotkb:WHIP(gene name synonym)|uniprotkb:Werner helicase-interacting protein 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513469|imex:IM-12079-82 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000155313(gene)|ensembl:ENST00000285679(transcript)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006508"(proteolysis)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008233"(peptidase activity)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019783"(ubiquitin-like protein-specific protease activity)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032183"(SUMO binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:1904293"(negative regulation of ERAD pathway)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR009060(UBA-like)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|rcsb pdb:2MUX|rcsb pdb:5GP7|rcsb pdb:5O71|rcsb pdb:6H4J|rcsb pdb:6H4K|rcsb pdb:6HEL|rcsb pdb:6HEM|reactome:R-HSA-5689880|refseq:NP_001269970.1|refseq:NP_001269971.1|refseq:NP_037528.3 ensembl:ENSG00000124535(gene)|ensembl:ENST00000380773(transcript)|ensembl:ENST00000618555(transcript)|go:"GO:0000731"(DNA synthesis involved in DNA repair)|go:"GO:0003677"(DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0016020"(membrane)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0030174"(regulation of DNA-dependent DNA replication initiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0045087"(innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR006642(Zinc finger, Rad18-type putative)|interpro:IPR008921(DNA polymerase III clamp loader subunit, C-terminal)|interpro:IPR021886|interpro:IPR027417|interpro:IPR032423|interpro:IPR040539|mint:Q96S55|rcsb pdb:3VHS|rcsb pdb:3VHT|go:"GO:0017116"(single-stranded DNA helicase activity)|refseq:NP_064520.2|refseq:NP_569079.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2020/03/02 rogid:PNngYJUduwx8fZiU1uDhAWYeZz49606 rogid:Q8qVSqItgTO7sbWGAQ3XAoFFUr89606 intact-crc:7484E4B2A570EFC8|rigid:WIzz4xOa88xf+gDErdD8fM1943o false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UHP3 uniprotkb:Q8WZ19 intact:EBI-2513462|ensembl:ENSP00000285679|uniprotkb:Q9H9W1|uniprotkb:Q6DHZ9|uniprotkb:C0LSZ0 intact:EBI-742916|ensembl:ENSP00000311202|ensembl:ENSP00000455785|uniprotkb:Q96P93|uniprotkb:Q96SA1|uniprotkb:A8K0R5 psi-mi:ubp25_human(display_long)|uniprotkb:USP25(gene name)|psi-mi:USP25(display_short)|uniprotkb:USP21(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 25(gene name synonym)|uniprotkb:Deubiquitinating enzyme 25(gene name synonym)|uniprotkb:USP on chromosome 21(gene name synonym)|uniprotkb:Ubiquitin thioesterase 25(gene name synonym) psi-mi:bacd1_human(display_long)|uniprotkb:Polymerase delta-interacting protein 1(gene name synonym)|uniprotkb:TNFAIP1-like protein(gene name synonym)|uniprotkb:KCTD13(gene name)|psi-mi:KCTD13(display_short)|uniprotkb:PDIP1(gene name synonym)|uniprotkb:POLDIP1(gene name synonym)|uniprotkb:FKSG86(orf name)|uniprotkb:PP6832(orf name)|uniprotkb:BACURD1(gene name synonym)|uniprotkb:BTB/POZ domain-containing protein KCTD13(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513469|imex:IM-12079-82 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000155313(gene)|ensembl:ENST00000285679(transcript)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006508"(proteolysis)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008233"(peptidase activity)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019783"(ubiquitin-like protein-specific protease activity)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032183"(SUMO binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:1904293"(negative regulation of ERAD pathway)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR009060(UBA-like)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|rcsb pdb:2MUX|rcsb pdb:5GP7|rcsb pdb:5O71|rcsb pdb:6H4J|rcsb pdb:6H4K|rcsb pdb:6HEL|rcsb pdb:6HEM|reactome:R-HSA-5689880|refseq:NP_001269970.1|refseq:NP_001269971.1|refseq:NP_037528.3 refseq:NP_849194.1|ensembl:ENSG00000174943(gene)|ensembl:ENST00000308768(transcript)|ensembl:ENST00000568000(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016477"(cell migration)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051260"(protein homooligomerization)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR003131(Potassium channel, voltage dependent, Kv, tetramerisation)|interpro:IPR011333(BTB/POZ fold)|mint:Q8WZ19|rcsb pdb:4UIJ|reactome:R-HSA-9696264|reactome:R-HSA-9696270 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2020/03/02 rogid:PNngYJUduwx8fZiU1uDhAWYeZz49606 rogid:hAH5yJEoda0H1anmnSXWHO0o1ZM9606 intact-crc:7484E4B2A570EFC8|rigid:WIzz4xOa88xf+gDErdD8fM1943o false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UHP3 uniprotkb:Q9P2J3 intact:EBI-2513462|ensembl:ENSP00000285679|uniprotkb:Q9H9W1|uniprotkb:Q6DHZ9|uniprotkb:C0LSZ0 intact:EBI-2510152|ensembl:ENSP00000351933|uniprotkb:Q8TCQ2 psi-mi:ubp25_human(display_long)|uniprotkb:USP25(gene name)|psi-mi:USP25(display_short)|uniprotkb:USP21(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 25(gene name synonym)|uniprotkb:Deubiquitinating enzyme 25(gene name synonym)|uniprotkb:USP on chromosome 21(gene name synonym)|uniprotkb:Ubiquitin thioesterase 25(gene name synonym) psi-mi:klhl9_human(display_long)|uniprotkb:KLHL9(gene name)|psi-mi:KLHL9(display_short)|uniprotkb:KIAA1354(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513469|imex:IM-12079-82 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000155313(gene)|ensembl:ENST00000285679(transcript)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006508"(proteolysis)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008233"(peptidase activity)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019783"(ubiquitin-like protein-specific protease activity)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032183"(SUMO binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:1904293"(negative regulation of ERAD pathway)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR009060(UBA-like)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|rcsb pdb:2MUX|rcsb pdb:5GP7|rcsb pdb:5O71|rcsb pdb:6H4J|rcsb pdb:6H4K|rcsb pdb:6HEL|rcsb pdb:6HEM|reactome:R-HSA-5689880|refseq:NP_001269970.1|refseq:NP_001269971.1|refseq:NP_037528.3 ensembl:ENSG00000198642(gene)|ensembl:ENST00000359039(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0007049"(cell cycle)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030496"(midbody)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0051301"(cell division)|go:"GO:0097602"(cullin family protein binding)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR011705(BTB/Kelch-associated)|interpro:IPR015915(Kelch-type beta propeller)|interpro:IPR017096(Kelch-like protein, gigaxonin)|reactome:R-HSA-8951664|reactome:R-HSA-983168|refseq:NP_061335.1|dip:DIP-53514N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2020/03/02 rogid:PNngYJUduwx8fZiU1uDhAWYeZz49606 rogid:BBlUawWo6f4qKrbRHeZp87E+DTo9606 intact-crc:7484E4B2A570EFC8|rigid:WIzz4xOa88xf+gDErdD8fM1943o false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UHP3 uniprotkb:P61626 intact:EBI-2513462|ensembl:ENSP00000285679|uniprotkb:Q9H9W1|uniprotkb:Q6DHZ9|uniprotkb:C0LSZ0 intact:EBI-355360|ensembl:ENSP00000261267|uniprotkb:P00695|uniprotkb:Q9UCF8|uniprotkb:Q13170 psi-mi:ubp25_human(display_long)|uniprotkb:USP25(gene name)|psi-mi:USP25(display_short)|uniprotkb:USP21(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 25(gene name synonym)|uniprotkb:Deubiquitinating enzyme 25(gene name synonym)|uniprotkb:USP on chromosome 21(gene name synonym)|uniprotkb:Ubiquitin thioesterase 25(gene name synonym) psi-mi:lysc_human(display_long)|uniprotkb:LYZ(gene name)|psi-mi:LYZ(display_short)|uniprotkb:LZM(gene name synonym)|uniprotkb:1,4-beta-N-acetylmuramidase C(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513469|imex:IM-12079-82 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000155313(gene)|ensembl:ENST00000285679(transcript)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006508"(proteolysis)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008233"(peptidase activity)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019783"(ubiquitin-like protein-specific protease activity)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032183"(SUMO binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:1904293"(negative regulation of ERAD pathway)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR009060(UBA-like)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|rcsb pdb:2MUX|rcsb pdb:5GP7|rcsb pdb:5O71|rcsb pdb:6H4J|rcsb pdb:6H4K|rcsb pdb:6HEL|rcsb pdb:6HEM|reactome:R-HSA-5689880|refseq:NP_001269970.1|refseq:NP_001269971.1|refseq:NP_037528.3 ensembl:ENSG00000090382(gene)|refseq:NP_000230.1|rcsb pdb:1GB7|rcsb pdb:1GB8|rcsb pdb:1GB9|rcsb pdb:1GBO|rcsb pdb:1GBW|rcsb pdb:1GBX|rcsb pdb:1GBY|rcsb pdb:1GBZ|rcsb pdb:1GDW|rcsb pdb:1GDX|rcsb pdb:1GE0|rcsb pdb:1GE1|rcsb pdb:1GE2|rcsb pdb:1GE3|rcsb pdb:1GE4|rcsb pdb:1GEV|rcsb pdb:1GEZ|rcsb pdb:1GF0|rcsb pdb:1GF3|rcsb pdb:1GF4|rcsb pdb:1GF5|rcsb pdb:1GF6|rcsb pdb:1GF7|rcsb pdb:1GF8|rcsb pdb:1GF9|rcsb pdb:1GFA|rcsb pdb:1GFE|rcsb pdb:1GFG|rcsb pdb:1GFH|rcsb pdb:1GFJ|rcsb pdb:1GFK|rcsb pdb:1GFR|rcsb pdb:1GFT|rcsb pdb:1GFU|rcsb pdb:1GFV|rcsb pdb:1HNL|rcsb pdb:1I1Z|rcsb pdb:1I20|rcsb pdb:1I22|rcsb pdb:1INU|rcsb pdb:1IOC|rcsb pdb:1IP1|rcsb pdb:1IP2|rcsb pdb:1IP3|rcsb pdb:1IP4|rcsb pdb:1IP5|rcsb pdb:1IP6|rcsb pdb:1IP7|rcsb pdb:1IWT|rcsb pdb:1IWU|rcsb pdb:1IWV|rcsb pdb:1IWW|rcsb pdb:1IWX|rcsb pdb:1IWY|rcsb pdb:1IWZ|rcsb pdb:1IX0|rcsb pdb:1IY3|rcsb pdb:1IY4|rcsb pdb:1JKA|rcsb pdb:1JKB|rcsb pdb:1JKC|rcsb pdb:1JKD|rcsb pdb:1JSF|rcsb pdb:1JWR|rcsb pdb:1LAA|rcsb pdb:1LHH|rcsb pdb:1LHI|rcsb pdb:1LHJ|rcsb pdb:1LHK|rcsb pdb:1LHL|rcsb pdb:1LHM|rcsb pdb:1LMT|rcsb pdb:1LOZ|rcsb pdb:1LYY|rcsb pdb:1LZ1|rcsb pdb:1LZ4|rcsb pdb:1LZ5|rcsb pdb:1LZ6|rcsb pdb:1LZR|rcsb pdb:1LZS|rcsb pdb:1OP9|rcsb pdb:1OUA|rcsb pdb:1OUB|rcsb pdb:1OUC|rcsb pdb:1OUD|rcsb pdb:1OUE|rcsb pdb:1OUF|rcsb pdb:1OUG|rcsb pdb:1OUH|rcsb pdb:1OUI|rcsb pdb:1OUJ|rcsb pdb:1QSW|rcsb pdb:1RE2|rcsb pdb:1REM|rcsb pdb:1REX|rcsb pdb:1REY|rcsb pdb:1REZ|rcsb pdb:1TAY|rcsb pdb:1TBY|rcsb pdb:1TCY|rcsb pdb:1TDY|rcsb pdb:1UBZ|rcsb pdb:5LVK|rcsb pdb:6LFH|reactome:R-HSA-6798695|reactome:R-HSA-6803157|reactome:R-HSA-977225|rcsb pdb:1W08|rcsb pdb:1WQM|rcsb pdb:1WQN|rcsb pdb:1WQO|rcsb pdb:1WQP|rcsb pdb:1WQQ|rcsb pdb:1WQR|rcsb pdb:1YAM|rcsb pdb:1YAN|rcsb pdb:1YAO|rcsb pdb:1YAP|rcsb pdb:1YAQ|rcsb pdb:207L|rcsb pdb:208L|rcsb pdb:2BQA|rcsb pdb:2BQB|rcsb pdb:2BQC|rcsb pdb:2BQD|rcsb pdb:2BQE|rcsb pdb:2BQF|rcsb pdb:2BQG|rcsb pdb:2BQH|rcsb pdb:2BQI|rcsb pdb:2BQJ|rcsb pdb:2BQK|rcsb pdb:2BQL|rcsb pdb:2BQM|rcsb pdb:2BQN|rcsb pdb:2BQO|rcsb pdb:2HEA|rcsb pdb:2HEB|rcsb pdb:2HEC|rcsb pdb:2HED|rcsb pdb:2HEE|rcsb pdb:2HEF|rcsb pdb:2LHM|rcsb pdb:2MEA|rcsb pdb:2MEB|rcsb pdb:2MEC|rcsb pdb:2MED|rcsb pdb:2MEE|rcsb pdb:2MEF|rcsb pdb:2MEG|rcsb pdb:2MEH|rcsb pdb:2MEI|rcsb pdb:2NWD|rcsb pdb:2ZIJ|rcsb pdb:2ZIK|rcsb pdb:2ZIL|rcsb pdb:2ZWB|rcsb pdb:3EBA|rcsb pdb:3FE0|rcsb pdb:3LHM|rcsb pdb:3LN2|rcsb pdb:4I0C|rcsb pdb:4ML7|rcsb pdb:4R0P|rcsb pdb:5LSH|rcsb pdb:1B5X|rcsb pdb:1B5Y|rcsb pdb:1B5Z|rcsb pdb:1B7L|rcsb pdb:1B7M|rcsb pdb:1B7N|rcsb pdb:1B7O|rcsb pdb:1B7P|rcsb pdb:1B7Q|rcsb pdb:1B7R|rcsb pdb:1B7S|rcsb pdb:1BB3|rcsb pdb:1BB4|rcsb pdb:1BB5|rcsb pdb:1C43|rcsb pdb:1C45|rcsb pdb:1C46|rcsb pdb:1C7P|rcsb pdb:1CJ6|rcsb pdb:1CJ7|rcsb pdb:1CJ8|ensembl:ENST00000261267(transcript)|go:"GO:0001895"(retina homeostasis)|go:"GO:0003796"(lysozyme activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0008152"(metabolic process)|go:"GO:0019730"(antimicrobial humoral response)|go:"GO:0019835"(cytolysis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0035580"(specific granule lumen)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904724"(tertiary granule lumen)|interpro:IPR000974(Glycoside hydrolase, family 22, lysozyme)|interpro:IPR001916(Glycoside hydrolase, family 22)|interpro:IPR019799|interpro:IPR023346|interpro:IPR030056|mint:P61626|rcsb pdb:133L|rcsb pdb:134L|rcsb pdb:1B5U|rcsb pdb:1B5V|rcsb pdb:1B5W|rcsb pdb:1CJ9|rcsb pdb:1CKC|rcsb pdb:1CKD|rcsb pdb:1CKF|rcsb pdb:1CKG|rcsb pdb:1CKH|rcsb pdb:1D6P|rcsb pdb:1D6Q|rcsb pdb:1DI3|rcsb pdb:1DI4|rcsb pdb:1DI5|rcsb pdb:1EQ4|rcsb pdb:1EQ5|rcsb pdb:1EQE|rcsb pdb:1GAY|rcsb pdb:1GAZ|rcsb pdb:1GB0|rcsb pdb:1GB2|rcsb pdb:1GB3|rcsb pdb:1GB5|rcsb pdb:1GB6 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2020/03/02 rogid:PNngYJUduwx8fZiU1uDhAWYeZz49606 rogid:jydNN9yuU9EYvnth+kv115svRxw9606 intact-crc:7484E4B2A570EFC8|rigid:WIzz4xOa88xf+gDErdD8fM1943o false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UHP3 uniprotkb:P19013 intact:EBI-2513462|ensembl:ENSP00000285679|uniprotkb:Q9H9W1|uniprotkb:Q6DHZ9|uniprotkb:C0LSZ0 intact:EBI-2371606|uniprotkb:Q6GTR8|uniprotkb:Q96LA7|uniprotkb:Q9BTL1|intact:EBI-22121113|uniprotkb:B4DRS2|uniprotkb:F8VS64|intact:EBI-22010019|intact:EBI-28973341|ensembl:ENSP00000448220 psi-mi:ubp25_human(display_long)|uniprotkb:USP25(gene name)|psi-mi:USP25(display_short)|uniprotkb:USP21(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 25(gene name synonym)|uniprotkb:Deubiquitinating enzyme 25(gene name synonym)|uniprotkb:USP on chromosome 21(gene name synonym)|uniprotkb:Ubiquitin thioesterase 25(gene name synonym) psi-mi:k2c4_human(display_long)|uniprotkb:KRT4(gene name)|psi-mi:KRT4(display_short)|uniprotkb:CYK4(gene name synonym)|uniprotkb:Cytokeratin-4(gene name synonym)|uniprotkb:Keratin-4(gene name synonym)|uniprotkb:Type-II keratin Kb4(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513469|imex:IM-12079-82 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000155313(gene)|ensembl:ENST00000285679(transcript)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006508"(proteolysis)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008233"(peptidase activity)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019783"(ubiquitin-like protein-specific protease activity)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032183"(SUMO binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:1904293"(negative regulation of ERAD pathway)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR009060(UBA-like)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|rcsb pdb:2MUX|rcsb pdb:5GP7|rcsb pdb:5O71|rcsb pdb:6H4J|rcsb pdb:6H4K|rcsb pdb:6HEL|rcsb pdb:6HEM|reactome:R-HSA-5689880|refseq:NP_001269970.1|refseq:NP_001269971.1|refseq:NP_037528.3 ensembl:ENSP00000448220|refseq:NP_002263.3|ensembl:ENSG00000170477(gene)|ensembl:ENST00000551956(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005882"(intermediate filament)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0009986"(cell surface)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0045095"(keratin filament)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|interpro:IPR003054(Type II keratin)|interpro:IPR018039|interpro:IPR032444|interpro:IPR039008|mint:P19013|reactome:R-HSA-6805567|reactome:R-HSA-6809371 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2020/03/02 rogid:PNngYJUduwx8fZiU1uDhAWYeZz49606 rogid:WBLRjdlqvNYbC7R2ZSNON6QLcOU9606 intact-crc:7484E4B2A570EFC8|rigid:WIzz4xOa88xf+gDErdD8fM1943o false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UHP3 uniprotkb:Q96Q07 intact:EBI-2513462|ensembl:ENSP00000285679|uniprotkb:Q9H9W1|uniprotkb:Q6DHZ9|uniprotkb:C0LSZ0 intact:EBI-2510245|ensembl:ENSP00000418751|ensembl:ENSP00000497066|uniprotkb:Q494V9|uniprotkb:Q96M00|uniprotkb:Q494W1 psi-mi:ubp25_human(display_long)|uniprotkb:USP25(gene name)|psi-mi:USP25(display_short)|uniprotkb:USP21(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 25(gene name synonym)|uniprotkb:Deubiquitinating enzyme 25(gene name synonym)|uniprotkb:USP on chromosome 21(gene name synonym)|uniprotkb:Ubiquitin thioesterase 25(gene name synonym) psi-mi:btbd9_human(display_long)|uniprotkb:BTBD9(gene name)|psi-mi:BTBD9(display_short)|uniprotkb:KIAA1880(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513469|imex:IM-12079-82 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000155313(gene)|ensembl:ENST00000285679(transcript)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006508"(proteolysis)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008233"(peptidase activity)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019783"(ubiquitin-like protein-specific protease activity)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032183"(SUMO binding)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:1904293"(negative regulation of ERAD pathway)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR009060(UBA-like)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|rcsb pdb:2MUX|rcsb pdb:5GP7|rcsb pdb:5O71|rcsb pdb:6H4J|rcsb pdb:6H4K|rcsb pdb:6HEL|rcsb pdb:6HEM|reactome:R-HSA-5689880|refseq:NP_001269970.1|refseq:NP_001269971.1|refseq:NP_037528.3 ensembl:ENSG00000183826(gene)|ensembl:ENST00000481247(transcript)|ensembl:ENST00000649492(transcript)|go:"GO:0007616"(long-term memory)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0042428"(serotonin metabolic process)|go:"GO:0042748"(circadian sleep/wake cycle, non-REM sleep)|go:"GO:0048512"(circadian behavior)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050951"(sensory perception of temperature stimulus)|go:"GO:0060586"(multicellular organismal iron ion homeostasis)|go:"GO:1900242"(regulation of synaptic vesicle endocytosis)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR000421(Coagulation factor 5/8 type, C-terminal)|interpro:IPR008979(Galactose-binding like)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR011705(BTB/Kelch-associated)|interpro:IPR034091|refseq:XP_011512581.1|refseq:NP_001092742.1|refseq:NP_001165889.1|refseq:NP_443125.1|refseq:NP_689946.2 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2020/03/02 rogid:PNngYJUduwx8fZiU1uDhAWYeZz49606 rogid:cjdtAwudivBKATkCJ5R/vYLhx4g9606 intact-crc:7484E4B2A570EFC8|rigid:WIzz4xOa88xf+gDErdD8fM1943o false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O94782 uniprotkb:P27482 intact:EBI-2513396|ensembl:ENSP00000343526|ensembl:ENSP00000360188|uniprotkb:Q9UNJ3|uniprotkb:A0PJ95|uniprotkb:Q9UFR0|uniprotkb:Q59H66|uniprotkb:Q05BX7|uniprotkb:D3DQ57 intact:EBI-747537|uniprotkb:Q5SQI4|uniprotkb:B2R9V6|ensembl:ENSP00000315299 psi-mi:ubp1_human(display_long)|uniprotkb:USP1(gene name)|psi-mi:USP1(display_short)|uniprotkb:Ubiquitin-specific-processing protease 1(gene name synonym)|uniprotkb:Deubiquitinating enzyme 1(gene name synonym)|uniprotkb:Ubiquitin thioesterase 1(gene name synonym) psi-mi:call3_human(display_long)|uniprotkb:Calmodulin-related protein NB-1(gene name synonym)|uniprotkb:CaM-like protein(gene name synonym)|uniprotkb:CALML3(gene name)|psi-mi:CALML3(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513405|imex:IM-12079-31 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000162607(gene)|ensembl:ENST00000339950(transcript)|ensembl:ENST00000371146(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008233"(peptidase activity)|go:"GO:0009411"(response to UV)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035520"(monoubiquitinated protein deubiquitination)|go:"GO:0042769"(obsolete DNA damage response, detection of DNA damage)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR033815|interpro:IPR038765|mint:O94782|rcsb pdb:6DO5|rcsb pdb:7AY0|rcsb pdb:7AY1|rcsb pdb:7AY2|reactome:R-HSA-110314|reactome:R-HSA-6783310|refseq:NP_001017415.1|refseq:NP_001017416.1|refseq:NP_003359.3|dip:DIP-53609N refseq:NP_005176.1|ensembl:ENSG00000178363(gene)|ensembl:ENST00000315238(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|mint:P27482|rcsb pdb:1GGZ psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2020/03/02 rogid:cSWX5JiI+vqbREjhCJeCGAiiVzE9606 rogid:7yRRBYvsbUxzIvnYaNmaIJ42i5Y9606 intact-crc:4EBAACE957B9BC40|rigid:6fDAfoC1Z0y+hER8/Gjb5vhvziQ false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O94782 uniprotkb:P19013 intact:EBI-2513396|ensembl:ENSP00000343526|ensembl:ENSP00000360188|uniprotkb:Q9UNJ3|uniprotkb:A0PJ95|uniprotkb:Q9UFR0|uniprotkb:Q59H66|uniprotkb:Q05BX7|uniprotkb:D3DQ57 intact:EBI-2371606|uniprotkb:Q6GTR8|uniprotkb:Q96LA7|uniprotkb:Q9BTL1|intact:EBI-22121113|uniprotkb:B4DRS2|uniprotkb:F8VS64|intact:EBI-22010019|intact:EBI-28973341|ensembl:ENSP00000448220 psi-mi:ubp1_human(display_long)|uniprotkb:USP1(gene name)|psi-mi:USP1(display_short)|uniprotkb:Ubiquitin-specific-processing protease 1(gene name synonym)|uniprotkb:Deubiquitinating enzyme 1(gene name synonym)|uniprotkb:Ubiquitin thioesterase 1(gene name synonym) psi-mi:k2c4_human(display_long)|uniprotkb:KRT4(gene name)|psi-mi:KRT4(display_short)|uniprotkb:CYK4(gene name synonym)|uniprotkb:Cytokeratin-4(gene name synonym)|uniprotkb:Keratin-4(gene name synonym)|uniprotkb:Type-II keratin Kb4(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513405|imex:IM-12079-31 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000162607(gene)|ensembl:ENST00000339950(transcript)|ensembl:ENST00000371146(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008233"(peptidase activity)|go:"GO:0009411"(response to UV)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035520"(monoubiquitinated protein deubiquitination)|go:"GO:0042769"(obsolete DNA damage response, detection of DNA damage)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR033815|interpro:IPR038765|mint:O94782|rcsb pdb:6DO5|rcsb pdb:7AY0|rcsb pdb:7AY1|rcsb pdb:7AY2|reactome:R-HSA-110314|reactome:R-HSA-6783310|refseq:NP_001017415.1|refseq:NP_001017416.1|refseq:NP_003359.3|dip:DIP-53609N ensembl:ENSP00000448220|refseq:NP_002263.3|ensembl:ENSG00000170477(gene)|ensembl:ENST00000551956(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005882"(intermediate filament)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0009986"(cell surface)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0045095"(keratin filament)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|interpro:IPR003054(Type II keratin)|interpro:IPR018039|interpro:IPR032444|interpro:IPR039008|mint:P19013|reactome:R-HSA-6805567|reactome:R-HSA-6809371 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2020/03/02 rogid:cSWX5JiI+vqbREjhCJeCGAiiVzE9606 rogid:WBLRjdlqvNYbC7R2ZSNON6QLcOU9606 intact-crc:4EBAACE957B9BC40|rigid:6fDAfoC1Z0y+hER8/Gjb5vhvziQ false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O94782 uniprotkb:P52294 intact:EBI-2513396|ensembl:ENSP00000343526|ensembl:ENSP00000360188|uniprotkb:Q9UNJ3|uniprotkb:A0PJ95|uniprotkb:Q9UFR0|uniprotkb:Q59H66|uniprotkb:Q05BX7|uniprotkb:D3DQ57 intact:EBI-358383|uniprotkb:Q9BQ56|uniprotkb:Q6IBQ9|intact:EBI-1058734|ensembl:ENSP00000343701|uniprotkb:D3DN93 psi-mi:ubp1_human(display_long)|uniprotkb:USP1(gene name)|psi-mi:USP1(display_short)|uniprotkb:Ubiquitin-specific-processing protease 1(gene name synonym)|uniprotkb:Deubiquitinating enzyme 1(gene name synonym)|uniprotkb:Ubiquitin thioesterase 1(gene name synonym) psi-mi:ima5_human(display_long)|uniprotkb:KPNA1(gene name)|psi-mi:KPNA1(display_short)|uniprotkb:RCH2(gene name synonym)|uniprotkb:Karyopherin subunit alpha-1(gene name synonym)|uniprotkb:SRP1-beta(gene name synonym)|uniprotkb:RAG cohort protein 2(gene name synonym)|uniprotkb:Nucleoprotein interactor 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513405|imex:IM-12079-31 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000162607(gene)|ensembl:ENST00000339950(transcript)|ensembl:ENST00000371146(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008233"(peptidase activity)|go:"GO:0009411"(response to UV)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035520"(monoubiquitinated protein deubiquitination)|go:"GO:0042769"(obsolete DNA damage response, detection of DNA damage)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR033815|interpro:IPR038765|mint:O94782|rcsb pdb:6DO5|rcsb pdb:7AY0|rcsb pdb:7AY1|rcsb pdb:7AY2|reactome:R-HSA-110314|reactome:R-HSA-6783310|refseq:NP_001017415.1|refseq:NP_001017416.1|refseq:NP_003359.3|dip:DIP-53609N refseq:NP_002255.3|ensembl:ENSG00000114030(gene)|ensembl:ENST00000344337(transcript)|go:"GO:0000018"(regulation of DNA recombination)|go:"GO:0005634"(nucleus)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006607"(NLS-bearing protein import into nucleus)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014841"(skeletal muscle satellite cell proliferation)|go:"GO:0014901"(satellite cell activation involved in skeletal muscle regeneration)|go:"GO:0030425"(dendrite)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0061608"(nuclear import signal receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|interpro:IPR000225(Armadillo)|interpro:IPR002652(Importin-alpha-like, importin-beta-binding region)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR024931|interpro:IPR032413|interpro:IPR036975|mint:P52294|rcsb pdb:2JDQ|rcsb pdb:3TJ3|rcsb pdb:4B18|rcsb pdb:6WX9|reactome:R-HSA-1169408|reactome:R-HSA-140342|reactome:R-HSA-162592|reactome:R-HSA-168271|reactome:R-HSA-168276|reactome:R-HSA-180910|reactome:R-HSA-909733|reactome:R-HSA-9636249|dip:DIP-29296N|refseq:XP_005247494.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2020/03/02 rogid:cSWX5JiI+vqbREjhCJeCGAiiVzE9606 rogid:eha8sOMYqe0OC6eXBA4eJLLsKFs9606 intact-crc:4EBAACE957B9BC40|rigid:6fDAfoC1Z0y+hER8/Gjb5vhvziQ false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O94782 uniprotkb:Q13107 intact:EBI-2513396|ensembl:ENSP00000343526|ensembl:ENSP00000360188|uniprotkb:Q9UNJ3|uniprotkb:A0PJ95|uniprotkb:Q9UFR0|uniprotkb:Q59H66|uniprotkb:Q05BX7|uniprotkb:D3DQ57 intact:EBI-723290|uniprotkb:O43452|uniprotkb:O43453|uniprotkb:Q08AK8|ensembl:ENSP00000265560|uniprotkb:A8K6Y0|uniprotkb:C9IY91 psi-mi:ubp1_human(display_long)|uniprotkb:USP1(gene name)|psi-mi:USP1(display_short)|uniprotkb:Ubiquitin-specific-processing protease 1(gene name synonym)|uniprotkb:Deubiquitinating enzyme 1(gene name synonym)|uniprotkb:Ubiquitin thioesterase 1(gene name synonym) psi-mi:ubp4_human(display_long)|uniprotkb:Ubiquitin-specific-processing protease 4(gene name synonym)|uniprotkb:Deubiquitinating enzyme 4(gene name synonym)|uniprotkb:Ubiquitous nuclear protein homolog(gene name synonym)|uniprotkb:USP4(gene name)|psi-mi:USP4(display_short)|uniprotkb:UNP(gene name synonym)|uniprotkb:UNPH(gene name synonym)|uniprotkb:Ubiquitin thioesterase 4(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513405|imex:IM-12079-31 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000162607(gene)|ensembl:ENST00000339950(transcript)|ensembl:ENST00000371146(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008233"(peptidase activity)|go:"GO:0009411"(response to UV)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035520"(monoubiquitinated protein deubiquitination)|go:"GO:0042769"(obsolete DNA damage response, detection of DNA damage)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR033815|interpro:IPR038765|mint:O94782|rcsb pdb:6DO5|rcsb pdb:7AY0|rcsb pdb:7AY1|rcsb pdb:7AY2|reactome:R-HSA-110314|reactome:R-HSA-6783310|refseq:NP_001017415.1|refseq:NP_001017416.1|refseq:NP_003359.3|dip:DIP-53609N refseq:NP_003354.2|refseq:NP_955475.1|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031685"(adenosine receptor binding)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR018200|interpro:IPR028135|interpro:IPR028889|interpro:IPR035927|interpro:IPR038765|mint:Q13107|rcsb pdb:2Y6E|rcsb pdb:5CTR|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5689880|ensembl:ENSG00000114316(gene)|ensembl:ENST00000265560(transcript)|go:"GO:0000244"(spliceosomal tri-snRNP complex assembly)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0031397"(negative regulation of protein ubiquitination)|refseq:NP_001238806.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2020/03/02 rogid:cSWX5JiI+vqbREjhCJeCGAiiVzE9606 rogid:uVbfLYa5ruPa6HBQehcQfXqI22w9606 intact-crc:4EBAACE957B9BC40|rigid:6fDAfoC1Z0y+hER8/Gjb5vhvziQ false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O94782 uniprotkb:Q02413 intact:EBI-2513396|ensembl:ENSP00000343526|ensembl:ENSP00000360188|uniprotkb:Q9UNJ3|uniprotkb:A0PJ95|uniprotkb:Q9UFR0|uniprotkb:Q59H66|uniprotkb:Q05BX7|uniprotkb:D3DQ57 intact:EBI-1045757|intact:EBI-28968615|ensembl:ENSP00000257192|uniprotkb:B7Z845 psi-mi:ubp1_human(display_long)|uniprotkb:USP1(gene name)|psi-mi:USP1(display_short)|uniprotkb:Ubiquitin-specific-processing protease 1(gene name synonym)|uniprotkb:Deubiquitinating enzyme 1(gene name synonym)|uniprotkb:Ubiquitin thioesterase 1(gene name synonym) psi-mi:dsg1_human(display_long)|uniprotkb:CDHF4(gene name synonym)|uniprotkb:Desmosomal glycoprotein 1(gene name synonym)|uniprotkb:Pemphigus foliaceus antigen(gene name synonym)|uniprotkb:DSG1(gene name)|psi-mi:DSG1(display_short)|uniprotkb:Cadherin family member 4(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513405|imex:IM-12079-31 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000162607(gene)|ensembl:ENST00000339950(transcript)|ensembl:ENST00000371146(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008233"(peptidase activity)|go:"GO:0009411"(response to UV)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035520"(monoubiquitinated protein deubiquitination)|go:"GO:0042769"(obsolete DNA damage response, detection of DNA damage)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR033815|interpro:IPR038765|mint:O94782|rcsb pdb:6DO5|rcsb pdb:7AY0|rcsb pdb:7AY1|rcsb pdb:7AY2|reactome:R-HSA-110314|reactome:R-HSA-6783310|refseq:NP_001017415.1|refseq:NP_001017416.1|refseq:NP_003359.3|dip:DIP-53609N ensembl:ENSP00000257192|refseq:NP_001933.2|ensembl:ENSG00000134760(gene)|ensembl:ENST00000257192(transcript)|go:"GO:0001533"(cornified envelope)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0015643"(toxic substance binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016339"(calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0030057"(desmosome)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0101003"(ficolin-1-rich granule membrane)|interpro:IPR000233(Cadherin cytoplasmic region)|interpro:IPR002126(Cadherin)|interpro:IPR009122(Desmosomal cadherin)|interpro:IPR009123(Desmoglein)|interpro:IPR015919(Cadherin-like)|interpro:IPR020894|interpro:IPR027397|mint:Q02413|reactome:R-HSA-351906|reactome:R-HSA-6798695|reactome:R-HSA-6805567|reactome:R-HSA-6809371|reactome:R-HSA-9696264|reactome:R-HSA-9696270 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2020/03/02 rogid:cSWX5JiI+vqbREjhCJeCGAiiVzE9606 rogid:CiRFIJ9IWOol9bQpLJPxH8JArtE9606 intact-crc:4EBAACE957B9BC40|rigid:6fDAfoC1Z0y+hER8/Gjb5vhvziQ false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O94782 uniprotkb:P20930 intact:EBI-2513396|ensembl:ENSP00000343526|ensembl:ENSP00000360188|uniprotkb:Q9UNJ3|uniprotkb:A0PJ95|uniprotkb:Q9UFR0|uniprotkb:Q59H66|uniprotkb:Q05BX7|uniprotkb:D3DQ57 intact:EBI-1058782|ensembl:ENSP00000357789|uniprotkb:Q01720|uniprotkb:Q5T583|uniprotkb:Q9UC71 psi-mi:ubp1_human(display_long)|uniprotkb:USP1(gene name)|psi-mi:USP1(display_short)|uniprotkb:Ubiquitin-specific-processing protease 1(gene name synonym)|uniprotkb:Deubiquitinating enzyme 1(gene name synonym)|uniprotkb:Ubiquitin thioesterase 1(gene name synonym) psi-mi:fila_human(display_long)|uniprotkb:FLG(gene name)|psi-mi:FLG(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513405|imex:IM-12079-31 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000162607(gene)|ensembl:ENST00000339950(transcript)|ensembl:ENST00000371146(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008233"(peptidase activity)|go:"GO:0009411"(response to UV)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035520"(monoubiquitinated protein deubiquitination)|go:"GO:0042769"(obsolete DNA damage response, detection of DNA damage)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR033815|interpro:IPR038765|mint:O94782|rcsb pdb:6DO5|rcsb pdb:7AY0|rcsb pdb:7AY1|rcsb pdb:7AY2|reactome:R-HSA-110314|reactome:R-HSA-6783310|refseq:NP_001017415.1|refseq:NP_001017416.1|refseq:NP_003359.3|dip:DIP-53609N ensembl:ENST00000368799(transcript)|go:"GO:0001533"(cornified envelope)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005882"(intermediate filament)|go:"GO:0007275"(multicellular organism development)|go:"GO:0018149"(peptide cross-linking)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030280"(structural constituent of skin epidermis)|go:"GO:0036457"(keratohyalin granule)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0046914"(transition metal ion binding)|go:"GO:0061436"(establishment of skin barrier)|ensembl:ENSG00000143631(gene)|interpro:IPR001751(S100/CaBP-9k-type, calcium binding)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR003303(Filaggrin)|interpro:IPR011992(EF-Hand type)|interpro:IPR013787(S100/CaBP-9k-type, calcium binding, subdomain)|interpro:IPR018247|interpro:IPR034325|rcsb pdb:4PCW|reactome:R-HSA-6809371|go:"GO:0062023"(collagen-containing extracellular matrix)|refseq:NP_002007.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2020/03/02 rogid:cSWX5JiI+vqbREjhCJeCGAiiVzE9606 rogid:RXgRbd4W6ydxD/M1cEUUzUFGuJ09606 intact-crc:4EBAACE957B9BC40|rigid:6fDAfoC1Z0y+hER8/Gjb5vhvziQ false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O94782 intact:EBI-2513393 intact:EBI-2513396|ensembl:ENSP00000343526|ensembl:ENSP00000360188|uniprotkb:Q9UNJ3|uniprotkb:A0PJ95|uniprotkb:Q9UFR0|uniprotkb:Q59H66|uniprotkb:Q05BX7|uniprotkb:D3DQ57 - psi-mi:ubp1_human(display_long)|uniprotkb:USP1(gene name)|psi-mi:USP1(display_short)|uniprotkb:Ubiquitin-specific-processing protease 1(gene name synonym)|uniprotkb:Deubiquitinating enzyme 1(gene name synonym)|uniprotkb:Ubiquitin thioesterase 1(gene name synonym) psi-mi:c9jh30_human(display_short)|psi-mi:EBI-2513393(display_long) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513405|imex:IM-12079-31 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000162607(gene)|ensembl:ENST00000339950(transcript)|ensembl:ENST00000371146(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008233"(peptidase activity)|go:"GO:0009411"(response to UV)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035520"(monoubiquitinated protein deubiquitination)|go:"GO:0042769"(obsolete DNA damage response, detection of DNA damage)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR033815|interpro:IPR038765|mint:O94782|rcsb pdb:6DO5|rcsb pdb:7AY0|rcsb pdb:7AY1|rcsb pdb:7AY2|reactome:R-HSA-110314|reactome:R-HSA-6783310|refseq:NP_001017415.1|refseq:NP_001017416.1|refseq:NP_003359.3|dip:DIP-53609N uniprotkb:C9JH30(uniprot-removed-ac) psi-mi:"MI:0469"(intact) - no-uniprot-update:|caution:The sequence has been withdrawn from uniprot. figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2020/03/02 rogid:cSWX5JiI+vqbREjhCJeCGAiiVzE9606 rogid:DwsRN8GfnwY2UXDBFDDXuLOd08A9606 intact-crc:4EBAACE957B9BC40|rigid:6fDAfoC1Z0y+hER8/Gjb5vhvziQ false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O94782 uniprotkb:P37802 intact:EBI-2513396|ensembl:ENSP00000343526|ensembl:ENSP00000360188|uniprotkb:Q9UNJ3|uniprotkb:A0PJ95|uniprotkb:Q9UFR0|uniprotkb:Q59H66|uniprotkb:Q05BX7|uniprotkb:D3DQ57 intact:EBI-1056740|intact:EBI-2825986|uniprotkb:Q5JRQ6|uniprotkb:Q5JRQ7|uniprotkb:Q9BUH5|uniprotkb:Q9H4P0|uniprotkb:Q6FGI1|uniprotkb:E9KL39|ensembl:ENSP00000357075|ensembl:ENSP00000357077 psi-mi:ubp1_human(display_long)|uniprotkb:USP1(gene name)|psi-mi:USP1(display_short)|uniprotkb:Ubiquitin-specific-processing protease 1(gene name synonym)|uniprotkb:Deubiquitinating enzyme 1(gene name synonym)|uniprotkb:Ubiquitin thioesterase 1(gene name synonym) psi-mi:tagl2_human(display_long)|uniprotkb:TAGLN2(gene name)|psi-mi:TAGLN2(display_short)|uniprotkb:KIAA0120(gene name synonym)|uniprotkb:SM22-alpha homolog(gene name synonym)|uniprotkb:CDABP0035(orf name)|uniprotkb:Epididymis tissue protein Li 7e(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513405|imex:IM-12079-31 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000162607(gene)|ensembl:ENST00000339950(transcript)|ensembl:ENST00000371146(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008233"(peptidase activity)|go:"GO:0009411"(response to UV)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035520"(monoubiquitinated protein deubiquitination)|go:"GO:0042769"(obsolete DNA damage response, detection of DNA damage)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR033815|interpro:IPR038765|mint:O94782|rcsb pdb:6DO5|rcsb pdb:7AY0|rcsb pdb:7AY1|rcsb pdb:7AY2|reactome:R-HSA-110314|reactome:R-HSA-6783310|refseq:NP_001017415.1|refseq:NP_001017416.1|refseq:NP_003359.3|dip:DIP-53609N refseq:NP_003555.1|refseq:NP_001264152.1|refseq:NP_001264153.1|ensembl:ENSG00000158710(gene)|ensembl:ENST00000320307(transcript)|ensembl:ENST00000368097(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0031982"(vesicle)|go:"GO:0045296"(cadherin binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000557(Calponin repeat)|interpro:IPR001061("Transgelin (SM22-alpha)")|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR003096(SM22/calponin)|interpro:IPR036872|mint:P37802|rcsb pdb:1WYM|reactome:R-HSA-114608 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2020/03/02 rogid:cSWX5JiI+vqbREjhCJeCGAiiVzE9606 rogid:JxbMK5SbZWQd+XA9iYc/xuNaVQc9606 intact-crc:4EBAACE957B9BC40|rigid:6fDAfoC1Z0y+hER8/Gjb5vhvziQ false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O94782 uniprotkb:P35579 intact:EBI-2513396|ensembl:ENSP00000343526|ensembl:ENSP00000360188|uniprotkb:Q9UNJ3|uniprotkb:A0PJ95|uniprotkb:Q9UFR0|uniprotkb:Q59H66|uniprotkb:Q05BX7|uniprotkb:D3DQ57 intact:EBI-350338|uniprotkb:O60805|ensembl:ENSP00000216181|uniprotkb:Q86T83|intact:EBI-1054343|uniprotkb:A8K6E4|uniprotkb:Q60FE2 psi-mi:ubp1_human(display_long)|uniprotkb:USP1(gene name)|psi-mi:USP1(display_short)|uniprotkb:Ubiquitin-specific-processing protease 1(gene name synonym)|uniprotkb:Deubiquitinating enzyme 1(gene name synonym)|uniprotkb:Ubiquitin thioesterase 1(gene name synonym) psi-mi:myh9_human(display_long)|uniprotkb:MYH9(gene name)|psi-mi:MYH9(display_short)|uniprotkb:Myosin heavy chain 9(gene name synonym)|uniprotkb:Myosin heavy chain, non-muscle IIa(gene name synonym)|uniprotkb:Non-muscle myosin heavy chain IIa(gene name synonym)|uniprotkb:Cellular myosin heavy chain, type A(gene name synonym)|uniprotkb:Non-muscle myosin heavy chain A(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513405|imex:IM-12079-31 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000162607(gene)|ensembl:ENST00000339950(transcript)|ensembl:ENST00000371146(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008233"(peptidase activity)|go:"GO:0009411"(response to UV)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035520"(monoubiquitinated protein deubiquitination)|go:"GO:0042769"(obsolete DNA damage response, detection of DNA damage)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR033815|interpro:IPR038765|mint:O94782|rcsb pdb:6DO5|rcsb pdb:7AY0|rcsb pdb:7AY1|rcsb pdb:7AY2|reactome:R-HSA-110314|reactome:R-HSA-6783310|refseq:NP_001017415.1|refseq:NP_001017416.1|refseq:NP_003359.3|dip:DIP-53609N refseq:NP_002464.1|ensembl:ENSG00000100345(gene)|ensembl:ENST00000216181(transcript)|go:"GO:0000146"(microfilament motor activity)|go:"GO:0000212"(meiotic spindle organization)|go:"GO:0001525"(angiogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001725"(stress fiber)|go:"GO:0001726"(ruffle)|go:"GO:0001768"(establishment of T cell polarity)|go:"GO:0001772"(immunological synapse)|go:"GO:0001778"(plasma membrane repair)|go:"GO:0001931"(uropod)|go:"GO:0003723"(RNA binding)|go:"GO:0003774"(cytoskeletal motor activity)|go:"GO:0003779"(actin binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005826"(actomyosin contractile ring)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007520"(myoblast fusion)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0015031"(protein transport)|refseq:XP_011528499.1|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016460"(myosin II complex)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0030220"(platelet formation)|go:"GO:0030224"(monocyte differentiation)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0031252"(cell leading edge)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032418"(lysosome localization)|go:"GO:0032506"(cytokinetic process)|go:"GO:0032796"(uropod organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0043531"(ADP binding)|go:"GO:0043534"(blood vessel endothelial cell migration)|go:"GO:0045055"(regulated exocytosis)|go:"GO:0045296"(cadherin binding)|go:"GO:0050900"(leukocyte migration)|go:"GO:0051015"(actin filament binding)|go:"GO:0051295"(establishment of meiotic spindle localization)|go:"GO:0060471"(cortical granule exocytosis)|go:"GO:0060473"(cortical granule)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:0097513"(myosin II filament)|go:"GO:1903919"(negative regulation of actin filament severing)|rcsb pdb:4CFR|rcsb pdb:4ETO|reactome:R-HSA-1445148|reactome:R-HSA-2029482|reactome:R-HSA-3928663|reactome:R-HSA-416572|reactome:R-HSA-5625740|reactome:R-HSA-5625900|reactome:R-HSA-5627117|reactome:R-HSA-5627123|reactome:R-HSA-9662360|reactome:R-HSA-9662361|reactome:R-HSA-9662834|reactome:R-HSA-9664422|go:"GO:1903923"(positive regulation of protein processing in phagocytic vesicle)|go:"GO:1905684"(regulation of plasma membrane repair)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR001609(Myosin head, motor region)|interpro:IPR002928(Myosin tail)|interpro:IPR004009(Myosin, N-terminal, SH3-like)|interpro:IPR008989(Myosin S1 fragment, N-terminal)|interpro:IPR027417|interpro:IPR036305|interpro:IPR036961|mint:P35579|rcsb pdb:2LNK|rcsb pdb:3ZWH|rcsb pdb:4CFQ|refseq:XP_016884292.1|refseq:XP_016884293.1|refseq:XP_016884294.1|refseq:XP_016884295.1|dip:DIP-33103N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2020/03/02 rogid:cSWX5JiI+vqbREjhCJeCGAiiVzE9606 rogid:fSOtpFpr8PSnAG5UdAr/khwkzJs9606 intact-crc:4EBAACE957B9BC40|rigid:6fDAfoC1Z0y+hER8/Gjb5vhvziQ false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O94782 uniprotkb:Q04695 intact:EBI-2513396|ensembl:ENSP00000343526|ensembl:ENSP00000360188|uniprotkb:Q9UNJ3|uniprotkb:A0PJ95|uniprotkb:Q9UFR0|uniprotkb:Q59H66|uniprotkb:Q05BX7|uniprotkb:D3DQ57 intact:EBI-297873|ensembl:ENSP00000308452|uniprotkb:A5Z1M9|uniprotkb:A5Z1N0|uniprotkb:A5Z1N1|uniprotkb:A5Z1N2|uniprotkb:A6NDV6|uniprotkb:A6NKQ2|uniprotkb:Q6IP98|uniprotkb:Q8N1P6 psi-mi:ubp1_human(display_long)|uniprotkb:USP1(gene name)|psi-mi:USP1(display_short)|uniprotkb:Ubiquitin-specific-processing protease 1(gene name synonym)|uniprotkb:Deubiquitinating enzyme 1(gene name synonym)|uniprotkb:Ubiquitin thioesterase 1(gene name synonym) psi-mi:k1c17_human(display_long)|uniprotkb:KRT17(gene name)|psi-mi:KRT17(display_short)|uniprotkb:Cytokeratin-17(gene name synonym)|uniprotkb:39.1(gene name synonym)|uniprotkb:Keratin-17(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513405|imex:IM-12079-31 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000162607(gene)|ensembl:ENST00000339950(transcript)|ensembl:ENST00000371146(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008233"(peptidase activity)|go:"GO:0009411"(response to UV)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035520"(monoubiquitinated protein deubiquitination)|go:"GO:0042769"(obsolete DNA damage response, detection of DNA damage)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR033815|interpro:IPR038765|mint:O94782|rcsb pdb:6DO5|rcsb pdb:7AY0|rcsb pdb:7AY1|rcsb pdb:7AY2|reactome:R-HSA-110314|reactome:R-HSA-6783310|refseq:NP_001017415.1|refseq:NP_001017416.1|refseq:NP_003359.3|dip:DIP-53609N ensembl:ENSG00000128422(gene)|ensembl:ENST00000311208(transcript)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005829"(cytosol)|go:"GO:0005882"(intermediate filament)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0031424"(keratinization)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0051798"(positive regulation of hair follicle development)|go:"GO:0071944"(cell periphery)|interpro:IPR002957(Keratin, type I)|interpro:IPR018039|interpro:IPR039008|mint:Q04695|reactome:R-HSA-6805567|reactome:R-HSA-6809371|refseq:NP_000413.1|dip:DIP-33093N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2020/03/02 rogid:cSWX5JiI+vqbREjhCJeCGAiiVzE9606 rogid:cwKlvMqhQGUokThbIxgEkB6Wzxw9606 intact-crc:4EBAACE957B9BC40|rigid:6fDAfoC1Z0y+hER8/Gjb5vhvziQ false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O94782 uniprotkb:Q13835 intact:EBI-2513396|ensembl:ENSP00000343526|ensembl:ENSP00000360188|uniprotkb:Q9UNJ3|uniprotkb:A0PJ95|uniprotkb:Q9UFR0|uniprotkb:Q59H66|uniprotkb:Q05BX7|uniprotkb:D3DQ57 intact:EBI-2513407|ensembl:ENSP00000263946|ensembl:ENSP00000295597|uniprotkb:O00645|uniprotkb:Q14CA0|uniprotkb:Q15152 psi-mi:ubp1_human(display_long)|uniprotkb:USP1(gene name)|psi-mi:USP1(display_short)|uniprotkb:Ubiquitin-specific-processing protease 1(gene name synonym)|uniprotkb:Deubiquitinating enzyme 1(gene name synonym)|uniprotkb:Ubiquitin thioesterase 1(gene name synonym) psi-mi:pkp1_human(display_long)|uniprotkb:PKP1(gene name)|psi-mi:PKP1(display_short)|uniprotkb:Band 6 protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513405|imex:IM-12079-31 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000162607(gene)|ensembl:ENST00000339950(transcript)|ensembl:ENST00000371146(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008233"(peptidase activity)|go:"GO:0009411"(response to UV)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035520"(monoubiquitinated protein deubiquitination)|go:"GO:0042769"(obsolete DNA damage response, detection of DNA damage)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR033815|interpro:IPR038765|mint:O94782|rcsb pdb:6DO5|rcsb pdb:7AY0|rcsb pdb:7AY1|rcsb pdb:7AY2|reactome:R-HSA-110314|reactome:R-HSA-6783310|refseq:NP_001017415.1|refseq:NP_001017416.1|refseq:NP_003359.3|dip:DIP-53609N go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0005912"(adherens junction)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019215"(intermediate filament binding)|go:"GO:0030057"(desmosome)|go:"GO:0030280"(structural constituent of skin epidermis)|go:"GO:0045110"(intermediate filament bundle assembly)|go:"GO:0045296"(cadherin binding)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0101003"(ficolin-1-rich granule membrane)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1990124"(messenger ribonucleoprotein complex)|interpro:IPR000225(Armadillo)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR028432|interpro:IPR028435|mint:Q13835|reactome:R-HSA-351906|reactome:R-HSA-6798695|reactome:R-HSA-6805567|reactome:R-HSA-6809371|rcsb pdb:1XM9|ensembl:ENSG00000081277(gene)|ensembl:ENST00000263946(transcript)|ensembl:ENST00000352845(transcript)|go:"GO:0001533"(cornified envelope)|go:"GO:0005521"(lamin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005882"(intermediate filament)|go:"GO:0005886"(plasma membrane)|refseq:NP_000290.2|refseq:NP_001005337.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2020/03/02 rogid:cSWX5JiI+vqbREjhCJeCGAiiVzE9606 rogid:j2bzqEmWBUDLVnjl2JX/i4nI8P49606 intact-crc:4EBAACE957B9BC40|rigid:6fDAfoC1Z0y+hER8/Gjb5vhvziQ false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O94782 uniprotkb:O60346 intact:EBI-2513396|ensembl:ENSP00000343526|ensembl:ENSP00000360188|uniprotkb:Q9UNJ3|uniprotkb:A0PJ95|uniprotkb:Q9UFR0|uniprotkb:Q59H66|uniprotkb:Q05BX7|uniprotkb:D3DQ57 intact:EBI-2511516|intact:EBI-28974360|ensembl:ENSP00000262719|uniprotkb:Q6PJI6|uniprotkb:Q6P4C4|uniprotkb:A1A4F5|uniprotkb:Q641Q7|uniprotkb:Q86TN6|uniprotkb:Q96FK2|uniprotkb:Q9NUY1 psi-mi:ubp1_human(display_long)|uniprotkb:USP1(gene name)|psi-mi:USP1(display_short)|uniprotkb:Ubiquitin-specific-processing protease 1(gene name synonym)|uniprotkb:Deubiquitinating enzyme 1(gene name synonym)|uniprotkb:Ubiquitin thioesterase 1(gene name synonym) psi-mi:phlp1_human(display_long)|uniprotkb:PHLPP1(gene name)|psi-mi:PHLPP1(display_short)|uniprotkb:KIAA0606(gene name synonym)|uniprotkb:PHLPP(gene name synonym)|uniprotkb:PLEKHE1(gene name synonym)|uniprotkb:SCOP(gene name synonym)|uniprotkb:Pleckstrin homology domain-containing family E member 1(gene name synonym)|uniprotkb:Suprachiasmatic nucleus circadian oscillatory protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513405|imex:IM-12079-31 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000162607(gene)|ensembl:ENST00000339950(transcript)|ensembl:ENST00000371146(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008233"(peptidase activity)|go:"GO:0009411"(response to UV)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035520"(monoubiquitinated protein deubiquitination)|go:"GO:0042769"(obsolete DNA damage response, detection of DNA damage)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR033815|interpro:IPR038765|mint:O94782|rcsb pdb:6DO5|rcsb pdb:7AY0|rcsb pdb:7AY1|rcsb pdb:7AY2|reactome:R-HSA-110314|reactome:R-HSA-6783310|refseq:NP_001017415.1|refseq:NP_001017416.1|refseq:NP_003359.3|dip:DIP-53609N ensembl:ENSP00000262719|go:"GO:0009649"(entrainment of circadian clock)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046872"(metal ion binding)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1900744"(regulation of p38MAPK cascade)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001932(Protein phosphatase 2C-related)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR032675|interpro:IPR036457|mint:O60346|reactome:R-HSA-199418|ensembl:ENSG00000081913(gene)|ensembl:ENST00000262719(transcript)|go:"GO:0002667"(regulation of T cell anergy)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|refseq:NP_919431.2 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2020/03/02 rogid:cSWX5JiI+vqbREjhCJeCGAiiVzE9606 rogid:hPGjeSVMlJhO3o9YBWoBm9xppfk9606 intact-crc:4EBAACE957B9BC40|rigid:6fDAfoC1Z0y+hER8/Gjb5vhvziQ false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O94782 uniprotkb:P47929 intact:EBI-2513396|ensembl:ENSP00000343526|ensembl:ENSP00000360188|uniprotkb:Q9UNJ3|uniprotkb:A0PJ95|uniprotkb:Q9UFR0|uniprotkb:Q59H66|uniprotkb:Q05BX7|uniprotkb:D3DQ57 intact:EBI-357504|ensembl:ENSP00000313571|ensembl:ENSP00000367891|ensembl:ENSP00000489395|ensembl:ENSP00000489582|uniprotkb:Q6IB87 psi-mi:ubp1_human(display_long)|uniprotkb:USP1(gene name)|psi-mi:USP1(display_short)|uniprotkb:Ubiquitin-specific-processing protease 1(gene name synonym)|uniprotkb:Deubiquitinating enzyme 1(gene name synonym)|uniprotkb:Ubiquitin thioesterase 1(gene name synonym) psi-mi:leg7_human(display_long)|uniprotkb:LGALS7(gene name)|psi-mi:LGALS7(display_short)|uniprotkb:PIG1(gene name synonym)|uniprotkb:HKL-14(gene name synonym)|uniprotkb:PI7(gene name synonym)|uniprotkb:p53-induced gene 1 protein(gene name synonym)|uniprotkb:LGALS7B(gene name)|psi-mi:LGALS7B(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513405|imex:IM-12079-31 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000162607(gene)|ensembl:ENST00000339950(transcript)|ensembl:ENST00000371146(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008233"(peptidase activity)|go:"GO:0009411"(response to UV)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035520"(monoubiquitinated protein deubiquitination)|go:"GO:0042769"(obsolete DNA damage response, detection of DNA damage)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR033815|interpro:IPR038765|mint:O94782|rcsb pdb:6DO5|rcsb pdb:7AY0|rcsb pdb:7AY1|rcsb pdb:7AY2|reactome:R-HSA-110314|reactome:R-HSA-6783310|refseq:NP_001017415.1|refseq:NP_001017416.1|refseq:NP_003359.3|dip:DIP-53609N ensembl:ENSG00000178934(gene)|ensembl:ENSG00000205076(gene)|ensembl:ENSG00000282902(gene)|ensembl:ENSG00000283082(gene)|ensembl:ENST00000314980(transcript)|ensembl:ENST00000378626(transcript)|ensembl:ENST00000634448(transcript)|ensembl:ENST00000634800(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016936"(galactoside binding)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0070062"(extracellular exosome)|go:"GO:2000562"(negative regulation of CD4-positive, alpha-beta T cell proliferation)|interpro:IPR001079(Galectin, galactose-binding lectin)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR030640|interpro:IPR044156|mint:P47929|rcsb pdb:1BKZ|rcsb pdb:2GAL|rcsb pdb:3GAL|rcsb pdb:3ZXE|rcsb pdb:3ZXF|rcsb pdb:4GAL|rcsb pdb:4UW3|rcsb pdb:4UW4|rcsb pdb:4UW5|rcsb pdb:4UW6|rcsb pdb:4XBQ|rcsb pdb:4Y26|rcsb pdb:5GAL|rcsb pdb:5H9Q|rcsb pdb:5H9S|refseq:NP_001035972.1|refseq:NP_002298.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2020/03/02 rogid:cSWX5JiI+vqbREjhCJeCGAiiVzE9606 rogid:TIAlvVZ7rOYqTAGrYAFbJY231gc9606 intact-crc:4EBAACE957B9BC40|rigid:6fDAfoC1Z0y+hER8/Gjb5vhvziQ false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O94782 uniprotkb:Q8TAF3 intact:EBI-2513396|ensembl:ENSP00000343526|ensembl:ENSP00000360188|uniprotkb:Q9UNJ3|uniprotkb:A0PJ95|uniprotkb:Q9UFR0|uniprotkb:Q59H66|uniprotkb:Q05BX7|uniprotkb:D3DQ57 intact:EBI-1045469|uniprotkb:Q63HJ2|uniprotkb:Q658Y1|uniprotkb:Q8N3Z1|uniprotkb:Q9NSK8|uniprotkb:Q9P279|uniprotkb:B4DM86|uniprotkb:B4DQI2|uniprotkb:B4DY84|ensembl:ENSP00000307491 psi-mi:ubp1_human(display_long)|uniprotkb:USP1(gene name)|psi-mi:USP1(display_short)|uniprotkb:Ubiquitin-specific-processing protease 1(gene name synonym)|uniprotkb:Deubiquitinating enzyme 1(gene name synonym)|uniprotkb:Ubiquitin thioesterase 1(gene name synonym) psi-mi:wdr48_human(display_long)|uniprotkb:WD repeat endosomal protein(gene name synonym)|uniprotkb:p80(gene name synonym)|uniprotkb:WDR48(gene name)|psi-mi:WDR48(display_short)|uniprotkb:KIAA1449(gene name synonym)|uniprotkb:UAF1(gene name synonym)|uniprotkb:USP1-associated factor 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513405|imex:IM-12079-31 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000162607(gene)|ensembl:ENST00000339950(transcript)|ensembl:ENST00000371146(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008233"(peptidase activity)|go:"GO:0009411"(response to UV)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035520"(monoubiquitinated protein deubiquitination)|go:"GO:0042769"(obsolete DNA damage response, detection of DNA damage)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR033815|interpro:IPR038765|mint:O94782|rcsb pdb:6DO5|rcsb pdb:7AY0|rcsb pdb:7AY1|rcsb pdb:7AY2|reactome:R-HSA-110314|reactome:R-HSA-6783310|refseq:NP_001017415.1|refseq:NP_001017416.1|refseq:NP_003359.3|dip:DIP-53609N refseq:NP_065890.1|ensembl:ENSG00000114742(gene)|ensembl:ENST00000302313(transcript)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0003677"(DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043588"(skin development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0072520"(seminiferous tubule development)|go:"GO:1902525"(regulation of protein monoubiquitination)|go:"GO:1903003"(positive regulation of protein deubiquitination)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR021772|interpro:IPR036322|mint:Q8TAF3|rcsb pdb:5CVL|rcsb pdb:5CVN|rcsb pdb:5CVO|rcsb pdb:5K1A|rcsb pdb:5K1B|rcsb pdb:5K1C|rcsb pdb:5L8E|rcsb pdb:5L8W|rcsb pdb:6JLQ|rcsb pdb:7AY0|rcsb pdb:7AY1|rcsb pdb:7AY2|reactome:R-HSA-110314|reactome:R-HSA-5689880|reactome:R-HSA-6783310|reactome:R-HSA-9673766|refseq:NP_001290331.1|refseq:NP_001290332.1|refseq:NP_001333156.1|refseq:NP_001333157.1|dip:DIP-50841N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2020/03/02 rogid:cSWX5JiI+vqbREjhCJeCGAiiVzE9606 rogid:S8ihl3jxEEyMS46AM2ynXSFfCU49606 intact-crc:4EBAACE957B9BC40|rigid:6fDAfoC1Z0y+hER8/Gjb5vhvziQ false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O94782 uniprotkb:P61626 intact:EBI-2513396|ensembl:ENSP00000343526|ensembl:ENSP00000360188|uniprotkb:Q9UNJ3|uniprotkb:A0PJ95|uniprotkb:Q9UFR0|uniprotkb:Q59H66|uniprotkb:Q05BX7|uniprotkb:D3DQ57 intact:EBI-355360|ensembl:ENSP00000261267|uniprotkb:P00695|uniprotkb:Q9UCF8|uniprotkb:Q13170 psi-mi:ubp1_human(display_long)|uniprotkb:USP1(gene name)|psi-mi:USP1(display_short)|uniprotkb:Ubiquitin-specific-processing protease 1(gene name synonym)|uniprotkb:Deubiquitinating enzyme 1(gene name synonym)|uniprotkb:Ubiquitin thioesterase 1(gene name synonym) psi-mi:lysc_human(display_long)|uniprotkb:LYZ(gene name)|psi-mi:LYZ(display_short)|uniprotkb:LZM(gene name synonym)|uniprotkb:1,4-beta-N-acetylmuramidase C(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513405|imex:IM-12079-31 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000162607(gene)|ensembl:ENST00000339950(transcript)|ensembl:ENST00000371146(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008233"(peptidase activity)|go:"GO:0009411"(response to UV)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035520"(monoubiquitinated protein deubiquitination)|go:"GO:0042769"(obsolete DNA damage response, detection of DNA damage)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR033815|interpro:IPR038765|mint:O94782|rcsb pdb:6DO5|rcsb pdb:7AY0|rcsb pdb:7AY1|rcsb pdb:7AY2|reactome:R-HSA-110314|reactome:R-HSA-6783310|refseq:NP_001017415.1|refseq:NP_001017416.1|refseq:NP_003359.3|dip:DIP-53609N ensembl:ENSG00000090382(gene)|refseq:NP_000230.1|rcsb pdb:1GB7|rcsb pdb:1GB8|rcsb pdb:1GB9|rcsb pdb:1GBO|rcsb pdb:1GBW|rcsb pdb:1GBX|rcsb pdb:1GBY|rcsb pdb:1GBZ|rcsb pdb:1GDW|rcsb pdb:1GDX|rcsb pdb:1GE0|rcsb pdb:1GE1|rcsb pdb:1GE2|rcsb pdb:1GE3|rcsb pdb:1GE4|rcsb pdb:1GEV|rcsb pdb:1GEZ|rcsb pdb:1GF0|rcsb pdb:1GF3|rcsb pdb:1GF4|rcsb pdb:1GF5|rcsb pdb:1GF6|rcsb pdb:1GF7|rcsb pdb:1GF8|rcsb pdb:1GF9|rcsb pdb:1GFA|rcsb pdb:1GFE|rcsb pdb:1GFG|rcsb pdb:1GFH|rcsb pdb:1GFJ|rcsb pdb:1GFK|rcsb pdb:1GFR|rcsb pdb:1GFT|rcsb pdb:1GFU|rcsb pdb:1GFV|rcsb pdb:1HNL|rcsb pdb:1I1Z|rcsb pdb:1I20|rcsb pdb:1I22|rcsb pdb:1INU|rcsb pdb:1IOC|rcsb pdb:1IP1|rcsb pdb:1IP2|rcsb pdb:1IP3|rcsb pdb:1IP4|rcsb pdb:1IP5|rcsb pdb:1IP6|rcsb pdb:1IP7|rcsb pdb:1IWT|rcsb pdb:1IWU|rcsb pdb:1IWV|rcsb pdb:1IWW|rcsb pdb:1IWX|rcsb pdb:1IWY|rcsb pdb:1IWZ|rcsb pdb:1IX0|rcsb pdb:1IY3|rcsb pdb:1IY4|rcsb pdb:1JKA|rcsb pdb:1JKB|rcsb pdb:1JKC|rcsb pdb:1JKD|rcsb pdb:1JSF|rcsb pdb:1JWR|rcsb pdb:1LAA|rcsb pdb:1LHH|rcsb pdb:1LHI|rcsb pdb:1LHJ|rcsb pdb:1LHK|rcsb pdb:1LHL|rcsb pdb:1LHM|rcsb pdb:1LMT|rcsb pdb:1LOZ|rcsb pdb:1LYY|rcsb pdb:1LZ1|rcsb pdb:1LZ4|rcsb pdb:1LZ5|rcsb pdb:1LZ6|rcsb pdb:1LZR|rcsb pdb:1LZS|rcsb pdb:1OP9|rcsb pdb:1OUA|rcsb pdb:1OUB|rcsb pdb:1OUC|rcsb pdb:1OUD|rcsb pdb:1OUE|rcsb pdb:1OUF|rcsb pdb:1OUG|rcsb pdb:1OUH|rcsb pdb:1OUI|rcsb pdb:1OUJ|rcsb pdb:1QSW|rcsb pdb:1RE2|rcsb pdb:1REM|rcsb pdb:1REX|rcsb pdb:1REY|rcsb pdb:1REZ|rcsb pdb:1TAY|rcsb pdb:1TBY|rcsb pdb:1TCY|rcsb pdb:1TDY|rcsb pdb:1UBZ|rcsb pdb:5LVK|rcsb pdb:6LFH|reactome:R-HSA-6798695|reactome:R-HSA-6803157|reactome:R-HSA-977225|rcsb pdb:1W08|rcsb pdb:1WQM|rcsb pdb:1WQN|rcsb pdb:1WQO|rcsb pdb:1WQP|rcsb pdb:1WQQ|rcsb pdb:1WQR|rcsb pdb:1YAM|rcsb pdb:1YAN|rcsb pdb:1YAO|rcsb pdb:1YAP|rcsb pdb:1YAQ|rcsb pdb:207L|rcsb pdb:208L|rcsb pdb:2BQA|rcsb pdb:2BQB|rcsb pdb:2BQC|rcsb pdb:2BQD|rcsb pdb:2BQE|rcsb pdb:2BQF|rcsb pdb:2BQG|rcsb pdb:2BQH|rcsb pdb:2BQI|rcsb pdb:2BQJ|rcsb pdb:2BQK|rcsb pdb:2BQL|rcsb pdb:2BQM|rcsb pdb:2BQN|rcsb pdb:2BQO|rcsb pdb:2HEA|rcsb pdb:2HEB|rcsb pdb:2HEC|rcsb pdb:2HED|rcsb pdb:2HEE|rcsb pdb:2HEF|rcsb pdb:2LHM|rcsb pdb:2MEA|rcsb pdb:2MEB|rcsb pdb:2MEC|rcsb pdb:2MED|rcsb pdb:2MEE|rcsb pdb:2MEF|rcsb pdb:2MEG|rcsb pdb:2MEH|rcsb pdb:2MEI|rcsb pdb:2NWD|rcsb pdb:2ZIJ|rcsb pdb:2ZIK|rcsb pdb:2ZIL|rcsb pdb:2ZWB|rcsb pdb:3EBA|rcsb pdb:3FE0|rcsb pdb:3LHM|rcsb pdb:3LN2|rcsb pdb:4I0C|rcsb pdb:4ML7|rcsb pdb:4R0P|rcsb pdb:5LSH|rcsb pdb:1B5X|rcsb pdb:1B5Y|rcsb pdb:1B5Z|rcsb pdb:1B7L|rcsb pdb:1B7M|rcsb pdb:1B7N|rcsb pdb:1B7O|rcsb pdb:1B7P|rcsb pdb:1B7Q|rcsb pdb:1B7R|rcsb pdb:1B7S|rcsb pdb:1BB3|rcsb pdb:1BB4|rcsb pdb:1BB5|rcsb pdb:1C43|rcsb pdb:1C45|rcsb pdb:1C46|rcsb pdb:1C7P|rcsb pdb:1CJ6|rcsb pdb:1CJ7|rcsb pdb:1CJ8|ensembl:ENST00000261267(transcript)|go:"GO:0001895"(retina homeostasis)|go:"GO:0003796"(lysozyme activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006954"(inflammatory response)|go:"GO:0008152"(metabolic process)|go:"GO:0019730"(antimicrobial humoral response)|go:"GO:0019835"(cytolysis)|go:"GO:0031640"(killing of cells of another organism)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0035580"(specific granule lumen)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904724"(tertiary granule lumen)|interpro:IPR000974(Glycoside hydrolase, family 22, lysozyme)|interpro:IPR001916(Glycoside hydrolase, family 22)|interpro:IPR019799|interpro:IPR023346|interpro:IPR030056|mint:P61626|rcsb pdb:133L|rcsb pdb:134L|rcsb pdb:1B5U|rcsb pdb:1B5V|rcsb pdb:1B5W|rcsb pdb:1CJ9|rcsb pdb:1CKC|rcsb pdb:1CKD|rcsb pdb:1CKF|rcsb pdb:1CKG|rcsb pdb:1CKH|rcsb pdb:1D6P|rcsb pdb:1D6Q|rcsb pdb:1DI3|rcsb pdb:1DI4|rcsb pdb:1DI5|rcsb pdb:1EQ4|rcsb pdb:1EQ5|rcsb pdb:1EQE|rcsb pdb:1GAY|rcsb pdb:1GAZ|rcsb pdb:1GB0|rcsb pdb:1GB2|rcsb pdb:1GB3|rcsb pdb:1GB5|rcsb pdb:1GB6 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2020/03/02 rogid:cSWX5JiI+vqbREjhCJeCGAiiVzE9606 rogid:jydNN9yuU9EYvnth+kv115svRxw9606 intact-crc:4EBAACE957B9BC40|rigid:6fDAfoC1Z0y+hER8/Gjb5vhvziQ false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O94782 uniprotkb:P04792 intact:EBI-2513396|ensembl:ENSP00000343526|ensembl:ENSP00000360188|uniprotkb:Q9UNJ3|uniprotkb:A0PJ95|uniprotkb:Q9UFR0|uniprotkb:Q59H66|uniprotkb:Q05BX7|uniprotkb:D3DQ57 intact:EBI-352682|uniprotkb:Q6FI47|uniprotkb:Q96C20|uniprotkb:Q96EI7|uniprotkb:Q9UC34|uniprotkb:Q9UC35|uniprotkb:Q9UC36|uniprotkb:Q9UC31|ensembl:ENSP00000248553|uniprotkb:B2R4N8 psi-mi:ubp1_human(display_long)|uniprotkb:USP1(gene name)|psi-mi:USP1(display_short)|uniprotkb:Ubiquitin-specific-processing protease 1(gene name synonym)|uniprotkb:Deubiquitinating enzyme 1(gene name synonym)|uniprotkb:Ubiquitin thioesterase 1(gene name synonym) psi-mi:hspb1_human(display_long)|uniprotkb:HSPB1(gene name)|psi-mi:HSPB1(display_short)|uniprotkb:HSP27(gene name synonym)|uniprotkb:HSP28(gene name synonym)|uniprotkb:Heat shock 27 kDa protein(gene name synonym)|uniprotkb:Stress-responsive protein 27(gene name synonym)|uniprotkb:Estrogen-regulated 24 kDa protein(gene name synonym)|uniprotkb:28 kDa heat shock protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513405|imex:IM-12079-31 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000162607(gene)|ensembl:ENST00000339950(transcript)|ensembl:ENST00000371146(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008233"(peptidase activity)|go:"GO:0009411"(response to UV)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035520"(monoubiquitinated protein deubiquitination)|go:"GO:0042769"(obsolete DNA damage response, detection of DNA damage)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR033815|interpro:IPR038765|mint:O94782|rcsb pdb:6DO5|rcsb pdb:7AY0|rcsb pdb:7AY1|rcsb pdb:7AY2|reactome:R-HSA-110314|reactome:R-HSA-6783310|refseq:NP_001017415.1|refseq:NP_001017416.1|refseq:NP_003359.3|dip:DIP-53609N refseq:NP_001531.1|ensembl:ENSG00000106211(gene)|ensembl:ENST00000248553(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0001895"(retina homeostasis)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0008426"(protein kinase C inhibitor activity)|go:"GO:0009615"(response to virus)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0038033"(positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:0099641"(anterograde axonal protein transport)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1904115"(axon cytoplasm)|go:"GO:2001028"(positive regulation of endothelial cell chemotaxis)|interpro:IPR001436(Alpha crystallin/Heat shock protein)|interpro:IPR002068(Heat shock protein Hsp20)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR037876|mint:P04792|rcsb pdb:2N3J|rcsb pdb:3Q9P|rcsb pdb:3Q9Q|rcsb pdb:4MJH|rcsb pdb:6DV5|rcsb pdb:6GJH|reactome:R-HSA-4420097|reactome:R-HSA-450408|reactome:R-HSA-5687128|reactome:R-HSA-9009391|dip:DIP-412N psi-mi:"MI:0469"(intact) - crc64:1B4DC44A6F6606D5 figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2020/03/02 rogid:cSWX5JiI+vqbREjhCJeCGAiiVzE9606 rogid:vrDXIdzP30aHSDLHOh2D4x54eJY9606 intact-crc:4EBAACE957B9BC40|rigid:6fDAfoC1Z0y+hER8/Gjb5vhvziQ false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O94782 uniprotkb:Q9NZT1 intact:EBI-2513396|ensembl:ENSP00000343526|ensembl:ENSP00000360188|uniprotkb:Q9UNJ3|uniprotkb:A0PJ95|uniprotkb:Q9UFR0|uniprotkb:Q59H66|uniprotkb:Q05BX7|uniprotkb:D3DQ57 intact:EBI-1051681|uniprotkb:Q8IXU8|uniprotkb:Q5SQI3|ensembl:ENSP00000369689 psi-mi:ubp1_human(display_long)|uniprotkb:USP1(gene name)|psi-mi:USP1(display_short)|uniprotkb:Ubiquitin-specific-processing protease 1(gene name synonym)|uniprotkb:Deubiquitinating enzyme 1(gene name synonym)|uniprotkb:Ubiquitin thioesterase 1(gene name synonym) psi-mi:call5_human(display_long)|uniprotkb:Calmodulin-like skin protein(gene name synonym)|uniprotkb:CALML5(gene name)|psi-mi:CALML5(display_short)|uniprotkb:CLSP(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513405|imex:IM-12079-31 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000162607(gene)|ensembl:ENST00000339950(transcript)|ensembl:ENST00000371146(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008233"(peptidase activity)|go:"GO:0009411"(response to UV)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035520"(monoubiquitinated protein deubiquitination)|go:"GO:0042769"(obsolete DNA damage response, detection of DNA damage)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR033815|interpro:IPR038765|mint:O94782|rcsb pdb:6DO5|rcsb pdb:7AY0|rcsb pdb:7AY1|rcsb pdb:7AY2|reactome:R-HSA-110314|reactome:R-HSA-6783310|refseq:NP_001017415.1|refseq:NP_001017416.1|refseq:NP_003359.3|dip:DIP-53609N refseq:NP_059118.2|ensembl:ENST00000380332(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0007165"(signal transduction)|go:"GO:0008544"(epidermis development)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|mint:Q9NZT1|rcsb pdb:2B1U|reactome:R-HSA-6798695|ensembl:ENSG00000178372(gene) psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2020/03/02 rogid:cSWX5JiI+vqbREjhCJeCGAiiVzE9606 rogid:uPD/avsoqpiogqHCK5TGJQwvCX89606 intact-crc:4EBAACE957B9BC40|rigid:6fDAfoC1Z0y+hER8/Gjb5vhvziQ false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O94782 uniprotkb:Q8IZ83 intact:EBI-2513396|ensembl:ENSP00000343526|ensembl:ENSP00000360188|uniprotkb:Q9UNJ3|uniprotkb:A0PJ95|uniprotkb:Q9UFR0|uniprotkb:Q59H66|uniprotkb:Q05BX7|uniprotkb:D3DQ57 intact:EBI-1044483|ensembl:ENSP00000293350|uniprotkb:C9JBH6|uniprotkb:Q86YF0|uniprotkb:Q8IYL4|uniprotkb:Q8TEI8|uniprotkb:B4DLQ1 psi-mi:ubp1_human(display_long)|uniprotkb:USP1(gene name)|psi-mi:USP1(display_short)|uniprotkb:Ubiquitin-specific-processing protease 1(gene name synonym)|uniprotkb:Deubiquitinating enzyme 1(gene name synonym)|uniprotkb:Ubiquitin thioesterase 1(gene name synonym) psi-mi:a16a1_human(display_long)|uniprotkb:ALDH16A1(gene name)|psi-mi:ALDH16A1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513405|imex:IM-12079-31 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000162607(gene)|ensembl:ENST00000339950(transcript)|ensembl:ENST00000371146(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008233"(peptidase activity)|go:"GO:0009411"(response to UV)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035520"(monoubiquitinated protein deubiquitination)|go:"GO:0042769"(obsolete DNA damage response, detection of DNA damage)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR033815|interpro:IPR038765|mint:O94782|rcsb pdb:6DO5|rcsb pdb:7AY0|rcsb pdb:7AY1|rcsb pdb:7AY2|reactome:R-HSA-110314|reactome:R-HSA-6783310|refseq:NP_001017415.1|refseq:NP_001017416.1|refseq:NP_003359.3|dip:DIP-53609N ensembl:ENSG00000161618(gene)|ensembl:ENST00000293350(transcript)|go:"GO:0016020"(membrane)|go:"GO:0016620"(oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor)|interpro:IPR015590(Aldehyde dehydrogenase)|interpro:IPR016161(Aldehyde/histidinol dehydrogenase)|interpro:IPR016162(Aldehyde dehydrogenase, N-terminal)|interpro:IPR011408(Aldehyde dehydrogenase predicted, duplicated region)|interpro:IPR016163(Aldehyde dehydrogenase, C-terminal)|mint:Q8IZ83|refseq:NP_699160.2|refseq:NP_001138868.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2020/03/02 rogid:cSWX5JiI+vqbREjhCJeCGAiiVzE9606 rogid:BoCNAGkgDh2oJaclyaoXr117+iw9606 intact-crc:4EBAACE957B9BC40|rigid:6fDAfoC1Z0y+hER8/Gjb5vhvziQ false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O94782 uniprotkb:A6NMY6 intact:EBI-2513396|ensembl:ENSP00000343526|ensembl:ENSP00000360188|uniprotkb:Q9UNJ3|uniprotkb:A0PJ95|uniprotkb:Q9UFR0|uniprotkb:Q59H66|uniprotkb:Q05BX7|uniprotkb:D3DQ57 intact:EBI-2513389 psi-mi:ubp1_human(display_long)|uniprotkb:USP1(gene name)|psi-mi:USP1(display_short)|uniprotkb:Ubiquitin-specific-processing protease 1(gene name synonym)|uniprotkb:Deubiquitinating enzyme 1(gene name synonym)|uniprotkb:Ubiquitin thioesterase 1(gene name synonym) psi-mi:axa2l_human(display_long)|uniprotkb:ANXA2P2(gene name)|psi-mi:ANXA2P2(display_short)|uniprotkb:ANX2L2(gene name synonym)|uniprotkb:ANX2P2(gene name synonym)|uniprotkb:LPC2B(gene name synonym)|uniprotkb:Annexin A2 pseudogene 2(gene name synonym)|uniprotkb:Lipocortin II pseudogene(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513405|imex:IM-12079-31 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000162607(gene)|ensembl:ENST00000339950(transcript)|ensembl:ENST00000371146(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008233"(peptidase activity)|go:"GO:0009411"(response to UV)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035520"(monoubiquitinated protein deubiquitination)|go:"GO:0042769"(obsolete DNA damage response, detection of DNA damage)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR033815|interpro:IPR038765|mint:O94782|rcsb pdb:6DO5|rcsb pdb:7AY0|rcsb pdb:7AY1|rcsb pdb:7AY2|reactome:R-HSA-110314|reactome:R-HSA-6783310|refseq:NP_001017415.1|refseq:NP_001017416.1|refseq:NP_003359.3|dip:DIP-53609N go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0002020"(protease binding)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005544"(calcium-dependent phospholipid binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0019834"(phospholipase A2 inhibitor activity)|go:"GO:0031982"(vesicle)|go:"GO:0042470"(melanosome)|go:"GO:0046790"(virion binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001464(Annexin)|interpro:IPR018502|interpro:IPR018252|interpro:IPR002389(Annexin, type II)|mint:A6NMY6|interpro:IPR037104 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2020/03/02 rogid:cSWX5JiI+vqbREjhCJeCGAiiVzE9606 rogid:1dVlFkkFYmN/Yn3Kv7/sCStcX089606 intact-crc:4EBAACE957B9BC40|rigid:6fDAfoC1Z0y+hER8/Gjb5vhvziQ false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O94782 uniprotkb:Q08554 intact:EBI-2513396|ensembl:ENSP00000343526|ensembl:ENSP00000360188|uniprotkb:Q9UNJ3|uniprotkb:A0PJ95|uniprotkb:Q9UFR0|uniprotkb:Q59H66|uniprotkb:Q05BX7|uniprotkb:D3DQ57 intact:EBI-2371346|uniprotkb:Q9HB01|ensembl:ENSP00000257198 psi-mi:ubp1_human(display_long)|uniprotkb:USP1(gene name)|psi-mi:USP1(display_short)|uniprotkb:Ubiquitin-specific-processing protease 1(gene name synonym)|uniprotkb:Deubiquitinating enzyme 1(gene name synonym)|uniprotkb:Ubiquitin thioesterase 1(gene name synonym) psi-mi:dsc1_human(display_long)|uniprotkb:DSC1(gene name)|psi-mi:DSC1(display_short)|uniprotkb:CDHF1(gene name synonym)|uniprotkb:Desmosomal glycoprotein 2/3(gene name synonym)|uniprotkb:Cadherin family member 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513405|imex:IM-12079-31 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000162607(gene)|ensembl:ENST00000339950(transcript)|ensembl:ENST00000371146(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008233"(peptidase activity)|go:"GO:0009411"(response to UV)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035520"(monoubiquitinated protein deubiquitination)|go:"GO:0042769"(obsolete DNA damage response, detection of DNA damage)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR033815|interpro:IPR038765|mint:O94782|rcsb pdb:6DO5|rcsb pdb:7AY0|rcsb pdb:7AY1|rcsb pdb:7AY2|reactome:R-HSA-110314|reactome:R-HSA-6783310|refseq:NP_001017415.1|refseq:NP_001017416.1|refseq:NP_003359.3|dip:DIP-53609N refseq:NP_004939.1|refseq:NP_077739.1|ensembl:ENSG00000134765(gene)|ensembl:ENST00000257198(transcript)|go:"GO:0001533"(cornified envelope)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005921"(gap junction)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030057"(desmosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0101003"(ficolin-1-rich granule membrane)|interpro:IPR000233(Cadherin cytoplasmic region)|interpro:IPR002126(Cadherin)|interpro:IPR009122(Desmosomal cadherin)|interpro:IPR014868(Cadherin prodomain like)|interpro:IPR015919(Cadherin-like)|interpro:IPR020894|interpro:IPR027397|rcsb pdb:5IRY|reactome:R-HSA-6798695|reactome:R-HSA-6805567|reactome:R-HSA-6809371 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2020/03/02 rogid:cSWX5JiI+vqbREjhCJeCGAiiVzE9606 rogid:dxtPfdDnZFaelPwT5bV8k/ZobSw9606 intact-crc:4EBAACE957B9BC40|rigid:6fDAfoC1Z0y+hER8/Gjb5vhvziQ false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O94782 uniprotkb:P14923 intact:EBI-2513396|ensembl:ENSP00000343526|ensembl:ENSP00000360188|uniprotkb:Q9UNJ3|uniprotkb:A0PJ95|uniprotkb:Q9UFR0|uniprotkb:Q59H66|uniprotkb:Q05BX7|uniprotkb:D3DQ57 intact:EBI-702484|uniprotkb:Q15093|intact:EBI-988999|intact:EBI-744449|uniprotkb:Q9HCX9|uniprotkb:Q15151|uniprotkb:Q7L3S5|uniprotkb:Q86W21|uniprotkb:Q9BWC4|ensembl:ENSP00000311113|ensembl:ENSP00000377507|ensembl:ENSP00000377508 psi-mi:ubp1_human(display_long)|uniprotkb:USP1(gene name)|psi-mi:USP1(display_short)|uniprotkb:Ubiquitin-specific-processing protease 1(gene name synonym)|uniprotkb:Deubiquitinating enzyme 1(gene name synonym)|uniprotkb:Ubiquitin thioesterase 1(gene name synonym) psi-mi:plak_human(display_long)|uniprotkb:JUP(gene name)|psi-mi:JUP(display_short)|uniprotkb:DP3(gene name synonym)|uniprotkb:CTNNG(gene name synonym)|uniprotkb:Desmoplakin-3(gene name synonym)|uniprotkb:Desmoplakin III(gene name synonym)|uniprotkb:Catenin gamma(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513405|imex:IM-12079-31 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000162607(gene)|ensembl:ENST00000339950(transcript)|ensembl:ENST00000371146(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008233"(peptidase activity)|go:"GO:0009411"(response to UV)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035520"(monoubiquitinated protein deubiquitination)|go:"GO:0042769"(obsolete DNA damage response, detection of DNA damage)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR033815|interpro:IPR038765|mint:O94782|rcsb pdb:6DO5|rcsb pdb:7AY0|rcsb pdb:7AY1|rcsb pdb:7AY2|reactome:R-HSA-110314|reactome:R-HSA-6783310|refseq:NP_001017415.1|refseq:NP_001017416.1|refseq:NP_003359.3|dip:DIP-53609N refseq:NP_002221.1|refseq:NP_068831.1|refseq:XP_011523055.1|refseq:XP_011523057.1|refseq:XP_011523058.1|refseq:XP_011523059.1|refseq:XP_011523060.1|refseq:XP_006721936.1|refseq:XP_006721937.1|refseq:XP_006721938.1|refseq:XP_006721941.1|refseq:XP_016880079.1|dip:DIP-36235N|ensembl:ENSG00000173801(gene)|ensembl:ENST00000310706(transcript)|ensembl:ENST00000393930(transcript)|ensembl:ENST00000393931(transcript)|go:"GO:0001533"(cornified envelope)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002159"(desmosome assembly)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005882"(intermediate filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005915"(zonula adherens)|go:"GO:0005916"(fascia adherens)|go:"GO:0005925"(focal adhesion)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0014704"(intercalated disc)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016342"(catenin complex)|go:"GO:0016477"(cell migration)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030018"(Z disc)|go:"GO:0030057"(desmosome)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0035580"(specific granule lumen)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0043588"(skin development)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045294"(alpha-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050982"(detection of mechanical stimulus)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071603"(endothelial cell-cell adhesion)|go:"GO:0071665"(gamma-catenin-TCF7L2 complex)|go:"GO:0071681"(cellular response to indole-3-methanol)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0086073"(bundle of His cell-Purkinje myocyte adhesion involved in cell communication)|go:"GO:0086083"(cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098911"(regulation of ventricular cardiac muscle cell action potential)|go:"GO:0106006"(cytoskeletal protein-membrane anchor activity)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000225(Armadillo)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013284(Beta-catenin)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR030461|mint:P14923|rcsb pdb:3IFQ|reactome:R-HSA-418990|reactome:R-HSA-5218920|reactome:R-HSA-6798695|reactome:R-HSA-6805567|reactome:R-HSA-6809371|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013406|reactome:R-HSA-9013407|reactome:R-HSA-9013409 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2020/03/02 rogid:cSWX5JiI+vqbREjhCJeCGAiiVzE9606 rogid:qOBUlbifyKUk1xF0Zr9jZPkZozc9606 intact-crc:4EBAACE957B9BC40|rigid:6fDAfoC1Z0y+hER8/Gjb5vhvziQ false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9BXU7 uniprotkb:P0C7H9 intact:EBI-1641713|uniprotkb:Q5H9H4|uniprotkb:B9WRT6|ensembl:ENSP00000359869|ensembl:ENSP00000423390 intact:EBI-2511777|ensembl:ENSP00000485337 psi-mi:ubp26_human(display_long)|uniprotkb:USP26(gene name)|psi-mi:USP26(display_short)|uniprotkb:Ubiquitin-specific-processing protease 26(gene name synonym)|uniprotkb:Deubiquitinating enzyme 26(gene name synonym)|uniprotkb:Ubiquitin thioesterase 26(gene name synonym) psi-mi:u17l7_human(display_long)|uniprotkb:USP17L7(gene name)|psi-mi:USP17L7(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513514|imex:IM-12079-32 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_114113.1|refseq:XP_016885381.1|ensembl:ENSG00000134588(gene)|ensembl:ENST00000370832(transcript)|ensembl:ENST00000511190(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR032069|interpro:IPR038093|interpro:IPR038765|reactome:R-HSA-5689880 ensembl:ENSG00000226430(gene)|ensembl:ENST00000530447(transcript)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0042981"(regulation of apoptotic process)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|refseq:NP_001243798.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:ejKg9IMmhGLN9txVwvVS4QOo64s9606 rogid:eT+zdD3jiYQz3wkFFcifYzKnREw9606 intact-crc:DF032A070A97CF70|rigid:Z4bubhTF/6aHxIL65I5s0blxA04 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9HBJ7 uniprotkb:P07858 intact:EBI-2513526|ensembl:ENSP00000254181|ensembl:ENSP00000470747 intact:EBI-715062|uniprotkb:Q503A6|uniprotkb:Q96D87|uniprotkb:B3KRR5|uniprotkb:B3KQR5|ensembl:ENSP00000503300|ensembl:ENSP00000503435|ensembl:ENSP00000503487|ensembl:ENSP00000503513|ensembl:ENSP00000503578|ensembl:ENSP00000503608|ensembl:ENSP00000503652|ensembl:ENSP00000503674|ensembl:ENSP00000503858|ensembl:ENSP00000503909|ensembl:ENSP00000504161|ensembl:ENSP00000504226|ensembl:ENSP00000504336|ensembl:ENSP00000504480|ensembl:ENSP00000504638|ensembl:ENSP00000504659|ensembl:ENSP00000504797|ensembl:ENSP00000503280|ensembl:ENSP00000342070|ensembl:ENSP00000345672|ensembl:ENSP00000431143|ensembl:ENSP00000431518|ensembl:ENSP00000432077|ensembl:ENSP00000432244|ensembl:ENSP00000432408|ensembl:ENSP00000433215|ensembl:ENSP00000433379|ensembl:ENSP00000433929|ensembl:ENSP00000434217|ensembl:ENSP00000434725|ensembl:ENSP00000435074|ensembl:ENSP00000435105|ensembl:ENSP00000435260|ensembl:ENSP00000435886|ensembl:ENSP00000473301|ensembl:ENSP00000502963|ensembl:ENSP00000503006|ensembl:ENSP00000503052|ensembl:ENSP00000503078|ensembl:ENSP00000503174 psi-mi:ubp29_human(display_long)|uniprotkb:USP29(gene name)|psi-mi:USP29(display_short)|uniprotkb:Ubiquitin-specific-processing protease 29(gene name synonym)|uniprotkb:Deubiquitinating enzyme 29(gene name synonym)|uniprotkb:Ubiquitin thioesterase 29(gene name synonym) psi-mi:catb_human(display_long)|uniprotkb:Cathepsin B1(gene name synonym)|uniprotkb:APP secretase(gene name synonym)|uniprotkb:CTSB(gene name)|psi-mi:CTSB(display_short)|uniprotkb:CPSB(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513524|imex:IM-12079-83 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000131864(gene)|ensembl:ENST00000254181(transcript)|ensembl:ENST00000598197(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR032069|interpro:IPR033381|interpro:IPR038093|interpro:IPR038765|go:"GO:0005634"(nucleus)|refseq:NP_065954.1 refseq:NP_001899.1|refseq:NP_680090.1|refseq:NP_680091.1|refseq:NP_680092.1|refseq:NP_680093.1|refseq:XP_011542114.1|refseq:XP_016868586.1|refseq:XP_016868587.1|refseq:XP_016868588.1|refseq:XP_016868589.1|ensembl:ENST00000345125(transcript)|ensembl:ENST00000353047(transcript)|ensembl:ENST00000524654(transcript)|ensembl:ENST00000526481(transcript)|ensembl:ENST00000526645(transcript)|ensembl:ENST00000527215(transcript)|ensembl:ENST00000534382(transcript)|ensembl:ENST00000527243(transcript)|ensembl:ENST00000534510(transcript)|ensembl:ENST00000676691(transcript)|ensembl:ENST00000676755(transcript)|ensembl:ENST00000676825(transcript)|ensembl:ENST00000676843(transcript)|ensembl:ENST00000676952(transcript)|ensembl:ENST00000677082(transcript)|ensembl:ENST00000677366(transcript)|ensembl:ENST00000677415(transcript)|ensembl:ENST00000528965(transcript)|ensembl:ENST00000530296(transcript)|ensembl:ENST00000530640(transcript)|ensembl:ENST00000677418(transcript)|ensembl:ENST00000677544(transcript)|ensembl:ENST00000677650(transcript)|ensembl:ENST00000677671(transcript)|ensembl:ENST00000677819(transcript)|ensembl:ENST00000677873(transcript)|ensembl:ENST00000678092(transcript)|ensembl:ENST00000678145(transcript)|ensembl:ENST00000678242(transcript)|ensembl:ENST00000531089(transcript)|ensembl:ENST00000678357(transcript)|ensembl:ENST00000531502(transcript)|ensembl:ENST00000678615(transcript)|ensembl:ENST00000532392(transcript)|ensembl:ENST00000678929(transcript)|ensembl:ENST00000532656(transcript)|ensembl:ENST00000533455(transcript)|ensembl:ENST00000679051(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005622"(intracellular anatomical structure)|go:"GO:0005764"(lysosome)|go:"GO:0006508"(proteolysis)|go:"GO:0006590"(thyroid hormone generation)|go:"GO:0008233"(peptidase activity)|go:"GO:0008234"(cysteine-type peptidase activity)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030574"(collagen catabolic process)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0036021"(endolysosome lumen)|go:"GO:0042470"(melanosome)|go:"GO:0042981"(regulation of apoptotic process)|ensembl:ENST00000679128(transcript)|go:"GO:0043394"(proteoglycan binding)|ensembl:ENST00000679140(transcript)|go:"GO:0046697"(decidualization)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005518"(collagen binding)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097067"(cellular response to thyroid hormone stimulus)|ensembl:ENSG00000164733(gene)|interpro:IPR000169(Peptidase, cysteine peptidase active site)|interpro:IPR000668(Peptidase C1A, papain C-terminal)|interpro:IPR012599(Peptidase C1A, propeptide)|interpro:IPR025660|interpro:IPR025661|interpro:IPR038765|mint:P07858|rcsb pdb:1CSB|rcsb pdb:1GMY|rcsb pdb:1HUC|rcsb pdb:1PBH|rcsb pdb:2IPP|rcsb pdb:2PBH|rcsb pdb:3AI8|rcsb pdb:3CBJ|rcsb pdb:3CBK|rcsb pdb:3K9M|rcsb pdb:3PBH|rcsb pdb:5MBL|rcsb pdb:5MBM|rcsb pdb:6AY2|reactome:R-HSA-1442490|reactome:R-HSA-1679131|reactome:R-HSA-2022090|reactome:R-HSA-2132295|reactome:R-HSA-6798695|go:"GO:1904813"(ficolin-1-rich granule lumen)|refseq:XP_006716307.1|refseq:XP_006716308.1|dip:DIP-42785N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:wOhjVWvYbieKvRxKJtE9z+O4lW89606 rogid:TdxD7Gf4BmlJcfUSULihf9W3sKQ9606 intact-crc:28A3B185D540008A|rigid:FpCh/EG+lnIM83ekkZJ9efYXP5M false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NFA0 uniprotkb:Q96QK1 intact:EBI-2511075|ensembl:ENSP00000300896|intact:EBI-9091112|uniprotkb:Q7Z5T3|uniprotkb:Q9Y591|uniprotkb:Q9BX85 intact:EBI-1054634|uniprotkb:Q561W2|uniprotkb:Q9H016|uniprotkb:Q9H096|uniprotkb:Q9H4P3|uniprotkb:Q9H8J0|uniprotkb:Q9NRS7|uniprotkb:Q9NVG2|uniprotkb:Q9NX80|uniprotkb:Q9NZK2|ensembl:ENSP00000299138 psi-mi:ubp32_human(display_long)|uniprotkb:USP32(gene name)|psi-mi:USP32(display_short)|uniprotkb:USP10(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 32(gene name synonym)|uniprotkb:Deubiquitinating enzyme 32(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-60(gene name synonym)|uniprotkb:Ubiquitin thioesterase 32(gene name synonym) psi-mi:vps35_human(display_long)|uniprotkb:Vesicle protein sorting 35(gene name synonym)|uniprotkb:Maternal-embryonic 3(gene name synonym)|uniprotkb:VPS35(gene name)|psi-mi:VPS35(display_short)|uniprotkb:MEM3(gene name synonym)|uniprotkb:TCCCTA00141(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513538|imex:IM-12079-33 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000170832(gene)|ensembl:ENST00000300896(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016020"(membrane)|go:"GO:0016579"(protein deubiquitination)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR018200|interpro:IPR018247|interpro:IPR028889|interpro:IPR035927|interpro:IPR038765|interpro:IPR011992(EF-Hand type)|refseq:NP_115971.2|dip:DIP-53613N refseq:NP_060676.2|rcsb pdb:5F0J|rcsb pdb:5F0K|rcsb pdb:5F0L|rcsb pdb:5F0M|rcsb pdb:5F0P|rcsb pdb:5OSH|rcsb pdb:5OSI|rcsb pdb:7BLN|rcsb pdb:7BLO|reactome:R-HSA-3238698|ensembl:ENSG00000069329(gene)|ensembl:ENST00000299138(transcript)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0010008"(endosome membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0030904"(retromer complex)|go:"GO:0030906"(retromer, cargo-selective complex)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0032268"(regulation of cellular protein metabolic process)|go:"GO:0032456"(endocytic recycling)|go:"GO:0036010"(protein localization to endosome)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0043653"(mitochondrial fragmentation involved in apoptotic process)|go:"GO:0045056"(transcytosis)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0060161"(positive regulation of dopamine receptor signaling pathway)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0097422"(tubular endosome)|go:"GO:0099073"(mitochondrion-derived vesicle)|go:"GO:0099074"(mitochondrion to lysosome transport)|go:"GO:0099639"(neurotransmitter receptor transport, endosome to plasma membrane)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902823"(negative regulation of late endosome to lysosome transport)|go:"GO:1902950"(regulation of dendritic spine maintenance)|go:"GO:1903364"(positive regulation of cellular protein catabolic process)|go:"GO:1905606"(regulation of presynapse assembly)|go:"GO:2000331"(regulation of terminal button organization)|interpro:IPR005378(Vacuolar protein sorting-associated protein 35)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR042491|rcsb pdb:2R17|dip:DIP-29076N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:DOnkgvUHy/ldOL9DCSP8PJppAY09606 rogid:EXkMduDQKNCdp876vGF5vna9t389606 intact-crc:9CEA9B290680C2B6|rigid:/y9F6uNS7LvlqJ8ZqQzt6Tf2fLU false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NFA0 uniprotkb:P35125 intact:EBI-2511075|ensembl:ENSP00000300896|intact:EBI-9091112|uniprotkb:Q7Z5T3|uniprotkb:Q9Y591|uniprotkb:Q9BX85 intact:EBI-954564|uniprotkb:Q15634|uniprotkb:Q86WP6|uniprotkb:Q8IWT4|ensembl:ENSP00000250066|ensembl:ENSP00000460380 psi-mi:ubp32_human(display_long)|uniprotkb:USP32(gene name)|psi-mi:USP32(display_short)|uniprotkb:USP10(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 32(gene name synonym)|uniprotkb:Deubiquitinating enzyme 32(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-60(gene name synonym)|uniprotkb:Ubiquitin thioesterase 32(gene name synonym) psi-mi:ubp6_human(display_long)|uniprotkb:Ubiquitin-specific-processing protease 6(gene name synonym)|uniprotkb:Deubiquitinating enzyme 6(gene name synonym)|uniprotkb:Proto-oncogene TRE-2(gene name synonym)|uniprotkb:USP6(gene name)|psi-mi:USP6(display_short)|uniprotkb:TRE2(gene name synonym)|uniprotkb:HRP1(gene name synonym)|uniprotkb:Ubiquitin thioesterase 6(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513538|imex:IM-12079-33 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000170832(gene)|ensembl:ENST00000300896(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016020"(membrane)|go:"GO:0016579"(protein deubiquitination)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR018200|interpro:IPR018247|interpro:IPR028889|interpro:IPR035927|interpro:IPR038765|interpro:IPR011992(EF-Hand type)|refseq:NP_115971.2|dip:DIP-53613N refseq:NP_004496.2|ensembl:ENST00000250066(transcript)|ensembl:ENST00000574788(transcript)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0055037"(recycling endosome)|go:"GO:0060627"(regulation of vesicle-mediated transport)|go:"GO:0090630"(activation of GTPase activity)|interpro:IPR000195(RabGAP/TBC)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR035969|interpro:IPR038765|interpro:IPR028889|ensembl:ENSG00000129204(gene)|refseq:NP_001291213.1|refseq:XP_011522352.1|refseq:XP_011522353.1|refseq:XP_011522354.1|refseq:XP_011522355.1|refseq:XP_011522356.1|refseq:XP_011522357.1|refseq:XP_011522358.1|refseq:XP_011522361.1|refseq:XP_016880779.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:DOnkgvUHy/ldOL9DCSP8PJppAY09606 rogid:EjN7POQXOUGbHphIDgTYYBqptJE9606 intact-crc:9CEA9B290680C2B6|rigid:/y9F6uNS7LvlqJ8ZqQzt6Tf2fLU false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NFA0 uniprotkb:Q9Y241 intact:EBI-2511075|ensembl:ENSP00000300896|intact:EBI-9091112|uniprotkb:Q7Z5T3|uniprotkb:Q9Y591|uniprotkb:Q9BX85 intact:EBI-1051940|uniprotkb:Q9UFZ2|ensembl:ENSP00000319393|ensembl:ENSP00000402160 psi-mi:ubp32_human(display_long)|uniprotkb:USP32(gene name)|psi-mi:USP32(display_short)|uniprotkb:USP10(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 32(gene name synonym)|uniprotkb:Deubiquitinating enzyme 32(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-60(gene name synonym)|uniprotkb:Ubiquitin thioesterase 32(gene name synonym) psi-mi:hig1a_human(display_long)|uniprotkb:Hypoxia-inducible gene 1 protein(gene name synonym)|uniprotkb:HIGD1A(gene name)|psi-mi:HIGD1A(display_short)|uniprotkb:HIG1(gene name synonym)|uniprotkb:RCF1 homolog A(gene name synonym)|uniprotkb:HSPC010(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513538|imex:IM-12079-33 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000170832(gene)|ensembl:ENST00000300896(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016020"(membrane)|go:"GO:0016579"(protein deubiquitination)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR018200|interpro:IPR018247|interpro:IPR028889|interpro:IPR035927|interpro:IPR038765|interpro:IPR011992(EF-Hand type)|refseq:NP_115971.2|dip:DIP-53613N refseq:NP_001093138.1|refseq:NP_001093139.1|refseq:NP_054775.2|ensembl:ENSG00000181061(gene)|ensembl:ENST00000321331(transcript)|ensembl:ENST00000418900(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0070469"(respirasome)|go:"GO:0097250"(mitochondrial respirasome assembly)|interpro:IPR007667(Hypoxia induced protein conserved region)|mint:Q9Y241|rcsb pdb:2LOM|reactome:R-HSA-1234158 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:DOnkgvUHy/ldOL9DCSP8PJppAY09606 rogid:xFklQUZRMs1m+6gbSJu2tKVz0Dk9606 intact-crc:9CEA9B290680C2B6|rigid:/y9F6uNS7LvlqJ8ZqQzt6Tf2fLU false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NFA0 uniprotkb:Q14683 intact:EBI-2511075|ensembl:ENSP00000300896|intact:EBI-9091112|uniprotkb:Q7Z5T3|uniprotkb:Q9Y591|uniprotkb:Q9BX85 intact:EBI-80690|ensembl:ENSP00000323421|uniprotkb:O14995|uniprotkb:Q16351|uniprotkb:Q2M228 psi-mi:ubp32_human(display_long)|uniprotkb:USP32(gene name)|psi-mi:USP32(display_short)|uniprotkb:USP10(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 32(gene name synonym)|uniprotkb:Deubiquitinating enzyme 32(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-60(gene name synonym)|uniprotkb:Ubiquitin thioesterase 32(gene name synonym) psi-mi:smc1a_human(display_long)|uniprotkb:SMC1A(gene name)|psi-mi:SMC1A(display_short)|uniprotkb:DXS423E(gene name synonym)|uniprotkb:KIAA0178(gene name synonym)|uniprotkb:SB1.8(gene name synonym)|uniprotkb:SMC1(gene name synonym)|uniprotkb:SMC1L1(gene name synonym)|uniprotkb:Sb1.8(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513538|imex:IM-12079-33 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000170832(gene)|ensembl:ENST00000300896(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016020"(membrane)|go:"GO:0016579"(protein deubiquitination)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR018200|interpro:IPR018247|interpro:IPR028889|interpro:IPR035927|interpro:IPR038765|interpro:IPR011992(EF-Hand type)|refseq:NP_115971.2|dip:DIP-53613N ensembl:ENSG00000072501(gene)|ensembl:ENST00000322213(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000776"(kinetochore)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0007064"(mitotic sister chromatid cohesion)|go:"GO:0008278"(cohesin complex)|go:"GO:0009314"(response to radiation)|go:"GO:0016363"(nuclear matrix)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030893"(meiotic cohesin complex)|go:"GO:0036033"(mediator complex binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051301"(cell division)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0072423"(response to DNA damage checkpoint signaling)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:0097431"(mitotic spindle pole)|interpro:IPR003395(RecF/RecN/SMC protein, N-terminal)|interpro:IPR010935(SMCs flexible hinge)|interpro:IPR024704|interpro:IPR027417|interpro:IPR028468|interpro:IPR029683|interpro:IPR036277|mint:Q14683|rcsb pdb:6WG3|rcsb pdb:6WG4|rcsb pdb:6WG6|rcsb pdb:6WGE|reactome:R-HSA-1221632|reactome:R-HSA-2467813|reactome:R-HSA-2470946|reactome:R-HSA-2500257|reactome:R-HSA-3108214|reactome:R-HSA-9018519|reactome:R-HSA-2468052|refseq:NP_006297.2|dip:DIP-30911N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:DOnkgvUHy/ldOL9DCSP8PJppAY09606 rogid:0UhfA7txIetlcGvSes6d+Bv1ZdY9606 intact-crc:9CEA9B290680C2B6|rigid:/y9F6uNS7LvlqJ8ZqQzt6Tf2fLU false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NFA0 uniprotkb:Q71U36 intact:EBI-2511075|ensembl:ENSP00000300896|intact:EBI-9091112|uniprotkb:Q7Z5T3|uniprotkb:Q9Y591|uniprotkb:Q9BX85 intact:EBI-302552|uniprotkb:P04687|uniprotkb:P05209|uniprotkb:A8K0B8|uniprotkb:G3V1U9|intact:EBI-10989786|ensembl:ENSP00000301071|ensembl:ENSP00000439020 psi-mi:ubp32_human(display_long)|uniprotkb:USP32(gene name)|psi-mi:USP32(display_short)|uniprotkb:USP10(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 32(gene name synonym)|uniprotkb:Deubiquitinating enzyme 32(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-60(gene name synonym)|uniprotkb:Ubiquitin thioesterase 32(gene name synonym) psi-mi:tba1a_human(display_long)|uniprotkb:TUBA1A(gene name)|psi-mi:TUBA1A(display_short)|uniprotkb:Tubulin B-alpha-1(gene name synonym)|uniprotkb:Tubulin alpha-3 chain(gene name synonym)|uniprotkb:Alpha-tubulin 3(gene name synonym)|uniprotkb:TUBA3(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513538|imex:IM-12079-33 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000170832(gene)|ensembl:ENST00000300896(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016020"(membrane)|go:"GO:0016579"(protein deubiquitination)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR018200|interpro:IPR018247|interpro:IPR028889|interpro:IPR035927|interpro:IPR038765|interpro:IPR011992(EF-Hand type)|refseq:NP_115971.2|dip:DIP-53613N refseq:NP_006000.2|refseq:NP_001257328.1|refseq:NP_001257329.1|dip:DIP-32773N|ensembl:ENSG00000167552(gene)|ensembl:ENST00000295766(transcript)|ensembl:ENST00000301071(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0007017"(microtubule-based process)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030705"(cytoskeleton-dependent intracellular transport)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0043209"(myelin sheath)|go:"GO:0045121"(membrane raft)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0051301"(cell division)|go:"GO:0055037"(recycling endosome)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000217(Tubulin)|interpro:IPR002452(Alpha tubulin)|interpro:IPR003008(Tubulin/FtsZ, GTPase)|interpro:IPR008280(Tubulin/FtsZ, C-terminal)|interpro:IPR017975|interpro:IPR018316|interpro:IPR023123|interpro:IPR036525|interpro:IPR037103|mint:Q71U36|rcsb pdb:5JCO|rcsb pdb:6J8F|rcsb pdb:6WSL|rcsb pdb:7C1M|reactome:R-HSA-1445148|reactome:R-HSA-9646399|reactome:R-HSA-9648025|reactome:R-HSA-9668328|reactome:R-HSA-983189|reactome:R-HSA-190840|reactome:R-HSA-190861|reactome:R-HSA-2132295|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-2565942|reactome:R-HSA-3371497|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-389957|reactome:R-HSA-389960|reactome:R-HSA-389977|reactome:R-HSA-437239|reactome:R-HSA-5610787|reactome:R-HSA-5617833|reactome:R-HSA-5620912|reactome:R-HSA-5620924|reactome:R-HSA-5626467|reactome:R-HSA-5663220|reactome:R-HSA-6807878|reactome:R-HSA-6811434|reactome:R-HSA-6811436|reactome:R-HSA-68877|reactome:R-HSA-8852276|reactome:R-HSA-8854518|reactome:R-HSA-8955332|reactome:R-HSA-9609690|reactome:R-HSA-9609736|reactome:R-HSA-9619483 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:DOnkgvUHy/ldOL9DCSP8PJppAY09606 rogid:1CzEzrf5y8hrQRPKgWQS1Wm1aCY9606 intact-crc:9CEA9B290680C2B6|rigid:/y9F6uNS7LvlqJ8ZqQzt6Tf2fLU false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NFA0 uniprotkb:P06493 intact:EBI-2511075|ensembl:ENSP00000300896|intact:EBI-9091112|uniprotkb:Q7Z5T3|uniprotkb:Q9Y591|uniprotkb:Q9BX85 intact:EBI-444308|ensembl:ENSP00000378699|uniprotkb:O60764|uniprotkb:C9J497|uniprotkb:A8K7C4 psi-mi:ubp32_human(display_long)|uniprotkb:USP32(gene name)|psi-mi:USP32(display_short)|uniprotkb:USP10(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 32(gene name synonym)|uniprotkb:Deubiquitinating enzyme 32(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-60(gene name synonym)|uniprotkb:Ubiquitin thioesterase 32(gene name synonym) psi-mi:cdk1_human(display_long)|uniprotkb:p34 protein kinase(gene name synonym)|uniprotkb:Cell division protein kinase 1(gene name synonym)|uniprotkb:CDK1(gene name)|psi-mi:CDK1(display_short)|uniprotkb:CDC2(gene name synonym)|uniprotkb:Cell division control protein 2 homolog(gene name synonym)|uniprotkb:CDC28A(gene name synonym)|uniprotkb:CDKN1(gene name synonym)|uniprotkb:P34CDC2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513538|imex:IM-12079-33 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000170832(gene)|ensembl:ENST00000300896(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016020"(membrane)|go:"GO:0016579"(protein deubiquitination)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR018200|interpro:IPR018247|interpro:IPR028889|interpro:IPR035927|interpro:IPR038765|interpro:IPR011992(EF-Hand type)|refseq:NP_115971.2|dip:DIP-53613N go:"GO:0006281"(DNA repair)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007344"(pronuclear fusion)|go:"GO:0007569"(cell aging)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0014038"(regulation of Schwann cell differentiation)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014075"(response to amine)|go:"GO:0014823"(response to activity)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030261"(chromosome condensation)|go:"GO:0030332"(cyclin binding)|go:"GO:0030496"(midbody)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0034501"(protein localization to kinetochore)|go:"GO:0035173"(histone kinase activity)|go:"GO:0006260"(DNA replication)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0046688"(response to copper ion)|go:"GO:0048511"(rhythmic process)|go:"GO:0048678"(response to axon injury)|go:"GO:0051301"(cell division)|go:"GO:0055015"(ventricular cardiac muscle cell development)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0042493"|go:"GO:0072686"(mitotic spindle)|go:"GO:0090166"(Golgi disassembly)|go:"GO:0097125"(cyclin B1-CDK1 complex)|go:"GO:0097472"(cyclin-dependent protein kinase activity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1905448"(positive regulation of mitochondrial ATP synthesis coupled electron transport)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P06493|rcsb pdb:1LC9|rcsb pdb:4Y72|rcsb pdb:4YC3|rcsb pdb:4YC6|rcsb pdb:5HQ0|rcsb pdb:5LQF|rcsb pdb:6GU2|rcsb pdb:6GU3|rcsb pdb:6GU4|rcsb pdb:6GU6|go:"GO:0042752"(regulation of circadian rhythm)|rcsb pdb:6GU7|rcsb pdb:6TWN|reactome:R-HSA-110056|reactome:R-HSA-113507|reactome:R-HSA-1362300|reactome:R-HSA-162658|reactome:R-HSA-170145|reactome:R-HSA-174048|reactome:R-HSA-174184|reactome:R-HSA-176408|reactome:R-HSA-176412|reactome:R-HSA-176417|reactome:R-HSA-2299718|reactome:R-HSA-2465910|reactome:R-HSA-2500257|reactome:R-HSA-2514853|reactome:R-HSA-2565942|reactome:R-HSA-2980767|reactome:R-HSA-2995383|reactome:R-HSA-3301854|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-4419969|reactome:R-HSA-5620912|reactome:R-HSA-5687128|reactome:R-HSA-5689896|reactome:R-HSA-6804114|reactome:R-HSA-6804757|reactome:R-HSA-68875|reactome:R-HSA-69205|reactome:R-HSA-69273|reactome:R-HSA-69478|reactome:R-HSA-75035|reactome:R-HSA-8852276|reactome:R-HSA-8854518|reactome:R-HSA-8878166|ensembl:ENSG00000170312(gene)|ensembl:ENST00000395284(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001618"(virus receptor activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005876"(spindle microtubule)|refseq:NP_001777.1|refseq:NP_203698.1|refseq:XP_005270360.1|refseq:NP_001307847.1|dip:DIP-35N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:DOnkgvUHy/ldOL9DCSP8PJppAY09606 rogid:8geyXVp0Rpm8sG8I76/XgWsZ4JA9606 intact-crc:9CEA9B290680C2B6|rigid:/y9F6uNS7LvlqJ8ZqQzt6Tf2fLU false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NFA0 uniprotkb:Q15645 intact:EBI-2511075|ensembl:ENSP00000300896|intact:EBI-9091112|uniprotkb:Q7Z5T3|uniprotkb:Q9Y591|uniprotkb:Q9BX85 intact:EBI-358993|uniprotkb:C9K0T3|uniprotkb:O15324|ensembl:ENSP00000166345|uniprotkb:D3DTC0 psi-mi:ubp32_human(display_long)|uniprotkb:USP32(gene name)|psi-mi:USP32(display_short)|uniprotkb:USP10(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 32(gene name synonym)|uniprotkb:Deubiquitinating enzyme 32(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-60(gene name synonym)|uniprotkb:Ubiquitin thioesterase 32(gene name synonym) psi-mi:pch2_human(display_long)|uniprotkb:TRIP13(gene name)|psi-mi:TRIP13(display_short)|uniprotkb:Thyroid receptor-interacting protein 13(gene name synonym)|uniprotkb:PCH2(gene name synonym)|uniprotkb:Thyroid hormone receptor interactor 13(gene name synonym)|uniprotkb:Human papillomavirus type 16 E1 protein-binding protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513538|imex:IM-12079-33 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000170832(gene)|ensembl:ENST00000300896(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016020"(membrane)|go:"GO:0016579"(protein deubiquitination)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR018200|interpro:IPR018247|interpro:IPR028889|interpro:IPR035927|interpro:IPR038765|interpro:IPR011992(EF-Hand type)|refseq:NP_115971.2|dip:DIP-53613N refseq:NP_004228.1|ensembl:ENSG00000071539(gene)|ensembl:ENST00000166345(transcript)|go:"GO:0001556"(oocyte maturation)|go:"GO:0001673"(male germ cell nucleus)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|refseq:XP_011512465.1|dip:DIP-34493N|go:"GO:0005694"(chromosome)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007130"(synaptonemal complex assembly)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0007141"(male meiosis I)|go:"GO:0007144"(female meiosis I)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007286"(spermatid development)|go:"GO:0042802"(identical protein binding)|go:"GO:0048477"(oogenesis)|go:"GO:0051598"(meiotic recombination checkpoint signaling)|interpro:IPR001270(Chaperonin clpA/B)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR027417|interpro:IPR044539|mint:Q15645|rcsb pdb:5VQ9|rcsb pdb:5VQA|rcsb pdb:5WC2|rcsb pdb:6F0X|rcsb pdb:6LK0|rcsb pdb:7L9P psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:DOnkgvUHy/ldOL9DCSP8PJppAY09606 rogid:heF2f3R2lGIpZ80mZHnhMktXTE49606 intact-crc:9CEA9B290680C2B6|rigid:/y9F6uNS7LvlqJ8ZqQzt6Tf2fLU false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NFA0 uniprotkb:Q04323 intact:EBI-2511075|ensembl:ENSP00000300896|intact:EBI-9091112|uniprotkb:Q7Z5T3|uniprotkb:Q9Y591|uniprotkb:Q9BX85 intact:EBI-1058647|ensembl:ENSP00000303991|uniprotkb:Q9BV93|uniprotkb:Q9BVV5|intact:EBI-1993649 psi-mi:ubp32_human(display_long)|uniprotkb:USP32(gene name)|psi-mi:USP32(display_short)|uniprotkb:USP10(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 32(gene name synonym)|uniprotkb:Deubiquitinating enzyme 32(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-60(gene name synonym)|uniprotkb:Ubiquitin thioesterase 32(gene name synonym) psi-mi:ubxn1_human(display_long)|uniprotkb:UBXN1(gene name)|psi-mi:UBXN1(display_short)|uniprotkb:SAKS1(gene name synonym)|uniprotkb:SAPK substrate protein 1(gene name synonym)|uniprotkb:UBA/UBX 33.3 kDa protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513538|imex:IM-12079-33 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000170832(gene)|ensembl:ENST00000300896(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016020"(membrane)|go:"GO:0016579"(protein deubiquitination)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR018200|interpro:IPR018247|interpro:IPR028889|interpro:IPR035927|interpro:IPR038765|interpro:IPR011992(EF-Hand type)|refseq:NP_115971.2|dip:DIP-53613N ensembl:ENSG00000162191(gene)|ensembl:ENST00000301935(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0030425"(dendrite)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034098"(VCP-NPL4-UFD1 AAA ATPase complex)|go:"GO:0036435"(K48-linked polyubiquitin modification-dependent protein binding)|refseq:NP_001273006.1|refseq:NP_001273007.1|refseq:NP_056937.2|go:"GO:0043025"(neuronal cell body)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0051117"(ATPase binding)|go:"GO:0071796"(K6-linked polyubiquitin modification-dependent protein binding)|go:"GO:1903094"(negative regulation of protein K48-linked deubiquitination)|go:"GO:1904293"(negative regulation of ERAD pathway)|go:"GO:1904855"(proteasome regulatory particle binding)|go:"GO:2000157"(negative regulation of ubiquitin-specific protease activity)|interpro:IPR001012(UBX)|interpro:IPR009060(UBA-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR029071|interpro:IPR041923|reactome:R-HSA-532668|reactome:R-HSA-5693565|go:"GO:0043130"(ubiquitin binding)|refseq:XP_005274090.1|refseq:XP_016873363.1|dip:DIP-29467N psi-mi:"MI:0469"(intact) - crc64:E4E0C8BBAC93F2BB figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:DOnkgvUHy/ldOL9DCSP8PJppAY09606 rogid:KdHMRM9FSd6VT6MvJTxzdjARlRw9606 intact-crc:9CEA9B290680C2B6|rigid:/y9F6uNS7LvlqJ8ZqQzt6Tf2fLU false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NFA0 intact:EBI-2507574 intact:EBI-2511075|ensembl:ENSP00000300896|intact:EBI-9091112|uniprotkb:Q7Z5T3|uniprotkb:Q9Y591|uniprotkb:Q9BX85 uniparc:UPI0000D614B7 psi-mi:ubp32_human(display_long)|uniprotkb:USP32(gene name)|psi-mi:USP32(display_short)|uniprotkb:USP10(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 32(gene name synonym)|uniprotkb:Deubiquitinating enzyme 32(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-60(gene name synonym)|uniprotkb:Ubiquitin thioesterase 32(gene name synonym) psi-mi:ipi00397518(display_short)|psi-mi:EBI-2507574(display_long) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513538|imex:IM-12079-33 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000170832(gene)|ensembl:ENST00000300896(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016020"(membrane)|go:"GO:0016579"(protein deubiquitination)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR018200|interpro:IPR018247|interpro:IPR028889|interpro:IPR035927|interpro:IPR038765|interpro:IPR011992(EF-Hand type)|refseq:NP_115971.2|dip:DIP-53613N - psi-mi:"MI:0469"(intact) - no-uniprot-update:An amino acid sequence which is not represented in UniProt figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:DOnkgvUHy/ldOL9DCSP8PJppAY09606 rogid:9xpFsVKxRGm+65tkYYMaur8hqis9606 intact-crc:9CEA9B290680C2B6|rigid:/y9F6uNS7LvlqJ8ZqQzt6Tf2fLU false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NFA0 uniprotkb:P08727 intact:EBI-2511075|ensembl:ENSP00000300896|intact:EBI-9091112|uniprotkb:Q7Z5T3|uniprotkb:Q9Y591|uniprotkb:Q9BX85 intact:EBI-742756|uniprotkb:Q5XG83|uniprotkb:Q6NW33|uniprotkb:Q7L5M9|uniprotkb:Q96A53|uniprotkb:Q96FV1|uniprotkb:Q9BYF9|uniprotkb:Q9P1Y4|uniprotkb:B2R874|ensembl:ENSP00000355124 psi-mi:ubp32_human(display_long)|uniprotkb:USP32(gene name)|psi-mi:USP32(display_short)|uniprotkb:USP10(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 32(gene name synonym)|uniprotkb:Deubiquitinating enzyme 32(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-60(gene name synonym)|uniprotkb:Ubiquitin thioesterase 32(gene name synonym) psi-mi:k1c19_human(display_long)|uniprotkb:Cytokeratin-19(gene name synonym)|uniprotkb:Keratin-19(gene name synonym)|uniprotkb:KRT19(gene name)|psi-mi:KRT19(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513538|imex:IM-12079-33 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000170832(gene)|ensembl:ENST00000300896(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016020"(membrane)|go:"GO:0016579"(protein deubiquitination)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR018200|interpro:IPR018247|interpro:IPR028889|interpro:IPR035927|interpro:IPR038765|interpro:IPR011992(EF-Hand type)|refseq:NP_115971.2|dip:DIP-53613N refseq:NP_002267.2|ensembl:ENSG00000171345(gene)|ensembl:ENST00000361566(transcript)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005829"(cytosol)|go:"GO:0005882"(intermediate filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0008307"(structural constituent of muscle)|go:"GO:0016010"(dystrophin-associated glycoprotein complex)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0030018"(Z disc)|go:"GO:0042383"(sarcolemma)|go:"GO:0043034"(costamere)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045214"(sarcomere organization)|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071944"(cell periphery)|go:"GO:1990357"(terminal web)|interpro:IPR002957(Keratin, type I)|interpro:IPR018039|interpro:IPR039008|mint:P08727|reactome:R-HSA-6805567|reactome:R-HSA-6809371|dip:DIP-35655N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:DOnkgvUHy/ldOL9DCSP8PJppAY09606 rogid:fqsG2nghpcmTtI39LiYVLNYuFIA9606 intact-crc:9CEA9B290680C2B6|rigid:/y9F6uNS7LvlqJ8ZqQzt6Tf2fLU false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NFA0 uniprotkb:P28288 intact:EBI-2511075|ensembl:ENSP00000300896|intact:EBI-9091112|uniprotkb:Q7Z5T3|uniprotkb:Q9Y591|uniprotkb:Q9BX85 intact:EBI-80992|ensembl:ENSP00000359233|uniprotkb:Q15271|uniprotkb:Q9H529|uniprotkb:Q6NUN5|uniprotkb:Q96DA3|uniprotkb:D3DT46 psi-mi:ubp32_human(display_long)|uniprotkb:USP32(gene name)|psi-mi:USP32(display_short)|uniprotkb:USP10(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 32(gene name synonym)|uniprotkb:Deubiquitinating enzyme 32(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-60(gene name synonym)|uniprotkb:Ubiquitin thioesterase 32(gene name synonym) psi-mi:abcd3_human(display_long)|uniprotkb:ABCD3(gene name)|psi-mi:ABCD3(display_short)|uniprotkb:PMP70(gene name synonym)|uniprotkb:PXMP1(gene name synonym)|uniprotkb:70 kDa peroxisomal membrane protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513538|imex:IM-12079-33 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000170832(gene)|ensembl:ENST00000300896(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016020"(membrane)|go:"GO:0016579"(protein deubiquitination)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR018200|interpro:IPR018247|interpro:IPR028889|interpro:IPR035927|interpro:IPR038765|interpro:IPR011992(EF-Hand type)|refseq:NP_115971.2|dip:DIP-53613N ensembl:ENSG00000117528(gene)|ensembl:ENST00000370214(transcript)|go:"GO:0005324"(long-chain fatty acid transporter activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005777"(peroxisome)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0007031"(peroxisome organization)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0015910"(long-chain fatty acid import into peroxisome)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0042493"|go:"GO:0042626"(ATPase-coupled transmembrane transporter activity)|refseq:NP_001116146.1|refseq:NP_002849.1|go:"GO:0042760"(very long-chain fatty acid catabolic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043621"(protein self-association)|interpro:IPR003439(ABC transporter-like)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR005283(Peroxysomal long chain fatty acyl transporter)|interpro:IPR011527(ABC transporter, transmembrane region, type 1)|interpro:IPR017871|interpro:IPR027417|interpro:IPR036640|mint:P28288|reactome:R-HSA-1369062|reactome:R-HSA-8980692|reactome:R-HSA-9013106|reactome:R-HSA-9603798 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:DOnkgvUHy/ldOL9DCSP8PJppAY09606 rogid:aUTR1BDihIx1JxtsC5V4vmFAwA49606 intact-crc:9CEA9B290680C2B6|rigid:/y9F6uNS7LvlqJ8ZqQzt6Tf2fLU false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NFA0 uniprotkb:Q8N1G4 intact:EBI-2511075|ensembl:ENSP00000300896|intact:EBI-9091112|uniprotkb:Q7Z5T3|uniprotkb:Q9Y591|uniprotkb:Q9BX85 intact:EBI-2509921|ensembl:ENSP00000367498|uniprotkb:Q9ULN5 psi-mi:ubp32_human(display_long)|uniprotkb:USP32(gene name)|psi-mi:USP32(display_short)|uniprotkb:USP10(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 32(gene name synonym)|uniprotkb:Deubiquitinating enzyme 32(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-60(gene name synonym)|uniprotkb:Ubiquitin thioesterase 32(gene name synonym) psi-mi:lrc47_human(display_long)|uniprotkb:LRRC47(gene name)|psi-mi:LRRC47(display_short)|uniprotkb:KIAA1185(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513538|imex:IM-12079-33 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000170832(gene)|ensembl:ENST00000300896(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016020"(membrane)|go:"GO:0016579"(protein deubiquitination)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR018200|interpro:IPR018247|interpro:IPR028889|interpro:IPR035927|interpro:IPR038765|interpro:IPR011992(EF-Hand type)|refseq:NP_115971.2|dip:DIP-53613N ensembl:ENSG00000130764(gene)|ensembl:ENST00000378251(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004826"(phenylalanine-tRNA ligase activity)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR005146(B3/B4 tRNA-binding domain)|interpro:IPR020825|interpro:IPR025875|interpro:IPR032675|rcsb pdb:6ZXD|rcsb pdb:6ZXE|rcsb pdb:6ZXF|rcsb pdb:6ZXG|refseq:NP_065761.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:DOnkgvUHy/ldOL9DCSP8PJppAY09606 rogid:aPzU//EIwK8J4it97jCw/YyKFWU9606 intact-crc:9CEA9B290680C2B6|rigid:/y9F6uNS7LvlqJ8ZqQzt6Tf2fLU false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NFA0 uniprotkb:Q9NYK5 intact:EBI-2511075|ensembl:ENSP00000300896|intact:EBI-9091112|uniprotkb:Q7Z5T3|uniprotkb:Q9Y591|uniprotkb:Q9BX85 intact:EBI-2513042|ensembl:ENSP00000284967|uniprotkb:Q9BZV6|uniprotkb:Q32Q74|uniprotkb:Q9BSQ7|uniprotkb:Q5QTR3|uniprotkb:Q96Q65|uniprotkb:Q9NX44|uniprotkb:C9JYA5 psi-mi:ubp32_human(display_long)|uniprotkb:USP32(gene name)|psi-mi:USP32(display_short)|uniprotkb:USP10(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 32(gene name synonym)|uniprotkb:Deubiquitinating enzyme 32(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-60(gene name synonym)|uniprotkb:Ubiquitin thioesterase 32(gene name synonym) psi-mi:rm39_human(display_long)|uniprotkb:MRPL39(gene name)|psi-mi:MRPL39(display_short)|uniprotkb:C21orf92(gene name synonym)|uniprotkb:MRPL5(gene name synonym)|uniprotkb:RPML5(gene name synonym)|uniprotkb:39S ribosomal protein L5, mitochondrial(gene name synonym)|uniprotkb:MSTP003(orf name)|uniprotkb:PRED22(orf name)|uniprotkb:Mitochondrial large ribosomal subunit protein mL39(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513538|imex:IM-12079-33 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000170832(gene)|ensembl:ENST00000300896(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016020"(membrane)|go:"GO:0016579"(protein deubiquitination)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR018200|interpro:IPR018247|interpro:IPR028889|interpro:IPR035927|interpro:IPR038765|interpro:IPR011992(EF-Hand type)|refseq:NP_115971.2|dip:DIP-53613N ensembl:ENSG00000154719(gene)|ensembl:ENST00000352957(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005761"(mitochondrial ribosome)|go:"GO:0005762"(mitochondrial large ribosomal subunit)|interpro:IPR004095(TGS)|interpro:IPR012675(Beta-grasp fold, ferredoxin-type)|interpro:IPR012676(TGS-like)|interpro:IPR018163|mint:Q9NYK5|rcsb pdb:3J7Y|rcsb pdb:3J9M|rcsb pdb:5OOL|rcsb pdb:5OOM|rcsb pdb:6I9R|rcsb pdb:6NU2|rcsb pdb:6VLZ|rcsb pdb:6VMI|rcsb pdb:6ZM5|rcsb pdb:6ZM6|rcsb pdb:6ZS9|rcsb pdb:6ZSA|rcsb pdb:6ZSB|rcsb pdb:6ZSC|rcsb pdb:6ZSD|rcsb pdb:6ZSE|rcsb pdb:6ZSG|rcsb pdb:7A5F|rcsb pdb:7A5G|rcsb pdb:7A5H|rcsb pdb:7A5I|rcsb pdb:7A5J|rcsb pdb:7A5K|rcsb pdb:7L08|rcsb pdb:7L20|rcsb pdb:7O9K|rcsb pdb:7O9M|rcsb pdb:7ODR|rcsb pdb:7ODS|rcsb pdb:7ODT|rcsb pdb:7OF0|rcsb pdb:7OF2|rcsb pdb:7OF3|rcsb pdb:7OF4|rcsb pdb:7OF5|rcsb pdb:7OF6|rcsb pdb:7OF7|rcsb pdb:7OG4|reactome:R-HSA-5368286|reactome:R-HSA-5389840|reactome:R-HSA-5419276|rcsb pdb:6NU3|refseq:NP_059142.2|refseq:NP_542984.2|refseq:XP_006724089.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:DOnkgvUHy/ldOL9DCSP8PJppAY09606 rogid:yolHEKnYRC1KwprZYyWZXZmjgr89606 intact-crc:9CEA9B290680C2B6|rigid:/y9F6uNS7LvlqJ8ZqQzt6Tf2fLU false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NFA0 uniprotkb:Q9BS26 intact:EBI-2511075|ensembl:ENSP00000300896|intact:EBI-9091112|uniprotkb:Q7Z5T3|uniprotkb:Q9Y591|uniprotkb:Q9BX85 intact:EBI-541644|uniprotkb:O60319|uniprotkb:Q5VWZ7|uniprotkb:Q6UW14|uniprotkb:Q8WX67|intact:EBI-1054855|uniprotkb:Q4VXC1|ensembl:ENSP00000262455 psi-mi:ubp32_human(display_long)|uniprotkb:USP32(gene name)|psi-mi:USP32(display_short)|uniprotkb:USP10(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 32(gene name synonym)|uniprotkb:Deubiquitinating enzyme 32(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-60(gene name synonym)|uniprotkb:Ubiquitin thioesterase 32(gene name synonym) psi-mi:erp44_human(display_long)|uniprotkb:ERP44(gene name)|psi-mi:ERP44(display_short)|uniprotkb:UNQ532/PRO1075(orf name)|uniprotkb:TXNDC4(gene name synonym)|uniprotkb:Thioredoxin domain-containing protein 4(gene name synonym)|uniprotkb:KIAA0573(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513538|imex:IM-12079-33 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000170832(gene)|ensembl:ENST00000300896(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016020"(membrane)|go:"GO:0016579"(protein deubiquitination)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR018200|interpro:IPR018247|interpro:IPR028889|interpro:IPR035927|interpro:IPR038765|interpro:IPR011992(EF-Hand type)|refseq:NP_115971.2|dip:DIP-53613N ensembl:ENSG00000023318(gene)|ensembl:ENST00000262455(transcript)|go:"GO:0003756"(protein disulfide isomerase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0006457"(protein folding)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0009986"(cell surface)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035580"(specific granule lumen)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0070062"(extracellular exosome)|interpro:IPR013766(Thioredoxin domain)|interpro:IPR036249|interpro:IPR041862|interpro:IPR041870|mint:Q9BS26|rcsb pdb:2R2J|rcsb pdb:5GU6|rcsb pdb:5GU7|rcsb pdb:5HQP|rcsb pdb:5XWM|reactome:R-HSA-6798695|go:"GO:0009100"(glycoprotein metabolic process)|refseq:NP_055866.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:DOnkgvUHy/ldOL9DCSP8PJppAY09606 rogid:TpwaFRifveb03iRPS2pEZve1kLA9606 intact-crc:9CEA9B290680C2B6|rigid:/y9F6uNS7LvlqJ8ZqQzt6Tf2fLU false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NFA0 uniprotkb:P05787 intact:EBI-2511075|ensembl:ENSP00000300896|intact:EBI-9091112|uniprotkb:Q7Z5T3|uniprotkb:Q9Y591|uniprotkb:Q9BX85 intact:EBI-297852|uniprotkb:Q14099|uniprotkb:Q14716|uniprotkb:Q14717|uniprotkb:Q53GJ0|uniprotkb:Q6DHW5|uniprotkb:Q6GMY0|uniprotkb:Q6P4C7|uniprotkb:Q96J60|ensembl:ENSP00000293308|ensembl:ENSP00000447402|ensembl:ENSP00000447566|uniprotkb:A8K4H3|uniprotkb:B0AZN5|uniprotkb:F8VXB4 psi-mi:ubp32_human(display_long)|uniprotkb:USP32(gene name)|psi-mi:USP32(display_short)|uniprotkb:USP10(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 32(gene name synonym)|uniprotkb:Deubiquitinating enzyme 32(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-60(gene name synonym)|uniprotkb:Ubiquitin thioesterase 32(gene name synonym) psi-mi:k2c8_human(display_long)|uniprotkb:Keratin-8(gene name synonym)|uniprotkb:KRT8(gene name)|psi-mi:KRT8(display_short)|uniprotkb:CYK8(gene name synonym)|uniprotkb:Cytokeratin-8(gene name synonym)|uniprotkb:Type-II keratin Kb8(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513538|imex:IM-12079-33 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000170832(gene)|ensembl:ENST00000300896(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016020"(membrane)|go:"GO:0016579"(protein deubiquitination)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR018200|interpro:IPR018247|interpro:IPR028889|interpro:IPR035927|interpro:IPR038765|interpro:IPR011992(EF-Hand type)|refseq:NP_115971.2|dip:DIP-53613N refseq:NP_001243222.1|ensembl:ENSG00000170421(gene)|ensembl:ENST00000293308(transcript)|ensembl:ENST00000546897(transcript)|ensembl:ENST00000552551(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005882"(intermediate filament)|go:"GO:0005911"(cell-cell junction)|go:"GO:0016010"(dystrophin-associated glycoprotein complex)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0016363"(nuclear matrix)|go:"GO:0030018"(Z disc)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0042383"(sarcolemma)|go:"GO:0043034"(costamere)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045095"(keratin filament)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045214"(sarcomere organization)|go:"GO:0051599"(response to hydrostatic pressure)|go:"GO:0051707"(response to other organism)|go:"GO:0060706"(cell differentiation involved in embryonic placenta development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|interpro:IPR003054(Type II keratin)|interpro:IPR018039|interpro:IPR032444|interpro:IPR039008|mint:P05787|reactome:R-HSA-6805567|reactome:R-HSA-6809371|refseq:NP_002264.1|dip:DIP-424N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:DOnkgvUHy/ldOL9DCSP8PJppAY09606 rogid:zyV8eOjx426ehjJYK4jsizORUws9606 intact-crc:9CEA9B290680C2B6|rigid:/y9F6uNS7LvlqJ8ZqQzt6Tf2fLU false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NFA0 uniprotkb:P31946 intact:EBI-2511075|ensembl:ENSP00000300896|intact:EBI-9091112|uniprotkb:Q7Z5T3|uniprotkb:Q9Y591|uniprotkb:Q9BX85 intact:EBI-359815|uniprotkb:A8K9K2|uniprotkb:E1P616|ensembl:ENSP00000300161|ensembl:ENSP00000361930 psi-mi:ubp32_human(display_long)|uniprotkb:USP32(gene name)|psi-mi:USP32(display_short)|uniprotkb:USP10(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 32(gene name synonym)|uniprotkb:Deubiquitinating enzyme 32(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-60(gene name synonym)|uniprotkb:Ubiquitin thioesterase 32(gene name synonym) psi-mi:1433b_human(display_long)|uniprotkb:YWHAB(gene name)|psi-mi:YWHAB(display_short)|uniprotkb:Protein kinase C inhibitor protein 1(gene name synonym)|uniprotkb:Protein 1054(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513538|imex:IM-12079-33 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000170832(gene)|ensembl:ENST00000300896(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016020"(membrane)|go:"GO:0016579"(protein deubiquitination)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR018200|interpro:IPR018247|interpro:IPR028889|interpro:IPR035927|interpro:IPR038765|interpro:IPR011992(EF-Hand type)|refseq:NP_115971.2|dip:DIP-53613N refseq:NP_003395.1|refseq:NP_647539.1|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051220"(cytoplasmic sequestering of protein)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:P31946|rcsb pdb:2BQ0|rcsb pdb:2C23|rcsb pdb:4DNK|rcsb pdb:5N10|rcsb pdb:6A5Q|rcsb pdb:6BYK|rcsb pdb:6GN0|rcsb pdb:6GN8|rcsb pdb:6GNJ|rcsb pdb:6GNK|rcsb pdb:6GNN|rcsb pdb:6HEP|reactome:R-HSA-111447|reactome:R-HSA-1445148|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-170968|reactome:R-HSA-170984|reactome:R-HSA-2028269|reactome:R-HSA-392517|reactome:R-HSA-450385|reactome:R-HSA-450513|reactome:R-HSA-5625740|reactome:R-HSA-5628897|reactome:R-HSA-5673000|reactome:R-HSA-5674135|reactome:R-HSA-5675221|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-75035|reactome:R-HSA-9614399|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9660537|ensembl:ENSG00000166913(gene)|ensembl:ENST00000353703(transcript)|ensembl:ENST00000372839(transcript)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005774"(vacuolar membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006605"(protein targeting)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0016020"(membrane)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|refseq:XP_016883528.1|dip:DIP-743N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:DOnkgvUHy/ldOL9DCSP8PJppAY09606 rogid:rp43CodPzsPadWEPtbnpKFAVIIU9606 intact-crc:9CEA9B290680C2B6|rigid:/y9F6uNS7LvlqJ8ZqQzt6Tf2fLU false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NFA0 uniprotkb:Q9Y285 intact:EBI-2511075|ensembl:ENSP00000300896|intact:EBI-9091112|uniprotkb:Q7Z5T3|uniprotkb:Q9Y591|uniprotkb:Q9BX85 intact:EBI-725361|uniprotkb:Q9NSD8|uniprotkb:Q9Y4W8|uniprotkb:B4E363|ensembl:ENSP00000320309 psi-mi:ubp32_human(display_long)|uniprotkb:USP32(gene name)|psi-mi:USP32(display_short)|uniprotkb:USP10(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 32(gene name synonym)|uniprotkb:Deubiquitinating enzyme 32(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-60(gene name synonym)|uniprotkb:Ubiquitin thioesterase 32(gene name synonym) psi-mi:syfa_human(display_long)|uniprotkb:CML33(gene name synonym)|uniprotkb:FARSA(gene name)|psi-mi:FARSA(display_short)|uniprotkb:FARS(gene name synonym)|uniprotkb:FARSLA(gene name synonym)|uniprotkb:FARSL(gene name synonym)|uniprotkb:Phenylalanyl-tRNA synthetase alpha subunit(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513538|imex:IM-12079-33 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000170832(gene)|ensembl:ENST00000300896(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016020"(membrane)|go:"GO:0016579"(protein deubiquitination)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR018200|interpro:IPR018247|interpro:IPR028889|interpro:IPR035927|interpro:IPR038765|interpro:IPR011992(EF-Hand type)|refseq:NP_115971.2|dip:DIP-53613N refseq:NP_004452.1|ensembl:ENSG00000179115(gene)|ensembl:ENST00000314606(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004826"(phenylalanine-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006432"(phenylalanyl-tRNA aminoacylation)|go:"GO:0009328"(phenylalanine-tRNA ligase complex)|go:"GO:0016020"(membrane)|go:"GO:0051290"(protein heterotetramerization)|interpro:IPR002319(Phenylalanyl-tRNA synthetase, class IIc)|interpro:IPR004529(Phenylalanyl-tRNA synthetase, class IIc, alpha subunit)|interpro:IPR006195(Aminoacyl-tRNA synthetase, class II)|interpro:IPR036390|interpro:IPR040586|interpro:IPR040724|interpro:IPR040725|mint:Q9Y285|rcsb pdb:3L4G|reactome:R-HSA-379716|dip:DIP-53610N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:DOnkgvUHy/ldOL9DCSP8PJppAY09606 rogid:FpOCk4Mzmsb2CnIUwUKg5nRg7/U9606 intact-crc:9CEA9B290680C2B6|rigid:/y9F6uNS7LvlqJ8ZqQzt6Tf2fLU false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8NFA0 uniprotkb:P05783 intact:EBI-2511075|ensembl:ENSP00000300896|intact:EBI-9091112|uniprotkb:Q7Z5T3|uniprotkb:Q9Y591|uniprotkb:Q9BX85 intact:EBI-297888|uniprotkb:Q53G38|uniprotkb:Q5U0N8|uniprotkb:Q9BW26|ensembl:ENSP00000373487|ensembl:ENSP00000373489 psi-mi:ubp32_human(display_long)|uniprotkb:USP32(gene name)|psi-mi:USP32(display_short)|uniprotkb:USP10(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 32(gene name synonym)|uniprotkb:Deubiquitinating enzyme 32(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-60(gene name synonym)|uniprotkb:Ubiquitin thioesterase 32(gene name synonym) psi-mi:k1c18_human(display_long)|uniprotkb:KRT18(gene name)|psi-mi:KRT18(display_short)|uniprotkb:CYK18(gene name synonym)|uniprotkb:Keratin-18(gene name synonym)|uniprotkb:PIG46(orf name)|uniprotkb:Cytokeratin-18(gene name synonym)|uniprotkb:Cell proliferation-inducing gene 46 protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513538|imex:IM-12079-33 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000170832(gene)|ensembl:ENST00000300896(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016020"(membrane)|go:"GO:0016579"(protein deubiquitination)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR018200|interpro:IPR018247|interpro:IPR028889|interpro:IPR035927|interpro:IPR038765|interpro:IPR011992(EF-Hand type)|refseq:NP_115971.2|dip:DIP-53613N go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005882"(intermediate filament)|go:"GO:0005912"(adherens junction)|go:"GO:0007049"(cell cycle)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009750"(response to fructose)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034451"(centriolar satellite)|go:"GO:0043000"(Golgi to plasma membrane CFTR protein transport)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045095"(keratin filament)|go:"GO:0045104"(intermediate filament cytoskeleton organization)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070365"(hepatocyte differentiation)|go:"GO:0072497"(mesenchymal stem cell differentiation)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0098641"(cadherin binding involved in cell-cell adhesion)|go:"GO:1902488"(cholangiocyte apoptotic process)|interpro:IPR002957(Keratin, type I)|interpro:IPR018039|interpro:IPR027695|interpro:IPR039008|mint:P05783|reactome:R-HSA-6805567|reactome:R-HSA-6809371|ensembl:ENSG00000111057(gene)|ensembl:ENST00000388835(transcript)|ensembl:ENST00000388837(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005198"(structural molecule activity)|refseq:NP_000215.1|refseq:NP_954657.1|dip:DIP-633N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:DOnkgvUHy/ldOL9DCSP8PJppAY09606 rogid:6rtLZxuG0CSGcsCHEmkRKFVDeyo9606 intact-crc:9CEA9B290680C2B6|rigid:/y9F6uNS7LvlqJ8ZqQzt6Tf2fLU false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8TEY7 uniprotkb:Q13325 intact:EBI-719283|uniprotkb:Q8TEY6|uniprotkb:Q96AV6|uniprotkb:Q9H9F0|uniprotkb:Q9UPQ5|ensembl:ENSP00000350009|ensembl:ENSP00000359829 intact:EBI-725916|ensembl:ENSP00000360860|uniprotkb:Q5T7I9|uniprotkb:B4DDV1|uniprotkb:B2R5X9|uniprotkb:Q6IAX3 psi-mi:ubp33_human(display_long)|uniprotkb:Ubiquitin-specific-processing protease 33(gene name synonym)|uniprotkb:Deubiquitinating enzyme 33(gene name synonym)|uniprotkb:VHL-interacting deubiquitinating enzyme 1(gene name synonym)|uniprotkb:USP33(gene name)|psi-mi:USP33(display_short)|uniprotkb:KIAA1097(gene name synonym)|uniprotkb:VDU1(gene name synonym)|uniprotkb:Ubiquitin thioesterase 33(gene name synonym) psi-mi:ifit5_human(display_long)|uniprotkb:Retinoic acid- and interferon-inducible 58 kDa protein(gene name synonym)|uniprotkb:IFIT5(gene name)|psi-mi:IFIT5(display_short)|uniprotkb:RI58(gene name synonym)|uniprotkb:ISG58(gene name synonym)|uniprotkb:Interferon-induced 58 kDa protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513595|imex:IM-12079-84 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055832.3|refseq:NP_963918.1|refseq:NP_963920.1|ensembl:ENSG00000077254(gene)|ensembl:ENST00000357428(transcript)|ensembl:ENST00000370793(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006897"(endocytosis)|go:"GO:0007411"(axon guidance)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016477"(cell migration)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030891"(VCB complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0044297"(cell body)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051298"(centrosome duplication)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|interpro:IPR028889|interpro:IPR035927|interpro:IPR038765|mint:Q8TEY7|rcsb pdb:2UZG|reactome:R-HSA-5689880|reactome:R-HSA-9010553|go:"GO:0032092"(positive regulation of protein binding)|dip:DIP-48942N ensembl:ENSG00000152778(gene)|ensembl:ENST00000371795(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0000339"(RNA cap binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0032587"(ruffle membrane)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045071"(negative regulation of viral genome replication)|go:"GO:0045087"(innate immune response)|go:"GO:0045177"(apical part of cell)|go:"GO:0051607"(defense response to virus)|refseq:NP_036552.1|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013105(Tetratricopeptide TPR2)|interpro:IPR019734|interpro:IPR024125|rcsb pdb:3ZGQ|rcsb pdb:4HOQ|rcsb pdb:4HOR|rcsb pdb:4HOS|rcsb pdb:4HOT|rcsb pdb:4J0U|reactome:R-HSA-909733 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:x7/WErmM96OiTTqOz77Np53z1IE9606 rogid:DIke7nm+pnCyC8x6zjzUbLcbWs89606 intact-crc:62658A53101552E9|rigid:WhDcWH/gJxTLWLG+Dmy36VF5wX4 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8TEY7 uniprotkb:Q96KR1 intact:EBI-719283|uniprotkb:Q8TEY6|uniprotkb:Q96AV6|uniprotkb:Q9H9F0|uniprotkb:Q9UPQ5|ensembl:ENSP00000350009|ensembl:ENSP00000359829 intact:EBI-2513582|ensembl:ENSP00000265069|uniprotkb:Q9Y687|uniprotkb:Q6P5A3|uniprotkb:B2RNR5|uniprotkb:Q9H6V4|uniprotkb:Q3B7X5|uniprotkb:Q05C08|uniprotkb:Q9NTI1|uniprotkb:Q86UA0|intact:EBI-2560216 psi-mi:ubp33_human(display_long)|uniprotkb:Ubiquitin-specific-processing protease 33(gene name synonym)|uniprotkb:Deubiquitinating enzyme 33(gene name synonym)|uniprotkb:VHL-interacting deubiquitinating enzyme 1(gene name synonym)|uniprotkb:USP33(gene name)|psi-mi:USP33(display_short)|uniprotkb:KIAA1097(gene name synonym)|uniprotkb:VDU1(gene name synonym)|uniprotkb:Ubiquitin thioesterase 33(gene name synonym) psi-mi:zfr_human(display_long)|uniprotkb:ZFR(gene name)|psi-mi:ZFR(display_short)|uniprotkb:M-phase phosphoprotein homolog(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513595|imex:IM-12079-84 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055832.3|refseq:NP_963918.1|refseq:NP_963920.1|ensembl:ENSG00000077254(gene)|ensembl:ENST00000357428(transcript)|ensembl:ENST00000370793(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006897"(endocytosis)|go:"GO:0007411"(axon guidance)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016477"(cell migration)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030891"(VCB complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0044297"(cell body)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051298"(centrosome duplication)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|interpro:IPR028889|interpro:IPR035927|interpro:IPR038765|mint:Q8TEY7|rcsb pdb:2UZG|reactome:R-HSA-5689880|reactome:R-HSA-9010553|go:"GO:0032092"(positive regulation of protein binding)|dip:DIP-48942N ensembl:ENSG00000056097(gene)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0008270"(zinc ion binding)|interpro:IPR003604(Zinc finger, U1-type)|interpro:IPR006561(DZF)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|interpro:IPR043519|mint:Q96KR1|ensembl:ENST00000265069(transcript)|refseq:NP_057191.2|ensembl:ENSP00000265069|dip:DIP-47293N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:x7/WErmM96OiTTqOz77Np53z1IE9606 rogid:UQQP+tkUcQYka9ez6rMv2F6FXFM9606 intact-crc:62658A53101552E9|rigid:WhDcWH/gJxTLWLG+Dmy36VF5wX4 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8TEY7 uniprotkb:Q13601 intact:EBI-719283|uniprotkb:Q8TEY6|uniprotkb:Q96AV6|uniprotkb:Q9H9F0|uniprotkb:Q9UPQ5|ensembl:ENSP00000350009|ensembl:ENSP00000359829 intact:EBI-744525|intact:EBI-28971604|ensembl:ENSP00000229214|uniprotkb:Q8NEA8|uniprotkb:Q8TC37|uniprotkb:Q96AT5|uniprotkb:A0FIK6|uniprotkb:A0JLP0|uniprotkb:B2R989|uniprotkb:E7EUQ0 psi-mi:ubp33_human(display_long)|uniprotkb:Ubiquitin-specific-processing protease 33(gene name synonym)|uniprotkb:Deubiquitinating enzyme 33(gene name synonym)|uniprotkb:VHL-interacting deubiquitinating enzyme 1(gene name synonym)|uniprotkb:USP33(gene name)|psi-mi:USP33(display_short)|uniprotkb:KIAA1097(gene name synonym)|uniprotkb:VDU1(gene name synonym)|uniprotkb:Ubiquitin thioesterase 33(gene name synonym) psi-mi:krr1_human(display_long)|uniprotkb:HIV-1 Rev-binding protein 2(gene name synonym)|uniprotkb:Rev-interacting protein 1(gene name synonym)|uniprotkb:KRR1(gene name)|psi-mi:KRR1(display_short)|uniprotkb:HRB2(gene name synonym)|uniprotkb:KRR-R motif-containing protein 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513595|imex:IM-12079-84 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055832.3|refseq:NP_963918.1|refseq:NP_963920.1|ensembl:ENSG00000077254(gene)|ensembl:ENST00000357428(transcript)|ensembl:ENST00000370793(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006897"(endocytosis)|go:"GO:0007411"(axon guidance)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016477"(cell migration)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030891"(VCB complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0044297"(cell body)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051298"(centrosome duplication)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|interpro:IPR028889|interpro:IPR035927|interpro:IPR038765|mint:Q8TEY7|rcsb pdb:2UZG|reactome:R-HSA-5689880|reactome:R-HSA-9010553|go:"GO:0032092"(positive regulation of protein binding)|dip:DIP-48942N ensembl:ENSP00000229214|ensembl:ENST00000438169|ensembl:ENSP00000411740|ensembl:ENSG00000111615(gene)|ensembl:ENST00000229214(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006364"(rRNA processing)|go:"GO:0016020"(membrane)|go:"GO:0032040"(small-subunit processome)|go:"GO:0045171"(intercellular bridge)|interpro:IPR004087(K Homology)|interpro:IPR024166|interpro:IPR036612|interpro:IPR041174|mint:Q13601|refseq:NP_008974.5|reactome:R-HSA-6790901|reactome:R-HSA-6791226 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:x7/WErmM96OiTTqOz77Np53z1IE9606 rogid:uBKNL/aw4wEssKJulbqQVWcH7ZI9606 intact-crc:62658A53101552E9|rigid:WhDcWH/gJxTLWLG+Dmy36VF5wX4 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8TEY7 uniprotkb:Q5VTL8 intact:EBI-719283|uniprotkb:Q8TEY6|uniprotkb:Q96AV6|uniprotkb:Q9H9F0|uniprotkb:Q9UPQ5|ensembl:ENSP00000350009|ensembl:ENSP00000359829 intact:EBI-1045334|uniprotkb:Q05DD6|uniprotkb:Q32Q58|uniprotkb:Q5VTL9|uniprotkb:Q6PK39|uniprotkb:Q7Z6E2|uniprotkb:Q86WF3|uniprotkb:Q8IWG9|uniprotkb:Q9NW40|ensembl:ENSP00000359042 psi-mi:ubp33_human(display_long)|uniprotkb:Ubiquitin-specific-processing protease 33(gene name synonym)|uniprotkb:Deubiquitinating enzyme 33(gene name synonym)|uniprotkb:VHL-interacting deubiquitinating enzyme 1(gene name synonym)|uniprotkb:USP33(gene name)|psi-mi:USP33(display_short)|uniprotkb:KIAA1097(gene name synonym)|uniprotkb:VDU1(gene name synonym)|uniprotkb:Ubiquitin thioesterase 33(gene name synonym) psi-mi:pr38b_human(display_long)|uniprotkb:Sarcoma antigen NY-SAR-27(gene name synonym)|uniprotkb:PRPF38B(gene name)|psi-mi:PRPF38B(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513595|imex:IM-12079-84 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055832.3|refseq:NP_963918.1|refseq:NP_963920.1|ensembl:ENSG00000077254(gene)|ensembl:ENST00000357428(transcript)|ensembl:ENST00000370793(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006897"(endocytosis)|go:"GO:0007411"(axon guidance)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016477"(cell migration)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030891"(VCB complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0044297"(cell body)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051298"(centrosome duplication)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|interpro:IPR028889|interpro:IPR035927|interpro:IPR038765|mint:Q8TEY7|rcsb pdb:2UZG|reactome:R-HSA-5689880|reactome:R-HSA-9010553|go:"GO:0032092"(positive regulation of protein binding)|dip:DIP-48942N refseq:NP_060531.2|ensembl:ENSG00000134186(gene)|ensembl:ENST00000370025(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0071011"(precatalytic spliceosome)|interpro:IPR005037(PRP38) psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:x7/WErmM96OiTTqOz77Np53z1IE9606 rogid:AWwws/iWEHoeyV7o3bgLKBQKgQ49606 intact-crc:62658A53101552E9|rigid:WhDcWH/gJxTLWLG+Dmy36VF5wX4 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q86T82 uniprotkb:Q9NSB2 intact:EBI-2513613|intact:EBI-2514223|uniprotkb:B7ZM38|uniprotkb:B7ZM41|uniprotkb:Q7Z3A5|uniprotkb:E9PHL3|uniprotkb:Q2KHT2|ensembl:ENSP00000258399|ensembl:ENSP00000393662|ensembl:ENSP00000396585|uniprotkb:Q9HCH8|uniprotkb:A2RUQ8|uniprotkb:Q53S10 intact:EBI-2372509|uniprotkb:B2RA43|uniprotkb:Q6ISB0|uniprotkb:Q701L6|ensembl:ENSP00000257951 psi-mi:ubp37_human(display_long)|uniprotkb:USP37(gene name)|psi-mi:USP37(display_short)|uniprotkb:KIAA1594(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 37(gene name synonym)|uniprotkb:Deubiquitinating enzyme 37(gene name synonym)|uniprotkb:Ubiquitin thioesterase 37(gene name synonym) psi-mi:krt84_human(display_long)|uniprotkb:KRT84(gene name)|psi-mi:KRT84(display_short)|uniprotkb:KRTHB4(gene name synonym)|uniprotkb:Type II hair keratin Hb4(gene name synonym)|uniprotkb:Keratin-84(gene name synonym)|uniprotkb:Type-II keratin Kb24(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513611|imex:IM-12079-34 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019901"(protein kinase binding)|go:"GO:0035871"(protein K11-linked deubiquitination)|go:"GO:0051301"(cell division)|go:"GO:0071108"(protein K48-linked deubiquitination)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR018200|interpro:IPR028889|interpro:IPR032069|interpro:IPR038093|go:"GO:0005829"(cytosol)|interpro:IPR038765|rcsb pdb:3U12|reactome:R-HSA-5689880|ensembl:ENSG00000135913(gene)|ensembl:ENST00000258399(transcript)|ensembl:ENST00000418019(transcript)|ensembl:ENST00000454775(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|refseq:XP_011509840.1|refseq:NP_065986.2|refseq:XP_005246777.1|refseq:XP_005246778.1|refseq:XP_005246779.1 refseq:XP_011536637.1|refseq:NP_149034.2|ensembl:ENSG00000161849(gene)|ensembl:ENST00000257951(transcript)|go:"GO:0001942"(hair follicle development)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005829"(cytosol)|go:"GO:0030280"(structural constituent of skin epidermis)|go:"GO:0035878"(nail development)|go:"GO:0045095"(keratin filament)|go:"GO:0045616"(regulation of keratinocyte differentiation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR003054(Type II keratin)|interpro:IPR018039|interpro:IPR032444|interpro:IPR039008|reactome:R-HSA-6805567|reactome:R-HSA-6809371 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:2DOjCrilHkv+l0r0zBQ1td2p+qc9606 rogid:j3FNHjfONdOzxrg2vXRURLaRoHI9606 intact-crc:FB381AAB0D76A6D5|rigid:KPHYQSm84fUJVD5Rjp+mjvcVL5w false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q86T82 uniprotkb:Q9UKB1 intact:EBI-2513613|intact:EBI-2514223|uniprotkb:B7ZM38|uniprotkb:B7ZM41|uniprotkb:Q7Z3A5|uniprotkb:E9PHL3|uniprotkb:Q2KHT2|ensembl:ENSP00000258399|ensembl:ENSP00000393662|ensembl:ENSP00000396585|uniprotkb:Q9HCH8|uniprotkb:A2RUQ8|uniprotkb:Q53S10 intact:EBI-355189|uniprotkb:Q9P2S8|uniprotkb:Q9P2S9|uniprotkb:Q9Y4C6|uniprotkb:B2RC98|ensembl:ENSP00000265094 psi-mi:ubp37_human(display_long)|uniprotkb:USP37(gene name)|psi-mi:USP37(display_short)|uniprotkb:KIAA1594(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 37(gene name synonym)|uniprotkb:Deubiquitinating enzyme 37(gene name synonym)|uniprotkb:Ubiquitin thioesterase 37(gene name synonym) psi-mi:fbw1b_human(display_long)|uniprotkb:KIAA0696(gene name synonym)|uniprotkb:FBXW11(gene name)|psi-mi:FBXW11(display_short)|uniprotkb:BTRCP2(gene name synonym)|uniprotkb:FBW1B(gene name synonym)|uniprotkb:FBXW1B(gene name synonym)|uniprotkb:F-box/WD repeat-containing protein 1B(gene name synonym)|uniprotkb:F-box and WD repeats protein beta-TrCP2(gene name synonym)|uniprotkb:Homologous to Slimb protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513611|imex:IM-12079-34 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019901"(protein kinase binding)|go:"GO:0035871"(protein K11-linked deubiquitination)|go:"GO:0051301"(cell division)|go:"GO:0071108"(protein K48-linked deubiquitination)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR018200|interpro:IPR028889|interpro:IPR032069|interpro:IPR038093|go:"GO:0005829"(cytosol)|interpro:IPR038765|rcsb pdb:3U12|reactome:R-HSA-5689880|ensembl:ENSG00000135913(gene)|ensembl:ENST00000258399(transcript)|ensembl:ENST00000418019(transcript)|ensembl:ENST00000454775(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|refseq:XP_011509840.1|refseq:NP_065986.2|refseq:XP_005246777.1|refseq:XP_005246778.1|refseq:XP_005246779.1 refseq:NP_036432.2|refseq:NP_387448.2|refseq:NP_387449.2|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007097"(nuclear migration)|go:"GO:0007281"(germ cell development)|go:"GO:0008090"(retrograde axonal transport)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031023"(microtubule organizing center organization)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031648"(protein destabilization)|go:"GO:0042753"(positive regulation of circadian rhythm)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0005635"(nuclear envelope)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0070840"(dynein complex binding)|go:"GO:1904115"(axon cytoplasm)|go:"GO:2000574"(obsolete regulation of microtubule motor activity)|interpro:IPR001680(WD40 repeat)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR021977|interpro:IPR036047|interpro:IPR036322|mint:Q9UKB1|rcsb pdb:6WNX|reactome:R-HSA-1169091|reactome:R-HSA-202424|reactome:R-HSA-2565942|reactome:R-HSA-2871837|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5676590|reactome:R-HSA-5684264|reactome:R-HSA-8951664|reactome:R-HSA-983168|go:"GO:0048511"(rhythmic process)|ensembl:ENSG00000072803(gene)|ensembl:ENST00000265094(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000776"(kinetochore)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|dip:DIP-27593N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:2DOjCrilHkv+l0r0zBQ1td2p+qc9606 rogid:8wLc2Pt+mLfRsNwXOnjho+1A0u09606 intact-crc:FB381AAB0D76A6D5|rigid:KPHYQSm84fUJVD5Rjp+mjvcVL5w false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q86T82 uniprotkb:P02768 intact:EBI-2513613|intact:EBI-2514223|uniprotkb:B7ZM38|uniprotkb:B7ZM41|uniprotkb:Q7Z3A5|uniprotkb:E9PHL3|uniprotkb:Q2KHT2|ensembl:ENSP00000258399|ensembl:ENSP00000393662|ensembl:ENSP00000396585|uniprotkb:Q9HCH8|uniprotkb:A2RUQ8|uniprotkb:Q53S10 intact:EBI-714423|ensembl:ENSP00000295897|uniprotkb:Q645G4|uniprotkb:O95574|uniprotkb:P04277|uniprotkb:Q13140|uniprotkb:Q68DN5|uniprotkb:Q6UXK4|uniprotkb:Q86YG0|uniprotkb:Q9P157|uniprotkb:Q9P1I7|uniprotkb:Q9UHS3|uniprotkb:Q9UJZ0|intact:EBI-7301844|intact:MINT-1161169|uniprotkb:E7ESS9|uniprotkb:Q8IUK7 psi-mi:ubp37_human(display_long)|uniprotkb:USP37(gene name)|psi-mi:USP37(display_short)|uniprotkb:KIAA1594(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 37(gene name synonym)|uniprotkb:Deubiquitinating enzyme 37(gene name synonym)|uniprotkb:Ubiquitin thioesterase 37(gene name synonym) psi-mi:albu_human(display_long)|uniprotkb:GIG42(orf name)|uniprotkb:ALB(gene name)|psi-mi:ALB(display_short)|uniprotkb:PRO0903(orf name)|uniprotkb:PRO1708(orf name)|uniprotkb:PRO2044(orf name)|uniprotkb:PRO2619(orf name)|uniprotkb:PRO2675(orf name)|uniprotkb:UNQ696/PRO1341(orf name)|uniprotkb:GIG20(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513611|imex:IM-12079-34 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019901"(protein kinase binding)|go:"GO:0035871"(protein K11-linked deubiquitination)|go:"GO:0051301"(cell division)|go:"GO:0071108"(protein K48-linked deubiquitination)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR018200|interpro:IPR028889|interpro:IPR032069|interpro:IPR038093|go:"GO:0005829"(cytosol)|interpro:IPR038765|rcsb pdb:3U12|reactome:R-HSA-5689880|ensembl:ENSG00000135913(gene)|ensembl:ENST00000258399(transcript)|ensembl:ENST00000418019(transcript)|ensembl:ENST00000454775(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|refseq:XP_011509840.1|refseq:NP_065986.2|refseq:XP_005246777.1|refseq:XP_005246778.1|refseq:XP_005246779.1 ensembl:ENSG00000163631(gene)|ensembl:ENST00000295897(transcript)|go:"GO:0001895"(retina homeostasis)|go:"GO:0003677"(DNA binding)|go:"GO:0005504"(fatty acid binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|rcsb pdb:1E78|go:"GO:0005634"(nucleus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0015643"(toxic substance binding)|go:"GO:0016209"(antioxidant activity)|go:"GO:0030170"(pyridoxal phosphate binding)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043069"(negative regulation of programmed cell death)|go:"GO:0051087"(chaperone binding)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0051659"(maintenance of mitochondrion location)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0140272"(exogenous protein binding)|go:"GO:1903981"(enterobactin binding)|interpro:IPR000264(Serum albumin)|interpro:IPR014760(Serum albumin, N-terminal)|interpro:IPR020857|interpro:IPR020858|interpro:IPR021177|mint:P02768|rcsb pdb:1AO6|rcsb pdb:1BJ5|rcsb pdb:1BKE|rcsb pdb:1BM0|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|rcsb pdb:6XV0|rcsb pdb:6YG9|rcsb pdb:6ZL1|rcsb pdb:7A9C|rcsb pdb:7AAE|rcsb pdb:7AAI|rcsb pdb:7D6J|rcsb pdb:7JWN|reactome:R-HSA-114608|reactome:R-HSA-159418|reactome:R-HSA-189451|reactome:R-HSA-189483|reactome:R-HSA-2168880|reactome:R-HSA-381426|reactome:R-HSA-879518|reactome:R-HSA-8957275|reactome:R-HSA-8964058|reactome:R-HSA-9707564|rcsb pdb:6WUW|rcsb pdb:1E7B|rcsb pdb:1E7C|rcsb pdb:1E7E|rcsb pdb:1E7F|rcsb pdb:1E7G|rcsb pdb:1E7H|rcsb pdb:1E7I|rcsb pdb:1GNI|rcsb pdb:1GNJ|rcsb pdb:1H9Z|rcsb pdb:1HA2|rcsb pdb:1HK1|rcsb pdb:1HK2|rcsb pdb:1HK3|rcsb pdb:1HK4|rcsb pdb:1HK5|rcsb pdb:1N5U|rcsb pdb:1O9X|rcsb pdb:1TF0|rcsb pdb:1UOR|rcsb pdb:1YSX|rcsb pdb:2BX8|rcsb pdb:2BXA|rcsb pdb:2BXB|rcsb pdb:2BXC|rcsb pdb:2BXD|rcsb pdb:1E7A|rcsb pdb:2BXE|rcsb pdb:2BXF|rcsb pdb:2BXG|rcsb pdb:2BXH|rcsb pdb:2BXI|rcsb pdb:2BXK|rcsb pdb:2BXL|rcsb pdb:2BXM|rcsb pdb:2BXN|rcsb pdb:2BXO|rcsb pdb:2BXP|rcsb pdb:2BXQ|rcsb pdb:2ESG|rcsb pdb:2I2Z|rcsb pdb:2I30|rcsb pdb:2N0X|rcsb pdb:2VDB|rcsb pdb:2VUE|rcsb pdb:2VUF|rcsb pdb:2XSI|rcsb pdb:2XVQ|rcsb pdb:2XVU|rcsb pdb:2XVV|rcsb pdb:2XVW|rcsb pdb:2XW0|rcsb pdb:2XW1|rcsb pdb:2YDF|rcsb pdb:3A73|rcsb pdb:3B9L|rcsb pdb:3B9M|rcsb pdb:3CX9|rcsb pdb:3JQZ|rcsb pdb:3JRY|rcsb pdb:3LU6|rcsb pdb:4HGM|rcsb pdb:4IW1|rcsb pdb:4IW2|rcsb pdb:4K2C|rcsb pdb:4K71|rcsb pdb:4L8U|rcsb pdb:4L9K|rcsb pdb:4L9Q|rcsb pdb:4LA0|rcsb pdb:4LB2|rcsb pdb:4LB9|rcsb pdb:4N0F|rcsb pdb:4N0U|rcsb pdb:4S1Y|rcsb pdb:4Z69|rcsb pdb:5FUO|rcsb pdb:5GIX|rcsb pdb:5GIY|rcsb pdb:5ID7|rcsb pdb:5IFO|rcsb pdb:5IJF|rcsb pdb:5UJB|rcsb pdb:5VNW|rcsb pdb:5X52|rcsb pdb:5YB1|rcsb pdb:5YOQ|rcsb pdb:5Z0B|rcsb pdb:6A7P|rcsb pdb:6EZQ|rcsb pdb:6HSC|rcsb pdb:6JE7|rcsb pdb:6L4K|rcsb pdb:6M4R|rcsb pdb:3LU7|rcsb pdb:3LU8|rcsb pdb:3SQJ|rcsb pdb:3TDL|rcsb pdb:3UIV|rcsb pdb:4BKE|rcsb pdb:4E99|rcsb pdb:4EMX|rcsb pdb:4G03|rcsb pdb:4G04|rcsb pdb:4HGK|rcsb pdb:6M58|rcsb pdb:6M5D|rcsb pdb:6M5E|rcsb pdb:6QIO|rcsb pdb:6QIP|rcsb pdb:6R7S|refseq:NP_000468.1|dip:DIP-29902N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:2DOjCrilHkv+l0r0zBQ1td2p+qc9606 rogid:kjtn5mBsCZz/NRkcyW5k3ZWeJBU9606 intact-crc:FB381AAB0D76A6D5|rigid:KPHYQSm84fUJVD5Rjp+mjvcVL5w false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H9J4 uniprotkb:Q92878 intact:EBI-2513638|uniprotkb:Q6P9B4|uniprotkb:Q3C166|uniprotkb:A2RUE3|uniprotkb:B5MDA5|uniprotkb:Q0VIN8 intact:EBI-495494|uniprotkb:O43254|uniprotkb:Q6GMT7|uniprotkb:Q6P5X3|uniprotkb:Q9UP86|uniprotkb:B9EGF5|ensembl:ENSP00000368100 psi-mi:ubp42_human(display_long)|uniprotkb:USP42(gene name)|psi-mi:USP42(display_short)|uniprotkb:Ubiquitin-specific-processing protease 42(gene name synonym)|uniprotkb:Deubiquitinating enzyme 42(gene name synonym)|uniprotkb:Ubiquitin thioesterase 42(gene name synonym) psi-mi:rad50_human(display_long)|uniprotkb:RAD50(gene name)|psi-mi:RAD50(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513636|imex:IM-12079-85 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007283"(spermatogenesis)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030154"(cell differentiation)|go:"GO:0042981"(regulation of apoptotic process)|reactome:R-HSA-5689880|interpro:IPR028889|interpro:IPR038765|refseq:NP_115548.1|interpro:IPR018200|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|mint:Q9H9J4 refseq:NP_005723.2|dip:DIP-33606N|ensembl:ENSG00000113522(gene)|ensembl:ENST00000378823(transcript)|go:"GO:0000019"(regulation of mitotic recombination)|go:"GO:0000722"(telomere maintenance via recombination)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0003677"(DNA binding)|go:"GO:0003691"(double-stranded telomeric DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0016020"(membrane)|go:"GO:0016787"(hydrolase activity)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030870"(Mre11 complex)|go:"GO:0031860"(telomeric 3' overhang formation)|go:"GO:0031954"(positive regulation of protein autophosphorylation)|go:"GO:0032206"(positive regulation of telomere maintenance)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042802"(identical protein binding)|go:"GO:0043047"(single-stranded telomeric DNA binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051880"(G-quadruplex DNA binding)|go:"GO:0070192"(chromosome organization involved in meiotic cell cycle)|go:"GO:0090305"(nucleic acid phosphodiester bond hydrolysis)|go:"GO:1904354"(negative regulation of telomere capping)|interpro:IPR013134(Zinc hook, Rad50)|interpro:IPR027417|interpro:IPR038729|mint:Q92878|rcsb pdb:5GOX|reactome:R-HSA-2559586|reactome:R-HSA-5685938|reactome:R-HSA-5685939|reactome:R-HSA-5685942|reactome:R-HSA-5693548|reactome:R-HSA-5693554|reactome:R-HSA-5693565|reactome:R-HSA-5693568|reactome:R-HSA-5693571|reactome:R-HSA-5693579|reactome:R-HSA-5693607|reactome:R-HSA-5693616|reactome:R-HSA-6804756|reactome:R-HSA-69473|reactome:R-HSA-912446|interpro:IPR004584(Recombination/repair protein Rad50) psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:kcGXFKKr/9BwysWkDkqi2iUmTCg9606 rogid:yZsT5GcpA9HeFMoK4Jb1HYhrdKQ9606 intact-crc:4E2159AB3827EA15|rigid:g3ZxzXGqanLtXGntmlYvrLvUjac false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H9J4 uniprotkb:Q9BV38 intact:EBI-2513638|uniprotkb:Q6P9B4|uniprotkb:Q3C166|uniprotkb:A2RUE3|uniprotkb:B5MDA5|uniprotkb:Q0VIN8 intact:EBI-727429|uniprotkb:O60390|uniprotkb:Q9BWR2|intact:EBI-28969560|ensembl:ENSP00000476117 psi-mi:ubp42_human(display_long)|uniprotkb:USP42(gene name)|psi-mi:USP42(display_short)|uniprotkb:Ubiquitin-specific-processing protease 42(gene name synonym)|uniprotkb:Deubiquitinating enzyme 42(gene name synonym)|uniprotkb:Ubiquitin thioesterase 42(gene name synonym) psi-mi:wdr18_human(display_long)|uniprotkb:WDR18(gene name)|psi-mi:WDR18(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513636|imex:IM-12079-85 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007283"(spermatogenesis)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030154"(cell differentiation)|go:"GO:0042981"(regulation of apoptotic process)|reactome:R-HSA-5689880|interpro:IPR028889|interpro:IPR038765|refseq:NP_115548.1|interpro:IPR018200|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|mint:Q9H9J4 refseq:NP_077005.2|ensembl:ENSP00000476117|go:"GO:0097344"(Rix1 complex)|go:"GO:0120293"(dynein axonemal particle)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR026987|interpro:IPR036322|mint:Q9BV38|reactome:R-HSA-6791226|ensembl:ENSG00000065268(gene)|ensembl:ENST00000585809(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005656"(nuclear pre-replicative complex)|go:"GO:0005730"(nucleolus)|go:"GO:0006364"(rRNA processing)|go:"GO:0030174"(regulation of DNA-dependent DNA replication initiation) psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:kcGXFKKr/9BwysWkDkqi2iUmTCg9606 rogid:03RKz4c6MKJvOePaNrKeInnS6Lg9606 intact-crc:4E2159AB3827EA15|rigid:g3ZxzXGqanLtXGntmlYvrLvUjac false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H9J4 uniprotkb:Q9UNQ2 intact:EBI-2513638|uniprotkb:Q6P9B4|uniprotkb:Q3C166|uniprotkb:A2RUE3|uniprotkb:B5MDA5|uniprotkb:Q0VIN8 intact:EBI-395738|uniprotkb:O76025|uniprotkb:Q9BU77|uniprotkb:Q9UES1|ensembl:ENSP00000199320 psi-mi:ubp42_human(display_long)|uniprotkb:USP42(gene name)|psi-mi:USP42(display_short)|uniprotkb:Ubiquitin-specific-processing protease 42(gene name synonym)|uniprotkb:Deubiquitinating enzyme 42(gene name synonym)|uniprotkb:Ubiquitin thioesterase 42(gene name synonym) psi-mi:dim1_human(display_long)|uniprotkb:DIMT1L(gene name synonym)|uniprotkb:DIM1 dimethyladenosine transferase 1 homolog(gene name synonym)|uniprotkb:DIM1 dimethyladenosine transferase 1-like(gene name synonym)|uniprotkb:HUSSY-05(orf name)|uniprotkb:"Probable 18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase"(gene name synonym)|uniprotkb:Probable 18S rRNA dimethylase(gene name synonym)|uniprotkb:DIMT1(gene name)|psi-mi:DIMT1(display_short)|uniprotkb:"Probable S-adenosylmethionine-6-N',N'-adenosyl(rRNA) dimethyltransferase"(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513636|imex:IM-12079-85 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007283"(spermatogenesis)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030154"(cell differentiation)|go:"GO:0042981"(regulation of apoptotic process)|reactome:R-HSA-5689880|interpro:IPR028889|interpro:IPR038765|refseq:NP_115548.1|interpro:IPR018200|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|mint:Q9H9J4 refseq:NP_055288.1|ensembl:ENSG00000086189(gene)|ensembl:ENST00000199320(transcript)|go:"GO:0000179"("rRNA (adenine-N6,N6-)-dimethyltransferase activity")|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0031167"(rRNA methylation)|go:"GO:0052909"("18S rRNA (adenine(1779)-N(6)/adenine(1780)-N(6))-dimethyltransferase activity")|go:"GO:2000234"(positive regulation of rRNA processing)|interpro:IPR001737(Ribosomal RNA adenine methylase transferase)|interpro:IPR011530(rRNA adenine dimethylase)|interpro:IPR020596|interpro:IPR020598|interpro:IPR029063|mint:Q9UNQ2|rcsb pdb:1ZQ9|rcsb pdb:6W6C|rcsb pdb:6W6F|reactome:R-HSA-6790901|refseq:NP_001335005.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:kcGXFKKr/9BwysWkDkqi2iUmTCg9606 rogid:hx0FRrx+XTeoziOqfesiw4KL+wo9606 intact-crc:4E2159AB3827EA15|rigid:g3ZxzXGqanLtXGntmlYvrLvUjac false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H9J4 uniprotkb:Q4VCS5 intact:EBI-2513638|uniprotkb:Q6P9B4|uniprotkb:Q3C166|uniprotkb:A2RUE3|uniprotkb:B5MDA5|uniprotkb:Q0VIN8 intact:EBI-2511319|ensembl:ENSP00000361027|uniprotkb:Q504X5|uniprotkb:Q9UPT1|uniprotkb:Q9HD27 psi-mi:ubp42_human(display_long)|uniprotkb:USP42(gene name)|psi-mi:USP42(display_short)|uniprotkb:Ubiquitin-specific-processing protease 42(gene name synonym)|uniprotkb:Deubiquitinating enzyme 42(gene name synonym)|uniprotkb:Ubiquitin thioesterase 42(gene name synonym) psi-mi:amot_human(display_long)|uniprotkb:AMOT(gene name)|psi-mi:AMOT(display_short)|uniprotkb:KIAA1071(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513636|imex:IM-12079-85 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007283"(spermatogenesis)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030154"(cell differentiation)|go:"GO:0042981"(regulation of apoptotic process)|reactome:R-HSA-5689880|interpro:IPR028889|interpro:IPR038765|refseq:NP_115548.1|interpro:IPR018200|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|mint:Q9H9J4 ensembl:ENSG00000126016(gene)|ensembl:ENST00000371959(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0001725"(stress fiber)|go:"GO:0001726"(ruffle)|go:"GO:0003365"(establishment of cell polarity involved in ameboidal cell migration)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006935"(chemotaxis)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030054"(cell junction)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035329"(hippo signaling)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0040019"(positive regulation of embryonic development)|go:"GO:0042074"(cell migration involved in gastrulation)|go:"GO:0043116"(negative regulation of vascular permeability)|go:"GO:0043532"(angiostatin binding)|go:"GO:0043534"(blood vessel endothelial cell migration)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0051496"(positive regulation of stress fiber assembly)|interpro:IPR009114(Angiomotin)|interpro:IPR024646|mint:Q4VCS5|rcsb pdb:6JJX|reactome:R-HSA-2028269|refseq:XP_011529177.1|refseq:NP_001106962.1|refseq:NP_573572.1|refseq:XP_005262144.1|refseq:XP_005262147.1|refseq:XP_016884778.1|dip:DIP-53711N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:kcGXFKKr/9BwysWkDkqi2iUmTCg9606 rogid:5O9K+GgX1s0Hn5optTeKPOs+X1s9606 intact-crc:4E2159AB3827EA15|rigid:g3ZxzXGqanLtXGntmlYvrLvUjac false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H9J4 uniprotkb:Q9NXF1 intact:EBI-2513638|uniprotkb:Q6P9B4|uniprotkb:Q3C166|uniprotkb:A2RUE3|uniprotkb:B5MDA5|uniprotkb:Q0VIN8 intact:EBI-2371062|uniprotkb:Q5T722|uniprotkb:Q5T723|uniprotkb:Q8NCN8|uniprotkb:Q8TDY0|uniprotkb:B4DYV2|ensembl:ENSP00000364037 psi-mi:ubp42_human(display_long)|uniprotkb:USP42(gene name)|psi-mi:USP42(display_short)|uniprotkb:Ubiquitin-specific-processing protease 42(gene name synonym)|uniprotkb:Deubiquitinating enzyme 42(gene name synonym)|uniprotkb:Ubiquitin thioesterase 42(gene name synonym) psi-mi:tex10_human(display_long)|uniprotkb:TEX10(gene name)|psi-mi:TEX10(display_short)|uniprotkb:L18(orf name)|uniprotkb:Nbla10363(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513636|imex:IM-12079-85 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007283"(spermatogenesis)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030154"(cell differentiation)|go:"GO:0042981"(regulation of apoptotic process)|reactome:R-HSA-5689880|interpro:IPR028889|interpro:IPR038765|refseq:NP_115548.1|interpro:IPR018200|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|mint:Q9H9J4 refseq:NP_060216.2|refseq:NP_001155056.1|ensembl:ENSG00000136891(gene)|ensembl:ENST00000374902(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005739"(mitochondrion)|go:"GO:0071339"(MLL1 complex)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR021133|interpro:IPR024679|interpro:IPR037947|mint:Q9NXF1|reactome:R-HSA-6791226 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:kcGXFKKr/9BwysWkDkqi2iUmTCg9606 rogid:cQcRo1eExRkr/an7wvBN8Ttyatc9606 intact-crc:4E2159AB3827EA15|rigid:g3ZxzXGqanLtXGntmlYvrLvUjac false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H9J4 uniprotkb:Q14692 intact:EBI-2513638|uniprotkb:Q6P9B4|uniprotkb:Q3C166|uniprotkb:A2RUE3|uniprotkb:B5MDA5|uniprotkb:Q0VIN8 intact:EBI-2513630|ensembl:ENSP00000363642|uniprotkb:Q86XJ9|uniprotkb:Q5QPT5 psi-mi:ubp42_human(display_long)|uniprotkb:USP42(gene name)|psi-mi:USP42(display_short)|uniprotkb:Ubiquitin-specific-processing protease 42(gene name synonym)|uniprotkb:Deubiquitinating enzyme 42(gene name synonym)|uniprotkb:Ubiquitin thioesterase 42(gene name synonym) psi-mi:bms1_human(display_long)|uniprotkb:BMS1(gene name)|psi-mi:BMS1(display_short)|uniprotkb:BMS1L(gene name synonym)|uniprotkb:KIAA0187(gene name synonym)|uniprotkb:Ribosome assembly protein BMS1 homolog(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513636|imex:IM-12079-85 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007283"(spermatogenesis)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030154"(cell differentiation)|go:"GO:0042981"(regulation of apoptotic process)|reactome:R-HSA-5689880|interpro:IPR028889|interpro:IPR038765|refseq:NP_115548.1|interpro:IPR018200|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|mint:Q9H9J4 ensembl:ENSG00000165733(gene)|ensembl:ENST00000374518(transcript)|go:"GO:0000462"("maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0000479"("endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0003723"(RNA binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0030686"(90S preribosome)|go:"GO:0034511"(U3 snoRNA binding)|interpro:IPR007034(Protein of unknown function DUF663)|interpro:IPR012948(AARP2CN)|interpro:IPR027417|interpro:IPR030387|interpro:IPR037875|interpro:IPR039761|mint:Q14692|reactome:R-HSA-6790901|reactome:R-HSA-6791226|go:"GO:0005730"(nucleolus)|refseq:XP_011538704.1|refseq:NP_055568.3|refseq:XP_005271903.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:kcGXFKKr/9BwysWkDkqi2iUmTCg9606 rogid:9sd7sK6/Ue4DgLRT+j9Iw0+8om09606 intact-crc:4E2159AB3827EA15|rigid:g3ZxzXGqanLtXGntmlYvrLvUjac false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H9J4 uniprotkb:O75131 intact:EBI-2513638|uniprotkb:Q6P9B4|uniprotkb:Q3C166|uniprotkb:A2RUE3|uniprotkb:B5MDA5|uniprotkb:Q0VIN8 intact:EBI-718988|uniprotkb:Q8IYA1|uniprotkb:A8KA47|ensembl:ENSP00000477590 psi-mi:ubp42_human(display_long)|uniprotkb:USP42(gene name)|psi-mi:USP42(display_short)|uniprotkb:Ubiquitin-specific-processing protease 42(gene name synonym)|uniprotkb:Deubiquitinating enzyme 42(gene name synonym)|uniprotkb:Ubiquitin thioesterase 42(gene name synonym) psi-mi:cpne3_human(display_long)|uniprotkb:Copine III(gene name synonym)|uniprotkb:CPNE3(gene name)|psi-mi:CPNE3(display_short)|uniprotkb:CPN3(gene name synonym)|uniprotkb:KIAA0636(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513636|imex:IM-12079-85 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007283"(spermatogenesis)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030154"(cell differentiation)|go:"GO:0042981"(regulation of apoptotic process)|reactome:R-HSA-5689880|interpro:IPR028889|interpro:IPR038765|refseq:NP_115548.1|interpro:IPR018200|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|mint:Q9H9J4 refseq:NP_003900.1|refseq:XP_005251150.1|ensembl:ENSG00000085719(gene)|ensembl:ENST00000517490(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005544"(calcium-dependent phospholipid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0030054"(cell junction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0038128"(ERBB2 signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071363"(cellular response to growth factor stimulus)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR010734(Copine)|interpro:IPR035892|interpro:IPR036465|interpro:IPR037768|mint:O75131|reactome:R-HSA-1483206|reactome:R-HSA-6798695|refseq:XP_016869434.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:kcGXFKKr/9BwysWkDkqi2iUmTCg9606 rogid:75lb/sKHpJYCwCLIq973pzNMfzw9606 intact-crc:4E2159AB3827EA15|rigid:g3ZxzXGqanLtXGntmlYvrLvUjac false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H9J4 uniprotkb:Q8N1G4 intact:EBI-2513638|uniprotkb:Q6P9B4|uniprotkb:Q3C166|uniprotkb:A2RUE3|uniprotkb:B5MDA5|uniprotkb:Q0VIN8 intact:EBI-2509921|ensembl:ENSP00000367498|uniprotkb:Q9ULN5 psi-mi:ubp42_human(display_long)|uniprotkb:USP42(gene name)|psi-mi:USP42(display_short)|uniprotkb:Ubiquitin-specific-processing protease 42(gene name synonym)|uniprotkb:Deubiquitinating enzyme 42(gene name synonym)|uniprotkb:Ubiquitin thioesterase 42(gene name synonym) psi-mi:lrc47_human(display_long)|uniprotkb:LRRC47(gene name)|psi-mi:LRRC47(display_short)|uniprotkb:KIAA1185(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513636|imex:IM-12079-85 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007283"(spermatogenesis)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030154"(cell differentiation)|go:"GO:0042981"(regulation of apoptotic process)|reactome:R-HSA-5689880|interpro:IPR028889|interpro:IPR038765|refseq:NP_115548.1|interpro:IPR018200|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|mint:Q9H9J4 ensembl:ENSG00000130764(gene)|ensembl:ENST00000378251(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004826"(phenylalanine-tRNA ligase activity)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR005146(B3/B4 tRNA-binding domain)|interpro:IPR020825|interpro:IPR025875|interpro:IPR032675|rcsb pdb:6ZXD|rcsb pdb:6ZXE|rcsb pdb:6ZXF|rcsb pdb:6ZXG|refseq:NP_065761.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:kcGXFKKr/9BwysWkDkqi2iUmTCg9606 rogid:aPzU//EIwK8J4it97jCw/YyKFWU9606 intact-crc:4E2159AB3827EA15|rigid:g3ZxzXGqanLtXGntmlYvrLvUjac false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H9J4 uniprotkb:Q9BYN8 intact:EBI-2513638|uniprotkb:Q6P9B4|uniprotkb:Q3C166|uniprotkb:A2RUE3|uniprotkb:B5MDA5|uniprotkb:Q0VIN8 intact:EBI-721378|uniprotkb:Q96Q58|ensembl:ENSP00000369682 psi-mi:ubp42_human(display_long)|uniprotkb:USP42(gene name)|psi-mi:USP42(display_short)|uniprotkb:Ubiquitin-specific-processing protease 42(gene name synonym)|uniprotkb:Deubiquitinating enzyme 42(gene name synonym)|uniprotkb:Ubiquitin thioesterase 42(gene name synonym) psi-mi:rt26_human(display_long)|uniprotkb:28S ribosomal protein S13, mitochondrial(gene name synonym)|uniprotkb:MRPS26(gene name)|psi-mi:MRPS26(display_short)|uniprotkb:RPMS13(gene name synonym)|uniprotkb:C20orf193(gene name synonym)|uniprotkb:Mitochondrial small ribosomal subunit protein mS26(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513636|imex:IM-12079-85 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007283"(spermatogenesis)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030154"(cell differentiation)|go:"GO:0042981"(regulation of apoptotic process)|reactome:R-HSA-5689880|interpro:IPR028889|interpro:IPR038765|refseq:NP_115548.1|interpro:IPR018200|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|mint:Q9H9J4 refseq:NP_110438.1|rcsb pdb:3J9M|rcsb pdb:6NU2|rcsb pdb:6NU3|rcsb pdb:6RW4|rcsb pdb:6RW5|rcsb pdb:6VLZ|rcsb pdb:6VMI|rcsb pdb:6ZM5|rcsb pdb:6ZM6|rcsb pdb:6ZS9|rcsb pdb:6ZSA|rcsb pdb:6ZSB|rcsb pdb:6ZSC|rcsb pdb:6ZSD|rcsb pdb:6ZSE|rcsb pdb:6ZSG|rcsb pdb:7A5F|rcsb pdb:7A5G|rcsb pdb:7A5I|rcsb pdb:7A5K|rcsb pdb:7L08|rcsb pdb:7OG4|reactome:R-HSA-5368286|reactome:R-HSA-5389840|reactome:R-HSA-5419276|ensembl:ENSG00000125901(gene)|ensembl:ENST00000380325(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005763"(mitochondrial small ribosomal subunit)|go:"GO:0042769"(obsolete DNA damage response, detection of DNA damage)|interpro:IPR026140|mint:Q9BYN8 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:kcGXFKKr/9BwysWkDkqi2iUmTCg9606 rogid:ZygMazfhjHbx+aFhRkeG87c4L6E9606 intact-crc:4E2159AB3827EA15|rigid:g3ZxzXGqanLtXGntmlYvrLvUjac false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H9J4 uniprotkb:P00918 intact:EBI-2513638|uniprotkb:Q6P9B4|uniprotkb:Q3C166|uniprotkb:A2RUE3|uniprotkb:B5MDA5|uniprotkb:Q0VIN8 intact:EBI-724062|ensembl:ENSP00000285379|uniprotkb:Q6FI12|uniprotkb:Q96ET9|uniprotkb:B2R7G8 psi-mi:ubp42_human(display_long)|uniprotkb:USP42(gene name)|psi-mi:USP42(display_short)|uniprotkb:Ubiquitin-specific-processing protease 42(gene name synonym)|uniprotkb:Deubiquitinating enzyme 42(gene name synonym)|uniprotkb:Ubiquitin thioesterase 42(gene name synonym) psi-mi:cah2_human(display_long)|uniprotkb:Carbonic anhydrase II(gene name synonym)|uniprotkb:Carbonate dehydratase II(gene name synonym)|uniprotkb:Carbonic anhydrase C(gene name synonym)|uniprotkb:CA2(gene name)|psi-mi:CA2(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513636|imex:IM-12079-85 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007283"(spermatogenesis)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030154"(cell differentiation)|go:"GO:0042981"(regulation of apoptotic process)|reactome:R-HSA-5689880|interpro:IPR028889|interpro:IPR038765|refseq:NP_115548.1|interpro:IPR018200|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|mint:Q9H9J4 refseq:NP_000058.1|rcsb pdb:5YUI|rcsb pdb:5YUJ|rcsb pdb:5U0G|rcsb pdb:5YUK|rcsb pdb:5ZXW|rcsb pdb:6B4D|rcsb pdb:6B59|rcsb pdb:5ULN|rcsb pdb:6B5A|rcsb pdb:6BBS|rcsb pdb:6BC9|rcsb pdb:6BCC|rcsb pdb:6C7W|rcsb pdb:6C7X|rcsb pdb:6CA2|rcsb pdb:6CEH|rcsb pdb:6CJV|rcsb pdb:6D1L|rcsb pdb:6D1M|rcsb pdb:5UMC|rcsb pdb:5VGY|rcsb pdb:6E8P|rcsb pdb:6E8X|rcsb pdb:6E91|rcsb pdb:6E92|rcsb pdb:6EBE|rcsb pdb:6ECZ|rcsb pdb:6EDA|rcsb pdb:6EEA|rcsb pdb:6EEH|rcsb pdb:6EEO|rcsb pdb:6EQU|rcsb pdb:5W8B|rcsb pdb:6FJI|rcsb pdb:5WEX|rcsb pdb:6FJJ|rcsb pdb:6G3Q|rcsb pdb:6G6T|rcsb pdb:6GCY|rcsb pdb:6GDC|rcsb pdb:6GM9|rcsb pdb:5WG7|rcsb pdb:5WGP|rcsb pdb:5WLR|rcsb pdb:6GOT|rcsb pdb:6GXB|rcsb pdb:5WLT|rcsb pdb:5WLU|rcsb pdb:5WLV|rcsb pdb:5Y2R|rcsb pdb:5Y2S|rcsb pdb:6GXE|rcsb pdb:6H29|rcsb pdb:6H2Z|rcsb pdb:6H33|rcsb pdb:6H34|rcsb pdb:6H3Q|rcsb pdb:6H6S|rcsb pdb:6HD2|rcsb pdb:1BV3|rcsb pdb:1CA2|rcsb pdb:1CA3|rcsb pdb:1CAH|rcsb pdb:1CAI|rcsb pdb:1CAJ|rcsb pdb:1CAK|rcsb pdb:1CAL|rcsb pdb:1CAM|rcsb pdb:1CAN|rcsb pdb:1CAO|rcsb pdb:1CAY|rcsb pdb:1CAZ|rcsb pdb:1CCS|rcsb pdb:1CCT|rcsb pdb:1CCU|rcsb pdb:1CIL|rcsb pdb:1CIM|rcsb pdb:1CIN|rcsb pdb:1CNB|rcsb pdb:1CNC|rcsb pdb:1CNG|rcsb pdb:1CNH|rcsb pdb:1CNI|rcsb pdb:1CNJ|rcsb pdb:1BNW|rcsb pdb:1CNK|rcsb pdb:1CNW|rcsb pdb:1CNX|rcsb pdb:1CNY|rcsb pdb:1CRA|rcsb pdb:1CVA|rcsb pdb:1CVB|rcsb pdb:1IF4|rcsb pdb:1IF5|rcsb pdb:1IF6|rcsb pdb:1IF7|rcsb pdb:1IF8|rcsb pdb:1IF9|rcsb pdb:1KWQ|rcsb pdb:1I9Q|rcsb pdb:1KWR|rcsb pdb:1LG5|rcsb pdb:1LG6|rcsb pdb:1LGD|rcsb pdb:1LUG|rcsb pdb:1LZV|rcsb pdb:1MOO|rcsb pdb:1MUA|rcsb pdb:1OKL|rcsb pdb:1OKM|rcsb pdb:1OKN|rcsb pdb:1OQ5|rcsb pdb:1RAY|rcsb pdb:1RAZ|rcsb pdb:1RZA|rcsb pdb:1RZB|rcsb pdb:1RZC|rcsb pdb:1RZD|rcsb pdb:1RZE|rcsb pdb:1T9N|rcsb pdb:1TB0|rcsb pdb:1TBT|rcsb pdb:1TE3|rcsb pdb:1TEQ|rcsb pdb:1TEU|rcsb pdb:6HR3|rcsb pdb:6HX5|rcsb pdb:6HXD|rcsb pdb:6HZX|rcsb pdb:6I0W|rcsb pdb:6I1U|rcsb pdb:6I2F|rcsb pdb:6I3E|rcsb pdb:6IC2|rcsb pdb:6KLZ|rcsb pdb:6KM0|rcsb pdb:6KM1|rcsb pdb:6KM2|rcsb pdb:6KM3|rcsb pdb:6KM4|rcsb pdb:6KM5|rcsb pdb:6KM6|rcsb pdb:6LUU|rcsb pdb:6LUV|rcsb pdb:6LUW|rcsb pdb:6LUX|rcsb pdb:6LUY|rcsb pdb:6LUZ|rcsb pdb:6LV1|rcsb pdb:6LV2|rcsb pdb:6LV3|rcsb pdb:6LV4|rcsb pdb:6LV5|rcsb pdb:6LV6|rcsb pdb:6LV7|rcsb pdb:6LV8|rcsb pdb:6LV9|rcsb pdb:6HQX|rcsb pdb:6LVA|rcsb pdb:6MBV|rcsb pdb:6MBY|rcsb pdb:6NLV|rcsb pdb:6NM0|rcsb pdb:6ODZ|rcsb pdb:6OE0|rcsb pdb:6OE1|rcsb pdb:6OTI|rcsb pdb:6OTK|rcsb pdb:6OTM|rcsb pdb:6OTO|rcsb pdb:6OTP|rcsb pdb:6OTQ|rcsb pdb:1CVC|rcsb pdb:1CVD|rcsb pdb:1CVE|rcsb pdb:1G46|rcsb pdb:1G48|rcsb pdb:1CVF|rcsb pdb:1CVH|rcsb pdb:1DCA|rcsb pdb:1DCB|rcsb pdb:1EOU|rcsb pdb:1F2W|rcsb pdb:1FQL|rcsb pdb:1FQM|rcsb pdb:1FQN|rcsb pdb:1FQR|rcsb pdb:1FR4|rcsb pdb:1FR7|rcsb pdb:1FSN|rcsb pdb:1FSQ|rcsb pdb:1FSR|rcsb pdb:1G0E|rcsb pdb:1G0F|rcsb pdb:1G1D|rcsb pdb:1G3Z|rcsb pdb:1G45|rcsb pdb:6OUD|rcsb pdb:6OUE|rcsb pdb:6OUF|rcsb pdb:6OUH|rcsb pdb:6OUI|rcsb pdb:6OUJ|rcsb pdb:6OUK|rcsb pdb:6OUM|rcsb pdb:6PDV|rcsb pdb:6PEA|rcsb pdb:6PGX|rcsb pdb:6Q3O|rcsb pdb:6Q9T|rcsb pdb:6QEB|rcsb pdb:6QL1|rcsb pdb:6QL2|rcsb pdb:6QL3|rcsb pdb:6OUB|rcsb pdb:6R6F|rcsb pdb:6R6J|rcsb pdb:6RFH|rcsb pdb:6RG3|rcsb pdb:6RG4|rcsb pdb:6RG5|rcsb pdb:6RH4|rcsb pdb:6RHJ|rcsb pdb:6RHK|rcsb pdb:6RIG|rcsb pdb:6RIT|rcsb pdb:6RJJ|rcsb pdb:6RKN|rcsb pdb:6RL9|rcsb pdb:6RM1|rcsb pdb:6RMP|rcsb pdb:6RMX|rcsb pdb:6RMY|rcsb pdb:6RNP|rcsb pdb:6ROB|rcsb pdb:6ROE|rcsb pdb:6ROF|rcsb pdb:3TVO|rcsb pdb:3U3A|rcsb pdb:3U45|rcsb pdb:3U47|rcsb pdb:3U7C|rcsb pdb:3V2J|rcsb pdb:3TVN|rcsb pdb:3V2M|rcsb pdb:3V3F|rcsb pdb:3V3G|rcsb pdb:3V3H|rcsb pdb:3V3I|rcsb pdb:3V3J|rcsb pdb:3V5G|rcsb pdb:3V7X|rcsb pdb:3VBD|rcsb pdb:3ZP9|rcsb pdb:4BCW|rcsb pdb:4BF1|rcsb pdb:4BF6|rcsb pdb:4CA2|rcsb pdb:4CAC|rcsb pdb:4CQ0|rcsb pdb:4DZ7|rcsb pdb:4DZ9|rcsb pdb:4E3D|rcsb pdb:6RQI|rcsb pdb:6T5C|rcsb pdb:6T7U|rcsb pdb:6T81|rcsb pdb:6T9Z|rcsb pdb:6U4Q|rcsb pdb:6U4T|rcsb pdb:6UFB|rcsb pdb:6UFC|rcsb pdb:6UFD|rcsb pdb:6UGN|rcsb pdb:6UGO|rcsb pdb:6UGP|rcsb pdb:6UGQ|rcsb pdb:6UGR|rcsb pdb:6UGZ|rcsb pdb:6UH0|rcsb pdb:6UX1|rcsb pdb:6UZU|rcsb pdb:6VJ3|rcsb pdb:6VKG|rcsb pdb:1TG3|rcsb pdb:1TG9|rcsb pdb:1TH9|rcsb pdb:1THK|rcsb pdb:1TTM|rcsb pdb:1UGA|rcsb pdb:1UGB|rcsb pdb:1UGC|rcsb pdb:1UGD|rcsb pdb:1UGE|rcsb pdb:1UGF|rcsb pdb:1UGG|rcsb pdb:1XEG|rcsb pdb:1XEV|rcsb pdb:1XPZ|rcsb pdb:1XQ0|rcsb pdb:1YDA|rcsb pdb:1YDB|rcsb pdb:1YDC|rcsb pdb:1YDD|rcsb pdb:1YO0|rcsb pdb:1YO1|rcsb pdb:1YO2|rcsb pdb:1Z9Y|rcsb pdb:1ZE8|rcsb pdb:1ZFK|rcsb pdb:1ZFQ|rcsb pdb:1ZGE|rcsb pdb:4E3F|rcsb pdb:4E3G|rcsb pdb:4E3H|rcsb pdb:4E49|rcsb pdb:4E4A|rcsb pdb:4E5Q|rcsb pdb:4FIK|rcsb pdb:4FL7|rcsb pdb:4FPT|rcsb pdb:4FRC|rcsb pdb:4FU5|rcsb pdb:4FVN|rcsb pdb:4FVO|rcsb pdb:4G0C|rcsb pdb:4GL1|rcsb pdb:4HBA|rcsb pdb:4HEW|rcsb pdb:4HEY|rcsb pdb:4HEZ|rcsb pdb:4HF3|rcsb pdb:4HT0|rcsb pdb:4IDR|rcsb pdb:4ILX|rcsb pdb:4ITO|rcsb pdb:4ITP|rcsb pdb:4IWZ|rcsb pdb:4JS6|rcsb pdb:4JSA|rcsb pdb:4JSS|rcsb pdb:4JSW|rcsb pdb:4JSZ|rcsb pdb:4K0S|rcsb pdb:4K0T|rcsb pdb:4K0Z|rcsb pdb:4K13|rcsb pdb:4K1Q|rcsb pdb:4KAP|rcsb pdb:4KNI|rcsb pdb:4KNJ|rcsb pdb:4KUV|rcsb pdb:4KUW|rcsb pdb:4KUY|rcsb pdb:4KV0|rcsb pdb:4L5U|rcsb pdb:4L5V|rcsb pdb:4L5W|rcsb pdb:4LHI|rcsb pdb:4LP6|rcsb pdb:4M2R|rcsb pdb:4M2U|rcsb pdb:4M2V|rcsb pdb:4M2W|rcsb pdb:4MDG|rcsb pdb:4MDL|rcsb pdb:4MDM|rcsb pdb:4MLT|rcsb pdb:4MLX|rcsb pdb:1ZGF|rcsb pdb:1ZH9|rcsb pdb:1ZSA|rcsb pdb:1ZSB|rcsb pdb:1ZSC|rcsb pdb:2ABE|rcsb pdb:2AW1|rcsb pdb:2AX2|rcsb pdb:2CA2|rcsb pdb:2CBA|rcsb pdb:2CBB|rcsb pdb:2CBC|rcsb pdb:2CBD|rcsb pdb:2CBE|rcsb pdb:2EU2|rcsb pdb:2EU3|rcsb pdb:2EZ7|rcsb pdb:2F14|rcsb pdb:2FMG|rcsb pdb:2FMZ|rcsb pdb:2FNK|rcsb pdb:2FNM|rcsb pdb:2FNN|rcsb pdb:2HOC|rcsb pdb:2FOQ|rcsb pdb:2FOS|rcsb pdb:2ILI|rcsb pdb:2FOU|rcsb pdb:2NNG|rcsb pdb:2NNO|rcsb pdb:2NNS|rcsb pdb:2FOV|rcsb pdb:2GD8|rcsb pdb:2GEH|rcsb pdb:2NNV|rcsb pdb:2NWO|rcsb pdb:2NWP|rcsb pdb:2NWY|rcsb pdb:2NWZ|rcsb pdb:2H15|rcsb pdb:2NXR|rcsb pdb:2NXS|rcsb pdb:2NXT|rcsb pdb:2O4Z|rcsb pdb:2OSF|rcsb pdb:2OSM|rcsb pdb:2POU|rcsb pdb:2POV|rcsb pdb:2POW|rcsb pdb:2H4N|rcsb pdb:2Q1B|rcsb pdb:2Q1Q|rcsb pdb:2Q38|rcsb pdb:2QO8|rcsb pdb:2QOA|rcsb pdb:2QP6|rcsb pdb:2VVA|rcsb pdb:2VVB|rcsb pdb:2HD6|rcsb pdb:2HKK|rcsb pdb:2WD2|rcsb pdb:2WD3|rcsb pdb:2HL4|rcsb pdb:2HNC|rcsb pdb:2WEG|rcsb pdb:2WEH|rcsb pdb:2WEJ|rcsb pdb:2WEO|rcsb pdb:4MTY|rcsb pdb:4N0X|rcsb pdb:4N16|rcsb pdb:4PQ7|rcsb pdb:4PXX|rcsb pdb:4PYX|rcsb pdb:4PYY|rcsb pdb:4PZH|rcsb pdb:4Q06|rcsb pdb:4Q07|rcsb pdb:4Q08|rcsb pdb:4Q09|rcsb pdb:4Q49|rcsb pdb:4Q6D|rcsb pdb:4Q6E|rcsb pdb:4Q78|rcsb pdb:4Q7P|rcsb pdb:4Q7S|rcsb pdb:4Q7V|rcsb pdb:4Q7W|rcsb pdb:4Q81|rcsb pdb:4Q83|rcsb pdb:4Q87|rcsb pdb:4Q8X|rcsb pdb:4Q8Y|rcsb pdb:4Q8Z|rcsb pdb:4Q90|rcsb pdb:4Q99|rcsb pdb:4Q9Y|rcsb pdb:4QEF|rcsb pdb:4QIY|rcsb pdb:4QJM|rcsb pdb:4QK1|rcsb pdb:4QK2|rcsb pdb:4QK3|rcsb pdb:4QSA|rcsb pdb:4QSB|rcsb pdb:4QSI|rcsb pdb:4QTL|rcsb pdb:4QY3|rcsb pdb:4R59|rcsb pdb:4R5A|rcsb pdb:4R5B|rcsb pdb:4RFC|rcsb pdb:4RFD|rcsb pdb:4RH2|rcsb pdb:4RIU|rcsb pdb:4RIV|rcsb pdb:4RN4|rcsb pdb:4RUX|rcsb pdb:4RUY|rcsb pdb:4RUZ|rcsb pdb:4WL4|rcsb pdb:4WW6|rcsb pdb:4MO8|rcsb pdb:4XE1|rcsb pdb:4Y0J|rcsb pdb:4YGJ|rcsb pdb:4YGK|rcsb pdb:4YGL|rcsb pdb:4YGN|rcsb pdb:4YVY|rcsb pdb:4YWP|rcsb pdb:4YX4|rcsb pdb:4YXI|rcsb pdb:4YXO|rcsb pdb:6RRI|rcsb pdb:6RS5|rcsb pdb:6RSZ|rcsb pdb:6RVF|rcsb pdb:6RVK|rcsb pdb:6RVL|rcsb pdb:6RW1|rcsb pdb:6RZX|rcsb pdb:6S03|rcsb pdb:6S9G|rcsb pdb:6S9Z|rcsb pdb:6SAC|rcsb pdb:6SAS|rcsb pdb:6SAY|rcsb pdb:6SB7|rcsb pdb:6SBH|rcsb pdb:6SBL|rcsb pdb:6SBM|rcsb pdb:6SD7|rcsb pdb:6SDH|rcsb pdb:6SDI|rcsb pdb:6SDJ|rcsb pdb:6SDL|rcsb pdb:6SDS|rcsb pdb:6SEY|rcsb pdb:6RRG|rcsb pdb:6SFQ|rcsb pdb:6SFU|rcsb pdb:6SG0|rcsb pdb:6SG6|rcsb pdb:6SX9|rcsb pdb:6SYB|rcsb pdb:6SYS|rcsb pdb:6T4N|rcsb pdb:6T4O|rcsb pdb:6T4P|rcsb pdb:2X7S|rcsb pdb:2X7T|rcsb pdb:2X7U|rcsb pdb:3B4F|rcsb pdb:3BET|rcsb pdb:3BL0|rcsb pdb:3BL1|rcsb pdb:3C7P|rcsb pdb:3CA2|rcsb pdb:3CAJ|rcsb pdb:3CYU|rcsb pdb:3D8W|rcsb pdb:3D92|rcsb pdb:3D93|rcsb pdb:3D9Z|rcsb pdb:3DAZ|rcsb pdb:3DBU|rcsb pdb:3DC3|rcsb pdb:3DC9|rcsb pdb:3DCC|rcsb pdb:3DCS|rcsb pdb:3DCW|rcsb pdb:3DD0|rcsb pdb:3DD8|rcsb pdb:3DV7|rcsb pdb:3DVB|rcsb pdb:3DVC|rcsb pdb:3DVD|rcsb pdb:3EFI|rcsb pdb:3EFT|rcsb pdb:4YYT|rcsb pdb:4Z0Q|rcsb pdb:4Z1E|rcsb pdb:4Z1J|rcsb pdb:4Z1K|rcsb pdb:4Z1N|rcsb pdb:4ZAO|rcsb pdb:4ZWI|rcsb pdb:4ZWX|rcsb pdb:4ZWY|rcsb pdb:4ZWZ|rcsb pdb:4ZX0|rcsb pdb:4ZX1|rcsb pdb:5A6H|rcsb pdb:5AMD|rcsb pdb:5AMG|rcsb pdb:5AML|rcsb pdb:5BNL|rcsb pdb:5BRU|rcsb pdb:5BRV|rcsb pdb:5BRW|rcsb pdb:5BYI|rcsb pdb:5C8I|rcsb pdb:5CA2|rcsb pdb:5CAC|rcsb pdb:5CLU|rcsb pdb:5DOG|rcsb pdb:5DOH|rcsb pdb:5DRS|rcsb pdb:5DSK|rcsb pdb:5DSL|rcsb pdb:5DSM|rcsb pdb:5DSO|rcsb pdb:5DSP|rcsb pdb:4YXU|rcsb pdb:5DSQ|rcsb pdb:5DSR|rcsb pdb:5E28|rcsb pdb:5E2K|rcsb pdb:5E2R|rcsb pdb:5E2S|rcsb pdb:5EH5|rcsb pdb:5EH7|rcsb pdb:5EH8|rcsb pdb:5EHE|rcsb pdb:5EHV|rcsb pdb:5EHW|rcsb pdb:5EIJ|rcsb pdb:5EKH|rcsb pdb:3F4X|rcsb pdb:3F8E|rcsb pdb:3FFP|rcsb pdb:3GZ0|rcsb pdb:3HFP|rcsb pdb:3HKN|rcsb pdb:3HKQ|rcsb pdb:3HKT|rcsb pdb:3HKU|rcsb pdb:3HLJ|rcsb pdb:3HS4|rcsb pdb:3IBI|rcsb pdb:3IBL|rcsb pdb:3IBN|rcsb pdb:3IBU|rcsb pdb:3IEO|rcsb pdb:3IGP|rcsb pdb:3K2F|rcsb pdb:3K34|rcsb pdb:3K7K|rcsb pdb:3KIG|rcsb pdb:3KKX|rcsb pdb:3KNE|rcsb pdb:3KOI|rcsb pdb:3KOK|rcsb pdb:3KON|rcsb pdb:3KS3|rcsb pdb:3KWA|rcsb pdb:3L14|rcsb pdb:3M04|rcsb pdb:3M14|rcsb pdb:3M1J|rcsb pdb:3M1K|rcsb pdb:3M1Q|rcsb pdb:3M1W|rcsb pdb:3M2N|rcsb pdb:3M2X|rcsb pdb:3M2Y|rcsb pdb:3M2Z|rcsb pdb:3M3X|rcsb pdb:3M40|rcsb pdb:3M5E|rcsb pdb:3M5S|rcsb pdb:3M5T|rcsb pdb:3M67|rcsb pdb:3M96|rcsb pdb:3M98|rcsb pdb:3MHC|rcsb pdb:3MHI|rcsb pdb:3MHL|rcsb pdb:3MHM|rcsb pdb:3MHO|rcsb pdb:3ML2|rcsb pdb:3MMF|rcsb pdb:3MNA|rcsb pdb:3MNH|rcsb pdb:3MNI|rcsb pdb:3MNJ|rcsb pdb:3MNK|rcsb pdb:3MNU|rcsb pdb:3MWO|rcsb pdb:3MYQ|rcsb pdb:3MZC|rcsb pdb:3N0N|rcsb pdb:3N2P|rcsb pdb:5EKM|rcsb pdb:5EOI|rcsb pdb:5FDC|rcsb pdb:5FDI|rcsb pdb:5FLO|rcsb pdb:5FLP|rcsb pdb:5FLQ|rcsb pdb:5FLR|rcsb pdb:5FLS|rcsb pdb:5FLT|rcsb pdb:5FNG|rcsb pdb:5FNH|rcsb pdb:5FNI|rcsb pdb:5FNJ|rcsb pdb:5FNK|rcsb pdb:5FNL|rcsb pdb:5FNM|rcsb pdb:5G01|rcsb pdb:5G03|rcsb pdb:5G0B|rcsb pdb:5G0C|rcsb pdb:5GMN|rcsb pdb:5J8Z|rcsb pdb:5EKJ|rcsb pdb:3N4B|rcsb pdb:3N3J|rcsb pdb:3NB5|rcsb pdb:3NI5|rcsb pdb:3NJ9|rcsb pdb:3OIK|rcsb pdb:3OIL|rcsb pdb:3OIM|rcsb pdb:3OKU|rcsb pdb:3OKV|rcsb pdb:3OY0|rcsb pdb:3OYQ|rcsb pdb:3OYS|rcsb pdb:3P3H|rcsb pdb:3P3J|rcsb pdb:3P44|rcsb pdb:3P4V|rcsb pdb:3P55|rcsb pdb:3P58|rcsb pdb:3P5A|rcsb pdb:3P5L|rcsb pdb:3PJJ|rcsb pdb:3PO6|rcsb pdb:5JE7|rcsb pdb:5JEG|rcsb pdb:5JEH|rcsb pdb:5JEP|rcsb pdb:5JES|rcsb pdb:5JG3|rcsb pdb:5JG5|rcsb pdb:5JGS|rcsb pdb:5JGT|rcsb pdb:5JMZ|rcsb pdb:5JN3|rcsb pdb:5JN7|rcsb pdb:5JQ0|rcsb pdb:5JQT|rcsb pdb:5L3O|rcsb pdb:5L6K|rcsb pdb:5L6T|rcsb pdb:5L70|rcsb pdb:5L9E|rcsb pdb:5JDV|rcsb pdb:5LJQ|rcsb pdb:5LJT|rcsb pdb:5LL4|rcsb pdb:5LL8|rcsb pdb:5LLC|rcsb pdb:5LLE|rcsb pdb:5LLG|rcsb pdb:5LLH|rcsb pdb:5LMD|rcsb pdb:5LVS|rcsb pdb:5M78|rcsb pdb:5MJN|rcsb pdb:5N0D|rcsb pdb:5N0E|rcsb pdb:5N1R|rcsb pdb:5N1S|rcsb pdb:5N24|rcsb pdb:5N25|rcsb pdb:5NEA|rcsb pdb:5NEE|rcsb pdb:5NXG|ensembl:ENSG00000104267(gene)|ensembl:ENST00000285379(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0004064"(arylesterase activity)|go:"GO:0004089"(carbonate dehydratase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0006730"(one-carbon metabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009268"(response to pH)|go:"GO:0010043"(response to zinc ion)|go:"GO:0015670"(carbon dioxide transport)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016836"(hydro-lyase activity)|go:"GO:0030424"(axon)|go:"GO:0032849"(positive regulation of cellular pH reduction)|go:"GO:0038166"(angiotensin-activated signaling pathway)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0043627"(response to estrogen)|go:"GO:0044070"(regulation of anion transport)|rcsb pdb:1G4O|rcsb pdb:1G52|rcsb pdb:1G53|rcsb pdb:1G54|rcsb pdb:1H4N|rcsb pdb:1H9N|rcsb pdb:1H9Q|rcsb pdb:1HCA|rcsb pdb:1G4J|rcsb pdb:1HEA|rcsb pdb:1HEB|rcsb pdb:1HEC|rcsb pdb:1HED|rcsb pdb:1HVA|rcsb pdb:1I8Z|rcsb pdb:1I90|rcsb pdb:1I91|rcsb pdb:1I9L|rcsb pdb:1I9M|rcsb pdb:1I9N|rcsb pdb:1I9O|rcsb pdb:1I9P|rcsb pdb:3QYK|rcsb pdb:3R16|rcsb pdb:3R17|rcsb pdb:3RG3|rcsb pdb:3RG4|rcsb pdb:3RGE|rcsb pdb:3RJ7|rcsb pdb:3RLD|rcsb pdb:3RYJ|rcsb pdb:3RYV|rcsb pdb:3RYX|rcsb pdb:3RYY|rcsb pdb:3RYZ|rcsb pdb:3RZ0|rcsb pdb:3RZ1|rcsb pdb:3PYK|rcsb pdb:3RZ5|rcsb pdb:3RZ7|rcsb pdb:3RZ8|rcsb pdb:3S71|rcsb pdb:3S72|rcsb pdb:3S73|rcsb pdb:3S74|rcsb pdb:3S75|rcsb pdb:3S76|rcsb pdb:3S77|rcsb pdb:3S78|rcsb pdb:3S8X|rcsb pdb:3S9T|rcsb pdb:3SAP|rcsb pdb:3SAX|rcsb pdb:3SBH|rcsb pdb:3SBI|rcsb pdb:3T5U|rcsb pdb:3T5Z|rcsb pdb:3T82|rcsb pdb:3T83|rcsb pdb:3T84|rcsb pdb:3T85|rcsb pdb:3TMJ|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045177"(apical part of cell)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0048545"(response to steroid hormone)|go:"GO:0051453"(regulation of intracellular pH)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:2001150"(positive regulation of dipeptide transmembrane transport)|interpro:IPR001148(Carbonic anhydrase, eukaryotic)|interpro:IPR018338|interpro:IPR023561|interpro:IPR036398|mint:P00918|rcsb pdb:12CA|rcsb pdb:1A42|rcsb pdb:1AM6|rcsb pdb:1AVN|rcsb pdb:1BCD|rcsb pdb:1BIC|rcsb pdb:1BN1|rcsb pdb:1BN3|rcsb pdb:1BN4|rcsb pdb:1BNM|rcsb pdb:1BNN|rcsb pdb:1BNQ|rcsb pdb:1BNT|rcsb pdb:1BNU|rcsb pdb:1BNV|rcsb pdb:5NXI|rcsb pdb:5NY3|rcsb pdb:5NY6|rcsb pdb:5NYA|rcsb pdb:5O07|rcsb pdb:5OGN|rcsb pdb:5OGO|rcsb pdb:5OGP|rcsb pdb:5SZ0|rcsb pdb:5SZ1|rcsb pdb:5SZ2|rcsb pdb:5NXM|rcsb pdb:5NXO|rcsb pdb:5SZ3|rcsb pdb:5SZ4|rcsb pdb:5SZ5|rcsb pdb:5SZ6|rcsb pdb:5NXP|rcsb pdb:5SZ7|rcsb pdb:5T71|rcsb pdb:5T72|rcsb pdb:5T74|rcsb pdb:5T75|rcsb pdb:5TFX|rcsb pdb:5TH4|rcsb pdb:5THI|rcsb pdb:5THJ|rcsb pdb:5THN|rcsb pdb:5TI0|rcsb pdb:5TXY|rcsb pdb:5TY1|rcsb pdb:5TY8|rcsb pdb:5TY9|rcsb pdb:5NXV|rcsb pdb:5NXW|rcsb pdb:5NY1|rcsb pdb:5TYA|rcsb pdb:5U0D|rcsb pdb:5U0E|rcsb pdb:5U0F|rcsb pdb:6WKA|rcsb pdb:6WQ4|rcsb pdb:6WQ5|rcsb pdb:6WQ7|rcsb pdb:6WQ8|rcsb pdb:6WQ9|rcsb pdb:6XVH|rcsb pdb:6XWZ|rcsb pdb:6XXT|rcsb pdb:6YH4|rcsb pdb:6YH5|rcsb pdb:6YH6|rcsb pdb:6YH7|rcsb pdb:6YH8|rcsb pdb:6YH9|rcsb pdb:6YHA|rcsb pdb:6YHB|rcsb pdb:6YHC|rcsb pdb:6YJ3|rcsb pdb:6YKC|rcsb pdb:6YKH|rcsb pdb:6YMA|rcsb pdb:6YMB|rcsb pdb:6YO2|rcsb pdb:6YO4|rcsb pdb:6YO7|rcsb pdb:6YOI|rcsb pdb:6YOK|rcsb pdb:6YOL|rcsb pdb:6YPW|rcsb pdb:6YQT|rcsb pdb:6YQU|rcsb pdb:6YRI|rcsb pdb:6YZJ|rcsb pdb:6YZK|rcsb pdb:6YZL|rcsb pdb:6YZT|rcsb pdb:6YZU|rcsb pdb:6YZV|rcsb pdb:6YZM|rcsb pdb:6YZW|rcsb pdb:6YZX|rcsb pdb:6Z04|rcsb pdb:6ZR8|rcsb pdb:6YZN|rcsb pdb:6YZO|rcsb pdb:7BI5|rcsb pdb:7CA2|rcsb pdb:7JNR|rcsb pdb:7JNV|rcsb pdb:7JNW|rcsb pdb:7JNX|rcsb pdb:7JNZ|rcsb pdb:7JO0|rcsb pdb:7JO1|rcsb pdb:7JO2|rcsb pdb:7JO3|rcsb pdb:7JOB|rcsb pdb:7JOC|rcsb pdb:7K6I|rcsb pdb:7K6J|rcsb pdb:7K6K|rcsb pdb:7K6L|rcsb pdb:7K6T|rcsb pdb:7K6U|rcsb pdb:7K6X|rcsb pdb:7K6Z|rcsb pdb:8CA2|rcsb pdb:9CA2|reactome:R-HSA-1237044|reactome:R-HSA-1247673|reactome:R-HSA-1475029|rcsb pdb:6YZP|rcsb pdb:6YZQ|rcsb pdb:6YZR|rcsb pdb:6YZS psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:kcGXFKKr/9BwysWkDkqi2iUmTCg9606 rogid:Er5rv/L2XS7uyrm/fPxFFsN+EsU9606 intact-crc:4E2159AB3827EA15|rigid:g3ZxzXGqanLtXGntmlYvrLvUjac false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H9J4 uniprotkb:O60783 intact:EBI-2513638|uniprotkb:Q6P9B4|uniprotkb:Q3C166|uniprotkb:A2RUE3|uniprotkb:B5MDA5|uniprotkb:Q0VIN8 intact:EBI-1045956|uniprotkb:Q5R358|ensembl:ENSP00000420714 psi-mi:ubp42_human(display_long)|uniprotkb:USP42(gene name)|psi-mi:USP42(display_short)|uniprotkb:Ubiquitin-specific-processing protease 42(gene name synonym)|uniprotkb:Deubiquitinating enzyme 42(gene name synonym)|uniprotkb:Ubiquitin thioesterase 42(gene name synonym) psi-mi:rt14_human(display_long)|uniprotkb:MRPS14(gene name)|psi-mi:MRPS14(display_short)|uniprotkb:Mitochondrial small ribosomal subunit protein uS14m(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513636|imex:IM-12079-85 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007283"(spermatogenesis)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030154"(cell differentiation)|go:"GO:0042981"(regulation of apoptotic process)|reactome:R-HSA-5689880|interpro:IPR028889|interpro:IPR038765|refseq:NP_115548.1|interpro:IPR018200|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|mint:Q9H9J4 refseq:NP_071383.1|ensembl:ENSG00000120333(gene)|ensembl:ENST00000476371(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005761"(mitochondrial ribosome)|go:"GO:0005763"(mitochondrial small ribosomal subunit)|go:"GO:0006412"(translation)|go:"GO:0015935"(small ribosomal subunit)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032543"(mitochondrial translation)|interpro:IPR001209(Ribosomal protein S14)|mint:O60783|rcsb pdb:3J9M|rcsb pdb:6NU2|rcsb pdb:6NU3|rcsb pdb:6RW4|rcsb pdb:6RW5|rcsb pdb:6VLZ|rcsb pdb:6VMI|rcsb pdb:6ZM5|rcsb pdb:6ZM6|rcsb pdb:6ZS9|rcsb pdb:6ZSA|rcsb pdb:6ZSB|rcsb pdb:6ZSC|rcsb pdb:6ZSD|rcsb pdb:6ZSE|rcsb pdb:6ZSG|rcsb pdb:7A5F|rcsb pdb:7A5G|rcsb pdb:7A5I|rcsb pdb:7A5K|rcsb pdb:7L08|rcsb pdb:7OG4|reactome:R-HSA-5368286|go:"GO:0005739"(mitochondrion)|reactome:R-HSA-5389840|reactome:R-HSA-5419276 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:kcGXFKKr/9BwysWkDkqi2iUmTCg9606 rogid:IW06v3pp8xJJXxPcizKjsNIZi/I9606 intact-crc:4E2159AB3827EA15|rigid:g3ZxzXGqanLtXGntmlYvrLvUjac false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H9J4 uniprotkb:Q9H6S0 intact:EBI-2513638|uniprotkb:Q6P9B4|uniprotkb:Q3C166|uniprotkb:A2RUE3|uniprotkb:B5MDA5|uniprotkb:Q0VIN8 intact:EBI-1057466|uniprotkb:B2RP66|ensembl:ENSP00000161863 psi-mi:ubp42_human(display_long)|uniprotkb:USP42(gene name)|psi-mi:USP42(display_short)|uniprotkb:Ubiquitin-specific-processing protease 42(gene name synonym)|uniprotkb:Deubiquitinating enzyme 42(gene name synonym)|uniprotkb:Ubiquitin thioesterase 42(gene name synonym) psi-mi:ytdc2_human(display_long)|uniprotkb:YTHDC2(gene name)|psi-mi:YTHDC2(display_short)|uniprotkb:YTH domain-containing protein 2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513636|imex:IM-12079-85 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007283"(spermatogenesis)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030154"(cell differentiation)|go:"GO:0042981"(regulation of apoptotic process)|reactome:R-HSA-5689880|interpro:IPR028889|interpro:IPR038765|refseq:NP_115548.1|interpro:IPR018200|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|mint:Q9H9J4 refseq:NP_073739.3|ensembl:ENSG00000047188(gene)|ensembl:ENST00000161863(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0007286"(spermatid development)|go:"GO:0008186"(ATP-dependent activity, acting on RNA)|go:"GO:0034458"(3'-5' RNA helicase activity)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0044829"(positive regulation by host of viral genome replication)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048599"(oocyte development)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0051729"(germline cell cycle switching, mitotic to meiotic cell cycle)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1990247"(N6-methyladenosine-containing RNA binding)|interpro:IPR001374(Single-stranded nucleic acid binding R3H)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR002110(Ankyrin)|interpro:IPR007275(YT521-B-like protein)|interpro:IPR007502(Helicase-associated region)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR011709(Region of unknown function DUF1605)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR027417|interpro:IPR031083|interpro:IPR034083|interpro:IPR036770|interpro:IPR036867|mint:Q9H6S0|rcsb pdb:2YU6|rcsb pdb:6K6U|refseq:XP_016865219.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:kcGXFKKr/9BwysWkDkqi2iUmTCg9606 rogid:8J8b1Q3F6rfXUwtp7EOeU2y89Lc9606 intact-crc:4E2159AB3827EA15|rigid:g3ZxzXGqanLtXGntmlYvrLvUjac false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H9J4 uniprotkb:P82930 intact:EBI-2513638|uniprotkb:Q6P9B4|uniprotkb:Q3C166|uniprotkb:A2RUE3|uniprotkb:B5MDA5|uniprotkb:Q0VIN8 intact:EBI-1048516|uniprotkb:Q9BVI7|ensembl:ENSP00000380531 psi-mi:ubp42_human(display_long)|uniprotkb:USP42(gene name)|psi-mi:USP42(display_short)|uniprotkb:Ubiquitin-specific-processing protease 42(gene name synonym)|uniprotkb:Deubiquitinating enzyme 42(gene name synonym)|uniprotkb:Ubiquitin thioesterase 42(gene name synonym) psi-mi:rt34_human(display_long)|uniprotkb:MRPS34(gene name)|psi-mi:MRPS34(display_short)|uniprotkb:Mitochondrial small ribosomal subunit protein mS34(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513636|imex:IM-12079-85 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007283"(spermatogenesis)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030154"(cell differentiation)|go:"GO:0042981"(regulation of apoptotic process)|reactome:R-HSA-5689880|interpro:IPR028889|interpro:IPR038765|refseq:NP_115548.1|interpro:IPR018200|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|mint:Q9H9J4 refseq:NP_001287829.1|refseq:NP_076425.1|ensembl:ENSG00000074071(gene)|ensembl:ENST00000397375(transcript)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005763"(mitochondrial small ribosomal subunit)|go:"GO:0032543"(mitochondrial translation)|interpro:IPR032053|mint:P82930|rcsb pdb:3J9M|rcsb pdb:6NU2|rcsb pdb:6RW4|rcsb pdb:6RW5|rcsb pdb:6VLZ|rcsb pdb:6VMI|rcsb pdb:6ZM5|rcsb pdb:6ZM6|rcsb pdb:6ZS9|rcsb pdb:6ZSA|rcsb pdb:6ZSB|rcsb pdb:6ZSC|rcsb pdb:6ZSD|rcsb pdb:6ZSE|rcsb pdb:6ZSG|rcsb pdb:7A5F|rcsb pdb:7A5G|rcsb pdb:7A5I|rcsb pdb:7A5K|rcsb pdb:7L08|rcsb pdb:7OG4|reactome:R-HSA-5368286|reactome:R-HSA-5389840|reactome:R-HSA-5419276 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:kcGXFKKr/9BwysWkDkqi2iUmTCg9606 rogid:UTZkYPSJqThFKwoB7D5sH6g0zuc9606 intact-crc:4E2159AB3827EA15|rigid:g3ZxzXGqanLtXGntmlYvrLvUjac false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H9J4 uniprotkb:P82921 intact:EBI-2513638|uniprotkb:Q6P9B4|uniprotkb:Q3C166|uniprotkb:A2RUE3|uniprotkb:B5MDA5|uniprotkb:Q0VIN8 intact:EBI-2372155|uniprotkb:Q9BST6|uniprotkb:A0A075B746|uniprotkb:Q5TB11|ensembl:ENSP00000461930|ensembl:ENSP00000480129 psi-mi:ubp42_human(display_long)|uniprotkb:USP42(gene name)|psi-mi:USP42(display_short)|uniprotkb:Ubiquitin-specific-processing protease 42(gene name synonym)|uniprotkb:Deubiquitinating enzyme 42(gene name synonym)|uniprotkb:Ubiquitin thioesterase 42(gene name synonym) psi-mi:rt21_human(display_long)|uniprotkb:MRPS21(gene name)|psi-mi:MRPS21(display_short)|uniprotkb:RPMS21(gene name synonym)|uniprotkb:MDS016(orf name)|uniprotkb:Mitochondrial small ribosomal subunit protein bS21m(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513636|imex:IM-12079-85 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007283"(spermatogenesis)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030154"(cell differentiation)|go:"GO:0042981"(regulation of apoptotic process)|reactome:R-HSA-5689880|interpro:IPR028889|interpro:IPR038765|refseq:NP_115548.1|interpro:IPR018200|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|mint:Q9H9J4 refseq:NP_061870.1|refseq:NP_114107.1|ensembl:ENSG00000266472(gene)|ensembl:ENST00000581066(transcript)|ensembl:ENST00000614145(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005763"(mitochondrial small ribosomal subunit)|go:"GO:0006412"(translation)|go:"GO:0032543"(mitochondrial translation)|interpro:IPR001911(Ribosomal protein S21)|interpro:IPR038380|mint:P82921|rcsb pdb:3J9M|rcsb pdb:6NU2|rcsb pdb:6NU3|rcsb pdb:6RW4|rcsb pdb:6RW5|rcsb pdb:6VLZ|rcsb pdb:6VMI|rcsb pdb:6ZM5|rcsb pdb:6ZM6|rcsb pdb:6ZS9|rcsb pdb:6ZSA|rcsb pdb:6ZSB|rcsb pdb:6ZSC|rcsb pdb:6ZSE|rcsb pdb:6ZSG|rcsb pdb:7A5F|rcsb pdb:7A5G|rcsb pdb:7A5I|rcsb pdb:7A5K|rcsb pdb:7L08|rcsb pdb:7OG4|reactome:R-HSA-5368286|reactome:R-HSA-5389840|reactome:R-HSA-5419276 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:kcGXFKKr/9BwysWkDkqi2iUmTCg9606 rogid:AGyHmum6PLo+BxY+wgQvG2894A49606 intact-crc:4E2159AB3827EA15|rigid:g3ZxzXGqanLtXGntmlYvrLvUjac false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H9J4 uniprotkb:O43865 intact:EBI-2513638|uniprotkb:Q6P9B4|uniprotkb:Q3C166|uniprotkb:A2RUE3|uniprotkb:B5MDA5|uniprotkb:Q0VIN8 intact:EBI-2371423|uniprotkb:Q2TAJ6|uniprotkb:Q502W8|uniprotkb:Q5VSM0|uniprotkb:Q6P171|uniprotkb:Q96PK4|uniprotkb:Q9UG84|uniprotkb:B4E168|ensembl:ENSP00000358814 psi-mi:ubp42_human(display_long)|uniprotkb:USP42(gene name)|psi-mi:USP42(display_short)|uniprotkb:Ubiquitin-specific-processing protease 42(gene name synonym)|uniprotkb:Deubiquitinating enzyme 42(gene name synonym)|uniprotkb:Ubiquitin thioesterase 42(gene name synonym) psi-mi:sahh2_human(display_long)|uniprotkb:AHCYL1(gene name)|psi-mi:AHCYL1(display_short)|uniprotkb:DCAL(gene name synonym)|uniprotkb:XPVKONA(gene name synonym)|uniprotkb:S-adenosyl-L-homocysteine hydrolase 2(gene name synonym)|uniprotkb:DC-expressed AHCY-like molecule(gene name synonym)|uniprotkb:Putative adenosylhomocysteinase 2(gene name synonym)|uniprotkb:"IP(3)Rs binding protein released with IP(3)"(gene name synonym)|uniprotkb:IRBIT(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513636|imex:IM-12079-85 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007283"(spermatogenesis)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030154"(cell differentiation)|go:"GO:0042981"(regulation of apoptotic process)|reactome:R-HSA-5689880|interpro:IPR028889|interpro:IPR038765|refseq:NP_115548.1|interpro:IPR018200|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|mint:Q9H9J4 refseq:NP_001229602.1|refseq:NP_001229603.1|refseq:NP_001229604.1|refseq:NP_001229605.1|refseq:NP_006612.2|ensembl:ENSG00000168710(gene)|ensembl:ENST00000369799(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006378"(mRNA polyadenylation)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0006730"(one-carbon metabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0010765"(positive regulation of sodium ion transport)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0031440"(regulation of mRNA 3'-end processing)|go:"GO:0032412"(regulation of ion transmembrane transporter activity)|go:"GO:0033353"(S-adenosylmethionine cycle)|go:"GO:0038166"(angiotensin-activated signaling pathway)|go:"GO:0042045"(epithelial fluid transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0044070"(regulation of anion transport)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0051592"(response to calcium ion)|go:"GO:0070062"(extracellular exosome)|go:"GO:1990456"(mitochondrion-endoplasmic reticulum membrane tethering)|interpro:IPR000043(S-adenosyl-L-homocysteine hydrolase)|interpro:IPR015878(S-adenosyl-L-homocysteine hydrolase, NAD binding)|interpro:IPR020082|interpro:IPR036291|interpro:IPR042172|mint:O43865|rcsb pdb:3MTG|reactome:R-HSA-112043|reactome:R-HSA-1489509|reactome:R-HSA-2029485|reactome:R-HSA-2871809|reactome:R-HSA-422356|reactome:R-HSA-5218921|reactome:R-HSA-5578775|reactome:R-HSA-5607763|reactome:R-HSA-9664323|reactome:R-HSA-983695 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:kcGXFKKr/9BwysWkDkqi2iUmTCg9606 rogid:uwZ+P9SdKadoVn01p/b8qHp6egk9606 intact-crc:4E2159AB3827EA15|rigid:g3ZxzXGqanLtXGntmlYvrLvUjac false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H9J4 uniprotkb:Q9UQ35 intact:EBI-2513638|uniprotkb:Q6P9B4|uniprotkb:Q3C166|uniprotkb:A2RUE3|uniprotkb:B5MDA5|uniprotkb:Q0VIN8 intact:EBI-1050142|uniprotkb:A6NKB9|uniprotkb:Q9UHA8|uniprotkb:Q9UQ36|uniprotkb:Q9UQ37|uniprotkb:Q9UQ38|uniprotkb:Q9UQ40|uniprotkb:O15038|uniprotkb:O94803|uniprotkb:Q6NSL3|uniprotkb:Q6PIM3|uniprotkb:Q6PK40|uniprotkb:Q8IW17|uniprotkb:Q96GY7|uniprotkb:Q9P0G1|uniprotkb:D3DU97|ensembl:ENSP00000301740 psi-mi:ubp42_human(display_long)|uniprotkb:USP42(gene name)|psi-mi:USP42(display_short)|uniprotkb:Ubiquitin-specific-processing protease 42(gene name synonym)|uniprotkb:Deubiquitinating enzyme 42(gene name synonym)|uniprotkb:Ubiquitin thioesterase 42(gene name synonym) psi-mi:srrm2_human(display_long)|uniprotkb:Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa(gene name synonym)|uniprotkb:Splicing coactivator subunit SRm300(gene name synonym)|uniprotkb:300 kDa nuclear matrix antigen(gene name synonym)|uniprotkb:SRRM2(gene name)|psi-mi:SRRM2(display_short)|uniprotkb:KIAA0324(gene name synonym)|uniprotkb:SRL300(gene name synonym)|uniprotkb:SRM300(gene name synonym)|uniprotkb:HSPC075(orf name)|uniprotkb:Tax-responsive enhancer element-binding protein 803(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513636|imex:IM-12079-85 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007283"(spermatogenesis)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030154"(cell differentiation)|go:"GO:0042981"(regulation of apoptotic process)|reactome:R-HSA-5689880|interpro:IPR028889|interpro:IPR038765|refseq:NP_115548.1|interpro:IPR018200|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|mint:Q9H9J4 refseq:NP_057417.3|ensembl:ENSG00000167978(gene)|ensembl:ENST00000301740(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0015030"(Cajal body)|go:"GO:0016607"(nuclear speck)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0070742"(C2H2 zinc finger domain binding)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071007"(U2-type catalytic step 2 spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|interpro:IPR013170(mRNA splicing factor, Cwf21)|interpro:IPR024945|mint:Q9UQ35|rcsb pdb:5MQF|rcsb pdb:5XJC|rcsb pdb:5YZG|rcsb pdb:5Z56|rcsb pdb:5Z57|rcsb pdb:6FF4|rcsb pdb:6FF7|rcsb pdb:6ICZ|rcsb pdb:6QDV|rcsb pdb:6ZYM|rcsb pdb:7A5P|rcsb pdb:7DVQ|reactome:R-HSA-72163 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:kcGXFKKr/9BwysWkDkqi2iUmTCg9606 rogid:3yyPAOaCzKSCEg5guJSbq0MWrHI9606 intact-crc:4E2159AB3827EA15|rigid:g3ZxzXGqanLtXGntmlYvrLvUjac false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H9J4 uniprotkb:Q9H6W3 intact:EBI-2513638|uniprotkb:Q6P9B4|uniprotkb:Q3C166|uniprotkb:A2RUE3|uniprotkb:B5MDA5|uniprotkb:Q0VIN8 intact:EBI-2513645|ensembl:ENSP00000477507|uniprotkb:B4DT02 psi-mi:ubp42_human(display_long)|uniprotkb:USP42(gene name)|psi-mi:USP42(display_short)|uniprotkb:Ubiquitin-specific-processing protease 42(gene name synonym)|uniprotkb:Deubiquitinating enzyme 42(gene name synonym)|uniprotkb:Ubiquitin thioesterase 42(gene name synonym) psi-mi:riox1_human(display_long)|uniprotkb:RIOX1(gene name)|psi-mi:RIOX1(display_short)|uniprotkb:60S ribosomal protein L8 histidine hydroxylase(gene name synonym)|uniprotkb:Bifunctional lysine-specific demethylase and histidyl-hydroxylase NO66(gene name synonym)|uniprotkb:C14orf169(gene name synonym)|uniprotkb:Histone lysine demethylase NO66(gene name synonym)|uniprotkb:MAPJD(gene name synonym)|uniprotkb:Myc-associated protein with JmjC domain(gene name synonym)|uniprotkb:NO66(gene name synonym)|uniprotkb:Nucleolar protein 66(gene name synonym)|uniprotkb:Ribosomal oxygenase NO66(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513636|imex:IM-12079-85 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007283"(spermatogenesis)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030154"(cell differentiation)|go:"GO:0042981"(regulation of apoptotic process)|reactome:R-HSA-5689880|interpro:IPR028889|interpro:IPR038765|refseq:NP_115548.1|interpro:IPR018200|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|mint:Q9H9J4 ensembl:ENST00000304061(transcript)|go:"GO:0005506"(iron ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0016706"(2-oxoglutarate-dependent dioxygenase activity)|go:"GO:0032453"(histone H3-methyl-lysine-4 demethylase activity)|go:"GO:0034720"(histone H3-K4 demethylation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0051864"(histone H3-methyl-lysine-36 demethylase activity)|go:"GO:0070544"(histone H3-K36 demethylation)|interpro:IPR003347(Transcription factor jumonji/aspartyl beta-hydroxylase)|interpro:IPR013109(Cupin 4)|interpro:IPR039994|mint:Q9H6W3|rcsb pdb:4CCJ|rcsb pdb:4CCK|rcsb pdb:4CCM|rcsb pdb:4CCN|ensembl:ENSG00000170468(gene)|rcsb pdb:4CCO|rcsb pdb:4DIQ|rcsb pdb:4E4H|rcsb pdb:4Y33|rcsb pdb:4Y4R|rcsb pdb:4Y3O|refseq:NP_078920.2|dip:DIP-53768N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:kcGXFKKr/9BwysWkDkqi2iUmTCg9606 rogid:RsTFUH3upRu11eleWymp6N7cEpM9606 intact-crc:4E2159AB3827EA15|rigid:g3ZxzXGqanLtXGntmlYvrLvUjac false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H9J4 uniprotkb:P82673 intact:EBI-2513638|uniprotkb:Q6P9B4|uniprotkb:Q3C166|uniprotkb:A2RUE3|uniprotkb:B5MDA5|uniprotkb:Q0VIN8 intact:EBI-2513649|ensembl:ENSP00000081029|uniprotkb:Q6P4C6|uniprotkb:Q7L1M6|uniprotkb:Q9HC14|uniprotkb:Q96AI0|uniprotkb:Q32LZ1|uniprotkb:Q9H044|uniprotkb:Q9P1R5|uniprotkb:Q8NBP4 psi-mi:ubp42_human(display_long)|uniprotkb:USP42(gene name)|psi-mi:USP42(display_short)|uniprotkb:Ubiquitin-specific-processing protease 42(gene name synonym)|uniprotkb:Deubiquitinating enzyme 42(gene name synonym)|uniprotkb:Ubiquitin thioesterase 42(gene name synonym) psi-mi:rt35_human(display_long)|uniprotkb:MRPS35(gene name)|psi-mi:MRPS35(display_short)|uniprotkb:MRPS28(gene name synonym)|uniprotkb:28S ribosomal protein S28, mitochondrial(gene name synonym)|uniprotkb:Mitochondrial small ribosomal subunit protein mS35(gene name synonym)|uniprotkb:HDCMD11P(orf name)|uniprotkb:MDS023(orf name)|uniprotkb:PSEC0213(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513636|imex:IM-12079-85 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007283"(spermatogenesis)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030154"(cell differentiation)|go:"GO:0042981"(regulation of apoptotic process)|reactome:R-HSA-5689880|interpro:IPR028889|interpro:IPR038765|refseq:NP_115548.1|interpro:IPR018200|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|mint:Q9H9J4 ensembl:ENSG00000061794(gene)|ensembl:ENST00000081029(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005763"(mitochondrial small ribosomal subunit)|go:"GO:0032543"(mitochondrial translation)|go:"GO:0042769"(obsolete DNA damage response, detection of DNA damage)|interpro:IPR019349|interpro:IPR039848|rcsb pdb:3J9M|rcsb pdb:6NU2|rcsb pdb:6NU3|rcsb pdb:6RW4|rcsb pdb:6RW5|rcsb pdb:6VLZ|rcsb pdb:6VMI|rcsb pdb:6ZM5|rcsb pdb:6ZM6|rcsb pdb:6ZS9|rcsb pdb:6ZSA|rcsb pdb:6ZSB|rcsb pdb:6ZSC|rcsb pdb:6ZSD|rcsb pdb:6ZSE|rcsb pdb:6ZSG|rcsb pdb:7A5F|rcsb pdb:7A5G|rcsb pdb:7A5I|rcsb pdb:7A5K|rcsb pdb:7L08|rcsb pdb:7OG4|reactome:R-HSA-5368286|reactome:R-HSA-5389840|reactome:R-HSA-5419276|refseq:NP_001177793.1|refseq:NP_068593.2 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:kcGXFKKr/9BwysWkDkqi2iUmTCg9606 rogid:L7fhBRRkth1ePVbRtuVTvC5zcR09606 intact-crc:4E2159AB3827EA15|rigid:g3ZxzXGqanLtXGntmlYvrLvUjac false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H9J4 uniprotkb:O95714 intact:EBI-2513638|uniprotkb:Q6P9B4|uniprotkb:Q3C166|uniprotkb:A2RUE3|uniprotkb:B5MDA5|uniprotkb:Q0VIN8 intact:EBI-1058922|uniprotkb:Q86SV7|uniprotkb:Q86SV8|uniprotkb:Q86SV9|uniprotkb:Q86YY3|uniprotkb:Q86YY4|uniprotkb:Q86YY5|uniprotkb:Q86YY6|uniprotkb:Q86YY7|uniprotkb:Q86YY8|uniprotkb:Q86YY9|uniprotkb:Q86YZ0|uniprotkb:Q86YZ1|intact:EBI-1104961|intact:EBI-28977852|ensembl:ENSP00000261609 psi-mi:ubp42_human(display_long)|uniprotkb:USP42(gene name)|psi-mi:USP42(display_short)|uniprotkb:Ubiquitin-specific-processing protease 42(gene name synonym)|uniprotkb:Deubiquitinating enzyme 42(gene name synonym)|uniprotkb:Ubiquitin thioesterase 42(gene name synonym) psi-mi:herc2_human(display_long)|uniprotkb:HERC2(gene name)|psi-mi:HERC2(display_short)|uniprotkb:HECT domain and RCC1-like domain-containing protein 2(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase HERC2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513636|imex:IM-12079-85 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007283"(spermatogenesis)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030154"(cell differentiation)|go:"GO:0042981"(regulation of apoptotic process)|reactome:R-HSA-5689880|interpro:IPR028889|interpro:IPR038765|refseq:NP_115548.1|interpro:IPR018200|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|mint:Q9H9J4 ensembl:ENSP00000261609|refseq:NP_004658.3|ensembl:ENSG00000128731(gene)|ensembl:ENST00000261609(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006281"(DNA repair)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032183"(SUMO binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR000433(Zinc finger, ZZ-type)|interpro:IPR000569(HECT)|interpro:IPR001199(Cytochrome b5)|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR006624(Beta-propeller repeat TECPR)|interpro:IPR008979(Galactose-binding like)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR010606(Mib-herc2)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR021097|interpro:IPR035983|interpro:IPR036400|interpro:IPR037252|interpro:IPR037976|interpro:IPR041987|interpro:IPR043145|mint:O95714|rcsb pdb:2KEO|go:"GO:0031625"(ubiquitin protein ligase binding)|rcsb pdb:3KCI|rcsb pdb:4L1M|rcsb pdb:6WW4|reactome:R-HSA-3108214|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473|reactome:R-HSA-983168|rcsb pdb:6WW3|dip:DIP-37632N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:kcGXFKKr/9BwysWkDkqi2iUmTCg9606 rogid:ejMTmb0F9pM7zfHbRscV1rIRgSw9606 intact-crc:4E2159AB3827EA15|rigid:g3ZxzXGqanLtXGntmlYvrLvUjac false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H9J4 uniprotkb:Q96S59 intact:EBI-2513638|uniprotkb:Q6P9B4|uniprotkb:Q3C166|uniprotkb:A2RUE3|uniprotkb:B5MDA5|uniprotkb:Q0VIN8 intact:EBI-636085|uniprotkb:A0PJA2|uniprotkb:O94764|uniprotkb:Q6P3T7|uniprotkb:Q7LBR2|uniprotkb:Q7Z7F9|ensembl:ENSP00000011619|uniprotkb:B2R8E1 psi-mi:ubp42_human(display_long)|uniprotkb:USP42(gene name)|psi-mi:USP42(display_short)|uniprotkb:Ubiquitin-specific-processing protease 42(gene name synonym)|uniprotkb:Deubiquitinating enzyme 42(gene name synonym)|uniprotkb:Ubiquitin thioesterase 42(gene name synonym) psi-mi:ranb9_human(display_long)|uniprotkb:RanBP7(gene name synonym)|uniprotkb:Ran-binding protein M(gene name synonym)|uniprotkb:BPM90(gene name synonym)|uniprotkb:BPM-L(gene name synonym)|uniprotkb:RANBP9(gene name)|psi-mi:RANBP9(display_short)|uniprotkb:RANBPM(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513636|imex:IM-12079-85 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007283"(spermatogenesis)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030154"(cell differentiation)|go:"GO:0042981"(regulation of apoptotic process)|reactome:R-HSA-5689880|interpro:IPR028889|interpro:IPR038765|refseq:NP_115548.1|interpro:IPR018200|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|mint:Q9H9J4 refseq:NP_005484.2|ensembl:ENSG00000010017(gene)|ensembl:ENST00000011619(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007020"(microtubule nucleation)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0016604"(nuclear body)|go:"GO:0019899"(enzyme binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR006594(LisH dimerisation motif)|interpro:IPR006595(CTLH, C-terminal to LisH motif)|interpro:IPR013144(CT11-RanBPM)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR024964|interpro:IPR035782|interpro:IPR043136|mint:Q96S59|rcsb pdb:5JI7|rcsb pdb:5JI9|rcsb pdb:5JIU|rcsb pdb:7NSC|reactome:R-HSA-373760|reactome:R-HSA-5673001|go:"GO:1902993"(positive regulation of amyloid precursor protein catabolic process)|reactome:R-HSA-8851805|refseq:XP_006715008.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:kcGXFKKr/9BwysWkDkqi2iUmTCg9606 rogid:7jybZidQAgnkobKmGJhZ9xsEeH09606 intact-crc:4E2159AB3827EA15|rigid:g3ZxzXGqanLtXGntmlYvrLvUjac false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H9J4 uniprotkb:P22830 intact:EBI-2513638|uniprotkb:Q6P9B4|uniprotkb:Q3C166|uniprotkb:A2RUE3|uniprotkb:B5MDA5|uniprotkb:Q0VIN8 intact:EBI-1390356|uniprotkb:Q8IXN1|uniprotkb:Q8NAN0|uniprotkb:A8KA72|ensembl:ENSP00000262093 psi-mi:ubp42_human(display_long)|uniprotkb:USP42(gene name)|psi-mi:USP42(display_short)|uniprotkb:Ubiquitin-specific-processing protease 42(gene name synonym)|uniprotkb:Deubiquitinating enzyme 42(gene name synonym)|uniprotkb:Ubiquitin thioesterase 42(gene name synonym) psi-mi:hemh_human(display_long)|uniprotkb:Protoheme ferro-lyase(gene name synonym)|uniprotkb:Heme synthase(gene name synonym)|uniprotkb:FECH(gene name)|psi-mi:FECH(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513636|imex:IM-12079-85 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007283"(spermatogenesis)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030154"(cell differentiation)|go:"GO:0042981"(regulation of apoptotic process)|reactome:R-HSA-5689880|interpro:IPR028889|interpro:IPR038765|refseq:NP_115548.1|interpro:IPR018200|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|mint:Q9H9J4 refseq:NP_000131.2|refseq:NP_001012533.1|dip:DIP-39632N|ensembl:ENSG00000066926(gene)|ensembl:ENST00000262093(transcript)|go:"GO:0004325"(ferrochelatase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0006783"(heme biosynthetic process)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0009416"(response to light stimulus)|go:"GO:0010288"(response to lead ion)|go:"GO:0017085"(response to insecticide)|go:"GO:0042493"|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045471"(response to ethanol)|go:"GO:0046501"(protoporphyrinogen IX metabolic process)|go:"GO:0046685"(response to arsenic-containing substance)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0051597"(response to methylmercury)|go:"GO:0070541"(response to platinum ion)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|interpro:IPR001015(Ferrochelatase)|interpro:IPR019772|interpro:IPR033644|interpro:IPR033659|rcsb pdb:1HRK|rcsb pdb:2HRC|rcsb pdb:2HRE|rcsb pdb:2PNJ|rcsb pdb:2PO5|rcsb pdb:2PO7|rcsb pdb:2QD1|rcsb pdb:2QD2|rcsb pdb:2QD3|rcsb pdb:2QD4|rcsb pdb:2QD5|rcsb pdb:3AQI|rcsb pdb:3HCN|rcsb pdb:3HCO|rcsb pdb:3HCP|rcsb pdb:3HCR|rcsb pdb:3W1W|rcsb pdb:4F4D|rcsb pdb:4KLA|rcsb pdb:4KLC|rcsb pdb:4KLR|rcsb pdb:4KMM|rcsb pdb:4MK4|reactome:R-HSA-189451 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:kcGXFKKr/9BwysWkDkqi2iUmTCg9606 rogid:Rh4ulxUAnCedNUVAABAhY4iOnuo9606 intact-crc:4E2159AB3827EA15|rigid:g3ZxzXGqanLtXGntmlYvrLvUjac false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H9J4 uniprotkb:Q92665 intact:EBI-2513638|uniprotkb:Q6P9B4|uniprotkb:Q3C166|uniprotkb:A2RUE3|uniprotkb:B5MDA5|uniprotkb:Q0VIN8 intact:EBI-720602|uniprotkb:Q8WTV8|uniprotkb:Q5VYC8|uniprotkb:B2RCS3|ensembl:ENSP00000315397 psi-mi:ubp42_human(display_long)|uniprotkb:USP42(gene name)|psi-mi:USP42(display_short)|uniprotkb:Ubiquitin-specific-processing protease 42(gene name synonym)|uniprotkb:Deubiquitinating enzyme 42(gene name synonym)|uniprotkb:Ubiquitin thioesterase 42(gene name synonym) psi-mi:rt31_human(display_long)|uniprotkb:Imogen 38(gene name synonym)|uniprotkb:MRPS31(gene name)|psi-mi:MRPS31(display_short)|uniprotkb:IMOGN38(gene name synonym)|uniprotkb:Mitochondrial small ribosomal subunit protein mS31(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513636|imex:IM-12079-85 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007283"(spermatogenesis)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030154"(cell differentiation)|go:"GO:0042981"(regulation of apoptotic process)|reactome:R-HSA-5689880|interpro:IPR028889|interpro:IPR038765|refseq:NP_115548.1|interpro:IPR018200|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|mint:Q9H9J4 refseq:NP_005821.2|ensembl:ENSG00000102738(gene)|ensembl:ENST00000323563(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005763"(mitochondrial small ribosomal subunit)|go:"GO:0019904"(protein domain specific binding)|interpro:IPR026299|mint:Q92665|rcsb pdb:3J9M|rcsb pdb:6NU2|rcsb pdb:6NU3|rcsb pdb:6RW4|rcsb pdb:6RW5|rcsb pdb:6VLZ|rcsb pdb:6VMI|rcsb pdb:6ZM5|rcsb pdb:6ZM6|rcsb pdb:6ZS9|rcsb pdb:6ZSA|rcsb pdb:6ZSB|rcsb pdb:6ZSC|rcsb pdb:6ZSD|rcsb pdb:6ZSE|rcsb pdb:6ZSG|rcsb pdb:7A5F|rcsb pdb:7A5G|rcsb pdb:7A5I|rcsb pdb:7A5K|rcsb pdb:7L08|rcsb pdb:7OG4|reactome:R-HSA-5368286|reactome:R-HSA-5389840|reactome:R-HSA-5419276 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:kcGXFKKr/9BwysWkDkqi2iUmTCg9606 rogid:Le0Lq+WW56dP5NLuMB2eKFeg6b09606 intact-crc:4E2159AB3827EA15|rigid:g3ZxzXGqanLtXGntmlYvrLvUjac false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H9J4 uniprotkb:O00505 intact:EBI-2513638|uniprotkb:Q6P9B4|uniprotkb:Q3C166|uniprotkb:A2RUE3|uniprotkb:B5MDA5|uniprotkb:Q0VIN8 intact:EBI-358297|intact:EBI-28976892|ensembl:ENSP00000261667|uniprotkb:O00191|uniprotkb:O43195|uniprotkb:Q96AA7|uniprotkb:Q5JVM9|intact:EBI-742146|uniprotkb:Q8IYQ9 psi-mi:ubp42_human(display_long)|uniprotkb:USP42(gene name)|psi-mi:USP42(display_short)|uniprotkb:Ubiquitin-specific-processing protease 42(gene name synonym)|uniprotkb:Deubiquitinating enzyme 42(gene name synonym)|uniprotkb:Ubiquitin thioesterase 42(gene name synonym) psi-mi:ima4_human(display_long)|uniprotkb:KPNA3(gene name)|psi-mi:KPNA3(display_short)|uniprotkb:QIP2(gene name synonym)|uniprotkb:Karyopherin subunit alpha-3(gene name synonym)|uniprotkb:SRP1-gamma(gene name synonym)|uniprotkb:Importin alpha Q2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513636|imex:IM-12079-85 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007283"(spermatogenesis)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030154"(cell differentiation)|go:"GO:0042981"(regulation of apoptotic process)|reactome:R-HSA-5689880|interpro:IPR028889|interpro:IPR038765|refseq:NP_115548.1|interpro:IPR018200|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|mint:Q9H9J4 ensembl:ENSG00000102753(gene)|ensembl:ENST00000261667(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006607"(NLS-bearing protein import into nucleus)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0043657"(host cell)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0061608"(nuclear import signal receptor activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0075732"(viral penetration into host nucleus)|interpro:IPR000225(Armadillo)|refseq:NP_002258.2|ensembl:ENSP00000261667|dip:DIP-27586N|interpro:IPR002652(Importin-alpha-like, importin-beta-binding region)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR024931|interpro:IPR032413|interpro:IPR036975|mint:O00505|reactome:R-HSA-1169408|reactome:R-HSA-168276 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:kcGXFKKr/9BwysWkDkqi2iUmTCg9606 rogid:kx/oTYWMYG7dhwJHvr1POLD6FTU9606 intact-crc:4E2159AB3827EA15|rigid:g3ZxzXGqanLtXGntmlYvrLvUjac false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H9J4 uniprotkb:O43660 intact:EBI-2513638|uniprotkb:Q6P9B4|uniprotkb:Q3C166|uniprotkb:A2RUE3|uniprotkb:B5MDA5|uniprotkb:Q0VIN8 intact:EBI-1051504|uniprotkb:Q3KQY5|uniprotkb:Q8WUD8|uniprotkb:B3KMK4|ensembl:ENSP00000424417 psi-mi:ubp42_human(display_long)|uniprotkb:USP42(gene name)|psi-mi:USP42(display_short)|uniprotkb:Ubiquitin-specific-processing protease 42(gene name synonym)|uniprotkb:Deubiquitinating enzyme 42(gene name synonym)|uniprotkb:Ubiquitin thioesterase 42(gene name synonym) psi-mi:plrg1_human(display_long)|uniprotkb:PLRG1(gene name)|psi-mi:PLRG1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513636|imex:IM-12079-85 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007283"(spermatogenesis)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030154"(cell differentiation)|go:"GO:0042981"(regulation of apoptotic process)|reactome:R-HSA-5689880|interpro:IPR028889|interpro:IPR038765|refseq:NP_115548.1|interpro:IPR018200|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|mint:Q9H9J4 refseq:NP_001188493.1|refseq:NP_002660.1|ensembl:ENSG00000171566(gene)|ensembl:ENST00000499023(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000974"(Prp19 complex)|go:"GO:0001650"(fibrillar center)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0016607"(nuclear speck)|go:"GO:0031965"(nuclear membrane)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0071007"(U2-type catalytic step 2 spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0080008"(Cul4-RING E3 ubiquitin ligase complex)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|mint:O43660|rcsb pdb:4YVD|rcsb pdb:5MQF|rcsb pdb:5XJC|rcsb pdb:5YZG|rcsb pdb:5Z56|rcsb pdb:5Z57|rcsb pdb:5Z58|rcsb pdb:6FF4|rcsb pdb:6FF7|rcsb pdb:6ICZ|rcsb pdb:6ID0|rcsb pdb:6ID1|rcsb pdb:6QDV|rcsb pdb:6ZYM|rcsb pdb:7AAV|rcsb pdb:7ABF|rcsb pdb:7ABG|rcsb pdb:7ABI|rcsb pdb:7DH6|rcsb pdb:7DVQ|reactome:R-HSA-72163|interpro:IPR020472 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:kcGXFKKr/9BwysWkDkqi2iUmTCg9606 rogid:TdZ60+R9eEw7Q0zgsHjv8DImHMA9606 intact-crc:4E2159AB3827EA15|rigid:g3ZxzXGqanLtXGntmlYvrLvUjac false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H0E7 uniprotkb:Q9NP81 intact:EBI-2512823|ensembl:ENSP00000258499|ensembl:ENSP00000376806|ensembl:ENSP00000442629|uniprotkb:B2RDW3 intact:EBI-1049768|uniprotkb:A6NHW7|uniprotkb:Q9BVP3|uniprotkb:B4DE10|ensembl:ENSP00000221431|ensembl:ENSP00000489539 psi-mi:ubp44_human(display_long)|uniprotkb:USP44(gene name)|psi-mi:USP44(display_short)|uniprotkb:Ubiquitin-specific-processing protease 44(gene name synonym)|uniprotkb:Deubiquitinating enzyme 44(gene name synonym)|uniprotkb:Ubiquitin thioesterase 44(gene name synonym) psi-mi:sysm_human(display_long)|uniprotkb:"Seryl-tRNA(Ser/Sec) synthetase"(gene name synonym)|uniprotkb:SerRSmt(gene name synonym)|uniprotkb:SARS2(gene name)|psi-mi:SARS2(display_short)|uniprotkb:SARSM(gene name synonym)|uniprotkb:Seryl-tRNA synthetase(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513724|imex:IM-12079-35 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000136014(gene)|ensembl:ENST00000258499(transcript)|ensembl:ENST00000393091(transcript)|ensembl:ENST00000537435(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0007049"(cell cycle)|go:"GO:0007059"(chromosome segregation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0051301"(cell division)|go:"GO:0090266"(regulation of mitotic cell cycle spindle assembly checkpoint)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|reactome:R-HSA-5689880|refseq:NP_001035862.1|refseq:NP_115523.2|refseq:NP_001334865.1|refseq:NP_001334866.1|refseq:NP_001265322.1|refseq:XP_016875499.1 refseq:NP_001139373.1|refseq:NP_060297.1|interpro:IPR002317(Seryl-tRNA synthetase, class IIa)|interpro:IPR006195(Aminoacyl-tRNA synthetase, class II)|interpro:IPR010978(tRNA-binding arm)|interpro:IPR033729|interpro:IPR042103|mint:Q9NP81|interpro:IPR002314("Aminoacyl-tRNA synthetase, class II (G, H, P and S)")|reactome:R-HSA-379726|ensembl:ENSG00000104835(gene)|ensembl:ENSG00000283104(gene)|ensembl:ENST00000221431(transcript)|ensembl:ENST00000634687(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004828"(serine-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006434"(seryl-tRNA aminoacylation)|go:"GO:0070158"(mitochondrial seryl-tRNA aminoacylation)|go:"GO:0097056"("selenocysteinyl-tRNA(Sec) biosynthetic process") psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:bLj1vAKvdLEl+jd7n9MMCOKBtco9606 rogid:xYa2ZQIifKicNHV/6vlcUGaN9q49606 intact-crc:E6C24BC725912CCE|rigid:3iT9leqYT9hib3z/VvMBNMH0zTM false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H0E7 uniprotkb:Q13428 intact:EBI-2512823|ensembl:ENSP00000258499|ensembl:ENSP00000376806|ensembl:ENSP00000442629|uniprotkb:B2RDW3 intact:EBI-396105|uniprotkb:Q6SC72|uniprotkb:Q7Z5W9|uniprotkb:Q96A52|uniprotkb:Q99408|uniprotkb:Q99860|uniprotkb:A0JLU0|uniprotkb:B4E111|intact:EBI-28974716|ensembl:ENSP00000367028|ensembl:ENSP00000421655 psi-mi:ubp44_human(display_long)|uniprotkb:USP44(gene name)|psi-mi:USP44(display_short)|uniprotkb:Ubiquitin-specific-processing protease 44(gene name synonym)|uniprotkb:Deubiquitinating enzyme 44(gene name synonym)|uniprotkb:Ubiquitin thioesterase 44(gene name synonym) psi-mi:tcof_human(display_long)|uniprotkb:TCOF1(gene name)|psi-mi:TCOF1(display_short)|uniprotkb:Treacher Collins syndrome protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513724|imex:IM-12079-35 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000136014(gene)|ensembl:ENST00000258499(transcript)|ensembl:ENST00000393091(transcript)|ensembl:ENST00000537435(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0007049"(cell cycle)|go:"GO:0007059"(chromosome segregation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0051301"(cell division)|go:"GO:0090266"(regulation of mitotic cell cycle spindle assembly checkpoint)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|reactome:R-HSA-5689880|refseq:NP_001035862.1|refseq:NP_115523.2|refseq:NP_001334865.1|refseq:NP_001334866.1|refseq:NP_001265322.1|refseq:XP_016875499.1 refseq:NP_000347.2|refseq:NP_001008657.1|refseq:NP_001128715.1|refseq:NP_001128716.1|refseq:NP_001128717.1|refseq:NP_001182070.1|ensembl:ENST00000323668|ensembl:ENSP00000325223|ensembl:ENSP00000367028|ensembl:ENST00000394269|ensembl:ENSP00000377811|ensembl:ENST00000427724|ensembl:ENSP00000390717|ensembl:ENST00000439160|ensembl:ENSP00000406888|ensembl:ENST00000445265|ensembl:ENSP00000409944|ensembl:ENSP00000421655|ensembl:ENST00000643257|ensembl:ENSP00000493815|refseq:XP_005268562.1|ensembl:ENSG00000070814(gene)|ensembl:ENST00000377797(transcript)|ensembl:ENST00000504761(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0005215"(transporter activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006417"(regulation of translation)|go:"GO:0014029"(neural crest formation)|go:"GO:0014032"(neural crest cell development)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0042790"(nucleolar large rRNA transcription by RNA polymerase I)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0097110"(scaffold protein binding)|interpro:IPR003993(Treacher Collins syndrome, treacle)|interpro:IPR006594(LisH dimerisation motif)|interpro:IPR017859|mint:Q13428|dip:DIP-32953N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:bLj1vAKvdLEl+jd7n9MMCOKBtco9606 rogid:eRazgHpn5CwQVFH5hRnA/sVp24M9606 intact-crc:E6C24BC725912CCE|rigid:3iT9leqYT9hib3z/VvMBNMH0zTM false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H0E7 uniprotkb:Q96EL3 intact:EBI-2512823|ensembl:ENSP00000258499|ensembl:ENSP00000376806|ensembl:ENSP00000442629|uniprotkb:B2RDW3 intact:EBI-2513715|ensembl:ENSP00000258105 psi-mi:ubp44_human(display_long)|uniprotkb:USP44(gene name)|psi-mi:USP44(display_short)|uniprotkb:Ubiquitin-specific-processing protease 44(gene name synonym)|uniprotkb:Deubiquitinating enzyme 44(gene name synonym)|uniprotkb:Ubiquitin thioesterase 44(gene name synonym) psi-mi:rm53_human(display_long)|uniprotkb:MRPL53(gene name)|psi-mi:MRPL53(display_short)|uniprotkb:Mitochondrial large ribosomal subunit protein mL53(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513724|imex:IM-12079-35 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000136014(gene)|ensembl:ENST00000258499(transcript)|ensembl:ENST00000393091(transcript)|ensembl:ENST00000537435(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0007049"(cell cycle)|go:"GO:0007059"(chromosome segregation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0051301"(cell division)|go:"GO:0090266"(regulation of mitotic cell cycle spindle assembly checkpoint)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|reactome:R-HSA-5689880|refseq:NP_001035862.1|refseq:NP_115523.2|refseq:NP_001334865.1|refseq:NP_001334866.1|refseq:NP_001265322.1|refseq:XP_016875499.1 ensembl:ENSG00000204822(gene)|ensembl:ENST00000258105(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005762"(mitochondrial large ribosomal subunit)|interpro:IPR019716|rcsb pdb:3J7Y|rcsb pdb:3J9M|rcsb pdb:5OOL|rcsb pdb:5OOM|rcsb pdb:6I9R|rcsb pdb:6NU2|rcsb pdb:6NU3|rcsb pdb:6VLZ|rcsb pdb:6VMI|rcsb pdb:6ZM5|rcsb pdb:6ZM6|rcsb pdb:6ZS9|rcsb pdb:6ZSA|rcsb pdb:6ZSB|rcsb pdb:6ZSC|rcsb pdb:6ZSD|rcsb pdb:6ZSE|rcsb pdb:6ZSG|rcsb pdb:7A5F|rcsb pdb:7A5G|rcsb pdb:7A5H|rcsb pdb:7A5I|rcsb pdb:7A5K|rcsb pdb:7L08|rcsb pdb:7L20|rcsb pdb:7O9K|rcsb pdb:7O9M|rcsb pdb:7ODR|rcsb pdb:7ODS|rcsb pdb:7ODT|rcsb pdb:7OF0|rcsb pdb:7OF2|rcsb pdb:7OF3|rcsb pdb:7OF4|rcsb pdb:7OF5|rcsb pdb:7OF6|rcsb pdb:7OF7|rcsb pdb:7OG4|reactome:R-HSA-5368286|reactome:R-HSA-5389840|reactome:R-HSA-5419276|rcsb pdb:7A5J|refseq:NP_444278.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:bLj1vAKvdLEl+jd7n9MMCOKBtco9606 rogid:+P6xCKwzJVVQv/StyLhlLH9NkgA9606 intact-crc:E6C24BC725912CCE|rigid:3iT9leqYT9hib3z/VvMBNMH0zTM false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H0E7 uniprotkb:P82921 intact:EBI-2512823|ensembl:ENSP00000258499|ensembl:ENSP00000376806|ensembl:ENSP00000442629|uniprotkb:B2RDW3 intact:EBI-2372155|uniprotkb:Q9BST6|uniprotkb:A0A075B746|uniprotkb:Q5TB11|ensembl:ENSP00000461930|ensembl:ENSP00000480129 psi-mi:ubp44_human(display_long)|uniprotkb:USP44(gene name)|psi-mi:USP44(display_short)|uniprotkb:Ubiquitin-specific-processing protease 44(gene name synonym)|uniprotkb:Deubiquitinating enzyme 44(gene name synonym)|uniprotkb:Ubiquitin thioesterase 44(gene name synonym) psi-mi:rt21_human(display_long)|uniprotkb:MRPS21(gene name)|psi-mi:MRPS21(display_short)|uniprotkb:RPMS21(gene name synonym)|uniprotkb:MDS016(orf name)|uniprotkb:Mitochondrial small ribosomal subunit protein bS21m(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513724|imex:IM-12079-35 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000136014(gene)|ensembl:ENST00000258499(transcript)|ensembl:ENST00000393091(transcript)|ensembl:ENST00000537435(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0007049"(cell cycle)|go:"GO:0007059"(chromosome segregation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0051301"(cell division)|go:"GO:0090266"(regulation of mitotic cell cycle spindle assembly checkpoint)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|reactome:R-HSA-5689880|refseq:NP_001035862.1|refseq:NP_115523.2|refseq:NP_001334865.1|refseq:NP_001334866.1|refseq:NP_001265322.1|refseq:XP_016875499.1 refseq:NP_061870.1|refseq:NP_114107.1|ensembl:ENSG00000266472(gene)|ensembl:ENST00000581066(transcript)|ensembl:ENST00000614145(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005763"(mitochondrial small ribosomal subunit)|go:"GO:0006412"(translation)|go:"GO:0032543"(mitochondrial translation)|interpro:IPR001911(Ribosomal protein S21)|interpro:IPR038380|mint:P82921|rcsb pdb:3J9M|rcsb pdb:6NU2|rcsb pdb:6NU3|rcsb pdb:6RW4|rcsb pdb:6RW5|rcsb pdb:6VLZ|rcsb pdb:6VMI|rcsb pdb:6ZM5|rcsb pdb:6ZM6|rcsb pdb:6ZS9|rcsb pdb:6ZSA|rcsb pdb:6ZSB|rcsb pdb:6ZSC|rcsb pdb:6ZSE|rcsb pdb:6ZSG|rcsb pdb:7A5F|rcsb pdb:7A5G|rcsb pdb:7A5I|rcsb pdb:7A5K|rcsb pdb:7L08|rcsb pdb:7OG4|reactome:R-HSA-5368286|reactome:R-HSA-5389840|reactome:R-HSA-5419276 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:bLj1vAKvdLEl+jd7n9MMCOKBtco9606 rogid:AGyHmum6PLo+BxY+wgQvG2894A49606 intact-crc:E6C24BC725912CCE|rigid:3iT9leqYT9hib3z/VvMBNMH0zTM false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H0E7 uniprotkb:Q9Y4P3 intact:EBI-2512823|ensembl:ENSP00000258499|ensembl:ENSP00000376806|ensembl:ENSP00000442629|uniprotkb:B2RDW3 intact:EBI-2513719|ensembl:ENSP00000307260|uniprotkb:Q9UQE2 psi-mi:ubp44_human(display_long)|uniprotkb:USP44(gene name)|psi-mi:USP44(display_short)|uniprotkb:Ubiquitin-specific-processing protease 44(gene name synonym)|uniprotkb:Deubiquitinating enzyme 44(gene name synonym)|uniprotkb:Ubiquitin thioesterase 44(gene name synonym) psi-mi:tbl2_human(display_long)|uniprotkb:TBL2(gene name)|psi-mi:TBL2(display_short)|uniprotkb:WBSCR13(gene name synonym)|uniprotkb:WS beta-transducin repeats protein(gene name synonym)|uniprotkb:Williams-Beuren syndrome chromosomal region 13 protein(gene name synonym)|uniprotkb:UNQ563/PRO1125(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513724|imex:IM-12079-35 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000136014(gene)|ensembl:ENST00000258499(transcript)|ensembl:ENST00000393091(transcript)|ensembl:ENST00000537435(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0007049"(cell cycle)|go:"GO:0007059"(chromosome segregation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0051301"(cell division)|go:"GO:0090266"(regulation of mitotic cell cycle spindle assembly checkpoint)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|reactome:R-HSA-5689880|refseq:NP_001035862.1|refseq:NP_115523.2|refseq:NP_001334865.1|refseq:NP_001334866.1|refseq:NP_001265322.1|refseq:XP_016875499.1 ensembl:ENSG00000106638(gene)|ensembl:ENST00000305632(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0071456"(cellular response to hypoxia)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR020472|interpro:IPR036322|interpro:IPR042410|mint:Q9Y4P3|refseq:NP_036585.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:bLj1vAKvdLEl+jd7n9MMCOKBtco9606 rogid:K0mFwM08LEIAWO/zg4Irplaq9oM9606 intact-crc:E6C24BC725912CCE|rigid:3iT9leqYT9hib3z/VvMBNMH0zTM false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H0E7 uniprotkb:P41208 intact:EBI-2512823|ensembl:ENSP00000258499|ensembl:ENSP00000376806|ensembl:ENSP00000442629|uniprotkb:B2RDW3 intact:EBI-1789926|uniprotkb:Q53XW1|uniprotkb:B2R4T4|ensembl:ENSP00000359300 psi-mi:ubp44_human(display_long)|uniprotkb:USP44(gene name)|psi-mi:USP44(display_short)|uniprotkb:Ubiquitin-specific-processing protease 44(gene name synonym)|uniprotkb:Deubiquitinating enzyme 44(gene name synonym)|uniprotkb:Ubiquitin thioesterase 44(gene name synonym) psi-mi:cetn2_human(display_long)|uniprotkb:CETN2(gene name)|psi-mi:CETN2(display_short)|uniprotkb:CALT(gene name synonym)|uniprotkb:CEN2(gene name synonym)|uniprotkb:Caltractin isoform 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513724|imex:IM-12079-35 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000136014(gene)|ensembl:ENST00000258499(transcript)|ensembl:ENST00000393091(transcript)|ensembl:ENST00000537435(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0007049"(cell cycle)|go:"GO:0007059"(chromosome segregation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0051301"(cell division)|go:"GO:0090266"(regulation of mitotic cell cycle spindle assembly checkpoint)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|reactome:R-HSA-5689880|refseq:NP_001035862.1|refseq:NP_115523.2|refseq:NP_001334865.1|refseq:NP_001334866.1|refseq:NP_001265322.1|refseq:XP_016875499.1 refseq:NP_004335.1|ensembl:ENSG00000147400(gene)|ensembl:ENST00000370277(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0007099"(centriole replication)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008017"(microtubule binding)|go:"GO:0015031"(protein transport)|go:"GO:0031683"(G-protein beta/gamma-subunit complex binding)|go:"GO:0032391"(photoreceptor connecting cilium)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032795"(heterotrimeric G-protein binding)|go:"GO:0036064"(ciliary basal body)|go:"GO:0044615"(nuclear pore nuclear basket)|go:"GO:0045177"(apical part of cell)|go:"GO:0051028"(mRNA transport)|go:"GO:0051301"(cell division)|go:"GO:0070390"(transcription export complex 2)|go:"GO:0071942"(XPC complex)|go:"GO:0097729"(9+2 motile cilium)|interpro:IPR000629(RNA helicase, ATP-dependent, DEAD-box, conserved site)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR037629|rcsb pdb:1M39|rcsb pdb:1ZMZ|rcsb pdb:2A4J|rcsb pdb:2GGM|rcsb pdb:2K2I|rcsb pdb:2OBH|reactome:R-HSA-2565942|reactome:R-HSA-3108214|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-5696394|reactome:R-HSA-5696395|reactome:R-HSA-8854518 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:bLj1vAKvdLEl+jd7n9MMCOKBtco9606 rogid:gOH/cxPm4HW7g94+UYIAAipqXyg9606 intact-crc:E6C24BC725912CCE|rigid:3iT9leqYT9hib3z/VvMBNMH0zTM false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H0E7 uniprotkb:Q13601 intact:EBI-2512823|ensembl:ENSP00000258499|ensembl:ENSP00000376806|ensembl:ENSP00000442629|uniprotkb:B2RDW3 intact:EBI-744525|intact:EBI-28971604|ensembl:ENSP00000229214|uniprotkb:Q8NEA8|uniprotkb:Q8TC37|uniprotkb:Q96AT5|uniprotkb:A0FIK6|uniprotkb:A0JLP0|uniprotkb:B2R989|uniprotkb:E7EUQ0 psi-mi:ubp44_human(display_long)|uniprotkb:USP44(gene name)|psi-mi:USP44(display_short)|uniprotkb:Ubiquitin-specific-processing protease 44(gene name synonym)|uniprotkb:Deubiquitinating enzyme 44(gene name synonym)|uniprotkb:Ubiquitin thioesterase 44(gene name synonym) psi-mi:krr1_human(display_long)|uniprotkb:HIV-1 Rev-binding protein 2(gene name synonym)|uniprotkb:Rev-interacting protein 1(gene name synonym)|uniprotkb:KRR1(gene name)|psi-mi:KRR1(display_short)|uniprotkb:HRB2(gene name synonym)|uniprotkb:KRR-R motif-containing protein 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513724|imex:IM-12079-35 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000136014(gene)|ensembl:ENST00000258499(transcript)|ensembl:ENST00000393091(transcript)|ensembl:ENST00000537435(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0007049"(cell cycle)|go:"GO:0007059"(chromosome segregation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0051301"(cell division)|go:"GO:0090266"(regulation of mitotic cell cycle spindle assembly checkpoint)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|reactome:R-HSA-5689880|refseq:NP_001035862.1|refseq:NP_115523.2|refseq:NP_001334865.1|refseq:NP_001334866.1|refseq:NP_001265322.1|refseq:XP_016875499.1 ensembl:ENSP00000229214|ensembl:ENST00000438169|ensembl:ENSP00000411740|ensembl:ENSG00000111615(gene)|ensembl:ENST00000229214(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006364"(rRNA processing)|go:"GO:0016020"(membrane)|go:"GO:0032040"(small-subunit processome)|go:"GO:0045171"(intercellular bridge)|interpro:IPR004087(K Homology)|interpro:IPR024166|interpro:IPR036612|interpro:IPR041174|mint:Q13601|refseq:NP_008974.5|reactome:R-HSA-6790901|reactome:R-HSA-6791226 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:bLj1vAKvdLEl+jd7n9MMCOKBtco9606 rogid:uBKNL/aw4wEssKJulbqQVWcH7ZI9606 intact-crc:E6C24BC725912CCE|rigid:3iT9leqYT9hib3z/VvMBNMH0zTM false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H0E7 uniprotkb:Q9NQ50 intact:EBI-2512823|ensembl:ENSP00000258499|ensembl:ENSP00000376806|ensembl:ENSP00000442629|uniprotkb:B2RDW3 intact:EBI-1053902|uniprotkb:O95134|ensembl:ENSP00000333401|uniprotkb:B3KVZ7 psi-mi:ubp44_human(display_long)|uniprotkb:USP44(gene name)|psi-mi:USP44(display_short)|uniprotkb:Ubiquitin-specific-processing protease 44(gene name synonym)|uniprotkb:Deubiquitinating enzyme 44(gene name synonym)|uniprotkb:Ubiquitin thioesterase 44(gene name synonym) psi-mi:rm40_human(display_long)|uniprotkb:Nuclear localization signal-containing protein deleted in velocardiofacial syndrome(gene name synonym)|uniprotkb:Up-regulated in metastasis(gene name synonym)|uniprotkb:MRPL40(gene name)|psi-mi:MRPL40(display_short)|uniprotkb:NLVCF(gene name synonym)|uniprotkb:URIM(gene name synonym)|uniprotkb:Mitochondrial large ribosomal subunit protein mL40(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513724|imex:IM-12079-35 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000136014(gene)|ensembl:ENST00000258499(transcript)|ensembl:ENST00000393091(transcript)|ensembl:ENST00000537435(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0007049"(cell cycle)|go:"GO:0007059"(chromosome segregation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0051301"(cell division)|go:"GO:0090266"(regulation of mitotic cell cycle spindle assembly checkpoint)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|reactome:R-HSA-5689880|refseq:NP_001035862.1|refseq:NP_115523.2|refseq:NP_001334865.1|refseq:NP_001334866.1|refseq:NP_001265322.1|refseq:XP_016875499.1 ensembl:ENSG00000185608(gene)|ensembl:ENST00000333130(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005761"(mitochondrial ribosome)|go:"GO:0005762"(mitochondrial large ribosomal subunit)|go:"GO:0009653"(anatomical structure morphogenesis)|interpro:IPR019192|interpro:IPR039145|rcsb pdb:3J7Y|rcsb pdb:3J9M|rcsb pdb:5OOL|rcsb pdb:5OOM|rcsb pdb:6I9R|rcsb pdb:6NU2|rcsb pdb:6NU3|refseq:NP_003767.2|rcsb pdb:6VLZ|rcsb pdb:6VMI|rcsb pdb:6ZM5|rcsb pdb:6ZM6|rcsb pdb:6ZS9|rcsb pdb:6ZSA|rcsb pdb:6ZSB|rcsb pdb:6ZSC|rcsb pdb:6ZSD|rcsb pdb:6ZSE|rcsb pdb:7A5F|rcsb pdb:7A5G|rcsb pdb:7A5H|rcsb pdb:7A5I|rcsb pdb:7A5J|rcsb pdb:7A5K|rcsb pdb:7L08|rcsb pdb:7L20|rcsb pdb:7O9K|rcsb pdb:7O9M|rcsb pdb:7ODR|rcsb pdb:7ODS|rcsb pdb:7ODT|rcsb pdb:7OF0|rcsb pdb:7OF2|rcsb pdb:7OF3|rcsb pdb:7OF4|rcsb pdb:7OF5|rcsb pdb:7OF6|rcsb pdb:7OF7|rcsb pdb:7OG4|reactome:R-HSA-5368286|rcsb pdb:6ZSG|reactome:R-HSA-5389840|reactome:R-HSA-5419276 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:bLj1vAKvdLEl+jd7n9MMCOKBtco9606 rogid:1puL0njSb72Xpg43i1ZEAL/l8DU9606 intact-crc:E6C24BC725912CCE|rigid:3iT9leqYT9hib3z/VvMBNMH0zTM false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H0E7 uniprotkb:Q16540 intact:EBI-2512823|ensembl:ENSP00000258499|ensembl:ENSP00000376806|ensembl:ENSP00000442629|uniprotkb:B2RDW3 intact:EBI-1046141|uniprotkb:A8MT29|uniprotkb:Q96Q71|ensembl:ENSP00000370930|ensembl:ENSP00000380466|ensembl:ENSP00000500123|ensembl:ENSP00000500896 psi-mi:ubp44_human(display_long)|uniprotkb:USP44(gene name)|psi-mi:USP44(display_short)|uniprotkb:Ubiquitin-specific-processing protease 44(gene name synonym)|uniprotkb:Deubiquitinating enzyme 44(gene name synonym)|uniprotkb:Ubiquitin thioesterase 44(gene name synonym) psi-mi:rm23_human(display_long)|uniprotkb:L23 mitochondrial-related protein(gene name synonym)|uniprotkb:Ribosomal protein L23-like(gene name synonym)|uniprotkb:L23MRP(gene name synonym)|uniprotkb:RPL23L(gene name synonym)|uniprotkb:MRPL23(gene name)|psi-mi:MRPL23(display_short)|uniprotkb:Mitochondrial large ribosomal subunit protein uL23m(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513724|imex:IM-12079-35 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000136014(gene)|ensembl:ENST00000258499(transcript)|ensembl:ENST00000393091(transcript)|ensembl:ENST00000537435(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0007049"(cell cycle)|go:"GO:0007059"(chromosome segregation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0051301"(cell division)|go:"GO:0090266"(regulation of mitotic cell cycle spindle assembly checkpoint)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|reactome:R-HSA-5689880|refseq:NP_001035862.1|refseq:NP_115523.2|refseq:NP_001334865.1|refseq:NP_001334866.1|refseq:NP_001265322.1|refseq:XP_016875499.1 refseq:NP_066957.3|ensembl:ENSG00000214026(gene)|ensembl:ENSG00000288141(gene)|ensembl:ENST00000381519(transcript)|ensembl:ENST00000397298(transcript)|rcsb pdb:6ZSG|rcsb pdb:7A5F|rcsb pdb:7A5G|rcsb pdb:7A5H|rcsb pdb:7A5I|rcsb pdb:7A5J|rcsb pdb:7A5K|rcsb pdb:7L08|rcsb pdb:7L20|rcsb pdb:7O9K|rcsb pdb:7O9M|rcsb pdb:7ODR|ensembl:ENST00000672185(transcript)|ensembl:ENST00000672523(transcript)|go:"GO:0001650"(fibrillar center)|rcsb pdb:7ODS|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005762"(mitochondrial large ribosomal subunit)|go:"GO:0006412"(translation)|go:"GO:0032543"(mitochondrial translation)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR012678(Ribosomal protein L23/L15e, core)|interpro:IPR013025(Ribosomal protein L25/L23)|mint:Q16540|rcsb pdb:3J7Y|rcsb pdb:3J9M|rcsb pdb:5OOL|rcsb pdb:5OOM|rcsb pdb:6I9R|rcsb pdb:6NU2|rcsb pdb:6NU3|rcsb pdb:6VLZ|rcsb pdb:6VMI|rcsb pdb:6ZM5|rcsb pdb:6ZM6|rcsb pdb:6ZS9|rcsb pdb:6ZSA|rcsb pdb:6ZSB|rcsb pdb:6ZSC|rcsb pdb:6ZSD|rcsb pdb:6ZSE|rcsb pdb:7ODT|rcsb pdb:7OF2|rcsb pdb:7OF3|rcsb pdb:7OF4|rcsb pdb:7OF5|rcsb pdb:7OF6|rcsb pdb:7OF7|rcsb pdb:7OG4|reactome:R-HSA-5368286|reactome:R-HSA-5389840|reactome:R-HSA-5419276|rcsb pdb:7OF0 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:bLj1vAKvdLEl+jd7n9MMCOKBtco9606 rogid:1TSlowXDlWVOW2PS1vv8Lu/e1vU9606 intact-crc:E6C24BC725912CCE|rigid:3iT9leqYT9hib3z/VvMBNMH0zTM false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9H0E7 uniprotkb:P62487 intact:EBI-2512823|ensembl:ENSP00000258499|ensembl:ENSP00000376806|ensembl:ENSP00000442629|uniprotkb:B2RDW3 intact:EBI-347928|ensembl:ENSP00000301788|uniprotkb:P52433|uniprotkb:Q2M1Z4|uniprotkb:B2R5C0 psi-mi:ubp44_human(display_long)|uniprotkb:USP44(gene name)|psi-mi:USP44(display_short)|uniprotkb:Ubiquitin-specific-processing protease 44(gene name synonym)|uniprotkb:Deubiquitinating enzyme 44(gene name synonym)|uniprotkb:Ubiquitin thioesterase 44(gene name synonym) psi-mi:rpb7_human(display_long)|uniprotkb:POLR2G(gene name)|psi-mi:POLR2G(display_short)|uniprotkb:DNA-directed RNA polymerase II subunit G(gene name synonym)|uniprotkb:RPB7(gene name synonym)|uniprotkb:RNA polymerase II 19 kDa subunit(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513724|imex:IM-12079-35 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000136014(gene)|ensembl:ENST00000258499(transcript)|ensembl:ENST00000393091(transcript)|ensembl:ENST00000537435(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0007049"(cell cycle)|go:"GO:0007059"(chromosome segregation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0051301"(cell division)|go:"GO:0090266"(regulation of mitotic cell cycle spindle assembly checkpoint)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|reactome:R-HSA-5689880|refseq:NP_001035862.1|refseq:NP_115523.2|refseq:NP_001334865.1|refseq:NP_001334866.1|refseq:NP_001265322.1|refseq:XP_016875499.1 ensembl:ENSG00000168002(gene)|ensembl:ENST00000301788(transcript)|go:"GO:0000291"(nuclear-transcribed mRNA catabolic process, exonucleolytic)|go:"GO:0000932"(P-body)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003899"(DNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005665"(RNA polymerase II, core complex)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0006915"(apoptotic process)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0060213"("positive regulation of nuclear-transcribed mRNA poly(A) tail shortening")|interpro:IPR003029(S1, RNA binding)|interpro:IPR005576(RNA polymerase Rpb7, N-terminal)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR022967|interpro:IPR036898|mint:P62487|rcsb pdb:2C35|rcsb pdb:5IYA|rcsb pdb:5IY6|rcsb pdb:5IYB|rcsb pdb:5IYC|rcsb pdb:5IYD|rcsb pdb:6DRD|rcsb pdb:6O9L|rcsb pdb:6XRE|rcsb pdb:7LBM|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167160|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|rcsb pdb:5IY7|reactome:R-HSA-167200|reactome:R-HSA-167238|rcsb pdb:5IY8|rcsb pdb:5IY9|reactome:R-HSA-167242|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-168325|reactome:R-HSA-203927|reactome:R-HSA-5578749|reactome:R-HSA-5617472|reactome:R-HSA-674695|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6796648|reactome:R-HSA-6803529|reactome:R-HSA-6807505|reactome:R-HSA-72086|reactome:R-HSA-72163|reactome:R-HSA-72165|reactome:R-HSA-72203|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-5601884|reactome:R-HSA-75953|reactome:R-HSA-75955|reactome:R-HSA-76042|reactome:R-HSA-77075|reactome:R-HSA-8851708|reactome:R-HSA-9018519|reactome:R-HSA-9670095|refseq:NP_002687.1|dip:DIP-32663N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:bLj1vAKvdLEl+jd7n9MMCOKBtco9606 rogid:MtnIweuhSqLFov0c40uOiwv8Eas9606 intact-crc:E6C24BC725912CCE|rigid:3iT9leqYT9hib3z/VvMBNMH0zTM false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q70EL2 uniprotkb:O14950 intact:EBI-2513758|ensembl:ENSP00000333376|ensembl:ENSP00000424372|uniprotkb:Q9BRU1|uniprotkb:Q86T44|uniprotkb:B2RXG0|uniprotkb:Q5T062|uniprotkb:Q86TC0 intact:EBI-1642165|uniprotkb:D3DUH6|intact:EBI-2826593|uniprotkb:Q7Z5Z4|uniprotkb:Q13182|ensembl:ENSP00000237500|ensembl:ENSP00000383037|ensembl:ENSP00000463559|ensembl:ENSP00000464464|ensembl:ENSP00000496809 psi-mi:ubp45_human(display_long)|uniprotkb:USP45(gene name)|psi-mi:USP45(display_short)|uniprotkb:Ubiquitin-specific-processing protease 45(gene name synonym)|uniprotkb:Deubiquitinating enzyme 45(gene name synonym)|uniprotkb:Ubiquitin thioesterase 45(gene name synonym) psi-mi:ml12b_human(display_long)|uniprotkb:MYL12B(gene name)|psi-mi:MYL12B(display_short)|uniprotkb:MRLC2(gene name synonym)|uniprotkb:Myosin regulatory light chain 2-B, smooth muscle isoform(gene name synonym)|uniprotkb:MLC-2A(gene name synonym)|uniprotkb:SHUJUN-1(gene name synonym)|uniprotkb:MYLC2B(gene name synonym)|uniprotkb:Myosin regulatory light chain MRLC2(gene name synonym)|uniprotkb:Myosin regulatory light chain 20 kDa(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513752|imex:IM-12079-86 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000123552(gene)|ensembl:ENST00000327681(transcript)|ensembl:ENST00000500704(transcript)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0003407"(neural retina development)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016477"(cell migration)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0070911"(global genome nucleotide-excision repair)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|reactome:R-HSA-5696395|refseq:NP_001073950.1|refseq:NP_001332950.1|refseq:NP_001332951.1|refseq:XP_005267227.1 refseq:NP_001138416.1|refseq:NP_001138417.1|refseq:NP_291024.1|refseq:NP_001289978.1|ensembl:ENSG00000118680(gene)|ensembl:ENST00000237500(transcript)|ensembl:ENST00000400175(transcript)|ensembl:ENST00000581193(transcript)|ensembl:ENST00000584539(transcript)|ensembl:ENST00000648965(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005829"(cytosol)|go:"GO:0005903"(brush border)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016460"(myosin II complex)|go:"GO:0030018"(Z disc)|go:"GO:0032036"(myosin heavy chain binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0070062"(extracellular exosome)|go:"GO:0099738"(cell cortex region)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR015070(Region of unknown function DUF1880)|interpro:IPR018247|mint:O14950|reactome:R-HSA-3928663|reactome:R-HSA-416572|reactome:R-HSA-445355|reactome:R-HSA-5625740|reactome:R-HSA-5625900|reactome:R-HSA-5627117|reactome:R-HSA-5627123 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:YA4AjFFI6z2m8AvdkzVdTFDvwvI9606 rogid:5jOP3J5TW0eU9zwalQ2S4Oist4k9606 intact-crc:E407109333184CCF|rigid:jmxo2EO7D7NlpVzSgQfc/ilgjrE false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q70EL2 uniprotkb:P35579 intact:EBI-2513758|ensembl:ENSP00000333376|ensembl:ENSP00000424372|uniprotkb:Q9BRU1|uniprotkb:Q86T44|uniprotkb:B2RXG0|uniprotkb:Q5T062|uniprotkb:Q86TC0 intact:EBI-350338|uniprotkb:O60805|ensembl:ENSP00000216181|uniprotkb:Q86T83|intact:EBI-1054343|uniprotkb:A8K6E4|uniprotkb:Q60FE2 psi-mi:ubp45_human(display_long)|uniprotkb:USP45(gene name)|psi-mi:USP45(display_short)|uniprotkb:Ubiquitin-specific-processing protease 45(gene name synonym)|uniprotkb:Deubiquitinating enzyme 45(gene name synonym)|uniprotkb:Ubiquitin thioesterase 45(gene name synonym) psi-mi:myh9_human(display_long)|uniprotkb:MYH9(gene name)|psi-mi:MYH9(display_short)|uniprotkb:Myosin heavy chain 9(gene name synonym)|uniprotkb:Myosin heavy chain, non-muscle IIa(gene name synonym)|uniprotkb:Non-muscle myosin heavy chain IIa(gene name synonym)|uniprotkb:Cellular myosin heavy chain, type A(gene name synonym)|uniprotkb:Non-muscle myosin heavy chain A(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513752|imex:IM-12079-86 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000123552(gene)|ensembl:ENST00000327681(transcript)|ensembl:ENST00000500704(transcript)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0003407"(neural retina development)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016477"(cell migration)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0070911"(global genome nucleotide-excision repair)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|reactome:R-HSA-5696395|refseq:NP_001073950.1|refseq:NP_001332950.1|refseq:NP_001332951.1|refseq:XP_005267227.1 refseq:NP_002464.1|ensembl:ENSG00000100345(gene)|ensembl:ENST00000216181(transcript)|go:"GO:0000146"(microfilament motor activity)|go:"GO:0000212"(meiotic spindle organization)|go:"GO:0001525"(angiogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001725"(stress fiber)|go:"GO:0001726"(ruffle)|go:"GO:0001768"(establishment of T cell polarity)|go:"GO:0001772"(immunological synapse)|go:"GO:0001778"(plasma membrane repair)|go:"GO:0001931"(uropod)|go:"GO:0003723"(RNA binding)|go:"GO:0003774"(cytoskeletal motor activity)|go:"GO:0003779"(actin binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005826"(actomyosin contractile ring)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007520"(myoblast fusion)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0015031"(protein transport)|refseq:XP_011528499.1|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016460"(myosin II complex)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0030220"(platelet formation)|go:"GO:0030224"(monocyte differentiation)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0031252"(cell leading edge)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032418"(lysosome localization)|go:"GO:0032506"(cytokinetic process)|go:"GO:0032796"(uropod organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0043531"(ADP binding)|go:"GO:0043534"(blood vessel endothelial cell migration)|go:"GO:0045055"(regulated exocytosis)|go:"GO:0045296"(cadherin binding)|go:"GO:0050900"(leukocyte migration)|go:"GO:0051015"(actin filament binding)|go:"GO:0051295"(establishment of meiotic spindle localization)|go:"GO:0060471"(cortical granule exocytosis)|go:"GO:0060473"(cortical granule)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:0097513"(myosin II filament)|go:"GO:1903919"(negative regulation of actin filament severing)|rcsb pdb:4CFR|rcsb pdb:4ETO|reactome:R-HSA-1445148|reactome:R-HSA-2029482|reactome:R-HSA-3928663|reactome:R-HSA-416572|reactome:R-HSA-5625740|reactome:R-HSA-5625900|reactome:R-HSA-5627117|reactome:R-HSA-5627123|reactome:R-HSA-9662360|reactome:R-HSA-9662361|reactome:R-HSA-9662834|reactome:R-HSA-9664422|go:"GO:1903923"(positive regulation of protein processing in phagocytic vesicle)|go:"GO:1905684"(regulation of plasma membrane repair)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR001609(Myosin head, motor region)|interpro:IPR002928(Myosin tail)|interpro:IPR004009(Myosin, N-terminal, SH3-like)|interpro:IPR008989(Myosin S1 fragment, N-terminal)|interpro:IPR027417|interpro:IPR036305|interpro:IPR036961|mint:P35579|rcsb pdb:2LNK|rcsb pdb:3ZWH|rcsb pdb:4CFQ|refseq:XP_016884292.1|refseq:XP_016884293.1|refseq:XP_016884294.1|refseq:XP_016884295.1|dip:DIP-33103N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:YA4AjFFI6z2m8AvdkzVdTFDvwvI9606 rogid:fSOtpFpr8PSnAG5UdAr/khwkzJs9606 intact-crc:E407109333184CCF|rigid:jmxo2EO7D7NlpVzSgQfc/ilgjrE false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q70EL2 uniprotkb:O00442 intact:EBI-2513758|ensembl:ENSP00000333376|ensembl:ENSP00000424372|uniprotkb:Q9BRU1|uniprotkb:Q86T44|uniprotkb:B2RXG0|uniprotkb:Q5T062|uniprotkb:Q86TC0 intact:EBI-1045306|intact:EBI-2513784|uniprotkb:Q5VVL5|uniprotkb:Q5VVL6|uniprotkb:Q96E99|ensembl:ENSP00000359146 psi-mi:ubp45_human(display_long)|uniprotkb:USP45(gene name)|psi-mi:USP45(display_short)|uniprotkb:Ubiquitin-specific-processing protease 45(gene name synonym)|uniprotkb:Deubiquitinating enzyme 45(gene name synonym)|uniprotkb:Ubiquitin thioesterase 45(gene name synonym) psi-mi:rtca_human(display_long)|uniprotkb:RTCA(gene name)|psi-mi:RTCA(display_short)|uniprotkb:RNA terminal phosphate cyclase domain-containing protein 1(gene name synonym)|uniprotkb:RPC(gene name synonym)|uniprotkb:RPC1(gene name synonym)|uniprotkb:RTC1(gene name synonym)|uniprotkb:RTCD1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513752|imex:IM-12079-86 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000123552(gene)|ensembl:ENST00000327681(transcript)|ensembl:ENST00000500704(transcript)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0003407"(neural retina development)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016477"(cell migration)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0070911"(global genome nucleotide-excision repair)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|reactome:R-HSA-5696395|refseq:NP_001073950.1|refseq:NP_001332950.1|refseq:NP_001332951.1|refseq:XP_005267227.1 refseq:NP_001124313.1|refseq:NP_003720.1|ensembl:ENSG00000137996(gene)|ensembl:ENST00000370128(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003963"(RNA-3'-phosphate cyclase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006396"(RNA processing)|interpro:IPR000228(RNA 3'-terminal phosphate cyclase)|interpro:IPR013791(RNA 3'-terminal phosphate cyclase, subset, insert region)|interpro:IPR013792(RNA 3'-terminal phosphate cyclase/enolpyruvate transferase, alpha/beta)|interpro:IPR017770(RNA 3'-terminal phosphate cyclase, subgroup)|interpro:IPR020719|interpro:IPR023797|interpro:IPR036553|interpro:IPR037136 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:YA4AjFFI6z2m8AvdkzVdTFDvwvI9606 rogid:ELSeAyecjkIjaXMbCgL1j2HSTrQ9606 intact-crc:E407109333184CCF|rigid:jmxo2EO7D7NlpVzSgQfc/ilgjrE false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q70EL2 uniprotkb:P62487 intact:EBI-2513758|ensembl:ENSP00000333376|ensembl:ENSP00000424372|uniprotkb:Q9BRU1|uniprotkb:Q86T44|uniprotkb:B2RXG0|uniprotkb:Q5T062|uniprotkb:Q86TC0 intact:EBI-347928|ensembl:ENSP00000301788|uniprotkb:P52433|uniprotkb:Q2M1Z4|uniprotkb:B2R5C0 psi-mi:ubp45_human(display_long)|uniprotkb:USP45(gene name)|psi-mi:USP45(display_short)|uniprotkb:Ubiquitin-specific-processing protease 45(gene name synonym)|uniprotkb:Deubiquitinating enzyme 45(gene name synonym)|uniprotkb:Ubiquitin thioesterase 45(gene name synonym) psi-mi:rpb7_human(display_long)|uniprotkb:POLR2G(gene name)|psi-mi:POLR2G(display_short)|uniprotkb:DNA-directed RNA polymerase II subunit G(gene name synonym)|uniprotkb:RPB7(gene name synonym)|uniprotkb:RNA polymerase II 19 kDa subunit(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513752|imex:IM-12079-86 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000123552(gene)|ensembl:ENST00000327681(transcript)|ensembl:ENST00000500704(transcript)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0003407"(neural retina development)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016477"(cell migration)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0070911"(global genome nucleotide-excision repair)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|reactome:R-HSA-5696395|refseq:NP_001073950.1|refseq:NP_001332950.1|refseq:NP_001332951.1|refseq:XP_005267227.1 ensembl:ENSG00000168002(gene)|ensembl:ENST00000301788(transcript)|go:"GO:0000291"(nuclear-transcribed mRNA catabolic process, exonucleolytic)|go:"GO:0000932"(P-body)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003899"(DNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005665"(RNA polymerase II, core complex)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0006915"(apoptotic process)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0060213"("positive regulation of nuclear-transcribed mRNA poly(A) tail shortening")|interpro:IPR003029(S1, RNA binding)|interpro:IPR005576(RNA polymerase Rpb7, N-terminal)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR022967|interpro:IPR036898|mint:P62487|rcsb pdb:2C35|rcsb pdb:5IYA|rcsb pdb:5IY6|rcsb pdb:5IYB|rcsb pdb:5IYC|rcsb pdb:5IYD|rcsb pdb:6DRD|rcsb pdb:6O9L|rcsb pdb:6XRE|rcsb pdb:7LBM|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167160|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|rcsb pdb:5IY7|reactome:R-HSA-167200|reactome:R-HSA-167238|rcsb pdb:5IY8|rcsb pdb:5IY9|reactome:R-HSA-167242|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-168325|reactome:R-HSA-203927|reactome:R-HSA-5578749|reactome:R-HSA-5617472|reactome:R-HSA-674695|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6796648|reactome:R-HSA-6803529|reactome:R-HSA-6807505|reactome:R-HSA-72086|reactome:R-HSA-72163|reactome:R-HSA-72165|reactome:R-HSA-72203|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-5601884|reactome:R-HSA-75953|reactome:R-HSA-75955|reactome:R-HSA-76042|reactome:R-HSA-77075|reactome:R-HSA-8851708|reactome:R-HSA-9018519|reactome:R-HSA-9670095|refseq:NP_002687.1|dip:DIP-32663N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:YA4AjFFI6z2m8AvdkzVdTFDvwvI9606 rogid:MtnIweuhSqLFov0c40uOiwv8Eas9606 intact-crc:E407109333184CCF|rigid:jmxo2EO7D7NlpVzSgQfc/ilgjrE false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q70EL2 uniprotkb:Q8N5C6 intact:EBI-2513758|ensembl:ENSP00000333376|ensembl:ENSP00000424372|uniprotkb:Q9BRU1|uniprotkb:Q86T44|uniprotkb:B2RXG0|uniprotkb:Q5T062|uniprotkb:Q86TC0 intact:EBI-2513767|ensembl:ENSP00000263736|uniprotkb:Q53T56|uniprotkb:Q96TA4|uniprotkb:Q9NW11 psi-mi:ubp45_human(display_long)|uniprotkb:USP45(gene name)|psi-mi:USP45(display_short)|uniprotkb:Ubiquitin-specific-processing protease 45(gene name synonym)|uniprotkb:Deubiquitinating enzyme 45(gene name synonym)|uniprotkb:Ubiquitin thioesterase 45(gene name synonym) psi-mi:srbd1_human(display_long)|uniprotkb:SRBD1(gene name)|psi-mi:SRBD1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513752|imex:IM-12079-86 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000123552(gene)|ensembl:ENST00000327681(transcript)|ensembl:ENST00000500704(transcript)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0003407"(neural retina development)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016477"(cell migration)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0070911"(global genome nucleotide-excision repair)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|reactome:R-HSA-5696395|refseq:NP_001073950.1|refseq:NP_001332950.1|refseq:NP_001332951.1|refseq:XP_005267227.1 ensembl:ENSG00000068784(gene)|ensembl:ENST00000263736(transcript)|go:"GO:0003729"(mRNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0006139"(nucleobase-containing compound metabolic process)|go:"GO:0006412"(translation)|interpro:IPR003029(S1, RNA binding)|interpro:IPR006641(Resolvase, RNase H-like fold)|interpro:IPR010994(RuvA domain 2-like)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR018974|interpro:IPR022967|interpro:IPR023319|interpro:IPR023323|interpro:IPR032639|refseq:NP_060549.4|interpro:IPR037027|interpro:IPR041692|interpro:IPR044146 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:YA4AjFFI6z2m8AvdkzVdTFDvwvI9606 rogid:mTBrjQa9GAzaL0m/VxFydanhbUE9606 intact-crc:E407109333184CCF|rigid:jmxo2EO7D7NlpVzSgQfc/ilgjrE false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q70EL2 uniprotkb:P60660 intact:EBI-2513758|ensembl:ENSP00000333376|ensembl:ENSP00000424372|uniprotkb:Q9BRU1|uniprotkb:Q86T44|uniprotkb:B2RXG0|uniprotkb:Q5T062|uniprotkb:Q86TC0 intact:EBI-300817|uniprotkb:P16475|uniprotkb:P24572|uniprotkb:P24573|uniprotkb:Q12790|ensembl:ENSP00000446955|ensembl:ENSP00000448101|uniprotkb:Q6IAZ0|uniprotkb:Q6IPY5|uniprotkb:Q561V9 psi-mi:ubp45_human(display_long)|uniprotkb:USP45(gene name)|psi-mi:USP45(display_short)|uniprotkb:Ubiquitin-specific-processing protease 45(gene name synonym)|uniprotkb:Deubiquitinating enzyme 45(gene name synonym)|uniprotkb:Ubiquitin thioesterase 45(gene name synonym) psi-mi:myl6_human(display_long)|uniprotkb:MYL6(gene name)|psi-mi:MYL6(display_short)|uniprotkb:Smooth muscle and nonmuscle myosin light chain alkali 6(gene name synonym)|uniprotkb:Myosin light chain alkali 3(gene name synonym)|uniprotkb:Myosin light chain 3(gene name synonym)|uniprotkb:17 kDa myosin light chain(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513752|imex:IM-12079-86 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000123552(gene)|ensembl:ENST00000327681(transcript)|ensembl:ENST00000500704(transcript)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0003407"(neural retina development)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016477"(cell migration)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0070911"(global genome nucleotide-excision repair)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|reactome:R-HSA-5696395|refseq:NP_001073950.1|refseq:NP_001332950.1|refseq:NP_001332951.1|refseq:XP_005267227.1 ensembl:ENSG00000092841(gene)|ensembl:ENST00000548293(transcript)|ensembl:ENST00000550697(transcript)|go:"GO:0000146"(microfilament motor activity)|go:"GO:0003774"(cytoskeletal motor activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005829"(cytosol)|go:"GO:0005903"(brush border)|go:"GO:0006936"(muscle contraction)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0008307"(structural constituent of muscle)|go:"GO:0016020"(membrane)|go:"GO:0016459"(myosin complex)|go:"GO:0016461"(unconventional myosin complex)|go:"GO:0030049"(muscle filament sliding)|go:"GO:0031982"(vesicle)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|mint:P60660|reactome:R-HSA-3928663|reactome:R-HSA-416572|reactome:R-HSA-445355|reactome:R-HSA-5625740|reactome:R-HSA-5625900|reactome:R-HSA-5627117|reactome:R-HSA-5627123|refseq:NP_066299.2|refseq:NP_524147.2 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:YA4AjFFI6z2m8AvdkzVdTFDvwvI9606 rogid:LhE3NUqcuHlOla13C0vjnFZfzy89606 intact-crc:E407109333184CCF|rigid:jmxo2EO7D7NlpVzSgQfc/ilgjrE false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q70EL2 uniprotkb:Q9ULV4 intact:EBI-2513758|ensembl:ENSP00000333376|ensembl:ENSP00000424372|uniprotkb:Q9BRU1|uniprotkb:Q86T44|uniprotkb:B2RXG0|uniprotkb:Q5T062|uniprotkb:Q86TC0 intact:EBI-351384|uniprotkb:Q9NSK5|uniprotkb:B3KU12|ensembl:ENSP00000261401|ensembl:ENSP00000438341|intact:EBI-4404698|uniprotkb:A7MAP0|uniprotkb:A7MAP1 psi-mi:ubp45_human(display_long)|uniprotkb:USP45(gene name)|psi-mi:USP45(display_short)|uniprotkb:Ubiquitin-specific-processing protease 45(gene name synonym)|uniprotkb:Deubiquitinating enzyme 45(gene name synonym)|uniprotkb:Ubiquitin thioesterase 45(gene name synonym) psi-mi:cor1c_human(display_long)|uniprotkb:CORO1C(gene name)|psi-mi:CORO1C(display_short)|uniprotkb:CRNN4(gene name synonym)|uniprotkb:Coronin-3(gene name synonym)|uniprotkb:hCRNN4(gene name synonym)|uniprotkb:CRN2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513752|imex:IM-12079-86 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000123552(gene)|ensembl:ENST00000327681(transcript)|ensembl:ENST00000500704(transcript)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0003407"(neural retina development)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016477"(cell migration)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0070911"(global genome nucleotide-excision repair)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|reactome:R-HSA-5696395|refseq:NP_001073950.1|refseq:NP_001332950.1|refseq:NP_001332951.1|refseq:XP_005267227.1 refseq:NP_001263400.1|refseq:NP_055140.1|ensembl:ENSG00000110880(gene)|ensembl:ENST00000261401(transcript)|ensembl:ENST00000541050(transcript)|go:"GO:0001755"(neural crest cell migration)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0006909"(phagocytosis)|go:"GO:0007015"(actin filament organization)|go:"GO:0007165"(signal transduction)|go:"GO:0010008"(endosome membrane)|go:"GO:0010632"(regulation of epithelial cell migration)|go:"GO:0010633"(negative regulation of epithelial cell migration)|go:"GO:0030017"(sarcomere)|go:"GO:0030027"(lamellipodium)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0044387"(negative regulation of protein kinase activity by regulation of protein phosphorylation)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0051015"(actin filament binding)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0010762"(regulation of fibroblast migration)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:0090148"(membrane fission)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0016197"(endosomal transport)|go:"GO:0097750"(endosome membrane tubulation)|go:"GO:0140285"(endosome fission)|go:"GO:1900024"(regulation of substrate adhesion-dependent cell spreading)|go:"GO:1900025"(negative regulation of substrate adhesion-dependent cell spreading)|go:"GO:1900027"(regulation of ruffle assembly)|go:"GO:2000394"(positive regulation of lamellipodium morphogenesis)|interpro:IPR001680(WD40 repeat)|interpro:IPR015048(Region of unknown function DUF1899)|interpro:IPR015505(Coronin)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR027333|interpro:IPR036322|mint:Q9ULV4|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016600"(flotillin complex)|refseq:NP_001098707.1|refseq:XP_016874610.1|refseq:XP_016874611.1|refseq:XP_016874612.1|dip:DIP-33138N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:YA4AjFFI6z2m8AvdkzVdTFDvwvI9606 rogid:Em/LQxjBk9n4tobk5ksyDfFSyeU9606 intact-crc:E407109333184CCF|rigid:jmxo2EO7D7NlpVzSgQfc/ilgjrE false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q70EL2 uniprotkb:O95363 intact:EBI-2513758|ensembl:ENSP00000333376|ensembl:ENSP00000424372|uniprotkb:Q9BRU1|uniprotkb:Q86T44|uniprotkb:B2RXG0|uniprotkb:Q5T062|uniprotkb:Q86TC0 intact:EBI-2513774|ensembl:ENSP00000274680|ensembl:ENSP00000316335|uniprotkb:B2R664|uniprotkb:Q6FG29|uniprotkb:Q9NPY7|uniprotkb:Q9P062|uniprotkb:Q53F66|uniprotkb:Q5TCS3 psi-mi:ubp45_human(display_long)|uniprotkb:USP45(gene name)|psi-mi:USP45(display_short)|uniprotkb:Ubiquitin-specific-processing protease 45(gene name synonym)|uniprotkb:Deubiquitinating enzyme 45(gene name synonym)|uniprotkb:Ubiquitin thioesterase 45(gene name synonym) psi-mi:syfm_human(display_long)|uniprotkb:FARS2(gene name)|psi-mi:FARS2(display_short)|uniprotkb:FARS1(gene name synonym)|uniprotkb:Phenylalanyl-tRNA synthetase(gene name synonym)|uniprotkb:HSPC320(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513752|imex:IM-12079-86 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000123552(gene)|ensembl:ENST00000327681(transcript)|ensembl:ENST00000500704(transcript)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0003407"(neural retina development)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016477"(cell migration)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0070911"(global genome nucleotide-excision repair)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|reactome:R-HSA-5696395|refseq:NP_001073950.1|refseq:NP_001332950.1|refseq:NP_001332951.1|refseq:XP_005267227.1 ensembl:ENSG00000145982(gene)|ensembl:ENST00000274680(transcript)|ensembl:ENST00000324331(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0004826"(phenylalanine-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006418"(tRNA aminoacylation for protein translation)|go:"GO:0006432"(phenylalanyl-tRNA aminoacylation)|go:"GO:0008033"(tRNA processing)|interpro:IPR002319(Phenylalanyl-tRNA synthetase, class IIc)|interpro:IPR004530(Phenylalanyl-tRNA synthetase, class IIc, mitochondrial)|interpro:IPR005121(Phenylalanyl-tRNA synthetase, beta subunit, ferrodoxin-fold anticodon-binding)|interpro:IPR006195(Aminoacyl-tRNA synthetase, class II)|interpro:IPR036690|rcsb pdb:3CMQ|rcsb pdb:3HFV|rcsb pdb:3TEG|rcsb pdb:3TUP|rcsb pdb:5MGH|rcsb pdb:5MGU|rcsb pdb:5MGV|rcsb pdb:5MGW|reactome:R-HSA-379726|refseq:NP_001305801.1|refseq:NP_006558.1|refseq:XP_016865675.1|refseq:XP_016865676.1|refseq:XP_005248869.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:YA4AjFFI6z2m8AvdkzVdTFDvwvI9606 rogid:bClmsDMPN2mEiOKnN8nuhlWpwQc9606 intact-crc:E407109333184CCF|rigid:jmxo2EO7D7NlpVzSgQfc/ilgjrE false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q70EL2 uniprotkb:P35580 intact:EBI-2513758|ensembl:ENSP00000333376|ensembl:ENSP00000424372|uniprotkb:Q9BRU1|uniprotkb:Q86T44|uniprotkb:B2RXG0|uniprotkb:Q5T062|uniprotkb:Q86TC0 intact:EBI-351758|intact:EBI-7850240|intact:MINT-8330016|uniprotkb:B2RWP9|uniprotkb:D3DTS1|uniprotkb:Q9BWG0|uniprotkb:Q12989|uniprotkb:Q16087|uniprotkb:Q149N3|ensembl:ENSP00000269243|uniprotkb:Q149N4|uniprotkb:Q6PK16|uniprotkb:F8VTL3|uniprotkb:Q4LE45 psi-mi:ubp45_human(display_long)|uniprotkb:USP45(gene name)|psi-mi:USP45(display_short)|uniprotkb:Ubiquitin-specific-processing protease 45(gene name synonym)|uniprotkb:Deubiquitinating enzyme 45(gene name synonym)|uniprotkb:Ubiquitin thioesterase 45(gene name synonym) psi-mi:myh10_human(display_long)|uniprotkb:MYH10(gene name)|psi-mi:MYH10(display_short)|uniprotkb:Myosin heavy chain 10(gene name synonym)|uniprotkb:Myosin heavy chain, non-muscle IIb(gene name synonym)|uniprotkb:Non-muscle myosin heavy chain IIb(gene name synonym)|uniprotkb:Cellular myosin heavy chain, type B(gene name synonym)|uniprotkb:Non-muscle myosin heavy chain B(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513752|imex:IM-12079-86 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000123552(gene)|ensembl:ENST00000327681(transcript)|ensembl:ENST00000500704(transcript)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0003407"(neural retina development)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016477"(cell migration)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0070911"(global genome nucleotide-excision repair)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|reactome:R-HSA-5696395|refseq:NP_001073950.1|refseq:NP_001332950.1|refseq:NP_001332951.1|refseq:XP_005267227.1 refseq:NP_001243024.1|refseq:NP_001242941.1|refseq:NP_005955.3|ensembl:ENSG00000133026(gene)|ensembl:ENST00000269243(transcript)|go:"GO:0000146"(microfilament motor activity)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001725"(stress fiber)|go:"GO:0003779"(actin binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005938"(cell cortex)|go:"GO:0007155"(cell adhesion)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016459"(myosin complex)|go:"GO:0016460"(myosin II complex)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0030027"(lamellipodium)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0030496"(midbody)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0032154"(cleavage furrow)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0042641"(actomyosin)|go:"GO:0043531"(ADP binding)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0051015"(actin filament binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097513"(myosin II filament)|go:"GO:0098885"(modification of postsynaptic actin cytoskeleton)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR001609(Myosin head, motor region)|interpro:IPR002928(Myosin tail)|interpro:IPR004009(Myosin, N-terminal, SH3-like)|interpro:IPR008989(Myosin S1 fragment, N-terminal)|interpro:IPR027417|interpro:IPR036961|mint:P35580|rcsb pdb:4PD3|reactome:R-HSA-3928663|reactome:R-HSA-416572|reactome:R-HSA-5625740|reactome:R-HSA-5625900|reactome:R-HSA-5627117|reactome:R-HSA-5627123|refseq:XP_016880169.1|refseq:XP_016880170.1|refseq:XP_016880171.1|dip:DIP-31110N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:YA4AjFFI6z2m8AvdkzVdTFDvwvI9606 rogid:iSHfJZbrWg1L+vSpu1n7RmTTNN49606 intact-crc:E407109333184CCF|rigid:jmxo2EO7D7NlpVzSgQfc/ilgjrE false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q70EL2 uniprotkb:P06493 intact:EBI-2513758|ensembl:ENSP00000333376|ensembl:ENSP00000424372|uniprotkb:Q9BRU1|uniprotkb:Q86T44|uniprotkb:B2RXG0|uniprotkb:Q5T062|uniprotkb:Q86TC0 intact:EBI-444308|ensembl:ENSP00000378699|uniprotkb:O60764|uniprotkb:C9J497|uniprotkb:A8K7C4 psi-mi:ubp45_human(display_long)|uniprotkb:USP45(gene name)|psi-mi:USP45(display_short)|uniprotkb:Ubiquitin-specific-processing protease 45(gene name synonym)|uniprotkb:Deubiquitinating enzyme 45(gene name synonym)|uniprotkb:Ubiquitin thioesterase 45(gene name synonym) psi-mi:cdk1_human(display_long)|uniprotkb:p34 protein kinase(gene name synonym)|uniprotkb:Cell division protein kinase 1(gene name synonym)|uniprotkb:CDK1(gene name)|psi-mi:CDK1(display_short)|uniprotkb:CDC2(gene name synonym)|uniprotkb:Cell division control protein 2 homolog(gene name synonym)|uniprotkb:CDC28A(gene name synonym)|uniprotkb:CDKN1(gene name synonym)|uniprotkb:P34CDC2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513752|imex:IM-12079-86 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000123552(gene)|ensembl:ENST00000327681(transcript)|ensembl:ENST00000500704(transcript)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0003407"(neural retina development)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016477"(cell migration)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0070911"(global genome nucleotide-excision repair)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|reactome:R-HSA-5696395|refseq:NP_001073950.1|refseq:NP_001332950.1|refseq:NP_001332951.1|refseq:XP_005267227.1 go:"GO:0006281"(DNA repair)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007344"(pronuclear fusion)|go:"GO:0007569"(cell aging)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0014038"(regulation of Schwann cell differentiation)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014075"(response to amine)|go:"GO:0014823"(response to activity)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030261"(chromosome condensation)|go:"GO:0030332"(cyclin binding)|go:"GO:0030496"(midbody)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0034501"(protein localization to kinetochore)|go:"GO:0035173"(histone kinase activity)|go:"GO:0006260"(DNA replication)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0046688"(response to copper ion)|go:"GO:0048511"(rhythmic process)|go:"GO:0048678"(response to axon injury)|go:"GO:0051301"(cell division)|go:"GO:0055015"(ventricular cardiac muscle cell development)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0042493"|go:"GO:0072686"(mitotic spindle)|go:"GO:0090166"(Golgi disassembly)|go:"GO:0097125"(cyclin B1-CDK1 complex)|go:"GO:0097472"(cyclin-dependent protein kinase activity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1905448"(positive regulation of mitochondrial ATP synthesis coupled electron transport)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P06493|rcsb pdb:1LC9|rcsb pdb:4Y72|rcsb pdb:4YC3|rcsb pdb:4YC6|rcsb pdb:5HQ0|rcsb pdb:5LQF|rcsb pdb:6GU2|rcsb pdb:6GU3|rcsb pdb:6GU4|rcsb pdb:6GU6|go:"GO:0042752"(regulation of circadian rhythm)|rcsb pdb:6GU7|rcsb pdb:6TWN|reactome:R-HSA-110056|reactome:R-HSA-113507|reactome:R-HSA-1362300|reactome:R-HSA-162658|reactome:R-HSA-170145|reactome:R-HSA-174048|reactome:R-HSA-174184|reactome:R-HSA-176408|reactome:R-HSA-176412|reactome:R-HSA-176417|reactome:R-HSA-2299718|reactome:R-HSA-2465910|reactome:R-HSA-2500257|reactome:R-HSA-2514853|reactome:R-HSA-2565942|reactome:R-HSA-2980767|reactome:R-HSA-2995383|reactome:R-HSA-3301854|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-4419969|reactome:R-HSA-5620912|reactome:R-HSA-5687128|reactome:R-HSA-5689896|reactome:R-HSA-6804114|reactome:R-HSA-6804757|reactome:R-HSA-68875|reactome:R-HSA-69205|reactome:R-HSA-69273|reactome:R-HSA-69478|reactome:R-HSA-75035|reactome:R-HSA-8852276|reactome:R-HSA-8854518|reactome:R-HSA-8878166|ensembl:ENSG00000170312(gene)|ensembl:ENST00000395284(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001618"(virus receptor activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005876"(spindle microtubule)|refseq:NP_001777.1|refseq:NP_203698.1|refseq:XP_005270360.1|refseq:NP_001307847.1|dip:DIP-35N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:YA4AjFFI6z2m8AvdkzVdTFDvwvI9606 rogid:8geyXVp0Rpm8sG8I76/XgWsZ4JA9606 intact-crc:E407109333184CCF|rigid:jmxo2EO7D7NlpVzSgQfc/ilgjrE false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q70EL2 uniprotkb:Q96KR1 intact:EBI-2513758|ensembl:ENSP00000333376|ensembl:ENSP00000424372|uniprotkb:Q9BRU1|uniprotkb:Q86T44|uniprotkb:B2RXG0|uniprotkb:Q5T062|uniprotkb:Q86TC0 intact:EBI-2513582|ensembl:ENSP00000265069|uniprotkb:Q9Y687|uniprotkb:Q6P5A3|uniprotkb:B2RNR5|uniprotkb:Q9H6V4|uniprotkb:Q3B7X5|uniprotkb:Q05C08|uniprotkb:Q9NTI1|uniprotkb:Q86UA0|intact:EBI-2560216 psi-mi:ubp45_human(display_long)|uniprotkb:USP45(gene name)|psi-mi:USP45(display_short)|uniprotkb:Ubiquitin-specific-processing protease 45(gene name synonym)|uniprotkb:Deubiquitinating enzyme 45(gene name synonym)|uniprotkb:Ubiquitin thioesterase 45(gene name synonym) psi-mi:zfr_human(display_long)|uniprotkb:ZFR(gene name)|psi-mi:ZFR(display_short)|uniprotkb:M-phase phosphoprotein homolog(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513752|imex:IM-12079-86 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000123552(gene)|ensembl:ENST00000327681(transcript)|ensembl:ENST00000500704(transcript)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0003407"(neural retina development)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016477"(cell migration)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0070911"(global genome nucleotide-excision repair)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|reactome:R-HSA-5696395|refseq:NP_001073950.1|refseq:NP_001332950.1|refseq:NP_001332951.1|refseq:XP_005267227.1 ensembl:ENSG00000056097(gene)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0008270"(zinc ion binding)|interpro:IPR003604(Zinc finger, U1-type)|interpro:IPR006561(DZF)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|interpro:IPR043519|mint:Q96KR1|ensembl:ENST00000265069(transcript)|refseq:NP_057191.2|ensembl:ENSP00000265069|dip:DIP-47293N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:YA4AjFFI6z2m8AvdkzVdTFDvwvI9606 rogid:UQQP+tkUcQYka9ez6rMv2F6FXFM9606 intact-crc:E407109333184CCF|rigid:jmxo2EO7D7NlpVzSgQfc/ilgjrE false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q70EL2 uniprotkb:Q15424 intact:EBI-2513758|ensembl:ENSP00000333376|ensembl:ENSP00000424372|uniprotkb:Q9BRU1|uniprotkb:Q86T44|uniprotkb:B2RXG0|uniprotkb:Q5T062|uniprotkb:Q86TC0 intact:EBI-348298|ensembl:ENSP00000292123|uniprotkb:O60406|uniprotkb:B7Z5B6|uniprotkb:F5H0H3|uniprotkb:Q59HH8|uniprotkb:A0AV56|uniprotkb:B7ZLP6 psi-mi:ubp45_human(display_long)|uniprotkb:USP45(gene name)|psi-mi:USP45(display_short)|uniprotkb:Ubiquitin-specific-processing protease 45(gene name synonym)|uniprotkb:Deubiquitinating enzyme 45(gene name synonym)|uniprotkb:Ubiquitin thioesterase 45(gene name synonym) psi-mi:safb1_human(display_long)|uniprotkb:SAFB(gene name)|psi-mi:SAFB(display_short)|uniprotkb:HAP(gene name synonym)|uniprotkb:HET(gene name synonym)|uniprotkb:SAFB1(gene name synonym)|uniprotkb:HSP27 estrogen response element-TATA box-binding protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513752|imex:IM-12079-86 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000123552(gene)|ensembl:ENST00000327681(transcript)|ensembl:ENST00000500704(transcript)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0003407"(neural retina development)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016477"(cell migration)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0070911"(global genome nucleotide-excision repair)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|reactome:R-HSA-5696395|refseq:NP_001073950.1|refseq:NP_001332950.1|refseq:NP_001332951.1|refseq:XP_005267227.1 go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006325"(chromatin organization)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0030496"(midbody)|go:"GO:0030520"(intracellular estrogen receptor signaling pathway)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0050684"(regulation of mRNA processing)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR003034(DNA-binding SAP)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|ensembl:ENSG00000160633(gene)|interpro:IPR034781|interpro:IPR035979|ensembl:ENST00000292123(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|interpro:IPR036361|mint:Q15424|reactome:R-HSA-3899300|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003723"(RNA binding)|refseq:NP_002958.2|refseq:NP_001307500.1|refseq:NP_001307501.1|refseq:NP_001188269.1|refseq:NP_001188267.1|refseq:NP_001188268.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:YA4AjFFI6z2m8AvdkzVdTFDvwvI9606 rogid:Y31we6crSBL4G6uviNAfXyX0xfM9606 intact-crc:E407109333184CCF|rigid:jmxo2EO7D7NlpVzSgQfc/ilgjrE false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q70EL2 uniprotkb:P49750 intact:EBI-2513758|ensembl:ENSP00000333376|ensembl:ENSP00000424372|uniprotkb:Q9BRU1|uniprotkb:Q86T44|uniprotkb:B2RXG0|uniprotkb:Q5T062|uniprotkb:Q86TC0 intact:EBI-712871|ensembl:ENSP00000324463|uniprotkb:P49752|uniprotkb:Q96I64|uniprotkb:Q9P1V7 psi-mi:ubp45_human(display_long)|uniprotkb:USP45(gene name)|psi-mi:USP45(display_short)|uniprotkb:Ubiquitin-specific-processing protease 45(gene name synonym)|uniprotkb:Deubiquitinating enzyme 45(gene name synonym)|uniprotkb:Ubiquitin thioesterase 45(gene name synonym) psi-mi:ylpm1_human(display_long)|uniprotkb:Nuclear protein ZAP3(gene name synonym)|uniprotkb:ZAP113(gene name synonym)|uniprotkb:YLPM1(gene name)|psi-mi:YLPM1(display_short)|uniprotkb:C14orf170(gene name synonym)|uniprotkb:ZAP3(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513752|imex:IM-12079-86 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000123552(gene)|ensembl:ENST00000327681(transcript)|ensembl:ENST00000500704(transcript)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0003407"(neural retina development)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016477"(cell migration)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0070911"(global genome nucleotide-excision repair)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|reactome:R-HSA-5696395|refseq:NP_001073950.1|refseq:NP_001332950.1|refseq:NP_001332951.1|refseq:XP_005267227.1 ensembl:ENSG00000119596(gene)|ensembl:ENST00000325680(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016607"(nuclear speck)|go:"GO:0032204"(regulation of telomere maintenance)|interpro:IPR026314|interpro:IPR027417|refseq:NP_062535.2|ensembl:ENSP00000324463|dip:DIP-53676N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:YA4AjFFI6z2m8AvdkzVdTFDvwvI9606 rogid:3w+7odPC5D2UQYimwmCgTBbvWR49606 intact-crc:E407109333184CCF|rigid:jmxo2EO7D7NlpVzSgQfc/ilgjrE false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q70EL2 uniprotkb:P06312 intact:EBI-2513758|ensembl:ENSP00000333376|ensembl:ENSP00000424372|uniprotkb:Q9BRU1|uniprotkb:Q86T44|uniprotkb:B2RXG0|uniprotkb:Q5T062|uniprotkb:Q86TC0 intact:EBI-2513754|ensembl:ENSP00000374778|uniprotkb:P83593|uniprotkb:P01625|uniprotkb:P06313|uniprotkb:P06314 psi-mi:ubp45_human(display_long)|uniprotkb:USP45(gene name)|psi-mi:USP45(display_short)|uniprotkb:Ubiquitin-specific-processing protease 45(gene name synonym)|uniprotkb:Deubiquitinating enzyme 45(gene name synonym)|uniprotkb:Ubiquitin thioesterase 45(gene name synonym) psi-mi:kv401_human(display_long)|uniprotkb:IGKV4-1(gene name)|psi-mi:IGKV4-1(display_short)|uniprotkb:Ig kappa chain V-IV region B17(gene name synonym)|uniprotkb:Ig kappa chain V-IV region JI(gene name synonym)|uniprotkb:Ig kappa chain V-IV region Len(gene name synonym)|uniprotkb:Ig kappa chain V-IV region STH(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513752|imex:IM-12079-86 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000123552(gene)|ensembl:ENST00000327681(transcript)|ensembl:ENST00000500704(transcript)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0003407"(neural retina development)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016477"(cell migration)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0070911"(global genome nucleotide-excision repair)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|reactome:R-HSA-5696395|refseq:NP_001073950.1|refseq:NP_001332950.1|refseq:NP_001332951.1|refseq:XP_005267227.1 ensembl:ENSG00000211598(gene)|ensembl:ENST00000390243(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0003823"(antigen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0019814"(immunoglobulin complex)|go:"GO:0072562"(blood microparticle)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013106(Immunoglobulin V-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|rcsb pdb:1DH6|rcsb pdb:1EEQ|rcsb pdb:1EEU|rcsb pdb:1EFQ|rcsb pdb:1EK3|rcsb pdb:1LVE|rcsb pdb:1QAC|rcsb pdb:2LVE|rcsb pdb:3LVE|rcsb pdb:4LVE|rcsb pdb:5LVE|reactome:R-HSA-166663|reactome:R-HSA-173623|reactome:R-HSA-198933|reactome:R-HSA-202733|reactome:R-HSA-2029481|reactome:R-HSA-2029485|reactome:R-HSA-2168880|reactome:R-HSA-2454202|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-2871837|reactome:R-HSA-5690714|reactome:R-HSA-9664323|reactome:R-HSA-9664422|reactome:R-HSA-977606|reactome:R-HSA-983695|reactome:R-HSA-2029482 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:YA4AjFFI6z2m8AvdkzVdTFDvwvI9606 rogid:7c2aoJLRIQGxkxfhA+EBvIwS06g9606 intact-crc:E407109333184CCF|rigid:jmxo2EO7D7NlpVzSgQfc/ilgjrE false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q70EL2 uniprotkb:Q9NZM5 intact:EBI-2513758|ensembl:ENSP00000333376|ensembl:ENSP00000424372|uniprotkb:Q9BRU1|uniprotkb:Q86T44|uniprotkb:B2RXG0|uniprotkb:Q5T062|uniprotkb:Q86TC0 intact:EBI-720156|uniprotkb:Q9BTC6|uniprotkb:Q9HAX6|uniprotkb:Q9NPP1|uniprotkb:Q9NPR4|uniprotkb:Q9UFI2|ensembl:ENSP00000246802 psi-mi:ubp45_human(display_long)|uniprotkb:USP45(gene name)|psi-mi:USP45(display_short)|uniprotkb:Ubiquitin-specific-processing protease 45(gene name synonym)|uniprotkb:Deubiquitinating enzyme 45(gene name synonym)|uniprotkb:Ubiquitin thioesterase 45(gene name synonym) psi-mi:nop53_human(display_long)|uniprotkb:NOP53(gene name)|psi-mi:NOP53(display_short)|uniprotkb:GLT(gene name synonym)|uniprotkb:GLTSCR2(gene name synonym)|uniprotkb:Glioma tumor suppressor candidate region gene 2 protein(gene name synonym)|uniprotkb:PICT1(gene name synonym)|uniprotkb:Protein interacting with carboxyl terminus 1(gene name synonym)|uniprotkb:p60(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513752|imex:IM-12079-86 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000123552(gene)|ensembl:ENST00000327681(transcript)|ensembl:ENST00000500704(transcript)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0003407"(neural retina development)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016477"(cell migration)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0070911"(global genome nucleotide-excision repair)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|reactome:R-HSA-5696395|refseq:NP_001073950.1|refseq:NP_001332950.1|refseq:NP_001332951.1|refseq:XP_005267227.1 refseq:NP_056525.2|ensembl:ENSG00000105373(gene)|ensembl:ENST00000246802(transcript)|go:"GO:0000027"(ribosomal large subunit assembly)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001650"(fibrillar center)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0002039"(p53 binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006364"(rRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0008097"(5S rRNA binding)|go:"GO:0014067"(negative regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0039535"(regulation of RIG-I signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0003723"(RNA binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1901797"(negative regulation of signal transduction by p53 class mediator)|go:"GO:1901837"(negative regulation of transcription of nucleolar large rRNA by RNA polymerase I)|go:"GO:1902570"(protein localization to nucleolus)|go:"GO:1903006"(positive regulation of protein K63-linked deubiquitination)|go:"GO:1903715"(regulation of aerobic respiration)|go:"GO:1990173"(protein localization to nucleoplasm)|interpro:IPR011687(P60-like)|mint:Q9NZM5|go:"GO:0050821"(protein stabilization) psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:YA4AjFFI6z2m8AvdkzVdTFDvwvI9606 rogid:64EYf68f9eP9SfPBJhjbxuJcn2g9606 intact-crc:E407109333184CCF|rigid:jmxo2EO7D7NlpVzSgQfc/ilgjrE false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q70EL2 uniprotkb:P21333 intact:EBI-2513758|ensembl:ENSP00000333376|ensembl:ENSP00000424372|uniprotkb:Q9BRU1|uniprotkb:Q86T44|uniprotkb:B2RXG0|uniprotkb:Q5T062|uniprotkb:Q86TC0 intact:EBI-350432|uniprotkb:Q8NF52|intact:EBI-1103234|ensembl:ENSP00000358866|uniprotkb:Q5HY53|uniprotkb:Q5HY55|uniprotkb:E9KL45 psi-mi:ubp45_human(display_long)|uniprotkb:USP45(gene name)|psi-mi:USP45(display_short)|uniprotkb:Ubiquitin-specific-processing protease 45(gene name synonym)|uniprotkb:Deubiquitinating enzyme 45(gene name synonym)|uniprotkb:Ubiquitin thioesterase 45(gene name synonym) psi-mi:flna_human(display_long)|uniprotkb:FLNA(gene name)|psi-mi:FLNA(display_short)|uniprotkb:FLN(gene name synonym)|uniprotkb:FLN1(gene name synonym)|uniprotkb:Alpha-filamin(gene name synonym)|uniprotkb:Filamin-1(gene name synonym)|uniprotkb:Endothelial actin-binding protein(gene name synonym)|uniprotkb:Actin-binding protein 280(gene name synonym)|uniprotkb:Non-muscle filamin(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513752|imex:IM-12079-86 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000123552(gene)|ensembl:ENST00000327681(transcript)|ensembl:ENST00000500704(transcript)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0003407"(neural retina development)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016477"(cell migration)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0070911"(global genome nucleotide-excision repair)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|reactome:R-HSA-5696395|refseq:NP_001073950.1|refseq:NP_001332950.1|refseq:NP_001332951.1|refseq:XP_005267227.1 go:"GO:0007195"(adenylate cyclase-inhibiting dopamine receptor signaling pathway)|go:"GO:1902396"(protein localization to bicellular tight junction)|refseq:NP_001104026.1|refseq:NP_001447.2|ensembl:ENSG00000196924(gene)|ensembl:ENST00000369850(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003723"(RNA binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048680"(positive regulation of axon regeneration)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051015"(actin filament binding)|go:"GO:0051020"(GTPase binding)|go:"GO:0051220"(cytoplasmic sequestering of protein)|go:"GO:0051764"(actin crosslink formation)|go:"GO:0060271"(cilium assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:0071526"(semaphorin-plexin signaling pathway)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090042"(tubulin deacetylation)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:0097368"(establishment of Sertoli cell barrier)|go:"GO:0097440"(apical dendrite)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1901381"(positive regulation of potassium ion transmembrane transport)|go:"GO:0046332"(SMAD binding)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016479"(negative regulation of transcription by RNA polymerase I)|go:"GO:0019900"(kinase binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0021943"(formation of radial glial scaffolds)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030018"(Z disc)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031523"(Myb complex)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031852"(mu-type opioid receptor binding)|go:"GO:0032233"(positive regulation of actin filament bundle assembly)|go:"GO:0032432"(actin filament bundle)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0034988"(Fc-gamma receptor I complex binding)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043113"(receptor clustering)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044319"(wound healing, spreading of cells)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0045296"(cadherin binding)|reactome:R-HSA-114608|reactome:R-HSA-430116|reactome:R-HSA-446353|reactome:R-HSA-5627123|reactome:R-HSA-8983711|rcsb pdb:6EW1|go:"GO:1905031"(regulation of membrane repolarization during cardiac muscle cell action potential)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2001046"(positive regulation of integrin-mediated signaling pathway)|go:"GO:2001224"(positive regulation of neuron migration)|interpro:IPR001298(Filamin/ABP280 repeat)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017868|interpro:IPR036872|interpro:IPR044801|mint:P21333|rcsb pdb:2AAV|rcsb pdb:2BP3|rcsb pdb:2BRQ|rcsb pdb:2J3S|rcsb pdb:2JF1|rcsb pdb:2K3T|rcsb pdb:2K7P|rcsb pdb:2K7Q|rcsb pdb:2MTP|rcsb pdb:2W0P|rcsb pdb:2WFN|rcsb pdb:3CNK|rcsb pdb:3HOC|rcsb pdb:3HOP|rcsb pdb:3HOR|rcsb pdb:3ISW|rcsb pdb:3RGH|rcsb pdb:4M9P|rcsb pdb:4P3W|rcsb pdb:5XR1|rcsb pdb:6D8C|go:"GO:1905000"(regulation of membrane repolarization during atrial cardiac muscle cell action potential)|dip:DIP-1136N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:YA4AjFFI6z2m8AvdkzVdTFDvwvI9606 rogid:ZxGK5OSMy8cNsyt7Ax2KXb8bn9M9606 intact-crc:E407109333184CCF|rigid:jmxo2EO7D7NlpVzSgQfc/ilgjrE false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q70EL2 uniprotkb:Q9UKM9 intact:EBI-2513758|ensembl:ENSP00000333376|ensembl:ENSP00000424372|uniprotkb:Q9BRU1|uniprotkb:Q86T44|uniprotkb:B2RXG0|uniprotkb:Q5T062|uniprotkb:Q86TC0 intact:EBI-714796|uniprotkb:Q14621|uniprotkb:Q2M365|uniprotkb:Q5QPL8|uniprotkb:Q9BQX6|uniprotkb:Q9UJE3|ensembl:ENSP00000246194 psi-mi:ubp45_human(display_long)|uniprotkb:USP45(gene name)|psi-mi:USP45(display_short)|uniprotkb:Ubiquitin-specific-processing protease 45(gene name synonym)|uniprotkb:Deubiquitinating enzyme 45(gene name synonym)|uniprotkb:Ubiquitin thioesterase 45(gene name synonym) psi-mi:raly_human(display_long)|uniprotkb:hnRNP associated with lethal yellow protein homolog(gene name synonym)|uniprotkb:Autoantigen p542(gene name synonym)|uniprotkb:Heterogeneous nuclear ribonucleoprotein C-like 2(gene name synonym)|uniprotkb:RALY(gene name)|psi-mi:RALY(display_short)|uniprotkb:P542(gene name synonym)|uniprotkb:HNRPCL2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513752|imex:IM-12079-86 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000123552(gene)|ensembl:ENST00000327681(transcript)|ensembl:ENST00000500704(transcript)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0003407"(neural retina development)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016477"(cell migration)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0070911"(global genome nucleotide-excision repair)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|reactome:R-HSA-5696395|refseq:NP_001073950.1|refseq:NP_001332950.1|refseq:NP_001332951.1|refseq:XP_005267227.1 refseq:XP_011526996.1|refseq:XP_011526997.1|ensembl:ENSG00000125970(gene)|ensembl:ENST00000246194(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:1903506"(regulation of nucleic acid-templated transcription)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR017347(Heterogeneous nuclear ribonucleoprotein C, Raly)|interpro:IPR034502|interpro:IPR035979|mint:Q9UKM9|rcsb pdb:1WF1|refseq:NP_031393.2|refseq:NP_057951.1|refseq:XP_005260391.1|refseq:XP_005260393.1|refseq:XP_016883220.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:YA4AjFFI6z2m8AvdkzVdTFDvwvI9606 rogid:3hd0n2UW0FSRNvSJa2mqflVeorc9606 intact-crc:E407109333184CCF|rigid:jmxo2EO7D7NlpVzSgQfc/ilgjrE false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q70EL2 uniprotkb:Q15428 intact:EBI-2513758|ensembl:ENSP00000333376|ensembl:ENSP00000424372|uniprotkb:Q9BRU1|uniprotkb:Q86T44|uniprotkb:B2RXG0|uniprotkb:Q5T062|uniprotkb:Q86TC0 intact:EBI-2462271|uniprotkb:O75245|uniprotkb:B2RBU1|uniprotkb:D6W605|intact:EBI-28985293|ensembl:ENSP00000221494 psi-mi:ubp45_human(display_long)|uniprotkb:USP45(gene name)|psi-mi:USP45(display_short)|uniprotkb:Ubiquitin-specific-processing protease 45(gene name synonym)|uniprotkb:Deubiquitinating enzyme 45(gene name synonym)|uniprotkb:Ubiquitin thioesterase 45(gene name synonym) psi-mi:sf3a2_human(display_long)|uniprotkb:SF3A2(gene name)|psi-mi:SF3A2(display_short)|uniprotkb:SAP62(gene name synonym)|uniprotkb:Spliceosome-associated protein 62(gene name synonym)|uniprotkb:SF3a66(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513752|imex:IM-12079-86 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000123552(gene)|ensembl:ENST00000327681(transcript)|ensembl:ENST00000500704(transcript)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0003407"(neural retina development)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016477"(cell migration)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0070911"(global genome nucleotide-excision repair)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|reactome:R-HSA-5696395|refseq:NP_001073950.1|refseq:NP_001332950.1|refseq:NP_001332951.1|refseq:XP_005267227.1 refseq:NP_009096.2|ensembl:ENSP00000221494|dip:DIP-42521N|ensembl:ENSG00000104897(gene)|ensembl:ENST00000221494(transcript)|go:"GO:0000245"(spliceosomal complex assembly)|go:"GO:0000389"(mRNA 3'-splice site recognition)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005686"(U2 snRNP)|go:"GO:0006397"(mRNA processing)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016607"(nuclear speck)|go:"GO:0071004"(U2-type prespliceosome)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:1903241"(U2-type prespliceosome assembly)|interpro:IPR000690(Zinc finger, C2H2-type matrin)|interpro:IPR003604(Zinc finger, U1-type)|interpro:IPR031781|interpro:IPR036236|mint:Q15428|rcsb pdb:5Z56|rcsb pdb:5Z57|rcsb pdb:5Z58|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6FF4|rcsb pdb:6FF7|rcsb pdb:6QX9|rcsb pdb:6Y53|rcsb pdb:6Y5Q|rcsb pdb:7ABG|rcsb pdb:7ABH|rcsb pdb:7ABI|reactome:R-HSA-72163 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:YA4AjFFI6z2m8AvdkzVdTFDvwvI9606 rogid:ME4xzpqT37HjPl/xy683FS1Vns89606 intact-crc:E407109333184CCF|rigid:jmxo2EO7D7NlpVzSgQfc/ilgjrE false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q70EL2 uniprotkb:P38159 intact:EBI-2513758|ensembl:ENSP00000333376|ensembl:ENSP00000424372|uniprotkb:Q9BRU1|uniprotkb:Q86T44|uniprotkb:B2RXG0|uniprotkb:Q5T062|uniprotkb:Q86TC0 intact:EBI-743526|ensembl:ENSP00000359645|uniprotkb:Q5JQ67|uniprotkb:Q969R3|uniprotkb:D3DWH0|uniprotkb:E9PG86|uniprotkb:Q8N8Y7|uniprotkb:B4E3U4 psi-mi:ubp45_human(display_long)|uniprotkb:USP45(gene name)|psi-mi:USP45(display_short)|uniprotkb:Ubiquitin-specific-processing protease 45(gene name synonym)|uniprotkb:Deubiquitinating enzyme 45(gene name synonym)|uniprotkb:Ubiquitin thioesterase 45(gene name synonym) psi-mi:rbmx_human(display_long)|uniprotkb:Glycoprotein p43(gene name synonym)|uniprotkb:RBMX(gene name)|psi-mi:RBMX(display_short)|uniprotkb:HNRPG(gene name synonym)|uniprotkb:RBMXP1(gene name synonym)|uniprotkb:Heterogeneous nuclear ribonucleoprotein G(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513752|imex:IM-12079-86 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000123552(gene)|ensembl:ENST00000327681(transcript)|ensembl:ENST00000500704(transcript)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0003407"(neural retina development)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016477"(cell migration)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0070911"(global genome nucleotide-excision repair)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|reactome:R-HSA-5696395|refseq:NP_001073950.1|refseq:NP_001332950.1|refseq:NP_001332951.1|refseq:XP_005267227.1 ensembl:ENSG00000147274(gene)|ensembl:ENST00000320676(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000791"(euchromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0016020"(membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0044530"(supraspliceosomal complex)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048025"(negative regulation of mRNA splicing, via spliceosome)|go:"GO:0048026"(positive regulation of mRNA splicing, via spliceosome)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR003954(RNA recognition, region 1)|interpro:IPR012604(RBM1CTR)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR035979|mint:P38159|rcsb pdb:2MB0|rcsb pdb:2MKS|reactome:R-HSA-72163|reactome:R-HSA-72203|reactome:R-HSA-9013418|reactome:R-HSA-9013422|reactome:R-HSA-9696264|reactome:R-HSA-9696270|reactome:R-HSA-9696273|refseq:NP_002130.2|refseq:NP_001158275.1|dip:DIP-34447N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:YA4AjFFI6z2m8AvdkzVdTFDvwvI9606 rogid:ocCkdy9PxjeVLUQf0tMVCEhFfO89606 intact-crc:E407109333184CCF|rigid:jmxo2EO7D7NlpVzSgQfc/ilgjrE false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q70EL2 uniprotkb:Q9NYL9 intact:EBI-2513758|ensembl:ENSP00000333376|ensembl:ENSP00000424372|uniprotkb:Q9BRU1|uniprotkb:Q86T44|uniprotkb:B2RXG0|uniprotkb:Q5T062|uniprotkb:Q86TC0 intact:EBI-352614|ensembl:ENSP00000308753|uniprotkb:Q9NT43|uniprotkb:Q9NZR0|uniprotkb:B2R6G7 psi-mi:ubp45_human(display_long)|uniprotkb:USP45(gene name)|psi-mi:USP45(display_short)|uniprotkb:Ubiquitin-specific-processing protease 45(gene name synonym)|uniprotkb:Deubiquitinating enzyme 45(gene name synonym)|uniprotkb:Ubiquitin thioesterase 45(gene name synonym) psi-mi:tmod3_human(display_long)|uniprotkb:TMOD3(gene name)|psi-mi:TMOD3(display_short)|uniprotkb:Ubiquitous tropomodulin(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513752|imex:IM-12079-86 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000123552(gene)|ensembl:ENST00000327681(transcript)|ensembl:ENST00000500704(transcript)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0003407"(neural retina development)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016477"(cell migration)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0070911"(global genome nucleotide-excision repair)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|reactome:R-HSA-5696395|refseq:NP_001073950.1|refseq:NP_001332950.1|refseq:NP_001332951.1|refseq:XP_005267227.1 ensembl:ENSG00000138594(gene)|ensembl:ENST00000308580(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005523"(tropomyosin binding)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005865"(striated muscle thin filament)|go:"GO:0005912"(adherens junction)|go:"GO:0006936"(muscle contraction)|go:"GO:0007015"(actin filament organization)|go:"GO:0030016"(myofibril)|go:"GO:0030239"(myofibril assembly)|refseq:NP_055362.1|go:"GO:0048821"(erythrocyte development)|go:"GO:0051694"(pointed-end actin filament capping)|go:"GO:0098641"(cadherin binding involved in cell-cell adhesion)|go:"GO:1901992"(positive regulation of mitotic cell cycle phase transition)|interpro:IPR004934(Tropomodulin)|interpro:IPR030133|interpro:IPR032675|mint:Q9NYL9|reactome:R-HSA-390522|reactome:R-HSA-9013418|reactome:R-HSA-9696264|refseq:XP_016877576.1|refseq:XP_016877577.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:YA4AjFFI6z2m8AvdkzVdTFDvwvI9606 rogid:crEfCAAepSPAE8ByBpD4Sr14P5I9606 intact-crc:E407109333184CCF|rigid:jmxo2EO7D7NlpVzSgQfc/ilgjrE false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q70EL2 uniprotkb:P48736 intact:EBI-2513758|ensembl:ENSP00000333376|ensembl:ENSP00000424372|uniprotkb:Q9BRU1|uniprotkb:Q86T44|uniprotkb:B2RXG0|uniprotkb:Q5T062|uniprotkb:Q86TC0 intact:EBI-1030384|ensembl:ENSP00000352121|ensembl:ENSP00000392258|ensembl:ENSP00000419260|uniprotkb:Q8IV23|uniprotkb:Q9BZC8|uniprotkb:A4D0Q6 psi-mi:ubp45_human(display_long)|uniprotkb:USP45(gene name)|psi-mi:USP45(display_short)|uniprotkb:Ubiquitin-specific-processing protease 45(gene name synonym)|uniprotkb:Deubiquitinating enzyme 45(gene name synonym)|uniprotkb:Ubiquitin thioesterase 45(gene name synonym) psi-mi:pk3cg_human(display_long)|uniprotkb:PIK3CG(gene name)|psi-mi:PIK3CG(display_short)|uniprotkb:p120-PI3K(gene name synonym)|uniprotkb:Phosphoinositide-3-kinase catalytic gamma polypeptide(gene name synonym)|uniprotkb:Serine/threonine protein kinase PIK3CG(gene name synonym)|uniprotkb:Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit gamma(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513752|imex:IM-12079-86 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000123552(gene)|ensembl:ENST00000327681(transcript)|ensembl:ENST00000500704(transcript)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0003407"(neural retina development)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016477"(cell migration)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0070911"(global genome nucleotide-excision repair)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|reactome:R-HSA-5696395|refseq:NP_001073950.1|refseq:NP_001332950.1|refseq:NP_001332951.1|refseq:XP_005267227.1 ensembl:ENSG00000105851(gene)|ensembl:ENST00000359195(transcript)|ensembl:ENST00000440650(transcript)|ensembl:ENST00000496166(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002407"(dendritic cell chemotaxis)|go:"GO:0002675"(positive regulation of acute inflammatory response)|go:"GO:0002679"(respiratory burst involved in defense response)|go:"GO:0003376"(sphingosine-1-phosphate receptor signaling pathway)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|refseq:NP_002640.2|go:"GO:0005886"(plasma membrane)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0005944"(phosphatidylinositol 3-kinase complex, class IB)|go:"GO:0006897"(endocytosis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0010897"(negative regulation of triglyceride catabolic process)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016477"(cell migration)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0032252"(secretory granule localization)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0035004"(phosphatidylinositol 3-kinase activity)|go:"GO:0035005"(1-phosphatidylinositol-4-phosphate 3-kinase activity)|go:"GO:0035022"(positive regulation of Rac protein signal transduction)|go:"GO:0035747"(natural killer cell chemotaxis)|go:"GO:0036092"(phosphatidylinositol-3-phosphate biosynthetic process)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043303"(mast cell degranulation)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0045087"(innate immune response)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0046934"(phosphatidylinositol-4,5-bisphosphate 3-kinase activity)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0052742"(phosphatidylinositol kinase activity)|go:"GO:0052812"(phosphatidylinositol-3,4-bisphosphate 5-kinase activity)|go:"GO:0055118"(negative regulation of cardiac muscle contraction)|go:"GO:0070527"(platelet aggregation)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0072672"(neutrophil extravasation)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903169"(regulation of calcium ion transmembrane transport)|go:"GO:2000270"(negative regulation of fibroblast apoptotic process)|interpro:IPR000341(Phosphoinositide 3-kinase, ras-binding)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR001263(Phosphoinositide 3-kinase accessory region PIK)|interpro:IPR002420(Phosphoinositide 3-kinase, C2)|interpro:IPR003113(Phosphatidylinositol 3-kinase, p85-binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015433(Phosphatidylinositol Kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR029071|interpro:IPR035892|interpro:IPR036940|interpro:IPR042236|rcsb pdb:1E8Y|rcsb pdb:1E8Z|rcsb pdb:1HE8|rcsb pdb:2A4Z|rcsb pdb:2A5U|rcsb pdb:2CHW|rcsb pdb:2CHX|rcsb pdb:2CHZ|rcsb pdb:2V4L|rcsb pdb:3APC|rcsb pdb:3APD|rcsb pdb:3APF|rcsb pdb:3CSF|rcsb pdb:3CST|rcsb pdb:3DBS|rcsb pdb:3DPD|rcsb pdb:3ENE|rcsb pdb:3IBE|rcsb pdb:3L08|rcsb pdb:3L13|rcsb pdb:3L16|rcsb pdb:3L17|rcsb pdb:3L54|rcsb pdb:3LJ3|rcsb pdb:3MJW|rcsb pdb:3ML8|rcsb pdb:3ML9|rcsb pdb:3NZS|rcsb pdb:3NZU|rcsb pdb:3OAW|rcsb pdb:3P2B|rcsb pdb:3PRE|rcsb pdb:3PRZ|rcsb pdb:3PS6|rcsb pdb:3QAQ|rcsb pdb:3QAR|rcsb pdb:3QJZ|rcsb pdb:3QK0|rcsb pdb:3R7Q|rcsb pdb:3R7R|rcsb pdb:3S2A|rcsb pdb:3T8M|rcsb pdb:3TJP|rcsb pdb:3TL5|rcsb pdb:3ZVV|rcsb pdb:3ZW3|rcsb pdb:4ANU|rcsb pdb:4ANV|rcsb pdb:4ANW|rcsb pdb:4ANX|rcsb pdb:4AOF|rcsb pdb:4DK5|rcsb pdb:4EZJ|rcsb pdb:4EZK|rcsb pdb:4EZL|rcsb pdb:4F1S|rcsb pdb:4FA6|rcsb pdb:4FAD|rcsb pdb:4FHJ|rcsb pdb:4FHK|rcsb pdb:4FJY|rcsb pdb:4FJZ|rcsb pdb:4FLH|rcsb pdb:4FUL|rcsb pdb:4G11|rcsb pdb:4GB9|rcsb pdb:4HLE|rcsb pdb:4HVB|rcsb pdb:4J6I|rcsb pdb:4KZ0|rcsb pdb:4KZC|rcsb pdb:4PS3|rcsb pdb:4PS7|rcsb pdb:4PS8|rcsb pdb:4URK|rcsb pdb:4WWN|rcsb pdb:4WWO|rcsb pdb:4WWP|rcsb pdb:4XX5|rcsb pdb:4XZ4|rcsb pdb:5EDS|rcsb pdb:5G2N|rcsb pdb:3SD5|rcsb pdb:5G55|rcsb pdb:5JHA|rcsb pdb:5JHB|rcsb pdb:5KAE|rcsb pdb:5OQ4|rcsb pdb:5T23|rcsb pdb:6AUD|rcsb pdb:6FH5|rcsb pdb:6GQ7|rcsb pdb:6T3B|rcsb pdb:6T3C|rcsb pdb:6XRL|rcsb pdb:6XRM|rcsb pdb:7JWE|rcsb pdb:7JWZ|rcsb pdb:7JX0|rcsb pdb:7KKE|reactome:R-HSA-114604|reactome:R-HSA-1660499|rcsb pdb:6C1S|reactome:R-HSA-392451|reactome:R-HSA-9027276|refseq:NP_001269355.1|refseq:NP_001269356.1|refseq:XP_005250500.1|dip:DIP-37781N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:YA4AjFFI6z2m8AvdkzVdTFDvwvI9606 rogid:by9ZmIbjn8roJ0j7/BbCwBMvCDg9606 intact-crc:E407109333184CCF|rigid:jmxo2EO7D7NlpVzSgQfc/ilgjrE false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q70EK8 uniprotkb:Q92878 intact:EBI-742050|uniprotkb:Q68DA5|uniprotkb:Q8WVQ5|uniprotkb:Q9P2J7|intact:EBI-28968860|ensembl:ENSP00000274030|ensembl:ENSP00000409906 intact:EBI-495494|uniprotkb:O43254|uniprotkb:Q6GMT7|uniprotkb:Q6P5X3|uniprotkb:Q9UP86|uniprotkb:B9EGF5|ensembl:ENSP00000368100 psi-mi:ubp53_human(display_long)|uniprotkb:Inactive ubiquitin-specific peptidase 53(gene name synonym)|uniprotkb:USP53(gene name)|psi-mi:USP53(display_short)|uniprotkb:KIAA1350(gene name synonym) psi-mi:rad50_human(display_long)|uniprotkb:RAD50(gene name)|psi-mi:RAD50(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513853|imex:IM-12079-36 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0010996"(response to auditory stimulus)|refseq:NP_061923.2|ensembl:ENSP00000274030|ensembl:ENSP00000409906|ensembl:ENSG00000145390(gene)|ensembl:ENST00000450251(transcript)|go:"GO:0001508"(action potential)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007605"(sensory perception of sound)|ensembl:ENST00000274030(transcript)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0051402"(neuron apoptotic process)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR028889|interpro:IPR038765|interpro:IPR040143|refseq:XP_011530339.1|refseq:XP_005263130.1|refseq:XP_016863801.1|refseq:XP_016863802.1|refseq:XP_016863803.1|refseq:XP_016863804.1 refseq:NP_005723.2|dip:DIP-33606N|ensembl:ENSG00000113522(gene)|ensembl:ENST00000378823(transcript)|go:"GO:0000019"(regulation of mitotic recombination)|go:"GO:0000722"(telomere maintenance via recombination)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0003677"(DNA binding)|go:"GO:0003691"(double-stranded telomeric DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0016020"(membrane)|go:"GO:0016787"(hydrolase activity)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030870"(Mre11 complex)|go:"GO:0031860"(telomeric 3' overhang formation)|go:"GO:0031954"(positive regulation of protein autophosphorylation)|go:"GO:0032206"(positive regulation of telomere maintenance)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042802"(identical protein binding)|go:"GO:0043047"(single-stranded telomeric DNA binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051880"(G-quadruplex DNA binding)|go:"GO:0070192"(chromosome organization involved in meiotic cell cycle)|go:"GO:0090305"(nucleic acid phosphodiester bond hydrolysis)|go:"GO:1904354"(negative regulation of telomere capping)|interpro:IPR013134(Zinc hook, Rad50)|interpro:IPR027417|interpro:IPR038729|mint:Q92878|rcsb pdb:5GOX|reactome:R-HSA-2559586|reactome:R-HSA-5685938|reactome:R-HSA-5685939|reactome:R-HSA-5685942|reactome:R-HSA-5693548|reactome:R-HSA-5693554|reactome:R-HSA-5693565|reactome:R-HSA-5693568|reactome:R-HSA-5693571|reactome:R-HSA-5693579|reactome:R-HSA-5693607|reactome:R-HSA-5693616|reactome:R-HSA-6804756|reactome:R-HSA-69473|reactome:R-HSA-912446|interpro:IPR004584(Recombination/repair protein Rad50) psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:h3IUmdG6ippu/JhmPQiMHLhni7I9606 rogid:yZsT5GcpA9HeFMoK4Jb1HYhrdKQ9606 intact-crc:479AB9CB6DA47CF6|rigid:z0zU5l0xluFSc5n4RVwvynaBCLk false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q70EK8 uniprotkb:Q9NRH1 intact:EBI-742050|uniprotkb:Q68DA5|uniprotkb:Q8WVQ5|uniprotkb:Q9P2J7|intact:EBI-28968860|ensembl:ENSP00000274030|ensembl:ENSP00000409906 intact:EBI-712905|ensembl:ENSP00000223273|uniprotkb:B4DE83|uniprotkb:Q6IAF7|uniprotkb:Q8WVZ5|uniprotkb:A4D1W4 psi-mi:ubp53_human(display_long)|uniprotkb:Inactive ubiquitin-specific peptidase 53(gene name synonym)|uniprotkb:USP53(gene name)|psi-mi:USP53(display_short)|uniprotkb:KIAA1350(gene name synonym) psi-mi:yae1_human(display_long)|uniprotkb:YAE1(gene name)|psi-mi:YAE1(display_short)|uniprotkb:C7orf36(gene name synonym)|uniprotkb:YAE1D1(gene name synonym)|uniprotkb:Yae1 domain-containing protein 1(gene name synonym)|uniprotkb:GK003(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513853|imex:IM-12079-36 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0010996"(response to auditory stimulus)|refseq:NP_061923.2|ensembl:ENSP00000274030|ensembl:ENSP00000409906|ensembl:ENSG00000145390(gene)|ensembl:ENST00000450251(transcript)|go:"GO:0001508"(action potential)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007605"(sensory perception of sound)|ensembl:ENST00000274030(transcript)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0051402"(neuron apoptotic process)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR028889|interpro:IPR038765|interpro:IPR040143|refseq:XP_011530339.1|refseq:XP_005263130.1|refseq:XP_016863801.1|refseq:XP_016863802.1|refseq:XP_016863803.1|refseq:XP_016863804.1 ensembl:ENSG00000241127(gene)|ensembl:ENST00000223273(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0106035"(protein maturation by [4Fe-4S] cluster transfer)|interpro:IPR019191|interpro:IPR038881|refseq:NP_064577.1|refseq:NP_001269375.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:h3IUmdG6ippu/JhmPQiMHLhni7I9606 rogid:SacccNxgOBtwPZGO+BOYtapKBUI9606 intact-crc:479AB9CB6DA47CF6|rigid:z0zU5l0xluFSc5n4RVwvynaBCLk false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q70EK8 uniprotkb:P60900 intact:EBI-742050|uniprotkb:Q68DA5|uniprotkb:Q8WVQ5|uniprotkb:Q9P2J7|intact:EBI-28968860|ensembl:ENSP00000274030|ensembl:ENSP00000409906 intact:EBI-357793|uniprotkb:P34062|uniprotkb:Q6IB60|uniprotkb:B2R7J9|uniprotkb:B4DQR4|uniprotkb:B4DXJ9|ensembl:ENSP00000261479 psi-mi:ubp53_human(display_long)|uniprotkb:Inactive ubiquitin-specific peptidase 53(gene name synonym)|uniprotkb:USP53(gene name)|psi-mi:USP53(display_short)|uniprotkb:KIAA1350(gene name synonym) psi-mi:psa6_human(display_long)|uniprotkb:PSMA6(gene name)|psi-mi:PSMA6(display_short)|uniprotkb:PROS27(gene name synonym)|uniprotkb:Proteasome iota chain(gene name synonym)|uniprotkb:Macropain iota chain(gene name synonym)|uniprotkb:Multicatalytic endopeptidase complex iota chain(gene name synonym)|uniprotkb:27 kDa prosomal protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513853|imex:IM-12079-36 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0010996"(response to auditory stimulus)|refseq:NP_061923.2|ensembl:ENSP00000274030|ensembl:ENSP00000409906|ensembl:ENSG00000145390(gene)|ensembl:ENST00000450251(transcript)|go:"GO:0001508"(action potential)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007605"(sensory perception of sound)|ensembl:ENST00000274030(transcript)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0051402"(neuron apoptotic process)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR028889|interpro:IPR038765|interpro:IPR040143|refseq:XP_011530339.1|refseq:XP_005263130.1|refseq:XP_016863801.1|refseq:XP_016863802.1|refseq:XP_016863803.1|refseq:XP_016863804.1 refseq:NP_002782.1|refseq:NP_001269162.1|refseq:NP_001269163.1|refseq:XP_016876957.1|refseq:NP_001269161.1|ensembl:ENSG00000100902(gene)|ensembl:ENST00000261479(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0000932"(P-body)|go:"GO:0003723"(RNA binding)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005839"(proteasome core complex)|go:"GO:0005844"(polysome)|go:"GO:0010499"(proteasomal ubiquitin-independent protein catabolic process)|go:"GO:0016363"(nuclear matrix)|go:"GO:0019773"(proteasome core complex, alpha-subunit complex)|go:"GO:0030016"(myofibril)|go:"GO:0030017"(sarcomere)|go:"GO:0035639"(purine ribonucleoside triphosphate binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000426(Proteasome alpha-subunit, conserved site)|interpro:IPR001353(20S proteasome, A and B subunits)|interpro:IPR023332|interpro:IPR029055|interpro:IPR034642|mint:P60900|rcsb pdb:4R3O|rcsb pdb:4R67|rcsb pdb:5A0Q|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4G|rcsb pdb:5LE5|rcsb pdb:5LEX|rcsb pdb:5LEY|rcsb pdb:5LEZ|rcsb pdb:5LF0|rcsb pdb:5LF1|rcsb pdb:5LF3|rcsb pdb:5LF4|rcsb pdb:5LF6|rcsb pdb:5LF7|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFO|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:6AVO|rcsb pdb:6E5B|rcsb pdb:6KWY|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSK|rcsb pdb:6R70|rcsb pdb:6REY|rcsb pdb:6RGQ|rcsb pdb:6WJD|rcsb pdb:6WJN|rcsb pdb:6XMJ|rcsb pdb:7AWE|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|dip:DIP-29367N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:h3IUmdG6ippu/JhmPQiMHLhni7I9606 rogid:F+Kwr6rnDS3jD53gBGHDIn7HV/89606 intact-crc:479AB9CB6DA47CF6|rigid:z0zU5l0xluFSc5n4RVwvynaBCLk false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q70EK8 uniprotkb:P30154 intact:EBI-742050|uniprotkb:Q68DA5|uniprotkb:Q8WVQ5|uniprotkb:Q9P2J7|intact:EBI-28968860|ensembl:ENSP00000274030|ensembl:ENSP00000409906 intact:EBI-357094|uniprotkb:O75620|uniprotkb:Q8NHV8|uniprotkb:B0YJ69|intact:EBI-2559603|uniprotkb:B4DWW5|uniprotkb:B4DGQ6|uniprotkb:F8W8G1|uniprotkb:A8MY67|uniprotkb:B4DK91|ensembl:ENSP00000437193 psi-mi:ubp53_human(display_long)|uniprotkb:Inactive ubiquitin-specific peptidase 53(gene name synonym)|uniprotkb:USP53(gene name)|psi-mi:USP53(display_short)|uniprotkb:KIAA1350(gene name synonym) psi-mi:2aab_human(display_long)|uniprotkb:PPP2R1B(gene name)|psi-mi:PPP2R1B(display_short)|uniprotkb:PP2A subunit A isoform PR65-beta(gene name synonym)|uniprotkb:PP2A subunit A isoform R1-beta(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513853|imex:IM-12079-36 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0010996"(response to auditory stimulus)|refseq:NP_061923.2|ensembl:ENSP00000274030|ensembl:ENSP00000409906|ensembl:ENSG00000145390(gene)|ensembl:ENST00000450251(transcript)|go:"GO:0001508"(action potential)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007605"(sensory perception of sound)|ensembl:ENST00000274030(transcript)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0051402"(neuron apoptotic process)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR028889|interpro:IPR038765|interpro:IPR040143|refseq:XP_011530339.1|refseq:XP_005263130.1|refseq:XP_016863801.1|refseq:XP_016863802.1|refseq:XP_016863803.1|refseq:XP_016863804.1 dip:DIP-36616N|refseq:NP_001171033.1|refseq:NP_001171034.1|refseq:NP_002707.3|refseq:NP_859050.1|refseq:NP_859051.1|ensembl:ENST00000527614(transcript)|go:"GO:0000159"(protein phosphatase type 2A complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0045121"(membrane raft)|go:"GO:0060561"(apoptotic process involved in morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000357(HEAT)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR021133|mint:P30154|reactome:R-HSA-113501|reactome:R-HSA-141444|reactome:R-HSA-163685|reactome:R-HSA-163767|reactome:R-HSA-180024|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-198753|reactome:R-HSA-202670|reactome:R-HSA-2465910|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-389513|reactome:R-HSA-432142|reactome:R-HSA-4641262|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5467337|reactome:R-HSA-5467340|reactome:R-HSA-5467348|reactome:R-HSA-5663220|reactome:R-HSA-5673000|reactome:R-HSA-5675221|reactome:R-HSA-6804757|reactome:R-HSA-6811558|reactome:R-HSA-68877|reactome:R-HSA-69231|reactome:R-HSA-69273|reactome:R-HSA-9634600|reactome:R-HSA-9648025|ensembl:ENSG00000137713(gene) psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:h3IUmdG6ippu/JhmPQiMHLhni7I9606 rogid:fYgJ5+zyhLkZTUHV535I4LB+4iw9606 intact-crc:479AB9CB6DA47CF6|rigid:z0zU5l0xluFSc5n4RVwvynaBCLk false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q70EK8 uniprotkb:P25311 intact:EBI-742050|uniprotkb:Q68DA5|uniprotkb:Q8WVQ5|uniprotkb:Q9P2J7|intact:EBI-28968860|ensembl:ENSP00000274030|ensembl:ENSP00000409906 intact:EBI-2513837|ensembl:ENSP00000292401|uniprotkb:Q5XKQ4|uniprotkb:O60386|uniprotkb:Q8N4N0|uniprotkb:D6W5T8 psi-mi:ubp53_human(display_long)|uniprotkb:Inactive ubiquitin-specific peptidase 53(gene name synonym)|uniprotkb:USP53(gene name)|psi-mi:USP53(display_short)|uniprotkb:KIAA1350(gene name synonym) psi-mi:za2g_human(display_long)|uniprotkb:AZGP1(gene name)|psi-mi:AZGP1(display_short)|uniprotkb:ZAG(gene name synonym)|uniprotkb:ZNGP1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513853|imex:IM-12079-36 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0010996"(response to auditory stimulus)|refseq:NP_061923.2|ensembl:ENSP00000274030|ensembl:ENSP00000409906|ensembl:ENSG00000145390(gene)|ensembl:ENST00000450251(transcript)|go:"GO:0001508"(action potential)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007605"(sensory perception of sound)|ensembl:ENST00000274030(transcript)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0051402"(neuron apoptotic process)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR028889|interpro:IPR038765|interpro:IPR040143|refseq:XP_011530339.1|refseq:XP_005263130.1|refseq:XP_016863801.1|refseq:XP_016863802.1|refseq:XP_016863803.1|refseq:XP_016863804.1 ensembl:ENSG00000160862(gene)|ensembl:ENST00000292401(transcript)|go:"GO:0001580"(detection of chemical stimulus involved in sensory perception of bitter taste)|go:"GO:0001895"(retina homeostasis)|go:"GO:0002476"(antigen processing and presentation of endogenous peptide antigen via MHC class Ib)|go:"GO:0004540"(ribonuclease activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0007155"(cell adhesion)|go:"GO:0008285"(negative regulation of cell population proliferation)|interpro:IPR036179|interpro:IPR037055|mint:P25311|rcsb pdb:1T7V|rcsb pdb:1T7W|rcsb pdb:1T7X|rcsb pdb:1T7Y|rcsb pdb:1T7Z|rcsb pdb:1T80|rcsb pdb:1ZAG|rcsb pdb:3ES6|rcsb pdb:6R2U|reactome:R-HSA-5223345|go:"GO:0008320"(protein transmembrane transporter activity)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001039(MHC class I, alpha chain, alpha1 and alpha2)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011161(MHC class I-like antigen recognition)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|refseq:NP_001176.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:h3IUmdG6ippu/JhmPQiMHLhni7I9606 rogid:3Fp6qALNiZRqsI8Kh2lTQ9IMYek9606 intact-crc:479AB9CB6DA47CF6|rigid:z0zU5l0xluFSc5n4RVwvynaBCLk false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q70EK8 uniprotkb:Q08188 intact:EBI-742050|uniprotkb:Q68DA5|uniprotkb:Q8WVQ5|uniprotkb:Q9P2J7|intact:EBI-28968860|ensembl:ENSP00000274030|ensembl:ENSP00000409906 intact:EBI-1050019|uniprotkb:A8K5N6|uniprotkb:Q32MM0|uniprotkb:O95933|uniprotkb:Q32ML9|uniprotkb:B2RCR6|uniprotkb:D3DVX1|ensembl:ENSP00000370867 psi-mi:ubp53_human(display_long)|uniprotkb:Inactive ubiquitin-specific peptidase 53(gene name synonym)|uniprotkb:USP53(gene name)|psi-mi:USP53(display_short)|uniprotkb:KIAA1350(gene name synonym) psi-mi:tgm3_human(display_long)|uniprotkb:Transglutaminase-3(gene name synonym)|uniprotkb:TGM3(gene name)|psi-mi:TGM3(display_short)|uniprotkb:Transglutaminase E(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513853|imex:IM-12079-36 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0010996"(response to auditory stimulus)|refseq:NP_061923.2|ensembl:ENSP00000274030|ensembl:ENSP00000409906|ensembl:ENSG00000145390(gene)|ensembl:ENST00000450251(transcript)|go:"GO:0001508"(action potential)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007605"(sensory perception of sound)|ensembl:ENST00000274030(transcript)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0051402"(neuron apoptotic process)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR028889|interpro:IPR038765|interpro:IPR040143|refseq:XP_011530339.1|refseq:XP_005263130.1|refseq:XP_016863801.1|refseq:XP_016863802.1|refseq:XP_016863803.1|refseq:XP_016863804.1 refseq:NP_003236.3|ensembl:ENSG00000125780(gene)|ensembl:ENST00000381458(transcript)|go:"GO:0003810"(protein-glutamine gamma-glutamyltransferase activity)|go:"GO:0003824"(catalytic activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0016746"(acyltransferase activity)|go:"GO:0018149"(peptide cross-linking)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031424"(keratinization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043163"(cell envelope organization)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001102(Transglutaminase, N-terminal)|interpro:IPR002931(Transglutaminase-like)|interpro:IPR008958(Transglutaminase, C-terminal)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR013808(Transglutaminase, conserved site)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR023608|interpro:IPR036238|interpro:IPR036985|interpro:IPR038765|mint:Q08188|rcsb pdb:1L9M|rcsb pdb:1L9N|rcsb pdb:1NUD|rcsb pdb:1NUF|rcsb pdb:1NUG psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:h3IUmdG6ippu/JhmPQiMHLhni7I9606 rogid:5UuVUvhYOaQcLJQO2myrilPgFFw9606 intact-crc:479AB9CB6DA47CF6|rigid:z0zU5l0xluFSc5n4RVwvynaBCLk false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q70EK8 uniprotkb:P51610 intact:EBI-742050|uniprotkb:Q68DA5|uniprotkb:Q8WVQ5|uniprotkb:Q9P2J7|intact:EBI-28968860|ensembl:ENSP00000274030|ensembl:ENSP00000409906 intact:EBI-396176|intact:EBI-2832627|uniprotkb:Q6P4G5|intact:EBI-12037257|intact:EBI-14324845|ensembl:ENSP00000309555|intact:EBI-12980473 psi-mi:ubp53_human(display_long)|uniprotkb:Inactive ubiquitin-specific peptidase 53(gene name synonym)|uniprotkb:USP53(gene name)|psi-mi:USP53(display_short)|uniprotkb:KIAA1350(gene name synonym) psi-mi:hcfc1_human(display_long)|uniprotkb:HCFC1(gene name)|psi-mi:HCFC1(display_short)|uniprotkb:HCF1(gene name synonym)|uniprotkb:C1 factor(gene name synonym)|uniprotkb:VP16 accessory protein(gene name synonym)|uniprotkb:VCAF(gene name synonym)|uniprotkb:CFF(gene name synonym)|uniprotkb:HFC1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513853|imex:IM-12079-36 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0010996"(response to auditory stimulus)|refseq:NP_061923.2|ensembl:ENSP00000274030|ensembl:ENSP00000409906|ensembl:ENSG00000145390(gene)|ensembl:ENST00000450251(transcript)|go:"GO:0001508"(action potential)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007605"(sensory perception of sound)|ensembl:ENST00000274030(transcript)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0051402"(neuron apoptotic process)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR028889|interpro:IPR038765|interpro:IPR040143|refseq:XP_011530339.1|refseq:XP_005263130.1|refseq:XP_016863801.1|refseq:XP_016863802.1|refseq:XP_016863803.1|refseq:XP_016863804.1 refseq:NP_005325.2|refseq:XP_006724879.1|rcsb pdb:6MA1|rcsb pdb:6MA2|rcsb pdb:6MA3|rcsb pdb:6MA4|rcsb pdb:6MA5|reactome:R-HSA-2151201|reactome:R-HSA-3214847|reactome:R-HSA-5689603|ensembl:ENSG00000172534(gene)|ensembl:ENST00000310441(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000123"(histone acetyltransferase complex)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007049"(cell cycle)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0019046"(release from viral latency)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043981"(histone H4-K5 acetylation)|go:"GO:0043982"(histone H4-K8 acetylation)|go:"GO:0043984"(histone H4-K16 acetylation)|go:"GO:0045296"(cadherin binding)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048188"(Set1C/COMPASS complex)|go:"GO:0050821"(protein stabilization)|go:"GO:0071339"(MLL1 complex)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015915(Kelch-type beta propeller)|interpro:IPR036116|interpro:IPR037854|interpro:IPR043536|mint:P51610|rcsb pdb:4GO6|rcsb pdb:4N39|rcsb pdb:4N3A|rcsb pdb:4N3B|rcsb pdb:4N3C|rcsb pdb:5LWV|dip:DIP-32955N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:h3IUmdG6ippu/JhmPQiMHLhni7I9606 rogid:RzsCRe9l6md3DI87H4ZgdR9oBMI9606 intact-crc:479AB9CB6DA47CF6|rigid:z0zU5l0xluFSc5n4RVwvynaBCLk false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q70EK8 uniprotkb:P05089 intact:EBI-742050|uniprotkb:Q68DA5|uniprotkb:Q8WVQ5|uniprotkb:Q9P2J7|intact:EBI-28968860|ensembl:ENSP00000274030|ensembl:ENSP00000409906 intact:EBI-2513844|uniprotkb:Q5JWT6|uniprotkb:Q5JWT5|uniprotkb:Q9BS50|uniprotkb:Q8TE72|uniprotkb:A6NEA0|ensembl:ENSP00000357066 psi-mi:ubp53_human(display_long)|uniprotkb:Inactive ubiquitin-specific peptidase 53(gene name synonym)|uniprotkb:USP53(gene name)|psi-mi:USP53(display_short)|uniprotkb:KIAA1350(gene name synonym) psi-mi:argi1_human(display_long)|uniprotkb:ARG1(gene name)|psi-mi:ARG1(display_short)|uniprotkb:Type I arginase(gene name synonym)|uniprotkb:Liver-type arginase(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513853|imex:IM-12079-36 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0010996"(response to auditory stimulus)|refseq:NP_061923.2|ensembl:ENSP00000274030|ensembl:ENSP00000409906|ensembl:ENSG00000145390(gene)|ensembl:ENST00000450251(transcript)|go:"GO:0001508"(action potential)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007605"(sensory perception of sound)|ensembl:ENST00000274030(transcript)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0051402"(neuron apoptotic process)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR028889|interpro:IPR038765|interpro:IPR040143|refseq:XP_011530339.1|refseq:XP_005263130.1|refseq:XP_016863801.1|refseq:XP_016863802.1|refseq:XP_016863803.1|refseq:XP_016863804.1 refseq:NP_000036.2|refseq:NP_001231367.1|ensembl:ENSG00000118520(gene)|ensembl:ENST00000368087(transcript)|go:"GO:0000050"(urea cycle)|go:"GO:0001889"(liver development)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004053"(arginase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006527"(arginine catabolic process)|go:"GO:0007568"(aging)|go:"GO:0009635"(response to herbicide)|go:"GO:0010042"(response to manganese ion)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010269"(response to selenium ion)|go:"GO:0010963"|go:"GO:0014075"(response to amine)|go:"GO:0019547"(arginine catabolic process to ornithine)|go:"GO:0030145"(manganese ion binding)|go:"GO:0030324"(lung development)|go:"GO:0032964"(collagen biosynthetic process)|go:"GO:0033189"(response to vitamin A)|go:"GO:0033197"(response to vitamin E)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0035580"(specific granule lumen)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042832"(defense response to protozoan)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043200"(response to amino acid)|go:"GO:0045087"(innate immune response)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0048678"(response to axon injury)|go:"GO:0051597"(response to methylmercury)|go:"GO:0060135"(maternal process involved in female pregnancy)|go:"GO:0060336"(negative regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070965"(positive regulation of neutrophil mediated killing of fungus)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0071377"(cellular response to glucagon stimulus)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:2000552"(negative regulation of T-helper 2 cell cytokine production)|interpro:IPR006035(Ureohydrolase)|interpro:IPR014033(Arginase, subgroup)|go:"GO:0060056"(mammary gland involution)|interpro:IPR020855|interpro:IPR023696|mint:P05089|rcsb pdb:1WVA|rcsb pdb:1WVB|rcsb pdb:2AEB|rcsb pdb:2PHA|rcsb pdb:2PHO|rcsb pdb:2PLL|rcsb pdb:2ZAV|rcsb pdb:3DJ8|rcsb pdb:3E6K|rcsb pdb:3E6V|rcsb pdb:3F80|rcsb pdb:3GMZ|rcsb pdb:3GN0|rcsb pdb:3KV2|rcsb pdb:3LP4|rcsb pdb:3LP7|rcsb pdb:3MFV|rcsb pdb:3MFW|rcsb pdb:3MJL|rcsb pdb:3SJT|rcsb pdb:3SKK|rcsb pdb:3TF3|rcsb pdb:3TH7|rcsb pdb:3THE|rcsb pdb:3THH|rcsb pdb:3THJ|rcsb pdb:4FCI|rcsb pdb:4FCK|rcsb pdb:4GSM|rcsb pdb:4GSV|rcsb pdb:4GSZ|rcsb pdb:4GWC|rcsb pdb:4GWD|rcsb pdb:4HWW|rcsb pdb:4HXQ|rcsb pdb:4IE1|rcsb pdb:6Q92|rcsb pdb:6Q9P|rcsb pdb:6QAF|rcsb pdb:6V7C|rcsb pdb:6V7D|rcsb pdb:6V7E|rcsb pdb:6V7F|reactome:R-HSA-6798695|reactome:R-HSA-70635 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:h3IUmdG6ippu/JhmPQiMHLhni7I9606 rogid:b8HHscDekWZdN1S4OxFTA6rjvn89606 intact-crc:479AB9CB6DA47CF6|rigid:z0zU5l0xluFSc5n4RVwvynaBCLk false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q70EK8 uniprotkb:A6NMY6 intact:EBI-742050|uniprotkb:Q68DA5|uniprotkb:Q8WVQ5|uniprotkb:Q9P2J7|intact:EBI-28968860|ensembl:ENSP00000274030|ensembl:ENSP00000409906 intact:EBI-2513389 psi-mi:ubp53_human(display_long)|uniprotkb:Inactive ubiquitin-specific peptidase 53(gene name synonym)|uniprotkb:USP53(gene name)|psi-mi:USP53(display_short)|uniprotkb:KIAA1350(gene name synonym) psi-mi:axa2l_human(display_long)|uniprotkb:ANXA2P2(gene name)|psi-mi:ANXA2P2(display_short)|uniprotkb:ANX2L2(gene name synonym)|uniprotkb:ANX2P2(gene name synonym)|uniprotkb:LPC2B(gene name synonym)|uniprotkb:Annexin A2 pseudogene 2(gene name synonym)|uniprotkb:Lipocortin II pseudogene(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513853|imex:IM-12079-36 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0010996"(response to auditory stimulus)|refseq:NP_061923.2|ensembl:ENSP00000274030|ensembl:ENSP00000409906|ensembl:ENSG00000145390(gene)|ensembl:ENST00000450251(transcript)|go:"GO:0001508"(action potential)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007605"(sensory perception of sound)|ensembl:ENST00000274030(transcript)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0051402"(neuron apoptotic process)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR028889|interpro:IPR038765|interpro:IPR040143|refseq:XP_011530339.1|refseq:XP_005263130.1|refseq:XP_016863801.1|refseq:XP_016863802.1|refseq:XP_016863803.1|refseq:XP_016863804.1 go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0002020"(protease binding)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005544"(calcium-dependent phospholipid binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0019834"(phospholipase A2 inhibitor activity)|go:"GO:0031982"(vesicle)|go:"GO:0042470"(melanosome)|go:"GO:0046790"(virion binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001464(Annexin)|interpro:IPR018502|interpro:IPR018252|interpro:IPR002389(Annexin, type II)|mint:A6NMY6|interpro:IPR037104 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:h3IUmdG6ippu/JhmPQiMHLhni7I9606 rogid:1dVlFkkFYmN/Yn3Kv7/sCStcX089606 intact-crc:479AB9CB6DA47CF6|rigid:z0zU5l0xluFSc5n4RVwvynaBCLk false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q70EK8 uniprotkb:Q9UBL6 intact:EBI-742050|uniprotkb:Q68DA5|uniprotkb:Q8WVQ5|uniprotkb:Q9P2J7|intact:EBI-28968860|ensembl:ENSP00000274030|ensembl:ENSP00000409906 intact:EBI-744841|ensembl:ENSP00000268720 psi-mi:ubp53_human(display_long)|uniprotkb:Inactive ubiquitin-specific peptidase 53(gene name synonym)|uniprotkb:USP53(gene name)|psi-mi:USP53(display_short)|uniprotkb:KIAA1350(gene name synonym) psi-mi:cpne7_human(display_long)|uniprotkb:Copine VII(gene name synonym)|uniprotkb:CPNE7(gene name)|psi-mi:CPNE7(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513853|imex:IM-12079-36 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0010996"(response to auditory stimulus)|refseq:NP_061923.2|ensembl:ENSP00000274030|ensembl:ENSP00000409906|ensembl:ENSG00000145390(gene)|ensembl:ENST00000450251(transcript)|go:"GO:0001508"(action potential)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007605"(sensory perception of sound)|ensembl:ENST00000274030(transcript)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0051402"(neuron apoptotic process)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR028889|interpro:IPR038765|interpro:IPR040143|refseq:XP_011530339.1|refseq:XP_005263130.1|refseq:XP_016863801.1|refseq:XP_016863802.1|refseq:XP_016863803.1|refseq:XP_016863804.1 refseq:NP_055242.1|refseq:NP_705900.1|ensembl:ENSG00000178773(gene)|ensembl:ENST00000268720(transcript)|go:"GO:0005215"(transporter activity)|go:"GO:0005544"(calcium-dependent phospholipid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071277"(cellular response to calcium ion)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR010734(Copine)|interpro:IPR035892|interpro:IPR036465|interpro:IPR037768|reactome:R-HSA-1483206 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:h3IUmdG6ippu/JhmPQiMHLhni7I9606 rogid:zbz44x4Pq11/acUxb3kN/8xrVRk9606 intact-crc:479AB9CB6DA47CF6|rigid:z0zU5l0xluFSc5n4RVwvynaBCLk false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q70EK8 uniprotkb:P04040 intact:EBI-742050|uniprotkb:Q68DA5|uniprotkb:Q8WVQ5|uniprotkb:Q9P2J7|intact:EBI-28968860|ensembl:ENSP00000274030|ensembl:ENSP00000409906 intact:EBI-2432181|uniprotkb:A8K6C0|uniprotkb:B2RCZ9|uniprotkb:Q9UC85|uniprotkb:Q2M1U4|uniprotkb:Q4VXX5|uniprotkb:Q9BWT9|uniprotkb:D3DR07|ensembl:ENSP00000241052 psi-mi:ubp53_human(display_long)|uniprotkb:Inactive ubiquitin-specific peptidase 53(gene name synonym)|uniprotkb:USP53(gene name)|psi-mi:USP53(display_short)|uniprotkb:KIAA1350(gene name synonym) psi-mi:cata_human(display_long)|uniprotkb:CAT(gene name)|psi-mi:CAT(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513853|imex:IM-12079-36 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0010996"(response to auditory stimulus)|refseq:NP_061923.2|ensembl:ENSP00000274030|ensembl:ENSP00000409906|ensembl:ENSG00000145390(gene)|ensembl:ENST00000450251(transcript)|go:"GO:0001508"(action potential)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007605"(sensory perception of sound)|ensembl:ENST00000274030(transcript)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0051402"(neuron apoptotic process)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR028889|interpro:IPR038765|interpro:IPR040143|refseq:XP_011530339.1|refseq:XP_005263130.1|refseq:XP_016863801.1|refseq:XP_016863802.1|refseq:XP_016863803.1|refseq:XP_016863804.1 refseq:NP_001743.1|ensembl:ENSG00000121691(gene)|ensembl:ENST00000241052(transcript)|go:"GO:0000268"(peroxisome targeting sequence binding)|go:"GO:0000302"(response to reactive oxygen species)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001666"(response to hypoxia)|go:"GO:0004046"(aminoacylase activity)|go:"GO:0004096"(catalase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005764"(lysosome)|go:"GO:0005777"(peroxisome)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0007568"(aging)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0009060"(aerobic respiration)|go:"GO:0009642"(response to light intensity)|go:"GO:0009650"(UV protection)|go:"GO:0010193"(response to ozone)|go:"GO:0010288"(response to lead ion)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014823"(response to activity)|go:"GO:0014854"(response to inactivity)|go:"GO:0016020"(membrane)|go:"GO:0016209"(antioxidant activity)|go:"GO:0016684"(oxidoreductase activity, acting on peroxide as acceptor)|go:"GO:0019899"(enzyme binding)|go:"GO:0020027"(hemoglobin metabolic process)|go:"GO:0020037"(heme binding)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032355"(response to estradiol)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033189"(response to vitamin A)|go:"GO:0033197"(response to vitamin E)|go:"GO:0033591"(response to L-ascorbic acid)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042493"|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042744"(hydrogen peroxide catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045471"(response to ethanol)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0046872"(metal ion binding)|go:"GO:0050661"(NADP binding)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0055093"(response to hyperoxia)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070542"(response to fatty acid)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0080184"(response to phenylpropanoid)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR002226(Catalase)|interpro:IPR010582(Catalase-related)|interpro:IPR011614(Catalase, N-terminal)|interpro:IPR018028|interpro:IPR020835|interpro:IPR024708|interpro:IPR024711|interpro:IPR040333|mint:P04040|rcsb pdb:1DGB|rcsb pdb:1DGF|rcsb pdb:1DGG|rcsb pdb:1DGH|rcsb pdb:1F4J|rcsb pdb:1QQW|reactome:R-HSA-3299685|reactome:R-HSA-6798695|reactome:R-HSA-9033241|reactome:R-HSA-9615017 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:h3IUmdG6ippu/JhmPQiMHLhni7I9606 rogid:IWdPQIuCq9vCj8I0HmshkJwAAqg9606 intact-crc:479AB9CB6DA47CF6|rigid:z0zU5l0xluFSc5n4RVwvynaBCLk false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q70EK8 uniprotkb:P31944 intact:EBI-742050|uniprotkb:Q68DA5|uniprotkb:Q8WVQ5|uniprotkb:Q9P2J7|intact:EBI-28968860|ensembl:ENSP00000274030|ensembl:ENSP00000409906 intact:EBI-2510738|ensembl:ENSP00000393417|uniprotkb:O95823|uniprotkb:Q3SYC9 psi-mi:ubp53_human(display_long)|uniprotkb:Inactive ubiquitin-specific peptidase 53(gene name synonym)|uniprotkb:USP53(gene name)|psi-mi:USP53(display_short)|uniprotkb:KIAA1350(gene name synonym) psi-mi:caspe_human(display_long)|uniprotkb:CASP14(gene name)|psi-mi:CASP14(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513853|imex:IM-12079-36 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0010996"(response to auditory stimulus)|refseq:NP_061923.2|ensembl:ENSP00000274030|ensembl:ENSP00000409906|ensembl:ENSG00000145390(gene)|ensembl:ENST00000450251(transcript)|go:"GO:0001508"(action potential)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007605"(sensory perception of sound)|ensembl:ENST00000274030(transcript)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0051402"(neuron apoptotic process)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR028889|interpro:IPR038765|interpro:IPR040143|refseq:XP_011530339.1|refseq:XP_005263130.1|refseq:XP_016863801.1|refseq:XP_016863802.1|refseq:XP_016863803.1|refseq:XP_016863804.1 interpro:IPR002398(Peptidase C14, caspase precursor p45)|interpro:IPR015917(Peptidase C14, caspase precursor p45, core)|interpro:IPR029030|interpro:IPR033139|interpro:IPR033174|mint:P31944|reactome:R-HSA-6809371|ensembl:ENSG00000105141(gene)|ensembl:ENST00000427043(transcript)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0008544"(epidermis development)|go:"GO:0031424"(keratinization)|go:"GO:0045095"(keratin filament)|go:"GO:0070268"(cornification)|go:"GO:0097200"(cysteine-type endopeptidase activity involved in execution phase of apoptosis)|interpro:IPR001309(Peptidase C14, ICE, catalytic subunit p20)|interpro:IPR002138(Peptidase C14, caspase non-catalytic subunit p10)|refseq:NP_036246.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:h3IUmdG6ippu/JhmPQiMHLhni7I9606 rogid:e8QPsuebgXeKJEuMm/KU0WAOs3k9606 intact-crc:479AB9CB6DA47CF6|rigid:z0zU5l0xluFSc5n4RVwvynaBCLk false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q70EK8 uniprotkb:P01040 intact:EBI-742050|uniprotkb:Q68DA5|uniprotkb:Q8WVQ5|uniprotkb:Q9P2J7|intact:EBI-28968860|ensembl:ENSP00000274030|ensembl:ENSP00000409906 intact:EBI-724303|ensembl:ENSP00000264474|uniprotkb:Q6IB90 psi-mi:ubp53_human(display_long)|uniprotkb:Inactive ubiquitin-specific peptidase 53(gene name synonym)|uniprotkb:USP53(gene name)|psi-mi:USP53(display_short)|uniprotkb:KIAA1350(gene name synonym) psi-mi:cyta_human(display_long)|uniprotkb:Cystatin-AS(gene name synonym)|uniprotkb:Stefin-A(gene name synonym)|uniprotkb:CSTA(gene name)|psi-mi:CSTA(display_short)|uniprotkb:STF1(gene name synonym)|uniprotkb:STFA(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513853|imex:IM-12079-36 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0010996"(response to auditory stimulus)|refseq:NP_061923.2|ensembl:ENSP00000274030|ensembl:ENSP00000409906|ensembl:ENSG00000145390(gene)|ensembl:ENST00000450251(transcript)|go:"GO:0001508"(action potential)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007605"(sensory perception of sound)|ensembl:ENST00000274030(transcript)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0051402"(neuron apoptotic process)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR028889|interpro:IPR038765|interpro:IPR040143|refseq:XP_011530339.1|refseq:XP_005263130.1|refseq:XP_016863801.1|refseq:XP_016863802.1|refseq:XP_016863803.1|refseq:XP_016863804.1 refseq:NP_005204.1|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR000010(Proteinase inhibitor I25, cystatin)|interpro:IPR001713(Proteinase inhibitor I25A, stefin A)|mint:P01040|rcsb pdb:1CYU|rcsb pdb:1CYV|rcsb pdb:1DVC|rcsb pdb:1DVD|rcsb pdb:1GD3|rcsb pdb:1GD4|rcsb pdb:1N9J|rcsb pdb:1NB3|rcsb pdb:1NB5|rcsb pdb:3K9M|rcsb pdb:3KFQ|interpro:IPR018073|rcsb pdb:3KSE|reactome:R-HSA-6809371|ensembl:ENSG00000121552(gene)|ensembl:ENST00000264474(transcript)|go:"GO:0001533"(cornified envelope)|go:"GO:0002020"(protease binding)|go:"GO:0004869"(cysteine-type endopeptidase inhibitor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0010466"(negative regulation of peptidase activity)|go:"GO:0018149"(peptide cross-linking)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0045861"(negative regulation of proteolysis) psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:h3IUmdG6ippu/JhmPQiMHLhni7I9606 rogid:SzbpyWUHlOtItIvffzuwhcqFsDI9606 intact-crc:479AB9CB6DA47CF6|rigid:z0zU5l0xluFSc5n4RVwvynaBCLk false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q70EK8 uniprotkb:Q0IIN1 intact:EBI-742050|uniprotkb:Q68DA5|uniprotkb:Q8WVQ5|uniprotkb:Q9P2J7|intact:EBI-28968860|ensembl:ENSP00000274030|ensembl:ENSP00000409906 intact:EBI-2511085 psi-mi:ubp53_human(display_long)|uniprotkb:Inactive ubiquitin-specific peptidase 53(gene name synonym)|uniprotkb:USP53(gene name)|psi-mi:USP53(display_short)|uniprotkb:KIAA1350(gene name synonym) psi-mi:q0iin1_human(display_long)|uniprotkb:KRT77(gene name)|psi-mi:KRT77(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513853|imex:IM-12079-36 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0010996"(response to auditory stimulus)|refseq:NP_061923.2|ensembl:ENSP00000274030|ensembl:ENSP00000409906|ensembl:ENSG00000145390(gene)|ensembl:ENST00000450251(transcript)|go:"GO:0001508"(action potential)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007605"(sensory perception of sound)|ensembl:ENST00000274030(transcript)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0051402"(neuron apoptotic process)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR028889|interpro:IPR038765|interpro:IPR040143|refseq:XP_011530339.1|refseq:XP_005263130.1|refseq:XP_016863801.1|refseq:XP_016863802.1|refseq:XP_016863803.1|refseq:XP_016863804.1 go:"GO:0045095"(keratin filament)|refseq:NP_778253.2|interpro:IPR018039|interpro:IPR003054(Type II keratin)|interpro:IPR032444|interpro:IPR039008 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:h3IUmdG6ippu/JhmPQiMHLhni7I9606 rogid:a5ksXnU9Wj7tsqLex3Ti3+kgJyA9606 intact-crc:479AB9CB6DA47CF6|rigid:z0zU5l0xluFSc5n4RVwvynaBCLk false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q70EK8 uniprotkb:Q13867 intact:EBI-742050|uniprotkb:Q68DA5|uniprotkb:Q8WVQ5|uniprotkb:Q9P2J7|intact:EBI-28968860|ensembl:ENSP00000274030|ensembl:ENSP00000409906 intact:EBI-718504|uniprotkb:Q53F86|uniprotkb:Q9UER9|uniprotkb:B2R796|ensembl:ENSP00000261714 psi-mi:ubp53_human(display_long)|uniprotkb:Inactive ubiquitin-specific peptidase 53(gene name synonym)|uniprotkb:USP53(gene name)|psi-mi:USP53(display_short)|uniprotkb:KIAA1350(gene name synonym) psi-mi:blmh_human(display_long)|uniprotkb:BLMH(gene name)|psi-mi:BLMH(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513853|imex:IM-12079-36 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0010996"(response to auditory stimulus)|refseq:NP_061923.2|ensembl:ENSP00000274030|ensembl:ENSP00000409906|ensembl:ENSG00000145390(gene)|ensembl:ENST00000450251(transcript)|go:"GO:0001508"(action potential)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007605"(sensory perception of sound)|ensembl:ENST00000274030(transcript)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0051402"(neuron apoptotic process)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR028889|interpro:IPR038765|interpro:IPR040143|refseq:XP_011530339.1|refseq:XP_005263130.1|refseq:XP_016863801.1|refseq:XP_016863802.1|refseq:XP_016863803.1|refseq:XP_016863804.1 refseq:NP_000377.1|ensembl:ENSG00000108578(gene)|ensembl:ENST00000261714(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004177"(aminopeptidase activity)|go:"GO:0004180"(carboxypeptidase activity)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0008234"(cysteine-type peptidase activity)|go:"GO:0009636"(response to toxic substance)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043418"(homocysteine catabolic process)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000169(Peptidase, cysteine peptidase active site)|interpro:IPR004134(Peptidase C1B, bleomycin hydrolase)|interpro:IPR038765|mint:Q13867|rcsb pdb:1CB5|rcsb pdb:2CB5|reactome:R-HSA-983168 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:h3IUmdG6ippu/JhmPQiMHLhni7I9606 rogid:THDv63DC81eQzFvmyWs1rlCBMyk9606 intact-crc:479AB9CB6DA47CF6|rigid:z0zU5l0xluFSc5n4RVwvynaBCLk false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q70EK8 uniprotkb:Q14315 intact:EBI-742050|uniprotkb:Q68DA5|uniprotkb:Q8WVQ5|uniprotkb:Q9P2J7|intact:EBI-28968860|ensembl:ENSP00000274030|ensembl:ENSP00000409906 intact:EBI-489954|uniprotkb:O95303|uniprotkb:Q07985|uniprotkb:Q9NS12|uniprotkb:Q9NYE5|uniprotkb:Q9UMR8|uniprotkb:Q9Y503|uniprotkb:B2ZZ88|ensembl:ENSP00000327145 psi-mi:ubp53_human(display_long)|uniprotkb:Inactive ubiquitin-specific peptidase 53(gene name synonym)|uniprotkb:USP53(gene name)|psi-mi:USP53(display_short)|uniprotkb:KIAA1350(gene name synonym) psi-mi:flnc_human(display_long)|uniprotkb:Filamin-2(gene name synonym)|uniprotkb:Actin-binding-like protein(gene name synonym)|uniprotkb:ABP-L(gene name synonym)|uniprotkb:ABP-280-like protein(gene name synonym)|uniprotkb:Gamma-filamin(gene name synonym)|uniprotkb:FLNC(gene name)|psi-mi:FLNC(display_short)|uniprotkb:ABPL(gene name synonym)|uniprotkb:FLN2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513853|imex:IM-12079-36 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0010996"(response to auditory stimulus)|refseq:NP_061923.2|ensembl:ENSP00000274030|ensembl:ENSP00000409906|ensembl:ENSG00000145390(gene)|ensembl:ENST00000450251(transcript)|go:"GO:0001508"(action potential)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007605"(sensory perception of sound)|ensembl:ENST00000274030(transcript)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0051402"(neuron apoptotic process)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR028889|interpro:IPR038765|interpro:IPR040143|refseq:XP_011530339.1|refseq:XP_005263130.1|refseq:XP_016863801.1|refseq:XP_016863802.1|refseq:XP_016863803.1|refseq:XP_016863804.1 refseq:NP_001120959.1|refseq:NP_001449.3|ensembl:ENSG00000128591(gene)|ensembl:ENST00000325888(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0016528"(sarcoplasm)|go:"GO:0030018"(Z disc)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030506"(ankyrin binding)|go:"GO:0042383"(sarcolemma)|go:"GO:0042802"(identical protein binding)|go:"GO:0043034"(costamere)|go:"GO:0051015"(actin filament binding)|go:"GO:0055001"(muscle cell development)|interpro:IPR001298(Filamin/ABP280 repeat)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017868|interpro:IPR036872|interpro:IPR044801|mint:Q14315|rcsb pdb:1V05|rcsb pdb:2D7M|rcsb pdb:2D7N|rcsb pdb:2D7O|rcsb pdb:2D7P|rcsb pdb:2D7Q|rcsb pdb:2K9U|rcsb pdb:2NQC|rcsb pdb:3V8O|rcsb pdb:4MGX|reactome:R-HSA-446353|dip:DIP-33398N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:h3IUmdG6ippu/JhmPQiMHLhni7I9606 rogid:sBGhjObBECicoAu/8T5lDIt1ToY9606 intact-crc:479AB9CB6DA47CF6|rigid:z0zU5l0xluFSc5n4RVwvynaBCLk false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q70EK8 uniprotkb:P61254 intact:EBI-742050|uniprotkb:Q68DA5|uniprotkb:Q8WVQ5|uniprotkb:Q9P2J7|intact:EBI-28968860|ensembl:ENSP00000274030|ensembl:ENSP00000409906 intact:EBI-352405|uniprotkb:Q02877|uniprotkb:Q6IPY2|uniprotkb:B2R4F0|uniprotkb:D3DTR8|ensembl:ENSP00000462322|ensembl:ENSP00000463470|ensembl:ENSP00000463784|ensembl:ENSP00000498177 psi-mi:ubp53_human(display_long)|uniprotkb:Inactive ubiquitin-specific peptidase 53(gene name synonym)|uniprotkb:USP53(gene name)|psi-mi:USP53(display_short)|uniprotkb:KIAA1350(gene name synonym) psi-mi:rl26_human(display_long)|uniprotkb:RPL26(gene name)|psi-mi:RPL26(display_short)|uniprotkb:Large ribosomal subunit protein uL24(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513853|imex:IM-12079-36 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0010996"(response to auditory stimulus)|refseq:NP_061923.2|ensembl:ENSP00000274030|ensembl:ENSP00000409906|ensembl:ENSG00000145390(gene)|ensembl:ENST00000450251(transcript)|go:"GO:0001508"(action potential)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007605"(sensory perception of sound)|ensembl:ENST00000274030(transcript)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0051402"(neuron apoptotic process)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR028889|interpro:IPR038765|interpro:IPR040143|refseq:XP_011530339.1|refseq:XP_005263130.1|refseq:XP_016863801.1|refseq:XP_016863802.1|refseq:XP_016863803.1|refseq:XP_016863804.1 refseq:NP_000978.1|refseq:NP_001302459.1|refseq:NP_001302460.1|ensembl:ENST00000582556(transcript)|ensembl:ENST00000583011(transcript)|ensembl:ENST00000584164(transcript)|ensembl:ENST00000648839(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006364"(rRNA processing)|go:"GO:0006412"(translation)|go:"GO:0006977"(DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)|go:"GO:0016020"(membrane)|go:"GO:0022625"(cytosolic large ribosomal subunit)|ensembl:ENSG00000161970(gene)|go:"GO:0022626"(cytosolic ribosome)|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|go:"GO:0042273"(ribosomal large subunit biogenesis)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:1902164"(positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator)|go:"GO:1902167"(positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:1904803"(regulation of translation involved in cellular response to UV)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR005756(Ribosomal protein L26, eukaryotic/archaeal)|interpro:IPR005824(KOW)|interpro:IPR005825(Ribosomal protein L24/L26, conserved site)|interpro:IPR008991(Translation protein SH3-like)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR041988|mint:P61254|rcsb pdb:4UG0|rcsb pdb:4V6X|rcsb pdb:5AJ0|go:"GO:0034644"(cellular response to UV)|rcsb pdb:5T2C|rcsb pdb:6EK0|rcsb pdb:6IP5|rcsb pdb:6IP6|rcsb pdb:6IP8|rcsb pdb:6LQM|rcsb pdb:6LSR|rcsb pdb:6LSS|rcsb pdb:6LU8|rcsb pdb:6OLE|rcsb pdb:6OLF|rcsb pdb:6OLG|rcsb pdb:6OLI|rcsb pdb:6OLZ|rcsb pdb:6OM0|rcsb pdb:6OM7|rcsb pdb:6QZP|rcsb pdb:6SXO|rcsb pdb:6W6L|rcsb pdb:6XA1|rcsb pdb:6Y0G|rcsb pdb:6Y2L|rcsb pdb:6Y57|rcsb pdb:6Y6X|rcsb pdb:6Z6L|rcsb pdb:6Z6M|rcsb pdb:6Z6N|rcsb pdb:6ZM7|rcsb pdb:6ZME|rcsb pdb:6ZMI|rcsb pdb:6ZMO|rcsb pdb:7BHP|rcsb pdb:5LKS|reactome:R-HSA-156827|dip:DIP-33198N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:h3IUmdG6ippu/JhmPQiMHLhni7I9606 rogid:VAROWOFmYvolVgc/e5E1jAmNuaY9606 intact-crc:479AB9CB6DA47CF6|rigid:z0zU5l0xluFSc5n4RVwvynaBCLk false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q70EK8 uniprotkb:Q02413 intact:EBI-742050|uniprotkb:Q68DA5|uniprotkb:Q8WVQ5|uniprotkb:Q9P2J7|intact:EBI-28968860|ensembl:ENSP00000274030|ensembl:ENSP00000409906 intact:EBI-1045757|intact:EBI-28968615|ensembl:ENSP00000257192|uniprotkb:B7Z845 psi-mi:ubp53_human(display_long)|uniprotkb:Inactive ubiquitin-specific peptidase 53(gene name synonym)|uniprotkb:USP53(gene name)|psi-mi:USP53(display_short)|uniprotkb:KIAA1350(gene name synonym) psi-mi:dsg1_human(display_long)|uniprotkb:CDHF4(gene name synonym)|uniprotkb:Desmosomal glycoprotein 1(gene name synonym)|uniprotkb:Pemphigus foliaceus antigen(gene name synonym)|uniprotkb:DSG1(gene name)|psi-mi:DSG1(display_short)|uniprotkb:Cadherin family member 4(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513853|imex:IM-12079-36 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0010996"(response to auditory stimulus)|refseq:NP_061923.2|ensembl:ENSP00000274030|ensembl:ENSP00000409906|ensembl:ENSG00000145390(gene)|ensembl:ENST00000450251(transcript)|go:"GO:0001508"(action potential)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007605"(sensory perception of sound)|ensembl:ENST00000274030(transcript)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0051402"(neuron apoptotic process)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR028889|interpro:IPR038765|interpro:IPR040143|refseq:XP_011530339.1|refseq:XP_005263130.1|refseq:XP_016863801.1|refseq:XP_016863802.1|refseq:XP_016863803.1|refseq:XP_016863804.1 ensembl:ENSP00000257192|refseq:NP_001933.2|ensembl:ENSG00000134760(gene)|ensembl:ENST00000257192(transcript)|go:"GO:0001533"(cornified envelope)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0015643"(toxic substance binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016339"(calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0030057"(desmosome)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0101003"(ficolin-1-rich granule membrane)|interpro:IPR000233(Cadherin cytoplasmic region)|interpro:IPR002126(Cadherin)|interpro:IPR009122(Desmosomal cadherin)|interpro:IPR009123(Desmoglein)|interpro:IPR015919(Cadherin-like)|interpro:IPR020894|interpro:IPR027397|mint:Q02413|reactome:R-HSA-351906|reactome:R-HSA-6798695|reactome:R-HSA-6805567|reactome:R-HSA-6809371|reactome:R-HSA-9696264|reactome:R-HSA-9696270 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:h3IUmdG6ippu/JhmPQiMHLhni7I9606 rogid:CiRFIJ9IWOol9bQpLJPxH8JArtE9606 intact-crc:479AB9CB6DA47CF6|rigid:z0zU5l0xluFSc5n4RVwvynaBCLk false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q5W0Q7 uniprotkb:P12277 intact:EBI-2513899|ensembl:ENSP00000255304|uniprotkb:Q8IYE8|uniprotkb:Q6AI45|uniprotkb:Q14109|uniprotkb:Q8IY30 intact:EBI-357706|uniprotkb:Q2LE07|uniprotkb:A8K236|uniprotkb:B2R5R4|uniprotkb:Q6FG40|uniprotkb:Q9UC66|ensembl:ENSP00000299198 psi-mi:uspl1_human(display_long)|uniprotkb:Ubiquitin-specific peptidase-like protein 1(gene name synonym)|uniprotkb:USPL1(gene name)|psi-mi:USPL1(display_short)|uniprotkb:C13orf22(gene name synonym)|uniprotkb:D13S106(gene name synonym) psi-mi:kcrb_human(display_long)|uniprotkb:CKB(gene name)|psi-mi:CKB(display_short)|uniprotkb:CKBB(gene name synonym)|uniprotkb:Creatine kinase B chain(gene name synonym)|uniprotkb:Brain creatine kinase(gene name synonym)|uniprotkb:Creatine phosphokinase B-type(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513897|imex:IM-12079-87 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000132952(gene)|ensembl:ENST00000255304(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009301"(snRNA transcription)|go:"GO:0015030"(Cajal body)|go:"GO:0016926"(protein desumoylation)|go:"GO:0030576"(Cajal body organization)|go:"GO:0032183"(SUMO binding)|go:"GO:0070140"(SUMO-specific isopeptidase activity)|interpro:IPR028889|interpro:IPR028890|interpro:IPR029388|interpro:IPR033505|interpro:IPR038765|refseq:NP_005791.3|refseq:NP_001308461.1|refseq:NP_001308462.1|refseq:NP_001308463.1|refseq:XP_005266270.1|dip:DIP-47278N refseq:NP_001814.2|go:"GO:0005829"(cytosol)|ensembl:ENSG00000166165(gene)|ensembl:ENST00000348956(transcript)|go:"GO:0004111"(creatine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0016301"(kinase activity)|go:"GO:0021549"(cerebellum development)|interpro:IPR022413|interpro:IPR022414|interpro:IPR022415|interpro:IPR036802|mint:P12277|rcsb pdb:3B6R|rcsb pdb:3DRB|rcsb pdb:3DRE|rcsb pdb:6V9H|go:"GO:0021762"(substantia nigra development)|go:"GO:0030425"(dendrite)|go:"GO:0030644"(cellular chloride ion homeostasis)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0046314"(phosphocreatine biosynthetic process)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000749("ATP:guanido phosphotransferase")|interpro:IPR014746(Glutamine synthetase/guanido kinase, catalytic region)|reactome:R-HSA-71288|reactome:R-HSA-9696264|dip:DIP-52968N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2020/03/02 rogid:k1f34cDGMScg/+VAP4YpR62Hrto9606 rogid:WLRnU8sRUfJQoaPY0edGi9xiR+g9606 intact-crc:AD067DE087BA5193|rigid:pWC1ZuzM781wqc5We0UPHExeUbQ false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q5W0Q7 uniprotkb:P52209 intact:EBI-2513899|ensembl:ENSP00000255304|uniprotkb:Q8IYE8|uniprotkb:Q6AI45|uniprotkb:Q14109|uniprotkb:Q8IY30 intact:EBI-372761|uniprotkb:Q9BWD8|intact:EBI-11020895|uniprotkb:A8K2Y9|ensembl:ENSP00000270776|uniprotkb:B4DQJ8 psi-mi:uspl1_human(display_long)|uniprotkb:Ubiquitin-specific peptidase-like protein 1(gene name synonym)|uniprotkb:USPL1(gene name)|psi-mi:USPL1(display_short)|uniprotkb:C13orf22(gene name synonym)|uniprotkb:D13S106(gene name synonym) psi-mi:6pgd_human(display_long)|uniprotkb:PGD(gene name)|psi-mi:PGD(display_short)|uniprotkb:PGDH(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513897|imex:IM-12079-87 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000132952(gene)|ensembl:ENST00000255304(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009301"(snRNA transcription)|go:"GO:0015030"(Cajal body)|go:"GO:0016926"(protein desumoylation)|go:"GO:0030576"(Cajal body organization)|go:"GO:0032183"(SUMO binding)|go:"GO:0070140"(SUMO-specific isopeptidase activity)|interpro:IPR028889|interpro:IPR028890|interpro:IPR029388|interpro:IPR033505|interpro:IPR038765|refseq:NP_005791.3|refseq:NP_001308461.1|refseq:NP_001308462.1|refseq:NP_001308463.1|refseq:XP_005266270.1|dip:DIP-47278N refseq:NP_001291380.1|refseq:NP_001291381.1|refseq:NP_002622.2|ensembl:ENSG00000142657(gene)|ensembl:ENST00000270776(transcript)|go:"GO:0004616"("phosphogluconate dehydrogenase (decarboxylating) activity")|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006098"(pentose-phosphate shunt)|go:"GO:0009051"(pentose-phosphate shunt, oxidative branch)|go:"GO:0019322"(pentose biosynthetic process)|go:"GO:0046177"(D-gluconate catabolic process)|go:"GO:0050661"(NADP binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR006113(6-phosphogluconate dehydrogenase, decarboxylating)|interpro:IPR006114(6-phosphogluconate dehydrogenase, C-terminal)|interpro:IPR006115(6-phosphogluconate dehydrogenase, NAD-binding)|interpro:IPR006183(6-phosphogluconate dehydrogenase)|interpro:IPR006184(6-phosphogluconate-binding site)|interpro:IPR008927(6-phosphogluconate dehydrogenase, C-terminal-like)|interpro:IPR013328(Dehydrogenase, multihelical)|mint:P52209|rcsb pdb:2JKV|rcsb pdb:4GWG|rcsb pdb:4GWK|rcsb pdb:5UQ9|reactome:R-HSA-71336|interpro:IPR036291 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2020/03/02 rogid:k1f34cDGMScg/+VAP4YpR62Hrto9606 rogid:SgbOgCLmdWm3QnN6fQfkHG6iunw9606 intact-crc:AD067DE087BA5193|rigid:pWC1ZuzM781wqc5We0UPHExeUbQ false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q5W0Q7 uniprotkb:P30613 intact:EBI-2513899|ensembl:ENSP00000255304|uniprotkb:Q8IYE8|uniprotkb:Q6AI45|uniprotkb:Q14109|uniprotkb:Q8IY30 intact:EBI-2117450|uniprotkb:P11973|uniprotkb:O75758|ensembl:ENSP00000339933|ensembl:ENSP00000459921 psi-mi:uspl1_human(display_long)|uniprotkb:Ubiquitin-specific peptidase-like protein 1(gene name synonym)|uniprotkb:USPL1(gene name)|psi-mi:USPL1(display_short)|uniprotkb:C13orf22(gene name synonym)|uniprotkb:D13S106(gene name synonym) psi-mi:kpyr_human(display_long)|uniprotkb:Pyruvate kinase isozymes L/R(gene name synonym)|uniprotkb:PKLR(gene name)|psi-mi:PKLR(display_short)|uniprotkb:PK1(gene name synonym)|uniprotkb:PKL(gene name synonym)|uniprotkb:R-type/L-type pyruvate kinase(gene name synonym)|uniprotkb:Red cell/liver pyruvate kinase(gene name synonym)|uniprotkb:Pyruvate kinase 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513897|imex:IM-12079-87 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000132952(gene)|ensembl:ENST00000255304(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009301"(snRNA transcription)|go:"GO:0015030"(Cajal body)|go:"GO:0016926"(protein desumoylation)|go:"GO:0030576"(Cajal body organization)|go:"GO:0032183"(SUMO binding)|go:"GO:0070140"(SUMO-specific isopeptidase activity)|interpro:IPR028889|interpro:IPR028890|interpro:IPR029388|interpro:IPR033505|interpro:IPR038765|refseq:NP_005791.3|refseq:NP_001308461.1|refseq:NP_001308462.1|refseq:NP_001308463.1|refseq:XP_005266270.1|dip:DIP-47278N refseq:NP_000289.1|refseq:NP_870986.1|ensembl:ENSG00000143627(gene)|ensembl:ENSG00000262785(gene)|ensembl:ENST00000342741(transcript)|ensembl:ENST00000572740(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0004743"(pyruvate kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006096"(glycolytic process)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0007584"(response to nutrient)|go:"GO:0009408"(response to heat)|go:"GO:0009749"(response to glucose)|go:"GO:0010226"(response to lithium ion)|go:"GO:0016301"(kinase activity)|go:"GO:0030955"(potassium ion binding)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033198"(response to ATP)|go:"GO:0042866"(pyruvate biosynthetic process)|go:"GO:0051591"(response to cAMP)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071872"(cellular response to epinephrine stimulus)|interpro:IPR001697(Pyruvate kinase)|interpro:IPR011037(Pyruvate kinase, beta-barrel-like)|interpro:IPR015793(Pyruvate kinase, barrel)|interpro:IPR015795(Pyruvate kinase, C-terminal-like)|interpro:IPR015806(Pyruvate kinase, beta-barrel)|interpro:IPR015813(Pyruvate/Phosphoenolpyruvate kinase, catalytic core)|interpro:IPR018209|interpro:IPR036918|interpro:IPR040442|rcsb pdb:2VGB|rcsb pdb:2VGF|rcsb pdb:2VGG|rcsb pdb:2VGI|rcsb pdb:4IMA|rcsb pdb:4IP7|rcsb pdb:6NN4|rcsb pdb:6NN5|rcsb pdb:6NN7|rcsb pdb:6NN8|reactome:R-HSA-163765|reactome:R-HSA-210745|reactome:R-HSA-70171 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2020/03/02 rogid:k1f34cDGMScg/+VAP4YpR62Hrto9606 rogid:7Dw4NAJv4qwG9bqTpNccySqPvhY9606 intact-crc:AD067DE087BA5193|rigid:pWC1ZuzM781wqc5We0UPHExeUbQ false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q5W0Q7 uniprotkb:P55199 intact:EBI-2513899|ensembl:ENSP00000255304|uniprotkb:Q8IYE8|uniprotkb:Q6AI45|uniprotkb:Q14109|uniprotkb:Q8IY30 intact:EBI-1245868|ensembl:ENSP00000262809 psi-mi:uspl1_human(display_long)|uniprotkb:Ubiquitin-specific peptidase-like protein 1(gene name synonym)|uniprotkb:USPL1(gene name)|psi-mi:USPL1(display_short)|uniprotkb:C13orf22(gene name synonym)|uniprotkb:D13S106(gene name synonym) psi-mi:ell_human(display_long)|uniprotkb:ELL(gene name)|psi-mi:ELL(display_short)|uniprotkb:C19orf17(gene name synonym)|uniprotkb:Eleven-nineteen lysine-rich leukemia protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513897|imex:IM-12079-87 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000132952(gene)|ensembl:ENST00000255304(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009301"(snRNA transcription)|go:"GO:0015030"(Cajal body)|go:"GO:0016926"(protein desumoylation)|go:"GO:0030576"(Cajal body organization)|go:"GO:0032183"(SUMO binding)|go:"GO:0070140"(SUMO-specific isopeptidase activity)|interpro:IPR028889|interpro:IPR028890|interpro:IPR029388|interpro:IPR033505|interpro:IPR038765|refseq:NP_005791.3|refseq:NP_001308461.1|refseq:NP_001308462.1|refseq:NP_001308463.1|refseq:XP_005266270.1|dip:DIP-47278N refseq:NP_006523.1|ensembl:ENSG00000105656(gene)|ensembl:ENST00000262809(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0008023"(transcription elongation factor complex)|go:"GO:0015030"(Cajal body)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019902"(phosphatase binding)|go:"GO:0032786"(positive regulation of DNA-templated transcription, elongation)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0035327"|go:"GO:0035363"(histone locus body)|go:"GO:0042795"(snRNA transcription by RNA polymerase II)|go:"GO:0042796"(snRNA transcription by RNA polymerase III)|go:"GO:0045945"(positive regulation of transcription by RNA polymerase III)|interpro:IPR010844(Occludin and RNA polymerase II elongation factor ELL)|interpro:IPR019464|interpro:IPR031176|interpro:IPR031184|interpro:IPR036390|interpro:IPR042065|mint:P55199|rcsb pdb:2DOA|reactome:R-HSA-112382|reactome:R-HSA-167152|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-674695|reactome:R-HSA-6781827|reactome:R-HSA-6796648|reactome:R-HSA-6807505|reactome:R-HSA-75955 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2020/03/02 rogid:k1f34cDGMScg/+VAP4YpR62Hrto9606 rogid:V5OhMxsQE0SVNxJ9fTekxKq2shA9606 intact-crc:AD067DE087BA5193|rigid:pWC1ZuzM781wqc5We0UPHExeUbQ false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q5W0Q7 uniprotkb:P33176 intact:EBI-2513899|ensembl:ENSP00000255304|uniprotkb:Q8IYE8|uniprotkb:Q6AI45|uniprotkb:Q14109|uniprotkb:Q8IY30 intact:EBI-355878|uniprotkb:A0AVB2|uniprotkb:Q5VZ85|ensembl:ENSP00000307078 psi-mi:uspl1_human(display_long)|uniprotkb:Ubiquitin-specific peptidase-like protein 1(gene name synonym)|uniprotkb:USPL1(gene name)|psi-mi:USPL1(display_short)|uniprotkb:C13orf22(gene name synonym)|uniprotkb:D13S106(gene name synonym) psi-mi:kinh_human(display_long)|uniprotkb:KIF5B(gene name)|psi-mi:KIF5B(display_short)|uniprotkb:KNS(gene name synonym)|uniprotkb:KNS1(gene name synonym)|uniprotkb:Ubiquitous kinesin heavy chain(gene name synonym)|uniprotkb:Conventional kinesin heavy chain(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513897|imex:IM-12079-87 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000132952(gene)|ensembl:ENST00000255304(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009301"(snRNA transcription)|go:"GO:0015030"(Cajal body)|go:"GO:0016926"(protein desumoylation)|go:"GO:0030576"(Cajal body organization)|go:"GO:0032183"(SUMO binding)|go:"GO:0070140"(SUMO-specific isopeptidase activity)|interpro:IPR028889|interpro:IPR028890|interpro:IPR029388|interpro:IPR033505|interpro:IPR038765|refseq:NP_005791.3|refseq:NP_001308461.1|refseq:NP_001308462.1|refseq:NP_001308463.1|refseq:XP_005266270.1|dip:DIP-47278N refseq:NP_004512.1|ensembl:ENSG00000170759(gene)|ensembl:ENST00000302418(transcript)|go:"GO:0003777"(microtubule motor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0007028"(cytoplasm organization)|go:"GO:0007411"(axon guidance)|go:"GO:0008017"(microtubule binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008574"(plus-end-directed microtubule motor activity)|go:"GO:0016020"(membrane)|go:"GO:0021766"(hippocampus development)|go:"GO:0030705"(cytoskeleton-dependent intracellular transport)|go:"GO:0031340"(positive regulation of vesicle fusion)|go:"GO:0031982"(vesicle)|go:"GO:0032230"(positive regulation of synaptic transmission, GABAergic)|go:"GO:0032418"(lysosome localization)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0034451"(centriolar satellite)|go:"GO:0035253"(ciliary rootlet)|go:"GO:0035617"(stress granule disassembly)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042267"(natural killer cell mediated cytotoxicity)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0043268"(positive regulation of potassium ion transport)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045296"(cadherin binding)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0051642"(centrosome localization)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0072383"(plus-end-directed vesicle transport along microtubule)|go:"GO:0090316"(positive regulation of intracellular protein transport)|go:"GO:0098971"(anterograde dendritic transport of neurotransmitter receptor complex)|go:"GO:0099609"(microtubule lateral binding)|go:"GO:0099641"(anterograde axonal protein transport)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905152"(positive regulation of voltage-gated sodium channel activity)|go:"GO:1990048"(anterograde neuronal dense core vesicle transport)|go:"GO:1990049"(retrograde neuronal dense core vesicle transport)|interpro:IPR001752(Kinesin, motor region)|interpro:IPR019821|interpro:IPR027417|interpro:IPR027640|interpro:IPR036961|mint:P33176|rcsb pdb:1BG2|rcsb pdb:1MKJ|rcsb pdb:2P4N|rcsb pdb:3J8X|rcsb pdb:3J8Y|rcsb pdb:4HNA|rcsb pdb:4LNU|rcsb pdb:5LT0|rcsb pdb:5LT1|rcsb pdb:5LT2|rcsb pdb:5LT3|rcsb pdb:5LT4|rcsb pdb:6OJQ|reactome:R-HSA-2132295|reactome:R-HSA-264876|reactome:R-HSA-5625970|reactome:R-HSA-6811434|reactome:R-HSA-983189|dip:DIP-29244N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2020/03/02 rogid:k1f34cDGMScg/+VAP4YpR62Hrto9606 rogid:2UUVZBn5EAd0xBA5IZDPWHX9i7U9606 intact-crc:AD067DE087BA5193|rigid:pWC1ZuzM781wqc5We0UPHExeUbQ false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q5W0Q7 uniprotkb:P12273 intact:EBI-2513899|ensembl:ENSP00000255304|uniprotkb:Q8IYE8|uniprotkb:Q6AI45|uniprotkb:Q14109|uniprotkb:Q8IY30 intact:EBI-1049746|uniprotkb:A0A963|uniprotkb:A0A9C3|uniprotkb:A0A9F3|uniprotkb:A4D2I1|ensembl:ENSP00000291009 psi-mi:uspl1_human(display_long)|uniprotkb:Ubiquitin-specific peptidase-like protein 1(gene name synonym)|uniprotkb:USPL1(gene name)|psi-mi:USPL1(display_short)|uniprotkb:C13orf22(gene name synonym)|uniprotkb:D13S106(gene name synonym) psi-mi:pip_human(display_long)|uniprotkb:Prolactin-induced protein(gene name synonym)|uniprotkb:Secretory actin-binding protein(gene name synonym)|uniprotkb:Gross cystic disease fluid protein 15(gene name synonym)|uniprotkb:gp17(gene name synonym)|uniprotkb:PIP(gene name)|psi-mi:PIP(display_short)|uniprotkb:GCDFP15(gene name synonym)|uniprotkb:GPIP4(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513897|imex:IM-12079-87 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000132952(gene)|ensembl:ENST00000255304(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009301"(snRNA transcription)|go:"GO:0015030"(Cajal body)|go:"GO:0016926"(protein desumoylation)|go:"GO:0030576"(Cajal body organization)|go:"GO:0032183"(SUMO binding)|go:"GO:0070140"(SUMO-specific isopeptidase activity)|interpro:IPR028889|interpro:IPR028890|interpro:IPR029388|interpro:IPR033505|interpro:IPR038765|refseq:NP_005791.3|refseq:NP_001308461.1|refseq:NP_001308462.1|refseq:NP_001308463.1|refseq:XP_005266270.1|dip:DIP-47278N refseq:NP_002643.1|ensembl:ENSG00000159763(gene)|ensembl:ENST00000291009(transcript)|go:"GO:0001895"(retina homeostasis)|go:"GO:0002682"(regulation of immune system process)|go:"GO:0003779"(actin binding)|go:"GO:0004190"(aspartic-type endopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0006508"(proteolysis)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0019864"(IgG binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070233"(negative regulation of T cell apoptotic process)|interpro:IPR007990(Seminal vesicle autoantigen)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|mint:P12273|rcsb pdb:3ES6|reactome:R-HSA-5223345|go:"GO:0001580"(detection of chemical stimulus involved in sensory perception of bitter taste) psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2020/03/02 rogid:k1f34cDGMScg/+VAP4YpR62Hrto9606 rogid:/OC16zeRzFp520uPPLHh+WekPPc9606 intact-crc:AD067DE087BA5193|rigid:pWC1ZuzM781wqc5We0UPHExeUbQ false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q5W0Q7 uniprotkb:P19013 intact:EBI-2513899|ensembl:ENSP00000255304|uniprotkb:Q8IYE8|uniprotkb:Q6AI45|uniprotkb:Q14109|uniprotkb:Q8IY30 intact:EBI-2371606|uniprotkb:Q6GTR8|uniprotkb:Q96LA7|uniprotkb:Q9BTL1|intact:EBI-22121113|uniprotkb:B4DRS2|uniprotkb:F8VS64|intact:EBI-22010019|intact:EBI-28973341|ensembl:ENSP00000448220 psi-mi:uspl1_human(display_long)|uniprotkb:Ubiquitin-specific peptidase-like protein 1(gene name synonym)|uniprotkb:USPL1(gene name)|psi-mi:USPL1(display_short)|uniprotkb:C13orf22(gene name synonym)|uniprotkb:D13S106(gene name synonym) psi-mi:k2c4_human(display_long)|uniprotkb:KRT4(gene name)|psi-mi:KRT4(display_short)|uniprotkb:CYK4(gene name synonym)|uniprotkb:Cytokeratin-4(gene name synonym)|uniprotkb:Keratin-4(gene name synonym)|uniprotkb:Type-II keratin Kb4(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513897|imex:IM-12079-87 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000132952(gene)|ensembl:ENST00000255304(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009301"(snRNA transcription)|go:"GO:0015030"(Cajal body)|go:"GO:0016926"(protein desumoylation)|go:"GO:0030576"(Cajal body organization)|go:"GO:0032183"(SUMO binding)|go:"GO:0070140"(SUMO-specific isopeptidase activity)|interpro:IPR028889|interpro:IPR028890|interpro:IPR029388|interpro:IPR033505|interpro:IPR038765|refseq:NP_005791.3|refseq:NP_001308461.1|refseq:NP_001308462.1|refseq:NP_001308463.1|refseq:XP_005266270.1|dip:DIP-47278N ensembl:ENSP00000448220|refseq:NP_002263.3|ensembl:ENSG00000170477(gene)|ensembl:ENST00000551956(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005882"(intermediate filament)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0009986"(cell surface)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0045095"(keratin filament)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|interpro:IPR003054(Type II keratin)|interpro:IPR018039|interpro:IPR032444|interpro:IPR039008|mint:P19013|reactome:R-HSA-6805567|reactome:R-HSA-6809371 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2020/03/02 rogid:k1f34cDGMScg/+VAP4YpR62Hrto9606 rogid:WBLRjdlqvNYbC7R2ZSNON6QLcOU9606 intact-crc:AD067DE087BA5193|rigid:pWC1ZuzM781wqc5We0UPHExeUbQ false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q5W0Q7 uniprotkb:Q9Y2F5 intact:EBI-2513899|ensembl:ENSP00000255304|uniprotkb:Q8IYE8|uniprotkb:Q6AI45|uniprotkb:Q14109|uniprotkb:Q8IY30 intact:EBI-2513919|intact:EBI-28979599|ensembl:ENSP00000296564|uniprotkb:Q9NTH9|uniprotkb:Q6ZT40|uniprotkb:Q7Z3A9|uniprotkb:Q7L587|uniprotkb:Q68DE1 psi-mi:uspl1_human(display_long)|uniprotkb:Ubiquitin-specific peptidase-like protein 1(gene name synonym)|uniprotkb:USPL1(gene name)|psi-mi:USPL1(display_short)|uniprotkb:C13orf22(gene name synonym)|uniprotkb:D13S106(gene name synonym) psi-mi:ice1_human(display_long)|uniprotkb:ICE1(gene name)|psi-mi:ICE1(display_short)|uniprotkb:Interactor of little elongator complex ELL subunit 1(gene name synonym)|uniprotkb:KIAA0947(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513897|imex:IM-12079-87 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000132952(gene)|ensembl:ENST00000255304(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009301"(snRNA transcription)|go:"GO:0015030"(Cajal body)|go:"GO:0016926"(protein desumoylation)|go:"GO:0030576"(Cajal body organization)|go:"GO:0032183"(SUMO binding)|go:"GO:0070140"(SUMO-specific isopeptidase activity)|interpro:IPR028889|interpro:IPR028890|interpro:IPR029388|interpro:IPR033505|interpro:IPR038765|refseq:NP_005791.3|refseq:NP_001308461.1|refseq:NP_001308462.1|refseq:NP_001308463.1|refseq:XP_005266270.1|dip:DIP-47278N ensembl:ENSG00000164151(gene)|ensembl:ENST00000296564(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0008023"(transcription elongation factor complex)|go:"GO:0015030"(Cajal body)|go:"GO:0016604"(nuclear body)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0035327"|go:"GO:0035363"(histone locus body)|go:"GO:0042795"(snRNA transcription by RNA polymerase II)|go:"GO:0042796"(snRNA transcription by RNA polymerase III)|go:"GO:0045945"(positive regulation of transcription by RNA polymerase III)|go:"GO:0090316"(positive regulation of intracellular protein transport)|reactome:R-HSA-6807505|refseq:NP_056140.1|ensembl:ENSP00000296564 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2020/03/02 rogid:k1f34cDGMScg/+VAP4YpR62Hrto9606 rogid:/Y2PtpCRM99fEju/i+DeMPd43to9606 intact-crc:AD067DE087BA5193|rigid:pWC1ZuzM781wqc5We0UPHExeUbQ false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q5W0Q7 uniprotkb:Q9P2R3 intact:EBI-2513899|ensembl:ENSP00000255304|uniprotkb:Q8IYE8|uniprotkb:Q6AI45|uniprotkb:Q14109|uniprotkb:Q8IY30 intact:EBI-2513908|uniprotkb:Q5RKV4|uniprotkb:Q9ULG5|uniprotkb:A8KA65|intact:EBI-2838972|intact:EBI-2948552|ensembl:ENSP00000343362|ensembl:ENSP00000497187 psi-mi:uspl1_human(display_long)|uniprotkb:Ubiquitin-specific peptidase-like protein 1(gene name synonym)|uniprotkb:USPL1(gene name)|psi-mi:USPL1(display_short)|uniprotkb:C13orf22(gene name synonym)|uniprotkb:D13S106(gene name synonym) psi-mi:anfy1_human(display_long)|uniprotkb:Ankyrin repeat and FYVE domain-containing protein 1(gene name synonym)|uniprotkb:ANKFY1(gene name)|psi-mi:ANKFY1(display_short)|uniprotkb:ANKHZN(gene name synonym)|uniprotkb:KIAA1255(gene name synonym)|uniprotkb:Ankyrin repeats hooked to a zinc finger motif(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513897|imex:IM-12079-87 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000132952(gene)|ensembl:ENST00000255304(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009301"(snRNA transcription)|go:"GO:0015030"(Cajal body)|go:"GO:0016926"(protein desumoylation)|go:"GO:0030576"(Cajal body organization)|go:"GO:0032183"(SUMO binding)|go:"GO:0070140"(SUMO-specific isopeptidase activity)|interpro:IPR028889|interpro:IPR028890|interpro:IPR029388|interpro:IPR033505|interpro:IPR038765|refseq:NP_005791.3|refseq:NP_001308461.1|refseq:NP_001308462.1|refseq:NP_001308463.1|refseq:XP_005266270.1|dip:DIP-47278N refseq:NP_057460.3|refseq:NP_001316992.1|refseq:NP_001244928.1|dip:DIP-46068N|ensembl:ENSG00000185722(gene)|ensembl:ENST00000341657(transcript)|ensembl:ENST00000648043(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006897"(endocytosis)|go:"GO:0010008"(endosome membrane)|go:"GO:0016020"(membrane)|go:"GO:0016197"(endosomal transport)|go:"GO:0031267"(small GTPase binding)|go:"GO:0034058"(endosomal vesicle fusion)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044354"(macropinosome)|go:"GO:0046872"(metal ion binding)|go:"GO:0048549"(positive regulation of pinocytosis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090160"(Golgi to lysosome transport)|go:"GO:1901981"(phosphatidylinositol phosphate binding)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR000306(Zinc finger, FYVE-type)|interpro:IPR002110(Ankyrin)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017455(Zinc finger, FYVE-related)|interpro:IPR020683|interpro:IPR036770|reactome:R-HSA-9013405 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2020/03/02 rogid:k1f34cDGMScg/+VAP4YpR62Hrto9606 rogid:237ungtRc80jqTOKBUnFX9qDUGw9606 intact-crc:AD067DE087BA5193|rigid:pWC1ZuzM781wqc5We0UPHExeUbQ false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q5W0Q7 uniprotkb:P04083 intact:EBI-2513899|ensembl:ENSP00000255304|uniprotkb:Q8IYE8|uniprotkb:Q6AI45|uniprotkb:Q14109|uniprotkb:Q8IY30 intact:EBI-354007|ensembl:ENSP00000257497|ensembl:ENSP00000366109|uniprotkb:B5BU38 psi-mi:uspl1_human(display_long)|uniprotkb:Ubiquitin-specific peptidase-like protein 1(gene name synonym)|uniprotkb:USPL1(gene name)|psi-mi:USPL1(display_short)|uniprotkb:C13orf22(gene name synonym)|uniprotkb:D13S106(gene name synonym) psi-mi:anxa1_human(display_long)|uniprotkb:ANXA1(gene name)|psi-mi:ANXA1(display_short)|uniprotkb:ANX1(gene name synonym)|uniprotkb:LPC1(gene name synonym)|uniprotkb:Annexin-1(gene name synonym)|uniprotkb:Annexin I(gene name synonym)|uniprotkb:Lipocortin I(gene name synonym)|uniprotkb:Calpactin II(gene name synonym)|uniprotkb:Chromobindin-9(gene name synonym)|uniprotkb:p35(gene name synonym)|uniprotkb:Phospholipase A2 inhibitory protein(gene name synonym)|uniprotkb:Calpactin-2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513897|imex:IM-12079-87 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000132952(gene)|ensembl:ENST00000255304(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009301"(snRNA transcription)|go:"GO:0015030"(Cajal body)|go:"GO:0016926"(protein desumoylation)|go:"GO:0030576"(Cajal body organization)|go:"GO:0032183"(SUMO binding)|go:"GO:0070140"(SUMO-specific isopeptidase activity)|interpro:IPR028889|interpro:IPR028890|interpro:IPR029388|interpro:IPR033505|interpro:IPR038765|refseq:NP_005791.3|refseq:NP_001308461.1|refseq:NP_001308462.1|refseq:NP_001308463.1|refseq:XP_005266270.1|dip:DIP-47278N refseq:NP_000691.1|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0018149"(peptide cross-linking)|go:"GO:0019834"(phospholipase A2 inhibitor activity)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0030073"(insulin secretion)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030850"(prostate gland development)|go:"GO:0031018"(endocrine pancreas development)|go:"GO:0031232"(extrinsic component of external side of plasma membrane)|go:"GO:0031313"(extrinsic component of endosome membrane)|go:"GO:0031340"(positive regulation of vesicle fusion)|go:"GO:0031394"(positive regulation of prostaglandin biosynthetic process)|go:"GO:0031514"(motile cilium)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032355"(response to estradiol)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0032652"(regulation of interleukin-1 production)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033031"(positive regulation of neutrophil apoptotic process)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0036121"(double-stranded DNA helicase activity)|go:"GO:0042063"(gliogenesis)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0042493"|go:"GO:0042629"(mast cell granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0045087"(innate immune response)|go:"GO:0045627"(positive regulation of T-helper 1 cell differentiation)|go:"GO:0045629"(negative regulation of T-helper 2 cell differentiation)|go:"GO:0045920"(negative regulation of exocytosis)|go:"GO:0046632"(alpha-beta T cell differentiation)|ensembl:ENSG00000135046(gene)|ensembl:ENST00000257497(transcript)|ensembl:ENST00000376911(transcript)|go:"GO:0001533"(cornified envelope)|go:"GO:0001780"(neutrophil homeostasis)|go:"GO:0001891"(phagocytic cup)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002685"(regulation of leukocyte migration)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005544"(calcium-dependent phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006909"(phagocytosis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009986"(cell surface)|go:"GO:0010165"(response to X-ray)|go:"GO:0014839"(myoblast migration involved in skeletal muscle regeneration)|go:"GO:0016323"(basolateral plasma membrane)|refseq:XP_011516911.1|dip:DIP-32875N|go:"GO:0046883"(regulation of hormone secretion)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070365"(hepatocyte differentiation)|go:"GO:0070459"(prolactin secretion)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0071385"(cellular response to glucocorticoid stimulus)|go:"GO:0071621"(granulocyte chemotaxis)|go:"GO:0090050"(positive regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097350"(neutrophil clearance)|go:"GO:0098641"(cadherin binding involved in cell-cell adhesion)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1900138"(negative regulation of phospholipase A2 activity)|go:"GO:1990814"(DNA/DNA annealing activity)|interpro:IPR001464(Annexin)|interpro:IPR002388(Annexin, type I)|interpro:IPR018252|interpro:IPR018502|interpro:IPR037104|mint:P04083|rcsb pdb:1AIN|rcsb pdb:1BO9|rcsb pdb:1QLS|rcsb pdb:5VFW|reactome:R-HSA-416476|reactome:R-HSA-418594|reactome:R-HSA-444473|reactome:R-HSA-445355|reactome:R-HSA-6785807|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0050482"(arachidonic acid secretion)|go:"GO:0050709"(negative regulation of protein secretion)|go:"GO:0050727"(regulation of inflammatory response) psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2020/03/02 rogid:k1f34cDGMScg/+VAP4YpR62Hrto9606 rogid:QKmqz+UsAof35B/so2qKLQjn2v09606 intact-crc:AD067DE087BA5193|rigid:pWC1ZuzM781wqc5We0UPHExeUbQ false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q5W0Q7 intact:EBI-2513915 intact:EBI-2513899|ensembl:ENSP00000255304|uniprotkb:Q8IYE8|uniprotkb:Q6AI45|uniprotkb:Q14109|uniprotkb:Q8IY30 - psi-mi:uspl1_human(display_long)|uniprotkb:Ubiquitin-specific peptidase-like protein 1(gene name synonym)|uniprotkb:USPL1(gene name)|psi-mi:USPL1(display_short)|uniprotkb:C13orf22(gene name synonym)|uniprotkb:D13S106(gene name synonym) psi-mi:c9jam6_human(display_short)|psi-mi:EBI-2513915(display_long)|uniprotkb:IGHA1(gene name)|psi-mi:IGHA1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513897|imex:IM-12079-87 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000132952(gene)|ensembl:ENST00000255304(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009301"(snRNA transcription)|go:"GO:0015030"(Cajal body)|go:"GO:0016926"(protein desumoylation)|go:"GO:0030576"(Cajal body organization)|go:"GO:0032183"(SUMO binding)|go:"GO:0070140"(SUMO-specific isopeptidase activity)|interpro:IPR028889|interpro:IPR028890|interpro:IPR029388|interpro:IPR033505|interpro:IPR038765|refseq:NP_005791.3|refseq:NP_001308461.1|refseq:NP_001308462.1|refseq:NP_001308463.1|refseq:XP_005266270.1|dip:DIP-47278N uniprotkb:C9JAM6(uniprot-removed-ac) psi-mi:"MI:0469"(intact) - no-uniprot-update:|caution:The sequence has been withdrawn from uniprot. figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2020/03/02 rogid:k1f34cDGMScg/+VAP4YpR62Hrto9606 rogid:euCK1aQDNMxf9lJH3UeejXBDJSE9606 intact-crc:AD067DE087BA5193|rigid:pWC1ZuzM781wqc5We0UPHExeUbQ false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q5W0Q7 uniprotkb:P78386 intact:EBI-2513899|ensembl:ENSP00000255304|uniprotkb:Q8IYE8|uniprotkb:Q6AI45|uniprotkb:Q14109|uniprotkb:Q8IY30 intact:EBI-1049371|uniprotkb:Q9NSB1|ensembl:ENSP00000257901 psi-mi:uspl1_human(display_long)|uniprotkb:Ubiquitin-specific peptidase-like protein 1(gene name synonym)|uniprotkb:USPL1(gene name)|psi-mi:USPL1(display_short)|uniprotkb:C13orf22(gene name synonym)|uniprotkb:D13S106(gene name synonym) psi-mi:krt85_human(display_long)|uniprotkb:Type II hair keratin Hb5(gene name synonym)|uniprotkb:Keratin-85(gene name synonym)|uniprotkb:Hair keratin K2.12(gene name synonym)|uniprotkb:KRT85(gene name)|psi-mi:KRT85(display_short)|uniprotkb:KRTHB5(gene name synonym)|uniprotkb:Type-II keratin Kb25(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513897|imex:IM-12079-87 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000132952(gene)|ensembl:ENST00000255304(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009301"(snRNA transcription)|go:"GO:0015030"(Cajal body)|go:"GO:0016926"(protein desumoylation)|go:"GO:0030576"(Cajal body organization)|go:"GO:0032183"(SUMO binding)|go:"GO:0070140"(SUMO-specific isopeptidase activity)|interpro:IPR028889|interpro:IPR028890|interpro:IPR029388|interpro:IPR033505|interpro:IPR038765|refseq:NP_005791.3|refseq:NP_001308461.1|refseq:NP_001308462.1|refseq:NP_001308463.1|refseq:XP_005266270.1|dip:DIP-47278N refseq:NP_001287739.1|refseq:NP_002274.1|ensembl:ENSG00000135443(gene)|ensembl:ENST00000257901(transcript)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005829"(cytosol)|go:"GO:0008544"(epidermis development)|go:"GO:0045095"(keratin filament)|interpro:IPR003054(Type II keratin)|interpro:IPR018039|interpro:IPR032444|interpro:IPR039008|reactome:R-HSA-6805567|reactome:R-HSA-6809371 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2020/03/02 rogid:k1f34cDGMScg/+VAP4YpR62Hrto9606 rogid:O+5NoIWK84IGOos3h32HHMjZE889606 intact-crc:AD067DE087BA5193|rigid:pWC1ZuzM781wqc5We0UPHExeUbQ false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P40818 uniprotkb:Q9UPT9 intact:EBI-1050865|uniprotkb:Q2TB31|uniprotkb:Q7Z3U2|uniprotkb:Q86VA0|uniprotkb:Q8IWI7|ensembl:ENSP00000302239|ensembl:ENSP00000379721|uniprotkb:B4DKA8 intact:EBI-723510|ensembl:ENSP00000261497|uniprotkb:A0JNS3|uniprotkb:Q2NLE2|uniprotkb:Q6MZY4|uniprotkb:Q8TBS8|uniprotkb:Q96IW5 psi-mi:ubp8_human(display_long)|uniprotkb:Ubiquitin-specific-processing protease 8(gene name synonym)|uniprotkb:Deubiquitinating enzyme 8(gene name synonym)|uniprotkb:USP8(gene name)|psi-mi:USP8(display_short)|uniprotkb:KIAA0055(gene name synonym)|uniprotkb:UBPY(gene name synonym)|uniprotkb:Ubiquitin isopeptidase Y(gene name synonym)|uniprotkb:Ubiquitin thioesterase 8(gene name synonym) psi-mi:ubp22_human(display_long)|uniprotkb:Ubiquitin-specific-processing protease 22(gene name synonym)|uniprotkb:Deubiquitinating enzyme 22(gene name synonym)|uniprotkb:USP22(gene name)|psi-mi:USP22(display_short)|uniprotkb:KIAA1063(gene name synonym)|uniprotkb:USP3L(gene name synonym)|uniprotkb:Ubiquitin thioesterase 22(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513960|imex:IM-12079-37 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001122082.1|refseq:NP_005145.3|refseq:NP_001269978.1|refseq:XP_011520495.1|ensembl:ENSG00000138592(gene)|ensembl:ENST00000307179(transcript)|ensembl:ENST00000396444(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007032"(endosome organization)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0030496"(midbody)|go:"GO:0031313"(extrinsic component of endosome membrane)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0043197"(dendritic spine)|go:"GO:0045296"(cadherin binding)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099576"(regulation of protein catabolic process at postsynapse, modulating synaptic transmission)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001763(Rhodanese-like)|interpro:IPR015063(Region of unknown function DUF1873)|interpro:IPR018200|interpro:IPR028889|interpro:IPR036873|interpro:IPR038765|mint:P40818|rcsb pdb:1WHB|rcsb pdb:2A9U|rcsb pdb:2GFO|rcsb pdb:2GWF|rcsb pdb:3N3K|rcsb pdb:6F09|reactome:R-HSA-1358803|reactome:R-HSA-4641263|reactome:R-HSA-5689880|reactome:R-HSA-6807004|refseq:XP_006720824.1|dip:DIP-40365N refseq:NP_056091.1|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR018200|go:"GO:0007049"(cell cycle)|interpro:IPR028889|interpro:IPR038765|mint:Q9UPT9|go:"GO:0008270"(zinc ion binding)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|reactome:R-HSA-3214847|go:"GO:0016574"(histone ubiquitination)|go:"GO:0016578"(histone deubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019899"(enzyme binding)|reactome:R-HSA-5689880|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0043967"(histone H4 acetylation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|ensembl:ENSG00000124422(gene)|ensembl:ENST00000261497(transcript)|go:"GO:0000124"(SAGA complex)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process) psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:hpBBzyA4lc9is80ZFJBr1fyEyOM9606 rogid:8n1lOTC7I8dP3RY1IEUtIkJiSXc9606 intact-crc:5C4656C2EF8D8200|rigid:B4V+Ax+JFexwRRW5vwa9yOaaL+A false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P40818 uniprotkb:Q15323 intact:EBI-1050865|uniprotkb:Q2TB31|uniprotkb:Q7Z3U2|uniprotkb:Q86VA0|uniprotkb:Q8IWI7|ensembl:ENSP00000302239|ensembl:ENSP00000379721|uniprotkb:B4DKA8 intact:EBI-948001|uniprotkb:Q9UE12|ensembl:ENSP00000251645|ensembl:ENSP00000460739 psi-mi:ubp8_human(display_long)|uniprotkb:Ubiquitin-specific-processing protease 8(gene name synonym)|uniprotkb:Deubiquitinating enzyme 8(gene name synonym)|uniprotkb:USP8(gene name)|psi-mi:USP8(display_short)|uniprotkb:KIAA0055(gene name synonym)|uniprotkb:UBPY(gene name synonym)|uniprotkb:Ubiquitin isopeptidase Y(gene name synonym)|uniprotkb:Ubiquitin thioesterase 8(gene name synonym) psi-mi:k1h1_human(display_long)|uniprotkb:Hair keratin, type I Ha1(gene name synonym)|uniprotkb:Keratin-31(gene name synonym)|uniprotkb:KRT31(gene name)|psi-mi:KRT31(display_short)|uniprotkb:HHA1(gene name synonym)|uniprotkb:HKA1(gene name synonym)|uniprotkb:KRTHA1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513960|imex:IM-12079-37 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001122082.1|refseq:NP_005145.3|refseq:NP_001269978.1|refseq:XP_011520495.1|ensembl:ENSG00000138592(gene)|ensembl:ENST00000307179(transcript)|ensembl:ENST00000396444(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007032"(endosome organization)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0030496"(midbody)|go:"GO:0031313"(extrinsic component of endosome membrane)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0043197"(dendritic spine)|go:"GO:0045296"(cadherin binding)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099576"(regulation of protein catabolic process at postsynapse, modulating synaptic transmission)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001763(Rhodanese-like)|interpro:IPR015063(Region of unknown function DUF1873)|interpro:IPR018200|interpro:IPR028889|interpro:IPR036873|interpro:IPR038765|mint:P40818|rcsb pdb:1WHB|rcsb pdb:2A9U|rcsb pdb:2GFO|rcsb pdb:2GWF|rcsb pdb:3N3K|rcsb pdb:6F09|reactome:R-HSA-1358803|reactome:R-HSA-4641263|reactome:R-HSA-5689880|reactome:R-HSA-6807004|refseq:XP_006720824.1|dip:DIP-40365N refseq:NP_002268.2|ensembl:ENSG00000094796(gene)|ensembl:ENSG00000262993(gene)|ensembl:ENST00000251645(transcript)|ensembl:ENST00000573281(transcript)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005615"(extracellular space)|go:"GO:0005829"(cytosol)|go:"GO:0005882"(intermediate filament)|go:"GO:0008544"(epidermis development)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002957(Keratin, type I)|interpro:IPR018039|interpro:IPR039008|reactome:R-HSA-6805567|reactome:R-HSA-6809371 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:hpBBzyA4lc9is80ZFJBr1fyEyOM9606 rogid:ur97LEvtqaqu3wh7iaX4HhN163k9606 intact-crc:5C4656C2EF8D8200|rigid:B4V+Ax+JFexwRRW5vwa9yOaaL+A false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P40818 uniprotkb:O76013 intact:EBI-1050865|uniprotkb:Q2TB31|uniprotkb:Q7Z3U2|uniprotkb:Q86VA0|uniprotkb:Q8IWI7|ensembl:ENSP00000302239|ensembl:ENSP00000379721|uniprotkb:B4DKA8 intact:EBI-1054946|uniprotkb:Q86XG4|ensembl:ENSP00000329165 psi-mi:ubp8_human(display_long)|uniprotkb:Ubiquitin-specific-processing protease 8(gene name synonym)|uniprotkb:Deubiquitinating enzyme 8(gene name synonym)|uniprotkb:USP8(gene name)|psi-mi:USP8(display_short)|uniprotkb:KIAA0055(gene name synonym)|uniprotkb:UBPY(gene name synonym)|uniprotkb:Ubiquitin isopeptidase Y(gene name synonym)|uniprotkb:Ubiquitin thioesterase 8(gene name synonym) psi-mi:krt36_human(display_long)|uniprotkb:KRTHA6(gene name synonym)|uniprotkb:Hair keratin, type I Ha6(gene name synonym)|uniprotkb:Keratin-36(gene name synonym)|uniprotkb:KRT36(gene name)|psi-mi:KRT36(display_short)|uniprotkb:HHA6(gene name synonym)|uniprotkb:HKA6(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513960|imex:IM-12079-37 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001122082.1|refseq:NP_005145.3|refseq:NP_001269978.1|refseq:XP_011520495.1|ensembl:ENSG00000138592(gene)|ensembl:ENST00000307179(transcript)|ensembl:ENST00000396444(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007032"(endosome organization)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0030496"(midbody)|go:"GO:0031313"(extrinsic component of endosome membrane)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0043197"(dendritic spine)|go:"GO:0045296"(cadherin binding)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099576"(regulation of protein catabolic process at postsynapse, modulating synaptic transmission)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001763(Rhodanese-like)|interpro:IPR015063(Region of unknown function DUF1873)|interpro:IPR018200|interpro:IPR028889|interpro:IPR036873|interpro:IPR038765|mint:P40818|rcsb pdb:1WHB|rcsb pdb:2A9U|rcsb pdb:2GFO|rcsb pdb:2GWF|rcsb pdb:3N3K|rcsb pdb:6F09|reactome:R-HSA-1358803|reactome:R-HSA-4641263|reactome:R-HSA-5689880|reactome:R-HSA-6807004|refseq:XP_006720824.1|dip:DIP-40365N refseq:NP_003762.1|ensembl:ENSG00000126337(gene)|ensembl:ENST00000328119(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005882"(intermediate filament)|go:"GO:0030280"(structural constituent of skin epidermis)|go:"GO:0045616"(regulation of keratinocyte differentiation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002957(Keratin, type I)|interpro:IPR018039|interpro:IPR039008|reactome:R-HSA-6805567|reactome:R-HSA-6809371 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:hpBBzyA4lc9is80ZFJBr1fyEyOM9606 rogid:T3L08n7jEhsouGDkQuK0jBLanBQ9606 intact-crc:5C4656C2EF8D8200|rigid:B4V+Ax+JFexwRRW5vwa9yOaaL+A false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P40818 intact:EBI-2509386 intact:EBI-1050865|uniprotkb:Q2TB31|uniprotkb:Q7Z3U2|uniprotkb:Q86VA0|uniprotkb:Q8IWI7|ensembl:ENSP00000302239|ensembl:ENSP00000379721|uniprotkb:B4DKA8 uniparc:UPI0000DD78B9 psi-mi:ubp8_human(display_long)|uniprotkb:Ubiquitin-specific-processing protease 8(gene name synonym)|uniprotkb:Deubiquitinating enzyme 8(gene name synonym)|uniprotkb:USP8(gene name)|psi-mi:USP8(display_short)|uniprotkb:KIAA0055(gene name synonym)|uniprotkb:UBPY(gene name synonym)|uniprotkb:Ubiquitin isopeptidase Y(gene name synonym)|uniprotkb:Ubiquitin thioesterase 8(gene name synonym) psi-mi:ipi00455427(display_short)|psi-mi:EBI-2509386(display_long) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513960|imex:IM-12079-37 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001122082.1|refseq:NP_005145.3|refseq:NP_001269978.1|refseq:XP_011520495.1|ensembl:ENSG00000138592(gene)|ensembl:ENST00000307179(transcript)|ensembl:ENST00000396444(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007032"(endosome organization)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0030496"(midbody)|go:"GO:0031313"(extrinsic component of endosome membrane)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0043197"(dendritic spine)|go:"GO:0045296"(cadherin binding)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099576"(regulation of protein catabolic process at postsynapse, modulating synaptic transmission)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001763(Rhodanese-like)|interpro:IPR015063(Region of unknown function DUF1873)|interpro:IPR018200|interpro:IPR028889|interpro:IPR036873|interpro:IPR038765|mint:P40818|rcsb pdb:1WHB|rcsb pdb:2A9U|rcsb pdb:2GFO|rcsb pdb:2GWF|rcsb pdb:3N3K|rcsb pdb:6F09|reactome:R-HSA-1358803|reactome:R-HSA-4641263|reactome:R-HSA-5689880|reactome:R-HSA-6807004|refseq:XP_006720824.1|dip:DIP-40365N - psi-mi:"MI:0469"(intact) - no-uniprot-update:An amino acid sequence which is not represented in UniProt figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:hpBBzyA4lc9is80ZFJBr1fyEyOM9606 rogid:TqeMY2L6a5nopo9mvg/ayKhEtDU9606 intact-crc:5C4656C2EF8D8200|rigid:B4V+Ax+JFexwRRW5vwa9yOaaL+A false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P40818 uniprotkb:P78386 intact:EBI-1050865|uniprotkb:Q2TB31|uniprotkb:Q7Z3U2|uniprotkb:Q86VA0|uniprotkb:Q8IWI7|ensembl:ENSP00000302239|ensembl:ENSP00000379721|uniprotkb:B4DKA8 intact:EBI-1049371|uniprotkb:Q9NSB1|ensembl:ENSP00000257901 psi-mi:ubp8_human(display_long)|uniprotkb:Ubiquitin-specific-processing protease 8(gene name synonym)|uniprotkb:Deubiquitinating enzyme 8(gene name synonym)|uniprotkb:USP8(gene name)|psi-mi:USP8(display_short)|uniprotkb:KIAA0055(gene name synonym)|uniprotkb:UBPY(gene name synonym)|uniprotkb:Ubiquitin isopeptidase Y(gene name synonym)|uniprotkb:Ubiquitin thioesterase 8(gene name synonym) psi-mi:krt85_human(display_long)|uniprotkb:Type II hair keratin Hb5(gene name synonym)|uniprotkb:Keratin-85(gene name synonym)|uniprotkb:Hair keratin K2.12(gene name synonym)|uniprotkb:KRT85(gene name)|psi-mi:KRT85(display_short)|uniprotkb:KRTHB5(gene name synonym)|uniprotkb:Type-II keratin Kb25(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513960|imex:IM-12079-37 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001122082.1|refseq:NP_005145.3|refseq:NP_001269978.1|refseq:XP_011520495.1|ensembl:ENSG00000138592(gene)|ensembl:ENST00000307179(transcript)|ensembl:ENST00000396444(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007032"(endosome organization)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0030496"(midbody)|go:"GO:0031313"(extrinsic component of endosome membrane)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0043197"(dendritic spine)|go:"GO:0045296"(cadherin binding)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099576"(regulation of protein catabolic process at postsynapse, modulating synaptic transmission)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001763(Rhodanese-like)|interpro:IPR015063(Region of unknown function DUF1873)|interpro:IPR018200|interpro:IPR028889|interpro:IPR036873|interpro:IPR038765|mint:P40818|rcsb pdb:1WHB|rcsb pdb:2A9U|rcsb pdb:2GFO|rcsb pdb:2GWF|rcsb pdb:3N3K|rcsb pdb:6F09|reactome:R-HSA-1358803|reactome:R-HSA-4641263|reactome:R-HSA-5689880|reactome:R-HSA-6807004|refseq:XP_006720824.1|dip:DIP-40365N refseq:NP_001287739.1|refseq:NP_002274.1|ensembl:ENSG00000135443(gene)|ensembl:ENST00000257901(transcript)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005829"(cytosol)|go:"GO:0008544"(epidermis development)|go:"GO:0045095"(keratin filament)|interpro:IPR003054(Type II keratin)|interpro:IPR018039|interpro:IPR032444|interpro:IPR039008|reactome:R-HSA-6805567|reactome:R-HSA-6809371 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:hpBBzyA4lc9is80ZFJBr1fyEyOM9606 rogid:O+5NoIWK84IGOos3h32HHMjZE889606 intact-crc:5C4656C2EF8D8200|rigid:B4V+Ax+JFexwRRW5vwa9yOaaL+A false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q4VCS5 uniprotkb:P46937 intact:EBI-2511319|ensembl:ENSP00000361027|uniprotkb:Q504X5|uniprotkb:Q9UPT1|uniprotkb:Q9HD27 intact:EBI-1044059|uniprotkb:Q7Z574|uniprotkb:Q8IUY9|ensembl:ENSP00000282441|intact:EBI-28992622|uniprotkb:B7ZA01|uniprotkb:E3WEB5|uniprotkb:E3WEB6|uniprotkb:E9PRV2|uniprotkb:F5H202|uniprotkb:K0KQ18|uniprotkb:K0KYZ8|uniprotkb:K0L195|uniprotkb:K0L1G3|uniprotkb:B4DTY1 psi-mi:amot_human(display_long)|uniprotkb:AMOT(gene name)|psi-mi:AMOT(display_short)|uniprotkb:KIAA1071(gene name synonym) psi-mi:yap1_human(display_long)|uniprotkb:YAP1(gene name)|psi-mi:YAP1(display_short)|uniprotkb:YAP65(gene name synonym)|uniprotkb:Protein yorkie homolog(gene name synonym)|uniprotkb:Yes-associated protein YAP65 homolog(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513986|imex:IM-12079-88 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000126016(gene)|ensembl:ENST00000371959(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0001725"(stress fiber)|go:"GO:0001726"(ruffle)|go:"GO:0003365"(establishment of cell polarity involved in ameboidal cell migration)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006935"(chemotaxis)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030054"(cell junction)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035329"(hippo signaling)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0040019"(positive regulation of embryonic development)|go:"GO:0042074"(cell migration involved in gastrulation)|go:"GO:0043116"(negative regulation of vascular permeability)|go:"GO:0043532"(angiostatin binding)|go:"GO:0043534"(blood vessel endothelial cell migration)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0051496"(positive regulation of stress fiber assembly)|interpro:IPR009114(Angiomotin)|interpro:IPR024646|mint:Q4VCS5|rcsb pdb:6JJX|reactome:R-HSA-2028269|refseq:XP_011529177.1|refseq:NP_001106962.1|refseq:NP_573572.1|refseq:XP_005262144.1|refseq:XP_005262147.1|refseq:XP_016884778.1|dip:DIP-53711N refseq:NP_001269026.1|ensembl:ENST00000282441(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001674"(female germ cell nucleus)|go:"GO:0001829"(trophectodermal cell differentiation)|go:"GO:0001894"(tissue homeostasis)|go:"GO:0003015"(heart process)|go:"GO:0003143"(embryonic heart tube morphogenesis)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|ensembl:ENSG00000137693(gene)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010837"(regulation of keratinocyte proliferation)|go:"GO:0016020"(membrane)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030857"(negative regulation of epithelial cell differentiation)|go:"GO:0030903"(notochord development)|go:"GO:0032570"(response to progesterone)|go:"GO:0033148"(positive regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0035329"(hippo signaling)|go:"GO:0042060"(wound healing)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0005634"(nucleus)|go:"GO:0048339"(paraxial mesoderm development)|go:"GO:0048368"(lateral mesoderm development)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0050847"(progesterone receptor signaling pathway)|refseq:NP_001123617.1|refseq:NP_001181973.1|refseq:NP_001181974.1|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0072091"(regulation of stem cell proliferation)|go:"GO:0072307"(regulation of metanephric nephron tubule epithelial cell differentiation)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:0140552"(TEAD-YAP complex)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1902018"(negative regulation of cilium assembly)|go:"GO:1902459"(positive regulation of stem cell population maintenance)|go:"GO:1904036"(negative regulation of epithelial cell apoptotic process)|go:"GO:2000737"(negative regulation of stem cell differentiation)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR036020|mint:P46937|rcsb pdb:1JMQ|rcsb pdb:1K5R|rcsb pdb:1K9Q|rcsb pdb:1K9R|rcsb pdb:2LAW|rcsb pdb:2LAX|rcsb pdb:2LAY|rcsb pdb:2LTV|rcsb pdb:2LTW|rcsb pdb:3KYS|rcsb pdb:3MHR|rcsb pdb:4RE1|rcsb pdb:4REX|rcsb pdb:5OAQ|rcsb pdb:5YDX|rcsb pdb:5YDY|rcsb pdb:6G6X|rcsb pdb:6G8I|rcsb pdb:6G8J|rcsb pdb:6G8K|rcsb pdb:6G8L|rcsb pdb:6G8P|rcsb pdb:6G8Q|rcsb pdb:6GE3|rcsb pdb:6GE4|rcsb pdb:6GE5|rcsb pdb:6GE6|rcsb pdb:6GEC|rcsb pdb:6GEE|rcsb pdb:6GEG|go:"GO:0070064"(proline-rich region binding)|rcsb pdb:6GEI|rcsb pdb:6GEK|rcsb pdb:6HIK|rcsb pdb:6HIL|rcsb pdb:6Q2X|reactome:R-HSA-1251985|reactome:R-HSA-2028269|reactome:R-HSA-2032785|reactome:R-HSA-8939236|reactome:R-HSA-8940973|reactome:R-HSA-8951671|reactome:R-HSA-9619665|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060242"(contact inhibition)|go:"GO:0060449"(bud elongation involved in lung branching)|go:"GO:0060487"(lung epithelial cell differentiation)|go:"GO:0060576"(intestinal epithelial cell development)|go:"GO:0061026"(cardiac muscle tissue regeneration)|go:"GO:0065003"(protein-containing complex assembly)|ensembl:ENSP00000282441|ensembl:ENST00000345877|ensembl:ENSP00000331023|ensembl:ENST00000524575|ensembl:ENSP00000435602|ensembl:ENST00000526343|refseq:NP_001269027.1|refseq:NP_001269028.1|refseq:NP_001269029.1|refseq:NP_001269030.1|ensembl:ENSP00000434134|ensembl:ENST00000531439|ensembl:ENSP00000431574|ensembl:ENSP00000487519|ensembl:ENST00000537274|ensembl:ENSP00000445635|ensembl:ENST00000615667|ensembl:ENSP00000478927|ensembl:ENST00000629586|dip:DIP-40839N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2017/12/08 rogid:5O9K+GgX1s0Hn5optTeKPOs+X1s9606 rogid:bDNDhtCh5Qjdk1+PNM8Qb/340A09606 intact-crc:B8C71821CF47A8CE|rigid:BtNIzIp7f0+26GViCLFcZM2s1ic false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q4VCS5 uniprotkb:Q9NUP9 intact:EBI-2511319|ensembl:ENSP00000361027|uniprotkb:Q504X5|uniprotkb:Q9UPT1|uniprotkb:Q9HD27 intact:EBI-1171517|ensembl:ENSP00000278193 psi-mi:amot_human(display_long)|uniprotkb:AMOT(gene name)|psi-mi:AMOT(display_short)|uniprotkb:KIAA1071(gene name synonym) psi-mi:lin7c_human(display_long)|uniprotkb:Mammalian lin-seven protein 3(gene name synonym)|uniprotkb:Vertebrate lin-7 homolog 3(gene name synonym)|uniprotkb:LIN7C(gene name)|psi-mi:LIN7C(display_short)|uniprotkb:MALS3(gene name synonym)|uniprotkb:VELI3(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513986|imex:IM-12079-88 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000126016(gene)|ensembl:ENST00000371959(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0001725"(stress fiber)|go:"GO:0001726"(ruffle)|go:"GO:0003365"(establishment of cell polarity involved in ameboidal cell migration)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006935"(chemotaxis)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030054"(cell junction)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035329"(hippo signaling)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0040019"(positive regulation of embryonic development)|go:"GO:0042074"(cell migration involved in gastrulation)|go:"GO:0043116"(negative regulation of vascular permeability)|go:"GO:0043532"(angiostatin binding)|go:"GO:0043534"(blood vessel endothelial cell migration)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0051496"(positive regulation of stress fiber assembly)|interpro:IPR009114(Angiomotin)|interpro:IPR024646|mint:Q4VCS5|rcsb pdb:6JJX|reactome:R-HSA-2028269|refseq:XP_011529177.1|refseq:NP_001106962.1|refseq:NP_573572.1|refseq:XP_005262144.1|refseq:XP_005262147.1|refseq:XP_016884778.1|dip:DIP-53711N refseq:NP_060832.1|ensembl:ENSG00000148943(gene)|ensembl:ENST00000278193(transcript)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006887"(exocytosis)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0015031"(protein transport)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0045199"(maintenance of epithelial cell apical/basal polarity)|go:"GO:0045202"(synapse)|go:"GO:0097016"(L27 domain binding)|go:"GO:0097025"(MPP7-DLG1-LIN7 complex)|go:"GO:0098793"(presynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1903361"(protein localization to basolateral plasma membrane)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR004172(L27)|interpro:IPR014775(L27, C-terminal)|interpro:IPR017365(Lin-7 homologue)|interpro:IPR036034|interpro:IPR036892|mint:Q9NUP9|rcsb pdb:3LRA|reactome:R-HSA-212676|reactome:R-HSA-6794361|reactome:R-HSA-9609736 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2017/12/08 rogid:5O9K+GgX1s0Hn5optTeKPOs+X1s9606 rogid:F2rasaJ64Olc9qScN79LJRqsUEE9606 intact-crc:B8C71821CF47A8CE|rigid:BtNIzIp7f0+26GViCLFcZM2s1ic false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q4VCS5 uniprotkb:Q5T2T1 intact:EBI-2511319|ensembl:ENSP00000361027|uniprotkb:Q504X5|uniprotkb:Q9UPT1|uniprotkb:Q9HD27 intact:EBI-2514004|ensembl:ENSP00000337907|ensembl:ENSP00000364871|ensembl:ENSP00000364884|ensembl:ENSP00000507917|uniprotkb:B2RCC9|uniprotkb:Q5T2T0|uniprotkb:B5MDZ3|uniprotkb:Q8IY28|uniprotkb:B4DWL9|uniprotkb:D3DRW3 psi-mi:amot_human(display_long)|uniprotkb:AMOT(gene name)|psi-mi:AMOT(display_short)|uniprotkb:KIAA1071(gene name synonym) psi-mi:mpp7_human(display_long)|uniprotkb:MPP7(gene name)|psi-mi:MPP7(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513986|imex:IM-12079-88 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000126016(gene)|ensembl:ENST00000371959(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0001725"(stress fiber)|go:"GO:0001726"(ruffle)|go:"GO:0003365"(establishment of cell polarity involved in ameboidal cell migration)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006935"(chemotaxis)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030054"(cell junction)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035329"(hippo signaling)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0040019"(positive regulation of embryonic development)|go:"GO:0042074"(cell migration involved in gastrulation)|go:"GO:0043116"(negative regulation of vascular permeability)|go:"GO:0043532"(angiostatin binding)|go:"GO:0043534"(blood vessel endothelial cell migration)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0051496"(positive regulation of stress fiber assembly)|interpro:IPR009114(Angiomotin)|interpro:IPR024646|mint:Q4VCS5|rcsb pdb:6JJX|reactome:R-HSA-2028269|refseq:XP_011529177.1|refseq:NP_001106962.1|refseq:NP_573572.1|refseq:XP_005262144.1|refseq:XP_005262147.1|refseq:XP_016884778.1|dip:DIP-53711N ensembl:ENSG00000150054(gene)|ensembl:ENST00000337532(transcript)|ensembl:ENST00000375719(transcript)|ensembl:ENST00000375732(transcript)|ensembl:ENST00000683449(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0005938"(cell cortex)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030054"(cell junction)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0045296"(cadherin binding)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0071896"(protein localization to adherens junction)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR004172(L27)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR014775(L27, C-terminal)|interpro:IPR020590|interpro:IPR027417|interpro:IPR035599|interpro:IPR036028|interpro:IPR036034|interpro:IPR036892|mint:Q5T2T1|rcsb pdb:3LRA|rcsb pdb:3O46|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013406|reactome:R-HSA-9013408|go:"GO:0097025"(MPP7-DLG1-LIN7 complex)|reactome:R-HSA-9013409|reactome:R-HSA-9013423|refseq:XP_011517639.1|refseq:NP_001305099.1|refseq:NP_775767.2 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2017/12/08 rogid:5O9K+GgX1s0Hn5optTeKPOs+X1s9606 rogid:QYVCkD5zsnTsCd7YsYsbQY8L7fU9606 intact-crc:B8C71821CF47A8CE|rigid:BtNIzIp7f0+26GViCLFcZM2s1ic false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q4VCS5 uniprotkb:Q8N3R9 intact:EBI-2511319|ensembl:ENSP00000361027|uniprotkb:Q504X5|uniprotkb:Q9UPT1|uniprotkb:Q9HD27 intact:EBI-2513978|ensembl:ENSP00000261681|ensembl:ENSP00000503321|ensembl:ENSP00000503322|ensembl:ENSP00000503517|ensembl:ENSP00000503713|uniprotkb:Q86T98|uniprotkb:Q8N7I5|uniprotkb:Q7Z631|uniprotkb:Q9H9Q0|uniprotkb:A1L380 psi-mi:amot_human(display_long)|uniprotkb:AMOT(gene name)|psi-mi:AMOT(display_short)|uniprotkb:KIAA1071(gene name synonym) psi-mi:pals1_human(display_long)|uniprotkb:PALS1(gene name)|psi-mi:PALS1(display_short)|uniprotkb:MAGUK p55 subfamily member 5(gene name synonym)|uniprotkb:MPP5(gene name synonym)|uniprotkb:Membrane protein, palmitoylated 5(gene name synonym)|uniprotkb:Protein associated with Lin-7 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513986|imex:IM-12079-88 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000126016(gene)|ensembl:ENST00000371959(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0001725"(stress fiber)|go:"GO:0001726"(ruffle)|go:"GO:0003365"(establishment of cell polarity involved in ameboidal cell migration)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006935"(chemotaxis)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030054"(cell junction)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035329"(hippo signaling)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0040019"(positive regulation of embryonic development)|go:"GO:0042074"(cell migration involved in gastrulation)|go:"GO:0043116"(negative regulation of vascular permeability)|go:"GO:0043532"(angiostatin binding)|go:"GO:0043534"(blood vessel endothelial cell migration)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0051496"(positive regulation of stress fiber assembly)|interpro:IPR009114(Angiomotin)|interpro:IPR024646|mint:Q4VCS5|rcsb pdb:6JJX|reactome:R-HSA-2028269|refseq:XP_011529177.1|refseq:NP_001106962.1|refseq:NP_573572.1|refseq:XP_005262144.1|refseq:XP_005262147.1|refseq:XP_016884778.1|dip:DIP-53711N go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0010467"(gene expression)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021954"(central nervous system neuron development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030424"(axon)|go:"GO:0032287"(peripheral nervous system myelin maintenance)|go:"GO:0032288"(myelin assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035749"(myelin sheath adaxonal region)|go:"GO:0035750"(protein localization to myelin sheath abaxonal region)|go:"GO:0043204"(perikaryon)|go:"GO:0043219"(lateral loop)|go:"GO:0043220"(Schmidt-Lanterman incisure)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR004172(L27)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR014775(L27, C-terminal)|interpro:IPR015145(L27-N)|interpro:IPR020590|interpro:IPR027417|interpro:IPR035601|interpro:IPR036028|interpro:IPR036034|interpro:IPR036892|mint:Q8N3R9|rcsb pdb:1Y76|rcsb pdb:3UIT|rcsb pdb:4UU5|rcsb pdb:4UU6|rcsb pdb:4WSI|rcsb pdb:7M4R|rcsb pdb:7NTJ|rcsb pdb:7NTK|reactome:R-HSA-420029|ensembl:ENSG00000072415(gene)|ensembl:ENST00000261681(transcript)|ensembl:ENST00000676464(transcript)|ensembl:ENST00000677382(transcript)|ensembl:ENST00000677835(transcript)|ensembl:ENST00000678380(transcript)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|refseq:XP_011535388.1|refseq:XP_011535389.1|refseq:NP_071919.2|refseq:NP_001243479.1|refseq:XP_005268060.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2017/12/08 rogid:5O9K+GgX1s0Hn5optTeKPOs+X1s9606 rogid:VpQVKlVcuBSs8mztUd9iHqkIXDM9606 intact-crc:B8C71821CF47A8CE|rigid:BtNIzIp7f0+26GViCLFcZM2s1ic false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q4VCS5 uniprotkb:Q01167 intact:EBI-2511319|ensembl:ENSP00000361027|uniprotkb:Q504X5|uniprotkb:Q9UPT1|uniprotkb:Q9HD27 intact:EBI-2509991|intact:EBI-28976610|ensembl:ENSP00000335677|uniprotkb:Q13624|uniprotkb:Q13623|uniprotkb:A6NEP5|uniprotkb:Q13622 psi-mi:amot_human(display_long)|uniprotkb:AMOT(gene name)|psi-mi:AMOT(display_short)|uniprotkb:KIAA1071(gene name synonym) psi-mi:foxk2_human(display_long)|uniprotkb:G/T-mismatch specific binding protein(gene name synonym)|uniprotkb:FOXK2(gene name)|psi-mi:FOXK2(display_short)|uniprotkb:ILF(gene name synonym)|uniprotkb:ILF1(gene name synonym)|uniprotkb:Interleukin enhancer-binding factor 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513986|imex:IM-12079-88 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000126016(gene)|ensembl:ENST00000371959(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0001725"(stress fiber)|go:"GO:0001726"(ruffle)|go:"GO:0003365"(establishment of cell polarity involved in ameboidal cell migration)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006935"(chemotaxis)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030054"(cell junction)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035329"(hippo signaling)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0040019"(positive regulation of embryonic development)|go:"GO:0042074"(cell migration involved in gastrulation)|go:"GO:0043116"(negative regulation of vascular permeability)|go:"GO:0043532"(angiostatin binding)|go:"GO:0043534"(blood vessel endothelial cell migration)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0051496"(positive regulation of stress fiber assembly)|interpro:IPR009114(Angiomotin)|interpro:IPR024646|mint:Q4VCS5|rcsb pdb:6JJX|reactome:R-HSA-2028269|refseq:XP_011529177.1|refseq:NP_001106962.1|refseq:NP_573572.1|refseq:XP_005262144.1|refseq:XP_005262147.1|refseq:XP_016884778.1|dip:DIP-53711N ensembl:ENSG00000141568(gene)|ensembl:ENST00000335255(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010906"(regulation of glucose metabolic process)|go:"GO:0042594"(response to starvation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|interpro:IPR000253(Forkhead-associated)|interpro:IPR001766(Fork head transcription factor)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR018122|go:"GO:0061621"(canonical glycolysis)|interpro:IPR030456|interpro:IPR036388|interpro:IPR036390|mint:Q01167|rcsb pdb:1JXS|rcsb pdb:2C6Y|reactome:R-HSA-5689603|ensembl:ENSP00000335677|ensembl:ENST00000473637|ensembl:ENSP00000436108|refseq:NP_004505.2 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2017/12/08 rogid:5O9K+GgX1s0Hn5optTeKPOs+X1s9606 rogid:mGYtlnM3enVAuU82j5hQ0sui3F49606 intact-crc:B8C71821CF47A8CE|rigid:BtNIzIp7f0+26GViCLFcZM2s1ic false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q4VCS5 uniprotkb:Q12959 intact:EBI-2511319|ensembl:ENSP00000361027|uniprotkb:Q504X5|uniprotkb:Q9UPT1|uniprotkb:Q9HD27 intact:EBI-357481|ensembl:ENSP00000391732|ensembl:ENSP00000407531|ensembl:ENSP00000499437|uniprotkb:Q12958|uniprotkb:A5YKK7|uniprotkb:B7ZMM0|uniprotkb:B9EIQ5|uniprotkb:D3DXB8|uniprotkb:D3DXB9|uniprotkb:B4DGU1|uniprotkb:B4DGZ8|uniprotkb:E7EWL7|uniprotkb:E9PG21 psi-mi:amot_human(display_long)|uniprotkb:AMOT(gene name)|psi-mi:AMOT(display_short)|uniprotkb:KIAA1071(gene name synonym) psi-mi:dlg1_human(display_long)|uniprotkb:DLG1(gene name)|psi-mi:DLG1(display_short)|uniprotkb:Synapse-associated protein 97(gene name synonym)|uniprotkb:hDlg(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513986|imex:IM-12079-88 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000126016(gene)|ensembl:ENST00000371959(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0001725"(stress fiber)|go:"GO:0001726"(ruffle)|go:"GO:0003365"(establishment of cell polarity involved in ameboidal cell migration)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006935"(chemotaxis)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030054"(cell junction)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035329"(hippo signaling)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0040019"(positive regulation of embryonic development)|go:"GO:0042074"(cell migration involved in gastrulation)|go:"GO:0043116"(negative regulation of vascular permeability)|go:"GO:0043532"(angiostatin binding)|go:"GO:0043534"(blood vessel endothelial cell migration)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0051496"(positive regulation of stress fiber assembly)|interpro:IPR009114(Angiomotin)|interpro:IPR024646|mint:Q4VCS5|rcsb pdb:6JJX|reactome:R-HSA-2028269|refseq:XP_011529177.1|refseq:NP_001106962.1|refseq:NP_573572.1|refseq:XP_005262144.1|refseq:XP_005262147.1|refseq:XP_016884778.1|dip:DIP-53711N reactome:R-HSA-9617324|reactome:R-HSA-9620244|ensembl:ENST00000419354(transcript)|ensembl:ENST00000448528(transcript)|ensembl:ENST00000670935(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001771"(immunological synapse formation)|go:"GO:0001772"(immunological synapse)|go:"GO:0001935"(endothelial cell proliferation)|go:"GO:0002088"(lens development in camera-type eye)|ensembl:ENSG00000075711(gene)|go:"GO:0004385"(guanylate kinase activity)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0005604"(basement membrane)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007015"(actin filament organization)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0043113"(receptor clustering)|go:"GO:0043219"(lateral loop)|go:"GO:0043268"(positive regulation of potassium ion transport)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0045296"(cadherin binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048608"(reproductive structure development)|go:"GO:0048704"(embryonic skeletal system morphogenesis)|go:"GO:0043622"(cortical microtubule organization)|go:"GO:0048745"(smooth muscle tissue development)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051660"(establishment of centrosome localization)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0060022"(hard palate development)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097016"(L27 domain binding)|go:"GO:0097025"(MPP7-DLG1-LIN7 complex)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098911"(regulation of ventricular cardiac muscle cell action potential)|go:"GO:0098919"(structural constituent of postsynaptic density)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:1902305"(regulation of sodium ion transmembrane transport)|go:"GO:1902473"(regulation of protein localization to synapse)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903286"(regulation of potassium ion import)|go:"GO:1903753"(negative regulation of p38MAPK cascade)|go:"GO:1903760"(regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization)|go:"GO:1903764"(regulation of potassium ion export across plasma membrane)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR001452(Src homology-3)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045121"(membrane raft)|refseq:NP_001091894.1|refseq:NP_001191315.1|refseq:NP_001191316.1|refseq:NP_001191317.1|refseq:NP_004078.2|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0014704"(intercalated disc)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030432"(peristalsis)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0031253"(cell projection membrane)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031579"(membrane raft organization)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031641"(regulation of myelination)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0033268"(node of Ranvier)|go:"GO:0034629"|go:"GO:0035748"(myelin sheath abaxonal region)|go:"GO:0042110"(T cell activation)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042982"(amyloid precursor protein metabolic process)|go:"GO:0043005"(neuron projection)|interpro:IPR019583|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR019590|interpro:IPR020590|interpro:IPR027417|interpro:IPR036028|interpro:IPR036034|interpro:IPR036892|mint:Q12959|rcsb pdb:1PDR|rcsb pdb:2M3M|rcsb pdb:2OQS|rcsb pdb:2X7Z|rcsb pdb:3LRA|rcsb pdb:3RL7|rcsb pdb:3RL8|rcsb pdb:3W9Y|rcsb pdb:4AMH|rcsb pdb:4G69|reactome:R-HSA-399719|interpro:IPR004172(L27)|interpro:IPR008144(Guanylate kinase)|reactome:R-HSA-438066|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR015143(L27-1)|interpro:IPR016313("Membrane-associated guanylate kinase (MAGUK) scaffold protein")|reactome:R-HSA-442982|reactome:R-HSA-447038|reactome:R-HSA-451308|reactome:R-HSA-5673001|reactome:R-HSA-8849932|reactome:R-HSA-9609736|refseq:XP_011510804.1|refseq:XP_011510807.1|refseq:XP_011510808.1|refseq:XP_005269346.1|refseq:NP_001277912.1|refseq:XP_016861289.1|refseq:XP_016861290.1|refseq:XP_016861291.1|refseq:XP_016861292.1|refseq:XP_016861294.1|refseq:XP_016861295.1|refseq:XP_016861296.1|refseq:XP_016861297.1|refseq:XP_016861298.1|refseq:XP_016861305.1|refseq:XP_016861306.1|refseq:XP_016861307.1|refseq:XP_016861308.1|refseq:XP_016861309.1|dip:DIP-33957N|refseq:XP_011510805.1|refseq:XP_016861299.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2017/12/08 rogid:5O9K+GgX1s0Hn5optTeKPOs+X1s9606 rogid:ax5sUROdL8kF59RhocRWG6tUUkc9606 intact-crc:B8C71821CF47A8CE|rigid:BtNIzIp7f0+26GViCLFcZM2s1ic false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q4VCS5 uniprotkb:Q8N4C6 intact:EBI-2511319|ensembl:ENSP00000361027|uniprotkb:Q504X5|uniprotkb:Q9UPT1|uniprotkb:Q9HD27 intact:EBI-1164022|uniprotkb:Q6P0P6|uniprotkb:Q9BWU6|uniprotkb:Q9C012|uniprotkb:Q9C013|uniprotkb:Q9C014|uniprotkb:Q9H5I6|uniprotkb:Q9HAT7|uniprotkb:Q9HBY5|uniprotkb:Q9HCK7|uniprotkb:Q9UH61|uniprotkb:A6NDB8|uniprotkb:B7WPA3|uniprotkb:C9JSB6|uniprotkb:C9JSG2|uniprotkb:C9JXL2|ensembl:ENSP00000371472|uniprotkb:Q5BKU3 psi-mi:amot_human(display_long)|uniprotkb:AMOT(gene name)|psi-mi:AMOT(display_short)|uniprotkb:KIAA1071(gene name synonym) psi-mi:nin_human(display_long)|uniprotkb:Glycogen synthase kinase 3 beta-interacting protein(gene name synonym)|uniprotkb:NIN(gene name)|psi-mi:NIN(display_short)|uniprotkb:KIAA1565(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513986|imex:IM-12079-88 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000126016(gene)|ensembl:ENST00000371959(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0001725"(stress fiber)|go:"GO:0001726"(ruffle)|go:"GO:0003365"(establishment of cell polarity involved in ameboidal cell migration)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006935"(chemotaxis)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030054"(cell junction)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035329"(hippo signaling)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0040019"(positive regulation of embryonic development)|go:"GO:0042074"(cell migration involved in gastrulation)|go:"GO:0043116"(negative regulation of vascular permeability)|go:"GO:0043532"(angiostatin binding)|go:"GO:0043534"(blood vessel endothelial cell migration)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0051496"(positive regulation of stress fiber assembly)|interpro:IPR009114(Angiomotin)|interpro:IPR024646|mint:Q4VCS5|rcsb pdb:6JJX|reactome:R-HSA-2028269|refseq:XP_011529177.1|refseq:NP_001106962.1|refseq:NP_573572.1|refseq:XP_005262144.1|refseq:XP_005262147.1|refseq:XP_016884778.1|dip:DIP-53711N refseq:XP_011535125.1|ensembl:ENSG00000100503(gene)|ensembl:ENST00000382041(transcript)|go:"GO:0000242"(pericentriolar material)|go:"GO:0000922"(spindle pole)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005813"(centrosome)|refseq:NP_057434.4|refseq:NP_065972.3|refseq:NP_891989.2|refseq:NP_891991.1|go:"GO:0005814"(centriole)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0008104"(protein localization)|go:"GO:0010457"(centriole-centriole cohesion)|go:"GO:0019900"(kinase binding)|go:"GO:0021540"(corpus callosum morphogenesis)|go:"GO:0021957"(corticospinal tract morphogenesis)|go:"GO:0030425"(dendrite)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045177"(apical part of cell)|go:"GO:0048668"(collateral sprouting)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0051011"(microtubule minus-end binding)|go:"GO:0051642"(centrosome localization)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090222"(centrosome-templated microtubule nucleation)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0097539"(ciliary transition fiber)|go:"GO:0120103"(centriolar subdistal appendage)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR029664|mint:Q8N4C6|go:"GO:0034454"(microtubule anchoring at centrosome) psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2017/12/08 rogid:5O9K+GgX1s0Hn5optTeKPOs+X1s9606 rogid:ZvO0amOxGf+HZIxnXTYCqpnzTjw9606 intact-crc:B8C71821CF47A8CE|rigid:BtNIzIp7f0+26GViCLFcZM2s1ic false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q4VCS5 uniprotkb:Q96NL6 intact:EBI-2511319|ensembl:ENSP00000361027|uniprotkb:Q504X5|uniprotkb:Q9UPT1|uniprotkb:Q9HD27 intact:EBI-2514016|ensembl:ENSP00000281142|uniprotkb:Q0VAH2|uniprotkb:A4QN04|uniprotkb:Q6P2M4 psi-mi:amot_human(display_long)|uniprotkb:AMOT(gene name)|psi-mi:AMOT(display_short)|uniprotkb:KIAA1071(gene name synonym) psi-mi:sclt1_human(display_long)|uniprotkb:SCLT1(gene name)|psi-mi:SCLT1(display_short)|uniprotkb:SAP1(gene name synonym)|uniprotkb:Sodium channel-associated protein 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513986|imex:IM-12079-88 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000126016(gene)|ensembl:ENST00000371959(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0001725"(stress fiber)|go:"GO:0001726"(ruffle)|go:"GO:0003365"(establishment of cell polarity involved in ameboidal cell migration)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006935"(chemotaxis)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030054"(cell junction)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035329"(hippo signaling)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0040019"(positive regulation of embryonic development)|go:"GO:0042074"(cell migration involved in gastrulation)|go:"GO:0043116"(negative regulation of vascular permeability)|go:"GO:0043532"(angiostatin binding)|go:"GO:0043534"(blood vessel endothelial cell migration)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0051496"(positive regulation of stress fiber assembly)|interpro:IPR009114(Angiomotin)|interpro:IPR024646|mint:Q4VCS5|rcsb pdb:6JJX|reactome:R-HSA-2028269|refseq:XP_011529177.1|refseq:NP_001106962.1|refseq:NP_573572.1|refseq:XP_005262144.1|refseq:XP_005262147.1|refseq:XP_016884778.1|dip:DIP-53711N ensembl:ENSG00000151466(gene)|ensembl:ENST00000281142(transcript)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0017080"(sodium channel regulator activity)|go:"GO:0030276"(clathrin binding)|go:"GO:0045162"(clustering of voltage-gated sodium channels)|go:"GO:0060271"(cilium assembly)|go:"GO:0071439"(clathrin complex)|go:"GO:0097539"(ciliary transition fiber)|interpro:IPR038911|reactome:R-HSA-5620912|refseq:NP_001287826.1|refseq:NP_001287827.1|refseq:NP_653244.2 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2017/12/08 rogid:5O9K+GgX1s0Hn5optTeKPOs+X1s9606 rogid:fHw2WStW9AkHtrKs+PZGzLCdGuM9606 intact-crc:B8C71821CF47A8CE|rigid:BtNIzIp7f0+26GViCLFcZM2s1ic false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q4VCS5 uniprotkb:O14910 intact:EBI-2511319|ensembl:ENSP00000361027|uniprotkb:Q504X5|uniprotkb:Q9UPT1|uniprotkb:Q9HD27 intact:EBI-2513988|ensembl:ENSP00000447488|uniprotkb:Q147W1|uniprotkb:Q6LES3|uniprotkb:A4FTY3|uniprotkb:Q7LDS4 psi-mi:amot_human(display_long)|uniprotkb:AMOT(gene name)|psi-mi:AMOT(display_short)|uniprotkb:KIAA1071(gene name synonym) psi-mi:lin7a_human(display_long)|uniprotkb:LIN7A(gene name)|psi-mi:LIN7A(display_short)|uniprotkb:MALS1(gene name synonym)|uniprotkb:VELI1(gene name synonym)|uniprotkb:Mammalian lin-seven protein 1(gene name synonym)|uniprotkb:Vertebrate lin-7 homolog 1(gene name synonym)|uniprotkb:Tax interaction protein 33(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513986|imex:IM-12079-88 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000126016(gene)|ensembl:ENST00000371959(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0001725"(stress fiber)|go:"GO:0001726"(ruffle)|go:"GO:0003365"(establishment of cell polarity involved in ameboidal cell migration)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006935"(chemotaxis)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030054"(cell junction)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035329"(hippo signaling)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0040019"(positive regulation of embryonic development)|go:"GO:0042074"(cell migration involved in gastrulation)|go:"GO:0043116"(negative regulation of vascular permeability)|go:"GO:0043532"(angiostatin binding)|go:"GO:0043534"(blood vessel endothelial cell migration)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0051496"(positive regulation of stress fiber assembly)|interpro:IPR009114(Angiomotin)|interpro:IPR024646|mint:Q4VCS5|rcsb pdb:6JJX|reactome:R-HSA-2028269|refseq:XP_011529177.1|refseq:NP_001106962.1|refseq:NP_573572.1|refseq:XP_005262144.1|refseq:XP_005262147.1|refseq:XP_016884778.1|dip:DIP-53711N ensembl:ENSG00000111052(gene)|ensembl:ENST00000552864(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006887"(exocytosis)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0015031"(protein transport)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0045199"(maintenance of epithelial cell apical/basal polarity)|go:"GO:0045202"(synapse)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0048839"(inner ear development)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097016"(L27 domain binding)|go:"GO:0097025"(MPP7-DLG1-LIN7 complex)|go:"GO:0098793"(presynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:1903361"(protein localization to basolateral plasma membrane)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR004172(L27)|interpro:IPR014775(L27, C-terminal)|interpro:IPR017365(Lin-7 homologue)|interpro:IPR036034|interpro:IPR036892|mint:O14910|reactome:R-HSA-212676|reactome:R-HSA-6794361|reactome:R-HSA-9609736|refseq:NP_004655.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2017/12/08 rogid:5O9K+GgX1s0Hn5optTeKPOs+X1s9606 rogid:Gjtcmp87UCSpimmQfPflbYgJlQc9606 intact-crc:B8C71821CF47A8CE|rigid:BtNIzIp7f0+26GViCLFcZM2s1ic false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q4VCS5 uniprotkb:Q96FJ2 intact:EBI-2511319|ensembl:ENSP00000361027|uniprotkb:Q504X5|uniprotkb:Q9UPT1|uniprotkb:Q9HD27 intact:EBI-742371|uniprotkb:B2R5B4|ensembl:ENSP00000477310 psi-mi:amot_human(display_long)|uniprotkb:AMOT(gene name)|psi-mi:AMOT(display_short)|uniprotkb:KIAA1071(gene name synonym) psi-mi:dyl2_human(display_long)|uniprotkb:DYNLL2(gene name)|psi-mi:DYNLL2(display_short)|uniprotkb:Dynein light chain LC8-type 2(gene name synonym)|uniprotkb:DLC2(gene name synonym)|uniprotkb:8 kDa dynein light chain b(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513986|imex:IM-12079-88 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000126016(gene)|ensembl:ENST00000371959(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0001725"(stress fiber)|go:"GO:0001726"(ruffle)|go:"GO:0003365"(establishment of cell polarity involved in ameboidal cell migration)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006935"(chemotaxis)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030054"(cell junction)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035329"(hippo signaling)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0040019"(positive regulation of embryonic development)|go:"GO:0042074"(cell migration involved in gastrulation)|go:"GO:0043116"(negative regulation of vascular permeability)|go:"GO:0043532"(angiostatin binding)|go:"GO:0043534"(blood vessel endothelial cell migration)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0051496"(positive regulation of stress fiber assembly)|interpro:IPR009114(Angiomotin)|interpro:IPR024646|mint:Q4VCS5|rcsb pdb:6JJX|reactome:R-HSA-2028269|refseq:XP_011529177.1|refseq:NP_001106962.1|refseq:NP_573572.1|refseq:XP_005262144.1|refseq:XP_005262147.1|refseq:XP_016884778.1|dip:DIP-53711N go:"GO:0005813"(centrosome)|refseq:NP_542408.1|ensembl:ENSG00000264364(gene)|ensembl:ENST00000579991(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0007017"(microtubule-based process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0030286"(dynein complex)|go:"GO:0031475"(myosin V complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045505"(dynein intermediate chain binding)|go:"GO:0051959"(dynein light intermediate chain binding)|go:"GO:0060271"(cilium assembly)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097542"(ciliary tip)|go:"GO:0097731"(9+0 non-motile cilium)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:2000582"(obsolete positive regulation of microtubule motor activity, plus-end-directed)|interpro:IPR001372(Dynein light chain, type 1 and 2)|interpro:IPR019763|interpro:IPR037177|mint:Q96FJ2|rcsb pdb:2XQQ|rcsb pdb:3P8M|rcsb pdb:4D07|reactome:R-HSA-139910|reactome:R-HSA-141444|reactome:R-HSA-1632852|reactome:R-HSA-2132295|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-3371497|reactome:R-HSA-5620924|reactome:R-HSA-5663220|reactome:R-HSA-6807878|reactome:R-HSA-6811436|reactome:R-HSA-68877|reactome:R-HSA-9609690|reactome:R-HSA-9646399|reactome:R-HSA-9648025 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2017/12/08 rogid:5O9K+GgX1s0Hn5optTeKPOs+X1s9606 rogid:4RFpJF40RBja5mOvt/aCv3miiDU9606 intact-crc:B8C71821CF47A8CE|rigid:BtNIzIp7f0+26GViCLFcZM2s1ic false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q4VCS5 uniprotkb:Q8IY63 intact:EBI-2511319|ensembl:ENSP00000361027|uniprotkb:Q504X5|uniprotkb:Q9UPT1|uniprotkb:Q9HD27 intact:EBI-1057112|uniprotkb:Q63HK7|uniprotkb:Q8NDN0|uniprotkb:Q8WXD1|uniprotkb:Q96CM5|intact:EBI-2514012|uniprotkb:Q8TEN8|intact:EBI-28986258|ensembl:ENSP00000387739 psi-mi:amot_human(display_long)|uniprotkb:AMOT(gene name)|psi-mi:AMOT(display_short)|uniprotkb:KIAA1071(gene name synonym) psi-mi:amol1_human(display_long)|uniprotkb:AMOTL1(gene name)|psi-mi:AMOTL1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513986|imex:IM-12079-88 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000126016(gene)|ensembl:ENST00000371959(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0001725"(stress fiber)|go:"GO:0001726"(ruffle)|go:"GO:0003365"(establishment of cell polarity involved in ameboidal cell migration)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006935"(chemotaxis)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030054"(cell junction)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035329"(hippo signaling)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0040019"(positive regulation of embryonic development)|go:"GO:0042074"(cell migration involved in gastrulation)|go:"GO:0043116"(negative regulation of vascular permeability)|go:"GO:0043532"(angiostatin binding)|go:"GO:0043534"(blood vessel endothelial cell migration)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0051496"(positive regulation of stress fiber assembly)|interpro:IPR009114(Angiomotin)|interpro:IPR024646|mint:Q4VCS5|rcsb pdb:6JJX|reactome:R-HSA-2028269|refseq:XP_011529177.1|refseq:NP_001106962.1|refseq:NP_573572.1|refseq:XP_005262144.1|refseq:XP_005262147.1|refseq:XP_016884778.1|dip:DIP-53711N refseq:NP_001287936.1|refseq:NP_570899.1|ensembl:ENST00000317829|ensembl:ENSP00000320968|ensembl:ENSP00000387739|ensembl:ENSG00000166025(gene)|ensembl:ENST00000433060(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0003365"(establishment of cell polarity involved in ameboidal cell migration)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0035329"(hippo signaling)|go:"GO:0042802"(identical protein binding)|interpro:IPR009114(Angiomotin)|interpro:IPR024646|mint:Q8IY63|reactome:R-HSA-2028269|dip:DIP-50682N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2017/12/08 rogid:5O9K+GgX1s0Hn5optTeKPOs+X1s9606 rogid:yveF+96pkmFC0XntrVNmwhrVzK09606 intact-crc:B8C71821CF47A8CE|rigid:BtNIzIp7f0+26GViCLFcZM2s1ic false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q4VCS5 uniprotkb:O95817 intact:EBI-2511319|ensembl:ENSP00000361027|uniprotkb:Q504X5|uniprotkb:Q9UPT1|uniprotkb:Q9HD27 intact:EBI-747185|uniprotkb:Q3B763|uniprotkb:Q9NT20|uniprotkb:Q9P120|uniprotkb:A8K5L8|ensembl:ENSP00000358081 psi-mi:amot_human(display_long)|uniprotkb:AMOT(gene name)|psi-mi:AMOT(display_short)|uniprotkb:KIAA1071(gene name synonym) psi-mi:bag3_human(display_long)|uniprotkb:Bcl-2-associated athanogene 3(gene name synonym)|uniprotkb:Bcl-2-binding protein Bis(gene name synonym)|uniprotkb:Docking protein CAIR-1(gene name synonym)|uniprotkb:BAG3(gene name)|psi-mi:BAG3(display_short)|uniprotkb:BIS(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513986|imex:IM-12079-88 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000126016(gene)|ensembl:ENST00000371959(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0001725"(stress fiber)|go:"GO:0001726"(ruffle)|go:"GO:0003365"(establishment of cell polarity involved in ameboidal cell migration)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006935"(chemotaxis)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030054"(cell junction)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035329"(hippo signaling)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0040019"(positive regulation of embryonic development)|go:"GO:0042074"(cell migration involved in gastrulation)|go:"GO:0043116"(negative regulation of vascular permeability)|go:"GO:0043532"(angiostatin binding)|go:"GO:0043534"(blood vessel endothelial cell migration)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0051496"(positive regulation of stress fiber assembly)|interpro:IPR009114(Angiomotin)|interpro:IPR024646|mint:Q4VCS5|rcsb pdb:6JJX|reactome:R-HSA-2028269|refseq:XP_011529177.1|refseq:NP_001106962.1|refseq:NP_573572.1|refseq:XP_005262144.1|refseq:XP_005262147.1|refseq:XP_016884778.1|dip:DIP-53711N refseq:NP_004272.2|ensembl:ENSG00000151929(gene)|ensembl:ENST00000369085(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0001725"(stress fiber)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0007420"(brain development)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0010664"(negative regulation of striated muscle cell apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0016235"(aggresome)|go:"GO:0021510"(spinal cord development)|go:"GO:0030018"(Z disc)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0043005"(neuron projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045505"(dynein intermediate chain binding)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0061684"(chaperone-mediated autophagy)|go:"GO:0070842"(aggresome assembly)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0097201"(negative regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0098840"(protein transport along microtubule)|go:"GO:0140597"(protein carrier chaperone)|go:"GO:1903215"(negative regulation of protein targeting to mitochondrion)|go:"GO:1905337"(positive regulation of aggrephagy)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR003103(Apoptosis regulator Bcl-2 protein, BAG)|interpro:IPR036020|interpro:IPR036533|interpro:IPR039773|mint:O95817|reactome:R-HSA-3371453|go:"GO:0101031"(chaperone complex)|dip:DIP-41273N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2017/12/08 rogid:5O9K+GgX1s0Hn5optTeKPOs+X1s9606 rogid:Ld26VRSMJghXG/U98A76RijSDBc9606 intact-crc:B8C71821CF47A8CE|rigid:BtNIzIp7f0+26GViCLFcZM2s1ic false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q4VCS5 uniprotkb:P85037 intact:EBI-2511319|ensembl:ENSP00000361027|uniprotkb:Q504X5|uniprotkb:Q9UPT1|uniprotkb:Q9HD27 intact:EBI-2509974|ensembl:ENSP00000328720 psi-mi:amot_human(display_long)|uniprotkb:AMOT(gene name)|psi-mi:AMOT(display_short)|uniprotkb:KIAA1071(gene name synonym) psi-mi:foxk1_human(display_long)|uniprotkb:FOXK1(gene name)|psi-mi:FOXK1(display_short)|uniprotkb:MNF(gene name synonym)|uniprotkb:Myocyte nuclear factor(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513986|imex:IM-12079-88 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000126016(gene)|ensembl:ENST00000371959(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0001725"(stress fiber)|go:"GO:0001726"(ruffle)|go:"GO:0003365"(establishment of cell polarity involved in ameboidal cell migration)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006935"(chemotaxis)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030054"(cell junction)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035329"(hippo signaling)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0040019"(positive regulation of embryonic development)|go:"GO:0042074"(cell migration involved in gastrulation)|go:"GO:0043116"(negative regulation of vascular permeability)|go:"GO:0043532"(angiostatin binding)|go:"GO:0043534"(blood vessel endothelial cell migration)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0051496"(positive regulation of stress fiber assembly)|interpro:IPR009114(Angiomotin)|interpro:IPR024646|mint:Q4VCS5|rcsb pdb:6JJX|reactome:R-HSA-2028269|refseq:XP_011529177.1|refseq:NP_001106962.1|refseq:NP_573572.1|refseq:XP_005262144.1|refseq:XP_005262147.1|refseq:XP_016884778.1|dip:DIP-53711N ensembl:ENSG00000164916(gene)|ensembl:ENST00000328914(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007517"(muscle organ development)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010906"(regulation of glucose metabolic process)|go:"GO:0030154"(cell differentiation)|go:"GO:0042594"(response to starvation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0061621"(canonical glycolysis)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000253(Forkhead-associated)|interpro:IPR001766(Fork head transcription factor)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR018122|interpro:IPR030456|interpro:IPR036388|interpro:IPR036390|reactome:R-HSA-5689603|refseq:XP_011513493.1|refseq:NP_001032242.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2017/12/08 rogid:5O9K+GgX1s0Hn5optTeKPOs+X1s9606 rogid:ngoE3oNlIDGkTf1ZMYG4OQ6lvE09606 intact-crc:B8C71821CF47A8CE|rigid:BtNIzIp7f0+26GViCLFcZM2s1ic false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q4VCS5 uniprotkb:Q4VCS5 intact:EBI-2511319|ensembl:ENSP00000361027|uniprotkb:Q504X5|uniprotkb:Q9UPT1|uniprotkb:Q9HD27 intact:EBI-2511319|ensembl:ENSP00000361027|uniprotkb:Q504X5|uniprotkb:Q9UPT1|uniprotkb:Q9HD27 psi-mi:amot_human(display_long)|uniprotkb:AMOT(gene name)|psi-mi:AMOT(display_short)|uniprotkb:KIAA1071(gene name synonym) psi-mi:amot_human(display_long)|uniprotkb:AMOT(gene name)|psi-mi:AMOT(display_short)|uniprotkb:KIAA1071(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513986|imex:IM-12079-88 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000126016(gene)|ensembl:ENST00000371959(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0001725"(stress fiber)|go:"GO:0001726"(ruffle)|go:"GO:0003365"(establishment of cell polarity involved in ameboidal cell migration)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006935"(chemotaxis)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030054"(cell junction)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035329"(hippo signaling)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0040019"(positive regulation of embryonic development)|go:"GO:0042074"(cell migration involved in gastrulation)|go:"GO:0043116"(negative regulation of vascular permeability)|go:"GO:0043532"(angiostatin binding)|go:"GO:0043534"(blood vessel endothelial cell migration)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0051496"(positive regulation of stress fiber assembly)|interpro:IPR009114(Angiomotin)|interpro:IPR024646|mint:Q4VCS5|rcsb pdb:6JJX|reactome:R-HSA-2028269|refseq:XP_011529177.1|refseq:NP_001106962.1|refseq:NP_573572.1|refseq:XP_005262144.1|refseq:XP_005262147.1|refseq:XP_016884778.1|dip:DIP-53711N ensembl:ENSG00000126016(gene)|ensembl:ENST00000371959(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0001725"(stress fiber)|go:"GO:0001726"(ruffle)|go:"GO:0003365"(establishment of cell polarity involved in ameboidal cell migration)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006935"(chemotaxis)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030054"(cell junction)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035329"(hippo signaling)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0040019"(positive regulation of embryonic development)|go:"GO:0042074"(cell migration involved in gastrulation)|go:"GO:0043116"(negative regulation of vascular permeability)|go:"GO:0043532"(angiostatin binding)|go:"GO:0043534"(blood vessel endothelial cell migration)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0051496"(positive regulation of stress fiber assembly)|interpro:IPR009114(Angiomotin)|interpro:IPR024646|mint:Q4VCS5|rcsb pdb:6JJX|reactome:R-HSA-2028269|refseq:XP_011529177.1|refseq:NP_001106962.1|refseq:NP_573572.1|refseq:XP_005262144.1|refseq:XP_005262147.1|refseq:XP_016884778.1|dip:DIP-53711N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2017/12/08 rogid:5O9K+GgX1s0Hn5optTeKPOs+X1s9606 rogid:5O9K+GgX1s0Hn5optTeKPOs+X1s9606 intact-crc:B8C71821CF47A8CE|rigid:BtNIzIp7f0+26GViCLFcZM2s1ic false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q4VCS5 uniprotkb:Q86WA8 intact:EBI-2511319|ensembl:ENSP00000361027|uniprotkb:Q504X5|uniprotkb:Q9UPT1|uniprotkb:Q9HD27 intact:EBI-2513996|ensembl:ENSP00000285737|uniprotkb:Q96K43|uniprotkb:Q8N3B9|uniprotkb:Q0D2H6|uniprotkb:Q8NCE9|uniprotkb:B7ZKL7 psi-mi:amot_human(display_long)|uniprotkb:AMOT(gene name)|psi-mi:AMOT(display_short)|uniprotkb:KIAA1071(gene name synonym) psi-mi:lonp2_human(display_long)|uniprotkb:LONP2(gene name)|psi-mi:LONP2(display_short)|uniprotkb:LONP(gene name synonym)|uniprotkb:Lon protease-like protein 2(gene name synonym)|uniprotkb:Peroxisomal Lon protease(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513986|imex:IM-12079-88 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000126016(gene)|ensembl:ENST00000371959(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0001725"(stress fiber)|go:"GO:0001726"(ruffle)|go:"GO:0003365"(establishment of cell polarity involved in ameboidal cell migration)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006935"(chemotaxis)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030054"(cell junction)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035329"(hippo signaling)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0040019"(positive regulation of embryonic development)|go:"GO:0042074"(cell migration involved in gastrulation)|go:"GO:0043116"(negative regulation of vascular permeability)|go:"GO:0043532"(angiostatin binding)|go:"GO:0043534"(blood vessel endothelial cell migration)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0051496"(positive regulation of stress fiber assembly)|interpro:IPR009114(Angiomotin)|interpro:IPR024646|mint:Q4VCS5|rcsb pdb:6JJX|reactome:R-HSA-2028269|refseq:XP_011529177.1|refseq:NP_001106962.1|refseq:NP_573572.1|refseq:XP_005262144.1|refseq:XP_005262147.1|refseq:XP_016884778.1|dip:DIP-53711N ensembl:ENSG00000102910(gene)|ensembl:ENST00000285737(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0004176"(ATP-dependent peptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005777"(peroxisome)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006515"(protein quality control for misfolded or incompletely synthesized proteins)|go:"GO:0006625"(protein targeting to peroxisome)|go:"GO:0007031"(peroxisome organization)|go:"GO:0008233"(peptidase activity)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0016020"(membrane)|go:"GO:0016485"(protein processing)|go:"GO:0016558"(protein import into peroxisome matrix)|go:"GO:0019899"(enzyme binding)|go:"GO:0031998"(regulation of fatty acid beta-oxidation)|interpro:IPR003111(Peptidase S16, lon N-terminal)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR004815(Peptidase S16, ATP-dependent protease La)|interpro:IPR008268(Peptidase S16, active site)|interpro:IPR008269(Peptidase S16, lon C-terminal)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR015947(PUA-like)|interpro:IPR020568|interpro:IPR027065|interpro:IPR027417|interpro:IPR027501|reactome:R-HSA-390471|reactome:R-HSA-9033241|refseq:NP_001287877.1|refseq:NP_113678.2 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2017/12/08 rogid:5O9K+GgX1s0Hn5optTeKPOs+X1s9606 rogid:WyZglDz2aZOpnRVtWTrAf62G0pA9606 intact-crc:B8C71821CF47A8CE|rigid:BtNIzIp7f0+26GViCLFcZM2s1ic false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q4VCS5 uniprotkb:Q96RL1 intact:EBI-2511319|ensembl:ENSP00000361027|uniprotkb:Q504X5|uniprotkb:Q9UPT1|uniprotkb:Q9HD27 intact:EBI-725300|intact:EBI-1263554|uniprotkb:Q5XKQ1|uniprotkb:Q7Z3W7|uniprotkb:Q8N5B9|uniprotkb:Q9BZR1|uniprotkb:Q9BZR5|uniprotkb:Q9UHX7|uniprotkb:A8MSA1|uniprotkb:B3KMZ1|uniprotkb:B4E3N2|ensembl:ENSP00000366434|ensembl:ENSP00000421926 psi-mi:amot_human(display_long)|uniprotkb:AMOT(gene name)|psi-mi:AMOT(display_short)|uniprotkb:KIAA1071(gene name synonym) psi-mi:uimc1_human(display_long)|uniprotkb:Retinoid X receptor-interacting protein 110(gene name synonym)|uniprotkb:Receptor-associated protein 80(gene name synonym)|uniprotkb:Ubiquitin interaction motif-containing protein 1(gene name synonym)|uniprotkb:UIMC1(gene name)|psi-mi:UIMC1(display_short)|uniprotkb:RAP80(gene name synonym)|uniprotkb:RXRIP110(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513986|imex:IM-12079-88 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000126016(gene)|ensembl:ENST00000371959(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0001725"(stress fiber)|go:"GO:0001726"(ruffle)|go:"GO:0003365"(establishment of cell polarity involved in ameboidal cell migration)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006935"(chemotaxis)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030054"(cell junction)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035329"(hippo signaling)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0040019"(positive regulation of embryonic development)|go:"GO:0042074"(cell migration involved in gastrulation)|go:"GO:0043116"(negative regulation of vascular permeability)|go:"GO:0043532"(angiostatin binding)|go:"GO:0043534"(blood vessel endothelial cell migration)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0051496"(positive regulation of stress fiber assembly)|interpro:IPR009114(Angiomotin)|interpro:IPR024646|mint:Q4VCS5|rcsb pdb:6JJX|reactome:R-HSA-2028269|refseq:XP_011529177.1|refseq:NP_001106962.1|refseq:NP_573572.1|refseq:XP_005262144.1|refseq:XP_005262147.1|refseq:XP_016884778.1|dip:DIP-53711N refseq:NP_001186226.1|refseq:NP_001186227.1|refseq:NP_057374.3|refseq:NP_001304890.1|ensembl:ENSG00000087206(gene)|ensembl:ENST00000377227(transcript)|ensembl:ENST00000511320(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006302"(double-strand break repair)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016604"(nuclear body)|go:"GO:0042393"(histone binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0070531"(BRCA1-A complex)|go:"GO:0070537"(histone H2A K63-linked deubiquitination)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR006642(Zinc finger, Rad18-type putative)|interpro:IPR038868|interpro:IPR040714|mint:Q96RL1|rcsb pdb:2MKF|rcsb pdb:2MKG|rcsb pdb:2N9E|rcsb pdb:2RR9|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473|refseq:XP_005265987.1|refseq:XP_005265993.1|refseq:XP_006714934.1|refseq:XP_016865063.1|refseq:XP_016865067.1|refseq:XP_016865068.1|dip:DIP-29936N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2017/12/08 rogid:5O9K+GgX1s0Hn5optTeKPOs+X1s9606 rogid:j5ho+aD4tkX7bXXlROdiprUX1Mc9606 intact-crc:B8C71821CF47A8CE|rigid:BtNIzIp7f0+26GViCLFcZM2s1ic false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q4VCS5 uniprotkb:P63167 intact:EBI-2511319|ensembl:ENSP00000361027|uniprotkb:Q504X5|uniprotkb:Q9UPT1|uniprotkb:Q9HD27 intact:EBI-349105|uniprotkb:Q15701|ensembl:ENSP00000242577|ensembl:ENSP00000376296|ensembl:ENSP00000376297|ensembl:ENSP00000446614|ensembl:ENSP00000447907 psi-mi:amot_human(display_long)|uniprotkb:AMOT(gene name)|psi-mi:AMOT(display_short)|uniprotkb:KIAA1071(gene name synonym) psi-mi:dyl1_human(display_long)|uniprotkb:DYNLL1(gene name)|psi-mi:DYNLL1(display_short)|uniprotkb:DLC1(gene name synonym)|uniprotkb:DNCLC1(gene name synonym)|uniprotkb:HDLC1(gene name synonym)|uniprotkb:Dynein light chain LC8-type 1(gene name synonym)|uniprotkb:8 kDa dynein light chain(gene name synonym)|uniprotkb:Protein inhibitor of neuronal nitric oxide synthase(gene name synonym)|uniprotkb:DNCL1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513986|imex:IM-12079-88 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000126016(gene)|ensembl:ENST00000371959(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0001725"(stress fiber)|go:"GO:0001726"(ruffle)|go:"GO:0003365"(establishment of cell polarity involved in ameboidal cell migration)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006935"(chemotaxis)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030054"(cell junction)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035329"(hippo signaling)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0040019"(positive regulation of embryonic development)|go:"GO:0042074"(cell migration involved in gastrulation)|go:"GO:0043116"(negative regulation of vascular permeability)|go:"GO:0043532"(angiostatin binding)|go:"GO:0043534"(blood vessel endothelial cell migration)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0051496"(positive regulation of stress fiber assembly)|interpro:IPR009114(Angiomotin)|interpro:IPR024646|mint:Q4VCS5|rcsb pdb:6JJX|reactome:R-HSA-2028269|refseq:XP_011529177.1|refseq:NP_001106962.1|refseq:NP_573572.1|refseq:XP_005262144.1|refseq:XP_005262147.1|refseq:XP_016884778.1|dip:DIP-53711N refseq:NP_001032583.1|refseq:NP_001032584.1|refseq:NP_003737.1|go:"GO:0072686"(mitotic spindle)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097542"(ciliary tip)|go:"GO:0101003"(ficolin-1-rich granule membrane)|go:"GO:1904115"(axon cytoplasm)|go:"GO:2000582"(obsolete positive regulation of microtubule motor activity, plus-end-directed)|interpro:IPR001372(Dynein light chain, type 1 and 2)|interpro:IPR019763|interpro:IPR037177|mint:P63167|rcsb pdb:1CMI|rcsb pdb:3ZKE|rcsb pdb:3ZKF|rcsb pdb:6GZJ|rcsb pdb:6GZL|rcsb pdb:6RLB|rcsb pdb:6SC2|rcsb pdb:7D35|reactome:R-HSA-111446|reactome:R-HSA-141444|reactome:R-HSA-1632852|reactome:R-HSA-2132295|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-2565942|reactome:R-HSA-3371497|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-5620924|reactome:R-HSA-5663220|reactome:R-HSA-6798695|reactome:R-HSA-6807878|reactome:R-HSA-6811436|reactome:R-HSA-68877|reactome:R-HSA-8854518|reactome:R-HSA-9609690|reactome:R-HSA-9646399|reactome:R-HSA-9648025|go:"GO:0000776"(kinetochore)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005813"(centrosome)|go:"GO:0060271"(cilium assembly)|go:"GO:0005829"(cytosol)|go:"GO:0070821"(tertiary granule membrane)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0006915"(apoptotic process)|go:"GO:0007017"(microtubule-based process)|go:"GO:0007286"(spermatid development)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0021762"(substantia nigra development)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030286"(dynein complex)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042326"(negative regulation of phosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045019"(negative regulation of nitric oxide biosynthetic process)|go:"GO:0045505"(dynein intermediate chain binding)|go:"GO:0051959"(dynein light intermediate chain binding)|ensembl:ENSG00000088986(gene)|ensembl:ENST00000242577(transcript)|ensembl:ENST00000392508(transcript)|ensembl:ENST00000392509(transcript)|ensembl:ENST00000548342(transcript)|ensembl:ENST00000549989(transcript)|dip:DIP-33150N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2017/12/08 rogid:5O9K+GgX1s0Hn5optTeKPOs+X1s9606 rogid:Bra4LfaqYPMyo6xX9RD6G7Rdv809606 intact-crc:B8C71821CF47A8CE|rigid:BtNIzIp7f0+26GViCLFcZM2s1ic false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q4VCS5 uniprotkb:P35240 intact:EBI-2511319|ensembl:ENSP00000361027|uniprotkb:Q504X5|uniprotkb:Q9UPT1|uniprotkb:Q9HD27 intact:EBI-1014472|uniprotkb:O95683|uniprotkb:Q8WUJ2|uniprotkb:Q969N0|uniprotkb:Q969Q3|uniprotkb:Q96T30|uniprotkb:Q96T31|uniprotkb:Q96T32|uniprotkb:Q96T33|uniprotkb:Q9BTW3|uniprotkb:Q9UNG9|uniprotkb:Q9UNH3|uniprotkb:Q9UNH4|ensembl:ENSP00000344666 psi-mi:amot_human(display_long)|uniprotkb:AMOT(gene name)|psi-mi:AMOT(display_short)|uniprotkb:KIAA1071(gene name synonym) psi-mi:merl_human(display_long)|uniprotkb:Moesin-ezrin-radixin-like protein(gene name synonym)|uniprotkb:Neurofibromin-2(gene name synonym)|uniprotkb:Schwannomin(gene name synonym)|uniprotkb:Schwannomerlin(gene name synonym)|uniprotkb:NF2(gene name)|psi-mi:NF2(display_short)|uniprotkb:SCH(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513986|imex:IM-12079-88 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000126016(gene)|ensembl:ENST00000371959(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0001725"(stress fiber)|go:"GO:0001726"(ruffle)|go:"GO:0003365"(establishment of cell polarity involved in ameboidal cell migration)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006935"(chemotaxis)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030054"(cell junction)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035329"(hippo signaling)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0040019"(positive regulation of embryonic development)|go:"GO:0042074"(cell migration involved in gastrulation)|go:"GO:0043116"(negative regulation of vascular permeability)|go:"GO:0043532"(angiostatin binding)|go:"GO:0043534"(blood vessel endothelial cell migration)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0051496"(positive regulation of stress fiber assembly)|interpro:IPR009114(Angiomotin)|interpro:IPR024646|mint:Q4VCS5|rcsb pdb:6JJX|reactome:R-HSA-2028269|refseq:XP_011529177.1|refseq:NP_001106962.1|refseq:NP_573572.1|refseq:XP_005262144.1|refseq:XP_005262147.1|refseq:XP_016884778.1|dip:DIP-53711N refseq:NP_000259.1|refseq:NP_057502.2|refseq:NP_861546.1|refseq:NP_861966.1|refseq:NP_861967.1|refseq:NP_861968.1|refseq:NP_861969.1|refseq:NP_861970.1|refseq:NP_861971.1|ensembl:ENSG00000186575(gene)|ensembl:ENST00000338641(transcript)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007398"(ectoderm development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014010"(Schwann cell proliferation)|go:"GO:0014013"(regulation of gliogenesis)|go:"GO:0016020"(membrane)|go:"GO:0021766"(hippocampus development)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031527"(filopodium membrane)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032587"(ruffle membrane)|go:"GO:0035330"(regulation of hippo signaling)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042532"(negative regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0044297"(cell body)|go:"GO:0045177"(apical part of cell)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0046426"(negative regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070306"(lens fiber cell differentiation)|go:"GO:0072091"(regulation of stem cell proliferation)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:2000177"(regulation of neural precursor cell proliferation)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000798(Ezrin/radixin/moesin ERM)|interpro:IPR008954(Moesin)|interpro:IPR011174(Ezrin/radixin/moesin)|interpro:IPR011259(Ezrin/radixin/moesin, C-terminal)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR018979|interpro:IPR018980|interpro:IPR019747|interpro:IPR019748|interpro:IPR019749|interpro:IPR029071|interpro:IPR035963|interpro:IPR041789|mint:P35240|rcsb pdb:1H4R|rcsb pdb:3U8Z|rcsb pdb:4ZRI|rcsb pdb:4ZRJ|rcsb pdb:6CDS|reactome:R-HSA-2029482|reactome:R-HSA-5627123|dip:DIP-35389N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2017/12/08 rogid:5O9K+GgX1s0Hn5optTeKPOs+X1s9606 rogid:YyzGKX6SmAvbiIgejNTvu/64uXc9606 intact-crc:B8C71821CF47A8CE|rigid:BtNIzIp7f0+26GViCLFcZM2s1ic false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q4VCS5 uniprotkb:O75970 intact:EBI-2511319|ensembl:ENSP00000361027|uniprotkb:Q504X5|uniprotkb:Q9UPT1|uniprotkb:Q9HD27 intact:EBI-821405|intact:EBI-2684724|uniprotkb:Q4LE30|uniprotkb:B7ZMI4|uniprotkb:A6NLC2|uniprotkb:O43798|uniprotkb:Q5CZ80|uniprotkb:Q5JTX3|uniprotkb:Q5JTX6|uniprotkb:Q5JTX7|uniprotkb:Q5JUC3|uniprotkb:Q5JUC4|uniprotkb:Q5VZ62|uniprotkb:Q8N790|intact:EBI-10961605|uniprotkb:B2RTS3|ensembl:ENSP00000320006 psi-mi:amot_human(display_long)|uniprotkb:AMOT(gene name)|psi-mi:AMOT(display_short)|uniprotkb:KIAA1071(gene name synonym) psi-mi:mpdz_human(display_long)|uniprotkb:Multi-PDZ domain protein 1(gene name synonym)|uniprotkb:MPDZ(gene name)|psi-mi:MPDZ(display_short)|uniprotkb:MUPP1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513986|imex:IM-12079-88 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000126016(gene)|ensembl:ENST00000371959(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0001725"(stress fiber)|go:"GO:0001726"(ruffle)|go:"GO:0003365"(establishment of cell polarity involved in ameboidal cell migration)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006935"(chemotaxis)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030054"(cell junction)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035329"(hippo signaling)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0040019"(positive regulation of embryonic development)|go:"GO:0042074"(cell migration involved in gastrulation)|go:"GO:0043116"(negative regulation of vascular permeability)|go:"GO:0043532"(angiostatin binding)|go:"GO:0043534"(blood vessel endothelial cell migration)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0051496"(positive regulation of stress fiber assembly)|interpro:IPR009114(Angiomotin)|interpro:IPR024646|mint:Q4VCS5|rcsb pdb:6JJX|reactome:R-HSA-2028269|refseq:XP_011529177.1|refseq:NP_001106962.1|refseq:NP_573572.1|refseq:XP_005262144.1|refseq:XP_005262147.1|refseq:XP_016884778.1|dip:DIP-53711N refseq:XP_006716948.1|refseq:XP_006716949.1|refseq:XP_006716950.1|refseq:XP_006716951.1|refseq:XP_006716952.1|refseq:XP_006716954.1|refseq:NP_003820.2|refseq:NP_001248335.1|refseq:NP_001248336.1|refseq:NP_001317566.1|refseq:XP_016870742.1|ensembl:ENSG00000107186(gene)|ensembl:ENST00000319217(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0030425"(dendrite)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR004172(L27)|interpro:IPR015132(L27-2)|interpro:IPR032078|interpro:IPR036034|interpro:IPR036892|mint:O75970|rcsb pdb:2FCF|rcsb pdb:2FNE|rcsb pdb:2IWN|rcsb pdb:2IWO|rcsb pdb:2IWP|rcsb pdb:2IWQ|rcsb pdb:2O2T|rcsb pdb:2OPG|rcsb pdb:2QG1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2017/12/08 rogid:5O9K+GgX1s0Hn5optTeKPOs+X1s9606 rogid:Q5QzIDHLoL/sWqQI7r/Kb4VLSdY9606 intact-crc:B8C71821CF47A8CE|rigid:BtNIzIp7f0+26GViCLFcZM2s1ic false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q4VCS5 uniprotkb:Q96PU5 intact:EBI-2511319|ensembl:ENSP00000361027|uniprotkb:Q504X5|uniprotkb:Q9UPT1|uniprotkb:Q9HD27 intact:EBI-717962|uniprotkb:O43165|uniprotkb:Q7Z5F1|uniprotkb:Q7Z5F2|uniprotkb:Q7Z5N3|uniprotkb:Q8N5A7|uniprotkb:Q8WUU9|uniprotkb:Q9BW58|uniprotkb:Q9H2W4|uniprotkb:Q9NT88|uniprotkb:Q3LSM7|intact:EBI-28979180|ensembl:ENSP00000383199 psi-mi:amot_human(display_long)|uniprotkb:AMOT(gene name)|psi-mi:AMOT(display_short)|uniprotkb:KIAA1071(gene name synonym) psi-mi:ned4l_human(display_long)|uniprotkb:Nedd4-2(gene name synonym)|uniprotkb:NEDD4.2(gene name synonym)|uniprotkb:NEDD4L(gene name)|psi-mi:NEDD4L(display_short)|uniprotkb:KIAA0439(gene name synonym)|uniprotkb:NEDL3(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase NED4L(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2513986|imex:IM-12079-88 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000126016(gene)|ensembl:ENST00000371959(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0001725"(stress fiber)|go:"GO:0001726"(ruffle)|go:"GO:0003365"(establishment of cell polarity involved in ameboidal cell migration)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006935"(chemotaxis)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030054"(cell junction)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035329"(hippo signaling)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0040019"(positive regulation of embryonic development)|go:"GO:0042074"(cell migration involved in gastrulation)|go:"GO:0043116"(negative regulation of vascular permeability)|go:"GO:0043532"(angiostatin binding)|go:"GO:0043534"(blood vessel endothelial cell migration)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0051496"(positive regulation of stress fiber assembly)|interpro:IPR009114(Angiomotin)|interpro:IPR024646|mint:Q4VCS5|rcsb pdb:6JJX|reactome:R-HSA-2028269|refseq:XP_011529177.1|refseq:NP_001106962.1|refseq:NP_573572.1|refseq:XP_005262144.1|refseq:XP_005262147.1|refseq:XP_016884778.1|dip:DIP-53711N refseq:NP_001138436.1|refseq:NP_001138437.1|refseq:NP_001138438.1|refseq:NP_001138439.1|refseq:NP_001138440.1|refseq:NP_001138441.1|refseq:NP_001138442.1|refseq:NP_056092.2|refseq:NP_001230889.1|ensembl:ENSP00000383199|ensembl:ENSP00000372301|ensembl:ENST00000431212|ensembl:ENSP00000389406|ensembl:ENST00000435432|ensembl:ENSP00000393395|ensembl:ENST00000456173|ensembl:ENSP00000405440|ensembl:ENST00000456986|ensembl:ENSP00000411947|ensembl:ENST00000586263|ensembl:ENSP00000468546|ensembl:ENST00000674517|ensembl:ENSP00000501665|ensembl:ENST00000675502|ensembl:ENSP00000502428|ensembl:ENST00000675801|ensembl:ENSP00000502688|ensembl:ENST00000675865|ensembl:ENSP00000502003|ensembl:ENST00000676226|ensembl:ENSP00000502325|ensembl:ENST00000256830|ensembl:ENSP00000256830|ensembl:ENST00000356462|ensembl:ENSP00000348847|ensembl:ENST00000357895|ensembl:ENSP00000350569|ensembl:ENST00000382850|refseq:XP_016881168.1|refseq:NP_001138443.1|ensembl:ENSG00000049759(gene)|ensembl:ENST00000400345(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0003254"(regulation of membrane depolarization)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005771"(multivesicular body)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006814"(sodium ion transport)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0007588"(excretion)|go:"GO:0010038"(response to metal ion)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0017080"(sodium channel regulator activity)|go:"GO:0019870"(potassium channel inhibitor activity)|go:"GO:0019871"(sodium channel inhibitor activity)|go:"GO:0030104"(water homeostasis)|go:"GO:0030154"(cell differentiation)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0060306"(regulation of membrane repolarization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0086005"(ventricular cardiac muscle cell action potential)|go:"GO:1901016"(regulation of potassium ion transmembrane transporter activity)|go:"GO:1901017"(negative regulation of potassium ion transmembrane transporter activity)|go:"GO:1901380"(negative regulation of potassium ion transmembrane transport)|go:"GO:1902306"(negative regulation of sodium ion transmembrane transport)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:2000009"(negative regulation of protein localization to cell surface)|go:"GO:2000650"(negative regulation of sodium ion transmembrane transporter activity)|go:"GO:2001288"(positive regulation of caveolin-mediated endocytosis)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|rcsb pdb:2LAJ|rcsb pdb:2LB2|rcsb pdb:2LTY|rcsb pdb:2MPT|rcsb pdb:2NSQ|rcsb pdb:2ONI|rcsb pdb:3JVZ|rcsb pdb:3JW0|rcsb pdb:5HPK|reactome:R-HSA-162588|reactome:R-HSA-2173788|reactome:R-HSA-2173795|reactome:R-HSA-2672351|reactome:R-HSA-983168|mint:Q96PU5|dip:DIP-41935N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2017/12/08 rogid:5O9K+GgX1s0Hn5optTeKPOs+X1s9606 rogid:HrKtKY/e1+GYwm5PbBxMO+7XOc09606 intact-crc:B8C71821CF47A8CE|rigid:BtNIzIp7f0+26GViCLFcZM2s1ic false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9NXR7 uniprotkb:Q9UNL2 intact:EBI-949389|ensembl:ENSP00000339371|ensembl:ENSP00000368945|uniprotkb:Q13880|uniprotkb:Q96P06|uniprotkb:A8K4X1|uniprotkb:Q4ZFX8|uniprotkb:Q53SD0|uniprotkb:Q969X9|uniprotkb:D6W562|uniprotkb:D6W563 intact:EBI-1043938|uniprotkb:Q549M4|ensembl:ENSP00000265044|uniprotkb:B2R7D0|uniprotkb:D3DNK5|uniprotkb:B4E2P2 psi-mi:baba2_human(display_long)|uniprotkb:BABAM2(gene name)|psi-mi:BABAM2(display_short)|uniprotkb:BRCA1-A complex subunit BRE(gene name synonym)|uniprotkb:BRCA1/BRCA2-containing complex subunit 45(gene name synonym)|uniprotkb:BRCC45(gene name synonym)|uniprotkb:BRE(gene name synonym)|uniprotkb:Brain and reproductive organ-expressed protein(gene name synonym) psi-mi:ssrg_human(display_long)|uniprotkb:Signal sequence receptor subunit gamma(gene name synonym)|uniprotkb:SSR3(gene name)|psi-mi:SSR3(display_short)|uniprotkb:TRAPG(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514089|imex:IM-12079-38 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000158019(gene)|ensembl:ENST00000342045(transcript)|ensembl:ENST00000379624(transcript)|go:"GO:0000152"(nuclear ubiquitin ligase complex)|go:"GO:0000268"(peroxisome targeting sequence binding)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0007165"(signal transduction)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0051301"(cell division)|go:"GO:0070531"(BRCA1-A complex)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0070552"(BRISC complex)|interpro:IPR010358(Brain and reproductive organ-expressed)|rcsb pdb:6H3C|rcsb pdb:6R8F|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473|go:"GO:0006302"(double-strand break repair)|refseq:NP_004890.2|refseq:NP_954661.1|refseq:NP_954662.1|refseq:NP_954663.1|refseq:NP_954664.1|refseq:NP_001248769.1|refseq:NP_001316041.1|refseq:NP_001316042.1 refseq:NP_009038.1|ensembl:ENSG00000114850(gene)|ensembl:ENST00000265044(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006614"(SRP-dependent cotranslational protein targeting to membrane)|go:"GO:0016021"(integral component of membrane)|interpro:IPR009779(Translocon-associated, gamma subunit)|mint:Q9UNL2|reactome:R-HSA-1799339|refseq:NP_001295126.1|refseq:NP_001295133.1|refseq:NP_001295134.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:ULbrw0O7e5M0Hzho3d05OlUnEGM9606 rogid:Fb918T41oaTpc+kzNIygp1h1tlo9606 intact-crc:EAAF25AFF824BF89|rigid:w2WzJddNAqI+Krx+eztK1TS+GIA false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9NXR7 uniprotkb:P42704 intact:EBI-949389|ensembl:ENSP00000339371|ensembl:ENSP00000368945|uniprotkb:Q13880|uniprotkb:Q96P06|uniprotkb:A8K4X1|uniprotkb:Q4ZFX8|uniprotkb:Q53SD0|uniprotkb:Q969X9|uniprotkb:D6W562|uniprotkb:D6W563 intact:EBI-1050853|uniprotkb:A0PJE3|uniprotkb:A8K1V1|uniprotkb:Q53PC0|uniprotkb:Q53QN7|uniprotkb:Q96D84|uniprotkb:Q6ZUD8|uniprotkb:Q7Z7A6|ensembl:ENSP00000260665 psi-mi:baba2_human(display_long)|uniprotkb:BABAM2(gene name)|psi-mi:BABAM2(display_short)|uniprotkb:BRCA1-A complex subunit BRE(gene name synonym)|uniprotkb:BRCA1/BRCA2-containing complex subunit 45(gene name synonym)|uniprotkb:BRCC45(gene name synonym)|uniprotkb:BRE(gene name synonym)|uniprotkb:Brain and reproductive organ-expressed protein(gene name synonym) psi-mi:lpprc_human(display_long)|uniprotkb:130 kDa leucine-rich protein(gene name synonym)|uniprotkb:GP130(gene name synonym)|uniprotkb:LRPPRC(gene name)|psi-mi:LRPPRC(display_short)|uniprotkb:LRP130(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514089|imex:IM-12079-38 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000158019(gene)|ensembl:ENST00000342045(transcript)|ensembl:ENST00000379624(transcript)|go:"GO:0000152"(nuclear ubiquitin ligase complex)|go:"GO:0000268"(peroxisome targeting sequence binding)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0007165"(signal transduction)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0051301"(cell division)|go:"GO:0070531"(BRCA1-A complex)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0070552"(BRISC complex)|interpro:IPR010358(Brain and reproductive organ-expressed)|rcsb pdb:6H3C|rcsb pdb:6R8F|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473|go:"GO:0006302"(double-strand break repair)|refseq:NP_004890.2|refseq:NP_954661.1|refseq:NP_954662.1|refseq:NP_954663.1|refseq:NP_954664.1|refseq:NP_001248769.1|refseq:NP_001316041.1|refseq:NP_001316042.1 refseq:NP_573566.2|ensembl:ENSG00000138095(gene)|ensembl:ENST00000260665(transcript)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0000961"(negative regulation of mitochondrial RNA catabolic process)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005640"(nuclear outer membrane)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005874"(microtubule)|go:"GO:0008017"(microtubule binding)|go:"GO:0016020"(membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0047497"(mitochondrion transport along microtubule)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0051028"(mRNA transport)|go:"GO:0070129"(regulation of mitochondrial translation)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR002885(Pentatricopeptide repeat)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR033443|interpro:IPR033490|mint:P42704|reactome:R-HSA-5628897|reactome:R-HSA-611105|reactome:R-HSA-9707564|dip:DIP-27543N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:ULbrw0O7e5M0Hzho3d05OlUnEGM9606 rogid:U0ERiW4agkBDQ7iWXWgRQxhozkg9606 intact-crc:EAAF25AFF824BF89|rigid:w2WzJddNAqI+Krx+eztK1TS+GIA false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9NXR7 uniprotkb:Q96AY4 intact:EBI-949389|ensembl:ENSP00000339371|ensembl:ENSP00000368945|uniprotkb:Q13880|uniprotkb:Q96P06|uniprotkb:A8K4X1|uniprotkb:Q4ZFX8|uniprotkb:Q53SD0|uniprotkb:Q969X9|uniprotkb:D6W562|uniprotkb:D6W563 intact:EBI-310646|uniprotkb:O95928|uniprotkb:O95929|uniprotkb:Q9NTE4|uniprotkb:Q9UG31|uniprotkb:Q9UGG5|uniprotkb:Q9UPV8|uniprotkb:Q9Y3S5|uniprotkb:Q5W189|ensembl:ENSP00000381003|uniprotkb:K7ZRV2 psi-mi:baba2_human(display_long)|uniprotkb:BABAM2(gene name)|psi-mi:BABAM2(display_short)|uniprotkb:BRCA1-A complex subunit BRE(gene name synonym)|uniprotkb:BRCA1/BRCA2-containing complex subunit 45(gene name synonym)|uniprotkb:BRCC45(gene name synonym)|uniprotkb:BRE(gene name synonym)|uniprotkb:Brain and reproductive organ-expressed protein(gene name synonym) psi-mi:ttc28_human(display_long)|uniprotkb:TTC28(gene name)|psi-mi:TTC28(display_short)|uniprotkb:KIAA1043(gene name synonym)|uniprotkb:TPR repeat-containing big gene cloned at Keio(gene name synonym)|uniprotkb:TPRBK(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514089|imex:IM-12079-38 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000158019(gene)|ensembl:ENST00000342045(transcript)|ensembl:ENST00000379624(transcript)|go:"GO:0000152"(nuclear ubiquitin ligase complex)|go:"GO:0000268"(peroxisome targeting sequence binding)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0007165"(signal transduction)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0051301"(cell division)|go:"GO:0070531"(BRCA1-A complex)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0070552"(BRISC complex)|interpro:IPR010358(Brain and reproductive organ-expressed)|rcsb pdb:6H3C|rcsb pdb:6R8F|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473|go:"GO:0006302"(double-strand break repair)|refseq:NP_004890.2|refseq:NP_954661.1|refseq:NP_954662.1|refseq:NP_954663.1|refseq:NP_954664.1|refseq:NP_001248769.1|refseq:NP_001316041.1|refseq:NP_001316042.1 refseq:NP_001138890.1|ensembl:ENSG00000100154(gene)|ensembl:ENST00000397906(transcript)|go:"GO:0000922"(spindle pole)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0007049"(cell cycle)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0019900"(kinase binding)|go:"GO:0030496"(midbody)|go:"GO:0051301"(cell division)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR024983|ensembl:ENSP00000381003 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:ULbrw0O7e5M0Hzho3d05OlUnEGM9606 rogid:40Pgac+IuZJIi1b1br1E23v0glI9606 intact-crc:EAAF25AFF824BF89|rigid:w2WzJddNAqI+Krx+eztK1TS+GIA false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9NXR7 uniprotkb:Q9NWV8 intact:EBI-949389|ensembl:ENSP00000339371|ensembl:ENSP00000368945|uniprotkb:Q13880|uniprotkb:Q96P06|uniprotkb:A8K4X1|uniprotkb:Q4ZFX8|uniprotkb:Q53SD0|uniprotkb:Q969X9|uniprotkb:D6W562|uniprotkb:D6W563 intact:EBI-745725|uniprotkb:Q6FIA0|uniprotkb:Q9P018|uniprotkb:A8MQT0|uniprotkb:B4DRY9|uniprotkb:B4DVR1|ensembl:ENSP00000352408|ensembl:ENSP00000470920|ensembl:ENSP00000471605 psi-mi:baba2_human(display_long)|uniprotkb:BABAM2(gene name)|psi-mi:BABAM2(display_short)|uniprotkb:BRCA1-A complex subunit BRE(gene name synonym)|uniprotkb:BRCA1/BRCA2-containing complex subunit 45(gene name synonym)|uniprotkb:BRCC45(gene name synonym)|uniprotkb:BRE(gene name synonym)|uniprotkb:Brain and reproductive organ-expressed protein(gene name synonym) psi-mi:baba1_human(display_long)|uniprotkb:BABAM1(gene name)|psi-mi:BABAM1(display_short)|uniprotkb:HSPC142(orf name)|uniprotkb:C19orf62(gene name synonym)|uniprotkb:NBA1(gene name synonym)|uniprotkb:Mediator of RAP80 interactions and targeting subunit of 40 kDa(gene name synonym)|uniprotkb:New component of the BRCA1-A complex(gene name synonym)|uniprotkb:MERIT40(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514089|imex:IM-12079-38 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000158019(gene)|ensembl:ENST00000342045(transcript)|ensembl:ENST00000379624(transcript)|go:"GO:0000152"(nuclear ubiquitin ligase complex)|go:"GO:0000268"(peroxisome targeting sequence binding)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0007165"(signal transduction)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0051301"(cell division)|go:"GO:0070531"(BRCA1-A complex)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0070552"(BRISC complex)|interpro:IPR010358(Brain and reproductive organ-expressed)|rcsb pdb:6H3C|rcsb pdb:6R8F|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473|go:"GO:0006302"(double-strand break repair)|refseq:NP_004890.2|refseq:NP_954661.1|refseq:NP_954662.1|refseq:NP_954663.1|refseq:NP_954664.1|refseq:NP_001248769.1|refseq:NP_001316041.1|refseq:NP_001316042.1 refseq:NP_001028721.1|refseq:NP_054892.2|ensembl:ENSG00000105393(gene)|ensembl:ENST00000359435(transcript)|ensembl:ENST00000598188(transcript)|ensembl:ENST00000601043(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006325"(chromatin organization)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016604"(nuclear body)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0051301"(cell division)|go:"GO:0070531"(BRCA1-A complex)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0070552"(BRISC complex)|interpro:IPR026126|interpro:IPR036465|mint:Q9NWV8|rcsb pdb:6H3C|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473|refseq:NP_001275685.1|refseq:NP_001275686.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:ULbrw0O7e5M0Hzho3d05OlUnEGM9606 rogid:o71OvjzuL/7w4247ap7fm6i3pXU9606 intact-crc:EAAF25AFF824BF89|rigid:w2WzJddNAqI+Krx+eztK1TS+GIA false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9NXR7 uniprotkb:Q96RL1 intact:EBI-949389|ensembl:ENSP00000339371|ensembl:ENSP00000368945|uniprotkb:Q13880|uniprotkb:Q96P06|uniprotkb:A8K4X1|uniprotkb:Q4ZFX8|uniprotkb:Q53SD0|uniprotkb:Q969X9|uniprotkb:D6W562|uniprotkb:D6W563 intact:EBI-725300|intact:EBI-1263554|uniprotkb:Q5XKQ1|uniprotkb:Q7Z3W7|uniprotkb:Q8N5B9|uniprotkb:Q9BZR1|uniprotkb:Q9BZR5|uniprotkb:Q9UHX7|uniprotkb:A8MSA1|uniprotkb:B3KMZ1|uniprotkb:B4E3N2|ensembl:ENSP00000366434|ensembl:ENSP00000421926 psi-mi:baba2_human(display_long)|uniprotkb:BABAM2(gene name)|psi-mi:BABAM2(display_short)|uniprotkb:BRCA1-A complex subunit BRE(gene name synonym)|uniprotkb:BRCA1/BRCA2-containing complex subunit 45(gene name synonym)|uniprotkb:BRCC45(gene name synonym)|uniprotkb:BRE(gene name synonym)|uniprotkb:Brain and reproductive organ-expressed protein(gene name synonym) psi-mi:uimc1_human(display_long)|uniprotkb:Retinoid X receptor-interacting protein 110(gene name synonym)|uniprotkb:Receptor-associated protein 80(gene name synonym)|uniprotkb:Ubiquitin interaction motif-containing protein 1(gene name synonym)|uniprotkb:UIMC1(gene name)|psi-mi:UIMC1(display_short)|uniprotkb:RAP80(gene name synonym)|uniprotkb:RXRIP110(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514089|imex:IM-12079-38 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000158019(gene)|ensembl:ENST00000342045(transcript)|ensembl:ENST00000379624(transcript)|go:"GO:0000152"(nuclear ubiquitin ligase complex)|go:"GO:0000268"(peroxisome targeting sequence binding)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0007165"(signal transduction)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0051301"(cell division)|go:"GO:0070531"(BRCA1-A complex)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0070552"(BRISC complex)|interpro:IPR010358(Brain and reproductive organ-expressed)|rcsb pdb:6H3C|rcsb pdb:6R8F|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473|go:"GO:0006302"(double-strand break repair)|refseq:NP_004890.2|refseq:NP_954661.1|refseq:NP_954662.1|refseq:NP_954663.1|refseq:NP_954664.1|refseq:NP_001248769.1|refseq:NP_001316041.1|refseq:NP_001316042.1 refseq:NP_001186226.1|refseq:NP_001186227.1|refseq:NP_057374.3|refseq:NP_001304890.1|ensembl:ENSG00000087206(gene)|ensembl:ENST00000377227(transcript)|ensembl:ENST00000511320(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006302"(double-strand break repair)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016604"(nuclear body)|go:"GO:0042393"(histone binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0070531"(BRCA1-A complex)|go:"GO:0070537"(histone H2A K63-linked deubiquitination)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR006642(Zinc finger, Rad18-type putative)|interpro:IPR038868|interpro:IPR040714|mint:Q96RL1|rcsb pdb:2MKF|rcsb pdb:2MKG|rcsb pdb:2N9E|rcsb pdb:2RR9|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473|refseq:XP_005265987.1|refseq:XP_005265993.1|refseq:XP_006714934.1|refseq:XP_016865063.1|refseq:XP_016865067.1|refseq:XP_016865068.1|dip:DIP-29936N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:ULbrw0O7e5M0Hzho3d05OlUnEGM9606 rogid:j5ho+aD4tkX7bXXlROdiprUX1Mc9606 intact-crc:EAAF25AFF824BF89|rigid:w2WzJddNAqI+Krx+eztK1TS+GIA false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9NXR7 uniprotkb:P34897 intact:EBI-949389|ensembl:ENSP00000339371|ensembl:ENSP00000368945|uniprotkb:Q13880|uniprotkb:Q96P06|uniprotkb:A8K4X1|uniprotkb:Q4ZFX8|uniprotkb:Q53SD0|uniprotkb:Q969X9|uniprotkb:D6W562|uniprotkb:D6W563 intact:EBI-352908|ensembl:ENSP00000333667|uniprotkb:O00740|uniprotkb:Q8N1A5|uniprotkb:B7Z9F1|uniprotkb:E7EQ19|uniprotkb:E7EU43 psi-mi:baba2_human(display_long)|uniprotkb:BABAM2(gene name)|psi-mi:BABAM2(display_short)|uniprotkb:BRCA1-A complex subunit BRE(gene name synonym)|uniprotkb:BRCA1/BRCA2-containing complex subunit 45(gene name synonym)|uniprotkb:BRCC45(gene name synonym)|uniprotkb:BRE(gene name synonym)|uniprotkb:Brain and reproductive organ-expressed protein(gene name synonym) psi-mi:glym_human(display_long)|uniprotkb:SHMT2(gene name)|psi-mi:SHMT2(display_short)|uniprotkb:Glycine hydroxymethyltransferase(gene name synonym)|uniprotkb:Serine methylase(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514089|imex:IM-12079-38 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000158019(gene)|ensembl:ENST00000342045(transcript)|ensembl:ENST00000379624(transcript)|go:"GO:0000152"(nuclear ubiquitin ligase complex)|go:"GO:0000268"(peroxisome targeting sequence binding)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0007165"(signal transduction)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0051301"(cell division)|go:"GO:0070531"(BRCA1-A complex)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0070552"(BRISC complex)|interpro:IPR010358(Brain and reproductive organ-expressed)|rcsb pdb:6H3C|rcsb pdb:6R8F|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473|go:"GO:0006302"(double-strand break repair)|refseq:NP_004890.2|refseq:NP_954661.1|refseq:NP_954662.1|refseq:NP_954663.1|refseq:NP_954664.1|refseq:NP_001248769.1|refseq:NP_001316041.1|refseq:NP_001316042.1 ensembl:ENSG00000182199(gene)|ensembl:ENST00000328923(transcript)|go:"GO:0000900"(translation repressor activity, mRNA regulatory element binding)|go:"GO:0002082"(regulation of oxidative phosphorylation)|go:"GO:0003682"(chromatin binding)|go:"GO:0004372"(glycine hydroxymethyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006544"(glycine metabolic process)|go:"GO:0006563"(L-serine metabolic process)|go:"GO:0006564"(L-serine biosynthetic process)|go:"GO:0006565"(L-serine catabolic process)|go:"GO:0006730"(one-carbon metabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008732"(L-allo-threonine aldolase activity)|go:"GO:0009113"(purine nucleobase biosynthetic process)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0019264"(glycine biosynthetic process from serine)|go:"GO:0030170"(pyridoxal phosphate binding)|go:"GO:0034340"(response to type I interferon)|go:"GO:0035999"(tetrahydrofolate interconversion)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046653"(tetrahydrofolate metabolic process)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0050897"(cobalt ion binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070129"(regulation of mitochondrial translation)|go:"GO:0046655"(folic acid metabolic process)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0070552"(BRISC complex)|go:"GO:0070905"(serine binding)|go:"GO:1903715"(regulation of aerobic respiration)|interpro:IPR001085(Glycine hydroxymethyltransferase)|interpro:IPR015421(Pyridoxal phosphate-dependent transferase, major region, subdomain 1)|interpro:IPR015422(Pyridoxal phosphate-dependent transferase, major region, subdomain 2)|interpro:IPR015424(Pyridoxal phosphate-dependent transferase, major region)|interpro:IPR019798|interpro:IPR039429|mint:P34897|rcsb pdb:4PVF|rcsb pdb:5V7I|rcsb pdb:5X3V|rcsb pdb:6DK3|rcsb pdb:6H3C|rcsb pdb:6M5O|rcsb pdb:6QVG|rcsb pdb:6QVL|rcsb pdb:6R8F|reactome:R-HSA-196757|reactome:R-HSA-9013408|refseq:NP_001159829.1|refseq:NP_001159830.1|refseq:NP_001159831.1|refseq:NP_005403.2|refseq:NP_001159828.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:ULbrw0O7e5M0Hzho3d05OlUnEGM9606 rogid:Ce7izVDbUDULaGUe2fZWlikUZFk9606 intact-crc:EAAF25AFF824BF89|rigid:w2WzJddNAqI+Krx+eztK1TS+GIA false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9NXR7 uniprotkb:Q6UWZ7 intact:EBI-949389|ensembl:ENSP00000339371|ensembl:ENSP00000368945|uniprotkb:Q13880|uniprotkb:Q96P06|uniprotkb:A8K4X1|uniprotkb:Q4ZFX8|uniprotkb:Q53SD0|uniprotkb:Q969X9|uniprotkb:D6W562|uniprotkb:D6W563 intact:EBI-1263451|uniprotkb:Q9H8I1|uniprotkb:Q9H9N4|uniprotkb:A5JJ07|ensembl:ENSP00000369857 psi-mi:baba2_human(display_long)|uniprotkb:BABAM2(gene name)|psi-mi:BABAM2(display_short)|uniprotkb:BRCA1-A complex subunit BRE(gene name synonym)|uniprotkb:BRCA1/BRCA2-containing complex subunit 45(gene name synonym)|uniprotkb:BRCC45(gene name synonym)|uniprotkb:BRE(gene name synonym)|uniprotkb:Brain and reproductive organ-expressed protein(gene name synonym) psi-mi:abrx1_human(display_long)|uniprotkb:ABRAXAS1(gene name)|psi-mi:ABRAXAS1(display_short)|uniprotkb:ABRA1(gene name synonym)|uniprotkb:CCDC98(gene name synonym)|uniprotkb:Coiled-coil domain-containing protein 98(gene name synonym)|uniprotkb:FAM175A(gene name synonym)|uniprotkb:Protein FAM175A(gene name synonym)|uniprotkb:UNQ496/PRO1013(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514089|imex:IM-12079-38 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000158019(gene)|ensembl:ENST00000342045(transcript)|ensembl:ENST00000379624(transcript)|go:"GO:0000152"(nuclear ubiquitin ligase complex)|go:"GO:0000268"(peroxisome targeting sequence binding)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0007165"(signal transduction)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0051301"(cell division)|go:"GO:0070531"(BRCA1-A complex)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0070552"(BRISC complex)|interpro:IPR010358(Brain and reproductive organ-expressed)|rcsb pdb:6H3C|rcsb pdb:6R8F|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473|go:"GO:0006302"(double-strand break repair)|refseq:NP_004890.2|refseq:NP_954661.1|refseq:NP_954662.1|refseq:NP_954663.1|refseq:NP_954664.1|refseq:NP_001248769.1|refseq:NP_001316041.1|refseq:NP_001316042.1 dip:DIP-29615N|refseq:NP_620775.2|refseq:NP_001332891.1|ensembl:ENSG00000163322(gene)|ensembl:ENST00000321945(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006325"(chromatin organization)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0008017"(microtubule binding)|go:"GO:0008608"(attachment of spindle microtubules to kinetochore)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016604"(nuclear body)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0070531"(BRCA1-A complex)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0090307"(mitotic spindle assembly)|interpro:IPR023238|interpro:IPR023239|interpro:IPR037518|rcsb pdb:4JLU|rcsb pdb:4U4A|rcsb pdb:4Y18|rcsb pdb:4Y2G|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473 psi-mi:"MI:0469"(intact) - caution:This sequence has been withdrawn from Uniprot. figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:ULbrw0O7e5M0Hzho3d05OlUnEGM9606 rogid:ZD7wQnqzfRv9owR8/zdgrMP5W6c9606 intact-crc:EAAF25AFF824BF89|rigid:w2WzJddNAqI+Krx+eztK1TS+GIA false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9NXR7 uniprotkb:Q9UJS0 intact:EBI-949389|ensembl:ENSP00000339371|ensembl:ENSP00000368945|uniprotkb:Q13880|uniprotkb:Q96P06|uniprotkb:A8K4X1|uniprotkb:Q4ZFX8|uniprotkb:Q53SD0|uniprotkb:Q969X9|uniprotkb:D6W562|uniprotkb:D6W563 intact:EBI-1222503|uniprotkb:O14566|uniprotkb:O14575|uniprotkb:Q9NZW1|uniprotkb:Q9UNI7|uniprotkb:Q546F9|ensembl:ENSP00000265631 psi-mi:baba2_human(display_long)|uniprotkb:BABAM2(gene name)|psi-mi:BABAM2(display_short)|uniprotkb:BRCA1-A complex subunit BRE(gene name synonym)|uniprotkb:BRCA1/BRCA2-containing complex subunit 45(gene name synonym)|uniprotkb:BRCC45(gene name synonym)|uniprotkb:BRE(gene name synonym)|uniprotkb:Brain and reproductive organ-expressed protein(gene name synonym) psi-mi:cmc2_human(display_long)|uniprotkb:SLC25A13(gene name)|psi-mi:SLC25A13(display_short)|uniprotkb:ARALAR2(gene name synonym)|uniprotkb:Mitochondrial aspartate glutamate carrier 2(gene name synonym)|uniprotkb:Solute carrier family 25 member 13(gene name synonym)|uniprotkb:Citrin(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514089|imex:IM-12079-38 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000158019(gene)|ensembl:ENST00000342045(transcript)|ensembl:ENST00000379624(transcript)|go:"GO:0000152"(nuclear ubiquitin ligase complex)|go:"GO:0000268"(peroxisome targeting sequence binding)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0007165"(signal transduction)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0051301"(cell division)|go:"GO:0070531"(BRCA1-A complex)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0070552"(BRISC complex)|interpro:IPR010358(Brain and reproductive organ-expressed)|rcsb pdb:6H3C|rcsb pdb:6R8F|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473|go:"GO:0006302"(double-strand break repair)|refseq:NP_004890.2|refseq:NP_954661.1|refseq:NP_954662.1|refseq:NP_954663.1|refseq:NP_954664.1|refseq:NP_001248769.1|refseq:NP_001316041.1|refseq:NP_001316042.1 refseq:NP_055066.1|refseq:NP_001153682.1|go:"GO:0005313"(L-glutamate transmembrane transporter activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0006839"(mitochondrial transport)|go:"GO:0009066"(aspartate family amino acid metabolic process)|go:"GO:0015172"(acidic amino acid transmembrane transporter activity)|go:"GO:0015183"(L-aspartate transmembrane transporter activity)|go:"GO:0015810"(aspartate transmembrane transport)|go:"GO:0015813"(L-glutamate transmembrane transport)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043490"(malate-aspartate shuttle)|go:"GO:0045333"(cellular respiration)|go:"GO:0051592"(response to calcium ion)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR002067(Mitochondrial carrier protein)|interpro:IPR011992(EF-Hand type)|interpro:IPR018108|interpro:IPR023395|interpro:IPR029658|mint:Q9UJS0|rcsb pdb:4P5W|reactome:R-HSA-1268020|reactome:R-HSA-70263|reactome:R-HSA-8963693|ensembl:ENSG00000004864(gene)|ensembl:ENST00000265631(transcript) psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:ULbrw0O7e5M0Hzho3d05OlUnEGM9606 rogid:YtrKzkRujsJ/hzl2bJaLgJAAswI9606 intact-crc:EAAF25AFF824BF89|rigid:w2WzJddNAqI+Krx+eztK1TS+GIA false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9NXR7 uniprotkb:Q13616 intact:EBI-949389|ensembl:ENSP00000339371|ensembl:ENSP00000368945|uniprotkb:Q13880|uniprotkb:Q96P06|uniprotkb:A8K4X1|uniprotkb:Q4ZFX8|uniprotkb:Q53SD0|uniprotkb:Q969X9|uniprotkb:D6W562|uniprotkb:D6W563 intact:EBI-359390|uniprotkb:O60719|uniprotkb:Q08AL6|uniprotkb:Q8IYW1|uniprotkb:D3DWG3|ensembl:ENSP00000326804|ensembl:ENSP00000387160|ensembl:ENSP00000473318|ensembl:ENSP00000499255|ensembl:ENSP00000499277|ensembl:ENSP00000499398 psi-mi:baba2_human(display_long)|uniprotkb:BABAM2(gene name)|psi-mi:BABAM2(display_short)|uniprotkb:BRCA1-A complex subunit BRE(gene name synonym)|uniprotkb:BRCA1/BRCA2-containing complex subunit 45(gene name synonym)|uniprotkb:BRCC45(gene name synonym)|uniprotkb:BRE(gene name synonym)|uniprotkb:Brain and reproductive organ-expressed protein(gene name synonym) psi-mi:cul1_human(display_long)|uniprotkb:CUL1(gene name)|psi-mi:CUL1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514089|imex:IM-12079-38 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000158019(gene)|ensembl:ENST00000342045(transcript)|ensembl:ENST00000379624(transcript)|go:"GO:0000152"(nuclear ubiquitin ligase complex)|go:"GO:0000268"(peroxisome targeting sequence binding)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0007165"(signal transduction)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0051301"(cell division)|go:"GO:0070531"(BRCA1-A complex)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0070552"(BRISC complex)|interpro:IPR010358(Brain and reproductive organ-expressed)|rcsb pdb:6H3C|rcsb pdb:6R8F|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473|go:"GO:0006302"(double-strand break repair)|refseq:NP_004890.2|refseq:NP_954661.1|refseq:NP_954662.1|refseq:NP_954663.1|refseq:NP_954664.1|refseq:NP_001248769.1|refseq:NP_001316041.1|refseq:NP_001316042.1 refseq:NP_003583.2|rcsb pdb:6WCQ|rcsb pdb:7B5L|rcsb pdb:7B5M|rcsb pdb:7B5N|rcsb pdb:7B5R|rcsb pdb:7B5S|reactome:R-HSA-1169091|reactome:R-HSA-1170546|reactome:R-HSA-174113|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-2122947|reactome:R-HSA-2565942|reactome:R-HSA-2644606|reactome:R-HSA-2644607|reactome:R-HSA-2871837|reactome:R-HSA-2894862|reactome:R-HSA-400253|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5676590|reactome:R-HSA-5684264|reactome:R-HSA-68949|reactome:R-HSA-69231|reactome:R-HSA-8854050|reactome:R-HSA-8939902|reactome:R-HSA-8951664|reactome:R-HSA-9020702|reactome:R-HSA-917937|reactome:R-HSA-9604323|reactome:R-HSA-9708530|reactome:R-HSA-983168|refseq:XP_011514931.1|refseq:XP_011514932.1|refseq:XP_011514933.1|refseq:XP_011514934.1|ensembl:ENSG00000055130(gene)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|ensembl:ENST00000325222(transcript)|ensembl:ENST00000409469(transcript)|ensembl:ENST00000602748(transcript)|ensembl:ENST00000662716(transcript)|ensembl:ENST00000663044(transcript)|ensembl:ENST00000665936(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:1990452"(Parkin-FBXW7-Cul1 ubiquitin ligase complex)|interpro:IPR001373(Cullin, N-terminal region)|interpro:IPR016157(Cullin, conserved site)|interpro:IPR016158(Cullin homology)|interpro:IPR016159(Cullin repeat-like)|interpro:IPR019559|interpro:IPR036317|interpro:IPR036388|interpro:IPR036390|mint:Q13616|rcsb pdb:1LDJ|rcsb pdb:1LDK|rcsb pdb:1U6G|rcsb pdb:3RTR|rcsb pdb:3TDU|rcsb pdb:3TDZ|rcsb pdb:4F52|rcsb pdb:4P5O|rcsb pdb:5V89|rcsb pdb:6TTU|refseq:XP_005250117.1|dip:DIP-17013N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:ULbrw0O7e5M0Hzho3d05OlUnEGM9606 rogid:OAZP+ifWW3eEnQKb937ww9s1fMQ9606 intact-crc:EAAF25AFF824BF89|rigid:w2WzJddNAqI+Krx+eztK1TS+GIA false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9NXR7 uniprotkb:Q15018 intact:EBI-949389|ensembl:ENSP00000339371|ensembl:ENSP00000368945|uniprotkb:Q13880|uniprotkb:Q96P06|uniprotkb:A8K4X1|uniprotkb:Q4ZFX8|uniprotkb:Q53SD0|uniprotkb:Q969X9|uniprotkb:D6W562|uniprotkb:D6W563 intact:EBI-1056583|uniprotkb:Q96H11|uniprotkb:B4DKR2|intact:EBI-28981592|ensembl:ENSP00000298492 psi-mi:baba2_human(display_long)|uniprotkb:BABAM2(gene name)|psi-mi:BABAM2(display_short)|uniprotkb:BRCA1-A complex subunit BRE(gene name synonym)|uniprotkb:BRCA1/BRCA2-containing complex subunit 45(gene name synonym)|uniprotkb:BRCC45(gene name synonym)|uniprotkb:BRE(gene name synonym)|uniprotkb:Brain and reproductive organ-expressed protein(gene name synonym) psi-mi:abrx2_human(display_long)|uniprotkb:ABRAXAS2(gene name)|psi-mi:ABRAXAS2(display_short)|uniprotkb:ABRO1(gene name synonym)|uniprotkb:Abraxas brother protein 1(gene name synonym)|uniprotkb:FAM175B(gene name synonym)|uniprotkb:KIAA0157(gene name synonym)|uniprotkb:Protein FAM175B(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514089|imex:IM-12079-38 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000158019(gene)|ensembl:ENST00000342045(transcript)|ensembl:ENST00000379624(transcript)|go:"GO:0000152"(nuclear ubiquitin ligase complex)|go:"GO:0000268"(peroxisome targeting sequence binding)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0007165"(signal transduction)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0051301"(cell division)|go:"GO:0070531"(BRCA1-A complex)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0070552"(BRISC complex)|interpro:IPR010358(Brain and reproductive organ-expressed)|rcsb pdb:6H3C|rcsb pdb:6R8F|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473|go:"GO:0006302"(double-strand break repair)|refseq:NP_004890.2|refseq:NP_954661.1|refseq:NP_954662.1|refseq:NP_954663.1|refseq:NP_954664.1|refseq:NP_001248769.1|refseq:NP_001316041.1|refseq:NP_001316042.1 ensembl:ENSP00000298492|refseq:NP_115558.3|ensembl:ENSG00000165660(gene)|ensembl:ENST00000298492(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000922"(spindle pole)|go:"GO:0002931"(response to ischemia)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0007059"(chromosome segregation)|go:"GO:0008017"(microtubule binding)|go:"GO:0008608"(attachment of spindle microtubules to kinetochore)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0051301"(cell division)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0070552"(BRISC complex)|go:"GO:0090307"(mitotic spindle assembly)|interpro:IPR023238|interpro:IPR023240|interpro:IPR037518|mint:Q15018|rcsb pdb:6H3C|rcsb pdb:6R8F|reactome:R-HSA-5689901 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:ULbrw0O7e5M0Hzho3d05OlUnEGM9606 rogid:fYZdQpH09qcBBUV1IKV2wsRk4m89606 intact-crc:EAAF25AFF824BF89|rigid:w2WzJddNAqI+Krx+eztK1TS+GIA false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9NXR7 uniprotkb:Q6IAN0 intact:EBI-949389|ensembl:ENSP00000339371|ensembl:ENSP00000368945|uniprotkb:Q13880|uniprotkb:Q96P06|uniprotkb:A8K4X1|uniprotkb:Q4ZFX8|uniprotkb:Q53SD0|uniprotkb:Q969X9|uniprotkb:D6W562|uniprotkb:D6W563 intact:EBI-725639|uniprotkb:B5MEF4|uniprotkb:Q6UX59|uniprotkb:Q9BTF9|uniprotkb:Q9UFM6|uniprotkb:Q9Y3A1|ensembl:ENSP00000378887 psi-mi:baba2_human(display_long)|uniprotkb:BABAM2(gene name)|psi-mi:BABAM2(display_short)|uniprotkb:BRCA1-A complex subunit BRE(gene name synonym)|uniprotkb:BRCA1/BRCA2-containing complex subunit 45(gene name synonym)|uniprotkb:BRCC45(gene name synonym)|uniprotkb:BRE(gene name synonym)|uniprotkb:Brain and reproductive organ-expressed protein(gene name synonym) psi-mi:drs7b_human(display_long)|uniprotkb:DHRS7B(gene name)|psi-mi:DHRS7B(display_short)|uniprotkb:SDR32C1(gene name synonym)|uniprotkb:Short-chain dehydrogenase/reductase family 32C member 1(gene name synonym)|uniprotkb:CGI-93(orf name)|uniprotkb:UNQ212/PRO238(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514089|imex:IM-12079-38 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000158019(gene)|ensembl:ENST00000342045(transcript)|ensembl:ENST00000379624(transcript)|go:"GO:0000152"(nuclear ubiquitin ligase complex)|go:"GO:0000268"(peroxisome targeting sequence binding)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0007165"(signal transduction)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0051301"(cell division)|go:"GO:0070531"(BRCA1-A complex)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0070552"(BRISC complex)|interpro:IPR010358(Brain and reproductive organ-expressed)|rcsb pdb:6H3C|rcsb pdb:6R8F|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473|go:"GO:0006302"(double-strand break repair)|refseq:NP_004890.2|refseq:NP_954661.1|refseq:NP_954662.1|refseq:NP_954663.1|refseq:NP_954664.1|refseq:NP_001248769.1|refseq:NP_001316041.1|refseq:NP_001316042.1 refseq:NP_056325.2|ensembl:ENSG00000109016(gene)|ensembl:ENST00000395511(transcript)|go:"GO:0000140"(acylglycerone-phosphate reductase activity)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0008611"(ether lipid biosynthetic process)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|interpro:IPR002347(Glucose/ribitol dehydrogenase)|interpro:IPR020904|interpro:IPR036291|reactome:R-HSA-75896|refseq:NP_001317088.1|refseq:XP_016879915.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:ULbrw0O7e5M0Hzho3d05OlUnEGM9606 rogid:qGu2N6bspgbSJE+AIL0Xeh6b0J49606 intact-crc:EAAF25AFF824BF89|rigid:w2WzJddNAqI+Krx+eztK1TS+GIA false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9NXR7 uniprotkb:Q9NYU1 intact:EBI-949389|ensembl:ENSP00000339371|ensembl:ENSP00000368945|uniprotkb:Q13880|uniprotkb:Q96P06|uniprotkb:A8K4X1|uniprotkb:Q4ZFX8|uniprotkb:Q53SD0|uniprotkb:Q969X9|uniprotkb:D6W562|uniprotkb:D6W563 intact:EBI-1054215|uniprotkb:Q5JQR8|uniprotkb:Q9UFC4|uniprotkb:Q08AD0|uniprotkb:A6NKL4|uniprotkb:Q8N5K0|ensembl:ENSP00000365938 psi-mi:baba2_human(display_long)|uniprotkb:BABAM2(gene name)|psi-mi:BABAM2(display_short)|uniprotkb:BRCA1-A complex subunit BRE(gene name synonym)|uniprotkb:BRCA1/BRCA2-containing complex subunit 45(gene name synonym)|uniprotkb:BRCC45(gene name synonym)|uniprotkb:BRE(gene name synonym)|uniprotkb:Brain and reproductive organ-expressed protein(gene name synonym) psi-mi:uggg2_human(display_long)|uniprotkb:UDP-glucose ceramide glucosyltransferase-like 1(gene name synonym)|uniprotkb:"UDP--Glc:glycoprotein glucosyltransferase 2"(gene name synonym)|uniprotkb:UGGT2(gene name)|psi-mi:UGGT2(display_short)|uniprotkb:UGT2(gene name synonym)|uniprotkb:UGCGL2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514089|imex:IM-12079-38 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000158019(gene)|ensembl:ENST00000342045(transcript)|ensembl:ENST00000379624(transcript)|go:"GO:0000152"(nuclear ubiquitin ligase complex)|go:"GO:0000268"(peroxisome targeting sequence binding)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0007165"(signal transduction)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0051301"(cell division)|go:"GO:0070531"(BRCA1-A complex)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0070552"(BRISC complex)|interpro:IPR010358(Brain and reproductive organ-expressed)|rcsb pdb:6H3C|rcsb pdb:6R8F|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473|go:"GO:0006302"(double-strand break repair)|refseq:NP_004890.2|refseq:NP_954661.1|refseq:NP_954662.1|refseq:NP_954663.1|refseq:NP_954664.1|refseq:NP_001248769.1|refseq:NP_001316041.1|refseq:NP_001316042.1 refseq:NP_064506.3|ensembl:ENSG00000102595(gene)|ensembl:ENST00000376747(transcript)|go:"GO:0003980"("UDP-glucose:glycoprotein glucosyltransferase activity")|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0018279"(protein N-linked glycosylation via asparagine)|go:"GO:0032991"(protein-containing complex)|go:"GO:0044322"(endoplasmic reticulum quality control compartment)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071712"(ER-associated misfolded protein catabolic process)|go:"GO:1904380"(endoplasmic reticulum mannose trimming)|interpro:IPR009448("UDP-glucose:Glycoprotein Glucosyltransferase")|interpro:IPR029044|interpro:IPR040497|interpro:IPR040525|interpro:IPR040692|interpro:IPR040693|interpro:IPR040694|reactome:R-HSA-901032 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:ULbrw0O7e5M0Hzho3d05OlUnEGM9606 rogid:jEO6Ao5a4/iJg3Y1DeBydzHDYWM9606 intact-crc:EAAF25AFF824BF89|rigid:w2WzJddNAqI+Krx+eztK1TS+GIA false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9NXR7 uniprotkb:Q2TAZ0 intact:EBI-949389|ensembl:ENSP00000339371|ensembl:ENSP00000368945|uniprotkb:Q13880|uniprotkb:Q96P06|uniprotkb:A8K4X1|uniprotkb:Q4ZFX8|uniprotkb:Q53SD0|uniprotkb:Q969X9|uniprotkb:D6W562|uniprotkb:D6W563 intact:EBI-2514077|intact:EBI-28978291|uniprotkb:Q8TAI8|uniprotkb:O43154|uniprotkb:Q14DM2|uniprotkb:Q7Z6K8|uniprotkb:Q6ZTV2|uniprotkb:Q96HH7|uniprotkb:Q8IVY5|ensembl:ENSP00000366475 psi-mi:baba2_human(display_long)|uniprotkb:BABAM2(gene name)|psi-mi:BABAM2(display_short)|uniprotkb:BRCA1-A complex subunit BRE(gene name synonym)|uniprotkb:BRCA1/BRCA2-containing complex subunit 45(gene name synonym)|uniprotkb:BRCC45(gene name synonym)|uniprotkb:BRE(gene name synonym)|uniprotkb:Brain and reproductive organ-expressed protein(gene name synonym) psi-mi:atg2a_human(display_long)|uniprotkb:ATG2A(gene name)|psi-mi:ATG2A(display_short)|uniprotkb:KIAA0404(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514089|imex:IM-12079-38 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000158019(gene)|ensembl:ENST00000342045(transcript)|ensembl:ENST00000379624(transcript)|go:"GO:0000152"(nuclear ubiquitin ligase complex)|go:"GO:0000268"(peroxisome targeting sequence binding)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0007165"(signal transduction)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0051301"(cell division)|go:"GO:0070531"(BRCA1-A complex)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0070552"(BRISC complex)|interpro:IPR010358(Brain and reproductive organ-expressed)|rcsb pdb:6H3C|rcsb pdb:6R8F|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473|go:"GO:0006302"(double-strand break repair)|refseq:NP_004890.2|refseq:NP_954661.1|refseq:NP_954662.1|refseq:NP_954663.1|refseq:NP_954664.1|refseq:NP_001248769.1|refseq:NP_001316041.1|refseq:NP_001316042.1 refseq:XP_011543165.1|ensembl:ENSP00000366475|ensembl:ENST00000421419|ensembl:ENSP00000410522|refseq:NP_055919.2|ensembl:ENSG00000110046(gene)|ensembl:ENST00000377264(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005811"(lipid droplet)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0032266"(phosphatidylinositol-3-phosphate binding)|go:"GO:0034045"(phagophore assembly site membrane)|go:"GO:0034727"(piecemeal microautophagy of the nucleus)|go:"GO:0044805"(late nucleophagy)|interpro:IPR015412(ATG2, C-terminal)|interpro:IPR026849|interpro:IPR026854|rcsb pdb:6KLR|go:"GO:0061709"(reticulophagy) psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:ULbrw0O7e5M0Hzho3d05OlUnEGM9606 rogid:RC80jQqKw4ekVFudqz/IunWCEMA9606 intact-crc:EAAF25AFF824BF89|rigid:w2WzJddNAqI+Krx+eztK1TS+GIA false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9NXR7 uniprotkb:P46736 intact:EBI-949389|ensembl:ENSP00000339371|ensembl:ENSP00000368945|uniprotkb:Q13880|uniprotkb:Q96P06|uniprotkb:A8K4X1|uniprotkb:Q4ZFX8|uniprotkb:Q53SD0|uniprotkb:Q969X9|uniprotkb:D6W562|uniprotkb:D6W563 intact:EBI-750352|uniprotkb:Q16107|uniprotkb:Q9BTZ6|uniprotkb:A6QRF8|uniprotkb:A6QRF9|uniprotkb:A8MUX5|uniprotkb:A8MWH0|uniprotkb:A9Z1Y0|uniprotkb:A9Z1Y5|uniprotkb:B1B062|uniprotkb:B4DQN7|uniprotkb:Q53YX5|ensembl:ENSP00000358474 psi-mi:baba2_human(display_long)|uniprotkb:BABAM2(gene name)|psi-mi:BABAM2(display_short)|uniprotkb:BRCA1-A complex subunit BRE(gene name synonym)|uniprotkb:BRCA1/BRCA2-containing complex subunit 45(gene name synonym)|uniprotkb:BRCC45(gene name synonym)|uniprotkb:BRE(gene name synonym)|uniprotkb:Brain and reproductive organ-expressed protein(gene name synonym) psi-mi:brcc3_human(display_long)|uniprotkb:BRCC3(gene name)|psi-mi:BRCC3(display_short)|uniprotkb:C6.1A(gene name synonym)|uniprotkb:CXorf53(gene name synonym)|uniprotkb:BRCC36(gene name synonym)|uniprotkb:BRCA1-A complex subunit BRCC36(gene name synonym)|uniprotkb:BRISC complex subunit BRCC36(gene name synonym)|uniprotkb:BRCA1/BRCA2-containing complex subunit 3(gene name synonym)|uniprotkb:BRCA1/BRCA2-containing complex subunit 36(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514089|imex:IM-12079-38 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000158019(gene)|ensembl:ENST00000342045(transcript)|ensembl:ENST00000379624(transcript)|go:"GO:0000152"(nuclear ubiquitin ligase complex)|go:"GO:0000268"(peroxisome targeting sequence binding)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0007165"(signal transduction)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0051301"(cell division)|go:"GO:0070531"(BRCA1-A complex)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0070552"(BRISC complex)|interpro:IPR010358(Brain and reproductive organ-expressed)|rcsb pdb:6H3C|rcsb pdb:6R8F|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473|go:"GO:0006302"(double-strand break repair)|refseq:NP_004890.2|refseq:NP_954661.1|refseq:NP_954662.1|refseq:NP_954663.1|refseq:NP_954664.1|refseq:NP_001248769.1|refseq:NP_001316041.1|refseq:NP_001316042.1 refseq:NP_001018065.1|refseq:NP_001229569.1|refseq:NP_077308.1|refseq:XP_016885327.1|dip:DIP-48719N|ensembl:ENSG00000185515(gene)|go:"GO:0000152"(nuclear ubiquitin ligase complex)|go:"GO:0000922"(spindle pole)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0010165"(response to X-ray)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0046872"(metal ion binding)|go:"GO:0051301"(cell division)|go:"GO:0061578"(Lys63-specific deubiquitinase activity)|go:"GO:0070122"(isopeptidase activity)|ensembl:ENST00000369462(transcript)|go:"GO:0070531"(BRCA1-A complex)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0070537"(histone H2A K63-linked deubiquitination)|go:"GO:0070552"(BRISC complex)|go:"GO:0000151"(ubiquitin ligase complex)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR033860|interpro:IPR037518|interpro:IPR040749|mint:P46736|rcsb pdb:6H3C|rcsb pdb:6R8F|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473 psi-mi:"MI:0469"(intact) - caution:This sequence has been withdrawn from Uniprot.|crc64:5720358C1A2F7421 figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:ULbrw0O7e5M0Hzho3d05OlUnEGM9606 rogid:4YP0TYSnZOZQ4mFEmr07XIx+AVw9606 intact-crc:EAAF25AFF824BF89|rigid:w2WzJddNAqI+Krx+eztK1TS+GIA false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9NXR7 uniprotkb:Q14318 intact:EBI-949389|ensembl:ENSP00000339371|ensembl:ENSP00000368945|uniprotkb:Q13880|uniprotkb:Q96P06|uniprotkb:A8K4X1|uniprotkb:Q4ZFX8|uniprotkb:Q53SD0|uniprotkb:Q969X9|uniprotkb:D6W562|uniprotkb:D6W563 intact:EBI-724839|uniprotkb:Q53GU3|uniprotkb:Q7Z349|uniprotkb:Q86YK6|ensembl:ENSP00000222308|ensembl:ENSP00000472302|uniprotkb:C8C9T5 psi-mi:baba2_human(display_long)|uniprotkb:BABAM2(gene name)|psi-mi:BABAM2(display_short)|uniprotkb:BRCA1-A complex subunit BRE(gene name synonym)|uniprotkb:BRCA1/BRCA2-containing complex subunit 45(gene name synonym)|uniprotkb:BRCC45(gene name synonym)|uniprotkb:BRE(gene name synonym)|uniprotkb:Brain and reproductive organ-expressed protein(gene name synonym) psi-mi:fkbp8_human(display_long)|uniprotkb:FK506-binding protein 8(gene name synonym)|uniprotkb:38 kDa FK506-binding protein(gene name synonym)|uniprotkb:FKBPR38(gene name synonym)|uniprotkb:FKBP8(gene name)|psi-mi:FKBP8(display_short)|uniprotkb:FKBP38(gene name synonym)|uniprotkb:Rotamase(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514089|imex:IM-12079-38 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000158019(gene)|ensembl:ENST00000342045(transcript)|ensembl:ENST00000379624(transcript)|go:"GO:0000152"(nuclear ubiquitin ligase complex)|go:"GO:0000268"(peroxisome targeting sequence binding)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0007165"(signal transduction)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0051301"(cell division)|go:"GO:0070531"(BRCA1-A complex)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0070552"(BRISC complex)|interpro:IPR010358(Brain and reproductive organ-expressed)|rcsb pdb:6H3C|rcsb pdb:6R8F|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473|go:"GO:0006302"(double-strand break repair)|refseq:NP_004890.2|refseq:NP_954661.1|refseq:NP_954662.1|refseq:NP_954663.1|refseq:NP_954664.1|refseq:NP_001248769.1|refseq:NP_001316041.1|refseq:NP_001316042.1 refseq:NP_036313.3|refseq:NP_001295302.1|go:"GO:0001708"(cell fate specification)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006915"(apoptotic process)|go:"GO:0007224"(smoothened signaling pathway)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0021904"(dorsal/ventral neural tube patterning)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0046872"(metal ion binding)|go:"GO:0097718"(disordered domain specific binding)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013105(Tetratricopeptide TPR2)|interpro:IPR019734|mint:Q14318|ensembl:ENSG00000105701(gene)|rcsb pdb:2AWG|rcsb pdb:2D9F|rcsb pdb:2F2D|rcsb pdb:2MF9|rcsb pdb:3EY6|rcsb pdb:5MGX|reactome:R-HSA-5689880|ensembl:ENST00000222308(transcript)|ensembl:ENST00000596558(transcript)|refseq:XP_011526165.1|dip:DIP-42200N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:ULbrw0O7e5M0Hzho3d05OlUnEGM9606 rogid:CpZqwry5szPluwNMwWXshCIMUvY9606 intact-crc:EAAF25AFF824BF89|rigid:w2WzJddNAqI+Krx+eztK1TS+GIA false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9NXR7 uniprotkb:P04844 intact:EBI-949389|ensembl:ENSP00000339371|ensembl:ENSP00000368945|uniprotkb:Q13880|uniprotkb:Q96P06|uniprotkb:A8K4X1|uniprotkb:Q4ZFX8|uniprotkb:Q53SD0|uniprotkb:Q969X9|uniprotkb:D6W562|uniprotkb:D6W563 intact:EBI-719731|uniprotkb:Q5JYR6|uniprotkb:Q9UBE1|uniprotkb:Q6IBA5|uniprotkb:Q96E21|uniprotkb:Q9BUQ3|ensembl:ENSP00000237530 psi-mi:baba2_human(display_long)|uniprotkb:BABAM2(gene name)|psi-mi:BABAM2(display_short)|uniprotkb:BRCA1-A complex subunit BRE(gene name synonym)|uniprotkb:BRCA1/BRCA2-containing complex subunit 45(gene name synonym)|uniprotkb:BRCC45(gene name synonym)|uniprotkb:BRE(gene name synonym)|uniprotkb:Brain and reproductive organ-expressed protein(gene name synonym) psi-mi:rpn2_human(display_long)|uniprotkb:Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 63 kDa subunit(gene name synonym)|uniprotkb:Ribophorin-2(gene name synonym)|uniprotkb:Ribophorin II(gene name synonym)|uniprotkb:RIBIIR(gene name synonym)|uniprotkb:RPN2(gene name)|psi-mi:RPN2(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514089|imex:IM-12079-38 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000158019(gene)|ensembl:ENST00000342045(transcript)|ensembl:ENST00000379624(transcript)|go:"GO:0000152"(nuclear ubiquitin ligase complex)|go:"GO:0000268"(peroxisome targeting sequence binding)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0007165"(signal transduction)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0051301"(cell division)|go:"GO:0070531"(BRCA1-A complex)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0070552"(BRISC complex)|interpro:IPR010358(Brain and reproductive organ-expressed)|rcsb pdb:6H3C|rcsb pdb:6R8F|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473|go:"GO:0006302"(double-strand break repair)|refseq:NP_004890.2|refseq:NP_954661.1|refseq:NP_954662.1|refseq:NP_954663.1|refseq:NP_954664.1|refseq:NP_001248769.1|refseq:NP_001316041.1|refseq:NP_001316042.1 refseq:NP_001129243.1|refseq:NP_002942.2|ensembl:ENSG00000118705(gene)|ensembl:ENST00000237530(transcript)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006487"(protein N-linked glycosylation)|go:"GO:0007568"(aging)|go:"GO:0008250"(oligosaccharyltransferase complex)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0018279"(protein N-linked glycosylation via asparagine)|go:"GO:0042493"|go:"GO:0043022"(ribosome binding)|interpro:IPR008814(Ribophorin II)|mint:P04844|rcsb pdb:6S7O|rcsb pdb:6S7T|reactome:R-HSA-1799339|reactome:R-HSA-446203|reactome:R-HSA-9694548|refseq:NP_001311234.1|refseq:NP_001311235.1|refseq:NP_001311228.1|refseq:NP_001311230.1|refseq:NP_001311231.1|refseq:NP_001311232.1|refseq:NP_001311233.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:ULbrw0O7e5M0Hzho3d05OlUnEGM9606 rogid:7bTuuEb3ykWQvkI/5DKpga48s/w9606 intact-crc:EAAF25AFF824BF89|rigid:w2WzJddNAqI+Krx+eztK1TS+GIA false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9NXR7 uniprotkb:Q96T76 intact:EBI-949389|ensembl:ENSP00000339371|ensembl:ENSP00000368945|uniprotkb:Q13880|uniprotkb:Q96P06|uniprotkb:A8K4X1|uniprotkb:Q4ZFX8|uniprotkb:Q53SD0|uniprotkb:Q969X9|uniprotkb:D6W562|uniprotkb:D6W563 intact:EBI-1044169|uniprotkb:Q9BYS9|uniprotkb:Q17RZ8|uniprotkb:Q5T455|uniprotkb:Q66K82|uniprotkb:Q7L4W8|uniprotkb:Q969Z1|uniprotkb:Q96DF1|uniprotkb:Q96MR1|uniprotkb:Q96RK5|uniprotkb:Q96SK1|uniprotkb:Q9BUE2|ensembl:ENSP00000359818|ensembl:ENSP00000412698|uniprotkb:D3DR55|uniprotkb:B0QZ75|uniprotkb:B3KPE5|uniprotkb:B4DQX2|uniprotkb:B4E2I3|uniprotkb:F8W9Y2 psi-mi:baba2_human(display_long)|uniprotkb:BABAM2(gene name)|psi-mi:BABAM2(display_short)|uniprotkb:BRCA1-A complex subunit BRE(gene name synonym)|uniprotkb:BRCA1/BRCA2-containing complex subunit 45(gene name synonym)|uniprotkb:BRCC45(gene name synonym)|uniprotkb:BRE(gene name synonym)|uniprotkb:Brain and reproductive organ-expressed protein(gene name synonym) psi-mi:mms19_human(display_long)|uniprotkb:MMS19(gene name)|psi-mi:MMS19(display_short)|uniprotkb:MMS19L(gene name synonym)|uniprotkb:MMS19-like protein(gene name synonym)|uniprotkb:MET18 homolog(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514089|imex:IM-12079-38 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000158019(gene)|ensembl:ENST00000342045(transcript)|ensembl:ENST00000379624(transcript)|go:"GO:0000152"(nuclear ubiquitin ligase complex)|go:"GO:0000268"(peroxisome targeting sequence binding)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0007165"(signal transduction)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0051301"(cell division)|go:"GO:0070531"(BRCA1-A complex)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0070552"(BRISC complex)|interpro:IPR010358(Brain and reproductive organ-expressed)|rcsb pdb:6H3C|rcsb pdb:6R8F|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473|go:"GO:0006302"(double-strand break repair)|refseq:NP_004890.2|refseq:NP_954661.1|refseq:NP_954662.1|refseq:NP_954663.1|refseq:NP_954664.1|refseq:NP_001248769.1|refseq:NP_001316041.1|refseq:NP_001316042.1 ensembl:ENSG00000155229(gene)|ensembl:ENST00000370782(transcript)|ensembl:ENST00000438925(transcript)|go:"GO:0000160"(phosphorelay signal transduction system)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0071817"(MMXD complex)|go:"GO:0097361"(CIA complex)|go:"GO:0097428"(protein maturation by iron-sulfur cluster transfer)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR024687|interpro:IPR029240|interpro:IPR039920|mint:Q96T76|reactome:R-HSA-2564830|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0005675"(transcription factor TFIIH holo complex)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0006259"(DNA metabolic process)|go:"GO:0006281"(DNA repair)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007059"(chromosome segregation)|go:"GO:0009725"(response to hormone)|go:"GO:0016020"(membrane)|go:"GO:0016226"(iron-sulfur cluster assembly)|go:"GO:0019899"(enzyme binding)|refseq:NP_071757.4|refseq:NP_001276332.1|refseq:NP_001276333.1|refseq:NP_001276334.1|refseq:NP_001317057.1|refseq:XP_016872013.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:ULbrw0O7e5M0Hzho3d05OlUnEGM9606 rogid:sujw9MQiwau6A0dumVM7gXVMGjE9606 intact-crc:EAAF25AFF824BF89|rigid:w2WzJddNAqI+Krx+eztK1TS+GIA false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9NXR7 uniprotkb:Q96JJ7 intact:EBI-949389|ensembl:ENSP00000339371|ensembl:ENSP00000368945|uniprotkb:Q13880|uniprotkb:Q96P06|uniprotkb:A8K4X1|uniprotkb:Q4ZFX8|uniprotkb:Q53SD0|uniprotkb:Q969X9|uniprotkb:D6W562|uniprotkb:D6W563 intact:EBI-2514069|intact:EBI-28973673|uniprotkb:B3KV75|uniprotkb:Q52LT7|uniprotkb:Q8N5J0|uniprotkb:Q9NWJ9|ensembl:ENSP00000299608 psi-mi:baba2_human(display_long)|uniprotkb:BABAM2(gene name)|psi-mi:BABAM2(display_short)|uniprotkb:BRCA1-A complex subunit BRE(gene name synonym)|uniprotkb:BRCA1/BRCA2-containing complex subunit 45(gene name synonym)|uniprotkb:BRCC45(gene name synonym)|uniprotkb:BRE(gene name synonym)|uniprotkb:Brain and reproductive organ-expressed protein(gene name synonym) psi-mi:tmx3_human(display_long)|uniprotkb:TMX3(gene name)|psi-mi:TMX3(display_short)|uniprotkb:KIAA1830(gene name synonym)|uniprotkb:TXNDC10(gene name synonym)|uniprotkb:Thioredoxin-related transmembrane protein 3(gene name synonym)|uniprotkb:Thioredoxin domain-containing protein 10(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514089|imex:IM-12079-38 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000158019(gene)|ensembl:ENST00000342045(transcript)|ensembl:ENST00000379624(transcript)|go:"GO:0000152"(nuclear ubiquitin ligase complex)|go:"GO:0000268"(peroxisome targeting sequence binding)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0007165"(signal transduction)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0051301"(cell division)|go:"GO:0070531"(BRCA1-A complex)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0070552"(BRISC complex)|interpro:IPR010358(Brain and reproductive organ-expressed)|rcsb pdb:6H3C|rcsb pdb:6R8F|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473|go:"GO:0006302"(double-strand break repair)|refseq:NP_004890.2|refseq:NP_954661.1|refseq:NP_954662.1|refseq:NP_954663.1|refseq:NP_954664.1|refseq:NP_001248769.1|refseq:NP_001316041.1|refseq:NP_001316042.1 ensembl:ENSP00000299608|ensembl:ENST00000562706|ensembl:ENSP00000457262|go:"GO:0003756"(protein disulfide isomerase activity)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0015035"(protein-disulfide reductase activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016972"(thiol oxidase activity)|go:"GO:0018171"(peptidyl-cysteine oxidation)|go:"GO:0031092"(platelet alpha granule membrane)|interpro:IPR013766(Thioredoxin domain)|interpro:IPR017937|interpro:IPR036249|reactome:R-HSA-114608|ensembl:ENST00000299608(transcript)|ensembl:ENSG00000166479(gene)|refseq:NP_061895.3 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:ULbrw0O7e5M0Hzho3d05OlUnEGM9606 rogid:Qber8pA1sCprlKl8Yoc5XtVEd5s9606 intact-crc:EAAF25AFF824BF89|rigid:w2WzJddNAqI+Krx+eztK1TS+GIA false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9NXR7 uniprotkb:P35232 intact:EBI-949389|ensembl:ENSP00000339371|ensembl:ENSP00000368945|uniprotkb:Q13880|uniprotkb:Q96P06|uniprotkb:A8K4X1|uniprotkb:Q4ZFX8|uniprotkb:Q53SD0|uniprotkb:Q969X9|uniprotkb:D6W562|uniprotkb:D6W563 intact:EBI-354213|uniprotkb:Q4VBQ0|uniprotkb:B4DY47|ensembl:ENSP00000300408|ensembl:ENSP00000393320|ensembl:ENSP00000422182|ensembl:ENSP00000425035|ensembl:ENSP00000426433|ensembl:ENSP00000479488|ensembl:ENSP00000484113 psi-mi:baba2_human(display_long)|uniprotkb:BABAM2(gene name)|psi-mi:BABAM2(display_short)|uniprotkb:BRCA1-A complex subunit BRE(gene name synonym)|uniprotkb:BRCA1/BRCA2-containing complex subunit 45(gene name synonym)|uniprotkb:BRCC45(gene name synonym)|uniprotkb:BRE(gene name synonym)|uniprotkb:Brain and reproductive organ-expressed protein(gene name synonym) psi-mi:phb_human(display_long)|uniprotkb:PHB(gene name)|psi-mi:PHB(display_short)|uniprotkb:PHB1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514089|imex:IM-12079-38 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000158019(gene)|ensembl:ENST00000342045(transcript)|ensembl:ENST00000379624(transcript)|go:"GO:0000152"(nuclear ubiquitin ligase complex)|go:"GO:0000268"(peroxisome targeting sequence binding)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0007165"(signal transduction)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0051301"(cell division)|go:"GO:0070531"(BRCA1-A complex)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0070552"(BRISC complex)|interpro:IPR010358(Brain and reproductive organ-expressed)|rcsb pdb:6H3C|rcsb pdb:6R8F|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473|go:"GO:0006302"(double-strand break repair)|refseq:NP_004890.2|refseq:NP_954661.1|refseq:NP_954662.1|refseq:NP_954663.1|refseq:NP_954664.1|refseq:NP_001248769.1|refseq:NP_001316041.1|refseq:NP_001316042.1 refseq:NP_001268426.1|refseq:NP_002625.1|refseq:NP_001268425.1|refseq:NP_001268644.1|refseq:XP_016880252.1|dip:DIP-24248N|ensembl:ENSG00000167085(gene)|ensembl:ENST00000300408(transcript)|ensembl:ENST00000419140(transcript)|ensembl:ENST00000504124(transcript)|ensembl:ENST00000511832(transcript)|ensembl:ENST00000512041(transcript)|ensembl:ENST00000614445(transcript)|ensembl:ENST00000617874(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001850"(complement component C3a binding)|go:"GO:0001851"(complement component C3b binding)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005769"(early endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007165"(signal transduction)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0010944"(negative regulation of transcription by competitive promoter binding)|go:"GO:0016020"(membrane)|go:"GO:0016575"(histone deacetylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0023035"(CD40 signaling pathway)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031871"(proteinase activated receptor binding)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0035632"(mitochondrial prohibitin complex)|go:"GO:0039529"(RIG-I signaling pathway)|go:"GO:0042113"(B cell activation)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045745"(positive regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045917"(positive regulation of complement activation)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050821"(protein stabilization)|go:"GO:0050847"(progesterone receptor signaling pathway)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060766"(negative regulation of androgen receptor signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071354"(cellular response to interleukin-6)|go:"GO:0071897"(DNA biosynthetic process)|go:"GO:0072538"(T-helper 17 type immune response)|go:"GO:0140374"(antiviral innate immune response)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1990051"(activation of protein kinase C activity)|go:"GO:2000323"(negative regulation of glucocorticoid receptor signaling pathway)|interpro:IPR000163(Prohibitin)|interpro:IPR001107(Band 7 protein)|interpro:IPR036013|mint:P35232|rcsb pdb:1LU7|reactome:R-HSA-5673000|reactome:R-HSA-6802946|reactome:R-HSA-6802955|reactome:R-HSA-8949664|reactome:R-HSA-9649948 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:ULbrw0O7e5M0Hzho3d05OlUnEGM9606 rogid:aIJj/q/3JKXuEVRELjKJb2SjCKQ9606 intact-crc:EAAF25AFF824BF89|rigid:w2WzJddNAqI+Krx+eztK1TS+GIA false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y297 uniprotkb:P17612 intact:EBI-307461|uniprotkb:Q9Y213|uniprotkb:B5MD49|uniprotkb:Q5W142|ensembl:ENSP00000359206|uniprotkb:Q5W141 intact:EBI-476586|uniprotkb:Q32P54|uniprotkb:Q9H2Y0|uniprotkb:Q9NRB4|uniprotkb:Q9NRH9|ensembl:ENSP00000309591|ensembl:ENSP00000499940 psi-mi:fbw1a_human(display_long)|uniprotkb:BTRC(gene name)|psi-mi:BTRC(display_short)|uniprotkb:BTRCP(gene name synonym)|uniprotkb:FBW1A(gene name synonym)|uniprotkb:FBXW1A(gene name synonym)|uniprotkb:F-box and WD repeats protein beta-TrCP(gene name synonym)|uniprotkb:E3RSIkappaB(gene name synonym)|uniprotkb:pIkappaBalpha-E3 receptor subunit(gene name synonym)|uniprotkb:Epididymis tissue protein Li 2a(gene name synonym) psi-mi:kapca_human(display_long)|uniprotkb:PRKACA(gene name)|psi-mi:PRKACA(display_short)|uniprotkb:PKACA(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514141|imex:IM-12079-89 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003930.1|refseq:NP_378663.1|ensembl:ENSG00000166167(gene)|ensembl:ENST00000370187(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016874"(ligase activity)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031648"(protein destabilization)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042753"(positive regulation of circadian rhythm)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045309"(protein phosphorylated amino acid binding)|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:1990757"(ubiquitin ligase activator activity)|interpro:IPR001680(WD40 repeat)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|interpro:IPR021977|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|interpro:IPR036047|interpro:IPR036322|mint:Q9Y297|rcsb pdb:1P22|rcsb pdb:2P64|rcsb pdb:6M90|rcsb pdb:6M91|rcsb pdb:6M92|rcsb pdb:6M93|rcsb pdb:6M94|go:"GO:0046983"(protein dimerization activity)|rcsb pdb:6TTU|reactome:R-HSA-1169091|reactome:R-HSA-1170546|go:"GO:0048511"(rhythmic process)|reactome:R-HSA-174113|reactome:R-HSA-180534|reactome:R-HSA-195253|reactome:R-HSA-202424|go:"GO:0051726"(regulation of cell cycle)|reactome:R-HSA-2565942|reactome:R-HSA-2871837|reactome:R-HSA-3769402|reactome:R-HSA-400253|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5676590|reactome:R-HSA-5684264|reactome:R-HSA-8951664|reactome:R-HSA-9020702|reactome:R-HSA-983168|dip:DIP-31607N refseq:NP_002721.1|refseq:NP_997401.1|go:"GO:0005739"(mitochondrion)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005952"(cAMP-dependent protein kinase complex)|go:"GO:0006397"(mRNA processing)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0010737"(protein kinase A signaling)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0016020"(membrane)|go:"GO:0016241"(regulation of macroautophagy)|go:"GO:0016607"(nuclear speck)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|ensembl:ENSG00000072062(gene)|ensembl:ENSG00000288516(gene)|ensembl:ENST00000308677(transcript)|ensembl:ENST00000673550(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001843"(neural tube closure)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0003091"(renal water homeostasis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004679"(AMP-activated protein kinase activity)|go:"GO:0004691"(cAMP-dependent protein kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0034380"(high-density lipoprotein particle assembly)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034704"(calcium channel complex)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0036126"(sperm flagellum)|go:"GO:0043197"(dendritic spine)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0048240"(sperm capacitation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0060314"(regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070613"(regulation of protein processing)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0071872"(cellular response to epinephrine stimulus)|go:"GO:0086064"(cell communication by electrical coupling involved in cardiac conduction)|go:"GO:0097225"(sperm midpiece)|go:"GO:0097546"(ciliary base)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901621"(negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning)|go:"GO:1903779"(regulation of cardiac conduction)|go:"GO:2000810"(regulation of bicellular tight junction assembly)|go:"GO:0046827"(positive regulation of protein export from nucleus)|rcsb pdb:5IZJ|rcsb pdb:5J5X|rcsb pdb:5N23|rcsb pdb:5UZK|rcsb pdb:6BYR|rcsb pdb:6BYS|rcsb pdb:6C0U|rcsb pdb:6FRX|rcsb pdb:6NO7|rcsb pdb:6QJ7|rcsb pdb:6WJF|rcsb pdb:6WJG|reactome:R-HSA-111931|reactome:R-HSA-163358|reactome:R-HSA-163560|reactome:R-HSA-163615|reactome:R-HSA-164378|reactome:R-HSA-180024|reactome:R-HSA-2565942|reactome:R-HSA-380259|rcsb pdb:3MVJ|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:3NX8|interpro:IPR044109|rcsb pdb:3OOG|rcsb pdb:3OVV|rcsb pdb:3OWP|rcsb pdb:3OXT|rcsb pdb:3P0M|mint:P17612|rcsb pdb:3POO|rcsb pdb:3VQH|rcsb pdb:4AE6|rcsb pdb:2GU8|rcsb pdb:4AE9|rcsb pdb:4UJ1|rcsb pdb:4UJ2|rcsb pdb:3AGL|rcsb pdb:3AGM|rcsb pdb:3AMA|rcsb pdb:3AMB|rcsb pdb:4UJ9|rcsb pdb:4UJA|rcsb pdb:4UJB|rcsb pdb:4WB5|rcsb pdb:4WB6|rcsb pdb:4WB7|rcsb pdb:3L9L|rcsb pdb:3L9M|rcsb pdb:3L9N|rcsb pdb:4WB8|rcsb pdb:5BX6|rcsb pdb:5BX7|rcsb pdb:5IZF|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-381676|reactome:R-HSA-392517|reactome:R-HSA-422356|reactome:R-HSA-432040|reactome:R-HSA-4420097|reactome:R-HSA-442720|reactome:R-HSA-512988|reactome:R-HSA-5578775|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5610787|reactome:R-HSA-5620912|reactome:R-HSA-5621575|reactome:R-HSA-5687128|reactome:R-HSA-8853659|reactome:R-HSA-8854518|reactome:R-HSA-380320|reactome:R-HSA-8963896|reactome:R-HSA-9022535|reactome:R-HSA-9022692|reactome:R-HSA-9634600|reactome:R-HSA-9660821|reactome:R-HSA-9664323|reactome:R-HSA-983231|reactome:R-HSA-9010642|refseq:NP_001291278.1|dip:DIP-33878N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/10/11 rogid:9/bXDY6YvJWvP6iMSgOPT9CNGAE9606 rogid:7yhAi67qjSKPIff2dwqjScPXEYM9606 intact-crc:C88D00E873055E9C|rigid:zQdZpbQC3mwJxWVbAmO1KYmI+1k false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y297 uniprotkb:Q9Y266 intact:EBI-307461|uniprotkb:Q9Y213|uniprotkb:B5MD49|uniprotkb:Q5W142|ensembl:ENSP00000359206|uniprotkb:Q5W141 intact:EBI-357298|ensembl:ENSP00000319664|uniprotkb:Q5QP31|uniprotkb:Q5QP35|uniprotkb:Q9H0N2|uniprotkb:Q9Y2B6|intact:EBI-2555945 psi-mi:fbw1a_human(display_long)|uniprotkb:BTRC(gene name)|psi-mi:BTRC(display_short)|uniprotkb:BTRCP(gene name synonym)|uniprotkb:FBW1A(gene name synonym)|uniprotkb:FBXW1A(gene name synonym)|uniprotkb:F-box and WD repeats protein beta-TrCP(gene name synonym)|uniprotkb:E3RSIkappaB(gene name synonym)|uniprotkb:pIkappaBalpha-E3 receptor subunit(gene name synonym)|uniprotkb:Epididymis tissue protein Li 2a(gene name synonym) psi-mi:nudc_human(display_long)|uniprotkb:NUDC(gene name)|psi-mi:NUDC(display_short)|uniprotkb:Nuclear distribution protein C homolog(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514141|imex:IM-12079-89 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003930.1|refseq:NP_378663.1|ensembl:ENSG00000166167(gene)|ensembl:ENST00000370187(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016874"(ligase activity)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031648"(protein destabilization)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042753"(positive regulation of circadian rhythm)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045309"(protein phosphorylated amino acid binding)|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:1990757"(ubiquitin ligase activator activity)|interpro:IPR001680(WD40 repeat)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|interpro:IPR021977|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|interpro:IPR036047|interpro:IPR036322|mint:Q9Y297|rcsb pdb:1P22|rcsb pdb:2P64|rcsb pdb:6M90|rcsb pdb:6M91|rcsb pdb:6M92|rcsb pdb:6M93|rcsb pdb:6M94|go:"GO:0046983"(protein dimerization activity)|rcsb pdb:6TTU|reactome:R-HSA-1169091|reactome:R-HSA-1170546|go:"GO:0048511"(rhythmic process)|reactome:R-HSA-174113|reactome:R-HSA-180534|reactome:R-HSA-195253|reactome:R-HSA-202424|go:"GO:0051726"(regulation of cell cycle)|reactome:R-HSA-2565942|reactome:R-HSA-2871837|reactome:R-HSA-3769402|reactome:R-HSA-400253|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5676590|reactome:R-HSA-5684264|reactome:R-HSA-8951664|reactome:R-HSA-9020702|reactome:R-HSA-983168|dip:DIP-31607N ensembl:ENSG00000090273(gene)|ensembl:ENST00000321265(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0030496"(midbody)|go:"GO:0045296"(cadherin binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051301"(cell division)|go:"GO:0072686"(mitotic spindle)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR032572|interpro:IPR037898|mint:Q9Y266|rcsb pdb:3QOR|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|go:"GO:0007080"(mitotic metaphase plate congression)|reactome:R-HSA-9696270|refseq:NP_006591.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/10/11 rogid:9/bXDY6YvJWvP6iMSgOPT9CNGAE9606 rogid:e1Q+/+VhG73ljCc3+ibG+RZNQUM9606 intact-crc:C88D00E873055E9C|rigid:zQdZpbQC3mwJxWVbAmO1KYmI+1k false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y297 uniprotkb:Q8NF17 intact:EBI-307461|uniprotkb:Q9Y213|uniprotkb:B5MD49|uniprotkb:Q5W142|ensembl:ENSP00000359206|uniprotkb:Q5W141 intact:EBI-2514153 psi-mi:fbw1a_human(display_long)|uniprotkb:BTRC(gene name)|psi-mi:BTRC(display_short)|uniprotkb:BTRCP(gene name synonym)|uniprotkb:FBW1A(gene name synonym)|uniprotkb:FBXW1A(gene name synonym)|uniprotkb:F-box and WD repeats protein beta-TrCP(gene name synonym)|uniprotkb:E3RSIkappaB(gene name synonym)|uniprotkb:pIkappaBalpha-E3 receptor subunit(gene name synonym)|uniprotkb:Epididymis tissue protein Li 2a(gene name synonym) psi-mi:q8nf17_human(display_long)|uniprotkb:FLJ00385(gene name)|psi-mi:FLJ00385(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514141|imex:IM-12079-89 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003930.1|refseq:NP_378663.1|ensembl:ENSG00000166167(gene)|ensembl:ENST00000370187(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016874"(ligase activity)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031648"(protein destabilization)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042753"(positive regulation of circadian rhythm)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045309"(protein phosphorylated amino acid binding)|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:1990757"(ubiquitin ligase activator activity)|interpro:IPR001680(WD40 repeat)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|interpro:IPR021977|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|interpro:IPR036047|interpro:IPR036322|mint:Q9Y297|rcsb pdb:1P22|rcsb pdb:2P64|rcsb pdb:6M90|rcsb pdb:6M91|rcsb pdb:6M92|rcsb pdb:6M93|rcsb pdb:6M94|go:"GO:0046983"(protein dimerization activity)|rcsb pdb:6TTU|reactome:R-HSA-1169091|reactome:R-HSA-1170546|go:"GO:0048511"(rhythmic process)|reactome:R-HSA-174113|reactome:R-HSA-180534|reactome:R-HSA-195253|reactome:R-HSA-202424|go:"GO:0051726"(regulation of cell cycle)|reactome:R-HSA-2565942|reactome:R-HSA-2871837|reactome:R-HSA-3769402|reactome:R-HSA-400253|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5676590|reactome:R-HSA-5684264|reactome:R-HSA-8951664|reactome:R-HSA-9020702|reactome:R-HSA-983168|dip:DIP-31607N rcsb pdb:3D0V|go:"GO:0016021"(integral component of membrane)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR036179 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/10/11 rogid:9/bXDY6YvJWvP6iMSgOPT9CNGAE9606 rogid:6BDAlrL+rMtscNODLRKimeczMyU9606 intact-crc:C88D00E873055E9C|rigid:zQdZpbQC3mwJxWVbAmO1KYmI+1k false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y297 uniprotkb:O15294 intact:EBI-307461|uniprotkb:Q9Y213|uniprotkb:B5MD49|uniprotkb:Q5W142|ensembl:ENSP00000359206|uniprotkb:Q5W141 intact:EBI-539828|uniprotkb:Q7Z3K0|uniprotkb:Q8WWM8|uniprotkb:Q96CC1|uniprotkb:Q9UG57|ensembl:ENSP00000362824 psi-mi:fbw1a_human(display_long)|uniprotkb:BTRC(gene name)|psi-mi:BTRC(display_short)|uniprotkb:BTRCP(gene name synonym)|uniprotkb:FBW1A(gene name synonym)|uniprotkb:FBXW1A(gene name synonym)|uniprotkb:F-box and WD repeats protein beta-TrCP(gene name synonym)|uniprotkb:E3RSIkappaB(gene name synonym)|uniprotkb:pIkappaBalpha-E3 receptor subunit(gene name synonym)|uniprotkb:Epididymis tissue protein Li 2a(gene name synonym) psi-mi:ogt1_human(display_long)|uniprotkb:O-linked N-acetylglucosamine transferase 110 kDa subunit(gene name synonym)|uniprotkb:O-GlcNAc transferase subunit p110(gene name synonym)|uniprotkb:OGT(gene name)|psi-mi:OGT(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514141|imex:IM-12079-89 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003930.1|refseq:NP_378663.1|ensembl:ENSG00000166167(gene)|ensembl:ENST00000370187(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016874"(ligase activity)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031648"(protein destabilization)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042753"(positive regulation of circadian rhythm)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045309"(protein phosphorylated amino acid binding)|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:1990757"(ubiquitin ligase activator activity)|interpro:IPR001680(WD40 repeat)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|interpro:IPR021977|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|interpro:IPR036047|interpro:IPR036322|mint:Q9Y297|rcsb pdb:1P22|rcsb pdb:2P64|rcsb pdb:6M90|rcsb pdb:6M91|rcsb pdb:6M92|rcsb pdb:6M93|rcsb pdb:6M94|go:"GO:0046983"(protein dimerization activity)|rcsb pdb:6TTU|reactome:R-HSA-1169091|reactome:R-HSA-1170546|go:"GO:0048511"(rhythmic process)|reactome:R-HSA-174113|reactome:R-HSA-180534|reactome:R-HSA-195253|reactome:R-HSA-202424|go:"GO:0051726"(regulation of cell cycle)|reactome:R-HSA-2565942|reactome:R-HSA-2871837|reactome:R-HSA-3769402|reactome:R-HSA-400253|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5676590|reactome:R-HSA-5684264|reactome:R-HSA-8951664|reactome:R-HSA-9020702|reactome:R-HSA-983168|dip:DIP-31607N refseq:NP_858058.1|refseq:NP_858059.1|rcsb pdb:3PE3|rcsb pdb:3PE4|rcsb pdb:3TAX|rcsb pdb:4AY5|rcsb pdb:4AY6|rcsb pdb:4CDR|rcsb pdb:4GYW|rcsb pdb:4GYY|rcsb pdb:4GZ3|rcsb pdb:4GZ5|rcsb pdb:4GZ6|rcsb pdb:4N39|rcsb pdb:4N3A|rcsb pdb:1W3B|rcsb pdb:4N3B|rcsb pdb:4N3C|rcsb pdb:4XI9|rcsb pdb:4XIF|rcsb pdb:5BNW|rcsb pdb:5C1D|rcsb pdb:5HGV|rcsb pdb:5LVV|rcsb pdb:5LWV|rcsb pdb:5NPR|rcsb pdb:5NPS|rcsb pdb:5VIE|rcsb pdb:5VIF|rcsb pdb:6E37|rcsb pdb:6EOU|rcsb pdb:6IBO|rcsb pdb:6MA2|rcsb pdb:6MA3|rcsb pdb:6MA4|rcsb pdb:6MA5|rcsb pdb:6Q4M|rcsb pdb:6TKA|reactome:R-HSA-3214847|reactome:R-HSA-5213460|reactome:R-HSA-5675482|reactome:R-HSA-5689603|rcsb pdb:6MA1|ensembl:ENSG00000147162(gene)|ensembl:ENST00000373719(transcript)|go:"GO:0000123"(histone acetyltransferase complex)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006110"(regulation of glycolytic process)|go:"GO:0006111"(regulation of gluconeogenesis)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006493"(protein O-linked glycosylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007584"(response to nutrient)|go:"GO:0008375"(acetylglucosaminyltransferase activity)|go:"GO:0016262"(protein N-acetylglucosaminyltransferase activity)|go:"GO:0016485"(protein processing)|go:"GO:0017122"(protein N-acetylglucosaminyltransferase complex)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032868"(response to insulin)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035020"(regulation of Rac protein signal transduction)|go:"GO:0043981"(histone H4-K5 acetylation)|go:"GO:0043982"(histone H4-K8 acetylation)|go:"GO:0043984"(histone H4-K16 acetylation)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0060544"(regulation of necroptotic process)|go:"GO:0061087"(positive regulation of histone H3-K27 methylation)|go:"GO:0080182"(histone H3-K4 trimethylation)|go:"GO:0097363"(protein O-GlcNAc transferase activity)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR029489|interpro:IPR037919|mint:O15294|go:"GO:0042995"(cell projection)|refseq:XP_016885396.1|refseq:XP_016885397.1|dip:DIP-33491N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/10/11 rogid:9/bXDY6YvJWvP6iMSgOPT9CNGAE9606 rogid:NmuVFHeg1QRYMbVav6e7fRJft5U9606 intact-crc:C88D00E873055E9C|rigid:zQdZpbQC3mwJxWVbAmO1KYmI+1k false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y297 uniprotkb:P15822 intact:EBI-307461|uniprotkb:Q9Y213|uniprotkb:B5MD49|uniprotkb:Q5W142|ensembl:ENSP00000359206|uniprotkb:Q5W141 intact:EBI-722264|uniprotkb:Q14122|uniprotkb:Q5VW60|uniprotkb:B2RTU3|uniprotkb:Q5MPB1|ensembl:ENSP00000368698 psi-mi:fbw1a_human(display_long)|uniprotkb:BTRC(gene name)|psi-mi:BTRC(display_short)|uniprotkb:BTRCP(gene name synonym)|uniprotkb:FBW1A(gene name synonym)|uniprotkb:FBXW1A(gene name synonym)|uniprotkb:F-box and WD repeats protein beta-TrCP(gene name synonym)|uniprotkb:E3RSIkappaB(gene name synonym)|uniprotkb:pIkappaBalpha-E3 receptor subunit(gene name synonym)|uniprotkb:Epididymis tissue protein Li 2a(gene name synonym) psi-mi:zep1_human(display_long)|uniprotkb:Human immunodeficiency virus type I enhancer-binding protein 1(gene name synonym)|uniprotkb:Major histocompatibility complex-binding protein 1(gene name synonym)|uniprotkb:Positive regulatory domain II-binding factor 1(gene name synonym)|uniprotkb:HIVEP1(gene name)|psi-mi:HIVEP1(display_short)|uniprotkb:ZNF40(gene name synonym)|uniprotkb:Gate keeper of apoptosis-activating protein(gene name synonym)|uniprotkb:Cirhin interaction protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514141|imex:IM-12079-89 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003930.1|refseq:NP_378663.1|ensembl:ENSG00000166167(gene)|ensembl:ENST00000370187(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016874"(ligase activity)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031648"(protein destabilization)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042753"(positive regulation of circadian rhythm)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045309"(protein phosphorylated amino acid binding)|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:1990757"(ubiquitin ligase activator activity)|interpro:IPR001680(WD40 repeat)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|interpro:IPR021977|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|interpro:IPR036047|interpro:IPR036322|mint:Q9Y297|rcsb pdb:1P22|rcsb pdb:2P64|rcsb pdb:6M90|rcsb pdb:6M91|rcsb pdb:6M92|rcsb pdb:6M93|rcsb pdb:6M94|go:"GO:0046983"(protein dimerization activity)|rcsb pdb:6TTU|reactome:R-HSA-1169091|reactome:R-HSA-1170546|go:"GO:0048511"(rhythmic process)|reactome:R-HSA-174113|reactome:R-HSA-180534|reactome:R-HSA-195253|reactome:R-HSA-202424|go:"GO:0051726"(regulation of cell cycle)|reactome:R-HSA-2565942|reactome:R-HSA-2871837|reactome:R-HSA-3769402|reactome:R-HSA-400253|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5676590|reactome:R-HSA-5684264|reactome:R-HSA-8951664|reactome:R-HSA-9020702|reactome:R-HSA-983168|dip:DIP-31607N refseq:NP_002105.3|ensembl:ENSG00000095951(gene)|ensembl:ENST00000379388(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0016604"(nuclear body)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR034729|interpro:IPR036236|mint:P15822|rcsb pdb:1BBO|rcsb pdb:3ZNF|rcsb pdb:4ZNF psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/10/11 rogid:9/bXDY6YvJWvP6iMSgOPT9CNGAE9606 rogid:rugwzqsTO0X8mJ5Zy3msTqc6dr09606 intact-crc:C88D00E873055E9C|rigid:zQdZpbQC3mwJxWVbAmO1KYmI+1k false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y297 uniprotkb:Q96K76 intact:EBI-307461|uniprotkb:Q9Y213|uniprotkb:B5MD49|uniprotkb:Q5W142|ensembl:ENSP00000359206|uniprotkb:Q5W141 intact:EBI-2514143|ensembl:ENSP00000382382|uniprotkb:Q86Y73|uniprotkb:Q9NWN1|uniprotkb:Q9BWI0|uniprotkb:Q8TEP6|uniprotkb:Q658U0|intact:EBI-11020736|uniprotkb:B3KXF5|uniprotkb:E9PM46 psi-mi:fbw1a_human(display_long)|uniprotkb:BTRC(gene name)|psi-mi:BTRC(display_short)|uniprotkb:BTRCP(gene name synonym)|uniprotkb:FBW1A(gene name synonym)|uniprotkb:FBXW1A(gene name synonym)|uniprotkb:F-box and WD repeats protein beta-TrCP(gene name synonym)|uniprotkb:E3RSIkappaB(gene name synonym)|uniprotkb:pIkappaBalpha-E3 receptor subunit(gene name synonym)|uniprotkb:Epididymis tissue protein Li 2a(gene name synonym) psi-mi:ubp47_human(display_long)|uniprotkb:USP47(gene name)|psi-mi:USP47(display_short)|uniprotkb:Ubiquitin-specific-processing protease 47(gene name synonym)|uniprotkb:Deubiquitinating enzyme 47(gene name synonym)|uniprotkb:Ubiquitin thioesterase 47(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514141|imex:IM-12079-89 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003930.1|refseq:NP_378663.1|ensembl:ENSG00000166167(gene)|ensembl:ENST00000370187(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016874"(ligase activity)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031648"(protein destabilization)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042753"(positive regulation of circadian rhythm)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045309"(protein phosphorylated amino acid binding)|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:1990757"(ubiquitin ligase activator activity)|interpro:IPR001680(WD40 repeat)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|interpro:IPR021977|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|interpro:IPR036047|interpro:IPR036322|mint:Q9Y297|rcsb pdb:1P22|rcsb pdb:2P64|rcsb pdb:6M90|rcsb pdb:6M91|rcsb pdb:6M92|rcsb pdb:6M93|rcsb pdb:6M94|go:"GO:0046983"(protein dimerization activity)|rcsb pdb:6TTU|reactome:R-HSA-1169091|reactome:R-HSA-1170546|go:"GO:0048511"(rhythmic process)|reactome:R-HSA-174113|reactome:R-HSA-180534|reactome:R-HSA-195253|reactome:R-HSA-202424|go:"GO:0051726"(regulation of cell cycle)|reactome:R-HSA-2565942|reactome:R-HSA-2871837|reactome:R-HSA-3769402|reactome:R-HSA-400253|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5676590|reactome:R-HSA-5684264|reactome:R-HSA-8951664|reactome:R-HSA-9020702|reactome:R-HSA-983168|dip:DIP-31607N refseq:NP_001269588.1|ensembl:ENSG00000170242(gene)|ensembl:ENST00000399455(transcript)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006284"(base-excision repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010972"(negative regulation of G2/M transition of mitotic cell cycle)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035520"(monoubiquitinated protein deubiquitination)|go:"GO:0042493"|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0071987"(WD40-repeat domain binding)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0101005"(deubiquitinase activity)|go:"GO:1902230"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR029071|interpro:IPR038765|mint:Q96K76|reactome:R-HSA-5689880|refseq:NP_001317137.1|refseq:NP_060414.3|dip:DIP-53629N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/10/11 rogid:9/bXDY6YvJWvP6iMSgOPT9CNGAE9606 rogid:XPhYwHpj4bDPhA/uMESoVswI6Jo9606 intact-crc:C88D00E873055E9C|rigid:zQdZpbQC3mwJxWVbAmO1KYmI+1k false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y297 uniprotkb:O43847 intact:EBI-307461|uniprotkb:Q9Y213|uniprotkb:B5MD49|uniprotkb:Q5W142|ensembl:ENSP00000359206|uniprotkb:Q5W141 intact:EBI-2371631|uniprotkb:O15241|uniprotkb:O15242|uniprotkb:Q5VUL0|uniprotkb:Q96HB2|uniprotkb:Q9NU57|uniprotkb:A6NI41|ensembl:ENSP00000262679|intact:EBI-6137671 psi-mi:fbw1a_human(display_long)|uniprotkb:BTRC(gene name)|psi-mi:BTRC(display_short)|uniprotkb:BTRCP(gene name synonym)|uniprotkb:FBW1A(gene name synonym)|uniprotkb:FBXW1A(gene name synonym)|uniprotkb:F-box and WD repeats protein beta-TrCP(gene name synonym)|uniprotkb:E3RSIkappaB(gene name synonym)|uniprotkb:pIkappaBalpha-E3 receptor subunit(gene name synonym)|uniprotkb:Epididymis tissue protein Li 2a(gene name synonym) psi-mi:nrdc_human(display_long)|uniprotkb:NRDC(gene name)|psi-mi:NRDC(display_short)|uniprotkb:N-arginine dibasic convertase(gene name synonym)|uniprotkb:NRD1(gene name synonym)|uniprotkb:Nardilysin convertase(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514141|imex:IM-12079-89 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003930.1|refseq:NP_378663.1|ensembl:ENSG00000166167(gene)|ensembl:ENST00000370187(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016874"(ligase activity)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031648"(protein destabilization)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042753"(positive regulation of circadian rhythm)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045309"(protein phosphorylated amino acid binding)|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:1990757"(ubiquitin ligase activator activity)|interpro:IPR001680(WD40 repeat)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|interpro:IPR021977|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|interpro:IPR036047|interpro:IPR036322|mint:Q9Y297|rcsb pdb:1P22|rcsb pdb:2P64|rcsb pdb:6M90|rcsb pdb:6M91|rcsb pdb:6M92|rcsb pdb:6M93|rcsb pdb:6M94|go:"GO:0046983"(protein dimerization activity)|rcsb pdb:6TTU|reactome:R-HSA-1169091|reactome:R-HSA-1170546|go:"GO:0048511"(rhythmic process)|reactome:R-HSA-174113|reactome:R-HSA-180534|reactome:R-HSA-195253|reactome:R-HSA-202424|go:"GO:0051726"(regulation of cell cycle)|reactome:R-HSA-2565942|reactome:R-HSA-2871837|reactome:R-HSA-3769402|reactome:R-HSA-400253|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5676590|reactome:R-HSA-5684264|reactome:R-HSA-8951664|reactome:R-HSA-9020702|reactome:R-HSA-983168|dip:DIP-31607N refseq:NP_001095132.1|refseq:NP_001229290.1|refseq:NP_002516.2|ensembl:ENSG00000078618(gene)|ensembl:ENST00000352171(transcript)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0009986"(cell surface)|go:"GO:0046872"(metal ion binding)|go:"GO:0048408"(epidermal growth factor binding)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0052548"(regulation of endopeptidase activity)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|interpro:IPR001431(Peptidase M16, zinc-binding site)|interpro:IPR007863(Peptidase M16, C-terminal)|interpro:IPR011249(Metalloenzyme, LuxS/M16 peptidase-like, metal-binding)|interpro:IPR011765(Peptidase M16, N-terminal)|interpro:IPR032632|mint:O43847 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/10/11 rogid:9/bXDY6YvJWvP6iMSgOPT9CNGAE9606 rogid:zvZTk2Q799M8nsREOYmuYPF/x1U9606 intact-crc:C88D00E873055E9C|rigid:zQdZpbQC3mwJxWVbAmO1KYmI+1k false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y297 uniprotkb:Q6PGQ7 intact:EBI-307461|uniprotkb:Q9Y213|uniprotkb:B5MD49|uniprotkb:Q5W142|ensembl:ENSP00000359206|uniprotkb:Q5W141 intact:EBI-719836|uniprotkb:Q5W0P3|uniprotkb:Q5W0P4|uniprotkb:Q86YC6|uniprotkb:Q96IW9|uniprotkb:Q9H640|intact:EBI-2560951|ensembl:ENSP00000375082|ensembl:ENSP00000498664|uniprotkb:B4DQ30 psi-mi:fbw1a_human(display_long)|uniprotkb:BTRC(gene name)|psi-mi:BTRC(display_short)|uniprotkb:BTRCP(gene name synonym)|uniprotkb:FBW1A(gene name synonym)|uniprotkb:FBXW1A(gene name synonym)|uniprotkb:F-box and WD repeats protein beta-TrCP(gene name synonym)|uniprotkb:E3RSIkappaB(gene name synonym)|uniprotkb:pIkappaBalpha-E3 receptor subunit(gene name synonym)|uniprotkb:Epididymis tissue protein Li 2a(gene name synonym) psi-mi:bora_human(display_long)|uniprotkb:BORA(gene name)|psi-mi:BORA(display_short)|uniprotkb:C13orf34(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514141|imex:IM-12079-89 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003930.1|refseq:NP_378663.1|ensembl:ENSG00000166167(gene)|ensembl:ENST00000370187(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016874"(ligase activity)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031648"(protein destabilization)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042753"(positive regulation of circadian rhythm)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045309"(protein phosphorylated amino acid binding)|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:1990757"(ubiquitin ligase activator activity)|interpro:IPR001680(WD40 repeat)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|interpro:IPR021977|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|interpro:IPR036047|interpro:IPR036322|mint:Q9Y297|rcsb pdb:1P22|rcsb pdb:2P64|rcsb pdb:6M90|rcsb pdb:6M91|rcsb pdb:6M92|rcsb pdb:6M93|rcsb pdb:6M94|go:"GO:0046983"(protein dimerization activity)|rcsb pdb:6TTU|reactome:R-HSA-1169091|reactome:R-HSA-1170546|go:"GO:0048511"(rhythmic process)|reactome:R-HSA-174113|reactome:R-HSA-180534|reactome:R-HSA-195253|reactome:R-HSA-202424|go:"GO:0051726"(regulation of cell cycle)|reactome:R-HSA-2565942|reactome:R-HSA-2871837|reactome:R-HSA-3769402|reactome:R-HSA-400253|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5676590|reactome:R-HSA-5684264|reactome:R-HSA-8951664|reactome:R-HSA-9020702|reactome:R-HSA-983168|dip:DIP-31607N ensembl:ENSG00000136122(gene)|ensembl:ENST00000390667(transcript)|ensembl:ENST00000651477(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0051301"(cell division)|go:"GO:0060236"(regulation of mitotic spindle organization)|go:"GO:0072687"(meiotic spindle)|interpro:IPR023252|reactome:R-HSA-2565942|refseq:NP_001273675.1|refseq:NP_001273676.1|refseq:NP_079084.3|dip:DIP-53424N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/10/11 rogid:9/bXDY6YvJWvP6iMSgOPT9CNGAE9606 rogid:NnEXfCqCEQPKk7KG1RiJyxHrgg09606 intact-crc:C88D00E873055E9C|rigid:zQdZpbQC3mwJxWVbAmO1KYmI+1k false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y297 uniprotkb:Q9BSJ2 intact:EBI-307461|uniprotkb:Q9Y213|uniprotkb:B5MD49|uniprotkb:Q5W142|ensembl:ENSP00000359206|uniprotkb:Q5W141 intact:EBI-357881|uniprotkb:O43632|ensembl:ENSP00000252936|ensembl:ENSP00000506731|ensembl:ENSP00000507482|ensembl:ENSP00000507610|uniprotkb:Q5VWX7|uniprotkb:B4DM18|uniprotkb:F5H4E0|uniprotkb:B7ZKL8|uniprotkb:F5H4L0 psi-mi:fbw1a_human(display_long)|uniprotkb:BTRC(gene name)|psi-mi:BTRC(display_short)|uniprotkb:BTRCP(gene name synonym)|uniprotkb:FBW1A(gene name synonym)|uniprotkb:FBXW1A(gene name synonym)|uniprotkb:F-box and WD repeats protein beta-TrCP(gene name synonym)|uniprotkb:E3RSIkappaB(gene name synonym)|uniprotkb:pIkappaBalpha-E3 receptor subunit(gene name synonym)|uniprotkb:Epididymis tissue protein Li 2a(gene name synonym) psi-mi:gcp2_human(display_long)|uniprotkb:TUBGCP2(gene name)|psi-mi:TUBGCP2(display_short)|uniprotkb:GCP2(gene name synonym)|uniprotkb:Spindle pole body protein Spc97 homolog(gene name synonym)|uniprotkb:Gamma-ring complex protein 103 kDa(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514141|imex:IM-12079-89 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003930.1|refseq:NP_378663.1|ensembl:ENSG00000166167(gene)|ensembl:ENST00000370187(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016874"(ligase activity)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031648"(protein destabilization)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042753"(positive regulation of circadian rhythm)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045309"(protein phosphorylated amino acid binding)|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:1990757"(ubiquitin ligase activator activity)|interpro:IPR001680(WD40 repeat)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|interpro:IPR021977|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|interpro:IPR036047|interpro:IPR036322|mint:Q9Y297|rcsb pdb:1P22|rcsb pdb:2P64|rcsb pdb:6M90|rcsb pdb:6M91|rcsb pdb:6M92|rcsb pdb:6M93|rcsb pdb:6M94|go:"GO:0046983"(protein dimerization activity)|rcsb pdb:6TTU|reactome:R-HSA-1169091|reactome:R-HSA-1170546|go:"GO:0048511"(rhythmic process)|reactome:R-HSA-174113|reactome:R-HSA-180534|reactome:R-HSA-195253|reactome:R-HSA-202424|go:"GO:0051726"(regulation of cell cycle)|reactome:R-HSA-2565942|reactome:R-HSA-2871837|reactome:R-HSA-3769402|reactome:R-HSA-400253|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5676590|reactome:R-HSA-5684264|reactome:R-HSA-8951664|reactome:R-HSA-9020702|reactome:R-HSA-983168|dip:DIP-31607N refseq:NP_006650.1|ensembl:ENSG00000130640(gene)|ensembl:ENST00000252936(transcript)|ensembl:ENST00000682123(transcript)|ensembl:ENST00000682515(transcript)|ensembl:ENST00000683612(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000922"(spindle pole)|go:"GO:0000923"(equatorial microtubule organizing center)|go:"GO:0000930"(gamma-tubulin complex)|go:"GO:0001764"(neuron migration)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005815"(microtubule organizing center)|refseq:NP_001243547.1|refseq:NP_001243546.1|go:"GO:0005829"(cytosol)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0007020"(microtubule nucleation)|go:"GO:0007420"(brain development)|go:"GO:0008275"(gamma-tubulin small complex)|go:"GO:0016020"(membrane)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0051225"(spindle assembly)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0065003"(protein-containing complex assembly)|interpro:IPR007259(Spc97/Spc98)|interpro:IPR040457|interpro:IPR041470|mint:Q9BSJ2|rcsb pdb:6V6B|rcsb pdb:6V6S|rcsb pdb:6X0V|rcsb pdb:7AS4|reactome:R-HSA-380270|reactome:R-HSA-380320 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/10/11 rogid:9/bXDY6YvJWvP6iMSgOPT9CNGAE9606 rogid:vhamYv9ZNsZkSBkGQCwVylqx9wE9606 intact-crc:C88D00E873055E9C|rigid:zQdZpbQC3mwJxWVbAmO1KYmI+1k false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y297 uniprotkb:Q13616 intact:EBI-307461|uniprotkb:Q9Y213|uniprotkb:B5MD49|uniprotkb:Q5W142|ensembl:ENSP00000359206|uniprotkb:Q5W141 intact:EBI-359390|uniprotkb:O60719|uniprotkb:Q08AL6|uniprotkb:Q8IYW1|uniprotkb:D3DWG3|ensembl:ENSP00000326804|ensembl:ENSP00000387160|ensembl:ENSP00000473318|ensembl:ENSP00000499255|ensembl:ENSP00000499277|ensembl:ENSP00000499398 psi-mi:fbw1a_human(display_long)|uniprotkb:BTRC(gene name)|psi-mi:BTRC(display_short)|uniprotkb:BTRCP(gene name synonym)|uniprotkb:FBW1A(gene name synonym)|uniprotkb:FBXW1A(gene name synonym)|uniprotkb:F-box and WD repeats protein beta-TrCP(gene name synonym)|uniprotkb:E3RSIkappaB(gene name synonym)|uniprotkb:pIkappaBalpha-E3 receptor subunit(gene name synonym)|uniprotkb:Epididymis tissue protein Li 2a(gene name synonym) psi-mi:cul1_human(display_long)|uniprotkb:CUL1(gene name)|psi-mi:CUL1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514141|imex:IM-12079-89 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003930.1|refseq:NP_378663.1|ensembl:ENSG00000166167(gene)|ensembl:ENST00000370187(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016874"(ligase activity)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031648"(protein destabilization)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042753"(positive regulation of circadian rhythm)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045309"(protein phosphorylated amino acid binding)|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:1990757"(ubiquitin ligase activator activity)|interpro:IPR001680(WD40 repeat)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|interpro:IPR021977|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|interpro:IPR036047|interpro:IPR036322|mint:Q9Y297|rcsb pdb:1P22|rcsb pdb:2P64|rcsb pdb:6M90|rcsb pdb:6M91|rcsb pdb:6M92|rcsb pdb:6M93|rcsb pdb:6M94|go:"GO:0046983"(protein dimerization activity)|rcsb pdb:6TTU|reactome:R-HSA-1169091|reactome:R-HSA-1170546|go:"GO:0048511"(rhythmic process)|reactome:R-HSA-174113|reactome:R-HSA-180534|reactome:R-HSA-195253|reactome:R-HSA-202424|go:"GO:0051726"(regulation of cell cycle)|reactome:R-HSA-2565942|reactome:R-HSA-2871837|reactome:R-HSA-3769402|reactome:R-HSA-400253|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5676590|reactome:R-HSA-5684264|reactome:R-HSA-8951664|reactome:R-HSA-9020702|reactome:R-HSA-983168|dip:DIP-31607N refseq:NP_003583.2|rcsb pdb:6WCQ|rcsb pdb:7B5L|rcsb pdb:7B5M|rcsb pdb:7B5N|rcsb pdb:7B5R|rcsb pdb:7B5S|reactome:R-HSA-1169091|reactome:R-HSA-1170546|reactome:R-HSA-174113|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-2122947|reactome:R-HSA-2565942|reactome:R-HSA-2644606|reactome:R-HSA-2644607|reactome:R-HSA-2871837|reactome:R-HSA-2894862|reactome:R-HSA-400253|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5676590|reactome:R-HSA-5684264|reactome:R-HSA-68949|reactome:R-HSA-69231|reactome:R-HSA-8854050|reactome:R-HSA-8939902|reactome:R-HSA-8951664|reactome:R-HSA-9020702|reactome:R-HSA-917937|reactome:R-HSA-9604323|reactome:R-HSA-9708530|reactome:R-HSA-983168|refseq:XP_011514931.1|refseq:XP_011514932.1|refseq:XP_011514933.1|refseq:XP_011514934.1|ensembl:ENSG00000055130(gene)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|ensembl:ENST00000325222(transcript)|ensembl:ENST00000409469(transcript)|ensembl:ENST00000602748(transcript)|ensembl:ENST00000662716(transcript)|ensembl:ENST00000663044(transcript)|ensembl:ENST00000665936(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:1990452"(Parkin-FBXW7-Cul1 ubiquitin ligase complex)|interpro:IPR001373(Cullin, N-terminal region)|interpro:IPR016157(Cullin, conserved site)|interpro:IPR016158(Cullin homology)|interpro:IPR016159(Cullin repeat-like)|interpro:IPR019559|interpro:IPR036317|interpro:IPR036388|interpro:IPR036390|mint:Q13616|rcsb pdb:1LDJ|rcsb pdb:1LDK|rcsb pdb:1U6G|rcsb pdb:3RTR|rcsb pdb:3TDU|rcsb pdb:3TDZ|rcsb pdb:4F52|rcsb pdb:4P5O|rcsb pdb:5V89|rcsb pdb:6TTU|refseq:XP_005250117.1|dip:DIP-17013N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/10/11 rogid:9/bXDY6YvJWvP6iMSgOPT9CNGAE9606 rogid:OAZP+ifWW3eEnQKb937ww9s1fMQ9606 intact-crc:C88D00E873055E9C|rigid:zQdZpbQC3mwJxWVbAmO1KYmI+1k false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y297 uniprotkb:O76031 intact:EBI-307461|uniprotkb:Q9Y213|uniprotkb:B5MD49|uniprotkb:Q5W142|ensembl:ENSP00000359206|uniprotkb:Q5W141 intact:EBI-1052667|uniprotkb:A1L428|uniprotkb:A8K8F1|uniprotkb:Q9H4D9|uniprotkb:B9EGI8|ensembl:ENSP00000300107 psi-mi:fbw1a_human(display_long)|uniprotkb:BTRC(gene name)|psi-mi:BTRC(display_short)|uniprotkb:BTRCP(gene name synonym)|uniprotkb:FBW1A(gene name synonym)|uniprotkb:FBXW1A(gene name synonym)|uniprotkb:F-box and WD repeats protein beta-TrCP(gene name synonym)|uniprotkb:E3RSIkappaB(gene name synonym)|uniprotkb:pIkappaBalpha-E3 receptor subunit(gene name synonym)|uniprotkb:Epididymis tissue protein Li 2a(gene name synonym) psi-mi:clpx_human(display_long)|uniprotkb:CLPX(gene name)|psi-mi:CLPX(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514141|imex:IM-12079-89 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003930.1|refseq:NP_378663.1|ensembl:ENSG00000166167(gene)|ensembl:ENST00000370187(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016874"(ligase activity)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031648"(protein destabilization)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042753"(positive regulation of circadian rhythm)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045309"(protein phosphorylated amino acid binding)|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:1990757"(ubiquitin ligase activator activity)|interpro:IPR001680(WD40 repeat)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|interpro:IPR021977|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|interpro:IPR036047|interpro:IPR036322|mint:Q9Y297|rcsb pdb:1P22|rcsb pdb:2P64|rcsb pdb:6M90|rcsb pdb:6M91|rcsb pdb:6M92|rcsb pdb:6M93|rcsb pdb:6M94|go:"GO:0046983"(protein dimerization activity)|rcsb pdb:6TTU|reactome:R-HSA-1169091|reactome:R-HSA-1170546|go:"GO:0048511"(rhythmic process)|reactome:R-HSA-174113|reactome:R-HSA-180534|reactome:R-HSA-195253|reactome:R-HSA-202424|go:"GO:0051726"(regulation of cell cycle)|reactome:R-HSA-2565942|reactome:R-HSA-2871837|reactome:R-HSA-3769402|reactome:R-HSA-400253|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5676590|reactome:R-HSA-5684264|reactome:R-HSA-8951664|reactome:R-HSA-9020702|reactome:R-HSA-983168|dip:DIP-31607N refseq:NP_006651.2|ensembl:ENSG00000166855(gene)|ensembl:ENST00000300107(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006508"(proteolysis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009368"(endopeptidase Clp complex)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0030163"(protein catabolic process)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR004487(ClpX, ATPase regulatory subunit)|interpro:IPR010603(Zinc finger, C4-type)|interpro:IPR019489|interpro:IPR027417|go:"GO:0009841"(mitochondrial endopeptidase Clp complex)|mint:O76031|dip:DIP-50293N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/10/11 rogid:9/bXDY6YvJWvP6iMSgOPT9CNGAE9606 rogid:+SOis7raPEZqqeel6Y6dOWJcLj49606 intact-crc:C88D00E873055E9C|rigid:zQdZpbQC3mwJxWVbAmO1KYmI+1k false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y297 uniprotkb:Q9UH99 intact:EBI-307461|uniprotkb:Q9Y213|uniprotkb:B5MD49|uniprotkb:Q5W142|ensembl:ENSP00000359206|uniprotkb:Q5W141 intact:EBI-1044964|uniprotkb:O75156|uniprotkb:Q2NKN8|uniprotkb:Q6B4H1|uniprotkb:Q7Z3E3|uniprotkb:Q2T9F7|ensembl:ENSP00000383992|ensembl:ENSP00000385740|uniprotkb:B0QY62|uniprotkb:Q504T5 psi-mi:fbw1a_human(display_long)|uniprotkb:BTRC(gene name)|psi-mi:BTRC(display_short)|uniprotkb:BTRCP(gene name synonym)|uniprotkb:FBW1A(gene name synonym)|uniprotkb:FBXW1A(gene name synonym)|uniprotkb:F-box and WD repeats protein beta-TrCP(gene name synonym)|uniprotkb:E3RSIkappaB(gene name synonym)|uniprotkb:pIkappaBalpha-E3 receptor subunit(gene name synonym)|uniprotkb:Epididymis tissue protein Li 2a(gene name synonym) psi-mi:sun2_human(display_long)|uniprotkb:Sad1/unc-84 protein-like 2(gene name synonym)|uniprotkb:Rab5-interacting protein(gene name synonym)|uniprotkb:SUN2(gene name)|psi-mi:SUN2(display_short)|uniprotkb:FRIGG(gene name synonym)|uniprotkb:KIAA0668(gene name synonym)|uniprotkb:RAB5IP(gene name synonym)|uniprotkb:UNC84B(gene name synonym)|uniprotkb:Protein unc-84 homolog B(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514141|imex:IM-12079-89 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003930.1|refseq:NP_378663.1|ensembl:ENSG00000166167(gene)|ensembl:ENST00000370187(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016874"(ligase activity)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031648"(protein destabilization)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042753"(positive regulation of circadian rhythm)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045309"(protein phosphorylated amino acid binding)|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:1990757"(ubiquitin ligase activator activity)|interpro:IPR001680(WD40 repeat)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|interpro:IPR021977|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|interpro:IPR036047|interpro:IPR036322|mint:Q9Y297|rcsb pdb:1P22|rcsb pdb:2P64|rcsb pdb:6M90|rcsb pdb:6M91|rcsb pdb:6M92|rcsb pdb:6M93|rcsb pdb:6M94|go:"GO:0046983"(protein dimerization activity)|rcsb pdb:6TTU|reactome:R-HSA-1169091|reactome:R-HSA-1170546|go:"GO:0048511"(rhythmic process)|reactome:R-HSA-174113|reactome:R-HSA-180534|reactome:R-HSA-195253|reactome:R-HSA-202424|go:"GO:0051726"(regulation of cell cycle)|reactome:R-HSA-2565942|reactome:R-HSA-2871837|reactome:R-HSA-3769402|reactome:R-HSA-400253|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5676590|reactome:R-HSA-5684264|reactome:R-HSA-8951664|reactome:R-HSA-9020702|reactome:R-HSA-983168|dip:DIP-31607N refseq:NP_001186508.1|refseq:NP_001186509.1|refseq:NP_056189.1|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0005521"(lamin binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005639"(integral component of nuclear inner membrane)|go:"GO:0006998"(nuclear envelope organization)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007097"(nuclear migration)|go:"GO:0008017"(microtubule binding)|go:"GO:0010008"(endosome membrane)|go:"GO:0021817"(nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031022"(nuclear migration along microfilament)|go:"GO:0031965"(nuclear membrane)|go:"GO:0034993"(meiotic nuclear membrane microtubule tethering complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0051642"(centrosome localization)|go:"GO:0090292"(nuclear matrix anchoring at nuclear membrane)|go:"GO:0140444"(cytoskeleton-nuclear membrane anchor activity)|go:"GO:0000781"(chromosome, telomeric region)|interpro:IPR012919(Sad1/UNC-like, C-terminal)|interpro:IPR030272|interpro:IPR040994|mint:Q9UH99|ensembl:ENSG00000100242(gene)|ensembl:ENST00000405510(transcript)|ensembl:ENST00000406622(transcript)|rcsb pdb:4DXS|rcsb pdb:4DXT|rcsb pdb:4FI9|rcsb pdb:6WMD|rcsb pdb:6WME|rcsb pdb:6WMF|rcsb pdb:6WMG|reactome:R-HSA-1221632|rcsb pdb:4DXR|rcsb pdb:3UNP psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/10/11 rogid:9/bXDY6YvJWvP6iMSgOPT9CNGAE9606 rogid:nG0s5eHv6AGh8rcdhTIJ1RdpfbU9606 intact-crc:C88D00E873055E9C|rigid:zQdZpbQC3mwJxWVbAmO1KYmI+1k false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y297 uniprotkb:P49427 intact:EBI-307461|uniprotkb:Q9Y213|uniprotkb:B5MD49|uniprotkb:Q5W142|ensembl:ENSP00000359206|uniprotkb:Q5W141 intact:EBI-975634|ensembl:ENSP00000215574|uniprotkb:A8K689 psi-mi:fbw1a_human(display_long)|uniprotkb:BTRC(gene name)|psi-mi:BTRC(display_short)|uniprotkb:BTRCP(gene name synonym)|uniprotkb:FBW1A(gene name synonym)|uniprotkb:FBXW1A(gene name synonym)|uniprotkb:F-box and WD repeats protein beta-TrCP(gene name synonym)|uniprotkb:E3RSIkappaB(gene name synonym)|uniprotkb:pIkappaBalpha-E3 receptor subunit(gene name synonym)|uniprotkb:Epididymis tissue protein Li 2a(gene name synonym) psi-mi:ub2r1_human(display_long)|uniprotkb:Ubiquitin-protein ligase R1(gene name synonym)|uniprotkb:Ubiquitin-conjugating enzyme E2-32 kDa complementing(gene name synonym)|uniprotkb:Ubiquitin-conjugating enzyme E2-CDC34(gene name synonym)|uniprotkb:CDC34(gene name)|psi-mi:CDC34(display_short)|uniprotkb:UBE2R1(gene name synonym)|uniprotkb:UBCH3(gene name synonym)|uniprotkb:"(E3-independent) E2 ubiquitin-conjugating enzyme R1"(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme R1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514141|imex:IM-12079-89 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003930.1|refseq:NP_378663.1|ensembl:ENSG00000166167(gene)|ensembl:ENST00000370187(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016874"(ligase activity)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031648"(protein destabilization)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042753"(positive regulation of circadian rhythm)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045309"(protein phosphorylated amino acid binding)|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:1990757"(ubiquitin ligase activator activity)|interpro:IPR001680(WD40 repeat)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|interpro:IPR021977|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|interpro:IPR036047|interpro:IPR036322|mint:Q9Y297|rcsb pdb:1P22|rcsb pdb:2P64|rcsb pdb:6M90|rcsb pdb:6M91|rcsb pdb:6M92|rcsb pdb:6M93|rcsb pdb:6M94|go:"GO:0046983"(protein dimerization activity)|rcsb pdb:6TTU|reactome:R-HSA-1169091|reactome:R-HSA-1170546|go:"GO:0048511"(rhythmic process)|reactome:R-HSA-174113|reactome:R-HSA-180534|reactome:R-HSA-195253|reactome:R-HSA-202424|go:"GO:0051726"(regulation of cell cycle)|reactome:R-HSA-2565942|reactome:R-HSA-2871837|reactome:R-HSA-3769402|reactome:R-HSA-400253|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5676590|reactome:R-HSA-5684264|reactome:R-HSA-8951664|reactome:R-HSA-9020702|reactome:R-HSA-983168|dip:DIP-31607N go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016607"(nuclear speck)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043951"(negative regulation of cAMP-mediated signaling)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070848"(response to growth factor)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0090261"(positive regulation of inclusion body assembly)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|rcsb pdb:2OB4|rcsb pdb:3RZ3|rcsb pdb:4MDK|reactome:R-HSA-202424|reactome:R-HSA-2871837|reactome:R-HSA-5607764|reactome:R-HSA-8866652|reactome:R-HSA-983168|ensembl:ENSG00000099804(gene)|ensembl:ENST00000215574(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|refseq:NP_004350.1|dip:DIP-37783N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/10/11 rogid:9/bXDY6YvJWvP6iMSgOPT9CNGAE9606 rogid:iOYLaiXBmINnd0daIWCr5KVungo9606 intact-crc:C88D00E873055E9C|rigid:zQdZpbQC3mwJxWVbAmO1KYmI+1k false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y297 uniprotkb:Q14145 intact:EBI-307461|uniprotkb:Q9Y213|uniprotkb:B5MD49|uniprotkb:Q5W142|ensembl:ENSP00000359206|uniprotkb:Q5W141 intact:EBI-751001|uniprotkb:B3KPD5|uniprotkb:Q8WTX1|uniprotkb:Q6LEP0|uniprotkb:Q9BPY9|intact:EBI-28976014|ensembl:ENSP00000171111|ensembl:ENSP00000377245 psi-mi:fbw1a_human(display_long)|uniprotkb:BTRC(gene name)|psi-mi:BTRC(display_short)|uniprotkb:BTRCP(gene name synonym)|uniprotkb:FBW1A(gene name synonym)|uniprotkb:FBXW1A(gene name synonym)|uniprotkb:F-box and WD repeats protein beta-TrCP(gene name synonym)|uniprotkb:E3RSIkappaB(gene name synonym)|uniprotkb:pIkappaBalpha-E3 receptor subunit(gene name synonym)|uniprotkb:Epididymis tissue protein Li 2a(gene name synonym) psi-mi:keap1_human(display_long)|uniprotkb:Cytosolic inhibitor of Nrf2(gene name synonym)|uniprotkb:Kelch-like protein 19(gene name synonym)|uniprotkb:KEAP1(gene name)|psi-mi:KEAP1(display_short)|uniprotkb:INRF2(gene name synonym)|uniprotkb:KIAA0132(gene name synonym)|uniprotkb:KLHL19(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514141|imex:IM-12079-89 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003930.1|refseq:NP_378663.1|ensembl:ENSG00000166167(gene)|ensembl:ENST00000370187(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016874"(ligase activity)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031648"(protein destabilization)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042753"(positive regulation of circadian rhythm)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045309"(protein phosphorylated amino acid binding)|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:1990757"(ubiquitin ligase activator activity)|interpro:IPR001680(WD40 repeat)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|interpro:IPR021977|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|interpro:IPR036047|interpro:IPR036322|mint:Q9Y297|rcsb pdb:1P22|rcsb pdb:2P64|rcsb pdb:6M90|rcsb pdb:6M91|rcsb pdb:6M92|rcsb pdb:6M93|rcsb pdb:6M94|go:"GO:0046983"(protein dimerization activity)|rcsb pdb:6TTU|reactome:R-HSA-1169091|reactome:R-HSA-1170546|go:"GO:0048511"(rhythmic process)|reactome:R-HSA-174113|reactome:R-HSA-180534|reactome:R-HSA-195253|reactome:R-HSA-202424|go:"GO:0051726"(regulation of cell cycle)|reactome:R-HSA-2565942|reactome:R-HSA-2871837|reactome:R-HSA-3769402|reactome:R-HSA-400253|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5676590|reactome:R-HSA-5684264|reactome:R-HSA-8951664|reactome:R-HSA-9020702|reactome:R-HSA-983168|dip:DIP-31607N refseq:NP_036421.2|refseq:NP_987096.1|ensembl:ENSP00000171111|ensembl:ENSP00000377245|refseq:XP_011526754.1|refseq:XP_005260230.1|refseq:XP_005260231.1|dip:DIP-42134N|ensembl:ENSG00000079999(gene)|ensembl:ENST00000171111(transcript)|ensembl:ENST00000393623(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016234"(inclusion body)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030496"(midbody)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0042802"(identical protein binding)|go:"GO:0042994"(cytoplasmic sequestering of transcription factor)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045604"(regulation of epidermal cell differentiation)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0097718"(disordered domain specific binding)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR011705(BTB/Kelch-associated)|interpro:IPR015915(Kelch-type beta propeller)|interpro:IPR017096(Kelch-like protein, gigaxonin)|interpro:IPR030563|mint:Q14145|rcsb pdb:1U6D|rcsb pdb:1ZGK|rcsb pdb:2FLU|rcsb pdb:3VNG|rcsb pdb:3VNH|rcsb pdb:3ZGC|rcsb pdb:3ZGD|rcsb pdb:4CXI|rcsb pdb:4CXJ|rcsb pdb:4CXT|rcsb pdb:4IFJ|rcsb pdb:4IFL|rcsb pdb:4IFN|rcsb pdb:4IN4|rcsb pdb:4IQK|rcsb pdb:4L7B|rcsb pdb:4L7C|rcsb pdb:4L7D|rcsb pdb:4N1B|rcsb pdb:4XMB|rcsb pdb:5DAD|rcsb pdb:5DAF|rcsb pdb:5F72|rcsb pdb:5GIT|rcsb pdb:5NLB|rcsb pdb:5WFL|rcsb pdb:5WFV|rcsb pdb:5WG1|rcsb pdb:5WHL|rcsb pdb:5WHO|rcsb pdb:5WIY|rcsb pdb:5X54|rcsb pdb:6FFM|rcsb pdb:6FMP|rcsb pdb:6FMQ|rcsb pdb:6HWS|rcsb pdb:6LRZ|rcsb pdb:6ROG|rcsb pdb:6SP1|rcsb pdb:6SP4|rcsb pdb:6T7V|rcsb pdb:6T7Z|rcsb pdb:6TG8|rcsb pdb:6TYM|rcsb pdb:6TYP|rcsb pdb:6UF0|rcsb pdb:6W66|rcsb pdb:6W67|rcsb pdb:6W68|rcsb pdb:6W69|rcsb pdb:6WCQ|rcsb pdb:6Z6A|rcsb pdb:7K28|rcsb pdb:7K29|rcsb pdb:7K2A|rcsb pdb:7K2B|rcsb pdb:7K2C|rcsb pdb:7K2D|rcsb pdb:7K2E|rcsb pdb:7K2F|rcsb pdb:7K2G|rcsb pdb:7K2H|rcsb pdb:7K2I|rcsb pdb:7K2J|rcsb pdb:7K2K|rcsb pdb:7K2L|rcsb pdb:7K2M|rcsb pdb:7K2N|rcsb pdb:7K2O|rcsb pdb:7K2P|rcsb pdb:7K2Q|rcsb pdb:7K2R|rcsb pdb:7K2S|reactome:R-HSA-5689880|reactome:R-HSA-8932339|reactome:R-HSA-8951664|reactome:R-HSA-983168|rcsb pdb:6V6Z psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/10/11 rogid:9/bXDY6YvJWvP6iMSgOPT9CNGAE9606 rogid:3y/KqnUK+5nIyjhOEfkkthmP1OA9606 intact-crc:C88D00E873055E9C|rigid:zQdZpbQC3mwJxWVbAmO1KYmI+1k false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y297 uniprotkb:P25054 intact:EBI-307461|uniprotkb:Q9Y213|uniprotkb:B5MD49|uniprotkb:Q5W142|ensembl:ENSP00000359206|uniprotkb:Q5W141 intact:EBI-727707|uniprotkb:Q15162|uniprotkb:Q15163|uniprotkb:Q93042|uniprotkb:D3DT03|uniprotkb:B7Z2B6|ensembl:ENSP00000257430|ensembl:ENSP00000427089 psi-mi:fbw1a_human(display_long)|uniprotkb:BTRC(gene name)|psi-mi:BTRC(display_short)|uniprotkb:BTRCP(gene name synonym)|uniprotkb:FBW1A(gene name synonym)|uniprotkb:FBXW1A(gene name synonym)|uniprotkb:F-box and WD repeats protein beta-TrCP(gene name synonym)|uniprotkb:E3RSIkappaB(gene name synonym)|uniprotkb:pIkappaBalpha-E3 receptor subunit(gene name synonym)|uniprotkb:Epididymis tissue protein Li 2a(gene name synonym) psi-mi:apc_human(display_long)|uniprotkb:APC(gene name)|psi-mi:APC(display_short)|uniprotkb:DP2.5(gene name synonym)|uniprotkb:Deleted in polyposis 2.5(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514141|imex:IM-12079-89 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003930.1|refseq:NP_378663.1|ensembl:ENSG00000166167(gene)|ensembl:ENST00000370187(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016874"(ligase activity)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031648"(protein destabilization)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042753"(positive regulation of circadian rhythm)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045309"(protein phosphorylated amino acid binding)|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:1990757"(ubiquitin ligase activator activity)|interpro:IPR001680(WD40 repeat)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|interpro:IPR021977|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|interpro:IPR036047|interpro:IPR036322|mint:Q9Y297|rcsb pdb:1P22|rcsb pdb:2P64|rcsb pdb:6M90|rcsb pdb:6M91|rcsb pdb:6M92|rcsb pdb:6M93|rcsb pdb:6M94|go:"GO:0046983"(protein dimerization activity)|rcsb pdb:6TTU|reactome:R-HSA-1169091|reactome:R-HSA-1170546|go:"GO:0048511"(rhythmic process)|reactome:R-HSA-174113|reactome:R-HSA-180534|reactome:R-HSA-195253|reactome:R-HSA-202424|go:"GO:0051726"(regulation of cell cycle)|reactome:R-HSA-2565942|reactome:R-HSA-2871837|reactome:R-HSA-3769402|reactome:R-HSA-400253|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5676590|reactome:R-HSA-5684264|reactome:R-HSA-8951664|reactome:R-HSA-9020702|reactome:R-HSA-983168|dip:DIP-31607N refseq:NP_000029.2|refseq:NP_001120982.1|dip:DIP-33556N|refseq:NP_001120983.2|ensembl:ENSG00000134982(gene)|ensembl:ENST00000257430(transcript)|ensembl:ENST00000508376(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000776"(kinetochore)|go:"GO:0001708"(cell fate specification)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007155"(cell adhesion)|go:"GO:0007389"(pattern specification process)|go:"GO:0007399"(nervous system development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008017"(microtubule binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016342"(catenin complex)|go:"GO:0016477"(cell migration)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031274"(positive regulation of pseudopodium assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051988"(regulation of attachment of spindle microtubules to kinetochore)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0070840"(dynein complex binding)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1904781"(positive regulation of protein localization to centrosome)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR000225(Armadillo)|interpro:IPR009223(APC cysteine-rich)|interpro:IPR009224(SAMP)|interpro:IPR009232(EB-1 binding)|interpro:IPR009234(APC basic)|interpro:IPR009240(APC 15 residue)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR026818|interpro:IPR026831|interpro:IPR026836|interpro:IPR032038|interpro:IPR036149|interpro:IPR041257|mint:P25054|rcsb pdb:1DEB|rcsb pdb:1EMU|rcsb pdb:1JPP|rcsb pdb:1M5I|rcsb pdb:1T08|rcsb pdb:1TH1|rcsb pdb:1V18|rcsb pdb:2RQU|rcsb pdb:3AU3|rcsb pdb:3NMW|rcsb pdb:3NMX|rcsb pdb:3NMZ|rcsb pdb:3QHE|rcsb pdb:3RL7|rcsb pdb:3RL8|rcsb pdb:3T7U|rcsb pdb:4G69|rcsb pdb:4YJE|rcsb pdb:4YJL|rcsb pdb:4YK6|rcsb pdb:5B6G|rcsb pdb:5IZ6|rcsb pdb:5IZ8|rcsb pdb:5IZ9|rcsb pdb:5IZA|rcsb pdb:5Z8H|reactome:R-HSA-111465|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-3769402|reactome:R-HSA-4641262|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5467333|reactome:R-HSA-5467337|reactome:R-HSA-5467340|reactome:R-HSA-5467348|reactome:R-HSA-5689896 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/10/11 rogid:9/bXDY6YvJWvP6iMSgOPT9CNGAE9606 rogid:BLZJqb4+lTr7gs2vgkXMvuwG+KU9606 intact-crc:C88D00E873055E9C|rigid:zQdZpbQC3mwJxWVbAmO1KYmI+1k false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y297 uniprotkb:Q9BT78 intact:EBI-307461|uniprotkb:Q9Y213|uniprotkb:B5MD49|uniprotkb:Q5W142|ensembl:ENSP00000359206|uniprotkb:Q5W141 intact:EBI-742413|uniprotkb:Q561W7|uniprotkb:Q9NW31|uniprotkb:Q9Y677|uniprotkb:B3KN88|ensembl:ENSP00000264389|uniprotkb:B3KST5 psi-mi:fbw1a_human(display_long)|uniprotkb:BTRC(gene name)|psi-mi:BTRC(display_short)|uniprotkb:BTRCP(gene name synonym)|uniprotkb:FBW1A(gene name synonym)|uniprotkb:FBXW1A(gene name synonym)|uniprotkb:F-box and WD repeats protein beta-TrCP(gene name synonym)|uniprotkb:E3RSIkappaB(gene name synonym)|uniprotkb:pIkappaBalpha-E3 receptor subunit(gene name synonym)|uniprotkb:Epididymis tissue protein Li 2a(gene name synonym) psi-mi:csn4_human(display_long)|uniprotkb:COPS4(gene name)|psi-mi:COPS4(display_short)|uniprotkb:CSN4(gene name synonym)|uniprotkb:JAB1-containing signalosome subunit 4(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514141|imex:IM-12079-89 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003930.1|refseq:NP_378663.1|ensembl:ENSG00000166167(gene)|ensembl:ENST00000370187(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016874"(ligase activity)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031648"(protein destabilization)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042753"(positive regulation of circadian rhythm)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045309"(protein phosphorylated amino acid binding)|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:1990757"(ubiquitin ligase activator activity)|interpro:IPR001680(WD40 repeat)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|interpro:IPR021977|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|interpro:IPR036047|interpro:IPR036322|mint:Q9Y297|rcsb pdb:1P22|rcsb pdb:2P64|rcsb pdb:6M90|rcsb pdb:6M91|rcsb pdb:6M92|rcsb pdb:6M93|rcsb pdb:6M94|go:"GO:0046983"(protein dimerization activity)|rcsb pdb:6TTU|reactome:R-HSA-1169091|reactome:R-HSA-1170546|go:"GO:0048511"(rhythmic process)|reactome:R-HSA-174113|reactome:R-HSA-180534|reactome:R-HSA-195253|reactome:R-HSA-202424|go:"GO:0051726"(regulation of cell cycle)|reactome:R-HSA-2565942|reactome:R-HSA-2871837|reactome:R-HSA-3769402|reactome:R-HSA-400253|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5676590|reactome:R-HSA-5684264|reactome:R-HSA-8951664|reactome:R-HSA-9020702|reactome:R-HSA-983168|dip:DIP-31607N ensembl:ENSG00000138663(gene)|refseq:NP_057213.2|refseq:NP_001244935.1|go:"GO:0016607"(nuclear speck)|go:"GO:0019784"(NEDD8-specific protease activity)|go:"GO:0030054"(cell junction)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR036388|interpro:IPR036390|interpro:IPR037754|interpro:IPR040134|interpro:IPR041406|mint:Q9BT78|rcsb pdb:4D0P|rcsb pdb:4D10|rcsb pdb:4D18|rcsb pdb:4WSN|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|rcsb pdb:6R7N|reactome:R-HSA-5696394|reactome:R-HSA-6781823|reactome:R-HSA-8856825|reactome:R-HSA-8951664|reactome:R-HSA-9013422|ensembl:ENST00000264389(transcript)|go:"GO:0000338"(protein deneddylation)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008180"(COP9 signalosome)|refseq:NP_001317656.1|dip:DIP-34516N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/10/11 rogid:9/bXDY6YvJWvP6iMSgOPT9CNGAE9606 rogid:onrZiPzG+bZvycmpDTZMtkPzCfQ9606 intact-crc:C88D00E873055E9C|rigid:zQdZpbQC3mwJxWVbAmO1KYmI+1k false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y297 uniprotkb:Q9UKB1 intact:EBI-307461|uniprotkb:Q9Y213|uniprotkb:B5MD49|uniprotkb:Q5W142|ensembl:ENSP00000359206|uniprotkb:Q5W141 intact:EBI-355189|uniprotkb:Q9P2S8|uniprotkb:Q9P2S9|uniprotkb:Q9Y4C6|uniprotkb:B2RC98|ensembl:ENSP00000265094 psi-mi:fbw1a_human(display_long)|uniprotkb:BTRC(gene name)|psi-mi:BTRC(display_short)|uniprotkb:BTRCP(gene name synonym)|uniprotkb:FBW1A(gene name synonym)|uniprotkb:FBXW1A(gene name synonym)|uniprotkb:F-box and WD repeats protein beta-TrCP(gene name synonym)|uniprotkb:E3RSIkappaB(gene name synonym)|uniprotkb:pIkappaBalpha-E3 receptor subunit(gene name synonym)|uniprotkb:Epididymis tissue protein Li 2a(gene name synonym) psi-mi:fbw1b_human(display_long)|uniprotkb:KIAA0696(gene name synonym)|uniprotkb:FBXW11(gene name)|psi-mi:FBXW11(display_short)|uniprotkb:BTRCP2(gene name synonym)|uniprotkb:FBW1B(gene name synonym)|uniprotkb:FBXW1B(gene name synonym)|uniprotkb:F-box/WD repeat-containing protein 1B(gene name synonym)|uniprotkb:F-box and WD repeats protein beta-TrCP2(gene name synonym)|uniprotkb:Homologous to Slimb protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514141|imex:IM-12079-89 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003930.1|refseq:NP_378663.1|ensembl:ENSG00000166167(gene)|ensembl:ENST00000370187(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016874"(ligase activity)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031648"(protein destabilization)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042753"(positive regulation of circadian rhythm)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045309"(protein phosphorylated amino acid binding)|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:1990757"(ubiquitin ligase activator activity)|interpro:IPR001680(WD40 repeat)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|interpro:IPR021977|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|interpro:IPR036047|interpro:IPR036322|mint:Q9Y297|rcsb pdb:1P22|rcsb pdb:2P64|rcsb pdb:6M90|rcsb pdb:6M91|rcsb pdb:6M92|rcsb pdb:6M93|rcsb pdb:6M94|go:"GO:0046983"(protein dimerization activity)|rcsb pdb:6TTU|reactome:R-HSA-1169091|reactome:R-HSA-1170546|go:"GO:0048511"(rhythmic process)|reactome:R-HSA-174113|reactome:R-HSA-180534|reactome:R-HSA-195253|reactome:R-HSA-202424|go:"GO:0051726"(regulation of cell cycle)|reactome:R-HSA-2565942|reactome:R-HSA-2871837|reactome:R-HSA-3769402|reactome:R-HSA-400253|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5676590|reactome:R-HSA-5684264|reactome:R-HSA-8951664|reactome:R-HSA-9020702|reactome:R-HSA-983168|dip:DIP-31607N refseq:NP_036432.2|refseq:NP_387448.2|refseq:NP_387449.2|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007097"(nuclear migration)|go:"GO:0007281"(germ cell development)|go:"GO:0008090"(retrograde axonal transport)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031023"(microtubule organizing center organization)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031648"(protein destabilization)|go:"GO:0042753"(positive regulation of circadian rhythm)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0005635"(nuclear envelope)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0070840"(dynein complex binding)|go:"GO:1904115"(axon cytoplasm)|go:"GO:2000574"(obsolete regulation of microtubule motor activity)|interpro:IPR001680(WD40 repeat)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR021977|interpro:IPR036047|interpro:IPR036322|mint:Q9UKB1|rcsb pdb:6WNX|reactome:R-HSA-1169091|reactome:R-HSA-202424|reactome:R-HSA-2565942|reactome:R-HSA-2871837|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5676590|reactome:R-HSA-5684264|reactome:R-HSA-8951664|reactome:R-HSA-983168|go:"GO:0048511"(rhythmic process)|ensembl:ENSG00000072803(gene)|ensembl:ENST00000265094(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000776"(kinetochore)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|dip:DIP-27593N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/10/11 rogid:9/bXDY6YvJWvP6iMSgOPT9CNGAE9606 rogid:8wLc2Pt+mLfRsNwXOnjho+1A0u09606 intact-crc:C88D00E873055E9C|rigid:zQdZpbQC3mwJxWVbAmO1KYmI+1k false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y297 uniprotkb:P48594 intact:EBI-307461|uniprotkb:Q9Y213|uniprotkb:B5MD49|uniprotkb:Q5W142|ensembl:ENSP00000359206|uniprotkb:Q5W141 intact:EBI-1055490|uniprotkb:A8K847|ensembl:ENSP00000343445 psi-mi:fbw1a_human(display_long)|uniprotkb:BTRC(gene name)|psi-mi:BTRC(display_short)|uniprotkb:BTRCP(gene name synonym)|uniprotkb:FBW1A(gene name synonym)|uniprotkb:FBXW1A(gene name synonym)|uniprotkb:F-box and WD repeats protein beta-TrCP(gene name synonym)|uniprotkb:E3RSIkappaB(gene name synonym)|uniprotkb:pIkappaBalpha-E3 receptor subunit(gene name synonym)|uniprotkb:Epididymis tissue protein Li 2a(gene name synonym) psi-mi:spb4_human(display_long)|uniprotkb:Squamous cell carcinoma antigen 2(gene name synonym)|uniprotkb:Leupin(gene name synonym)|uniprotkb:SERPINB4(gene name)|psi-mi:SERPINB4(display_short)|uniprotkb:SCCA2(gene name synonym)|uniprotkb:PI11(gene name synonym)|uniprotkb:Peptidase inhibitor 11(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514141|imex:IM-12079-89 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003930.1|refseq:NP_378663.1|ensembl:ENSG00000166167(gene)|ensembl:ENST00000370187(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016874"(ligase activity)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031648"(protein destabilization)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042753"(positive regulation of circadian rhythm)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045309"(protein phosphorylated amino acid binding)|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:1990757"(ubiquitin ligase activator activity)|interpro:IPR001680(WD40 repeat)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|interpro:IPR021977|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|interpro:IPR036047|interpro:IPR036322|mint:Q9Y297|rcsb pdb:1P22|rcsb pdb:2P64|rcsb pdb:6M90|rcsb pdb:6M91|rcsb pdb:6M92|rcsb pdb:6M93|rcsb pdb:6M94|go:"GO:0046983"(protein dimerization activity)|rcsb pdb:6TTU|reactome:R-HSA-1169091|reactome:R-HSA-1170546|go:"GO:0048511"(rhythmic process)|reactome:R-HSA-174113|reactome:R-HSA-180534|reactome:R-HSA-195253|reactome:R-HSA-202424|go:"GO:0051726"(regulation of cell cycle)|reactome:R-HSA-2565942|reactome:R-HSA-2871837|reactome:R-HSA-3769402|reactome:R-HSA-400253|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5676590|reactome:R-HSA-5684264|reactome:R-HSA-8951664|reactome:R-HSA-9020702|reactome:R-HSA-983168|dip:DIP-31607N refseq:NP_778206.1|refseq:NP_002965.1|refseq:XP_011524440.1|ensembl:ENSG00000206073(gene)|ensembl:ENST00000341074(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0010466"(negative regulation of peptidase activity)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0042270"(protection from natural killer cell mediated cytotoxicity)|interpro:IPR000215(Protease inhibitor I4, serpin)|interpro:IPR023795|interpro:IPR023796|interpro:IPR036186|interpro:IPR042185|mint:P48594|interpro:IPR042178 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/10/11 rogid:9/bXDY6YvJWvP6iMSgOPT9CNGAE9606 rogid:1kO3L409kom3vIvMuAuBuGZhiH89606 intact-crc:C88D00E873055E9C|rigid:zQdZpbQC3mwJxWVbAmO1KYmI+1k false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y297 uniprotkb:Q5XKE5 intact:EBI-307461|uniprotkb:Q9Y213|uniprotkb:B5MD49|uniprotkb:Q5W142|ensembl:ENSP00000359206|uniprotkb:Q5W141 intact:EBI-2514135|ensembl:ENSP00000328358|uniprotkb:Q6P465|uniprotkb:Q7Z793 psi-mi:fbw1a_human(display_long)|uniprotkb:BTRC(gene name)|psi-mi:BTRC(display_short)|uniprotkb:BTRCP(gene name synonym)|uniprotkb:FBW1A(gene name synonym)|uniprotkb:FBXW1A(gene name synonym)|uniprotkb:F-box and WD repeats protein beta-TrCP(gene name synonym)|uniprotkb:E3RSIkappaB(gene name synonym)|uniprotkb:pIkappaBalpha-E3 receptor subunit(gene name synonym)|uniprotkb:Epididymis tissue protein Li 2a(gene name synonym) psi-mi:k2c79_human(display_long)|uniprotkb:KRT79(gene name)|psi-mi:KRT79(display_short)|uniprotkb:K6L(gene name synonym)|uniprotkb:KB38(gene name synonym)|uniprotkb:KRT6L(gene name synonym)|uniprotkb:Cytokeratin-79(gene name synonym)|uniprotkb:Keratin-79(gene name synonym)|uniprotkb:Type-II keratin Kb38(gene name synonym)|uniprotkb:Keratin-6-like(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514141|imex:IM-12079-89 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003930.1|refseq:NP_378663.1|ensembl:ENSG00000166167(gene)|ensembl:ENST00000370187(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016874"(ligase activity)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031648"(protein destabilization)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042753"(positive regulation of circadian rhythm)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045309"(protein phosphorylated amino acid binding)|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:1990757"(ubiquitin ligase activator activity)|interpro:IPR001680(WD40 repeat)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|interpro:IPR021977|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|interpro:IPR036047|interpro:IPR036322|mint:Q9Y297|rcsb pdb:1P22|rcsb pdb:2P64|rcsb pdb:6M90|rcsb pdb:6M91|rcsb pdb:6M92|rcsb pdb:6M93|rcsb pdb:6M94|go:"GO:0046983"(protein dimerization activity)|rcsb pdb:6TTU|reactome:R-HSA-1169091|reactome:R-HSA-1170546|go:"GO:0048511"(rhythmic process)|reactome:R-HSA-174113|reactome:R-HSA-180534|reactome:R-HSA-195253|reactome:R-HSA-202424|go:"GO:0051726"(regulation of cell cycle)|reactome:R-HSA-2565942|reactome:R-HSA-2871837|reactome:R-HSA-3769402|reactome:R-HSA-400253|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5676590|reactome:R-HSA-5684264|reactome:R-HSA-8951664|reactome:R-HSA-9020702|reactome:R-HSA-983168|dip:DIP-31607N ensembl:ENSG00000185640(gene)|ensembl:ENST00000330553(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0019899"(enzyme binding)|go:"GO:0045095"(keratin filament)|go:"GO:0070062"(extracellular exosome)|interpro:IPR003054(Type II keratin)|interpro:IPR018039|interpro:IPR032444|interpro:IPR039008|mint:Q5XKE5|reactome:R-HSA-6805567|reactome:R-HSA-6809371|refseq:NP_787028.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/10/11 rogid:9/bXDY6YvJWvP6iMSgOPT9CNGAE9606 rogid:6Y6bUekPM7/Xr6UAgHP05OkWzuQ9606 intact-crc:C88D00E873055E9C|rigid:zQdZpbQC3mwJxWVbAmO1KYmI+1k false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y297 uniprotkb:Q96CW5 intact:EBI-307461|uniprotkb:Q9Y213|uniprotkb:B5MD49|uniprotkb:Q5W142|ensembl:ENSP00000359206|uniprotkb:Q5W141 intact:EBI-1046278|ensembl:ENSP00000261965|uniprotkb:O43631|uniprotkb:O60852|uniprotkb:O60853|uniprotkb:Q7Z4K1|uniprotkb:Q96I79|uniprotkb:Q5T8L2 psi-mi:fbw1a_human(display_long)|uniprotkb:BTRC(gene name)|psi-mi:BTRC(display_short)|uniprotkb:BTRCP(gene name synonym)|uniprotkb:FBW1A(gene name synonym)|uniprotkb:FBXW1A(gene name synonym)|uniprotkb:F-box and WD repeats protein beta-TrCP(gene name synonym)|uniprotkb:E3RSIkappaB(gene name synonym)|uniprotkb:pIkappaBalpha-E3 receptor subunit(gene name synonym)|uniprotkb:Epididymis tissue protein Li 2a(gene name synonym) psi-mi:gcp3_human(display_long)|uniprotkb:Spindle pole body protein Spc98 homolog(gene name synonym)|uniprotkb:TUBGCP3(gene name)|psi-mi:TUBGCP3(display_short)|uniprotkb:GCP3(gene name synonym)|uniprotkb:Gamma-ring complex protein 104 kDa(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514141|imex:IM-12079-89 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003930.1|refseq:NP_378663.1|ensembl:ENSG00000166167(gene)|ensembl:ENST00000370187(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016874"(ligase activity)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031648"(protein destabilization)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042753"(positive regulation of circadian rhythm)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045309"(protein phosphorylated amino acid binding)|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:1990757"(ubiquitin ligase activator activity)|interpro:IPR001680(WD40 repeat)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|interpro:IPR021977|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|interpro:IPR036047|interpro:IPR036322|mint:Q9Y297|rcsb pdb:1P22|rcsb pdb:2P64|rcsb pdb:6M90|rcsb pdb:6M91|rcsb pdb:6M92|rcsb pdb:6M93|rcsb pdb:6M94|go:"GO:0046983"(protein dimerization activity)|rcsb pdb:6TTU|reactome:R-HSA-1169091|reactome:R-HSA-1170546|go:"GO:0048511"(rhythmic process)|reactome:R-HSA-174113|reactome:R-HSA-180534|reactome:R-HSA-195253|reactome:R-HSA-202424|go:"GO:0051726"(regulation of cell cycle)|reactome:R-HSA-2565942|reactome:R-HSA-2871837|reactome:R-HSA-3769402|reactome:R-HSA-400253|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5676590|reactome:R-HSA-5684264|reactome:R-HSA-8951664|reactome:R-HSA-9020702|reactome:R-HSA-983168|dip:DIP-31607N go:"GO:0005198"(structural molecule activity)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005819"(spindle)|go:"GO:0005827"(polar microtubule)|go:"GO:0005829"(cytosol)|go:"GO:0007020"(microtubule nucleation)|go:"GO:0007338"(single fertilization)|go:"GO:0008275"(gamma-tubulin small complex)|go:"GO:0016020"(membrane)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0051225"(spindle assembly)|go:"GO:0051321"(meiotic cell cycle)|interpro:IPR007259(Spc97/Spc98)|interpro:IPR040457|interpro:IPR041470|mint:Q96CW5|rcsb pdb:6V6B|go:"GO:0000930"(gamma-tubulin complex)|rcsb pdb:6V6S|rcsb pdb:6X0U|rcsb pdb:7AS4|reactome:R-HSA-380270|reactome:R-HSA-380320|ensembl:ENSG00000126216(gene)|ensembl:ENST00000261965(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000923"(equatorial microtubule organizing center)|refseq:NP_006313.1|refseq:NP_001273207.1|refseq:NP_001273208.1|refseq:NP_001273206.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/10/11 rogid:9/bXDY6YvJWvP6iMSgOPT9CNGAE9606 rogid:xt+Ngo2s/4djh2PnyMEaxgDyLrs9606 intact-crc:C88D00E873055E9C|rigid:zQdZpbQC3mwJxWVbAmO1KYmI+1k false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y297 uniprotkb:P30304 intact:EBI-307461|uniprotkb:Q9Y213|uniprotkb:B5MD49|uniprotkb:Q5W142|ensembl:ENSP00000359206|uniprotkb:Q5W141 intact:EBI-747671|uniprotkb:Q8IZH5|uniprotkb:Q96IL3|uniprotkb:Q9H2F2|ensembl:ENSP00000303706 psi-mi:fbw1a_human(display_long)|uniprotkb:BTRC(gene name)|psi-mi:BTRC(display_short)|uniprotkb:BTRCP(gene name synonym)|uniprotkb:FBW1A(gene name synonym)|uniprotkb:FBXW1A(gene name synonym)|uniprotkb:F-box and WD repeats protein beta-TrCP(gene name synonym)|uniprotkb:E3RSIkappaB(gene name synonym)|uniprotkb:pIkappaBalpha-E3 receptor subunit(gene name synonym)|uniprotkb:Epididymis tissue protein Li 2a(gene name synonym) psi-mi:mpip1_human(display_long)|uniprotkb:Dual specificity phosphatase Cdc25A(gene name synonym)|uniprotkb:CDC25A(gene name)|psi-mi:CDC25A(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514141|imex:IM-12079-89 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003930.1|refseq:NP_378663.1|ensembl:ENSG00000166167(gene)|ensembl:ENST00000370187(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016874"(ligase activity)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031648"(protein destabilization)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042753"(positive regulation of circadian rhythm)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045309"(protein phosphorylated amino acid binding)|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:1990757"(ubiquitin ligase activator activity)|interpro:IPR001680(WD40 repeat)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|interpro:IPR021977|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|interpro:IPR036047|interpro:IPR036322|mint:Q9Y297|rcsb pdb:1P22|rcsb pdb:2P64|rcsb pdb:6M90|rcsb pdb:6M91|rcsb pdb:6M92|rcsb pdb:6M93|rcsb pdb:6M94|go:"GO:0046983"(protein dimerization activity)|rcsb pdb:6TTU|reactome:R-HSA-1169091|reactome:R-HSA-1170546|go:"GO:0048511"(rhythmic process)|reactome:R-HSA-174113|reactome:R-HSA-180534|reactome:R-HSA-195253|reactome:R-HSA-202424|go:"GO:0051726"(regulation of cell cycle)|reactome:R-HSA-2565942|reactome:R-HSA-2871837|reactome:R-HSA-3769402|reactome:R-HSA-400253|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5676590|reactome:R-HSA-5684264|reactome:R-HSA-8951664|reactome:R-HSA-9020702|reactome:R-HSA-983168|dip:DIP-31607N refseq:NP_001780.2|refseq:NP_963861.1|refseq:XP_011532618.1|dip:DIP-166N|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009314"(response to radiation)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0019901"(protein kinase binding)|go:"GO:0034644"(cellular response to UV)|go:"GO:0051087"(chaperone binding)|go:"GO:0051301"(cell division)|go:"GO:0110032"(positive regulation of G2/MI transition of meiotic cell cycle)|interpro:IPR000751(M-phase inducer phosphatase)|interpro:IPR001763(Rhodanese-like)|interpro:IPR036873|mint:P30304|rcsb pdb:1C25|reactome:R-HSA-1362277|reactome:R-HSA-156711|reactome:R-HSA-176187|go:"GO:0004725"(protein tyrosine phosphatase activity)|reactome:R-HSA-5689880|reactome:R-HSA-69273|reactome:R-HSA-69601|reactome:R-HSA-69656|reactome:R-HSA-8862803|reactome:R-HSA-69202|ensembl:ENSG00000164045(gene)|ensembl:ENST00000302506(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0004721"(phosphoprotein phosphatase activity) psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/10/11 rogid:9/bXDY6YvJWvP6iMSgOPT9CNGAE9606 rogid:CgQErDZyEXEPS4+zxb2vFhzYD4c9606 intact-crc:C88D00E873055E9C|rigid:zQdZpbQC3mwJxWVbAmO1KYmI+1k false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y297 uniprotkb:P31629 intact:EBI-307461|uniprotkb:Q9Y213|uniprotkb:B5MD49|uniprotkb:Q5W142|ensembl:ENSP00000359206|uniprotkb:Q5W141 intact:EBI-2514157|ensembl:ENSP00000012134|ensembl:ENSP00000356575|ensembl:ENSP00000356576|uniprotkb:Q02646|uniprotkb:Q9NS05|uniprotkb:Q5THT5 psi-mi:fbw1a_human(display_long)|uniprotkb:BTRC(gene name)|psi-mi:BTRC(display_short)|uniprotkb:BTRCP(gene name synonym)|uniprotkb:FBW1A(gene name synonym)|uniprotkb:FBXW1A(gene name synonym)|uniprotkb:F-box and WD repeats protein beta-TrCP(gene name synonym)|uniprotkb:E3RSIkappaB(gene name synonym)|uniprotkb:pIkappaBalpha-E3 receptor subunit(gene name synonym)|uniprotkb:Epididymis tissue protein Li 2a(gene name synonym) psi-mi:zep2_human(display_long)|uniprotkb:HIVEP2(gene name)|psi-mi:HIVEP2(display_short)|uniprotkb:Human immunodeficiency virus type I enhancer-binding protein 2(gene name synonym)|uniprotkb:MHC-binding protein 2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514141|imex:IM-12079-89 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003930.1|refseq:NP_378663.1|ensembl:ENSG00000166167(gene)|ensembl:ENST00000370187(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016874"(ligase activity)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031648"(protein destabilization)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042753"(positive regulation of circadian rhythm)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045309"(protein phosphorylated amino acid binding)|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:1990757"(ubiquitin ligase activator activity)|interpro:IPR001680(WD40 repeat)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|interpro:IPR021977|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|interpro:IPR036047|interpro:IPR036322|mint:Q9Y297|rcsb pdb:1P22|rcsb pdb:2P64|rcsb pdb:6M90|rcsb pdb:6M91|rcsb pdb:6M92|rcsb pdb:6M93|rcsb pdb:6M94|go:"GO:0046983"(protein dimerization activity)|rcsb pdb:6TTU|reactome:R-HSA-1169091|reactome:R-HSA-1170546|go:"GO:0048511"(rhythmic process)|reactome:R-HSA-174113|reactome:R-HSA-180534|reactome:R-HSA-195253|reactome:R-HSA-202424|go:"GO:0051726"(regulation of cell cycle)|reactome:R-HSA-2565942|reactome:R-HSA-2871837|reactome:R-HSA-3769402|reactome:R-HSA-400253|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5676590|reactome:R-HSA-5684264|reactome:R-HSA-8951664|reactome:R-HSA-9020702|reactome:R-HSA-983168|dip:DIP-31607N ensembl:ENSG00000010818(gene)|ensembl:ENST00000012134(transcript)|ensembl:ENST00000367603(transcript)|ensembl:ENST00000367604(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|refseq:XP_016866294.1|refseq:NP_006725.3 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/10/11 rogid:9/bXDY6YvJWvP6iMSgOPT9CNGAE9606 rogid:/QXXmthWJq/FkgWwIqkVb1z16EU9606 intact-crc:C88D00E873055E9C|rigid:zQdZpbQC3mwJxWVbAmO1KYmI+1k false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9Y297 uniprotkb:Q96D09 intact:EBI-307461|uniprotkb:Q9Y213|uniprotkb:B5MD49|uniprotkb:Q5W142|ensembl:ENSP00000359206|uniprotkb:Q5W141 intact:EBI-473189|ensembl:ENSP00000339057|ensembl:ENSP00000437394|ensembl:ENSP00000437872|ensembl:ENSP00000507692|ensembl:ENSP00000508139|uniprotkb:Q8NAB4|uniprotkb:D3DXA0 psi-mi:fbw1a_human(display_long)|uniprotkb:BTRC(gene name)|psi-mi:BTRC(display_short)|uniprotkb:BTRCP(gene name synonym)|uniprotkb:FBW1A(gene name synonym)|uniprotkb:FBXW1A(gene name synonym)|uniprotkb:F-box and WD repeats protein beta-TrCP(gene name synonym)|uniprotkb:E3RSIkappaB(gene name synonym)|uniprotkb:pIkappaBalpha-E3 receptor subunit(gene name synonym)|uniprotkb:Epididymis tissue protein Li 2a(gene name synonym) psi-mi:gasp2_human(display_long)|uniprotkb:GPRASP2(gene name)|psi-mi:GPRASP2(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514141|imex:IM-12079-89 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_003930.1|refseq:NP_378663.1|ensembl:ENSG00000166167(gene)|ensembl:ENST00000370187(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016874"(ligase activity)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031648"(protein destabilization)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042753"(positive regulation of circadian rhythm)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045309"(protein phosphorylated amino acid binding)|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:1990757"(ubiquitin ligase activator activity)|interpro:IPR001680(WD40 repeat)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|interpro:IPR021977|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|interpro:IPR036047|interpro:IPR036322|mint:Q9Y297|rcsb pdb:1P22|rcsb pdb:2P64|rcsb pdb:6M90|rcsb pdb:6M91|rcsb pdb:6M92|rcsb pdb:6M93|rcsb pdb:6M94|go:"GO:0046983"(protein dimerization activity)|rcsb pdb:6TTU|reactome:R-HSA-1169091|reactome:R-HSA-1170546|go:"GO:0048511"(rhythmic process)|reactome:R-HSA-174113|reactome:R-HSA-180534|reactome:R-HSA-195253|reactome:R-HSA-202424|go:"GO:0051726"(regulation of cell cycle)|reactome:R-HSA-2565942|reactome:R-HSA-2871837|reactome:R-HSA-3769402|reactome:R-HSA-400253|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5676590|reactome:R-HSA-5684264|reactome:R-HSA-8951664|reactome:R-HSA-9020702|reactome:R-HSA-983168|dip:DIP-31607N ensembl:ENSG00000158301(gene)|ensembl:ENST00000332262(transcript)|ensembl:ENST00000483720(transcript)|ensembl:ENST00000486814(transcript)|ensembl:ENST00000535209(transcript)|ensembl:ENST00000543253(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0061484"(hematopoietic stem cell homeostasis)|interpro:IPR006911(Protein of unknown function DUF634)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR043374|refseq:NP_001004051.1|refseq:NP_001171803.1|refseq:NP_001171804.1|refseq:NP_001171805.1|refseq:NP_001186747.1|refseq:NP_612446.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/10/11 rogid:9/bXDY6YvJWvP6iMSgOPT9CNGAE9606 rogid:aUbvpCvGto1y4Rqnri7qaKaygQ89606 intact-crc:C88D00E873055E9C|rigid:zQdZpbQC3mwJxWVbAmO1KYmI+1k false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UKB1 uniprotkb:Q13616 intact:EBI-355189|uniprotkb:Q9P2S8|uniprotkb:Q9P2S9|uniprotkb:Q9Y4C6|uniprotkb:B2RC98|ensembl:ENSP00000265094 intact:EBI-359390|uniprotkb:O60719|uniprotkb:Q08AL6|uniprotkb:Q8IYW1|uniprotkb:D3DWG3|ensembl:ENSP00000326804|ensembl:ENSP00000387160|ensembl:ENSP00000473318|ensembl:ENSP00000499255|ensembl:ENSP00000499277|ensembl:ENSP00000499398 psi-mi:fbw1b_human(display_long)|uniprotkb:KIAA0696(gene name synonym)|uniprotkb:FBXW11(gene name)|psi-mi:FBXW11(display_short)|uniprotkb:BTRCP2(gene name synonym)|uniprotkb:FBW1B(gene name synonym)|uniprotkb:FBXW1B(gene name synonym)|uniprotkb:F-box/WD repeat-containing protein 1B(gene name synonym)|uniprotkb:F-box and WD repeats protein beta-TrCP2(gene name synonym)|uniprotkb:Homologous to Slimb protein(gene name synonym) psi-mi:cul1_human(display_long)|uniprotkb:CUL1(gene name)|psi-mi:CUL1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514231|imex:IM-12079-39 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_036432.2|refseq:NP_387448.2|refseq:NP_387449.2|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007097"(nuclear migration)|go:"GO:0007281"(germ cell development)|go:"GO:0008090"(retrograde axonal transport)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031023"(microtubule organizing center organization)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031648"(protein destabilization)|go:"GO:0042753"(positive regulation of circadian rhythm)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0005635"(nuclear envelope)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0070840"(dynein complex binding)|go:"GO:1904115"(axon cytoplasm)|go:"GO:2000574"(obsolete regulation of microtubule motor activity)|interpro:IPR001680(WD40 repeat)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR021977|interpro:IPR036047|interpro:IPR036322|mint:Q9UKB1|rcsb pdb:6WNX|reactome:R-HSA-1169091|reactome:R-HSA-202424|reactome:R-HSA-2565942|reactome:R-HSA-2871837|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5676590|reactome:R-HSA-5684264|reactome:R-HSA-8951664|reactome:R-HSA-983168|go:"GO:0048511"(rhythmic process)|ensembl:ENSG00000072803(gene)|ensembl:ENST00000265094(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000776"(kinetochore)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|dip:DIP-27593N refseq:NP_003583.2|rcsb pdb:6WCQ|rcsb pdb:7B5L|rcsb pdb:7B5M|rcsb pdb:7B5N|rcsb pdb:7B5R|rcsb pdb:7B5S|reactome:R-HSA-1169091|reactome:R-HSA-1170546|reactome:R-HSA-174113|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-2122947|reactome:R-HSA-2565942|reactome:R-HSA-2644606|reactome:R-HSA-2644607|reactome:R-HSA-2871837|reactome:R-HSA-2894862|reactome:R-HSA-400253|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5676590|reactome:R-HSA-5684264|reactome:R-HSA-68949|reactome:R-HSA-69231|reactome:R-HSA-8854050|reactome:R-HSA-8939902|reactome:R-HSA-8951664|reactome:R-HSA-9020702|reactome:R-HSA-917937|reactome:R-HSA-9604323|reactome:R-HSA-9708530|reactome:R-HSA-983168|refseq:XP_011514931.1|refseq:XP_011514932.1|refseq:XP_011514933.1|refseq:XP_011514934.1|ensembl:ENSG00000055130(gene)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|ensembl:ENST00000325222(transcript)|ensembl:ENST00000409469(transcript)|ensembl:ENST00000602748(transcript)|ensembl:ENST00000662716(transcript)|ensembl:ENST00000663044(transcript)|ensembl:ENST00000665936(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:1990452"(Parkin-FBXW7-Cul1 ubiquitin ligase complex)|interpro:IPR001373(Cullin, N-terminal region)|interpro:IPR016157(Cullin, conserved site)|interpro:IPR016158(Cullin homology)|interpro:IPR016159(Cullin repeat-like)|interpro:IPR019559|interpro:IPR036317|interpro:IPR036388|interpro:IPR036390|mint:Q13616|rcsb pdb:1LDJ|rcsb pdb:1LDK|rcsb pdb:1U6G|rcsb pdb:3RTR|rcsb pdb:3TDU|rcsb pdb:3TDZ|rcsb pdb:4F52|rcsb pdb:4P5O|rcsb pdb:5V89|rcsb pdb:6TTU|refseq:XP_005250117.1|dip:DIP-17013N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/10/11 rogid:8wLc2Pt+mLfRsNwXOnjho+1A0u09606 rogid:OAZP+ifWW3eEnQKb937ww9s1fMQ9606 intact-crc:BD7BBFF01AA5B338|rigid:+kAPRl8AUDqJghroerwJE+BEE9E false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UKB1 uniprotkb:Q96K76 intact:EBI-355189|uniprotkb:Q9P2S8|uniprotkb:Q9P2S9|uniprotkb:Q9Y4C6|uniprotkb:B2RC98|ensembl:ENSP00000265094 intact:EBI-2514143|ensembl:ENSP00000382382|uniprotkb:Q86Y73|uniprotkb:Q9NWN1|uniprotkb:Q9BWI0|uniprotkb:Q8TEP6|uniprotkb:Q658U0|intact:EBI-11020736|uniprotkb:B3KXF5|uniprotkb:E9PM46 psi-mi:fbw1b_human(display_long)|uniprotkb:KIAA0696(gene name synonym)|uniprotkb:FBXW11(gene name)|psi-mi:FBXW11(display_short)|uniprotkb:BTRCP2(gene name synonym)|uniprotkb:FBW1B(gene name synonym)|uniprotkb:FBXW1B(gene name synonym)|uniprotkb:F-box/WD repeat-containing protein 1B(gene name synonym)|uniprotkb:F-box and WD repeats protein beta-TrCP2(gene name synonym)|uniprotkb:Homologous to Slimb protein(gene name synonym) psi-mi:ubp47_human(display_long)|uniprotkb:USP47(gene name)|psi-mi:USP47(display_short)|uniprotkb:Ubiquitin-specific-processing protease 47(gene name synonym)|uniprotkb:Deubiquitinating enzyme 47(gene name synonym)|uniprotkb:Ubiquitin thioesterase 47(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514231|imex:IM-12079-39 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_036432.2|refseq:NP_387448.2|refseq:NP_387449.2|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007097"(nuclear migration)|go:"GO:0007281"(germ cell development)|go:"GO:0008090"(retrograde axonal transport)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031023"(microtubule organizing center organization)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031648"(protein destabilization)|go:"GO:0042753"(positive regulation of circadian rhythm)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0005635"(nuclear envelope)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0070840"(dynein complex binding)|go:"GO:1904115"(axon cytoplasm)|go:"GO:2000574"(obsolete regulation of microtubule motor activity)|interpro:IPR001680(WD40 repeat)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR021977|interpro:IPR036047|interpro:IPR036322|mint:Q9UKB1|rcsb pdb:6WNX|reactome:R-HSA-1169091|reactome:R-HSA-202424|reactome:R-HSA-2565942|reactome:R-HSA-2871837|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5676590|reactome:R-HSA-5684264|reactome:R-HSA-8951664|reactome:R-HSA-983168|go:"GO:0048511"(rhythmic process)|ensembl:ENSG00000072803(gene)|ensembl:ENST00000265094(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000776"(kinetochore)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|dip:DIP-27593N refseq:NP_001269588.1|ensembl:ENSG00000170242(gene)|ensembl:ENST00000399455(transcript)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006284"(base-excision repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010972"(negative regulation of G2/M transition of mitotic cell cycle)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035520"(monoubiquitinated protein deubiquitination)|go:"GO:0042493"|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0071987"(WD40-repeat domain binding)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0101005"(deubiquitinase activity)|go:"GO:1902230"(negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR029071|interpro:IPR038765|mint:Q96K76|reactome:R-HSA-5689880|refseq:NP_001317137.1|refseq:NP_060414.3|dip:DIP-53629N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/10/11 rogid:8wLc2Pt+mLfRsNwXOnjho+1A0u09606 rogid:XPhYwHpj4bDPhA/uMESoVswI6Jo9606 intact-crc:BD7BBFF01AA5B338|rigid:+kAPRl8AUDqJghroerwJE+BEE9E false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UKB1 uniprotkb:P15822 intact:EBI-355189|uniprotkb:Q9P2S8|uniprotkb:Q9P2S9|uniprotkb:Q9Y4C6|uniprotkb:B2RC98|ensembl:ENSP00000265094 intact:EBI-722264|uniprotkb:Q14122|uniprotkb:Q5VW60|uniprotkb:B2RTU3|uniprotkb:Q5MPB1|ensembl:ENSP00000368698 psi-mi:fbw1b_human(display_long)|uniprotkb:KIAA0696(gene name synonym)|uniprotkb:FBXW11(gene name)|psi-mi:FBXW11(display_short)|uniprotkb:BTRCP2(gene name synonym)|uniprotkb:FBW1B(gene name synonym)|uniprotkb:FBXW1B(gene name synonym)|uniprotkb:F-box/WD repeat-containing protein 1B(gene name synonym)|uniprotkb:F-box and WD repeats protein beta-TrCP2(gene name synonym)|uniprotkb:Homologous to Slimb protein(gene name synonym) psi-mi:zep1_human(display_long)|uniprotkb:Human immunodeficiency virus type I enhancer-binding protein 1(gene name synonym)|uniprotkb:Major histocompatibility complex-binding protein 1(gene name synonym)|uniprotkb:Positive regulatory domain II-binding factor 1(gene name synonym)|uniprotkb:HIVEP1(gene name)|psi-mi:HIVEP1(display_short)|uniprotkb:ZNF40(gene name synonym)|uniprotkb:Gate keeper of apoptosis-activating protein(gene name synonym)|uniprotkb:Cirhin interaction protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514231|imex:IM-12079-39 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_036432.2|refseq:NP_387448.2|refseq:NP_387449.2|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007097"(nuclear migration)|go:"GO:0007281"(germ cell development)|go:"GO:0008090"(retrograde axonal transport)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031023"(microtubule organizing center organization)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031648"(protein destabilization)|go:"GO:0042753"(positive regulation of circadian rhythm)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0005635"(nuclear envelope)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0070840"(dynein complex binding)|go:"GO:1904115"(axon cytoplasm)|go:"GO:2000574"(obsolete regulation of microtubule motor activity)|interpro:IPR001680(WD40 repeat)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR021977|interpro:IPR036047|interpro:IPR036322|mint:Q9UKB1|rcsb pdb:6WNX|reactome:R-HSA-1169091|reactome:R-HSA-202424|reactome:R-HSA-2565942|reactome:R-HSA-2871837|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5676590|reactome:R-HSA-5684264|reactome:R-HSA-8951664|reactome:R-HSA-983168|go:"GO:0048511"(rhythmic process)|ensembl:ENSG00000072803(gene)|ensembl:ENST00000265094(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000776"(kinetochore)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|dip:DIP-27593N refseq:NP_002105.3|ensembl:ENSG00000095951(gene)|ensembl:ENST00000379388(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0016604"(nuclear body)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR034729|interpro:IPR036236|mint:P15822|rcsb pdb:1BBO|rcsb pdb:3ZNF|rcsb pdb:4ZNF psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/10/11 rogid:8wLc2Pt+mLfRsNwXOnjho+1A0u09606 rogid:rugwzqsTO0X8mJ5Zy3msTqc6dr09606 intact-crc:BD7BBFF01AA5B338|rigid:+kAPRl8AUDqJghroerwJE+BEE9E false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UKB1 uniprotkb:Q86T82 intact:EBI-355189|uniprotkb:Q9P2S8|uniprotkb:Q9P2S9|uniprotkb:Q9Y4C6|uniprotkb:B2RC98|ensembl:ENSP00000265094 intact:EBI-2513613|intact:EBI-2514223|uniprotkb:B7ZM38|uniprotkb:B7ZM41|uniprotkb:Q7Z3A5|uniprotkb:E9PHL3|uniprotkb:Q2KHT2|ensembl:ENSP00000258399|ensembl:ENSP00000393662|ensembl:ENSP00000396585|uniprotkb:Q9HCH8|uniprotkb:A2RUQ8|uniprotkb:Q53S10 psi-mi:fbw1b_human(display_long)|uniprotkb:KIAA0696(gene name synonym)|uniprotkb:FBXW11(gene name)|psi-mi:FBXW11(display_short)|uniprotkb:BTRCP2(gene name synonym)|uniprotkb:FBW1B(gene name synonym)|uniprotkb:FBXW1B(gene name synonym)|uniprotkb:F-box/WD repeat-containing protein 1B(gene name synonym)|uniprotkb:F-box and WD repeats protein beta-TrCP2(gene name synonym)|uniprotkb:Homologous to Slimb protein(gene name synonym) psi-mi:ubp37_human(display_long)|uniprotkb:USP37(gene name)|psi-mi:USP37(display_short)|uniprotkb:KIAA1594(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 37(gene name synonym)|uniprotkb:Deubiquitinating enzyme 37(gene name synonym)|uniprotkb:Ubiquitin thioesterase 37(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514231|imex:IM-12079-39 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_036432.2|refseq:NP_387448.2|refseq:NP_387449.2|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007097"(nuclear migration)|go:"GO:0007281"(germ cell development)|go:"GO:0008090"(retrograde axonal transport)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031023"(microtubule organizing center organization)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031648"(protein destabilization)|go:"GO:0042753"(positive regulation of circadian rhythm)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0005635"(nuclear envelope)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0070840"(dynein complex binding)|go:"GO:1904115"(axon cytoplasm)|go:"GO:2000574"(obsolete regulation of microtubule motor activity)|interpro:IPR001680(WD40 repeat)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR021977|interpro:IPR036047|interpro:IPR036322|mint:Q9UKB1|rcsb pdb:6WNX|reactome:R-HSA-1169091|reactome:R-HSA-202424|reactome:R-HSA-2565942|reactome:R-HSA-2871837|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5676590|reactome:R-HSA-5684264|reactome:R-HSA-8951664|reactome:R-HSA-983168|go:"GO:0048511"(rhythmic process)|ensembl:ENSG00000072803(gene)|ensembl:ENST00000265094(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000776"(kinetochore)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|dip:DIP-27593N go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019901"(protein kinase binding)|go:"GO:0035871"(protein K11-linked deubiquitination)|go:"GO:0051301"(cell division)|go:"GO:0071108"(protein K48-linked deubiquitination)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR018200|interpro:IPR028889|interpro:IPR032069|interpro:IPR038093|go:"GO:0005829"(cytosol)|interpro:IPR038765|rcsb pdb:3U12|reactome:R-HSA-5689880|ensembl:ENSG00000135913(gene)|ensembl:ENST00000258399(transcript)|ensembl:ENST00000418019(transcript)|ensembl:ENST00000454775(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|refseq:XP_011509840.1|refseq:NP_065986.2|refseq:XP_005246777.1|refseq:XP_005246778.1|refseq:XP_005246779.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/10/11 rogid:8wLc2Pt+mLfRsNwXOnjho+1A0u09606 rogid:2DOjCrilHkv+l0r0zBQ1td2p+qc9606 intact-crc:BD7BBFF01AA5B338|rigid:+kAPRl8AUDqJghroerwJE+BEE9E false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UKB1 uniprotkb:O76031 intact:EBI-355189|uniprotkb:Q9P2S8|uniprotkb:Q9P2S9|uniprotkb:Q9Y4C6|uniprotkb:B2RC98|ensembl:ENSP00000265094 intact:EBI-1052667|uniprotkb:A1L428|uniprotkb:A8K8F1|uniprotkb:Q9H4D9|uniprotkb:B9EGI8|ensembl:ENSP00000300107 psi-mi:fbw1b_human(display_long)|uniprotkb:KIAA0696(gene name synonym)|uniprotkb:FBXW11(gene name)|psi-mi:FBXW11(display_short)|uniprotkb:BTRCP2(gene name synonym)|uniprotkb:FBW1B(gene name synonym)|uniprotkb:FBXW1B(gene name synonym)|uniprotkb:F-box/WD repeat-containing protein 1B(gene name synonym)|uniprotkb:F-box and WD repeats protein beta-TrCP2(gene name synonym)|uniprotkb:Homologous to Slimb protein(gene name synonym) psi-mi:clpx_human(display_long)|uniprotkb:CLPX(gene name)|psi-mi:CLPX(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514231|imex:IM-12079-39 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_036432.2|refseq:NP_387448.2|refseq:NP_387449.2|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007097"(nuclear migration)|go:"GO:0007281"(germ cell development)|go:"GO:0008090"(retrograde axonal transport)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031023"(microtubule organizing center organization)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031648"(protein destabilization)|go:"GO:0042753"(positive regulation of circadian rhythm)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0005635"(nuclear envelope)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0070840"(dynein complex binding)|go:"GO:1904115"(axon cytoplasm)|go:"GO:2000574"(obsolete regulation of microtubule motor activity)|interpro:IPR001680(WD40 repeat)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR021977|interpro:IPR036047|interpro:IPR036322|mint:Q9UKB1|rcsb pdb:6WNX|reactome:R-HSA-1169091|reactome:R-HSA-202424|reactome:R-HSA-2565942|reactome:R-HSA-2871837|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5676590|reactome:R-HSA-5684264|reactome:R-HSA-8951664|reactome:R-HSA-983168|go:"GO:0048511"(rhythmic process)|ensembl:ENSG00000072803(gene)|ensembl:ENST00000265094(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000776"(kinetochore)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|dip:DIP-27593N refseq:NP_006651.2|ensembl:ENSG00000166855(gene)|ensembl:ENST00000300107(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006508"(proteolysis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009368"(endopeptidase Clp complex)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0030163"(protein catabolic process)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR004487(ClpX, ATPase regulatory subunit)|interpro:IPR010603(Zinc finger, C4-type)|interpro:IPR019489|interpro:IPR027417|go:"GO:0009841"(mitochondrial endopeptidase Clp complex)|mint:O76031|dip:DIP-50293N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/10/11 rogid:8wLc2Pt+mLfRsNwXOnjho+1A0u09606 rogid:+SOis7raPEZqqeel6Y6dOWJcLj49606 intact-crc:BD7BBFF01AA5B338|rigid:+kAPRl8AUDqJghroerwJE+BEE9E false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UKB1 uniprotkb:Q9Y266 intact:EBI-355189|uniprotkb:Q9P2S8|uniprotkb:Q9P2S9|uniprotkb:Q9Y4C6|uniprotkb:B2RC98|ensembl:ENSP00000265094 intact:EBI-357298|ensembl:ENSP00000319664|uniprotkb:Q5QP31|uniprotkb:Q5QP35|uniprotkb:Q9H0N2|uniprotkb:Q9Y2B6|intact:EBI-2555945 psi-mi:fbw1b_human(display_long)|uniprotkb:KIAA0696(gene name synonym)|uniprotkb:FBXW11(gene name)|psi-mi:FBXW11(display_short)|uniprotkb:BTRCP2(gene name synonym)|uniprotkb:FBW1B(gene name synonym)|uniprotkb:FBXW1B(gene name synonym)|uniprotkb:F-box/WD repeat-containing protein 1B(gene name synonym)|uniprotkb:F-box and WD repeats protein beta-TrCP2(gene name synonym)|uniprotkb:Homologous to Slimb protein(gene name synonym) psi-mi:nudc_human(display_long)|uniprotkb:NUDC(gene name)|psi-mi:NUDC(display_short)|uniprotkb:Nuclear distribution protein C homolog(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514231|imex:IM-12079-39 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_036432.2|refseq:NP_387448.2|refseq:NP_387449.2|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007097"(nuclear migration)|go:"GO:0007281"(germ cell development)|go:"GO:0008090"(retrograde axonal transport)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031023"(microtubule organizing center organization)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031648"(protein destabilization)|go:"GO:0042753"(positive regulation of circadian rhythm)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0005635"(nuclear envelope)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0070840"(dynein complex binding)|go:"GO:1904115"(axon cytoplasm)|go:"GO:2000574"(obsolete regulation of microtubule motor activity)|interpro:IPR001680(WD40 repeat)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR021977|interpro:IPR036047|interpro:IPR036322|mint:Q9UKB1|rcsb pdb:6WNX|reactome:R-HSA-1169091|reactome:R-HSA-202424|reactome:R-HSA-2565942|reactome:R-HSA-2871837|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5676590|reactome:R-HSA-5684264|reactome:R-HSA-8951664|reactome:R-HSA-983168|go:"GO:0048511"(rhythmic process)|ensembl:ENSG00000072803(gene)|ensembl:ENST00000265094(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000776"(kinetochore)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|dip:DIP-27593N ensembl:ENSG00000090273(gene)|ensembl:ENST00000321265(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0006457"(protein folding)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0030496"(midbody)|go:"GO:0045296"(cadherin binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051301"(cell division)|go:"GO:0072686"(mitotic spindle)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR032572|interpro:IPR037898|mint:Q9Y266|rcsb pdb:3QOR|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|go:"GO:0007080"(mitotic metaphase plate congression)|reactome:R-HSA-9696270|refseq:NP_006591.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/10/11 rogid:8wLc2Pt+mLfRsNwXOnjho+1A0u09606 rogid:e1Q+/+VhG73ljCc3+ibG+RZNQUM9606 intact-crc:BD7BBFF01AA5B338|rigid:+kAPRl8AUDqJghroerwJE+BEE9E false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UKB1 uniprotkb:Q9UH99 intact:EBI-355189|uniprotkb:Q9P2S8|uniprotkb:Q9P2S9|uniprotkb:Q9Y4C6|uniprotkb:B2RC98|ensembl:ENSP00000265094 intact:EBI-1044964|uniprotkb:O75156|uniprotkb:Q2NKN8|uniprotkb:Q6B4H1|uniprotkb:Q7Z3E3|uniprotkb:Q2T9F7|ensembl:ENSP00000383992|ensembl:ENSP00000385740|uniprotkb:B0QY62|uniprotkb:Q504T5 psi-mi:fbw1b_human(display_long)|uniprotkb:KIAA0696(gene name synonym)|uniprotkb:FBXW11(gene name)|psi-mi:FBXW11(display_short)|uniprotkb:BTRCP2(gene name synonym)|uniprotkb:FBW1B(gene name synonym)|uniprotkb:FBXW1B(gene name synonym)|uniprotkb:F-box/WD repeat-containing protein 1B(gene name synonym)|uniprotkb:F-box and WD repeats protein beta-TrCP2(gene name synonym)|uniprotkb:Homologous to Slimb protein(gene name synonym) psi-mi:sun2_human(display_long)|uniprotkb:Sad1/unc-84 protein-like 2(gene name synonym)|uniprotkb:Rab5-interacting protein(gene name synonym)|uniprotkb:SUN2(gene name)|psi-mi:SUN2(display_short)|uniprotkb:FRIGG(gene name synonym)|uniprotkb:KIAA0668(gene name synonym)|uniprotkb:RAB5IP(gene name synonym)|uniprotkb:UNC84B(gene name synonym)|uniprotkb:Protein unc-84 homolog B(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514231|imex:IM-12079-39 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_036432.2|refseq:NP_387448.2|refseq:NP_387449.2|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007097"(nuclear migration)|go:"GO:0007281"(germ cell development)|go:"GO:0008090"(retrograde axonal transport)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031023"(microtubule organizing center organization)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031648"(protein destabilization)|go:"GO:0042753"(positive regulation of circadian rhythm)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0005635"(nuclear envelope)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0070840"(dynein complex binding)|go:"GO:1904115"(axon cytoplasm)|go:"GO:2000574"(obsolete regulation of microtubule motor activity)|interpro:IPR001680(WD40 repeat)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR021977|interpro:IPR036047|interpro:IPR036322|mint:Q9UKB1|rcsb pdb:6WNX|reactome:R-HSA-1169091|reactome:R-HSA-202424|reactome:R-HSA-2565942|reactome:R-HSA-2871837|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5676590|reactome:R-HSA-5684264|reactome:R-HSA-8951664|reactome:R-HSA-983168|go:"GO:0048511"(rhythmic process)|ensembl:ENSG00000072803(gene)|ensembl:ENST00000265094(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000776"(kinetochore)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|dip:DIP-27593N refseq:NP_001186508.1|refseq:NP_001186509.1|refseq:NP_056189.1|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0005521"(lamin binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005639"(integral component of nuclear inner membrane)|go:"GO:0006998"(nuclear envelope organization)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007097"(nuclear migration)|go:"GO:0008017"(microtubule binding)|go:"GO:0010008"(endosome membrane)|go:"GO:0021817"(nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031022"(nuclear migration along microfilament)|go:"GO:0031965"(nuclear membrane)|go:"GO:0034993"(meiotic nuclear membrane microtubule tethering complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0051642"(centrosome localization)|go:"GO:0090292"(nuclear matrix anchoring at nuclear membrane)|go:"GO:0140444"(cytoskeleton-nuclear membrane anchor activity)|go:"GO:0000781"(chromosome, telomeric region)|interpro:IPR012919(Sad1/UNC-like, C-terminal)|interpro:IPR030272|interpro:IPR040994|mint:Q9UH99|ensembl:ENSG00000100242(gene)|ensembl:ENST00000405510(transcript)|ensembl:ENST00000406622(transcript)|rcsb pdb:4DXS|rcsb pdb:4DXT|rcsb pdb:4FI9|rcsb pdb:6WMD|rcsb pdb:6WME|rcsb pdb:6WMF|rcsb pdb:6WMG|reactome:R-HSA-1221632|rcsb pdb:4DXR|rcsb pdb:3UNP psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/10/11 rogid:8wLc2Pt+mLfRsNwXOnjho+1A0u09606 rogid:nG0s5eHv6AGh8rcdhTIJ1RdpfbU9606 intact-crc:BD7BBFF01AA5B338|rigid:+kAPRl8AUDqJghroerwJE+BEE9E false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UKB1 uniprotkb:Q96CW5 intact:EBI-355189|uniprotkb:Q9P2S8|uniprotkb:Q9P2S9|uniprotkb:Q9Y4C6|uniprotkb:B2RC98|ensembl:ENSP00000265094 intact:EBI-1046278|ensembl:ENSP00000261965|uniprotkb:O43631|uniprotkb:O60852|uniprotkb:O60853|uniprotkb:Q7Z4K1|uniprotkb:Q96I79|uniprotkb:Q5T8L2 psi-mi:fbw1b_human(display_long)|uniprotkb:KIAA0696(gene name synonym)|uniprotkb:FBXW11(gene name)|psi-mi:FBXW11(display_short)|uniprotkb:BTRCP2(gene name synonym)|uniprotkb:FBW1B(gene name synonym)|uniprotkb:FBXW1B(gene name synonym)|uniprotkb:F-box/WD repeat-containing protein 1B(gene name synonym)|uniprotkb:F-box and WD repeats protein beta-TrCP2(gene name synonym)|uniprotkb:Homologous to Slimb protein(gene name synonym) psi-mi:gcp3_human(display_long)|uniprotkb:Spindle pole body protein Spc98 homolog(gene name synonym)|uniprotkb:TUBGCP3(gene name)|psi-mi:TUBGCP3(display_short)|uniprotkb:GCP3(gene name synonym)|uniprotkb:Gamma-ring complex protein 104 kDa(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514231|imex:IM-12079-39 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_036432.2|refseq:NP_387448.2|refseq:NP_387449.2|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007097"(nuclear migration)|go:"GO:0007281"(germ cell development)|go:"GO:0008090"(retrograde axonal transport)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031023"(microtubule organizing center organization)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031648"(protein destabilization)|go:"GO:0042753"(positive regulation of circadian rhythm)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0005635"(nuclear envelope)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0070840"(dynein complex binding)|go:"GO:1904115"(axon cytoplasm)|go:"GO:2000574"(obsolete regulation of microtubule motor activity)|interpro:IPR001680(WD40 repeat)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR021977|interpro:IPR036047|interpro:IPR036322|mint:Q9UKB1|rcsb pdb:6WNX|reactome:R-HSA-1169091|reactome:R-HSA-202424|reactome:R-HSA-2565942|reactome:R-HSA-2871837|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5676590|reactome:R-HSA-5684264|reactome:R-HSA-8951664|reactome:R-HSA-983168|go:"GO:0048511"(rhythmic process)|ensembl:ENSG00000072803(gene)|ensembl:ENST00000265094(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000776"(kinetochore)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|dip:DIP-27593N go:"GO:0005198"(structural molecule activity)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005819"(spindle)|go:"GO:0005827"(polar microtubule)|go:"GO:0005829"(cytosol)|go:"GO:0007020"(microtubule nucleation)|go:"GO:0007338"(single fertilization)|go:"GO:0008275"(gamma-tubulin small complex)|go:"GO:0016020"(membrane)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0051225"(spindle assembly)|go:"GO:0051321"(meiotic cell cycle)|interpro:IPR007259(Spc97/Spc98)|interpro:IPR040457|interpro:IPR041470|mint:Q96CW5|rcsb pdb:6V6B|go:"GO:0000930"(gamma-tubulin complex)|rcsb pdb:6V6S|rcsb pdb:6X0U|rcsb pdb:7AS4|reactome:R-HSA-380270|reactome:R-HSA-380320|ensembl:ENSG00000126216(gene)|ensembl:ENST00000261965(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000923"(equatorial microtubule organizing center)|refseq:NP_006313.1|refseq:NP_001273207.1|refseq:NP_001273208.1|refseq:NP_001273206.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/10/11 rogid:8wLc2Pt+mLfRsNwXOnjho+1A0u09606 rogid:xt+Ngo2s/4djh2PnyMEaxgDyLrs9606 intact-crc:BD7BBFF01AA5B338|rigid:+kAPRl8AUDqJghroerwJE+BEE9E false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UKB1 uniprotkb:Q9HD67 intact:EBI-355189|uniprotkb:Q9P2S8|uniprotkb:Q9P2S9|uniprotkb:Q9Y4C6|uniprotkb:B2RC98|ensembl:ENSP00000265094 intact:EBI-307061|uniprotkb:O94893|uniprotkb:Q9NYM7|uniprotkb:Q9P110|uniprotkb:Q9P111|uniprotkb:Q9UHF6|ensembl:ENSP00000421280|uniprotkb:A7E2D1|uniprotkb:Q8IVX5 psi-mi:fbw1b_human(display_long)|uniprotkb:KIAA0696(gene name synonym)|uniprotkb:FBXW11(gene name)|psi-mi:FBXW11(display_short)|uniprotkb:BTRCP2(gene name synonym)|uniprotkb:FBW1B(gene name synonym)|uniprotkb:FBXW1B(gene name synonym)|uniprotkb:F-box/WD repeat-containing protein 1B(gene name synonym)|uniprotkb:F-box and WD repeats protein beta-TrCP2(gene name synonym)|uniprotkb:Homologous to Slimb protein(gene name synonym) psi-mi:myo10_human(display_long)|uniprotkb:MYO10(gene name)|psi-mi:MYO10(display_short)|uniprotkb:KIAA0799(gene name synonym)|uniprotkb:Unconventional myosin-10(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514231|imex:IM-12079-39 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_036432.2|refseq:NP_387448.2|refseq:NP_387449.2|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007097"(nuclear migration)|go:"GO:0007281"(germ cell development)|go:"GO:0008090"(retrograde axonal transport)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031023"(microtubule organizing center organization)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031648"(protein destabilization)|go:"GO:0042753"(positive regulation of circadian rhythm)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0005635"(nuclear envelope)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0070840"(dynein complex binding)|go:"GO:1904115"(axon cytoplasm)|go:"GO:2000574"(obsolete regulation of microtubule motor activity)|interpro:IPR001680(WD40 repeat)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR021977|interpro:IPR036047|interpro:IPR036322|mint:Q9UKB1|rcsb pdb:6WNX|reactome:R-HSA-1169091|reactome:R-HSA-202424|reactome:R-HSA-2565942|reactome:R-HSA-2871837|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5676590|reactome:R-HSA-5684264|reactome:R-HSA-8951664|reactome:R-HSA-983168|go:"GO:0048511"(rhythmic process)|ensembl:ENSG00000072803(gene)|ensembl:ENST00000265094(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000776"(kinetochore)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|dip:DIP-27593N ensembl:ENSG00000145555(gene)|ensembl:ENST00000513610(transcript)|go:"GO:0000146"(microfilament motor activity)|go:"GO:0001726"(ruffle)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005524"(ATP binding)|go:"GO:0007165"(signal transduction)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016459"(myosin complex)|go:"GO:0022409"(positive regulation of cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030507"(spectrin binding)|go:"GO:0030705"(cytoskeleton-dependent intracellular transport)|go:"GO:0031527"(filopodium membrane)|go:"GO:0032433"(filopodium tip)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0051015"(actin filament binding)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0060002"(plus-end directed microfilament motor activity)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR000159(Ras-association)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000857(Unconventional myosin/plant kinesin-like protein/non-motor protein conserved region MyTH4)|interpro:IPR001609(Myosin head, motor region)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR019748|interpro:IPR019749|interpro:IPR027417|go:"GO:0005938"(cell cortex)|interpro:IPR031971|interpro:IPR035963|interpro:IPR036124|interpro:IPR036961|interpro:IPR038185|interpro:IPR040640|interpro:IPR041797|mint:Q9HD67|rcsb pdb:2LW9|rcsb pdb:3AU4|rcsb pdb:3AU5|rcsb pdb:3PZD|rcsb pdb:5I0H|rcsb pdb:5I0I|rcsb pdb:5KG8|reactome:R-HSA-2029482|reactome:R-HSA-373752|reactome:R-HSA-9664422|refseq:NP_036466.2|dip:DIP-46151N|refseq:XP_011512348.1|refseq:XP_005248364.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/10/11 rogid:8wLc2Pt+mLfRsNwXOnjho+1A0u09606 rogid:jLJNkmm2IVGyy/edWjHnA97tJdY9606 intact-crc:BD7BBFF01AA5B338|rigid:+kAPRl8AUDqJghroerwJE+BEE9E false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UKB1 uniprotkb:P63208 intact:EBI-355189|uniprotkb:Q9P2S8|uniprotkb:Q9P2S9|uniprotkb:Q9Y4C6|uniprotkb:B2RC98|ensembl:ENSP00000265094 intact:EBI-307486|uniprotkb:P34991|uniprotkb:Q8TAY2|uniprotkb:D3DQ97|uniprotkb:D3DQ98|ensembl:ENSP00000231487|ensembl:ENSP00000429686|ensembl:ENSP00000429961 psi-mi:fbw1b_human(display_long)|uniprotkb:KIAA0696(gene name synonym)|uniprotkb:FBXW11(gene name)|psi-mi:FBXW11(display_short)|uniprotkb:BTRCP2(gene name synonym)|uniprotkb:FBW1B(gene name synonym)|uniprotkb:FBXW1B(gene name synonym)|uniprotkb:F-box/WD repeat-containing protein 1B(gene name synonym)|uniprotkb:F-box and WD repeats protein beta-TrCP2(gene name synonym)|uniprotkb:Homologous to Slimb protein(gene name synonym) psi-mi:skp1_human(display_long)|uniprotkb:SKP1(gene name)|psi-mi:SKP1(display_short)|uniprotkb:EMC19(gene name synonym)|uniprotkb:OCP2(gene name synonym)|uniprotkb:SKP1A(gene name synonym)|uniprotkb:TCEB1L(gene name synonym)|uniprotkb:Cyclin-A/CDK2-associated protein p19(gene name synonym)|uniprotkb:p19skp1(gene name synonym)|uniprotkb:RNA polymerase II elongation factor-like protein(gene name synonym)|uniprotkb:Organ of Corti protein 2(gene name synonym)|uniprotkb:Organ of Corti protein II(gene name synonym)|uniprotkb:SIII(gene name synonym)|uniprotkb:Transcription elongation factor B polypeptide 1-like(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514231|imex:IM-12079-39 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_036432.2|refseq:NP_387448.2|refseq:NP_387449.2|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007097"(nuclear migration)|go:"GO:0007281"(germ cell development)|go:"GO:0008090"(retrograde axonal transport)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031023"(microtubule organizing center organization)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031648"(protein destabilization)|go:"GO:0042753"(positive regulation of circadian rhythm)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0005635"(nuclear envelope)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0070840"(dynein complex binding)|go:"GO:1904115"(axon cytoplasm)|go:"GO:2000574"(obsolete regulation of microtubule motor activity)|interpro:IPR001680(WD40 repeat)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR021977|interpro:IPR036047|interpro:IPR036322|mint:Q9UKB1|rcsb pdb:6WNX|reactome:R-HSA-1169091|reactome:R-HSA-202424|reactome:R-HSA-2565942|reactome:R-HSA-2871837|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5676590|reactome:R-HSA-5684264|reactome:R-HSA-8951664|reactome:R-HSA-983168|go:"GO:0048511"(rhythmic process)|ensembl:ENSG00000072803(gene)|ensembl:ENST00000265094(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000776"(kinetochore)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|dip:DIP-27593N reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5676590|reactome:R-HSA-5684264|reactome:R-HSA-1170546|reactome:R-HSA-174113|reactome:R-HSA-180534|reactome:R-HSA-187577|reactome:R-HSA-68949|reactome:R-HSA-69231|reactome:R-HSA-8854050|reactome:R-HSA-8939902|reactome:R-HSA-8951664|reactome:R-HSA-9020702|reactome:R-HSA-917937|reactome:R-HSA-9604323|reactome:R-HSA-9708530|reactome:R-HSA-983168|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-2122947|reactome:R-HSA-2565942|reactome:R-HSA-2644606|reactome:R-HSA-2644607|reactome:R-HSA-2871837|reactome:R-HSA-2894862|reactome:R-HSA-400253|reactome:R-HSA-5607761|refseq:NP_008861.2|refseq:NP_733779.1|ensembl:ENSG00000113558(gene)|ensembl:ENST00000353411(transcript)|ensembl:ENST00000522855(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|ensembl:ENST00000517625(transcript)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031467"(Cul7-RING ubiquitin ligase complex)|go:"GO:0035518"(histone H2A monoubiquitination)|go:"GO:0051457"(maintenance of protein location in nucleus)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0097602"(cullin family protein binding)|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|go:"GO:1990444"(F-box domain binding)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|interpro:IPR001232(SKP1 component)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR016072(SKP1 component, dimerisation)|interpro:IPR016073(SKP1 component, POZ)|interpro:IPR016897(E3 ubiquitin ligase, SCF complex, Skp subunit)|interpro:IPR036296|mint:P63208|rcsb pdb:1FQV|rcsb pdb:1FS1|rcsb pdb:1FS2|rcsb pdb:1LDK|rcsb pdb:1P22|rcsb pdb:2ASS|rcsb pdb:2AST|rcsb pdb:2E31|rcsb pdb:2E32|rcsb pdb:2OVP|rcsb pdb:2OVQ|rcsb pdb:2OVR|rcsb pdb:3L2O|rcsb pdb:3WSO|rcsb pdb:4I6J|rcsb pdb:5IBK|rcsb pdb:5JH5|rcsb pdb:5K35|rcsb pdb:5V4B|rcsb pdb:5VZT|rcsb pdb:5VZU|rcsb pdb:5XYL|rcsb pdb:6BVA|rcsb pdb:6BYH|rcsb pdb:6C16|rcsb pdb:6M90|rcsb pdb:6M91|rcsb pdb:6M92|rcsb pdb:6M93|rcsb pdb:6M94|rcsb pdb:6O60|rcsb pdb:6TTU|rcsb pdb:6VCD|rcsb pdb:6W66|rcsb pdb:6WCQ|rcsb pdb:6WNX|rcsb pdb:7B5L|rcsb pdb:7B5M|rcsb pdb:7B5R|reactome:R-HSA-1169091|dip:DIP-31606N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/10/11 rogid:8wLc2Pt+mLfRsNwXOnjho+1A0u09606 rogid:0U28UYW/heL+7UJO5f3h8Wq+Ud09606 intact-crc:BD7BBFF01AA5B338|rigid:+kAPRl8AUDqJghroerwJE+BEE9E false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UKB1 uniprotkb:P30305 intact:EBI-355189|uniprotkb:Q9P2S8|uniprotkb:Q9P2S9|uniprotkb:Q9Y4C6|uniprotkb:B2RC98|ensembl:ENSP00000265094 intact:EBI-1051746|uniprotkb:O43551|uniprotkb:Q13971|uniprotkb:Q5JX77|uniprotkb:Q6RSS1|uniprotkb:Q9BRA6|uniprotkb:D3DVY1|uniprotkb:D3DVY2|uniprotkb:D3DVY3|uniprotkb:D3DVY4|ensembl:ENSP00000245960 psi-mi:fbw1b_human(display_long)|uniprotkb:KIAA0696(gene name synonym)|uniprotkb:FBXW11(gene name)|psi-mi:FBXW11(display_short)|uniprotkb:BTRCP2(gene name synonym)|uniprotkb:FBW1B(gene name synonym)|uniprotkb:FBXW1B(gene name synonym)|uniprotkb:F-box/WD repeat-containing protein 1B(gene name synonym)|uniprotkb:F-box and WD repeats protein beta-TrCP2(gene name synonym)|uniprotkb:Homologous to Slimb protein(gene name synonym) psi-mi:mpip2_human(display_long)|uniprotkb:Dual specificity phosphatase Cdc25B(gene name synonym)|uniprotkb:CDC25B(gene name)|psi-mi:CDC25B(display_short)|uniprotkb:CDC25HU2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514231|imex:IM-12079-39 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_036432.2|refseq:NP_387448.2|refseq:NP_387449.2|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007097"(nuclear migration)|go:"GO:0007281"(germ cell development)|go:"GO:0008090"(retrograde axonal transport)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031023"(microtubule organizing center organization)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031648"(protein destabilization)|go:"GO:0042753"(positive regulation of circadian rhythm)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0005635"(nuclear envelope)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0070840"(dynein complex binding)|go:"GO:1904115"(axon cytoplasm)|go:"GO:2000574"(obsolete regulation of microtubule motor activity)|interpro:IPR001680(WD40 repeat)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR021977|interpro:IPR036047|interpro:IPR036322|mint:Q9UKB1|rcsb pdb:6WNX|reactome:R-HSA-1169091|reactome:R-HSA-202424|reactome:R-HSA-2565942|reactome:R-HSA-2871837|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5676590|reactome:R-HSA-5684264|reactome:R-HSA-8951664|reactome:R-HSA-983168|go:"GO:0048511"(rhythmic process)|ensembl:ENSG00000072803(gene)|ensembl:ENST00000265094(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000776"(kinetochore)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|dip:DIP-27593N refseq:NP_004349.1|refseq:NP_068658.1|refseq:NP_068659.1|refseq:NP_001274448.1|refseq:NP_001274453.1|ensembl:ENSG00000101224(gene)|ensembl:ENST00000245960(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000922"(spindle pole)|go:"GO:0001556"(oocyte maturation)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007144"(female meiosis I)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0051301"(cell division)|go:"GO:0110032"(positive regulation of G2/MI transition of meiotic cell cycle)|interpro:IPR000751(M-phase inducer phosphatase)|interpro:IPR001763(Rhodanese-like)|interpro:IPR036873|mint:P30305|rcsb pdb:1CWR|rcsb pdb:1CWS|rcsb pdb:1CWT|rcsb pdb:1QB0|rcsb pdb:1YM9|rcsb pdb:1YMD|rcsb pdb:1YMK|rcsb pdb:1YML|rcsb pdb:1YS0|rcsb pdb:2A2K|rcsb pdb:2IFD|rcsb pdb:2IFV|rcsb pdb:2UZQ|rcsb pdb:3FQT|rcsb pdb:3FQU|rcsb pdb:4WH7|rcsb pdb:4WH9|reactome:R-HSA-69273|reactome:R-HSA-69656|reactome:R-HSA-8862803|dip:DIP-323N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/10/11 rogid:8wLc2Pt+mLfRsNwXOnjho+1A0u09606 rogid:okfbcXrQ0dh/TRk/iKOEf6KDNU49606 intact-crc:BD7BBFF01AA5B338|rigid:+kAPRl8AUDqJghroerwJE+BEE9E false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UKB1 uniprotkb:O43847 intact:EBI-355189|uniprotkb:Q9P2S8|uniprotkb:Q9P2S9|uniprotkb:Q9Y4C6|uniprotkb:B2RC98|ensembl:ENSP00000265094 intact:EBI-2371631|uniprotkb:O15241|uniprotkb:O15242|uniprotkb:Q5VUL0|uniprotkb:Q96HB2|uniprotkb:Q9NU57|uniprotkb:A6NI41|ensembl:ENSP00000262679|intact:EBI-6137671 psi-mi:fbw1b_human(display_long)|uniprotkb:KIAA0696(gene name synonym)|uniprotkb:FBXW11(gene name)|psi-mi:FBXW11(display_short)|uniprotkb:BTRCP2(gene name synonym)|uniprotkb:FBW1B(gene name synonym)|uniprotkb:FBXW1B(gene name synonym)|uniprotkb:F-box/WD repeat-containing protein 1B(gene name synonym)|uniprotkb:F-box and WD repeats protein beta-TrCP2(gene name synonym)|uniprotkb:Homologous to Slimb protein(gene name synonym) psi-mi:nrdc_human(display_long)|uniprotkb:NRDC(gene name)|psi-mi:NRDC(display_short)|uniprotkb:N-arginine dibasic convertase(gene name synonym)|uniprotkb:NRD1(gene name synonym)|uniprotkb:Nardilysin convertase(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514231|imex:IM-12079-39 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_036432.2|refseq:NP_387448.2|refseq:NP_387449.2|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007097"(nuclear migration)|go:"GO:0007281"(germ cell development)|go:"GO:0008090"(retrograde axonal transport)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031023"(microtubule organizing center organization)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031648"(protein destabilization)|go:"GO:0042753"(positive regulation of circadian rhythm)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0005635"(nuclear envelope)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0070840"(dynein complex binding)|go:"GO:1904115"(axon cytoplasm)|go:"GO:2000574"(obsolete regulation of microtubule motor activity)|interpro:IPR001680(WD40 repeat)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR021977|interpro:IPR036047|interpro:IPR036322|mint:Q9UKB1|rcsb pdb:6WNX|reactome:R-HSA-1169091|reactome:R-HSA-202424|reactome:R-HSA-2565942|reactome:R-HSA-2871837|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5676590|reactome:R-HSA-5684264|reactome:R-HSA-8951664|reactome:R-HSA-983168|go:"GO:0048511"(rhythmic process)|ensembl:ENSG00000072803(gene)|ensembl:ENST00000265094(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000776"(kinetochore)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|dip:DIP-27593N refseq:NP_001095132.1|refseq:NP_001229290.1|refseq:NP_002516.2|ensembl:ENSG00000078618(gene)|ensembl:ENST00000352171(transcript)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0009986"(cell surface)|go:"GO:0046872"(metal ion binding)|go:"GO:0048408"(epidermal growth factor binding)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0052548"(regulation of endopeptidase activity)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|interpro:IPR001431(Peptidase M16, zinc-binding site)|interpro:IPR007863(Peptidase M16, C-terminal)|interpro:IPR011249(Metalloenzyme, LuxS/M16 peptidase-like, metal-binding)|interpro:IPR011765(Peptidase M16, N-terminal)|interpro:IPR032632|mint:O43847 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/10/11 rogid:8wLc2Pt+mLfRsNwXOnjho+1A0u09606 rogid:zvZTk2Q799M8nsREOYmuYPF/x1U9606 intact-crc:BD7BBFF01AA5B338|rigid:+kAPRl8AUDqJghroerwJE+BEE9E false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UKB1 uniprotkb:Q9Y297 intact:EBI-355189|uniprotkb:Q9P2S8|uniprotkb:Q9P2S9|uniprotkb:Q9Y4C6|uniprotkb:B2RC98|ensembl:ENSP00000265094 intact:EBI-307461|uniprotkb:Q9Y213|uniprotkb:B5MD49|uniprotkb:Q5W142|ensembl:ENSP00000359206|uniprotkb:Q5W141 psi-mi:fbw1b_human(display_long)|uniprotkb:KIAA0696(gene name synonym)|uniprotkb:FBXW11(gene name)|psi-mi:FBXW11(display_short)|uniprotkb:BTRCP2(gene name synonym)|uniprotkb:FBW1B(gene name synonym)|uniprotkb:FBXW1B(gene name synonym)|uniprotkb:F-box/WD repeat-containing protein 1B(gene name synonym)|uniprotkb:F-box and WD repeats protein beta-TrCP2(gene name synonym)|uniprotkb:Homologous to Slimb protein(gene name synonym) psi-mi:fbw1a_human(display_long)|uniprotkb:BTRC(gene name)|psi-mi:BTRC(display_short)|uniprotkb:BTRCP(gene name synonym)|uniprotkb:FBW1A(gene name synonym)|uniprotkb:FBXW1A(gene name synonym)|uniprotkb:F-box and WD repeats protein beta-TrCP(gene name synonym)|uniprotkb:E3RSIkappaB(gene name synonym)|uniprotkb:pIkappaBalpha-E3 receptor subunit(gene name synonym)|uniprotkb:Epididymis tissue protein Li 2a(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514231|imex:IM-12079-39 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_036432.2|refseq:NP_387448.2|refseq:NP_387449.2|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007097"(nuclear migration)|go:"GO:0007281"(germ cell development)|go:"GO:0008090"(retrograde axonal transport)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031023"(microtubule organizing center organization)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031648"(protein destabilization)|go:"GO:0042753"(positive regulation of circadian rhythm)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0005635"(nuclear envelope)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0070840"(dynein complex binding)|go:"GO:1904115"(axon cytoplasm)|go:"GO:2000574"(obsolete regulation of microtubule motor activity)|interpro:IPR001680(WD40 repeat)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR021977|interpro:IPR036047|interpro:IPR036322|mint:Q9UKB1|rcsb pdb:6WNX|reactome:R-HSA-1169091|reactome:R-HSA-202424|reactome:R-HSA-2565942|reactome:R-HSA-2871837|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5676590|reactome:R-HSA-5684264|reactome:R-HSA-8951664|reactome:R-HSA-983168|go:"GO:0048511"(rhythmic process)|ensembl:ENSG00000072803(gene)|ensembl:ENST00000265094(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000776"(kinetochore)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|dip:DIP-27593N refseq:NP_003930.1|refseq:NP_378663.1|ensembl:ENSG00000166167(gene)|ensembl:ENST00000370187(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016874"(ligase activity)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031648"(protein destabilization)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042753"(positive regulation of circadian rhythm)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045309"(protein phosphorylated amino acid binding)|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:1990757"(ubiquitin ligase activator activity)|interpro:IPR001680(WD40 repeat)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|interpro:IPR021977|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|interpro:IPR036047|interpro:IPR036322|mint:Q9Y297|rcsb pdb:1P22|rcsb pdb:2P64|rcsb pdb:6M90|rcsb pdb:6M91|rcsb pdb:6M92|rcsb pdb:6M93|rcsb pdb:6M94|go:"GO:0046983"(protein dimerization activity)|rcsb pdb:6TTU|reactome:R-HSA-1169091|reactome:R-HSA-1170546|go:"GO:0048511"(rhythmic process)|reactome:R-HSA-174113|reactome:R-HSA-180534|reactome:R-HSA-195253|reactome:R-HSA-202424|go:"GO:0051726"(regulation of cell cycle)|reactome:R-HSA-2565942|reactome:R-HSA-2871837|reactome:R-HSA-3769402|reactome:R-HSA-400253|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5676590|reactome:R-HSA-5684264|reactome:R-HSA-8951664|reactome:R-HSA-9020702|reactome:R-HSA-983168|dip:DIP-31607N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/10/11 rogid:8wLc2Pt+mLfRsNwXOnjho+1A0u09606 rogid:9/bXDY6YvJWvP6iMSgOPT9CNGAE9606 intact-crc:BD7BBFF01AA5B338|rigid:+kAPRl8AUDqJghroerwJE+BEE9E false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UKB1 uniprotkb:O15294 intact:EBI-355189|uniprotkb:Q9P2S8|uniprotkb:Q9P2S9|uniprotkb:Q9Y4C6|uniprotkb:B2RC98|ensembl:ENSP00000265094 intact:EBI-539828|uniprotkb:Q7Z3K0|uniprotkb:Q8WWM8|uniprotkb:Q96CC1|uniprotkb:Q9UG57|ensembl:ENSP00000362824 psi-mi:fbw1b_human(display_long)|uniprotkb:KIAA0696(gene name synonym)|uniprotkb:FBXW11(gene name)|psi-mi:FBXW11(display_short)|uniprotkb:BTRCP2(gene name synonym)|uniprotkb:FBW1B(gene name synonym)|uniprotkb:FBXW1B(gene name synonym)|uniprotkb:F-box/WD repeat-containing protein 1B(gene name synonym)|uniprotkb:F-box and WD repeats protein beta-TrCP2(gene name synonym)|uniprotkb:Homologous to Slimb protein(gene name synonym) psi-mi:ogt1_human(display_long)|uniprotkb:O-linked N-acetylglucosamine transferase 110 kDa subunit(gene name synonym)|uniprotkb:O-GlcNAc transferase subunit p110(gene name synonym)|uniprotkb:OGT(gene name)|psi-mi:OGT(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514231|imex:IM-12079-39 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_036432.2|refseq:NP_387448.2|refseq:NP_387449.2|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007097"(nuclear migration)|go:"GO:0007281"(germ cell development)|go:"GO:0008090"(retrograde axonal transport)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031023"(microtubule organizing center organization)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031648"(protein destabilization)|go:"GO:0042753"(positive regulation of circadian rhythm)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0005635"(nuclear envelope)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0070840"(dynein complex binding)|go:"GO:1904115"(axon cytoplasm)|go:"GO:2000574"(obsolete regulation of microtubule motor activity)|interpro:IPR001680(WD40 repeat)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR021977|interpro:IPR036047|interpro:IPR036322|mint:Q9UKB1|rcsb pdb:6WNX|reactome:R-HSA-1169091|reactome:R-HSA-202424|reactome:R-HSA-2565942|reactome:R-HSA-2871837|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5676590|reactome:R-HSA-5684264|reactome:R-HSA-8951664|reactome:R-HSA-983168|go:"GO:0048511"(rhythmic process)|ensembl:ENSG00000072803(gene)|ensembl:ENST00000265094(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000776"(kinetochore)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|dip:DIP-27593N refseq:NP_858058.1|refseq:NP_858059.1|rcsb pdb:3PE3|rcsb pdb:3PE4|rcsb pdb:3TAX|rcsb pdb:4AY5|rcsb pdb:4AY6|rcsb pdb:4CDR|rcsb pdb:4GYW|rcsb pdb:4GYY|rcsb pdb:4GZ3|rcsb pdb:4GZ5|rcsb pdb:4GZ6|rcsb pdb:4N39|rcsb pdb:4N3A|rcsb pdb:1W3B|rcsb pdb:4N3B|rcsb pdb:4N3C|rcsb pdb:4XI9|rcsb pdb:4XIF|rcsb pdb:5BNW|rcsb pdb:5C1D|rcsb pdb:5HGV|rcsb pdb:5LVV|rcsb pdb:5LWV|rcsb pdb:5NPR|rcsb pdb:5NPS|rcsb pdb:5VIE|rcsb pdb:5VIF|rcsb pdb:6E37|rcsb pdb:6EOU|rcsb pdb:6IBO|rcsb pdb:6MA2|rcsb pdb:6MA3|rcsb pdb:6MA4|rcsb pdb:6MA5|rcsb pdb:6Q4M|rcsb pdb:6TKA|reactome:R-HSA-3214847|reactome:R-HSA-5213460|reactome:R-HSA-5675482|reactome:R-HSA-5689603|rcsb pdb:6MA1|ensembl:ENSG00000147162(gene)|ensembl:ENST00000373719(transcript)|go:"GO:0000123"(histone acetyltransferase complex)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006110"(regulation of glycolytic process)|go:"GO:0006111"(regulation of gluconeogenesis)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006493"(protein O-linked glycosylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007584"(response to nutrient)|go:"GO:0008375"(acetylglucosaminyltransferase activity)|go:"GO:0016262"(protein N-acetylglucosaminyltransferase activity)|go:"GO:0016485"(protein processing)|go:"GO:0017122"(protein N-acetylglucosaminyltransferase complex)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032868"(response to insulin)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035020"(regulation of Rac protein signal transduction)|go:"GO:0043981"(histone H4-K5 acetylation)|go:"GO:0043982"(histone H4-K8 acetylation)|go:"GO:0043984"(histone H4-K16 acetylation)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0060544"(regulation of necroptotic process)|go:"GO:0061087"(positive regulation of histone H3-K27 methylation)|go:"GO:0080182"(histone H3-K4 trimethylation)|go:"GO:0097363"(protein O-GlcNAc transferase activity)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR029489|interpro:IPR037919|mint:O15294|go:"GO:0042995"(cell projection)|refseq:XP_016885396.1|refseq:XP_016885397.1|dip:DIP-33491N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/10/11 rogid:8wLc2Pt+mLfRsNwXOnjho+1A0u09606 rogid:NmuVFHeg1QRYMbVav6e7fRJft5U9606 intact-crc:BD7BBFF01AA5B338|rigid:+kAPRl8AUDqJghroerwJE+BEE9E false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UKB1 uniprotkb:Q01664 intact:EBI-355189|uniprotkb:Q9P2S8|uniprotkb:Q9P2S9|uniprotkb:Q9Y4C6|uniprotkb:B2RC98|ensembl:ENSP00000265094 intact:EBI-2514218|ensembl:ENSP00000204517|uniprotkb:O60409 psi-mi:fbw1b_human(display_long)|uniprotkb:KIAA0696(gene name synonym)|uniprotkb:FBXW11(gene name)|psi-mi:FBXW11(display_short)|uniprotkb:BTRCP2(gene name synonym)|uniprotkb:FBW1B(gene name synonym)|uniprotkb:FBXW1B(gene name synonym)|uniprotkb:F-box/WD repeat-containing protein 1B(gene name synonym)|uniprotkb:F-box and WD repeats protein beta-TrCP2(gene name synonym)|uniprotkb:Homologous to Slimb protein(gene name synonym) psi-mi:tfap4_human(display_long)|uniprotkb:TFAP4(gene name)|psi-mi:TFAP4(display_short)|uniprotkb:Activating enhancer-binding protein 4(gene name synonym)|uniprotkb:BHLHC41(gene name synonym)|uniprotkb:Class C basic helix-loop-helix protein 41(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514231|imex:IM-12079-39 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_036432.2|refseq:NP_387448.2|refseq:NP_387449.2|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007097"(nuclear migration)|go:"GO:0007281"(germ cell development)|go:"GO:0008090"(retrograde axonal transport)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031023"(microtubule organizing center organization)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031648"(protein destabilization)|go:"GO:0042753"(positive regulation of circadian rhythm)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0005635"(nuclear envelope)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0070840"(dynein complex binding)|go:"GO:1904115"(axon cytoplasm)|go:"GO:2000574"(obsolete regulation of microtubule motor activity)|interpro:IPR001680(WD40 repeat)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR021977|interpro:IPR036047|interpro:IPR036322|mint:Q9UKB1|rcsb pdb:6WNX|reactome:R-HSA-1169091|reactome:R-HSA-202424|reactome:R-HSA-2565942|reactome:R-HSA-2871837|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5676590|reactome:R-HSA-5684264|reactome:R-HSA-8951664|reactome:R-HSA-983168|go:"GO:0048511"(rhythmic process)|ensembl:ENSG00000072803(gene)|ensembl:ENST00000265094(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000776"(kinetochore)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|dip:DIP-27593N ensembl:ENSG00000090447(gene)|ensembl:ENST00000204517(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0043923"(positive regulation by host of viral transcription)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070888"(E-box binding)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:1901990"(regulation of mitotic cell cycle phase transition)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006978"(DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043922"(negative regulation by host of viral transcription)|refseq:NP_003214.1|dip:DIP-53627N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/10/11 rogid:8wLc2Pt+mLfRsNwXOnjho+1A0u09606 rogid:WNpFrsmcAWD2UAtTlQzXoUAmFU09606 intact-crc:BD7BBFF01AA5B338|rigid:+kAPRl8AUDqJghroerwJE+BEE9E false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UKB1 uniprotkb:Q9UGI0 intact:EBI-355189|uniprotkb:Q9P2S8|uniprotkb:Q9P2S9|uniprotkb:Q9Y4C6|uniprotkb:B2RC98|ensembl:ENSP00000265094 intact:EBI-527853|uniprotkb:Q5SQP6|uniprotkb:B4DZ98|uniprotkb:Q69YK3|uniprotkb:D3DRF4|ensembl:ENSP00000352676 psi-mi:fbw1b_human(display_long)|uniprotkb:KIAA0696(gene name synonym)|uniprotkb:FBXW11(gene name)|psi-mi:FBXW11(display_short)|uniprotkb:BTRCP2(gene name synonym)|uniprotkb:FBW1B(gene name synonym)|uniprotkb:FBXW1B(gene name synonym)|uniprotkb:F-box/WD repeat-containing protein 1B(gene name synonym)|uniprotkb:F-box and WD repeats protein beta-TrCP2(gene name synonym)|uniprotkb:Homologous to Slimb protein(gene name synonym) psi-mi:zran1_human(display_long)|uniprotkb:Zinc finger Ran-binding domain-containing protein 1(gene name synonym)|uniprotkb:ZRANB1(gene name)|psi-mi:ZRANB1(display_short)|uniprotkb:TRABID(gene name synonym)|uniprotkb:TRAF-binding domain-containing protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514231|imex:IM-12079-39 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_036432.2|refseq:NP_387448.2|refseq:NP_387449.2|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007097"(nuclear migration)|go:"GO:0007281"(germ cell development)|go:"GO:0008090"(retrograde axonal transport)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031023"(microtubule organizing center organization)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031648"(protein destabilization)|go:"GO:0042753"(positive regulation of circadian rhythm)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0005635"(nuclear envelope)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0070840"(dynein complex binding)|go:"GO:1904115"(axon cytoplasm)|go:"GO:2000574"(obsolete regulation of microtubule motor activity)|interpro:IPR001680(WD40 repeat)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR021977|interpro:IPR036047|interpro:IPR036322|mint:Q9UKB1|rcsb pdb:6WNX|reactome:R-HSA-1169091|reactome:R-HSA-202424|reactome:R-HSA-2565942|reactome:R-HSA-2871837|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5676590|reactome:R-HSA-5684264|reactome:R-HSA-8951664|reactome:R-HSA-983168|go:"GO:0048511"(rhythmic process)|ensembl:ENSG00000072803(gene)|ensembl:ENST00000265094(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000776"(kinetochore)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|dip:DIP-27593N refseq:NP_060050.2|ensembl:ENSG00000019995(gene)|ensembl:ENST00000359653(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016477"(cell migration)|go:"GO:0022604"(regulation of cell morphogenesis)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0035523"(protein K29-linked deubiquitination)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046872"(metal ion binding)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0071947"(protein deubiquitination involved in ubiquitin-dependent protein catabolic process)|go:"GO:1990168"(protein K33-linked deubiquitination)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR003323(Ovarian tumour, otubain)|interpro:IPR036443|interpro:IPR041294|mint:Q9UGI0|rcsb pdb:3ZRH|rcsb pdb:5AF6|reactome:R-HSA-195253|reactome:R-HSA-5689896|refseq:XP_005269983.1|dip:DIP-33806N|refseq:XP_016871846.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/10/11 rogid:8wLc2Pt+mLfRsNwXOnjho+1A0u09606 rogid:/cHOFsN7yB+8MUyL3cAG1v5MUAc9606 intact-crc:BD7BBFF01AA5B338|rigid:+kAPRl8AUDqJghroerwJE+BEE9E false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UKB1 uniprotkb:Q9Y4X5 intact:EBI-355189|uniprotkb:Q9P2S8|uniprotkb:Q9P2S9|uniprotkb:Q9Y4C6|uniprotkb:B2RC98|ensembl:ENSP00000265094 intact:EBI-2514233|ensembl:ENSP00000369217|uniprotkb:Q9UEN0|uniprotkb:Q9H3T6|uniprotkb:O76026|uniprotkb:Q9UP39|uniprotkb:B2R6U3 psi-mi:fbw1b_human(display_long)|uniprotkb:KIAA0696(gene name synonym)|uniprotkb:FBXW11(gene name)|psi-mi:FBXW11(display_short)|uniprotkb:BTRCP2(gene name synonym)|uniprotkb:FBW1B(gene name synonym)|uniprotkb:FBXW1B(gene name synonym)|uniprotkb:F-box/WD repeat-containing protein 1B(gene name synonym)|uniprotkb:F-box and WD repeats protein beta-TrCP2(gene name synonym)|uniprotkb:Homologous to Slimb protein(gene name synonym) psi-mi:ari1_human(display_long)|uniprotkb:Protein ariadne-1 homolog(gene name synonym)|uniprotkb:ARIH1(gene name)|psi-mi:ARIH1(display_short)|uniprotkb:ARI(gene name synonym)|uniprotkb:MOP6(gene name synonym)|uniprotkb:UBCH7BP(gene name synonym)|uniprotkb:Ubiquitin-conjugating enzyme E2-binding protein 1(gene name synonym)|uniprotkb:UbcH7-binding protein(gene name synonym)|uniprotkb:UbcM4-interacting protein(gene name synonym)|uniprotkb:HHARI(gene name synonym)|uniprotkb:H7-AP2(gene name synonym)|uniprotkb:Monocyte protein 6(gene name synonym)|uniprotkb:HUSSY-27(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514231|imex:IM-12079-39 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_036432.2|refseq:NP_387448.2|refseq:NP_387449.2|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007097"(nuclear migration)|go:"GO:0007281"(germ cell development)|go:"GO:0008090"(retrograde axonal transport)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031023"(microtubule organizing center organization)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031648"(protein destabilization)|go:"GO:0042753"(positive regulation of circadian rhythm)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0005635"(nuclear envelope)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0070840"(dynein complex binding)|go:"GO:1904115"(axon cytoplasm)|go:"GO:2000574"(obsolete regulation of microtubule motor activity)|interpro:IPR001680(WD40 repeat)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR021977|interpro:IPR036047|interpro:IPR036322|mint:Q9UKB1|rcsb pdb:6WNX|reactome:R-HSA-1169091|reactome:R-HSA-202424|reactome:R-HSA-2565942|reactome:R-HSA-2871837|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5676590|reactome:R-HSA-5684264|reactome:R-HSA-8951664|reactome:R-HSA-983168|go:"GO:0048511"(rhythmic process)|ensembl:ENSG00000072803(gene)|ensembl:ENST00000265094(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000776"(kinetochore)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|dip:DIP-27593N ensembl:ENSG00000166233(gene)|ensembl:ENST00000379887(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015030"(Cajal body)|go:"GO:0016604"(nuclear body)|go:"GO:0019787"(ubiquitin-like protein transferase activity)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0097413"(Lewy body)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002867(Zinc finger, C6HC-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR031127|interpro:IPR044066|mint:Q9Y4X5|rcsb pdb:1WD2|rcsb pdb:2M9Y|rcsb pdb:4KBL|rcsb pdb:4KC9|rcsb pdb:5TTE|rcsb pdb:5UDH|rcsb pdb:7B5L|rcsb pdb:7B5M|rcsb pdb:7B5N|rcsb pdb:7B5S|reactome:R-HSA-1169408|go:"GO:0016567"(protein ubiquitination)|refseq:NP_005735.2|dip:DIP-53626N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/10/11 rogid:8wLc2Pt+mLfRsNwXOnjho+1A0u09606 rogid:4au2wa0c7NccURO3aKdmKN0U3PE9606 intact-crc:BD7BBFF01AA5B338|rigid:+kAPRl8AUDqJghroerwJE+BEE9E false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UKB1 uniprotkb:P31629 intact:EBI-355189|uniprotkb:Q9P2S8|uniprotkb:Q9P2S9|uniprotkb:Q9Y4C6|uniprotkb:B2RC98|ensembl:ENSP00000265094 intact:EBI-2514157|ensembl:ENSP00000012134|ensembl:ENSP00000356575|ensembl:ENSP00000356576|uniprotkb:Q02646|uniprotkb:Q9NS05|uniprotkb:Q5THT5 psi-mi:fbw1b_human(display_long)|uniprotkb:KIAA0696(gene name synonym)|uniprotkb:FBXW11(gene name)|psi-mi:FBXW11(display_short)|uniprotkb:BTRCP2(gene name synonym)|uniprotkb:FBW1B(gene name synonym)|uniprotkb:FBXW1B(gene name synonym)|uniprotkb:F-box/WD repeat-containing protein 1B(gene name synonym)|uniprotkb:F-box and WD repeats protein beta-TrCP2(gene name synonym)|uniprotkb:Homologous to Slimb protein(gene name synonym) psi-mi:zep2_human(display_long)|uniprotkb:HIVEP2(gene name)|psi-mi:HIVEP2(display_short)|uniprotkb:Human immunodeficiency virus type I enhancer-binding protein 2(gene name synonym)|uniprotkb:MHC-binding protein 2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514231|imex:IM-12079-39 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_036432.2|refseq:NP_387448.2|refseq:NP_387449.2|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007097"(nuclear migration)|go:"GO:0007281"(germ cell development)|go:"GO:0008090"(retrograde axonal transport)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031023"(microtubule organizing center organization)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031648"(protein destabilization)|go:"GO:0042753"(positive regulation of circadian rhythm)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0005635"(nuclear envelope)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0070840"(dynein complex binding)|go:"GO:1904115"(axon cytoplasm)|go:"GO:2000574"(obsolete regulation of microtubule motor activity)|interpro:IPR001680(WD40 repeat)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR021977|interpro:IPR036047|interpro:IPR036322|mint:Q9UKB1|rcsb pdb:6WNX|reactome:R-HSA-1169091|reactome:R-HSA-202424|reactome:R-HSA-2565942|reactome:R-HSA-2871837|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5676590|reactome:R-HSA-5684264|reactome:R-HSA-8951664|reactome:R-HSA-983168|go:"GO:0048511"(rhythmic process)|ensembl:ENSG00000072803(gene)|ensembl:ENST00000265094(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000776"(kinetochore)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|dip:DIP-27593N ensembl:ENSG00000010818(gene)|ensembl:ENST00000012134(transcript)|ensembl:ENST00000367603(transcript)|ensembl:ENST00000367604(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|refseq:XP_016866294.1|refseq:NP_006725.3 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/10/11 rogid:8wLc2Pt+mLfRsNwXOnjho+1A0u09606 rogid:/QXXmthWJq/FkgWwIqkVb1z16EU9606 intact-crc:BD7BBFF01AA5B338|rigid:+kAPRl8AUDqJghroerwJE+BEE9E false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UKB1 uniprotkb:Q53EL6 intact:EBI-355189|uniprotkb:Q9P2S8|uniprotkb:Q9P2S9|uniprotkb:Q9Y4C6|uniprotkb:B2RC98|ensembl:ENSP00000265094 intact:EBI-935824|uniprotkb:O15501|uniprotkb:Q5VZS6|uniprotkb:Q6PJI5|uniprotkb:Q8TAR5|uniprotkb:Q99834|intact:EBI-2514227|uniprotkb:B2RCV4|uniprotkb:B5ME91|ensembl:ENSP00000280154 psi-mi:fbw1b_human(display_long)|uniprotkb:KIAA0696(gene name synonym)|uniprotkb:FBXW11(gene name)|psi-mi:FBXW11(display_short)|uniprotkb:BTRCP2(gene name synonym)|uniprotkb:FBW1B(gene name synonym)|uniprotkb:FBXW1B(gene name synonym)|uniprotkb:F-box/WD repeat-containing protein 1B(gene name synonym)|uniprotkb:F-box and WD repeats protein beta-TrCP2(gene name synonym)|uniprotkb:Homologous to Slimb protein(gene name synonym) psi-mi:pdcd4_human(display_long)|uniprotkb:PDCD4(gene name)|psi-mi:PDCD4(display_short)|uniprotkb:H731(gene name synonym)|uniprotkb:Nuclear antigen H731-like(gene name synonym)|uniprotkb:Neoplastic transformation inhibitor protein(gene name synonym)|uniprotkb:Protein 197/15a(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514231|imex:IM-12079-39 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_036432.2|refseq:NP_387448.2|refseq:NP_387449.2|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007097"(nuclear migration)|go:"GO:0007281"(germ cell development)|go:"GO:0008090"(retrograde axonal transport)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031023"(microtubule organizing center organization)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031648"(protein destabilization)|go:"GO:0042753"(positive regulation of circadian rhythm)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0005635"(nuclear envelope)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0070840"(dynein complex binding)|go:"GO:1904115"(axon cytoplasm)|go:"GO:2000574"(obsolete regulation of microtubule motor activity)|interpro:IPR001680(WD40 repeat)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR021977|interpro:IPR036047|interpro:IPR036322|mint:Q9UKB1|rcsb pdb:6WNX|reactome:R-HSA-1169091|reactome:R-HSA-202424|reactome:R-HSA-2565942|reactome:R-HSA-2871837|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5676590|reactome:R-HSA-5684264|reactome:R-HSA-8951664|reactome:R-HSA-983168|go:"GO:0048511"(rhythmic process)|ensembl:ENSG00000072803(gene)|ensembl:ENST00000265094(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000776"(kinetochore)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|dip:DIP-27593N refseq:NP_055271.2|refseq:NP_663314.1|dip:DIP-29756N|ensembl:ENSG00000150593(gene)|ensembl:ENST00000280154(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007569"(cell aging)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043508"(negative regulation of JUN kinase activity)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0060940"(epithelial to mesenchymal transition involved in cardiac fibroblast development)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904761"(negative regulation of myofibroblast differentiation)|go:"GO:1905064"(negative regulation of vascular associated smooth muscle cell differentiation)|go:"GO:1905461"(positive regulation of vascular associated smooth muscle cell apoptotic process)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|interpro:IPR003891(Initiation factor eIF-4 gamma, MA3)|interpro:IPR016021(MIF4-like, type 1/2/3)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR039778|rcsb pdb:2GGF|rcsb pdb:2KZT|rcsb pdb:2RG8|rcsb pdb:2ZU6|rcsb pdb:3EIJ|reactome:R-HSA-8950505 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/10/11 rogid:8wLc2Pt+mLfRsNwXOnjho+1A0u09606 rogid:kkqDk2CCFvHpSCKNDzV4wqSm1HE9606 intact-crc:BD7BBFF01AA5B338|rigid:+kAPRl8AUDqJghroerwJE+BEE9E false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UKB1 uniprotkb:Q86T82 intact:EBI-355189|uniprotkb:Q9P2S8|uniprotkb:Q9P2S9|uniprotkb:Q9Y4C6|uniprotkb:B2RC98|ensembl:ENSP00000265094 intact:EBI-2513613|intact:EBI-2514223|uniprotkb:B7ZM38|uniprotkb:B7ZM41|uniprotkb:Q7Z3A5|uniprotkb:E9PHL3|uniprotkb:Q2KHT2|ensembl:ENSP00000258399|ensembl:ENSP00000393662|ensembl:ENSP00000396585|uniprotkb:Q9HCH8|uniprotkb:A2RUQ8|uniprotkb:Q53S10 psi-mi:fbw1b_human(display_long)|uniprotkb:KIAA0696(gene name synonym)|uniprotkb:FBXW11(gene name)|psi-mi:FBXW11(display_short)|uniprotkb:BTRCP2(gene name synonym)|uniprotkb:FBW1B(gene name synonym)|uniprotkb:FBXW1B(gene name synonym)|uniprotkb:F-box/WD repeat-containing protein 1B(gene name synonym)|uniprotkb:F-box and WD repeats protein beta-TrCP2(gene name synonym)|uniprotkb:Homologous to Slimb protein(gene name synonym) psi-mi:ubp37_human(display_long)|uniprotkb:USP37(gene name)|psi-mi:USP37(display_short)|uniprotkb:KIAA1594(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 37(gene name synonym)|uniprotkb:Deubiquitinating enzyme 37(gene name synonym)|uniprotkb:Ubiquitin thioesterase 37(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514231|imex:IM-12079-39 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_036432.2|refseq:NP_387448.2|refseq:NP_387449.2|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007097"(nuclear migration)|go:"GO:0007281"(germ cell development)|go:"GO:0008090"(retrograde axonal transport)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031023"(microtubule organizing center organization)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031648"(protein destabilization)|go:"GO:0042753"(positive regulation of circadian rhythm)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0005635"(nuclear envelope)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0070840"(dynein complex binding)|go:"GO:1904115"(axon cytoplasm)|go:"GO:2000574"(obsolete regulation of microtubule motor activity)|interpro:IPR001680(WD40 repeat)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR021977|interpro:IPR036047|interpro:IPR036322|mint:Q9UKB1|rcsb pdb:6WNX|reactome:R-HSA-1169091|reactome:R-HSA-202424|reactome:R-HSA-2565942|reactome:R-HSA-2871837|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5676590|reactome:R-HSA-5684264|reactome:R-HSA-8951664|reactome:R-HSA-983168|go:"GO:0048511"(rhythmic process)|ensembl:ENSG00000072803(gene)|ensembl:ENST00000265094(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000776"(kinetochore)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|dip:DIP-27593N go:"GO:0006275"(regulation of DNA replication)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019901"(protein kinase binding)|go:"GO:0035871"(protein K11-linked deubiquitination)|go:"GO:0051301"(cell division)|go:"GO:0071108"(protein K48-linked deubiquitination)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR018200|interpro:IPR028889|interpro:IPR032069|interpro:IPR038093|go:"GO:0005829"(cytosol)|interpro:IPR038765|rcsb pdb:3U12|reactome:R-HSA-5689880|ensembl:ENSG00000135913(gene)|ensembl:ENST00000258399(transcript)|ensembl:ENST00000418019(transcript)|ensembl:ENST00000454775(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|refseq:XP_011509840.1|refseq:NP_065986.2|refseq:XP_005246777.1|refseq:XP_005246778.1|refseq:XP_005246779.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/10/11 rogid:8wLc2Pt+mLfRsNwXOnjho+1A0u09606 rogid:2DOjCrilHkv+l0r0zBQ1td2p+qc9606 intact-crc:BD7BBFF01AA5B338|rigid:+kAPRl8AUDqJghroerwJE+BEE9E false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UN86 uniprotkb:Q8NI36 intact:EBI-1044298|uniprotkb:O60606|uniprotkb:O75149|uniprotkb:Q9UPA1|ensembl:ENSP00000352738|ensembl:ENSP00000379069|ensembl:ENSP00000503228|ensembl:ENSP00000503239|ensembl:ENSP00000503355|ensembl:ENSP00000503669|ensembl:ENSP00000503911|ensembl:ENSP00000503943|ensembl:ENSP00000504101|ensembl:ENSP00000504159|ensembl:ENSP00000504316|ensembl:ENSP00000504361|ensembl:ENSP00000504371|ensembl:ENSP00000504496|ensembl:ENSP00000504523|ensembl:ENSP00000504585|ensembl:ENSP00000504698|ensembl:ENSP00000503504|uniprotkb:A8K6X1 intact:EBI-2512413|ensembl:ENSP00000423067|ensembl:ENSP00000479950|uniprotkb:A2RUS4|uniprotkb:Q8N1Q2|uniprotkb:Q68E02 psi-mi:g3bp2_human(display_long)|uniprotkb:GAP SH3 domain-binding protein 2(gene name synonym)|uniprotkb:G3BP2(gene name)|psi-mi:G3BP2(display_short)|uniprotkb:KIAA0660(gene name synonym) psi-mi:wdr36_human(display_long)|uniprotkb:WDR36(gene name)|psi-mi:WDR36(display_short)|uniprotkb:T-cell activation WD repeat-containing protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514381|imex:IM-12079-40 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_036429.2|refseq:NP_987100.1|refseq:NP_987101.1|ensembl:ENSG00000138757(gene)|ensembl:ENST00000677620(transcript)|ensembl:ENST00000678062(transcript)|ensembl:ENST00000678100(transcript)|ensembl:ENST00000678123(transcript)|ensembl:ENST00000678265(transcript)|ensembl:ENST00000678578(transcript)|ensembl:ENST00000678798(transcript)|ensembl:ENST00000678971(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007253"(cytoplasmic sequestering of NF-kappaB)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0034063"(stress granule assembly)|go:"GO:0045087"(innate immune response)|go:"GO:0051028"(mRNA transport)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0062029"(positive regulation of stress granule assembly)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR002075(Nuclear transport factor 2)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR018222|interpro:IPR032710|interpro:IPR034376|interpro:IPR034377|interpro:IPR035979|interpro:IPR039539|mint:Q9UN86|rcsb pdb:5DRV|ensembl:ENST00000359707(transcript)|ensembl:ENST00000395719(transcript)|ensembl:ENST00000676584(transcript)|ensembl:ENST00000676974(transcript)|ensembl:ENST00000677162(transcript)|ensembl:ENST00000677171(transcript)|ensembl:ENST00000677201(transcript)|ensembl:ENST00000677333(transcript)|ensembl:ENST00000677566(transcript)|ensembl:ENST00000677606(transcript)|refseq:XP_011530743.1|refseq:XP_005263439.1|refseq:XP_005263440.1|refseq:XP_016864365.1|refseq:XP_016864366.1|refseq:XP_016864367.1|refseq:XP_016864368.1|dip:DIP-50299N ensembl:ENSG00000134987(gene)|ensembl:ENST00000506538(transcript)|ensembl:ENST00000612402(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006364"(rRNA processing)|go:"GO:0007601"(visual perception)|go:"GO:0032040"(small-subunit processome)|go:"GO:0034388"(Pwp2p-containing subcomplex of 90S preribosome)|go:"GO:0050896"(response to stimulus)|interpro:IPR001680(WD40 repeat)|interpro:IPR007319(Small-subunit processome, Utp21)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR024977|interpro:IPR036322|reactome:R-HSA-6790901|reactome:R-HSA-6791226|go:"GO:0003723"(RNA binding)|refseq:NP_644810.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:bYP8U2wviIqJBWcnLQnuoV0MhV89606 rogid:97Qc0ehUPTjCBcn3gjr0FY8Nnus9606 intact-crc:B0F3248A2A41773A|rigid:0TNucBI9yYzg+HXsmwovpmYCTDM false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UN86 uniprotkb:Q8N3C0 intact:EBI-1044298|uniprotkb:O60606|uniprotkb:O75149|uniprotkb:Q9UPA1|ensembl:ENSP00000352738|ensembl:ENSP00000379069|ensembl:ENSP00000503228|ensembl:ENSP00000503239|ensembl:ENSP00000503355|ensembl:ENSP00000503669|ensembl:ENSP00000503911|ensembl:ENSP00000503943|ensembl:ENSP00000504101|ensembl:ENSP00000504159|ensembl:ENSP00000504316|ensembl:ENSP00000504361|ensembl:ENSP00000504371|ensembl:ENSP00000504496|ensembl:ENSP00000504523|ensembl:ENSP00000504585|ensembl:ENSP00000504698|ensembl:ENSP00000503504|uniprotkb:A8K6X1 intact:EBI-1210710|uniprotkb:Q9NTR0|uniprotkb:O43738|uniprotkb:Q5VTN2|uniprotkb:Q9H1I9|uniprotkb:E7EW23|uniprotkb:Q4G1A0|uniprotkb:Q9H5A2|ensembl:ENSP00000358159 psi-mi:g3bp2_human(display_long)|uniprotkb:GAP SH3 domain-binding protein 2(gene name synonym)|uniprotkb:G3BP2(gene name)|psi-mi:G3BP2(display_short)|uniprotkb:KIAA0660(gene name synonym) psi-mi:ascc3_human(display_long)|uniprotkb:ASCC3(gene name)|psi-mi:ASCC3(display_short)|uniprotkb:HELIC1(gene name synonym)|uniprotkb:ASC-1 complex subunit p200(gene name synonym)|uniprotkb:Trip4 complex subunit p200(gene name synonym)|uniprotkb:Helicase, ATP binding 1(gene name synonym)|uniprotkb:RQT2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514381|imex:IM-12079-40 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_036429.2|refseq:NP_987100.1|refseq:NP_987101.1|ensembl:ENSG00000138757(gene)|ensembl:ENST00000677620(transcript)|ensembl:ENST00000678062(transcript)|ensembl:ENST00000678100(transcript)|ensembl:ENST00000678123(transcript)|ensembl:ENST00000678265(transcript)|ensembl:ENST00000678578(transcript)|ensembl:ENST00000678798(transcript)|ensembl:ENST00000678971(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007253"(cytoplasmic sequestering of NF-kappaB)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0034063"(stress granule assembly)|go:"GO:0045087"(innate immune response)|go:"GO:0051028"(mRNA transport)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0062029"(positive regulation of stress granule assembly)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR002075(Nuclear transport factor 2)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR018222|interpro:IPR032710|interpro:IPR034376|interpro:IPR034377|interpro:IPR035979|interpro:IPR039539|mint:Q9UN86|rcsb pdb:5DRV|ensembl:ENST00000359707(transcript)|ensembl:ENST00000395719(transcript)|ensembl:ENST00000676584(transcript)|ensembl:ENST00000676974(transcript)|ensembl:ENST00000677162(transcript)|ensembl:ENST00000677171(transcript)|ensembl:ENST00000677201(transcript)|ensembl:ENST00000677333(transcript)|ensembl:ENST00000677566(transcript)|ensembl:ENST00000677606(transcript)|refseq:XP_011530743.1|refseq:XP_005263439.1|refseq:XP_005263440.1|refseq:XP_016864365.1|refseq:XP_016864366.1|refseq:XP_016864367.1|refseq:XP_016864368.1|dip:DIP-50299N refseq:NP_001271200.1|refseq:NP_006819.2|refseq:NP_071374.1|ensembl:ENSG00000112249(gene)|ensembl:ENST00000369162(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006307"(DNA dealkylation involved in DNA repair)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0043138"(3'-5' DNA helicase activity)|go:"GO:0099053"(activating signal cointegrator 1 complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR004179(Sec63)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR027417|interpro:IPR035892|interpro:IPR036388|interpro:IPR036390|mint:Q8N3C0|rcsb pdb:6YXQ|reactome:R-HSA-112126|go:"GO:0005829"(cytosol) psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:bYP8U2wviIqJBWcnLQnuoV0MhV89606 rogid:HAdhxBtWHxdw7k0GkyqBtloVyPY9606 intact-crc:B0F3248A2A41773A|rigid:0TNucBI9yYzg+HXsmwovpmYCTDM false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UN86 uniprotkb:Q13206 intact:EBI-1044298|uniprotkb:O60606|uniprotkb:O75149|uniprotkb:Q9UPA1|ensembl:ENSP00000352738|ensembl:ENSP00000379069|ensembl:ENSP00000503228|ensembl:ENSP00000503239|ensembl:ENSP00000503355|ensembl:ENSP00000503669|ensembl:ENSP00000503911|ensembl:ENSP00000503943|ensembl:ENSP00000504101|ensembl:ENSP00000504159|ensembl:ENSP00000504316|ensembl:ENSP00000504361|ensembl:ENSP00000504371|ensembl:ENSP00000504496|ensembl:ENSP00000504523|ensembl:ENSP00000504585|ensembl:ENSP00000504698|ensembl:ENSP00000503504|uniprotkb:A8K6X1 intact:EBI-2514399|ensembl:ENSP00000314348|uniprotkb:Q5BJD8|uniprotkb:B2RCQ3 psi-mi:g3bp2_human(display_long)|uniprotkb:GAP SH3 domain-binding protein 2(gene name synonym)|uniprotkb:G3BP2(gene name)|psi-mi:G3BP2(display_short)|uniprotkb:KIAA0660(gene name synonym) psi-mi:ddx10_human(display_long)|uniprotkb:DDX10(gene name)|psi-mi:DDX10(display_short)|uniprotkb:DEAD box protein 10(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514381|imex:IM-12079-40 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_036429.2|refseq:NP_987100.1|refseq:NP_987101.1|ensembl:ENSG00000138757(gene)|ensembl:ENST00000677620(transcript)|ensembl:ENST00000678062(transcript)|ensembl:ENST00000678100(transcript)|ensembl:ENST00000678123(transcript)|ensembl:ENST00000678265(transcript)|ensembl:ENST00000678578(transcript)|ensembl:ENST00000678798(transcript)|ensembl:ENST00000678971(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007253"(cytoplasmic sequestering of NF-kappaB)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0034063"(stress granule assembly)|go:"GO:0045087"(innate immune response)|go:"GO:0051028"(mRNA transport)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0062029"(positive regulation of stress granule assembly)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR002075(Nuclear transport factor 2)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR018222|interpro:IPR032710|interpro:IPR034376|interpro:IPR034377|interpro:IPR035979|interpro:IPR039539|mint:Q9UN86|rcsb pdb:5DRV|ensembl:ENST00000359707(transcript)|ensembl:ENST00000395719(transcript)|ensembl:ENST00000676584(transcript)|ensembl:ENST00000676974(transcript)|ensembl:ENST00000677162(transcript)|ensembl:ENST00000677171(transcript)|ensembl:ENST00000677201(transcript)|ensembl:ENST00000677333(transcript)|ensembl:ENST00000677566(transcript)|ensembl:ENST00000677606(transcript)|refseq:XP_011530743.1|refseq:XP_005263439.1|refseq:XP_005263440.1|refseq:XP_016864365.1|refseq:XP_016864366.1|refseq:XP_016864367.1|refseq:XP_016864368.1|dip:DIP-50299N ensembl:ENSG00000178105(gene)|ensembl:ENST00000322536(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0006364"(rRNA processing)|go:"GO:0097065"(anterior head development)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR000629(RNA helicase, ATP-dependent, DEAD-box, conserved site)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR025313|interpro:IPR027417|mint:Q13206|rcsb pdb:2PL3|refseq:NP_004389.2 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:bYP8U2wviIqJBWcnLQnuoV0MhV89606 rogid:MMAbABrYQHlYDyPsagT7oY92Z3M9606 intact-crc:B0F3248A2A41773A|rigid:0TNucBI9yYzg+HXsmwovpmYCTDM false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UN86 uniprotkb:P37198 intact:EBI-1044298|uniprotkb:O60606|uniprotkb:O75149|uniprotkb:Q9UPA1|ensembl:ENSP00000352738|ensembl:ENSP00000379069|ensembl:ENSP00000503228|ensembl:ENSP00000503239|ensembl:ENSP00000503355|ensembl:ENSP00000503669|ensembl:ENSP00000503911|ensembl:ENSP00000503943|ensembl:ENSP00000504101|ensembl:ENSP00000504159|ensembl:ENSP00000504316|ensembl:ENSP00000504361|ensembl:ENSP00000504371|ensembl:ENSP00000504496|ensembl:ENSP00000504523|ensembl:ENSP00000504585|ensembl:ENSP00000504698|ensembl:ENSP00000503504|uniprotkb:A8K6X1 intact:EBI-347978|intact:EBI-28983799|ensembl:ENSP00000305503|ensembl:ENSP00000407331|ensembl:ENSP00000471191|ensembl:ENSP00000473192|uniprotkb:Q6GTM2|uniprotkb:Q503A4|uniprotkb:Q96C43|uniprotkb:Q9NSL1|uniprotkb:B3KWU5 psi-mi:g3bp2_human(display_long)|uniprotkb:GAP SH3 domain-binding protein 2(gene name synonym)|uniprotkb:G3BP2(gene name)|psi-mi:G3BP2(display_short)|uniprotkb:KIAA0660(gene name synonym) psi-mi:nup62_human(display_long)|uniprotkb:NUP62(gene name)|psi-mi:NUP62(display_short)|uniprotkb:62 kDa nucleoporin(gene name synonym)|uniprotkb:Nucleoporin Nup62(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514381|imex:IM-12079-40 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_036429.2|refseq:NP_987100.1|refseq:NP_987101.1|ensembl:ENSG00000138757(gene)|ensembl:ENST00000677620(transcript)|ensembl:ENST00000678062(transcript)|ensembl:ENST00000678100(transcript)|ensembl:ENST00000678123(transcript)|ensembl:ENST00000678265(transcript)|ensembl:ENST00000678578(transcript)|ensembl:ENST00000678798(transcript)|ensembl:ENST00000678971(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007253"(cytoplasmic sequestering of NF-kappaB)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0034063"(stress granule assembly)|go:"GO:0045087"(innate immune response)|go:"GO:0051028"(mRNA transport)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0062029"(positive regulation of stress granule assembly)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR002075(Nuclear transport factor 2)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR018222|interpro:IPR032710|interpro:IPR034376|interpro:IPR034377|interpro:IPR035979|interpro:IPR039539|mint:Q9UN86|rcsb pdb:5DRV|ensembl:ENST00000359707(transcript)|ensembl:ENST00000395719(transcript)|ensembl:ENST00000676584(transcript)|ensembl:ENST00000676974(transcript)|ensembl:ENST00000677162(transcript)|ensembl:ENST00000677171(transcript)|ensembl:ENST00000677201(transcript)|ensembl:ENST00000677333(transcript)|ensembl:ENST00000677566(transcript)|ensembl:ENST00000677606(transcript)|refseq:XP_011530743.1|refseq:XP_005263439.1|refseq:XP_005263440.1|refseq:XP_016864365.1|refseq:XP_016864366.1|refseq:XP_016864367.1|refseq:XP_016864368.1|dip:DIP-50299N refseq:NP_714941.1|ensembl:ENSG00000213024(gene)|ensembl:ENST00000352066(transcript)|ensembl:ENST00000422090(transcript)|ensembl:ENST00000596217(transcript)|ensembl:ENST00000597029(transcript)|go:"GO:0000922"(spindle pole)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005642"(annulate lamellae)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0006405"(RNA export from nucleus)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007100"(mitotic centrosome separation)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007569"(cell aging)|go:"GO:0008219"(cell death)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0003682"(chromatin binding)|go:"GO:0017056"(structural constituent of nuclear pore)|go:"GO:0019894"(kinesin binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042306"(regulation of protein import into nucleus)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043069"(negative regulation of programmed cell death)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0044613"(nuclear pore central transport channel)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046578"(regulation of Ras protein signal transduction)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0046601"(positive regulation of centriole replication)|go:"GO:0051028"(mRNA transport)|go:"GO:0051425"(PTB domain binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060236"(regulation of mitotic spindle organization)|go:"GO:0072686"(mitotic spindle)|reactome:R-HSA-3371453|reactome:R-HSA-4085377|reactome:R-HSA-4551638|reactome:R-HSA-4570464|reactome:R-HSA-4615885|reactome:R-HSA-5578749|reactome:R-HSA-5619107|reactome:R-HSA-6784531|reactome:R-HSA-9609690|reactome:R-HSA-9610379|reactome:R-HSA-9615933|go:"GO:0090543"(Flemming body)|go:"GO:0098534"(centriole assembly)|go:"GO:1903438"(positive regulation of mitotic cytokinetic process)|go:"GO:1904781"(positive regulation of protein localization to centrosome)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR007758(Nucleoporin, Nsp1-like, C-terminal)|interpro:IPR026010|interpro:IPR033072|mint:P37198|rcsb pdb:2H4D|rcsb pdb:5IJN|rcsb pdb:5IJO|reactome:R-HSA-1169408|reactome:R-HSA-159227|reactome:R-HSA-159230|reactome:R-HSA-159231|reactome:R-HSA-159236|reactome:R-HSA-165054|reactome:R-HSA-168271|reactome:R-HSA-168276|reactome:R-HSA-168325|reactome:R-HSA-168333|reactome:R-HSA-170822|reactome:R-HSA-180746|reactome:R-HSA-180910|reactome:R-HSA-191859|reactome:R-HSA-3108214|reactome:R-HSA-3232142|reactome:R-HSA-3301854|refseq:NP_714940.1|refseq:NP_001180286.1|refseq:NP_036478.2|refseq:NP_057637.2|ensembl:ENSP00000305503|ensembl:ENSP00000407331|ensembl:ENSP00000471191|ensembl:ENSP00000473192|dip:DIP-29749N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:bYP8U2wviIqJBWcnLQnuoV0MhV89606 rogid:v7mvKvTtVEnLMwcpUZIcdAzge009606 intact-crc:B0F3248A2A41773A|rigid:0TNucBI9yYzg+HXsmwovpmYCTDM false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UN86 uniprotkb:Q6P5R6 intact:EBI-1044298|uniprotkb:O60606|uniprotkb:O75149|uniprotkb:Q9UPA1|ensembl:ENSP00000352738|ensembl:ENSP00000379069|ensembl:ENSP00000503228|ensembl:ENSP00000503239|ensembl:ENSP00000503355|ensembl:ENSP00000503669|ensembl:ENSP00000503911|ensembl:ENSP00000503943|ensembl:ENSP00000504101|ensembl:ENSP00000504159|ensembl:ENSP00000504316|ensembl:ENSP00000504361|ensembl:ENSP00000504371|ensembl:ENSP00000504496|ensembl:ENSP00000504523|ensembl:ENSP00000504585|ensembl:ENSP00000504698|ensembl:ENSP00000503504|uniprotkb:A8K6X1 intact:EBI-2512545|ensembl:ENSP00000346080|uniprotkb:Q32Q77 psi-mi:g3bp2_human(display_long)|uniprotkb:GAP SH3 domain-binding protein 2(gene name synonym)|uniprotkb:G3BP2(gene name)|psi-mi:G3BP2(display_short)|uniprotkb:KIAA0660(gene name synonym) psi-mi:rl22l_human(display_long)|uniprotkb:RPL22L1(gene name)|psi-mi:RPL22L1(display_short)|uniprotkb:Large ribosomal subunit protein eL22-like 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514381|imex:IM-12079-40 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_036429.2|refseq:NP_987100.1|refseq:NP_987101.1|ensembl:ENSG00000138757(gene)|ensembl:ENST00000677620(transcript)|ensembl:ENST00000678062(transcript)|ensembl:ENST00000678100(transcript)|ensembl:ENST00000678123(transcript)|ensembl:ENST00000678265(transcript)|ensembl:ENST00000678578(transcript)|ensembl:ENST00000678798(transcript)|ensembl:ENST00000678971(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007253"(cytoplasmic sequestering of NF-kappaB)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0034063"(stress granule assembly)|go:"GO:0045087"(innate immune response)|go:"GO:0051028"(mRNA transport)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0062029"(positive regulation of stress granule assembly)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR002075(Nuclear transport factor 2)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR018222|interpro:IPR032710|interpro:IPR034376|interpro:IPR034377|interpro:IPR035979|interpro:IPR039539|mint:Q9UN86|rcsb pdb:5DRV|ensembl:ENST00000359707(transcript)|ensembl:ENST00000395719(transcript)|ensembl:ENST00000676584(transcript)|ensembl:ENST00000676974(transcript)|ensembl:ENST00000677162(transcript)|ensembl:ENST00000677171(transcript)|ensembl:ENST00000677201(transcript)|ensembl:ENST00000677333(transcript)|ensembl:ENST00000677566(transcript)|ensembl:ENST00000677606(transcript)|refseq:XP_011530743.1|refseq:XP_005263439.1|refseq:XP_005263440.1|refseq:XP_016864365.1|refseq:XP_016864366.1|refseq:XP_016864367.1|refseq:XP_016864368.1|dip:DIP-50299N ensembl:ENSG00000163584(gene)|ensembl:ENST00000295830(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005840"(ribosome)|interpro:IPR002671(Ribosomal protein L22e)|interpro:IPR028370|interpro:IPR038526|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|refseq:NP_001093115.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:bYP8U2wviIqJBWcnLQnuoV0MhV89606 rogid:F0hKX3isBeCP4gGQNBrar7f5YUw9606 intact-crc:B0F3248A2A41773A|rigid:0TNucBI9yYzg+HXsmwovpmYCTDM false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UN86 uniprotkb:P13489 intact:EBI-1044298|uniprotkb:O60606|uniprotkb:O75149|uniprotkb:Q9UPA1|ensembl:ENSP00000352738|ensembl:ENSP00000379069|ensembl:ENSP00000503228|ensembl:ENSP00000503239|ensembl:ENSP00000503355|ensembl:ENSP00000503669|ensembl:ENSP00000503911|ensembl:ENSP00000503943|ensembl:ENSP00000504101|ensembl:ENSP00000504159|ensembl:ENSP00000504316|ensembl:ENSP00000504361|ensembl:ENSP00000504371|ensembl:ENSP00000504496|ensembl:ENSP00000504523|ensembl:ENSP00000504585|ensembl:ENSP00000504698|ensembl:ENSP00000503504|uniprotkb:A8K6X1 intact:EBI-1237106|uniprotkb:Q8IZK8|uniprotkb:Q96FD7|uniprotkb:Q9BQ80|uniprotkb:Q9UDK6|ensembl:ENSP00000346402|ensembl:ENSP00000348515|ensembl:ENSP00000380729|ensembl:ENSP00000380738|ensembl:ENSP00000380739|ensembl:ENSP00000416589|ensembl:ENSP00000433999|ensembl:ENSP00000435594|ensembl:ENSP00000478664|ensembl:ENSP00000479004|ensembl:ENSP00000479966|ensembl:ENSP00000480036|ensembl:ENSP00000484572|ensembl:ENSP00000487753|ensembl:ENSP00000487940|ensembl:ENSP00000488734 psi-mi:g3bp2_human(display_long)|uniprotkb:GAP SH3 domain-binding protein 2(gene name synonym)|uniprotkb:G3BP2(gene name)|psi-mi:G3BP2(display_short)|uniprotkb:KIAA0660(gene name synonym) psi-mi:rini_human(display_long)|uniprotkb:RNH1(gene name)|psi-mi:RNH1(display_short)|uniprotkb:PRI(gene name synonym)|uniprotkb:RNH(gene name synonym)|uniprotkb:Ribonuclease/angiogenin inhibitor 1(gene name synonym)|uniprotkb:Placental ribonuclease inhibitor(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514381|imex:IM-12079-40 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_036429.2|refseq:NP_987100.1|refseq:NP_987101.1|ensembl:ENSG00000138757(gene)|ensembl:ENST00000677620(transcript)|ensembl:ENST00000678062(transcript)|ensembl:ENST00000678100(transcript)|ensembl:ENST00000678123(transcript)|ensembl:ENST00000678265(transcript)|ensembl:ENST00000678578(transcript)|ensembl:ENST00000678798(transcript)|ensembl:ENST00000678971(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007253"(cytoplasmic sequestering of NF-kappaB)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0034063"(stress granule assembly)|go:"GO:0045087"(innate immune response)|go:"GO:0051028"(mRNA transport)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0062029"(positive regulation of stress granule assembly)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR002075(Nuclear transport factor 2)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR018222|interpro:IPR032710|interpro:IPR034376|interpro:IPR034377|interpro:IPR035979|interpro:IPR039539|mint:Q9UN86|rcsb pdb:5DRV|ensembl:ENST00000359707(transcript)|ensembl:ENST00000395719(transcript)|ensembl:ENST00000676584(transcript)|ensembl:ENST00000676974(transcript)|ensembl:ENST00000677162(transcript)|ensembl:ENST00000677171(transcript)|ensembl:ENST00000677201(transcript)|ensembl:ENST00000677333(transcript)|ensembl:ENST00000677566(transcript)|ensembl:ENST00000677606(transcript)|refseq:XP_011530743.1|refseq:XP_005263439.1|refseq:XP_005263440.1|refseq:XP_016864365.1|refseq:XP_016864366.1|refseq:XP_016864367.1|refseq:XP_016864368.1|dip:DIP-50299N refseq:NP_002930.2|refseq:NP_976317.1|refseq:NP_976318.1|refseq:NP_976319.1|refseq:NP_976320.1|refseq:NP_976321.1|refseq:NP_976322.1|refseq:NP_976323.1|refseq:XP_011518557.1|refseq:XP_011518559.1|refseq:XP_011518560.1|refseq:XP_011518561.1|refseq:XP_011518562.1|refseq:XP_011518563.1|refseq:XP_011518564.1|refseq:XP_011518565.1|refseq:XP_016873595.1|ensembl:ENST00000619599(transcript)|ensembl:ENST00000621211(transcript)|ensembl:ENST00000632527(transcript)|ensembl:ENST00000632954(transcript)|ensembl:ENST00000633287(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006402"(mRNA catabolic process)|go:"GO:0008428"(ribonuclease inhibitor activity)|go:"GO:0032311"(angiogenin-PRI complex)|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR006553(Leucine-rich repeat, cysteine-containing subtype)|interpro:IPR032675|interpro:IPR041302|mint:P13489|rcsb pdb:1A4Y|rcsb pdb:1Z7X|rcsb pdb:2BEX|rcsb pdb:2Q4G|ensembl:ENSG00000023191(gene)|ensembl:ENSG00000276230(gene)|ensembl:ENST00000354420(transcript)|ensembl:ENST00000356187(transcript)|ensembl:ENST00000397604(transcript)|ensembl:ENST00000397614(transcript)|ensembl:ENST00000397615(transcript)|ensembl:ENST00000438658(transcript)|ensembl:ENST00000533410(transcript)|ensembl:ENST00000534797(transcript)|ensembl:ENST00000612988(transcript)|ensembl:ENST00000617351(transcript)|ensembl:ENST00000618184(transcript) psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:bYP8U2wviIqJBWcnLQnuoV0MhV89606 rogid:1WMWoYulk8Aj8HYhDcqnauddUFk9606 intact-crc:B0F3248A2A41773A|rigid:0TNucBI9yYzg+HXsmwovpmYCTDM false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UN86 uniprotkb:Q7Z417 intact:EBI-1044298|uniprotkb:O60606|uniprotkb:O75149|uniprotkb:Q9UPA1|ensembl:ENSP00000352738|ensembl:ENSP00000379069|ensembl:ENSP00000503228|ensembl:ENSP00000503239|ensembl:ENSP00000503355|ensembl:ENSP00000503669|ensembl:ENSP00000503911|ensembl:ENSP00000503943|ensembl:ENSP00000504101|ensembl:ENSP00000504159|ensembl:ENSP00000504316|ensembl:ENSP00000504361|ensembl:ENSP00000504371|ensembl:ENSP00000504496|ensembl:ENSP00000504523|ensembl:ENSP00000504585|ensembl:ENSP00000504698|ensembl:ENSP00000503504|uniprotkb:A8K6X1 intact:EBI-1210753|intact:EBI-10172018|uniprotkb:A1L3A7|uniprotkb:Q9P2M5|uniprotkb:A1L3A6|ensembl:ENSP00000225388 psi-mi:g3bp2_human(display_long)|uniprotkb:GAP SH3 domain-binding protein 2(gene name synonym)|uniprotkb:G3BP2(gene name)|psi-mi:G3BP2(display_short)|uniprotkb:KIAA0660(gene name synonym) psi-mi:nufp2_human(display_long)|uniprotkb:NUFIP2(gene name)|psi-mi:NUFIP2(display_short)|uniprotkb:KIAA1321(gene name synonym)|uniprotkb:PIG1(orf name)|uniprotkb:FMRP-interacting protein 2(gene name synonym)|uniprotkb:82 kDa FMRP-interacting protein(gene name synonym)|uniprotkb:Cell proliferation-inducing gene 1 protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514381|imex:IM-12079-40 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_036429.2|refseq:NP_987100.1|refseq:NP_987101.1|ensembl:ENSG00000138757(gene)|ensembl:ENST00000677620(transcript)|ensembl:ENST00000678062(transcript)|ensembl:ENST00000678100(transcript)|ensembl:ENST00000678123(transcript)|ensembl:ENST00000678265(transcript)|ensembl:ENST00000678578(transcript)|ensembl:ENST00000678798(transcript)|ensembl:ENST00000678971(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007253"(cytoplasmic sequestering of NF-kappaB)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0034063"(stress granule assembly)|go:"GO:0045087"(innate immune response)|go:"GO:0051028"(mRNA transport)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0062029"(positive regulation of stress granule assembly)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR002075(Nuclear transport factor 2)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR018222|interpro:IPR032710|interpro:IPR034376|interpro:IPR034377|interpro:IPR035979|interpro:IPR039539|mint:Q9UN86|rcsb pdb:5DRV|ensembl:ENST00000359707(transcript)|ensembl:ENST00000395719(transcript)|ensembl:ENST00000676584(transcript)|ensembl:ENST00000676974(transcript)|ensembl:ENST00000677162(transcript)|ensembl:ENST00000677171(transcript)|ensembl:ENST00000677201(transcript)|ensembl:ENST00000677333(transcript)|ensembl:ENST00000677566(transcript)|ensembl:ENST00000677606(transcript)|refseq:XP_011530743.1|refseq:XP_005263439.1|refseq:XP_005263440.1|refseq:XP_016864365.1|refseq:XP_016864366.1|refseq:XP_016864367.1|refseq:XP_016864368.1|dip:DIP-50299N refseq:NP_065823.1|dip:DIP-29023N|ensembl:ENSG00000108256(gene)|ensembl:ENST00000225388(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0042788"(polysomal ribosome)|interpro:IPR032747|mint:Q7Z417 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:bYP8U2wviIqJBWcnLQnuoV0MhV89606 rogid:zdbkRisveP+8g70umfbEPHTnAgk9606 intact-crc:B0F3248A2A41773A|rigid:0TNucBI9yYzg+HXsmwovpmYCTDM false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UN86 uniprotkb:Q9GZR7 intact:EBI-1044298|uniprotkb:O60606|uniprotkb:O75149|uniprotkb:Q9UPA1|ensembl:ENSP00000352738|ensembl:ENSP00000379069|ensembl:ENSP00000503228|ensembl:ENSP00000503239|ensembl:ENSP00000503355|ensembl:ENSP00000503669|ensembl:ENSP00000503911|ensembl:ENSP00000503943|ensembl:ENSP00000504101|ensembl:ENSP00000504159|ensembl:ENSP00000504316|ensembl:ENSP00000504361|ensembl:ENSP00000504371|ensembl:ENSP00000504496|ensembl:ENSP00000504523|ensembl:ENSP00000504585|ensembl:ENSP00000504698|ensembl:ENSP00000503504|uniprotkb:A8K6X1 intact:EBI-713081|ensembl:ENSP00000481495|ensembl:ENSP00000482106|uniprotkb:E7EMJ4|uniprotkb:Q4V9L5 psi-mi:g3bp2_human(display_long)|uniprotkb:GAP SH3 domain-binding protein 2(gene name synonym)|uniprotkb:G3BP2(gene name)|psi-mi:G3BP2(display_short)|uniprotkb:KIAA0660(gene name synonym) psi-mi:ddx24_human(display_long)|uniprotkb:DEAD box protein 24(gene name synonym)|uniprotkb:DDX24(gene name)|psi-mi:DDX24(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514381|imex:IM-12079-40 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_036429.2|refseq:NP_987100.1|refseq:NP_987101.1|ensembl:ENSG00000138757(gene)|ensembl:ENST00000677620(transcript)|ensembl:ENST00000678062(transcript)|ensembl:ENST00000678100(transcript)|ensembl:ENST00000678123(transcript)|ensembl:ENST00000678265(transcript)|ensembl:ENST00000678578(transcript)|ensembl:ENST00000678798(transcript)|ensembl:ENST00000678971(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007253"(cytoplasmic sequestering of NF-kappaB)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0034063"(stress granule assembly)|go:"GO:0045087"(innate immune response)|go:"GO:0051028"(mRNA transport)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0062029"(positive regulation of stress granule assembly)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR002075(Nuclear transport factor 2)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR018222|interpro:IPR032710|interpro:IPR034376|interpro:IPR034377|interpro:IPR035979|interpro:IPR039539|mint:Q9UN86|rcsb pdb:5DRV|ensembl:ENST00000359707(transcript)|ensembl:ENST00000395719(transcript)|ensembl:ENST00000676584(transcript)|ensembl:ENST00000676974(transcript)|ensembl:ENST00000677162(transcript)|ensembl:ENST00000677171(transcript)|ensembl:ENST00000677201(transcript)|ensembl:ENST00000677333(transcript)|ensembl:ENST00000677566(transcript)|ensembl:ENST00000677606(transcript)|refseq:XP_011530743.1|refseq:XP_005263439.1|refseq:XP_005263440.1|refseq:XP_016864365.1|refseq:XP_016864366.1|refseq:XP_016864367.1|refseq:XP_016864368.1|dip:DIP-50299N ensembl:ENSG00000089737(gene)|ensembl:ENSG00000273761(gene)|ensembl:ENST00000613280(transcript)|ensembl:ENST00000621632(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005730"(nucleolus)|go:"GO:0016020"(membrane)|go:"GO:0016070"(RNA metabolic process)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR000629(RNA helicase, ATP-dependent, DEAD-box, conserved site)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR027417|mint:Q9GZR7|refseq:NP_065147.1|dip:DIP-47301N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:bYP8U2wviIqJBWcnLQnuoV0MhV89606 rogid:n9gQabTC50Y/LtGMAMFNVgj12as9606 intact-crc:B0F3248A2A41773A|rigid:0TNucBI9yYzg+HXsmwovpmYCTDM false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UN86 uniprotkb:O95363 intact:EBI-1044298|uniprotkb:O60606|uniprotkb:O75149|uniprotkb:Q9UPA1|ensembl:ENSP00000352738|ensembl:ENSP00000379069|ensembl:ENSP00000503228|ensembl:ENSP00000503239|ensembl:ENSP00000503355|ensembl:ENSP00000503669|ensembl:ENSP00000503911|ensembl:ENSP00000503943|ensembl:ENSP00000504101|ensembl:ENSP00000504159|ensembl:ENSP00000504316|ensembl:ENSP00000504361|ensembl:ENSP00000504371|ensembl:ENSP00000504496|ensembl:ENSP00000504523|ensembl:ENSP00000504585|ensembl:ENSP00000504698|ensembl:ENSP00000503504|uniprotkb:A8K6X1 intact:EBI-2513774|ensembl:ENSP00000274680|ensembl:ENSP00000316335|uniprotkb:B2R664|uniprotkb:Q6FG29|uniprotkb:Q9NPY7|uniprotkb:Q9P062|uniprotkb:Q53F66|uniprotkb:Q5TCS3 psi-mi:g3bp2_human(display_long)|uniprotkb:GAP SH3 domain-binding protein 2(gene name synonym)|uniprotkb:G3BP2(gene name)|psi-mi:G3BP2(display_short)|uniprotkb:KIAA0660(gene name synonym) psi-mi:syfm_human(display_long)|uniprotkb:FARS2(gene name)|psi-mi:FARS2(display_short)|uniprotkb:FARS1(gene name synonym)|uniprotkb:Phenylalanyl-tRNA synthetase(gene name synonym)|uniprotkb:HSPC320(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514381|imex:IM-12079-40 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_036429.2|refseq:NP_987100.1|refseq:NP_987101.1|ensembl:ENSG00000138757(gene)|ensembl:ENST00000677620(transcript)|ensembl:ENST00000678062(transcript)|ensembl:ENST00000678100(transcript)|ensembl:ENST00000678123(transcript)|ensembl:ENST00000678265(transcript)|ensembl:ENST00000678578(transcript)|ensembl:ENST00000678798(transcript)|ensembl:ENST00000678971(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007253"(cytoplasmic sequestering of NF-kappaB)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0034063"(stress granule assembly)|go:"GO:0045087"(innate immune response)|go:"GO:0051028"(mRNA transport)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0062029"(positive regulation of stress granule assembly)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR002075(Nuclear transport factor 2)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR018222|interpro:IPR032710|interpro:IPR034376|interpro:IPR034377|interpro:IPR035979|interpro:IPR039539|mint:Q9UN86|rcsb pdb:5DRV|ensembl:ENST00000359707(transcript)|ensembl:ENST00000395719(transcript)|ensembl:ENST00000676584(transcript)|ensembl:ENST00000676974(transcript)|ensembl:ENST00000677162(transcript)|ensembl:ENST00000677171(transcript)|ensembl:ENST00000677201(transcript)|ensembl:ENST00000677333(transcript)|ensembl:ENST00000677566(transcript)|ensembl:ENST00000677606(transcript)|refseq:XP_011530743.1|refseq:XP_005263439.1|refseq:XP_005263440.1|refseq:XP_016864365.1|refseq:XP_016864366.1|refseq:XP_016864367.1|refseq:XP_016864368.1|dip:DIP-50299N ensembl:ENSG00000145982(gene)|ensembl:ENST00000274680(transcript)|ensembl:ENST00000324331(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0004826"(phenylalanine-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006418"(tRNA aminoacylation for protein translation)|go:"GO:0006432"(phenylalanyl-tRNA aminoacylation)|go:"GO:0008033"(tRNA processing)|interpro:IPR002319(Phenylalanyl-tRNA synthetase, class IIc)|interpro:IPR004530(Phenylalanyl-tRNA synthetase, class IIc, mitochondrial)|interpro:IPR005121(Phenylalanyl-tRNA synthetase, beta subunit, ferrodoxin-fold anticodon-binding)|interpro:IPR006195(Aminoacyl-tRNA synthetase, class II)|interpro:IPR036690|rcsb pdb:3CMQ|rcsb pdb:3HFV|rcsb pdb:3TEG|rcsb pdb:3TUP|rcsb pdb:5MGH|rcsb pdb:5MGU|rcsb pdb:5MGV|rcsb pdb:5MGW|reactome:R-HSA-379726|refseq:NP_001305801.1|refseq:NP_006558.1|refseq:XP_016865675.1|refseq:XP_016865676.1|refseq:XP_005248869.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:bYP8U2wviIqJBWcnLQnuoV0MhV89606 rogid:bClmsDMPN2mEiOKnN8nuhlWpwQc9606 intact-crc:B0F3248A2A41773A|rigid:0TNucBI9yYzg+HXsmwovpmYCTDM false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UN86 uniprotkb:Q9H7B2 intact:EBI-1044298|uniprotkb:O60606|uniprotkb:O75149|uniprotkb:Q9UPA1|ensembl:ENSP00000352738|ensembl:ENSP00000379069|ensembl:ENSP00000503228|ensembl:ENSP00000503239|ensembl:ENSP00000503355|ensembl:ENSP00000503669|ensembl:ENSP00000503911|ensembl:ENSP00000503943|ensembl:ENSP00000504101|ensembl:ENSP00000504159|ensembl:ENSP00000504316|ensembl:ENSP00000504361|ensembl:ENSP00000504371|ensembl:ENSP00000504496|ensembl:ENSP00000504523|ensembl:ENSP00000504585|ensembl:ENSP00000504698|ensembl:ENSP00000503504|uniprotkb:A8K6X1 intact:EBI-1051960|uniprotkb:Q8N4A1|uniprotkb:Q5VXN1|ensembl:ENSP00000402338 psi-mi:g3bp2_human(display_long)|uniprotkb:GAP SH3 domain-binding protein 2(gene name synonym)|uniprotkb:G3BP2(gene name)|psi-mi:G3BP2(display_short)|uniprotkb:KIAA0660(gene name synonym) psi-mi:rpf2_human(display_long)|uniprotkb:RPF2(gene name)|psi-mi:RPF2(display_short)|uniprotkb:BXDC1(gene name synonym)|uniprotkb:Ribosome biogenesis protein RPF2 homolog(gene name synonym)|uniprotkb:Brix domain-containing protein 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514381|imex:IM-12079-40 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_036429.2|refseq:NP_987100.1|refseq:NP_987101.1|ensembl:ENSG00000138757(gene)|ensembl:ENST00000677620(transcript)|ensembl:ENST00000678062(transcript)|ensembl:ENST00000678100(transcript)|ensembl:ENST00000678123(transcript)|ensembl:ENST00000678265(transcript)|ensembl:ENST00000678578(transcript)|ensembl:ENST00000678798(transcript)|ensembl:ENST00000678971(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007253"(cytoplasmic sequestering of NF-kappaB)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0034063"(stress granule assembly)|go:"GO:0045087"(innate immune response)|go:"GO:0051028"(mRNA transport)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0062029"(positive regulation of stress granule assembly)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR002075(Nuclear transport factor 2)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR018222|interpro:IPR032710|interpro:IPR034376|interpro:IPR034377|interpro:IPR035979|interpro:IPR039539|mint:Q9UN86|rcsb pdb:5DRV|ensembl:ENST00000359707(transcript)|ensembl:ENST00000395719(transcript)|ensembl:ENST00000676584(transcript)|ensembl:ENST00000676974(transcript)|ensembl:ENST00000677162(transcript)|ensembl:ENST00000677171(transcript)|ensembl:ENST00000677201(transcript)|ensembl:ENST00000677333(transcript)|ensembl:ENST00000677566(transcript)|ensembl:ENST00000677606(transcript)|refseq:XP_011530743.1|refseq:XP_005263439.1|refseq:XP_005263440.1|refseq:XP_016864365.1|refseq:XP_016864366.1|refseq:XP_016864367.1|refseq:XP_016864368.1|dip:DIP-50299N refseq:NP_115570.1|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0008097"(5S rRNA binding)|go:"GO:0019843"(rRNA binding)|go:"GO:0042273"(ribosomal large subunit biogenesis)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1902570"(protein localization to nucleolus)|interpro:IPR007109(Brix)|interpro:IPR039770|mint:Q9H7B2|ensembl:ENSG00000197498(gene)|ensembl:ENST00000441448(transcript)|go:"GO:0000027"(ribosomal large subunit assembly)|go:"GO:0000463"("maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)") psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:bYP8U2wviIqJBWcnLQnuoV0MhV89606 rogid:CXU4CHQmcrISLS8GDIwEMGhiaQI9606 intact-crc:B0F3248A2A41773A|rigid:0TNucBI9yYzg+HXsmwovpmYCTDM false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UN86 uniprotkb:Q14694 intact:EBI-1044298|uniprotkb:O60606|uniprotkb:O75149|uniprotkb:Q9UPA1|ensembl:ENSP00000352738|ensembl:ENSP00000379069|ensembl:ENSP00000503228|ensembl:ENSP00000503239|ensembl:ENSP00000503355|ensembl:ENSP00000503669|ensembl:ENSP00000503911|ensembl:ENSP00000503943|ensembl:ENSP00000504101|ensembl:ENSP00000504159|ensembl:ENSP00000504316|ensembl:ENSP00000504361|ensembl:ENSP00000504371|ensembl:ENSP00000504496|ensembl:ENSP00000504523|ensembl:ENSP00000504585|ensembl:ENSP00000504698|ensembl:ENSP00000503504|uniprotkb:A8K6X1 intact:EBI-2510389|uniprotkb:B4DS84|uniprotkb:B2RDJ8|uniprotkb:Q9BWG7|uniprotkb:Q9NSL7|ensembl:ENSP00000219473 psi-mi:g3bp2_human(display_long)|uniprotkb:GAP SH3 domain-binding protein 2(gene name synonym)|uniprotkb:G3BP2(gene name)|psi-mi:G3BP2(display_short)|uniprotkb:KIAA0660(gene name synonym) psi-mi:ubp10_human(display_long)|uniprotkb:USP10(gene name)|psi-mi:USP10(display_short)|uniprotkb:KIAA0190(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 10(gene name synonym)|uniprotkb:Deubiquitinating enzyme 10(gene name synonym)|uniprotkb:Ubiquitin thioesterase 10(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514381|imex:IM-12079-40 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_036429.2|refseq:NP_987100.1|refseq:NP_987101.1|ensembl:ENSG00000138757(gene)|ensembl:ENST00000677620(transcript)|ensembl:ENST00000678062(transcript)|ensembl:ENST00000678100(transcript)|ensembl:ENST00000678123(transcript)|ensembl:ENST00000678265(transcript)|ensembl:ENST00000678578(transcript)|ensembl:ENST00000678798(transcript)|ensembl:ENST00000678971(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007253"(cytoplasmic sequestering of NF-kappaB)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0034063"(stress granule assembly)|go:"GO:0045087"(innate immune response)|go:"GO:0051028"(mRNA transport)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0062029"(positive regulation of stress granule assembly)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR002075(Nuclear transport factor 2)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR018222|interpro:IPR032710|interpro:IPR034376|interpro:IPR034377|interpro:IPR035979|interpro:IPR039539|mint:Q9UN86|rcsb pdb:5DRV|ensembl:ENST00000359707(transcript)|ensembl:ENST00000395719(transcript)|ensembl:ENST00000676584(transcript)|ensembl:ENST00000676974(transcript)|ensembl:ENST00000677162(transcript)|ensembl:ENST00000677171(transcript)|ensembl:ENST00000677201(transcript)|ensembl:ENST00000677333(transcript)|ensembl:ENST00000677566(transcript)|ensembl:ENST00000677606(transcript)|refseq:XP_011530743.1|refseq:XP_005263439.1|refseq:XP_005263440.1|refseq:XP_016864365.1|refseq:XP_016864366.1|refseq:XP_016864367.1|refseq:XP_016864368.1|dip:DIP-50299N refseq:NP_005144.2|ensembl:ENSP00000219473|ensembl:ENST00000570191|ensembl:ENSP00000457411|refseq:NP_001259004.1|ensembl:ENSG00000103194(gene)|ensembl:ENST00000219473(transcript)|go:"GO:0002039"(p53 binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006914"(autophagy)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019985"(translesion synthesis)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0071347"(cellular response to interleukin-1)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR009818(Ataxin-2, C-terminal)|interpro:IPR018200|interpro:IPR028767|interpro:IPR028889|interpro:IPR038765|mint:Q14694|reactome:R-HSA-5656169|reactome:R-HSA-5689880|go:"GO:0005737"(cytoplasm) psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:bYP8U2wviIqJBWcnLQnuoV0MhV89606 rogid:W34ZdOIilLOVI8SXqCH3rOmmloo9606 intact-crc:B0F3248A2A41773A|rigid:0TNucBI9yYzg+HXsmwovpmYCTDM false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UN86 uniprotkb:Q5T6F2 intact:EBI-1044298|uniprotkb:O60606|uniprotkb:O75149|uniprotkb:Q9UPA1|ensembl:ENSP00000352738|ensembl:ENSP00000379069|ensembl:ENSP00000503228|ensembl:ENSP00000503239|ensembl:ENSP00000503355|ensembl:ENSP00000503669|ensembl:ENSP00000503911|ensembl:ENSP00000503943|ensembl:ENSP00000504101|ensembl:ENSP00000504159|ensembl:ENSP00000504316|ensembl:ENSP00000504361|ensembl:ENSP00000504371|ensembl:ENSP00000504496|ensembl:ENSP00000504523|ensembl:ENSP00000504585|ensembl:ENSP00000504698|ensembl:ENSP00000503504|uniprotkb:A8K6X1 intact:EBI-2514383|ensembl:ENSP00000368540|ensembl:ENSP00000507293|ensembl:ENSP00000508372|uniprotkb:Q5JV03|uniprotkb:Q9P237|uniprotkb:Q8NC94|uniprotkb:Q6PK34|uniprotkb:Q2M2R4 psi-mi:g3bp2_human(display_long)|uniprotkb:GAP SH3 domain-binding protein 2(gene name synonym)|uniprotkb:G3BP2(gene name)|psi-mi:G3BP2(display_short)|uniprotkb:KIAA0660(gene name synonym) psi-mi:ubap2_human(display_long)|uniprotkb:UBAP2(gene name)|psi-mi:UBAP2(display_short)|uniprotkb:KIAA1491(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514381|imex:IM-12079-40 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_036429.2|refseq:NP_987100.1|refseq:NP_987101.1|ensembl:ENSG00000138757(gene)|ensembl:ENST00000677620(transcript)|ensembl:ENST00000678062(transcript)|ensembl:ENST00000678100(transcript)|ensembl:ENST00000678123(transcript)|ensembl:ENST00000678265(transcript)|ensembl:ENST00000678578(transcript)|ensembl:ENST00000678798(transcript)|ensembl:ENST00000678971(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007253"(cytoplasmic sequestering of NF-kappaB)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0034063"(stress granule assembly)|go:"GO:0045087"(innate immune response)|go:"GO:0051028"(mRNA transport)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0062029"(positive regulation of stress granule assembly)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR002075(Nuclear transport factor 2)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR018222|interpro:IPR032710|interpro:IPR034376|interpro:IPR034377|interpro:IPR035979|interpro:IPR039539|mint:Q9UN86|rcsb pdb:5DRV|ensembl:ENST00000359707(transcript)|ensembl:ENST00000395719(transcript)|ensembl:ENST00000676584(transcript)|ensembl:ENST00000676974(transcript)|ensembl:ENST00000677162(transcript)|ensembl:ENST00000677171(transcript)|ensembl:ENST00000677201(transcript)|ensembl:ENST00000677333(transcript)|ensembl:ENST00000677566(transcript)|ensembl:ENST00000677606(transcript)|refseq:XP_011530743.1|refseq:XP_005263439.1|refseq:XP_005263440.1|refseq:XP_016864365.1|refseq:XP_016864366.1|refseq:XP_016864367.1|refseq:XP_016864368.1|dip:DIP-50299N refseq:NP_001269458.1|refseq:NP_060919.3|ensembl:ENSG00000137073(gene)|ensembl:ENST00000379238(transcript)|ensembl:ENST00000682239(transcript)|ensembl:ENST00000684158(transcript)|go:"GO:0000932"(P-body)|go:"GO:0003723"(RNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0045296"(cadherin binding)|go:"GO:0005634"(nucleus)|interpro:IPR009060(UBA-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR022166|refseq:NP_001269459.1|ensembl:ENSP00000368540|ensembl:ENSP00000507293|ensembl:ENSP00000508372 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:bYP8U2wviIqJBWcnLQnuoV0MhV89606 rogid:0bcavAC5MrP55wijYi8LYZbT6ys9606 intact-crc:B0F3248A2A41773A|rigid:0TNucBI9yYzg+HXsmwovpmYCTDM false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UN86 uniprotkb:P35658 intact:EBI-1044298|uniprotkb:O60606|uniprotkb:O75149|uniprotkb:Q9UPA1|ensembl:ENSP00000352738|ensembl:ENSP00000379069|ensembl:ENSP00000503228|ensembl:ENSP00000503239|ensembl:ENSP00000503355|ensembl:ENSP00000503669|ensembl:ENSP00000503911|ensembl:ENSP00000503943|ensembl:ENSP00000504101|ensembl:ENSP00000504159|ensembl:ENSP00000504316|ensembl:ENSP00000504361|ensembl:ENSP00000504371|ensembl:ENSP00000504496|ensembl:ENSP00000504523|ensembl:ENSP00000504585|ensembl:ENSP00000504698|ensembl:ENSP00000503504|uniprotkb:A8K6X1 intact:EBI-1222270|uniprotkb:A6NFQ0|uniprotkb:Q15010|uniprotkb:Q3KQZ0|uniprotkb:Q5JUP7|uniprotkb:Q75R47|uniprotkb:Q86XD3|intact:EBI-2555216|ensembl:ENSP00000352400 psi-mi:g3bp2_human(display_long)|uniprotkb:GAP SH3 domain-binding protein 2(gene name synonym)|uniprotkb:G3BP2(gene name)|psi-mi:G3BP2(display_short)|uniprotkb:KIAA0660(gene name synonym) psi-mi:nu214_human(display_long)|uniprotkb:NUP214(gene name)|psi-mi:NUP214(display_short)|uniprotkb:CAIN(gene name synonym)|uniprotkb:CAN(gene name synonym)|uniprotkb:KIAA0023(gene name synonym)|uniprotkb:Nucleoporin Nup214(gene name synonym)|uniprotkb:214 kDa nucleoporin(gene name synonym)|uniprotkb:Protein CAN(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514381|imex:IM-12079-40 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_036429.2|refseq:NP_987100.1|refseq:NP_987101.1|ensembl:ENSG00000138757(gene)|ensembl:ENST00000677620(transcript)|ensembl:ENST00000678062(transcript)|ensembl:ENST00000678100(transcript)|ensembl:ENST00000678123(transcript)|ensembl:ENST00000678265(transcript)|ensembl:ENST00000678578(transcript)|ensembl:ENST00000678798(transcript)|ensembl:ENST00000678971(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007253"(cytoplasmic sequestering of NF-kappaB)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0034063"(stress granule assembly)|go:"GO:0045087"(innate immune response)|go:"GO:0051028"(mRNA transport)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0062029"(positive regulation of stress granule assembly)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR002075(Nuclear transport factor 2)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR018222|interpro:IPR032710|interpro:IPR034376|interpro:IPR034377|interpro:IPR035979|interpro:IPR039539|mint:Q9UN86|rcsb pdb:5DRV|ensembl:ENST00000359707(transcript)|ensembl:ENST00000395719(transcript)|ensembl:ENST00000676584(transcript)|ensembl:ENST00000676974(transcript)|ensembl:ENST00000677162(transcript)|ensembl:ENST00000677171(transcript)|ensembl:ENST00000677201(transcript)|ensembl:ENST00000677333(transcript)|ensembl:ENST00000677566(transcript)|ensembl:ENST00000677606(transcript)|refseq:XP_011530743.1|refseq:XP_005263439.1|refseq:XP_005263440.1|refseq:XP_016864365.1|refseq:XP_016864366.1|refseq:XP_016864367.1|refseq:XP_016864368.1|dip:DIP-50299N ensembl:ENSP00000352400|ensembl:ENST00000411637|ensembl:ENSP00000396576|refseq:NP_005076.3|refseq:NP_001305253.1|refseq:NP_001305254.1|dip:DIP-38367N|rcsb pdb:3FMP|rcsb pdb:5DIS|reactome:R-HSA-1169408|reactome:R-HSA-159227|reactome:R-HSA-159230|reactome:R-HSA-159231|reactome:R-HSA-159236|reactome:R-HSA-165054|reactome:R-HSA-168271|reactome:R-HSA-168276|reactome:R-HSA-168325|reactome:R-HSA-168333|reactome:R-HSA-170822|reactome:R-HSA-180746|reactome:R-HSA-180910|reactome:R-HSA-191859|reactome:R-HSA-3108214|reactome:R-HSA-3232142|reactome:R-HSA-3301854|reactome:R-HSA-3371453|reactome:R-HSA-4085377|reactome:R-HSA-450520|reactome:R-HSA-4551638|reactome:R-HSA-4570464|reactome:R-HSA-4615885|reactome:R-HSA-5578749|reactome:R-HSA-5619107|reactome:R-HSA-6784531|reactome:R-HSA-9609690|reactome:R-HSA-9610379|rcsb pdb:3FMO|ensembl:ENSG00000126883(gene)|ensembl:ENST00000359428(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005049"(nuclear export signal receptor activity)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006405"(RNA export from nucleus)|go:"GO:0006406"(mRNA export from nucleus)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0017056"(structural constituent of nuclear pore)|go:"GO:0046822"(regulation of nucleocytoplasmic transport)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:1990876"(cytoplasmic side of nuclear pore)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR026054|interpro:IPR041553|mint:P35658|rcsb pdb:2OIT|rcsb pdb:3FHC psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:bYP8U2wviIqJBWcnLQnuoV0MhV89606 rogid:cW7RIiR4uhQgXIaByMiW3niFtTo9606 intact-crc:B0F3248A2A41773A|rigid:0TNucBI9yYzg+HXsmwovpmYCTDM false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UN86 uniprotkb:Q8WWM7 intact:EBI-1044298|uniprotkb:O60606|uniprotkb:O75149|uniprotkb:Q9UPA1|ensembl:ENSP00000352738|ensembl:ENSP00000379069|ensembl:ENSP00000503228|ensembl:ENSP00000503239|ensembl:ENSP00000503355|ensembl:ENSP00000503669|ensembl:ENSP00000503911|ensembl:ENSP00000503943|ensembl:ENSP00000504101|ensembl:ENSP00000504159|ensembl:ENSP00000504316|ensembl:ENSP00000504361|ensembl:ENSP00000504371|ensembl:ENSP00000504496|ensembl:ENSP00000504523|ensembl:ENSP00000504585|ensembl:ENSP00000504698|ensembl:ENSP00000503504|uniprotkb:A8K6X1 intact:EBI-948363|ensembl:ENSP00000338718|uniprotkb:O95135|uniprotkb:Q6NVJ8|uniprotkb:Q6PJW6|uniprotkb:Q8IU61|uniprotkb:Q8IU95|uniprotkb:Q8WWM3|uniprotkb:Q8WWM4|uniprotkb:Q8WWM5|uniprotkb:Q8WWM6|uniprotkb:Q99703|uniprotkb:B9EGM2|uniprotkb:E9PAR9|uniprotkb:A8K1R6|uniprotkb:Q63ZY4 psi-mi:g3bp2_human(display_long)|uniprotkb:GAP SH3 domain-binding protein 2(gene name synonym)|uniprotkb:G3BP2(gene name)|psi-mi:G3BP2(display_short)|uniprotkb:KIAA0660(gene name synonym) psi-mi:atx2l_human(display_long)|uniprotkb:Ataxin-2 domain protein(gene name synonym)|uniprotkb:Ataxin-2-related protein(gene name synonym)|uniprotkb:ATXN2L(gene name)|psi-mi:ATXN2L(display_short)|uniprotkb:A2D(gene name synonym)|uniprotkb:A2LG(gene name synonym)|uniprotkb:A2LP(gene name synonym)|uniprotkb:A2RP(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514381|imex:IM-12079-40 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_036429.2|refseq:NP_987100.1|refseq:NP_987101.1|ensembl:ENSG00000138757(gene)|ensembl:ENST00000677620(transcript)|ensembl:ENST00000678062(transcript)|ensembl:ENST00000678100(transcript)|ensembl:ENST00000678123(transcript)|ensembl:ENST00000678265(transcript)|ensembl:ENST00000678578(transcript)|ensembl:ENST00000678798(transcript)|ensembl:ENST00000678971(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007253"(cytoplasmic sequestering of NF-kappaB)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0034063"(stress granule assembly)|go:"GO:0045087"(innate immune response)|go:"GO:0051028"(mRNA transport)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0062029"(positive regulation of stress granule assembly)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR002075(Nuclear transport factor 2)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR018222|interpro:IPR032710|interpro:IPR034376|interpro:IPR034377|interpro:IPR035979|interpro:IPR039539|mint:Q9UN86|rcsb pdb:5DRV|ensembl:ENST00000359707(transcript)|ensembl:ENST00000395719(transcript)|ensembl:ENST00000676584(transcript)|ensembl:ENST00000676974(transcript)|ensembl:ENST00000677162(transcript)|ensembl:ENST00000677171(transcript)|ensembl:ENST00000677201(transcript)|ensembl:ENST00000677333(transcript)|ensembl:ENST00000677566(transcript)|ensembl:ENST00000677606(transcript)|refseq:XP_011530743.1|refseq:XP_005263439.1|refseq:XP_005263440.1|refseq:XP_016864365.1|refseq:XP_016864366.1|refseq:XP_016864367.1|refseq:XP_016864368.1|dip:DIP-50299N ensembl:ENSG00000168488(gene)|ensembl:ENST00000336783(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005829"(cytosol)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010603"(regulation of cytoplasmic mRNA processing body assembly)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0034063"(stress granule assembly)|go:"GO:0045296"(cadherin binding)|interpro:IPR009604(Ataxin-2, N-terminal)|interpro:IPR009818(Ataxin-2, C-terminal)|interpro:IPR025852|mint:Q8WWM7|refseq:NP_009176.2|refseq:NP_663760.1|refseq:NP_680780.1|refseq:NP_680781.1|refseq:XP_005255123.1|refseq:NP_059867.3|refseq:NP_680782.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:bYP8U2wviIqJBWcnLQnuoV0MhV89606 rogid:t7lrS10IM/5pt+rrbqBRowZ6b+09606 intact-crc:B0F3248A2A41773A|rigid:0TNucBI9yYzg+HXsmwovpmYCTDM false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UN86 uniprotkb:Q6NW34 intact:EBI-1044298|uniprotkb:O60606|uniprotkb:O75149|uniprotkb:Q9UPA1|ensembl:ENSP00000352738|ensembl:ENSP00000379069|ensembl:ENSP00000503228|ensembl:ENSP00000503239|ensembl:ENSP00000503355|ensembl:ENSP00000503669|ensembl:ENSP00000503911|ensembl:ENSP00000503943|ensembl:ENSP00000504101|ensembl:ENSP00000504159|ensembl:ENSP00000504316|ensembl:ENSP00000504361|ensembl:ENSP00000504371|ensembl:ENSP00000504496|ensembl:ENSP00000504523|ensembl:ENSP00000504585|ensembl:ENSP00000504698|ensembl:ENSP00000503504|uniprotkb:A8K6X1 intact:EBI-2514392|ensembl:ENSP00000320251|uniprotkb:Q9H7U0|uniprotkb:Q9UFM4|uniprotkb:Q68DM6|uniprotkb:D3DN69 psi-mi:g3bp2_human(display_long)|uniprotkb:GAP SH3 domain-binding protein 2(gene name synonym)|uniprotkb:G3BP2(gene name)|psi-mi:G3BP2(display_short)|uniprotkb:KIAA0660(gene name synonym) psi-mi:nepro_human(display_long)|uniprotkb:NEPRO(gene name)|psi-mi:NEPRO(display_short)|uniprotkb:C3orf17(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514381|imex:IM-12079-40 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_036429.2|refseq:NP_987100.1|refseq:NP_987101.1|ensembl:ENSG00000138757(gene)|ensembl:ENST00000677620(transcript)|ensembl:ENST00000678062(transcript)|ensembl:ENST00000678100(transcript)|ensembl:ENST00000678123(transcript)|ensembl:ENST00000678265(transcript)|ensembl:ENST00000678578(transcript)|ensembl:ENST00000678798(transcript)|ensembl:ENST00000678971(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007253"(cytoplasmic sequestering of NF-kappaB)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0034063"(stress granule assembly)|go:"GO:0045087"(innate immune response)|go:"GO:0051028"(mRNA transport)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0062029"(positive regulation of stress granule assembly)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR002075(Nuclear transport factor 2)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR018222|interpro:IPR032710|interpro:IPR034376|interpro:IPR034377|interpro:IPR035979|interpro:IPR039539|mint:Q9UN86|rcsb pdb:5DRV|ensembl:ENST00000359707(transcript)|ensembl:ENST00000395719(transcript)|ensembl:ENST00000676584(transcript)|ensembl:ENST00000676974(transcript)|ensembl:ENST00000677162(transcript)|ensembl:ENST00000677171(transcript)|ensembl:ENST00000677201(transcript)|ensembl:ENST00000677333(transcript)|ensembl:ENST00000677566(transcript)|ensembl:ENST00000677606(transcript)|refseq:XP_011530743.1|refseq:XP_005263439.1|refseq:XP_005263440.1|refseq:XP_016864365.1|refseq:XP_016864366.1|refseq:XP_016864367.1|refseq:XP_016864368.1|dip:DIP-50299N refseq:NP_001306038.1|refseq:NP_001306039.1|refseq:NP_001306040.1|refseq:NP_001306041.1|refseq:NP_001306043.1|refseq:NP_001306044.1|ensembl:ENSG00000163608(gene)|ensembl:ENST00000314400(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|interpro:IPR027951|mint:Q6NW34|refseq:NP_056227.2 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:bYP8U2wviIqJBWcnLQnuoV0MhV89606 rogid:br4UAJBanB0yJJzizE1yXlJqtwQ9606 intact-crc:B0F3248A2A41773A|rigid:0TNucBI9yYzg+HXsmwovpmYCTDM false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UN86 uniprotkb:Q13823 intact:EBI-1044298|uniprotkb:O60606|uniprotkb:O75149|uniprotkb:Q9UPA1|ensembl:ENSP00000352738|ensembl:ENSP00000379069|ensembl:ENSP00000503228|ensembl:ENSP00000503239|ensembl:ENSP00000503355|ensembl:ENSP00000503669|ensembl:ENSP00000503911|ensembl:ENSP00000503943|ensembl:ENSP00000504101|ensembl:ENSP00000504159|ensembl:ENSP00000504316|ensembl:ENSP00000504361|ensembl:ENSP00000504371|ensembl:ENSP00000504496|ensembl:ENSP00000504523|ensembl:ENSP00000504585|ensembl:ENSP00000504698|ensembl:ENSP00000503504|uniprotkb:A8K6X1 intact:EBI-1043365|uniprotkb:Q9BWN7|ensembl:ENSP00000362153 psi-mi:g3bp2_human(display_long)|uniprotkb:GAP SH3 domain-binding protein 2(gene name synonym)|uniprotkb:G3BP2(gene name)|psi-mi:G3BP2(display_short)|uniprotkb:KIAA0660(gene name synonym) psi-mi:nog2_human(display_long)|uniprotkb:Autoantigen NGP-1(gene name synonym)|uniprotkb:GNL2(gene name)|psi-mi:GNL2(display_short)|uniprotkb:NGP1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514381|imex:IM-12079-40 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_036429.2|refseq:NP_987100.1|refseq:NP_987101.1|ensembl:ENSG00000138757(gene)|ensembl:ENST00000677620(transcript)|ensembl:ENST00000678062(transcript)|ensembl:ENST00000678100(transcript)|ensembl:ENST00000678123(transcript)|ensembl:ENST00000678265(transcript)|ensembl:ENST00000678578(transcript)|ensembl:ENST00000678798(transcript)|ensembl:ENST00000678971(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007253"(cytoplasmic sequestering of NF-kappaB)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0034063"(stress granule assembly)|go:"GO:0045087"(innate immune response)|go:"GO:0051028"(mRNA transport)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0062029"(positive regulation of stress granule assembly)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR002075(Nuclear transport factor 2)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR018222|interpro:IPR032710|interpro:IPR034376|interpro:IPR034377|interpro:IPR035979|interpro:IPR039539|mint:Q9UN86|rcsb pdb:5DRV|ensembl:ENST00000359707(transcript)|ensembl:ENST00000395719(transcript)|ensembl:ENST00000676584(transcript)|ensembl:ENST00000676974(transcript)|ensembl:ENST00000677162(transcript)|ensembl:ENST00000677171(transcript)|ensembl:ENST00000677201(transcript)|ensembl:ENST00000677333(transcript)|ensembl:ENST00000677566(transcript)|ensembl:ENST00000677606(transcript)|refseq:XP_011530743.1|refseq:XP_005263439.1|refseq:XP_005263440.1|refseq:XP_016864365.1|refseq:XP_016864366.1|refseq:XP_016864367.1|refseq:XP_016864368.1|dip:DIP-50299N ensembl:ENSG00000134697(gene)|ensembl:ENST00000373062(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0016020"(membrane)|go:"GO:0042254"(ribosome biogenesis)|interpro:IPR006073(GTP1/OBG)|interpro:IPR012971(NGP1, N-terminal)|interpro:IPR023179|interpro:IPR024929|interpro:IPR027417|interpro:IPR030378|mint:Q13823|rcsb pdb:6LSS|rcsb pdb:6LU8|refseq:NP_037417.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:bYP8U2wviIqJBWcnLQnuoV0MhV89606 rogid:CgIg/QNhk71SHIhV4iLvIuC/HUo9606 intact-crc:B0F3248A2A41773A|rigid:0TNucBI9yYzg+HXsmwovpmYCTDM false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UN86 uniprotkb:Q96RL1 intact:EBI-1044298|uniprotkb:O60606|uniprotkb:O75149|uniprotkb:Q9UPA1|ensembl:ENSP00000352738|ensembl:ENSP00000379069|ensembl:ENSP00000503228|ensembl:ENSP00000503239|ensembl:ENSP00000503355|ensembl:ENSP00000503669|ensembl:ENSP00000503911|ensembl:ENSP00000503943|ensembl:ENSP00000504101|ensembl:ENSP00000504159|ensembl:ENSP00000504316|ensembl:ENSP00000504361|ensembl:ENSP00000504371|ensembl:ENSP00000504496|ensembl:ENSP00000504523|ensembl:ENSP00000504585|ensembl:ENSP00000504698|ensembl:ENSP00000503504|uniprotkb:A8K6X1 intact:EBI-725300|intact:EBI-1263554|uniprotkb:Q5XKQ1|uniprotkb:Q7Z3W7|uniprotkb:Q8N5B9|uniprotkb:Q9BZR1|uniprotkb:Q9BZR5|uniprotkb:Q9UHX7|uniprotkb:A8MSA1|uniprotkb:B3KMZ1|uniprotkb:B4E3N2|ensembl:ENSP00000366434|ensembl:ENSP00000421926 psi-mi:g3bp2_human(display_long)|uniprotkb:GAP SH3 domain-binding protein 2(gene name synonym)|uniprotkb:G3BP2(gene name)|psi-mi:G3BP2(display_short)|uniprotkb:KIAA0660(gene name synonym) psi-mi:uimc1_human(display_long)|uniprotkb:Retinoid X receptor-interacting protein 110(gene name synonym)|uniprotkb:Receptor-associated protein 80(gene name synonym)|uniprotkb:Ubiquitin interaction motif-containing protein 1(gene name synonym)|uniprotkb:UIMC1(gene name)|psi-mi:UIMC1(display_short)|uniprotkb:RAP80(gene name synonym)|uniprotkb:RXRIP110(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514381|imex:IM-12079-40 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_036429.2|refseq:NP_987100.1|refseq:NP_987101.1|ensembl:ENSG00000138757(gene)|ensembl:ENST00000677620(transcript)|ensembl:ENST00000678062(transcript)|ensembl:ENST00000678100(transcript)|ensembl:ENST00000678123(transcript)|ensembl:ENST00000678265(transcript)|ensembl:ENST00000678578(transcript)|ensembl:ENST00000678798(transcript)|ensembl:ENST00000678971(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007253"(cytoplasmic sequestering of NF-kappaB)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0034063"(stress granule assembly)|go:"GO:0045087"(innate immune response)|go:"GO:0051028"(mRNA transport)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0062029"(positive regulation of stress granule assembly)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR002075(Nuclear transport factor 2)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR018222|interpro:IPR032710|interpro:IPR034376|interpro:IPR034377|interpro:IPR035979|interpro:IPR039539|mint:Q9UN86|rcsb pdb:5DRV|ensembl:ENST00000359707(transcript)|ensembl:ENST00000395719(transcript)|ensembl:ENST00000676584(transcript)|ensembl:ENST00000676974(transcript)|ensembl:ENST00000677162(transcript)|ensembl:ENST00000677171(transcript)|ensembl:ENST00000677201(transcript)|ensembl:ENST00000677333(transcript)|ensembl:ENST00000677566(transcript)|ensembl:ENST00000677606(transcript)|refseq:XP_011530743.1|refseq:XP_005263439.1|refseq:XP_005263440.1|refseq:XP_016864365.1|refseq:XP_016864366.1|refseq:XP_016864367.1|refseq:XP_016864368.1|dip:DIP-50299N refseq:NP_001186226.1|refseq:NP_001186227.1|refseq:NP_057374.3|refseq:NP_001304890.1|ensembl:ENSG00000087206(gene)|ensembl:ENST00000377227(transcript)|ensembl:ENST00000511320(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006302"(double-strand break repair)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016604"(nuclear body)|go:"GO:0042393"(histone binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0070531"(BRCA1-A complex)|go:"GO:0070537"(histone H2A K63-linked deubiquitination)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR006642(Zinc finger, Rad18-type putative)|interpro:IPR038868|interpro:IPR040714|mint:Q96RL1|rcsb pdb:2MKF|rcsb pdb:2MKG|rcsb pdb:2N9E|rcsb pdb:2RR9|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473|refseq:XP_005265987.1|refseq:XP_005265993.1|refseq:XP_006714934.1|refseq:XP_016865063.1|refseq:XP_016865067.1|refseq:XP_016865068.1|dip:DIP-29936N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:bYP8U2wviIqJBWcnLQnuoV0MhV89606 rogid:j5ho+aD4tkX7bXXlROdiprUX1Mc9606 intact-crc:B0F3248A2A41773A|rigid:0TNucBI9yYzg+HXsmwovpmYCTDM false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UN86 uniprotkb:Q92901 intact:EBI-1044298|uniprotkb:O60606|uniprotkb:O75149|uniprotkb:Q9UPA1|ensembl:ENSP00000352738|ensembl:ENSP00000379069|ensembl:ENSP00000503228|ensembl:ENSP00000503239|ensembl:ENSP00000503355|ensembl:ENSP00000503669|ensembl:ENSP00000503911|ensembl:ENSP00000503943|ensembl:ENSP00000504101|ensembl:ENSP00000504159|ensembl:ENSP00000504316|ensembl:ENSP00000504361|ensembl:ENSP00000504371|ensembl:ENSP00000504496|ensembl:ENSP00000504523|ensembl:ENSP00000504585|ensembl:ENSP00000504698|ensembl:ENSP00000503504|uniprotkb:A8K6X1 intact:EBI-2514377|ensembl:ENSP00000268661 psi-mi:g3bp2_human(display_long)|uniprotkb:GAP SH3 domain-binding protein 2(gene name synonym)|uniprotkb:G3BP2(gene name)|psi-mi:G3BP2(display_short)|uniprotkb:KIAA0660(gene name synonym) psi-mi:rl3l_human(display_long)|uniprotkb:RPL3L(gene name)|psi-mi:RPL3L(display_short)|uniprotkb:Large ribosomal subunit protein uL3-like(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514381|imex:IM-12079-40 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_036429.2|refseq:NP_987100.1|refseq:NP_987101.1|ensembl:ENSG00000138757(gene)|ensembl:ENST00000677620(transcript)|ensembl:ENST00000678062(transcript)|ensembl:ENST00000678100(transcript)|ensembl:ENST00000678123(transcript)|ensembl:ENST00000678265(transcript)|ensembl:ENST00000678578(transcript)|ensembl:ENST00000678798(transcript)|ensembl:ENST00000678971(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007253"(cytoplasmic sequestering of NF-kappaB)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0034063"(stress granule assembly)|go:"GO:0045087"(innate immune response)|go:"GO:0051028"(mRNA transport)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0062029"(positive regulation of stress granule assembly)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR002075(Nuclear transport factor 2)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR018222|interpro:IPR032710|interpro:IPR034376|interpro:IPR034377|interpro:IPR035979|interpro:IPR039539|mint:Q9UN86|rcsb pdb:5DRV|ensembl:ENST00000359707(transcript)|ensembl:ENST00000395719(transcript)|ensembl:ENST00000676584(transcript)|ensembl:ENST00000676974(transcript)|ensembl:ENST00000677162(transcript)|ensembl:ENST00000677171(transcript)|ensembl:ENST00000677201(transcript)|ensembl:ENST00000677333(transcript)|ensembl:ENST00000677566(transcript)|ensembl:ENST00000677606(transcript)|refseq:XP_011530743.1|refseq:XP_005263439.1|refseq:XP_005263440.1|refseq:XP_016864365.1|refseq:XP_016864366.1|refseq:XP_016864367.1|refseq:XP_016864368.1|dip:DIP-50299N ensembl:ENSG00000140986(gene)|ensembl:ENST00000268661(transcript)|go:"GO:0000027"(ribosomal large subunit assembly)|go:"GO:0003723"(RNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005840"(ribosome)|go:"GO:0006412"(translation)|go:"GO:0016020"(membrane)|go:"GO:0022625"(cytosolic large ribosomal subunit)|interpro:IPR000597(Ribosomal protein L3)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)|interpro:IPR019926|reactome:R-HSA-156827|reactome:R-HSA-156902|reactome:R-HSA-1799339|reactome:R-HSA-192823|reactome:R-HSA-2408557|reactome:R-HSA-6791226|reactome:R-HSA-72689|reactome:R-HSA-72706|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-9633012|reactome:R-HSA-975956|reactome:R-HSA-975957|refseq:NP_005052.1|ensembl:ENSP00000268661 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:bYP8U2wviIqJBWcnLQnuoV0MhV89606 rogid:hG1wpRH7DNIbNB4zCONsF22W3zc9606 intact-crc:B0F3248A2A41773A|rigid:0TNucBI9yYzg+HXsmwovpmYCTDM false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q13283 uniprotkb:Q8N3C0 intact:EBI-1047359|intact:EBI-1384154|ensembl:ENSP00000348578|ensembl:ENSP00000377681|ensembl:ENSP00000430480|ensembl:ENSP00000502880|ensembl:ENSP00000503039|ensembl:ENSP00000503699|ensembl:ENSP00000503939|ensembl:ENSP00000504140|ensembl:ENSP00000504627|uniprotkb:Q5HYE9 intact:EBI-1210710|uniprotkb:Q9NTR0|uniprotkb:O43738|uniprotkb:Q5VTN2|uniprotkb:Q9H1I9|uniprotkb:E7EW23|uniprotkb:Q4G1A0|uniprotkb:Q9H5A2|ensembl:ENSP00000358159 psi-mi:g3bp1_human(display_long)|uniprotkb:G3BP1(gene name)|psi-mi:G3BP1(display_short)|uniprotkb:G3BP(gene name synonym)|uniprotkb:ATP-dependent DNA helicase VIII(gene name synonym)|uniprotkb:GAP SH3 domain-binding protein 1(gene name synonym) psi-mi:ascc3_human(display_long)|uniprotkb:ASCC3(gene name)|psi-mi:ASCC3(display_short)|uniprotkb:HELIC1(gene name synonym)|uniprotkb:ASC-1 complex subunit p200(gene name synonym)|uniprotkb:Trip4 complex subunit p200(gene name synonym)|uniprotkb:Helicase, ATP binding 1(gene name synonym)|uniprotkb:RQT2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514311|imex:IM-12079-90 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005745.1|refseq:NP_938405.1|ensembl:ENSG00000145907(gene)|go:"GO:0003729"(mRNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0033677"(DNA/RNA helicase activity)|go:"GO:0034063"(stress granule assembly)|go:"GO:0043204"(perikaryon)|go:"GO:0045087"(innate immune response)|go:"GO:0051607"(defense response to virus)|go:"GO:0062029"(positive regulation of stress granule assembly)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR002075(Nuclear transport factor 2)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR018222|interpro:IPR032710|interpro:IPR034374|interpro:IPR034375|interpro:IPR035979|interpro:IPR039539|mint:Q13283|ensembl:ENST00000356245(transcript)|rcsb pdb:3Q90|rcsb pdb:4FCJ|rcsb pdb:4FCM|rcsb pdb:4IIA|rcsb pdb:5FW5|rcsb pdb:6TA7|ensembl:ENST00000394123(transcript)|ensembl:ENST00000522761(transcript)|ensembl:ENST00000676827(transcript)|ensembl:ENST00000676978(transcript)|ensembl:ENST00000677323(transcript)|ensembl:ENST00000678070(transcript)|ensembl:ENST00000678101(transcript)|ensembl:ENST00000678925(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|refseq:XP_006714812.1|refseq:XP_006714813.1|refseq:XP_016864411.1|refseq:XP_016864412.1 refseq:NP_001271200.1|refseq:NP_006819.2|refseq:NP_071374.1|ensembl:ENSG00000112249(gene)|ensembl:ENST00000369162(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006307"(DNA dealkylation involved in DNA repair)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0043138"(3'-5' DNA helicase activity)|go:"GO:0099053"(activating signal cointegrator 1 complex)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR004179(Sec63)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR027417|interpro:IPR035892|interpro:IPR036388|interpro:IPR036390|mint:Q8N3C0|rcsb pdb:6YXQ|reactome:R-HSA-112126|go:"GO:0005829"(cytosol) psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/11/01 rogid:0ZRCHNVEmmtGEOASNwg3kIm2uys9606 rogid:HAdhxBtWHxdw7k0GkyqBtloVyPY9606 intact-crc:8E216454F46800F3|rigid:gx7W2dWGqMoA6e4mZ3ejWOlMHeM false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q13283 uniprotkb:Q12894 intact:EBI-1047359|intact:EBI-1384154|ensembl:ENSP00000348578|ensembl:ENSP00000377681|ensembl:ENSP00000430480|ensembl:ENSP00000502880|ensembl:ENSP00000503039|ensembl:ENSP00000503699|ensembl:ENSP00000503939|ensembl:ENSP00000504140|ensembl:ENSP00000504627|uniprotkb:Q5HYE9 intact:EBI-2512448|ensembl:ENSP00000402849|intact:EBI-6115935|uniprotkb:Q9BVB4|uniprotkb:Q9UJ88 psi-mi:g3bp1_human(display_long)|uniprotkb:G3BP1(gene name)|psi-mi:G3BP1(display_short)|uniprotkb:G3BP(gene name synonym)|uniprotkb:ATP-dependent DNA helicase VIII(gene name synonym)|uniprotkb:GAP SH3 domain-binding protein 1(gene name synonym) psi-mi:ifrd2_human(display_long)|uniprotkb:Protein SKMC15(gene name synonym)|uniprotkb:IFRD2(gene name)|psi-mi:IFRD2(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514311|imex:IM-12079-90 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005745.1|refseq:NP_938405.1|ensembl:ENSG00000145907(gene)|go:"GO:0003729"(mRNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0033677"(DNA/RNA helicase activity)|go:"GO:0034063"(stress granule assembly)|go:"GO:0043204"(perikaryon)|go:"GO:0045087"(innate immune response)|go:"GO:0051607"(defense response to virus)|go:"GO:0062029"(positive regulation of stress granule assembly)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR002075(Nuclear transport factor 2)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR018222|interpro:IPR032710|interpro:IPR034374|interpro:IPR034375|interpro:IPR035979|interpro:IPR039539|mint:Q13283|ensembl:ENST00000356245(transcript)|rcsb pdb:3Q90|rcsb pdb:4FCJ|rcsb pdb:4FCM|rcsb pdb:4IIA|rcsb pdb:5FW5|rcsb pdb:6TA7|ensembl:ENST00000394123(transcript)|ensembl:ENST00000522761(transcript)|ensembl:ENST00000676827(transcript)|ensembl:ENST00000676978(transcript)|ensembl:ENST00000677323(transcript)|ensembl:ENST00000678070(transcript)|ensembl:ENST00000678101(transcript)|ensembl:ENST00000678925(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|refseq:XP_006714812.1|refseq:XP_006714813.1|refseq:XP_016864411.1|refseq:XP_016864412.1 ensembl:ENSG00000214706(gene)|ensembl:ENST00000417626(transcript)|go:"GO:0005634"(nucleus)|interpro:IPR006921(Interferon-related protein conserved region)|interpro:IPR007701(Interferon-related developmental regulator)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR039777|refseq:NP_006755.4 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/11/01 rogid:0ZRCHNVEmmtGEOASNwg3kIm2uys9606 rogid:ktxpbUgNcw2DWOJw8o1R4s+U3a09606 intact-crc:8E216454F46800F3|rigid:gx7W2dWGqMoA6e4mZ3ejWOlMHeM false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q13283 uniprotkb:Q9UNN5 intact:EBI-1047359|intact:EBI-1384154|ensembl:ENSP00000348578|ensembl:ENSP00000377681|ensembl:ENSP00000430480|ensembl:ENSP00000502880|ensembl:ENSP00000503039|ensembl:ENSP00000503699|ensembl:ENSP00000503939|ensembl:ENSP00000504140|ensembl:ENSP00000504627|uniprotkb:Q5HYE9 intact:EBI-718246|uniprotkb:Q9UF34|uniprotkb:Q9UNT3|uniprotkb:Q9Y2Z3|uniprotkb:Q549F0|ensembl:ENSP00000379457 psi-mi:g3bp1_human(display_long)|uniprotkb:G3BP1(gene name)|psi-mi:G3BP1(display_short)|uniprotkb:G3BP(gene name synonym)|uniprotkb:ATP-dependent DNA helicase VIII(gene name synonym)|uniprotkb:GAP SH3 domain-binding protein 1(gene name synonym) psi-mi:faf1_human(display_long)|uniprotkb:FAF1(gene name)|psi-mi:FAF1(display_short)|uniprotkb:CGI-03(orf name)|uniprotkb:UBXD12(gene name synonym)|uniprotkb:UBXN3A(gene name synonym)|uniprotkb:UBX domain-containing protein 3A(gene name synonym)|uniprotkb:UBX domain-containing protein 12(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514311|imex:IM-12079-90 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005745.1|refseq:NP_938405.1|ensembl:ENSG00000145907(gene)|go:"GO:0003729"(mRNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0033677"(DNA/RNA helicase activity)|go:"GO:0034063"(stress granule assembly)|go:"GO:0043204"(perikaryon)|go:"GO:0045087"(innate immune response)|go:"GO:0051607"(defense response to virus)|go:"GO:0062029"(positive regulation of stress granule assembly)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR002075(Nuclear transport factor 2)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR018222|interpro:IPR032710|interpro:IPR034374|interpro:IPR034375|interpro:IPR035979|interpro:IPR039539|mint:Q13283|ensembl:ENST00000356245(transcript)|rcsb pdb:3Q90|rcsb pdb:4FCJ|rcsb pdb:4FCM|rcsb pdb:4IIA|rcsb pdb:5FW5|rcsb pdb:6TA7|ensembl:ENST00000394123(transcript)|ensembl:ENST00000522761(transcript)|ensembl:ENST00000676827(transcript)|ensembl:ENST00000676978(transcript)|ensembl:ENST00000677323(transcript)|ensembl:ENST00000678070(transcript)|ensembl:ENST00000678101(transcript)|ensembl:ENST00000678925(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|refseq:XP_006714812.1|refseq:XP_006714813.1|refseq:XP_016864411.1|refseq:XP_016864412.1 refseq:NP_008982.1|ensembl:ENSP00000379457|ensembl:ENSG00000185104(gene)|ensembl:ENST00000396153(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007253"(cytoplasmic sequestering of NF-kappaB)|go:"GO:0008219"(cell death)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0031265"(CD95 death-inducing signaling complex)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034098"(VCP-NPL4-UFD1 AAA ATPase complex)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1903364"(positive regulation of cellular protein catabolic process)|interpro:IPR001012(UBX)|interpro:IPR006577(UAS)|interpro:IPR029071|interpro:IPR033043|interpro:IPR036249|interpro:IPR044541|rcsb pdb:1H8C|rcsb pdb:2DZM|rcsb pdb:2EC4|rcsb pdb:3E21|rcsb pdb:3QC8|rcsb pdb:3QCA|rcsb pdb:3QQ8|rcsb pdb:3QWZ|rcsb pdb:3QX1|rcsb pdb:3R3M|go:"GO:0031072"(heat shock protein binding)|dip:DIP-38245N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/11/01 rogid:0ZRCHNVEmmtGEOASNwg3kIm2uys9606 rogid:jYlrz7+swvye+qZ/6F4yTv74wLI9606 intact-crc:8E216454F46800F3|rigid:gx7W2dWGqMoA6e4mZ3ejWOlMHeM false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q13283 uniprotkb:Q96EY4 intact:EBI-1047359|intact:EBI-1384154|ensembl:ENSP00000348578|ensembl:ENSP00000377681|ensembl:ENSP00000430480|ensembl:ENSP00000502880|ensembl:ENSP00000503039|ensembl:ENSP00000503699|ensembl:ENSP00000503939|ensembl:ENSP00000504140|ensembl:ENSP00000504627|uniprotkb:Q5HYE9 intact:EBI-1045338|uniprotkb:Q0P6E4|uniprotkb:Q0P6J1|uniprotkb:Q9NUR7|ensembl:ENSP00000351380 psi-mi:g3bp1_human(display_long)|uniprotkb:G3BP1(gene name)|psi-mi:G3BP1(display_short)|uniprotkb:G3BP(gene name synonym)|uniprotkb:ATP-dependent DNA helicase VIII(gene name synonym)|uniprotkb:GAP SH3 domain-binding protein 1(gene name synonym) psi-mi:tma16_human(display_long)|uniprotkb:TMA16(gene name)|psi-mi:TMA16(display_short)|uniprotkb:C4orf43(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514311|imex:IM-12079-90 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005745.1|refseq:NP_938405.1|ensembl:ENSG00000145907(gene)|go:"GO:0003729"(mRNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0033677"(DNA/RNA helicase activity)|go:"GO:0034063"(stress granule assembly)|go:"GO:0043204"(perikaryon)|go:"GO:0045087"(innate immune response)|go:"GO:0051607"(defense response to virus)|go:"GO:0062029"(positive regulation of stress granule assembly)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR002075(Nuclear transport factor 2)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR018222|interpro:IPR032710|interpro:IPR034374|interpro:IPR034375|interpro:IPR035979|interpro:IPR039539|mint:Q13283|ensembl:ENST00000356245(transcript)|rcsb pdb:3Q90|rcsb pdb:4FCJ|rcsb pdb:4FCM|rcsb pdb:4IIA|rcsb pdb:5FW5|rcsb pdb:6TA7|ensembl:ENST00000394123(transcript)|ensembl:ENST00000522761(transcript)|ensembl:ENST00000676827(transcript)|ensembl:ENST00000676978(transcript)|ensembl:ENST00000677323(transcript)|ensembl:ENST00000678070(transcript)|ensembl:ENST00000678101(transcript)|ensembl:ENST00000678925(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|refseq:XP_006714812.1|refseq:XP_006714813.1|refseq:XP_016864411.1|refseq:XP_016864412.1 refseq:NP_060822.2|ensembl:ENSG00000198498(gene)|ensembl:ENST00000358572(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|interpro:IPR021346|interpro:IPR038356|mint:Q96EY4|rcsb pdb:6LSS|rcsb pdb:6LU8 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/11/01 rogid:0ZRCHNVEmmtGEOASNwg3kIm2uys9606 rogid:SpEUtN6fodLyKZOgY6Y7AXfVBRY9606 intact-crc:8E216454F46800F3|rigid:gx7W2dWGqMoA6e4mZ3ejWOlMHeM false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q13283 uniprotkb:P35658 intact:EBI-1047359|intact:EBI-1384154|ensembl:ENSP00000348578|ensembl:ENSP00000377681|ensembl:ENSP00000430480|ensembl:ENSP00000502880|ensembl:ENSP00000503039|ensembl:ENSP00000503699|ensembl:ENSP00000503939|ensembl:ENSP00000504140|ensembl:ENSP00000504627|uniprotkb:Q5HYE9 intact:EBI-1222270|uniprotkb:A6NFQ0|uniprotkb:Q15010|uniprotkb:Q3KQZ0|uniprotkb:Q5JUP7|uniprotkb:Q75R47|uniprotkb:Q86XD3|intact:EBI-2555216|ensembl:ENSP00000352400 psi-mi:g3bp1_human(display_long)|uniprotkb:G3BP1(gene name)|psi-mi:G3BP1(display_short)|uniprotkb:G3BP(gene name synonym)|uniprotkb:ATP-dependent DNA helicase VIII(gene name synonym)|uniprotkb:GAP SH3 domain-binding protein 1(gene name synonym) psi-mi:nu214_human(display_long)|uniprotkb:NUP214(gene name)|psi-mi:NUP214(display_short)|uniprotkb:CAIN(gene name synonym)|uniprotkb:CAN(gene name synonym)|uniprotkb:KIAA0023(gene name synonym)|uniprotkb:Nucleoporin Nup214(gene name synonym)|uniprotkb:214 kDa nucleoporin(gene name synonym)|uniprotkb:Protein CAN(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514311|imex:IM-12079-90 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005745.1|refseq:NP_938405.1|ensembl:ENSG00000145907(gene)|go:"GO:0003729"(mRNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0033677"(DNA/RNA helicase activity)|go:"GO:0034063"(stress granule assembly)|go:"GO:0043204"(perikaryon)|go:"GO:0045087"(innate immune response)|go:"GO:0051607"(defense response to virus)|go:"GO:0062029"(positive regulation of stress granule assembly)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR002075(Nuclear transport factor 2)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR018222|interpro:IPR032710|interpro:IPR034374|interpro:IPR034375|interpro:IPR035979|interpro:IPR039539|mint:Q13283|ensembl:ENST00000356245(transcript)|rcsb pdb:3Q90|rcsb pdb:4FCJ|rcsb pdb:4FCM|rcsb pdb:4IIA|rcsb pdb:5FW5|rcsb pdb:6TA7|ensembl:ENST00000394123(transcript)|ensembl:ENST00000522761(transcript)|ensembl:ENST00000676827(transcript)|ensembl:ENST00000676978(transcript)|ensembl:ENST00000677323(transcript)|ensembl:ENST00000678070(transcript)|ensembl:ENST00000678101(transcript)|ensembl:ENST00000678925(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|refseq:XP_006714812.1|refseq:XP_006714813.1|refseq:XP_016864411.1|refseq:XP_016864412.1 ensembl:ENSP00000352400|ensembl:ENST00000411637|ensembl:ENSP00000396576|refseq:NP_005076.3|refseq:NP_001305253.1|refseq:NP_001305254.1|dip:DIP-38367N|rcsb pdb:3FMP|rcsb pdb:5DIS|reactome:R-HSA-1169408|reactome:R-HSA-159227|reactome:R-HSA-159230|reactome:R-HSA-159231|reactome:R-HSA-159236|reactome:R-HSA-165054|reactome:R-HSA-168271|reactome:R-HSA-168276|reactome:R-HSA-168325|reactome:R-HSA-168333|reactome:R-HSA-170822|reactome:R-HSA-180746|reactome:R-HSA-180910|reactome:R-HSA-191859|reactome:R-HSA-3108214|reactome:R-HSA-3232142|reactome:R-HSA-3301854|reactome:R-HSA-3371453|reactome:R-HSA-4085377|reactome:R-HSA-450520|reactome:R-HSA-4551638|reactome:R-HSA-4570464|reactome:R-HSA-4615885|reactome:R-HSA-5578749|reactome:R-HSA-5619107|reactome:R-HSA-6784531|reactome:R-HSA-9609690|reactome:R-HSA-9610379|rcsb pdb:3FMO|ensembl:ENSG00000126883(gene)|ensembl:ENST00000359428(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005049"(nuclear export signal receptor activity)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006405"(RNA export from nucleus)|go:"GO:0006406"(mRNA export from nucleus)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0017056"(structural constituent of nuclear pore)|go:"GO:0046822"(regulation of nucleocytoplasmic transport)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:1990876"(cytoplasmic side of nuclear pore)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR026054|interpro:IPR041553|mint:P35658|rcsb pdb:2OIT|rcsb pdb:3FHC psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/11/01 rogid:0ZRCHNVEmmtGEOASNwg3kIm2uys9606 rogid:cW7RIiR4uhQgXIaByMiW3niFtTo9606 intact-crc:8E216454F46800F3|rigid:gx7W2dWGqMoA6e4mZ3ejWOlMHeM false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q13283 uniprotkb:P54105 intact:EBI-1047359|intact:EBI-1384154|ensembl:ENSP00000348578|ensembl:ENSP00000377681|ensembl:ENSP00000430480|ensembl:ENSP00000502880|ensembl:ENSP00000503039|ensembl:ENSP00000503699|ensembl:ENSP00000503939|ensembl:ENSP00000504140|ensembl:ENSP00000504627|uniprotkb:Q5HYE9 intact:EBI-724693|uniprotkb:Q0VDK6|uniprotkb:Q9NRD2|uniprotkb:Q9NRD3|uniprotkb:B2RCS9|ensembl:ENSP00000433919|ensembl:ENSP00000434311 psi-mi:g3bp1_human(display_long)|uniprotkb:G3BP1(gene name)|psi-mi:G3BP1(display_short)|uniprotkb:G3BP(gene name synonym)|uniprotkb:ATP-dependent DNA helicase VIII(gene name synonym)|uniprotkb:GAP SH3 domain-binding protein 1(gene name synonym) psi-mi:icln_human(display_long)|uniprotkb:Chloride conductance regulatory protein ICln(gene name synonym)|uniprotkb:Chloride channel, nucleotide sensitive 1A(gene name synonym)|uniprotkb:Chloride ion current inducer protein(gene name synonym)|uniprotkb:Reticulocyte pICln(gene name synonym)|uniprotkb:CLNS1A(gene name)|psi-mi:CLNS1A(display_short)|uniprotkb:ICLN(gene name synonym)|uniprotkb:CLCI(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514311|imex:IM-12079-90 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005745.1|refseq:NP_938405.1|ensembl:ENSG00000145907(gene)|go:"GO:0003729"(mRNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0033677"(DNA/RNA helicase activity)|go:"GO:0034063"(stress granule assembly)|go:"GO:0043204"(perikaryon)|go:"GO:0045087"(innate immune response)|go:"GO:0051607"(defense response to virus)|go:"GO:0062029"(positive regulation of stress granule assembly)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR002075(Nuclear transport factor 2)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR018222|interpro:IPR032710|interpro:IPR034374|interpro:IPR034375|interpro:IPR035979|interpro:IPR039539|mint:Q13283|ensembl:ENST00000356245(transcript)|rcsb pdb:3Q90|rcsb pdb:4FCJ|rcsb pdb:4FCM|rcsb pdb:4IIA|rcsb pdb:5FW5|rcsb pdb:6TA7|ensembl:ENST00000394123(transcript)|ensembl:ENST00000522761(transcript)|ensembl:ENST00000676827(transcript)|ensembl:ENST00000676978(transcript)|ensembl:ENST00000677323(transcript)|ensembl:ENST00000678070(transcript)|ensembl:ENST00000678101(transcript)|ensembl:ENST00000678925(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|refseq:XP_006714812.1|refseq:XP_006714813.1|refseq:XP_016864411.1|refseq:XP_016864412.1 refseq:NP_001284.1|refseq:NP_001298128.1|refseq:NP_001298129.1|refseq:NP_001298130.1|refseq:NP_001298131.1|ensembl:ENSG00000074201(gene)|ensembl:ENST00000525428(transcript)|ensembl:ENST00000528364(transcript)|go:"GO:0000387"(spliceosomal snRNP assembly)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006821"(chloride transport)|go:"GO:0006884"(cell volume homeostasis)|go:"GO:0034709"(methylosome)|go:"GO:0034715"(pICln-Sm protein complex)|interpro:IPR003521(Nucleotide-sensitive chloride conductance regulator)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR039924|mint:P54105|rcsb pdb:6V0O|reactome:R-HSA-191859|dip:DIP-44185N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/11/01 rogid:0ZRCHNVEmmtGEOASNwg3kIm2uys9606 rogid:dGx9UwPj9VBp1CiPTRCXnT3IYt89606 intact-crc:8E216454F46800F3|rigid:gx7W2dWGqMoA6e4mZ3ejWOlMHeM false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q13283 uniprotkb:Q8NI36 intact:EBI-1047359|intact:EBI-1384154|ensembl:ENSP00000348578|ensembl:ENSP00000377681|ensembl:ENSP00000430480|ensembl:ENSP00000502880|ensembl:ENSP00000503039|ensembl:ENSP00000503699|ensembl:ENSP00000503939|ensembl:ENSP00000504140|ensembl:ENSP00000504627|uniprotkb:Q5HYE9 intact:EBI-2512413|ensembl:ENSP00000423067|ensembl:ENSP00000479950|uniprotkb:A2RUS4|uniprotkb:Q8N1Q2|uniprotkb:Q68E02 psi-mi:g3bp1_human(display_long)|uniprotkb:G3BP1(gene name)|psi-mi:G3BP1(display_short)|uniprotkb:G3BP(gene name synonym)|uniprotkb:ATP-dependent DNA helicase VIII(gene name synonym)|uniprotkb:GAP SH3 domain-binding protein 1(gene name synonym) psi-mi:wdr36_human(display_long)|uniprotkb:WDR36(gene name)|psi-mi:WDR36(display_short)|uniprotkb:T-cell activation WD repeat-containing protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514311|imex:IM-12079-90 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005745.1|refseq:NP_938405.1|ensembl:ENSG00000145907(gene)|go:"GO:0003729"(mRNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0033677"(DNA/RNA helicase activity)|go:"GO:0034063"(stress granule assembly)|go:"GO:0043204"(perikaryon)|go:"GO:0045087"(innate immune response)|go:"GO:0051607"(defense response to virus)|go:"GO:0062029"(positive regulation of stress granule assembly)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR002075(Nuclear transport factor 2)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR018222|interpro:IPR032710|interpro:IPR034374|interpro:IPR034375|interpro:IPR035979|interpro:IPR039539|mint:Q13283|ensembl:ENST00000356245(transcript)|rcsb pdb:3Q90|rcsb pdb:4FCJ|rcsb pdb:4FCM|rcsb pdb:4IIA|rcsb pdb:5FW5|rcsb pdb:6TA7|ensembl:ENST00000394123(transcript)|ensembl:ENST00000522761(transcript)|ensembl:ENST00000676827(transcript)|ensembl:ENST00000676978(transcript)|ensembl:ENST00000677323(transcript)|ensembl:ENST00000678070(transcript)|ensembl:ENST00000678101(transcript)|ensembl:ENST00000678925(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|refseq:XP_006714812.1|refseq:XP_006714813.1|refseq:XP_016864411.1|refseq:XP_016864412.1 ensembl:ENSG00000134987(gene)|ensembl:ENST00000506538(transcript)|ensembl:ENST00000612402(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006364"(rRNA processing)|go:"GO:0007601"(visual perception)|go:"GO:0032040"(small-subunit processome)|go:"GO:0034388"(Pwp2p-containing subcomplex of 90S preribosome)|go:"GO:0050896"(response to stimulus)|interpro:IPR001680(WD40 repeat)|interpro:IPR007319(Small-subunit processome, Utp21)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR024977|interpro:IPR036322|reactome:R-HSA-6790901|reactome:R-HSA-6791226|go:"GO:0003723"(RNA binding)|refseq:NP_644810.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/11/01 rogid:0ZRCHNVEmmtGEOASNwg3kIm2uys9606 rogid:97Qc0ehUPTjCBcn3gjr0FY8Nnus9606 intact-crc:8E216454F46800F3|rigid:gx7W2dWGqMoA6e4mZ3ejWOlMHeM false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q13283 uniprotkb:Q9BRJ2 intact:EBI-1047359|intact:EBI-1384154|ensembl:ENSP00000348578|ensembl:ENSP00000377681|ensembl:ENSP00000430480|ensembl:ENSP00000502880|ensembl:ENSP00000503039|ensembl:ENSP00000503699|ensembl:ENSP00000503939|ensembl:ENSP00000504140|ensembl:ENSP00000504627|uniprotkb:Q5HYE9 intact:EBI-2514313|ensembl:ENSP00000483030|uniprotkb:Q6ZMJ5|uniprotkb:A1L436 psi-mi:g3bp1_human(display_long)|uniprotkb:G3BP1(gene name)|psi-mi:G3BP1(display_short)|uniprotkb:G3BP(gene name synonym)|uniprotkb:ATP-dependent DNA helicase VIII(gene name synonym)|uniprotkb:GAP SH3 domain-binding protein 1(gene name synonym) psi-mi:rm45_human(display_long)|uniprotkb:MRPL45(gene name)|psi-mi:MRPL45(display_short)|uniprotkb:Mitochondrial large ribosomal subunit protein mL45(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514311|imex:IM-12079-90 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005745.1|refseq:NP_938405.1|ensembl:ENSG00000145907(gene)|go:"GO:0003729"(mRNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0033677"(DNA/RNA helicase activity)|go:"GO:0034063"(stress granule assembly)|go:"GO:0043204"(perikaryon)|go:"GO:0045087"(innate immune response)|go:"GO:0051607"(defense response to virus)|go:"GO:0062029"(positive regulation of stress granule assembly)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR002075(Nuclear transport factor 2)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR018222|interpro:IPR032710|interpro:IPR034374|interpro:IPR034375|interpro:IPR035979|interpro:IPR039539|mint:Q13283|ensembl:ENST00000356245(transcript)|rcsb pdb:3Q90|rcsb pdb:4FCJ|rcsb pdb:4FCM|rcsb pdb:4IIA|rcsb pdb:5FW5|rcsb pdb:6TA7|ensembl:ENST00000394123(transcript)|ensembl:ENST00000522761(transcript)|ensembl:ENST00000676827(transcript)|ensembl:ENST00000676978(transcript)|ensembl:ENST00000677323(transcript)|ensembl:ENST00000678070(transcript)|ensembl:ENST00000678101(transcript)|ensembl:ENST00000678925(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|refseq:XP_006714812.1|refseq:XP_006714813.1|refseq:XP_016864411.1|refseq:XP_016864412.1 ensembl:ENSG00000277936(gene)|ensembl:ENST00000621878(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005762"(mitochondrial large ribosomal subunit)|interpro:IPR007379(Mitochondrial import inner membrane translocase, subunit Tim44)|interpro:IPR032710|rcsb pdb:3J7Y|rcsb pdb:3J9M|rcsb pdb:5OOL|rcsb pdb:5OOM|rcsb pdb:6I9R|rcsb pdb:6NU2|rcsb pdb:6NU3|rcsb pdb:6VLZ|rcsb pdb:6VMI|rcsb pdb:6ZM5|rcsb pdb:6ZM6|rcsb pdb:6ZS9|rcsb pdb:6ZSA|rcsb pdb:6ZSB|rcsb pdb:6ZSC|rcsb pdb:6ZSD|rcsb pdb:6ZSE|rcsb pdb:6ZSG|rcsb pdb:7A5F|rcsb pdb:7A5G|rcsb pdb:7A5H|rcsb pdb:7A5I|rcsb pdb:7A5J|rcsb pdb:7A5K|rcsb pdb:7L08|rcsb pdb:7L20|rcsb pdb:7O9K|rcsb pdb:7O9M|rcsb pdb:7ODR|rcsb pdb:7ODS|rcsb pdb:7ODT|rcsb pdb:7OF0|rcsb pdb:7OF2|rcsb pdb:7OF3|rcsb pdb:7OF4|rcsb pdb:7OF5|rcsb pdb:7OF6|rcsb pdb:7OF7|rcsb pdb:7OG4|reactome:R-HSA-5368286|reactome:R-HSA-5389840|reactome:R-HSA-5419276|dip:DIP-53786N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/11/01 rogid:0ZRCHNVEmmtGEOASNwg3kIm2uys9606 rogid:9NtO1r7W7U9BW3vB9RTRbwehBZ49606 intact-crc:8E216454F46800F3|rigid:gx7W2dWGqMoA6e4mZ3ejWOlMHeM false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q13283 uniprotkb:Q8WWM7 intact:EBI-1047359|intact:EBI-1384154|ensembl:ENSP00000348578|ensembl:ENSP00000377681|ensembl:ENSP00000430480|ensembl:ENSP00000502880|ensembl:ENSP00000503039|ensembl:ENSP00000503699|ensembl:ENSP00000503939|ensembl:ENSP00000504140|ensembl:ENSP00000504627|uniprotkb:Q5HYE9 intact:EBI-948363|ensembl:ENSP00000338718|uniprotkb:O95135|uniprotkb:Q6NVJ8|uniprotkb:Q6PJW6|uniprotkb:Q8IU61|uniprotkb:Q8IU95|uniprotkb:Q8WWM3|uniprotkb:Q8WWM4|uniprotkb:Q8WWM5|uniprotkb:Q8WWM6|uniprotkb:Q99703|uniprotkb:B9EGM2|uniprotkb:E9PAR9|uniprotkb:A8K1R6|uniprotkb:Q63ZY4 psi-mi:g3bp1_human(display_long)|uniprotkb:G3BP1(gene name)|psi-mi:G3BP1(display_short)|uniprotkb:G3BP(gene name synonym)|uniprotkb:ATP-dependent DNA helicase VIII(gene name synonym)|uniprotkb:GAP SH3 domain-binding protein 1(gene name synonym) psi-mi:atx2l_human(display_long)|uniprotkb:Ataxin-2 domain protein(gene name synonym)|uniprotkb:Ataxin-2-related protein(gene name synonym)|uniprotkb:ATXN2L(gene name)|psi-mi:ATXN2L(display_short)|uniprotkb:A2D(gene name synonym)|uniprotkb:A2LG(gene name synonym)|uniprotkb:A2LP(gene name synonym)|uniprotkb:A2RP(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514311|imex:IM-12079-90 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005745.1|refseq:NP_938405.1|ensembl:ENSG00000145907(gene)|go:"GO:0003729"(mRNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0033677"(DNA/RNA helicase activity)|go:"GO:0034063"(stress granule assembly)|go:"GO:0043204"(perikaryon)|go:"GO:0045087"(innate immune response)|go:"GO:0051607"(defense response to virus)|go:"GO:0062029"(positive regulation of stress granule assembly)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR002075(Nuclear transport factor 2)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR018222|interpro:IPR032710|interpro:IPR034374|interpro:IPR034375|interpro:IPR035979|interpro:IPR039539|mint:Q13283|ensembl:ENST00000356245(transcript)|rcsb pdb:3Q90|rcsb pdb:4FCJ|rcsb pdb:4FCM|rcsb pdb:4IIA|rcsb pdb:5FW5|rcsb pdb:6TA7|ensembl:ENST00000394123(transcript)|ensembl:ENST00000522761(transcript)|ensembl:ENST00000676827(transcript)|ensembl:ENST00000676978(transcript)|ensembl:ENST00000677323(transcript)|ensembl:ENST00000678070(transcript)|ensembl:ENST00000678101(transcript)|ensembl:ENST00000678925(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|refseq:XP_006714812.1|refseq:XP_006714813.1|refseq:XP_016864411.1|refseq:XP_016864412.1 ensembl:ENSG00000168488(gene)|ensembl:ENST00000336783(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005829"(cytosol)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010603"(regulation of cytoplasmic mRNA processing body assembly)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0034063"(stress granule assembly)|go:"GO:0045296"(cadherin binding)|interpro:IPR009604(Ataxin-2, N-terminal)|interpro:IPR009818(Ataxin-2, C-terminal)|interpro:IPR025852|mint:Q8WWM7|refseq:NP_009176.2|refseq:NP_663760.1|refseq:NP_680780.1|refseq:NP_680781.1|refseq:XP_005255123.1|refseq:NP_059867.3|refseq:NP_680782.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/11/01 rogid:0ZRCHNVEmmtGEOASNwg3kIm2uys9606 rogid:t7lrS10IM/5pt+rrbqBRowZ6b+09606 intact-crc:8E216454F46800F3|rigid:gx7W2dWGqMoA6e4mZ3ejWOlMHeM false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q13283 uniprotkb:Q5SRE5 intact:EBI-1047359|intact:EBI-1384154|ensembl:ENSP00000348578|ensembl:ENSP00000377681|ensembl:ENSP00000430480|ensembl:ENSP00000502880|ensembl:ENSP00000503039|ensembl:ENSP00000503699|ensembl:ENSP00000503939|ensembl:ENSP00000504140|ensembl:ENSP00000504627|uniprotkb:Q5HYE9 intact:EBI-1049404|uniprotkb:Q14675|uniprotkb:Q2TA87|uniprotkb:Q7Z3K8|uniprotkb:Q8IWF1|intact:EBI-2555229|ensembl:ENSP00000361658 psi-mi:g3bp1_human(display_long)|uniprotkb:G3BP1(gene name)|psi-mi:G3BP1(display_short)|uniprotkb:G3BP(gene name synonym)|uniprotkb:ATP-dependent DNA helicase VIII(gene name synonym)|uniprotkb:GAP SH3 domain-binding protein 1(gene name synonym) psi-mi:nu188_human(display_long)|uniprotkb:NUP188(gene name)|psi-mi:NUP188(display_short)|uniprotkb:KIAA0169(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514311|imex:IM-12079-90 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005745.1|refseq:NP_938405.1|ensembl:ENSG00000145907(gene)|go:"GO:0003729"(mRNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0033677"(DNA/RNA helicase activity)|go:"GO:0034063"(stress granule assembly)|go:"GO:0043204"(perikaryon)|go:"GO:0045087"(innate immune response)|go:"GO:0051607"(defense response to virus)|go:"GO:0062029"(positive regulation of stress granule assembly)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR002075(Nuclear transport factor 2)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR018222|interpro:IPR032710|interpro:IPR034374|interpro:IPR034375|interpro:IPR035979|interpro:IPR039539|mint:Q13283|ensembl:ENST00000356245(transcript)|rcsb pdb:3Q90|rcsb pdb:4FCJ|rcsb pdb:4FCM|rcsb pdb:4IIA|rcsb pdb:5FW5|rcsb pdb:6TA7|ensembl:ENST00000394123(transcript)|ensembl:ENST00000522761(transcript)|ensembl:ENST00000676827(transcript)|ensembl:ENST00000676978(transcript)|ensembl:ENST00000677323(transcript)|ensembl:ENST00000678070(transcript)|ensembl:ENST00000678101(transcript)|ensembl:ENST00000678925(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|refseq:XP_006714812.1|refseq:XP_006714813.1|refseq:XP_016864411.1|refseq:XP_016864412.1 refseq:NP_056169.1|ensembl:ENSG00000095319(gene)|ensembl:ENST00000372577(transcript)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005829"(cytosol)|go:"GO:0006405"(RNA export from nucleus)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0016020"(membrane)|go:"GO:0017056"(structural constituent of nuclear pore)|go:"GO:0044611"(nuclear pore inner ring)|go:"GO:0051028"(mRNA transport)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018864|interpro:IPR044840|mint:Q5SRE5|rcsb pdb:5IJO|reactome:R-HSA-1169408|reactome:R-HSA-159227|reactome:R-HSA-159230|reactome:R-HSA-159231|reactome:R-HSA-159236|reactome:R-HSA-165054|reactome:R-HSA-168271|reactome:R-HSA-168276|reactome:R-HSA-168325|reactome:R-HSA-168333|reactome:R-HSA-170822|reactome:R-HSA-180746|reactome:R-HSA-180910|reactome:R-HSA-191859|reactome:R-HSA-3108214|reactome:R-HSA-3232142|reactome:R-HSA-3301854|reactome:R-HSA-3371453|reactome:R-HSA-4085377|reactome:R-HSA-4551638|reactome:R-HSA-4570464|reactome:R-HSA-4615885|reactome:R-HSA-5578749|reactome:R-HSA-5619107|reactome:R-HSA-6784531|reactome:R-HSA-9609690|reactome:R-HSA-9610379|reactome:R-HSA-9615933 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/11/01 rogid:0ZRCHNVEmmtGEOASNwg3kIm2uys9606 rogid:eoj+tg9RAVKcVlT9ku1ozXCa3u89606 intact-crc:8E216454F46800F3|rigid:gx7W2dWGqMoA6e4mZ3ejWOlMHeM false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q13283 uniprotkb:Q4LE58 intact:EBI-1047359|intact:EBI-1384154|ensembl:ENSP00000348578|ensembl:ENSP00000377681|ensembl:ENSP00000430480|ensembl:ENSP00000502880|ensembl:ENSP00000503039|ensembl:ENSP00000503699|ensembl:ENSP00000503939|ensembl:ENSP00000504140|ensembl:ENSP00000504627|uniprotkb:Q5HYE9 intact:EBI-877750 psi-mi:g3bp1_human(display_long)|uniprotkb:G3BP1(gene name)|psi-mi:G3BP1(display_short)|uniprotkb:G3BP(gene name synonym)|uniprotkb:ATP-dependent DNA helicase VIII(gene name synonym)|uniprotkb:GAP SH3 domain-binding protein 1(gene name synonym) psi-mi:q4le58_human(display_long)|uniprotkb:EIF4G1 variant protein(gene name)|psi-mi:EIF4G1 variant protein(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514311|imex:IM-12079-90 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005745.1|refseq:NP_938405.1|ensembl:ENSG00000145907(gene)|go:"GO:0003729"(mRNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0033677"(DNA/RNA helicase activity)|go:"GO:0034063"(stress granule assembly)|go:"GO:0043204"(perikaryon)|go:"GO:0045087"(innate immune response)|go:"GO:0051607"(defense response to virus)|go:"GO:0062029"(positive regulation of stress granule assembly)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR002075(Nuclear transport factor 2)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR018222|interpro:IPR032710|interpro:IPR034374|interpro:IPR034375|interpro:IPR035979|interpro:IPR039539|mint:Q13283|ensembl:ENST00000356245(transcript)|rcsb pdb:3Q90|rcsb pdb:4FCJ|rcsb pdb:4FCM|rcsb pdb:4IIA|rcsb pdb:5FW5|rcsb pdb:6TA7|ensembl:ENST00000394123(transcript)|ensembl:ENST00000522761(transcript)|ensembl:ENST00000676827(transcript)|ensembl:ENST00000676978(transcript)|ensembl:ENST00000677323(transcript)|ensembl:ENST00000678070(transcript)|ensembl:ENST00000678101(transcript)|ensembl:ENST00000678925(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|refseq:XP_006714812.1|refseq:XP_006714813.1|refseq:XP_016864411.1|refseq:XP_016864412.1 go:"GO:0003729"(mRNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0008190"(eukaryotic initiation factor 4E binding)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR003307(eIF4-gamma/eIF5/eIF2-epsilon)|interpro:IPR003891(Initiation factor eIF-4 gamma, MA3)|interpro:IPR003890(MIF4G-like, type 3)|interpro:IPR037584|interpro:IPR016021(MIF4-like, type 1/2/3) psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/11/01 rogid:0ZRCHNVEmmtGEOASNwg3kIm2uys9606 rogid:Y/nGTcJwfFXWNRyAStOYrrJBojM9606 intact-crc:8E216454F46800F3|rigid:gx7W2dWGqMoA6e4mZ3ejWOlMHeM false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q13283 uniprotkb:Q9H6R4 intact:EBI-1047359|intact:EBI-1384154|ensembl:ENSP00000348578|ensembl:ENSP00000377681|ensembl:ENSP00000430480|ensembl:ENSP00000502880|ensembl:ENSP00000503039|ensembl:ENSP00000503699|ensembl:ENSP00000503939|ensembl:ENSP00000504140|ensembl:ENSP00000504627|uniprotkb:Q5HYE9 intact:EBI-2514288|ensembl:ENSP00000297990|uniprotkb:Q5T5M4|uniprotkb:Q8TEZ0|uniprotkb:Q8TEZ1|uniprotkb:Q8TEY9|uniprotkb:Q7L4G6|uniprotkb:Q5T5M3|uniprotkb:Q8N6I0|uniprotkb:Q9H675 psi-mi:g3bp1_human(display_long)|uniprotkb:G3BP1(gene name)|psi-mi:G3BP1(display_short)|uniprotkb:G3BP(gene name synonym)|uniprotkb:ATP-dependent DNA helicase VIII(gene name synonym)|uniprotkb:GAP SH3 domain-binding protein 1(gene name synonym) psi-mi:nol6_human(display_long)|uniprotkb:NOL6(gene name)|psi-mi:NOL6(display_short)|uniprotkb:Nucleolar RNA-associated protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514311|imex:IM-12079-90 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005745.1|refseq:NP_938405.1|ensembl:ENSG00000145907(gene)|go:"GO:0003729"(mRNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0033677"(DNA/RNA helicase activity)|go:"GO:0034063"(stress granule assembly)|go:"GO:0043204"(perikaryon)|go:"GO:0045087"(innate immune response)|go:"GO:0051607"(defense response to virus)|go:"GO:0062029"(positive regulation of stress granule assembly)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR002075(Nuclear transport factor 2)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR018222|interpro:IPR032710|interpro:IPR034374|interpro:IPR034375|interpro:IPR035979|interpro:IPR039539|mint:Q13283|ensembl:ENST00000356245(transcript)|rcsb pdb:3Q90|rcsb pdb:4FCJ|rcsb pdb:4FCM|rcsb pdb:4IIA|rcsb pdb:5FW5|rcsb pdb:6TA7|ensembl:ENST00000394123(transcript)|ensembl:ENST00000522761(transcript)|ensembl:ENST00000676827(transcript)|ensembl:ENST00000676978(transcript)|ensembl:ENST00000677323(transcript)|ensembl:ENST00000678070(transcript)|ensembl:ENST00000678101(transcript)|ensembl:ENST00000678925(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|refseq:XP_006714812.1|refseq:XP_006714813.1|refseq:XP_016864411.1|refseq:XP_016864412.1 ensembl:ENSG00000165271(gene)|ensembl:ENST00000297990(transcript)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005739"(mitochondrion)|go:"GO:0006364"(rRNA processing)|go:"GO:0006409"(tRNA export from nucleus)|go:"GO:0032040"(small-subunit processome)|go:"GO:0032545"(CURI complex)|go:"GO:0034456"(UTP-C complex)|interpro:IPR005554(Nrap protein)|interpro:IPR035082|interpro:IPR035367|interpro:IPR035368|interpro:IPR035369|interpro:IPR035370|interpro:IPR035371|mint:Q9H6R4|reactome:R-HSA-6790901|reactome:R-HSA-6791226|refseq:NP_075068.2|refseq:NP_631981.2 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/11/01 rogid:0ZRCHNVEmmtGEOASNwg3kIm2uys9606 rogid:e1Waxlhmq+KTKwHTV13aWEpVF4k9606 intact-crc:8E216454F46800F3|rigid:gx7W2dWGqMoA6e4mZ3ejWOlMHeM false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q13283 uniprotkb:Q13823 intact:EBI-1047359|intact:EBI-1384154|ensembl:ENSP00000348578|ensembl:ENSP00000377681|ensembl:ENSP00000430480|ensembl:ENSP00000502880|ensembl:ENSP00000503039|ensembl:ENSP00000503699|ensembl:ENSP00000503939|ensembl:ENSP00000504140|ensembl:ENSP00000504627|uniprotkb:Q5HYE9 intact:EBI-1043365|uniprotkb:Q9BWN7|ensembl:ENSP00000362153 psi-mi:g3bp1_human(display_long)|uniprotkb:G3BP1(gene name)|psi-mi:G3BP1(display_short)|uniprotkb:G3BP(gene name synonym)|uniprotkb:ATP-dependent DNA helicase VIII(gene name synonym)|uniprotkb:GAP SH3 domain-binding protein 1(gene name synonym) psi-mi:nog2_human(display_long)|uniprotkb:Autoantigen NGP-1(gene name synonym)|uniprotkb:GNL2(gene name)|psi-mi:GNL2(display_short)|uniprotkb:NGP1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514311|imex:IM-12079-90 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005745.1|refseq:NP_938405.1|ensembl:ENSG00000145907(gene)|go:"GO:0003729"(mRNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0033677"(DNA/RNA helicase activity)|go:"GO:0034063"(stress granule assembly)|go:"GO:0043204"(perikaryon)|go:"GO:0045087"(innate immune response)|go:"GO:0051607"(defense response to virus)|go:"GO:0062029"(positive regulation of stress granule assembly)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR002075(Nuclear transport factor 2)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR018222|interpro:IPR032710|interpro:IPR034374|interpro:IPR034375|interpro:IPR035979|interpro:IPR039539|mint:Q13283|ensembl:ENST00000356245(transcript)|rcsb pdb:3Q90|rcsb pdb:4FCJ|rcsb pdb:4FCM|rcsb pdb:4IIA|rcsb pdb:5FW5|rcsb pdb:6TA7|ensembl:ENST00000394123(transcript)|ensembl:ENST00000522761(transcript)|ensembl:ENST00000676827(transcript)|ensembl:ENST00000676978(transcript)|ensembl:ENST00000677323(transcript)|ensembl:ENST00000678070(transcript)|ensembl:ENST00000678101(transcript)|ensembl:ENST00000678925(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|refseq:XP_006714812.1|refseq:XP_006714813.1|refseq:XP_016864411.1|refseq:XP_016864412.1 ensembl:ENSG00000134697(gene)|ensembl:ENST00000373062(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0016020"(membrane)|go:"GO:0042254"(ribosome biogenesis)|interpro:IPR006073(GTP1/OBG)|interpro:IPR012971(NGP1, N-terminal)|interpro:IPR023179|interpro:IPR024929|interpro:IPR027417|interpro:IPR030378|mint:Q13823|rcsb pdb:6LSS|rcsb pdb:6LU8|refseq:NP_037417.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/11/01 rogid:0ZRCHNVEmmtGEOASNwg3kIm2uys9606 rogid:CgIg/QNhk71SHIhV4iLvIuC/HUo9606 intact-crc:8E216454F46800F3|rigid:gx7W2dWGqMoA6e4mZ3ejWOlMHeM false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q13283 uniprotkb:Q7Z417 intact:EBI-1047359|intact:EBI-1384154|ensembl:ENSP00000348578|ensembl:ENSP00000377681|ensembl:ENSP00000430480|ensembl:ENSP00000502880|ensembl:ENSP00000503039|ensembl:ENSP00000503699|ensembl:ENSP00000503939|ensembl:ENSP00000504140|ensembl:ENSP00000504627|uniprotkb:Q5HYE9 intact:EBI-1210753|intact:EBI-10172018|uniprotkb:A1L3A7|uniprotkb:Q9P2M5|uniprotkb:A1L3A6|ensembl:ENSP00000225388 psi-mi:g3bp1_human(display_long)|uniprotkb:G3BP1(gene name)|psi-mi:G3BP1(display_short)|uniprotkb:G3BP(gene name synonym)|uniprotkb:ATP-dependent DNA helicase VIII(gene name synonym)|uniprotkb:GAP SH3 domain-binding protein 1(gene name synonym) psi-mi:nufp2_human(display_long)|uniprotkb:NUFIP2(gene name)|psi-mi:NUFIP2(display_short)|uniprotkb:KIAA1321(gene name synonym)|uniprotkb:PIG1(orf name)|uniprotkb:FMRP-interacting protein 2(gene name synonym)|uniprotkb:82 kDa FMRP-interacting protein(gene name synonym)|uniprotkb:Cell proliferation-inducing gene 1 protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514311|imex:IM-12079-90 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005745.1|refseq:NP_938405.1|ensembl:ENSG00000145907(gene)|go:"GO:0003729"(mRNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0033677"(DNA/RNA helicase activity)|go:"GO:0034063"(stress granule assembly)|go:"GO:0043204"(perikaryon)|go:"GO:0045087"(innate immune response)|go:"GO:0051607"(defense response to virus)|go:"GO:0062029"(positive regulation of stress granule assembly)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR002075(Nuclear transport factor 2)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR018222|interpro:IPR032710|interpro:IPR034374|interpro:IPR034375|interpro:IPR035979|interpro:IPR039539|mint:Q13283|ensembl:ENST00000356245(transcript)|rcsb pdb:3Q90|rcsb pdb:4FCJ|rcsb pdb:4FCM|rcsb pdb:4IIA|rcsb pdb:5FW5|rcsb pdb:6TA7|ensembl:ENST00000394123(transcript)|ensembl:ENST00000522761(transcript)|ensembl:ENST00000676827(transcript)|ensembl:ENST00000676978(transcript)|ensembl:ENST00000677323(transcript)|ensembl:ENST00000678070(transcript)|ensembl:ENST00000678101(transcript)|ensembl:ENST00000678925(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|refseq:XP_006714812.1|refseq:XP_006714813.1|refseq:XP_016864411.1|refseq:XP_016864412.1 refseq:NP_065823.1|dip:DIP-29023N|ensembl:ENSG00000108256(gene)|ensembl:ENST00000225388(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016020"(membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0042788"(polysomal ribosome)|interpro:IPR032747|mint:Q7Z417 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/11/01 rogid:0ZRCHNVEmmtGEOASNwg3kIm2uys9606 rogid:zdbkRisveP+8g70umfbEPHTnAgk9606 intact-crc:8E216454F46800F3|rigid:gx7W2dWGqMoA6e4mZ3ejWOlMHeM false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q13283 uniprotkb:Q8IX18 intact:EBI-1047359|intact:EBI-1384154|ensembl:ENSP00000348578|ensembl:ENSP00000377681|ensembl:ENSP00000430480|ensembl:ENSP00000502880|ensembl:ENSP00000503039|ensembl:ENSP00000503699|ensembl:ENSP00000503939|ensembl:ENSP00000504140|ensembl:ENSP00000504627|uniprotkb:Q5HYE9 intact:EBI-2514301|ensembl:ENSP00000251241|uniprotkb:B3KTJ5|uniprotkb:Q5JPH4|uniprotkb:Q8WY53|uniprotkb:Q8TC86|uniprotkb:Q9BXM1|uniprotkb:Q9H6M9|uniprotkb:C9JR60 psi-mi:g3bp1_human(display_long)|uniprotkb:G3BP1(gene name)|psi-mi:G3BP1(display_short)|uniprotkb:G3BP(gene name synonym)|uniprotkb:ATP-dependent DNA helicase VIII(gene name synonym)|uniprotkb:GAP SH3 domain-binding protein 1(gene name synonym) psi-mi:dhx40_human(display_long)|uniprotkb:DHX40(gene name)|psi-mi:DHX40(display_short)|uniprotkb:DDX40(gene name synonym)|uniprotkb:DEAH box protein 40(gene name synonym)|uniprotkb:Protein PAD(gene name synonym)|uniprotkb:ARG147(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514311|imex:IM-12079-90 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005745.1|refseq:NP_938405.1|ensembl:ENSG00000145907(gene)|go:"GO:0003729"(mRNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0033677"(DNA/RNA helicase activity)|go:"GO:0034063"(stress granule assembly)|go:"GO:0043204"(perikaryon)|go:"GO:0045087"(innate immune response)|go:"GO:0051607"(defense response to virus)|go:"GO:0062029"(positive regulation of stress granule assembly)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR002075(Nuclear transport factor 2)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR018222|interpro:IPR032710|interpro:IPR034374|interpro:IPR034375|interpro:IPR035979|interpro:IPR039539|mint:Q13283|ensembl:ENST00000356245(transcript)|rcsb pdb:3Q90|rcsb pdb:4FCJ|rcsb pdb:4FCM|rcsb pdb:4IIA|rcsb pdb:5FW5|rcsb pdb:6TA7|ensembl:ENST00000394123(transcript)|ensembl:ENST00000522761(transcript)|ensembl:ENST00000676827(transcript)|ensembl:ENST00000676978(transcript)|ensembl:ENST00000677323(transcript)|ensembl:ENST00000678070(transcript)|ensembl:ENST00000678101(transcript)|ensembl:ENST00000678925(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|refseq:XP_006714812.1|refseq:XP_006714813.1|refseq:XP_016864411.1|refseq:XP_016864412.1 ensembl:ENSG00000108406(gene)|ensembl:ENST00000251241(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR002464(DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site)|interpro:IPR007502(Helicase-associated region)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR011709(Region of unknown function DUF1605)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR027417|refseq:NP_001159773.1|refseq:NP_078888.4 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/11/01 rogid:0ZRCHNVEmmtGEOASNwg3kIm2uys9606 rogid:jOdFhOZTjeXlSYf6zzKi/EiizXY9606 intact-crc:8E216454F46800F3|rigid:gx7W2dWGqMoA6e4mZ3ejWOlMHeM false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q13283 uniprotkb:Q9Y5J1 intact:EBI-1047359|intact:EBI-1384154|ensembl:ENSP00000348578|ensembl:ENSP00000377681|ensembl:ENSP00000430480|ensembl:ENSP00000502880|ensembl:ENSP00000503039|ensembl:ENSP00000503699|ensembl:ENSP00000503939|ensembl:ENSP00000504140|ensembl:ENSP00000504627|uniprotkb:Q5HYE9 intact:EBI-592816|uniprotkb:Q9H4N6|ensembl:ENSP00000225298 psi-mi:g3bp1_human(display_long)|uniprotkb:G3BP1(gene name)|psi-mi:G3BP1(display_short)|uniprotkb:G3BP(gene name synonym)|uniprotkb:ATP-dependent DNA helicase VIII(gene name synonym)|uniprotkb:GAP SH3 domain-binding protein 1(gene name synonym) psi-mi:utp18_human(display_long)|uniprotkb:WD repeat-containing protein 50(gene name synonym)|uniprotkb:UTP18(gene name)|psi-mi:UTP18(display_short)|uniprotkb:CGI-48(orf name)|uniprotkb:CDABP0061(orf name)|uniprotkb:WDR50(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514311|imex:IM-12079-90 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005745.1|refseq:NP_938405.1|ensembl:ENSG00000145907(gene)|go:"GO:0003729"(mRNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0033677"(DNA/RNA helicase activity)|go:"GO:0034063"(stress granule assembly)|go:"GO:0043204"(perikaryon)|go:"GO:0045087"(innate immune response)|go:"GO:0051607"(defense response to virus)|go:"GO:0062029"(positive regulation of stress granule assembly)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR002075(Nuclear transport factor 2)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR018222|interpro:IPR032710|interpro:IPR034374|interpro:IPR034375|interpro:IPR035979|interpro:IPR039539|mint:Q13283|ensembl:ENST00000356245(transcript)|rcsb pdb:3Q90|rcsb pdb:4FCJ|rcsb pdb:4FCM|rcsb pdb:4IIA|rcsb pdb:5FW5|rcsb pdb:6TA7|ensembl:ENST00000394123(transcript)|ensembl:ENST00000522761(transcript)|ensembl:ENST00000676827(transcript)|ensembl:ENST00000676978(transcript)|ensembl:ENST00000677323(transcript)|ensembl:ENST00000678070(transcript)|ensembl:ENST00000678101(transcript)|ensembl:ENST00000678925(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|refseq:XP_006714812.1|refseq:XP_006714813.1|refseq:XP_016864411.1|refseq:XP_016864412.1 refseq:NP_057085.2|ensembl:ENSG00000011260(gene)|ensembl:ENST00000225298(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006364"(rRNA processing)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032040"(small-subunit processome)|go:"GO:0034388"(Pwp2p-containing subcomplex of 90S preribosome)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|mint:Q9Y5J1|reactome:R-HSA-6790901|reactome:R-HSA-6791226 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/11/01 rogid:0ZRCHNVEmmtGEOASNwg3kIm2uys9606 rogid:l873IUyfCql4N9VelHPuUEqpzRY9606 intact-crc:8E216454F46800F3|rigid:gx7W2dWGqMoA6e4mZ3ejWOlMHeM false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q13283 uniprotkb:Q9BYJ9 intact:EBI-1047359|intact:EBI-1384154|ensembl:ENSP00000348578|ensembl:ENSP00000377681|ensembl:ENSP00000430480|ensembl:ENSP00000502880|ensembl:ENSP00000503039|ensembl:ENSP00000503699|ensembl:ENSP00000503939|ensembl:ENSP00000504140|ensembl:ENSP00000504627|uniprotkb:Q5HYE9 intact:EBI-1051237|uniprotkb:Q8N3G5|uniprotkb:Q8TBT1|uniprotkb:Q96AN4|uniprotkb:Q96S57|uniprotkb:Q9BTI7|uniprotkb:Q9NX79|ensembl:ENSP00000359364 psi-mi:g3bp1_human(display_long)|uniprotkb:G3BP1(gene name)|psi-mi:G3BP1(display_short)|uniprotkb:G3BP(gene name synonym)|uniprotkb:ATP-dependent DNA helicase VIII(gene name synonym)|uniprotkb:GAP SH3 domain-binding protein 1(gene name synonym) psi-mi:ythd1_human(display_long)|uniprotkb:Dermatomyositis associated with cancer putative autoantigen 1(gene name synonym)|uniprotkb:YTHDF1(gene name)|psi-mi:YTHDF1(display_short)|uniprotkb:C20orf21(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514311|imex:IM-12079-90 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005745.1|refseq:NP_938405.1|ensembl:ENSG00000145907(gene)|go:"GO:0003729"(mRNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0033677"(DNA/RNA helicase activity)|go:"GO:0034063"(stress granule assembly)|go:"GO:0043204"(perikaryon)|go:"GO:0045087"(innate immune response)|go:"GO:0051607"(defense response to virus)|go:"GO:0062029"(positive regulation of stress granule assembly)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR002075(Nuclear transport factor 2)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR018222|interpro:IPR032710|interpro:IPR034374|interpro:IPR034375|interpro:IPR035979|interpro:IPR039539|mint:Q13283|ensembl:ENST00000356245(transcript)|rcsb pdb:3Q90|rcsb pdb:4FCJ|rcsb pdb:4FCM|rcsb pdb:4IIA|rcsb pdb:5FW5|rcsb pdb:6TA7|ensembl:ENST00000394123(transcript)|ensembl:ENST00000522761(transcript)|ensembl:ENST00000676827(transcript)|ensembl:ENST00000676978(transcript)|ensembl:ENST00000677323(transcript)|ensembl:ENST00000678070(transcript)|ensembl:ENST00000678101(transcript)|ensembl:ENST00000678925(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|refseq:XP_006714812.1|refseq:XP_006714813.1|refseq:XP_016864411.1|refseq:XP_016864412.1 refseq:NP_060268.2|ensembl:ENSG00000149658(gene)|ensembl:ENST00000370339(transcript)|go:"GO:0000932"(P-body)|go:"GO:0002376"(immune system process)|go:"GO:0002577"(regulation of antigen processing and presentation)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0034063"(stress granule assembly)|go:"GO:0043022"(ribosome binding)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0061157"(mRNA destabilization)|go:"GO:0070925"(organelle assembly)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1902667"(regulation of axon guidance)|go:"GO:1990247"(N6-methyladenosine-containing RNA binding)|interpro:IPR007275(YT521-B-like protein)|mint:Q9BYJ9|rcsb pdb:4RCI|rcsb pdb:4RCJ psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/11/01 rogid:0ZRCHNVEmmtGEOASNwg3kIm2uys9606 rogid:uzNKPfwF7I+6hLk6l8iiDOhuBcQ9606 intact-crc:8E216454F46800F3|rigid:gx7W2dWGqMoA6e4mZ3ejWOlMHeM false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q13283 uniprotkb:O75369 intact:EBI-1047359|intact:EBI-1384154|ensembl:ENSP00000348578|ensembl:ENSP00000377681|ensembl:ENSP00000430480|ensembl:ENSP00000502880|ensembl:ENSP00000503039|ensembl:ENSP00000503699|ensembl:ENSP00000503939|ensembl:ENSP00000504140|ensembl:ENSP00000504627|uniprotkb:Q5HYE9 intact:EBI-352089|intact:EBI-1754974|uniprotkb:Q13706|uniprotkb:Q59EC2|uniprotkb:Q6MZJ1|uniprotkb:Q8WXS9|uniprotkb:Q8WXT0|uniprotkb:Q8WXT1|uniprotkb:Q8WXT2|uniprotkb:Q9NRB5|uniprotkb:B2ZZ84|uniprotkb:Q9NT26|uniprotkb:Q9UEV9|intact:EBI-1960054|uniprotkb:C9JKE6|uniprotkb:B2ZZ85|uniprotkb:C9JMC4|ensembl:ENSP00000295956|uniprotkb:B2ZZ83|uniprotkb:Q60FE7|uniprotkb:Q8WXT3 psi-mi:g3bp1_human(display_long)|uniprotkb:G3BP1(gene name)|psi-mi:G3BP1(display_short)|uniprotkb:G3BP(gene name synonym)|uniprotkb:ATP-dependent DNA helicase VIII(gene name synonym)|uniprotkb:GAP SH3 domain-binding protein 1(gene name synonym) psi-mi:flnb_human(display_long)|uniprotkb:FLNB(gene name)|psi-mi:FLNB(display_short)|uniprotkb:FLN1L(gene name synonym)|uniprotkb:FLN3(gene name synonym)|uniprotkb:TABP(gene name synonym)|uniprotkb:TAP(gene name synonym)|uniprotkb:Beta-filamin(gene name synonym)|uniprotkb:Actin-binding-like protein(gene name synonym)|uniprotkb:Thyroid autoantigen(gene name synonym)|uniprotkb:Truncated actin-binding protein(gene name synonym)|uniprotkb:ABP-280 homolog(gene name synonym)|uniprotkb:ABP-278(gene name synonym)|uniprotkb:Filamin-3(gene name synonym)|uniprotkb:Filamin homolog 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514311|imex:IM-12079-90 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005745.1|refseq:NP_938405.1|ensembl:ENSG00000145907(gene)|go:"GO:0003729"(mRNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0033677"(DNA/RNA helicase activity)|go:"GO:0034063"(stress granule assembly)|go:"GO:0043204"(perikaryon)|go:"GO:0045087"(innate immune response)|go:"GO:0051607"(defense response to virus)|go:"GO:0062029"(positive regulation of stress granule assembly)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR002075(Nuclear transport factor 2)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR018222|interpro:IPR032710|interpro:IPR034374|interpro:IPR034375|interpro:IPR035979|interpro:IPR039539|mint:Q13283|ensembl:ENST00000356245(transcript)|rcsb pdb:3Q90|rcsb pdb:4FCJ|rcsb pdb:4FCM|rcsb pdb:4IIA|rcsb pdb:5FW5|rcsb pdb:6TA7|ensembl:ENST00000394123(transcript)|ensembl:ENST00000522761(transcript)|ensembl:ENST00000676827(transcript)|ensembl:ENST00000676978(transcript)|ensembl:ENST00000677323(transcript)|ensembl:ENST00000678070(transcript)|ensembl:ENST00000678101(transcript)|ensembl:ENST00000678925(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|refseq:XP_006714812.1|refseq:XP_006714813.1|refseq:XP_016864411.1|refseq:XP_016864412.1 refseq:NP_001157791.1|refseq:NP_001448.2|go:"GO:0003334"(keratinocyte development)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0003723"(RNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0007165"(signal transduction)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030018"(Z disc)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045296"(cadherin binding)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0051015"(actin filament binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071346"(cellular response to interferon-gamma)|interpro:IPR001298(Filamin/ABP280 repeat)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017868|interpro:IPR029874|interpro:IPR036872|interpro:IPR044801|mint:O75369|rcsb pdb:2DI8|rcsb pdb:2DI9|rcsb pdb:2DIA|rcsb pdb:2DIB|rcsb pdb:2DIC|rcsb pdb:2DJ4|rcsb pdb:2DLG|rcsb pdb:2DMB|rcsb pdb:2DMC|rcsb pdb:2E9I|rcsb pdb:2E9J|rcsb pdb:2EE6|rcsb pdb:2EE9|rcsb pdb:2EEA|rcsb pdb:2EEB|rcsb pdb:2EEC|rcsb pdb:2EED|rcsb pdb:2WA5|rcsb pdb:2WA6|rcsb pdb:2WA7|rcsb pdb:3FER|rcsb pdb:4B7L|rcsb pdb:5DCP|reactome:R-HSA-1169408|ensembl:ENSG00000136068(gene)|ensembl:ENST00000295956(transcript)|go:"GO:0001725"(stress fiber)|refseq:NP_001157789.1|refseq:NP_001157790.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/11/01 rogid:0ZRCHNVEmmtGEOASNwg3kIm2uys9606 rogid:lsf6C/Vg0io7UhUi1Kapgwp0p5E9606 intact-crc:8E216454F46800F3|rigid:gx7W2dWGqMoA6e4mZ3ejWOlMHeM false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q13283 uniprotkb:Q14694 intact:EBI-1047359|intact:EBI-1384154|ensembl:ENSP00000348578|ensembl:ENSP00000377681|ensembl:ENSP00000430480|ensembl:ENSP00000502880|ensembl:ENSP00000503039|ensembl:ENSP00000503699|ensembl:ENSP00000503939|ensembl:ENSP00000504140|ensembl:ENSP00000504627|uniprotkb:Q5HYE9 intact:EBI-2510389|uniprotkb:B4DS84|uniprotkb:B2RDJ8|uniprotkb:Q9BWG7|uniprotkb:Q9NSL7|ensembl:ENSP00000219473 psi-mi:g3bp1_human(display_long)|uniprotkb:G3BP1(gene name)|psi-mi:G3BP1(display_short)|uniprotkb:G3BP(gene name synonym)|uniprotkb:ATP-dependent DNA helicase VIII(gene name synonym)|uniprotkb:GAP SH3 domain-binding protein 1(gene name synonym) psi-mi:ubp10_human(display_long)|uniprotkb:USP10(gene name)|psi-mi:USP10(display_short)|uniprotkb:KIAA0190(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 10(gene name synonym)|uniprotkb:Deubiquitinating enzyme 10(gene name synonym)|uniprotkb:Ubiquitin thioesterase 10(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514311|imex:IM-12079-90 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005745.1|refseq:NP_938405.1|ensembl:ENSG00000145907(gene)|go:"GO:0003729"(mRNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0033677"(DNA/RNA helicase activity)|go:"GO:0034063"(stress granule assembly)|go:"GO:0043204"(perikaryon)|go:"GO:0045087"(innate immune response)|go:"GO:0051607"(defense response to virus)|go:"GO:0062029"(positive regulation of stress granule assembly)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR002075(Nuclear transport factor 2)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR018222|interpro:IPR032710|interpro:IPR034374|interpro:IPR034375|interpro:IPR035979|interpro:IPR039539|mint:Q13283|ensembl:ENST00000356245(transcript)|rcsb pdb:3Q90|rcsb pdb:4FCJ|rcsb pdb:4FCM|rcsb pdb:4IIA|rcsb pdb:5FW5|rcsb pdb:6TA7|ensembl:ENST00000394123(transcript)|ensembl:ENST00000522761(transcript)|ensembl:ENST00000676827(transcript)|ensembl:ENST00000676978(transcript)|ensembl:ENST00000677323(transcript)|ensembl:ENST00000678070(transcript)|ensembl:ENST00000678101(transcript)|ensembl:ENST00000678925(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|refseq:XP_006714812.1|refseq:XP_006714813.1|refseq:XP_016864411.1|refseq:XP_016864412.1 refseq:NP_005144.2|ensembl:ENSP00000219473|ensembl:ENST00000570191|ensembl:ENSP00000457411|refseq:NP_001259004.1|ensembl:ENSG00000103194(gene)|ensembl:ENST00000219473(transcript)|go:"GO:0002039"(p53 binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006914"(autophagy)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019985"(translesion synthesis)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0071347"(cellular response to interleukin-1)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR009818(Ataxin-2, C-terminal)|interpro:IPR018200|interpro:IPR028767|interpro:IPR028889|interpro:IPR038765|mint:Q14694|reactome:R-HSA-5656169|reactome:R-HSA-5689880|go:"GO:0005737"(cytoplasm) psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/11/01 rogid:0ZRCHNVEmmtGEOASNwg3kIm2uys9606 rogid:W34ZdOIilLOVI8SXqCH3rOmmloo9606 intact-crc:8E216454F46800F3|rigid:gx7W2dWGqMoA6e4mZ3ejWOlMHeM false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q13283 uniprotkb:P21333 intact:EBI-1047359|intact:EBI-1384154|ensembl:ENSP00000348578|ensembl:ENSP00000377681|ensembl:ENSP00000430480|ensembl:ENSP00000502880|ensembl:ENSP00000503039|ensembl:ENSP00000503699|ensembl:ENSP00000503939|ensembl:ENSP00000504140|ensembl:ENSP00000504627|uniprotkb:Q5HYE9 intact:EBI-350432|uniprotkb:Q8NF52|intact:EBI-1103234|ensembl:ENSP00000358866|uniprotkb:Q5HY53|uniprotkb:Q5HY55|uniprotkb:E9KL45 psi-mi:g3bp1_human(display_long)|uniprotkb:G3BP1(gene name)|psi-mi:G3BP1(display_short)|uniprotkb:G3BP(gene name synonym)|uniprotkb:ATP-dependent DNA helicase VIII(gene name synonym)|uniprotkb:GAP SH3 domain-binding protein 1(gene name synonym) psi-mi:flna_human(display_long)|uniprotkb:FLNA(gene name)|psi-mi:FLNA(display_short)|uniprotkb:FLN(gene name synonym)|uniprotkb:FLN1(gene name synonym)|uniprotkb:Alpha-filamin(gene name synonym)|uniprotkb:Filamin-1(gene name synonym)|uniprotkb:Endothelial actin-binding protein(gene name synonym)|uniprotkb:Actin-binding protein 280(gene name synonym)|uniprotkb:Non-muscle filamin(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514311|imex:IM-12079-90 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005745.1|refseq:NP_938405.1|ensembl:ENSG00000145907(gene)|go:"GO:0003729"(mRNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0033677"(DNA/RNA helicase activity)|go:"GO:0034063"(stress granule assembly)|go:"GO:0043204"(perikaryon)|go:"GO:0045087"(innate immune response)|go:"GO:0051607"(defense response to virus)|go:"GO:0062029"(positive regulation of stress granule assembly)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR002075(Nuclear transport factor 2)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR018222|interpro:IPR032710|interpro:IPR034374|interpro:IPR034375|interpro:IPR035979|interpro:IPR039539|mint:Q13283|ensembl:ENST00000356245(transcript)|rcsb pdb:3Q90|rcsb pdb:4FCJ|rcsb pdb:4FCM|rcsb pdb:4IIA|rcsb pdb:5FW5|rcsb pdb:6TA7|ensembl:ENST00000394123(transcript)|ensembl:ENST00000522761(transcript)|ensembl:ENST00000676827(transcript)|ensembl:ENST00000676978(transcript)|ensembl:ENST00000677323(transcript)|ensembl:ENST00000678070(transcript)|ensembl:ENST00000678101(transcript)|ensembl:ENST00000678925(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|refseq:XP_006714812.1|refseq:XP_006714813.1|refseq:XP_016864411.1|refseq:XP_016864412.1 go:"GO:0007195"(adenylate cyclase-inhibiting dopamine receptor signaling pathway)|go:"GO:1902396"(protein localization to bicellular tight junction)|refseq:NP_001104026.1|refseq:NP_001447.2|ensembl:ENSG00000196924(gene)|ensembl:ENST00000369850(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003723"(RNA binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048680"(positive regulation of axon regeneration)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051015"(actin filament binding)|go:"GO:0051020"(GTPase binding)|go:"GO:0051220"(cytoplasmic sequestering of protein)|go:"GO:0051764"(actin crosslink formation)|go:"GO:0060271"(cilium assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:0071526"(semaphorin-plexin signaling pathway)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090042"(tubulin deacetylation)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:0097368"(establishment of Sertoli cell barrier)|go:"GO:0097440"(apical dendrite)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1901381"(positive regulation of potassium ion transmembrane transport)|go:"GO:0046332"(SMAD binding)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016479"(negative regulation of transcription by RNA polymerase I)|go:"GO:0019900"(kinase binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0021943"(formation of radial glial scaffolds)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030018"(Z disc)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031523"(Myb complex)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031852"(mu-type opioid receptor binding)|go:"GO:0032233"(positive regulation of actin filament bundle assembly)|go:"GO:0032432"(actin filament bundle)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0034988"(Fc-gamma receptor I complex binding)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043113"(receptor clustering)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044319"(wound healing, spreading of cells)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0045296"(cadherin binding)|reactome:R-HSA-114608|reactome:R-HSA-430116|reactome:R-HSA-446353|reactome:R-HSA-5627123|reactome:R-HSA-8983711|rcsb pdb:6EW1|go:"GO:1905031"(regulation of membrane repolarization during cardiac muscle cell action potential)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2001046"(positive regulation of integrin-mediated signaling pathway)|go:"GO:2001224"(positive regulation of neuron migration)|interpro:IPR001298(Filamin/ABP280 repeat)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017868|interpro:IPR036872|interpro:IPR044801|mint:P21333|rcsb pdb:2AAV|rcsb pdb:2BP3|rcsb pdb:2BRQ|rcsb pdb:2J3S|rcsb pdb:2JF1|rcsb pdb:2K3T|rcsb pdb:2K7P|rcsb pdb:2K7Q|rcsb pdb:2MTP|rcsb pdb:2W0P|rcsb pdb:2WFN|rcsb pdb:3CNK|rcsb pdb:3HOC|rcsb pdb:3HOP|rcsb pdb:3HOR|rcsb pdb:3ISW|rcsb pdb:3RGH|rcsb pdb:4M9P|rcsb pdb:4P3W|rcsb pdb:5XR1|rcsb pdb:6D8C|go:"GO:1905000"(regulation of membrane repolarization during atrial cardiac muscle cell action potential)|dip:DIP-1136N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/11/01 rogid:0ZRCHNVEmmtGEOASNwg3kIm2uys9606 rogid:ZxGK5OSMy8cNsyt7Ax2KXb8bn9M9606 intact-crc:8E216454F46800F3|rigid:gx7W2dWGqMoA6e4mZ3ejWOlMHeM false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q13283 uniprotkb:Q8IXW5 intact:EBI-1047359|intact:EBI-1384154|ensembl:ENSP00000348578|ensembl:ENSP00000377681|ensembl:ENSP00000430480|ensembl:ENSP00000502880|ensembl:ENSP00000503039|ensembl:ENSP00000503699|ensembl:ENSP00000503939|ensembl:ENSP00000504140|ensembl:ENSP00000504627|uniprotkb:Q5HYE9 intact:EBI-395878|uniprotkb:Q49AS7|uniprotkb:Q9H8Y2|ensembl:ENSP00000476948|uniprotkb:C9JKB5 psi-mi:g3bp1_human(display_long)|uniprotkb:G3BP1(gene name)|psi-mi:G3BP1(display_short)|uniprotkb:G3BP(gene name synonym)|uniprotkb:ATP-dependent DNA helicase VIII(gene name synonym)|uniprotkb:GAP SH3 domain-binding protein 1(gene name synonym) psi-mi:rpap2_human(display_long)|uniprotkb:RPAP2(gene name)|psi-mi:RPAP2(display_short)|uniprotkb:C1orf82(gene name synonym)|uniprotkb:RNA polymerase II-associated protein 2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514311|imex:IM-12079-90 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005745.1|refseq:NP_938405.1|ensembl:ENSG00000145907(gene)|go:"GO:0003729"(mRNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0033677"(DNA/RNA helicase activity)|go:"GO:0034063"(stress granule assembly)|go:"GO:0043204"(perikaryon)|go:"GO:0045087"(innate immune response)|go:"GO:0051607"(defense response to virus)|go:"GO:0062029"(positive regulation of stress granule assembly)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR002075(Nuclear transport factor 2)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR018222|interpro:IPR032710|interpro:IPR034374|interpro:IPR034375|interpro:IPR035979|interpro:IPR039539|mint:Q13283|ensembl:ENST00000356245(transcript)|rcsb pdb:3Q90|rcsb pdb:4FCJ|rcsb pdb:4FCM|rcsb pdb:4IIA|rcsb pdb:5FW5|rcsb pdb:6TA7|ensembl:ENST00000394123(transcript)|ensembl:ENST00000522761(transcript)|ensembl:ENST00000676827(transcript)|ensembl:ENST00000676978(transcript)|ensembl:ENST00000677323(transcript)|ensembl:ENST00000678070(transcript)|ensembl:ENST00000678101(transcript)|ensembl:ENST00000678925(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|refseq:XP_006714812.1|refseq:XP_006714813.1|refseq:XP_016864411.1|refseq:XP_016864412.1 refseq:NP_079089.2|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008420"(RNA polymerase II CTD heptapeptide repeat phosphatase activity)|go:"GO:0009301"(snRNA transcription)|go:"GO:0016591"(RNA polymerase II, holoenzyme)|go:"GO:0043175"(RNA polymerase core enzyme binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0070940"(dephosphorylation of RNA polymerase II C-terminal domain)|go:"GO:0106306"|go:"GO:0106307"|interpro:IPR007308(Protein of unknown function DUF408)|interpro:IPR038534|interpro:IPR039693|mint:Q8IXW5|rcsb pdb:7B7U|reactome:R-HSA-6807505|ensembl:ENSG00000122484(gene)|ensembl:ENST00000610020(transcript)|go:"GO:0005634"(nucleus)|dip:DIP-32939N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/11/01 rogid:0ZRCHNVEmmtGEOASNwg3kIm2uys9606 rogid:niEFEvqkASycxkzfe9TYJuerUuY9606 intact-crc:8E216454F46800F3|rigid:gx7W2dWGqMoA6e4mZ3ejWOlMHeM false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q13283 uniprotkb:Q8N9T8 intact:EBI-1047359|intact:EBI-1384154|ensembl:ENSP00000348578|ensembl:ENSP00000377681|ensembl:ENSP00000430480|ensembl:ENSP00000502880|ensembl:ENSP00000503039|ensembl:ENSP00000503699|ensembl:ENSP00000503939|ensembl:ENSP00000504140|ensembl:ENSP00000504627|uniprotkb:Q5HYE9 intact:EBI-724923|uniprotkb:Q2M1R5|uniprotkb:Q2M1R7|uniprotkb:Q7L5J7|uniprotkb:Q96G92|uniprotkb:Q9BU50|uniprotkb:Q9H6I1|uniprotkb:Q9H978|ensembl:ENSP00000320917 psi-mi:g3bp1_human(display_long)|uniprotkb:G3BP1(gene name)|psi-mi:G3BP1(display_short)|uniprotkb:G3BP(gene name synonym)|uniprotkb:ATP-dependent DNA helicase VIII(gene name synonym)|uniprotkb:GAP SH3 domain-binding protein 1(gene name synonym) psi-mi:kri1_human(display_long)|uniprotkb:KRI1(gene name)|psi-mi:KRI1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514311|imex:IM-12079-90 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005745.1|refseq:NP_938405.1|ensembl:ENSG00000145907(gene)|go:"GO:0003729"(mRNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0033677"(DNA/RNA helicase activity)|go:"GO:0034063"(stress granule assembly)|go:"GO:0043204"(perikaryon)|go:"GO:0045087"(innate immune response)|go:"GO:0051607"(defense response to virus)|go:"GO:0062029"(positive regulation of stress granule assembly)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR002075(Nuclear transport factor 2)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR018222|interpro:IPR032710|interpro:IPR034374|interpro:IPR034375|interpro:IPR035979|interpro:IPR039539|mint:Q13283|ensembl:ENST00000356245(transcript)|rcsb pdb:3Q90|rcsb pdb:4FCJ|rcsb pdb:4FCM|rcsb pdb:4IIA|rcsb pdb:5FW5|rcsb pdb:6TA7|ensembl:ENST00000394123(transcript)|ensembl:ENST00000522761(transcript)|ensembl:ENST00000676827(transcript)|ensembl:ENST00000676978(transcript)|ensembl:ENST00000677323(transcript)|ensembl:ENST00000678070(transcript)|ensembl:ENST00000678101(transcript)|ensembl:ENST00000678925(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|refseq:XP_006714812.1|refseq:XP_006714813.1|refseq:XP_016864411.1|refseq:XP_016864412.1 refseq:NP_075384.3|ensembl:ENSG00000129347(gene)|ensembl:ENST00000312962(transcript)|go:"GO:0000447"("endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0003723"(RNA binding)|go:"GO:0005730"(nucleolus)|go:"GO:0030686"(90S preribosome)|interpro:IPR018034|interpro:IPR024626|mint:Q8N9T8 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/11/01 rogid:0ZRCHNVEmmtGEOASNwg3kIm2uys9606 rogid:sIRmrP/c3tSmEAj1usRGN3R3Bh09606 intact-crc:8E216454F46800F3|rigid:gx7W2dWGqMoA6e4mZ3ejWOlMHeM false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q13283 uniprotkb:Q6FI13 intact:EBI-1047359|intact:EBI-1384154|ensembl:ENSP00000348578|ensembl:ENSP00000377681|ensembl:ENSP00000430480|ensembl:ENSP00000502880|ensembl:ENSP00000503039|ensembl:ENSP00000503699|ensembl:ENSP00000503939|ensembl:ENSP00000504140|ensembl:ENSP00000504627|uniprotkb:Q5HYE9 intact:EBI-353620|uniprotkb:P20670|uniprotkb:B2R5F0|ensembl:ENSP00000358155|ensembl:ENSP00000475814 psi-mi:g3bp1_human(display_long)|uniprotkb:G3BP1(gene name)|psi-mi:G3BP1(display_short)|uniprotkb:G3BP(gene name synonym)|uniprotkb:ATP-dependent DNA helicase VIII(gene name synonym)|uniprotkb:GAP SH3 domain-binding protein 1(gene name synonym) psi-mi:h2a2a_human(display_long)|uniprotkb:H2AC18(gene name)|psi-mi:H2AC18(display_short)|uniprotkb:H2AC19(gene name)|psi-mi:H2AC19(display_short)|uniprotkb:H2A-clustered histone 18(gene name synonym)|uniprotkb:H2A-clustered histone 19(gene name synonym)|uniprotkb:H2AFO(gene name synonym)|uniprotkb:HIST2H2AA(gene name synonym)|uniprotkb:HIST2H2AA3(gene name synonym)|uniprotkb:HIST2H2AA4(gene name synonym)|uniprotkb:Histone H2A.2(gene name synonym)|uniprotkb:Histone H2A/o(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514311|imex:IM-12079-90 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005745.1|refseq:NP_938405.1|ensembl:ENSG00000145907(gene)|go:"GO:0003729"(mRNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0033677"(DNA/RNA helicase activity)|go:"GO:0034063"(stress granule assembly)|go:"GO:0043204"(perikaryon)|go:"GO:0045087"(innate immune response)|go:"GO:0051607"(defense response to virus)|go:"GO:0062029"(positive regulation of stress granule assembly)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR002075(Nuclear transport factor 2)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR018222|interpro:IPR032710|interpro:IPR034374|interpro:IPR034375|interpro:IPR035979|interpro:IPR039539|mint:Q13283|ensembl:ENST00000356245(transcript)|rcsb pdb:3Q90|rcsb pdb:4FCJ|rcsb pdb:4FCM|rcsb pdb:4IIA|rcsb pdb:5FW5|rcsb pdb:6TA7|ensembl:ENST00000394123(transcript)|ensembl:ENST00000522761(transcript)|ensembl:ENST00000676827(transcript)|ensembl:ENST00000676978(transcript)|ensembl:ENST00000677323(transcript)|ensembl:ENST00000678070(transcript)|ensembl:ENST00000678101(transcript)|ensembl:ENST00000678925(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|refseq:XP_006714812.1|refseq:XP_006714813.1|refseq:XP_016864411.1|refseq:XP_016864412.1 refseq:NP_001035807.1|refseq:NP_003507.1|ensembl:ENSG00000203812(gene)|ensembl:ENSG00000272196(gene)|ensembl:ENST00000369159(transcript)|ensembl:ENST00000607355(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006342"|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002119(Histone H2A)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|interpro:IPR032454|interpro:IPR032458|rcsb pdb:6SE6|rcsb pdb:6SEE|rcsb pdb:6SEF|rcsb pdb:6SEG|rcsb pdb:6Y5D|rcsb pdb:7JZV|reactome:R-HSA-110328|reactome:R-HSA-110329|reactome:R-HSA-110330|reactome:R-HSA-110331|reactome:R-HSA-1221632|reactome:R-HSA-171306|reactome:R-HSA-1912408|reactome:R-HSA-201722|reactome:R-HSA-212300|reactome:R-HSA-2299718|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559586|reactome:R-HSA-3214815|reactome:R-HSA-3214847|reactome:R-HSA-3214858|reactome:R-HSA-427359|reactome:R-HSA-427389|reactome:R-HSA-427413|reactome:R-HSA-5250924|reactome:R-HSA-5334118|reactome:R-HSA-5578749|reactome:R-HSA-5617472|reactome:R-HSA-5625886|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-5689901|reactome:R-HSA-606279|reactome:R-HSA-73728|reactome:R-HSA-73772|reactome:R-HSA-8936459|reactome:R-HSA-8939236|reactome:R-HSA-9018519|reactome:R-HSA-912446|reactome:R-HSA-9609690|reactome:R-HSA-9610379|reactome:R-HSA-9616222|reactome:R-HSA-9670095|reactome:R-HSA-9710421|reactome:R-HSA-977225|dip:DIP-33167N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/11/01 rogid:0ZRCHNVEmmtGEOASNwg3kIm2uys9606 rogid:PMuIm2XMN5q4wk+wYJ94mmnCe4w9606 intact-crc:8E216454F46800F3|rigid:gx7W2dWGqMoA6e4mZ3ejWOlMHeM false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q13283 uniprotkb:P37198 intact:EBI-1047359|intact:EBI-1384154|ensembl:ENSP00000348578|ensembl:ENSP00000377681|ensembl:ENSP00000430480|ensembl:ENSP00000502880|ensembl:ENSP00000503039|ensembl:ENSP00000503699|ensembl:ENSP00000503939|ensembl:ENSP00000504140|ensembl:ENSP00000504627|uniprotkb:Q5HYE9 intact:EBI-347978|intact:EBI-28983799|ensembl:ENSP00000305503|ensembl:ENSP00000407331|ensembl:ENSP00000471191|ensembl:ENSP00000473192|uniprotkb:Q6GTM2|uniprotkb:Q503A4|uniprotkb:Q96C43|uniprotkb:Q9NSL1|uniprotkb:B3KWU5 psi-mi:g3bp1_human(display_long)|uniprotkb:G3BP1(gene name)|psi-mi:G3BP1(display_short)|uniprotkb:G3BP(gene name synonym)|uniprotkb:ATP-dependent DNA helicase VIII(gene name synonym)|uniprotkb:GAP SH3 domain-binding protein 1(gene name synonym) psi-mi:nup62_human(display_long)|uniprotkb:NUP62(gene name)|psi-mi:NUP62(display_short)|uniprotkb:62 kDa nucleoporin(gene name synonym)|uniprotkb:Nucleoporin Nup62(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514311|imex:IM-12079-90 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005745.1|refseq:NP_938405.1|ensembl:ENSG00000145907(gene)|go:"GO:0003729"(mRNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0033677"(DNA/RNA helicase activity)|go:"GO:0034063"(stress granule assembly)|go:"GO:0043204"(perikaryon)|go:"GO:0045087"(innate immune response)|go:"GO:0051607"(defense response to virus)|go:"GO:0062029"(positive regulation of stress granule assembly)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR002075(Nuclear transport factor 2)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR018222|interpro:IPR032710|interpro:IPR034374|interpro:IPR034375|interpro:IPR035979|interpro:IPR039539|mint:Q13283|ensembl:ENST00000356245(transcript)|rcsb pdb:3Q90|rcsb pdb:4FCJ|rcsb pdb:4FCM|rcsb pdb:4IIA|rcsb pdb:5FW5|rcsb pdb:6TA7|ensembl:ENST00000394123(transcript)|ensembl:ENST00000522761(transcript)|ensembl:ENST00000676827(transcript)|ensembl:ENST00000676978(transcript)|ensembl:ENST00000677323(transcript)|ensembl:ENST00000678070(transcript)|ensembl:ENST00000678101(transcript)|ensembl:ENST00000678925(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|refseq:XP_006714812.1|refseq:XP_006714813.1|refseq:XP_016864411.1|refseq:XP_016864412.1 refseq:NP_714941.1|ensembl:ENSG00000213024(gene)|ensembl:ENST00000352066(transcript)|ensembl:ENST00000422090(transcript)|ensembl:ENST00000596217(transcript)|ensembl:ENST00000597029(transcript)|go:"GO:0000922"(spindle pole)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005642"(annulate lamellae)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0006405"(RNA export from nucleus)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007100"(mitotic centrosome separation)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007569"(cell aging)|go:"GO:0008219"(cell death)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0003682"(chromatin binding)|go:"GO:0017056"(structural constituent of nuclear pore)|go:"GO:0019894"(kinesin binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042306"(regulation of protein import into nucleus)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043069"(negative regulation of programmed cell death)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0044613"(nuclear pore central transport channel)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046578"(regulation of Ras protein signal transduction)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0046601"(positive regulation of centriole replication)|go:"GO:0051028"(mRNA transport)|go:"GO:0051425"(PTB domain binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060236"(regulation of mitotic spindle organization)|go:"GO:0072686"(mitotic spindle)|reactome:R-HSA-3371453|reactome:R-HSA-4085377|reactome:R-HSA-4551638|reactome:R-HSA-4570464|reactome:R-HSA-4615885|reactome:R-HSA-5578749|reactome:R-HSA-5619107|reactome:R-HSA-6784531|reactome:R-HSA-9609690|reactome:R-HSA-9610379|reactome:R-HSA-9615933|go:"GO:0090543"(Flemming body)|go:"GO:0098534"(centriole assembly)|go:"GO:1903438"(positive regulation of mitotic cytokinetic process)|go:"GO:1904781"(positive regulation of protein localization to centrosome)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR007758(Nucleoporin, Nsp1-like, C-terminal)|interpro:IPR026010|interpro:IPR033072|mint:P37198|rcsb pdb:2H4D|rcsb pdb:5IJN|rcsb pdb:5IJO|reactome:R-HSA-1169408|reactome:R-HSA-159227|reactome:R-HSA-159230|reactome:R-HSA-159231|reactome:R-HSA-159236|reactome:R-HSA-165054|reactome:R-HSA-168271|reactome:R-HSA-168276|reactome:R-HSA-168325|reactome:R-HSA-168333|reactome:R-HSA-170822|reactome:R-HSA-180746|reactome:R-HSA-180910|reactome:R-HSA-191859|reactome:R-HSA-3108214|reactome:R-HSA-3232142|reactome:R-HSA-3301854|refseq:NP_714940.1|refseq:NP_001180286.1|refseq:NP_036478.2|refseq:NP_057637.2|ensembl:ENSP00000305503|ensembl:ENSP00000407331|ensembl:ENSP00000471191|ensembl:ENSP00000473192|dip:DIP-29749N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/11/01 rogid:0ZRCHNVEmmtGEOASNwg3kIm2uys9606 rogid:v7mvKvTtVEnLMwcpUZIcdAzge009606 intact-crc:8E216454F46800F3|rigid:gx7W2dWGqMoA6e4mZ3ejWOlMHeM false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q13283 uniprotkb:Q96RL1 intact:EBI-1047359|intact:EBI-1384154|ensembl:ENSP00000348578|ensembl:ENSP00000377681|ensembl:ENSP00000430480|ensembl:ENSP00000502880|ensembl:ENSP00000503039|ensembl:ENSP00000503699|ensembl:ENSP00000503939|ensembl:ENSP00000504140|ensembl:ENSP00000504627|uniprotkb:Q5HYE9 intact:EBI-725300|intact:EBI-1263554|uniprotkb:Q5XKQ1|uniprotkb:Q7Z3W7|uniprotkb:Q8N5B9|uniprotkb:Q9BZR1|uniprotkb:Q9BZR5|uniprotkb:Q9UHX7|uniprotkb:A8MSA1|uniprotkb:B3KMZ1|uniprotkb:B4E3N2|ensembl:ENSP00000366434|ensembl:ENSP00000421926 psi-mi:g3bp1_human(display_long)|uniprotkb:G3BP1(gene name)|psi-mi:G3BP1(display_short)|uniprotkb:G3BP(gene name synonym)|uniprotkb:ATP-dependent DNA helicase VIII(gene name synonym)|uniprotkb:GAP SH3 domain-binding protein 1(gene name synonym) psi-mi:uimc1_human(display_long)|uniprotkb:Retinoid X receptor-interacting protein 110(gene name synonym)|uniprotkb:Receptor-associated protein 80(gene name synonym)|uniprotkb:Ubiquitin interaction motif-containing protein 1(gene name synonym)|uniprotkb:UIMC1(gene name)|psi-mi:UIMC1(display_short)|uniprotkb:RAP80(gene name synonym)|uniprotkb:RXRIP110(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514311|imex:IM-12079-90 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005745.1|refseq:NP_938405.1|ensembl:ENSG00000145907(gene)|go:"GO:0003729"(mRNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0033677"(DNA/RNA helicase activity)|go:"GO:0034063"(stress granule assembly)|go:"GO:0043204"(perikaryon)|go:"GO:0045087"(innate immune response)|go:"GO:0051607"(defense response to virus)|go:"GO:0062029"(positive regulation of stress granule assembly)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR002075(Nuclear transport factor 2)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR018222|interpro:IPR032710|interpro:IPR034374|interpro:IPR034375|interpro:IPR035979|interpro:IPR039539|mint:Q13283|ensembl:ENST00000356245(transcript)|rcsb pdb:3Q90|rcsb pdb:4FCJ|rcsb pdb:4FCM|rcsb pdb:4IIA|rcsb pdb:5FW5|rcsb pdb:6TA7|ensembl:ENST00000394123(transcript)|ensembl:ENST00000522761(transcript)|ensembl:ENST00000676827(transcript)|ensembl:ENST00000676978(transcript)|ensembl:ENST00000677323(transcript)|ensembl:ENST00000678070(transcript)|ensembl:ENST00000678101(transcript)|ensembl:ENST00000678925(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|refseq:XP_006714812.1|refseq:XP_006714813.1|refseq:XP_016864411.1|refseq:XP_016864412.1 refseq:NP_001186226.1|refseq:NP_001186227.1|refseq:NP_057374.3|refseq:NP_001304890.1|ensembl:ENSG00000087206(gene)|ensembl:ENST00000377227(transcript)|ensembl:ENST00000511320(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006302"(double-strand break repair)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016604"(nuclear body)|go:"GO:0042393"(histone binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0070531"(BRCA1-A complex)|go:"GO:0070537"(histone H2A K63-linked deubiquitination)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR006642(Zinc finger, Rad18-type putative)|interpro:IPR038868|interpro:IPR040714|mint:Q96RL1|rcsb pdb:2MKF|rcsb pdb:2MKG|rcsb pdb:2N9E|rcsb pdb:2RR9|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473|refseq:XP_005265987.1|refseq:XP_005265993.1|refseq:XP_006714934.1|refseq:XP_016865063.1|refseq:XP_016865067.1|refseq:XP_016865068.1|dip:DIP-29936N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/11/01 rogid:0ZRCHNVEmmtGEOASNwg3kIm2uys9606 rogid:j5ho+aD4tkX7bXXlROdiprUX1Mc9606 intact-crc:8E216454F46800F3|rigid:gx7W2dWGqMoA6e4mZ3ejWOlMHeM false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q13283 uniprotkb:O14929 intact:EBI-1047359|intact:EBI-1384154|ensembl:ENSP00000348578|ensembl:ENSP00000377681|ensembl:ENSP00000430480|ensembl:ENSP00000502880|ensembl:ENSP00000503039|ensembl:ENSP00000503699|ensembl:ENSP00000503939|ensembl:ENSP00000504140|ensembl:ENSP00000504627|uniprotkb:Q5HYE9 intact:EBI-2339359|uniprotkb:Q53SU4|uniprotkb:Q53QF0|uniprotkb:Q49A44|uniprotkb:Q6P594|uniprotkb:Q8WWB9|ensembl:ENSP00000264108 psi-mi:g3bp1_human(display_long)|uniprotkb:G3BP1(gene name)|psi-mi:G3BP1(display_short)|uniprotkb:G3BP(gene name synonym)|uniprotkb:ATP-dependent DNA helicase VIII(gene name synonym)|uniprotkb:GAP SH3 domain-binding protein 1(gene name synonym) psi-mi:hat1_human(display_long)|uniprotkb:HAT1(gene name)|psi-mi:HAT1(display_short)|uniprotkb:KAT1(gene name synonym)|uniprotkb:Histone acetyltransferase 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514311|imex:IM-12079-90 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_005745.1|refseq:NP_938405.1|ensembl:ENSG00000145907(gene)|go:"GO:0003729"(mRNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0033677"(DNA/RNA helicase activity)|go:"GO:0034063"(stress granule assembly)|go:"GO:0043204"(perikaryon)|go:"GO:0045087"(innate immune response)|go:"GO:0051607"(defense response to virus)|go:"GO:0062029"(positive regulation of stress granule assembly)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR002075(Nuclear transport factor 2)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR018222|interpro:IPR032710|interpro:IPR034374|interpro:IPR034375|interpro:IPR035979|interpro:IPR039539|mint:Q13283|ensembl:ENST00000356245(transcript)|rcsb pdb:3Q90|rcsb pdb:4FCJ|rcsb pdb:4FCM|rcsb pdb:4IIA|rcsb pdb:5FW5|rcsb pdb:6TA7|ensembl:ENST00000394123(transcript)|ensembl:ENST00000522761(transcript)|ensembl:ENST00000676827(transcript)|ensembl:ENST00000676978(transcript)|ensembl:ENST00000677323(transcript)|ensembl:ENST00000678070(transcript)|ensembl:ENST00000678101(transcript)|ensembl:ENST00000678925(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|refseq:XP_006714812.1|refseq:XP_006714813.1|refseq:XP_016864411.1|refseq:XP_016864412.1 refseq:NP_003633.1|dip:DIP-52811N|ensembl:ENSG00000128708(gene)|ensembl:ENST00000264108(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0004402"(histone acetyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006323"(DNA packaging)|go:"GO:0006335"(DNA replication-dependent chromatin assembly)|go:"GO:0006336"(DNA replication-independent chromatin assembly)|go:"GO:0006348"|go:"GO:0006475"(internal protein amino acid acetylation)|go:"GO:0007584"(response to nutrient)|go:"GO:0010485"(H4 histone acetyltransferase activity)|go:"GO:0016363"(nuclear matrix)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042393"(histone binding)|go:"GO:0043967"(histone H4 acetylation)|interpro:IPR013523(Histone acetyltransferase HAT1, C-terminal)|interpro:IPR016181(Acyl-CoA N-acyltransferase)|interpro:IPR017380(Histone acetyltransferase type B, catalytic subunit)|interpro:IPR019467|interpro:IPR037113|mint:O14929|rcsb pdb:2P0W|rcsb pdb:6VO5|reactome:R-HSA-3214847 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/11/01 rogid:0ZRCHNVEmmtGEOASNwg3kIm2uys9606 rogid:80KgRaid3NeRfAUdTHMQ/r0VuGo9606 intact-crc:8E216454F46800F3|rigid:gx7W2dWGqMoA6e4mZ3ejWOlMHeM false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9NWV8 uniprotkb:P46060 intact:EBI-745725|uniprotkb:Q6FIA0|uniprotkb:Q9P018|uniprotkb:A8MQT0|uniprotkb:B4DRY9|uniprotkb:B4DVR1|ensembl:ENSP00000352408|ensembl:ENSP00000470920|ensembl:ENSP00000471605 intact:EBI-396091|uniprotkb:Q96JJ2|ensembl:ENSP00000401470|ensembl:ENSP00000348577|ensembl:ENSP00000385866 psi-mi:baba1_human(display_long)|uniprotkb:BABAM1(gene name)|psi-mi:BABAM1(display_short)|uniprotkb:HSPC142(orf name)|uniprotkb:C19orf62(gene name synonym)|uniprotkb:NBA1(gene name synonym)|uniprotkb:Mediator of RAP80 interactions and targeting subunit of 40 kDa(gene name synonym)|uniprotkb:New component of the BRCA1-A complex(gene name synonym)|uniprotkb:MERIT40(gene name synonym) psi-mi:ragp1_human(display_long)|uniprotkb:RANGAP1(gene name)|psi-mi:RANGAP1(display_short)|uniprotkb:KIAA1835(gene name synonym)|uniprotkb:SD(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514464|imex:IM-12079-91 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001028721.1|refseq:NP_054892.2|ensembl:ENSG00000105393(gene)|ensembl:ENST00000359435(transcript)|ensembl:ENST00000598188(transcript)|ensembl:ENST00000601043(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006325"(chromatin organization)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016604"(nuclear body)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0051301"(cell division)|go:"GO:0070531"(BRCA1-A complex)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0070552"(BRISC complex)|interpro:IPR026126|interpro:IPR036465|mint:Q9NWV8|rcsb pdb:6H3C|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473|refseq:NP_001275685.1|refseq:NP_001275686.1 refseq:NP_002874.1|ensembl:ENST00000356244(transcript)|ensembl:ENST00000405486(transcript)|ensembl:ENST00000455915(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0003723"(RNA binding)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0016235"(aggresome)|go:"GO:0030425"(dendrite)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|refseq:XP_011528596.1|refseq:XP_011528597.1|refseq:NP_001304859.1|go:"GO:0031965"(nuclear membrane)|interpro:IPR009109(Ran-GTPase activating protein 1, C-terminal)|interpro:IPR032675|interpro:IPR036720|mint:P46060|rcsb pdb:1Z5S|rcsb pdb:2GRN|rcsb pdb:2GRO|rcsb pdb:2GRP|rcsb pdb:2GRQ|rcsb pdb:2GRR|rcsb pdb:2IO2|rcsb pdb:2IO3|rcsb pdb:2IY0|rcsb pdb:3UIN|rcsb pdb:3UIO|rcsb pdb:3UIP|rcsb pdb:5D2M|reactome:R-HSA-141444|reactome:R-HSA-165054|reactome:R-HSA-2467813|interpro:IPR001611(Leucine-rich repeat)|reactome:R-HSA-2500257|reactome:R-HSA-3108232|go:"GO:0044614"(nuclear pore cytoplasmic filaments)|go:"GO:0045296"(cadherin binding)|go:"GO:0046826"(negative regulation of protein export from nucleus)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048678"(response to axon injury)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1904117"(cellular response to vasopressin)|go:"GO:1990723"(cytoplasmic periphery of the nuclear pore complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|ensembl:ENSG00000100401(gene)|refseq:XP_006724352.1|reactome:R-HSA-4615885|refseq:NP_001265580.1|reactome:R-HSA-68877|reactome:R-HSA-9615933|reactome:R-HSA-9648025|reactome:R-HSA-5663220|refseq:XP_016884382.1|refseq:XP_016884383.1|refseq:XP_016884384.1|refseq:XP_016884385.1|refseq:XP_016884386.1|dip:DIP-29079N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:o71OvjzuL/7w4247ap7fm6i3pXU9606 rogid:pUpd+7p5CeAKaRGLo/bXTeiwjiM9606 intact-crc:2F9E49C582BB9C1C|rigid:trNYDYqpT7OPgee2YiBJgfHUhqw false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9NWV8 uniprotkb:P53350 intact:EBI-745725|uniprotkb:Q6FIA0|uniprotkb:Q9P018|uniprotkb:A8MQT0|uniprotkb:B4DRY9|uniprotkb:B4DVR1|ensembl:ENSP00000352408|ensembl:ENSP00000470920|ensembl:ENSP00000471605 intact:EBI-476768|uniprotkb:Q15153|uniprotkb:Q99746|ensembl:ENSP00000300093 psi-mi:baba1_human(display_long)|uniprotkb:BABAM1(gene name)|psi-mi:BABAM1(display_short)|uniprotkb:HSPC142(orf name)|uniprotkb:C19orf62(gene name synonym)|uniprotkb:NBA1(gene name synonym)|uniprotkb:Mediator of RAP80 interactions and targeting subunit of 40 kDa(gene name synonym)|uniprotkb:New component of the BRCA1-A complex(gene name synonym)|uniprotkb:MERIT40(gene name synonym) psi-mi:plk1_human(display_long)|uniprotkb:Polo-like kinase 1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 13(gene name synonym)|uniprotkb:PLK1(gene name)|psi-mi:PLK1(display_short)|uniprotkb:PLK(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514464|imex:IM-12079-91 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001028721.1|refseq:NP_054892.2|ensembl:ENSG00000105393(gene)|ensembl:ENST00000359435(transcript)|ensembl:ENST00000598188(transcript)|ensembl:ENST00000601043(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006325"(chromatin organization)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016604"(nuclear body)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0051301"(cell division)|go:"GO:0070531"(BRCA1-A complex)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0070552"(BRISC complex)|interpro:IPR026126|interpro:IPR036465|mint:Q9NWV8|rcsb pdb:6H3C|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473|refseq:NP_001275685.1|refseq:NP_001275686.1 refseq:NP_005021.2|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0034451"(centriolar satellite)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0045143"(homologous chromosome segregation)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045862"(positive regulation of proteolysis)|go:"GO:0051081"(nuclear membrane disassembly)|go:"GO:0051233"(spindle midzone)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070194"(synaptonemal complex disassembly)|go:"GO:0071168"(protein localization to chromatin)|go:"GO:0090435"(protein localization to nuclear envelope)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901673"(regulation of mitotic spindle assembly)|go:"GO:1901990"(regulation of mitotic cell cycle phase transition)|ensembl:ENSG00000166851(gene)|ensembl:ENST00000300093(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000776"(kinetochore)|go:"GO:0000785"(chromatin)|go:"GO:0000795"(synaptonemal complex)|go:"GO:0000922"(spindle pole)|go:"GO:0000940"(outer kinetochore)|go:"GO:0001578"(microtubule bundle formation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0007076"(mitotic chromosome condensation)|go:"GO:0007077"(mitotic nuclear membrane disassembly)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0005524"(ATP binding)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0008017"(microtubule binding)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0010997"(anaphase-promoting complex binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016321"(female meiosis chromosome segregation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030071"(regulation of mitotic metaphase/anaphase transition)|go:"GO:0030496"(midbody)|go:"GO:0031648"(protein destabilization)|rcsb pdb:4DFW|rcsb pdb:4E67|rcsb pdb:4E9C|rcsb pdb:4E9D|rcsb pdb:4H5X|rcsb pdb:4H71|rcsb pdb:4HAB|rcsb pdb:4HCO|rcsb pdb:4HY2|rcsb pdb:4J52|rcsb pdb:4J53|rcsb pdb:4LKL|rcsb pdb:4LKM|rcsb pdb:4O56|rcsb pdb:4O6W|rcsb pdb:4O9W|rcsb pdb:4RCP|rcsb pdb:4WHH|rcsb pdb:4WHK|rcsb pdb:4WHL|rcsb pdb:4X9R|rcsb pdb:4X9V|rcsb pdb:4X9W|rcsb pdb:5J19|rcsb pdb:5NEI|rcsb pdb:5NFU|rcsb pdb:5NJE|rcsb pdb:5NMM|rcsb pdb:5NN1|rcsb pdb:5NN2|rcsb pdb:5TA6|rcsb pdb:5TA8|rcsb pdb:6AX4|rcsb pdb:6GY2|reactome:R-HSA-141444|reactome:R-HSA-156711|reactome:R-HSA-162658|reactome:R-HSA-174178|reactome:R-HSA-176412|reactome:R-HSA-176417|reactome:R-HSA-2299718|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-2565942|reactome:R-HSA-2980767|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-68881|reactome:R-HSA-68884|reactome:R-HSA-69273|reactome:R-HSA-8852276|reactome:R-HSA-8854518|reactome:R-HSA-9648025|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|go:"GO:1904776"(regulation of protein localization to cell cortex)|go:"GO:1905784"(regulation of anaphase-promoting complex-dependent catabolic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000959(POLO box duplicated region)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033695|interpro:IPR033701|interpro:IPR033702|interpro:IPR036947|mint:P53350|rcsb pdb:1Q4K|rcsb pdb:1Q4O|rcsb pdb:1UMW|rcsb pdb:2OGQ|rcsb pdb:2OJX|rcsb pdb:2OU7|rcsb pdb:2OWB|rcsb pdb:2RKU|rcsb pdb:2V5Q|rcsb pdb:2YAC|rcsb pdb:3BZI|rcsb pdb:3C5L|rcsb pdb:3FC2|rcsb pdb:3FVH|rcsb pdb:3HIH|rcsb pdb:3HIK|rcsb pdb:3KB7|rcsb pdb:3P2W|rcsb pdb:3P2Z|rcsb pdb:3P34|rcsb pdb:3P35|rcsb pdb:3P36|rcsb pdb:3P37|rcsb pdb:3Q1I|rcsb pdb:3RQ7|rcsb pdb:3THB|rcsb pdb:4A4L|rcsb pdb:4A4O|dip:DIP-29696N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:o71OvjzuL/7w4247ap7fm6i3pXU9606 rogid:fBOK366hV6mDprx9IWhz43gPcJE9606 intact-crc:2F9E49C582BB9C1C|rigid:trNYDYqpT7OPgee2YiBJgfHUhqw false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9NWV8 uniprotkb:Q9Y2L1 intact:EBI-745725|uniprotkb:Q6FIA0|uniprotkb:Q9P018|uniprotkb:A8MQT0|uniprotkb:B4DRY9|uniprotkb:B4DVR1|ensembl:ENSP00000352408|ensembl:ENSP00000470920|ensembl:ENSP00000471605 intact:EBI-373539|uniprotkb:A6NI21|uniprotkb:Q5W0P7|uniprotkb:Q5W0P8|uniprotkb:Q658Z7|uniprotkb:Q7Z481|uniprotkb:Q8WWI2|uniprotkb:Q9UG36|uniprotkb:B2RBL2|ensembl:ENSP00000366997 psi-mi:baba1_human(display_long)|uniprotkb:BABAM1(gene name)|psi-mi:BABAM1(display_short)|uniprotkb:HSPC142(orf name)|uniprotkb:C19orf62(gene name synonym)|uniprotkb:NBA1(gene name synonym)|uniprotkb:Mediator of RAP80 interactions and targeting subunit of 40 kDa(gene name synonym)|uniprotkb:New component of the BRCA1-A complex(gene name synonym)|uniprotkb:MERIT40(gene name synonym) psi-mi:rrp44_human(display_long)|uniprotkb:DIS3(gene name)|psi-mi:DIS3(display_short)|uniprotkb:Ribosomal RNA-processing protein 44(gene name synonym)|uniprotkb:Protein DIS3 homolog(gene name synonym)|uniprotkb:KIAA1008(gene name synonym)|uniprotkb:RRP44(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514464|imex:IM-12079-91 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001028721.1|refseq:NP_054892.2|ensembl:ENSG00000105393(gene)|ensembl:ENST00000359435(transcript)|ensembl:ENST00000598188(transcript)|ensembl:ENST00000601043(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006325"(chromatin organization)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016604"(nuclear body)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0051301"(cell division)|go:"GO:0070531"(BRCA1-A complex)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0070552"(BRISC complex)|interpro:IPR026126|interpro:IPR036465|mint:Q9NWV8|rcsb pdb:6H3C|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473|refseq:NP_001275685.1|refseq:NP_001275686.1 refseq:NP_001121698.1|refseq:NP_055768.3|ensembl:ENSG00000083520(gene)|ensembl:ENST00000377767(transcript)|go:"GO:0000175"(3'-5'-exoribonuclease activity)|go:"GO:0000176"("nuclear exosome (RNase complex)")|go:"GO:0000177"("cytoplasmic exosome (RNase complex)")|go:"GO:0000178"("exosome (RNase complex)")|go:"GO:0003723"(RNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006364"(rRNA processing)|go:"GO:0016020"(membrane)|go:"GO:0016075"(rRNA catabolic process)|go:"GO:0043928"(exonucleolytic catabolism of deadenylated mRNA)|go:"GO:0071034"(CUT catabolic process)|interpro:IPR001900(Ribonuclease II and R)|interpro:IPR002716(PilT protein, N-terminal)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR022966|interpro:IPR029060|interpro:IPR033770|interpro:IPR033771|interpro:IPR041505|mint:Q9Y2L1|rcsb pdb:6D6Q|rcsb pdb:6D6R|rcsb pdb:6H25|reactome:R-HSA-380994|reactome:R-HSA-429958|reactome:R-HSA-450385|reactome:R-HSA-450513|reactome:R-HSA-450604|reactome:R-HSA-6791226 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:o71OvjzuL/7w4247ap7fm6i3pXU9606 rogid:cHOcZh1JkvywNK4Tq2DUvPMm6kc9606 intact-crc:2F9E49C582BB9C1C|rigid:trNYDYqpT7OPgee2YiBJgfHUhqw false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9NWV8 uniprotkb:O76031 intact:EBI-745725|uniprotkb:Q6FIA0|uniprotkb:Q9P018|uniprotkb:A8MQT0|uniprotkb:B4DRY9|uniprotkb:B4DVR1|ensembl:ENSP00000352408|ensembl:ENSP00000470920|ensembl:ENSP00000471605 intact:EBI-1052667|uniprotkb:A1L428|uniprotkb:A8K8F1|uniprotkb:Q9H4D9|uniprotkb:B9EGI8|ensembl:ENSP00000300107 psi-mi:baba1_human(display_long)|uniprotkb:BABAM1(gene name)|psi-mi:BABAM1(display_short)|uniprotkb:HSPC142(orf name)|uniprotkb:C19orf62(gene name synonym)|uniprotkb:NBA1(gene name synonym)|uniprotkb:Mediator of RAP80 interactions and targeting subunit of 40 kDa(gene name synonym)|uniprotkb:New component of the BRCA1-A complex(gene name synonym)|uniprotkb:MERIT40(gene name synonym) psi-mi:clpx_human(display_long)|uniprotkb:CLPX(gene name)|psi-mi:CLPX(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514464|imex:IM-12079-91 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001028721.1|refseq:NP_054892.2|ensembl:ENSG00000105393(gene)|ensembl:ENST00000359435(transcript)|ensembl:ENST00000598188(transcript)|ensembl:ENST00000601043(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006325"(chromatin organization)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016604"(nuclear body)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0051301"(cell division)|go:"GO:0070531"(BRCA1-A complex)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0070552"(BRISC complex)|interpro:IPR026126|interpro:IPR036465|mint:Q9NWV8|rcsb pdb:6H3C|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473|refseq:NP_001275685.1|refseq:NP_001275686.1 refseq:NP_006651.2|ensembl:ENSG00000166855(gene)|ensembl:ENST00000300107(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006508"(proteolysis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009368"(endopeptidase Clp complex)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0030163"(protein catabolic process)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR004487(ClpX, ATPase regulatory subunit)|interpro:IPR010603(Zinc finger, C4-type)|interpro:IPR019489|interpro:IPR027417|go:"GO:0009841"(mitochondrial endopeptidase Clp complex)|mint:O76031|dip:DIP-50293N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:o71OvjzuL/7w4247ap7fm6i3pXU9606 rogid:+SOis7raPEZqqeel6Y6dOWJcLj49606 intact-crc:2F9E49C582BB9C1C|rigid:trNYDYqpT7OPgee2YiBJgfHUhqw false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9NWV8 uniprotkb:P30044 intact:EBI-745725|uniprotkb:Q6FIA0|uniprotkb:Q9P018|uniprotkb:A8MQT0|uniprotkb:B4DRY9|uniprotkb:B4DVR1|ensembl:ENSP00000352408|ensembl:ENSP00000470920|ensembl:ENSP00000471605 intact:EBI-722161|uniprotkb:Q14CK0|uniprotkb:Q6IAF2|uniprotkb:Q9UBU5|uniprotkb:Q9UJU4|uniprotkb:Q9UKX4|uniprotkb:A6NG06|uniprotkb:B7ZLJ4|uniprotkb:A6NC19|uniprotkb:B7ZVW3|ensembl:ENSP00000265462 psi-mi:baba1_human(display_long)|uniprotkb:BABAM1(gene name)|psi-mi:BABAM1(display_short)|uniprotkb:HSPC142(orf name)|uniprotkb:C19orf62(gene name synonym)|uniprotkb:NBA1(gene name synonym)|uniprotkb:Mediator of RAP80 interactions and targeting subunit of 40 kDa(gene name synonym)|uniprotkb:New component of the BRCA1-A complex(gene name synonym)|uniprotkb:MERIT40(gene name synonym) psi-mi:prdx5_human(display_long)|uniprotkb:Peroxiredoxin V(gene name synonym)|uniprotkb:Peroxisomal antioxidant enzyme(gene name synonym)|uniprotkb:PLP(gene name synonym)|uniprotkb:Thioredoxin peroxidase PMP20(gene name synonym)|uniprotkb:Antioxidant enzyme B166(gene name synonym)|uniprotkb:TPx type VI(gene name synonym)|uniprotkb:Liver tissue 2D-page spot 71B(gene name synonym)|uniprotkb:Alu corepressor 1(gene name synonym)|uniprotkb:PRDX5(gene name)|psi-mi:PRDX5(display_short)|uniprotkb:ACR1(gene name synonym)|uniprotkb:Thioredoxin-dependent peroxiredoxin 5(gene name synonym)|uniprotkb:SBBI10(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514464|imex:IM-12079-91 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001028721.1|refseq:NP_054892.2|ensembl:ENSG00000105393(gene)|ensembl:ENST00000359435(transcript)|ensembl:ENST00000598188(transcript)|ensembl:ENST00000601043(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006325"(chromatin organization)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016604"(nuclear body)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0051301"(cell division)|go:"GO:0070531"(BRCA1-A complex)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0070552"(BRISC complex)|interpro:IPR026126|interpro:IPR036465|mint:Q9NWV8|rcsb pdb:6H3C|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473|refseq:NP_001275685.1|refseq:NP_001275686.1 refseq:NP_036226.1|refseq:NP_857634.1|refseq:NP_857635.1|ensembl:ENSG00000126432(gene)|ensembl:ENST00000265462(transcript)|go:"GO:0001016"(RNA polymerase III transcription regulatory region sequence-specific DNA binding)|go:"GO:0004601"(peroxidase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005777"(peroxisome)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006954"(inflammatory response)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008379"(thioredoxin peroxidase activity)|go:"GO:0016209"(antioxidant activity)|go:"GO:0016480"(negative regulation of transcription by RNA polymerase III)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0042744"(hydrogen peroxide catabolic process)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051354"(negative regulation of oxidoreductase activity)|go:"GO:0051920"(peroxiredoxin activity)|go:"GO:0060785"(regulation of apoptosis involved in tissue homeostasis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070995"(NADPH oxidation)|go:"GO:0072541"(peroxynitrite reductase activity)|go:"GO:2001057"(reactive nitrogen species metabolic process)|interpro:IPR013740(Redoxin)|interpro:IPR013766(Thioredoxin domain)|interpro:IPR036249|interpro:IPR037944|mint:P30044|rcsb pdb:1H4O|rcsb pdb:1HD2|rcsb pdb:1OC3|rcsb pdb:1URM|rcsb pdb:2VL2|rcsb pdb:2VL3|rcsb pdb:2VL9|rcsb pdb:3MNG|rcsb pdb:4K7I|rcsb pdb:4K7N|rcsb pdb:4K7O|rcsb pdb:4MMM|reactome:R-HSA-3299685|reactome:R-HSA-5628897 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:o71OvjzuL/7w4247ap7fm6i3pXU9606 rogid:Z1fs04RUXWI7z+s7Y+hzGige4mU9606 intact-crc:2F9E49C582BB9C1C|rigid:trNYDYqpT7OPgee2YiBJgfHUhqw false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9NWV8 uniprotkb:Q15018 intact:EBI-745725|uniprotkb:Q6FIA0|uniprotkb:Q9P018|uniprotkb:A8MQT0|uniprotkb:B4DRY9|uniprotkb:B4DVR1|ensembl:ENSP00000352408|ensembl:ENSP00000470920|ensembl:ENSP00000471605 intact:EBI-1056583|uniprotkb:Q96H11|uniprotkb:B4DKR2|intact:EBI-28981592|ensembl:ENSP00000298492 psi-mi:baba1_human(display_long)|uniprotkb:BABAM1(gene name)|psi-mi:BABAM1(display_short)|uniprotkb:HSPC142(orf name)|uniprotkb:C19orf62(gene name synonym)|uniprotkb:NBA1(gene name synonym)|uniprotkb:Mediator of RAP80 interactions and targeting subunit of 40 kDa(gene name synonym)|uniprotkb:New component of the BRCA1-A complex(gene name synonym)|uniprotkb:MERIT40(gene name synonym) psi-mi:abrx2_human(display_long)|uniprotkb:ABRAXAS2(gene name)|psi-mi:ABRAXAS2(display_short)|uniprotkb:ABRO1(gene name synonym)|uniprotkb:Abraxas brother protein 1(gene name synonym)|uniprotkb:FAM175B(gene name synonym)|uniprotkb:KIAA0157(gene name synonym)|uniprotkb:Protein FAM175B(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514464|imex:IM-12079-91 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001028721.1|refseq:NP_054892.2|ensembl:ENSG00000105393(gene)|ensembl:ENST00000359435(transcript)|ensembl:ENST00000598188(transcript)|ensembl:ENST00000601043(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006325"(chromatin organization)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016604"(nuclear body)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0051301"(cell division)|go:"GO:0070531"(BRCA1-A complex)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0070552"(BRISC complex)|interpro:IPR026126|interpro:IPR036465|mint:Q9NWV8|rcsb pdb:6H3C|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473|refseq:NP_001275685.1|refseq:NP_001275686.1 ensembl:ENSP00000298492|refseq:NP_115558.3|ensembl:ENSG00000165660(gene)|ensembl:ENST00000298492(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000922"(spindle pole)|go:"GO:0002931"(response to ischemia)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0007059"(chromosome segregation)|go:"GO:0008017"(microtubule binding)|go:"GO:0008608"(attachment of spindle microtubules to kinetochore)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0051301"(cell division)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0070552"(BRISC complex)|go:"GO:0090307"(mitotic spindle assembly)|interpro:IPR023238|interpro:IPR023240|interpro:IPR037518|mint:Q15018|rcsb pdb:6H3C|rcsb pdb:6R8F|reactome:R-HSA-5689901 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:o71OvjzuL/7w4247ap7fm6i3pXU9606 rogid:fYZdQpH09qcBBUV1IKV2wsRk4m89606 intact-crc:2F9E49C582BB9C1C|rigid:trNYDYqpT7OPgee2YiBJgfHUhqw false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9NWV8 uniprotkb:Q96RL1 intact:EBI-745725|uniprotkb:Q6FIA0|uniprotkb:Q9P018|uniprotkb:A8MQT0|uniprotkb:B4DRY9|uniprotkb:B4DVR1|ensembl:ENSP00000352408|ensembl:ENSP00000470920|ensembl:ENSP00000471605 intact:EBI-725300|intact:EBI-1263554|uniprotkb:Q5XKQ1|uniprotkb:Q7Z3W7|uniprotkb:Q8N5B9|uniprotkb:Q9BZR1|uniprotkb:Q9BZR5|uniprotkb:Q9UHX7|uniprotkb:A8MSA1|uniprotkb:B3KMZ1|uniprotkb:B4E3N2|ensembl:ENSP00000366434|ensembl:ENSP00000421926 psi-mi:baba1_human(display_long)|uniprotkb:BABAM1(gene name)|psi-mi:BABAM1(display_short)|uniprotkb:HSPC142(orf name)|uniprotkb:C19orf62(gene name synonym)|uniprotkb:NBA1(gene name synonym)|uniprotkb:Mediator of RAP80 interactions and targeting subunit of 40 kDa(gene name synonym)|uniprotkb:New component of the BRCA1-A complex(gene name synonym)|uniprotkb:MERIT40(gene name synonym) psi-mi:uimc1_human(display_long)|uniprotkb:Retinoid X receptor-interacting protein 110(gene name synonym)|uniprotkb:Receptor-associated protein 80(gene name synonym)|uniprotkb:Ubiquitin interaction motif-containing protein 1(gene name synonym)|uniprotkb:UIMC1(gene name)|psi-mi:UIMC1(display_short)|uniprotkb:RAP80(gene name synonym)|uniprotkb:RXRIP110(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514464|imex:IM-12079-91 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001028721.1|refseq:NP_054892.2|ensembl:ENSG00000105393(gene)|ensembl:ENST00000359435(transcript)|ensembl:ENST00000598188(transcript)|ensembl:ENST00000601043(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006325"(chromatin organization)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016604"(nuclear body)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0051301"(cell division)|go:"GO:0070531"(BRCA1-A complex)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0070552"(BRISC complex)|interpro:IPR026126|interpro:IPR036465|mint:Q9NWV8|rcsb pdb:6H3C|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473|refseq:NP_001275685.1|refseq:NP_001275686.1 refseq:NP_001186226.1|refseq:NP_001186227.1|refseq:NP_057374.3|refseq:NP_001304890.1|ensembl:ENSG00000087206(gene)|ensembl:ENST00000377227(transcript)|ensembl:ENST00000511320(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006302"(double-strand break repair)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016604"(nuclear body)|go:"GO:0042393"(histone binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0070531"(BRCA1-A complex)|go:"GO:0070537"(histone H2A K63-linked deubiquitination)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR006642(Zinc finger, Rad18-type putative)|interpro:IPR038868|interpro:IPR040714|mint:Q96RL1|rcsb pdb:2MKF|rcsb pdb:2MKG|rcsb pdb:2N9E|rcsb pdb:2RR9|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473|refseq:XP_005265987.1|refseq:XP_005265993.1|refseq:XP_006714934.1|refseq:XP_016865063.1|refseq:XP_016865067.1|refseq:XP_016865068.1|dip:DIP-29936N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:o71OvjzuL/7w4247ap7fm6i3pXU9606 rogid:j5ho+aD4tkX7bXXlROdiprUX1Mc9606 intact-crc:2F9E49C582BB9C1C|rigid:trNYDYqpT7OPgee2YiBJgfHUhqw false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9NWV8 uniprotkb:P08559 intact:EBI-745725|uniprotkb:Q6FIA0|uniprotkb:Q9P018|uniprotkb:A8MQT0|uniprotkb:B4DRY9|uniprotkb:B4DVR1|ensembl:ENSP00000352408|ensembl:ENSP00000470920|ensembl:ENSP00000471605 intact:EBI-715747|uniprotkb:Q9NP12|uniprotkb:Q9UBJ8|uniprotkb:Q9UBU0|uniprotkb:Q9UNG4|uniprotkb:Q9UNG5|uniprotkb:Q5JPT8|uniprotkb:Q53H41|uniprotkb:B2R5P7|uniprotkb:B7Z3T7|uniprotkb:B7Z3X5|uniprotkb:A5YVE9|ensembl:ENSP00000394382 psi-mi:baba1_human(display_long)|uniprotkb:BABAM1(gene name)|psi-mi:BABAM1(display_short)|uniprotkb:HSPC142(orf name)|uniprotkb:C19orf62(gene name synonym)|uniprotkb:NBA1(gene name synonym)|uniprotkb:Mediator of RAP80 interactions and targeting subunit of 40 kDa(gene name synonym)|uniprotkb:New component of the BRCA1-A complex(gene name synonym)|uniprotkb:MERIT40(gene name synonym) psi-mi:odpa_human(display_long)|uniprotkb:PDHE1-A type I(gene name synonym)|uniprotkb:PDHA1(gene name)|psi-mi:PDHA1(display_short)|uniprotkb:PHE1A(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514464|imex:IM-12079-91 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001028721.1|refseq:NP_054892.2|ensembl:ENSG00000105393(gene)|ensembl:ENST00000359435(transcript)|ensembl:ENST00000598188(transcript)|ensembl:ENST00000601043(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006325"(chromatin organization)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016604"(nuclear body)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0051301"(cell division)|go:"GO:0070531"(BRCA1-A complex)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0070552"(BRISC complex)|interpro:IPR026126|interpro:IPR036465|mint:Q9NWV8|rcsb pdb:6H3C|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473|refseq:NP_001275685.1|refseq:NP_001275686.1 refseq:NP_001166926.1|refseq:NP_001166927.1|refseq:NP_000275.1|refseq:NP_001166925.1|ensembl:ENSG00000131828(gene)|ensembl:ENST00000422285(transcript)|go:"GO:0004739"("pyruvate dehydrogenase (acetyl-transferring) activity")|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006086"(acetyl-CoA biosynthetic process from pyruvate)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0034604"("pyruvate dehydrogenase (NAD+) activity")|go:"GO:0045254"(pyruvate dehydrogenase complex)|go:"GO:0061732"(mitochondrial acetyl-CoA biosynthetic process from pyruvate)|interpro:IPR001017(Dehydrogenase, E1 component)|interpro:IPR017597("Pyruvate dehydrogenase (acetyl-transferring) E1 component, alpha subunit, subgroup y")|interpro:IPR029061|rcsb pdb:1NI4|rcsb pdb:2OZL|rcsb pdb:3EXE|rcsb pdb:3EXF|rcsb pdb:3EXG|rcsb pdb:3EXH|rcsb pdb:3EXI|rcsb pdb:6CER|rcsb pdb:6CFO|reactome:R-HSA-204174|reactome:R-HSA-389661|reactome:R-HSA-5362517|reactome:R-HSA-70268|dip:DIP-37652N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:o71OvjzuL/7w4247ap7fm6i3pXU9606 rogid:p4PObFZ4cxJW6ICug+jhlgKlEYY9606 intact-crc:2F9E49C582BB9C1C|rigid:trNYDYqpT7OPgee2YiBJgfHUhqw false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9NWV8 uniprotkb:Q9UN37 intact:EBI-745725|uniprotkb:Q6FIA0|uniprotkb:Q9P018|uniprotkb:A8MQT0|uniprotkb:B4DRY9|uniprotkb:B4DVR1|ensembl:ENSP00000352408|ensembl:ENSP00000470920|ensembl:ENSP00000471605 intact:EBI-1171942|uniprotkb:Q8TF07|uniprotkb:Q9UI03|uniprotkb:Q9Y582|uniprotkb:B2RCB7|ensembl:ENSP00000254950 psi-mi:baba1_human(display_long)|uniprotkb:BABAM1(gene name)|psi-mi:BABAM1(display_short)|uniprotkb:HSPC142(orf name)|uniprotkb:C19orf62(gene name synonym)|uniprotkb:NBA1(gene name synonym)|uniprotkb:Mediator of RAP80 interactions and targeting subunit of 40 kDa(gene name synonym)|uniprotkb:New component of the BRCA1-A complex(gene name synonym)|uniprotkb:MERIT40(gene name synonym) psi-mi:vps4a_human(display_long)|uniprotkb:VPS4-1(gene name synonym)|uniprotkb:Protein SKD2(gene name synonym)|uniprotkb:VPS4A(gene name)|psi-mi:VPS4A(display_short)|uniprotkb:VPS4(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514464|imex:IM-12079-91 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001028721.1|refseq:NP_054892.2|ensembl:ENSG00000105393(gene)|ensembl:ENST00000359435(transcript)|ensembl:ENST00000598188(transcript)|ensembl:ENST00000601043(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006325"(chromatin organization)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016604"(nuclear body)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0051301"(cell division)|go:"GO:0070531"(BRCA1-A complex)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0070552"(BRISC complex)|interpro:IPR026126|interpro:IPR036465|mint:Q9NWV8|rcsb pdb:6H3C|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473|refseq:NP_001275685.1|refseq:NP_001275686.1 refseq:NP_037377.1|ensembl:ENSG00000132612(gene)|ensembl:ENST00000254950(transcript)|go:"GO:0000916"(actomyosin contractile ring contraction)|go:"GO:0000922"(spindle pole)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005774"(vacuolar membrane)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006622"(protein targeting to lysosome)|go:"GO:0006900"(vesicle budding from membrane)|go:"GO:0006997"(nucleus organization)|go:"GO:0006998"(nuclear envelope organization)|go:"GO:0007033"(vacuole organization)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0007084"(mitotic nuclear membrane reassembly)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009838"(abscission)|go:"GO:0010008"(endosome membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016197"(endosomal transport)|go:"GO:0016236"(macroautophagy)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030496"(midbody)|go:"GO:0031468"(nuclear membrane reassembly)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032367"(intracellular cholesterol transport)|go:"GO:0032466"(negative regulation of cytokinesis)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0034058"(endosomal vesicle fusion)|go:"GO:0036258"(multivesicular body assembly)|go:"GO:0039702"(viral budding via host ESCRT complex)|go:"GO:0043162"(ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0044878"(mitotic cytokinesis checkpoint signaling)|go:"GO:0046761"(viral budding from plasma membrane)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051301"(cell division)|go:"GO:0061640"(cytoskeleton-dependent cytokinesis)|go:"GO:0061738"(late endosomal microautophagy)|go:"GO:0061952"(midbody abscission)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072319"(vesicle uncoating)|go:"GO:0090543"(Flemming body)|go:"GO:0090611"(ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0140545"(protein disaggregase activity)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902188"(obsolete positive regulation of viral release from host cell)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1903543"(positive regulation of exosomal secretion)|go:"GO:1903774"(positive regulation of viral budding via host ESCRT complex)|go:"GO:1903902"(positive regulation of viral life cycle)|go:"GO:1904896"(ESCRT complex disassembly)|go:"GO:1904903"(ESCRT III complex disassembly)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR007330(MIT)|interpro:IPR015415(Vps4 oligomerisation, C-terminal)|interpro:IPR027417|interpro:IPR036181|interpro:IPR041569|mint:Q9UN37|rcsb pdb:1YXR|rcsb pdb:2JQ9|rcsb pdb:2K3W|reactome:R-HSA-162588|reactome:R-HSA-917729|reactome:R-HSA-9610379|reactome:R-HSA-9668328|interpro:IPR031255|dip:DIP-44585N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:o71OvjzuL/7w4247ap7fm6i3pXU9606 rogid:kr3zmre/ELTm2b/fCytp8IlBUhs9606 intact-crc:2F9E49C582BB9C1C|rigid:trNYDYqpT7OPgee2YiBJgfHUhqw false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9NWV8 uniprotkb:Q6P4A7 intact:EBI-745725|uniprotkb:Q6FIA0|uniprotkb:Q9P018|uniprotkb:A8MQT0|uniprotkb:B4DRY9|uniprotkb:B4DVR1|ensembl:ENSP00000352408|ensembl:ENSP00000470920|ensembl:ENSP00000471605 intact:EBI-1049439|uniprotkb:Q6WSU4|uniprotkb:Q86TD9|ensembl:ENSP00000347924 psi-mi:baba1_human(display_long)|uniprotkb:BABAM1(gene name)|psi-mi:BABAM1(display_short)|uniprotkb:HSPC142(orf name)|uniprotkb:C19orf62(gene name synonym)|uniprotkb:NBA1(gene name synonym)|uniprotkb:Mediator of RAP80 interactions and targeting subunit of 40 kDa(gene name synonym)|uniprotkb:New component of the BRCA1-A complex(gene name synonym)|uniprotkb:MERIT40(gene name synonym) psi-mi:sfxn4_human(display_long)|uniprotkb:Breast cancer resistance marker 1(gene name synonym)|uniprotkb:SFXN4(gene name)|psi-mi:SFXN4(display_short)|uniprotkb:BCRM1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514464|imex:IM-12079-91 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001028721.1|refseq:NP_054892.2|ensembl:ENSG00000105393(gene)|ensembl:ENST00000359435(transcript)|ensembl:ENST00000598188(transcript)|ensembl:ENST00000601043(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006325"(chromatin organization)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016604"(nuclear body)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0051301"(cell division)|go:"GO:0070531"(BRCA1-A complex)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0070552"(BRISC complex)|interpro:IPR026126|interpro:IPR036465|mint:Q9NWV8|rcsb pdb:6H3C|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473|refseq:NP_001275685.1|refseq:NP_001275686.1 refseq:NP_998814.1|refseq:XP_011537584.1|refseq:XP_005269583.1|refseq:XP_005269584.1|ensembl:ENSG00000183605(gene)|ensembl:ENST00000355697(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0006865"(amino acid transport)|go:"GO:0015075"(ion transmembrane transporter activity)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:1990542"(mitochondrial transmembrane transport)|interpro:IPR004686(Tricarboxylate/iron carrier)|interpro:IPR028825 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:o71OvjzuL/7w4247ap7fm6i3pXU9606 rogid:D/Ae1Kd5aIiliqNVmS7aFaIpwsk9606 intact-crc:2F9E49C582BB9C1C|rigid:trNYDYqpT7OPgee2YiBJgfHUhqw false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9NWV8 uniprotkb:Q9NRN7 intact:EBI-745725|uniprotkb:Q6FIA0|uniprotkb:Q9P018|uniprotkb:A8MQT0|uniprotkb:B4DRY9|uniprotkb:B4DVR1|ensembl:ENSP00000352408|ensembl:ENSP00000470920|ensembl:ENSP00000471605 intact:EBI-740884|ensembl:ENSP00000278618|uniprotkb:Q9C068|uniprotkb:Q9P0Q3|uniprotkb:Q9UG80|uniprotkb:Q9Y389|uniprotkb:B2R6D1|uniprotkb:B4DDW7 psi-mi:baba1_human(display_long)|uniprotkb:BABAM1(gene name)|psi-mi:BABAM1(display_short)|uniprotkb:HSPC142(orf name)|uniprotkb:C19orf62(gene name synonym)|uniprotkb:NBA1(gene name synonym)|uniprotkb:Mediator of RAP80 interactions and targeting subunit of 40 kDa(gene name synonym)|uniprotkb:New component of the BRCA1-A complex(gene name synonym)|uniprotkb:MERIT40(gene name synonym) psi-mi:adppt_human(display_long)|uniprotkb:4'-phosphopantetheinyl transferase(gene name synonym)|uniprotkb:Alpha-aminoadipic semialdehyde dehydrogenase-phosphopantetheinyl transferase(gene name synonym)|uniprotkb:LYS5 ortholog(gene name synonym)|uniprotkb:AASDHPPT(gene name)|psi-mi:AASDHPPT(display_short)|uniprotkb:CGI-80(orf name)|uniprotkb:HAH-P(orf name)|uniprotkb:HSPC223(orf name)|uniprotkb:x0005(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514464|imex:IM-12079-91 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001028721.1|refseq:NP_054892.2|ensembl:ENSG00000105393(gene)|ensembl:ENST00000359435(transcript)|ensembl:ENST00000598188(transcript)|ensembl:ENST00000601043(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006325"(chromatin organization)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016604"(nuclear body)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0051301"(cell division)|go:"GO:0070531"(BRCA1-A complex)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0070552"(BRISC complex)|interpro:IPR026126|interpro:IPR036465|mint:Q9NWV8|rcsb pdb:6H3C|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473|refseq:NP_001275685.1|refseq:NP_001275686.1 refseq:NP_056238.2|ensembl:ENSG00000149313(gene)|ensembl:ENST00000278618(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0005829"(cytosol)|go:"GO:0008897"(holo-[acyl-carrier-protein] synthase activity)|go:"GO:0015939"(pantothenate metabolic process)|go:"GO:0019878"(lysine biosynthetic process via aminoadipic acid)|go:"GO:0070062"(extracellular exosome)|interpro:IPR008278(4'-phosphopantetheinyl transferase)|interpro:IPR037143|rcsb pdb:2BYD|rcsb pdb:2C43|rcsb pdb:2CG5|reactome:R-HSA-199220 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:o71OvjzuL/7w4247ap7fm6i3pXU9606 rogid:0S9gDK0HeJ+8eoM5vHaJDW3THAY9606 intact-crc:2F9E49C582BB9C1C|rigid:trNYDYqpT7OPgee2YiBJgfHUhqw false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9NWV8 uniprotkb:Q99497 intact:EBI-745725|uniprotkb:Q6FIA0|uniprotkb:Q9P018|uniprotkb:A8MQT0|uniprotkb:B4DRY9|uniprotkb:B4DVR1|ensembl:ENSP00000352408|ensembl:ENSP00000470920|ensembl:ENSP00000471605 intact:EBI-1164361|uniprotkb:O14805|uniprotkb:Q6DR95|uniprotkb:Q7LFU2|uniprotkb:B2R4Z1|ensembl:ENSP00000340278|ensembl:ENSP00000366708|ensembl:ENSP00000366711|ensembl:ENSP00000418770|ensembl:ENSP00000465404 psi-mi:baba1_human(display_long)|uniprotkb:BABAM1(gene name)|psi-mi:BABAM1(display_short)|uniprotkb:HSPC142(orf name)|uniprotkb:C19orf62(gene name synonym)|uniprotkb:NBA1(gene name synonym)|uniprotkb:Mediator of RAP80 interactions and targeting subunit of 40 kDa(gene name synonym)|uniprotkb:New component of the BRCA1-A complex(gene name synonym)|uniprotkb:MERIT40(gene name synonym) psi-mi:park7_human(display_long)|uniprotkb:PARK7(gene name)|psi-mi:PARK7(display_short)|uniprotkb:Oncogene DJ1(gene name synonym)|uniprotkb:Parkinsonism-associated deglycase(gene name synonym)|uniprotkb:Maillard deglycase(gene name synonym)|uniprotkb:Protein DJ-1(gene name synonym)|uniprotkb:Protein/nucleic acid deglycase DJ-1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514464|imex:IM-12079-91 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001028721.1|refseq:NP_054892.2|ensembl:ENSG00000105393(gene)|ensembl:ENST00000359435(transcript)|ensembl:ENST00000598188(transcript)|ensembl:ENST00000601043(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006325"(chromatin organization)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016604"(nuclear body)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0051301"(cell division)|go:"GO:0070531"(BRCA1-A complex)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0070552"(BRISC complex)|interpro:IPR026126|interpro:IPR036465|mint:Q9NWV8|rcsb pdb:6H3C|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473|refseq:NP_001275685.1|refseq:NP_001275686.1 refseq:NP_001116849.1|refseq:NP_009193.2|refseq:XP_005263481.1|go:"GO:0046295"(glycolate biosynthetic process)|go:"GO:0046826"(negative regulation of protein export from nucleus)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050787"(detoxification of mercury ion)|go:"GO:0050821"(protein stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051444"(negative regulation of ubiquitin-protein transferase activity)|go:"GO:0051583"(dopamine uptake involved in synaptic transmission)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051899"(membrane depolarization)|go:"GO:0051920"(peroxiredoxin activity)|go:"GO:0060081"(membrane hyperpolarization)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0060765"(regulation of androgen receptor signaling pathway)|go:"GO:0061727"(methylglyoxal catabolic process to lactate)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070994"(detection of oxidative stress)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098793"(presynapse)|go:"GO:0106044"(guanine deglycation)|go:"GO:0106045"(guanine deglycation, methylglyoxal removal)|go:"GO:0106046"(guanine deglycation, glyoxal removal)|go:"GO:0110095"(cellular detoxification of aldehyde)|go:"GO:0140041"(cellular detoxification of methylglyoxal)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901671"(positive regulation of superoxide dismutase activity)|go:"GO:1901984"(negative regulation of protein acetylation)|go:"GO:1902177"(positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1902903"(regulation of supramolecular fiber organization)|go:"GO:1902958"(positive regulation of mitochondrial electron transport, NADH to ubiquinone)|go:"GO:1903073"(negative regulation of death-inducing signaling complex assembly)|go:"GO:1903094"(negative regulation of protein K48-linked deubiquitination)|go:"GO:1903122"(negative regulation of TRAIL-activated apoptotic signaling pathway)|go:"GO:1903135"(cupric ion binding)|go:"GO:1903136"(cuprous ion binding)|go:"GO:1903168"(positive regulation of pyrroline-5-carboxylate reductase activity)|go:"GO:1903178"(positive regulation of tyrosine 3-monooxygenase activity)|go:"GO:1903181"(positive regulation of dopamine biosynthetic process)|go:"GO:1903189"(glyoxal metabolic process)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:1903200"(positive regulation of L-dopa decarboxylase activity)|go:"GO:1903202"(negative regulation of oxidative stress-induced cell death)|go:"GO:1903206"(negative regulation of hydrogen peroxide-induced cell death)|go:"GO:1903208"(negative regulation of hydrogen peroxide-induced neuron death)|go:"GO:1903377"(negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903384"(negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903427"(negative regulation of reactive oxygen species biosynthetic process)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903599"(positive regulation of autophagy of mitochondrion)|go:"GO:1905259"(negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1990381"(ubiquitin-specific protease binding)|go:"GO:1990422"("glyoxalase (glycolic acid-forming) activity")|go:"GO:2000157"(negative regulation of ubiquitin-specific protease activity)|go:"GO:2000277"(positive regulation of oxidative phosphorylation uncoupler activity)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|go:"GO:2000825"(positive regulation of androgen receptor activity)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001268"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR002818(ThiJ/PfpI)|interpro:IPR006287(DJ-1)|interpro:IPR029062|go:"GO:1903197"(positive regulation of L-dopa biosynthetic process)|rcsb pdb:3B36|rcsb pdb:3B38|rcsb pdb:3B3A|rcsb pdb:3BWE|rcsb pdb:3CY6|rcsb pdb:3CYF|rcsb pdb:3CZ9|rcsb pdb:3CZA|rcsb pdb:3EZG|mint:Q99497|rcsb pdb:1J42|rcsb pdb:1P5F|rcsb pdb:3F71|rcsb pdb:1PDV|rcsb pdb:1PDW|rcsb pdb:1PE0|rcsb pdb:1Q2U|rcsb pdb:3SF8|rcsb pdb:1SOA|rcsb pdb:1UCF|rcsb pdb:2OR3|rcsb pdb:2R1T|rcsb pdb:2R1U|rcsb pdb:2R1V|rcsb pdb:4BTE|rcsb pdb:2RK3|rcsb pdb:2RK4|rcsb pdb:2RK6|ensembl:ENSG00000116288(gene)|ensembl:ENST00000338639(transcript)|ensembl:ENST00000377488(transcript)|ensembl:ENST00000377491(transcript)|ensembl:ENST00000493678(transcript)|ensembl:ENST00000493373(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002866"(positive regulation of acute inflammatory response to antigenic stimulus)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003729"(mRNA binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0006281"(DNA repair)|rcsb pdb:4MTC|rcsb pdb:4N0M|rcsb pdb:4N12|rcsb pdb:4OGF|rcsb pdb:4OQ4|rcsb pdb:4P2G|rcsb pdb:4P34|rcsb pdb:4P35|rcsb pdb:4P36|rcsb pdb:4RKW|rcsb pdb:4RKY|rcsb pdb:4S0Z|rcsb pdb:4ZGG|rcsb pdb:5IP5|rcsb pdb:5SY6|rcsb pdb:5SY9|rcsb pdb:5SYA|rcsb pdb:6AF5|rcsb pdb:6AF7|rcsb pdb:6AF9|rcsb pdb:6AFA|rcsb pdb:6AFB|rcsb pdb:6AFC|rcsb pdb:6AFD|rcsb pdb:6AFE|rcsb pdb:6AFF|rcsb pdb:6AFG|rcsb pdb:6AFH|rcsb pdb:6AFI|rcsb pdb:6AFJ|rcsb pdb:6AFL|rcsb pdb:6E5Z|rcsb pdb:6M8Z|rcsb pdb:7C62|reactome:R-HSA-3899300|reactome:R-HSA-9613829|reactome:R-HSA-9615710|reactome:R-HSA-9646399|rcsb pdb:4MNT|go:"GO:0006517"(protein deglycosylation)|go:"GO:0006914"(autophagy)|go:"GO:0006954"(inflammatory response)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007338"(single fertilization)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008233"(peptidase activity)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0009438"(methylglyoxal metabolic process)|go:"GO:0010273"(detoxification of copper ion)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016532"(superoxide dismutase copper chaperone activity)|go:"GO:0016570"(histone modification)|go:"GO:0016605"(PML body)|go:"GO:0016684"(oxidoreductase activity, acting on peroxide as acceptor)|go:"GO:0019249"(lactate biosynthetic process)|go:"GO:0019826"(oxygen sensor activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019955"(cytokine binding)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0030424"(axon)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033182"(regulation of histone ubiquitination)|go:"GO:0033234"(negative regulation of protein sumoylation)|go:"GO:0033864"("positive regulation of NAD(P)H oxidase activity")|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035065"(regulation of histone acetylation)|go:"GO:0036470"(tyrosine 3-monooxygenase activator activity)|go:"GO:0036471"(cellular response to glyoxal)|go:"GO:0036478"(L-dopa decarboxylase activator activity)|go:"GO:0036524"(protein deglycase activity)|go:"GO:0036526"(peptidyl-cysteine deglycation)|go:"GO:0036527"(peptidyl-arginine deglycation)|go:"GO:0036528"(peptidyl-lysine deglycation)|go:"GO:0036529"(protein deglycation, glyoxal removal)|go:"GO:0036530"(protein deglycation, methylglyoxal removal)|go:"GO:0036531"(glutathione deglycation)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042743"(hydrogen peroxide metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044297"(cell body)|go:"GO:0030073"(insulin secretion)|go:"GO:0044388"(small protein activating enzyme binding)|go:"GO:0044390"(ubiquitin-like protein conjugating enzyme binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045296"(cadherin binding)|go:"GO:0045340"(mercury ion binding)|dip:DIP-35515N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:o71OvjzuL/7w4247ap7fm6i3pXU9606 rogid:i5ah4UPCf+4cD51ClZNggMFJMDo9606 intact-crc:2F9E49C582BB9C1C|rigid:trNYDYqpT7OPgee2YiBJgfHUhqw false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9NWV8 uniprotkb:P54619 intact:EBI-745725|uniprotkb:Q6FIA0|uniprotkb:Q9P018|uniprotkb:A8MQT0|uniprotkb:B4DRY9|uniprotkb:B4DVR1|ensembl:ENSP00000352408|ensembl:ENSP00000470920|ensembl:ENSP00000471605 intact:EBI-1181439|ensembl:ENSP00000447433|uniprotkb:B4DDT7|uniprotkb:Q8N7V9 psi-mi:baba1_human(display_long)|uniprotkb:BABAM1(gene name)|psi-mi:BABAM1(display_short)|uniprotkb:HSPC142(orf name)|uniprotkb:C19orf62(gene name synonym)|uniprotkb:NBA1(gene name synonym)|uniprotkb:Mediator of RAP80 interactions and targeting subunit of 40 kDa(gene name synonym)|uniprotkb:New component of the BRCA1-A complex(gene name synonym)|uniprotkb:MERIT40(gene name synonym) psi-mi:aakg1_human(display_long)|uniprotkb:PRKAG1(gene name)|psi-mi:PRKAG1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514464|imex:IM-12079-91 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001028721.1|refseq:NP_054892.2|ensembl:ENSG00000105393(gene)|ensembl:ENST00000359435(transcript)|ensembl:ENST00000598188(transcript)|ensembl:ENST00000601043(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006325"(chromatin organization)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016604"(nuclear body)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0051301"(cell division)|go:"GO:0070531"(BRCA1-A complex)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0070552"(BRISC complex)|interpro:IPR026126|interpro:IPR036465|mint:Q9NWV8|rcsb pdb:6H3C|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473|refseq:NP_001275685.1|refseq:NP_001275686.1 refseq:NP_001193638.1|refseq:NP_001193639.1|refseq:NP_002724.1|refseq:XP_011536864.1|reactome:R-HSA-9619483|reactome:R-HSA-9613354|ensembl:ENSG00000181929(gene)|ensembl:ENST00000548065(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004691"(cAMP-dependent protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006110"(regulation of glycolytic process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008603"(cAMP-dependent protein kinase regulator activity)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0016208"(AMP binding)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043531"(ADP binding)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051170"(import into nucleus)|go:"GO:0071900"(regulation of protein serine/threonine kinase activity)|interpro:IPR000644(Cystathionine beta-synthase, core)|interpro:IPR039166|mint:P54619|rcsb pdb:2UV4|rcsb pdb:2UV5|rcsb pdb:2UV6|rcsb pdb:2UV7|rcsb pdb:4CFE|rcsb pdb:4CFF|rcsb pdb:4RER|rcsb pdb:4REW|rcsb pdb:4ZHX|rcsb pdb:5EZV|rcsb pdb:5ISO|rcsb pdb:6B1U|rcsb pdb:6B2E|rcsb pdb:6C9F|rcsb pdb:6C9G|rcsb pdb:6C9H|rcsb pdb:6C9J|reactome:R-HSA-1445148|reactome:R-HSA-1632852|reactome:R-HSA-2151209|reactome:R-HSA-380972|reactome:R-HSA-5628897|reactome:R-HSA-6804756|refseq:XP_006719562.1|dip:DIP-39974N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:o71OvjzuL/7w4247ap7fm6i3pXU9606 rogid:JNBzPdCbcgr37RKb2sk6yVL+7649606 intact-crc:2F9E49C582BB9C1C|rigid:trNYDYqpT7OPgee2YiBJgfHUhqw false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9NWV8 uniprotkb:P34897 intact:EBI-745725|uniprotkb:Q6FIA0|uniprotkb:Q9P018|uniprotkb:A8MQT0|uniprotkb:B4DRY9|uniprotkb:B4DVR1|ensembl:ENSP00000352408|ensembl:ENSP00000470920|ensembl:ENSP00000471605 intact:EBI-352908|ensembl:ENSP00000333667|uniprotkb:O00740|uniprotkb:Q8N1A5|uniprotkb:B7Z9F1|uniprotkb:E7EQ19|uniprotkb:E7EU43 psi-mi:baba1_human(display_long)|uniprotkb:BABAM1(gene name)|psi-mi:BABAM1(display_short)|uniprotkb:HSPC142(orf name)|uniprotkb:C19orf62(gene name synonym)|uniprotkb:NBA1(gene name synonym)|uniprotkb:Mediator of RAP80 interactions and targeting subunit of 40 kDa(gene name synonym)|uniprotkb:New component of the BRCA1-A complex(gene name synonym)|uniprotkb:MERIT40(gene name synonym) psi-mi:glym_human(display_long)|uniprotkb:SHMT2(gene name)|psi-mi:SHMT2(display_short)|uniprotkb:Glycine hydroxymethyltransferase(gene name synonym)|uniprotkb:Serine methylase(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514464|imex:IM-12079-91 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001028721.1|refseq:NP_054892.2|ensembl:ENSG00000105393(gene)|ensembl:ENST00000359435(transcript)|ensembl:ENST00000598188(transcript)|ensembl:ENST00000601043(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006325"(chromatin organization)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016604"(nuclear body)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0051301"(cell division)|go:"GO:0070531"(BRCA1-A complex)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0070552"(BRISC complex)|interpro:IPR026126|interpro:IPR036465|mint:Q9NWV8|rcsb pdb:6H3C|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473|refseq:NP_001275685.1|refseq:NP_001275686.1 ensembl:ENSG00000182199(gene)|ensembl:ENST00000328923(transcript)|go:"GO:0000900"(translation repressor activity, mRNA regulatory element binding)|go:"GO:0002082"(regulation of oxidative phosphorylation)|go:"GO:0003682"(chromatin binding)|go:"GO:0004372"(glycine hydroxymethyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006544"(glycine metabolic process)|go:"GO:0006563"(L-serine metabolic process)|go:"GO:0006564"(L-serine biosynthetic process)|go:"GO:0006565"(L-serine catabolic process)|go:"GO:0006730"(one-carbon metabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008732"(L-allo-threonine aldolase activity)|go:"GO:0009113"(purine nucleobase biosynthetic process)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0019264"(glycine biosynthetic process from serine)|go:"GO:0030170"(pyridoxal phosphate binding)|go:"GO:0034340"(response to type I interferon)|go:"GO:0035999"(tetrahydrofolate interconversion)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046653"(tetrahydrofolate metabolic process)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0050897"(cobalt ion binding)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070129"(regulation of mitochondrial translation)|go:"GO:0046655"(folic acid metabolic process)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0070552"(BRISC complex)|go:"GO:0070905"(serine binding)|go:"GO:1903715"(regulation of aerobic respiration)|interpro:IPR001085(Glycine hydroxymethyltransferase)|interpro:IPR015421(Pyridoxal phosphate-dependent transferase, major region, subdomain 1)|interpro:IPR015422(Pyridoxal phosphate-dependent transferase, major region, subdomain 2)|interpro:IPR015424(Pyridoxal phosphate-dependent transferase, major region)|interpro:IPR019798|interpro:IPR039429|mint:P34897|rcsb pdb:4PVF|rcsb pdb:5V7I|rcsb pdb:5X3V|rcsb pdb:6DK3|rcsb pdb:6H3C|rcsb pdb:6M5O|rcsb pdb:6QVG|rcsb pdb:6QVL|rcsb pdb:6R8F|reactome:R-HSA-196757|reactome:R-HSA-9013408|refseq:NP_001159829.1|refseq:NP_001159830.1|refseq:NP_001159831.1|refseq:NP_005403.2|refseq:NP_001159828.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:o71OvjzuL/7w4247ap7fm6i3pXU9606 rogid:Ce7izVDbUDULaGUe2fZWlikUZFk9606 intact-crc:2F9E49C582BB9C1C|rigid:trNYDYqpT7OPgee2YiBJgfHUhqw false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9NWV8 uniprotkb:Q9NYU1 intact:EBI-745725|uniprotkb:Q6FIA0|uniprotkb:Q9P018|uniprotkb:A8MQT0|uniprotkb:B4DRY9|uniprotkb:B4DVR1|ensembl:ENSP00000352408|ensembl:ENSP00000470920|ensembl:ENSP00000471605 intact:EBI-1054215|uniprotkb:Q5JQR8|uniprotkb:Q9UFC4|uniprotkb:Q08AD0|uniprotkb:A6NKL4|uniprotkb:Q8N5K0|ensembl:ENSP00000365938 psi-mi:baba1_human(display_long)|uniprotkb:BABAM1(gene name)|psi-mi:BABAM1(display_short)|uniprotkb:HSPC142(orf name)|uniprotkb:C19orf62(gene name synonym)|uniprotkb:NBA1(gene name synonym)|uniprotkb:Mediator of RAP80 interactions and targeting subunit of 40 kDa(gene name synonym)|uniprotkb:New component of the BRCA1-A complex(gene name synonym)|uniprotkb:MERIT40(gene name synonym) psi-mi:uggg2_human(display_long)|uniprotkb:UDP-glucose ceramide glucosyltransferase-like 1(gene name synonym)|uniprotkb:"UDP--Glc:glycoprotein glucosyltransferase 2"(gene name synonym)|uniprotkb:UGGT2(gene name)|psi-mi:UGGT2(display_short)|uniprotkb:UGT2(gene name synonym)|uniprotkb:UGCGL2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514464|imex:IM-12079-91 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001028721.1|refseq:NP_054892.2|ensembl:ENSG00000105393(gene)|ensembl:ENST00000359435(transcript)|ensembl:ENST00000598188(transcript)|ensembl:ENST00000601043(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006325"(chromatin organization)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016604"(nuclear body)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0051301"(cell division)|go:"GO:0070531"(BRCA1-A complex)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0070552"(BRISC complex)|interpro:IPR026126|interpro:IPR036465|mint:Q9NWV8|rcsb pdb:6H3C|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473|refseq:NP_001275685.1|refseq:NP_001275686.1 refseq:NP_064506.3|ensembl:ENSG00000102595(gene)|ensembl:ENST00000376747(transcript)|go:"GO:0003980"("UDP-glucose:glycoprotein glucosyltransferase activity")|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0018279"(protein N-linked glycosylation via asparagine)|go:"GO:0032991"(protein-containing complex)|go:"GO:0044322"(endoplasmic reticulum quality control compartment)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0071712"(ER-associated misfolded protein catabolic process)|go:"GO:1904380"(endoplasmic reticulum mannose trimming)|interpro:IPR009448("UDP-glucose:Glycoprotein Glucosyltransferase")|interpro:IPR029044|interpro:IPR040497|interpro:IPR040525|interpro:IPR040692|interpro:IPR040693|interpro:IPR040694|reactome:R-HSA-901032 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:o71OvjzuL/7w4247ap7fm6i3pXU9606 rogid:jEO6Ao5a4/iJg3Y1DeBydzHDYWM9606 intact-crc:2F9E49C582BB9C1C|rigid:trNYDYqpT7OPgee2YiBJgfHUhqw false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9NWV8 uniprotkb:O14925 intact:EBI-745725|uniprotkb:Q6FIA0|uniprotkb:Q9P018|uniprotkb:A8MQT0|uniprotkb:B4DRY9|uniprotkb:B4DVR1|ensembl:ENSP00000352408|ensembl:ENSP00000470920|ensembl:ENSP00000471605 intact:EBI-1047996|uniprotkb:Q53FF8|uniprotkb:Q6P5S5|uniprotkb:Q5T1E6|ensembl:ENSP00000464522 psi-mi:baba1_human(display_long)|uniprotkb:BABAM1(gene name)|psi-mi:BABAM1(display_short)|uniprotkb:HSPC142(orf name)|uniprotkb:C19orf62(gene name synonym)|uniprotkb:NBA1(gene name synonym)|uniprotkb:Mediator of RAP80 interactions and targeting subunit of 40 kDa(gene name synonym)|uniprotkb:New component of the BRCA1-A complex(gene name synonym)|uniprotkb:MERIT40(gene name synonym) psi-mi:tim23_human(display_long)|uniprotkb:TIMM23(gene name)|psi-mi:TIMM23(display_short)|uniprotkb:TIM23(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514464|imex:IM-12079-91 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001028721.1|refseq:NP_054892.2|ensembl:ENSG00000105393(gene)|ensembl:ENST00000359435(transcript)|ensembl:ENST00000598188(transcript)|ensembl:ENST00000601043(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006325"(chromatin organization)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016604"(nuclear body)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0051301"(cell division)|go:"GO:0070531"(BRCA1-A complex)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0070552"(BRISC complex)|interpro:IPR026126|interpro:IPR036465|mint:Q9NWV8|rcsb pdb:6H3C|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473|refseq:NP_001275685.1|refseq:NP_001275686.1 refseq:NP_006318.1|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0008320"(protein transmembrane transporter activity)|go:"GO:0030150"(protein import into mitochondrial matrix)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|interpro:IPR005681(Mitochondrial import inner membrane translocase, subunit Tim23)|mint:O14925|reactome:R-HSA-1268020|ensembl:ENSG00000265354(gene)|ensembl:ENST00000580018(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005744"(TIM23 mitochondrial import inner membrane translocase complex) psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:o71OvjzuL/7w4247ap7fm6i3pXU9606 rogid:Hmu/kwfaPLGFGYBJH0oue7JDYqM9606 intact-crc:2F9E49C582BB9C1C|rigid:trNYDYqpT7OPgee2YiBJgfHUhqw false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9NWV8 uniprotkb:O75351 intact:EBI-745725|uniprotkb:Q6FIA0|uniprotkb:Q9P018|uniprotkb:A8MQT0|uniprotkb:B4DRY9|uniprotkb:B4DVR1|ensembl:ENSP00000352408|ensembl:ENSP00000470920|ensembl:ENSP00000471605 intact:EBI-2514459|ensembl:ENSP00000238497|uniprotkb:Q9GZS7|uniprotkb:Q69HW4 psi-mi:baba1_human(display_long)|uniprotkb:BABAM1(gene name)|psi-mi:BABAM1(display_short)|uniprotkb:HSPC142(orf name)|uniprotkb:C19orf62(gene name synonym)|uniprotkb:NBA1(gene name synonym)|uniprotkb:Mediator of RAP80 interactions and targeting subunit of 40 kDa(gene name synonym)|uniprotkb:New component of the BRCA1-A complex(gene name synonym)|uniprotkb:MERIT40(gene name synonym) psi-mi:vps4b_human(display_long)|uniprotkb:VPS4B(gene name)|psi-mi:VPS4B(display_short)|uniprotkb:SKD1(gene name synonym)|uniprotkb:VPS42(gene name synonym)|uniprotkb:"Suppressor of K(+) transport growth defect 1"(gene name synonym)|uniprotkb:Cell migration-inducing gene 1 protein(gene name synonym)|uniprotkb:MIG1(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514464|imex:IM-12079-91 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001028721.1|refseq:NP_054892.2|ensembl:ENSG00000105393(gene)|ensembl:ENST00000359435(transcript)|ensembl:ENST00000598188(transcript)|ensembl:ENST00000601043(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006325"(chromatin organization)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016604"(nuclear body)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0051301"(cell division)|go:"GO:0070531"(BRCA1-A complex)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0070552"(BRISC complex)|interpro:IPR026126|interpro:IPR036465|mint:Q9NWV8|rcsb pdb:6H3C|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473|refseq:NP_001275685.1|refseq:NP_001275686.1 ensembl:ENSG00000119541(gene)|ensembl:ENST00000238497(transcript)|go:"GO:0000922"(spindle pole)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006997"(nucleus organization)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008568"(microtubule-severing ATPase activity)|go:"GO:0010008"(endosome membrane)|go:"GO:0010824"(regulation of centrosome duplication)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0015031"(protein transport)|go:"GO:0016197"(endosomal transport)|go:"GO:0016236"(macroautophagy)|go:"GO:0030301"(cholesterol transport)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032510"(endosome to lysosome transport via multivesicular body sorting pathway)|go:"GO:0033993"(response to lipid)|go:"GO:0036258"(multivesicular body assembly)|go:"GO:0039702"(viral budding via host ESCRT complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043162"(ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046761"(viral budding from plasma membrane)|go:"GO:0051261"(protein depolymerization)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061738"(late endosomal microautophagy)|go:"GO:0061952"(midbody abscission)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090543"(Flemming body)|go:"GO:0090611"(ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1901673"(regulation of mitotic spindle assembly)|go:"GO:1903542"(negative regulation of exosomal secretion)|go:"GO:1903543"(positive regulation of exosomal secretion)|go:"GO:1903724"(positive regulation of centriole elongation)|go:"GO:1904903"(ESCRT III complex disassembly)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR007330(MIT)|interpro:IPR015415(Vps4 oligomerisation, C-terminal)|interpro:IPR027417|interpro:IPR031255|interpro:IPR036181|interpro:IPR041569|rcsb pdb:1WR0|rcsb pdb:1XWI|rcsb pdb:2CPT|rcsb pdb:2JQH|rcsb pdb:2JQK|rcsb pdb:4U7Y|rcsb pdb:7L9X|reactome:R-HSA-162588|reactome:R-HSA-917729|refseq:NP_004860.2|dip:DIP-53790N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:o71OvjzuL/7w4247ap7fm6i3pXU9606 rogid:BBEuP035ynUSYZcCp76bTduLz589606 intact-crc:2F9E49C582BB9C1C|rigid:trNYDYqpT7OPgee2YiBJgfHUhqw false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9NWV8 uniprotkb:Q9UJS0 intact:EBI-745725|uniprotkb:Q6FIA0|uniprotkb:Q9P018|uniprotkb:A8MQT0|uniprotkb:B4DRY9|uniprotkb:B4DVR1|ensembl:ENSP00000352408|ensembl:ENSP00000470920|ensembl:ENSP00000471605 intact:EBI-1222503|uniprotkb:O14566|uniprotkb:O14575|uniprotkb:Q9NZW1|uniprotkb:Q9UNI7|uniprotkb:Q546F9|ensembl:ENSP00000265631 psi-mi:baba1_human(display_long)|uniprotkb:BABAM1(gene name)|psi-mi:BABAM1(display_short)|uniprotkb:HSPC142(orf name)|uniprotkb:C19orf62(gene name synonym)|uniprotkb:NBA1(gene name synonym)|uniprotkb:Mediator of RAP80 interactions and targeting subunit of 40 kDa(gene name synonym)|uniprotkb:New component of the BRCA1-A complex(gene name synonym)|uniprotkb:MERIT40(gene name synonym) psi-mi:cmc2_human(display_long)|uniprotkb:SLC25A13(gene name)|psi-mi:SLC25A13(display_short)|uniprotkb:ARALAR2(gene name synonym)|uniprotkb:Mitochondrial aspartate glutamate carrier 2(gene name synonym)|uniprotkb:Solute carrier family 25 member 13(gene name synonym)|uniprotkb:Citrin(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514464|imex:IM-12079-91 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001028721.1|refseq:NP_054892.2|ensembl:ENSG00000105393(gene)|ensembl:ENST00000359435(transcript)|ensembl:ENST00000598188(transcript)|ensembl:ENST00000601043(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006325"(chromatin organization)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016604"(nuclear body)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0051301"(cell division)|go:"GO:0070531"(BRCA1-A complex)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0070552"(BRISC complex)|interpro:IPR026126|interpro:IPR036465|mint:Q9NWV8|rcsb pdb:6H3C|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473|refseq:NP_001275685.1|refseq:NP_001275686.1 refseq:NP_055066.1|refseq:NP_001153682.1|go:"GO:0005313"(L-glutamate transmembrane transporter activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0006839"(mitochondrial transport)|go:"GO:0009066"(aspartate family amino acid metabolic process)|go:"GO:0015172"(acidic amino acid transmembrane transporter activity)|go:"GO:0015183"(L-aspartate transmembrane transporter activity)|go:"GO:0015810"(aspartate transmembrane transport)|go:"GO:0015813"(L-glutamate transmembrane transport)|go:"GO:0022857"(transmembrane transporter activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043490"(malate-aspartate shuttle)|go:"GO:0045333"(cellular respiration)|go:"GO:0051592"(response to calcium ion)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR002067(Mitochondrial carrier protein)|interpro:IPR011992(EF-Hand type)|interpro:IPR018108|interpro:IPR023395|interpro:IPR029658|mint:Q9UJS0|rcsb pdb:4P5W|reactome:R-HSA-1268020|reactome:R-HSA-70263|reactome:R-HSA-8963693|ensembl:ENSG00000004864(gene)|ensembl:ENST00000265631(transcript) psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:o71OvjzuL/7w4247ap7fm6i3pXU9606 rogid:YtrKzkRujsJ/hzl2bJaLgJAAswI9606 intact-crc:2F9E49C582BB9C1C|rigid:trNYDYqpT7OPgee2YiBJgfHUhqw false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9NWV8 uniprotkb:Q14680 intact:EBI-745725|uniprotkb:Q6FIA0|uniprotkb:Q9P018|uniprotkb:A8MQT0|uniprotkb:B4DRY9|uniprotkb:B4DVR1|ensembl:ENSP00000352408|ensembl:ENSP00000470920|ensembl:ENSP00000471605 intact:EBI-1046702|uniprotkb:Q7L3C3|ensembl:ENSP00000298048|uniprotkb:D3DRP8|uniprotkb:B1AMQ6|uniprotkb:B7Z6Y0|uniprotkb:B7Z7Q1|uniprotkb:A6P3A7|uniprotkb:A6P3A8|uniprotkb:B7Z6R8|uniprotkb:B7Z1E6|uniprotkb:F5H2R4|uniprotkb:B7Z5M5|uniprotkb:B7Z6Q7|uniprotkb:F5H0Y0|uniprotkb:F5H689 psi-mi:baba1_human(display_long)|uniprotkb:BABAM1(gene name)|psi-mi:BABAM1(display_short)|uniprotkb:HSPC142(orf name)|uniprotkb:C19orf62(gene name synonym)|uniprotkb:NBA1(gene name synonym)|uniprotkb:Mediator of RAP80 interactions and targeting subunit of 40 kDa(gene name synonym)|uniprotkb:New component of the BRCA1-A complex(gene name synonym)|uniprotkb:MERIT40(gene name synonym) psi-mi:melk_human(display_long)|uniprotkb:Protein kinase PK38(gene name synonym)|uniprotkb:MELK(gene name)|psi-mi:MELK(display_short)|uniprotkb:KIAA0175(gene name synonym)|uniprotkb:Protein kinase Eg3(gene name synonym)|uniprotkb:Tyrosine-protein kinase MELK(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514464|imex:IM-12079-91 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001028721.1|refseq:NP_054892.2|ensembl:ENSG00000105393(gene)|ensembl:ENST00000359435(transcript)|ensembl:ENST00000598188(transcript)|ensembl:ENST00000601043(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006325"(chromatin organization)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016604"(nuclear body)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0051301"(cell division)|go:"GO:0070531"(BRCA1-A complex)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0070552"(BRISC complex)|interpro:IPR026126|interpro:IPR036465|mint:Q9NWV8|rcsb pdb:6H3C|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473|refseq:NP_001275685.1|refseq:NP_001275686.1 ensembl:ENSG00000165304(gene)|ensembl:ENST00000298048(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008289"(lipid binding)|go:"GO:0008631"(intrinsic apoptotic signaling pathway in response to oxidative stress)|go:"GO:0016020"(membrane)|go:"GO:0030097"(hemopoiesis)|rcsb pdb:4D2T|rcsb pdb:4D2V|rcsb pdb:4D2W|rcsb pdb:4IXP|rcsb pdb:4UMP|rcsb pdb:4UMQ|rcsb pdb:4UMR|rcsb pdb:4UMT|rcsb pdb:4UMU|rcsb pdb:5IH8|rcsb pdb:5IH9|rcsb pdb:5IHA|rcsb pdb:5IHC|rcsb pdb:5K00|rcsb pdb:5M5A|rcsb pdb:5MAF|rcsb pdb:5MAG|rcsb pdb:5MAH|rcsb pdb:5MAI|refseq:NP_055606.1|rcsb pdb:5TVT|rcsb pdb:5TWL|rcsb pdb:5TWU|rcsb pdb:5TWY|rcsb pdb:5TWZ|rcsb pdb:5TX3|rcsb pdb:6GVX|rcsb pdb:6VXR|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0061351"(neural precursor cell proliferation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001772(Kinase-associated KA1)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028375|interpro:IPR034673|rcsb pdb:4BKY|rcsb pdb:4BKZ|rcsb pdb:4BL1|rcsb pdb:4D2P|refseq:XP_011516386.1|refseq:XP_011516378.1|refseq:XP_011516379.1|refseq:XP_011516380.1|refseq:XP_011516381.1|refseq:XP_011516383.1|refseq:XP_011516384.1|refseq:XP_011516385.1|refseq:NP_001243614.1|refseq:NP_001243616.1|refseq:NP_001243617.1|refseq:NP_001243621.1|refseq:NP_001243622.1|refseq:NP_001243618.1|refseq:NP_001243619.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:o71OvjzuL/7w4247ap7fm6i3pXU9606 rogid:hGuk/IC9/WA3vu9lXaW2F6YWCpU9606 intact-crc:2F9E49C582BB9C1C|rigid:trNYDYqpT7OPgee2YiBJgfHUhqw false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9NWV8 uniprotkb:P46736 intact:EBI-745725|uniprotkb:Q6FIA0|uniprotkb:Q9P018|uniprotkb:A8MQT0|uniprotkb:B4DRY9|uniprotkb:B4DVR1|ensembl:ENSP00000352408|ensembl:ENSP00000470920|ensembl:ENSP00000471605 intact:EBI-750352|uniprotkb:Q16107|uniprotkb:Q9BTZ6|uniprotkb:A6QRF8|uniprotkb:A6QRF9|uniprotkb:A8MUX5|uniprotkb:A8MWH0|uniprotkb:A9Z1Y0|uniprotkb:A9Z1Y5|uniprotkb:B1B062|uniprotkb:B4DQN7|uniprotkb:Q53YX5|ensembl:ENSP00000358474 psi-mi:baba1_human(display_long)|uniprotkb:BABAM1(gene name)|psi-mi:BABAM1(display_short)|uniprotkb:HSPC142(orf name)|uniprotkb:C19orf62(gene name synonym)|uniprotkb:NBA1(gene name synonym)|uniprotkb:Mediator of RAP80 interactions and targeting subunit of 40 kDa(gene name synonym)|uniprotkb:New component of the BRCA1-A complex(gene name synonym)|uniprotkb:MERIT40(gene name synonym) psi-mi:brcc3_human(display_long)|uniprotkb:BRCC3(gene name)|psi-mi:BRCC3(display_short)|uniprotkb:C6.1A(gene name synonym)|uniprotkb:CXorf53(gene name synonym)|uniprotkb:BRCC36(gene name synonym)|uniprotkb:BRCA1-A complex subunit BRCC36(gene name synonym)|uniprotkb:BRISC complex subunit BRCC36(gene name synonym)|uniprotkb:BRCA1/BRCA2-containing complex subunit 3(gene name synonym)|uniprotkb:BRCA1/BRCA2-containing complex subunit 36(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514464|imex:IM-12079-91 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001028721.1|refseq:NP_054892.2|ensembl:ENSG00000105393(gene)|ensembl:ENST00000359435(transcript)|ensembl:ENST00000598188(transcript)|ensembl:ENST00000601043(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006325"(chromatin organization)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016604"(nuclear body)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0051301"(cell division)|go:"GO:0070531"(BRCA1-A complex)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0070552"(BRISC complex)|interpro:IPR026126|interpro:IPR036465|mint:Q9NWV8|rcsb pdb:6H3C|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473|refseq:NP_001275685.1|refseq:NP_001275686.1 refseq:NP_001018065.1|refseq:NP_001229569.1|refseq:NP_077308.1|refseq:XP_016885327.1|dip:DIP-48719N|ensembl:ENSG00000185515(gene)|go:"GO:0000152"(nuclear ubiquitin ligase complex)|go:"GO:0000922"(spindle pole)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0010165"(response to X-ray)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0046872"(metal ion binding)|go:"GO:0051301"(cell division)|go:"GO:0061578"(Lys63-specific deubiquitinase activity)|go:"GO:0070122"(isopeptidase activity)|ensembl:ENST00000369462(transcript)|go:"GO:0070531"(BRCA1-A complex)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0070537"(histone H2A K63-linked deubiquitination)|go:"GO:0070552"(BRISC complex)|go:"GO:0000151"(ubiquitin ligase complex)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR033860|interpro:IPR037518|interpro:IPR040749|mint:P46736|rcsb pdb:6H3C|rcsb pdb:6R8F|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473 psi-mi:"MI:0469"(intact) - caution:This sequence has been withdrawn from Uniprot.|crc64:5720358C1A2F7421 figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:o71OvjzuL/7w4247ap7fm6i3pXU9606 rogid:4YP0TYSnZOZQ4mFEmr07XIx+AVw9606 intact-crc:2F9E49C582BB9C1C|rigid:trNYDYqpT7OPgee2YiBJgfHUhqw false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9NWV8 uniprotkb:Q8TD30 intact:EBI-745725|uniprotkb:Q6FIA0|uniprotkb:Q9P018|uniprotkb:A8MQT0|uniprotkb:B4DRY9|uniprotkb:B4DVR1|ensembl:ENSP00000352408|ensembl:ENSP00000470920|ensembl:ENSP00000471605 intact:EBI-2512017|ensembl:ENSP00000345282|uniprotkb:Q8N9E2 psi-mi:baba1_human(display_long)|uniprotkb:BABAM1(gene name)|psi-mi:BABAM1(display_short)|uniprotkb:HSPC142(orf name)|uniprotkb:C19orf62(gene name synonym)|uniprotkb:NBA1(gene name synonym)|uniprotkb:Mediator of RAP80 interactions and targeting subunit of 40 kDa(gene name synonym)|uniprotkb:New component of the BRCA1-A complex(gene name synonym)|uniprotkb:MERIT40(gene name synonym) psi-mi:alat2_human(display_long)|uniprotkb:GPT2(gene name)|psi-mi:GPT2(display_short)|uniprotkb:AAT2(gene name synonym)|uniprotkb:ALT2(gene name synonym)|uniprotkb:Glutamic--pyruvic transaminase 2(gene name synonym)|uniprotkb:Glutamate pyruvate transaminase 2(gene name synonym)|uniprotkb:Glutamic--alanine transaminase 2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514464|imex:IM-12079-91 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001028721.1|refseq:NP_054892.2|ensembl:ENSG00000105393(gene)|ensembl:ENST00000359435(transcript)|ensembl:ENST00000598188(transcript)|ensembl:ENST00000601043(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006325"(chromatin organization)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016604"(nuclear body)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0051301"(cell division)|go:"GO:0070531"(BRCA1-A complex)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0070552"(BRISC complex)|interpro:IPR026126|interpro:IPR036465|mint:Q9NWV8|rcsb pdb:6H3C|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473|refseq:NP_001275685.1|refseq:NP_001275686.1 ensembl:ENSG00000166123(gene)|ensembl:ENST00000340124(transcript)|go:"GO:0004021"("L-alanine:2-oxoglutarate aminotransferase activity")|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006103"(2-oxoglutarate metabolic process)|go:"GO:0009058"(biosynthetic process)|go:"GO:0030170"(pyridoxal phosphate binding)|go:"GO:0042851"(L-alanine metabolic process)|go:"GO:0042853"(L-alanine catabolic process)|interpro:IPR004839(Aminotransferase, class I and II)|interpro:IPR015421(Pyridoxal phosphate-dependent transferase, major region, subdomain 1)|interpro:IPR015422(Pyridoxal phosphate-dependent transferase, major region, subdomain 2)|interpro:IPR015424(Pyridoxal phosphate-dependent transferase, major region)|rcsb pdb:3IHJ|reactome:R-HSA-8964540|refseq:NP_001135938.1|refseq:NP_597700.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:o71OvjzuL/7w4247ap7fm6i3pXU9606 rogid:y1b6AvLMwS7WNYKP9r2gwU2BeR49606 intact-crc:2F9E49C582BB9C1C|rigid:trNYDYqpT7OPgee2YiBJgfHUhqw false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9NWV8 uniprotkb:Q96ND0 intact:EBI-745725|uniprotkb:Q6FIA0|uniprotkb:Q9P018|uniprotkb:A8MQT0|uniprotkb:B4DRY9|uniprotkb:B4DVR1|ensembl:ENSP00000352408|ensembl:ENSP00000470920|ensembl:ENSP00000471605 intact:EBI-2514451|ensembl:ENSP00000323635|ensembl:ENSP00000386115|ensembl:ENSP00000498370|uniprotkb:D3DUJ4 psi-mi:baba1_human(display_long)|uniprotkb:BABAM1(gene name)|psi-mi:BABAM1(display_short)|uniprotkb:HSPC142(orf name)|uniprotkb:C19orf62(gene name synonym)|uniprotkb:NBA1(gene name synonym)|uniprotkb:Mediator of RAP80 interactions and targeting subunit of 40 kDa(gene name synonym)|uniprotkb:New component of the BRCA1-A complex(gene name synonym)|uniprotkb:MERIT40(gene name synonym) psi-mi:f210a_human(display_long)|uniprotkb:FAM210A(gene name)|psi-mi:FAM210A(display_short)|uniprotkb:C18orf19(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514464|imex:IM-12079-91 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001028721.1|refseq:NP_054892.2|ensembl:ENSG00000105393(gene)|ensembl:ENST00000359435(transcript)|ensembl:ENST00000598188(transcript)|ensembl:ENST00000601043(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006325"(chromatin organization)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016604"(nuclear body)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0051301"(cell division)|go:"GO:0070531"(BRCA1-A complex)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0070552"(BRISC complex)|interpro:IPR026126|interpro:IPR036465|mint:Q9NWV8|rcsb pdb:6H3C|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473|refseq:NP_001275685.1|refseq:NP_001275686.1 ensembl:ENSG00000177150(gene)|ensembl:ENST00000322247(transcript)|ensembl:ENST00000402563(transcript)|ensembl:ENST00000651643(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0016021"(integral component of membrane)|interpro:IPR009688(Protein of unknown function DUF1279)|refseq:NP_001092271.1|refseq:NP_689565.2 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:o71OvjzuL/7w4247ap7fm6i3pXU9606 rogid:IfM9onvsDCP8sih6fKCFCyfwpJk9606 intact-crc:2F9E49C582BB9C1C|rigid:trNYDYqpT7OPgee2YiBJgfHUhqw false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9NWV8 uniprotkb:Q02978 intact:EBI-745725|uniprotkb:Q6FIA0|uniprotkb:Q9P018|uniprotkb:A8MQT0|uniprotkb:B4DRY9|uniprotkb:B4DVR1|ensembl:ENSP00000352408|ensembl:ENSP00000470920|ensembl:ENSP00000471605 intact:EBI-359174|uniprotkb:O75537|uniprotkb:Q969P7|ensembl:ENSP00000225665|uniprotkb:F5GY65 psi-mi:baba1_human(display_long)|uniprotkb:BABAM1(gene name)|psi-mi:BABAM1(display_short)|uniprotkb:HSPC142(orf name)|uniprotkb:C19orf62(gene name synonym)|uniprotkb:NBA1(gene name synonym)|uniprotkb:Mediator of RAP80 interactions and targeting subunit of 40 kDa(gene name synonym)|uniprotkb:New component of the BRCA1-A complex(gene name synonym)|uniprotkb:MERIT40(gene name synonym) psi-mi:m2om_human(display_long)|uniprotkb:SLC25A11(gene name)|psi-mi:SLC25A11(display_short)|uniprotkb:SLC20A4(gene name synonym)|uniprotkb:Solute carrier family 25 member 11(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514464|imex:IM-12079-91 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001028721.1|refseq:NP_054892.2|ensembl:ENSG00000105393(gene)|ensembl:ENST00000359435(transcript)|ensembl:ENST00000598188(transcript)|ensembl:ENST00000601043(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006325"(chromatin organization)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016604"(nuclear body)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0051301"(cell division)|go:"GO:0070531"(BRCA1-A complex)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0070552"(BRISC complex)|interpro:IPR026126|interpro:IPR036465|mint:Q9NWV8|rcsb pdb:6H3C|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473|refseq:NP_001275685.1|refseq:NP_001275686.1 refseq:NP_003553.2|go:"GO:0071423"(malate transmembrane transport)|interpro:IPR018108|interpro:IPR023395|mint:Q02978|reactome:R-HSA-70263|ensembl:ENSG00000108528(gene)|ensembl:ENST00000225665(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008272"(sulfate transport)|go:"GO:0015116"(sulfate transmembrane transporter activity)|go:"GO:0015117"(thiosulfate transmembrane transporter activity)|go:"GO:0015131"(oxaloacetate transmembrane transporter activity)|go:"GO:0015140"(malate transmembrane transporter activity)|go:"GO:0015141"(succinate transmembrane transporter activity)|go:"GO:0015297"(antiporter activity)|go:"GO:0015367"("oxoglutarate:malate antiporter activity")|go:"GO:0015709"(thiosulfate transport)|go:"GO:0015729"(oxaloacetate transport)|go:"GO:0035435"(phosphate ion transmembrane transport)|go:"GO:0071422"(succinate transmembrane transport) psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:o71OvjzuL/7w4247ap7fm6i3pXU9606 rogid:TPeF6k/rQq+WJ9omeDK4V6NY4/o9606 intact-crc:2F9E49C582BB9C1C|rigid:trNYDYqpT7OPgee2YiBJgfHUhqw false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9NWV8 uniprotkb:B5MD87 intact:EBI-745725|uniprotkb:Q6FIA0|uniprotkb:Q9P018|uniprotkb:A8MQT0|uniprotkb:B4DRY9|uniprotkb:B4DVR1|ensembl:ENSP00000352408|ensembl:ENSP00000470920|ensembl:ENSP00000471605 intact:EBI-2514447|ensembl:ENSP00000366802|ensembl:ENSP00000487676 psi-mi:baba1_human(display_long)|uniprotkb:BABAM1(gene name)|psi-mi:BABAM1(display_short)|uniprotkb:HSPC142(orf name)|uniprotkb:C19orf62(gene name synonym)|uniprotkb:NBA1(gene name synonym)|uniprotkb:Mediator of RAP80 interactions and targeting subunit of 40 kDa(gene name synonym)|uniprotkb:New component of the BRCA1-A complex(gene name synonym)|uniprotkb:MERIT40(gene name synonym) psi-mi:b5md87_human(display_long)|uniprotkb:PYCR3(gene name)|psi-mi:PYCR3(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514464|imex:IM-12079-91 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001028721.1|refseq:NP_054892.2|ensembl:ENSG00000105393(gene)|ensembl:ENST00000359435(transcript)|ensembl:ENST00000598188(transcript)|ensembl:ENST00000601043(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006325"(chromatin organization)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016604"(nuclear body)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0051301"(cell division)|go:"GO:0070531"(BRCA1-A complex)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0070552"(BRISC complex)|interpro:IPR026126|interpro:IPR036465|mint:Q9NWV8|rcsb pdb:6H3C|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473|refseq:NP_001275685.1|refseq:NP_001275686.1 ensembl:ENSG00000104524(gene)|ensembl:ENST00000377579(transcript)|ensembl:ENST00000634183(transcript)|go:"GO:0004735"(pyrroline-5-carboxylate reductase activity)|go:"GO:0055129"(L-proline biosynthetic process)|interpro:IPR000304(Delta 1-pyrroline-5-carboxylate reductase)|interpro:IPR008927(6-phosphogluconate dehydrogenase, C-terminal-like)|interpro:IPR029036|ensembl:ENSG00000276657(gene) psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:o71OvjzuL/7w4247ap7fm6i3pXU9606 rogid:gFsOHYTyQNZ93BJH1JNXD5bpX609606 intact-crc:2F9E49C582BB9C1C|rigid:trNYDYqpT7OPgee2YiBJgfHUhqw false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9NWV8 uniprotkb:Q8NBU5 intact:EBI-745725|uniprotkb:Q6FIA0|uniprotkb:Q9P018|uniprotkb:A8MQT0|uniprotkb:B4DRY9|uniprotkb:B4DVR1|ensembl:ENSP00000352408|ensembl:ENSP00000470920|ensembl:ENSP00000471605 intact:EBI-2511886|ensembl:ENSP00000339016|ensembl:ENSP00000339017|ensembl:ENSP00000489353|ensembl:ENSP00000489455|ensembl:ENSP00000506333|uniprotkb:Q6P4B9|uniprotkb:Q969Y3|uniprotkb:Q8WYR9|uniprotkb:Q8N3G1|uniprotkb:Q6DKG1|uniprotkb:D3DR26 psi-mi:baba1_human(display_long)|uniprotkb:BABAM1(gene name)|psi-mi:BABAM1(display_short)|uniprotkb:HSPC142(orf name)|uniprotkb:C19orf62(gene name synonym)|uniprotkb:NBA1(gene name synonym)|uniprotkb:Mediator of RAP80 interactions and targeting subunit of 40 kDa(gene name synonym)|uniprotkb:New component of the BRCA1-A complex(gene name synonym)|uniprotkb:MERIT40(gene name synonym) psi-mi:atad1_human(display_long)|uniprotkb:ATAD1(gene name)|psi-mi:ATAD1(display_short)|uniprotkb:Thorase(gene name synonym)|uniprotkb:FNP001(orf name)|uniprotkb:ATPase family AAA domain-containing protein 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514464|imex:IM-12079-91 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001028721.1|refseq:NP_054892.2|ensembl:ENSG00000105393(gene)|ensembl:ENST00000359435(transcript)|ensembl:ENST00000598188(transcript)|ensembl:ENST00000601043(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006325"(chromatin organization)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016604"(nuclear body)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0051301"(cell division)|go:"GO:0070531"(BRCA1-A complex)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0070552"(BRISC complex)|interpro:IPR026126|interpro:IPR036465|mint:Q9NWV8|rcsb pdb:6H3C|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473|refseq:NP_001275685.1|refseq:NP_001275686.1 ensembl:ENSG00000138138(gene)|ensembl:ENSG00000283024(gene)|ensembl:ENST00000308448(transcript)|ensembl:ENST00000328142(transcript)|ensembl:ENST00000634773(transcript)|ensembl:ENST00000634970(transcript)|ensembl:ENST00000680024(transcript)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0005524"(ATP binding)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0051967"(negative regulation of synaptic transmission, glutamatergic)|go:"GO:0140567"(transmembrane protein dislocase activity)|go:"GO:0140570"(extraction of mislocalized protein from mitochondrial outer membrane)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR027417|interpro:IPR041569|reactome:R-HSA-9603798|refseq:NP_116199.2|refseq:NP_001308896.1|refseq:XP_005270309.1|refseq:XP_016872336.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:o71OvjzuL/7w4247ap7fm6i3pXU9606 rogid:IGkIH4udjuFoshP9hMDDK0ARNOg9606 intact-crc:2F9E49C582BB9C1C|rigid:trNYDYqpT7OPgee2YiBJgfHUhqw false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9NWV8 uniprotkb:Q8N1G4 intact:EBI-745725|uniprotkb:Q6FIA0|uniprotkb:Q9P018|uniprotkb:A8MQT0|uniprotkb:B4DRY9|uniprotkb:B4DVR1|ensembl:ENSP00000352408|ensembl:ENSP00000470920|ensembl:ENSP00000471605 intact:EBI-2509921|ensembl:ENSP00000367498|uniprotkb:Q9ULN5 psi-mi:baba1_human(display_long)|uniprotkb:BABAM1(gene name)|psi-mi:BABAM1(display_short)|uniprotkb:HSPC142(orf name)|uniprotkb:C19orf62(gene name synonym)|uniprotkb:NBA1(gene name synonym)|uniprotkb:Mediator of RAP80 interactions and targeting subunit of 40 kDa(gene name synonym)|uniprotkb:New component of the BRCA1-A complex(gene name synonym)|uniprotkb:MERIT40(gene name synonym) psi-mi:lrc47_human(display_long)|uniprotkb:LRRC47(gene name)|psi-mi:LRRC47(display_short)|uniprotkb:KIAA1185(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514464|imex:IM-12079-91 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001028721.1|refseq:NP_054892.2|ensembl:ENSG00000105393(gene)|ensembl:ENST00000359435(transcript)|ensembl:ENST00000598188(transcript)|ensembl:ENST00000601043(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006325"(chromatin organization)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016604"(nuclear body)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0051301"(cell division)|go:"GO:0070531"(BRCA1-A complex)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0070552"(BRISC complex)|interpro:IPR026126|interpro:IPR036465|mint:Q9NWV8|rcsb pdb:6H3C|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473|refseq:NP_001275685.1|refseq:NP_001275686.1 ensembl:ENSG00000130764(gene)|ensembl:ENST00000378251(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004826"(phenylalanine-tRNA ligase activity)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR005146(B3/B4 tRNA-binding domain)|interpro:IPR020825|interpro:IPR025875|interpro:IPR032675|rcsb pdb:6ZXD|rcsb pdb:6ZXE|rcsb pdb:6ZXF|rcsb pdb:6ZXG|refseq:NP_065761.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:o71OvjzuL/7w4247ap7fm6i3pXU9606 rogid:aPzU//EIwK8J4it97jCw/YyKFWU9606 intact-crc:2F9E49C582BB9C1C|rigid:trNYDYqpT7OPgee2YiBJgfHUhqw false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9NWV8 uniprotkb:P46459 intact:EBI-745725|uniprotkb:Q6FIA0|uniprotkb:Q9P018|uniprotkb:A8MQT0|uniprotkb:B4DRY9|uniprotkb:B4DVR1|ensembl:ENSP00000352408|ensembl:ENSP00000470920|ensembl:ENSP00000471605 intact:EBI-712251|ensembl:ENSP00000381293|ensembl:ENSP00000478614|ensembl:ENSP00000481714|uniprotkb:Q8N6D7|uniprotkb:Q9UKZ2|uniprotkb:A8K2D9|uniprotkb:B4DFA2 psi-mi:baba1_human(display_long)|uniprotkb:BABAM1(gene name)|psi-mi:BABAM1(display_short)|uniprotkb:HSPC142(orf name)|uniprotkb:C19orf62(gene name synonym)|uniprotkb:NBA1(gene name synonym)|uniprotkb:Mediator of RAP80 interactions and targeting subunit of 40 kDa(gene name synonym)|uniprotkb:New component of the BRCA1-A complex(gene name synonym)|uniprotkb:MERIT40(gene name synonym) psi-mi:nsf_human(display_long)|uniprotkb:N-ethylmaleimide-sensitive fusion protein(gene name synonym)|uniprotkb:Vesicular-fusion protein NSF(gene name synonym)|uniprotkb:NSF(gene name)|psi-mi:NSF(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514464|imex:IM-12079-91 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001028721.1|refseq:NP_054892.2|ensembl:ENSG00000105393(gene)|ensembl:ENST00000359435(transcript)|ensembl:ENST00000598188(transcript)|ensembl:ENST00000601043(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006325"(chromatin organization)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016604"(nuclear body)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0051301"(cell division)|go:"GO:0070531"(BRCA1-A complex)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0070552"(BRISC complex)|interpro:IPR026126|interpro:IPR036465|mint:Q9NWV8|rcsb pdb:6H3C|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473|refseq:NP_001275685.1|refseq:NP_001275686.1 ensembl:ENSG00000073969(gene)|ensembl:ENSG00000276262(gene)|ensembl:ENSG00000278174(gene)|ensembl:ENST00000398238(transcript)|ensembl:ENST00000611398(transcript)|ensembl:ENST00000620290(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0005524"(ATP binding)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005795"(Golgi stack)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006887"(exocytosis)|go:"GO:0006891"(intra-Golgi vesicle-mediated transport)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035494"(SNARE complex disassembly)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0043198"(dendritic shaft)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045026"(plasma membrane fusion)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0048211"(Golgi vesicle docking)|go:"GO:0140545"(protein disaggregase activity)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR003338(AAA ATPase VAT, N-terminal)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR004201(Cell division protein 48, CDC48, domain 2)|interpro:IPR009010(Aspartate decarboxylase-like fold)|interpro:IPR027417|interpro:IPR029067|interpro:IPR039812|interpro:IPR041569|mint:P46459|rcsb pdb:6KZQ|reactome:R-HSA-204005|reactome:R-HSA-416993|reactome:R-HSA-6807878|reactome:R-HSA-6811434|reactome:R-HSA-6811438|reactome:R-HSA-6811440|refseq:NP_006169.2 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:o71OvjzuL/7w4247ap7fm6i3pXU9606 rogid:J5hsoA0RTiQkWrV7nWpnK8Dvxxg9606 intact-crc:2F9E49C582BB9C1C|rigid:trNYDYqpT7OPgee2YiBJgfHUhqw false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9NWV8 uniprotkb:Q9NXR7 intact:EBI-745725|uniprotkb:Q6FIA0|uniprotkb:Q9P018|uniprotkb:A8MQT0|uniprotkb:B4DRY9|uniprotkb:B4DVR1|ensembl:ENSP00000352408|ensembl:ENSP00000470920|ensembl:ENSP00000471605 intact:EBI-949389|ensembl:ENSP00000339371|ensembl:ENSP00000368945|uniprotkb:Q13880|uniprotkb:Q96P06|uniprotkb:A8K4X1|uniprotkb:Q4ZFX8|uniprotkb:Q53SD0|uniprotkb:Q969X9|uniprotkb:D6W562|uniprotkb:D6W563 psi-mi:baba1_human(display_long)|uniprotkb:BABAM1(gene name)|psi-mi:BABAM1(display_short)|uniprotkb:HSPC142(orf name)|uniprotkb:C19orf62(gene name synonym)|uniprotkb:NBA1(gene name synonym)|uniprotkb:Mediator of RAP80 interactions and targeting subunit of 40 kDa(gene name synonym)|uniprotkb:New component of the BRCA1-A complex(gene name synonym)|uniprotkb:MERIT40(gene name synonym) psi-mi:baba2_human(display_long)|uniprotkb:BABAM2(gene name)|psi-mi:BABAM2(display_short)|uniprotkb:BRCA1-A complex subunit BRE(gene name synonym)|uniprotkb:BRCA1/BRCA2-containing complex subunit 45(gene name synonym)|uniprotkb:BRCC45(gene name synonym)|uniprotkb:BRE(gene name synonym)|uniprotkb:Brain and reproductive organ-expressed protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514464|imex:IM-12079-91 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001028721.1|refseq:NP_054892.2|ensembl:ENSG00000105393(gene)|ensembl:ENST00000359435(transcript)|ensembl:ENST00000598188(transcript)|ensembl:ENST00000601043(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006325"(chromatin organization)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016604"(nuclear body)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0051301"(cell division)|go:"GO:0070531"(BRCA1-A complex)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0070552"(BRISC complex)|interpro:IPR026126|interpro:IPR036465|mint:Q9NWV8|rcsb pdb:6H3C|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473|refseq:NP_001275685.1|refseq:NP_001275686.1 ensembl:ENSG00000158019(gene)|ensembl:ENST00000342045(transcript)|ensembl:ENST00000379624(transcript)|go:"GO:0000152"(nuclear ubiquitin ligase complex)|go:"GO:0000268"(peroxisome targeting sequence binding)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0007165"(signal transduction)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0051301"(cell division)|go:"GO:0070531"(BRCA1-A complex)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0070552"(BRISC complex)|interpro:IPR010358(Brain and reproductive organ-expressed)|rcsb pdb:6H3C|rcsb pdb:6R8F|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473|go:"GO:0006302"(double-strand break repair)|refseq:NP_004890.2|refseq:NP_954661.1|refseq:NP_954662.1|refseq:NP_954663.1|refseq:NP_954664.1|refseq:NP_001248769.1|refseq:NP_001316041.1|refseq:NP_001316042.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:o71OvjzuL/7w4247ap7fm6i3pXU9606 rogid:ULbrw0O7e5M0Hzho3d05OlUnEGM9606 intact-crc:2F9E49C582BB9C1C|rigid:trNYDYqpT7OPgee2YiBJgfHUhqw false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9NWV8 uniprotkb:O00148 intact:EBI-745725|uniprotkb:Q6FIA0|uniprotkb:Q9P018|uniprotkb:A8MQT0|uniprotkb:B4DRY9|uniprotkb:B4DVR1|ensembl:ENSP00000352408|ensembl:ENSP00000470920|ensembl:ENSP00000471605 intact:EBI-348253|ensembl:ENSP00000242776|uniprotkb:Q9BVP6|uniprotkb:Q9H5W0|intact:EBI-2514455|uniprotkb:Q8N5M0|uniprotkb:B1Q2N1 psi-mi:baba1_human(display_long)|uniprotkb:BABAM1(gene name)|psi-mi:BABAM1(display_short)|uniprotkb:HSPC142(orf name)|uniprotkb:C19orf62(gene name synonym)|uniprotkb:NBA1(gene name synonym)|uniprotkb:Mediator of RAP80 interactions and targeting subunit of 40 kDa(gene name synonym)|uniprotkb:New component of the BRCA1-A complex(gene name synonym)|uniprotkb:MERIT40(gene name synonym) psi-mi:dx39a_human(display_long)|uniprotkb:DEAD box protein 39(gene name synonym)|uniprotkb:Nuclear RNA helicase URH49(gene name synonym)|uniprotkb:DDX39A(gene name)|psi-mi:DDX39A(display_short)|uniprotkb:DDX39(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514464|imex:IM-12079-91 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001028721.1|refseq:NP_054892.2|ensembl:ENSG00000105393(gene)|ensembl:ENST00000359435(transcript)|ensembl:ENST00000598188(transcript)|ensembl:ENST00000601043(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006325"(chromatin organization)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016604"(nuclear body)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0051301"(cell division)|go:"GO:0070531"(BRCA1-A complex)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0070552"(BRISC complex)|interpro:IPR026126|interpro:IPR036465|mint:Q9NWV8|rcsb pdb:6H3C|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473|refseq:NP_001275685.1|refseq:NP_001275686.1 ensembl:ENSG00000123136(gene)|ensembl:ENST00000242776(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006405"(RNA export from nucleus)|go:"GO:0006406"(mRNA export from nucleus)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|mint:O00148|reactome:R-HSA-159236|reactome:R-HSA-72187|reactome:R-HSA-73856|go:"GO:0042802"(identical protein binding)|refseq:NP_005795.2|refseq:XP_011525922.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:o71OvjzuL/7w4247ap7fm6i3pXU9606 rogid:EOc5EPfkNVMrdfd9Xx/snoOfhas9606 intact-crc:2F9E49C582BB9C1C|rigid:trNYDYqpT7OPgee2YiBJgfHUhqw false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9NWV8 uniprotkb:Q04323 intact:EBI-745725|uniprotkb:Q6FIA0|uniprotkb:Q9P018|uniprotkb:A8MQT0|uniprotkb:B4DRY9|uniprotkb:B4DVR1|ensembl:ENSP00000352408|ensembl:ENSP00000470920|ensembl:ENSP00000471605 intact:EBI-1058647|ensembl:ENSP00000303991|uniprotkb:Q9BV93|uniprotkb:Q9BVV5|intact:EBI-1993649 psi-mi:baba1_human(display_long)|uniprotkb:BABAM1(gene name)|psi-mi:BABAM1(display_short)|uniprotkb:HSPC142(orf name)|uniprotkb:C19orf62(gene name synonym)|uniprotkb:NBA1(gene name synonym)|uniprotkb:Mediator of RAP80 interactions and targeting subunit of 40 kDa(gene name synonym)|uniprotkb:New component of the BRCA1-A complex(gene name synonym)|uniprotkb:MERIT40(gene name synonym) psi-mi:ubxn1_human(display_long)|uniprotkb:UBXN1(gene name)|psi-mi:UBXN1(display_short)|uniprotkb:SAKS1(gene name synonym)|uniprotkb:SAPK substrate protein 1(gene name synonym)|uniprotkb:UBA/UBX 33.3 kDa protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514464|imex:IM-12079-91 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001028721.1|refseq:NP_054892.2|ensembl:ENSG00000105393(gene)|ensembl:ENST00000359435(transcript)|ensembl:ENST00000598188(transcript)|ensembl:ENST00000601043(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006325"(chromatin organization)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016604"(nuclear body)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0051301"(cell division)|go:"GO:0070531"(BRCA1-A complex)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0070552"(BRISC complex)|interpro:IPR026126|interpro:IPR036465|mint:Q9NWV8|rcsb pdb:6H3C|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473|refseq:NP_001275685.1|refseq:NP_001275686.1 ensembl:ENSG00000162191(gene)|ensembl:ENST00000301935(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0030425"(dendrite)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034098"(VCP-NPL4-UFD1 AAA ATPase complex)|go:"GO:0036435"(K48-linked polyubiquitin modification-dependent protein binding)|refseq:NP_001273006.1|refseq:NP_001273007.1|refseq:NP_056937.2|go:"GO:0043025"(neuronal cell body)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0051117"(ATPase binding)|go:"GO:0071796"(K6-linked polyubiquitin modification-dependent protein binding)|go:"GO:1903094"(negative regulation of protein K48-linked deubiquitination)|go:"GO:1904293"(negative regulation of ERAD pathway)|go:"GO:1904855"(proteasome regulatory particle binding)|go:"GO:2000157"(negative regulation of ubiquitin-specific protease activity)|interpro:IPR001012(UBX)|interpro:IPR009060(UBA-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR029071|interpro:IPR041923|reactome:R-HSA-532668|reactome:R-HSA-5693565|go:"GO:0043130"(ubiquitin binding)|refseq:XP_005274090.1|refseq:XP_016873363.1|dip:DIP-29467N psi-mi:"MI:0469"(intact) - crc64:E4E0C8BBAC93F2BB figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:o71OvjzuL/7w4247ap7fm6i3pXU9606 rogid:KdHMRM9FSd6VT6MvJTxzdjARlRw9606 intact-crc:2F9E49C582BB9C1C|rigid:trNYDYqpT7OPgee2YiBJgfHUhqw false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9NWV8 uniprotkb:P38405 intact:EBI-745725|uniprotkb:Q6FIA0|uniprotkb:Q9P018|uniprotkb:A8MQT0|uniprotkb:B4DRY9|uniprotkb:B4DVR1|ensembl:ENSP00000352408|ensembl:ENSP00000470920|ensembl:ENSP00000471605 intact:EBI-2512639|ensembl:ENSP00000269162|ensembl:ENSP00000408489|ensembl:ENSP00000439023|uniprotkb:Q86XU3|uniprotkb:B7ZA26 psi-mi:baba1_human(display_long)|uniprotkb:BABAM1(gene name)|psi-mi:BABAM1(display_short)|uniprotkb:HSPC142(orf name)|uniprotkb:C19orf62(gene name synonym)|uniprotkb:NBA1(gene name synonym)|uniprotkb:Mediator of RAP80 interactions and targeting subunit of 40 kDa(gene name synonym)|uniprotkb:New component of the BRCA1-A complex(gene name synonym)|uniprotkb:MERIT40(gene name synonym) psi-mi:gnal_human(display_long)|uniprotkb:GNAL(gene name)|psi-mi:GNAL(display_short)|uniprotkb:Adenylate cyclase-stimulating G alpha protein, olfactory type(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514464|imex:IM-12079-91 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001028721.1|refseq:NP_054892.2|ensembl:ENSG00000105393(gene)|ensembl:ENST00000359435(transcript)|ensembl:ENST00000598188(transcript)|ensembl:ENST00000601043(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006325"(chromatin organization)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016604"(nuclear body)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0051301"(cell division)|go:"GO:0070531"(BRCA1-A complex)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0070552"(BRISC complex)|interpro:IPR026126|interpro:IPR036465|mint:Q9NWV8|rcsb pdb:6H3C|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473|refseq:NP_001275685.1|refseq:NP_001275686.1 ensembl:ENSG00000141404(gene)|ensembl:ENST00000269162(transcript)|ensembl:ENST00000423027(transcript)|ensembl:ENST00000535121(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007191"(adenylate cyclase-activating dopamine receptor signaling pathway)|go:"GO:0007606"(sensory perception of chemical stimulus)|go:"GO:0031683"(G-protein beta/gamma-subunit complex binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000367(G-protein alpha subunit, group S)|interpro:IPR001019("Guanine nucleotide binding protein (G-protein), alpha subunit")|interpro:IPR011025(G protein alpha subunit, helical insertion)|interpro:IPR027417|reactome:R-HSA-170660|reactome:R-HSA-170670|reactome:R-HSA-381753|refseq:NP_001135811.1|refseq:NP_892023.1|refseq:NP_001248372.1|refseq:NP_001248373.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:o71OvjzuL/7w4247ap7fm6i3pXU9606 rogid:IC+CI3TYQdbioxaPBNu/cSGn7TQ9606 intact-crc:2F9E49C582BB9C1C|rigid:trNYDYqpT7OPgee2YiBJgfHUhqw false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9NWV8 uniprotkb:P49915 intact:EBI-745725|uniprotkb:Q6FIA0|uniprotkb:Q9P018|uniprotkb:A8MQT0|uniprotkb:B4DRY9|uniprotkb:B4DVR1|ensembl:ENSP00000352408|ensembl:ENSP00000470920|ensembl:ENSP00000471605 intact:EBI-1050289|uniprotkb:A8K639|uniprotkb:B4DXV7|uniprotkb:F8W720|ensembl:ENSP00000419851 psi-mi:baba1_human(display_long)|uniprotkb:BABAM1(gene name)|psi-mi:BABAM1(display_short)|uniprotkb:HSPC142(orf name)|uniprotkb:C19orf62(gene name synonym)|uniprotkb:NBA1(gene name synonym)|uniprotkb:Mediator of RAP80 interactions and targeting subunit of 40 kDa(gene name synonym)|uniprotkb:New component of the BRCA1-A complex(gene name synonym)|uniprotkb:MERIT40(gene name synonym) psi-mi:guaa_human(display_long)|uniprotkb:GMP synthetase(gene name synonym)|uniprotkb:Glutamine amidotransferase(gene name synonym)|uniprotkb:GMPS(gene name)|psi-mi:GMPS(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514464|imex:IM-12079-91 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001028721.1|refseq:NP_054892.2|ensembl:ENSG00000105393(gene)|ensembl:ENST00000359435(transcript)|ensembl:ENST00000598188(transcript)|ensembl:ENST00000601043(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006325"(chromatin organization)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016604"(nuclear body)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0051301"(cell division)|go:"GO:0070531"(BRCA1-A complex)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0070552"(BRISC complex)|interpro:IPR026126|interpro:IPR036465|mint:Q9NWV8|rcsb pdb:6H3C|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473|refseq:NP_001275685.1|refseq:NP_001275686.1 refseq:NP_003866.1|ensembl:ENSG00000163655(gene)|ensembl:ENST00000496455(transcript)|go:"GO:0003921"(GMP synthase activity)|go:"GO:0003922"("GMP synthase (glutamine-hydrolyzing) activity")|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006177"(GMP biosynthetic process)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0009113"(purine nucleobase biosynthetic process)|go:"GO:0009168"(purine ribonucleoside monophosphate biosynthetic process)|go:"GO:0016462"(pyrophosphatase activity)|interpro:IPR001674(GMP synthase, C-terminal)|interpro:IPR004739(GMP synthase, N-terminal)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR017926|interpro:IPR022310|interpro:IPR025777|interpro:IPR029062|mint:P49915|rcsb pdb:2VPI|rcsb pdb:2VXO|reactome:R-HSA-73817 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:o71OvjzuL/7w4247ap7fm6i3pXU9606 rogid:LYs65bPoqjVG/ZxA6v+yJo3HsLI9606 intact-crc:2F9E49C582BB9C1C|rigid:trNYDYqpT7OPgee2YiBJgfHUhqw false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9NWV8 uniprotkb:P18085 intact:EBI-745725|uniprotkb:Q6FIA0|uniprotkb:Q9P018|uniprotkb:A8MQT0|uniprotkb:B4DRY9|uniprotkb:B4DVR1|ensembl:ENSP00000352408|ensembl:ENSP00000470920|ensembl:ENSP00000471605 intact:EBI-1237085|ensembl:ENSP00000306010|uniprotkb:P21371|uniprotkb:B2R7J7 psi-mi:baba1_human(display_long)|uniprotkb:BABAM1(gene name)|psi-mi:BABAM1(display_short)|uniprotkb:HSPC142(orf name)|uniprotkb:C19orf62(gene name synonym)|uniprotkb:NBA1(gene name synonym)|uniprotkb:Mediator of RAP80 interactions and targeting subunit of 40 kDa(gene name synonym)|uniprotkb:New component of the BRCA1-A complex(gene name synonym)|uniprotkb:MERIT40(gene name synonym) psi-mi:arf4_human(display_long)|uniprotkb:ARF4(gene name)|psi-mi:ARF4(display_short)|uniprotkb:ARF2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514464|imex:IM-12079-91 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001028721.1|refseq:NP_054892.2|ensembl:ENSG00000105393(gene)|ensembl:ENST00000359435(transcript)|ensembl:ENST00000598188(transcript)|ensembl:ENST00000601043(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006325"(chromatin organization)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016604"(nuclear body)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0051301"(cell division)|go:"GO:0070531"(BRCA1-A complex)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0070552"(BRISC complex)|interpro:IPR026126|interpro:IPR036465|mint:Q9NWV8|rcsb pdb:6H3C|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473|refseq:NP_001275685.1|refseq:NP_001275686.1 ensembl:ENSG00000168374(gene)|ensembl:ENST00000303436(transcript)|refseq:NP_001651.1|dip:DIP-38214N|go:"GO:0003924"(GTPase activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007420"(brain development)|go:"GO:0007612"(learning)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016477"(cell migration)|go:"GO:0031584"(activation of phospholipase D activity)|go:"GO:0032587"(ruffle membrane)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0045176"(apical protein localization)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048678"(response to axon injury)|go:"GO:0060271"(cilium assembly)|go:"GO:0060996"(dendritic spine development)|go:"GO:0061512"(protein localization to cilium)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099175"(regulation of postsynapse organization)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR006689(ARF/SAR superfamily)|interpro:IPR027417|mint:P18085|rcsb pdb:1Z6X|reactome:R-HSA-5620916|reactome:R-HSA-6807878|reactome:R-HSA-6811434 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:o71OvjzuL/7w4247ap7fm6i3pXU9606 rogid:AN3aBuSStAMrmkqq1HEDQtOiCy49606 intact-crc:2F9E49C582BB9C1C|rigid:trNYDYqpT7OPgee2YiBJgfHUhqw false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9NWV8 uniprotkb:Q9BPX6 intact:EBI-745725|uniprotkb:Q6FIA0|uniprotkb:Q9P018|uniprotkb:A8MQT0|uniprotkb:B4DRY9|uniprotkb:B4DVR1|ensembl:ENSP00000352408|ensembl:ENSP00000470920|ensembl:ENSP00000471605 intact:EBI-2371996|uniprotkb:O75785|uniprotkb:Q9H9N6|uniprotkb:Q9UFX0|uniprotkb:A8MV96|uniprotkb:B3KN20|uniprotkb:B4DJH9|uniprotkb:B4DPI1|uniprotkb:B5MBY3|uniprotkb:D3YTJ3|ensembl:ENSP00000354415 psi-mi:baba1_human(display_long)|uniprotkb:BABAM1(gene name)|psi-mi:BABAM1(display_short)|uniprotkb:HSPC142(orf name)|uniprotkb:C19orf62(gene name synonym)|uniprotkb:NBA1(gene name synonym)|uniprotkb:Mediator of RAP80 interactions and targeting subunit of 40 kDa(gene name synonym)|uniprotkb:New component of the BRCA1-A complex(gene name synonym)|uniprotkb:MERIT40(gene name synonym) psi-mi:micu1_human(display_long)|uniprotkb:MICU1(gene name)|psi-mi:MICU1(display_short)|uniprotkb:Calcium-binding atopy-related autoantigen 1(gene name synonym)|uniprotkb:CBARA1(gene name synonym)|uniprotkb:CALC(gene name synonym)|uniprotkb:Atopy-related autoantigen CALC(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514464|imex:IM-12079-91 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001028721.1|refseq:NP_054892.2|ensembl:ENSG00000105393(gene)|ensembl:ENST00000359435(transcript)|ensembl:ENST00000598188(transcript)|ensembl:ENST00000601043(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006325"(chromatin organization)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016604"(nuclear body)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0051301"(cell division)|go:"GO:0070531"(BRCA1-A complex)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0070552"(BRISC complex)|interpro:IPR026126|interpro:IPR036465|mint:Q9NWV8|rcsb pdb:6H3C|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473|refseq:NP_001275685.1|refseq:NP_001275686.1 refseq:NP_001182447.1|refseq:NP_001182448.1|refseq:NP_006068.2|dip:DIP-53438N|ensembl:ENSG00000107745(gene)|ensembl:ENST00000361114(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005622"(intracellular anatomical structure)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0006851"(mitochondrial calcium ion transmembrane transport)|go:"GO:0006952"(defense response)|go:"GO:0032592"(integral component of mitochondrial membrane)|go:"GO:0034704"(calcium channel complex)|go:"GO:0036444"(calcium import into the mitochondrion)|go:"GO:0042802"(identical protein binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0051560"(mitochondrial calcium ion homeostasis)|go:"GO:0051561"(positive regulation of mitochondrial calcium ion concentration)|go:"GO:0070509"(calcium ion import)|go:"GO:1900069"(regulation of cellular hyperosmotic salinity response)|go:"GO:1990246"(uniplex complex)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR039800|rcsb pdb:4NSC|rcsb pdb:4NSD|rcsb pdb:6K7Y|rcsb pdb:6LB7|rcsb pdb:6LB8|rcsb pdb:6LE5|rcsb pdb:6WDN|rcsb pdb:6WDO|rcsb pdb:6XJX|rcsb pdb:6XQN|rcsb pdb:6XQO|reactome:R-HSA-8949215|reactome:R-HSA-8949664|rcsb pdb:6XJV psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:o71OvjzuL/7w4247ap7fm6i3pXU9606 rogid:ieoktRyh6dR8RvLctKOhbT84qPU9606 intact-crc:2F9E49C582BB9C1C|rigid:trNYDYqpT7OPgee2YiBJgfHUhqw false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9NWV8 uniprotkb:O95271 intact:EBI-745725|uniprotkb:Q6FIA0|uniprotkb:Q9P018|uniprotkb:A8MQT0|uniprotkb:B4DRY9|uniprotkb:B4DVR1|ensembl:ENSP00000352408|ensembl:ENSP00000470920|ensembl:ENSP00000471605 intact:EBI-1105254|uniprotkb:O95272|uniprotkb:Q4G0F2|intact:EBI-28985643|ensembl:ENSP00000311579 psi-mi:baba1_human(display_long)|uniprotkb:BABAM1(gene name)|psi-mi:BABAM1(display_short)|uniprotkb:HSPC142(orf name)|uniprotkb:C19orf62(gene name synonym)|uniprotkb:NBA1(gene name synonym)|uniprotkb:Mediator of RAP80 interactions and targeting subunit of 40 kDa(gene name synonym)|uniprotkb:New component of the BRCA1-A complex(gene name synonym)|uniprotkb:MERIT40(gene name synonym) psi-mi:tnks1_human(display_long)|uniprotkb:TNKS(gene name)|psi-mi:TNKS(display_short)|uniprotkb:PARP5A(gene name synonym)|uniprotkb:PARPL(gene name synonym)|uniprotkb:TIN1(gene name synonym)|uniprotkb:TINF1(gene name synonym)|uniprotkb:TNKS1(gene name synonym)|uniprotkb:Tankyrase I(gene name synonym)|uniprotkb:TNKS-1(gene name synonym)|uniprotkb:TRF1-interacting ankyrin-related ADP-ribose polymerase(gene name synonym)|uniprotkb:Poly [ADP-ribose] polymerase 5A(gene name synonym)|uniprotkb:ADP-ribosyltransferase diphtheria toxin-like 5(gene name synonym)|uniprotkb:Protein poly-ADP-ribosyltransferase tankyrase-1(gene name synonym)|uniprotkb:Tankyrase-1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514464|imex:IM-12079-91 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001028721.1|refseq:NP_054892.2|ensembl:ENSG00000105393(gene)|ensembl:ENST00000359435(transcript)|ensembl:ENST00000598188(transcript)|ensembl:ENST00000601043(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006325"(chromatin organization)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016604"(nuclear body)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0051301"(cell division)|go:"GO:0070531"(BRCA1-A complex)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0070552"(BRISC complex)|interpro:IPR026126|interpro:IPR036465|mint:Q9NWV8|rcsb pdb:6H3C|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473|refseq:NP_001275685.1|refseq:NP_001275686.1 refseq:NP_003738.2|rcsb pdb:5JHQ|rcsb pdb:5JTI|rcsb pdb:5JU5|rcsb pdb:5KNI|rcsb pdb:6QXU|rcsb pdb:6URQ|reactome:R-HSA-201681|reactome:R-HSA-4641257|reactome:R-HSA-5545619|reactome:R-HSA-5689880|reactome:R-HSA-8948751|rcsb pdb:5GP7|ensembl:ENSP00000311579|ensembl:ENSG00000173273(gene)|ensembl:ENST00000310430(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000242"(pericentriolar material)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015031"(protein transport)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0031670"(cellular response to nutrient)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032210"(regulation of telomere maintenance via telomerase)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0042393"(histone binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051028"(mRNA transport)|go:"GO:0051225"(spindle assembly)|go:"GO:0051301"(cell division)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0070198"(protein localization to chromosome, telomeric region)|go:"GO:0070212"(protein poly-ADP-ribosylation)|go:"GO:0070213"(protein auto-ADP-ribosylation)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:1904357"(negative regulation of telomere maintenance via telomere lengthening)|go:"GO:1904743"(negative regulation of telomeric DNA binding)|go:"GO:1904908"(negative regulation of maintenance of mitotic sister chromatid cohesion, telomeric)|go:"GO:1990404"(protein ADP-ribosylase activity)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR012317("Poly(ADP-ribose) polymerase, catalytic region")|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR028731|interpro:IPR036770|mint:O95271|rcsb pdb:2RF5|rcsb pdb:3UDD|rcsb pdb:3UH2|rcsb pdb:3UH4|rcsb pdb:4DVI|rcsb pdb:4I9I|go:"GO:0016055"(Wnt signaling pathway)|rcsb pdb:4K4F|rcsb pdb:4KRS|rcsb pdb:4LI6|rcsb pdb:4LI7|rcsb pdb:4LI8|rcsb pdb:4MSG|rcsb pdb:4MSK|rcsb pdb:4MT9|rcsb pdb:4N3R|rcsb pdb:4N4V|rcsb pdb:4OA7|rcsb pdb:4TOR|rcsb pdb:4TOS|rcsb pdb:4U6A|rcsb pdb:4UUH|rcsb pdb:4UW1|rcsb pdb:4K4E|rcsb pdb:4W5S|rcsb pdb:4W6E|rcsb pdb:5EBT|rcsb pdb:5ECE|rcsb pdb:5ETY|dip:DIP-36652N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:o71OvjzuL/7w4247ap7fm6i3pXU9606 rogid:0WKEfg5OMAISQutoJb2w+hBfmOU9606 intact-crc:2F9E49C582BB9C1C|rigid:trNYDYqpT7OPgee2YiBJgfHUhqw false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9NWV8 uniprotkb:Q9BVG4 intact:EBI-745725|uniprotkb:Q6FIA0|uniprotkb:Q9P018|uniprotkb:A8MQT0|uniprotkb:B4DRY9|uniprotkb:B4DVR1|ensembl:ENSP00000352408|ensembl:ENSP00000470920|ensembl:ENSP00000471605 intact:EBI-722092|ensembl:ENSP00000362456 psi-mi:baba1_human(display_long)|uniprotkb:BABAM1(gene name)|psi-mi:BABAM1(display_short)|uniprotkb:HSPC142(orf name)|uniprotkb:C19orf62(gene name synonym)|uniprotkb:NBA1(gene name synonym)|uniprotkb:Mediator of RAP80 interactions and targeting subunit of 40 kDa(gene name synonym)|uniprotkb:New component of the BRCA1-A complex(gene name synonym)|uniprotkb:MERIT40(gene name synonym) psi-mi:pbdc1_human(display_long)|uniprotkb:PBDC1(gene name)|psi-mi:PBDC1(display_short)|uniprotkb:CXorf26(gene name synonym)|uniprotkb:Polysaccharide biosynthesis domain-containing protein 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514464|imex:IM-12079-91 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001028721.1|refseq:NP_054892.2|ensembl:ENSG00000105393(gene)|ensembl:ENST00000359435(transcript)|ensembl:ENST00000598188(transcript)|ensembl:ENST00000601043(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006325"(chromatin organization)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016604"(nuclear body)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0051301"(cell division)|go:"GO:0070531"(BRCA1-A complex)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0070552"(BRISC complex)|interpro:IPR026126|interpro:IPR036465|mint:Q9NWV8|rcsb pdb:6H3C|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473|refseq:NP_001275685.1|refseq:NP_001275686.1 refseq:NP_057584.2|refseq:NP_001287817.1|ensembl:ENSG00000102390(gene)|ensembl:ENST00000373358(transcript)|interpro:IPR008476(Protein of unknown function DUF757)|interpro:IPR021148|interpro:IPR023139 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:o71OvjzuL/7w4247ap7fm6i3pXU9606 rogid:lrAfLlNkRrXqqWWD7kyAokBG9ck9606 intact-crc:2F9E49C582BB9C1C|rigid:trNYDYqpT7OPgee2YiBJgfHUhqw false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9NWV8 uniprotkb:Q16718 intact:EBI-745725|uniprotkb:Q6FIA0|uniprotkb:Q9P018|uniprotkb:A8MQT0|uniprotkb:B4DRY9|uniprotkb:B4DVR1|ensembl:ENSP00000352408|ensembl:ENSP00000470920|ensembl:ENSP00000471605 intact:EBI-746417|uniprotkb:Q6IRX7|uniprotkb:Q5H9R2|uniprotkb:B2RD98|ensembl:ENSP00000347988 psi-mi:baba1_human(display_long)|uniprotkb:BABAM1(gene name)|psi-mi:BABAM1(display_short)|uniprotkb:HSPC142(orf name)|uniprotkb:C19orf62(gene name synonym)|uniprotkb:NBA1(gene name synonym)|uniprotkb:Mediator of RAP80 interactions and targeting subunit of 40 kDa(gene name synonym)|uniprotkb:New component of the BRCA1-A complex(gene name synonym)|uniprotkb:MERIT40(gene name synonym) psi-mi:ndua5_human(display_long)|uniprotkb:Complex I subunit B13(gene name synonym)|uniprotkb:NADH-ubiquinone oxidoreductase 13 kDa-B subunit(gene name synonym)|uniprotkb:Complex I-13kD-B(gene name synonym)|uniprotkb:NDUFA5(gene name)|psi-mi:NDUFA5(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514464|imex:IM-12079-91 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001028721.1|refseq:NP_054892.2|ensembl:ENSG00000105393(gene)|ensembl:ENST00000359435(transcript)|ensembl:ENST00000598188(transcript)|ensembl:ENST00000601043(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006325"(chromatin organization)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016604"(nuclear body)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0051301"(cell division)|go:"GO:0070531"(BRCA1-A complex)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0070552"(BRISC complex)|interpro:IPR026126|interpro:IPR036465|mint:Q9NWV8|rcsb pdb:6H3C|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473|refseq:NP_001275685.1|refseq:NP_001275686.1 refseq:NP_004991.1|refseq:NP_001269348.1|refseq:NP_001269350.1|refseq:NP_001269351.1|ensembl:ENSG00000128609(gene)|ensembl:ENST00000355749(transcript)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|interpro:IPR006806(ETC complex I subunit)|mint:Q16718|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198|reactome:R-HSA-9013408|refseq:NP_001269349.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:o71OvjzuL/7w4247ap7fm6i3pXU9606 rogid:t042+V0dLA6z/X1MQdgkt7ya7qs9606 intact-crc:2F9E49C582BB9C1C|rigid:trNYDYqpT7OPgee2YiBJgfHUhqw false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9NWV8 uniprotkb:Q96EL3 intact:EBI-745725|uniprotkb:Q6FIA0|uniprotkb:Q9P018|uniprotkb:A8MQT0|uniprotkb:B4DRY9|uniprotkb:B4DVR1|ensembl:ENSP00000352408|ensembl:ENSP00000470920|ensembl:ENSP00000471605 intact:EBI-2513715|ensembl:ENSP00000258105 psi-mi:baba1_human(display_long)|uniprotkb:BABAM1(gene name)|psi-mi:BABAM1(display_short)|uniprotkb:HSPC142(orf name)|uniprotkb:C19orf62(gene name synonym)|uniprotkb:NBA1(gene name synonym)|uniprotkb:Mediator of RAP80 interactions and targeting subunit of 40 kDa(gene name synonym)|uniprotkb:New component of the BRCA1-A complex(gene name synonym)|uniprotkb:MERIT40(gene name synonym) psi-mi:rm53_human(display_long)|uniprotkb:MRPL53(gene name)|psi-mi:MRPL53(display_short)|uniprotkb:Mitochondrial large ribosomal subunit protein mL53(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514464|imex:IM-12079-91 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001028721.1|refseq:NP_054892.2|ensembl:ENSG00000105393(gene)|ensembl:ENST00000359435(transcript)|ensembl:ENST00000598188(transcript)|ensembl:ENST00000601043(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006325"(chromatin organization)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016604"(nuclear body)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0051301"(cell division)|go:"GO:0070531"(BRCA1-A complex)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0070552"(BRISC complex)|interpro:IPR026126|interpro:IPR036465|mint:Q9NWV8|rcsb pdb:6H3C|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473|refseq:NP_001275685.1|refseq:NP_001275686.1 ensembl:ENSG00000204822(gene)|ensembl:ENST00000258105(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005762"(mitochondrial large ribosomal subunit)|interpro:IPR019716|rcsb pdb:3J7Y|rcsb pdb:3J9M|rcsb pdb:5OOL|rcsb pdb:5OOM|rcsb pdb:6I9R|rcsb pdb:6NU2|rcsb pdb:6NU3|rcsb pdb:6VLZ|rcsb pdb:6VMI|rcsb pdb:6ZM5|rcsb pdb:6ZM6|rcsb pdb:6ZS9|rcsb pdb:6ZSA|rcsb pdb:6ZSB|rcsb pdb:6ZSC|rcsb pdb:6ZSD|rcsb pdb:6ZSE|rcsb pdb:6ZSG|rcsb pdb:7A5F|rcsb pdb:7A5G|rcsb pdb:7A5H|rcsb pdb:7A5I|rcsb pdb:7A5K|rcsb pdb:7L08|rcsb pdb:7L20|rcsb pdb:7O9K|rcsb pdb:7O9M|rcsb pdb:7ODR|rcsb pdb:7ODS|rcsb pdb:7ODT|rcsb pdb:7OF0|rcsb pdb:7OF2|rcsb pdb:7OF3|rcsb pdb:7OF4|rcsb pdb:7OF5|rcsb pdb:7OF6|rcsb pdb:7OF7|rcsb pdb:7OG4|reactome:R-HSA-5368286|reactome:R-HSA-5389840|reactome:R-HSA-5419276|rcsb pdb:7A5J|refseq:NP_444278.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:o71OvjzuL/7w4247ap7fm6i3pXU9606 rogid:+P6xCKwzJVVQv/StyLhlLH9NkgA9606 intact-crc:2F9E49C582BB9C1C|rigid:trNYDYqpT7OPgee2YiBJgfHUhqw false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9NWV8 uniprotkb:Q9GZT3 intact:EBI-745725|uniprotkb:Q6FIA0|uniprotkb:Q9P018|uniprotkb:A8MQT0|uniprotkb:B4DRY9|uniprotkb:B4DVR1|ensembl:ENSP00000352408|ensembl:ENSP00000470920|ensembl:ENSP00000471605 intact:EBI-1050793|uniprotkb:J3KMY7|ensembl:ENSP00000450909|intact:EBI-10967524 psi-mi:baba1_human(display_long)|uniprotkb:BABAM1(gene name)|psi-mi:BABAM1(display_short)|uniprotkb:HSPC142(orf name)|uniprotkb:C19orf62(gene name synonym)|uniprotkb:NBA1(gene name synonym)|uniprotkb:Mediator of RAP80 interactions and targeting subunit of 40 kDa(gene name synonym)|uniprotkb:New component of the BRCA1-A complex(gene name synonym)|uniprotkb:MERIT40(gene name synonym) psi-mi:slirp_human(display_long)|uniprotkb:SLIRP(gene name)|psi-mi:SLIRP(display_short)|uniprotkb:C14orf156(gene name synonym)|uniprotkb:DC23(orf name)|uniprotkb:DC50(orf name)|uniprotkb:PD04872(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514464|imex:IM-12079-91 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001028721.1|refseq:NP_054892.2|ensembl:ENSG00000105393(gene)|ensembl:ENST00000359435(transcript)|ensembl:ENST00000598188(transcript)|ensembl:ENST00000601043(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006325"(chromatin organization)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016604"(nuclear body)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0051301"(cell division)|go:"GO:0070531"(BRCA1-A complex)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0070552"(BRISC complex)|interpro:IPR026126|interpro:IPR036465|mint:Q9NWV8|rcsb pdb:6H3C|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473|refseq:NP_001275685.1|refseq:NP_001275686.1 refseq:NP_112487.1|refseq:NP_001254792.1|refseq:NP_001254793.1|ensembl:ENSG00000119705(gene)|ensembl:ENST00000557342(transcript)|go:"GO:0000961"(negative regulation of mitochondrial RNA catabolic process)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0007286"(spermatid development)|go:"GO:0007338"(single fertilization)|go:"GO:0030317"(flagellated sperm motility)|go:"GO:0036126"(sperm flagellum)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070584"(mitochondrion morphogenesis)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034152|interpro:IPR035979|mint:Q9GZT3 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:o71OvjzuL/7w4247ap7fm6i3pXU9606 rogid:8sPWOtmxPTOVlthXwBiIIp/+6go9606 intact-crc:2F9E49C582BB9C1C|rigid:trNYDYqpT7OPgee2YiBJgfHUhqw false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9NWV8 uniprotkb:P25789 intact:EBI-745725|uniprotkb:Q6FIA0|uniprotkb:Q9P018|uniprotkb:A8MQT0|uniprotkb:B4DRY9|uniprotkb:B4DVR1|ensembl:ENSP00000352408|ensembl:ENSP00000470920|ensembl:ENSP00000471605 intact:EBI-359310|uniprotkb:Q8TBD1|uniprotkb:Q53XP2|ensembl:ENSP00000044462|ensembl:ENSP00000453887|uniprotkb:D3DW86|uniprotkb:Q567Q5 psi-mi:baba1_human(display_long)|uniprotkb:BABAM1(gene name)|psi-mi:BABAM1(display_short)|uniprotkb:HSPC142(orf name)|uniprotkb:C19orf62(gene name synonym)|uniprotkb:NBA1(gene name synonym)|uniprotkb:Mediator of RAP80 interactions and targeting subunit of 40 kDa(gene name synonym)|uniprotkb:New component of the BRCA1-A complex(gene name synonym)|uniprotkb:MERIT40(gene name synonym) psi-mi:psa4_human(display_long)|uniprotkb:PSMA4(gene name)|psi-mi:PSMA4(display_short)|uniprotkb:PSC9(gene name synonym)|uniprotkb:Proteasome component C9(gene name synonym)|uniprotkb:Macropain subunit C9(gene name synonym)|uniprotkb:Multicatalytic endopeptidase complex subunit C9(gene name synonym)|uniprotkb:Proteasome subunit L(gene name synonym)|uniprotkb:HC9(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514464|imex:IM-12079-91 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001028721.1|refseq:NP_054892.2|ensembl:ENSG00000105393(gene)|ensembl:ENST00000359435(transcript)|ensembl:ENST00000598188(transcript)|ensembl:ENST00000601043(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006325"(chromatin organization)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016604"(nuclear body)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0051301"(cell division)|go:"GO:0070531"(BRCA1-A complex)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0070552"(BRISC complex)|interpro:IPR026126|interpro:IPR036465|mint:Q9NWV8|rcsb pdb:6H3C|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473|refseq:NP_001275685.1|refseq:NP_001275686.1 refseq:NP_001096137.1|refseq:NP_002780.1|rcsb pdb:6XMJ|reactome:R-HSA-2467813|reactome:R-HSA-2871837|rcsb pdb:7AWE|reactome:R-HSA-349425|reactome:R-HSA-1169091|reactome:R-HSA-350562|reactome:R-HSA-1234176|reactome:R-HSA-382556|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-450408|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-4641258|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5358346|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168|ensembl:ENSG00000041357(gene)|ensembl:ENST00000044462(transcript)|ensembl:ENST00000559082(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005839"(proteasome core complex)|go:"GO:0010499"(proteasomal ubiquitin-independent protein catabolic process)|go:"GO:0019773"(proteasome core complex, alpha-subunit complex)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000426(Proteasome alpha-subunit, conserved site)|interpro:IPR001353(20S proteasome, A and B subunits)|interpro:IPR016050(Proteasome, beta-type subunit, conserved site)|interpro:IPR023332|interpro:IPR029055|interpro:IPR034647|mint:P25789|rcsb pdb:4R3O|rcsb pdb:4R67|rcsb pdb:5A0Q|rcsb pdb:5GJQ|rcsb pdb:5GJR|rcsb pdb:5L4G|rcsb pdb:5LE5|rcsb pdb:5LEX|rcsb pdb:5LEY|rcsb pdb:5LEZ|rcsb pdb:5LF0|rcsb pdb:5LF1|rcsb pdb:5LF3|rcsb pdb:5LF4|rcsb pdb:5LF6|go:"GO:0000502"(proteasome complex)|go:"GO:0000932"(P-body)|rcsb pdb:5LF7|rcsb pdb:5LN3|rcsb pdb:5M32|rcsb pdb:5T0C|rcsb pdb:5T0G|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004298"(threonine-type endopeptidase activity)|rcsb pdb:5T0H|rcsb pdb:5T0I|rcsb pdb:5T0J|rcsb pdb:5VFO|rcsb pdb:5VFP|rcsb pdb:5VFQ|rcsb pdb:5VFR|rcsb pdb:5VFS|rcsb pdb:5VFT|rcsb pdb:5VFU|rcsb pdb:6AVO|rcsb pdb:6E5B|rcsb pdb:6KWY|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6MSH|rcsb pdb:6MSJ|rcsb pdb:6MSK|rcsb pdb:6R70|rcsb pdb:6REY|rcsb pdb:6RGQ|rcsb pdb:6WJD|rcsb pdb:6WJN|refseq:NP_001096138.1|refseq:NP_001317605.1|dip:DIP-29365N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:o71OvjzuL/7w4247ap7fm6i3pXU9606 rogid:u+wKxvIa9JKb4Zu9K+tnY3d26tw9606 intact-crc:2F9E49C582BB9C1C|rigid:trNYDYqpT7OPgee2YiBJgfHUhqw false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9NWV8 uniprotkb:Q6UWZ7 intact:EBI-745725|uniprotkb:Q6FIA0|uniprotkb:Q9P018|uniprotkb:A8MQT0|uniprotkb:B4DRY9|uniprotkb:B4DVR1|ensembl:ENSP00000352408|ensembl:ENSP00000470920|ensembl:ENSP00000471605 intact:EBI-1263451|uniprotkb:Q9H8I1|uniprotkb:Q9H9N4|uniprotkb:A5JJ07|ensembl:ENSP00000369857 psi-mi:baba1_human(display_long)|uniprotkb:BABAM1(gene name)|psi-mi:BABAM1(display_short)|uniprotkb:HSPC142(orf name)|uniprotkb:C19orf62(gene name synonym)|uniprotkb:NBA1(gene name synonym)|uniprotkb:Mediator of RAP80 interactions and targeting subunit of 40 kDa(gene name synonym)|uniprotkb:New component of the BRCA1-A complex(gene name synonym)|uniprotkb:MERIT40(gene name synonym) psi-mi:abrx1_human(display_long)|uniprotkb:ABRAXAS1(gene name)|psi-mi:ABRAXAS1(display_short)|uniprotkb:ABRA1(gene name synonym)|uniprotkb:CCDC98(gene name synonym)|uniprotkb:Coiled-coil domain-containing protein 98(gene name synonym)|uniprotkb:FAM175A(gene name synonym)|uniprotkb:Protein FAM175A(gene name synonym)|uniprotkb:UNQ496/PRO1013(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514464|imex:IM-12079-91 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001028721.1|refseq:NP_054892.2|ensembl:ENSG00000105393(gene)|ensembl:ENST00000359435(transcript)|ensembl:ENST00000598188(transcript)|ensembl:ENST00000601043(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006325"(chromatin organization)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016604"(nuclear body)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0051301"(cell division)|go:"GO:0070531"(BRCA1-A complex)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0070552"(BRISC complex)|interpro:IPR026126|interpro:IPR036465|mint:Q9NWV8|rcsb pdb:6H3C|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473|refseq:NP_001275685.1|refseq:NP_001275686.1 dip:DIP-29615N|refseq:NP_620775.2|refseq:NP_001332891.1|ensembl:ENSG00000163322(gene)|ensembl:ENST00000321945(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006325"(chromatin organization)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0008017"(microtubule binding)|go:"GO:0008608"(attachment of spindle microtubules to kinetochore)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016604"(nuclear body)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0070531"(BRCA1-A complex)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0090307"(mitotic spindle assembly)|interpro:IPR023238|interpro:IPR023239|interpro:IPR037518|rcsb pdb:4JLU|rcsb pdb:4U4A|rcsb pdb:4Y18|rcsb pdb:4Y2G|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473 psi-mi:"MI:0469"(intact) - caution:This sequence has been withdrawn from Uniprot. figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:o71OvjzuL/7w4247ap7fm6i3pXU9606 rogid:ZD7wQnqzfRv9owR8/zdgrMP5W6c9606 intact-crc:2F9E49C582BB9C1C|rigid:trNYDYqpT7OPgee2YiBJgfHUhqw false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8WZ19 uniprotkb:Q13829 intact:EBI-742916|ensembl:ENSP00000311202|ensembl:ENSP00000455785|uniprotkb:Q96P93|uniprotkb:Q96SA1|uniprotkb:A8K0R5 intact:EBI-2505861|uniprotkb:B7Z6M4|uniprotkb:Q5TZQ1|ensembl:ENSP00000226225 psi-mi:bacd1_human(display_long)|uniprotkb:Polymerase delta-interacting protein 1(gene name synonym)|uniprotkb:TNFAIP1-like protein(gene name synonym)|uniprotkb:KCTD13(gene name)|psi-mi:KCTD13(display_short)|uniprotkb:PDIP1(gene name synonym)|uniprotkb:POLDIP1(gene name synonym)|uniprotkb:FKSG86(orf name)|uniprotkb:PP6832(orf name)|uniprotkb:BACURD1(gene name synonym)|uniprotkb:BTB/POZ domain-containing protein KCTD13(gene name synonym) psi-mi:bacd2_human(display_long)|uniprotkb:BACURD2(gene name synonym)|uniprotkb:BTB/POZ domain-containing protein TNFAIP1(gene name synonym)|uniprotkb:Protein B12(gene name synonym)|uniprotkb:TNFAIP1(gene name)|psi-mi:TNFAIP1(display_short)|uniprotkb:EDP1(gene name synonym)|uniprotkb:Tumor necrosis factor, alpha-induced protein 1, endothelial(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514554|imex:IM-12079-41 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_849194.1|ensembl:ENSG00000174943(gene)|ensembl:ENST00000308768(transcript)|ensembl:ENST00000568000(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016477"(cell migration)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051260"(protein homooligomerization)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR003131(Potassium channel, voltage dependent, Kv, tetramerisation)|interpro:IPR011333(BTB/POZ fold)|mint:Q8WZ19|rcsb pdb:4UIJ|reactome:R-HSA-9696264|reactome:R-HSA-9696270 refseq:NP_066960.1|ensembl:ENSG00000109079(gene)|ensembl:ENST00000226225(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0006955"(immune response)|go:"GO:0016477"(cell migration)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030332"(cyclin binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0051260"(protein homooligomerization)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR003131(Potassium channel, voltage dependent, Kv, tetramerisation)|interpro:IPR011333(BTB/POZ fold)|mint:Q13829|reactome:R-HSA-9696264|reactome:R-HSA-9696270 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:hAH5yJEoda0H1anmnSXWHO0o1ZM9606 rogid:8vM9HnNmkirDbJRETV/TeE8pONY9606 intact-crc:F6B104E72120B3D5|rigid:HckG3z23ILwNdCC42/VZLrs8qGQ false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8WZ19 uniprotkb:Q9H3F6 intact:EBI-742916|ensembl:ENSP00000311202|ensembl:ENSP00000455785|uniprotkb:Q96P93|uniprotkb:Q96SA1|uniprotkb:A8K0R5 intact:EBI-2505886|uniprotkb:Q53HN2|uniprotkb:Q59FV1|uniprotkb:Q6PL47|uniprotkb:Q96SU0|intact:EBI-2563423|ensembl:ENSP00000228495 psi-mi:bacd1_human(display_long)|uniprotkb:Polymerase delta-interacting protein 1(gene name synonym)|uniprotkb:TNFAIP1-like protein(gene name synonym)|uniprotkb:KCTD13(gene name)|psi-mi:KCTD13(display_short)|uniprotkb:PDIP1(gene name synonym)|uniprotkb:POLDIP1(gene name synonym)|uniprotkb:FKSG86(orf name)|uniprotkb:PP6832(orf name)|uniprotkb:BACURD1(gene name synonym)|uniprotkb:BTB/POZ domain-containing protein KCTD13(gene name synonym) psi-mi:bacd3_human(display_long)|uniprotkb:BTB/POZ domain-containing protein KCTD10(gene name synonym)|uniprotkb:Potassium channel tetramerization domain-containing protein 10(gene name synonym)|uniprotkb:KCTD10(gene name)|psi-mi:KCTD10(display_short)|uniprotkb:ULR061(gene name synonym)|uniprotkb:MSTP028(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514554|imex:IM-12079-41 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_849194.1|ensembl:ENSG00000174943(gene)|ensembl:ENST00000308768(transcript)|ensembl:ENST00000568000(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016477"(cell migration)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051260"(protein homooligomerization)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR003131(Potassium channel, voltage dependent, Kv, tetramerisation)|interpro:IPR011333(BTB/POZ fold)|mint:Q8WZ19|rcsb pdb:4UIJ|reactome:R-HSA-9696264|reactome:R-HSA-9696270 refseq:NP_001304324.1|refseq:NP_001304328.1|refseq:NP_114160.1|ensembl:ENSG00000110906(gene)|ensembl:ENST00000228495(transcript)|go:"GO:0005112"(Notch binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0051260"(protein homooligomerization)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR003131(Potassium channel, voltage dependent, Kv, tetramerisation)|interpro:IPR011333(BTB/POZ fold)|rcsb pdb:5FTA psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:hAH5yJEoda0H1anmnSXWHO0o1ZM9606 rogid:ol+Pl17F/3aoKl1CD+edgT9KweI9606 intact-crc:F6B104E72120B3D5|rigid:HckG3z23ILwNdCC42/VZLrs8qGQ false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8WZ19 uniprotkb:P78539 intact:EBI-742916|ensembl:ENSP00000311202|ensembl:ENSP00000455785|uniprotkb:Q96P93|uniprotkb:Q96SA1|uniprotkb:A8K0R5 intact:EBI-2371213|uniprotkb:Q4VX66|uniprotkb:Q99652|uniprotkb:Q99913|uniprotkb:A8K065|uniprotkb:B4DQH5|uniprotkb:B4DDB8|uniprotkb:F5H4D7|uniprotkb:B3KWP8|uniprotkb:G3V1L0|ensembl:ENSP00000367794 psi-mi:bacd1_human(display_long)|uniprotkb:Polymerase delta-interacting protein 1(gene name synonym)|uniprotkb:TNFAIP1-like protein(gene name synonym)|uniprotkb:KCTD13(gene name)|psi-mi:KCTD13(display_short)|uniprotkb:PDIP1(gene name synonym)|uniprotkb:POLDIP1(gene name synonym)|uniprotkb:FKSG86(orf name)|uniprotkb:PP6832(orf name)|uniprotkb:BACURD1(gene name synonym)|uniprotkb:BTB/POZ domain-containing protein KCTD13(gene name synonym) psi-mi:srpx_human(display_long)|uniprotkb:SRPX(gene name)|psi-mi:SRPX(display_short)|uniprotkb:ETX1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514554|imex:IM-12079-41 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_849194.1|ensembl:ENSG00000174943(gene)|ensembl:ENST00000308768(transcript)|ensembl:ENST00000568000(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016477"(cell migration)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051260"(protein homooligomerization)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR003131(Potassium channel, voltage dependent, Kv, tetramerisation)|interpro:IPR011333(BTB/POZ fold)|mint:Q8WZ19|rcsb pdb:4UIJ|reactome:R-HSA-9696264|reactome:R-HSA-9696270 refseq:NP_001164221.1|refseq:NP_006298.1|refseq:NP_001164222.1|refseq:NP_001164223.1|ensembl:ENSG00000101955(gene)|ensembl:ENST00000378533(transcript)|go:"GO:0001845"(phagolysosome assembly)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006914"(autophagy)|go:"GO:0007155"(cell adhesion)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0060244"(negative regulation of cell proliferation involved in contact inhibition)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000436(Sushi/SCR/CCP)|interpro:IPR003410(Hyalin)|interpro:IPR025232|interpro:IPR035976|interpro:IPR036981|interpro:IPR043555 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:hAH5yJEoda0H1anmnSXWHO0o1ZM9606 rogid:xMO7Kxy17NsHmML5HETICRb8ba09606 intact-crc:F6B104E72120B3D5|rigid:HckG3z23ILwNdCC42/VZLrs8qGQ false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8WZ19 uniprotkb:Q15149 intact:EBI-742916|ensembl:ENSP00000311202|ensembl:ENSP00000455785|uniprotkb:Q96P93|uniprotkb:Q96SA1|uniprotkb:A8K0R5 intact:EBI-297903|intact:EBI-1103289|intact:EBI-1103265|intact:EBI-1055056|uniprotkb:Q15148|uniprotkb:Q16640|ensembl:ENSP00000323856|uniprotkb:Q6S376|intact:EBI-28976159|uniprotkb:Q6S380|intact:EBI-1103313|uniprotkb:Q6S377|uniprotkb:Q6S378|uniprotkb:Q6S379|intact:EBI-1103301|intact:EBI-1103253|uniprotkb:Q6S381|uniprotkb:Q6S382|uniprotkb:Q6S383|intact:EBI-2825763 psi-mi:bacd1_human(display_long)|uniprotkb:Polymerase delta-interacting protein 1(gene name synonym)|uniprotkb:TNFAIP1-like protein(gene name synonym)|uniprotkb:KCTD13(gene name)|psi-mi:KCTD13(display_short)|uniprotkb:PDIP1(gene name synonym)|uniprotkb:POLDIP1(gene name synonym)|uniprotkb:FKSG86(orf name)|uniprotkb:PP6832(orf name)|uniprotkb:BACURD1(gene name synonym)|uniprotkb:BTB/POZ domain-containing protein KCTD13(gene name synonym) psi-mi:plec_human(display_long)|uniprotkb:PLEC(gene name)|psi-mi:PLEC(display_short)|uniprotkb:Hemidesmosomal protein 1(gene name synonym)|uniprotkb:PLEC1(gene name synonym)|uniprotkb:Plectin-1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514554|imex:IM-12079-41 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_849194.1|ensembl:ENSG00000174943(gene)|ensembl:ENST00000308768(transcript)|ensembl:ENST00000568000(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016477"(cell migration)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051260"(protein homooligomerization)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR003131(Potassium channel, voltage dependent, Kv, tetramerisation)|interpro:IPR011333(BTB/POZ fold)|mint:Q8WZ19|rcsb pdb:4UIJ|reactome:R-HSA-9696264|reactome:R-HSA-9696270 go:"GO:0030018"(Z disc)|go:"GO:0030056"(hemidesmosome)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030506"(ankyrin binding)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031581"(hemidesmosome assembly)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0032094"(response to food)|go:"GO:0032287"(peripheral nervous system myelin maintenance)|go:"GO:0034332"(adherens junction organization)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0042060"(wound healing)|go:"GO:0042383"(sarcolemma)|go:"GO:0043034"(costamere)|go:"GO:0043114"(regulation of vascular permeability)|go:"GO:0043209"(myelin sheath)|go:"GO:0043621"(protein self-association)|go:"GO:0043933"(protein-containing complex organization)|go:"GO:0045104"(intermediate filament cytoskeleton organization)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0045214"(sarcomere organization)|go:"GO:0045296"(cadherin binding)|go:"GO:0045445"(myoblast differentiation)|go:"GO:0048471"(perinuclear region of cytoplasm)|ensembl:ENSG00000178209(gene)|ensembl:ENST00000322810(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0002162"(dystroglycan binding)|go:"GO:0002522"(leukocyte migration involved in immune response)|go:"GO:0003334"(keratinocyte development)|go:"GO:0003723"(RNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005737"(cytoplasm)|go:"GO:0055013"(cardiac muscle cell development)|go:"GO:0061436"(establishment of skin barrier)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070584"(mitochondrion morphogenesis)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071464"(cellular response to hydrostatic pressure)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0120193"(tight junction organization)|go:"GO:2000689"(actomyosin contractile ring assembly actin filament organization)|go:"GO:2000983"(regulation of ATP citrate synthase activity)|interpro:IPR001101(Plectin repeat)|interpro:IPR001452(Src homology-3)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR005326(Plectin/S10, N-terminal)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005925"(focal adhesion)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006997"(nucleus organization)|go:"GO:0008307"(structural constituent of muscle)|go:"GO:0010467"(gene expression)|go:"GO:0010761"(fibroblast migration)|go:"GO:0010818"(T cell chemotaxis)|go:"GO:0014866"(skeletal myofibril assembly)|go:"GO:0016020"(membrane)|go:"GO:0016528"(sarcoplasm)|go:"GO:0016569"(obsolete covalent chromatin modification)|go:"GO:0019226"(transmission of nerve impulse)|interpro:IPR030269|interpro:IPR035915|interpro:IPR018159|interpro:IPR036388|interpro:IPR036872|interpro:IPR041573|interpro:IPR041615|interpro:IPR043197|mint:Q15149|rcsb pdb:1MB8|rcsb pdb:2N03|rcsb pdb:2ODU|rcsb pdb:2ODV|rcsb pdb:3F7P|rcsb pdb:3PDY|rcsb pdb:3PE0|rcsb pdb:4GDO|rcsb pdb:4Q58|rcsb pdb:4Q59|rcsb pdb:5J1F|rcsb pdb:5J1G|rcsb pdb:5J1H|rcsb pdb:5J1I|reactome:R-HSA-2022090|reactome:R-HSA-264870|reactome:R-HSA-446107|ensembl:ENST00000436759|ensembl:ENSP00000388180|ensembl:ENST00000527096|ensembl:ENSP00000434583|ensembl:ENSP00000323856|ensembl:ENST00000345136|ensembl:ENSP00000344848|ensembl:ENST00000354589|ensembl:ENSP00000346602|ensembl:ENST00000354958|ensembl:ENSP00000347044|ensembl:ENST00000356346|ensembl:ENSP00000348702|ensembl:ENST00000357649|ensembl:ENSP00000350277|ensembl:ENST00000398774|ensembl:ENSP00000381756|refseq:NP_000436.2|refseq:NP_958780.1|refseq:NP_958781.1|refseq:NP_958782.1|refseq:NP_958783.1|refseq:NP_958784.1|refseq:NP_958785.1|refseq:NP_958786.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:hAH5yJEoda0H1anmnSXWHO0o1ZM9606 rogid:zbctDAOOCaJUx3WBdp85v7SI0sI9606 intact-crc:F6B104E72120B3D5|rigid:HckG3z23ILwNdCC42/VZLrs8qGQ false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8WZ19 uniprotkb:A4D0S4 intact:EBI-742916|ensembl:ENSP00000311202|ensembl:ENSP00000455785|uniprotkb:Q96P93|uniprotkb:Q96SA1|uniprotkb:A8K0R5 intact:EBI-2514556|ensembl:ENSP00000205386|ensembl:ENSP00000373433|uniprotkb:Q86XN2|uniprotkb:A5PKU6|uniprotkb:B2RTT3|uniprotkb:Q8NBX5|uniprotkb:Q86TP7|uniprotkb:B5MEB9 psi-mi:bacd1_human(display_long)|uniprotkb:Polymerase delta-interacting protein 1(gene name synonym)|uniprotkb:TNFAIP1-like protein(gene name synonym)|uniprotkb:KCTD13(gene name)|psi-mi:KCTD13(display_short)|uniprotkb:PDIP1(gene name synonym)|uniprotkb:POLDIP1(gene name synonym)|uniprotkb:FKSG86(orf name)|uniprotkb:PP6832(orf name)|uniprotkb:BACURD1(gene name synonym)|uniprotkb:BTB/POZ domain-containing protein KCTD13(gene name synonym) psi-mi:lamb4_human(display_long)|uniprotkb:LAMB4(gene name)|psi-mi:LAMB4(display_short)|uniprotkb:Laminin beta-1-related protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514554|imex:IM-12079-41 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_849194.1|ensembl:ENSG00000174943(gene)|ensembl:ENST00000308768(transcript)|ensembl:ENST00000568000(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016477"(cell migration)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051260"(protein homooligomerization)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR003131(Potassium channel, voltage dependent, Kv, tetramerisation)|interpro:IPR011333(BTB/POZ fold)|mint:Q8WZ19|rcsb pdb:4UIJ|reactome:R-HSA-9696264|reactome:R-HSA-9696270 ensembl:ENSG00000091128(gene)|ensembl:ENST00000205386(transcript)|ensembl:ENST00000388781(transcript)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005576"(extracellular region)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009888"(tissue development)|go:"GO:0016477"(cell migration)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0043256"(laminin complex)|go:"GO:0070831"(basement membrane assembly)|interpro:IPR002049(EGF-like, laminin)|interpro:IPR008211(Laminin, N-terminal)|interpro:IPR013015(Laminin IV)|refseq:XP_011514280.1|refseq:NP_001304975.1|refseq:NP_001304977.1|refseq:NP_031382.2 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:hAH5yJEoda0H1anmnSXWHO0o1ZM9606 rogid:KOIYeHHeJ2iFsbwl7cX/ZbyMIJk9606 intact-crc:F6B104E72120B3D5|rigid:HckG3z23ILwNdCC42/VZLrs8qGQ false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q14145 uniprotkb:Q6UVJ0 intact:EBI-751001|uniprotkb:B3KPD5|uniprotkb:Q8WTX1|uniprotkb:Q6LEP0|uniprotkb:Q9BPY9|intact:EBI-28976014|ensembl:ENSP00000171111|ensembl:ENSP00000377245 intact:EBI-1570153|uniprotkb:Q8N3K0|uniprotkb:D3DT55|intact:EBI-2559998|ensembl:ENSP00000287482 psi-mi:keap1_human(display_long)|uniprotkb:Cytosolic inhibitor of Nrf2(gene name synonym)|uniprotkb:Kelch-like protein 19(gene name synonym)|uniprotkb:KEAP1(gene name)|psi-mi:KEAP1(display_short)|uniprotkb:INRF2(gene name synonym)|uniprotkb:KIAA0132(gene name synonym)|uniprotkb:KLHL19(gene name synonym) psi-mi:sas6_human(display_long)|uniprotkb:SASS6(gene name)|psi-mi:SASS6(display_short)|uniprotkb:SAS6(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514586|imex:IM-12079-92 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_036421.2|refseq:NP_987096.1|ensembl:ENSP00000171111|ensembl:ENSP00000377245|refseq:XP_011526754.1|refseq:XP_005260230.1|refseq:XP_005260231.1|dip:DIP-42134N|ensembl:ENSG00000079999(gene)|ensembl:ENST00000171111(transcript)|ensembl:ENST00000393623(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016234"(inclusion body)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030496"(midbody)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0042802"(identical protein binding)|go:"GO:0042994"(cytoplasmic sequestering of transcription factor)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045604"(regulation of epidermal cell differentiation)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0097718"(disordered domain specific binding)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR011705(BTB/Kelch-associated)|interpro:IPR015915(Kelch-type beta propeller)|interpro:IPR017096(Kelch-like protein, gigaxonin)|interpro:IPR030563|mint:Q14145|rcsb pdb:1U6D|rcsb pdb:1ZGK|rcsb pdb:2FLU|rcsb pdb:3VNG|rcsb pdb:3VNH|rcsb pdb:3ZGC|rcsb pdb:3ZGD|rcsb pdb:4CXI|rcsb pdb:4CXJ|rcsb pdb:4CXT|rcsb pdb:4IFJ|rcsb pdb:4IFL|rcsb pdb:4IFN|rcsb pdb:4IN4|rcsb pdb:4IQK|rcsb pdb:4L7B|rcsb pdb:4L7C|rcsb pdb:4L7D|rcsb pdb:4N1B|rcsb pdb:4XMB|rcsb pdb:5DAD|rcsb pdb:5DAF|rcsb pdb:5F72|rcsb pdb:5GIT|rcsb pdb:5NLB|rcsb pdb:5WFL|rcsb pdb:5WFV|rcsb pdb:5WG1|rcsb pdb:5WHL|rcsb pdb:5WHO|rcsb pdb:5WIY|rcsb pdb:5X54|rcsb pdb:6FFM|rcsb pdb:6FMP|rcsb pdb:6FMQ|rcsb pdb:6HWS|rcsb pdb:6LRZ|rcsb pdb:6ROG|rcsb pdb:6SP1|rcsb pdb:6SP4|rcsb pdb:6T7V|rcsb pdb:6T7Z|rcsb pdb:6TG8|rcsb pdb:6TYM|rcsb pdb:6TYP|rcsb pdb:6UF0|rcsb pdb:6W66|rcsb pdb:6W67|rcsb pdb:6W68|rcsb pdb:6W69|rcsb pdb:6WCQ|rcsb pdb:6Z6A|rcsb pdb:7K28|rcsb pdb:7K29|rcsb pdb:7K2A|rcsb pdb:7K2B|rcsb pdb:7K2C|rcsb pdb:7K2D|rcsb pdb:7K2E|rcsb pdb:7K2F|rcsb pdb:7K2G|rcsb pdb:7K2H|rcsb pdb:7K2I|rcsb pdb:7K2J|rcsb pdb:7K2K|rcsb pdb:7K2L|rcsb pdb:7K2M|rcsb pdb:7K2N|rcsb pdb:7K2O|rcsb pdb:7K2P|rcsb pdb:7K2Q|rcsb pdb:7K2R|rcsb pdb:7K2S|reactome:R-HSA-5689880|reactome:R-HSA-8932339|reactome:R-HSA-8951664|reactome:R-HSA-983168|rcsb pdb:6V6Z refseq:NP_919268.1|refseq:NP_001291758.1|ensembl:ENSG00000156876(gene)|ensembl:ENST00000287482(transcript)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0007099"(centriole replication)|go:"GO:0034451"(centriolar satellite)|go:"GO:0051298"(centrosome duplication)|go:"GO:0098536"(deuterosome)|interpro:IPR032396|interpro:IPR038558|interpro:IPR041513|mint:Q6UVJ0|rcsb pdb:6YS4|rcsb pdb:6Z4A psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:3y/KqnUK+5nIyjhOEfkkthmP1OA9606 rogid:CvTk9f+BMKJBZQjA/adeLD8Okn89606 intact-crc:4F87DA235BCF65DD|rigid:bVCZ9NLKY0r764/CL5vAz/VcNSw false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q14145 uniprotkb:P56270 intact:EBI-751001|uniprotkb:B3KPD5|uniprotkb:Q8WTX1|uniprotkb:Q6LEP0|uniprotkb:Q9BPY9|intact:EBI-28976014|ensembl:ENSP00000171111|ensembl:ENSP00000377245 intact:EBI-1809742|uniprotkb:A8QJL9|uniprotkb:Q15703|uniprotkb:Q99443|uniprotkb:H3BQD6|uniprotkb:G5E927|uniprotkb:Q8NFN7|uniprotkb:C6G496|ensembl:ENSP00000313362 psi-mi:keap1_human(display_long)|uniprotkb:Cytosolic inhibitor of Nrf2(gene name synonym)|uniprotkb:Kelch-like protein 19(gene name synonym)|uniprotkb:KEAP1(gene name)|psi-mi:KEAP1(display_short)|uniprotkb:INRF2(gene name synonym)|uniprotkb:KIAA0132(gene name synonym)|uniprotkb:KLHL19(gene name synonym) psi-mi:maz_human(display_long)|uniprotkb:Transcription factor Zif87(gene name synonym)|uniprotkb:Zinc finger protein 801(gene name synonym)|uniprotkb:MAZ(gene name)|psi-mi:MAZ(display_short)|uniprotkb:Purine-binding transcription factor(gene name synonym)|uniprotkb:Pur-1(gene name synonym)|uniprotkb:ZF87(gene name synonym)|uniprotkb:ZNF801(gene name synonym)|uniprotkb:Serum amyloid A-activating factor-1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514586|imex:IM-12079-92 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_036421.2|refseq:NP_987096.1|ensembl:ENSP00000171111|ensembl:ENSP00000377245|refseq:XP_011526754.1|refseq:XP_005260230.1|refseq:XP_005260231.1|dip:DIP-42134N|ensembl:ENSG00000079999(gene)|ensembl:ENST00000171111(transcript)|ensembl:ENST00000393623(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016234"(inclusion body)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030496"(midbody)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0042802"(identical protein binding)|go:"GO:0042994"(cytoplasmic sequestering of transcription factor)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045604"(regulation of epidermal cell differentiation)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0097718"(disordered domain specific binding)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR011705(BTB/Kelch-associated)|interpro:IPR015915(Kelch-type beta propeller)|interpro:IPR017096(Kelch-like protein, gigaxonin)|interpro:IPR030563|mint:Q14145|rcsb pdb:1U6D|rcsb pdb:1ZGK|rcsb pdb:2FLU|rcsb pdb:3VNG|rcsb pdb:3VNH|rcsb pdb:3ZGC|rcsb pdb:3ZGD|rcsb pdb:4CXI|rcsb pdb:4CXJ|rcsb pdb:4CXT|rcsb pdb:4IFJ|rcsb pdb:4IFL|rcsb pdb:4IFN|rcsb pdb:4IN4|rcsb pdb:4IQK|rcsb pdb:4L7B|rcsb pdb:4L7C|rcsb pdb:4L7D|rcsb pdb:4N1B|rcsb pdb:4XMB|rcsb pdb:5DAD|rcsb pdb:5DAF|rcsb pdb:5F72|rcsb pdb:5GIT|rcsb pdb:5NLB|rcsb pdb:5WFL|rcsb pdb:5WFV|rcsb pdb:5WG1|rcsb pdb:5WHL|rcsb pdb:5WHO|rcsb pdb:5WIY|rcsb pdb:5X54|rcsb pdb:6FFM|rcsb pdb:6FMP|rcsb pdb:6FMQ|rcsb pdb:6HWS|rcsb pdb:6LRZ|rcsb pdb:6ROG|rcsb pdb:6SP1|rcsb pdb:6SP4|rcsb pdb:6T7V|rcsb pdb:6T7Z|rcsb pdb:6TG8|rcsb pdb:6TYM|rcsb pdb:6TYP|rcsb pdb:6UF0|rcsb pdb:6W66|rcsb pdb:6W67|rcsb pdb:6W68|rcsb pdb:6W69|rcsb pdb:6WCQ|rcsb pdb:6Z6A|rcsb pdb:7K28|rcsb pdb:7K29|rcsb pdb:7K2A|rcsb pdb:7K2B|rcsb pdb:7K2C|rcsb pdb:7K2D|rcsb pdb:7K2E|rcsb pdb:7K2F|rcsb pdb:7K2G|rcsb pdb:7K2H|rcsb pdb:7K2I|rcsb pdb:7K2J|rcsb pdb:7K2K|rcsb pdb:7K2L|rcsb pdb:7K2M|rcsb pdb:7K2N|rcsb pdb:7K2O|rcsb pdb:7K2P|rcsb pdb:7K2Q|rcsb pdb:7K2R|rcsb pdb:7K2S|reactome:R-HSA-5689880|reactome:R-HSA-8932339|reactome:R-HSA-8951664|reactome:R-HSA-983168|rcsb pdb:6V6Z refseq:NP_002374.2|refseq:NP_001036004.1|refseq:NP_001263205.1|refseq:NP_001263204.1|ensembl:ENSG00000103495(gene)|ensembl:ENST00000322945(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0006369"(termination of RNA polymerase II transcription)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|mint:P56270 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:3y/KqnUK+5nIyjhOEfkkthmP1OA9606 rogid:zuCDXhF2wr8gmTyjBNse9kVUqSw9606 intact-crc:4F87DA235BCF65DD|rigid:bVCZ9NLKY0r764/CL5vAz/VcNSw false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q14145 uniprotkb:A3KMH1 intact:EBI-751001|uniprotkb:B3KPD5|uniprotkb:Q8WTX1|uniprotkb:Q6LEP0|uniprotkb:Q9BPY9|intact:EBI-28976014|ensembl:ENSP00000171111|ensembl:ENSP00000377245 intact:EBI-308657|uniprotkb:Q5JTP6|uniprotkb:Q5VW08|uniprotkb:Q7Z6I9|uniprotkb:Q86YC9|uniprotkb:Q8N3E4|uniprotkb:O60310|ensembl:ENSP00000368612 psi-mi:keap1_human(display_long)|uniprotkb:Cytosolic inhibitor of Nrf2(gene name synonym)|uniprotkb:Kelch-like protein 19(gene name synonym)|uniprotkb:KEAP1(gene name)|psi-mi:KEAP1(display_short)|uniprotkb:INRF2(gene name synonym)|uniprotkb:KIAA0132(gene name synonym)|uniprotkb:KLHL19(gene name synonym) psi-mi:vwa8_human(display_long)|uniprotkb:VWA8(gene name)|psi-mi:VWA8(display_short)|uniprotkb:KIAA0564(gene name synonym)|uniprotkb:PEX7-binding protein 2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514586|imex:IM-12079-92 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_036421.2|refseq:NP_987096.1|ensembl:ENSP00000171111|ensembl:ENSP00000377245|refseq:XP_011526754.1|refseq:XP_005260230.1|refseq:XP_005260231.1|dip:DIP-42134N|ensembl:ENSG00000079999(gene)|ensembl:ENST00000171111(transcript)|ensembl:ENST00000393623(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016234"(inclusion body)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030496"(midbody)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0042802"(identical protein binding)|go:"GO:0042994"(cytoplasmic sequestering of transcription factor)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045604"(regulation of epidermal cell differentiation)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0097718"(disordered domain specific binding)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR011705(BTB/Kelch-associated)|interpro:IPR015915(Kelch-type beta propeller)|interpro:IPR017096(Kelch-like protein, gigaxonin)|interpro:IPR030563|mint:Q14145|rcsb pdb:1U6D|rcsb pdb:1ZGK|rcsb pdb:2FLU|rcsb pdb:3VNG|rcsb pdb:3VNH|rcsb pdb:3ZGC|rcsb pdb:3ZGD|rcsb pdb:4CXI|rcsb pdb:4CXJ|rcsb pdb:4CXT|rcsb pdb:4IFJ|rcsb pdb:4IFL|rcsb pdb:4IFN|rcsb pdb:4IN4|rcsb pdb:4IQK|rcsb pdb:4L7B|rcsb pdb:4L7C|rcsb pdb:4L7D|rcsb pdb:4N1B|rcsb pdb:4XMB|rcsb pdb:5DAD|rcsb pdb:5DAF|rcsb pdb:5F72|rcsb pdb:5GIT|rcsb pdb:5NLB|rcsb pdb:5WFL|rcsb pdb:5WFV|rcsb pdb:5WG1|rcsb pdb:5WHL|rcsb pdb:5WHO|rcsb pdb:5WIY|rcsb pdb:5X54|rcsb pdb:6FFM|rcsb pdb:6FMP|rcsb pdb:6FMQ|rcsb pdb:6HWS|rcsb pdb:6LRZ|rcsb pdb:6ROG|rcsb pdb:6SP1|rcsb pdb:6SP4|rcsb pdb:6T7V|rcsb pdb:6T7Z|rcsb pdb:6TG8|rcsb pdb:6TYM|rcsb pdb:6TYP|rcsb pdb:6UF0|rcsb pdb:6W66|rcsb pdb:6W67|rcsb pdb:6W68|rcsb pdb:6W69|rcsb pdb:6WCQ|rcsb pdb:6Z6A|rcsb pdb:7K28|rcsb pdb:7K29|rcsb pdb:7K2A|rcsb pdb:7K2B|rcsb pdb:7K2C|rcsb pdb:7K2D|rcsb pdb:7K2E|rcsb pdb:7K2F|rcsb pdb:7K2G|rcsb pdb:7K2H|rcsb pdb:7K2I|rcsb pdb:7K2J|rcsb pdb:7K2K|rcsb pdb:7K2L|rcsb pdb:7K2M|rcsb pdb:7K2N|rcsb pdb:7K2O|rcsb pdb:7K2P|rcsb pdb:7K2Q|rcsb pdb:7K2R|rcsb pdb:7K2S|reactome:R-HSA-5689880|reactome:R-HSA-8932339|reactome:R-HSA-8951664|reactome:R-HSA-983168|rcsb pdb:6V6Z ensembl:ENSG00000102763(gene)|ensembl:ENST00000379310(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005777"(peroxisome)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR011704(ATPase associated with various cellular activities, AAA-5)|interpro:IPR027417|interpro:IPR036465|interpro:IPR039891|refseq:NP_001009814.1|refseq:NP_055873.1|refseq:XP_016875963.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:3y/KqnUK+5nIyjhOEfkkthmP1OA9606 rogid:IOalBj68cHFF4BsViQ+eeXQZiRY9606 intact-crc:4F87DA235BCF65DD|rigid:bVCZ9NLKY0r764/CL5vAz/VcNSw false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q14145 uniprotkb:Q9Y678 intact:EBI-751001|uniprotkb:B3KPD5|uniprotkb:Q8WTX1|uniprotkb:Q6LEP0|uniprotkb:Q9BPY9|intact:EBI-28976014|ensembl:ENSP00000171111|ensembl:ENSP00000377245 intact:EBI-1049127|uniprotkb:A8K6M8|uniprotkb:B3KMF6|uniprotkb:Q54AC4|ensembl:ENSP00000325002 psi-mi:keap1_human(display_long)|uniprotkb:Cytosolic inhibitor of Nrf2(gene name synonym)|uniprotkb:Kelch-like protein 19(gene name synonym)|uniprotkb:KEAP1(gene name)|psi-mi:KEAP1(display_short)|uniprotkb:INRF2(gene name synonym)|uniprotkb:KIAA0132(gene name synonym)|uniprotkb:KLHL19(gene name synonym) psi-mi:copg1_human(display_long)|uniprotkb:COPG1(gene name)|psi-mi:COPG1(display_short)|uniprotkb:COPG(gene name synonym)|uniprotkb:Gamma-1-coat protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514586|imex:IM-12079-92 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_036421.2|refseq:NP_987096.1|ensembl:ENSP00000171111|ensembl:ENSP00000377245|refseq:XP_011526754.1|refseq:XP_005260230.1|refseq:XP_005260231.1|dip:DIP-42134N|ensembl:ENSG00000079999(gene)|ensembl:ENST00000171111(transcript)|ensembl:ENST00000393623(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016234"(inclusion body)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030496"(midbody)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0042802"(identical protein binding)|go:"GO:0042994"(cytoplasmic sequestering of transcription factor)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045604"(regulation of epidermal cell differentiation)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0097718"(disordered domain specific binding)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR011705(BTB/Kelch-associated)|interpro:IPR015915(Kelch-type beta propeller)|interpro:IPR017096(Kelch-like protein, gigaxonin)|interpro:IPR030563|mint:Q14145|rcsb pdb:1U6D|rcsb pdb:1ZGK|rcsb pdb:2FLU|rcsb pdb:3VNG|rcsb pdb:3VNH|rcsb pdb:3ZGC|rcsb pdb:3ZGD|rcsb pdb:4CXI|rcsb pdb:4CXJ|rcsb pdb:4CXT|rcsb pdb:4IFJ|rcsb pdb:4IFL|rcsb pdb:4IFN|rcsb pdb:4IN4|rcsb pdb:4IQK|rcsb pdb:4L7B|rcsb pdb:4L7C|rcsb pdb:4L7D|rcsb pdb:4N1B|rcsb pdb:4XMB|rcsb pdb:5DAD|rcsb pdb:5DAF|rcsb pdb:5F72|rcsb pdb:5GIT|rcsb pdb:5NLB|rcsb pdb:5WFL|rcsb pdb:5WFV|rcsb pdb:5WG1|rcsb pdb:5WHL|rcsb pdb:5WHO|rcsb pdb:5WIY|rcsb pdb:5X54|rcsb pdb:6FFM|rcsb pdb:6FMP|rcsb pdb:6FMQ|rcsb pdb:6HWS|rcsb pdb:6LRZ|rcsb pdb:6ROG|rcsb pdb:6SP1|rcsb pdb:6SP4|rcsb pdb:6T7V|rcsb pdb:6T7Z|rcsb pdb:6TG8|rcsb pdb:6TYM|rcsb pdb:6TYP|rcsb pdb:6UF0|rcsb pdb:6W66|rcsb pdb:6W67|rcsb pdb:6W68|rcsb pdb:6W69|rcsb pdb:6WCQ|rcsb pdb:6Z6A|rcsb pdb:7K28|rcsb pdb:7K29|rcsb pdb:7K2A|rcsb pdb:7K2B|rcsb pdb:7K2C|rcsb pdb:7K2D|rcsb pdb:7K2E|rcsb pdb:7K2F|rcsb pdb:7K2G|rcsb pdb:7K2H|rcsb pdb:7K2I|rcsb pdb:7K2J|rcsb pdb:7K2K|rcsb pdb:7K2L|rcsb pdb:7K2M|rcsb pdb:7K2N|rcsb pdb:7K2O|rcsb pdb:7K2P|rcsb pdb:7K2Q|rcsb pdb:7K2R|rcsb pdb:7K2S|reactome:R-HSA-5689880|reactome:R-HSA-8932339|reactome:R-HSA-8951664|reactome:R-HSA-983168|rcsb pdb:6V6Z refseq:NP_057212.1|ensembl:ENSG00000181789(gene)|ensembl:ENST00000314797(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006891"(intra-Golgi vesicle-mediated transport)|go:"GO:0009306"(protein secretion)|go:"GO:0030126"(COPI vesicle coat)|go:"GO:0030133"(transport vesicle)|go:"GO:0051683"(establishment of Golgi localization)|go:"GO:0072384"(organelle transport along microtubule)|interpro:IPR002553(Clathrin/coatomer adaptor, adaptin-like, N-terminal)|interpro:IPR009028(Clathrin/coatomer adaptor, adaptin-like, appendage, C-terminal subdomain)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR012295(Beta2-adaptin/TATA-box binding, C-terminal)|interpro:IPR013040(Coatomer, gamma subunit, appendage, Ig-like subdomain)|interpro:IPR013041(Clathrin/coatomer adaptor, adaptin-like, appendage, Ig-like subdomain)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR017106(Coatomer, gamma subunit)|interpro:IPR032154|interpro:IPR037067|mint:Q9Y678|rcsb pdb:1R4X|reactome:R-HSA-6807878|reactome:R-HSA-6811434|dip:DIP-29872N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:3y/KqnUK+5nIyjhOEfkkthmP1OA9606 rogid:P3wujl1rJH+o0vUUl/rLp0PEpMU9606 intact-crc:4F87DA235BCF65DD|rigid:bVCZ9NLKY0r764/CL5vAz/VcNSw false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q14145 uniprotkb:P48444 intact:EBI-751001|uniprotkb:B3KPD5|uniprotkb:Q8WTX1|uniprotkb:Q6LEP0|uniprotkb:Q9BPY9|intact:EBI-28976014|ensembl:ENSP00000171111|ensembl:ENSP00000377245 intact:EBI-1044491|ensembl:ENSP00000264028|uniprotkb:Q52M80|uniprotkb:B4E1X2|uniprotkb:E9PEU4 psi-mi:keap1_human(display_long)|uniprotkb:Cytosolic inhibitor of Nrf2(gene name synonym)|uniprotkb:Kelch-like protein 19(gene name synonym)|uniprotkb:KEAP1(gene name)|psi-mi:KEAP1(display_short)|uniprotkb:INRF2(gene name synonym)|uniprotkb:KIAA0132(gene name synonym)|uniprotkb:KLHL19(gene name synonym) psi-mi:copd_human(display_long)|uniprotkb:Delta-coat protein(gene name synonym)|uniprotkb:ARCN1(gene name)|psi-mi:ARCN1(display_short)|uniprotkb:COPD(gene name synonym)|uniprotkb:Archain(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514586|imex:IM-12079-92 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_036421.2|refseq:NP_987096.1|ensembl:ENSP00000171111|ensembl:ENSP00000377245|refseq:XP_011526754.1|refseq:XP_005260230.1|refseq:XP_005260231.1|dip:DIP-42134N|ensembl:ENSG00000079999(gene)|ensembl:ENST00000171111(transcript)|ensembl:ENST00000393623(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016234"(inclusion body)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030496"(midbody)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0042802"(identical protein binding)|go:"GO:0042994"(cytoplasmic sequestering of transcription factor)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045604"(regulation of epidermal cell differentiation)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0097718"(disordered domain specific binding)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR011705(BTB/Kelch-associated)|interpro:IPR015915(Kelch-type beta propeller)|interpro:IPR017096(Kelch-like protein, gigaxonin)|interpro:IPR030563|mint:Q14145|rcsb pdb:1U6D|rcsb pdb:1ZGK|rcsb pdb:2FLU|rcsb pdb:3VNG|rcsb pdb:3VNH|rcsb pdb:3ZGC|rcsb pdb:3ZGD|rcsb pdb:4CXI|rcsb pdb:4CXJ|rcsb pdb:4CXT|rcsb pdb:4IFJ|rcsb pdb:4IFL|rcsb pdb:4IFN|rcsb pdb:4IN4|rcsb pdb:4IQK|rcsb pdb:4L7B|rcsb pdb:4L7C|rcsb pdb:4L7D|rcsb pdb:4N1B|rcsb pdb:4XMB|rcsb pdb:5DAD|rcsb pdb:5DAF|rcsb pdb:5F72|rcsb pdb:5GIT|rcsb pdb:5NLB|rcsb pdb:5WFL|rcsb pdb:5WFV|rcsb pdb:5WG1|rcsb pdb:5WHL|rcsb pdb:5WHO|rcsb pdb:5WIY|rcsb pdb:5X54|rcsb pdb:6FFM|rcsb pdb:6FMP|rcsb pdb:6FMQ|rcsb pdb:6HWS|rcsb pdb:6LRZ|rcsb pdb:6ROG|rcsb pdb:6SP1|rcsb pdb:6SP4|rcsb pdb:6T7V|rcsb pdb:6T7Z|rcsb pdb:6TG8|rcsb pdb:6TYM|rcsb pdb:6TYP|rcsb pdb:6UF0|rcsb pdb:6W66|rcsb pdb:6W67|rcsb pdb:6W68|rcsb pdb:6W69|rcsb pdb:6WCQ|rcsb pdb:6Z6A|rcsb pdb:7K28|rcsb pdb:7K29|rcsb pdb:7K2A|rcsb pdb:7K2B|rcsb pdb:7K2C|rcsb pdb:7K2D|rcsb pdb:7K2E|rcsb pdb:7K2F|rcsb pdb:7K2G|rcsb pdb:7K2H|rcsb pdb:7K2I|rcsb pdb:7K2J|rcsb pdb:7K2K|rcsb pdb:7K2L|rcsb pdb:7K2M|rcsb pdb:7K2N|rcsb pdb:7K2O|rcsb pdb:7K2P|rcsb pdb:7K2Q|rcsb pdb:7K2R|rcsb pdb:7K2S|reactome:R-HSA-5689880|reactome:R-HSA-8932339|reactome:R-HSA-8951664|reactome:R-HSA-983168|rcsb pdb:6V6Z ensembl:ENSG00000095139(gene)|ensembl:ENST00000264028(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003723"(RNA binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0016020"(membrane)|go:"GO:0021691"(cerebellar Purkinje cell layer maturation)|go:"GO:0030126"(COPI vesicle coat)|go:"GO:0030133"(transport vesicle)|go:"GO:0043473"(pigmentation)|go:"GO:0051645"(Golgi localization)|interpro:IPR011012(Longin-like)|interpro:IPR022775|interpro:IPR027059|interpro:IPR028565|interpro:IPR036168|mint:P48444|reactome:R-HSA-6807878|reactome:R-HSA-6811434|refseq:NP_001135753.1|refseq:NP_001646.2|dip:DIP-50375N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:3y/KqnUK+5nIyjhOEfkkthmP1OA9606 rogid:67dTqyFC/zHDlTapW36OMyXbz0M9606 intact-crc:4F87DA235BCF65DD|rigid:bVCZ9NLKY0r764/CL5vAz/VcNSw false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q14145 uniprotkb:Q13257 intact:EBI-751001|uniprotkb:B3KPD5|uniprotkb:Q8WTX1|uniprotkb:Q6LEP0|uniprotkb:Q9BPY9|intact:EBI-28976014|ensembl:ENSP00000171111|ensembl:ENSP00000377245 intact:EBI-78203|intact:EBI-28969404|ensembl:ENSP00000296509|uniprotkb:Q53F56|uniprotkb:Q548X9|uniprotkb:Q6IRW7|uniprotkb:Q8IZX3 psi-mi:keap1_human(display_long)|uniprotkb:Cytosolic inhibitor of Nrf2(gene name synonym)|uniprotkb:Kelch-like protein 19(gene name synonym)|uniprotkb:KEAP1(gene name)|psi-mi:KEAP1(display_short)|uniprotkb:INRF2(gene name synonym)|uniprotkb:KIAA0132(gene name synonym)|uniprotkb:KLHL19(gene name synonym) psi-mi:md2l1_human(display_long)|uniprotkb:MAD2L1(gene name)|psi-mi:MAD2L1(display_short)|uniprotkb:MAD2(gene name synonym)|uniprotkb:Mitotic arrest deficient 2-like protein 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514586|imex:IM-12079-92 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_036421.2|refseq:NP_987096.1|ensembl:ENSP00000171111|ensembl:ENSP00000377245|refseq:XP_011526754.1|refseq:XP_005260230.1|refseq:XP_005260231.1|dip:DIP-42134N|ensembl:ENSG00000079999(gene)|ensembl:ENST00000171111(transcript)|ensembl:ENST00000393623(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016234"(inclusion body)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030496"(midbody)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0042802"(identical protein binding)|go:"GO:0042994"(cytoplasmic sequestering of transcription factor)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045604"(regulation of epidermal cell differentiation)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0097718"(disordered domain specific binding)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR011705(BTB/Kelch-associated)|interpro:IPR015915(Kelch-type beta propeller)|interpro:IPR017096(Kelch-like protein, gigaxonin)|interpro:IPR030563|mint:Q14145|rcsb pdb:1U6D|rcsb pdb:1ZGK|rcsb pdb:2FLU|rcsb pdb:3VNG|rcsb pdb:3VNH|rcsb pdb:3ZGC|rcsb pdb:3ZGD|rcsb pdb:4CXI|rcsb pdb:4CXJ|rcsb pdb:4CXT|rcsb pdb:4IFJ|rcsb pdb:4IFL|rcsb pdb:4IFN|rcsb pdb:4IN4|rcsb pdb:4IQK|rcsb pdb:4L7B|rcsb pdb:4L7C|rcsb pdb:4L7D|rcsb pdb:4N1B|rcsb pdb:4XMB|rcsb pdb:5DAD|rcsb pdb:5DAF|rcsb pdb:5F72|rcsb pdb:5GIT|rcsb pdb:5NLB|rcsb pdb:5WFL|rcsb pdb:5WFV|rcsb pdb:5WG1|rcsb pdb:5WHL|rcsb pdb:5WHO|rcsb pdb:5WIY|rcsb pdb:5X54|rcsb pdb:6FFM|rcsb pdb:6FMP|rcsb pdb:6FMQ|rcsb pdb:6HWS|rcsb pdb:6LRZ|rcsb pdb:6ROG|rcsb pdb:6SP1|rcsb pdb:6SP4|rcsb pdb:6T7V|rcsb pdb:6T7Z|rcsb pdb:6TG8|rcsb pdb:6TYM|rcsb pdb:6TYP|rcsb pdb:6UF0|rcsb pdb:6W66|rcsb pdb:6W67|rcsb pdb:6W68|rcsb pdb:6W69|rcsb pdb:6WCQ|rcsb pdb:6Z6A|rcsb pdb:7K28|rcsb pdb:7K29|rcsb pdb:7K2A|rcsb pdb:7K2B|rcsb pdb:7K2C|rcsb pdb:7K2D|rcsb pdb:7K2E|rcsb pdb:7K2F|rcsb pdb:7K2G|rcsb pdb:7K2H|rcsb pdb:7K2I|rcsb pdb:7K2J|rcsb pdb:7K2K|rcsb pdb:7K2L|rcsb pdb:7K2M|rcsb pdb:7K2N|rcsb pdb:7K2O|rcsb pdb:7K2P|rcsb pdb:7K2Q|rcsb pdb:7K2R|rcsb pdb:7K2S|reactome:R-HSA-5689880|reactome:R-HSA-8932339|reactome:R-HSA-8951664|reactome:R-HSA-983168|rcsb pdb:6V6Z ensembl:ENSG00000164109(gene)|ensembl:ENST00000296509(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000776"(kinetochore)|go:"GO:0000922"(spindle pole)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044615"(nuclear pore nuclear basket)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051301"(cell division)|go:"GO:0051660"(establishment of centrosome localization)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090267"(positive regulation of mitotic cell cycle spindle assembly checkpoint)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|interpro:IPR003511(DNA-binding HORMA)|interpro:IPR036570|mint:Q13257|rcsb pdb:1DUJ|rcsb pdb:1GO4|rcsb pdb:1S2H|rcsb pdb:1KLQ|rcsb pdb:2QYF|rcsb pdb:2V64|rcsb pdb:2VFX|rcsb pdb:3GMH|rcsb pdb:5KHU|rcsb pdb:5LCW|rcsb pdb:6F0X|rcsb pdb:6TLJ|reactome:R-HSA-141405|reactome:R-HSA-141430|reactome:R-HSA-141444|reactome:R-HSA-174184|reactome:R-HSA-176409|reactome:R-HSA-179409|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|ensembl:ENSP00000296509|ensembl:ENST00000333047|ensembl:ENSP00000332295|refseq:NP_002349.1|dip:DIP-29653N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:3y/KqnUK+5nIyjhOEfkkthmP1OA9606 rogid:FyL1tmJllOZ4gQvwWb96aV9PMFw9606 intact-crc:4F87DA235BCF65DD|rigid:bVCZ9NLKY0r764/CL5vAz/VcNSw false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q14145 uniprotkb:Q9NY33 intact:EBI-751001|uniprotkb:B3KPD5|uniprotkb:Q8WTX1|uniprotkb:Q6LEP0|uniprotkb:Q9BPY9|intact:EBI-28976014|ensembl:ENSP00000171111|ensembl:ENSP00000377245 intact:EBI-718333|ensembl:ENSP00000440502|uniprotkb:O95748|uniprotkb:Q969H2|uniprotkb:Q9BV67|uniprotkb:Q9HAL6|uniprotkb:B2RDB5|uniprotkb:B4DLX4|uniprotkb:F5H8L6 psi-mi:keap1_human(display_long)|uniprotkb:Cytosolic inhibitor of Nrf2(gene name synonym)|uniprotkb:Kelch-like protein 19(gene name synonym)|uniprotkb:KEAP1(gene name)|psi-mi:KEAP1(display_short)|uniprotkb:INRF2(gene name synonym)|uniprotkb:KIAA0132(gene name synonym)|uniprotkb:KLHL19(gene name synonym) psi-mi:dpp3_human(display_long)|uniprotkb:Dipeptidyl peptidase III(gene name synonym)|uniprotkb:Dipeptidyl aminopeptidase III(gene name synonym)|uniprotkb:Dipeptidyl arylamidase III(gene name synonym)|uniprotkb:Enkephalinase B(gene name synonym)|uniprotkb:DPP3(gene name)|psi-mi:DPP3(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514586|imex:IM-12079-92 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_036421.2|refseq:NP_987096.1|ensembl:ENSP00000171111|ensembl:ENSP00000377245|refseq:XP_011526754.1|refseq:XP_005260230.1|refseq:XP_005260231.1|dip:DIP-42134N|ensembl:ENSG00000079999(gene)|ensembl:ENST00000171111(transcript)|ensembl:ENST00000393623(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016234"(inclusion body)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030496"(midbody)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0042802"(identical protein binding)|go:"GO:0042994"(cytoplasmic sequestering of transcription factor)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045604"(regulation of epidermal cell differentiation)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0097718"(disordered domain specific binding)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR011705(BTB/Kelch-associated)|interpro:IPR015915(Kelch-type beta propeller)|interpro:IPR017096(Kelch-like protein, gigaxonin)|interpro:IPR030563|mint:Q14145|rcsb pdb:1U6D|rcsb pdb:1ZGK|rcsb pdb:2FLU|rcsb pdb:3VNG|rcsb pdb:3VNH|rcsb pdb:3ZGC|rcsb pdb:3ZGD|rcsb pdb:4CXI|rcsb pdb:4CXJ|rcsb pdb:4CXT|rcsb pdb:4IFJ|rcsb pdb:4IFL|rcsb pdb:4IFN|rcsb pdb:4IN4|rcsb pdb:4IQK|rcsb pdb:4L7B|rcsb pdb:4L7C|rcsb pdb:4L7D|rcsb pdb:4N1B|rcsb pdb:4XMB|rcsb pdb:5DAD|rcsb pdb:5DAF|rcsb pdb:5F72|rcsb pdb:5GIT|rcsb pdb:5NLB|rcsb pdb:5WFL|rcsb pdb:5WFV|rcsb pdb:5WG1|rcsb pdb:5WHL|rcsb pdb:5WHO|rcsb pdb:5WIY|rcsb pdb:5X54|rcsb pdb:6FFM|rcsb pdb:6FMP|rcsb pdb:6FMQ|rcsb pdb:6HWS|rcsb pdb:6LRZ|rcsb pdb:6ROG|rcsb pdb:6SP1|rcsb pdb:6SP4|rcsb pdb:6T7V|rcsb pdb:6T7Z|rcsb pdb:6TG8|rcsb pdb:6TYM|rcsb pdb:6TYP|rcsb pdb:6UF0|rcsb pdb:6W66|rcsb pdb:6W67|rcsb pdb:6W68|rcsb pdb:6W69|rcsb pdb:6WCQ|rcsb pdb:6Z6A|rcsb pdb:7K28|rcsb pdb:7K29|rcsb pdb:7K2A|rcsb pdb:7K2B|rcsb pdb:7K2C|rcsb pdb:7K2D|rcsb pdb:7K2E|rcsb pdb:7K2F|rcsb pdb:7K2G|rcsb pdb:7K2H|rcsb pdb:7K2I|rcsb pdb:7K2J|rcsb pdb:7K2K|rcsb pdb:7K2L|rcsb pdb:7K2M|rcsb pdb:7K2N|rcsb pdb:7K2O|rcsb pdb:7K2P|rcsb pdb:7K2Q|rcsb pdb:7K2R|rcsb pdb:7K2S|reactome:R-HSA-5689880|reactome:R-HSA-8932339|reactome:R-HSA-8951664|reactome:R-HSA-983168|rcsb pdb:6V6Z ensembl:ENST00000541961(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0008239"(dipeptidyl-peptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0070006"(metalloaminopeptidase activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR005317(Peptidase M49, dipeptidyl-peptidase III)|interpro:IPR039461|ensembl:ENSG00000254986(gene)|rcsb pdb:3FVY|rcsb pdb:3T6B|rcsb pdb:3T6J|rcsb pdb:5E2Q|rcsb pdb:5E33|refseq:NP_005691.2|refseq:NP_569710.2|rcsb pdb:5E3A|rcsb pdb:5E3C|rcsb pdb:5EGY|rcsb pdb:5EHH|refseq:NP_001243599.1|dip:DIP-53793N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:3y/KqnUK+5nIyjhOEfkkthmP1OA9606 rogid:D47IxsTssPT5bD1CPmb2K0Z3MJQ9606 intact-crc:4F87DA235BCF65DD|rigid:bVCZ9NLKY0r764/CL5vAz/VcNSw false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q14145 uniprotkb:Q13501 intact:EBI-751001|uniprotkb:B3KPD5|uniprotkb:Q8WTX1|uniprotkb:Q6LEP0|uniprotkb:Q9BPY9|intact:EBI-28976014|ensembl:ENSP00000171111|ensembl:ENSP00000377245 intact:EBI-307104|uniprotkb:Q13446|uniprotkb:Q9BUV7|uniprotkb:Q9BVS6|uniprotkb:Q9UEU1|uniprotkb:A6NFN7|uniprotkb:B2R661|uniprotkb:B3KUW5|intact:EBI-28976133|ensembl:ENSP00000374455 psi-mi:keap1_human(display_long)|uniprotkb:Cytosolic inhibitor of Nrf2(gene name synonym)|uniprotkb:Kelch-like protein 19(gene name synonym)|uniprotkb:KEAP1(gene name)|psi-mi:KEAP1(display_short)|uniprotkb:INRF2(gene name synonym)|uniprotkb:KIAA0132(gene name synonym)|uniprotkb:KLHL19(gene name synonym) psi-mi:sqstm_human(display_long)|uniprotkb:SQSTM1(gene name)|psi-mi:SQSTM1(display_short)|uniprotkb:ORCA(gene name synonym)|uniprotkb:OSIL(gene name synonym)|uniprotkb:Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa(gene name synonym)|uniprotkb:Ubiquitin-binding protein p62(gene name synonym)|uniprotkb:EBI3-associated protein of 60 kDa(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514586|imex:IM-12079-92 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_036421.2|refseq:NP_987096.1|ensembl:ENSP00000171111|ensembl:ENSP00000377245|refseq:XP_011526754.1|refseq:XP_005260230.1|refseq:XP_005260231.1|dip:DIP-42134N|ensembl:ENSG00000079999(gene)|ensembl:ENST00000171111(transcript)|ensembl:ENST00000393623(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016234"(inclusion body)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030496"(midbody)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0042802"(identical protein binding)|go:"GO:0042994"(cytoplasmic sequestering of transcription factor)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045604"(regulation of epidermal cell differentiation)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0097718"(disordered domain specific binding)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR011705(BTB/Kelch-associated)|interpro:IPR015915(Kelch-type beta propeller)|interpro:IPR017096(Kelch-like protein, gigaxonin)|interpro:IPR030563|mint:Q14145|rcsb pdb:1U6D|rcsb pdb:1ZGK|rcsb pdb:2FLU|rcsb pdb:3VNG|rcsb pdb:3VNH|rcsb pdb:3ZGC|rcsb pdb:3ZGD|rcsb pdb:4CXI|rcsb pdb:4CXJ|rcsb pdb:4CXT|rcsb pdb:4IFJ|rcsb pdb:4IFL|rcsb pdb:4IFN|rcsb pdb:4IN4|rcsb pdb:4IQK|rcsb pdb:4L7B|rcsb pdb:4L7C|rcsb pdb:4L7D|rcsb pdb:4N1B|rcsb pdb:4XMB|rcsb pdb:5DAD|rcsb pdb:5DAF|rcsb pdb:5F72|rcsb pdb:5GIT|rcsb pdb:5NLB|rcsb pdb:5WFL|rcsb pdb:5WFV|rcsb pdb:5WG1|rcsb pdb:5WHL|rcsb pdb:5WHO|rcsb pdb:5WIY|rcsb pdb:5X54|rcsb pdb:6FFM|rcsb pdb:6FMP|rcsb pdb:6FMQ|rcsb pdb:6HWS|rcsb pdb:6LRZ|rcsb pdb:6ROG|rcsb pdb:6SP1|rcsb pdb:6SP4|rcsb pdb:6T7V|rcsb pdb:6T7Z|rcsb pdb:6TG8|rcsb pdb:6TYM|rcsb pdb:6TYP|rcsb pdb:6UF0|rcsb pdb:6W66|rcsb pdb:6W67|rcsb pdb:6W68|rcsb pdb:6W69|rcsb pdb:6WCQ|rcsb pdb:6Z6A|rcsb pdb:7K28|rcsb pdb:7K29|rcsb pdb:7K2A|rcsb pdb:7K2B|rcsb pdb:7K2C|rcsb pdb:7K2D|rcsb pdb:7K2E|rcsb pdb:7K2F|rcsb pdb:7K2G|rcsb pdb:7K2H|rcsb pdb:7K2I|rcsb pdb:7K2J|rcsb pdb:7K2K|rcsb pdb:7K2L|rcsb pdb:7K2M|rcsb pdb:7K2N|rcsb pdb:7K2O|rcsb pdb:7K2P|rcsb pdb:7K2Q|rcsb pdb:7K2R|rcsb pdb:7K2S|reactome:R-HSA-5689880|reactome:R-HSA-8932339|reactome:R-HSA-8951664|reactome:R-HSA-983168|rcsb pdb:6V6Z ensembl:ENST00000360718|ensembl:ENSP00000353944|ensembl:ENSP00000374455|ensembl:ENSG00000161011(gene)|ensembl:ENST00000389805(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000423"(mitophagy)|go:"GO:0000932"(P-body)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002376"(immune system process)|go:"GO:0002931"(response to ischemia)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0007032"(endosome organization)|go:"GO:0008104"(protein localization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0016197"(endosomal transport)|go:"GO:0016234"(inclusion body)|go:"GO:0016235"(aggresome)|go:"GO:0016236"(macroautophagy)|go:"GO:0016605"(PML body)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030154"(cell differentiation)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035973"(aggrephagy)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046578"(regulation of Ras protein signal transduction)|go:"GO:0061635"(regulation of protein complex stability)|go:"GO:0061912"(selective autophagy)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0097225"(sperm midpiece)|go:"GO:0097413"(Lewy body)|go:"GO:0098780"(response to mitochondrial depolarisation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1905719"(protein localization to perinuclear region of cytoplasm)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000433(Zinc finger, ZZ-type)|interpro:IPR009060(UBA-like)|go:"GO:0043130"(ubiquitin binding)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR033741|go:"GO:0044753"(amphisome)|interpro:IPR034866|interpro:IPR043145|mint:Q13501|rcsb pdb:1Q02|rcsb pdb:2JY7|rcsb pdb:2JY8|rcsb pdb:2K0B|rcsb pdb:2KNV|go:"GO:0044754"(autolysosome)|rcsb pdb:4MJS|rcsb pdb:4UF8|rcsb pdb:4UF9|go:"GO:0044877"(protein-containing complex binding)|rcsb pdb:5YP7|rcsb pdb:5YP8|rcsb pdb:5YPA|rcsb pdb:5YPB|rcsb pdb:5YPC|rcsb pdb:5YPE|rcsb pdb:5YPF|rcsb pdb:5YPG|rcsb pdb:5YPH|rcsb pdb:6JM4|rcsb pdb:6KHZ|rcsb pdb:6MJ7|rcsb pdb:6TGY|rcsb pdb:6TH3|reactome:R-HSA-205043|reactome:R-HSA-209543|reactome:R-HSA-209560|reactome:R-HSA-5205685|reactome:R-HSA-9020702|reactome:R-HSA-9664873|refseq:NP_001135770.1|refseq:NP_001135771.1|refseq:NP_003891.1|dip:DIP-34443N|refseq:XP_016865499.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:3y/KqnUK+5nIyjhOEfkkthmP1OA9606 rogid:paIcBLmyiv1+D9QMym5MY3yc8MI9606 intact-crc:4F87DA235BCF65DD|rigid:bVCZ9NLKY0r764/CL5vAz/VcNSw false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q14145 uniprotkb:Q96TA1 intact:EBI-751001|uniprotkb:B3KPD5|uniprotkb:Q8WTX1|uniprotkb:Q6LEP0|uniprotkb:Q9BPY9|intact:EBI-28976014|ensembl:ENSP00000171111|ensembl:ENSP00000377245 intact:EBI-2514593|uniprotkb:Q4LE55|uniprotkb:Q5VVW7|intact:EBI-28984656|ensembl:ENSP00000362409|uniprotkb:Q9NT35|uniprotkb:Q9BUS2|uniprotkb:Q5VVW6 psi-mi:keap1_human(display_long)|uniprotkb:Cytosolic inhibitor of Nrf2(gene name synonym)|uniprotkb:Kelch-like protein 19(gene name synonym)|uniprotkb:KEAP1(gene name)|psi-mi:KEAP1(display_short)|uniprotkb:INRF2(gene name synonym)|uniprotkb:KIAA0132(gene name synonym)|uniprotkb:KLHL19(gene name synonym) psi-mi:niba2_human(display_long)|uniprotkb:NIBAN2(gene name)|psi-mi:NIBAN2(display_short)|uniprotkb:C9orf88(gene name synonym)|uniprotkb:FAM129B(gene name synonym)|uniprotkb:Meg-3(gene name synonym)|uniprotkb:Melanoma invasion by ERK(gene name synonym)|uniprotkb:Niban-like protein 1(gene name synonym)|uniprotkb:Protein FAM129B(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514586|imex:IM-12079-92 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_036421.2|refseq:NP_987096.1|ensembl:ENSP00000171111|ensembl:ENSP00000377245|refseq:XP_011526754.1|refseq:XP_005260230.1|refseq:XP_005260231.1|dip:DIP-42134N|ensembl:ENSG00000079999(gene)|ensembl:ENST00000171111(transcript)|ensembl:ENST00000393623(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016234"(inclusion body)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030496"(midbody)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0042802"(identical protein binding)|go:"GO:0042994"(cytoplasmic sequestering of transcription factor)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045604"(regulation of epidermal cell differentiation)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0097718"(disordered domain specific binding)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR011705(BTB/Kelch-associated)|interpro:IPR015915(Kelch-type beta propeller)|interpro:IPR017096(Kelch-like protein, gigaxonin)|interpro:IPR030563|mint:Q14145|rcsb pdb:1U6D|rcsb pdb:1ZGK|rcsb pdb:2FLU|rcsb pdb:3VNG|rcsb pdb:3VNH|rcsb pdb:3ZGC|rcsb pdb:3ZGD|rcsb pdb:4CXI|rcsb pdb:4CXJ|rcsb pdb:4CXT|rcsb pdb:4IFJ|rcsb pdb:4IFL|rcsb pdb:4IFN|rcsb pdb:4IN4|rcsb pdb:4IQK|rcsb pdb:4L7B|rcsb pdb:4L7C|rcsb pdb:4L7D|rcsb pdb:4N1B|rcsb pdb:4XMB|rcsb pdb:5DAD|rcsb pdb:5DAF|rcsb pdb:5F72|rcsb pdb:5GIT|rcsb pdb:5NLB|rcsb pdb:5WFL|rcsb pdb:5WFV|rcsb pdb:5WG1|rcsb pdb:5WHL|rcsb pdb:5WHO|rcsb pdb:5WIY|rcsb pdb:5X54|rcsb pdb:6FFM|rcsb pdb:6FMP|rcsb pdb:6FMQ|rcsb pdb:6HWS|rcsb pdb:6LRZ|rcsb pdb:6ROG|rcsb pdb:6SP1|rcsb pdb:6SP4|rcsb pdb:6T7V|rcsb pdb:6T7Z|rcsb pdb:6TG8|rcsb pdb:6TYM|rcsb pdb:6TYP|rcsb pdb:6UF0|rcsb pdb:6W66|rcsb pdb:6W67|rcsb pdb:6W68|rcsb pdb:6W69|rcsb pdb:6WCQ|rcsb pdb:6Z6A|rcsb pdb:7K28|rcsb pdb:7K29|rcsb pdb:7K2A|rcsb pdb:7K2B|rcsb pdb:7K2C|rcsb pdb:7K2D|rcsb pdb:7K2E|rcsb pdb:7K2F|rcsb pdb:7K2G|rcsb pdb:7K2H|rcsb pdb:7K2I|rcsb pdb:7K2J|rcsb pdb:7K2K|rcsb pdb:7K2L|rcsb pdb:7K2M|rcsb pdb:7K2N|rcsb pdb:7K2O|rcsb pdb:7K2P|rcsb pdb:7K2Q|rcsb pdb:7K2R|rcsb pdb:7K2S|reactome:R-HSA-5689880|reactome:R-HSA-8932339|reactome:R-HSA-8951664|reactome:R-HSA-983168|rcsb pdb:6V6Z go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR026088|mint:Q96TA1|rcsb pdb:7CTP|ensembl:ENSG00000136830(gene)|ensembl:ENST00000373312(transcript)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007411"(axon guidance)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0030154"(cell differentiation)|go:"GO:0030948"(negative regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0032274"(gonadotropin secretion)|go:"GO:0040019"(positive regulation of embryonic development)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044029"(hypomethylation of CpG island)|go:"GO:0045296"(cadherin binding)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048743"(positive regulation of skeletal muscle fiber development)|go:"GO:0070062"(extracellular exosome)|go:"GO:2000279"(negative regulation of DNA biosynthetic process)|refseq:NP_001030611.1|refseq:NP_073744.2|ensembl:ENSP00000362409|ensembl:ENST00000373314|ensembl:ENSP00000362411 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:3y/KqnUK+5nIyjhOEfkkthmP1OA9606 rogid:xdcw2BLz6uu0zyGi/NzvzPLrKUk9606 intact-crc:4F87DA235BCF65DD|rigid:bVCZ9NLKY0r764/CL5vAz/VcNSw false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q14145 uniprotkb:Q8IUH3 intact:EBI-751001|uniprotkb:B3KPD5|uniprotkb:Q8WTX1|uniprotkb:Q6LEP0|uniprotkb:Q9BPY9|intact:EBI-28976014|ensembl:ENSP00000171111|ensembl:ENSP00000377245 intact:EBI-2512147|ensembl:ENSP00000482083|uniprotkb:Q8NFC9|uniprotkb:Q6NYL0 psi-mi:keap1_human(display_long)|uniprotkb:Cytosolic inhibitor of Nrf2(gene name synonym)|uniprotkb:Kelch-like protein 19(gene name synonym)|uniprotkb:KEAP1(gene name)|psi-mi:KEAP1(display_short)|uniprotkb:INRF2(gene name synonym)|uniprotkb:KIAA0132(gene name synonym)|uniprotkb:KLHL19(gene name synonym) psi-mi:rbm45_human(display_long)|uniprotkb:RBM45(gene name)|psi-mi:RBM45(display_short)|uniprotkb:DRB1(gene name synonym)|uniprotkb:DRBP1(gene name synonym)|uniprotkb:RNA-binding motif protein 45(gene name synonym)|uniprotkb:Developmentally-regulated RNA-binding protein 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514586|imex:IM-12079-92 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_036421.2|refseq:NP_987096.1|ensembl:ENSP00000171111|ensembl:ENSP00000377245|refseq:XP_011526754.1|refseq:XP_005260230.1|refseq:XP_005260231.1|dip:DIP-42134N|ensembl:ENSG00000079999(gene)|ensembl:ENST00000171111(transcript)|ensembl:ENST00000393623(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016234"(inclusion body)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030496"(midbody)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0042802"(identical protein binding)|go:"GO:0042994"(cytoplasmic sequestering of transcription factor)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045604"(regulation of epidermal cell differentiation)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0097718"(disordered domain specific binding)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR011705(BTB/Kelch-associated)|interpro:IPR015915(Kelch-type beta propeller)|interpro:IPR017096(Kelch-like protein, gigaxonin)|interpro:IPR030563|mint:Q14145|rcsb pdb:1U6D|rcsb pdb:1ZGK|rcsb pdb:2FLU|rcsb pdb:3VNG|rcsb pdb:3VNH|rcsb pdb:3ZGC|rcsb pdb:3ZGD|rcsb pdb:4CXI|rcsb pdb:4CXJ|rcsb pdb:4CXT|rcsb pdb:4IFJ|rcsb pdb:4IFL|rcsb pdb:4IFN|rcsb pdb:4IN4|rcsb pdb:4IQK|rcsb pdb:4L7B|rcsb pdb:4L7C|rcsb pdb:4L7D|rcsb pdb:4N1B|rcsb pdb:4XMB|rcsb pdb:5DAD|rcsb pdb:5DAF|rcsb pdb:5F72|rcsb pdb:5GIT|rcsb pdb:5NLB|rcsb pdb:5WFL|rcsb pdb:5WFV|rcsb pdb:5WG1|rcsb pdb:5WHL|rcsb pdb:5WHO|rcsb pdb:5WIY|rcsb pdb:5X54|rcsb pdb:6FFM|rcsb pdb:6FMP|rcsb pdb:6FMQ|rcsb pdb:6HWS|rcsb pdb:6LRZ|rcsb pdb:6ROG|rcsb pdb:6SP1|rcsb pdb:6SP4|rcsb pdb:6T7V|rcsb pdb:6T7Z|rcsb pdb:6TG8|rcsb pdb:6TYM|rcsb pdb:6TYP|rcsb pdb:6UF0|rcsb pdb:6W66|rcsb pdb:6W67|rcsb pdb:6W68|rcsb pdb:6W69|rcsb pdb:6WCQ|rcsb pdb:6Z6A|rcsb pdb:7K28|rcsb pdb:7K29|rcsb pdb:7K2A|rcsb pdb:7K2B|rcsb pdb:7K2C|rcsb pdb:7K2D|rcsb pdb:7K2E|rcsb pdb:7K2F|rcsb pdb:7K2G|rcsb pdb:7K2H|rcsb pdb:7K2I|rcsb pdb:7K2J|rcsb pdb:7K2K|rcsb pdb:7K2L|rcsb pdb:7K2M|rcsb pdb:7K2N|rcsb pdb:7K2O|rcsb pdb:7K2P|rcsb pdb:7K2Q|rcsb pdb:7K2R|rcsb pdb:7K2S|reactome:R-HSA-5689880|reactome:R-HSA-8932339|reactome:R-HSA-8951664|reactome:R-HSA-983168|rcsb pdb:6V6Z ensembl:ENSG00000155636(gene)|ensembl:ENST00000616198(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0007399"(nervous system development)|go:"GO:0030154"(cell differentiation)|go:"GO:0042802"(identical protein binding)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR033101|interpro:IPR034203|interpro:IPR034206|interpro:IPR034207|interpro:IPR034208|interpro:IPR035979|mint:Q8IUH3|rcsb pdb:7CSX|rcsb pdb:7CSZ|go:"GO:0005634"(nucleus)|refseq:NP_694453.2|refseq:XP_005246344.1|refseq:XP_016858811.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:3y/KqnUK+5nIyjhOEfkkthmP1OA9606 rogid:8w7mWJ1ncdOyq9VCGIIYK3qapxY9606 intact-crc:4F87DA235BCF65DD|rigid:bVCZ9NLKY0r764/CL5vAz/VcNSw false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q14145 uniprotkb:Q9NX00 intact:EBI-751001|uniprotkb:B3KPD5|uniprotkb:Q8WTX1|uniprotkb:Q6LEP0|uniprotkb:Q9BPY9|intact:EBI-28976014|ensembl:ENSP00000171111|ensembl:ENSP00000377245 intact:EBI-2514588|ensembl:ENSP00000253047|uniprotkb:Q9BU41 psi-mi:keap1_human(display_long)|uniprotkb:Cytosolic inhibitor of Nrf2(gene name synonym)|uniprotkb:Kelch-like protein 19(gene name synonym)|uniprotkb:KEAP1(gene name)|psi-mi:KEAP1(display_short)|uniprotkb:INRF2(gene name synonym)|uniprotkb:KIAA0132(gene name synonym)|uniprotkb:KLHL19(gene name synonym) psi-mi:tm160_human(display_long)|uniprotkb:TMEM160(gene name)|psi-mi:TMEM160(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514586|imex:IM-12079-92 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_036421.2|refseq:NP_987096.1|ensembl:ENSP00000171111|ensembl:ENSP00000377245|refseq:XP_011526754.1|refseq:XP_005260230.1|refseq:XP_005260231.1|dip:DIP-42134N|ensembl:ENSG00000079999(gene)|ensembl:ENST00000171111(transcript)|ensembl:ENST00000393623(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016234"(inclusion body)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030496"(midbody)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0042802"(identical protein binding)|go:"GO:0042994"(cytoplasmic sequestering of transcription factor)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045604"(regulation of epidermal cell differentiation)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0097718"(disordered domain specific binding)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR011705(BTB/Kelch-associated)|interpro:IPR015915(Kelch-type beta propeller)|interpro:IPR017096(Kelch-like protein, gigaxonin)|interpro:IPR030563|mint:Q14145|rcsb pdb:1U6D|rcsb pdb:1ZGK|rcsb pdb:2FLU|rcsb pdb:3VNG|rcsb pdb:3VNH|rcsb pdb:3ZGC|rcsb pdb:3ZGD|rcsb pdb:4CXI|rcsb pdb:4CXJ|rcsb pdb:4CXT|rcsb pdb:4IFJ|rcsb pdb:4IFL|rcsb pdb:4IFN|rcsb pdb:4IN4|rcsb pdb:4IQK|rcsb pdb:4L7B|rcsb pdb:4L7C|rcsb pdb:4L7D|rcsb pdb:4N1B|rcsb pdb:4XMB|rcsb pdb:5DAD|rcsb pdb:5DAF|rcsb pdb:5F72|rcsb pdb:5GIT|rcsb pdb:5NLB|rcsb pdb:5WFL|rcsb pdb:5WFV|rcsb pdb:5WG1|rcsb pdb:5WHL|rcsb pdb:5WHO|rcsb pdb:5WIY|rcsb pdb:5X54|rcsb pdb:6FFM|rcsb pdb:6FMP|rcsb pdb:6FMQ|rcsb pdb:6HWS|rcsb pdb:6LRZ|rcsb pdb:6ROG|rcsb pdb:6SP1|rcsb pdb:6SP4|rcsb pdb:6T7V|rcsb pdb:6T7Z|rcsb pdb:6TG8|rcsb pdb:6TYM|rcsb pdb:6TYP|rcsb pdb:6UF0|rcsb pdb:6W66|rcsb pdb:6W67|rcsb pdb:6W68|rcsb pdb:6W69|rcsb pdb:6WCQ|rcsb pdb:6Z6A|rcsb pdb:7K28|rcsb pdb:7K29|rcsb pdb:7K2A|rcsb pdb:7K2B|rcsb pdb:7K2C|rcsb pdb:7K2D|rcsb pdb:7K2E|rcsb pdb:7K2F|rcsb pdb:7K2G|rcsb pdb:7K2H|rcsb pdb:7K2I|rcsb pdb:7K2J|rcsb pdb:7K2K|rcsb pdb:7K2L|rcsb pdb:7K2M|rcsb pdb:7K2N|rcsb pdb:7K2O|rcsb pdb:7K2P|rcsb pdb:7K2Q|rcsb pdb:7K2R|rcsb pdb:7K2S|reactome:R-HSA-5689880|reactome:R-HSA-8932339|reactome:R-HSA-8951664|reactome:R-HSA-983168|rcsb pdb:6V6Z ensembl:ENSG00000130748(gene)|ensembl:ENST00000253047(transcript)|go:"GO:0016021"(integral component of membrane)|interpro:IPR026801|refseq:NP_060324.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:3y/KqnUK+5nIyjhOEfkkthmP1OA9606 rogid:5PuVgGSb9lQAD5/1RS6csGdai0Q9606 intact-crc:4F87DA235BCF65DD|rigid:bVCZ9NLKY0r764/CL5vAz/VcNSw false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q14145 uniprotkb:P62495 intact:EBI-751001|uniprotkb:B3KPD5|uniprotkb:Q8WTX1|uniprotkb:Q6LEP0|uniprotkb:Q9BPY9|intact:EBI-28976014|ensembl:ENSP00000171111|ensembl:ENSP00000377245 intact:EBI-750990|intact:EBI-1047744|uniprotkb:B2R6B4|uniprotkb:D3DQC1|uniprotkb:P46055|uniprotkb:Q5M7Z7|uniprotkb:Q96CG1|ensembl:ENSP00000353741 psi-mi:keap1_human(display_long)|uniprotkb:Cytosolic inhibitor of Nrf2(gene name synonym)|uniprotkb:Kelch-like protein 19(gene name synonym)|uniprotkb:KEAP1(gene name)|psi-mi:KEAP1(display_short)|uniprotkb:INRF2(gene name synonym)|uniprotkb:KIAA0132(gene name synonym)|uniprotkb:KLHL19(gene name synonym) psi-mi:erf1_human(display_long)|uniprotkb:ETF1(gene name)|psi-mi:ETF1(display_short)|uniprotkb:ERF1(gene name synonym)|uniprotkb:Protein Cl1(gene name synonym)|uniprotkb:RF1(gene name synonym)|uniprotkb:SUP45L1(gene name synonym)|uniprotkb:TB3-1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514586|imex:IM-12079-92 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_036421.2|refseq:NP_987096.1|ensembl:ENSP00000171111|ensembl:ENSP00000377245|refseq:XP_011526754.1|refseq:XP_005260230.1|refseq:XP_005260231.1|dip:DIP-42134N|ensembl:ENSG00000079999(gene)|ensembl:ENST00000171111(transcript)|ensembl:ENST00000393623(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016234"(inclusion body)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030496"(midbody)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0042802"(identical protein binding)|go:"GO:0042994"(cytoplasmic sequestering of transcription factor)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045604"(regulation of epidermal cell differentiation)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0097718"(disordered domain specific binding)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR011705(BTB/Kelch-associated)|interpro:IPR015915(Kelch-type beta propeller)|interpro:IPR017096(Kelch-like protein, gigaxonin)|interpro:IPR030563|mint:Q14145|rcsb pdb:1U6D|rcsb pdb:1ZGK|rcsb pdb:2FLU|rcsb pdb:3VNG|rcsb pdb:3VNH|rcsb pdb:3ZGC|rcsb pdb:3ZGD|rcsb pdb:4CXI|rcsb pdb:4CXJ|rcsb pdb:4CXT|rcsb pdb:4IFJ|rcsb pdb:4IFL|rcsb pdb:4IFN|rcsb pdb:4IN4|rcsb pdb:4IQK|rcsb pdb:4L7B|rcsb pdb:4L7C|rcsb pdb:4L7D|rcsb pdb:4N1B|rcsb pdb:4XMB|rcsb pdb:5DAD|rcsb pdb:5DAF|rcsb pdb:5F72|rcsb pdb:5GIT|rcsb pdb:5NLB|rcsb pdb:5WFL|rcsb pdb:5WFV|rcsb pdb:5WG1|rcsb pdb:5WHL|rcsb pdb:5WHO|rcsb pdb:5WIY|rcsb pdb:5X54|rcsb pdb:6FFM|rcsb pdb:6FMP|rcsb pdb:6FMQ|rcsb pdb:6HWS|rcsb pdb:6LRZ|rcsb pdb:6ROG|rcsb pdb:6SP1|rcsb pdb:6SP4|rcsb pdb:6T7V|rcsb pdb:6T7Z|rcsb pdb:6TG8|rcsb pdb:6TYM|rcsb pdb:6TYP|rcsb pdb:6UF0|rcsb pdb:6W66|rcsb pdb:6W67|rcsb pdb:6W68|rcsb pdb:6W69|rcsb pdb:6WCQ|rcsb pdb:6Z6A|rcsb pdb:7K28|rcsb pdb:7K29|rcsb pdb:7K2A|rcsb pdb:7K2B|rcsb pdb:7K2C|rcsb pdb:7K2D|rcsb pdb:7K2E|rcsb pdb:7K2F|rcsb pdb:7K2G|rcsb pdb:7K2H|rcsb pdb:7K2I|rcsb pdb:7K2J|rcsb pdb:7K2K|rcsb pdb:7K2L|rcsb pdb:7K2M|rcsb pdb:7K2N|rcsb pdb:7K2O|rcsb pdb:7K2P|rcsb pdb:7K2Q|rcsb pdb:7K2R|rcsb pdb:7K2S|reactome:R-HSA-5689880|reactome:R-HSA-8932339|reactome:R-HSA-8951664|reactome:R-HSA-983168|rcsb pdb:6V6Z refseq:NP_004721.1|refseq:NP_001243231.1|refseq:NP_001278903.1|refseq:NP_001278904.1|refseq:XP_005271978.1|ensembl:ENSG00000120705(gene)|ensembl:ENST00000360541(transcript)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0002184"(cytoplasmic translational termination)|go:"GO:0003723"(RNA binding)|go:"GO:0003747"(translation release factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006415"(translational termination)|go:"GO:0006449"(regulation of translational termination)|go:"GO:0006479"(protein methylation)|go:"GO:0008079"(translation termination factor activity)|go:"GO:0016149"(translation release factor activity, codon specific)|go:"GO:0018444"(translation release factor complex)|go:"GO:0043022"(ribosome binding)|go:"GO:1990825"(sequence-specific mRNA binding)|interpro:IPR004403(Peptide chain release factor eRF/aRF subunit 1)|interpro:IPR005140(eRF1 domain 1)|interpro:IPR005141(eRF1 domain 2)|interpro:IPR005142(eRF1 domain 3)|interpro:IPR024049|interpro:IPR029064|interpro:IPR042226|mint:P62495|rcsb pdb:1DT9|rcsb pdb:2HST|rcsb pdb:2KTU|rcsb pdb:2KTV|rcsb pdb:2LGT|rcsb pdb:2LLX|rcsb pdb:2MQ6|rcsb pdb:2MQ9|rcsb pdb:3E1Y|rcsb pdb:3J5Y|rcsb pdb:3JAG|rcsb pdb:3JAH|rcsb pdb:3JAI|rcsb pdb:4D5N|rcsb pdb:4D61|rcsb pdb:5A8L|rcsb pdb:5LZT|rcsb pdb:5LZU|rcsb pdb:5LZV|rcsb pdb:6D90|rcsb pdb:6IP8|rcsb pdb:6XA1|rcsb pdb:6ZME|reactome:R-HSA-72764|reactome:R-HSA-9010553|reactome:R-HSA-975956|reactome:R-HSA-975957 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:3y/KqnUK+5nIyjhOEfkkthmP1OA9606 rogid:vUI2Eq2wx++5VxZ2MK1EQ0jnWMI9606 intact-crc:4F87DA235BCF65DD|rigid:bVCZ9NLKY0r764/CL5vAz/VcNSw false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q14145 uniprotkb:Q7L5D6 intact:EBI-751001|uniprotkb:B3KPD5|uniprotkb:Q8WTX1|uniprotkb:Q6LEP0|uniprotkb:Q9BPY9|intact:EBI-28976014|ensembl:ENSP00000171111|ensembl:ENSP00000377245 intact:EBI-711823|uniprotkb:A4D2Q1|uniprotkb:B3KNC7|uniprotkb:Q9UFC9|uniprotkb:Q9Y309|ensembl:ENSP00000265857 psi-mi:keap1_human(display_long)|uniprotkb:Cytosolic inhibitor of Nrf2(gene name synonym)|uniprotkb:Kelch-like protein 19(gene name synonym)|uniprotkb:KEAP1(gene name)|psi-mi:KEAP1(display_short)|uniprotkb:INRF2(gene name synonym)|uniprotkb:KIAA0132(gene name synonym)|uniprotkb:KLHL19(gene name synonym) psi-mi:get4_human(display_long)|uniprotkb:CEE(gene name synonym)|uniprotkb:Conserved edge-expressed protein(gene name synonym)|uniprotkb:GET4(gene name)|psi-mi:GET4(display_short)|uniprotkb:CGI-20(orf name)|uniprotkb:C7orf20(gene name synonym)|uniprotkb:TRC35(gene name synonym)|uniprotkb:Transmembrane domain recognition complex 35 kDa subunit(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514586|imex:IM-12079-92 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_036421.2|refseq:NP_987096.1|ensembl:ENSP00000171111|ensembl:ENSP00000377245|refseq:XP_011526754.1|refseq:XP_005260230.1|refseq:XP_005260231.1|dip:DIP-42134N|ensembl:ENSG00000079999(gene)|ensembl:ENST00000171111(transcript)|ensembl:ENST00000393623(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016234"(inclusion body)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030496"(midbody)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0042802"(identical protein binding)|go:"GO:0042994"(cytoplasmic sequestering of transcription factor)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045604"(regulation of epidermal cell differentiation)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0097718"(disordered domain specific binding)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR011705(BTB/Kelch-associated)|interpro:IPR015915(Kelch-type beta propeller)|interpro:IPR017096(Kelch-like protein, gigaxonin)|interpro:IPR030563|mint:Q14145|rcsb pdb:1U6D|rcsb pdb:1ZGK|rcsb pdb:2FLU|rcsb pdb:3VNG|rcsb pdb:3VNH|rcsb pdb:3ZGC|rcsb pdb:3ZGD|rcsb pdb:4CXI|rcsb pdb:4CXJ|rcsb pdb:4CXT|rcsb pdb:4IFJ|rcsb pdb:4IFL|rcsb pdb:4IFN|rcsb pdb:4IN4|rcsb pdb:4IQK|rcsb pdb:4L7B|rcsb pdb:4L7C|rcsb pdb:4L7D|rcsb pdb:4N1B|rcsb pdb:4XMB|rcsb pdb:5DAD|rcsb pdb:5DAF|rcsb pdb:5F72|rcsb pdb:5GIT|rcsb pdb:5NLB|rcsb pdb:5WFL|rcsb pdb:5WFV|rcsb pdb:5WG1|rcsb pdb:5WHL|rcsb pdb:5WHO|rcsb pdb:5WIY|rcsb pdb:5X54|rcsb pdb:6FFM|rcsb pdb:6FMP|rcsb pdb:6FMQ|rcsb pdb:6HWS|rcsb pdb:6LRZ|rcsb pdb:6ROG|rcsb pdb:6SP1|rcsb pdb:6SP4|rcsb pdb:6T7V|rcsb pdb:6T7Z|rcsb pdb:6TG8|rcsb pdb:6TYM|rcsb pdb:6TYP|rcsb pdb:6UF0|rcsb pdb:6W66|rcsb pdb:6W67|rcsb pdb:6W68|rcsb pdb:6W69|rcsb pdb:6WCQ|rcsb pdb:6Z6A|rcsb pdb:7K28|rcsb pdb:7K29|rcsb pdb:7K2A|rcsb pdb:7K2B|rcsb pdb:7K2C|rcsb pdb:7K2D|rcsb pdb:7K2E|rcsb pdb:7K2F|rcsb pdb:7K2G|rcsb pdb:7K2H|rcsb pdb:7K2I|rcsb pdb:7K2J|rcsb pdb:7K2K|rcsb pdb:7K2L|rcsb pdb:7K2M|rcsb pdb:7K2N|rcsb pdb:7K2O|rcsb pdb:7K2P|rcsb pdb:7K2Q|rcsb pdb:7K2R|rcsb pdb:7K2S|reactome:R-HSA-5689880|reactome:R-HSA-8932339|reactome:R-HSA-8951664|reactome:R-HSA-983168|rcsb pdb:6V6Z ensembl:ENSG00000239857(gene)|ensembl:ENST00000265857(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0045048"(protein insertion into ER membrane)|go:"GO:0051087"(chaperone binding)|go:"GO:0051220"(cytoplasmic sequestering of protein)|go:"GO:0071816"(tail-anchored membrane protein insertion into ER membrane)|go:"GO:0071818"(BAT3 complex)|go:"GO:1904378"(maintenance of unfolded protein involved in ERAD pathway)|interpro:IPR007317(Protein of unknown function DUF410)|interpro:IPR011990(Tetratricopeptide-like helical)|mint:Q7L5D6|rcsb pdb:6AU8|reactome:R-HSA-9609523|refseq:NP_057033.2 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:3y/KqnUK+5nIyjhOEfkkthmP1OA9606 rogid:WbZJTGrC2/fB4iOFLJYn9MIWZFA9606 intact-crc:4F87DA235BCF65DD|rigid:bVCZ9NLKY0r764/CL5vAz/VcNSw false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q14145 uniprotkb:Q96HS1 intact:EBI-751001|uniprotkb:B3KPD5|uniprotkb:Q8WTX1|uniprotkb:Q6LEP0|uniprotkb:Q9BPY9|intact:EBI-28976014|ensembl:ENSP00000171111|ensembl:ENSP00000377245 intact:EBI-713608|uniprotkb:Q96JB0|intact:EBI-2555528|ensembl:ENSP00000438465|uniprotkb:C9IZY7|uniprotkb:A9LN06 psi-mi:keap1_human(display_long)|uniprotkb:Cytosolic inhibitor of Nrf2(gene name synonym)|uniprotkb:Kelch-like protein 19(gene name synonym)|uniprotkb:KEAP1(gene name)|psi-mi:KEAP1(display_short)|uniprotkb:INRF2(gene name synonym)|uniprotkb:KIAA0132(gene name synonym)|uniprotkb:KLHL19(gene name synonym) psi-mi:pgam5_human(display_long)|uniprotkb:Bcl-XL-binding protein v68(gene name synonym)|uniprotkb:PGAM5(gene name)|psi-mi:PGAM5(display_short)|uniprotkb:Phosphoglycerate mutase family member 5(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514586|imex:IM-12079-92 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_036421.2|refseq:NP_987096.1|ensembl:ENSP00000171111|ensembl:ENSP00000377245|refseq:XP_011526754.1|refseq:XP_005260230.1|refseq:XP_005260231.1|dip:DIP-42134N|ensembl:ENSG00000079999(gene)|ensembl:ENST00000171111(transcript)|ensembl:ENST00000393623(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016234"(inclusion body)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030496"(midbody)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0042802"(identical protein binding)|go:"GO:0042994"(cytoplasmic sequestering of transcription factor)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045604"(regulation of epidermal cell differentiation)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0097718"(disordered domain specific binding)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR011705(BTB/Kelch-associated)|interpro:IPR015915(Kelch-type beta propeller)|interpro:IPR017096(Kelch-like protein, gigaxonin)|interpro:IPR030563|mint:Q14145|rcsb pdb:1U6D|rcsb pdb:1ZGK|rcsb pdb:2FLU|rcsb pdb:3VNG|rcsb pdb:3VNH|rcsb pdb:3ZGC|rcsb pdb:3ZGD|rcsb pdb:4CXI|rcsb pdb:4CXJ|rcsb pdb:4CXT|rcsb pdb:4IFJ|rcsb pdb:4IFL|rcsb pdb:4IFN|rcsb pdb:4IN4|rcsb pdb:4IQK|rcsb pdb:4L7B|rcsb pdb:4L7C|rcsb pdb:4L7D|rcsb pdb:4N1B|rcsb pdb:4XMB|rcsb pdb:5DAD|rcsb pdb:5DAF|rcsb pdb:5F72|rcsb pdb:5GIT|rcsb pdb:5NLB|rcsb pdb:5WFL|rcsb pdb:5WFV|rcsb pdb:5WG1|rcsb pdb:5WHL|rcsb pdb:5WHO|rcsb pdb:5WIY|rcsb pdb:5X54|rcsb pdb:6FFM|rcsb pdb:6FMP|rcsb pdb:6FMQ|rcsb pdb:6HWS|rcsb pdb:6LRZ|rcsb pdb:6ROG|rcsb pdb:6SP1|rcsb pdb:6SP4|rcsb pdb:6T7V|rcsb pdb:6T7Z|rcsb pdb:6TG8|rcsb pdb:6TYM|rcsb pdb:6TYP|rcsb pdb:6UF0|rcsb pdb:6W66|rcsb pdb:6W67|rcsb pdb:6W68|rcsb pdb:6W69|rcsb pdb:6WCQ|rcsb pdb:6Z6A|rcsb pdb:7K28|rcsb pdb:7K29|rcsb pdb:7K2A|rcsb pdb:7K2B|rcsb pdb:7K2C|rcsb pdb:7K2D|rcsb pdb:7K2E|rcsb pdb:7K2F|rcsb pdb:7K2G|rcsb pdb:7K2H|rcsb pdb:7K2I|rcsb pdb:7K2J|rcsb pdb:7K2K|rcsb pdb:7K2L|rcsb pdb:7K2M|rcsb pdb:7K2N|rcsb pdb:7K2O|rcsb pdb:7K2P|rcsb pdb:7K2Q|rcsb pdb:7K2R|rcsb pdb:7K2S|reactome:R-HSA-5689880|reactome:R-HSA-8932339|reactome:R-HSA-8951664|reactome:R-HSA-983168|rcsb pdb:6V6Z refseq:NP_001164014.1|refseq:NP_612642.2|ensembl:ENSG00000247077(gene)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016236"(macroautophagy)|go:"GO:0016791"(phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0070266"(necroptotic process)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|interpro:IPR013078(Phosphoglycerate mutase)|interpro:IPR029033|mint:Q96HS1|rcsb pdb:3MXO|rcsb pdb:3O0T|rcsb pdb:5MUF|rcsb pdb:6CNI|rcsb pdb:6CNL|reactome:R-HSA-8934903|ensembl:ENST00000498926(transcript)|dip:DIP-50735N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:3y/KqnUK+5nIyjhOEfkkthmP1OA9606 rogid:prE0I+tNIEjN9Y1NBZbh51DY2+Q9606 intact-crc:4F87DA235BCF65DD|rigid:bVCZ9NLKY0r764/CL5vAz/VcNSw false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q14145 uniprotkb:Q9Y3Q8 intact:EBI-751001|uniprotkb:B3KPD5|uniprotkb:Q8WTX1|uniprotkb:Q6LEP0|uniprotkb:Q9BPY9|intact:EBI-28976014|ensembl:ENSP00000171111|ensembl:ENSP00000377245 intact:EBI-739485|uniprotkb:A8MWR6|ensembl:ENSP00000300181|uniprotkb:A4D2C3|uniprotkb:D6W5V9 psi-mi:keap1_human(display_long)|uniprotkb:Cytosolic inhibitor of Nrf2(gene name synonym)|uniprotkb:Kelch-like protein 19(gene name synonym)|uniprotkb:KEAP1(gene name)|psi-mi:KEAP1(display_short)|uniprotkb:INRF2(gene name synonym)|uniprotkb:KIAA0132(gene name synonym)|uniprotkb:KLHL19(gene name synonym) psi-mi:t22d4_human(display_long)|uniprotkb:TSC22D4(gene name)|psi-mi:TSC22D4(display_short)|uniprotkb:TILZ2(gene name synonym)|uniprotkb:TSC22-related-inducible leucine zipper protein 2(gene name synonym)|uniprotkb:Tsc-22-like protein THG-1(gene name synonym)|uniprotkb:THG1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514586|imex:IM-12079-92 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_036421.2|refseq:NP_987096.1|ensembl:ENSP00000171111|ensembl:ENSP00000377245|refseq:XP_011526754.1|refseq:XP_005260230.1|refseq:XP_005260231.1|dip:DIP-42134N|ensembl:ENSG00000079999(gene)|ensembl:ENST00000171111(transcript)|ensembl:ENST00000393623(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016234"(inclusion body)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030496"(midbody)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0042802"(identical protein binding)|go:"GO:0042994"(cytoplasmic sequestering of transcription factor)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045604"(regulation of epidermal cell differentiation)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0097718"(disordered domain specific binding)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR011705(BTB/Kelch-associated)|interpro:IPR015915(Kelch-type beta propeller)|interpro:IPR017096(Kelch-like protein, gigaxonin)|interpro:IPR030563|mint:Q14145|rcsb pdb:1U6D|rcsb pdb:1ZGK|rcsb pdb:2FLU|rcsb pdb:3VNG|rcsb pdb:3VNH|rcsb pdb:3ZGC|rcsb pdb:3ZGD|rcsb pdb:4CXI|rcsb pdb:4CXJ|rcsb pdb:4CXT|rcsb pdb:4IFJ|rcsb pdb:4IFL|rcsb pdb:4IFN|rcsb pdb:4IN4|rcsb pdb:4IQK|rcsb pdb:4L7B|rcsb pdb:4L7C|rcsb pdb:4L7D|rcsb pdb:4N1B|rcsb pdb:4XMB|rcsb pdb:5DAD|rcsb pdb:5DAF|rcsb pdb:5F72|rcsb pdb:5GIT|rcsb pdb:5NLB|rcsb pdb:5WFL|rcsb pdb:5WFV|rcsb pdb:5WG1|rcsb pdb:5WHL|rcsb pdb:5WHO|rcsb pdb:5WIY|rcsb pdb:5X54|rcsb pdb:6FFM|rcsb pdb:6FMP|rcsb pdb:6FMQ|rcsb pdb:6HWS|rcsb pdb:6LRZ|rcsb pdb:6ROG|rcsb pdb:6SP1|rcsb pdb:6SP4|rcsb pdb:6T7V|rcsb pdb:6T7Z|rcsb pdb:6TG8|rcsb pdb:6TYM|rcsb pdb:6TYP|rcsb pdb:6UF0|rcsb pdb:6W66|rcsb pdb:6W67|rcsb pdb:6W68|rcsb pdb:6W69|rcsb pdb:6WCQ|rcsb pdb:6Z6A|rcsb pdb:7K28|rcsb pdb:7K29|rcsb pdb:7K2A|rcsb pdb:7K2B|rcsb pdb:7K2C|rcsb pdb:7K2D|rcsb pdb:7K2E|rcsb pdb:7K2F|rcsb pdb:7K2G|rcsb pdb:7K2H|rcsb pdb:7K2I|rcsb pdb:7K2J|rcsb pdb:7K2K|rcsb pdb:7K2L|rcsb pdb:7K2M|rcsb pdb:7K2N|rcsb pdb:7K2O|rcsb pdb:7K2P|rcsb pdb:7K2Q|rcsb pdb:7K2R|rcsb pdb:7K2S|reactome:R-HSA-5689880|reactome:R-HSA-8932339|reactome:R-HSA-8951664|reactome:R-HSA-983168|rcsb pdb:6V6Z ensembl:ENSG00000166925(gene)|ensembl:ENST00000300181(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006970"(response to osmotic stress)|interpro:IPR000580(TSC-22 / Dip / Bun)|interpro:IPR042553|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|refseq:NP_112197.1|refseq:NP_001289972.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:3y/KqnUK+5nIyjhOEfkkthmP1OA9606 rogid:eL12cHY76zEPOXzT1HFKPSckS8Y9606 intact-crc:4F87DA235BCF65DD|rigid:bVCZ9NLKY0r764/CL5vAz/VcNSw false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q14145 uniprotkb:O75323 intact:EBI-751001|uniprotkb:B3KPD5|uniprotkb:Q8WTX1|uniprotkb:Q6LEP0|uniprotkb:Q9BPY9|intact:EBI-28976014|ensembl:ENSP00000171111|ensembl:ENSP00000377245 intact:EBI-307133|uniprotkb:O43801|uniprotkb:Q53X96|uniprotkb:C9IYJ3|ensembl:ENSP00000313050 psi-mi:keap1_human(display_long)|uniprotkb:Cytosolic inhibitor of Nrf2(gene name synonym)|uniprotkb:Kelch-like protein 19(gene name synonym)|uniprotkb:KEAP1(gene name)|psi-mi:KEAP1(display_short)|uniprotkb:INRF2(gene name synonym)|uniprotkb:KIAA0132(gene name synonym)|uniprotkb:KLHL19(gene name synonym) psi-mi:nips2_human(display_long)|uniprotkb:NIPSNAP2(gene name)|psi-mi:NIPSNAP2(display_short)|uniprotkb:GBAS(gene name synonym)|uniprotkb:Glioblastoma-amplified sequence(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514586|imex:IM-12079-92 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_036421.2|refseq:NP_987096.1|ensembl:ENSP00000171111|ensembl:ENSP00000377245|refseq:XP_011526754.1|refseq:XP_005260230.1|refseq:XP_005260231.1|dip:DIP-42134N|ensembl:ENSG00000079999(gene)|ensembl:ENST00000171111(transcript)|ensembl:ENST00000393623(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016234"(inclusion body)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030496"(midbody)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0042802"(identical protein binding)|go:"GO:0042994"(cytoplasmic sequestering of transcription factor)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045604"(regulation of epidermal cell differentiation)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0097718"(disordered domain specific binding)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR011705(BTB/Kelch-associated)|interpro:IPR015915(Kelch-type beta propeller)|interpro:IPR017096(Kelch-like protein, gigaxonin)|interpro:IPR030563|mint:Q14145|rcsb pdb:1U6D|rcsb pdb:1ZGK|rcsb pdb:2FLU|rcsb pdb:3VNG|rcsb pdb:3VNH|rcsb pdb:3ZGC|rcsb pdb:3ZGD|rcsb pdb:4CXI|rcsb pdb:4CXJ|rcsb pdb:4CXT|rcsb pdb:4IFJ|rcsb pdb:4IFL|rcsb pdb:4IFN|rcsb pdb:4IN4|rcsb pdb:4IQK|rcsb pdb:4L7B|rcsb pdb:4L7C|rcsb pdb:4L7D|rcsb pdb:4N1B|rcsb pdb:4XMB|rcsb pdb:5DAD|rcsb pdb:5DAF|rcsb pdb:5F72|rcsb pdb:5GIT|rcsb pdb:5NLB|rcsb pdb:5WFL|rcsb pdb:5WFV|rcsb pdb:5WG1|rcsb pdb:5WHL|rcsb pdb:5WHO|rcsb pdb:5WIY|rcsb pdb:5X54|rcsb pdb:6FFM|rcsb pdb:6FMP|rcsb pdb:6FMQ|rcsb pdb:6HWS|rcsb pdb:6LRZ|rcsb pdb:6ROG|rcsb pdb:6SP1|rcsb pdb:6SP4|rcsb pdb:6T7V|rcsb pdb:6T7Z|rcsb pdb:6TG8|rcsb pdb:6TYM|rcsb pdb:6TYP|rcsb pdb:6UF0|rcsb pdb:6W66|rcsb pdb:6W67|rcsb pdb:6W68|rcsb pdb:6W69|rcsb pdb:6WCQ|rcsb pdb:6Z6A|rcsb pdb:7K28|rcsb pdb:7K29|rcsb pdb:7K2A|rcsb pdb:7K2B|rcsb pdb:7K2C|rcsb pdb:7K2D|rcsb pdb:7K2E|rcsb pdb:7K2F|rcsb pdb:7K2G|rcsb pdb:7K2H|rcsb pdb:7K2I|rcsb pdb:7K2J|rcsb pdb:7K2K|rcsb pdb:7K2L|rcsb pdb:7K2M|rcsb pdb:7K2N|rcsb pdb:7K2O|rcsb pdb:7K2P|rcsb pdb:7K2Q|rcsb pdb:7K2R|rcsb pdb:7K2S|reactome:R-HSA-5689880|reactome:R-HSA-8932339|reactome:R-HSA-8951664|reactome:R-HSA-983168|rcsb pdb:6V6Z refseq:NP_001189398.1|refseq:NP_001474.1|go:"GO:0006119"(oxidative phosphorylation)|go:"GO:0007005"(mitochondrion organization)|go:"GO:1901843"(positive regulation of high voltage-gated calcium channel activity)|interpro:IPR011008(Dimeric alpha-beta barrel)|interpro:IPR012577(NIPSNAP)|mint:O75323|reactome:R-HSA-9013407|reactome:R-HSA-9013409|ensembl:ENSG00000146729(gene)|ensembl:ENST00000322090(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|dip:DIP-33564N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:3y/KqnUK+5nIyjhOEfkkthmP1OA9606 rogid:sfBQGdtSVoH21kBu/Bz9x8x3KWU9606 intact-crc:4F87DA235BCF65DD|rigid:bVCZ9NLKY0r764/CL5vAz/VcNSw false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q14145 uniprotkb:Q9BTE3 intact:EBI-751001|uniprotkb:B3KPD5|uniprotkb:Q8WTX1|uniprotkb:Q6LEP0|uniprotkb:Q9BPY9|intact:EBI-28976014|ensembl:ENSP00000171111|ensembl:ENSP00000377245 intact:EBI-749378|uniprotkb:Q6IA56|uniprotkb:Q9BVT9|uniprotkb:Q9H916|uniprotkb:B3KSP7|ensembl:ENSP00000353098 psi-mi:keap1_human(display_long)|uniprotkb:Cytosolic inhibitor of Nrf2(gene name synonym)|uniprotkb:Kelch-like protein 19(gene name synonym)|uniprotkb:KEAP1(gene name)|psi-mi:KEAP1(display_short)|uniprotkb:INRF2(gene name synonym)|uniprotkb:KIAA0132(gene name synonym)|uniprotkb:KLHL19(gene name synonym) psi-mi:mcmbp_human(display_long)|uniprotkb:MCMBP(gene name)|psi-mi:MCMBP(display_short)|uniprotkb:C10orf119(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514586|imex:IM-12079-92 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_036421.2|refseq:NP_987096.1|ensembl:ENSP00000171111|ensembl:ENSP00000377245|refseq:XP_011526754.1|refseq:XP_005260230.1|refseq:XP_005260231.1|dip:DIP-42134N|ensembl:ENSG00000079999(gene)|ensembl:ENST00000171111(transcript)|ensembl:ENST00000393623(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016234"(inclusion body)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030496"(midbody)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0042802"(identical protein binding)|go:"GO:0042994"(cytoplasmic sequestering of transcription factor)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045604"(regulation of epidermal cell differentiation)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0097718"(disordered domain specific binding)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR011705(BTB/Kelch-associated)|interpro:IPR015915(Kelch-type beta propeller)|interpro:IPR017096(Kelch-like protein, gigaxonin)|interpro:IPR030563|mint:Q14145|rcsb pdb:1U6D|rcsb pdb:1ZGK|rcsb pdb:2FLU|rcsb pdb:3VNG|rcsb pdb:3VNH|rcsb pdb:3ZGC|rcsb pdb:3ZGD|rcsb pdb:4CXI|rcsb pdb:4CXJ|rcsb pdb:4CXT|rcsb pdb:4IFJ|rcsb pdb:4IFL|rcsb pdb:4IFN|rcsb pdb:4IN4|rcsb pdb:4IQK|rcsb pdb:4L7B|rcsb pdb:4L7C|rcsb pdb:4L7D|rcsb pdb:4N1B|rcsb pdb:4XMB|rcsb pdb:5DAD|rcsb pdb:5DAF|rcsb pdb:5F72|rcsb pdb:5GIT|rcsb pdb:5NLB|rcsb pdb:5WFL|rcsb pdb:5WFV|rcsb pdb:5WG1|rcsb pdb:5WHL|rcsb pdb:5WHO|rcsb pdb:5WIY|rcsb pdb:5X54|rcsb pdb:6FFM|rcsb pdb:6FMP|rcsb pdb:6FMQ|rcsb pdb:6HWS|rcsb pdb:6LRZ|rcsb pdb:6ROG|rcsb pdb:6SP1|rcsb pdb:6SP4|rcsb pdb:6T7V|rcsb pdb:6T7Z|rcsb pdb:6TG8|rcsb pdb:6TYM|rcsb pdb:6TYP|rcsb pdb:6UF0|rcsb pdb:6W66|rcsb pdb:6W67|rcsb pdb:6W68|rcsb pdb:6W69|rcsb pdb:6WCQ|rcsb pdb:6Z6A|rcsb pdb:7K28|rcsb pdb:7K29|rcsb pdb:7K2A|rcsb pdb:7K2B|rcsb pdb:7K2C|rcsb pdb:7K2D|rcsb pdb:7K2E|rcsb pdb:7K2F|rcsb pdb:7K2G|rcsb pdb:7K2H|rcsb pdb:7K2I|rcsb pdb:7K2J|rcsb pdb:7K2K|rcsb pdb:7K2L|rcsb pdb:7K2M|rcsb pdb:7K2N|rcsb pdb:7K2O|rcsb pdb:7K2P|rcsb pdb:7K2Q|rcsb pdb:7K2R|rcsb pdb:7K2S|reactome:R-HSA-5689880|reactome:R-HSA-8932339|reactome:R-HSA-8951664|reactome:R-HSA-983168|rcsb pdb:6V6Z refseq:NP_079110.1|refseq:NP_001243307.1|refseq:NP_001243308.1|ensembl:ENSG00000197771(gene)|ensembl:ENST00000360003(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0030054"(cell junction)|go:"GO:0051301"(cell division)|interpro:IPR019140|rcsb pdb:4KG9 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:3y/KqnUK+5nIyjhOEfkkthmP1OA9606 rogid:8mXHWwvrQneZZArPvAEj1JZwOrg9606 intact-crc:4F87DA235BCF65DD|rigid:bVCZ9NLKY0r764/CL5vAz/VcNSw false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q14145 uniprotkb:Q6ZTH0 intact:EBI-751001|uniprotkb:B3KPD5|uniprotkb:Q8WTX1|uniprotkb:Q6LEP0|uniprotkb:Q9BPY9|intact:EBI-28976014|ensembl:ENSP00000171111|ensembl:ENSP00000377245 intact:EBI-2514583 psi-mi:keap1_human(display_long)|uniprotkb:Cytosolic inhibitor of Nrf2(gene name synonym)|uniprotkb:Kelch-like protein 19(gene name synonym)|uniprotkb:KEAP1(gene name)|psi-mi:KEAP1(display_short)|uniprotkb:INRF2(gene name synonym)|uniprotkb:KIAA0132(gene name synonym)|uniprotkb:KLHL19(gene name synonym) psi-mi:q6zth0_human(display_long) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514586|imex:IM-12079-92 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_036421.2|refseq:NP_987096.1|ensembl:ENSP00000171111|ensembl:ENSP00000377245|refseq:XP_011526754.1|refseq:XP_005260230.1|refseq:XP_005260231.1|dip:DIP-42134N|ensembl:ENSG00000079999(gene)|ensembl:ENST00000171111(transcript)|ensembl:ENST00000393623(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016234"(inclusion body)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030496"(midbody)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0042802"(identical protein binding)|go:"GO:0042994"(cytoplasmic sequestering of transcription factor)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045604"(regulation of epidermal cell differentiation)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0097718"(disordered domain specific binding)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR011705(BTB/Kelch-associated)|interpro:IPR015915(Kelch-type beta propeller)|interpro:IPR017096(Kelch-like protein, gigaxonin)|interpro:IPR030563|mint:Q14145|rcsb pdb:1U6D|rcsb pdb:1ZGK|rcsb pdb:2FLU|rcsb pdb:3VNG|rcsb pdb:3VNH|rcsb pdb:3ZGC|rcsb pdb:3ZGD|rcsb pdb:4CXI|rcsb pdb:4CXJ|rcsb pdb:4CXT|rcsb pdb:4IFJ|rcsb pdb:4IFL|rcsb pdb:4IFN|rcsb pdb:4IN4|rcsb pdb:4IQK|rcsb pdb:4L7B|rcsb pdb:4L7C|rcsb pdb:4L7D|rcsb pdb:4N1B|rcsb pdb:4XMB|rcsb pdb:5DAD|rcsb pdb:5DAF|rcsb pdb:5F72|rcsb pdb:5GIT|rcsb pdb:5NLB|rcsb pdb:5WFL|rcsb pdb:5WFV|rcsb pdb:5WG1|rcsb pdb:5WHL|rcsb pdb:5WHO|rcsb pdb:5WIY|rcsb pdb:5X54|rcsb pdb:6FFM|rcsb pdb:6FMP|rcsb pdb:6FMQ|rcsb pdb:6HWS|rcsb pdb:6LRZ|rcsb pdb:6ROG|rcsb pdb:6SP1|rcsb pdb:6SP4|rcsb pdb:6T7V|rcsb pdb:6T7Z|rcsb pdb:6TG8|rcsb pdb:6TYM|rcsb pdb:6TYP|rcsb pdb:6UF0|rcsb pdb:6W66|rcsb pdb:6W67|rcsb pdb:6W68|rcsb pdb:6W69|rcsb pdb:6WCQ|rcsb pdb:6Z6A|rcsb pdb:7K28|rcsb pdb:7K29|rcsb pdb:7K2A|rcsb pdb:7K2B|rcsb pdb:7K2C|rcsb pdb:7K2D|rcsb pdb:7K2E|rcsb pdb:7K2F|rcsb pdb:7K2G|rcsb pdb:7K2H|rcsb pdb:7K2I|rcsb pdb:7K2J|rcsb pdb:7K2K|rcsb pdb:7K2L|rcsb pdb:7K2M|rcsb pdb:7K2N|rcsb pdb:7K2O|rcsb pdb:7K2P|rcsb pdb:7K2Q|rcsb pdb:7K2R|rcsb pdb:7K2S|reactome:R-HSA-5689880|reactome:R-HSA-8932339|reactome:R-HSA-8951664|reactome:R-HSA-983168|rcsb pdb:6V6Z interpro:IPR032675 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:3y/KqnUK+5nIyjhOEfkkthmP1OA9606 rogid:ApER1zVhndtaKFQXdWM1QmMe9Lc9606 intact-crc:4F87DA235BCF65DD|rigid:bVCZ9NLKY0r764/CL5vAz/VcNSw false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q14145 uniprotkb:O15067 intact:EBI-751001|uniprotkb:B3KPD5|uniprotkb:Q8WTX1|uniprotkb:Q6LEP0|uniprotkb:Q9BPY9|intact:EBI-28976014|ensembl:ENSP00000171111|ensembl:ENSP00000377245 intact:EBI-1052653|uniprotkb:A6H8V8|ensembl:ENSP00000313490 psi-mi:keap1_human(display_long)|uniprotkb:Cytosolic inhibitor of Nrf2(gene name synonym)|uniprotkb:Kelch-like protein 19(gene name synonym)|uniprotkb:KEAP1(gene name)|psi-mi:KEAP1(display_short)|uniprotkb:INRF2(gene name synonym)|uniprotkb:KIAA0132(gene name synonym)|uniprotkb:KLHL19(gene name synonym) psi-mi:pur4_human(display_long)|uniprotkb:Formylglycinamide ribotide amidotransferase(gene name synonym)|uniprotkb:PFAS(gene name)|psi-mi:PFAS(display_short)|uniprotkb:KIAA0361(gene name synonym)|uniprotkb:Formylglycinamide ribonucleotide amidotransferase(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514586|imex:IM-12079-92 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_036421.2|refseq:NP_987096.1|ensembl:ENSP00000171111|ensembl:ENSP00000377245|refseq:XP_011526754.1|refseq:XP_005260230.1|refseq:XP_005260231.1|dip:DIP-42134N|ensembl:ENSG00000079999(gene)|ensembl:ENST00000171111(transcript)|ensembl:ENST00000393623(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016234"(inclusion body)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030496"(midbody)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0042802"(identical protein binding)|go:"GO:0042994"(cytoplasmic sequestering of transcription factor)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045604"(regulation of epidermal cell differentiation)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0097718"(disordered domain specific binding)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR011705(BTB/Kelch-associated)|interpro:IPR015915(Kelch-type beta propeller)|interpro:IPR017096(Kelch-like protein, gigaxonin)|interpro:IPR030563|mint:Q14145|rcsb pdb:1U6D|rcsb pdb:1ZGK|rcsb pdb:2FLU|rcsb pdb:3VNG|rcsb pdb:3VNH|rcsb pdb:3ZGC|rcsb pdb:3ZGD|rcsb pdb:4CXI|rcsb pdb:4CXJ|rcsb pdb:4CXT|rcsb pdb:4IFJ|rcsb pdb:4IFL|rcsb pdb:4IFN|rcsb pdb:4IN4|rcsb pdb:4IQK|rcsb pdb:4L7B|rcsb pdb:4L7C|rcsb pdb:4L7D|rcsb pdb:4N1B|rcsb pdb:4XMB|rcsb pdb:5DAD|rcsb pdb:5DAF|rcsb pdb:5F72|rcsb pdb:5GIT|rcsb pdb:5NLB|rcsb pdb:5WFL|rcsb pdb:5WFV|rcsb pdb:5WG1|rcsb pdb:5WHL|rcsb pdb:5WHO|rcsb pdb:5WIY|rcsb pdb:5X54|rcsb pdb:6FFM|rcsb pdb:6FMP|rcsb pdb:6FMQ|rcsb pdb:6HWS|rcsb pdb:6LRZ|rcsb pdb:6ROG|rcsb pdb:6SP1|rcsb pdb:6SP4|rcsb pdb:6T7V|rcsb pdb:6T7Z|rcsb pdb:6TG8|rcsb pdb:6TYM|rcsb pdb:6TYP|rcsb pdb:6UF0|rcsb pdb:6W66|rcsb pdb:6W67|rcsb pdb:6W68|rcsb pdb:6W69|rcsb pdb:6WCQ|rcsb pdb:6Z6A|rcsb pdb:7K28|rcsb pdb:7K29|rcsb pdb:7K2A|rcsb pdb:7K2B|rcsb pdb:7K2C|rcsb pdb:7K2D|rcsb pdb:7K2E|rcsb pdb:7K2F|rcsb pdb:7K2G|rcsb pdb:7K2H|rcsb pdb:7K2I|rcsb pdb:7K2J|rcsb pdb:7K2K|rcsb pdb:7K2L|rcsb pdb:7K2M|rcsb pdb:7K2N|rcsb pdb:7K2O|rcsb pdb:7K2P|rcsb pdb:7K2Q|rcsb pdb:7K2R|rcsb pdb:7K2S|reactome:R-HSA-5689880|reactome:R-HSA-8932339|reactome:R-HSA-8951664|reactome:R-HSA-983168|rcsb pdb:6V6Z refseq:NP_036525.1|ensembl:ENSG00000178921(gene)|ensembl:ENST00000314666(transcript)|go:"GO:0004642"(phosphoribosylformylglycinamidine synthase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006189"('de novo' IMP biosynthetic process)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0009168"(purine ribonucleoside monophosphate biosynthetic process)|go:"GO:0042493"|go:"GO:0046872"(metal ion binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097065"(anterior head development)|interpro:IPR010073(Phosphoribosylformylglycinamidine synthase, eukaryotes and proteobacteria)|interpro:IPR010918(AIR synthase related protein, C-terminal)|interpro:IPR029062|interpro:IPR036604|interpro:IPR036676|interpro:IPR036921|interpro:IPR040707|interpro:IPR041609|mint:O15067|reactome:R-HSA-73817 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:3y/KqnUK+5nIyjhOEfkkthmP1OA9606 rogid:e52AyHjHUrLjnoJP+rInkcvfGJk9606 intact-crc:4F87DA235BCF65DD|rigid:bVCZ9NLKY0r764/CL5vAz/VcNSw false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q14145 uniprotkb:Q9H2G2 intact:EBI-751001|uniprotkb:B3KPD5|uniprotkb:Q8WTX1|uniprotkb:Q6LEP0|uniprotkb:Q9BPY9|intact:EBI-28976014|ensembl:ENSP00000171111|ensembl:ENSP00000377245 intact:EBI-1022272|uniprotkb:O00211|uniprotkb:Q6P1Z4|uniprotkb:Q86WU7|uniprotkb:Q86WW1|uniprotkb:Q92603|uniprotkb:Q9NQL0|uniprotkb:Q9NQL1|uniprotkb:D3DRA0|uniprotkb:D3DRA1|ensembl:ENSP00000358770 psi-mi:keap1_human(display_long)|uniprotkb:Cytosolic inhibitor of Nrf2(gene name synonym)|uniprotkb:Kelch-like protein 19(gene name synonym)|uniprotkb:KEAP1(gene name)|psi-mi:KEAP1(display_short)|uniprotkb:INRF2(gene name synonym)|uniprotkb:KIAA0132(gene name synonym)|uniprotkb:KLHL19(gene name synonym) psi-mi:slk_human(display_long)|uniprotkb:STE20-related serine/threonine-protein kinase(gene name synonym)|uniprotkb:Serine/threonine-protein kinase 2(gene name synonym)|uniprotkb:CTCL tumor antigen se20-9(gene name synonym)|uniprotkb:SLK(gene name)|psi-mi:SLK(display_short)|uniprotkb:KIAA0204(gene name synonym)|uniprotkb:STK2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514586|imex:IM-12079-92 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_036421.2|refseq:NP_987096.1|ensembl:ENSP00000171111|ensembl:ENSP00000377245|refseq:XP_011526754.1|refseq:XP_005260230.1|refseq:XP_005260231.1|dip:DIP-42134N|ensembl:ENSG00000079999(gene)|ensembl:ENST00000171111(transcript)|ensembl:ENST00000393623(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016234"(inclusion body)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030496"(midbody)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0042802"(identical protein binding)|go:"GO:0042994"(cytoplasmic sequestering of transcription factor)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045604"(regulation of epidermal cell differentiation)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0097718"(disordered domain specific binding)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR011705(BTB/Kelch-associated)|interpro:IPR015915(Kelch-type beta propeller)|interpro:IPR017096(Kelch-like protein, gigaxonin)|interpro:IPR030563|mint:Q14145|rcsb pdb:1U6D|rcsb pdb:1ZGK|rcsb pdb:2FLU|rcsb pdb:3VNG|rcsb pdb:3VNH|rcsb pdb:3ZGC|rcsb pdb:3ZGD|rcsb pdb:4CXI|rcsb pdb:4CXJ|rcsb pdb:4CXT|rcsb pdb:4IFJ|rcsb pdb:4IFL|rcsb pdb:4IFN|rcsb pdb:4IN4|rcsb pdb:4IQK|rcsb pdb:4L7B|rcsb pdb:4L7C|rcsb pdb:4L7D|rcsb pdb:4N1B|rcsb pdb:4XMB|rcsb pdb:5DAD|rcsb pdb:5DAF|rcsb pdb:5F72|rcsb pdb:5GIT|rcsb pdb:5NLB|rcsb pdb:5WFL|rcsb pdb:5WFV|rcsb pdb:5WG1|rcsb pdb:5WHL|rcsb pdb:5WHO|rcsb pdb:5WIY|rcsb pdb:5X54|rcsb pdb:6FFM|rcsb pdb:6FMP|rcsb pdb:6FMQ|rcsb pdb:6HWS|rcsb pdb:6LRZ|rcsb pdb:6ROG|rcsb pdb:6SP1|rcsb pdb:6SP4|rcsb pdb:6T7V|rcsb pdb:6T7Z|rcsb pdb:6TG8|rcsb pdb:6TYM|rcsb pdb:6TYP|rcsb pdb:6UF0|rcsb pdb:6W66|rcsb pdb:6W67|rcsb pdb:6W68|rcsb pdb:6W69|rcsb pdb:6WCQ|rcsb pdb:6Z6A|rcsb pdb:7K28|rcsb pdb:7K29|rcsb pdb:7K2A|rcsb pdb:7K2B|rcsb pdb:7K2C|rcsb pdb:7K2D|rcsb pdb:7K2E|rcsb pdb:7K2F|rcsb pdb:7K2G|rcsb pdb:7K2H|rcsb pdb:7K2I|rcsb pdb:7K2J|rcsb pdb:7K2K|rcsb pdb:7K2L|rcsb pdb:7K2M|rcsb pdb:7K2N|rcsb pdb:7K2O|rcsb pdb:7K2P|rcsb pdb:7K2Q|rcsb pdb:7K2R|rcsb pdb:7K2S|reactome:R-HSA-5689880|reactome:R-HSA-8932339|reactome:R-HSA-8951664|reactome:R-HSA-983168|rcsb pdb:6V6Z refseq:NP_055535.2|refseq:NP_001291672.1|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0045296"(cadherin binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001943(UvrB/UvrC protein)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR022165|mint:Q9H2G2|rcsb pdb:2J51|rcsb pdb:2JFL|rcsb pdb:2JFM|rcsb pdb:2UV2|rcsb pdb:4USF|rcsb pdb:6HVD|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|ensembl:ENSG00000065613(gene)|ensembl:ENST00000369755(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031252"(cell leading edge) psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:3y/KqnUK+5nIyjhOEfkkthmP1OA9606 rogid:T9Ej6CkWUmqEmPLcptvF2/f1Q+09606 intact-crc:4F87DA235BCF65DD|rigid:bVCZ9NLKY0r764/CL5vAz/VcNSw false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9P2N7 uniprotkb:Q8IVD9 intact:EBI-1996321|uniprotkb:D3DWH6|uniprotkb:Q6P2E3|uniprotkb:Q96QI7|uniprotkb:Q9UDN9|uniprotkb:B3KV78|uniprotkb:B3KWM7|uniprotkb:B7Z3S9|uniprotkb:B7Z5P2|uniprotkb:B7Z802|ensembl:ENSP00000262820 intact:EBI-744342|uniprotkb:Q9BTI3|uniprotkb:Q9H7W9|uniprotkb:Q9UPT4|ensembl:ENSP00000347626 psi-mi:klh13_human(display_long)|uniprotkb:KLHL13(gene name)|psi-mi:KLHL13(display_short)|uniprotkb:BKLHD2(gene name synonym)|uniprotkb:KIAA1309(gene name synonym)|uniprotkb:BTB and kelch domain-containing protein 2(gene name synonym) psi-mi:nudc3_human(display_long)|uniprotkb:NUDCD3(gene name)|psi-mi:NUDCD3(display_short)|uniprotkb:KIAA1068(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514670|imex:IM-12079-42 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001161771.1|refseq:NP_001161772.1|refseq:NP_001161773.1|refseq:NP_001161774.1|refseq:NP_001161775.1|refseq:NP_277030.2|refseq:XP_011529713.1|refseq:XP_016885439.1|interpro:IPR017096(Kelch-like protein, gigaxonin)|reactome:R-HSA-8951664|reactome:R-HSA-983168|ensembl:ENSG00000003096(gene)|ensembl:ENST00000262820(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0007049"(cell cycle)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030496"(midbody)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0051301"(cell division)|go:"GO:0097602"(cullin family protein binding)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR011705(BTB/Kelch-associated)|interpro:IPR015915(Kelch-type beta propeller) refseq:NP_056147.2|ensembl:ENSG00000015676(gene)|ensembl:ENST00000355451(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0006457"(protein folding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0060271"(cilium assembly)|go:"GO:1905793"(protein localization to pericentriolar material)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR025934|interpro:IPR027761|interpro:IPR037898|interpro:IPR037905|rcsb pdb:1WGV|dip:DIP-53643N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:UP21yD93ihtJxCs8xNZ3FUB94tU9606 rogid:T77I/JnekFL6WA/PLnj18OgbFoE9606 intact-crc:AFFE42EC4C7271EA|rigid:5u07/9Zm7qXxwlVk9NSTs13RKS4 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9P2N7 uniprotkb:O95789 intact:EBI-1996321|uniprotkb:D3DWH6|uniprotkb:Q6P2E3|uniprotkb:Q96QI7|uniprotkb:Q9UDN9|uniprotkb:B3KV78|uniprotkb:B3KWM7|uniprotkb:B7Z3S9|uniprotkb:B7Z5P2|uniprotkb:B7Z802|ensembl:ENSP00000262820 intact:EBI-2514645|ensembl:ENSP00000349708|uniprotkb:Q9NWF1|uniprotkb:Q96IY0|uniprotkb:Q69YL4|uniprotkb:Q4G108|uniprotkb:Q32Q23|uniprotkb:B4DRJ6|uniprotkb:Q9P2J4|uniprotkb:Q5SVZ9|uniprotkb:Q5SW00 psi-mi:klh13_human(display_long)|uniprotkb:KLHL13(gene name)|psi-mi:KLHL13(display_short)|uniprotkb:BKLHD2(gene name synonym)|uniprotkb:KIAA1309(gene name synonym)|uniprotkb:BTB and kelch domain-containing protein 2(gene name synonym) psi-mi:zmym6_human(display_long)|uniprotkb:ZMYM6(gene name)|psi-mi:ZMYM6(display_short)|uniprotkb:KIAA1353(gene name synonym)|uniprotkb:ZNF258(gene name synonym)|uniprotkb:Zinc finger protein 258(gene name synonym)|uniprotkb:Buster2(gene name synonym)|uniprotkb:Transposon-derived Buster2 transposase-like protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514670|imex:IM-12079-42 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001161771.1|refseq:NP_001161772.1|refseq:NP_001161773.1|refseq:NP_001161774.1|refseq:NP_001161775.1|refseq:NP_277030.2|refseq:XP_011529713.1|refseq:XP_016885439.1|interpro:IPR017096(Kelch-like protein, gigaxonin)|reactome:R-HSA-8951664|reactome:R-HSA-983168|ensembl:ENSG00000003096(gene)|ensembl:ENST00000262820(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0007049"(cell cycle)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030496"(midbody)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0051301"(cell division)|go:"GO:0097602"(cullin family protein binding)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR011705(BTB/Kelch-associated)|interpro:IPR015915(Kelch-type beta propeller) ensembl:ENSG00000163867(gene)|ensembl:ENST00000357182(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0022604"(regulation of cell morphogenesis)|interpro:IPR010507(Zinc finger, MYM-type)|interpro:IPR011017(TRASH)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR025398|refseq:NP_009098.3 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:UP21yD93ihtJxCs8xNZ3FUB94tU9606 rogid:+g4Q8I50GP6Rhbptsd3A0ZMbuko9606 intact-crc:AFFE42EC4C7271EA|rigid:5u07/9Zm7qXxwlVk9NSTs13RKS4 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9P2N7 uniprotkb:Q13257 intact:EBI-1996321|uniprotkb:D3DWH6|uniprotkb:Q6P2E3|uniprotkb:Q96QI7|uniprotkb:Q9UDN9|uniprotkb:B3KV78|uniprotkb:B3KWM7|uniprotkb:B7Z3S9|uniprotkb:B7Z5P2|uniprotkb:B7Z802|ensembl:ENSP00000262820 intact:EBI-78203|intact:EBI-28969404|ensembl:ENSP00000296509|uniprotkb:Q53F56|uniprotkb:Q548X9|uniprotkb:Q6IRW7|uniprotkb:Q8IZX3 psi-mi:klh13_human(display_long)|uniprotkb:KLHL13(gene name)|psi-mi:KLHL13(display_short)|uniprotkb:BKLHD2(gene name synonym)|uniprotkb:KIAA1309(gene name synonym)|uniprotkb:BTB and kelch domain-containing protein 2(gene name synonym) psi-mi:md2l1_human(display_long)|uniprotkb:MAD2L1(gene name)|psi-mi:MAD2L1(display_short)|uniprotkb:MAD2(gene name synonym)|uniprotkb:Mitotic arrest deficient 2-like protein 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514670|imex:IM-12079-42 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001161771.1|refseq:NP_001161772.1|refseq:NP_001161773.1|refseq:NP_001161774.1|refseq:NP_001161775.1|refseq:NP_277030.2|refseq:XP_011529713.1|refseq:XP_016885439.1|interpro:IPR017096(Kelch-like protein, gigaxonin)|reactome:R-HSA-8951664|reactome:R-HSA-983168|ensembl:ENSG00000003096(gene)|ensembl:ENST00000262820(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0007049"(cell cycle)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030496"(midbody)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0051301"(cell division)|go:"GO:0097602"(cullin family protein binding)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR011705(BTB/Kelch-associated)|interpro:IPR015915(Kelch-type beta propeller) ensembl:ENSG00000164109(gene)|ensembl:ENST00000296509(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000776"(kinetochore)|go:"GO:0000922"(spindle pole)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044615"(nuclear pore nuclear basket)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051301"(cell division)|go:"GO:0051660"(establishment of centrosome localization)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090267"(positive regulation of mitotic cell cycle spindle assembly checkpoint)|go:"GO:1904667"(negative regulation of ubiquitin protein ligase activity)|interpro:IPR003511(DNA-binding HORMA)|interpro:IPR036570|mint:Q13257|rcsb pdb:1DUJ|rcsb pdb:1GO4|rcsb pdb:1S2H|rcsb pdb:1KLQ|rcsb pdb:2QYF|rcsb pdb:2V64|rcsb pdb:2VFX|rcsb pdb:3GMH|rcsb pdb:5KHU|rcsb pdb:5LCW|rcsb pdb:6F0X|rcsb pdb:6TLJ|reactome:R-HSA-141405|reactome:R-HSA-141430|reactome:R-HSA-141444|reactome:R-HSA-174184|reactome:R-HSA-176409|reactome:R-HSA-179409|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|ensembl:ENSP00000296509|ensembl:ENST00000333047|ensembl:ENSP00000332295|refseq:NP_002349.1|dip:DIP-29653N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:UP21yD93ihtJxCs8xNZ3FUB94tU9606 rogid:FyL1tmJllOZ4gQvwWb96aV9PMFw9606 intact-crc:AFFE42EC4C7271EA|rigid:5u07/9Zm7qXxwlVk9NSTs13RKS4 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9P2N7 uniprotkb:Q9BT78 intact:EBI-1996321|uniprotkb:D3DWH6|uniprotkb:Q6P2E3|uniprotkb:Q96QI7|uniprotkb:Q9UDN9|uniprotkb:B3KV78|uniprotkb:B3KWM7|uniprotkb:B7Z3S9|uniprotkb:B7Z5P2|uniprotkb:B7Z802|ensembl:ENSP00000262820 intact:EBI-742413|uniprotkb:Q561W7|uniprotkb:Q9NW31|uniprotkb:Q9Y677|uniprotkb:B3KN88|ensembl:ENSP00000264389|uniprotkb:B3KST5 psi-mi:klh13_human(display_long)|uniprotkb:KLHL13(gene name)|psi-mi:KLHL13(display_short)|uniprotkb:BKLHD2(gene name synonym)|uniprotkb:KIAA1309(gene name synonym)|uniprotkb:BTB and kelch domain-containing protein 2(gene name synonym) psi-mi:csn4_human(display_long)|uniprotkb:COPS4(gene name)|psi-mi:COPS4(display_short)|uniprotkb:CSN4(gene name synonym)|uniprotkb:JAB1-containing signalosome subunit 4(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514670|imex:IM-12079-42 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001161771.1|refseq:NP_001161772.1|refseq:NP_001161773.1|refseq:NP_001161774.1|refseq:NP_001161775.1|refseq:NP_277030.2|refseq:XP_011529713.1|refseq:XP_016885439.1|interpro:IPR017096(Kelch-like protein, gigaxonin)|reactome:R-HSA-8951664|reactome:R-HSA-983168|ensembl:ENSG00000003096(gene)|ensembl:ENST00000262820(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0007049"(cell cycle)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030496"(midbody)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0051301"(cell division)|go:"GO:0097602"(cullin family protein binding)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR011705(BTB/Kelch-associated)|interpro:IPR015915(Kelch-type beta propeller) ensembl:ENSG00000138663(gene)|refseq:NP_057213.2|refseq:NP_001244935.1|go:"GO:0016607"(nuclear speck)|go:"GO:0019784"(NEDD8-specific protease activity)|go:"GO:0030054"(cell junction)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR036388|interpro:IPR036390|interpro:IPR037754|interpro:IPR040134|interpro:IPR041406|mint:Q9BT78|rcsb pdb:4D0P|rcsb pdb:4D10|rcsb pdb:4D18|rcsb pdb:4WSN|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|rcsb pdb:6R7N|reactome:R-HSA-5696394|reactome:R-HSA-6781823|reactome:R-HSA-8856825|reactome:R-HSA-8951664|reactome:R-HSA-9013422|ensembl:ENST00000264389(transcript)|go:"GO:0000338"(protein deneddylation)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008180"(COP9 signalosome)|refseq:NP_001317656.1|dip:DIP-34516N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:UP21yD93ihtJxCs8xNZ3FUB94tU9606 rogid:onrZiPzG+bZvycmpDTZMtkPzCfQ9606 intact-crc:AFFE42EC4C7271EA|rigid:5u07/9Zm7qXxwlVk9NSTs13RKS4 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9P2N7 uniprotkb:Q9P2J3 intact:EBI-1996321|uniprotkb:D3DWH6|uniprotkb:Q6P2E3|uniprotkb:Q96QI7|uniprotkb:Q9UDN9|uniprotkb:B3KV78|uniprotkb:B3KWM7|uniprotkb:B7Z3S9|uniprotkb:B7Z5P2|uniprotkb:B7Z802|ensembl:ENSP00000262820 intact:EBI-2510152|ensembl:ENSP00000351933|uniprotkb:Q8TCQ2 psi-mi:klh13_human(display_long)|uniprotkb:KLHL13(gene name)|psi-mi:KLHL13(display_short)|uniprotkb:BKLHD2(gene name synonym)|uniprotkb:KIAA1309(gene name synonym)|uniprotkb:BTB and kelch domain-containing protein 2(gene name synonym) psi-mi:klhl9_human(display_long)|uniprotkb:KLHL9(gene name)|psi-mi:KLHL9(display_short)|uniprotkb:KIAA1354(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514670|imex:IM-12079-42 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001161771.1|refseq:NP_001161772.1|refseq:NP_001161773.1|refseq:NP_001161774.1|refseq:NP_001161775.1|refseq:NP_277030.2|refseq:XP_011529713.1|refseq:XP_016885439.1|interpro:IPR017096(Kelch-like protein, gigaxonin)|reactome:R-HSA-8951664|reactome:R-HSA-983168|ensembl:ENSG00000003096(gene)|ensembl:ENST00000262820(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0007049"(cell cycle)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030496"(midbody)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0051301"(cell division)|go:"GO:0097602"(cullin family protein binding)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR011705(BTB/Kelch-associated)|interpro:IPR015915(Kelch-type beta propeller) ensembl:ENSG00000198642(gene)|ensembl:ENST00000359039(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0007049"(cell cycle)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030496"(midbody)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0051301"(cell division)|go:"GO:0097602"(cullin family protein binding)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR011705(BTB/Kelch-associated)|interpro:IPR015915(Kelch-type beta propeller)|interpro:IPR017096(Kelch-like protein, gigaxonin)|reactome:R-HSA-8951664|reactome:R-HSA-983168|refseq:NP_061335.1|dip:DIP-53514N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:UP21yD93ihtJxCs8xNZ3FUB94tU9606 rogid:BBlUawWo6f4qKrbRHeZp87E+DTo9606 intact-crc:AFFE42EC4C7271EA|rigid:5u07/9Zm7qXxwlVk9NSTs13RKS4 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9P2N7 uniprotkb:P51784 intact:EBI-1996321|uniprotkb:D3DWH6|uniprotkb:Q6P2E3|uniprotkb:Q96QI7|uniprotkb:Q9UDN9|uniprotkb:B3KV78|uniprotkb:B3KWM7|uniprotkb:B7Z3S9|uniprotkb:B7Z5P2|uniprotkb:B7Z802|ensembl:ENSP00000262820 intact:EBI-306876|intact:EBI-1058416|uniprotkb:Q8IUG6|uniprotkb:Q9BWE1|uniprotkb:B2RTX1|ensembl:ENSP00000218348 psi-mi:klh13_human(display_long)|uniprotkb:KLHL13(gene name)|psi-mi:KLHL13(display_short)|uniprotkb:BKLHD2(gene name synonym)|uniprotkb:KIAA1309(gene name synonym)|uniprotkb:BTB and kelch domain-containing protein 2(gene name synonym) psi-mi:ubp11_human(display_long)|uniprotkb:USP11(gene name)|psi-mi:USP11(display_short)|uniprotkb:UHX1(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 11(gene name synonym)|uniprotkb:Deubiquitinating enzyme 11(gene name synonym)|uniprotkb:Ubiquitin thioesterase 11(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514670|imex:IM-12079-42 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001161771.1|refseq:NP_001161772.1|refseq:NP_001161773.1|refseq:NP_001161774.1|refseq:NP_001161775.1|refseq:NP_277030.2|refseq:XP_011529713.1|refseq:XP_016885439.1|interpro:IPR017096(Kelch-like protein, gigaxonin)|reactome:R-HSA-8951664|reactome:R-HSA-983168|ensembl:ENSG00000003096(gene)|ensembl:ENST00000262820(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0007049"(cell cycle)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030496"(midbody)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0051301"(cell division)|go:"GO:0097602"(cullin family protein binding)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR011705(BTB/Kelch-associated)|interpro:IPR015915(Kelch-type beta propeller) ensembl:ENSG00000102226(gene)|ensembl:ENST00000218348(transcript)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR018200|interpro:IPR028135|interpro:IPR028889|interpro:IPR029346|interpro:IPR035927|interpro:IPR038765|mint:P51784|rcsb pdb:4MEL|rcsb pdb:5OK6|reactome:R-HSA-390471|reactome:R-HSA-5689880|refseq:NP_004642.2|refseq:XP_011542290.1|refseq:XP_005272731.1|dip:DIP-27567N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:UP21yD93ihtJxCs8xNZ3FUB94tU9606 rogid:OSJLLFBf1ofw8SC01p2iiIM1oJo9606 intact-crc:AFFE42EC4C7271EA|rigid:5u07/9Zm7qXxwlVk9NSTs13RKS4 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9P2N7 uniprotkb:Q5VZL5 intact:EBI-1996321|uniprotkb:D3DWH6|uniprotkb:Q6P2E3|uniprotkb:Q96QI7|uniprotkb:Q9UDN9|uniprotkb:B3KV78|uniprotkb:B3KWM7|uniprotkb:B7Z3S9|uniprotkb:B7Z5P2|uniprotkb:B7Z802|ensembl:ENSP00000262820 intact:EBI-2514659|intact:EBI-28984130|ensembl:ENSP00000322915|uniprotkb:A0JP19|uniprotkb:O43308|uniprotkb:A0JP20|uniprotkb:Q5T5E2|uniprotkb:Q7L3Q4|uniprotkb:Q5T5E1|intact:EBI-2556245 psi-mi:klh13_human(display_long)|uniprotkb:KLHL13(gene name)|psi-mi:KLHL13(display_short)|uniprotkb:BKLHD2(gene name synonym)|uniprotkb:KIAA1309(gene name synonym)|uniprotkb:BTB and kelch domain-containing protein 2(gene name synonym) psi-mi:zmym4_human(display_long)|uniprotkb:ZMYM4(gene name)|psi-mi:ZMYM4(display_short)|uniprotkb:KIAA0425(gene name synonym)|uniprotkb:ZNF262(gene name synonym)|uniprotkb:Zinc finger protein 262(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514670|imex:IM-12079-42 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001161771.1|refseq:NP_001161772.1|refseq:NP_001161773.1|refseq:NP_001161774.1|refseq:NP_001161775.1|refseq:NP_277030.2|refseq:XP_011529713.1|refseq:XP_016885439.1|interpro:IPR017096(Kelch-like protein, gigaxonin)|reactome:R-HSA-8951664|reactome:R-HSA-983168|ensembl:ENSG00000003096(gene)|ensembl:ENST00000262820(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0007049"(cell cycle)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030496"(midbody)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0051301"(cell division)|go:"GO:0097602"(cullin family protein binding)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR011705(BTB/Kelch-associated)|interpro:IPR015915(Kelch-type beta propeller) ensembl:ENSG00000146463(gene)|ensembl:ENST00000314607(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0022604"(regulation of cell morphogenesis)|interpro:IPR010507(Zinc finger, MYM-type)|interpro:IPR011017(TRASH)|interpro:IPR021893|refseq:XP_016858292.1|refseq:XP_016858293.1|refseq:XP_011540725.1|refseq:XP_011540727.1|refseq:NP_005086.2|ensembl:ENSP00000322915|refseq:XP_005271388.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:UP21yD93ihtJxCs8xNZ3FUB94tU9606 rogid:jc8YwR+37J3uD08cXiUnOA2hHEI9606 intact-crc:AFFE42EC4C7271EA|rigid:5u07/9Zm7qXxwlVk9NSTs13RKS4 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9P2N7 uniprotkb:P61201 intact:EBI-1996321|uniprotkb:D3DWH6|uniprotkb:Q6P2E3|uniprotkb:Q96QI7|uniprotkb:Q9UDN9|uniprotkb:B3KV78|uniprotkb:B3KWM7|uniprotkb:B7Z3S9|uniprotkb:B7Z5P2|uniprotkb:B7Z802|ensembl:ENSP00000262820 intact:EBI-1050386|uniprotkb:O88950|uniprotkb:Q15647|uniprotkb:Q6FGP4|uniprotkb:Q9BY54|uniprotkb:Q9R249|uniprotkb:Q9UNI2|uniprotkb:Q9UNQ5|ensembl:ENSP00000373553 psi-mi:klh13_human(display_long)|uniprotkb:KLHL13(gene name)|psi-mi:KLHL13(display_short)|uniprotkb:BKLHD2(gene name synonym)|uniprotkb:KIAA1309(gene name synonym)|uniprotkb:BTB and kelch domain-containing protein 2(gene name synonym) psi-mi:csn2_human(display_long)|uniprotkb:JAB1-containing signalosome subunit 2(gene name synonym)|uniprotkb:Thyroid receptor-interacting protein 15(gene name synonym)|uniprotkb:Alien homolog(gene name synonym)|uniprotkb:COPS2(gene name)|psi-mi:COPS2(display_short)|uniprotkb:CSN2(gene name synonym)|uniprotkb:TRIP15(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514670|imex:IM-12079-42 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001161771.1|refseq:NP_001161772.1|refseq:NP_001161773.1|refseq:NP_001161774.1|refseq:NP_001161775.1|refseq:NP_277030.2|refseq:XP_011529713.1|refseq:XP_016885439.1|interpro:IPR017096(Kelch-like protein, gigaxonin)|reactome:R-HSA-8951664|reactome:R-HSA-983168|ensembl:ENSG00000003096(gene)|ensembl:ENST00000262820(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0007049"(cell cycle)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030496"(midbody)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0051301"(cell division)|go:"GO:0097602"(cullin family protein binding)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR011705(BTB/Kelch-associated)|interpro:IPR015915(Kelch-type beta propeller) refseq:NP_001137359.1|refseq:NP_004227.1|ensembl:ENSG00000166200(gene)|ensembl:ENST00000388901(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000338"(protein deneddylation)|go:"GO:0001833"(inner cell mass cell proliferation)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0030182"(neuron differentiation)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:1903507"(negative regulation of nucleic acid-templated transcription)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR036390|interpro:IPR037750|mint:P61201|rcsb pdb:4D10|rcsb pdb:4D18|rcsb pdb:4WSN|rcsb pdb:6A73|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|rcsb pdb:6R7N|reactome:R-HSA-5696394|reactome:R-HSA-6781823|reactome:R-HSA-8856825|reactome:R-HSA-8951664|reactome:R-HSA-9013422|dip:DIP-42076N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:UP21yD93ihtJxCs8xNZ3FUB94tU9606 rogid:MrlEHktIBvvcQux7Z7kqYJYgbbs9606 intact-crc:AFFE42EC4C7271EA|rigid:5u07/9Zm7qXxwlVk9NSTs13RKS4 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9P2N7 uniprotkb:Q53GT1 intact:EBI-1996321|uniprotkb:D3DWH6|uniprotkb:Q6P2E3|uniprotkb:Q96QI7|uniprotkb:Q9UDN9|uniprotkb:B3KV78|uniprotkb:B3KWM7|uniprotkb:B7Z3S9|uniprotkb:B7Z5P2|uniprotkb:B7Z802|ensembl:ENSP00000262820 intact:EBI-1996072|uniprotkb:D3DX30|uniprotkb:Q96B68|uniprotkb:Q96KC6|uniprotkb:A8MTV3|uniprotkb:A8K3Q4|ensembl:ENSP00000331682|uniprotkb:B7Z2G1 psi-mi:klh13_human(display_long)|uniprotkb:KLHL13(gene name)|psi-mi:KLHL13(display_short)|uniprotkb:BKLHD2(gene name synonym)|uniprotkb:KIAA1309(gene name synonym)|uniprotkb:BTB and kelch domain-containing protein 2(gene name synonym) psi-mi:klh22_human(display_long)|uniprotkb:KLHL22(gene name)|psi-mi:KLHL22(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514670|imex:IM-12079-42 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001161771.1|refseq:NP_001161772.1|refseq:NP_001161773.1|refseq:NP_001161774.1|refseq:NP_001161775.1|refseq:NP_277030.2|refseq:XP_011529713.1|refseq:XP_016885439.1|interpro:IPR017096(Kelch-like protein, gigaxonin)|reactome:R-HSA-8951664|reactome:R-HSA-983168|ensembl:ENSG00000003096(gene)|ensembl:ENST00000262820(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0007049"(cell cycle)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030496"(midbody)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0051301"(cell division)|go:"GO:0097602"(cullin family protein binding)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR011705(BTB/Kelch-associated)|interpro:IPR015915(Kelch-type beta propeller) refseq:NP_116164.2|refseq:XP_016884510.1|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005813"(centrosome)|go:"GO:0005827"(polar microtubule)|go:"GO:0005829"(cytosol)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0007094"(mitotic spindle assembly checkpoint signaling)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045171"(intercellular bridge)|go:"GO:0051301"(cell division)|go:"GO:0071233"(cellular response to leucine)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0072686"(mitotic spindle)|go:"GO:1904263"(positive regulation of TORC1 signaling)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR011705(BTB/Kelch-associated)|interpro:IPR015915(Kelch-type beta propeller)|interpro:IPR017096(Kelch-like protein, gigaxonin)|interpro:IPR030575|mint:Q53GT1|reactome:R-HSA-8951664|reactome:R-HSA-983168|ensembl:ENSG00000099910(gene)|ensembl:ENST00000328879(transcript) psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:UP21yD93ihtJxCs8xNZ3FUB94tU9606 rogid:EC3vXSWYpde+ZCa6lm86DF+sfM89606 intact-crc:AFFE42EC4C7271EA|rigid:5u07/9Zm7qXxwlVk9NSTs13RKS4 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q7KZI7 uniprotkb:O75271 intact:EBI-516560|uniprotkb:Q15449|uniprotkb:Q15524|uniprotkb:Q5XGA3|uniprotkb:Q68A18|uniprotkb:Q96HB3|uniprotkb:Q96RG0|ensembl:ENSP00000385751 intact:EBI-2512144 psi-mi:mark2_human(display_long)|uniprotkb:MAP/microtubule affinity-regulating kinase 2(gene name synonym)|uniprotkb:ELKL motif kinase 1(gene name synonym)|uniprotkb:PAR1 homolog(gene name synonym)|uniprotkb:MARK2(gene name)|psi-mi:MARK2(display_short)|uniprotkb:EMK1(gene name synonym)|uniprotkb:PAR1 homolog b(gene name synonym) psi-mi:o75271_human(display_long) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514724|imex:IM-12079-93 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001034558.2|refseq:NP_001156768.1|refseq:NP_001156769.1|refseq:NP_004945.4|refseq:NP_059672.2|dip:DIP-31321N|ensembl:ENSG00000072518(gene)|ensembl:ENST00000402010(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0001764"(neuron migration)|go:"GO:0003723"(RNA binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008289"(lipid binding)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0045296"(cadherin binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048156"(tau protein binding)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030425"(dendrite)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0051646"(mitochondrion localization)|go:"GO:0061564"(axon development)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0071963"(establishment or maintenance of cell polarity regulating cell shape)|go:"GO:0097427"(microtubule bundle)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1904526"(regulation of microtubule binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001772(Kinase-associated KA1)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028375|mint:Q7KZI7|rcsb pdb:3IEC|rcsb pdb:5EAK|rcsb pdb:5KZ7|rcsb pdb:5KZ8 go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote) psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/09/18 rogid:yfUqSCu4bgkncBd6hRRg5pKkArc9606 rogid:KUEiJMN0cWYUN+uYdGWh2WZQw4g9606 intact-crc:8CC685E772E6CABB|rigid:Z4RZV/2i2psYZ5ttHMwfpjdkVOo false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q7KZI7 uniprotkb:Q5JY77 intact:EBI-516560|uniprotkb:Q15449|uniprotkb:Q15524|uniprotkb:Q5XGA3|uniprotkb:Q68A18|uniprotkb:Q96HB3|uniprotkb:Q96RG0|ensembl:ENSP00000385751 intact:EBI-2514717|ensembl:ENSP00000355146|ensembl:ENSP00000393691|ensembl:ENSP00000409420|ensembl:ENSP00000445683|ensembl:ENSP00000498934|uniprotkb:Q96LA1|uniprotkb:O43168 psi-mi:mark2_human(display_long)|uniprotkb:MAP/microtubule affinity-regulating kinase 2(gene name synonym)|uniprotkb:ELKL motif kinase 1(gene name synonym)|uniprotkb:PAR1 homolog(gene name synonym)|uniprotkb:MARK2(gene name)|psi-mi:MARK2(display_short)|uniprotkb:EMK1(gene name synonym)|uniprotkb:PAR1 homolog b(gene name synonym) psi-mi:gasp1_human(display_long)|uniprotkb:GPRASP1(gene name)|psi-mi:GPRASP1(display_short)|uniprotkb:GASP(gene name synonym)|uniprotkb:KIAA0443(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514724|imex:IM-12079-93 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001034558.2|refseq:NP_001156768.1|refseq:NP_001156769.1|refseq:NP_004945.4|refseq:NP_059672.2|dip:DIP-31321N|ensembl:ENSG00000072518(gene)|ensembl:ENST00000402010(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0001764"(neuron migration)|go:"GO:0003723"(RNA binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008289"(lipid binding)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0045296"(cadherin binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048156"(tau protein binding)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030425"(dendrite)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0051646"(mitochondrion localization)|go:"GO:0061564"(axon development)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0071963"(establishment or maintenance of cell polarity regulating cell shape)|go:"GO:0097427"(microtubule bundle)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1904526"(regulation of microtubule binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001772(Kinase-associated KA1)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028375|mint:Q7KZI7|rcsb pdb:3IEC|rcsb pdb:5EAK|rcsb pdb:5KZ7|rcsb pdb:5KZ8 ensembl:ENSG00000198932(gene)|ensembl:ENST00000361600(transcript)|ensembl:ENST00000415986(transcript)|ensembl:ENST00000444152(transcript)|ensembl:ENST00000537097(transcript)|ensembl:ENST00000652542(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:1990172"(G protein-coupled receptor catabolic process)|interpro:IPR006911(Protein of unknown function DUF634)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR043374|refseq:XP_016885470.1|refseq:XP_016885471.1|refseq:NP_001092880.1|refseq:NP_001092881.1|refseq:NP_001171656.1|refseq:NP_055525.3|ensembl:ENSP00000355146|ensembl:ENSP00000393691|ensembl:ENSP00000409420|ensembl:ENSP00000445683|ensembl:ENSP00000498934 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/09/18 rogid:yfUqSCu4bgkncBd6hRRg5pKkArc9606 rogid:hV+EvmQTl209eBHMYEB0Pq21jYo9606 intact-crc:8CC685E772E6CABB|rigid:Z4RZV/2i2psYZ5ttHMwfpjdkVOo false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q7KZI7 uniprotkb:P04066 intact:EBI-516560|uniprotkb:Q15449|uniprotkb:Q15524|uniprotkb:Q5XGA3|uniprotkb:Q68A18|uniprotkb:Q96HB3|uniprotkb:Q96RG0|ensembl:ENSP00000385751 intact:EBI-2512153|ensembl:ENSP00000363603|uniprotkb:Q14335|uniprotkb:Q8NAC2|uniprotkb:Q3LID0|uniprotkb:Q14334|uniprotkb:B2RBG3 psi-mi:mark2_human(display_long)|uniprotkb:MAP/microtubule affinity-regulating kinase 2(gene name synonym)|uniprotkb:ELKL motif kinase 1(gene name synonym)|uniprotkb:PAR1 homolog(gene name synonym)|uniprotkb:MARK2(gene name)|psi-mi:MARK2(display_short)|uniprotkb:EMK1(gene name synonym)|uniprotkb:PAR1 homolog b(gene name synonym) psi-mi:fuco_human(display_long)|uniprotkb:FUCA1(gene name)|psi-mi:FUCA1(display_short)|uniprotkb:Alpha-L-fucoside fucohydrolase 1(gene name synonym)|uniprotkb:Alpha-L-fucosidase I(gene name synonym)|uniprotkb:Nbla10230(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514724|imex:IM-12079-93 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001034558.2|refseq:NP_001156768.1|refseq:NP_001156769.1|refseq:NP_004945.4|refseq:NP_059672.2|dip:DIP-31321N|ensembl:ENSG00000072518(gene)|ensembl:ENST00000402010(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0001764"(neuron migration)|go:"GO:0003723"(RNA binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008289"(lipid binding)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0045296"(cadherin binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048156"(tau protein binding)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030425"(dendrite)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0051646"(mitochondrion localization)|go:"GO:0061564"(axon development)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0071963"(establishment or maintenance of cell polarity regulating cell shape)|go:"GO:0097427"(microtubule bundle)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1904526"(regulation of microtubule binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001772(Kinase-associated KA1)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028375|mint:Q7KZI7|rcsb pdb:3IEC|rcsb pdb:5EAK|rcsb pdb:5KZ7|rcsb pdb:5KZ8 ensembl:ENSG00000179163(gene)|ensembl:ENST00000374479(transcript)|go:"GO:0004560"(alpha-L-fucosidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0006004"(fucose metabolic process)|go:"GO:0006027"(glycosaminoglycan catabolic process)|go:"GO:0016139"(glycoside catabolic process)|go:"GO:0019377"(glycolipid catabolic process)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000933("Glycoside hydrolase, family 29 (alpha-L-fucosidase)")|interpro:IPR013780(Glycosyl hydrolase, family 13, all-beta)|interpro:IPR016286(Alpha-L-fucosidase)|interpro:IPR017853(Glycoside hydrolase, catalytic core)|interpro:IPR018526|interpro:IPR028755|interpro:IPR031919|mint:P04066|reactome:R-HSA-6798695|reactome:R-HSA-975578|refseq:NP_000138.2 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/09/18 rogid:yfUqSCu4bgkncBd6hRRg5pKkArc9606 rogid:hzGxBObvRAGMJxL+I9shJUo+nLg9606 intact-crc:8CC685E772E6CABB|rigid:Z4RZV/2i2psYZ5ttHMwfpjdkVOo false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q7KZI7 uniprotkb:Q9Y4J8 intact:EBI-516560|uniprotkb:Q15449|uniprotkb:Q15524|uniprotkb:Q5XGA3|uniprotkb:Q68A18|uniprotkb:Q96HB3|uniprotkb:Q96RG0|ensembl:ENSP00000385751 intact:EBI-949471|ensembl:ENSP00000382064|uniprotkb:O15332|uniprotkb:O15333|uniprotkb:O75697|uniprotkb:Q13197|uniprotkb:Q13198|uniprotkb:Q13199|uniprotkb:Q13498|uniprotkb:Q13499|uniprotkb:Q13500|uniprotkb:A8MUY4|uniprotkb:A8K541|uniprotkb:M0QYX6|uniprotkb:A8MSZ0|uniprotkb:Q9BS59|uniprotkb:B4DIU8|uniprotkb:B4DIR0|uniprotkb:B4DGS6|uniprotkb:M0R397|uniprotkb:Q59GK7 psi-mi:mark2_human(display_long)|uniprotkb:MAP/microtubule affinity-regulating kinase 2(gene name synonym)|uniprotkb:ELKL motif kinase 1(gene name synonym)|uniprotkb:PAR1 homolog(gene name synonym)|uniprotkb:MARK2(gene name)|psi-mi:MARK2(display_short)|uniprotkb:EMK1(gene name synonym)|uniprotkb:PAR1 homolog b(gene name synonym) psi-mi:dtna_human(display_long)|uniprotkb:Alpha-dystrobrevin(gene name synonym)|uniprotkb:Dystrophin-related protein 3(gene name synonym)|uniprotkb:DTNA(gene name)|psi-mi:DTNA(display_short)|uniprotkb:DRP3(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514724|imex:IM-12079-93 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001034558.2|refseq:NP_001156768.1|refseq:NP_001156769.1|refseq:NP_004945.4|refseq:NP_059672.2|dip:DIP-31321N|ensembl:ENSG00000072518(gene)|ensembl:ENST00000402010(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0001764"(neuron migration)|go:"GO:0003723"(RNA binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008289"(lipid binding)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0045296"(cadherin binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048156"(tau protein binding)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030425"(dendrite)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0051646"(mitochondrion localization)|go:"GO:0061564"(axon development)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0071963"(establishment or maintenance of cell polarity regulating cell shape)|go:"GO:0097427"(microtubule bundle)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1904526"(regulation of microtubule binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001772(Kinase-associated KA1)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028375|mint:Q7KZI7|rcsb pdb:3IEC|rcsb pdb:5EAK|rcsb pdb:5KZ7|rcsb pdb:5KZ8 ensembl:ENSG00000134769(gene)|ensembl:ENST00000399113(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006941"(striated muscle contraction)|go:"GO:0007165"(signal transduction)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007274"(neuromuscular synaptic transmission)|go:"GO:0008270"(zinc ion binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030054"(cell junction)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030424"(axon)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042383"(sarcolemma)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045202"(synapse)|go:"GO:0099536"(synaptic signaling)|interpro:IPR011992(EF-Hand type)|interpro:IPR015153(EF-hand, region 1)|interpro:IPR015154(EF-hand, region 2)|interpro:IPR017432(Distrobrevin)|interpro:IPR043145|mint:Q9Y4J8|rcsb pdb:2E5R|interpro:IPR000433(Zinc finger, ZZ-type)|refseq:NP_001185873.1|refseq:NP_001381.2|refseq:NP_001382.2|refseq:NP_001383.2|refseq:NP_116757.2|refseq:NP_116760.2|refseq:NP_116761.2|refseq:NP_116762.2|refseq:NP_116763.1|refseq:XP_011524155.1|refseq:NP_001121647.1|refseq:NP_001185867.1|refseq:NP_001185868.1|refseq:NP_001185871.1|refseq:NP_001185869.1|refseq:NP_001185874.1|refseq:NP_001185870.1|refseq:XP_016881066.1|refseq:XP_016881073.1|refseq:XP_016881076.1|refseq:XP_016881077.1|refseq:XP_016881078.1|refseq:XP_016881079.1|refseq:XP_016881080.1|refseq:XP_016881089.1|refseq:XP_016881090.1|refseq:XP_016881091.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/09/18 rogid:yfUqSCu4bgkncBd6hRRg5pKkArc9606 rogid:9HaDKLthoXmwdYDzbEer3CRN3O09606 intact-crc:8CC685E772E6CABB|rigid:Z4RZV/2i2psYZ5ttHMwfpjdkVOo false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q7KZI7 uniprotkb:Q5SZL2 intact:EBI-516560|uniprotkb:Q15449|uniprotkb:Q15524|uniprotkb:Q5XGA3|uniprotkb:Q68A18|uniprotkb:Q96HB3|uniprotkb:Q96RG0|ensembl:ENSP00000385751 intact:EBI-2514702|ensembl:ENSP00000357477|uniprotkb:Q2TAM2|uniprotkb:Q9H289|uniprotkb:A1A4E1|uniprotkb:A2IDE5|uniprotkb:Q5T323|uniprotkb:Q7Z5K7|uniprotkb:A2A3P2|uniprotkb:F8W6J2|uniprotkb:G3V0H3 psi-mi:mark2_human(display_long)|uniprotkb:MAP/microtubule affinity-regulating kinase 2(gene name synonym)|uniprotkb:ELKL motif kinase 1(gene name synonym)|uniprotkb:PAR1 homolog(gene name synonym)|uniprotkb:MARK2(gene name)|psi-mi:MARK2(display_short)|uniprotkb:EMK1(gene name synonym)|uniprotkb:PAR1 homolog b(gene name synonym) psi-mi:ce85l_human(display_long)|uniprotkb:CEP85L(gene name)|psi-mi:CEP85L(display_short)|uniprotkb:C6orf204(gene name synonym)|uniprotkb:Serologically defined breast cancer antigen NY-BR-15(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514724|imex:IM-12079-93 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001034558.2|refseq:NP_001156768.1|refseq:NP_001156769.1|refseq:NP_004945.4|refseq:NP_059672.2|dip:DIP-31321N|ensembl:ENSG00000072518(gene)|ensembl:ENST00000402010(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0001764"(neuron migration)|go:"GO:0003723"(RNA binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008289"(lipid binding)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0045296"(cadherin binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048156"(tau protein binding)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030425"(dendrite)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0051646"(mitochondrion localization)|go:"GO:0061564"(axon development)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0071963"(establishment or maintenance of cell polarity regulating cell shape)|go:"GO:0097427"(microtubule bundle)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1904526"(regulation of microtubule binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001772(Kinase-associated KA1)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028375|mint:Q7KZI7|rcsb pdb:3IEC|rcsb pdb:5EAK|rcsb pdb:5KZ7|rcsb pdb:5KZ8 ensembl:ENSG00000111860(gene)|ensembl:ENST00000368491(transcript)|go:"GO:0000242"(pericentriolar material)|go:"GO:0001764"(neuron migration)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|interpro:IPR029778|interpro:IPR040210|refseq:XP_011534111.1|refseq:NP_001035940.1|refseq:NP_001171506.1|refseq:NP_996804.2|refseq:XP_016866335.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/09/18 rogid:yfUqSCu4bgkncBd6hRRg5pKkArc9606 rogid:N15ebFbq7U88FFmEjre+dOJsgeA9606 intact-crc:8CC685E772E6CABB|rigid:Z4RZV/2i2psYZ5ttHMwfpjdkVOo false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q7KZI7 uniprotkb:P41743 intact:EBI-516560|uniprotkb:Q15449|uniprotkb:Q15524|uniprotkb:Q5XGA3|uniprotkb:Q68A18|uniprotkb:Q96HB3|uniprotkb:Q96RG0|ensembl:ENSP00000385751 intact:EBI-286199|uniprotkb:Q8WW06|uniprotkb:D3DNQ4|ensembl:ENSP00000295797 psi-mi:mark2_human(display_long)|uniprotkb:MAP/microtubule affinity-regulating kinase 2(gene name synonym)|uniprotkb:ELKL motif kinase 1(gene name synonym)|uniprotkb:PAR1 homolog(gene name synonym)|uniprotkb:MARK2(gene name)|psi-mi:MARK2(display_short)|uniprotkb:EMK1(gene name synonym)|uniprotkb:PAR1 homolog b(gene name synonym) psi-mi:kpci_human(display_long)|uniprotkb:nPKC-iota(gene name synonym)|uniprotkb:Atypical protein kinase C-lambda/iota(gene name synonym)|uniprotkb:PRKCI(gene name)|psi-mi:PRKCI(display_short)|uniprotkb:DXS1179E(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514724|imex:IM-12079-93 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001034558.2|refseq:NP_001156768.1|refseq:NP_001156769.1|refseq:NP_004945.4|refseq:NP_059672.2|dip:DIP-31321N|ensembl:ENSG00000072518(gene)|ensembl:ENST00000402010(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0001764"(neuron migration)|go:"GO:0003723"(RNA binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008289"(lipid binding)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0045296"(cadherin binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048156"(tau protein binding)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030425"(dendrite)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0051646"(mitochondrion localization)|go:"GO:0061564"(axon development)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0071963"(establishment or maintenance of cell polarity regulating cell shape)|go:"GO:0097427"(microtubule bundle)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1904526"(regulation of microtubule binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001772(Kinase-associated KA1)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028375|mint:Q7KZI7|rcsb pdb:3IEC|rcsb pdb:5EAK|rcsb pdb:5KZ7|rcsb pdb:5KZ8 refseq:NP_002731.4|dip:DIP-31311N|ensembl:ENSG00000163558(gene)|ensembl:ENST00000295797(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004697"(protein kinase C activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007015"(actin filament organization)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016477"(cell migration)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0031252"(cell leading edge)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0035089"(establishment of apical/basal cell polarity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042462"(eye photoreceptor cell development)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043220"(Schmidt-Lanterman incisure)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045171"(intercellular bridge)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046872"(metal ion binding)|go:"GO:0046903"(secretion)|go:"GO:0048194"(Golgi vesicle budding)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0061024"(membrane organization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099072"(regulation of postsynaptic membrane neurotransmitter receptor levels)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012233(Protein kinase C, zeta/iota)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR020454|interpro:IPR034661|interpro:IPR034877|mint:P41743|rcsb pdb:1VD2|rcsb pdb:1WMH|rcsb pdb:1ZRZ|rcsb pdb:3A8W|rcsb pdb:3A8X|rcsb pdb:3ZH8|rcsb pdb:5LI1|rcsb pdb:5LI9|rcsb pdb:5LIH|rcsb pdb:6ILZ|reactome:R-HSA-1912408|reactome:R-HSA-209543|reactome:R-HSA-420029 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/09/18 rogid:yfUqSCu4bgkncBd6hRRg5pKkArc9606 rogid:v8sZdKjtlBejk0MH/9gwOjRqy+49606 intact-crc:8CC685E772E6CABB|rigid:Z4RZV/2i2psYZ5ttHMwfpjdkVOo false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q7KZI7 uniprotkb:P33176 intact:EBI-516560|uniprotkb:Q15449|uniprotkb:Q15524|uniprotkb:Q5XGA3|uniprotkb:Q68A18|uniprotkb:Q96HB3|uniprotkb:Q96RG0|ensembl:ENSP00000385751 intact:EBI-355878|uniprotkb:A0AVB2|uniprotkb:Q5VZ85|ensembl:ENSP00000307078 psi-mi:mark2_human(display_long)|uniprotkb:MAP/microtubule affinity-regulating kinase 2(gene name synonym)|uniprotkb:ELKL motif kinase 1(gene name synonym)|uniprotkb:PAR1 homolog(gene name synonym)|uniprotkb:MARK2(gene name)|psi-mi:MARK2(display_short)|uniprotkb:EMK1(gene name synonym)|uniprotkb:PAR1 homolog b(gene name synonym) psi-mi:kinh_human(display_long)|uniprotkb:KIF5B(gene name)|psi-mi:KIF5B(display_short)|uniprotkb:KNS(gene name synonym)|uniprotkb:KNS1(gene name synonym)|uniprotkb:Ubiquitous kinesin heavy chain(gene name synonym)|uniprotkb:Conventional kinesin heavy chain(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514724|imex:IM-12079-93 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001034558.2|refseq:NP_001156768.1|refseq:NP_001156769.1|refseq:NP_004945.4|refseq:NP_059672.2|dip:DIP-31321N|ensembl:ENSG00000072518(gene)|ensembl:ENST00000402010(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0001764"(neuron migration)|go:"GO:0003723"(RNA binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008289"(lipid binding)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0045296"(cadherin binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048156"(tau protein binding)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030425"(dendrite)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0051646"(mitochondrion localization)|go:"GO:0061564"(axon development)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0071963"(establishment or maintenance of cell polarity regulating cell shape)|go:"GO:0097427"(microtubule bundle)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1904526"(regulation of microtubule binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001772(Kinase-associated KA1)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028375|mint:Q7KZI7|rcsb pdb:3IEC|rcsb pdb:5EAK|rcsb pdb:5KZ7|rcsb pdb:5KZ8 refseq:NP_004512.1|ensembl:ENSG00000170759(gene)|ensembl:ENST00000302418(transcript)|go:"GO:0003777"(microtubule motor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0007028"(cytoplasm organization)|go:"GO:0007411"(axon guidance)|go:"GO:0008017"(microtubule binding)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0008574"(plus-end-directed microtubule motor activity)|go:"GO:0016020"(membrane)|go:"GO:0021766"(hippocampus development)|go:"GO:0030705"(cytoskeleton-dependent intracellular transport)|go:"GO:0031340"(positive regulation of vesicle fusion)|go:"GO:0031982"(vesicle)|go:"GO:0032230"(positive regulation of synaptic transmission, GABAergic)|go:"GO:0032418"(lysosome localization)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0034451"(centriolar satellite)|go:"GO:0035253"(ciliary rootlet)|go:"GO:0035617"(stress granule disassembly)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042267"(natural killer cell mediated cytotoxicity)|go:"GO:0042391"(regulation of membrane potential)|go:"GO:0042802"(identical protein binding)|go:"GO:0043268"(positive regulation of potassium ion transport)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045296"(cadherin binding)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0051642"(centrosome localization)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0072383"(plus-end-directed vesicle transport along microtubule)|go:"GO:0090316"(positive regulation of intracellular protein transport)|go:"GO:0098971"(anterograde dendritic transport of neurotransmitter receptor complex)|go:"GO:0099609"(microtubule lateral binding)|go:"GO:0099641"(anterograde axonal protein transport)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905152"(positive regulation of voltage-gated sodium channel activity)|go:"GO:1990048"(anterograde neuronal dense core vesicle transport)|go:"GO:1990049"(retrograde neuronal dense core vesicle transport)|interpro:IPR001752(Kinesin, motor region)|interpro:IPR019821|interpro:IPR027417|interpro:IPR027640|interpro:IPR036961|mint:P33176|rcsb pdb:1BG2|rcsb pdb:1MKJ|rcsb pdb:2P4N|rcsb pdb:3J8X|rcsb pdb:3J8Y|rcsb pdb:4HNA|rcsb pdb:4LNU|rcsb pdb:5LT0|rcsb pdb:5LT1|rcsb pdb:5LT2|rcsb pdb:5LT3|rcsb pdb:5LT4|rcsb pdb:6OJQ|reactome:R-HSA-2132295|reactome:R-HSA-264876|reactome:R-HSA-5625970|reactome:R-HSA-6811434|reactome:R-HSA-983189|dip:DIP-29244N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/09/18 rogid:yfUqSCu4bgkncBd6hRRg5pKkArc9606 rogid:2UUVZBn5EAd0xBA5IZDPWHX9i7U9606 intact-crc:8CC685E772E6CABB|rigid:Z4RZV/2i2psYZ5ttHMwfpjdkVOo false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q7KZI7 uniprotkb:Q92974 intact:EBI-516560|uniprotkb:Q15449|uniprotkb:Q15524|uniprotkb:Q5XGA3|uniprotkb:Q68A18|uniprotkb:Q96HB3|uniprotkb:Q96RG0|ensembl:ENSP00000385751 intact:EBI-302405|intact:EBI-1045693|uniprotkb:O75142|uniprotkb:Q15079|uniprotkb:Q5VY92|uniprotkb:Q8TDA3|uniprotkb:Q8WUG4|uniprotkb:Q9H023|ensembl:ENSP00000354837|uniprotkb:D3DVA6 psi-mi:mark2_human(display_long)|uniprotkb:MAP/microtubule affinity-regulating kinase 2(gene name synonym)|uniprotkb:ELKL motif kinase 1(gene name synonym)|uniprotkb:PAR1 homolog(gene name synonym)|uniprotkb:MARK2(gene name)|psi-mi:MARK2(display_short)|uniprotkb:EMK1(gene name synonym)|uniprotkb:PAR1 homolog b(gene name synonym) psi-mi:arhg2_human(display_long)|uniprotkb:ARHGEF2(gene name)|psi-mi:ARHGEF2(display_short)|uniprotkb:KIAA0651(gene name synonym)|uniprotkb:LFP40(gene name synonym)|uniprotkb:Guanine nucleotide exchange factor H1(gene name synonym)|uniprotkb:Microtubule-regulated Rho-GEF(gene name synonym)|uniprotkb:Proliferating cell nucleolar antigen p40(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514724|imex:IM-12079-93 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001034558.2|refseq:NP_001156768.1|refseq:NP_001156769.1|refseq:NP_004945.4|refseq:NP_059672.2|dip:DIP-31321N|ensembl:ENSG00000072518(gene)|ensembl:ENST00000402010(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0001764"(neuron migration)|go:"GO:0003723"(RNA binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008289"(lipid binding)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0045296"(cadherin binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048156"(tau protein binding)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030425"(dendrite)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0051646"(mitochondrion localization)|go:"GO:0061564"(axon development)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0071963"(establishment or maintenance of cell polarity regulating cell shape)|go:"GO:0097427"(microtubule bundle)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1904526"(regulation of microtubule binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001772(Kinase-associated KA1)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028375|mint:Q7KZI7|rcsb pdb:3IEC|rcsb pdb:5EAK|rcsb pdb:5KZ7|rcsb pdb:5KZ8 refseq:NP_001155855.1|refseq:NP_001155856.1|refseq:NP_004714.2|ensembl:ENSG00000116584(gene)|ensembl:ENST00000361247(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005874"(microtubule)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007015"(actin filament organization)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0007049"(cell cycle)|go:"GO:0008017"(microtubule binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031982"(vesicle)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:2001224"(positive regulation of neuron migration)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035899|interpro:IPR037806|interpro:IPR041020|mint:Q92974|rcsb pdb:5EFX|reactome:R-HSA-193648|reactome:R-HSA-416482|reactome:R-HSA-8980692|reactome:R-HSA-9013026|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0045087"(innate immune response)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0055059"(asymmetric neuroblast division)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0071225"(cellular response to muramyl dipeptide)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071474"(cellular hyperosmotic response)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1902219"(negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress) psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/09/18 rogid:yfUqSCu4bgkncBd6hRRg5pKkArc9606 rogid:GljUl7uzMi3HaFQsMybfT6KrW089606 intact-crc:8CC685E772E6CABB|rigid:Z4RZV/2i2psYZ5ttHMwfpjdkVOo false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q7KZI7 uniprotkb:O75122 intact:EBI-516560|uniprotkb:Q15449|uniprotkb:Q15524|uniprotkb:Q5XGA3|uniprotkb:Q68A18|uniprotkb:Q96HB3|uniprotkb:Q96RG0|ensembl:ENSP00000385751 intact:EBI-913524|ensembl:ENSP00000417518|uniprotkb:Q7L8F6|uniprotkb:Q8N6R6|uniprotkb:Q9BQT3|uniprotkb:Q9BQT4|uniprotkb:Q9H7A3|uniprotkb:Q9NSZ2|intact:EBI-2514712|uniprotkb:B2RTR1|uniprotkb:F5H604|intact:EBI-10967478 psi-mi:mark2_human(display_long)|uniprotkb:MAP/microtubule affinity-regulating kinase 2(gene name synonym)|uniprotkb:ELKL motif kinase 1(gene name synonym)|uniprotkb:PAR1 homolog(gene name synonym)|uniprotkb:MARK2(gene name)|psi-mi:MARK2(display_short)|uniprotkb:EMK1(gene name synonym)|uniprotkb:PAR1 homolog b(gene name synonym) psi-mi:clap2_human(display_long)|uniprotkb:CLASP2(gene name)|psi-mi:CLASP2(display_short)|uniprotkb:KIAA0627(gene name synonym)|uniprotkb:Cytoplasmic linker-associated protein 2(gene name synonym)|uniprotkb:Protein Orbit homolog 2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514724|imex:IM-12079-93 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001034558.2|refseq:NP_001156768.1|refseq:NP_001156769.1|refseq:NP_004945.4|refseq:NP_059672.2|dip:DIP-31321N|ensembl:ENSG00000072518(gene)|ensembl:ENST00000402010(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0001764"(neuron migration)|go:"GO:0003723"(RNA binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008289"(lipid binding)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0045296"(cadherin binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048156"(tau protein binding)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030425"(dendrite)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0051646"(mitochondrion localization)|go:"GO:0061564"(axon development)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0071963"(establishment or maintenance of cell polarity regulating cell shape)|go:"GO:0097427"(microtubule bundle)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1904526"(regulation of microtubule binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001772(Kinase-associated KA1)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028375|mint:Q7KZI7|rcsb pdb:3IEC|rcsb pdb:5EAK|rcsb pdb:5KZ7|rcsb pdb:5KZ8 ensembl:ENSG00000163539(gene)|go:"GO:0007030"(Golgi organization)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0008017"(microtubule binding)|go:"GO:0010458"(exit from mitosis)|ensembl:ENST00000480013(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000776"(kinetochore)|go:"GO:0002162"(dystroglycan binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005828"(kinetochore microtubule)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005876"(spindle microtubule)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006903"(vesicle targeting)|go:"GO:0007020"(microtubule nucleation)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0010470"(regulation of gastrulation)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010717"(regulation of epithelial to mesenchymal transition)|go:"GO:0016020"(membrane)|go:"GO:0030516"(regulation of axon extension)|go:"GO:0031023"(microtubule organizing center organization)|go:"GO:0031110"(regulation of microtubule polymerization or depolymerization)|go:"GO:0031113"(regulation of microtubule polymerization)|go:"GO:0031252"(cell leading edge)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0034453"(microtubule anchoring)|go:"GO:0035791"(platelet-derived growth factor receptor-beta signaling pathway)|go:"GO:0040001"(establishment of mitotic spindle localization)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045180"(basal cortex)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0051010"(microtubule plus-end binding)|go:"GO:0051015"(actin filament binding)|go:"GO:0051301"(cell division)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090091"(positive regulation of extracellular matrix disassembly)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:1903690"(negative regulation of wound healing, spreading of epidermal cells)|go:"GO:1903754"(cortical microtubule plus-end)|go:"GO:1904261"(positive regulation of basement membrane assembly involved in embryonic body morphogenesis)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR024395|interpro:IPR034085|mint:O75122|rcsb pdb:3WOY|rcsb pdb:5NR4|reactome:R-HSA-141444|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-428890|reactome:R-HSA-5663220|reactome:R-HSA-68877|reactome:R-HSA-9648025|refseq:NP_001193973.1|refseq:NP_055912.2|dip:DIP-36804N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/09/18 rogid:yfUqSCu4bgkncBd6hRRg5pKkArc9606 rogid:FNIEvRFPqFi6NPFLsVHlKvfkN9w9606 intact-crc:8CC685E772E6CABB|rigid:Z4RZV/2i2psYZ5ttHMwfpjdkVOo false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q7KZI7 uniprotkb:O60346 intact:EBI-516560|uniprotkb:Q15449|uniprotkb:Q15524|uniprotkb:Q5XGA3|uniprotkb:Q68A18|uniprotkb:Q96HB3|uniprotkb:Q96RG0|ensembl:ENSP00000385751 intact:EBI-2511516|intact:EBI-28974360|ensembl:ENSP00000262719|uniprotkb:Q6PJI6|uniprotkb:Q6P4C4|uniprotkb:A1A4F5|uniprotkb:Q641Q7|uniprotkb:Q86TN6|uniprotkb:Q96FK2|uniprotkb:Q9NUY1 psi-mi:mark2_human(display_long)|uniprotkb:MAP/microtubule affinity-regulating kinase 2(gene name synonym)|uniprotkb:ELKL motif kinase 1(gene name synonym)|uniprotkb:PAR1 homolog(gene name synonym)|uniprotkb:MARK2(gene name)|psi-mi:MARK2(display_short)|uniprotkb:EMK1(gene name synonym)|uniprotkb:PAR1 homolog b(gene name synonym) psi-mi:phlp1_human(display_long)|uniprotkb:PHLPP1(gene name)|psi-mi:PHLPP1(display_short)|uniprotkb:KIAA0606(gene name synonym)|uniprotkb:PHLPP(gene name synonym)|uniprotkb:PLEKHE1(gene name synonym)|uniprotkb:SCOP(gene name synonym)|uniprotkb:Pleckstrin homology domain-containing family E member 1(gene name synonym)|uniprotkb:Suprachiasmatic nucleus circadian oscillatory protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514724|imex:IM-12079-93 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001034558.2|refseq:NP_001156768.1|refseq:NP_001156769.1|refseq:NP_004945.4|refseq:NP_059672.2|dip:DIP-31321N|ensembl:ENSG00000072518(gene)|ensembl:ENST00000402010(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0001764"(neuron migration)|go:"GO:0003723"(RNA binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008289"(lipid binding)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0045296"(cadherin binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048156"(tau protein binding)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030425"(dendrite)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0051646"(mitochondrion localization)|go:"GO:0061564"(axon development)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0071963"(establishment or maintenance of cell polarity regulating cell shape)|go:"GO:0097427"(microtubule bundle)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1904526"(regulation of microtubule binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001772(Kinase-associated KA1)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028375|mint:Q7KZI7|rcsb pdb:3IEC|rcsb pdb:5EAK|rcsb pdb:5KZ7|rcsb pdb:5KZ8 ensembl:ENSP00000262719|go:"GO:0009649"(entrainment of circadian clock)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046872"(metal ion binding)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1900744"(regulation of p38MAPK cascade)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001932(Protein phosphatase 2C-related)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR032675|interpro:IPR036457|mint:O60346|reactome:R-HSA-199418|ensembl:ENSG00000081913(gene)|ensembl:ENST00000262719(transcript)|go:"GO:0002667"(regulation of T cell anergy)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|refseq:NP_919431.2 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/09/18 rogid:yfUqSCu4bgkncBd6hRRg5pKkArc9606 rogid:hPGjeSVMlJhO3o9YBWoBm9xppfk9606 intact-crc:8CC685E772E6CABB|rigid:Z4RZV/2i2psYZ5ttHMwfpjdkVOo false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q7KZI7 uniprotkb:P27448 intact:EBI-516560|uniprotkb:Q15449|uniprotkb:Q15524|uniprotkb:Q5XGA3|uniprotkb:Q68A18|uniprotkb:Q96HB3|uniprotkb:Q96RG0|ensembl:ENSP00000385751 intact:EBI-707595|uniprotkb:O60219|uniprotkb:Q8TB41|uniprotkb:Q8WX83|uniprotkb:Q96RG1|uniprotkb:Q9UMY9|uniprotkb:Q9UN34|uniprotkb:Q86TT8|uniprotkb:A0A0A0MQR8|uniprotkb:A0A0A0MST9|uniprotkb:A0A0A0MT23|ensembl:ENSP00000411397 psi-mi:mark2_human(display_long)|uniprotkb:MAP/microtubule affinity-regulating kinase 2(gene name synonym)|uniprotkb:ELKL motif kinase 1(gene name synonym)|uniprotkb:PAR1 homolog(gene name synonym)|uniprotkb:MARK2(gene name)|psi-mi:MARK2(display_short)|uniprotkb:EMK1(gene name synonym)|uniprotkb:PAR1 homolog b(gene name synonym) psi-mi:mark3_human(display_long)|uniprotkb:Cdc25C-associated protein kinase 1(gene name synonym)|uniprotkb:C-TAK1(gene name synonym)|uniprotkb:Serine/threonine-protein kinase p78(gene name synonym)|uniprotkb:Ser/Thr protein kinase PAR-1(gene name synonym)|uniprotkb:Protein kinase STK10(gene name synonym)|uniprotkb:MARK3(gene name)|psi-mi:MARK3(display_short)|uniprotkb:CTAK1(gene name synonym)|uniprotkb:EMK2(gene name synonym)|uniprotkb:ELKL motif kinase 2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514724|imex:IM-12079-93 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001034558.2|refseq:NP_001156768.1|refseq:NP_001156769.1|refseq:NP_004945.4|refseq:NP_059672.2|dip:DIP-31321N|ensembl:ENSG00000072518(gene)|ensembl:ENST00000402010(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0001764"(neuron migration)|go:"GO:0003723"(RNA binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008289"(lipid binding)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0045296"(cadherin binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048156"(tau protein binding)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030425"(dendrite)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0051646"(mitochondrion localization)|go:"GO:0061564"(axon development)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0071963"(establishment or maintenance of cell polarity regulating cell shape)|go:"GO:0097427"(microtubule bundle)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1904526"(regulation of microtubule binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001772(Kinase-associated KA1)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028375|mint:Q7KZI7|rcsb pdb:3IEC|rcsb pdb:5EAK|rcsb pdb:5KZ7|rcsb pdb:5KZ8 refseq:NP_001122390.2|refseq:NP_001122391.2|refseq:NP_001122392.2|refseq:NP_001122393.2|refseq:NP_002367.5|dip:DIP-34637N|ensembl:ENSG00000075413(gene)|ensembl:ENST00000429436(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030425"(dendrite)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0035331"(negative regulation of hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036289"(peptidyl-serine autophosphorylation)|go:"GO:0048156"(tau protein binding)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001772(Kinase-associated KA1)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028375|interpro:IPR033628|mint:P27448|rcsb pdb:2QNJ|rcsb pdb:3FE3|rcsb pdb:7O94|reactome:R-HSA-5673000|reactome:R-HSA-5674135|reactome:R-HSA-5675221|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-9649948|reactome:R-HSA-9656223 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/09/18 rogid:yfUqSCu4bgkncBd6hRRg5pKkArc9606 rogid:YoMdp32OqT0OCgUUBwxSEHmA+vs9606 intact-crc:8CC685E772E6CABB|rigid:Z4RZV/2i2psYZ5ttHMwfpjdkVOo false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q7KZI7 uniprotkb:Q9NQT8 intact:EBI-516560|uniprotkb:Q15449|uniprotkb:Q15524|uniprotkb:Q5XGA3|uniprotkb:Q68A18|uniprotkb:Q96HB3|uniprotkb:Q96RG0|ensembl:ENSP00000385751 intact:EBI-766408|uniprotkb:O75134|uniprotkb:Q9BYJ6|intact:EBI-11144050|uniprotkb:F8VPJ2|uniprotkb:B4DGY5|uniprotkb:B5MC45|ensembl:ENSP00000427900 psi-mi:mark2_human(display_long)|uniprotkb:MAP/microtubule affinity-regulating kinase 2(gene name synonym)|uniprotkb:ELKL motif kinase 1(gene name synonym)|uniprotkb:PAR1 homolog(gene name synonym)|uniprotkb:MARK2(gene name)|psi-mi:MARK2(display_short)|uniprotkb:EMK1(gene name synonym)|uniprotkb:PAR1 homolog b(gene name synonym) psi-mi:ki13b_human(display_long)|uniprotkb:Kinesin-like protein GAKIN(gene name synonym)|uniprotkb:KIF13B(gene name)|psi-mi:KIF13B(display_short)|uniprotkb:GAKIN(gene name synonym)|uniprotkb:KIAA0639(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514724|imex:IM-12079-93 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001034558.2|refseq:NP_001156768.1|refseq:NP_001156769.1|refseq:NP_004945.4|refseq:NP_059672.2|dip:DIP-31321N|ensembl:ENSG00000072518(gene)|ensembl:ENST00000402010(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0001764"(neuron migration)|go:"GO:0003723"(RNA binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008289"(lipid binding)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0045296"(cadherin binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048156"(tau protein binding)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030425"(dendrite)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0051646"(mitochondrion localization)|go:"GO:0061564"(axon development)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0071963"(establishment or maintenance of cell polarity regulating cell shape)|go:"GO:0097427"(microtubule bundle)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1904526"(regulation of microtubule binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001772(Kinase-associated KA1)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028375|mint:Q7KZI7|rcsb pdb:3IEC|rcsb pdb:5EAK|rcsb pdb:5KZ7|rcsb pdb:5KZ8 refseq:NP_056069.2|dip:DIP-34586N|ensembl:ENSG00000197892(gene)|ensembl:ENST00000524189(transcript)|go:"GO:0003777"(microtubule motor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|go:"GO:0005902"(microvillus)|go:"GO:0006605"(protein targeting)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0007165"(signal transduction)|go:"GO:0008017"(microtubule binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030424"(axon)|go:"GO:0033270"(paranode region of axon)|go:"GO:0042110"(T cell activation)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:1990939"|interpro:IPR000253(Forkhead-associated)|interpro:IPR000938(Cytoskeleton-associated protein, CAP-Gly)|interpro:IPR001752(Kinesin, motor region)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR019821|interpro:IPR022140|interpro:IPR022164|interpro:IPR027417|interpro:IPR032405|interpro:IPR036859|interpro:IPR036961|rcsb pdb:2COW|rcsb pdb:3FM8|rcsb pdb:3GBJ|rcsb pdb:3MDB|reactome:R-HSA-6811434|reactome:R-HSA-983189 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/09/18 rogid:yfUqSCu4bgkncBd6hRRg5pKkArc9606 rogid:dasf1WDho4yX7DWVOYfIpVNcRlE9606 intact-crc:8CC685E772E6CABB|rigid:Z4RZV/2i2psYZ5ttHMwfpjdkVOo false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q7KZI7 uniprotkb:Q9Y5J1 intact:EBI-516560|uniprotkb:Q15449|uniprotkb:Q15524|uniprotkb:Q5XGA3|uniprotkb:Q68A18|uniprotkb:Q96HB3|uniprotkb:Q96RG0|ensembl:ENSP00000385751 intact:EBI-592816|uniprotkb:Q9H4N6|ensembl:ENSP00000225298 psi-mi:mark2_human(display_long)|uniprotkb:MAP/microtubule affinity-regulating kinase 2(gene name synonym)|uniprotkb:ELKL motif kinase 1(gene name synonym)|uniprotkb:PAR1 homolog(gene name synonym)|uniprotkb:MARK2(gene name)|psi-mi:MARK2(display_short)|uniprotkb:EMK1(gene name synonym)|uniprotkb:PAR1 homolog b(gene name synonym) psi-mi:utp18_human(display_long)|uniprotkb:WD repeat-containing protein 50(gene name synonym)|uniprotkb:UTP18(gene name)|psi-mi:UTP18(display_short)|uniprotkb:CGI-48(orf name)|uniprotkb:CDABP0061(orf name)|uniprotkb:WDR50(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514724|imex:IM-12079-93 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001034558.2|refseq:NP_001156768.1|refseq:NP_001156769.1|refseq:NP_004945.4|refseq:NP_059672.2|dip:DIP-31321N|ensembl:ENSG00000072518(gene)|ensembl:ENST00000402010(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0001764"(neuron migration)|go:"GO:0003723"(RNA binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008289"(lipid binding)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0045296"(cadherin binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048156"(tau protein binding)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030425"(dendrite)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0051646"(mitochondrion localization)|go:"GO:0061564"(axon development)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0071963"(establishment or maintenance of cell polarity regulating cell shape)|go:"GO:0097427"(microtubule bundle)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1904526"(regulation of microtubule binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001772(Kinase-associated KA1)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028375|mint:Q7KZI7|rcsb pdb:3IEC|rcsb pdb:5EAK|rcsb pdb:5KZ7|rcsb pdb:5KZ8 refseq:NP_057085.2|ensembl:ENSG00000011260(gene)|ensembl:ENST00000225298(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006364"(rRNA processing)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032040"(small-subunit processome)|go:"GO:0034388"(Pwp2p-containing subcomplex of 90S preribosome)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|mint:Q9Y5J1|reactome:R-HSA-6790901|reactome:R-HSA-6791226 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/09/18 rogid:yfUqSCu4bgkncBd6hRRg5pKkArc9606 rogid:l873IUyfCql4N9VelHPuUEqpzRY9606 intact-crc:8CC685E772E6CABB|rigid:Z4RZV/2i2psYZ5ttHMwfpjdkVOo false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q7KZI7 uniprotkb:Q9Y4B5 intact:EBI-516560|uniprotkb:Q15449|uniprotkb:Q15524|uniprotkb:Q5XGA3|uniprotkb:Q68A18|uniprotkb:Q96HB3|uniprotkb:Q96RG0|ensembl:ENSP00000385751 intact:EBI-302423|uniprotkb:Q6ZMQ9|uniprotkb:Q8IWA9|intact:EBI-28975975|ensembl:ENSP00000305027|intact:EBI-2554582|uniprotkb:E9PAY7 psi-mi:mark2_human(display_long)|uniprotkb:MAP/microtubule affinity-regulating kinase 2(gene name synonym)|uniprotkb:ELKL motif kinase 1(gene name synonym)|uniprotkb:PAR1 homolog(gene name synonym)|uniprotkb:MARK2(gene name)|psi-mi:MARK2(display_short)|uniprotkb:EMK1(gene name synonym)|uniprotkb:PAR1 homolog b(gene name synonym) psi-mi:mtcl1_human(display_long)|uniprotkb:MTCL1(gene name)|psi-mi:MTCL1(display_short)|uniprotkb:CCDC165(gene name synonym)|uniprotkb:Coiled-coil domain-containing protein 165(gene name synonym)|uniprotkb:KIAA0802(gene name synonym)|uniprotkb:PAR-1-interacting protein(gene name synonym)|uniprotkb:SOGA family member 2(gene name synonym)|uniprotkb:SOGA2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514724|imex:IM-12079-93 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001034558.2|refseq:NP_001156768.1|refseq:NP_001156769.1|refseq:NP_004945.4|refseq:NP_059672.2|dip:DIP-31321N|ensembl:ENSG00000072518(gene)|ensembl:ENST00000402010(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0001764"(neuron migration)|go:"GO:0003723"(RNA binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008289"(lipid binding)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0045296"(cadherin binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048156"(tau protein binding)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030425"(dendrite)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0051646"(mitochondrion localization)|go:"GO:0061564"(axon development)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0071963"(establishment or maintenance of cell polarity regulating cell shape)|go:"GO:0097427"(microtubule bundle)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1904526"(regulation of microtubule binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001772(Kinase-associated KA1)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028375|mint:Q7KZI7|rcsb pdb:3IEC|rcsb pdb:5EAK|rcsb pdb:5KZ7|rcsb pdb:5KZ8 refseq:NP_056025.2|ensembl:ENSG00000168502(gene)|ensembl:ENST00000306329(transcript)|go:"GO:0000922"(spindle pole)|go:"GO:0001578"(microtubule bundle formation)|go:"GO:0003723"(RNA binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0008017"(microtubule binding)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0030496"(midbody)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0097427"(microtubule bundle)|go:"GO:2000576"(obsolete positive regulation of microtubule motor activity)|interpro:IPR027881|interpro:IPR027882|ensembl:ENSP00000305027|ensembl:ENST00000359865|ensembl:ENSP00000352927|ensembl:ENST00000400050|ensembl:ENSP00000382924|ensembl:ENSP00000429556|ensembl:ENST00000518815|ensembl:ENSP00000463465|ensembl:ENST00000517570|refseq:XP_005258156.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/09/18 rogid:yfUqSCu4bgkncBd6hRRg5pKkArc9606 rogid:RxNB5mpEiLNQpsyKLfaw0LyqsVU9606 intact-crc:8CC685E772E6CABB|rigid:Z4RZV/2i2psYZ5ttHMwfpjdkVOo false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q7KZI7 uniprotkb:Q9Y5P4 intact:EBI-516560|uniprotkb:Q15449|uniprotkb:Q15524|uniprotkb:Q5XGA3|uniprotkb:Q68A18|uniprotkb:Q96HB3|uniprotkb:Q96RG0|ensembl:ENSP00000385751 intact:EBI-739994|uniprotkb:Q96Q85|uniprotkb:Q96Q88|uniprotkb:Q9H2S7|uniprotkb:Q9H2S8|uniprotkb:Q53YV1|uniprotkb:Q53YV2|uniprotkb:A8K7S2|uniprotkb:B3KUB7|ensembl:ENSP00000261415|ensembl:ENSP00000494110|ensembl:ENSP00000495760 psi-mi:mark2_human(display_long)|uniprotkb:MAP/microtubule affinity-regulating kinase 2(gene name synonym)|uniprotkb:ELKL motif kinase 1(gene name synonym)|uniprotkb:PAR1 homolog(gene name synonym)|uniprotkb:MARK2(gene name)|psi-mi:MARK2(display_short)|uniprotkb:EMK1(gene name synonym)|uniprotkb:PAR1 homolog b(gene name synonym) psi-mi:cert_human(display_long)|uniprotkb:CERT1(gene name)|psi-mi:CERT1(display_short)|uniprotkb:CERT(gene name synonym)|uniprotkb:COL4A3BP(gene name synonym)|uniprotkb:Collagen type IV alpha-3-binding protein(gene name synonym)|uniprotkb:Goodpasture antigen-binding protein(gene name synonym)|uniprotkb:STARD11(gene name synonym)|uniprotkb:START domain-containing protein 11(gene name synonym)|uniprotkb:StAR-related lipid transfer protein 11(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514724|imex:IM-12079-93 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001034558.2|refseq:NP_001156768.1|refseq:NP_001156769.1|refseq:NP_004945.4|refseq:NP_059672.2|dip:DIP-31321N|ensembl:ENSG00000072518(gene)|ensembl:ENST00000402010(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0001764"(neuron migration)|go:"GO:0003723"(RNA binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008289"(lipid binding)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0045296"(cadherin binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048156"(tau protein binding)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030425"(dendrite)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0051646"(mitochondrion localization)|go:"GO:0061564"(axon development)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0071963"(establishment or maintenance of cell polarity regulating cell shape)|go:"GO:0097427"(microtubule bundle)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1904526"(regulation of microtubule binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001772(Kinase-associated KA1)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028375|mint:Q7KZI7|rcsb pdb:3IEC|rcsb pdb:5EAK|rcsb pdb:5KZ7|rcsb pdb:5KZ8 refseq:NP_001123577.1|refseq:NP_005704.1|refseq:NP_112729.1|refseq:XP_016864408.1|rcsb pdb:2E3P|rcsb pdb:2E3Q|rcsb pdb:2E3R|rcsb pdb:2E3S|rcsb pdb:2RSG|rcsb pdb:2Z9Y|rcsb pdb:2Z9Z|rcsb pdb:3H3Q|rcsb pdb:3H3R|rcsb pdb:3H3S|rcsb pdb:3H3T|rcsb pdb:4HHV|rcsb pdb:5JJD|rcsb pdb:5ZYG|rcsb pdb:5ZYH|rcsb pdb:5ZYI|rcsb pdb:5ZYJ|rcsb pdb:5ZYK|rcsb pdb:5ZYL|rcsb pdb:5ZYM|rcsb pdb:6IEZ|rcsb pdb:6IF0|rcsb pdb:6J0O|rcsb pdb:6J81|reactome:R-HSA-1660661|ensembl:ENSG00000113163(gene)|ensembl:ENST00000261415(transcript)|ensembl:ENST00000643780(transcript)|ensembl:ENST00000644072(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0006936"(muscle contraction)|go:"GO:0006955"(immune response)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0007165"(signal transduction)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035621"(ER to Golgi ceramide transport)|go:"GO:0035627"(ceramide transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0055088"(lipid homeostasis)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:0070584"(mitochondrion morphogenesis)|go:"GO:0097001"(ceramide binding)|go:"GO:0120009"(intermembrane lipid transfer)|go:"GO:0120012"(intermembrane sphingolipid transfer)|go:"GO:0120017"(ceramide transfer activity)|go:"GO:1902387"(ceramide 1-phosphate binding)|go:"GO:1902388"(ceramide 1-phosphate transfer activity)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002913(Lipid-binding START)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR023393|interpro:IPR041952|mint:Q9Y5P4|rcsb pdb:2E3M|rcsb pdb:2E3N|rcsb pdb:2E3O|refseq:XP_006714576.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/09/18 rogid:yfUqSCu4bgkncBd6hRRg5pKkArc9606 rogid:AohUpOJQHInz8f5bKv9/Xb5K+/Y9606 intact-crc:8CC685E772E6CABB|rigid:Z4RZV/2i2psYZ5ttHMwfpjdkVOo false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q7KZI7 uniprotkb:Q9P0L2 intact:EBI-516560|uniprotkb:Q15449|uniprotkb:Q15524|uniprotkb:Q5XGA3|uniprotkb:Q68A18|uniprotkb:Q96HB3|uniprotkb:Q96RG0|ensembl:ENSP00000385751 intact:EBI-968587|uniprotkb:Q2HIY1|uniprotkb:Q5VTF9|uniprotkb:Q5VTG0|uniprotkb:Q96SW9|uniprotkb:Q9P251|uniprotkb:D3DTB0|uniprotkb:D3DTB1|ensembl:ENSP00000355884 psi-mi:mark2_human(display_long)|uniprotkb:MAP/microtubule affinity-regulating kinase 2(gene name synonym)|uniprotkb:ELKL motif kinase 1(gene name synonym)|uniprotkb:PAR1 homolog(gene name synonym)|uniprotkb:MARK2(gene name)|psi-mi:MARK2(display_short)|uniprotkb:EMK1(gene name synonym)|uniprotkb:PAR1 homolog b(gene name synonym) psi-mi:mark1_human(display_long)|uniprotkb:MARK1(gene name)|psi-mi:MARK1(display_short)|uniprotkb:KIAA1477(gene name synonym)|uniprotkb:MARK(gene name synonym)|uniprotkb:MAP/microtubule affinity-regulating kinase 1(gene name synonym)|uniprotkb:PAR1 homolog c(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514724|imex:IM-12079-93 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001034558.2|refseq:NP_001156768.1|refseq:NP_001156769.1|refseq:NP_004945.4|refseq:NP_059672.2|dip:DIP-31321N|ensembl:ENSG00000072518(gene)|ensembl:ENST00000402010(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0001764"(neuron migration)|go:"GO:0003723"(RNA binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008289"(lipid binding)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0045296"(cadherin binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048156"(tau protein binding)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030425"(dendrite)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0051646"(mitochondrion localization)|go:"GO:0061564"(axon development)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0071963"(establishment or maintenance of cell polarity regulating cell shape)|go:"GO:0097427"(microtubule bundle)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1904526"(regulation of microtubule binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001772(Kinase-associated KA1)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028375|mint:Q7KZI7|rcsb pdb:3IEC|rcsb pdb:5EAK|rcsb pdb:5KZ7|rcsb pdb:5KZ8 refseq:NP_001273057.1|refseq:NP_061120.3|ensembl:ENSP00000355884|ensembl:ENST00000366918|ensembl:ENSP00000355885|dip:DIP-39777N|ensembl:ENSG00000116141(gene)|ensembl:ENST00000366917(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001764"(neuron migration)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030425"(dendrite)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0048156"(tau protein binding)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0051654"(establishment of mitochondrion localization)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001772(Kinase-associated KA1)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028375|interpro:IPR033627|mint:Q9P0L2|rcsb pdb:2HAK|rcsb pdb:3OSE|rcsb pdb:6C9D psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/09/18 rogid:yfUqSCu4bgkncBd6hRRg5pKkArc9606 rogid:/ydFAiGjuUcmwDHO4tEPSSMlVjY9606 intact-crc:8CC685E772E6CABB|rigid:Z4RZV/2i2psYZ5ttHMwfpjdkVOo false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q7KZI7 uniprotkb:Q9Y4B5 intact:EBI-516560|uniprotkb:Q15449|uniprotkb:Q15524|uniprotkb:Q5XGA3|uniprotkb:Q68A18|uniprotkb:Q96HB3|uniprotkb:Q96RG0|ensembl:ENSP00000385751 intact:EBI-302423|uniprotkb:Q6ZMQ9|uniprotkb:Q8IWA9|intact:EBI-28975975|ensembl:ENSP00000305027|intact:EBI-2554582|uniprotkb:E9PAY7 psi-mi:mark2_human(display_long)|uniprotkb:MAP/microtubule affinity-regulating kinase 2(gene name synonym)|uniprotkb:ELKL motif kinase 1(gene name synonym)|uniprotkb:PAR1 homolog(gene name synonym)|uniprotkb:MARK2(gene name)|psi-mi:MARK2(display_short)|uniprotkb:EMK1(gene name synonym)|uniprotkb:PAR1 homolog b(gene name synonym) psi-mi:mtcl1_human(display_long)|uniprotkb:MTCL1(gene name)|psi-mi:MTCL1(display_short)|uniprotkb:CCDC165(gene name synonym)|uniprotkb:Coiled-coil domain-containing protein 165(gene name synonym)|uniprotkb:KIAA0802(gene name synonym)|uniprotkb:PAR-1-interacting protein(gene name synonym)|uniprotkb:SOGA family member 2(gene name synonym)|uniprotkb:SOGA2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514724|imex:IM-12079-93 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001034558.2|refseq:NP_001156768.1|refseq:NP_001156769.1|refseq:NP_004945.4|refseq:NP_059672.2|dip:DIP-31321N|ensembl:ENSG00000072518(gene)|ensembl:ENST00000402010(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0001764"(neuron migration)|go:"GO:0003723"(RNA binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008289"(lipid binding)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0045296"(cadherin binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048156"(tau protein binding)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030425"(dendrite)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0051646"(mitochondrion localization)|go:"GO:0061564"(axon development)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0071963"(establishment or maintenance of cell polarity regulating cell shape)|go:"GO:0097427"(microtubule bundle)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1904526"(regulation of microtubule binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001772(Kinase-associated KA1)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028375|mint:Q7KZI7|rcsb pdb:3IEC|rcsb pdb:5EAK|rcsb pdb:5KZ7|rcsb pdb:5KZ8 refseq:NP_056025.2|ensembl:ENSG00000168502(gene)|ensembl:ENST00000306329(transcript)|go:"GO:0000922"(spindle pole)|go:"GO:0001578"(microtubule bundle formation)|go:"GO:0003723"(RNA binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0008017"(microtubule binding)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0030496"(midbody)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0097427"(microtubule bundle)|go:"GO:2000576"(obsolete positive regulation of microtubule motor activity)|interpro:IPR027881|interpro:IPR027882|ensembl:ENSP00000305027|ensembl:ENST00000359865|ensembl:ENSP00000352927|ensembl:ENST00000400050|ensembl:ENSP00000382924|ensembl:ENSP00000429556|ensembl:ENST00000518815|ensembl:ENSP00000463465|ensembl:ENST00000517570|refseq:XP_005258156.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/09/18 rogid:yfUqSCu4bgkncBd6hRRg5pKkArc9606 rogid:RxNB5mpEiLNQpsyKLfaw0LyqsVU9606 intact-crc:8CC685E772E6CABB|rigid:Z4RZV/2i2psYZ5ttHMwfpjdkVOo false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q7KZI7 uniprotkb:Q10713 intact:EBI-516560|uniprotkb:Q15449|uniprotkb:Q15524|uniprotkb:Q5XGA3|uniprotkb:Q68A18|uniprotkb:Q96HB3|uniprotkb:Q96RG0|ensembl:ENSP00000385751 intact:EBI-2514696|ensembl:ENSP00000360782|uniprotkb:Q8N513|uniprotkb:Q16639|uniprotkb:Q5SXM9|uniprotkb:B4DKL3|uniprotkb:E7ET61 psi-mi:mark2_human(display_long)|uniprotkb:MAP/microtubule affinity-regulating kinase 2(gene name synonym)|uniprotkb:ELKL motif kinase 1(gene name synonym)|uniprotkb:PAR1 homolog(gene name synonym)|uniprotkb:MARK2(gene name)|psi-mi:MARK2(display_short)|uniprotkb:EMK1(gene name synonym)|uniprotkb:PAR1 homolog b(gene name synonym) psi-mi:mppa_human(display_long)|uniprotkb:PMPCA(gene name)|psi-mi:PMPCA(display_short)|uniprotkb:INPP5E(gene name synonym)|uniprotkb:KIAA0123(gene name synonym)|uniprotkb:MPPA(gene name synonym)|uniprotkb:Alpha-MPP(gene name synonym)|uniprotkb:P-55(gene name synonym)|uniprotkb:Inactive zinc metalloprotease alpha(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514724|imex:IM-12079-93 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001034558.2|refseq:NP_001156768.1|refseq:NP_001156769.1|refseq:NP_004945.4|refseq:NP_059672.2|dip:DIP-31321N|ensembl:ENSG00000072518(gene)|ensembl:ENST00000402010(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0001764"(neuron migration)|go:"GO:0003723"(RNA binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008289"(lipid binding)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0045296"(cadherin binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048156"(tau protein binding)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030425"(dendrite)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0051646"(mitochondrion localization)|go:"GO:0061564"(axon development)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0071963"(establishment or maintenance of cell polarity regulating cell shape)|go:"GO:0097427"(microtubule bundle)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1904526"(regulation of microtubule binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001772(Kinase-associated KA1)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028375|mint:Q7KZI7|rcsb pdb:3IEC|rcsb pdb:5EAK|rcsb pdb:5KZ7|rcsb pdb:5KZ8 refseq:NP_001269875.1|ensembl:ENSG00000165688(gene)|ensembl:ENST00000371717(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006627"(protein processing involved in protein targeting to mitochondrion)|go:"GO:0046872"(metal ion binding)|interpro:IPR001431(Peptidase M16, zinc-binding site)|interpro:IPR007863(Peptidase M16, C-terminal)|interpro:IPR011249(Metalloenzyme, LuxS/M16 peptidase-like, metal-binding)|interpro:IPR011765(Peptidase M16, N-terminal)|reactome:R-HSA-1268020|reactome:R-HSA-8949664|interpro:IPR037715|refseq:NP_001269873.1|refseq:NP_055975.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/09/18 rogid:yfUqSCu4bgkncBd6hRRg5pKkArc9606 rogid:Kqz7qIyX2eUOcnNrfIsSPjc4Isw9606 intact-crc:8CC685E772E6CABB|rigid:Z4RZV/2i2psYZ5ttHMwfpjdkVOo false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q7KZI7 uniprotkb:Q04917 intact:EBI-516560|uniprotkb:Q15449|uniprotkb:Q15524|uniprotkb:Q5XGA3|uniprotkb:Q68A18|uniprotkb:Q96HB3|uniprotkb:Q96RG0|ensembl:ENSP00000385751 intact:EBI-306940|ensembl:ENSP00000248975|intact:EBI-11759595 psi-mi:mark2_human(display_long)|uniprotkb:MAP/microtubule affinity-regulating kinase 2(gene name synonym)|uniprotkb:ELKL motif kinase 1(gene name synonym)|uniprotkb:PAR1 homolog(gene name synonym)|uniprotkb:MARK2(gene name)|psi-mi:MARK2(display_short)|uniprotkb:EMK1(gene name synonym)|uniprotkb:PAR1 homolog b(gene name synonym) psi-mi:1433f_human(display_long)|uniprotkb:YWHAH(gene name)|psi-mi:YWHAH(display_short)|uniprotkb:YWHA1(gene name synonym)|uniprotkb:Protein AS1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514724|imex:IM-12079-93 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001034558.2|refseq:NP_001156768.1|refseq:NP_001156769.1|refseq:NP_004945.4|refseq:NP_059672.2|dip:DIP-31321N|ensembl:ENSG00000072518(gene)|ensembl:ENST00000402010(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0001764"(neuron migration)|go:"GO:0003723"(RNA binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008289"(lipid binding)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0045296"(cadherin binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048156"(tau protein binding)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030425"(dendrite)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0051646"(mitochondrion localization)|go:"GO:0061564"(axon development)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0071963"(establishment or maintenance of cell polarity regulating cell shape)|go:"GO:0097427"(microtubule bundle)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1904526"(regulation of microtubule binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001772(Kinase-associated KA1)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028375|mint:Q7KZI7|rcsb pdb:3IEC|rcsb pdb:5EAK|rcsb pdb:5KZ7|rcsb pdb:5KZ8 go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0050774"(negative regulation of dendrite morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0086010"(membrane depolarization during action potential)|go:"GO:2000649"(regulation of sodium ion transmembrane transporter activity)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:Q04917|rcsb pdb:2C63|rcsb pdb:2C74|reactome:R-HSA-111447|reactome:R-HSA-1445148|reactome:R-HSA-5625740|reactome:R-HSA-5628897|reactome:R-HSA-75035|ensembl:ENSG00000128245(gene)|ensembl:ENST00000248975(transcript)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0003779"(actin binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006713"(glucocorticoid catabolic process)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0014704"(intercalated disc)|go:"GO:0017080"(sodium channel regulator activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021762"(substantia nigra development)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042921"(glucocorticoid receptor signaling pathway)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|refseq:NP_003396.1|dip:DIP-27566N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/09/18 rogid:yfUqSCu4bgkncBd6hRRg5pKkArc9606 rogid:VhFYPSsW3IRC388FTlmwwN37HnU9606 intact-crc:8CC685E772E6CABB|rigid:Z4RZV/2i2psYZ5ttHMwfpjdkVOo false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q7KZI7 uniprotkb:P46939 intact:EBI-516560|uniprotkb:Q15449|uniprotkb:Q15524|uniprotkb:Q5XGA3|uniprotkb:Q68A18|uniprotkb:Q96HB3|uniprotkb:Q96RG0|ensembl:ENSP00000385751 intact:EBI-295856|intact:EBI-784141|uniprotkb:Q5SZ57|uniprotkb:Q5SYY1|uniprotkb:Q9UJ40|ensembl:ENSP00000356515 psi-mi:mark2_human(display_long)|uniprotkb:MAP/microtubule affinity-regulating kinase 2(gene name synonym)|uniprotkb:ELKL motif kinase 1(gene name synonym)|uniprotkb:PAR1 homolog(gene name synonym)|uniprotkb:MARK2(gene name)|psi-mi:MARK2(display_short)|uniprotkb:EMK1(gene name synonym)|uniprotkb:PAR1 homolog b(gene name synonym) psi-mi:utrn_human(display_long)|uniprotkb:UTRN(gene name)|psi-mi:UTRN(display_short)|uniprotkb:DMDL(gene name synonym)|uniprotkb:Dystrophin-related protein 1(gene name synonym)|uniprotkb:DRP1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514724|imex:IM-12079-93 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001034558.2|refseq:NP_001156768.1|refseq:NP_001156769.1|refseq:NP_004945.4|refseq:NP_059672.2|dip:DIP-31321N|ensembl:ENSG00000072518(gene)|ensembl:ENST00000402010(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0001764"(neuron migration)|go:"GO:0003723"(RNA binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008289"(lipid binding)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0045296"(cadherin binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048156"(tau protein binding)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030425"(dendrite)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0051646"(mitochondrion localization)|go:"GO:0061564"(axon development)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0071963"(establishment or maintenance of cell polarity regulating cell shape)|go:"GO:0097427"(microtubule bundle)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1904526"(regulation of microtubule binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001772(Kinase-associated KA1)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028375|mint:Q7KZI7|rcsb pdb:3IEC|rcsb pdb:5EAK|rcsb pdb:5KZ7|rcsb pdb:5KZ8 ensembl:ENSP00000356515|refseq:XP_011534408.1|refseq:NP_009055.2|refseq:XP_005267187.1|dip:DIP-711N|ensembl:ENSG00000152818(gene)|ensembl:ENST00000367545(transcript)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0003779"(actin binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006936"(muscle contraction)|go:"GO:0007517"(muscle organ development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016010"(dystrophin-associated glycoprotein complex)|go:"GO:0016020"(membrane)|go:"GO:0017166"(vinculin binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030175"(filopodium)|go:"GO:0031527"(filopodium membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042383"(sarcolemma)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0070062"(extracellular exosome)|go:"GO:2000649"(regulation of sodium ion transmembrane transporter activity)|interpro:IPR000433(Zinc finger, ZZ-type)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR002017(Spectrin repeat)|interpro:IPR011992(EF-Hand type)|interpro:IPR015153(EF-hand, region 1)|interpro:IPR015154(EF-hand, region 2)|interpro:IPR018159|interpro:IPR035436|interpro:IPR036020|interpro:IPR036872|interpro:IPR043145|mint:P46939|rcsb pdb:1BHD|rcsb pdb:1QAG|rcsb pdb:6M5G|reactome:R-HSA-9619665 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/09/18 rogid:yfUqSCu4bgkncBd6hRRg5pKkArc9606 rogid:metWqbqGtzonNZ1mgNjlFrenuI89606 intact-crc:8CC685E772E6CABB|rigid:Z4RZV/2i2psYZ5ttHMwfpjdkVOo false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q7KZI7 uniprotkb:O00193 intact:EBI-516560|uniprotkb:Q15449|uniprotkb:Q15524|uniprotkb:Q5XGA3|uniprotkb:Q68A18|uniprotkb:Q96HB3|uniprotkb:Q96RG0|ensembl:ENSP00000385751 intact:EBI-727094|uniprotkb:B2RD28|ensembl:ENSP00000228136 psi-mi:mark2_human(display_long)|uniprotkb:MAP/microtubule affinity-regulating kinase 2(gene name synonym)|uniprotkb:ELKL motif kinase 1(gene name synonym)|uniprotkb:PAR1 homolog(gene name synonym)|uniprotkb:MARK2(gene name)|psi-mi:MARK2(display_short)|uniprotkb:EMK1(gene name synonym)|uniprotkb:PAR1 homolog b(gene name synonym) psi-mi:smap_human(display_long)|uniprotkb:SMAP(gene name)|psi-mi:SMAP(display_short)|uniprotkb:C11orf58(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514724|imex:IM-12079-93 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001034558.2|refseq:NP_001156768.1|refseq:NP_001156769.1|refseq:NP_004945.4|refseq:NP_059672.2|dip:DIP-31321N|ensembl:ENSG00000072518(gene)|ensembl:ENST00000402010(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0001764"(neuron migration)|go:"GO:0003723"(RNA binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008289"(lipid binding)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0045296"(cadherin binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048156"(tau protein binding)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030425"(dendrite)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0051646"(mitochondrion localization)|go:"GO:0061564"(axon development)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0071963"(establishment or maintenance of cell polarity regulating cell shape)|go:"GO:0097427"(microtubule bundle)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1904526"(regulation of microtubule binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001772(Kinase-associated KA1)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028375|mint:Q7KZI7|rcsb pdb:3IEC|rcsb pdb:5EAK|rcsb pdb:5KZ7|rcsb pdb:5KZ8 refseq:NP_055082.1|ensembl:ENSG00000110696(gene)|ensembl:ENST00000228136(transcript)|interpro:IPR026714|interpro:IPR028124 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/09/18 rogid:yfUqSCu4bgkncBd6hRRg5pKkArc9606 rogid:QS9xLHC7bRYRxDvg37iPVulqwLg9606 intact-crc:8CC685E772E6CABB|rigid:Z4RZV/2i2psYZ5ttHMwfpjdkVOo false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q7KZI7 uniprotkb:Q13425 intact:EBI-516560|uniprotkb:Q15449|uniprotkb:Q15524|uniprotkb:Q5XGA3|uniprotkb:Q68A18|uniprotkb:Q96HB3|uniprotkb:Q96RG0|ensembl:ENSP00000385751 intact:EBI-80411|ensembl:ENSP00000338191|uniprotkb:Q9BY09 psi-mi:mark2_human(display_long)|uniprotkb:MAP/microtubule affinity-regulating kinase 2(gene name synonym)|uniprotkb:ELKL motif kinase 1(gene name synonym)|uniprotkb:PAR1 homolog(gene name synonym)|uniprotkb:MARK2(gene name)|psi-mi:MARK2(display_short)|uniprotkb:EMK1(gene name synonym)|uniprotkb:PAR1 homolog b(gene name synonym) psi-mi:sntb2_human(display_long)|uniprotkb:SNT2B2(gene name synonym)|uniprotkb:SNTB2(gene name)|psi-mi:SNTB2(display_short)|uniprotkb:D16S2531E(gene name synonym)|uniprotkb:SNTL(gene name synonym)|uniprotkb:59 kDa dystrophin-associated protein A1 basic component 2(gene name synonym)|uniprotkb:Syntrophin-3(gene name synonym)|uniprotkb:Syntrophin-like(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514724|imex:IM-12079-93 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001034558.2|refseq:NP_001156768.1|refseq:NP_001156769.1|refseq:NP_004945.4|refseq:NP_059672.2|dip:DIP-31321N|ensembl:ENSG00000072518(gene)|ensembl:ENST00000402010(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0001764"(neuron migration)|go:"GO:0003723"(RNA binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008289"(lipid binding)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0045296"(cadherin binding)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048156"(tau protein binding)|go:"GO:0050321"(tau-protein kinase activity)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030425"(dendrite)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0051646"(mitochondrion localization)|go:"GO:0061564"(axon development)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0071963"(establishment or maintenance of cell polarity regulating cell shape)|go:"GO:0097427"(microtubule bundle)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1904526"(regulation of microtubule binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001772(Kinase-associated KA1)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR028375|mint:Q7KZI7|rcsb pdb:3IEC|rcsb pdb:5EAK|rcsb pdb:5KZ7|rcsb pdb:5KZ8 go:"GO:0016010"(dystrophin-associated glycoprotein complex)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005874"(microtubule)|go:"GO:0016020"(membrane)|go:"GO:0030658"(transport vesicle membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045202"(synapse)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR015482(Syntrophin)|interpro:IPR028550|interpro:IPR036034|interpro:IPR041428|mint:Q13425|rcsb pdb:2VRF|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|ensembl:ENSG00000168807(gene)|ensembl:ENST00000336278(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|refseq:NP_006741.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/09/18 rogid:yfUqSCu4bgkncBd6hRRg5pKkArc9606 rogid:SABgmvArdLH93OpFobs/L3BleVY9606 intact-crc:8CC685E772E6CABB|rigid:Z4RZV/2i2psYZ5ttHMwfpjdkVOo false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96SU4 uniprotkb:Q96EV8 intact:EBI-2511368|ensembl:ENSP00000407168|uniprotkb:Q6IA67|uniprotkb:Q9H9X2|uniprotkb:Q96SK4|uniprotkb:B1AKJ8|uniprotkb:Q5TFC0|uniprotkb:Q8NB17|uniprotkb:Q8TAS8|uniprotkb:D3DQ31|uniprotkb:B3KPQ4|uniprotkb:Q86YQ3 intact:EBI-465804|uniprotkb:Q5THY3|uniprotkb:Q5THY4|uniprotkb:Q96NV2|intact:EBI-28986386|ensembl:ENSP00000341680|uniprotkb:Q9H0U2|uniprotkb:Q9H3J5|uniprotkb:A8K3V3 psi-mi:osbl9_human(display_long)|uniprotkb:OSBPL9(gene name)|psi-mi:OSBPL9(display_short)|uniprotkb:ORP9(gene name synonym)|uniprotkb:OSBP4(gene name synonym) psi-mi:dtbp1_human(display_long)|uniprotkb:My031(orf name)|uniprotkb:DTNBP1(gene name)|psi-mi:DTNBP1(display_short)|uniprotkb:Dystrobrevin-binding protein 1(gene name synonym)|uniprotkb:Hermansky-Pudlak syndrome 7 protein(gene name synonym)|uniprotkb:Dysbindin-1(gene name synonym)|uniprotkb:BLOC1S8(gene name synonym)|uniprotkb:Biogenesis of lysosome-related organelles complex 1 subunit 8(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514776|imex:IM-12079-43 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000117859(gene)|ensembl:ENST00000428468(transcript)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006699"(bile acid biosynthetic process)|go:"GO:0015248"(sterol transporter activity)|go:"GO:0016020"(membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032934"(sterol binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR000648(Oxysterol-binding protein)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR018494|interpro:IPR037239|mint:Q96SU4|reactome:R-HSA-192105|refseq:XP_011538905.1|refseq:XP_011538906.1|refseq:NP_078862.4|refseq:NP_683702.1|refseq:NP_683703.1|refseq:NP_683705.1|refseq:NP_683706.3|refseq:NP_683704.2|refseq:NP_683707.3|refseq:XP_006710386.1|refseq:XP_006710387.1|refseq:XP_006710388.1|refseq:XP_006710389.1|refseq:NP_001317509.1|refseq:XP_016855708.1|refseq:XP_016855709.1|refseq:XP_016855710.1 ensembl:ENSG00000047579(gene)|ensembl:ENST00000344537(transcript)|go:"GO:0001956"(positive regulation of neurotransmitter secretion)|go:"GO:0005634"(nucleus)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007596"(blood coagulation)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0010008"(endosome membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016528"(sarcoplasm)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0030496"(midbody)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031083"(BLOC-1 complex)|go:"GO:0031175"(neuron projection development)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032438"(melanosome organization)|go:"GO:0033162"(melanosome membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0043005"(neuron projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0005737"(cytoplasm)|go:"GO:0043506"(regulation of JUN kinase activity)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0060155"(platelet dense granule organization)|go:"GO:0060159"(regulation of dopamine receptor signaling pathway)|go:"GO:0071901"(negative regulation of protein serine/threonine kinase activity)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1904115"(axon cytoplasm)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR007531(Dysbindin)|reactome:R-HSA-432722|go:"GO:0048490"(anterograde synaptic vesicle transport)|refseq:NP_115498.2|refseq:NP_898861.1|refseq:NP_001258597.1|refseq:NP_001258598.1|ensembl:ENST00000338950|ensembl:ENSP00000344718|ensembl:ENSP00000341680|refseq:NP_001258596.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2017/12/08 rogid:2XLQ0JD4BEKGoyiwd/63YTmyVlE9606 rogid:PBwxp1vobm9l5yGoqev97lzkMHg9606 intact-crc:953A7A7057E6D536|rigid:NzM7TYgZGZPfsJ+Tv9JQdGYcwlE false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96SU4 uniprotkb:Q99880 intact:EBI-2511368|ensembl:ENSP00000407168|uniprotkb:Q6IA67|uniprotkb:Q9H9X2|uniprotkb:Q96SK4|uniprotkb:B1AKJ8|uniprotkb:Q5TFC0|uniprotkb:Q8NB17|uniprotkb:Q8TAS8|uniprotkb:D3DQ31|uniprotkb:B3KPQ4|uniprotkb:Q86YQ3 intact:EBI-1237119|uniprotkb:Q52LW9|uniprotkb:B2R5A3|ensembl:ENSP00000366618 psi-mi:osbl9_human(display_long)|uniprotkb:OSBPL9(gene name)|psi-mi:OSBPL9(display_short)|uniprotkb:ORP9(gene name synonym)|uniprotkb:OSBP4(gene name synonym) psi-mi:h2b1l_human(display_long)|uniprotkb:H2BC13(gene name)|psi-mi:H2BC13(display_short)|uniprotkb:H2BFC(gene name synonym)|uniprotkb:HIST1H2BL(gene name synonym)|uniprotkb:Histone H2B.c(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514776|imex:IM-12079-43 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000117859(gene)|ensembl:ENST00000428468(transcript)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006699"(bile acid biosynthetic process)|go:"GO:0015248"(sterol transporter activity)|go:"GO:0016020"(membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032934"(sterol binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR000648(Oxysterol-binding protein)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR018494|interpro:IPR037239|mint:Q96SU4|reactome:R-HSA-192105|refseq:XP_011538905.1|refseq:XP_011538906.1|refseq:NP_078862.4|refseq:NP_683702.1|refseq:NP_683703.1|refseq:NP_683705.1|refseq:NP_683706.3|refseq:NP_683704.2|refseq:NP_683707.3|refseq:XP_006710386.1|refseq:XP_006710387.1|refseq:XP_006710388.1|refseq:XP_006710389.1|refseq:NP_001317509.1|refseq:XP_016855708.1|refseq:XP_016855709.1|refseq:XP_016855710.1 refseq:NP_003510.1|dip:DIP-38154N|interpro:IPR000558(Histone H2B)|interpro:IPR007125(Histone core)|ensembl:ENSG00000185130(gene)|ensembl:ENST00000377401(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0070062"(extracellular exosome)|reactome:R-HSA-110328|reactome:R-HSA-110329|reactome:R-HSA-110330|reactome:R-HSA-110331|reactome:R-HSA-1221632|interpro:IPR009072(Histone-fold)|reactome:R-HSA-171306|reactome:R-HSA-1912408|reactome:R-HSA-201722|reactome:R-HSA-212300|reactome:R-HSA-2299718|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559586|reactome:R-HSA-3214815|reactome:R-HSA-3214847|reactome:R-HSA-427359|reactome:R-HSA-427389|reactome:R-HSA-427413|reactome:R-HSA-5334118|reactome:R-HSA-5578749|reactome:R-HSA-5617472|reactome:R-HSA-5250924|reactome:R-HSA-5625886|reactome:R-HSA-5689880|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-606279|reactome:R-HSA-69473|reactome:R-HSA-73728|reactome:R-HSA-73772|reactome:R-HSA-8866654|reactome:R-HSA-8936459|reactome:R-HSA-8939236|reactome:R-HSA-9018519|reactome:R-HSA-912446|reactome:R-HSA-9609690|reactome:R-HSA-9610379|reactome:R-HSA-9616222|reactome:R-HSA-9670095|reactome:R-HSA-9710421|reactome:R-HSA-977225 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2017/12/08 rogid:2XLQ0JD4BEKGoyiwd/63YTmyVlE9606 rogid:vVD3xoHavMKCopzEez7zarZBKFc9606 intact-crc:953A7A7057E6D536|rigid:NzM7TYgZGZPfsJ+Tv9JQdGYcwlE false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96SU4 uniprotkb:P30793 intact:EBI-2511368|ensembl:ENSP00000407168|uniprotkb:Q6IA67|uniprotkb:Q9H9X2|uniprotkb:Q96SK4|uniprotkb:B1AKJ8|uniprotkb:Q5TFC0|uniprotkb:Q8NB17|uniprotkb:Q8TAS8|uniprotkb:D3DQ31|uniprotkb:B3KPQ4|uniprotkb:Q86YQ3 intact:EBI-958183|uniprotkb:Q9Y4I8|ensembl:ENSP00000378890|ensembl:ENSP00000419045|uniprotkb:Q6FHY7 psi-mi:osbl9_human(display_long)|uniprotkb:OSBPL9(gene name)|psi-mi:OSBPL9(display_short)|uniprotkb:ORP9(gene name synonym)|uniprotkb:OSBP4(gene name synonym) psi-mi:gch1_human(display_long)|uniprotkb:GCH1(gene name)|psi-mi:GCH1(display_short)|uniprotkb:DYT5(gene name synonym)|uniprotkb:GCH(gene name synonym)|uniprotkb:GTP cyclohydrolase I(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514776|imex:IM-12079-43 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000117859(gene)|ensembl:ENST00000428468(transcript)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006699"(bile acid biosynthetic process)|go:"GO:0015248"(sterol transporter activity)|go:"GO:0016020"(membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032934"(sterol binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR000648(Oxysterol-binding protein)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR018494|interpro:IPR037239|mint:Q96SU4|reactome:R-HSA-192105|refseq:XP_011538905.1|refseq:XP_011538906.1|refseq:NP_078862.4|refseq:NP_683702.1|refseq:NP_683703.1|refseq:NP_683705.1|refseq:NP_683706.3|refseq:NP_683704.2|refseq:NP_683707.3|refseq:XP_006710386.1|refseq:XP_006710387.1|refseq:XP_006710388.1|refseq:XP_006710389.1|refseq:NP_001317509.1|refseq:XP_016855708.1|refseq:XP_016855709.1|refseq:XP_016855710.1 ensembl:ENSG00000131979(gene)|ensembl:ENST00000395514(transcript)|ensembl:ENST00000491895(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0003934"(GTP cyclohydrolase I activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006809"(nitric oxide biosynthetic process)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0006729"(tetrahydrobiopterin biosynthetic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010460"(positive regulation of heart rate)|go:"GO:0014916"(regulation of lung blood pressure)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0035998"(7,8-dihydroneopterin 3'-triphosphate biosynthetic process)|go:"GO:0042311"(vasodilation)|go:"GO:0042416"(dopamine biosynthetic process)|go:"GO:0042559"(pteridine-containing compound biosynthetic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0046654"(tetrahydrofolate biosynthetic process)|go:"GO:0048265"(response to pain)|go:"GO:0050884"(neuromuscular process controlling posture)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:2000121"(regulation of removal of superoxide radicals)|interpro:IPR001474(GTP cyclohydrolase I)|interpro:IPR018234|interpro:IPR020602|interpro:IPR043133|interpro:IPR043134|rcsb pdb:1FB1|rcsb pdb:6Z80|rcsb pdb:6Z85|rcsb pdb:6Z86|rcsb pdb:6Z87|rcsb pdb:6Z88|rcsb pdb:6Z89|reactome:R-HSA-1474151|refseq:NP_000152.1|refseq:NP_001019195.1|refseq:NP_001019241.1|refseq:NP_001019242.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2017/12/08 rogid:2XLQ0JD4BEKGoyiwd/63YTmyVlE9606 rogid:9z/ipW7g2/eM/he2GvH8TndDK9I9606 intact-crc:953A7A7057E6D536|rigid:NzM7TYgZGZPfsJ+Tv9JQdGYcwlE false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96SU4 uniprotkb:Q96CS2 intact:EBI-2511368|ensembl:ENSP00000407168|uniprotkb:Q6IA67|uniprotkb:Q9H9X2|uniprotkb:Q96SK4|uniprotkb:B1AKJ8|uniprotkb:Q5TFC0|uniprotkb:Q8NB17|uniprotkb:Q8TAS8|uniprotkb:D3DQ31|uniprotkb:B3KPQ4|uniprotkb:Q86YQ3 intact:EBI-2514791|ensembl:ENSP00000282058|uniprotkb:Q8N837|uniprotkb:B2RDM7 psi-mi:osbl9_human(display_long)|uniprotkb:OSBPL9(gene name)|psi-mi:OSBPL9(display_short)|uniprotkb:ORP9(gene name synonym)|uniprotkb:OSBP4(gene name synonym) psi-mi:haus1_human(display_long)|uniprotkb:HAUS1(gene name)|psi-mi:HAUS1(display_short)|uniprotkb:CCDC5(gene name synonym)|uniprotkb:HEIC(gene name synonym)|uniprotkb:Coiled-coil domain-containing protein 5(gene name synonym)|uniprotkb:Enhancer of invasion-cluster(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514776|imex:IM-12079-43 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000117859(gene)|ensembl:ENST00000428468(transcript)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006699"(bile acid biosynthetic process)|go:"GO:0015248"(sterol transporter activity)|go:"GO:0016020"(membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032934"(sterol binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR000648(Oxysterol-binding protein)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR018494|interpro:IPR037239|mint:Q96SU4|reactome:R-HSA-192105|refseq:XP_011538905.1|refseq:XP_011538906.1|refseq:NP_078862.4|refseq:NP_683702.1|refseq:NP_683703.1|refseq:NP_683705.1|refseq:NP_683706.3|refseq:NP_683704.2|refseq:NP_683707.3|refseq:XP_006710386.1|refseq:XP_006710387.1|refseq:XP_006710388.1|refseq:XP_006710389.1|refseq:NP_001317509.1|refseq:XP_016855708.1|refseq:XP_016855709.1|refseq:XP_016855710.1 ensembl:ENSG00000152240(gene)|ensembl:ENST00000282058(transcript)|go:"GO:0000922"(spindle pole)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0007098"(centrosome cycle)|go:"GO:0051225"(spindle assembly)|go:"GO:0051301"(cell division)|go:"GO:0070652"(HAUS complex)|go:"GO:1990498"(mitotic spindle microtubule)|interpro:IPR026243|mint:Q96CS2|reactome:R-HSA-2565942|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-8854518|refseq:NP_612452.1|dip:DIP-48835N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2017/12/08 rogid:2XLQ0JD4BEKGoyiwd/63YTmyVlE9606 rogid:U+lgSilH3iBIHBktPv30KtUnDPg9606 intact-crc:953A7A7057E6D536|rigid:NzM7TYgZGZPfsJ+Tv9JQdGYcwlE false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96SU4 uniprotkb:Q86V97 intact:EBI-2511368|ensembl:ENSP00000407168|uniprotkb:Q6IA67|uniprotkb:Q9H9X2|uniprotkb:Q96SK4|uniprotkb:B1AKJ8|uniprotkb:Q5TFC0|uniprotkb:Q8NB17|uniprotkb:Q8TAS8|uniprotkb:D3DQ31|uniprotkb:B3KPQ4|uniprotkb:Q86YQ3 intact:EBI-2514778|ensembl:ENSP00000368799|uniprotkb:Q96MP6|uniprotkb:Q8NDM5|uniprotkb:Q5T6Y8|uniprotkb:Q8N8L0 psi-mi:osbl9_human(display_long)|uniprotkb:OSBPL9(gene name)|psi-mi:OSBPL9(display_short)|uniprotkb:ORP9(gene name synonym)|uniprotkb:OSBP4(gene name synonym) psi-mi:kbtb6_human(display_long)|uniprotkb:KBTBD6(gene name)|psi-mi:KBTBD6(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514776|imex:IM-12079-43 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000117859(gene)|ensembl:ENST00000428468(transcript)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006699"(bile acid biosynthetic process)|go:"GO:0015248"(sterol transporter activity)|go:"GO:0016020"(membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032934"(sterol binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR000648(Oxysterol-binding protein)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR018494|interpro:IPR037239|mint:Q96SU4|reactome:R-HSA-192105|refseq:XP_011538905.1|refseq:XP_011538906.1|refseq:NP_078862.4|refseq:NP_683702.1|refseq:NP_683703.1|refseq:NP_683705.1|refseq:NP_683706.3|refseq:NP_683704.2|refseq:NP_683707.3|refseq:XP_006710386.1|refseq:XP_006710387.1|refseq:XP_006710388.1|refseq:XP_006710389.1|refseq:NP_001317509.1|refseq:XP_016855708.1|refseq:XP_016855709.1|refseq:XP_016855710.1 ensembl:ENSG00000165572(gene)|ensembl:ENST00000379485(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0035020"(regulation of Rac protein signal transduction)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0070936"(protein K48-linked ubiquitination)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR011705(BTB/Kelch-associated)|interpro:IPR015915(Kelch-type beta propeller)|interpro:IPR017096(Kelch-like protein, gigaxonin)|reactome:R-HSA-8951664|reactome:R-HSA-983168|rcsb pdb:4XC2|refseq:NP_690867.3 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2017/12/08 rogid:2XLQ0JD4BEKGoyiwd/63YTmyVlE9606 rogid:iMugkQiayHqkx3aiExLs32a5Bv49606 intact-crc:953A7A7057E6D536|rigid:NzM7TYgZGZPfsJ+Tv9JQdGYcwlE false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96SU4 uniprotkb:Q96SU4 intact:EBI-2511368|ensembl:ENSP00000407168|uniprotkb:Q6IA67|uniprotkb:Q9H9X2|uniprotkb:Q96SK4|uniprotkb:B1AKJ8|uniprotkb:Q5TFC0|uniprotkb:Q8NB17|uniprotkb:Q8TAS8|uniprotkb:D3DQ31|uniprotkb:B3KPQ4|uniprotkb:Q86YQ3 intact:EBI-2511368|ensembl:ENSP00000407168|uniprotkb:Q6IA67|uniprotkb:Q9H9X2|uniprotkb:Q96SK4|uniprotkb:B1AKJ8|uniprotkb:Q5TFC0|uniprotkb:Q8NB17|uniprotkb:Q8TAS8|uniprotkb:D3DQ31|uniprotkb:B3KPQ4|uniprotkb:Q86YQ3 psi-mi:osbl9_human(display_long)|uniprotkb:OSBPL9(gene name)|psi-mi:OSBPL9(display_short)|uniprotkb:ORP9(gene name synonym)|uniprotkb:OSBP4(gene name synonym) psi-mi:osbl9_human(display_long)|uniprotkb:OSBPL9(gene name)|psi-mi:OSBPL9(display_short)|uniprotkb:ORP9(gene name synonym)|uniprotkb:OSBP4(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514776|imex:IM-12079-43 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000117859(gene)|ensembl:ENST00000428468(transcript)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006699"(bile acid biosynthetic process)|go:"GO:0015248"(sterol transporter activity)|go:"GO:0016020"(membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032934"(sterol binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR000648(Oxysterol-binding protein)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR018494|interpro:IPR037239|mint:Q96SU4|reactome:R-HSA-192105|refseq:XP_011538905.1|refseq:XP_011538906.1|refseq:NP_078862.4|refseq:NP_683702.1|refseq:NP_683703.1|refseq:NP_683705.1|refseq:NP_683706.3|refseq:NP_683704.2|refseq:NP_683707.3|refseq:XP_006710386.1|refseq:XP_006710387.1|refseq:XP_006710388.1|refseq:XP_006710389.1|refseq:NP_001317509.1|refseq:XP_016855708.1|refseq:XP_016855709.1|refseq:XP_016855710.1 ensembl:ENSG00000117859(gene)|ensembl:ENST00000428468(transcript)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006699"(bile acid biosynthetic process)|go:"GO:0015248"(sterol transporter activity)|go:"GO:0016020"(membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032934"(sterol binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR000648(Oxysterol-binding protein)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR018494|interpro:IPR037239|mint:Q96SU4|reactome:R-HSA-192105|refseq:XP_011538905.1|refseq:XP_011538906.1|refseq:NP_078862.4|refseq:NP_683702.1|refseq:NP_683703.1|refseq:NP_683705.1|refseq:NP_683706.3|refseq:NP_683704.2|refseq:NP_683707.3|refseq:XP_006710386.1|refseq:XP_006710387.1|refseq:XP_006710388.1|refseq:XP_006710389.1|refseq:NP_001317509.1|refseq:XP_016855708.1|refseq:XP_016855709.1|refseq:XP_016855710.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2017/12/08 rogid:2XLQ0JD4BEKGoyiwd/63YTmyVlE9606 rogid:2XLQ0JD4BEKGoyiwd/63YTmyVlE9606 intact-crc:953A7A7057E6D536|rigid:NzM7TYgZGZPfsJ+Tv9JQdGYcwlE false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96SU4 uniprotkb:Q6QNY1 intact:EBI-2511368|ensembl:ENSP00000407168|uniprotkb:Q6IA67|uniprotkb:Q9H9X2|uniprotkb:Q96SK4|uniprotkb:B1AKJ8|uniprotkb:Q5TFC0|uniprotkb:Q8NB17|uniprotkb:Q8TAS8|uniprotkb:D3DQ31|uniprotkb:B3KPQ4|uniprotkb:Q86YQ3 intact:EBI-465872|ensembl:ENSP00000359398|uniprotkb:Q5W040|uniprotkb:Q8WUI8|uniprotkb:B4DQV2 psi-mi:osbl9_human(display_long)|uniprotkb:OSBPL9(gene name)|psi-mi:OSBPL9(display_short)|uniprotkb:ORP9(gene name synonym)|uniprotkb:OSBP4(gene name synonym) psi-mi:bl1s2_human(display_long)|uniprotkb:BLOC1S2(gene name)|psi-mi:BLOC1S2(display_short)|uniprotkb:BLOS2(gene name synonym)|uniprotkb:CEAP(gene name synonym)|uniprotkb:Centrosome-associated protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514776|imex:IM-12079-43 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000117859(gene)|ensembl:ENST00000428468(transcript)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006699"(bile acid biosynthetic process)|go:"GO:0015248"(sterol transporter activity)|go:"GO:0016020"(membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032934"(sterol binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR000648(Oxysterol-binding protein)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR018494|interpro:IPR037239|mint:Q96SU4|reactome:R-HSA-192105|refseq:XP_011538905.1|refseq:XP_011538906.1|refseq:NP_078862.4|refseq:NP_683702.1|refseq:NP_683703.1|refseq:NP_683705.1|refseq:NP_683706.3|refseq:NP_683704.2|refseq:NP_683707.3|refseq:XP_006710386.1|refseq:XP_006710387.1|refseq:XP_006710388.1|refseq:XP_006710389.1|refseq:NP_001317509.1|refseq:XP_016855708.1|refseq:XP_016855709.1|refseq:XP_016855710.1 go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0016197"(endosomal transport)|go:"GO:0031083"(BLOC-1 complex)|go:"GO:0031175"(neuron projection development)|ensembl:ENSG00000196072(gene)|go:"GO:0032418"(lysosome localization)|ensembl:ENST00000370372(transcript)|go:"GO:0032438"(melanosome organization)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0000930"(gamma-tubulin complex)|go:"GO:0005634"(nucleus)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048490"(anterograde synaptic vesicle transport)|go:"GO:0060155"(platelet dense granule organization)|go:"GO:0097345"(mitochondrial outer membrane permeabilization)|go:"GO:0099078"(BORC complex)|go:"GO:1904115"(axon cytoplasm)|interpro:IPR019269|go:"GO:0005739"(mitochondrion)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005813"(centrosome)|go:"GO:0007020"(microtubule nucleation)|go:"GO:0008022"(protein C-terminus binding)|refseq:NP_776170.2|refseq:NP_001001342.1|refseq:NP_001269366.1|refseq:NP_001269367.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2017/12/08 rogid:2XLQ0JD4BEKGoyiwd/63YTmyVlE9606 rogid:UFYvRoJEOtMQZa5OEOCt2gHLOm89606 intact-crc:953A7A7057E6D536|rigid:NzM7TYgZGZPfsJ+Tv9JQdGYcwlE false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96SU4 uniprotkb:Q9P2S5 intact:EBI-2511368|ensembl:ENSP00000407168|uniprotkb:Q6IA67|uniprotkb:Q9H9X2|uniprotkb:Q96SK4|uniprotkb:B1AKJ8|uniprotkb:Q5TFC0|uniprotkb:Q8NB17|uniprotkb:Q8TAS8|uniprotkb:D3DQ31|uniprotkb:B3KPQ4|uniprotkb:Q86YQ3 intact:EBI-1054904|uniprotkb:Q5T0D6|uniprotkb:Q9BUH7|uniprotkb:Q9NTK7|uniprotkb:Q9NX56|ensembl:ENSP00000270708 psi-mi:osbl9_human(display_long)|uniprotkb:OSBPL9(gene name)|psi-mi:OSBPL9(display_short)|uniprotkb:ORP9(gene name synonym)|uniprotkb:OSBP4(gene name synonym) psi-mi:wrp73_human(display_long)|uniprotkb:WRAP73(gene name)|psi-mi:WRAP73(display_short)|uniprotkb:WDR8(gene name synonym)|uniprotkb:WD repeat-containing protein 8(gene name synonym)|uniprotkb:WD repeat-containing protein antisense to TP73 gene(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514776|imex:IM-12079-43 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000117859(gene)|ensembl:ENST00000428468(transcript)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006699"(bile acid biosynthetic process)|go:"GO:0015248"(sterol transporter activity)|go:"GO:0016020"(membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032934"(sterol binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR000648(Oxysterol-binding protein)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR018494|interpro:IPR037239|mint:Q96SU4|reactome:R-HSA-192105|refseq:XP_011538905.1|refseq:XP_011538906.1|refseq:NP_078862.4|refseq:NP_683702.1|refseq:NP_683703.1|refseq:NP_683705.1|refseq:NP_683706.3|refseq:NP_683704.2|refseq:NP_683707.3|refseq:XP_006710386.1|refseq:XP_006710387.1|refseq:XP_006710388.1|refseq:XP_006710389.1|refseq:NP_001317509.1|refseq:XP_016855708.1|refseq:XP_016855709.1|refseq:XP_016855710.1 refseq:NP_060288.3|ensembl:ENSG00000116213(gene)|ensembl:ENST00000270708(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0030030"(cell projection organization)|go:"GO:0036064"(ciliary basal body)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:1902440"(protein localization to mitotic spindle pole body)|go:"GO:1902857"(positive regulation of non-motile cilium assembly)|go:"GO:1990811"(MWP complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|mint:Q9P2S5 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2017/12/08 rogid:2XLQ0JD4BEKGoyiwd/63YTmyVlE9606 rogid:H5LC0HbUA2MqmXzFg7y256KDg2U9606 intact-crc:953A7A7057E6D536|rigid:NzM7TYgZGZPfsJ+Tv9JQdGYcwlE false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96SU4 uniprotkb:O95292 intact:EBI-2511368|ensembl:ENSP00000407168|uniprotkb:Q6IA67|uniprotkb:Q9H9X2|uniprotkb:Q96SK4|uniprotkb:B1AKJ8|uniprotkb:Q5TFC0|uniprotkb:Q8NB17|uniprotkb:Q8TAS8|uniprotkb:D3DQ31|uniprotkb:B3KPQ4|uniprotkb:Q86YQ3 intact:EBI-1188298|uniprotkb:O95293|uniprotkb:Q9P0H0|uniprotkb:A2A2F2|ensembl:ENSP00000417175 psi-mi:osbl9_human(display_long)|uniprotkb:OSBPL9(gene name)|psi-mi:OSBPL9(display_short)|uniprotkb:ORP9(gene name synonym)|uniprotkb:OSBP4(gene name synonym) psi-mi:vapb_human(display_long)|uniprotkb:VAPB(gene name)|psi-mi:VAPB(display_short)|uniprotkb:UNQ484/PRO983(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514776|imex:IM-12079-43 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000117859(gene)|ensembl:ENST00000428468(transcript)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006699"(bile acid biosynthetic process)|go:"GO:0015248"(sterol transporter activity)|go:"GO:0016020"(membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032934"(sterol binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR000648(Oxysterol-binding protein)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR018494|interpro:IPR037239|mint:Q96SU4|reactome:R-HSA-192105|refseq:XP_011538905.1|refseq:XP_011538906.1|refseq:NP_078862.4|refseq:NP_683702.1|refseq:NP_683703.1|refseq:NP_683705.1|refseq:NP_683706.3|refseq:NP_683704.2|refseq:NP_683707.3|refseq:XP_006710386.1|refseq:XP_006710387.1|refseq:XP_006710388.1|refseq:XP_006710389.1|refseq:NP_001317509.1|refseq:XP_016855708.1|refseq:XP_016855709.1|refseq:XP_016855710.1 refseq:NP_001182606.1|refseq:NP_004729.1|ensembl:ENSG00000124164(gene)|ensembl:ENST00000475243(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0008017"(microtubule binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019048"(modulation by virus of host process)|go:"GO:0019899"(enzyme binding)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0033149"(FFAT motif binding)|go:"GO:0036498"(IRE1-mediated unfolded protein response)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044790"(suppression of viral release by host)|go:"GO:0044791"(obsolete positive regulation by host of viral release from host cell)|go:"GO:0044828"(negative regulation by host of viral genome replication)|go:"GO:0044829"(positive regulation by host of viral genome replication)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0045296"(cadherin binding)|go:"GO:0046725"(negative regulation by virus of viral protein levels in host cell)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0061817"(endoplasmic reticulum-plasma membrane tethering)|go:"GO:0090114"(COPII-coated vesicle budding)|go:"GO:0090158"(endoplasmic reticulum membrane organization)|interpro:IPR000535(Major sperm protein)|interpro:IPR008962(PapD-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016763(Vesicle-associated membrane protein)|mint:O95292|rcsb pdb:2MDK|rcsb pdb:3IKK|reactome:R-HSA-1660661|reactome:R-HSA-8980692|reactome:R-HSA-9013106|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013408|dip:DIP-39816N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2017/12/08 rogid:2XLQ0JD4BEKGoyiwd/63YTmyVlE9606 rogid:+TuApjAmnGF1UZonXIsrPaIN4Ak9606 intact-crc:953A7A7057E6D536|rigid:NzM7TYgZGZPfsJ+Tv9JQdGYcwlE false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96SU4 uniprotkb:Q9BXB5 intact:EBI-2511368|ensembl:ENSP00000407168|uniprotkb:Q6IA67|uniprotkb:Q9H9X2|uniprotkb:Q96SK4|uniprotkb:B1AKJ8|uniprotkb:Q5TFC0|uniprotkb:Q8NB17|uniprotkb:Q8TAS8|uniprotkb:D3DQ31|uniprotkb:B3KPQ4|uniprotkb:Q86YQ3 intact:EBI-2511286|ensembl:ENSP00000379804|uniprotkb:Q9BTU5|uniprotkb:B4E212 psi-mi:osbl9_human(display_long)|uniprotkb:OSBPL9(gene name)|psi-mi:OSBPL9(display_short)|uniprotkb:ORP9(gene name synonym)|uniprotkb:OSBP4(gene name synonym) psi-mi:osb10_human(display_long)|uniprotkb:OSBPL10(gene name)|psi-mi:OSBPL10(display_short)|uniprotkb:ORP10(gene name synonym)|uniprotkb:OSBP9(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514776|imex:IM-12079-43 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000117859(gene)|ensembl:ENST00000428468(transcript)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006699"(bile acid biosynthetic process)|go:"GO:0015248"(sterol transporter activity)|go:"GO:0016020"(membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032934"(sterol binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR000648(Oxysterol-binding protein)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR018494|interpro:IPR037239|mint:Q96SU4|reactome:R-HSA-192105|refseq:XP_011538905.1|refseq:XP_011538906.1|refseq:NP_078862.4|refseq:NP_683702.1|refseq:NP_683703.1|refseq:NP_683705.1|refseq:NP_683706.3|refseq:NP_683704.2|refseq:NP_683707.3|refseq:XP_006710386.1|refseq:XP_006710387.1|refseq:XP_006710388.1|refseq:XP_006710389.1|refseq:NP_001317509.1|refseq:XP_016855708.1|refseq:XP_016855709.1|refseq:XP_016855710.1 ensembl:ENSG00000144645(gene)|ensembl:ENST00000396556(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005548"(phospholipid transporter activity)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0015248"(sterol transporter activity)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016020"(membrane)|go:"GO:0032934"(sterol binding)|go:"GO:0036150"(phosphatidylserine acyl-chain remodeling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR000648(Oxysterol-binding protein)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR018494|interpro:IPR037239|interpro:IPR041680|reactome:R-HSA-1482801|refseq:NP_001167531.1|refseq:NP_060254.2 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2017/12/08 rogid:2XLQ0JD4BEKGoyiwd/63YTmyVlE9606 rogid:1vbWq9QaTg7Nm56KJy7HKUoxWj49606 intact-crc:953A7A7057E6D536|rigid:NzM7TYgZGZPfsJ+Tv9JQdGYcwlE false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96SU4 uniprotkb:Q9BXB4 intact:EBI-2511368|ensembl:ENSP00000407168|uniprotkb:Q6IA67|uniprotkb:Q9H9X2|uniprotkb:Q96SK4|uniprotkb:B1AKJ8|uniprotkb:Q5TFC0|uniprotkb:Q8NB17|uniprotkb:Q8TAS8|uniprotkb:D3DQ31|uniprotkb:B3KPQ4|uniprotkb:Q86YQ3 intact:EBI-2514786|intact:EBI-28979243|ensembl:ENSP00000296220|uniprotkb:A8K9I7 psi-mi:osbl9_human(display_long)|uniprotkb:OSBPL9(gene name)|psi-mi:OSBPL9(display_short)|uniprotkb:ORP9(gene name synonym)|uniprotkb:OSBP4(gene name synonym) psi-mi:osb11_human(display_long)|uniprotkb:OSBPL11(gene name)|psi-mi:OSBPL11(display_short)|uniprotkb:ORP11(gene name synonym)|uniprotkb:OSBP12(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514776|imex:IM-12079-43 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000117859(gene)|ensembl:ENST00000428468(transcript)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006699"(bile acid biosynthetic process)|go:"GO:0015248"(sterol transporter activity)|go:"GO:0016020"(membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032934"(sterol binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR000648(Oxysterol-binding protein)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR018494|interpro:IPR037239|mint:Q96SU4|reactome:R-HSA-192105|refseq:XP_011538905.1|refseq:XP_011538906.1|refseq:NP_078862.4|refseq:NP_683702.1|refseq:NP_683703.1|refseq:NP_683705.1|refseq:NP_683706.3|refseq:NP_683704.2|refseq:NP_683707.3|refseq:XP_006710386.1|refseq:XP_006710387.1|refseq:XP_006710388.1|refseq:XP_006710389.1|refseq:NP_001317509.1|refseq:XP_016855708.1|refseq:XP_016855709.1|refseq:XP_016855710.1 ensembl:ENSG00000144909(gene)|ensembl:ENST00000296220(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0010890"(positive regulation of sequestering of triglyceride)|go:"GO:0015248"(sterol transporter activity)|go:"GO:0016020"(membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032934"(sterol binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045444"(fat cell differentiation)|interpro:IPR000648(Oxysterol-binding protein)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR018494|interpro:IPR037239|mint:Q9BXB4|rcsb pdb:2D9X|reactome:R-HSA-9013407|ensembl:ENSP00000296220|refseq:NP_073613.2 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2017/12/08 rogid:2XLQ0JD4BEKGoyiwd/63YTmyVlE9606 rogid:KkLAr8dp83zeiK8iQg61QPEm2fs9606 intact-crc:953A7A7057E6D536|rigid:NzM7TYgZGZPfsJ+Tv9JQdGYcwlE false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96SU4 uniprotkb:Q9P0L0 intact:EBI-2511368|ensembl:ENSP00000407168|uniprotkb:Q6IA67|uniprotkb:Q9H9X2|uniprotkb:Q96SK4|uniprotkb:B1AKJ8|uniprotkb:Q5TFC0|uniprotkb:Q8NB17|uniprotkb:Q8TAS8|uniprotkb:D3DQ31|uniprotkb:B3KPQ4|uniprotkb:Q86YQ3 intact:EBI-1059156|uniprotkb:Q9UBZ2|uniprotkb:O75453|uniprotkb:Q5U0E7|intact:EBI-2556404|uniprotkb:A6NDZ0|intact:EBI-2512000|uniprotkb:D3DUI3|ensembl:ENSP00000382880 psi-mi:osbl9_human(display_long)|uniprotkb:OSBPL9(gene name)|psi-mi:OSBPL9(display_short)|uniprotkb:ORP9(gene name synonym)|uniprotkb:OSBP4(gene name synonym) psi-mi:vapa_human(display_long)|uniprotkb:VAPA(gene name)|psi-mi:VAPA(display_short)|uniprotkb:VAP33(gene name synonym)|uniprotkb:33 kDa VAMP-associated protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514776|imex:IM-12079-43 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000117859(gene)|ensembl:ENST00000428468(transcript)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006699"(bile acid biosynthetic process)|go:"GO:0015248"(sterol transporter activity)|go:"GO:0016020"(membrane)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032934"(sterol binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR000648(Oxysterol-binding protein)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR018494|interpro:IPR037239|mint:Q96SU4|reactome:R-HSA-192105|refseq:XP_011538905.1|refseq:XP_011538906.1|refseq:NP_078862.4|refseq:NP_683702.1|refseq:NP_683703.1|refseq:NP_683705.1|refseq:NP_683706.3|refseq:NP_683704.2|refseq:NP_683707.3|refseq:XP_006710386.1|refseq:XP_006710387.1|refseq:XP_006710388.1|refseq:XP_006710389.1|refseq:NP_001317509.1|refseq:XP_016855708.1|refseq:XP_016855709.1|refseq:XP_016855710.1 refseq:NP_003565.4|refseq:NP_919415.2|dip:DIP-41135N|go:"GO:0031982"(vesicle)|go:"GO:0033149"(FFAT motif binding)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0044791"(obsolete positive regulation by host of viral release from host cell)|go:"GO:0044828"(negative regulation by host of viral genome replication)|go:"GO:0044829"(positive regulation by host of viral genome replication)|go:"GO:0045296"(cadherin binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0061025"(membrane fusion)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0090114"(COPII-coated vesicle budding)|interpro:IPR000535(Major sperm protein)|interpro:IPR008962(PapD-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016763(Vesicle-associated membrane protein)|mint:Q9P0L0|rcsb pdb:2RR3|rcsb pdb:6TQR|reactome:R-HSA-1660661|reactome:R-HSA-6798695|reactome:R-HSA-9609523|ensembl:ENSG00000101558(gene)|ensembl:ENST00000400000(transcript)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031175"(neuron projection development)|go:"GO:0031965"(nuclear membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0008017"(microtubule binding)|go:"GO:0008219"(cell death)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016021"(integral component of membrane) psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2017/12/08 rogid:2XLQ0JD4BEKGoyiwd/63YTmyVlE9606 rogid:h8NG5Ak0n6b/iq2yKYMsLsJKpos9606 intact-crc:953A7A7057E6D536|rigid:NzM7TYgZGZPfsJ+Tv9JQdGYcwlE false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9BXB5 uniprotkb:Q96S55 intact:EBI-2511286|ensembl:ENSP00000379804|uniprotkb:Q9BTU5|uniprotkb:B4E212 intact:EBI-2513471|ensembl:ENSP00000370150|ensembl:ENSP00000477551|uniprotkb:Q9NRJ6|uniprotkb:Q5W0E2|uniprotkb:Q53EP6|uniprotkb:Q8WV26|uniprotkb:Q5W0E4|uniprotkb:Q59ET8|uniprotkb:Q9H681|uniprotkb:B2RDB0 psi-mi:osb10_human(display_long)|uniprotkb:OSBPL10(gene name)|psi-mi:OSBPL10(display_short)|uniprotkb:ORP10(gene name synonym)|uniprotkb:OSBP9(gene name synonym) psi-mi:wrip1_human(display_long)|uniprotkb:WRNIP1(gene name)|psi-mi:WRNIP1(display_short)|uniprotkb:WHIP(gene name synonym)|uniprotkb:Werner helicase-interacting protein 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514827|imex:IM-12079-94 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000144645(gene)|ensembl:ENST00000396556(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005548"(phospholipid transporter activity)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0015248"(sterol transporter activity)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016020"(membrane)|go:"GO:0032934"(sterol binding)|go:"GO:0036150"(phosphatidylserine acyl-chain remodeling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR000648(Oxysterol-binding protein)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR018494|interpro:IPR037239|interpro:IPR041680|reactome:R-HSA-1482801|refseq:NP_001167531.1|refseq:NP_060254.2 ensembl:ENSG00000124535(gene)|ensembl:ENST00000380773(transcript)|ensembl:ENST00000618555(transcript)|go:"GO:0000731"(DNA synthesis involved in DNA repair)|go:"GO:0003677"(DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0016020"(membrane)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0030174"(regulation of DNA-dependent DNA replication initiation)|go:"GO:0042802"(identical protein binding)|go:"GO:0045087"(innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR006642(Zinc finger, Rad18-type putative)|interpro:IPR008921(DNA polymerase III clamp loader subunit, C-terminal)|interpro:IPR021886|interpro:IPR027417|interpro:IPR032423|interpro:IPR040539|mint:Q96S55|rcsb pdb:3VHS|rcsb pdb:3VHT|go:"GO:0017116"(single-stranded DNA helicase activity)|refseq:NP_064520.2|refseq:NP_569079.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:1vbWq9QaTg7Nm56KJy7HKUoxWj49606 rogid:Q8qVSqItgTO7sbWGAQ3XAoFFUr89606 intact-crc:E74BDC6212E0F549|rigid:Kjoa5d5JB35C+b9ef0aWj070oGE false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9BXB5 uniprotkb:Q13616 intact:EBI-2511286|ensembl:ENSP00000379804|uniprotkb:Q9BTU5|uniprotkb:B4E212 intact:EBI-359390|uniprotkb:O60719|uniprotkb:Q08AL6|uniprotkb:Q8IYW1|uniprotkb:D3DWG3|ensembl:ENSP00000326804|ensembl:ENSP00000387160|ensembl:ENSP00000473318|ensembl:ENSP00000499255|ensembl:ENSP00000499277|ensembl:ENSP00000499398 psi-mi:osb10_human(display_long)|uniprotkb:OSBPL10(gene name)|psi-mi:OSBPL10(display_short)|uniprotkb:ORP10(gene name synonym)|uniprotkb:OSBP9(gene name synonym) psi-mi:cul1_human(display_long)|uniprotkb:CUL1(gene name)|psi-mi:CUL1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514827|imex:IM-12079-94 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000144645(gene)|ensembl:ENST00000396556(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005548"(phospholipid transporter activity)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0015248"(sterol transporter activity)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016020"(membrane)|go:"GO:0032934"(sterol binding)|go:"GO:0036150"(phosphatidylserine acyl-chain remodeling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR000648(Oxysterol-binding protein)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR018494|interpro:IPR037239|interpro:IPR041680|reactome:R-HSA-1482801|refseq:NP_001167531.1|refseq:NP_060254.2 refseq:NP_003583.2|rcsb pdb:6WCQ|rcsb pdb:7B5L|rcsb pdb:7B5M|rcsb pdb:7B5N|rcsb pdb:7B5R|rcsb pdb:7B5S|reactome:R-HSA-1169091|reactome:R-HSA-1170546|reactome:R-HSA-174113|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-2122947|reactome:R-HSA-2565942|reactome:R-HSA-2644606|reactome:R-HSA-2644607|reactome:R-HSA-2871837|reactome:R-HSA-2894862|reactome:R-HSA-400253|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5676590|reactome:R-HSA-5684264|reactome:R-HSA-68949|reactome:R-HSA-69231|reactome:R-HSA-8854050|reactome:R-HSA-8939902|reactome:R-HSA-8951664|reactome:R-HSA-9020702|reactome:R-HSA-917937|reactome:R-HSA-9604323|reactome:R-HSA-9708530|reactome:R-HSA-983168|refseq:XP_011514931.1|refseq:XP_011514932.1|refseq:XP_011514933.1|refseq:XP_011514934.1|ensembl:ENSG00000055130(gene)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|ensembl:ENST00000325222(transcript)|ensembl:ENST00000409469(transcript)|ensembl:ENST00000602748(transcript)|ensembl:ENST00000662716(transcript)|ensembl:ENST00000663044(transcript)|ensembl:ENST00000665936(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:1990452"(Parkin-FBXW7-Cul1 ubiquitin ligase complex)|interpro:IPR001373(Cullin, N-terminal region)|interpro:IPR016157(Cullin, conserved site)|interpro:IPR016158(Cullin homology)|interpro:IPR016159(Cullin repeat-like)|interpro:IPR019559|interpro:IPR036317|interpro:IPR036388|interpro:IPR036390|mint:Q13616|rcsb pdb:1LDJ|rcsb pdb:1LDK|rcsb pdb:1U6G|rcsb pdb:3RTR|rcsb pdb:3TDU|rcsb pdb:3TDZ|rcsb pdb:4F52|rcsb pdb:4P5O|rcsb pdb:5V89|rcsb pdb:6TTU|refseq:XP_005250117.1|dip:DIP-17013N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:1vbWq9QaTg7Nm56KJy7HKUoxWj49606 rogid:OAZP+ifWW3eEnQKb937ww9s1fMQ9606 intact-crc:E74BDC6212E0F549|rigid:Kjoa5d5JB35C+b9ef0aWj070oGE false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9BXB5 uniprotkb:P63010 intact:EBI-2511286|ensembl:ENSP00000379804|uniprotkb:Q9BTU5|uniprotkb:B4E212 intact:EBI-432924|uniprotkb:A6NJP3|uniprotkb:P21851|uniprotkb:Q96J19|intact:EBI-28970775|ensembl:ENSP00000482315|intact:EBI-8011909|intact:MINT-8395045|uniprotkb:Q7Z451 psi-mi:osb10_human(display_long)|uniprotkb:OSBPL10(gene name)|psi-mi:OSBPL10(display_short)|uniprotkb:ORP10(gene name synonym)|uniprotkb:OSBP9(gene name synonym) psi-mi:ap2b1_human(display_long)|uniprotkb:AP2B1(gene name)|psi-mi:AP2B1(display_short)|uniprotkb:CLAPB1(gene name synonym)|uniprotkb:Beta-2-adaptin(gene name synonym)|uniprotkb:Beta-adaptin(gene name synonym)|uniprotkb:Plasma membrane adaptor HA2/AP2 adaptin beta subunit(gene name synonym)|uniprotkb:Clathrin assembly protein complex 2 beta large chain(gene name synonym)|uniprotkb:AP105B(gene name synonym)|uniprotkb:Adaptor protein complex AP-2 subunit beta(gene name synonym)|uniprotkb:ADTB2(gene name synonym)|uniprotkb:Adaptor-related protein complex 2 subunit beta(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514827|imex:IM-12079-94 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000144645(gene)|ensembl:ENST00000396556(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005548"(phospholipid transporter activity)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0015248"(sterol transporter activity)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016020"(membrane)|go:"GO:0032934"(sterol binding)|go:"GO:0036150"(phosphatidylserine acyl-chain remodeling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR000648(Oxysterol-binding protein)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR018494|interpro:IPR037239|interpro:IPR041680|reactome:R-HSA-1482801|refseq:NP_001167531.1|refseq:NP_060254.2 refseq:NP_001025177.1|refseq:NP_001273.1|ensembl:ENST00000610402|ensembl:ENSP00000483185|ensembl:ENST00000618940|ensembl:ENSP00000482835|ensembl:ENSP00000482315|go:"GO:0005048"(signal sequence binding)|go:"GO:0005829"(cytosol)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098884"(postsynaptic neurotransmitter receptor internalization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1905477"(positive regulation of protein localization to membrane)|interpro:IPR000225(Armadillo)|ensembl:ENSG00000006125(gene)|ensembl:ENST00000621914(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0003281"(ventricular septum development)|refseq:XP_011522757.1|go:"GO:0072583"(clathrin-dependent endocytosis)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030122"(AP-2 adaptor complex)|go:"GO:0030131"(clathrin adaptor complex)|go:"GO:0030276"(clathrin binding)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0030669"(clathrin-coated endocytic vesicle membrane)|go:"GO:0035904"(aorta development)|go:"GO:0036020"(endolysosome membrane)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0060976"(coronary vasculature development)|go:"GO:0005886"(plasma membrane)|refseq:XP_005257994.1|refseq:XP_005257995.1|refseq:XP_016879773.1|refseq:XP_016879775.1|reactome:R-HSA-416993|reactome:R-HSA-437239|reactome:R-HSA-5099900|reactome:R-HSA-5140745|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-8866427|reactome:R-HSA-8964038|reactome:R-HSA-9679191|interpro:IPR002553(Clathrin/coatomer adaptor, adaptin-like, N-terminal)|interpro:IPR008152(Clathrin adaptor, alpha/beta/gamma-adaptin, appendage, Ig-like subdomain)|interpro:IPR009028(Clathrin/coatomer adaptor, adaptin-like, appendage, C-terminal subdomain)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR012295(Beta2-adaptin/TATA-box binding, C-terminal)|interpro:IPR013037(Clathrin adaptor, beta-adaptin, appendage, Ig-like subdomain)|interpro:IPR013041(Clathrin/coatomer adaptor, adaptin-like, appendage, Ig-like subdomain)|interpro:IPR015151(Clathrin adaptor, beta-adaptin, appendage, C-terminal subdomain)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016342(Adaptor protein complex, beta subunit)|interpro:IPR026739|rcsb pdb:1E42|rcsb pdb:2G30|rcsb pdb:2IV8|rcsb pdb:2IV9|rcsb pdb:2JKR|rcsb pdb:2JKT|rcsb pdb:2VGL|rcsb pdb:2XA7|rcsb pdb:4UQI|rcsb pdb:5M5R|rcsb pdb:6QH5|rcsb pdb:6QH6|rcsb pdb:6QH7|rcsb pdb:6URI|rcsb pdb:6YAE|rcsb pdb:6YAF|rcsb pdb:6YAH|rcsb pdb:6YAI|reactome:R-HSA-167590|reactome:R-HSA-177504|reactome:R-HSA-182218|reactome:R-HSA-2132295|reactome:R-HSA-3928665|dip:DIP-33098N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:1vbWq9QaTg7Nm56KJy7HKUoxWj49606 rogid:Q5oFhdE1hcmqu7xLG3MteCu0Zcg9606 intact-crc:E74BDC6212E0F549|rigid:Kjoa5d5JB35C+b9ef0aWj070oGE false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9BXB5 uniprotkb:Q86VM9 intact:EBI-2511286|ensembl:ENSP00000379804|uniprotkb:Q9BTU5|uniprotkb:B4E212 intact:EBI-1045965|uniprotkb:Q96DG4|uniprotkb:Q96MP7|ensembl:ENSP00000301011 psi-mi:osb10_human(display_long)|uniprotkb:OSBPL10(gene name)|psi-mi:OSBPL10(display_short)|uniprotkb:ORP10(gene name synonym)|uniprotkb:OSBP9(gene name synonym) psi-mi:zch18_human(display_long)|uniprotkb:NHN1(gene name synonym)|uniprotkb:Nuclear protein NHN1(gene name synonym)|uniprotkb:ZC3H18(gene name)|psi-mi:ZC3H18(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514827|imex:IM-12079-94 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000144645(gene)|ensembl:ENST00000396556(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005548"(phospholipid transporter activity)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0015248"(sterol transporter activity)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016020"(membrane)|go:"GO:0032934"(sterol binding)|go:"GO:0036150"(phosphatidylserine acyl-chain remodeling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR000648(Oxysterol-binding protein)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR018494|interpro:IPR037239|interpro:IPR041680|reactome:R-HSA-1482801|refseq:NP_001167531.1|refseq:NP_060254.2 refseq:NP_001281269.1|ensembl:ENST00000301011(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0016607"(nuclear speck)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0046872"(metal ion binding)|go:"GO:0050779"(RNA destabilization)|go:"GO:0140262"(mRNA cap binding complex binding)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000571(Zinc finger, CCCH-type)|interpro:IPR036855|interpro:IPR041367|mint:Q86VM9|ensembl:ENSG00000158545(gene)|ensembl:ENSP00000301011|refseq:NP_653205.3 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:1vbWq9QaTg7Nm56KJy7HKUoxWj49606 rogid:H9lST8OLyCpyi5AWYqFYskL0ezI9606 intact-crc:E74BDC6212E0F549|rigid:Kjoa5d5JB35C+b9ef0aWj070oGE false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9BXB5 uniprotkb:Q9H078 intact:EBI-2511286|ensembl:ENSP00000379804|uniprotkb:Q9BTU5|uniprotkb:B4E212 intact:EBI-2107221|uniprotkb:Q8ND11|uniprotkb:Q9H8Y0|uniprotkb:B4DXW4|uniprotkb:B4DXJ7|uniprotkb:B4DXP7|uniprotkb:E7EWN6|uniprotkb:F8W7P6|ensembl:ENSP00000294053 psi-mi:osb10_human(display_long)|uniprotkb:OSBPL10(gene name)|psi-mi:OSBPL10(display_short)|uniprotkb:ORP10(gene name synonym)|uniprotkb:OSBP9(gene name synonym) psi-mi:clpb_human(display_long)|uniprotkb:CLPB(gene name)|psi-mi:CLPB(display_short)|uniprotkb:HSP78(gene name synonym)|uniprotkb:SKD3(gene name synonym)|uniprotkb:Suppressor of potassium transport defect 3(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514827|imex:IM-12079-94 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000144645(gene)|ensembl:ENST00000396556(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005548"(phospholipid transporter activity)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0015248"(sterol transporter activity)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016020"(membrane)|go:"GO:0032934"(sterol binding)|go:"GO:0036150"(phosphatidylserine acyl-chain remodeling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR000648(Oxysterol-binding protein)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR018494|interpro:IPR037239|interpro:IPR041680|reactome:R-HSA-1482801|refseq:NP_001167531.1|refseq:NP_060254.2 refseq:NP_110440.1|refseq:NP_001245321.1|refseq:NP_001245322.1|refseq:NP_001245323.1|ensembl:ENSG00000162129(gene)|ensembl:ENST00000294053(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0034605"(cellular response to heat)|go:"GO:0039529"(RIG-I signaling pathway)|go:"GO:0140374"(antiviral innate immune response)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR001270(Chaperonin clpA/B)|interpro:IPR002110(Ankyrin)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR019489|interpro:IPR020683|interpro:IPR027417|interpro:IPR036770|mint:Q9H078 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:1vbWq9QaTg7Nm56KJy7HKUoxWj49606 rogid:QqIOYOITwDC+c8kKtMGBHa/0Tjk9606 intact-crc:E74BDC6212E0F549|rigid:Kjoa5d5JB35C+b9ef0aWj070oGE false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9BXB5 uniprotkb:Q9NY33 intact:EBI-2511286|ensembl:ENSP00000379804|uniprotkb:Q9BTU5|uniprotkb:B4E212 intact:EBI-718333|ensembl:ENSP00000440502|uniprotkb:O95748|uniprotkb:Q969H2|uniprotkb:Q9BV67|uniprotkb:Q9HAL6|uniprotkb:B2RDB5|uniprotkb:B4DLX4|uniprotkb:F5H8L6 psi-mi:osb10_human(display_long)|uniprotkb:OSBPL10(gene name)|psi-mi:OSBPL10(display_short)|uniprotkb:ORP10(gene name synonym)|uniprotkb:OSBP9(gene name synonym) psi-mi:dpp3_human(display_long)|uniprotkb:Dipeptidyl peptidase III(gene name synonym)|uniprotkb:Dipeptidyl aminopeptidase III(gene name synonym)|uniprotkb:Dipeptidyl arylamidase III(gene name synonym)|uniprotkb:Enkephalinase B(gene name synonym)|uniprotkb:DPP3(gene name)|psi-mi:DPP3(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514827|imex:IM-12079-94 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000144645(gene)|ensembl:ENST00000396556(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005548"(phospholipid transporter activity)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0015248"(sterol transporter activity)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016020"(membrane)|go:"GO:0032934"(sterol binding)|go:"GO:0036150"(phosphatidylserine acyl-chain remodeling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR000648(Oxysterol-binding protein)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR018494|interpro:IPR037239|interpro:IPR041680|reactome:R-HSA-1482801|refseq:NP_001167531.1|refseq:NP_060254.2 ensembl:ENST00000541961(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0008239"(dipeptidyl-peptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0070006"(metalloaminopeptidase activity)|go:"GO:0070062"(extracellular exosome)|interpro:IPR005317(Peptidase M49, dipeptidyl-peptidase III)|interpro:IPR039461|ensembl:ENSG00000254986(gene)|rcsb pdb:3FVY|rcsb pdb:3T6B|rcsb pdb:3T6J|rcsb pdb:5E2Q|rcsb pdb:5E33|refseq:NP_005691.2|refseq:NP_569710.2|rcsb pdb:5E3A|rcsb pdb:5E3C|rcsb pdb:5EGY|rcsb pdb:5EHH|refseq:NP_001243599.1|dip:DIP-53793N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:1vbWq9QaTg7Nm56KJy7HKUoxWj49606 rogid:D47IxsTssPT5bD1CPmb2K0Z3MJQ9606 intact-crc:E74BDC6212E0F549|rigid:Kjoa5d5JB35C+b9ef0aWj070oGE false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9BXB5 uniprotkb:Q14145 intact:EBI-2511286|ensembl:ENSP00000379804|uniprotkb:Q9BTU5|uniprotkb:B4E212 intact:EBI-751001|uniprotkb:B3KPD5|uniprotkb:Q8WTX1|uniprotkb:Q6LEP0|uniprotkb:Q9BPY9|intact:EBI-28976014|ensembl:ENSP00000171111|ensembl:ENSP00000377245 psi-mi:osb10_human(display_long)|uniprotkb:OSBPL10(gene name)|psi-mi:OSBPL10(display_short)|uniprotkb:ORP10(gene name synonym)|uniprotkb:OSBP9(gene name synonym) psi-mi:keap1_human(display_long)|uniprotkb:Cytosolic inhibitor of Nrf2(gene name synonym)|uniprotkb:Kelch-like protein 19(gene name synonym)|uniprotkb:KEAP1(gene name)|psi-mi:KEAP1(display_short)|uniprotkb:INRF2(gene name synonym)|uniprotkb:KIAA0132(gene name synonym)|uniprotkb:KLHL19(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514827|imex:IM-12079-94 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000144645(gene)|ensembl:ENST00000396556(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005548"(phospholipid transporter activity)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0015248"(sterol transporter activity)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016020"(membrane)|go:"GO:0032934"(sterol binding)|go:"GO:0036150"(phosphatidylserine acyl-chain remodeling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR000648(Oxysterol-binding protein)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR018494|interpro:IPR037239|interpro:IPR041680|reactome:R-HSA-1482801|refseq:NP_001167531.1|refseq:NP_060254.2 refseq:NP_036421.2|refseq:NP_987096.1|ensembl:ENSP00000171111|ensembl:ENSP00000377245|refseq:XP_011526754.1|refseq:XP_005260230.1|refseq:XP_005260231.1|dip:DIP-42134N|ensembl:ENSG00000079999(gene)|ensembl:ENST00000171111(transcript)|ensembl:ENST00000393623(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016234"(inclusion body)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030496"(midbody)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0042802"(identical protein binding)|go:"GO:0042994"(cytoplasmic sequestering of transcription factor)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0045604"(regulation of epidermal cell differentiation)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0097718"(disordered domain specific binding)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR011705(BTB/Kelch-associated)|interpro:IPR015915(Kelch-type beta propeller)|interpro:IPR017096(Kelch-like protein, gigaxonin)|interpro:IPR030563|mint:Q14145|rcsb pdb:1U6D|rcsb pdb:1ZGK|rcsb pdb:2FLU|rcsb pdb:3VNG|rcsb pdb:3VNH|rcsb pdb:3ZGC|rcsb pdb:3ZGD|rcsb pdb:4CXI|rcsb pdb:4CXJ|rcsb pdb:4CXT|rcsb pdb:4IFJ|rcsb pdb:4IFL|rcsb pdb:4IFN|rcsb pdb:4IN4|rcsb pdb:4IQK|rcsb pdb:4L7B|rcsb pdb:4L7C|rcsb pdb:4L7D|rcsb pdb:4N1B|rcsb pdb:4XMB|rcsb pdb:5DAD|rcsb pdb:5DAF|rcsb pdb:5F72|rcsb pdb:5GIT|rcsb pdb:5NLB|rcsb pdb:5WFL|rcsb pdb:5WFV|rcsb pdb:5WG1|rcsb pdb:5WHL|rcsb pdb:5WHO|rcsb pdb:5WIY|rcsb pdb:5X54|rcsb pdb:6FFM|rcsb pdb:6FMP|rcsb pdb:6FMQ|rcsb pdb:6HWS|rcsb pdb:6LRZ|rcsb pdb:6ROG|rcsb pdb:6SP1|rcsb pdb:6SP4|rcsb pdb:6T7V|rcsb pdb:6T7Z|rcsb pdb:6TG8|rcsb pdb:6TYM|rcsb pdb:6TYP|rcsb pdb:6UF0|rcsb pdb:6W66|rcsb pdb:6W67|rcsb pdb:6W68|rcsb pdb:6W69|rcsb pdb:6WCQ|rcsb pdb:6Z6A|rcsb pdb:7K28|rcsb pdb:7K29|rcsb pdb:7K2A|rcsb pdb:7K2B|rcsb pdb:7K2C|rcsb pdb:7K2D|rcsb pdb:7K2E|rcsb pdb:7K2F|rcsb pdb:7K2G|rcsb pdb:7K2H|rcsb pdb:7K2I|rcsb pdb:7K2J|rcsb pdb:7K2K|rcsb pdb:7K2L|rcsb pdb:7K2M|rcsb pdb:7K2N|rcsb pdb:7K2O|rcsb pdb:7K2P|rcsb pdb:7K2Q|rcsb pdb:7K2R|rcsb pdb:7K2S|reactome:R-HSA-5689880|reactome:R-HSA-8932339|reactome:R-HSA-8951664|reactome:R-HSA-983168|rcsb pdb:6V6Z psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:1vbWq9QaTg7Nm56KJy7HKUoxWj49606 rogid:3y/KqnUK+5nIyjhOEfkkthmP1OA9606 intact-crc:E74BDC6212E0F549|rigid:Kjoa5d5JB35C+b9ef0aWj070oGE false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9BXB5 uniprotkb:Q9UQ35 intact:EBI-2511286|ensembl:ENSP00000379804|uniprotkb:Q9BTU5|uniprotkb:B4E212 intact:EBI-1050142|uniprotkb:A6NKB9|uniprotkb:Q9UHA8|uniprotkb:Q9UQ36|uniprotkb:Q9UQ37|uniprotkb:Q9UQ38|uniprotkb:Q9UQ40|uniprotkb:O15038|uniprotkb:O94803|uniprotkb:Q6NSL3|uniprotkb:Q6PIM3|uniprotkb:Q6PK40|uniprotkb:Q8IW17|uniprotkb:Q96GY7|uniprotkb:Q9P0G1|uniprotkb:D3DU97|ensembl:ENSP00000301740 psi-mi:osb10_human(display_long)|uniprotkb:OSBPL10(gene name)|psi-mi:OSBPL10(display_short)|uniprotkb:ORP10(gene name synonym)|uniprotkb:OSBP9(gene name synonym) psi-mi:srrm2_human(display_long)|uniprotkb:Serine/arginine-rich splicing factor-related nuclear matrix protein of 300 kDa(gene name synonym)|uniprotkb:Splicing coactivator subunit SRm300(gene name synonym)|uniprotkb:300 kDa nuclear matrix antigen(gene name synonym)|uniprotkb:SRRM2(gene name)|psi-mi:SRRM2(display_short)|uniprotkb:KIAA0324(gene name synonym)|uniprotkb:SRL300(gene name synonym)|uniprotkb:SRM300(gene name synonym)|uniprotkb:HSPC075(orf name)|uniprotkb:Tax-responsive enhancer element-binding protein 803(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514827|imex:IM-12079-94 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000144645(gene)|ensembl:ENST00000396556(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005548"(phospholipid transporter activity)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0015248"(sterol transporter activity)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016020"(membrane)|go:"GO:0032934"(sterol binding)|go:"GO:0036150"(phosphatidylserine acyl-chain remodeling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR000648(Oxysterol-binding protein)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR018494|interpro:IPR037239|interpro:IPR041680|reactome:R-HSA-1482801|refseq:NP_001167531.1|refseq:NP_060254.2 refseq:NP_057417.3|ensembl:ENSG00000167978(gene)|ensembl:ENST00000301740(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0015030"(Cajal body)|go:"GO:0016607"(nuclear speck)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0070742"(C2H2 zinc finger domain binding)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071007"(U2-type catalytic step 2 spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|interpro:IPR013170(mRNA splicing factor, Cwf21)|interpro:IPR024945|mint:Q9UQ35|rcsb pdb:5MQF|rcsb pdb:5XJC|rcsb pdb:5YZG|rcsb pdb:5Z56|rcsb pdb:5Z57|rcsb pdb:6FF4|rcsb pdb:6FF7|rcsb pdb:6ICZ|rcsb pdb:6QDV|rcsb pdb:6ZYM|rcsb pdb:7A5P|rcsb pdb:7DVQ|reactome:R-HSA-72163 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:1vbWq9QaTg7Nm56KJy7HKUoxWj49606 rogid:3yyPAOaCzKSCEg5guJSbq0MWrHI9606 intact-crc:E74BDC6212E0F549|rigid:Kjoa5d5JB35C+b9ef0aWj070oGE false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9BXB5 uniprotkb:P04075 intact:EBI-2511286|ensembl:ENSP00000379804|uniprotkb:Q9BTU5|uniprotkb:B4E212 intact:EBI-709613|uniprotkb:Q6FH76|uniprotkb:Q96B15|uniprotkb:Q9BWD9|uniprotkb:B4DXI7|uniprotkb:Q6FI10|uniprotkb:Q9UCN2|ensembl:ENSP00000400452|ensembl:ENSP00000455700|ensembl:ENSP00000455800|ensembl:ENSP00000494188 psi-mi:osb10_human(display_long)|uniprotkb:OSBPL10(gene name)|psi-mi:OSBPL10(display_short)|uniprotkb:ORP10(gene name synonym)|uniprotkb:OSBP9(gene name synonym) psi-mi:aldoa_human(display_long)|uniprotkb:Muscle-type aldolase(gene name synonym)|uniprotkb:Lung cancer antigen NY-LU-1(gene name synonym)|uniprotkb:ALDOA(gene name)|psi-mi:ALDOA(display_short)|uniprotkb:ALDA(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514827|imex:IM-12079-94 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000144645(gene)|ensembl:ENST00000396556(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005548"(phospholipid transporter activity)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0015248"(sterol transporter activity)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016020"(membrane)|go:"GO:0032934"(sterol binding)|go:"GO:0036150"(phosphatidylserine acyl-chain remodeling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR000648(Oxysterol-binding protein)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR018494|interpro:IPR037239|interpro:IPR041680|reactome:R-HSA-1482801|refseq:NP_001167531.1|refseq:NP_060254.2 refseq:NP_000025.1|refseq:NP_001121089.1|refseq:NP_001230106.1|refseq:NP_908930.1|refseq:NP_908932.1|refseq:XP_011544070.1|ensembl:ENSG00000149925(gene)|ensembl:ENST00000412304(transcript)|ensembl:ENST00000563060(transcript)|ensembl:ENST00000569545(transcript)|ensembl:ENST00000643777(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0004332"(fructose-bisphosphate aldolase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006000"(fructose metabolic process)|go:"GO:0006096"(glycolytic process)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0006941"(striated muscle contraction)|go:"GO:0007015"(actin filament organization)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0015631"(tubulin binding)|go:"GO:0016020"(membrane)|go:"GO:0030388"(fructose 1,6-bisphosphate metabolic process)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0031430"(M band)|go:"GO:0031674"(I band)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042802"(identical protein binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0061827"(sperm head)|go:"GO:0070061"(fructose binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1904724"(tertiary granule lumen)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000741(Fructose-bisphosphate aldolase, class-I)|interpro:IPR013785(Aldolase-type TIM barrel)|interpro:IPR029768|mint:P04075|rcsb pdb:1ALD|rcsb pdb:2ALD|rcsb pdb:4ALD|rcsb pdb:5KY6|reactome:R-HSA-114608|reactome:R-HSA-6798695|reactome:R-HSA-70171|reactome:R-HSA-70263 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:1vbWq9QaTg7Nm56KJy7HKUoxWj49606 rogid:/UgTtKPQj2ZyKznKIfE9OVUcDFI9606 intact-crc:E74BDC6212E0F549|rigid:Kjoa5d5JB35C+b9ef0aWj070oGE false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9BXB5 uniprotkb:Q96HS1 intact:EBI-2511286|ensembl:ENSP00000379804|uniprotkb:Q9BTU5|uniprotkb:B4E212 intact:EBI-713608|uniprotkb:Q96JB0|intact:EBI-2555528|ensembl:ENSP00000438465|uniprotkb:C9IZY7|uniprotkb:A9LN06 psi-mi:osb10_human(display_long)|uniprotkb:OSBPL10(gene name)|psi-mi:OSBPL10(display_short)|uniprotkb:ORP10(gene name synonym)|uniprotkb:OSBP9(gene name synonym) psi-mi:pgam5_human(display_long)|uniprotkb:Bcl-XL-binding protein v68(gene name synonym)|uniprotkb:PGAM5(gene name)|psi-mi:PGAM5(display_short)|uniprotkb:Phosphoglycerate mutase family member 5(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514827|imex:IM-12079-94 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000144645(gene)|ensembl:ENST00000396556(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005548"(phospholipid transporter activity)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0015248"(sterol transporter activity)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016020"(membrane)|go:"GO:0032934"(sterol binding)|go:"GO:0036150"(phosphatidylserine acyl-chain remodeling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR000648(Oxysterol-binding protein)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR018494|interpro:IPR037239|interpro:IPR041680|reactome:R-HSA-1482801|refseq:NP_001167531.1|refseq:NP_060254.2 refseq:NP_001164014.1|refseq:NP_612642.2|ensembl:ENSG00000247077(gene)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016236"(macroautophagy)|go:"GO:0016791"(phosphatase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0070266"(necroptotic process)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|interpro:IPR013078(Phosphoglycerate mutase)|interpro:IPR029033|mint:Q96HS1|rcsb pdb:3MXO|rcsb pdb:3O0T|rcsb pdb:5MUF|rcsb pdb:6CNI|rcsb pdb:6CNL|reactome:R-HSA-8934903|ensembl:ENST00000498926(transcript)|dip:DIP-50735N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:1vbWq9QaTg7Nm56KJy7HKUoxWj49606 rogid:prE0I+tNIEjN9Y1NBZbh51DY2+Q9606 intact-crc:E74BDC6212E0F549|rigid:Kjoa5d5JB35C+b9ef0aWj070oGE false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9BXB5 uniprotkb:Q14677 intact:EBI-2511286|ensembl:ENSP00000379804|uniprotkb:Q9BTU5|uniprotkb:B4E212 intact:EBI-1171113|uniprotkb:Q8NAF1|uniprotkb:Q96E05|uniprotkb:D3DQJ6|uniprotkb:B7Z6F8|intact:EBI-28971708|ensembl:ENSP00000388340 psi-mi:osb10_human(display_long)|uniprotkb:OSBPL10(gene name)|psi-mi:OSBPL10(display_short)|uniprotkb:ORP10(gene name synonym)|uniprotkb:OSBP9(gene name synonym) psi-mi:epn4_human(display_long)|uniprotkb:CLINT1(gene name)|psi-mi:CLINT1(display_short)|uniprotkb:ENTH(gene name synonym)|uniprotkb:EPN4(gene name synonym)|uniprotkb:EPNR(gene name synonym)|uniprotkb:KIAA0171(gene name synonym)|uniprotkb:Epsin-4(gene name synonym)|uniprotkb:Epsin-related protein(gene name synonym)|uniprotkb:Enthoprotin(gene name synonym)|uniprotkb:Clathrin-interacting protein localized in the trans-Golgi region(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514827|imex:IM-12079-94 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000144645(gene)|ensembl:ENST00000396556(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005548"(phospholipid transporter activity)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0015248"(sterol transporter activity)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016020"(membrane)|go:"GO:0032934"(sterol binding)|go:"GO:0036150"(phosphatidylserine acyl-chain remodeling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR000648(Oxysterol-binding protein)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR018494|interpro:IPR037239|interpro:IPR041680|reactome:R-HSA-1482801|refseq:NP_001167531.1|refseq:NP_060254.2 ensembl:ENSP00000388340|ensembl:ENST00000523094|ensembl:ENSP00000429345|ensembl:ENST00000523908|ensembl:ENSP00000429824|ensembl:ENST00000530742|ensembl:ENSP00000433419|refseq:NP_001182484.1|refseq:NP_001182485.1|refseq:NP_055481.1|ensembl:ENSG00000113282(gene)|ensembl:ENST00000411809(transcript)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006897"(endocytosis)|go:"GO:0016020"(membrane)|go:"GO:0030125"(clathrin vesicle coat)|go:"GO:0030276"(clathrin binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045296"(cadherin binding)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0048471"(perinuclear region of cytoplasm)|interpro:IPR008942(ENTH/VHS)|interpro:IPR013809(Epsin-like, N-terminal)|interpro:IPR030544|mint:Q14677|rcsb pdb:1XGW|rcsb pdb:2QY7|rcsb pdb:2V8S|reactome:R-HSA-432722|dip:DIP-45604N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:1vbWq9QaTg7Nm56KJy7HKUoxWj49606 rogid:cflzNAWnEQR6zTr4d+hwfy1doC49606 intact-crc:E74BDC6212E0F549|rigid:Kjoa5d5JB35C+b9ef0aWj070oGE false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9BXB5 uniprotkb:O00422 intact:EBI-2511286|ensembl:ENSP00000379804|uniprotkb:Q9BTU5|uniprotkb:B4E212 intact:EBI-1044156|uniprotkb:Q2TTR4|uniprotkb:Q6IAW9|uniprotkb:Q8N606|uniprotkb:Q9UF14|ensembl:ENSP00000475925|uniprotkb:B2R494|uniprotkb:X6RAL5 psi-mi:osb10_human(display_long)|uniprotkb:OSBPL10(gene name)|psi-mi:OSBPL10(display_short)|uniprotkb:ORP10(gene name synonym)|uniprotkb:OSBP9(gene name synonym) psi-mi:sap18_human(display_long)|uniprotkb:18 kDa Sin3-associated polypeptide(gene name synonym)|uniprotkb:Sin3-associated polypeptide p18(gene name synonym)|uniprotkb:Cell growth-inhibiting gene 38 protein(gene name synonym)|uniprotkb:2HOR0202(gene name synonym)|uniprotkb:SAP18(gene name)|psi-mi:SAP18(display_short)|uniprotkb:GIG38(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514827|imex:IM-12079-94 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000144645(gene)|ensembl:ENST00000396556(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005548"(phospholipid transporter activity)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0015248"(sterol transporter activity)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016020"(membrane)|go:"GO:0032934"(sterol binding)|go:"GO:0036150"(phosphatidylserine acyl-chain remodeling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR000648(Oxysterol-binding protein)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR018494|interpro:IPR037239|interpro:IPR041680|reactome:R-HSA-1482801|refseq:NP_001167531.1|refseq:NP_060254.2 ensembl:ENSG00000150459(gene)|ensembl:ENST00000607003(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048025"(negative regulation of mRNA splicing, via spliceosome)|go:"GO:0061574"(ASAP complex)|interpro:IPR010516(Sin3 associated polypeptide p18)|interpro:IPR017250(Histone deacetylase complex, SAP18 subunit)|interpro:IPR042534|mint:O00422|rcsb pdb:2HDE|reactome:R-HSA-3214815|reactome:R-HSA-427413|reactome:R-HSA-9679191|refseq:NP_005861.2|dip:DIP-33590N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:1vbWq9QaTg7Nm56KJy7HKUoxWj49606 rogid:eJoksFCc7vBoAjJEpnXJvc/yg+Q9606 intact-crc:E74BDC6212E0F549|rigid:Kjoa5d5JB35C+b9ef0aWj070oGE false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9BXB5 uniprotkb:O75323 intact:EBI-2511286|ensembl:ENSP00000379804|uniprotkb:Q9BTU5|uniprotkb:B4E212 intact:EBI-307133|uniprotkb:O43801|uniprotkb:Q53X96|uniprotkb:C9IYJ3|ensembl:ENSP00000313050 psi-mi:osb10_human(display_long)|uniprotkb:OSBPL10(gene name)|psi-mi:OSBPL10(display_short)|uniprotkb:ORP10(gene name synonym)|uniprotkb:OSBP9(gene name synonym) psi-mi:nips2_human(display_long)|uniprotkb:NIPSNAP2(gene name)|psi-mi:NIPSNAP2(display_short)|uniprotkb:GBAS(gene name synonym)|uniprotkb:Glioblastoma-amplified sequence(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514827|imex:IM-12079-94 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000144645(gene)|ensembl:ENST00000396556(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005548"(phospholipid transporter activity)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0015248"(sterol transporter activity)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016020"(membrane)|go:"GO:0032934"(sterol binding)|go:"GO:0036150"(phosphatidylserine acyl-chain remodeling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR000648(Oxysterol-binding protein)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR018494|interpro:IPR037239|interpro:IPR041680|reactome:R-HSA-1482801|refseq:NP_001167531.1|refseq:NP_060254.2 refseq:NP_001189398.1|refseq:NP_001474.1|go:"GO:0006119"(oxidative phosphorylation)|go:"GO:0007005"(mitochondrion organization)|go:"GO:1901843"(positive regulation of high voltage-gated calcium channel activity)|interpro:IPR011008(Dimeric alpha-beta barrel)|interpro:IPR012577(NIPSNAP)|mint:O75323|reactome:R-HSA-9013407|reactome:R-HSA-9013409|ensembl:ENSG00000146729(gene)|ensembl:ENST00000322090(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|dip:DIP-33564N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:1vbWq9QaTg7Nm56KJy7HKUoxWj49606 rogid:sfBQGdtSVoH21kBu/Bz9x8x3KWU9606 intact-crc:E74BDC6212E0F549|rigid:Kjoa5d5JB35C+b9ef0aWj070oGE false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9BXB5 uniprotkb:P08253 intact:EBI-2511286|ensembl:ENSP00000379804|uniprotkb:Q9BTU5|uniprotkb:B4E212 intact:EBI-1033518|uniprotkb:B2R6U1|uniprotkb:Q9UCJ8|ensembl:ENSP00000219070|uniprotkb:E9PE45|uniprotkb:B4DWH3 psi-mi:osb10_human(display_long)|uniprotkb:OSBPL10(gene name)|psi-mi:OSBPL10(display_short)|uniprotkb:ORP10(gene name synonym)|uniprotkb:OSBP9(gene name synonym) psi-mi:mmp2_human(display_long)|uniprotkb:MMP2(gene name)|psi-mi:MMP2(display_short)|uniprotkb:CLG4A(gene name synonym)|uniprotkb:72 kDa gelatinase(gene name synonym)|uniprotkb:Matrix metalloproteinase-2(gene name synonym)|uniprotkb:Gelatinase A(gene name synonym)|uniprotkb:TBE-1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514827|imex:IM-12079-94 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000144645(gene)|ensembl:ENST00000396556(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005548"(phospholipid transporter activity)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0015248"(sterol transporter activity)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016020"(membrane)|go:"GO:0032934"(sterol binding)|go:"GO:0036150"(phosphatidylserine acyl-chain remodeling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR000648(Oxysterol-binding protein)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR018494|interpro:IPR037239|interpro:IPR041680|reactome:R-HSA-1482801|refseq:NP_001167531.1|refseq:NP_060254.2 refseq:NP_001289437.1|refseq:NP_001289438.1|refseq:NP_001289439.1|ensembl:ENSG00000087245(gene)|ensembl:ENST00000219070(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001955"(blood vessel maturation)|go:"GO:0001957"(intramembranous ossification)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005886"(plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0007566"(embryo implantation)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0030017"(sarcomere)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030574"(collagen catabolic process)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0044267"(cellular protein metabolic process)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048771"(tissue remodeling)|go:"GO:0060325"(face morphogenesis)|go:"GO:0060346"(bone trabecula formation)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0071492"(cellular response to UV-A)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|interpro:IPR000562(Type II fibronectin, collagen-binding)|interpro:IPR000585(Hemopexin)|interpro:IPR001818(Peptidase M10A and M12B, matrixin and adamalysin)|interpro:IPR002477(Peptidoglycan binding-like)|interpro:IPR006026(Peptidase, metallopeptidases)|interpro:IPR013806(Kringle-like fold)|interpro:IPR018486|interpro:IPR018487|interpro:IPR021158|interpro:IPR021190|interpro:IPR024079|interpro:IPR028708|interpro:IPR033739|interpro:IPR036365|interpro:IPR036375|interpro:IPR036943|rcsb pdb:1CK7|rcsb pdb:1CXW|rcsb pdb:1EAK|rcsb pdb:1GEN|rcsb pdb:1GXD|rcsb pdb:1HOV|rcsb pdb:1J7M|rcsb pdb:1KS0|rcsb pdb:1QIB|rcsb pdb:1RTG|rcsb pdb:3AYU|reactome:R-HSA-1442490|reactome:R-HSA-1474228|reactome:R-HSA-1592389|reactome:R-HSA-381426|reactome:R-HSA-3928665|reactome:R-HSA-6785807|reactome:R-HSA-9009391|refseq:NP_001121363.1|refseq:NP_004521.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:1vbWq9QaTg7Nm56KJy7HKUoxWj49606 rogid:s0IHoSkzT9GNfkkLZsVsV7cIf1g9606 intact-crc:E74BDC6212E0F549|rigid:Kjoa5d5JB35C+b9ef0aWj070oGE false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q6ZVD8 uniprotkb:P62068 intact:EBI-2511496|uniprotkb:Q9NV17|uniprotkb:Q9Y2E3|uniprotkb:A1L374|ensembl:ENSP00000457991 intact:EBI-2512753|ensembl:ENSP00000407818|uniprotkb:B7Z675|uniprotkb:Q9H7U4|uniprotkb:B7Z7S3|uniprotkb:B7Z3Y7|uniprotkb:Q80V95|uniprotkb:Q9H9T8|uniprotkb:G8ACC7 psi-mi:phlp2_human(display_long)|uniprotkb:PHLPP2(gene name)|psi-mi:PHLPP2(display_short)|uniprotkb:KIAA0931(gene name synonym)|uniprotkb:PHLPPL(gene name synonym)|uniprotkb:PH domain leucine-rich repeat-containing protein phosphatase-like(gene name synonym) psi-mi:ubp46_human(display_long)|uniprotkb:USP46(gene name)|psi-mi:USP46(display_short)|uniprotkb:Ubiquitin-specific-processing protease 46(gene name synonym)|uniprotkb:Deubiquitinating enzyme 46(gene name synonym)|uniprotkb:Ubiquitin thioesterase 46(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514863|imex:IM-12079-44 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001275932.1|refseq:NP_055835.2|dip:DIP-53556N|ensembl:ENSG00000040199(gene)|ensembl:ENST00000568954(transcript)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0021766"(hippocampus development)|go:"GO:0042622"(photoreceptor outer segment membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045171"(intercellular bridge)|go:"GO:0046872"(metal ion binding)|go:"GO:0072686"(mitotic spindle)|go:"GO:0106306"|go:"GO:0106307"|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR001932(Protein phosphatase 2C-related)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR032675|interpro:IPR036457|reactome:R-HSA-199418 ensembl:ENSG00000109189(gene)|ensembl:ENST00000441222(transcript)|go:"GO:0001662"(behavioral fear response)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008343"(adult feeding behavior)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0032228"(regulation of synaptic transmission, GABAergic)|go:"GO:0046872"(metal ion binding)|go:"GO:0048149"(behavioral response to ethanol)|go:"GO:0060013"(righting reflex)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|mint:P62068|rcsb pdb:5CVM|rcsb pdb:5CVN|rcsb pdb:5CVO|rcsb pdb:5L8H|rcsb pdb:6JLQ|refseq:NP_001273696.1|refseq:NP_001273697.1|refseq:NP_001127695.1|refseq:NP_073743.2|dip:DIP-53590N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:Z6e8RRJ8TleJRWTlecN3DNu1Ums9606 rogid:MYmLwHkGXhvq+vVvr88amlicCbg9606 intact-crc:B597E676BD58E8CC|rigid:ZQWTxdCC4avDNP3ANl9Fsmn/dvg false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q6ZVD8 uniprotkb:O94782 intact:EBI-2511496|uniprotkb:Q9NV17|uniprotkb:Q9Y2E3|uniprotkb:A1L374|ensembl:ENSP00000457991 intact:EBI-2513396|ensembl:ENSP00000343526|ensembl:ENSP00000360188|uniprotkb:Q9UNJ3|uniprotkb:A0PJ95|uniprotkb:Q9UFR0|uniprotkb:Q59H66|uniprotkb:Q05BX7|uniprotkb:D3DQ57 psi-mi:phlp2_human(display_long)|uniprotkb:PHLPP2(gene name)|psi-mi:PHLPP2(display_short)|uniprotkb:KIAA0931(gene name synonym)|uniprotkb:PHLPPL(gene name synonym)|uniprotkb:PH domain leucine-rich repeat-containing protein phosphatase-like(gene name synonym) psi-mi:ubp1_human(display_long)|uniprotkb:USP1(gene name)|psi-mi:USP1(display_short)|uniprotkb:Ubiquitin-specific-processing protease 1(gene name synonym)|uniprotkb:Deubiquitinating enzyme 1(gene name synonym)|uniprotkb:Ubiquitin thioesterase 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514863|imex:IM-12079-44 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001275932.1|refseq:NP_055835.2|dip:DIP-53556N|ensembl:ENSG00000040199(gene)|ensembl:ENST00000568954(transcript)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0021766"(hippocampus development)|go:"GO:0042622"(photoreceptor outer segment membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045171"(intercellular bridge)|go:"GO:0046872"(metal ion binding)|go:"GO:0072686"(mitotic spindle)|go:"GO:0106306"|go:"GO:0106307"|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR001932(Protein phosphatase 2C-related)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR032675|interpro:IPR036457|reactome:R-HSA-199418 ensembl:ENSG00000162607(gene)|ensembl:ENST00000339950(transcript)|ensembl:ENST00000371146(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008233"(peptidase activity)|go:"GO:0009411"(response to UV)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035520"(monoubiquitinated protein deubiquitination)|go:"GO:0042769"(obsolete DNA damage response, detection of DNA damage)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR033815|interpro:IPR038765|mint:O94782|rcsb pdb:6DO5|rcsb pdb:7AY0|rcsb pdb:7AY1|rcsb pdb:7AY2|reactome:R-HSA-110314|reactome:R-HSA-6783310|refseq:NP_001017415.1|refseq:NP_001017416.1|refseq:NP_003359.3|dip:DIP-53609N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:Z6e8RRJ8TleJRWTlecN3DNu1Ums9606 rogid:cSWX5JiI+vqbREjhCJeCGAiiVzE9606 intact-crc:B597E676BD58E8CC|rigid:ZQWTxdCC4avDNP3ANl9Fsmn/dvg false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q6ZVD8 uniprotkb:P35241 intact:EBI-2511496|uniprotkb:Q9NV17|uniprotkb:Q9Y2E3|uniprotkb:A1L374|ensembl:ENSP00000457991 intact:EBI-2514878|ensembl:ENSP00000496503|uniprotkb:Q86Y61|uniprotkb:A7YIK0|uniprotkb:A7YIK3|uniprotkb:A7YIJ8|uniprotkb:B7Z9U6|uniprotkb:F5H1A7 psi-mi:phlp2_human(display_long)|uniprotkb:PHLPP2(gene name)|psi-mi:PHLPP2(display_short)|uniprotkb:KIAA0931(gene name synonym)|uniprotkb:PHLPPL(gene name synonym)|uniprotkb:PH domain leucine-rich repeat-containing protein phosphatase-like(gene name synonym) psi-mi:radi_human(display_long)|uniprotkb:RDX(gene name)|psi-mi:RDX(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514863|imex:IM-12079-44 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001275932.1|refseq:NP_055835.2|dip:DIP-53556N|ensembl:ENSG00000040199(gene)|ensembl:ENST00000568954(transcript)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0021766"(hippocampus development)|go:"GO:0042622"(photoreceptor outer segment membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045171"(intercellular bridge)|go:"GO:0046872"(metal ion binding)|go:"GO:0072686"(mitotic spindle)|go:"GO:0106306"|go:"GO:0106307"|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR001932(Protein phosphatase 2C-related)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR032675|interpro:IPR036457|reactome:R-HSA-199418 ensembl:ENSG00000137710(gene)|ensembl:ENST00000645495(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008361"(regulation of cell size)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010737"(protein kinase A signaling)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030027"(lamellipodium)|go:"GO:0030175"(filopodium)|go:"GO:0030315"(T-tubule)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030496"(midbody)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032231"(regulation of actin filament bundle assembly)|go:"GO:0032487"(regulation of Rap protein signal transduction)|go:"GO:0034111"(negative regulation of homotypic cell-cell adhesion)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0045176"(apical protein localization)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045296"(cadherin binding)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0051016"(barbed-end actin filament capping)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051286"(cell tip)|go:"GO:0061028"(establishment of endothelial barrier)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071944"(cell periphery)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097067"(cellular response to thyroid hormone stimulus)|go:"GO:1900027"(regulation of ruffle assembly)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1902115"(regulation of organelle assembly)|go:"GO:1902966"(positive regulation of protein localization to early endosome)|go:"GO:1903364"(positive regulation of cellular protein catabolic process)|go:"GO:2000643"(positive regulation of early endosome to late endosome transport)|go:"GO:1903392"(negative regulation of adherens junction organization)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000798(Ezrin/radixin/moesin ERM)|interpro:IPR008954(Moesin)|interpro:IPR011174(Ezrin/radixin/moesin)|interpro:IPR011259(Ezrin/radixin/moesin, C-terminal)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR018979|interpro:IPR018980|interpro:IPR019747|interpro:IPR019748|interpro:IPR019749|interpro:IPR029071|interpro:IPR035963|interpro:IPR041789|mint:P35241|reactome:R-HSA-437239|reactome:R-HSA-9662360|reactome:R-HSA-9662361|refseq:NP_002897.1|refseq:NP_001247423.1|refseq:NP_001247424.1|refseq:NP_001247425.1|refseq:NP_001247421.1|refseq:NP_001247422.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:Z6e8RRJ8TleJRWTlecN3DNu1Ums9606 rogid:75lzbINdL0deHtiWY7IwioSh5749606 intact-crc:B597E676BD58E8CC|rigid:ZQWTxdCC4avDNP3ANl9Fsmn/dvg false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q6ZVD8 uniprotkb:Q96L92 intact:EBI-2511496|uniprotkb:Q9NV17|uniprotkb:Q9Y2E3|uniprotkb:A1L374|ensembl:ENSP00000457991 intact:EBI-2514865|ensembl:ENSP00000400333|uniprotkb:Q9H3K8|uniprotkb:Q4AEJ5|uniprotkb:Q5VWB0|uniprotkb:Q5VWB2|uniprotkb:Q96D79|uniprotkb:Q5VWB1|uniprotkb:Q32Q36|uniprotkb:Q6IPP6|uniprotkb:Q86UB1 psi-mi:phlp2_human(display_long)|uniprotkb:PHLPP2(gene name)|psi-mi:PHLPP2(display_short)|uniprotkb:KIAA0931(gene name synonym)|uniprotkb:PHLPPL(gene name synonym)|uniprotkb:PH domain leucine-rich repeat-containing protein phosphatase-like(gene name synonym) psi-mi:snx27_human(display_long)|uniprotkb:SNX27(gene name)|psi-mi:SNX27(display_short)|uniprotkb:KIAA0488(gene name synonym)|uniprotkb:My014(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514863|imex:IM-12079-44 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001275932.1|refseq:NP_055835.2|dip:DIP-53556N|ensembl:ENSG00000040199(gene)|ensembl:ENST00000568954(transcript)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0021766"(hippocampus development)|go:"GO:0042622"(photoreceptor outer segment membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045171"(intercellular bridge)|go:"GO:0046872"(metal ion binding)|go:"GO:0072686"(mitotic spindle)|go:"GO:0106306"|go:"GO:0106307"|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR001932(Protein phosphatase 2C-related)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR032675|interpro:IPR036457|reactome:R-HSA-199418 ensembl:ENSG00000143376(gene)|ensembl:ENST00000458013(transcript)|go:"GO:0001770"(establishment of natural killer cell polarity)|go:"GO:0001772"(immunological synapse)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007165"(signal transduction)|refseq:NP_001317652.1|refseq:NP_112180.4|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0016197"(endosomal transport)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032266"(phosphatidylinositol-3-phosphate binding)|go:"GO:0032456"(endocytic recycling)|go:"GO:0035091"(phosphatidylinositol binding)|interpro:IPR000159(Ras-association)|interpro:IPR001683(Phox-like)|interpro:IPR028667|interpro:IPR029071|interpro:IPR036034|interpro:IPR036871|interpro:IPR037827|interpro:IPR037831|interpro:IPR037833|interpro:IPR037835|mint:Q96L92|rcsb pdb:4HAS|rcsb pdb:5ZN9|rcsb pdb:6SAK|interpro:IPR001478(PDZ/DHR/GLGF) psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:Z6e8RRJ8TleJRWTlecN3DNu1Ums9606 rogid:UsAQwtTpOo87fFo6fQJNAZxrFe09606 intact-crc:B597E676BD58E8CC|rigid:ZQWTxdCC4avDNP3ANl9Fsmn/dvg false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q6ZVD8 uniprotkb:O14745 intact:EBI-2511496|uniprotkb:Q9NV17|uniprotkb:Q9Y2E3|uniprotkb:A1L374|ensembl:ENSP00000457991 intact:EBI-349787|uniprotkb:O43552|uniprotkb:Q86WQ5|ensembl:ENSP00000262613|uniprotkb:B3KY21|intact:EBI-15579389 psi-mi:phlp2_human(display_long)|uniprotkb:PHLPP2(gene name)|psi-mi:PHLPP2(display_short)|uniprotkb:KIAA0931(gene name synonym)|uniprotkb:PHLPPL(gene name synonym)|uniprotkb:PH domain leucine-rich repeat-containing protein phosphatase-like(gene name synonym) psi-mi:nhrf1_human(display_long)|uniprotkb:SLC9A3R1(gene name)|psi-mi:SLC9A3R1(display_short)|uniprotkb:NHERF(gene name synonym)|uniprotkb:NHERF1(gene name synonym)|uniprotkb:Ezrin-radixin-moesin-binding phosphoprotein 50(gene name synonym)|uniprotkb:"Regulatory cofactor of Na(+)/H(+) exchanger"(gene name synonym)|uniprotkb:Sodium-hydrogen exchanger regulatory factor 1(gene name synonym)|uniprotkb:Solute carrier family 9 isoform A3 regulatory factor 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514863|imex:IM-12079-44 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001275932.1|refseq:NP_055835.2|dip:DIP-53556N|ensembl:ENSG00000040199(gene)|ensembl:ENST00000568954(transcript)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0021766"(hippocampus development)|go:"GO:0042622"(photoreceptor outer segment membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045171"(intercellular bridge)|go:"GO:0046872"(metal ion binding)|go:"GO:0072686"(mitotic spindle)|go:"GO:0106306"|go:"GO:0106307"|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR001932(Protein phosphatase 2C-related)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR032675|interpro:IPR036457|reactome:R-HSA-199418 refseq:NP_004243.1|ensembl:ENSG00000109062(gene)|ensembl:ENST00000262613(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0002009"(morphogenesis of an epithelium)|go:"GO:0003096"(renal sodium ion transport)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005902"(microvillus)|go:"GO:0007009"(plasma membrane organization)|go:"GO:0007097"(nuclear migration)|go:"GO:0007191"(adenylate cyclase-activating dopamine receptor signaling pathway)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008361"(regulation of cell size)|go:"GO:0010642"(negative regulation of platelet-derived growth factor receptor signaling pathway)|go:"GO:0012505"(endomembrane system)|go:"GO:0014067"(negative regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0015185"(gamma-aminobutyric acid transmembrane transporter activity)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017081"(chloride channel regulator activity)|go:"GO:0019902"(phosphatase binding)|go:"GO:0019933"(cAMP-mediated signaling)|go:"GO:0022612"(gland morphogenesis)|go:"GO:0030033"(microvillus assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030175"(filopodium)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030643"(cellular phosphate ion homeostasis)|go:"GO:0031526"(brush border membrane)|go:"GO:0031528"(microvillus membrane)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0031799"(type 2 metabotropic glutamate receptor binding)|go:"GO:0031800"(type 3 metabotropic glutamate receptor binding)|go:"GO:0031982"(vesicle)|go:"GO:0032415"("regulation of sodium:proton antiporter activity")|go:"GO:0032416"("negative regulation of sodium:proton antiporter activity")|go:"GO:0032426"(stereocilium tip)|go:"GO:0032782"(bile acid secretion)|go:"GO:0034635"(glutathione transport)|go:"GO:0034767"(positive regulation of ion transmembrane transport)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0043621"(protein self-association)|go:"GO:0044062"(regulation of excretion)|go:"GO:0044782"(cilium organization)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045159"(myosin II binding)|go:"GO:0045198"(establishment of epithelial cell apical/basal polarity)|go:"GO:0045199"(maintenance of epithelial cell apical/basal polarity)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050780"(dopamine receptor binding)|go:"GO:0051683"(establishment of Golgi localization)|go:"GO:0051939"(gamma-aminobutyric acid import)|go:"GO:0060088"(auditory receptor cell stereocilium organization)|go:"GO:0060158"(phospholipase C-activating dopamine receptor signaling pathway)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070293"(renal absorption)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070851"(growth factor receptor binding)|go:"GO:0071944"(cell periphery)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090660"(cerebrospinal fluid circulation)|go:"GO:0097225"(sperm midpiece)|go:"GO:0097291"(renal phosphate ion absorption)|go:"GO:0098739"(import across plasma membrane)|go:"GO:0098797"(plasma membrane protein complex)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR015098(EBP50, C-terminal)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|interpro:IPR017300("Na(+)/H(+) exchange regulatory cofactor NHE-RF")|interpro:IPR031199|interpro:IPR036034|interpro:IPR041489|mint:O14745|rcsb pdb:1G9O|rcsb pdb:1GQ4|rcsb pdb:1GQ5|rcsb pdb:1I92|rcsb pdb:1SGH|rcsb pdb:2D10|rcsb pdb:2JXO|rcsb pdb:2KJD|rcsb pdb:2KRG|rcsb pdb:2M0T|rcsb pdb:2M0U|rcsb pdb:2M0V|rcsb pdb:2OZF|rcsb pdb:4JL7|rcsb pdb:4LMM|rcsb pdb:4N6X|rcsb pdb:4PQW|rcsb pdb:4Q3H|rcsb pdb:6RQR|rcsb pdb:4MPA|dip:DIP-29092N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:Z6e8RRJ8TleJRWTlecN3DNu1Ums9606 rogid:03E30U6coFBcC3BeKOYnInfG/BI9606 intact-crc:B597E676BD58E8CC|rigid:ZQWTxdCC4avDNP3ANl9Fsmn/dvg false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q6ZVD8 uniprotkb:Q15599 intact:EBI-2511496|uniprotkb:Q9NV17|uniprotkb:Q9Y2E3|uniprotkb:A1L374|ensembl:ENSP00000457991 intact:EBI-1149760|uniprotkb:O00272|uniprotkb:O00556|uniprotkb:Q3KQY7|uniprotkb:D3DU84|uniprotkb:D3DU85|uniprotkb:H3BSV6|ensembl:ENSP00000408005|intact:EBI-15579694 psi-mi:phlp2_human(display_long)|uniprotkb:PHLPP2(gene name)|psi-mi:PHLPP2(display_short)|uniprotkb:KIAA0931(gene name synonym)|uniprotkb:PHLPPL(gene name synonym)|uniprotkb:PH domain leucine-rich repeat-containing protein phosphatase-like(gene name synonym) psi-mi:nhrf2_human(display_long)|uniprotkb:SLC9A3R2(gene name)|psi-mi:SLC9A3R2(display_short)|uniprotkb:NHERF2(gene name synonym)|uniprotkb:Tyrosine kinase activator protein 1(gene name synonym)|uniprotkb:SRY-interacting protein 1(gene name synonym)|uniprotkb:Solute carrier family 9 isoform A3 regulatory factor 2(gene name synonym)|uniprotkb:NHE3 kinase A regulatory protein E3KARP(gene name synonym)|uniprotkb:Sodium-hydrogen exchanger regulatory factor 2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514863|imex:IM-12079-44 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001275932.1|refseq:NP_055835.2|dip:DIP-53556N|ensembl:ENSG00000040199(gene)|ensembl:ENST00000568954(transcript)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0021766"(hippocampus development)|go:"GO:0042622"(photoreceptor outer segment membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045171"(intercellular bridge)|go:"GO:0046872"(metal ion binding)|go:"GO:0072686"(mitotic spindle)|go:"GO:0106306"|go:"GO:0106307"|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR001932(Protein phosphatase 2C-related)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR032675|interpro:IPR036457|reactome:R-HSA-199418 refseq:NP_001123484.1|refseq:NP_004776.3|refseq:NP_001239002.1|ensembl:ENSG00000065054(gene)|ensembl:ENST00000424542(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0012505"(endomembrane system)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019902"(phosphatase binding)|go:"GO:0031799"(type 2 metabotropic glutamate receptor binding)|go:"GO:0031800"(type 3 metabotropic glutamate receptor binding)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0045296"(cadherin binding)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR015098(EBP50, C-terminal)|interpro:IPR017300("Na(+)/H(+) exchange regulatory cofactor NHE-RF")|interpro:IPR031197|interpro:IPR036034|mint:Q15599|rcsb pdb:2D11|rcsb pdb:2HE4|rcsb pdb:2OCS|rcsb pdb:4P0C|go:"GO:0042802"(identical protein binding)|dip:DIP-29093N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:Z6e8RRJ8TleJRWTlecN3DNu1Ums9606 rogid:BRqFx6BigKEZV84KUdfvppEXg+s9606 intact-crc:B597E676BD58E8CC|rigid:ZQWTxdCC4avDNP3ANl9Fsmn/dvg false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q6ZVD8 uniprotkb:Q8TBZ3 intact:EBI-2511496|uniprotkb:Q9NV17|uniprotkb:Q9Y2E3|uniprotkb:A1L374|ensembl:ENSP00000457991 intact:EBI-2511486|ensembl:ENSP00000341037|uniprotkb:Q8WXX2|uniprotkb:Q9UF86|uniprotkb:Q8NCN7|intact:EBI-11109494|uniprotkb:H0YJJ1|uniprotkb:Q86TU2|uniprotkb:B4DN18|uniprotkb:E7EUY8|uniprotkb:F8W9S4|uniprotkb:G3V2F8|uniprotkb:G3V5R0 psi-mi:phlp2_human(display_long)|uniprotkb:PHLPP2(gene name)|psi-mi:PHLPP2(display_short)|uniprotkb:KIAA0931(gene name synonym)|uniprotkb:PHLPPL(gene name synonym)|uniprotkb:PH domain leucine-rich repeat-containing protein phosphatase-like(gene name synonym) psi-mi:wdr20_human(display_long)|uniprotkb:WDR20(gene name)|psi-mi:WDR20(display_short)|uniprotkb:Protein DMR(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514863|imex:IM-12079-44 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001275932.1|refseq:NP_055835.2|dip:DIP-53556N|ensembl:ENSG00000040199(gene)|ensembl:ENST00000568954(transcript)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0021766"(hippocampus development)|go:"GO:0042622"(photoreceptor outer segment membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045171"(intercellular bridge)|go:"GO:0046872"(metal ion binding)|go:"GO:0072686"(mitotic spindle)|go:"GO:0106306"|go:"GO:0106307"|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR001932(Protein phosphatase 2C-related)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR032675|interpro:IPR036457|reactome:R-HSA-199418 ensembl:ENSG00000140153(gene)|ensembl:ENST00000342702(transcript)|go:"GO:0005654"(nucleoplasm)|interpro:IPR001680(WD40 repeat)|interpro:IPR036322|mint:Q8TBZ3|rcsb pdb:5K19|rcsb pdb:5K1C|rcsb pdb:6JLQ|reactome:R-HSA-5689880|refseq:NP_001229343.1|refseq:NP_001229345.1|refseq:NP_001229346.1|refseq:NP_001229347.1|refseq:NP_653175.2|refseq:NP_851808.1|refseq:NP_851825.1|refseq:NP_001229344.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:Z6e8RRJ8TleJRWTlecN3DNu1Ums9606 rogid:2MfZps9YU8xQbWazkq2sIqXjHHg9606 intact-crc:B597E676BD58E8CC|rigid:ZQWTxdCC4avDNP3ANl9Fsmn/dvg false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q6ZVD8 uniprotkb:O75317 intact:EBI-2511496|uniprotkb:Q9NV17|uniprotkb:Q9Y2E3|uniprotkb:A1L374|ensembl:ENSP00000457991 intact:EBI-2511507|ensembl:ENSP00000282344|uniprotkb:Q8TC49|uniprotkb:Q5VZV3|uniprotkb:A8K0X0 psi-mi:phlp2_human(display_long)|uniprotkb:PHLPP2(gene name)|psi-mi:PHLPP2(display_short)|uniprotkb:KIAA0931(gene name synonym)|uniprotkb:PHLPPL(gene name synonym)|uniprotkb:PH domain leucine-rich repeat-containing protein phosphatase-like(gene name synonym) psi-mi:ubp12_human(display_long)|uniprotkb:USP12(gene name)|psi-mi:USP12(display_short)|uniprotkb:UBH1(gene name synonym)|uniprotkb:USP12L1(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 12(gene name synonym)|uniprotkb:Deubiquitinating enzyme 12(gene name synonym)|uniprotkb:Ubiquitin-hydrolyzing enzyme 1(gene name synonym)|uniprotkb:Ubiquitin thioesterase 12(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514863|imex:IM-12079-44 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001275932.1|refseq:NP_055835.2|dip:DIP-53556N|ensembl:ENSG00000040199(gene)|ensembl:ENST00000568954(transcript)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0021766"(hippocampus development)|go:"GO:0042622"(photoreceptor outer segment membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045171"(intercellular bridge)|go:"GO:0046872"(metal ion binding)|go:"GO:0072686"(mitotic spindle)|go:"GO:0106306"|go:"GO:0106307"|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR001932(Protein phosphatase 2C-related)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR032675|interpro:IPR036457|reactome:R-HSA-199418 ensembl:ENSG00000152484(gene)|ensembl:ENST00000282344(transcript)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0046872"(metal ion binding)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|mint:O75317|rcsb pdb:5K16|rcsb pdb:5K1A|rcsb pdb:5K1B|rcsb pdb:5K1C|rcsb pdb:5L8W|reactome:R-HSA-5689880|refseq:NP_872294.2 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:Z6e8RRJ8TleJRWTlecN3DNu1Ums9606 rogid:SiueMBicjAsFl2OGlBfQ6tg1cf89606 intact-crc:B597E676BD58E8CC|rigid:ZQWTxdCC4avDNP3ANl9Fsmn/dvg false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q6ZVD8 uniprotkb:Q99536 intact:EBI-2511496|uniprotkb:Q9NV17|uniprotkb:Q9Y2E3|uniprotkb:A1L374|ensembl:ENSP00000457991 intact:EBI-2514883|ensembl:ENSP00000347872|uniprotkb:Q5BKZ7|uniprotkb:A8K345|uniprotkb:Q13035|uniprotkb:Q9BUT8|uniprotkb:Q96A39|uniprotkb:B0AZP7|uniprotkb:B4DPX4 psi-mi:phlp2_human(display_long)|uniprotkb:PHLPP2(gene name)|psi-mi:PHLPP2(display_short)|uniprotkb:KIAA0931(gene name synonym)|uniprotkb:PHLPPL(gene name synonym)|uniprotkb:PH domain leucine-rich repeat-containing protein phosphatase-like(gene name synonym) psi-mi:vat1_human(display_long)|uniprotkb:VAT1(gene name)|psi-mi:VAT1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514863|imex:IM-12079-44 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001275932.1|refseq:NP_055835.2|dip:DIP-53556N|ensembl:ENSG00000040199(gene)|ensembl:ENST00000568954(transcript)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0021766"(hippocampus development)|go:"GO:0042622"(photoreceptor outer segment membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045171"(intercellular bridge)|go:"GO:0046872"(metal ion binding)|go:"GO:0072686"(mitotic spindle)|go:"GO:0106306"|go:"GO:0106307"|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR001932(Protein phosphatase 2C-related)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR032675|interpro:IPR036457|reactome:R-HSA-199418 rcsb pdb:6K9Y|rcsb pdb:6LHR|rcsb pdb:6LII|reactome:R-HSA-6798695|ensembl:ENSG00000108828(gene)|ensembl:ENST00000355653(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002364(Quinone oxidoreductase/zeta-crystallin, conserved site)|interpro:IPR011032(GroES-like)|interpro:IPR013154(Alcohol dehydrogenase GroES-like)|interpro:IPR020843|interpro:IPR036291|mint:Q99536|refseq:NP_006364.2 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:Z6e8RRJ8TleJRWTlecN3DNu1Ums9606 rogid:CaICWyJ+h3ry4itndQodektQFQo9606 intact-crc:B597E676BD58E8CC|rigid:ZQWTxdCC4avDNP3ANl9Fsmn/dvg false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q6ZVD8 uniprotkb:P15311 intact:EBI-2511496|uniprotkb:Q9NV17|uniprotkb:Q9Y2E3|uniprotkb:A1L374|ensembl:ENSP00000457991 intact:EBI-1056902|uniprotkb:P23714|uniprotkb:Q4VX75|uniprotkb:Q96CU8|uniprotkb:Q9NSJ4|uniprotkb:E1P5A8|ensembl:ENSP00000338934|ensembl:ENSP00000356042 psi-mi:phlp2_human(display_long)|uniprotkb:PHLPP2(gene name)|psi-mi:PHLPP2(display_short)|uniprotkb:KIAA0931(gene name synonym)|uniprotkb:PHLPPL(gene name synonym)|uniprotkb:PH domain leucine-rich repeat-containing protein phosphatase-like(gene name synonym) psi-mi:ezri_human(display_long)|uniprotkb:EZR(gene name)|psi-mi:EZR(display_short)|uniprotkb:VIL2(gene name synonym)|uniprotkb:p81(gene name synonym)|uniprotkb:Cytovillin(gene name synonym)|uniprotkb:Villin-2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514863|imex:IM-12079-44 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001275932.1|refseq:NP_055835.2|dip:DIP-53556N|ensembl:ENSG00000040199(gene)|ensembl:ENST00000568954(transcript)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0021766"(hippocampus development)|go:"GO:0042622"(photoreceptor outer segment membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045171"(intercellular bridge)|go:"GO:0046872"(metal ion binding)|go:"GO:0072686"(mitotic spindle)|go:"GO:0106306"|go:"GO:0106307"|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR001932(Protein phosphatase 2C-related)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR032675|interpro:IPR036457|reactome:R-HSA-199418 ensembl:ENSP00000338934|ensembl:ENSP00000356042|refseq:NP_001104547.1|refseq:NP_003370.2|ensembl:ENSG00000092820(gene)|ensembl:ENST00000337147(transcript)|ensembl:ENST00000367075(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001650"(fibrillar center)|go:"GO:0001726"(ruffle)|go:"GO:0001772"(immunological synapse)|go:"GO:0001931"(uropod)|go:"GO:0001951"(intestinal D-glucose absorption)|go:"GO:0003376"(sphingosine-1-phosphate receptor signaling pathway)|go:"GO:0003723"(RNA binding)|go:"GO:0003779"(actin binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0005903"(brush border)|go:"GO:0005925"(focal adhesion)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0008017"(microtubule binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010737"(protein kinase A signaling)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030033"(microvillus assembly)|go:"GO:0030175"(filopodium)|go:"GO:0030315"(T-tubule)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0031528"(microvillus membrane)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031623"(receptor internalization)|go:"GO:0031982"(vesicle)|go:"GO:0032532"(regulation of microvillus length)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0034629"|go:"GO:0035088"(establishment or maintenance of apical/basal cell polarity)|go:"GO:0036064"(ciliary basal body)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042995"(cell projection)|go:"GO:0043622"(cortical microtubule organization)|go:"GO:0044297"(cell body)|go:"GO:0044393"(microspike)|go:"GO:0044548"(S100 protein binding)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045177"(apical part of cell)|go:"GO:0045296"(cadherin binding)|go:"GO:0046847"(filopodium assembly)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0051015"(actin filament binding)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051286"(cell tip)|go:"GO:0051660"(establishment of centrosome localization)|go:"GO:0061028"(establishment of endothelial barrier)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071944"(cell periphery)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0072697"(protein localization to cell cortex)|go:"GO:0097449"(astrocyte projection)|go:"GO:0097454"(Schwann cell microvillus)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098592"(cytoplasmic side of apical plasma membrane)|go:"GO:1902115"(regulation of organelle assembly)|go:"GO:1902896"(terminal web assembly)|go:"GO:1902966"(positive regulation of protein localization to early endosome)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903364"(positive regulation of cellular protein catabolic process)|go:"GO:1903753"(negative regulation of p38MAPK cascade)|go:"GO:2000643"(positive regulation of early endosome to late endosome transport)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000798(Ezrin/radixin/moesin ERM)|interpro:IPR008954(Moesin)|interpro:IPR011174(Ezrin/radixin/moesin)|interpro:IPR011259(Ezrin/radixin/moesin, C-terminal)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR018979|interpro:IPR018980|interpro:IPR019747|interpro:IPR019748|interpro:IPR019749|interpro:IPR029071|interpro:IPR035963|interpro:IPR041789|mint:P15311|rcsb pdb:1NI2|rcsb pdb:4RM8|rcsb pdb:4RM9|rcsb pdb:4RMA|reactome:R-HSA-373752|reactome:R-HSA-437239|reactome:R-HSA-9662360|reactome:R-HSA-9662361|dip:DIP-38868N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:Z6e8RRJ8TleJRWTlecN3DNu1Ums9606 rogid:tSSki5dutR2qqs2dyN3TqcHyiyM9606 intact-crc:B597E676BD58E8CC|rigid:ZQWTxdCC4avDNP3ANl9Fsmn/dvg false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q6ZVD8 uniprotkb:Q8TAF3 intact:EBI-2511496|uniprotkb:Q9NV17|uniprotkb:Q9Y2E3|uniprotkb:A1L374|ensembl:ENSP00000457991 intact:EBI-1045469|uniprotkb:Q63HJ2|uniprotkb:Q658Y1|uniprotkb:Q8N3Z1|uniprotkb:Q9NSK8|uniprotkb:Q9P279|uniprotkb:B4DM86|uniprotkb:B4DQI2|uniprotkb:B4DY84|ensembl:ENSP00000307491 psi-mi:phlp2_human(display_long)|uniprotkb:PHLPP2(gene name)|psi-mi:PHLPP2(display_short)|uniprotkb:KIAA0931(gene name synonym)|uniprotkb:PHLPPL(gene name synonym)|uniprotkb:PH domain leucine-rich repeat-containing protein phosphatase-like(gene name synonym) psi-mi:wdr48_human(display_long)|uniprotkb:WD repeat endosomal protein(gene name synonym)|uniprotkb:p80(gene name synonym)|uniprotkb:WDR48(gene name)|psi-mi:WDR48(display_short)|uniprotkb:KIAA1449(gene name synonym)|uniprotkb:UAF1(gene name synonym)|uniprotkb:USP1-associated factor 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514863|imex:IM-12079-44 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001275932.1|refseq:NP_055835.2|dip:DIP-53556N|ensembl:ENSG00000040199(gene)|ensembl:ENST00000568954(transcript)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0021766"(hippocampus development)|go:"GO:0042622"(photoreceptor outer segment membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045171"(intercellular bridge)|go:"GO:0046872"(metal ion binding)|go:"GO:0072686"(mitotic spindle)|go:"GO:0106306"|go:"GO:0106307"|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR001932(Protein phosphatase 2C-related)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR032675|interpro:IPR036457|reactome:R-HSA-199418 refseq:NP_065890.1|ensembl:ENSG00000114742(gene)|ensembl:ENST00000302313(transcript)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0003677"(DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043588"(skin development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0072520"(seminiferous tubule development)|go:"GO:1902525"(regulation of protein monoubiquitination)|go:"GO:1903003"(positive regulation of protein deubiquitination)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR021772|interpro:IPR036322|mint:Q8TAF3|rcsb pdb:5CVL|rcsb pdb:5CVN|rcsb pdb:5CVO|rcsb pdb:5K1A|rcsb pdb:5K1B|rcsb pdb:5K1C|rcsb pdb:5L8E|rcsb pdb:5L8W|rcsb pdb:6JLQ|rcsb pdb:7AY0|rcsb pdb:7AY1|rcsb pdb:7AY2|reactome:R-HSA-110314|reactome:R-HSA-5689880|reactome:R-HSA-6783310|reactome:R-HSA-9673766|refseq:NP_001290331.1|refseq:NP_001290332.1|refseq:NP_001333156.1|refseq:NP_001333157.1|dip:DIP-50841N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:Z6e8RRJ8TleJRWTlecN3DNu1Ums9606 rogid:S8ihl3jxEEyMS46AM2ynXSFfCU49606 intact-crc:B597E676BD58E8CC|rigid:ZQWTxdCC4avDNP3ANl9Fsmn/dvg false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O60346 uniprotkb:Q13451 intact:EBI-2511516|intact:EBI-28974360|ensembl:ENSP00000262719|uniprotkb:Q6PJI6|uniprotkb:Q6P4C4|uniprotkb:A1A4F5|uniprotkb:Q641Q7|uniprotkb:Q86TN6|uniprotkb:Q96FK2|uniprotkb:Q9NUY1 intact:EBI-306914|ensembl:ENSP00000349811|ensembl:ENSP00000441205|ensembl:ENSP00000444810|uniprotkb:Q5TGM6|uniprotkb:F5H7R1|uniprotkb:Q59EB8 psi-mi:phlp1_human(display_long)|uniprotkb:PHLPP1(gene name)|psi-mi:PHLPP1(display_short)|uniprotkb:KIAA0606(gene name synonym)|uniprotkb:PHLPP(gene name synonym)|uniprotkb:PLEKHE1(gene name synonym)|uniprotkb:SCOP(gene name synonym)|uniprotkb:Pleckstrin homology domain-containing family E member 1(gene name synonym)|uniprotkb:Suprachiasmatic nucleus circadian oscillatory protein(gene name synonym) psi-mi:fkbp5_human(display_long)|uniprotkb:FKBP5(gene name)|psi-mi:FKBP5(display_short)|uniprotkb:AIG6(gene name synonym)|uniprotkb:FKBP51(gene name synonym)|uniprotkb:FK506-binding protein 5(gene name synonym)|uniprotkb:51 kDa FK506-binding protein(gene name synonym)|uniprotkb:Rotamase(gene name synonym)|uniprotkb:54 kDa progesterone receptor-associated immunophilin(gene name synonym)|uniprotkb:FKBP54(gene name synonym)|uniprotkb:FF1 antigen(gene name synonym)|uniprotkb:HSP90-binding immunophilin(gene name synonym)|uniprotkb:Androgen-regulated protein 6(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514920|imex:IM-12079-95 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000262719|go:"GO:0009649"(entrainment of circadian clock)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046872"(metal ion binding)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1900744"(regulation of p38MAPK cascade)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001932(Protein phosphatase 2C-related)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR032675|interpro:IPR036457|mint:O60346|reactome:R-HSA-199418|ensembl:ENSG00000081913(gene)|ensembl:ENST00000262719(transcript)|go:"GO:0002667"(regulation of T cell anergy)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|refseq:NP_919431.2 ensembl:ENSG00000096060(gene)|ensembl:ENST00000357266(transcript)|ensembl:ENST00000536438(transcript)|ensembl:ENST00000539068(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005528"(FK506 binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0009617"(response to bacterium)|go:"GO:0016020"(membrane)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|refseq:NP_001139247.1|refseq:NP_001139248.1|refseq:NP_004108.1|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR031210|mint:Q13451|rcsb pdb:1KT0|rcsb pdb:3O5D|rcsb pdb:3O5E|rcsb pdb:3O5F|rcsb pdb:3O5G|rcsb pdb:3O5I|rcsb pdb:3O5J|rcsb pdb:3O5K|rcsb pdb:3O5L|rcsb pdb:3O5M|rcsb pdb:3O5O|rcsb pdb:3O5P|rcsb pdb:3O5Q|rcsb pdb:3O5R|rcsb pdb:4DRH|rcsb pdb:4DRI|rcsb pdb:4DRK|rcsb pdb:4DRM|rcsb pdb:4DRN|rcsb pdb:4DRO|rcsb pdb:4DRP|rcsb pdb:4DRQ|rcsb pdb:4JFI|rcsb pdb:4JFJ|rcsb pdb:4JFK|rcsb pdb:4JFL|rcsb pdb:4JFM|rcsb pdb:4R0X|rcsb pdb:4TW6|rcsb pdb:4TW7|rcsb pdb:4TX0|rcsb pdb:4W9O|rcsb pdb:4W9P|rcsb pdb:4W9Q|rcsb pdb:5BXJ|rcsb pdb:5DIT|rcsb pdb:5DIU|rcsb pdb:5DIV|rcsb pdb:5NJX|rcsb pdb:5OBK|rcsb pdb:5OMP|rcsb pdb:6SAF|rcsb pdb:6TX4|rcsb pdb:6TX5|rcsb pdb:6TX6|rcsb pdb:6TX7|rcsb pdb:6TX8|rcsb pdb:6TX9|rcsb pdb:6TXX|rcsb pdb:7A6W|rcsb pdb:7A6X|rcsb pdb:7AOT|rcsb pdb:7AOU|rcsb pdb:7AWF|rcsb pdb:7AWX|rcsb pdb:7B9Y|rcsb pdb:7B9Z|rcsb pdb:7BA0|reactome:R-HSA-3371497|reactome:R-HSA-8939211|reactome:R-HSA-9022699|refseq:NP_001139249.1|dip:DIP-27597N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:hPGjeSVMlJhO3o9YBWoBm9xppfk9606 rogid:m2Bnn01E13sovh3BwG71Pgqjdx89606 intact-crc:2F9EF2D79BA0266C|rigid:s7RZr1AXICwqDpHxFUNW0lKe3BA false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O60346 uniprotkb:Q6ZVD8 intact:EBI-2511516|intact:EBI-28974360|ensembl:ENSP00000262719|uniprotkb:Q6PJI6|uniprotkb:Q6P4C4|uniprotkb:A1A4F5|uniprotkb:Q641Q7|uniprotkb:Q86TN6|uniprotkb:Q96FK2|uniprotkb:Q9NUY1 intact:EBI-2511496|uniprotkb:Q9NV17|uniprotkb:Q9Y2E3|uniprotkb:A1L374|ensembl:ENSP00000457991 psi-mi:phlp1_human(display_long)|uniprotkb:PHLPP1(gene name)|psi-mi:PHLPP1(display_short)|uniprotkb:KIAA0606(gene name synonym)|uniprotkb:PHLPP(gene name synonym)|uniprotkb:PLEKHE1(gene name synonym)|uniprotkb:SCOP(gene name synonym)|uniprotkb:Pleckstrin homology domain-containing family E member 1(gene name synonym)|uniprotkb:Suprachiasmatic nucleus circadian oscillatory protein(gene name synonym) psi-mi:phlp2_human(display_long)|uniprotkb:PHLPP2(gene name)|psi-mi:PHLPP2(display_short)|uniprotkb:KIAA0931(gene name synonym)|uniprotkb:PHLPPL(gene name synonym)|uniprotkb:PH domain leucine-rich repeat-containing protein phosphatase-like(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514920|imex:IM-12079-95 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000262719|go:"GO:0009649"(entrainment of circadian clock)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046872"(metal ion binding)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1900744"(regulation of p38MAPK cascade)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001932(Protein phosphatase 2C-related)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR032675|interpro:IPR036457|mint:O60346|reactome:R-HSA-199418|ensembl:ENSG00000081913(gene)|ensembl:ENST00000262719(transcript)|go:"GO:0002667"(regulation of T cell anergy)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|refseq:NP_919431.2 refseq:NP_001275932.1|refseq:NP_055835.2|dip:DIP-53556N|ensembl:ENSG00000040199(gene)|ensembl:ENST00000568954(transcript)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0021766"(hippocampus development)|go:"GO:0042622"(photoreceptor outer segment membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045171"(intercellular bridge)|go:"GO:0046872"(metal ion binding)|go:"GO:0072686"(mitotic spindle)|go:"GO:0106306"|go:"GO:0106307"|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR001932(Protein phosphatase 2C-related)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR032675|interpro:IPR036457|reactome:R-HSA-199418 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:hPGjeSVMlJhO3o9YBWoBm9xppfk9606 rogid:Z6e8RRJ8TleJRWTlecN3DNu1Ums9606 intact-crc:2F9EF2D79BA0266C|rigid:s7RZr1AXICwqDpHxFUNW0lKe3BA false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O60346 uniprotkb:Q96T37 intact:EBI-2511516|intact:EBI-28974360|ensembl:ENSP00000262719|uniprotkb:Q6PJI6|uniprotkb:Q6P4C4|uniprotkb:A1A4F5|uniprotkb:Q641Q7|uniprotkb:Q86TN6|uniprotkb:Q96FK2|uniprotkb:Q9NUY1 intact:EBI-2514922|ensembl:ENSP00000358799|ensembl:ENSP00000483133|uniprotkb:Q96SC9|uniprotkb:Q5D058|uniprotkb:Q96SD0|uniprotkb:Q5T613|uniprotkb:Q96SC5|uniprotkb:Q96T38|uniprotkb:Q9BRA5|uniprotkb:Q96SC6|uniprotkb:Q9H9Y0|uniprotkb:Q96PE4|uniprotkb:Q9H6R8|uniprotkb:Q4V760|uniprotkb:A1A693|uniprotkb:Q3ZB86|uniprotkb:Q86VW9 psi-mi:phlp1_human(display_long)|uniprotkb:PHLPP1(gene name)|psi-mi:PHLPP1(display_short)|uniprotkb:KIAA0606(gene name synonym)|uniprotkb:PHLPP(gene name synonym)|uniprotkb:PLEKHE1(gene name synonym)|uniprotkb:SCOP(gene name synonym)|uniprotkb:Pleckstrin homology domain-containing family E member 1(gene name synonym)|uniprotkb:Suprachiasmatic nucleus circadian oscillatory protein(gene name synonym) psi-mi:rbm15_human(display_long)|uniprotkb:RBM15(gene name)|psi-mi:RBM15(display_short)|uniprotkb:OTT(gene name synonym)|uniprotkb:OTT1(gene name synonym)|uniprotkb:RNA-binding motif protein 15(gene name synonym)|uniprotkb:One-twenty two protein 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514920|imex:IM-12079-95 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000262719|go:"GO:0009649"(entrainment of circadian clock)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046872"(metal ion binding)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1900744"(regulation of p38MAPK cascade)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001932(Protein phosphatase 2C-related)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR032675|interpro:IPR036457|mint:O60346|reactome:R-HSA-199418|ensembl:ENSG00000081913(gene)|ensembl:ENST00000262719(transcript)|go:"GO:0002667"(regulation of T cell anergy)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|refseq:NP_919431.2 ensembl:ENSG00000162775(gene)|ensembl:ENST00000369784(transcript)|ensembl:ENST00000618772(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0001510"(RNA methylation)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0007221"(positive regulation of transcription of Notch receptor target)|go:"GO:0009048"(dosage compensation by inactivation of X chromosome)|go:"GO:0016607"(nuclear speck)|go:"GO:0031965"(nuclear membrane)|go:"GO:0036396"(RNA N6-methyladenosine methyltransferase complex)|go:"GO:0038163"(thrombopoietin-mediated signaling pathway)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0045652"(regulation of megakaryocyte differentiation)|go:"GO:0048536"(spleen development)|go:"GO:0060674"(placenta blood vessel development)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR010912(Spen paralogue and orthologue C-terminal, metazoa)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR012921(Spen paralogue and orthologue C-terminal)|interpro:IPR016194(Spen Paralogue and Orthologue C-terminal-like)|interpro:IPR034470|interpro:IPR034472|interpro:IPR034473|interpro:IPR035979|mint:Q96T37|go:"GO:0060412"(ventricular septum morphogenesis)|refseq:NP_001188474.1|refseq:NP_073605.4|ensembl:ENSP00000358799|ensembl:ENST00000487146|ensembl:ENSP00000473552|ensembl:ENST00000602849|ensembl:ENSP00000473638|ensembl:ENSP00000483133|ensembl:ENST00000652342|ensembl:ENSP00000498328|ensembl:ENST00000652747|ensembl:ENSP00000498634 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:hPGjeSVMlJhO3o9YBWoBm9xppfk9606 rogid:t7EkMQbmDxPl/X8yPkBi1zCywac9606 intact-crc:2F9EF2D79BA0266C|rigid:s7RZr1AXICwqDpHxFUNW0lKe3BA false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O60346 uniprotkb:Q96L92 intact:EBI-2511516|intact:EBI-28974360|ensembl:ENSP00000262719|uniprotkb:Q6PJI6|uniprotkb:Q6P4C4|uniprotkb:A1A4F5|uniprotkb:Q641Q7|uniprotkb:Q86TN6|uniprotkb:Q96FK2|uniprotkb:Q9NUY1 intact:EBI-2514865|ensembl:ENSP00000400333|uniprotkb:Q9H3K8|uniprotkb:Q4AEJ5|uniprotkb:Q5VWB0|uniprotkb:Q5VWB2|uniprotkb:Q96D79|uniprotkb:Q5VWB1|uniprotkb:Q32Q36|uniprotkb:Q6IPP6|uniprotkb:Q86UB1 psi-mi:phlp1_human(display_long)|uniprotkb:PHLPP1(gene name)|psi-mi:PHLPP1(display_short)|uniprotkb:KIAA0606(gene name synonym)|uniprotkb:PHLPP(gene name synonym)|uniprotkb:PLEKHE1(gene name synonym)|uniprotkb:SCOP(gene name synonym)|uniprotkb:Pleckstrin homology domain-containing family E member 1(gene name synonym)|uniprotkb:Suprachiasmatic nucleus circadian oscillatory protein(gene name synonym) psi-mi:snx27_human(display_long)|uniprotkb:SNX27(gene name)|psi-mi:SNX27(display_short)|uniprotkb:KIAA0488(gene name synonym)|uniprotkb:My014(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514920|imex:IM-12079-95 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000262719|go:"GO:0009649"(entrainment of circadian clock)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046872"(metal ion binding)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1900744"(regulation of p38MAPK cascade)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001932(Protein phosphatase 2C-related)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR032675|interpro:IPR036457|mint:O60346|reactome:R-HSA-199418|ensembl:ENSG00000081913(gene)|ensembl:ENST00000262719(transcript)|go:"GO:0002667"(regulation of T cell anergy)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|refseq:NP_919431.2 ensembl:ENSG00000143376(gene)|ensembl:ENST00000458013(transcript)|go:"GO:0001770"(establishment of natural killer cell polarity)|go:"GO:0001772"(immunological synapse)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007165"(signal transduction)|refseq:NP_001317652.1|refseq:NP_112180.4|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0016197"(endosomal transport)|go:"GO:0031901"(early endosome membrane)|go:"GO:0032266"(phosphatidylinositol-3-phosphate binding)|go:"GO:0032456"(endocytic recycling)|go:"GO:0035091"(phosphatidylinositol binding)|interpro:IPR000159(Ras-association)|interpro:IPR001683(Phox-like)|interpro:IPR028667|interpro:IPR029071|interpro:IPR036034|interpro:IPR036871|interpro:IPR037827|interpro:IPR037831|interpro:IPR037833|interpro:IPR037835|mint:Q96L92|rcsb pdb:4HAS|rcsb pdb:5ZN9|rcsb pdb:6SAK|interpro:IPR001478(PDZ/DHR/GLGF) psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:hPGjeSVMlJhO3o9YBWoBm9xppfk9606 rogid:UsAQwtTpOo87fFo6fQJNAZxrFe09606 intact-crc:2F9EF2D79BA0266C|rigid:s7RZr1AXICwqDpHxFUNW0lKe3BA false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O60346 uniprotkb:Q9P1S2 intact:EBI-2511516|intact:EBI-28974360|ensembl:ENSP00000262719|uniprotkb:Q6PJI6|uniprotkb:Q6P4C4|uniprotkb:A1A4F5|uniprotkb:Q641Q7|uniprotkb:Q86TN6|uniprotkb:Q96FK2|uniprotkb:Q9NUY1 intact:EBI-2511504 psi-mi:phlp1_human(display_long)|uniprotkb:PHLPP1(gene name)|psi-mi:PHLPP1(display_short)|uniprotkb:KIAA0606(gene name synonym)|uniprotkb:PHLPP(gene name synonym)|uniprotkb:PLEKHE1(gene name synonym)|uniprotkb:SCOP(gene name synonym)|uniprotkb:Pleckstrin homology domain-containing family E member 1(gene name synonym)|uniprotkb:Suprachiasmatic nucleus circadian oscillatory protein(gene name synonym) psi-mi:q9p1s2_human(display_long) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514920|imex:IM-12079-95 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000262719|go:"GO:0009649"(entrainment of circadian clock)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046872"(metal ion binding)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1900744"(regulation of p38MAPK cascade)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001932(Protein phosphatase 2C-related)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR032675|interpro:IPR036457|mint:O60346|reactome:R-HSA-199418|ensembl:ENSG00000081913(gene)|ensembl:ENST00000262719(transcript)|go:"GO:0002667"(regulation of T cell anergy)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|refseq:NP_919431.2 go:"GO:0051087"(chaperone binding)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR044563 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:hPGjeSVMlJhO3o9YBWoBm9xppfk9606 rogid:+pC1prCcP9i/pilHXx1M2iZRojs9606 intact-crc:2F9EF2D79BA0266C|rigid:s7RZr1AXICwqDpHxFUNW0lKe3BA false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O60346 uniprotkb:P53041 intact:EBI-2511516|intact:EBI-28974360|ensembl:ENSP00000262719|uniprotkb:Q6PJI6|uniprotkb:Q6P4C4|uniprotkb:A1A4F5|uniprotkb:Q641Q7|uniprotkb:Q86TN6|uniprotkb:Q96FK2|uniprotkb:Q9NUY1 intact:EBI-716663|uniprotkb:Q53XV2|uniprotkb:Q16722|ensembl:ENSP00000012443 psi-mi:phlp1_human(display_long)|uniprotkb:PHLPP1(gene name)|psi-mi:PHLPP1(display_short)|uniprotkb:KIAA0606(gene name synonym)|uniprotkb:PHLPP(gene name synonym)|uniprotkb:PLEKHE1(gene name synonym)|uniprotkb:SCOP(gene name synonym)|uniprotkb:Pleckstrin homology domain-containing family E member 1(gene name synonym)|uniprotkb:Suprachiasmatic nucleus circadian oscillatory protein(gene name synonym) psi-mi:ppp5_human(display_long)|uniprotkb:Protein phosphatase T(gene name synonym)|uniprotkb:PPP5C(gene name)|psi-mi:PPP5C(display_short)|uniprotkb:PPP5(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514920|imex:IM-12079-95 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000262719|go:"GO:0009649"(entrainment of circadian clock)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046872"(metal ion binding)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1900744"(regulation of p38MAPK cascade)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001932(Protein phosphatase 2C-related)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR032675|interpro:IPR036457|mint:O60346|reactome:R-HSA-199418|ensembl:ENSG00000081913(gene)|ensembl:ENST00000262719(transcript)|go:"GO:0002667"(regulation of T cell anergy)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|refseq:NP_919431.2 refseq:NP_006238.1|ensembl:ENSG00000011485(gene)|ensembl:ENST00000012443(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001965"(G-protein alpha-subunit binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0008017"(microtubule binding)|go:"GO:0008289"(lipid binding)|go:"GO:0010288"(response to lead ion)|go:"GO:0016576"(histone dephosphorylation)|go:"GO:0016791"(phosphatase activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035970"(peptidyl-threonine dephosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043204"(perikaryon)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043278"(response to morphine)|go:"GO:0043531"(ADP binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0101031"(chaperone complex)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1904550"(response to arachidonic acid)|go:"GO:1990635"(proximal dendrite)|go:"GO:2000324"(positive regulation of glucocorticoid receptor signaling pathway)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR006186("Serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase")|interpro:IPR011236(Protein phosphatase 5)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013235(Serine/threonine phosphatase, PPP5)|interpro:IPR019734|interpro:IPR029052|interpro:IPR041753|mint:P53041|rcsb pdb:1A17|rcsb pdb:1S95|rcsb pdb:1WAO|rcsb pdb:2BUG|rcsb pdb:3H60|rcsb pdb:3H61|rcsb pdb:3H62|rcsb pdb:3H63|rcsb pdb:3H64|rcsb pdb:3H66|rcsb pdb:3H67|rcsb pdb:3H68|rcsb pdb:3H69|rcsb pdb:4ZVZ|rcsb pdb:4ZX2|rcsb pdb:5HPE|rcsb pdb:5UI1|rcsb pdb:5WG8|reactome:R-HSA-5675221|reactome:R-HSA-5693565|reactome:R-HSA-8939211|dip:DIP-29043N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:hPGjeSVMlJhO3o9YBWoBm9xppfk9606 rogid:5QoNB467ftOvWaUNfSm6RalR8+Y9606 intact-crc:2F9EF2D79BA0266C|rigid:s7RZr1AXICwqDpHxFUNW0lKe3BA false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O60346 uniprotkb:Q8TAF3 intact:EBI-2511516|intact:EBI-28974360|ensembl:ENSP00000262719|uniprotkb:Q6PJI6|uniprotkb:Q6P4C4|uniprotkb:A1A4F5|uniprotkb:Q641Q7|uniprotkb:Q86TN6|uniprotkb:Q96FK2|uniprotkb:Q9NUY1 intact:EBI-1045469|uniprotkb:Q63HJ2|uniprotkb:Q658Y1|uniprotkb:Q8N3Z1|uniprotkb:Q9NSK8|uniprotkb:Q9P279|uniprotkb:B4DM86|uniprotkb:B4DQI2|uniprotkb:B4DY84|ensembl:ENSP00000307491 psi-mi:phlp1_human(display_long)|uniprotkb:PHLPP1(gene name)|psi-mi:PHLPP1(display_short)|uniprotkb:KIAA0606(gene name synonym)|uniprotkb:PHLPP(gene name synonym)|uniprotkb:PLEKHE1(gene name synonym)|uniprotkb:SCOP(gene name synonym)|uniprotkb:Pleckstrin homology domain-containing family E member 1(gene name synonym)|uniprotkb:Suprachiasmatic nucleus circadian oscillatory protein(gene name synonym) psi-mi:wdr48_human(display_long)|uniprotkb:WD repeat endosomal protein(gene name synonym)|uniprotkb:p80(gene name synonym)|uniprotkb:WDR48(gene name)|psi-mi:WDR48(display_short)|uniprotkb:KIAA1449(gene name synonym)|uniprotkb:UAF1(gene name synonym)|uniprotkb:USP1-associated factor 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514920|imex:IM-12079-95 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000262719|go:"GO:0009649"(entrainment of circadian clock)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046872"(metal ion binding)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1900744"(regulation of p38MAPK cascade)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001932(Protein phosphatase 2C-related)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR032675|interpro:IPR036457|mint:O60346|reactome:R-HSA-199418|ensembl:ENSG00000081913(gene)|ensembl:ENST00000262719(transcript)|go:"GO:0002667"(regulation of T cell anergy)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|refseq:NP_919431.2 refseq:NP_065890.1|ensembl:ENSG00000114742(gene)|ensembl:ENST00000302313(transcript)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0003677"(DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043588"(skin development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0072520"(seminiferous tubule development)|go:"GO:1902525"(regulation of protein monoubiquitination)|go:"GO:1903003"(positive regulation of protein deubiquitination)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR021772|interpro:IPR036322|mint:Q8TAF3|rcsb pdb:5CVL|rcsb pdb:5CVN|rcsb pdb:5CVO|rcsb pdb:5K1A|rcsb pdb:5K1B|rcsb pdb:5K1C|rcsb pdb:5L8E|rcsb pdb:5L8W|rcsb pdb:6JLQ|rcsb pdb:7AY0|rcsb pdb:7AY1|rcsb pdb:7AY2|reactome:R-HSA-110314|reactome:R-HSA-5689880|reactome:R-HSA-6783310|reactome:R-HSA-9673766|refseq:NP_001290331.1|refseq:NP_001290332.1|refseq:NP_001333156.1|refseq:NP_001333157.1|dip:DIP-50841N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:hPGjeSVMlJhO3o9YBWoBm9xppfk9606 rogid:S8ihl3jxEEyMS46AM2ynXSFfCU49606 intact-crc:2F9EF2D79BA0266C|rigid:s7RZr1AXICwqDpHxFUNW0lKe3BA false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O60346 uniprotkb:Q8TBZ3 intact:EBI-2511516|intact:EBI-28974360|ensembl:ENSP00000262719|uniprotkb:Q6PJI6|uniprotkb:Q6P4C4|uniprotkb:A1A4F5|uniprotkb:Q641Q7|uniprotkb:Q86TN6|uniprotkb:Q96FK2|uniprotkb:Q9NUY1 intact:EBI-2511486|ensembl:ENSP00000341037|uniprotkb:Q8WXX2|uniprotkb:Q9UF86|uniprotkb:Q8NCN7|intact:EBI-11109494|uniprotkb:H0YJJ1|uniprotkb:Q86TU2|uniprotkb:B4DN18|uniprotkb:E7EUY8|uniprotkb:F8W9S4|uniprotkb:G3V2F8|uniprotkb:G3V5R0 psi-mi:phlp1_human(display_long)|uniprotkb:PHLPP1(gene name)|psi-mi:PHLPP1(display_short)|uniprotkb:KIAA0606(gene name synonym)|uniprotkb:PHLPP(gene name synonym)|uniprotkb:PLEKHE1(gene name synonym)|uniprotkb:SCOP(gene name synonym)|uniprotkb:Pleckstrin homology domain-containing family E member 1(gene name synonym)|uniprotkb:Suprachiasmatic nucleus circadian oscillatory protein(gene name synonym) psi-mi:wdr20_human(display_long)|uniprotkb:WDR20(gene name)|psi-mi:WDR20(display_short)|uniprotkb:Protein DMR(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514920|imex:IM-12079-95 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000262719|go:"GO:0009649"(entrainment of circadian clock)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046872"(metal ion binding)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1900744"(regulation of p38MAPK cascade)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001932(Protein phosphatase 2C-related)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR032675|interpro:IPR036457|mint:O60346|reactome:R-HSA-199418|ensembl:ENSG00000081913(gene)|ensembl:ENST00000262719(transcript)|go:"GO:0002667"(regulation of T cell anergy)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|refseq:NP_919431.2 ensembl:ENSG00000140153(gene)|ensembl:ENST00000342702(transcript)|go:"GO:0005654"(nucleoplasm)|interpro:IPR001680(WD40 repeat)|interpro:IPR036322|mint:Q8TBZ3|rcsb pdb:5K19|rcsb pdb:5K1C|rcsb pdb:6JLQ|reactome:R-HSA-5689880|refseq:NP_001229343.1|refseq:NP_001229345.1|refseq:NP_001229346.1|refseq:NP_001229347.1|refseq:NP_653175.2|refseq:NP_851808.1|refseq:NP_851825.1|refseq:NP_001229344.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:hPGjeSVMlJhO3o9YBWoBm9xppfk9606 rogid:2MfZps9YU8xQbWazkq2sIqXjHHg9606 intact-crc:2F9EF2D79BA0266C|rigid:s7RZr1AXICwqDpHxFUNW0lKe3BA false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O60346 uniprotkb:O75317 intact:EBI-2511516|intact:EBI-28974360|ensembl:ENSP00000262719|uniprotkb:Q6PJI6|uniprotkb:Q6P4C4|uniprotkb:A1A4F5|uniprotkb:Q641Q7|uniprotkb:Q86TN6|uniprotkb:Q96FK2|uniprotkb:Q9NUY1 intact:EBI-2511507|ensembl:ENSP00000282344|uniprotkb:Q8TC49|uniprotkb:Q5VZV3|uniprotkb:A8K0X0 psi-mi:phlp1_human(display_long)|uniprotkb:PHLPP1(gene name)|psi-mi:PHLPP1(display_short)|uniprotkb:KIAA0606(gene name synonym)|uniprotkb:PHLPP(gene name synonym)|uniprotkb:PLEKHE1(gene name synonym)|uniprotkb:SCOP(gene name synonym)|uniprotkb:Pleckstrin homology domain-containing family E member 1(gene name synonym)|uniprotkb:Suprachiasmatic nucleus circadian oscillatory protein(gene name synonym) psi-mi:ubp12_human(display_long)|uniprotkb:USP12(gene name)|psi-mi:USP12(display_short)|uniprotkb:UBH1(gene name synonym)|uniprotkb:USP12L1(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 12(gene name synonym)|uniprotkb:Deubiquitinating enzyme 12(gene name synonym)|uniprotkb:Ubiquitin-hydrolyzing enzyme 1(gene name synonym)|uniprotkb:Ubiquitin thioesterase 12(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514920|imex:IM-12079-95 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000262719|go:"GO:0009649"(entrainment of circadian clock)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046872"(metal ion binding)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1900744"(regulation of p38MAPK cascade)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001932(Protein phosphatase 2C-related)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR032675|interpro:IPR036457|mint:O60346|reactome:R-HSA-199418|ensembl:ENSG00000081913(gene)|ensembl:ENST00000262719(transcript)|go:"GO:0002667"(regulation of T cell anergy)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|refseq:NP_919431.2 ensembl:ENSG00000152484(gene)|ensembl:ENST00000282344(transcript)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0046872"(metal ion binding)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|mint:O75317|rcsb pdb:5K16|rcsb pdb:5K1A|rcsb pdb:5K1B|rcsb pdb:5K1C|rcsb pdb:5L8W|reactome:R-HSA-5689880|refseq:NP_872294.2 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:hPGjeSVMlJhO3o9YBWoBm9xppfk9606 rogid:SiueMBicjAsFl2OGlBfQ6tg1cf89606 intact-crc:2F9EF2D79BA0266C|rigid:s7RZr1AXICwqDpHxFUNW0lKe3BA false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O60346 uniprotkb:P62068 intact:EBI-2511516|intact:EBI-28974360|ensembl:ENSP00000262719|uniprotkb:Q6PJI6|uniprotkb:Q6P4C4|uniprotkb:A1A4F5|uniprotkb:Q641Q7|uniprotkb:Q86TN6|uniprotkb:Q96FK2|uniprotkb:Q9NUY1 intact:EBI-2512753|ensembl:ENSP00000407818|uniprotkb:B7Z675|uniprotkb:Q9H7U4|uniprotkb:B7Z7S3|uniprotkb:B7Z3Y7|uniprotkb:Q80V95|uniprotkb:Q9H9T8|uniprotkb:G8ACC7 psi-mi:phlp1_human(display_long)|uniprotkb:PHLPP1(gene name)|psi-mi:PHLPP1(display_short)|uniprotkb:KIAA0606(gene name synonym)|uniprotkb:PHLPP(gene name synonym)|uniprotkb:PLEKHE1(gene name synonym)|uniprotkb:SCOP(gene name synonym)|uniprotkb:Pleckstrin homology domain-containing family E member 1(gene name synonym)|uniprotkb:Suprachiasmatic nucleus circadian oscillatory protein(gene name synonym) psi-mi:ubp46_human(display_long)|uniprotkb:USP46(gene name)|psi-mi:USP46(display_short)|uniprotkb:Ubiquitin-specific-processing protease 46(gene name synonym)|uniprotkb:Deubiquitinating enzyme 46(gene name synonym)|uniprotkb:Ubiquitin thioesterase 46(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514920|imex:IM-12079-95 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000262719|go:"GO:0009649"(entrainment of circadian clock)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046872"(metal ion binding)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1900744"(regulation of p38MAPK cascade)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001932(Protein phosphatase 2C-related)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR032675|interpro:IPR036457|mint:O60346|reactome:R-HSA-199418|ensembl:ENSG00000081913(gene)|ensembl:ENST00000262719(transcript)|go:"GO:0002667"(regulation of T cell anergy)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|refseq:NP_919431.2 ensembl:ENSG00000109189(gene)|ensembl:ENST00000441222(transcript)|go:"GO:0001662"(behavioral fear response)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008343"(adult feeding behavior)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0032228"(regulation of synaptic transmission, GABAergic)|go:"GO:0046872"(metal ion binding)|go:"GO:0048149"(behavioral response to ethanol)|go:"GO:0060013"(righting reflex)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|mint:P62068|rcsb pdb:5CVM|rcsb pdb:5CVN|rcsb pdb:5CVO|rcsb pdb:5L8H|rcsb pdb:6JLQ|refseq:NP_001273696.1|refseq:NP_001273697.1|refseq:NP_001127695.1|refseq:NP_073743.2|dip:DIP-53590N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:hPGjeSVMlJhO3o9YBWoBm9xppfk9606 rogid:MYmLwHkGXhvq+vVvr88amlicCbg9606 intact-crc:2F9EF2D79BA0266C|rigid:s7RZr1AXICwqDpHxFUNW0lKe3BA false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O60346 uniprotkb:Q14160 intact:EBI-2511516|intact:EBI-28974360|ensembl:ENSP00000262719|uniprotkb:Q6PJI6|uniprotkb:Q6P4C4|uniprotkb:A1A4F5|uniprotkb:Q641Q7|uniprotkb:Q86TN6|uniprotkb:Q96FK2|uniprotkb:Q9NUY1 intact:EBI-357345|uniprotkb:Q6P496|uniprotkb:Q7Z5D1|uniprotkb:Q8WWV8|uniprotkb:Q96C69|uniprotkb:Q96GG1|ensembl:ENSP00000322938|ensembl:ENSP00000349486|ensembl:ENSP00000366756 psi-mi:phlp1_human(display_long)|uniprotkb:PHLPP1(gene name)|psi-mi:PHLPP1(display_short)|uniprotkb:KIAA0606(gene name synonym)|uniprotkb:PHLPP(gene name synonym)|uniprotkb:PLEKHE1(gene name synonym)|uniprotkb:SCOP(gene name synonym)|uniprotkb:Pleckstrin homology domain-containing family E member 1(gene name synonym)|uniprotkb:Suprachiasmatic nucleus circadian oscillatory protein(gene name synonym) psi-mi:scrib_human(display_long)|uniprotkb:SCRIB(gene name)|psi-mi:SCRIB(display_short)|uniprotkb:CRIB1(gene name synonym)|uniprotkb:KIAA0147(gene name synonym)|uniprotkb:LAP4(gene name synonym)|uniprotkb:SCRB1(gene name synonym)|uniprotkb:VARTUL(gene name synonym)|uniprotkb:Protein LAP4(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514920|imex:IM-12079-95 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000262719|go:"GO:0009649"(entrainment of circadian clock)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046872"(metal ion binding)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1900744"(regulation of p38MAPK cascade)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001932(Protein phosphatase 2C-related)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR032675|interpro:IPR036457|mint:O60346|reactome:R-HSA-199418|ensembl:ENSG00000081913(gene)|ensembl:ENST00000262719(transcript)|go:"GO:0002667"(regulation of T cell anergy)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|refseq:NP_919431.2 refseq:NP_056171.3|refseq:NP_874365.3|dip:DIP-31259N|ensembl:ENSG00000180900(gene)|ensembl:ENST00000320476(transcript)|ensembl:ENST00000356994(transcript)|ensembl:ENST00000377533(transcript)|go:"GO:0001768"(establishment of T cell polarity)|go:"GO:0001772"(immunological synapse)|go:"GO:0001843"(neural tube closure)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0008283"(cell population proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016080"(synaptic vesicle targeting)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016477"(cell migration)|go:"GO:0021747"(cochlear nucleus development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030054"(cell junction)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0030859"(polarized epithelial cell differentiation)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0034750"(Scrib-APC-beta-catenin complex)|go:"GO:0035089"(establishment of apical/basal cell polarity)|go:"GO:0035748"(myelin sheath abaxonal region)|go:"GO:0036342"(post-anal tail morphogenesis)|go:"GO:0039563"(suppression by virus of host JAK-STAT cascade via inhibition of STAT1 activity)|go:"GO:0039564"(suppression by virus of host JAK-STAT cascade via inhibition of STAT2 activity)|go:"GO:0042060"(wound healing)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043113"(receptor clustering)|go:"GO:0043615"(astrocyte cell migration)|go:"GO:0044291"(cell-cell contact zone)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0045296"(cadherin binding)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0050918"(positive chemotaxis)|go:"GO:0060088"(auditory receptor cell stereocilium organization)|go:"GO:0060561"(apoptotic process involved in morphogenesis)|go:"GO:0060603"(mammary gland duct morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071896"(protein localization to adherens junction)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098793"(presynapse)|go:"GO:0098887"(neurotransmitter receptor transport, endosome to postsynaptic membrane)|go:"GO:0098968"(neurotransmitter receptor transport postsynaptic membrane to endosome)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099147"(extrinsic component of postsynaptic density membrane)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR032675|interpro:IPR036034|mint:Q14160|rcsb pdb:1UJU|rcsb pdb:1WHA|rcsb pdb:1X5Q|rcsb pdb:2W4F|rcsb pdb:4WYT|rcsb pdb:4WYU|rcsb pdb:5VWC|rcsb pdb:5VWI|rcsb pdb:5VWK|rcsb pdb:6EEY|rcsb pdb:6ESP|rcsb pdb:6MS1|rcsb pdb:6MTU|rcsb pdb:6MTV|rcsb pdb:6MYE|rcsb pdb:6MYF|rcsb pdb:6XA6|rcsb pdb:6XA7|rcsb pdb:6XA8|rcsb pdb:7JO7|reactome:R-HSA-4608870|reactome:R-HSA-9013148|reactome:R-HSA-9013406|reactome:R-HSA-9013409|reactome:R-HSA-9696264|reactome:R-HSA-9696270 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:hPGjeSVMlJhO3o9YBWoBm9xppfk9606 rogid:y4lIQ2NivmndHYd/JXSKvU2jv+w9606 intact-crc:2F9EF2D79BA0266C|rigid:s7RZr1AXICwqDpHxFUNW0lKe3BA false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O60346 uniprotkb:Q9Y2Z0 intact:EBI-2511516|intact:EBI-28974360|ensembl:ENSP00000262719|uniprotkb:Q6PJI6|uniprotkb:Q6P4C4|uniprotkb:A1A4F5|uniprotkb:Q641Q7|uniprotkb:Q86TN6|uniprotkb:Q96FK2|uniprotkb:Q9NUY1 intact:EBI-307008|ensembl:ENSP00000367208|uniprotkb:Q5JAK5|uniprotkb:Q6VXY6|uniprotkb:A2A303|uniprotkb:Q5TAM6 psi-mi:phlp1_human(display_long)|uniprotkb:PHLPP1(gene name)|psi-mi:PHLPP1(display_short)|uniprotkb:KIAA0606(gene name synonym)|uniprotkb:PHLPP(gene name synonym)|uniprotkb:PLEKHE1(gene name synonym)|uniprotkb:SCOP(gene name synonym)|uniprotkb:Pleckstrin homology domain-containing family E member 1(gene name synonym)|uniprotkb:Suprachiasmatic nucleus circadian oscillatory protein(gene name synonym) psi-mi:sgt1_human(display_long)|uniprotkb:SUGT1(gene name)|psi-mi:SUGT1(display_short)|uniprotkb:Sgt1(gene name synonym)|uniprotkb:Protein 40-6-3(gene name synonym)|uniprotkb:Suppressor of G2 allele of SKP1 homolog(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514920|imex:IM-12079-95 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000262719|go:"GO:0009649"(entrainment of circadian clock)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046872"(metal ion binding)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1900744"(regulation of p38MAPK cascade)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001932(Protein phosphatase 2C-related)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR032675|interpro:IPR036457|mint:O60346|reactome:R-HSA-199418|ensembl:ENSG00000081913(gene)|ensembl:ENST00000262719(transcript)|go:"GO:0002667"(regulation of T cell anergy)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|refseq:NP_919431.2 reactome:R-HSA-9660826|ensembl:ENSG00000165416(gene)|ensembl:ENST00000343788(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000776"(kinetochore)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043947"(obsolete positive regulation by host of symbiont catalytic activity)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|interpro:IPR007052(CS domain)|interpro:IPR007699(SGS)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR044563|mint:Q9Y2Z0|rcsb pdb:1RL1|reactome:R-HSA-844456|refseq:NP_001124384.1|refseq:NP_006695.1|refseq:NP_001307760.1|dip:DIP-53799N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:hPGjeSVMlJhO3o9YBWoBm9xppfk9606 rogid:LZLjC25rgN9UOlExVzIfrWj8taE9606 intact-crc:2F9EF2D79BA0266C|rigid:s7RZr1AXICwqDpHxFUNW0lKe3BA false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O60346 uniprotkb:Q15599 intact:EBI-2511516|intact:EBI-28974360|ensembl:ENSP00000262719|uniprotkb:Q6PJI6|uniprotkb:Q6P4C4|uniprotkb:A1A4F5|uniprotkb:Q641Q7|uniprotkb:Q86TN6|uniprotkb:Q96FK2|uniprotkb:Q9NUY1 intact:EBI-1149760|uniprotkb:O00272|uniprotkb:O00556|uniprotkb:Q3KQY7|uniprotkb:D3DU84|uniprotkb:D3DU85|uniprotkb:H3BSV6|ensembl:ENSP00000408005|intact:EBI-15579694 psi-mi:phlp1_human(display_long)|uniprotkb:PHLPP1(gene name)|psi-mi:PHLPP1(display_short)|uniprotkb:KIAA0606(gene name synonym)|uniprotkb:PHLPP(gene name synonym)|uniprotkb:PLEKHE1(gene name synonym)|uniprotkb:SCOP(gene name synonym)|uniprotkb:Pleckstrin homology domain-containing family E member 1(gene name synonym)|uniprotkb:Suprachiasmatic nucleus circadian oscillatory protein(gene name synonym) psi-mi:nhrf2_human(display_long)|uniprotkb:SLC9A3R2(gene name)|psi-mi:SLC9A3R2(display_short)|uniprotkb:NHERF2(gene name synonym)|uniprotkb:Tyrosine kinase activator protein 1(gene name synonym)|uniprotkb:SRY-interacting protein 1(gene name synonym)|uniprotkb:Solute carrier family 9 isoform A3 regulatory factor 2(gene name synonym)|uniprotkb:NHE3 kinase A regulatory protein E3KARP(gene name synonym)|uniprotkb:Sodium-hydrogen exchanger regulatory factor 2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514920|imex:IM-12079-95 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000262719|go:"GO:0009649"(entrainment of circadian clock)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046872"(metal ion binding)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1900744"(regulation of p38MAPK cascade)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001932(Protein phosphatase 2C-related)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR032675|interpro:IPR036457|mint:O60346|reactome:R-HSA-199418|ensembl:ENSG00000081913(gene)|ensembl:ENST00000262719(transcript)|go:"GO:0002667"(regulation of T cell anergy)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|refseq:NP_919431.2 refseq:NP_001123484.1|refseq:NP_004776.3|refseq:NP_001239002.1|ensembl:ENSG00000065054(gene)|ensembl:ENST00000424542(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0012505"(endomembrane system)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019902"(phosphatase binding)|go:"GO:0031799"(type 2 metabotropic glutamate receptor binding)|go:"GO:0031800"(type 3 metabotropic glutamate receptor binding)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0045296"(cadherin binding)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072659"(protein localization to plasma membrane)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR015098(EBP50, C-terminal)|interpro:IPR017300("Na(+)/H(+) exchange regulatory cofactor NHE-RF")|interpro:IPR031197|interpro:IPR036034|mint:Q15599|rcsb pdb:2D11|rcsb pdb:2HE4|rcsb pdb:2OCS|rcsb pdb:4P0C|go:"GO:0042802"(identical protein binding)|dip:DIP-29093N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:hPGjeSVMlJhO3o9YBWoBm9xppfk9606 rogid:BRqFx6BigKEZV84KUdfvppEXg+s9606 intact-crc:2F9EF2D79BA0266C|rigid:s7RZr1AXICwqDpHxFUNW0lKe3BA false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O60346 uniprotkb:O94782 intact:EBI-2511516|intact:EBI-28974360|ensembl:ENSP00000262719|uniprotkb:Q6PJI6|uniprotkb:Q6P4C4|uniprotkb:A1A4F5|uniprotkb:Q641Q7|uniprotkb:Q86TN6|uniprotkb:Q96FK2|uniprotkb:Q9NUY1 intact:EBI-2513396|ensembl:ENSP00000343526|ensembl:ENSP00000360188|uniprotkb:Q9UNJ3|uniprotkb:A0PJ95|uniprotkb:Q9UFR0|uniprotkb:Q59H66|uniprotkb:Q05BX7|uniprotkb:D3DQ57 psi-mi:phlp1_human(display_long)|uniprotkb:PHLPP1(gene name)|psi-mi:PHLPP1(display_short)|uniprotkb:KIAA0606(gene name synonym)|uniprotkb:PHLPP(gene name synonym)|uniprotkb:PLEKHE1(gene name synonym)|uniprotkb:SCOP(gene name synonym)|uniprotkb:Pleckstrin homology domain-containing family E member 1(gene name synonym)|uniprotkb:Suprachiasmatic nucleus circadian oscillatory protein(gene name synonym) psi-mi:ubp1_human(display_long)|uniprotkb:USP1(gene name)|psi-mi:USP1(display_short)|uniprotkb:Ubiquitin-specific-processing protease 1(gene name synonym)|uniprotkb:Deubiquitinating enzyme 1(gene name synonym)|uniprotkb:Ubiquitin thioesterase 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514920|imex:IM-12079-95 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000262719|go:"GO:0009649"(entrainment of circadian clock)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046872"(metal ion binding)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1900744"(regulation of p38MAPK cascade)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001932(Protein phosphatase 2C-related)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR032675|interpro:IPR036457|mint:O60346|reactome:R-HSA-199418|ensembl:ENSG00000081913(gene)|ensembl:ENST00000262719(transcript)|go:"GO:0002667"(regulation of T cell anergy)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|refseq:NP_919431.2 ensembl:ENSG00000162607(gene)|ensembl:ENST00000339950(transcript)|ensembl:ENST00000371146(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008233"(peptidase activity)|go:"GO:0009411"(response to UV)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035520"(monoubiquitinated protein deubiquitination)|go:"GO:0042769"(obsolete DNA damage response, detection of DNA damage)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR033815|interpro:IPR038765|mint:O94782|rcsb pdb:6DO5|rcsb pdb:7AY0|rcsb pdb:7AY1|rcsb pdb:7AY2|reactome:R-HSA-110314|reactome:R-HSA-6783310|refseq:NP_001017415.1|refseq:NP_001017416.1|refseq:NP_003359.3|dip:DIP-53609N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:hPGjeSVMlJhO3o9YBWoBm9xppfk9606 rogid:cSWX5JiI+vqbREjhCJeCGAiiVzE9606 intact-crc:2F9EF2D79BA0266C|rigid:s7RZr1AXICwqDpHxFUNW0lKe3BA false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43172 uniprotkb:Q9BUQ8 intact:EBI-718395|uniprotkb:O43445|uniprotkb:O43864|uniprotkb:Q96DG2|uniprotkb:Q96IK4|uniprotkb:Q5T1M8|ensembl:ENSP00000363315 intact:EBI-540096|uniprotkb:B2R600|uniprotkb:O43188|uniprotkb:B4DH15|intact:EBI-2557638|ensembl:ENSP00000310723 psi-mi:prp4_human(display_long)|uniprotkb:U4/U6 snRNP 60 kDa protein(gene name synonym)|uniprotkb:WD splicing factor Prp4(gene name synonym)|uniprotkb:PRP4 homolog(gene name synonym)|uniprotkb:PRPF4(gene name)|psi-mi:PRPF4(display_short)|uniprotkb:PRP4(gene name synonym) psi-mi:ddx23_human(display_long)|uniprotkb:DEAD box protein 23(gene name synonym)|uniprotkb:100 kDa U5 snRNP-specific protein(gene name synonym)|uniprotkb:U5-100kD(gene name synonym)|uniprotkb:PRP28 homolog(gene name synonym)|uniprotkb:DDX23(gene name)|psi-mi:DDX23(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514971|imex:IM-12079-45 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004688.2|refseq:NP_001231855.1|ensembl:ENSG00000136875(gene)|ensembl:ENST00000374199(transcript)|go:"GO:0000375"(RNA splicing, via transesterification reactions)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0071001"(U4/U6 snRNP)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0097525"(spliceosomal snRNP complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR014906("Pre-mRNA processing factor 4 (PRP4) like")|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|interpro:IPR015943(WD40/YVTN repeat-like)|go:"GO:0006396"(RNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0015030"(Cajal body)|go:"GO:0016607"(nuclear speck)|go:"GO:0017070"(U6 snRNA binding)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036285|interpro:IPR036322|mint:O43172|rcsb pdb:1MZW|rcsb pdb:3JCR|rcsb pdb:5O9Z|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6QW6|rcsb pdb:6QX9|reactome:R-HSA-72163|go:"GO:0030621"(U4 snRNA binding) refseq:NP_004809.2|ensembl:ENSG00000174243(gene)|ensembl:ENST00000308025(transcript)|go:"GO:0000354"(cis assembly of pre-catalytic spliceosome)|go:"GO:0000375"(RNA splicing, via transesterification reactions)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000785"(chromatin)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005682"(U5 snRNP)|go:"GO:0005730"(nucleolus)|go:"GO:0008380"(RNA splicing)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0062176"(R-loop disassembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR000629(RNA helicase, ATP-dependent, DEAD-box, conserved site)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|mint:Q9BUQ8|rcsb pdb:3JCR|rcsb pdb:4NHO|rcsb pdb:6AH0|rcsb pdb:6QW6|rcsb pdb:6QX9|reactome:R-HSA-72163|reactome:R-HSA-72165|dip:DIP-34974N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/04/15 rogid:PPTNuhEFj4D+gTv/ctTTMzGmFA09606 rogid:tEDp48akFaCjRBBXB4jtyrAsLQ89606 intact-crc:A1F03D1DEDBF9802|rigid:zKE4/djkX/Vt9cK7sgq837rnkyY false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43172 uniprotkb:Q96DI7 intact:EBI-718395|uniprotkb:O43445|uniprotkb:O43864|uniprotkb:Q96DG2|uniprotkb:Q96IK4|uniprotkb:Q5T1M8|ensembl:ENSP00000363315 intact:EBI-538492|uniprotkb:O75938|uniprotkb:O95320|uniprotkb:B4DQJ1|ensembl:ENSP00000263694 psi-mi:prp4_human(display_long)|uniprotkb:U4/U6 snRNP 60 kDa protein(gene name synonym)|uniprotkb:WD splicing factor Prp4(gene name synonym)|uniprotkb:PRP4 homolog(gene name synonym)|uniprotkb:PRPF4(gene name)|psi-mi:PRPF4(display_short)|uniprotkb:PRP4(gene name synonym) psi-mi:snr40_human(display_long)|uniprotkb:Prp8-binding protein(gene name synonym)|uniprotkb:U5 snRNP-specific 40 kDa protein(gene name synonym)|uniprotkb:38 kDa-splicing factor(gene name synonym)|uniprotkb:SNRNP40(gene name)|psi-mi:SNRNP40(display_short)|uniprotkb:PRP8BP(gene name synonym)|uniprotkb:SFP38(gene name synonym)|uniprotkb:WDR57(gene name synonym)|uniprotkb:WD repeat-containing protein 57(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514971|imex:IM-12079-45 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004688.2|refseq:NP_001231855.1|ensembl:ENSG00000136875(gene)|ensembl:ENST00000374199(transcript)|go:"GO:0000375"(RNA splicing, via transesterification reactions)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0071001"(U4/U6 snRNP)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0097525"(spliceosomal snRNP complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR014906("Pre-mRNA processing factor 4 (PRP4) like")|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|interpro:IPR015943(WD40/YVTN repeat-like)|go:"GO:0006396"(RNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0015030"(Cajal body)|go:"GO:0016607"(nuclear speck)|go:"GO:0017070"(U6 snRNA binding)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036285|interpro:IPR036322|mint:O43172|rcsb pdb:1MZW|rcsb pdb:3JCR|rcsb pdb:5O9Z|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6QW6|rcsb pdb:6QX9|reactome:R-HSA-72163|go:"GO:0030621"(U4 snRNA binding) refseq:NP_004805.2|ensembl:ENSG00000060688(gene)|ensembl:ENST00000263694(transcript)|go:"GO:0000375"(RNA splicing, via transesterification reactions)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005682"(U5 snRNP)|go:"GO:0005732"("sno(s)RNA-containing ribonucleoprotein complex")|go:"GO:0005829"(cytosol)|go:"GO:0006396"(RNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0016607"(nuclear speck)|go:"GO:0071007"(U2-type catalytic step 2 spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|mint:Q96DI7|rcsb pdb:3JCR|rcsb pdb:5MQF|rcsb pdb:5O9Z|rcsb pdb:5XJC|rcsb pdb:5YZG|rcsb pdb:5Z56|rcsb pdb:5Z57|rcsb pdb:5Z58|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6FF7|rcsb pdb:6ICZ|rcsb pdb:6ID0|rcsb pdb:6ID1|rcsb pdb:6QDV|rcsb pdb:6QW6|rcsb pdb:6QX9|rcsb pdb:6ZYM|rcsb pdb:7ABG|rcsb pdb:7ABI|rcsb pdb:7DVQ|reactome:R-HSA-72163|reactome:R-HSA-72165 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/04/15 rogid:PPTNuhEFj4D+gTv/ctTTMzGmFA09606 rogid:AfLoHYSy0MlW+OqHyEULLcpwQhQ9606 intact-crc:A1F03D1DEDBF9802|rigid:zKE4/djkX/Vt9cK7sgq837rnkyY false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43172 uniprotkb:Q6P2Q9 intact:EBI-718395|uniprotkb:O43445|uniprotkb:O43864|uniprotkb:Q96DG2|uniprotkb:Q96IK4|uniprotkb:Q5T1M8|ensembl:ENSP00000363315 intact:EBI-538479|uniprotkb:O14547|uniprotkb:O75965|ensembl:ENSP00000304350|ensembl:ENSP00000460348|ensembl:ENSP00000479194|ensembl:ENSP00000488611 psi-mi:prp4_human(display_long)|uniprotkb:U4/U6 snRNP 60 kDa protein(gene name synonym)|uniprotkb:WD splicing factor Prp4(gene name synonym)|uniprotkb:PRP4 homolog(gene name synonym)|uniprotkb:PRPF4(gene name)|psi-mi:PRPF4(display_short)|uniprotkb:PRP4(gene name synonym) psi-mi:prp8_human(display_long)|uniprotkb:Splicing factor Prp8(gene name synonym)|uniprotkb:PRP8 homolog(gene name synonym)|uniprotkb:220 kDa U5 snRNP-specific protein(gene name synonym)|uniprotkb:p220(gene name synonym)|uniprotkb:PRPC8(gene name synonym)|uniprotkb:PRPF8(gene name)|psi-mi:PRPF8(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514971|imex:IM-12079-45 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004688.2|refseq:NP_001231855.1|ensembl:ENSG00000136875(gene)|ensembl:ENST00000374199(transcript)|go:"GO:0000375"(RNA splicing, via transesterification reactions)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0071001"(U4/U6 snRNP)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0097525"(spliceosomal snRNP complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR014906("Pre-mRNA processing factor 4 (PRP4) like")|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|interpro:IPR015943(WD40/YVTN repeat-like)|go:"GO:0006396"(RNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0015030"(Cajal body)|go:"GO:0016607"(nuclear speck)|go:"GO:0017070"(U6 snRNA binding)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036285|interpro:IPR036322|mint:O43172|rcsb pdb:1MZW|rcsb pdb:3JCR|rcsb pdb:5O9Z|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6QW6|rcsb pdb:6QX9|reactome:R-HSA-72163|go:"GO:0030621"(U4 snRNA binding) refseq:NP_006436.3|ensembl:ENSG00000174231(gene)|ensembl:ENSG00000274442(gene)|ensembl:ENST00000304992(transcript)|ensembl:ENST00000572621(transcript)|ensembl:ENST00000614672(transcript)|ensembl:ENST00000634039(transcript)|go:"GO:0000244"(spliceosomal tri-snRNP complex assembly)|go:"GO:0000375"(RNA splicing, via transesterification reactions)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005682"(U5 snRNP)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0017070"(U6 snRNA binding)|go:"GO:0030619"(U1 snRNA binding)|go:"GO:0030620"(U2 snRNA binding)|go:"GO:0030623"(U5 snRNA binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0070122"(isopeptidase activity)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071006"(U2-type catalytic step 1 spliceosome)|go:"GO:0071007"(U2-type catalytic step 2 spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0097157"(pre-mRNA intronic binding)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR012591(PRO8NT)|interpro:IPR012592(PROCN)|interpro:IPR012984(PRO, C-terminal)|interpro:IPR019580|interpro:IPR019581|interpro:IPR019582|interpro:IPR021983|interpro:IPR027652|interpro:IPR037518|interpro:IPR042516|interpro:IPR043172|interpro:IPR043173|mint:Q6P2Q9|rcsb pdb:3E9L|rcsb pdb:3ENB|rcsb pdb:3JCR|rcsb pdb:3LRU|rcsb pdb:4JK7|rcsb pdb:4JK8|rcsb pdb:4JK9|rcsb pdb:4JKA|rcsb pdb:4JKB|rcsb pdb:4JKC|rcsb pdb:4JKD|rcsb pdb:4JKE|rcsb pdb:4JKF|rcsb pdb:4JKG|rcsb pdb:4JKH|rcsb pdb:4KIT|rcsb pdb:5MQF|rcsb pdb:5O9Z|rcsb pdb:5YZG|rcsb pdb:5Z56|rcsb pdb:5Z57|rcsb pdb:5Z58|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6FF4|rcsb pdb:6FF7|rcsb pdb:6ICZ|rcsb pdb:6ID0|rcsb pdb:6ID1|rcsb pdb:6QDV|rcsb pdb:6QW6|rcsb pdb:6QX9|rcsb pdb:6S8Q|rcsb pdb:6S9I|rcsb pdb:6ZYM|rcsb pdb:7A5P|rcsb pdb:7AAV|rcsb pdb:7ABF|rcsb pdb:7ABG|rcsb pdb:7ABI|rcsb pdb:7BDI|rcsb pdb:7BDJ|rcsb pdb:7BDK|rcsb pdb:7BDL|rcsb pdb:7DVQ|reactome:R-HSA-72163|reactome:R-HSA-72165|rcsb pdb:5XJC|dip:DIP-29614N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/04/15 rogid:PPTNuhEFj4D+gTv/ctTTMzGmFA09606 rogid:I0ot8b3pvieXRI66omFm145sGVA9606 intact-crc:A1F03D1DEDBF9802|rigid:zKE4/djkX/Vt9cK7sgq837rnkyY false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43172 uniprotkb:Q7L2J0 intact:EBI-718395|uniprotkb:O43445|uniprotkb:O43864|uniprotkb:Q96DG2|uniprotkb:Q96IK4|uniprotkb:Q5T1M8|ensembl:ENSP00000363315 intact:EBI-2371983|uniprotkb:Q9NPD4|uniprotkb:B3KP86|uniprotkb:D6W5V7|ensembl:ENSP00000308546 psi-mi:prp4_human(display_long)|uniprotkb:U4/U6 snRNP 60 kDa protein(gene name synonym)|uniprotkb:WD splicing factor Prp4(gene name synonym)|uniprotkb:PRP4 homolog(gene name synonym)|uniprotkb:PRPF4(gene name)|psi-mi:PRPF4(display_short)|uniprotkb:PRP4(gene name synonym) psi-mi:mepce_human(display_long)|uniprotkb:MEPCE(gene name)|psi-mi:MEPCE(display_short)|uniprotkb:BCDIN3(gene name synonym)|uniprotkb:Bicoid-interacting protein 3 homolog(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514971|imex:IM-12079-45 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004688.2|refseq:NP_001231855.1|ensembl:ENSG00000136875(gene)|ensembl:ENST00000374199(transcript)|go:"GO:0000375"(RNA splicing, via transesterification reactions)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0071001"(U4/U6 snRNP)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0097525"(spliceosomal snRNP complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR014906("Pre-mRNA processing factor 4 (PRP4) like")|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|interpro:IPR015943(WD40/YVTN repeat-like)|go:"GO:0006396"(RNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0015030"(Cajal body)|go:"GO:0016607"(nuclear speck)|go:"GO:0017070"(U6 snRNA binding)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036285|interpro:IPR036322|mint:O43172|rcsb pdb:1MZW|rcsb pdb:3JCR|rcsb pdb:5O9Z|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6QW6|rcsb pdb:6QX9|reactome:R-HSA-72163|go:"GO:0030621"(U4 snRNA binding) refseq:XP_011514712.1|refseq:NP_001181919.1|refseq:NP_001181920.1|refseq:NP_001181921.1|refseq:NP_062552.2|ensembl:ENSG00000146834(gene)|ensembl:ENST00000310512(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001510"(RNA methylation)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0008171"(O-methyltransferase activity)|go:"GO:0008173"(RNA methyltransferase activity)|go:"GO:0008757"(S-adenosylmethionine-dependent methyltransferase activity)|go:"GO:0016073"(snRNA metabolic process)|go:"GO:0017069"(snRNA binding)|go:"GO:0035562"(negative regulation of chromatin binding)|go:"GO:0040031"(snRNA modification)|go:"GO:0097322"(7SK snRNA binding)|go:"GO:0120259"(7SK snRNP)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1904871"(positive regulation of protein localization to Cajal body)|go:"GO:1905382"(positive regulation of snRNA transcription by RNA polymerase II)|go:"GO:1990276"(RNA 5'-methyltransferase activity)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR010675(Bicoid-interacting 3)|interpro:IPR024160|interpro:IPR025714|interpro:IPR029063|interpro:IPR039772|mint:Q7L2J0|rcsb pdb:5UNA|rcsb pdb:6DCB|rcsb pdb:6DCC psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/04/15 rogid:PPTNuhEFj4D+gTv/ctTTMzGmFA09606 rogid:VGhJoO3FD7nsJPVSBsKuKsPJzEM9606 intact-crc:A1F03D1DEDBF9802|rigid:zKE4/djkX/Vt9cK7sgq837rnkyY false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43172 uniprotkb:P83876 intact:EBI-718395|uniprotkb:O43445|uniprotkb:O43864|uniprotkb:Q96DG2|uniprotkb:Q96IK4|uniprotkb:Q5T1M8|ensembl:ENSP00000363315 intact:EBI-746539|uniprotkb:O14834|uniprotkb:B2RC18|ensembl:ENSP00000269601 psi-mi:prp4_human(display_long)|uniprotkb:U4/U6 snRNP 60 kDa protein(gene name synonym)|uniprotkb:WD splicing factor Prp4(gene name synonym)|uniprotkb:PRP4 homolog(gene name synonym)|uniprotkb:PRPF4(gene name)|psi-mi:PRPF4(display_short)|uniprotkb:PRP4(gene name synonym) psi-mi:txn4a_human(display_long)|uniprotkb:Thioredoxin-like U5 snRNP protein U5-15kD(gene name synonym)|uniprotkb:Spliceosomal U5 snRNP-specific 15 kDa protein(gene name synonym)|uniprotkb:DIM1 protein homolog(gene name synonym)|uniprotkb:TXNL4A(gene name)|psi-mi:TXNL4A(display_short)|uniprotkb:DIM1(gene name synonym)|uniprotkb:TXNL4(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514971|imex:IM-12079-45 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004688.2|refseq:NP_001231855.1|ensembl:ENSG00000136875(gene)|ensembl:ENST00000374199(transcript)|go:"GO:0000375"(RNA splicing, via transesterification reactions)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0071001"(U4/U6 snRNP)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0097525"(spliceosomal snRNP complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR014906("Pre-mRNA processing factor 4 (PRP4) like")|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|interpro:IPR015943(WD40/YVTN repeat-like)|go:"GO:0006396"(RNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0015030"(Cajal body)|go:"GO:0016607"(nuclear speck)|go:"GO:0017070"(U6 snRNA binding)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036285|interpro:IPR036322|mint:O43172|rcsb pdb:1MZW|rcsb pdb:3JCR|rcsb pdb:5O9Z|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6QW6|rcsb pdb:6QX9|reactome:R-HSA-72163|go:"GO:0030621"(U4 snRNA binding) refseq:NP_006692.1|refseq:NP_001290400.1|refseq:NP_001292486.1|refseq:NP_001292492.1|refseq:NP_001292493.1|ensembl:ENSG00000141759(gene)|ensembl:ENST00000269601(transcript)|go:"GO:0000245"(spliceosomal complex assembly)|go:"GO:0000375"(RNA splicing, via transesterification reactions)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005829"(cytosol)|go:"GO:0007049"(cell cycle)|go:"GO:0031965"(nuclear membrane)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0051301"(cell division)|go:"GO:0071005"(U2-type precatalytic spliceosome)|interpro:IPR004123(mRNA splicing factor, thioredoxin-like U5 snRNP)|interpro:IPR036249|rcsb pdb:1PQN|rcsb pdb:1QGV|rcsb pdb:1SYX|rcsb pdb:3JCR|rcsb pdb:4BWQ|rcsb pdb:4BWS|rcsb pdb:4CDO|rcsb pdb:5O9Z|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6QW6|rcsb pdb:6QX9|reactome:R-HSA-72163|reactome:R-HSA-72165|go:"GO:0005682"(U5 snRNP) psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/04/15 rogid:PPTNuhEFj4D+gTv/ctTTMzGmFA09606 rogid:gGYj9Meks26JpYxw6wB5S2vIrkE9606 intact-crc:A1F03D1DEDBF9802|rigid:zKE4/djkX/Vt9cK7sgq837rnkyY false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43172 uniprotkb:Q9NQP4 intact:EBI-718395|uniprotkb:O43445|uniprotkb:O43864|uniprotkb:Q96DG2|uniprotkb:Q96IK4|uniprotkb:Q5T1M8|ensembl:ENSP00000363315 intact:EBI-357021|uniprotkb:Q5TD11|uniprotkb:Q92779|ensembl:ENSP00000360473 psi-mi:prp4_human(display_long)|uniprotkb:U4/U6 snRNP 60 kDa protein(gene name synonym)|uniprotkb:WD splicing factor Prp4(gene name synonym)|uniprotkb:PRP4 homolog(gene name synonym)|uniprotkb:PRPF4(gene name)|psi-mi:PRPF4(display_short)|uniprotkb:PRP4(gene name synonym) psi-mi:pfd4_human(display_long)|uniprotkb:PFDN4(gene name)|psi-mi:PFDN4(display_short)|uniprotkb:PFD4(gene name synonym)|uniprotkb:Protein C-1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514971|imex:IM-12079-45 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004688.2|refseq:NP_001231855.1|ensembl:ENSG00000136875(gene)|ensembl:ENST00000374199(transcript)|go:"GO:0000375"(RNA splicing, via transesterification reactions)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0071001"(U4/U6 snRNP)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0097525"(spliceosomal snRNP complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR014906("Pre-mRNA processing factor 4 (PRP4) like")|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|interpro:IPR015943(WD40/YVTN repeat-like)|go:"GO:0006396"(RNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0015030"(Cajal body)|go:"GO:0016607"(nuclear speck)|go:"GO:0017070"(U6 snRNA binding)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036285|interpro:IPR036322|mint:O43172|rcsb pdb:1MZW|rcsb pdb:3JCR|rcsb pdb:5O9Z|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6QW6|rcsb pdb:6QX9|reactome:R-HSA-72163|go:"GO:0030621"(U4 snRNA binding) refseq:NP_002614.2|ensembl:ENSG00000101132(gene)|ensembl:ENST00000371419(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0016272"(prefoldin complex)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:1905907"(negative regulation of amyloid fibril formation)|interpro:IPR002777(Prefoldin beta-like)|interpro:IPR009053(Prefoldin)|interpro:IPR016661(Prefoldin, subunit 4)|mint:Q9NQP4|rcsb pdb:6NR8|rcsb pdb:6NR9|rcsb pdb:6NRB|rcsb pdb:6NRC|rcsb pdb:6NRD|reactome:R-HSA-389957 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/04/15 rogid:PPTNuhEFj4D+gTv/ctTTMzGmFA09606 rogid:oXbJiHxqcYHrAWGGgzV81ocGt889606 intact-crc:A1F03D1DEDBF9802|rigid:zKE4/djkX/Vt9cK7sgq837rnkyY false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43172 uniprotkb:Q99471 intact:EBI-718395|uniprotkb:O43445|uniprotkb:O43864|uniprotkb:Q96DG2|uniprotkb:Q96IK4|uniprotkb:Q5T1M8|ensembl:ENSP00000363315 intact:EBI-357275|ensembl:ENSP00000334188|ensembl:ENSP00000447942|intact:EBI-1047551|uniprotkb:A8K9A8|uniprotkb:Q54AA8|uniprotkb:Q9C083|uniprotkb:Q9C084 psi-mi:prp4_human(display_long)|uniprotkb:U4/U6 snRNP 60 kDa protein(gene name synonym)|uniprotkb:WD splicing factor Prp4(gene name synonym)|uniprotkb:PRP4 homolog(gene name synonym)|uniprotkb:PRPF4(gene name)|psi-mi:PRPF4(display_short)|uniprotkb:PRP4(gene name synonym) psi-mi:pfd5_human(display_long)|uniprotkb:c-Myc-binding protein Mm-1(gene name synonym)|uniprotkb:PFDN5(gene name)|psi-mi:PFDN5(display_short)|uniprotkb:MM1(gene name synonym)|uniprotkb:Myc modulator 1(gene name synonym)|uniprotkb:PFD5(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514971|imex:IM-12079-45 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004688.2|refseq:NP_001231855.1|ensembl:ENSG00000136875(gene)|ensembl:ENST00000374199(transcript)|go:"GO:0000375"(RNA splicing, via transesterification reactions)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0071001"(U4/U6 snRNP)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0097525"(spliceosomal snRNP complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR014906("Pre-mRNA processing factor 4 (PRP4) like")|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|interpro:IPR015943(WD40/YVTN repeat-like)|go:"GO:0006396"(RNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0015030"(Cajal body)|go:"GO:0016607"(nuclear speck)|go:"GO:0017070"(U6 snRNA binding)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036285|interpro:IPR036322|mint:O43172|rcsb pdb:1MZW|rcsb pdb:3JCR|rcsb pdb:5O9Z|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6QW6|rcsb pdb:6QX9|reactome:R-HSA-72163|go:"GO:0030621"(U4 snRNA binding) ensembl:ENSG00000123349(gene)|ensembl:ENST00000334478(transcript)|ensembl:ENST00000551018(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006457"(protein folding)|go:"GO:0016272"(prefoldin complex)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1905907"(negative regulation of amyloid fibril formation)|interpro:IPR004127(Prefoldin alpha-like)|interpro:IPR009053(Prefoldin)|interpro:IPR011599(Prefoldin alpha subunit)|mint:Q99471|rcsb pdb:6NR8|rcsb pdb:6NR9|rcsb pdb:6NRB|rcsb pdb:6NRC|rcsb pdb:6NRD|reactome:R-HSA-389957|refseq:NP_002615.2|refseq:NP_665904.1|dip:DIP-28155N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/04/15 rogid:PPTNuhEFj4D+gTv/ctTTMzGmFA09606 rogid:Cm4km207qcfDJYRUCIwUxMBT4tE9606 intact-crc:A1F03D1DEDBF9802|rigid:zKE4/djkX/Vt9cK7sgq837rnkyY false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43172 uniprotkb:Q13523 intact:EBI-718395|uniprotkb:O43445|uniprotkb:O43864|uniprotkb:Q96DG2|uniprotkb:Q96IK4|uniprotkb:Q5T1M8|ensembl:ENSP00000363315 intact:EBI-395940|uniprotkb:Q8TDP2|uniprotkb:Q96QT7|uniprotkb:Q9UEE6|uniprotkb:Q5TAY8|uniprotkb:A8K5C9|uniprotkb:Q5D0F6|uniprotkb:Q8IVC3|intact:EBI-1058380|ensembl:ENSP00000337194|ensembl:ENSP00000433547 psi-mi:prp4_human(display_long)|uniprotkb:U4/U6 snRNP 60 kDa protein(gene name synonym)|uniprotkb:WD splicing factor Prp4(gene name synonym)|uniprotkb:PRP4 homolog(gene name synonym)|uniprotkb:PRPF4(gene name)|psi-mi:PRPF4(display_short)|uniprotkb:PRP4(gene name synonym) psi-mi:prp4b_human(display_long)|uniprotkb:PRPF4B(gene name)|psi-mi:PRPF4B(display_short)|uniprotkb:KIAA0536(gene name synonym)|uniprotkb:PRP4(gene name synonym)|uniprotkb:PRP4H(gene name synonym)|uniprotkb:PRP4K(gene name synonym)|uniprotkb:PRP4 pre-mRNA-processing factor 4 homolog(gene name synonym)|uniprotkb:PRP4 kinase(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514971|imex:IM-12079-45 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004688.2|refseq:NP_001231855.1|ensembl:ENSG00000136875(gene)|ensembl:ENST00000374199(transcript)|go:"GO:0000375"(RNA splicing, via transesterification reactions)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0071001"(U4/U6 snRNP)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0097525"(spliceosomal snRNP complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR014906("Pre-mRNA processing factor 4 (PRP4) like")|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|interpro:IPR015943(WD40/YVTN repeat-like)|go:"GO:0006396"(RNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0015030"(Cajal body)|go:"GO:0016607"(nuclear speck)|go:"GO:0017070"(U6 snRNA binding)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036285|interpro:IPR036322|mint:O43172|rcsb pdb:1MZW|rcsb pdb:3JCR|rcsb pdb:5O9Z|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6QW6|rcsb pdb:6QX9|reactome:R-HSA-72163|go:"GO:0030621"(U4 snRNA binding) refseq:NP_003904.3|ensembl:ENSG00000112739(gene)|ensembl:ENST00000337659(transcript)|ensembl:ENST00000480058(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008380"(RNA splicing)|go:"GO:0016607"(nuclear speck)|go:"GO:0045292"(mRNA cis splicing, via spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR044092|mint:Q13523|rcsb pdb:4IAN|rcsb pdb:4IFC|rcsb pdb:4IIR|rcsb pdb:4IJP|rcsb pdb:6CNH|rcsb pdb:6PJJ|rcsb pdb:6PK6|rcsb pdb:6QX9|refseq:XP_016866899.1|refseq:XP_016866900.1|refseq:XP_016866901.1|refseq:XP_016866902.1|refseq:XP_016866903.1|refseq:XP_016866904.1|refseq:XP_016866905.1|refseq:XP_016866906.1|refseq:XP_016866907.1|refseq:XP_016866908.1|refseq:XP_016866909.1|refseq:XP_016866910.1|refseq:XP_016866911.1|refseq:XP_016866912.1|refseq:XP_016866913.1|refseq:XP_016866914.1|refseq:XP_016866915.1|refseq:XP_016866916.1|refseq:XP_016866917.1|refseq:XP_016866918.1|refseq:XP_016866919.1|refseq:XP_016866920.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/04/15 rogid:PPTNuhEFj4D+gTv/ctTTMzGmFA09606 rogid:ZklPbRvRbbVRJYqV3JkS2jG3EIc9606 intact-crc:A1F03D1DEDBF9802|rigid:zKE4/djkX/Vt9cK7sgq837rnkyY false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43172 uniprotkb:O43447 intact:EBI-718395|uniprotkb:O43445|uniprotkb:O43864|uniprotkb:Q96DG2|uniprotkb:Q96IK4|uniprotkb:Q5T1M8|ensembl:ENSP00000363315 intact:EBI-1055615|intact:EBI-6190037|uniprotkb:A6NNE7|ensembl:ENSP00000503384|ensembl:ENSP00000503489|ensembl:ENSP00000503922|ensembl:ENSP00000504108|ensembl:ENSP00000504595|ensembl:ENSP00000361630|ensembl:ENSP00000306614 psi-mi:prp4_human(display_long)|uniprotkb:U4/U6 snRNP 60 kDa protein(gene name synonym)|uniprotkb:WD splicing factor Prp4(gene name synonym)|uniprotkb:PRP4 homolog(gene name synonym)|uniprotkb:PRPF4(gene name)|psi-mi:PRPF4(display_short)|uniprotkb:PRP4(gene name synonym) psi-mi:ppih_human(display_long)|uniprotkb:U-snRNP-associated cyclophilin SnuCyp-20(gene name synonym)|uniprotkb:Small nuclear ribonucleoprotein particle-specific cyclophilin H(gene name synonym)|uniprotkb:PPIH(gene name)|psi-mi:PPIH(display_short)|uniprotkb:CYP20(gene name synonym)|uniprotkb:CYPH(gene name synonym)|uniprotkb:Rotamase H(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514971|imex:IM-12079-45 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004688.2|refseq:NP_001231855.1|ensembl:ENSG00000136875(gene)|ensembl:ENST00000374199(transcript)|go:"GO:0000375"(RNA splicing, via transesterification reactions)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0071001"(U4/U6 snRNP)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0097525"(spliceosomal snRNP complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR014906("Pre-mRNA processing factor 4 (PRP4) like")|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|interpro:IPR015943(WD40/YVTN repeat-like)|go:"GO:0006396"(RNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0015030"(Cajal body)|go:"GO:0016607"(nuclear speck)|go:"GO:0017070"(U6 snRNA binding)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036285|interpro:IPR036322|mint:O43172|rcsb pdb:1MZW|rcsb pdb:3JCR|rcsb pdb:5O9Z|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6QW6|rcsb pdb:6QX9|reactome:R-HSA-72163|go:"GO:0030621"(U4 snRNA binding) refseq:NP_006338.1|refseq:XP_005270419.1|ensembl:ENST00000304979(transcript)|ensembl:ENST00000372550(transcript)|ensembl:ENST00000676675(transcript)|ensembl:ENST00000677900(transcript)|ensembl:ENST00000678038(transcript)|ensembl:ENST00000678333(transcript)|ensembl:ENST00000678803(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006457"(protein folding)|go:"GO:0016018"(cyclosporin A binding)|go:"GO:0016607"(nuclear speck)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071001"(U4/U6 snRNP)|interpro:IPR002130(Peptidyl-prolyl cis-trans isomerase, cyclophilin-type)|interpro:IPR020892|interpro:IPR024936|interpro:IPR029000|mint:O43447|rcsb pdb:1MZW|rcsb pdb:1QOI|rcsb pdb:5O9Z|rcsb pdb:6AHD|reactome:R-HSA-72163|ensembl:ENSG00000171960(gene)|refseq:NP_001317439.1|refseq:XP_016855546.1|refseq:XP_016855547.1|refseq:XP_016855548.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/04/15 rogid:PPTNuhEFj4D+gTv/ctTTMzGmFA09606 rogid:6gE98w/LLmT7FlCBnaBDk+GWvQU9606 intact-crc:A1F03D1DEDBF9802|rigid:zKE4/djkX/Vt9cK7sgq837rnkyY false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43172 uniprotkb:Q9Y4Z0 intact:EBI-718395|uniprotkb:O43445|uniprotkb:O43864|uniprotkb:Q96DG2|uniprotkb:Q96IK4|uniprotkb:Q5T1M8|ensembl:ENSP00000363315 intact:EBI-372521|ensembl:ENSP00000469468 psi-mi:prp4_human(display_long)|uniprotkb:U4/U6 snRNP 60 kDa protein(gene name synonym)|uniprotkb:WD splicing factor Prp4(gene name synonym)|uniprotkb:PRP4 homolog(gene name synonym)|uniprotkb:PRPF4(gene name)|psi-mi:PRPF4(display_short)|uniprotkb:PRP4(gene name synonym) psi-mi:lsm4_human(display_long)|uniprotkb:Glycine-rich protein(gene name synonym)|uniprotkb:LSM4(gene name)|psi-mi:LSM4(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514971|imex:IM-12079-45 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004688.2|refseq:NP_001231855.1|ensembl:ENSG00000136875(gene)|ensembl:ENST00000374199(transcript)|go:"GO:0000375"(RNA splicing, via transesterification reactions)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0071001"(U4/U6 snRNP)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0097525"(spliceosomal snRNP complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR014906("Pre-mRNA processing factor 4 (PRP4) like")|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|interpro:IPR015943(WD40/YVTN repeat-like)|go:"GO:0006396"(RNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0015030"(Cajal body)|go:"GO:0016607"(nuclear speck)|go:"GO:0017070"(U6 snRNA binding)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036285|interpro:IPR036322|mint:O43172|rcsb pdb:1MZW|rcsb pdb:3JCR|rcsb pdb:5O9Z|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6QW6|rcsb pdb:6QX9|reactome:R-HSA-72163|go:"GO:0030621"(U4 snRNA binding) refseq:NP_036453.1|ensembl:ENSG00000130520(gene)|ensembl:ENST00000593829(transcript)|go:"GO:0000387"(spliceosomal snRNP assembly)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000932"(P-body)|go:"GO:0000956"(nuclear-transcribed mRNA catabolic process)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005688"(U6 snRNP)|go:"GO:0005829"(cytosol)|go:"GO:0008380"(RNA splicing)|go:"GO:0016020"(membrane)|go:"GO:0017070"(U6 snRNA binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033962"(P-body assembly)|go:"GO:0042731"(PH domain binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0043005"(neuron projection)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0097526"(spliceosomal tri-snRNP complex)|go:"GO:0120115"(Lsm2-8 complex)|interpro:IPR001163(Like-Sm ribonucleoprotein, core)|interpro:IPR010920(Like-Sm ribonucleoprotein-related, core)|interpro:IPR027141|interpro:IPR034101|rcsb pdb:3JCR|rcsb pdb:5O9Z|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6QW6|rcsb pdb:6QX9|rcsb pdb:7ABG|reactome:R-HSA-430039|reactome:R-HSA-72163|dip:DIP-31209N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/04/15 rogid:PPTNuhEFj4D+gTv/ctTTMzGmFA09606 rogid:FlaQveuBbixGvfX47pCm26xscT09606 intact-crc:A1F03D1DEDBF9802|rigid:zKE4/djkX/Vt9cK7sgq837rnkyY false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43172 uniprotkb:O60925 intact:EBI-718395|uniprotkb:O43445|uniprotkb:O43864|uniprotkb:Q96DG2|uniprotkb:Q96IK4|uniprotkb:Q5T1M8|ensembl:ENSP00000363315 intact:EBI-356919|uniprotkb:Q53F95|uniprotkb:Q96EX6|uniprotkb:B2RD02|ensembl:ENSP00000261813 psi-mi:prp4_human(display_long)|uniprotkb:U4/U6 snRNP 60 kDa protein(gene name synonym)|uniprotkb:WD splicing factor Prp4(gene name synonym)|uniprotkb:PRP4 homolog(gene name synonym)|uniprotkb:PRPF4(gene name)|psi-mi:PRPF4(display_short)|uniprotkb:PRP4(gene name synonym) psi-mi:pfd1_human(display_long)|uniprotkb:PFDN1(gene name)|psi-mi:PFDN1(display_short)|uniprotkb:PFD1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514971|imex:IM-12079-45 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004688.2|refseq:NP_001231855.1|ensembl:ENSG00000136875(gene)|ensembl:ENST00000374199(transcript)|go:"GO:0000375"(RNA splicing, via transesterification reactions)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0071001"(U4/U6 snRNP)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0097525"(spliceosomal snRNP complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR014906("Pre-mRNA processing factor 4 (PRP4) like")|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|interpro:IPR015943(WD40/YVTN repeat-like)|go:"GO:0006396"(RNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0015030"(Cajal body)|go:"GO:0016607"(nuclear speck)|go:"GO:0017070"(U6 snRNA binding)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036285|interpro:IPR036322|mint:O43172|rcsb pdb:1MZW|rcsb pdb:3JCR|rcsb pdb:5O9Z|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6QW6|rcsb pdb:6QX9|reactome:R-HSA-72163|go:"GO:0030621"(U4 snRNA binding) refseq:NP_002613.2|ensembl:ENSG00000113068(gene)|ensembl:ENST00000261813(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006457"(protein folding)|go:"GO:0016272"(prefoldin complex)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0051082"(unfolded protein binding)|go:"GO:1905907"(negative regulation of amyloid fibril formation)|interpro:IPR002777(Prefoldin beta-like)|interpro:IPR009053(Prefoldin)|mint:O60925|rcsb pdb:6NR8|rcsb pdb:6NR9|rcsb pdb:6NRB|rcsb pdb:6NRC|rcsb pdb:6NRD|reactome:R-HSA-389957 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/04/15 rogid:PPTNuhEFj4D+gTv/ctTTMzGmFA09606 rogid:repqo0hQgD7XgRAZll8ucK2jwz49606 intact-crc:A1F03D1DEDBF9802|rigid:zKE4/djkX/Vt9cK7sgq837rnkyY false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43172 uniprotkb:O94906 intact:EBI-718395|uniprotkb:O43445|uniprotkb:O43864|uniprotkb:Q96DG2|uniprotkb:Q96IK4|uniprotkb:Q5T1M8|ensembl:ENSP00000363315 intact:EBI-536755|uniprotkb:O95109|uniprotkb:Q5VXS5|uniprotkb:Q9H3Z1|uniprotkb:Q9H4T9|uniprotkb:Q9H4U8|uniprotkb:Q9NTE6|ensembl:ENSP00000266079|uniprotkb:B2RAR5|uniprotkb:B3KMC6 psi-mi:prp4_human(display_long)|uniprotkb:U4/U6 snRNP 60 kDa protein(gene name synonym)|uniprotkb:WD splicing factor Prp4(gene name synonym)|uniprotkb:PRP4 homolog(gene name synonym)|uniprotkb:PRPF4(gene name)|psi-mi:PRPF4(display_short)|uniprotkb:PRP4(gene name synonym) psi-mi:prp6_human(display_long)|uniprotkb:U5 snRNP-associated 102 kDa protein(gene name synonym)|uniprotkb:PRP6 homolog(gene name synonym)|uniprotkb:PRPF6(gene name)|psi-mi:PRPF6(display_short)|uniprotkb:C20orf14(gene name synonym)|uniprotkb:Androgen receptor N-terminal domain-transactivating protein 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514971|imex:IM-12079-45 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004688.2|refseq:NP_001231855.1|ensembl:ENSG00000136875(gene)|ensembl:ENST00000374199(transcript)|go:"GO:0000375"(RNA splicing, via transesterification reactions)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0071001"(U4/U6 snRNP)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0097525"(spliceosomal snRNP complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR014906("Pre-mRNA processing factor 4 (PRP4) like")|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|interpro:IPR015943(WD40/YVTN repeat-like)|go:"GO:0006396"(RNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0015030"(Cajal body)|go:"GO:0016607"(nuclear speck)|go:"GO:0017070"(U6 snRNA binding)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036285|interpro:IPR036322|mint:O43172|rcsb pdb:1MZW|rcsb pdb:3JCR|rcsb pdb:5O9Z|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6QW6|rcsb pdb:6QX9|reactome:R-HSA-72163|go:"GO:0030621"(U4 snRNA binding) ensembl:ENSG00000101161(gene)|ensembl:ENST00000266079(transcript)|go:"GO:0000244"(spliceosomal tri-snRNP complex assembly)|go:"GO:0000375"(RNA splicing, via transesterification reactions)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0000245"(spliceosomal complex assembly)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005682"(U5 snRNP)|go:"GO:0006403"(RNA localization)|go:"GO:0008380"(RNA splicing)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0042802"(identical protein binding)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|interpro:IPR003107(RNA-processing protein, HAT helix)|interpro:IPR010491(PRP1 splicing factor, N-terminal)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR027108|mint:O94906|rcsb pdb:3JCR|rcsb pdb:5O9Z|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6QW6|rcsb pdb:6QX9|reactome:R-HSA-72163|reactome:R-HSA-72165|refseq:NP_036601.2|dip:DIP-29006N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/04/15 rogid:PPTNuhEFj4D+gTv/ctTTMzGmFA09606 rogid:M5ovIXl+1ob6VSKbXZUGU73J7Jk9606 intact-crc:A1F03D1DEDBF9802|rigid:zKE4/djkX/Vt9cK7sgq837rnkyY false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43172 uniprotkb:Q9Y333 intact:EBI-718395|uniprotkb:O43445|uniprotkb:O43864|uniprotkb:Q96DG2|uniprotkb:Q96IK4|uniprotkb:Q5T1M8|ensembl:ENSP00000363315 intact:EBI-347416|uniprotkb:Q6FGG1|ensembl:ENSP00000414006|ensembl:ENSP00000414634|ensembl:ENSP00000406280|ensembl:ENSP00000364813|ensembl:ENSP00000372883|ensembl:ENSP00000403345 psi-mi:prp4_human(display_long)|uniprotkb:U4/U6 snRNP 60 kDa protein(gene name synonym)|uniprotkb:WD splicing factor Prp4(gene name synonym)|uniprotkb:PRP4 homolog(gene name synonym)|uniprotkb:PRPF4(gene name)|psi-mi:PRPF4(display_short)|uniprotkb:PRP4(gene name synonym) psi-mi:lsm2_human(display_long)|uniprotkb:LSM2(gene name)|psi-mi:LSM2(display_short)|uniprotkb:C6orf28(gene name synonym)|uniprotkb:G7B(gene name synonym)|uniprotkb:snRNP core Sm-like protein Sm-x5(gene name synonym)|uniprotkb:Small nuclear ribonuclear protein D homolog(gene name synonym)|uniprotkb:Protein G7b(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514971|imex:IM-12079-45 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004688.2|refseq:NP_001231855.1|ensembl:ENSG00000136875(gene)|ensembl:ENST00000374199(transcript)|go:"GO:0000375"(RNA splicing, via transesterification reactions)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0071001"(U4/U6 snRNP)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0097525"(spliceosomal snRNP complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR014906("Pre-mRNA processing factor 4 (PRP4) like")|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|interpro:IPR015943(WD40/YVTN repeat-like)|go:"GO:0006396"(RNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0015030"(Cajal body)|go:"GO:0016607"(nuclear speck)|go:"GO:0017070"(U6 snRNA binding)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036285|interpro:IPR036322|mint:O43172|rcsb pdb:1MZW|rcsb pdb:3JCR|rcsb pdb:5O9Z|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6QW6|rcsb pdb:6QX9|reactome:R-HSA-72163|go:"GO:0030621"(U4 snRNA binding) refseq:NP_067000.1|ensembl:ENST00000375661(transcript)|ensembl:ENST00000383391(transcript)|ensembl:ENST00000424975(transcript)|ensembl:ENST00000432122(transcript)|ensembl:ENST00000434125(transcript)|ensembl:ENST00000455705(transcript)|go:"GO:0000244"(spliceosomal tri-snRNP complex assembly)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000932"(P-body)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005688"(U6 snRNP)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006402"(mRNA catabolic process)|go:"GO:0017070"(U6 snRNA binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071011"(precatalytic spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0120115"(Lsm2-8 complex)|go:"GO:1990726"(Lsm1-7-Pat1 complex)|interpro:IPR001163(Like-Sm ribonucleoprotein, core)|interpro:IPR010920(Like-Sm ribonucleoprotein-related, core)|interpro:IPR016654(U6 snRNA-associated Sm-like protein LSm2)|mint:Q9Y333|rcsb pdb:3JCR|rcsb pdb:5O9Z|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6QW6|rcsb pdb:6QX9|rcsb pdb:7ABG|reactome:R-HSA-430039|reactome:R-HSA-72163|reactome:R-HSA-72165|ensembl:ENSG00000172850(gene)|ensembl:ENSG00000204392(gene)|ensembl:ENSG00000224979(gene)|ensembl:ENSG00000225998(gene)|ensembl:ENSG00000231502(gene)|ensembl:ENSG00000236826(gene)|dip:DIP-31139N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/04/15 rogid:PPTNuhEFj4D+gTv/ctTTMzGmFA09606 rogid:lReyYTJxC/WlYg/ekKaqZiNNdVM9606 intact-crc:A1F03D1DEDBF9802|rigid:zKE4/djkX/Vt9cK7sgq837rnkyY false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43172 uniprotkb:Q8WWY3 intact:EBI-718395|uniprotkb:O43445|uniprotkb:O43864|uniprotkb:Q96DG2|uniprotkb:Q96IK4|uniprotkb:Q5T1M8|ensembl:ENSP00000363315 intact:EBI-1567797|uniprotkb:Q8N7F9|uniprotkb:Q9H271|uniprotkb:Q9Y439|uniprotkb:Q17RB4|intact:EBI-10177194|uniprotkb:F1T0A5|uniprotkb:E7ESA8|uniprotkb:F1T0A4|ensembl:ENSP00000324122|ensembl:ENSP00000483929 psi-mi:prp4_human(display_long)|uniprotkb:U4/U6 snRNP 60 kDa protein(gene name synonym)|uniprotkb:WD splicing factor Prp4(gene name synonym)|uniprotkb:PRP4 homolog(gene name synonym)|uniprotkb:PRPF4(gene name)|psi-mi:PRPF4(display_short)|uniprotkb:PRP4(gene name synonym) psi-mi:prp31_human(display_long)|uniprotkb:Pre-mRNA-processing factor 31(gene name synonym)|uniprotkb:U4/U6 snRNP 61 kDa protein(gene name synonym)|uniprotkb:Serologically defined breast cancer antigen NY-BR-99(gene name synonym)|uniprotkb:PRPF31(gene name)|psi-mi:PRPF31(display_short)|uniprotkb:PRP31(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514971|imex:IM-12079-45 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004688.2|refseq:NP_001231855.1|ensembl:ENSG00000136875(gene)|ensembl:ENST00000374199(transcript)|go:"GO:0000375"(RNA splicing, via transesterification reactions)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0071001"(U4/U6 snRNP)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0097525"(spliceosomal snRNP complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR014906("Pre-mRNA processing factor 4 (PRP4) like")|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|interpro:IPR015943(WD40/YVTN repeat-like)|go:"GO:0006396"(RNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0015030"(Cajal body)|go:"GO:0016607"(nuclear speck)|go:"GO:0017070"(U6 snRNA binding)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036285|interpro:IPR036322|mint:O43172|rcsb pdb:1MZW|rcsb pdb:3JCR|rcsb pdb:5O9Z|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6QW6|rcsb pdb:6QX9|reactome:R-HSA-72163|go:"GO:0030621"(U4 snRNA binding) refseq:XP_006723200.1|refseq:NP_056444.3|ensembl:ENSG00000105618(gene)|ensembl:ENSG00000275885(gene)|ensembl:ENST00000321030(transcript)|ensembl:ENST00000613693(transcript)|go:"GO:0000244"(spliceosomal tri-snRNP complex assembly)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005684"(U2-type spliceosomal complex)|go:"GO:0071339"(MLL1 complex)|go:"GO:0097526"(spliceosomal tri-snRNP complex)|go:"GO:0005687"(U4 snRNP)|go:"GO:0005690"(U4atac snRNP)|go:"GO:0015030"(Cajal body)|go:"GO:0016607"(nuclear speck)|interpro:IPR002687(Pre-mRNA processing ribonucleoprotein, binding region)|go:"GO:0030621"(U4 snRNA binding)|go:"GO:0030622"(U4atac snRNA binding)|go:"GO:0042802"(identical protein binding)|interpro:IPR012976(NOSIC)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0070990"(snRNP binding)|interpro:IPR019175|interpro:IPR027105|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071011"(precatalytic spliceosome)|go:"GO:0071166"(ribonucleoprotein complex localization)|interpro:IPR036070|interpro:IPR042239|mint:Q8WWY3|rcsb pdb:2OZB|rcsb pdb:3JCR|rcsb pdb:3SIU|rcsb pdb:3SIV|rcsb pdb:5O9Z|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6QW6|rcsb pdb:6QX9|reactome:R-HSA-72163 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/04/15 rogid:PPTNuhEFj4D+gTv/ctTTMzGmFA09606 rogid:NsXY3tY7Y2EEK8rxoisqlfpzuf89606 intact-crc:A1F03D1DEDBF9802|rigid:zKE4/djkX/Vt9cK7sgq837rnkyY false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43172 uniprotkb:Q92802 intact:EBI-718395|uniprotkb:O43445|uniprotkb:O43864|uniprotkb:Q96DG2|uniprotkb:Q96IK4|uniprotkb:Q5T1M8|ensembl:ENSP00000363315 intact:EBI-2514973|uniprotkb:A3KME8|ensembl:ENSP00000267068|ensembl:ENSP00000501416|ensembl:ENSP00000501516|ensembl:ENSP00000501518|ensembl:ENSP00000501537 psi-mi:prp4_human(display_long)|uniprotkb:U4/U6 snRNP 60 kDa protein(gene name synonym)|uniprotkb:WD splicing factor Prp4(gene name synonym)|uniprotkb:PRP4 homolog(gene name synonym)|uniprotkb:PRPF4(gene name)|psi-mi:PRPF4(display_short)|uniprotkb:PRP4(gene name synonym) psi-mi:n42l2_human(display_long)|uniprotkb:N4BP2L2(gene name)|psi-mi:N4BP2L2(display_short)|uniprotkb:CG005(gene name synonym)|uniprotkb:PFAAP5(gene name synonym)|uniprotkb:Phosphonoformate immuno-associated protein 5(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514971|imex:IM-12079-45 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004688.2|refseq:NP_001231855.1|ensembl:ENSG00000136875(gene)|ensembl:ENST00000374199(transcript)|go:"GO:0000375"(RNA splicing, via transesterification reactions)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0071001"(U4/U6 snRNP)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0097525"(spliceosomal snRNP complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR014906("Pre-mRNA processing factor 4 (PRP4) like")|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|interpro:IPR015943(WD40/YVTN repeat-like)|go:"GO:0006396"(RNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0015030"(Cajal body)|go:"GO:0016607"(nuclear speck)|go:"GO:0017070"(U6 snRNA binding)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036285|interpro:IPR036322|mint:O43172|rcsb pdb:1MZW|rcsb pdb:3JCR|rcsb pdb:5O9Z|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6QW6|rcsb pdb:6QX9|reactome:R-HSA-72163|go:"GO:0030621"(U4 snRNA binding) refseq:XP_016875836.1|refseq:XP_016875837.1|refseq:XP_016875838.1|refseq:NP_055702.1|ensembl:ENSG00000244754(gene)|ensembl:ENST00000267068(transcript)|ensembl:ENST00000674349(transcript)|ensembl:ENST00000674421(transcript)|ensembl:ENST00000674465(transcript)|ensembl:ENST00000674484(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001824"(blastocyst development)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019899"(enzyme binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1902035"(positive regulation of hematopoietic stem cell proliferation)|go:"GO:1902037"(negative regulation of hematopoietic stem cell differentiation)|interpro:IPR026302|interpro:IPR026568|interpro:IPR027417|mint:Q92802 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/04/15 rogid:PPTNuhEFj4D+gTv/ctTTMzGmFA09606 rogid:a7wRNCzoB/ImcDT7U8E5355qX1A9606 intact-crc:A1F03D1DEDBF9802|rigid:zKE4/djkX/Vt9cK7sgq837rnkyY false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43172 uniprotkb:P61758 intact:EBI-718395|uniprotkb:O43445|uniprotkb:O43864|uniprotkb:Q96DG2|uniprotkb:Q96IK4|uniprotkb:Q5T1M8|ensembl:ENSP00000363315 intact:EBI-357430|ensembl:ENSP00000286428|uniprotkb:Q15765|uniprotkb:O55228|uniprotkb:Q5JT81|uniprotkb:Q86X96|uniprotkb:B2R8L5|uniprotkb:B4DWR3|uniprotkb:F5H2A7 psi-mi:prp4_human(display_long)|uniprotkb:U4/U6 snRNP 60 kDa protein(gene name synonym)|uniprotkb:WD splicing factor Prp4(gene name synonym)|uniprotkb:PRP4 homolog(gene name synonym)|uniprotkb:PRPF4(gene name)|psi-mi:PRPF4(display_short)|uniprotkb:PRP4(gene name synonym) psi-mi:pfd3_human(display_long)|uniprotkb:VBP1(gene name)|psi-mi:VBP1(display_short)|uniprotkb:PFDN3(gene name synonym)|uniprotkb:von Hippel-Lindau-binding protein 1(gene name synonym)|uniprotkb:HIBBJ46(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514971|imex:IM-12079-45 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004688.2|refseq:NP_001231855.1|ensembl:ENSG00000136875(gene)|ensembl:ENST00000374199(transcript)|go:"GO:0000375"(RNA splicing, via transesterification reactions)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0071001"(U4/U6 snRNP)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0097525"(spliceosomal snRNP complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR014906("Pre-mRNA processing factor 4 (PRP4) like")|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|interpro:IPR015943(WD40/YVTN repeat-like)|go:"GO:0006396"(RNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0015030"(Cajal body)|go:"GO:0016607"(nuclear speck)|go:"GO:0017070"(U6 snRNA binding)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036285|interpro:IPR036322|mint:O43172|rcsb pdb:1MZW|rcsb pdb:3JCR|rcsb pdb:5O9Z|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6QW6|rcsb pdb:6QX9|reactome:R-HSA-72163|go:"GO:0030621"(U4 snRNA binding) ensembl:ENSG00000155959(gene)|ensembl:ENST00000286428(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006457"(protein folding)|go:"GO:0007017"(microtubule-based process)|go:"GO:0007021"(tubulin complex assembly)|go:"GO:0015631"(tubulin binding)|go:"GO:0016272"(prefoldin complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0051082"(unfolded protein binding)|go:"GO:1905907"(negative regulation of amyloid fibril formation)|interpro:IPR004127(Prefoldin alpha-like)|interpro:IPR009053(Prefoldin)|interpro:IPR016655(Prefoldin, subunit 3)|mint:P61758|rcsb pdb:6NR8|rcsb pdb:6NR9|rcsb pdb:6NRB|rcsb pdb:6NRC|rcsb pdb:6NRD|reactome:R-HSA-389957|refseq:NP_003363.1|refseq:NP_001290472.1|refseq:NP_001290474.1|dip:DIP-46479N|refseq:NP_001290473.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/04/15 rogid:PPTNuhEFj4D+gTv/ctTTMzGmFA09606 rogid:wHq+HRvhqfKwOaKtONGJdfETQxo9606 intact-crc:A1F03D1DEDBF9802|rigid:zKE4/djkX/Vt9cK7sgq837rnkyY false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43172 uniprotkb:O43395 intact:EBI-718395|uniprotkb:O43445|uniprotkb:O43864|uniprotkb:Q96DG2|uniprotkb:Q96IK4|uniprotkb:Q5T1M8|ensembl:ENSP00000363315 intact:EBI-744322|uniprotkb:O43446|uniprotkb:Q5VT54|uniprotkb:B4DSY9|intact:EBI-28983618|ensembl:ENSP00000315379 psi-mi:prp4_human(display_long)|uniprotkb:U4/U6 snRNP 60 kDa protein(gene name synonym)|uniprotkb:WD splicing factor Prp4(gene name synonym)|uniprotkb:PRP4 homolog(gene name synonym)|uniprotkb:PRPF4(gene name)|psi-mi:PRPF4(display_short)|uniprotkb:PRP4(gene name synonym) psi-mi:prpf3_human(display_long)|uniprotkb:Pre-mRNA-splicing factor 3(gene name synonym)|uniprotkb:U4/U6 snRNP 90 kDa protein(gene name synonym)|uniprotkb:PRPF3(gene name)|psi-mi:PRPF3(display_short)|uniprotkb:HPRP3(gene name synonym)|uniprotkb:PRP3(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514971|imex:IM-12079-45 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004688.2|refseq:NP_001231855.1|ensembl:ENSG00000136875(gene)|ensembl:ENST00000374199(transcript)|go:"GO:0000375"(RNA splicing, via transesterification reactions)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0071001"(U4/U6 snRNP)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0097525"(spliceosomal snRNP complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR014906("Pre-mRNA processing factor 4 (PRP4) like")|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|interpro:IPR015943(WD40/YVTN repeat-like)|go:"GO:0006396"(RNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0015030"(Cajal body)|go:"GO:0016607"(nuclear speck)|go:"GO:0017070"(U6 snRNA binding)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036285|interpro:IPR036322|mint:O43172|rcsb pdb:1MZW|rcsb pdb:3JCR|rcsb pdb:5O9Z|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6QW6|rcsb pdb:6QX9|reactome:R-HSA-72163|go:"GO:0030621"(U4 snRNA binding) refseq:NP_004689.1|ensembl:ENSP00000315379|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005829"(cytosol)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0015030"(Cajal body)|go:"GO:0016607"(nuclear speck)|go:"GO:0042802"(identical protein binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0071005"(U2-type precatalytic spliceosome)|interpro:IPR002483(Splicing factor PWI)|interpro:IPR010541(Protein of unknown function DUF1115)|interpro:IPR013881(Pre-mRNA-splicing factor 3)|interpro:IPR027104|interpro:IPR036483|mint:O43395|rcsb pdb:1X4Q|rcsb pdb:3JCR|rcsb pdb:5O9Z|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6QW6|rcsb pdb:6QX9|reactome:R-HSA-72163|ensembl:ENSG00000117360(gene)|ensembl:ENST00000324862(transcript)|go:"GO:0000244"(spliceosomal tri-snRNP complex assembly)|go:"GO:0000375"(RNA splicing, via transesterification reactions)|dip:DIP-34508N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/04/15 rogid:PPTNuhEFj4D+gTv/ctTTMzGmFA09606 rogid:Y2aO1gQjTU8JERVtrLpgbXq7nLU9606 intact-crc:A1F03D1DEDBF9802|rigid:zKE4/djkX/Vt9cK7sgq837rnkyY false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43172 uniprotkb:Q9BTD8 intact:EBI-718395|uniprotkb:O43445|uniprotkb:O43864|uniprotkb:Q96DG2|uniprotkb:Q96IK4|uniprotkb:Q5T1M8|ensembl:ENSP00000363315 intact:EBI-746862|uniprotkb:O00320|uniprotkb:Q8N5R7|uniprotkb:Q9BU66|ensembl:ENSP00000262633 psi-mi:prp4_human(display_long)|uniprotkb:U4/U6 snRNP 60 kDa protein(gene name synonym)|uniprotkb:WD splicing factor Prp4(gene name synonym)|uniprotkb:PRP4 homolog(gene name synonym)|uniprotkb:PRPF4(gene name)|psi-mi:PRPF4(display_short)|uniprotkb:PRP4(gene name synonym) psi-mi:rbm42_human(display_long)|uniprotkb:RNA-binding motif protein 42(gene name synonym)|uniprotkb:RBM42(gene name)|psi-mi:RBM42(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514971|imex:IM-12079-45 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004688.2|refseq:NP_001231855.1|ensembl:ENSG00000136875(gene)|ensembl:ENST00000374199(transcript)|go:"GO:0000375"(RNA splicing, via transesterification reactions)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0071001"(U4/U6 snRNP)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0097525"(spliceosomal snRNP complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR014906("Pre-mRNA processing factor 4 (PRP4) like")|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|interpro:IPR015943(WD40/YVTN repeat-like)|go:"GO:0006396"(RNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0015030"(Cajal body)|go:"GO:0016607"(nuclear speck)|go:"GO:0017070"(U6 snRNA binding)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036285|interpro:IPR036322|mint:O43172|rcsb pdb:1MZW|rcsb pdb:3JCR|rcsb pdb:5O9Z|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6QW6|rcsb pdb:6QX9|reactome:R-HSA-72163|go:"GO:0030621"(U4 snRNA binding) refseq:NP_001306042.1|refseq:NP_077297.2|ensembl:ENSG00000126254(gene)|ensembl:ENST00000262633(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0048025"(negative regulation of mRNA splicing, via spliceosome)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034215|interpro:IPR035979|rcsb pdb:6QW6|rcsb pdb:6QX9|go:"GO:0003723"(RNA binding) psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/04/15 rogid:PPTNuhEFj4D+gTv/ctTTMzGmFA09606 rogid:lZboYvefRzyEBdGJKGGrWJEyV0g9606 intact-crc:A1F03D1DEDBF9802|rigid:zKE4/djkX/Vt9cK7sgq837rnkyY false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43172 uniprotkb:Q9UGL1 intact:EBI-718395|uniprotkb:O43445|uniprotkb:O43864|uniprotkb:Q96DG2|uniprotkb:Q96IK4|uniprotkb:Q5T1M8|ensembl:ENSP00000363315 intact:EBI-2514978|uniprotkb:Q9Y3Q5|uniprotkb:O95811|uniprotkb:Q15752|ensembl:ENSP00000356234 psi-mi:prp4_human(display_long)|uniprotkb:U4/U6 snRNP 60 kDa protein(gene name synonym)|uniprotkb:WD splicing factor Prp4(gene name synonym)|uniprotkb:PRP4 homolog(gene name synonym)|uniprotkb:PRPF4(gene name)|psi-mi:PRPF4(display_short)|uniprotkb:PRP4(gene name synonym) psi-mi:kdm5b_human(display_long)|uniprotkb:KDM5B(gene name)|psi-mi:KDM5B(display_short)|uniprotkb:JARID1B(gene name synonym)|uniprotkb:PLU1(gene name synonym)|uniprotkb:RBBP2H1(gene name synonym)|uniprotkb:Histone demethylase JARID1B(gene name synonym)|uniprotkb:Jumonji/ARID domain-containing protein 1B(gene name synonym)|uniprotkb:PLU-1(gene name synonym)|uniprotkb:Retinoblastoma-binding protein 2 homolog 1(gene name synonym)|uniprotkb:Cancer/testis antigen 31(gene name synonym)|uniprotkb:"[histone H3]-trimethyl-L-lysine(4) demethylase 5B"(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514971|imex:IM-12079-45 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004688.2|refseq:NP_001231855.1|ensembl:ENSG00000136875(gene)|ensembl:ENST00000374199(transcript)|go:"GO:0000375"(RNA splicing, via transesterification reactions)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0071001"(U4/U6 snRNP)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0097525"(spliceosomal snRNP complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR014906("Pre-mRNA processing factor 4 (PRP4) like")|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|interpro:IPR015943(WD40/YVTN repeat-like)|go:"GO:0006396"(RNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0015030"(Cajal body)|go:"GO:0016607"(nuclear speck)|go:"GO:0017070"(U6 snRNA binding)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036285|interpro:IPR036322|mint:O43172|rcsb pdb:1MZW|rcsb pdb:3JCR|rcsb pdb:5O9Z|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6QW6|rcsb pdb:6QX9|reactome:R-HSA-72163|go:"GO:0030621"(U4 snRNA binding) refseq:NP_001300971.1|refseq:NP_006609.3|dip:DIP-53652N|ensembl:ENSG00000117139(gene)|ensembl:ENST00000367265(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0007338"(single fertilization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0032452"(histone demethylase activity)|go:"GO:0032453"(histone H3-methyl-lysine-4 demethylase activity)|go:"GO:0033601"(positive regulation of mammary gland epithelial cell proliferation)|go:"GO:0034647"(histone H3-tri/di/monomethyl-lysine-4 demethylase activity)|go:"GO:0034648"("obsolete histone demethylase activity (H3-dimethyl-K4 specific)")|go:"GO:0034720"(histone H3-K4 demethylation)|go:"GO:0042393"(histone binding)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048511"(rhythmic process)|go:"GO:0051213"(dioxygenase activity)|go:"GO:0060444"(branching involved in mammary gland duct morphogenesis)|go:"GO:0060763"(mammary duct terminal end bud growth)|go:"GO:0060992"(response to fungicide)|go:"GO:0061038"(uterus morphogenesis)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000864"(regulation of estradiol secretion)|interpro:IPR001606(AT-rich interaction region)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR003347(Transcription factor jumonji/aspartyl beta-hydroxylase)|interpro:IPR003349(Transcription factor jumonji, JmjN)|interpro:IPR004198(Zinc finger, C5HC2-type)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013637(PLU-1-like)|interpro:IPR019786|interpro:IPR019787|interpro:IPR036431|mint:Q9UGL1|rcsb pdb:2MA5|rcsb pdb:2MNY|rcsb pdb:2MNZ|rcsb pdb:5A1F|rcsb pdb:5A3N|rcsb pdb:5A3P|rcsb pdb:5A3T|rcsb pdb:5A3W|rcsb pdb:5FPL|rcsb pdb:5FPU|rcsb pdb:5FUN|rcsb pdb:5FUP|rcsb pdb:5FV3|rcsb pdb:5FY4|rcsb pdb:5FY5|rcsb pdb:5FY9|rcsb pdb:5FYB|rcsb pdb:5FYS|rcsb pdb:5FYT|rcsb pdb:5FYU|rcsb pdb:5FYV|rcsb pdb:5FYY|rcsb pdb:5FYZ|rcsb pdb:5FZ0|rcsb pdb:5FZ1|rcsb pdb:5FZ3|rcsb pdb:5FZ4|rcsb pdb:5FZ6|rcsb pdb:5FZ7|rcsb pdb:5FZ8|rcsb pdb:5FZ9|rcsb pdb:5FZA|rcsb pdb:5FZB|rcsb pdb:5FZC|rcsb pdb:5FZD|rcsb pdb:5FZE|rcsb pdb:5FZF|rcsb pdb:5FZG|rcsb pdb:5FZH|rcsb pdb:5FZI|rcsb pdb:5FZK|rcsb pdb:5FZL|rcsb pdb:5FZM|go:"GO:0070306"(lens fiber cell differentiation)|rcsb pdb:5LW9|rcsb pdb:5LWB|rcsb pdb:6EIN|rcsb pdb:6EIU|rcsb pdb:6EIY|rcsb pdb:6EJ0|rcsb pdb:6EJ1|rcsb pdb:6EK6|rcsb pdb:6H4Z|rcsb pdb:6H50|rcsb pdb:6H51|rcsb pdb:6H52|rcsb pdb:6RBI|reactome:R-HSA-3214842|reactome:R-HSA-8866911 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/04/15 rogid:PPTNuhEFj4D+gTv/ctTTMzGmFA09606 rogid:HXNXUmikf5+ywMuA4UStrabarzM9606 intact-crc:A1F03D1DEDBF9802|rigid:zKE4/djkX/Vt9cK7sgq837rnkyY false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43172 uniprotkb:O95777 intact:EBI-718395|uniprotkb:O43445|uniprotkb:O43864|uniprotkb:Q96DG2|uniprotkb:Q96IK4|uniprotkb:Q5T1M8|ensembl:ENSP00000363315 intact:EBI-347779|ensembl:ENSP00000249299 psi-mi:prp4_human(display_long)|uniprotkb:U4/U6 snRNP 60 kDa protein(gene name synonym)|uniprotkb:WD splicing factor Prp4(gene name synonym)|uniprotkb:PRP4 homolog(gene name synonym)|uniprotkb:PRPF4(gene name)|psi-mi:PRPF4(display_short)|uniprotkb:PRP4(gene name synonym) psi-mi:lsm8_human(display_long)|uniprotkb:LSM8(gene name)|psi-mi:LSM8(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514971|imex:IM-12079-45 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004688.2|refseq:NP_001231855.1|ensembl:ENSG00000136875(gene)|ensembl:ENST00000374199(transcript)|go:"GO:0000375"(RNA splicing, via transesterification reactions)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0071001"(U4/U6 snRNP)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0097525"(spliceosomal snRNP complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR014906("Pre-mRNA processing factor 4 (PRP4) like")|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|interpro:IPR015943(WD40/YVTN repeat-like)|go:"GO:0006396"(RNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0015030"(Cajal body)|go:"GO:0016607"(nuclear speck)|go:"GO:0017070"(U6 snRNA binding)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036285|interpro:IPR036322|mint:O43172|rcsb pdb:1MZW|rcsb pdb:3JCR|rcsb pdb:5O9Z|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6QW6|rcsb pdb:6QX9|reactome:R-HSA-72163|go:"GO:0030621"(U4 snRNA binding) refseq:NP_057284.1|dip:DIP-31195N|ensembl:ENSG00000128534(gene)|ensembl:ENST00000249299(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005688"(U6 snRNP)|go:"GO:0016070"(RNA metabolic process)|go:"GO:0017070"(U6 snRNA binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071011"(precatalytic spliceosome)|go:"GO:0120115"(Lsm2-8 complex)|interpro:IPR001163(Like-Sm ribonucleoprotein, core)|interpro:IPR010920(Like-Sm ribonucleoprotein-related, core)|interpro:IPR034103|interpro:IPR044642|rcsb pdb:3JCR|rcsb pdb:5O9Z|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6QW6|rcsb pdb:6QX9|rcsb pdb:7ABG|reactome:R-HSA-72163 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/04/15 rogid:PPTNuhEFj4D+gTv/ctTTMzGmFA09606 rogid:Kyf8IAEIkbe1s2NnqxqGA1o6BbU9606 intact-crc:A1F03D1DEDBF9802|rigid:zKE4/djkX/Vt9cK7sgq837rnkyY false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43172 uniprotkb:Q9H6E5 intact:EBI-718395|uniprotkb:O43445|uniprotkb:O43864|uniprotkb:Q96DG2|uniprotkb:Q96IK4|uniprotkb:Q5T1M8|ensembl:ENSP00000363315 intact:EBI-2511680|ensembl:ENSP00000419607|uniprotkb:Q9H6H7|uniprotkb:Q7L583|uniprotkb:Q2NL65|uniprotkb:A1A527|intact:EBI-2809257|uniprotkb:A8K995 psi-mi:prp4_human(display_long)|uniprotkb:U4/U6 snRNP 60 kDa protein(gene name synonym)|uniprotkb:WD splicing factor Prp4(gene name synonym)|uniprotkb:PRP4 homolog(gene name synonym)|uniprotkb:PRPF4(gene name)|psi-mi:PRPF4(display_short)|uniprotkb:PRP4(gene name synonym) psi-mi:stpap_human(display_long)|uniprotkb:TUT1(gene name)|psi-mi:TUT1(display_short)|uniprotkb:RBM21(gene name synonym)|uniprotkb:RNA-binding motif protein 21(gene name synonym)|uniprotkb:U6 snRNA-specific terminal uridylyltransferase 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514971|imex:IM-12079-45 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004688.2|refseq:NP_001231855.1|ensembl:ENSG00000136875(gene)|ensembl:ENST00000374199(transcript)|go:"GO:0000375"(RNA splicing, via transesterification reactions)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0071001"(U4/U6 snRNP)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0097525"(spliceosomal snRNP complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR014906("Pre-mRNA processing factor 4 (PRP4) like")|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|interpro:IPR015943(WD40/YVTN repeat-like)|go:"GO:0006396"(RNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0015030"(Cajal body)|go:"GO:0016607"(nuclear speck)|go:"GO:0017070"(U6 snRNA binding)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036285|interpro:IPR036322|mint:O43172|rcsb pdb:1MZW|rcsb pdb:3JCR|rcsb pdb:5O9Z|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6QW6|rcsb pdb:6QX9|reactome:R-HSA-72163|go:"GO:0030621"(U4 snRNA binding) rcsb pdb:5WU6|rcsb pdb:5WU5|ensembl:ENSG00000149016(gene)|ensembl:ENST00000476907(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0004652"(polynucleotide adenylyltransferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006378"(mRNA polyadenylation)|go:"GO:0016180"(snRNA processing)|go:"GO:0016607"(nuclear speck)|go:"GO:0016779"(nucleotidyltransferase activity)|go:"GO:0017070"(U6 snRNA binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0031123"(RNA 3'-end processing)|go:"GO:0034477"(U6 snRNA 3'-end processing)|go:"GO:0046872"(metal ion binding)|go:"GO:0050265"(RNA uridylyltransferase activity)|go:"GO:0098789"(pre-mRNA cleavage required for polyadenylation)|go:"GO:1990817"(RNA adenylyltransferase activity)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR002058(PAP/25A-associated)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034388|interpro:IPR035979|interpro:IPR036236|interpro:IPR043519|mint:Q9H6E5|rcsb pdb:2E5G|rcsb pdb:5WU1|rcsb pdb:5WU2|rcsb pdb:5WU3|rcsb pdb:5WU4|go:"GO:0005730"(nucleolus)|refseq:NP_073741.2|dip:DIP-53651N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/04/15 rogid:PPTNuhEFj4D+gTv/ctTTMzGmFA09606 rogid:7Df5H4dyiKBTRo4xiRZGbzGvzbk9606 intact-crc:A1F03D1DEDBF9802|rigid:zKE4/djkX/Vt9cK7sgq837rnkyY false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43172 uniprotkb:P62312 intact:EBI-718395|uniprotkb:O43445|uniprotkb:O43864|uniprotkb:Q96DG2|uniprotkb:Q96IK4|uniprotkb:Q5T1M8|ensembl:ENSP00000363315 intact:EBI-373310|uniprotkb:Q9Y4Y8|uniprotkb:Q4W5J5|ensembl:ENSP00000296581|ensembl:ENSP00000420929|ensembl:ENSP00000422392|ensembl:ENSP00000427036|ensembl:ENSP00000497311 psi-mi:prp4_human(display_long)|uniprotkb:U4/U6 snRNP 60 kDa protein(gene name synonym)|uniprotkb:WD splicing factor Prp4(gene name synonym)|uniprotkb:PRP4 homolog(gene name synonym)|uniprotkb:PRPF4(gene name)|psi-mi:PRPF4(display_short)|uniprotkb:PRP4(gene name synonym) psi-mi:lsm6_human(display_long)|uniprotkb:LSM6(gene name)|psi-mi:LSM6(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514971|imex:IM-12079-45 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004688.2|refseq:NP_001231855.1|ensembl:ENSG00000136875(gene)|ensembl:ENST00000374199(transcript)|go:"GO:0000375"(RNA splicing, via transesterification reactions)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0071001"(U4/U6 snRNP)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0097525"(spliceosomal snRNP complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR014906("Pre-mRNA processing factor 4 (PRP4) like")|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|interpro:IPR015943(WD40/YVTN repeat-like)|go:"GO:0006396"(RNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0015030"(Cajal body)|go:"GO:0016607"(nuclear speck)|go:"GO:0017070"(U6 snRNA binding)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036285|interpro:IPR036322|mint:O43172|rcsb pdb:1MZW|rcsb pdb:3JCR|rcsb pdb:5O9Z|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6QW6|rcsb pdb:6QX9|reactome:R-HSA-72163|go:"GO:0030621"(U4 snRNA binding) refseq:NP_009011.1|ensembl:ENSG00000164167(gene)|ensembl:ENST00000296581(transcript)|ensembl:ENST00000502781(transcript)|ensembl:ENST00000504181(transcript)|ensembl:ENST00000515311(transcript)|ensembl:ENST00000649747(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000932"(P-body)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005688"(U6 snRNP)|go:"GO:0005730"(nucleolus)|go:"GO:0005732"("sno(s)RNA-containing ribonucleoprotein complex")|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006402"(mRNA catabolic process)|go:"GO:0008033"(tRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0030490"(maturation of SSU-rRNA)|go:"GO:0030532"(small nuclear ribonucleoprotein complex)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0120115"(Lsm2-8 complex)|interpro:IPR001163(Like-Sm ribonucleoprotein, core)|interpro:IPR010920(Like-Sm ribonucleoprotein-related, core)|interpro:IPR016487(Small nuclear ribonucleoprotein SmF)|mint:P62312|rcsb pdb:3JCR|rcsb pdb:5O9Z|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6QW6|rcsb pdb:6QX9|rcsb pdb:7ABG|reactome:R-HSA-430039|reactome:R-HSA-72163|refseq:XP_016863161.1|refseq:XP_016863162.1|dip:DIP-31128N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/04/15 rogid:PPTNuhEFj4D+gTv/ctTTMzGmFA09606 rogid:knWeW+soIyeLSg0Xbe79er748hE9606 intact-crc:A1F03D1DEDBF9802|rigid:zKE4/djkX/Vt9cK7sgq837rnkyY false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43172 uniprotkb:Q8WVK2 intact:EBI-718395|uniprotkb:O43445|uniprotkb:O43864|uniprotkb:Q96DG2|uniprotkb:Q96IK4|uniprotkb:Q5T1M8|ensembl:ENSP00000363315 intact:EBI-2512550|ensembl:ENSP00000244227|ensembl:ENSP00000395144|uniprotkb:Q15410|intact:EBI-2557655 psi-mi:prp4_human(display_long)|uniprotkb:U4/U6 snRNP 60 kDa protein(gene name synonym)|uniprotkb:WD splicing factor Prp4(gene name synonym)|uniprotkb:PRP4 homolog(gene name synonym)|uniprotkb:PRPF4(gene name)|psi-mi:PRPF4(display_short)|uniprotkb:PRP4(gene name synonym) psi-mi:snr27_human(display_long)|uniprotkb:SNRNP27(gene name)|psi-mi:SNRNP27(display_short)|uniprotkb:U4/U6.U5 tri-snRNP-associated protein 3(gene name synonym)|uniprotkb:U4/U6.U5 tri-snRNP-associated 27 kDa protein(gene name synonym)|uniprotkb:Nucleic acid-binding protein RY-1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514971|imex:IM-12079-45 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004688.2|refseq:NP_001231855.1|ensembl:ENSG00000136875(gene)|ensembl:ENST00000374199(transcript)|go:"GO:0000375"(RNA splicing, via transesterification reactions)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0071001"(U4/U6 snRNP)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0097525"(spliceosomal snRNP complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR014906("Pre-mRNA processing factor 4 (PRP4) like")|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|interpro:IPR015943(WD40/YVTN repeat-like)|go:"GO:0006396"(RNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0015030"(Cajal body)|go:"GO:0016607"(nuclear speck)|go:"GO:0017070"(U6 snRNA binding)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036285|interpro:IPR036322|mint:O43172|rcsb pdb:1MZW|rcsb pdb:3JCR|rcsb pdb:5O9Z|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6QW6|rcsb pdb:6QX9|reactome:R-HSA-72163|go:"GO:0030621"(U4 snRNA binding) ensembl:ENSG00000124380(gene)|ensembl:ENST00000244227(transcript)|ensembl:ENST00000450162(transcript)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|interpro:IPR013957(Protein of unknown function DUF1777)|rcsb pdb:6QW6|rcsb pdb:6QX9|reactome:R-HSA-72163|refseq:NP_006848.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/04/15 rogid:PPTNuhEFj4D+gTv/ctTTMzGmFA09606 rogid:wSOfld20fuDA9ZN9vDXLilFmmSs9606 intact-crc:A1F03D1DEDBF9802|rigid:zKE4/djkX/Vt9cK7sgq837rnkyY false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43172 uniprotkb:O43290 intact:EBI-718395|uniprotkb:O43445|uniprotkb:O43864|uniprotkb:Q96DG2|uniprotkb:Q96IK4|uniprotkb:Q5T1M8|ensembl:ENSP00000363315 intact:EBI-607761|ensembl:ENSP00000310448|uniprotkb:A6NDN1|uniprotkb:Q53GB5 psi-mi:prp4_human(display_long)|uniprotkb:U4/U6 snRNP 60 kDa protein(gene name synonym)|uniprotkb:WD splicing factor Prp4(gene name synonym)|uniprotkb:PRP4 homolog(gene name synonym)|uniprotkb:PRPF4(gene name)|psi-mi:PRPF4(display_short)|uniprotkb:PRP4(gene name synonym) psi-mi:snut1_human(display_long)|uniprotkb:U4/U6.U5 tri-snRNP-associated 110 kDa protein(gene name synonym)|uniprotkb:SART1(gene name)|psi-mi:SART1(display_short)|uniprotkb:SNU66 homolog(gene name synonym)|uniprotkb:Squamous cell carcinoma antigen recognized by T-cells 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514971|imex:IM-12079-45 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004688.2|refseq:NP_001231855.1|ensembl:ENSG00000136875(gene)|ensembl:ENST00000374199(transcript)|go:"GO:0000375"(RNA splicing, via transesterification reactions)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0071001"(U4/U6 snRNP)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0097525"(spliceosomal snRNP complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR014906("Pre-mRNA processing factor 4 (PRP4) like")|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|interpro:IPR015943(WD40/YVTN repeat-like)|go:"GO:0006396"(RNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0015030"(Cajal body)|go:"GO:0016607"(nuclear speck)|go:"GO:0017070"(U6 snRNA binding)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036285|interpro:IPR036322|mint:O43172|rcsb pdb:1MZW|rcsb pdb:3JCR|rcsb pdb:5O9Z|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6QW6|rcsb pdb:6QX9|reactome:R-HSA-72163|go:"GO:0030621"(U4 snRNA binding) ensembl:ENSG00000175467(gene)|ensembl:ENST00000312397(transcript)|go:"GO:0000387"(spliceosomal snRNP assembly)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000481"(maturation of 5S rRNA)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0015030"(Cajal body)|go:"GO:0016607"(nuclear speck)|go:"GO:0045292"(mRNA cis splicing, via spliceosome)|go:"GO:0045585"(positive regulation of cytotoxic T cell differentiation)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|interpro:IPR005011(SART-1 protein)|mint:O43290|rcsb pdb:4PYU|rcsb pdb:5O9Z|rcsb pdb:6AHD|rcsb pdb:6QW6|rcsb pdb:6QX9|reactome:R-HSA-72163|refseq:NP_005137.1|dip:DIP-33360N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/04/15 rogid:PPTNuhEFj4D+gTv/ctTTMzGmFA09606 rogid:egvWHy7UXW+MkGtGEW984yvRU9k9606 intact-crc:A1F03D1DEDBF9802|rigid:zKE4/djkX/Vt9cK7sgq837rnkyY false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43172 uniprotkb:O15212 intact:EBI-718395|uniprotkb:O43445|uniprotkb:O43864|uniprotkb:Q96DG2|uniprotkb:Q96IK4|uniprotkb:Q5T1M8|ensembl:ENSP00000363315 intact:EBI-356973|ensembl:ENSP00000363734|ensembl:ENSP00000363735|ensembl:ENSP00000363738|ensembl:ENSP00000372694|ensembl:ENSP00000378563|ensembl:ENSP00000382314|ensembl:ENSP00000382316|ensembl:ENSP00000395462|ensembl:ENSP00000398171|ensembl:ENSP00000400152|ensembl:ENSP00000402212|ensembl:ENSP00000402553|ensembl:ENSP00000403771|ensembl:ENSP00000404773|ensembl:ENSP00000412319|ensembl:ENSP00000415678|ensembl:ENSP00000447540|ensembl:ENSP00000448607|ensembl:ENSP00000448784|ensembl:ENSP00000449925 psi-mi:prp4_human(display_long)|uniprotkb:U4/U6 snRNP 60 kDa protein(gene name synonym)|uniprotkb:WD splicing factor Prp4(gene name synonym)|uniprotkb:PRP4 homolog(gene name synonym)|uniprotkb:PRPF4(gene name)|psi-mi:PRPF4(display_short)|uniprotkb:PRP4(gene name synonym) psi-mi:pfd6_human(display_long)|uniprotkb:PFDN6(gene name)|psi-mi:PFDN6(display_short)|uniprotkb:HKE2(gene name synonym)|uniprotkb:PFD6(gene name synonym)|uniprotkb:Protein Ke2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514971|imex:IM-12079-45 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004688.2|refseq:NP_001231855.1|ensembl:ENSG00000136875(gene)|ensembl:ENST00000374199(transcript)|go:"GO:0000375"(RNA splicing, via transesterification reactions)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0071001"(U4/U6 snRNP)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0097525"(spliceosomal snRNP complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR014906("Pre-mRNA processing factor 4 (PRP4) like")|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|interpro:IPR015943(WD40/YVTN repeat-like)|go:"GO:0006396"(RNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0015030"(Cajal body)|go:"GO:0016607"(nuclear speck)|go:"GO:0017070"(U6 snRNA binding)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036285|interpro:IPR036322|mint:O43172|rcsb pdb:1MZW|rcsb pdb:3JCR|rcsb pdb:5O9Z|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6QW6|rcsb pdb:6QX9|reactome:R-HSA-72163|go:"GO:0030621"(U4 snRNA binding) refseq:NP_001172110.1|refseq:NP_055075.1|refseq:NP_001252524.1|refseq:NP_001252525.1|dip:DIP-50304N|ensembl:ENSG00000204220(gene)|ensembl:ENSG00000206283(gene)|ensembl:ENSG00000224782(gene)|ensembl:ENSG00000235692(gene)|ensembl:ENSG00000237335(gene)|ensembl:ENST00000374606(transcript)|ensembl:ENST00000374607(transcript)|ensembl:ENST00000374610(transcript)|ensembl:ENST00000383207(transcript)|ensembl:ENST00000395131(transcript)|ensembl:ENST00000399383(transcript)|ensembl:ENST00000399385(transcript)|ensembl:ENST00000412289(transcript)|ensembl:ENST00000425878(transcript)|ensembl:ENST00000431830(transcript)|ensembl:ENST00000432391(transcript)|ensembl:ENST00000442285(transcript)|ensembl:ENST00000445559(transcript)|ensembl:ENST00000448594(transcript)|ensembl:ENST00000451970(transcript)|ensembl:ENST00000452658(transcript)|ensembl:ENST00000547641(transcript)|ensembl:ENST00000547952(transcript)|ensembl:ENST00000548040(transcript)|ensembl:ENST00000552711(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006457"(protein folding)|go:"GO:0016272"(prefoldin complex)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:1905907"(negative regulation of amyloid fibril formation)|interpro:IPR002777(Prefoldin beta-like)|interpro:IPR009053(Prefoldin)|mint:O15212|rcsb pdb:6NR8|rcsb pdb:6NR9|rcsb pdb:6NRB|rcsb pdb:6NRC|rcsb pdb:6NRD|reactome:R-HSA-389957 psi-mi:"MI:0469"(intact) - crc64:8F138EAAE512A312 figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/04/15 rogid:PPTNuhEFj4D+gTv/ctTTMzGmFA09606 rogid:t7Z68vuvmprxLIGDh4JhqCGvX+A9606 intact-crc:A1F03D1DEDBF9802|rigid:zKE4/djkX/Vt9cK7sgq837rnkyY false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43172 uniprotkb:Q9NQX3 intact:EBI-718395|uniprotkb:O43445|uniprotkb:O43864|uniprotkb:Q96DG2|uniprotkb:Q96IK4|uniprotkb:Q5T1M8|ensembl:ENSP00000363315 intact:EBI-2371891|uniprotkb:Q9H4E9|uniprotkb:Q9P2G2|uniprotkb:Q96KU4|ensembl:ENSP00000312771 psi-mi:prp4_human(display_long)|uniprotkb:U4/U6 snRNP 60 kDa protein(gene name synonym)|uniprotkb:WD splicing factor Prp4(gene name synonym)|uniprotkb:PRP4 homolog(gene name synonym)|uniprotkb:PRPF4(gene name)|psi-mi:PRPF4(display_short)|uniprotkb:PRP4(gene name synonym) psi-mi:geph_human(display_long)|uniprotkb:GPHN(gene name)|psi-mi:GPHN(display_short)|uniprotkb:GPH(gene name synonym)|uniprotkb:KIAA1385(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514971|imex:IM-12079-45 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004688.2|refseq:NP_001231855.1|ensembl:ENSG00000136875(gene)|ensembl:ENST00000374199(transcript)|go:"GO:0000375"(RNA splicing, via transesterification reactions)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0071001"(U4/U6 snRNP)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0097525"(spliceosomal snRNP complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR014906("Pre-mRNA processing factor 4 (PRP4) like")|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|interpro:IPR015943(WD40/YVTN repeat-like)|go:"GO:0006396"(RNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0015030"(Cajal body)|go:"GO:0016607"(nuclear speck)|go:"GO:0017070"(U6 snRNA binding)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036285|interpro:IPR036322|mint:O43172|rcsb pdb:1MZW|rcsb pdb:3JCR|rcsb pdb:5O9Z|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6QW6|rcsb pdb:6QX9|reactome:R-HSA-72163|go:"GO:0030621"(U4 snRNA binding) refseq:NP_001019389.1|refseq:NP_065857.1|dip:DIP-41076N|rcsb pdb:1JLJ|reactome:R-HSA-947581|interpro:IPR038987|ensembl:ENSG00000171723(gene)|ensembl:ENST00000315266(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006777"(Mo-molybdopterin cofactor biosynthetic process)|go:"GO:0007529"(establishment of synaptic specificity at neuromuscular junction)|go:"GO:0008940"(nitrate reductase activity)|go:"GO:0010038"(response to metal ion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0018315"(molybdenum incorporation into molybdenum-molybdopterin complex)|go:"GO:0030425"(dendrite)|go:"GO:0032324"(molybdopterin cofactor biosynthetic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043546"(molybdopterin cofactor binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0061598"(molybdopterin adenylyltransferase activity)|go:"GO:0061599"(molybdopterin molybdotransferase activity)|go:"GO:0072579"(glycine receptor clustering)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097112"(gamma-aminobutyric acid receptor clustering)|go:"GO:0098970"(postsynaptic neurotransmitter receptor diffusion trapping)|go:"GO:0099144"(anchored component of synaptic membrane)|go:"GO:0099572"(postsynaptic specialization)|go:"GO:0099634"(postsynaptic specialization membrane)|interpro:IPR001453(Molybdopterin binding)|interpro:IPR005110(MoeA, N-terminal, domain I and II)|interpro:IPR005111(MoeA, C-terminal, domain IV)|interpro:IPR008284(Molybdenum cofactor biosynthesis, conserved site)|interpro:IPR036135|interpro:IPR036425|interpro:IPR036688 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/04/15 rogid:PPTNuhEFj4D+gTv/ctTTMzGmFA09606 rogid:iu4Nl7g9dOChbmYok/lo6kjW3pM9606 intact-crc:A1F03D1DEDBF9802|rigid:zKE4/djkX/Vt9cK7sgq837rnkyY false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43172 uniprotkb:Q9UK45 intact:EBI-718395|uniprotkb:O43445|uniprotkb:O43864|uniprotkb:Q96DG2|uniprotkb:Q96IK4|uniprotkb:Q5T1M8|ensembl:ENSP00000363315 intact:EBI-348372|ensembl:ENSP00000252622 psi-mi:prp4_human(display_long)|uniprotkb:U4/U6 snRNP 60 kDa protein(gene name synonym)|uniprotkb:WD splicing factor Prp4(gene name synonym)|uniprotkb:PRP4 homolog(gene name synonym)|uniprotkb:PRPF4(gene name)|psi-mi:PRPF4(display_short)|uniprotkb:PRP4(gene name synonym) psi-mi:lsm7_human(display_long)|uniprotkb:LSM7(gene name)|psi-mi:LSM7(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514971|imex:IM-12079-45 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004688.2|refseq:NP_001231855.1|ensembl:ENSG00000136875(gene)|ensembl:ENST00000374199(transcript)|go:"GO:0000375"(RNA splicing, via transesterification reactions)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0071001"(U4/U6 snRNP)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0097525"(spliceosomal snRNP complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR014906("Pre-mRNA processing factor 4 (PRP4) like")|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|interpro:IPR015943(WD40/YVTN repeat-like)|go:"GO:0006396"(RNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0015030"(Cajal body)|go:"GO:0016607"(nuclear speck)|go:"GO:0017070"(U6 snRNA binding)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036285|interpro:IPR036322|mint:O43172|rcsb pdb:1MZW|rcsb pdb:3JCR|rcsb pdb:5O9Z|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6QW6|rcsb pdb:6QX9|reactome:R-HSA-72163|go:"GO:0030621"(U4 snRNA binding) refseq:NP_057283.1|interpro:IPR017132(U6 snRNA-associated Sm-like protein LSm7)|interpro:IPR044641|rcsb pdb:3JCR|rcsb pdb:5O9Z|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6QW6|rcsb pdb:6QX9|rcsb pdb:7ABG|reactome:R-HSA-430039|reactome:R-HSA-72163|go:"GO:0005689"(U12-type spliceosomal complex)|go:"GO:0005829"(cytosol)|go:"GO:0017070"(U6 snRNA binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0071004"(U2-type prespliceosome)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0097526"(spliceosomal tri-snRNP complex)|go:"GO:0120115"(Lsm2-8 complex)|go:"GO:1990726"(Lsm1-7-Pat1 complex)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR001163(Like-Sm ribonucleoprotein, core)|interpro:IPR010920(Like-Sm ribonucleoprotein-related, core)|ensembl:ENSG00000130332(gene)|ensembl:ENST00000252622(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000956"(nuclear-transcribed mRNA catabolic process)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005688"(U6 snRNP)|dip:DIP-31129N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/04/15 rogid:PPTNuhEFj4D+gTv/ctTTMzGmFA09606 rogid:vT1gI3yzYl37cX++CUGdJowAL909606 intact-crc:A1F03D1DEDBF9802|rigid:zKE4/djkX/Vt9cK7sgq837rnkyY false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:O43172 uniprotkb:Q53GS9 intact:EBI-718395|uniprotkb:O43445|uniprotkb:O43864|uniprotkb:Q96DG2|uniprotkb:Q96IK4|uniprotkb:Q5T1M8|ensembl:ENSP00000363315 intact:EBI-1044822|uniprotkb:Q6NX47|uniprotkb:Q96RK9|uniprotkb:Q9BV89|uniprotkb:Q9H381|uniprotkb:Q9P050|uniprotkb:Q9Y310|uniprotkb:A8K086|ensembl:ENSP00000312981|ensembl:ENSP00000386864|uniprotkb:D6W5L4|intact:EBI-2557627|uniprotkb:B4DHT4|uniprotkb:B3KM40|uniprotkb:G5E9H0 psi-mi:prp4_human(display_long)|uniprotkb:U4/U6 snRNP 60 kDa protein(gene name synonym)|uniprotkb:WD splicing factor Prp4(gene name synonym)|uniprotkb:PRP4 homolog(gene name synonym)|uniprotkb:PRPF4(gene name)|psi-mi:PRPF4(display_short)|uniprotkb:PRP4(gene name synonym) psi-mi:snut2_human(display_long)|uniprotkb:U4/U6.U5 tri-snRNP-associated 65 kDa protein(gene name synonym)|uniprotkb:Inactive ubiquitin-specific peptidase 39(gene name synonym)|uniprotkb:SAD1 homolog(gene name synonym)|uniprotkb:USP39(gene name)|psi-mi:USP39(display_short)|uniprotkb:CGI-21(orf name)|uniprotkb:HSPC332(orf name)|uniprotkb:PRO2855(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2514971|imex:IM-12079-45 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004688.2|refseq:NP_001231855.1|ensembl:ENSG00000136875(gene)|ensembl:ENST00000374199(transcript)|go:"GO:0000375"(RNA splicing, via transesterification reactions)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0071001"(U4/U6 snRNP)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0097525"(spliceosomal snRNP complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR014906("Pre-mRNA processing factor 4 (PRP4) like")|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|interpro:IPR015943(WD40/YVTN repeat-like)|go:"GO:0006396"(RNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0015030"(Cajal body)|go:"GO:0016607"(nuclear speck)|go:"GO:0017070"(U6 snRNA binding)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036285|interpro:IPR036322|mint:O43172|rcsb pdb:1MZW|rcsb pdb:3JCR|rcsb pdb:5O9Z|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6QW6|rcsb pdb:6QX9|reactome:R-HSA-72163|go:"GO:0030621"(U4 snRNA binding) refseq:NP_006581.2|go:"GO:0008270"(zinc ion binding)|go:"GO:0008380"(RNA splicing)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0051301"(cell division)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR001607(Zinc finger, UBP-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR028889|interpro:IPR033809|interpro:IPR038765|go:"GO:0007049"(cell cycle)|rcsb pdb:3JCR|rcsb pdb:6AH0|rcsb pdb:6QW6|rcsb pdb:6QX9|reactome:R-HSA-72163|ensembl:ENSG00000168883(gene)|ensembl:ENST00000323701(transcript)|ensembl:ENST00000409470(transcript)|go:"GO:0000245"(spliceosomal complex assembly)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0006397"(mRNA processing)|refseq:NP_001243656.1|refseq:NP_001243657.1|refseq:NP_001243654.1|refseq:NP_001243655.1|refseq:XP_006711985.1|refseq:XP_006711986.1|refseq:XP_011530789.1|refseq:XP_011530790.1|refseq:XP_016858671.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/04/15 rogid:PPTNuhEFj4D+gTv/ctTTMzGmFA09606 rogid:AMLhskNenuv+zqXSa7VesSbbVK89606 intact-crc:A1F03D1DEDBF9802|rigid:zKE4/djkX/Vt9cK7sgq837rnkyY false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P24386 uniprotkb:Q9UNN5 intact:EBI-2515129|ensembl:ENSP00000350386|uniprotkb:O43732|uniprotkb:A1L4D2 intact:EBI-718246|uniprotkb:Q9UF34|uniprotkb:Q9UNT3|uniprotkb:Q9Y2Z3|uniprotkb:Q549F0|ensembl:ENSP00000379457 psi-mi:rae1_human(display_long)|uniprotkb:CHM(gene name)|psi-mi:CHM(display_short)|uniprotkb:REP1(gene name synonym)|uniprotkb:TCD(gene name synonym)|uniprotkb:Rab escort protein 1(gene name synonym)|uniprotkb:TCD protein(gene name synonym)|uniprotkb:Choroideremia protein(gene name synonym) psi-mi:faf1_human(display_long)|uniprotkb:FAF1(gene name)|psi-mi:FAF1(display_short)|uniprotkb:CGI-03(orf name)|uniprotkb:UBXD12(gene name synonym)|uniprotkb:UBXN3A(gene name synonym)|uniprotkb:UBX domain-containing protein 3A(gene name synonym)|uniprotkb:UBX domain-containing protein 12(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515120|imex:IM-12079-96 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000188419(gene)|ensembl:ENST00000357749(transcript)|go:"GO:0004663"(Rab geranylgeranyltransferase activity)|go:"GO:0005092"(GDP-dissociation inhibitor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005968"(Rab-protein geranylgeranyltransferase complex)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0007601"(visual perception)|go:"GO:0018344"(protein geranylgeranylation)|go:"GO:0031267"(small GTPase binding)|interpro:IPR001738("Rab escort (choroideraemia) protein")|interpro:IPR018203|interpro:IPR036188|reactome:R-HSA-6803205|reactome:R-HSA-8873719|reactome:R-HSA-8876198|go:"GO:0016192"(vesicle-mediated transport)|refseq:NP_001307888.1|refseq:NP_000381.1|refseq:NP_001138886.1 refseq:NP_008982.1|ensembl:ENSP00000379457|ensembl:ENSG00000185104(gene)|ensembl:ENST00000396153(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007253"(cytoplasmic sequestering of NF-kappaB)|go:"GO:0008219"(cell death)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0031265"(CD95 death-inducing signaling complex)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034098"(VCP-NPL4-UFD1 AAA ATPase complex)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1903364"(positive regulation of cellular protein catabolic process)|interpro:IPR001012(UBX)|interpro:IPR006577(UAS)|interpro:IPR029071|interpro:IPR033043|interpro:IPR036249|interpro:IPR044541|rcsb pdb:1H8C|rcsb pdb:2DZM|rcsb pdb:2EC4|rcsb pdb:3E21|rcsb pdb:3QC8|rcsb pdb:3QCA|rcsb pdb:3QQ8|rcsb pdb:3QWZ|rcsb pdb:3QX1|rcsb pdb:3R3M|go:"GO:0031072"(heat shock protein binding)|dip:DIP-38245N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/07/08 rogid:lLHJ/D4ljKMp+kSHMHu9RUTdcps9606 rogid:jYlrz7+swvye+qZ/6F4yTv74wLI9606 intact-crc:02E62AA95A194E51|rigid:OZZTjyWFxESXZbq4Dy5CU5tDT8c false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P24386 uniprotkb:Q96S15 intact:EBI-2515129|ensembl:ENSP00000350386|uniprotkb:O43732|uniprotkb:A1L4D2 intact:EBI-746424|uniprotkb:Q96GC7|uniprotkb:Q9H0B7|uniprotkb:A2IDB8|uniprotkb:D3DU59|ensembl:ENSP00000293883|intact:EBI-11086802 psi-mi:rae1_human(display_long)|uniprotkb:CHM(gene name)|psi-mi:CHM(display_short)|uniprotkb:REP1(gene name synonym)|uniprotkb:TCD(gene name synonym)|uniprotkb:Rab escort protein 1(gene name synonym)|uniprotkb:TCD protein(gene name synonym)|uniprotkb:Choroideremia protein(gene name synonym) psi-mi:wdr24_human(display_long)|uniprotkb:WDR24(gene name)|psi-mi:WDR24(display_short)|uniprotkb:C16orf21(gene name synonym)|uniprotkb:WD repeat-containing protein 24(gene name synonym)|uniprotkb:JFP7(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515120|imex:IM-12079-96 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000188419(gene)|ensembl:ENST00000357749(transcript)|go:"GO:0004663"(Rab geranylgeranyltransferase activity)|go:"GO:0005092"(GDP-dissociation inhibitor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005968"(Rab-protein geranylgeranyltransferase complex)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0007601"(visual perception)|go:"GO:0018344"(protein geranylgeranylation)|go:"GO:0031267"(small GTPase binding)|interpro:IPR001738("Rab escort (choroideraemia) protein")|interpro:IPR018203|interpro:IPR036188|reactome:R-HSA-6803205|reactome:R-HSA-8873719|reactome:R-HSA-8876198|go:"GO:0016192"(vesicle-mediated transport)|refseq:NP_001307888.1|refseq:NP_000381.1|refseq:NP_001138886.1 refseq:NP_115635.1|ensembl:ENSG00000127580(gene)|ensembl:ENST00000293883(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0061700"(GATOR2 complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR036322|interpro:IPR037590|reactome:R-HSA-9639288|dip:DIP-53812N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/07/08 rogid:lLHJ/D4ljKMp+kSHMHu9RUTdcps9606 rogid:t4jmiY8uryt3X3y5QUGYRMGFpXg9606 intact-crc:02E62AA95A194E51|rigid:OZZTjyWFxESXZbq4Dy5CU5tDT8c false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P24386 uniprotkb:Q14181 intact:EBI-2515129|ensembl:ENSP00000350386|uniprotkb:O43732|uniprotkb:A1L4D2 intact:EBI-712752|ensembl:ENSP00000265465|uniprotkb:Q9BPV3|uniprotkb:B4DNB4 psi-mi:rae1_human(display_long)|uniprotkb:CHM(gene name)|psi-mi:CHM(display_short)|uniprotkb:REP1(gene name synonym)|uniprotkb:TCD(gene name synonym)|uniprotkb:Rab escort protein 1(gene name synonym)|uniprotkb:TCD protein(gene name synonym)|uniprotkb:Choroideremia protein(gene name synonym) psi-mi:dpoa2_human(display_long)|uniprotkb:DNA polymerase alpha 70 kDa subunit(gene name synonym)|uniprotkb:POLA2(gene name)|psi-mi:POLA2(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515120|imex:IM-12079-96 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000188419(gene)|ensembl:ENST00000357749(transcript)|go:"GO:0004663"(Rab geranylgeranyltransferase activity)|go:"GO:0005092"(GDP-dissociation inhibitor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005968"(Rab-protein geranylgeranyltransferase complex)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0007601"(visual perception)|go:"GO:0018344"(protein geranylgeranylation)|go:"GO:0031267"(small GTPase binding)|interpro:IPR001738("Rab escort (choroideraemia) protein")|interpro:IPR018203|interpro:IPR036188|reactome:R-HSA-6803205|reactome:R-HSA-8873719|reactome:R-HSA-8876198|go:"GO:0016192"(vesicle-mediated transport)|refseq:NP_001307888.1|refseq:NP_000381.1|refseq:NP_001138886.1 reactome:R-HSA-69183|reactome:R-HSA-69166|reactome:R-HSA-9710421|ensembl:ENSG00000014138(gene)|ensembl:ENST00000265465(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005658"("alpha DNA polymerase:primase complex")|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006269"(DNA replication, synthesis of RNA primer)|go:"GO:0006270"(DNA replication initiation)|interpro:IPR007185(DNA polymerase alpha/epsilon, subunit B)|interpro:IPR013627(DNA polymerase alpha, subunit B N-terminal)|interpro:IPR016722(DNA polymerase alpha, subunit B)|interpro:IPR043034|rcsb pdb:2KEB|rcsb pdb:4E2I|rcsb pdb:4Y97|rcsb pdb:5EXR|reactome:R-HSA-113501|reactome:R-HSA-174411|reactome:R-HSA-174430|reactome:R-HSA-68952|reactome:R-HSA-68962|reactome:R-HSA-69091|refseq:NP_002680.2 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/07/08 rogid:lLHJ/D4ljKMp+kSHMHu9RUTdcps9606 rogid:cPvK8qerkbSbnl1+TAIlBqTuEFU9606 intact-crc:02E62AA95A194E51|rigid:OZZTjyWFxESXZbq4Dy5CU5tDT8c false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P24386 uniprotkb:Q92890 intact:EBI-2515129|ensembl:ENSP00000350386|uniprotkb:O43732|uniprotkb:A1L4D2 intact:EBI-1994090|uniprotkb:Q9Y5N0|uniprotkb:A8MW31|ensembl:ENSP00000263202 psi-mi:rae1_human(display_long)|uniprotkb:CHM(gene name)|psi-mi:CHM(display_short)|uniprotkb:REP1(gene name synonym)|uniprotkb:TCD(gene name synonym)|uniprotkb:Rab escort protein 1(gene name synonym)|uniprotkb:TCD protein(gene name synonym)|uniprotkb:Choroideremia protein(gene name synonym) psi-mi:ufd1_human(display_long)|uniprotkb:UFD1(gene name)|psi-mi:UFD1(display_short)|uniprotkb:UFD1L(gene name synonym)|uniprotkb:Ubiquitin fusion degradation protein 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515120|imex:IM-12079-96 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000188419(gene)|ensembl:ENST00000357749(transcript)|go:"GO:0004663"(Rab geranylgeranyltransferase activity)|go:"GO:0005092"(GDP-dissociation inhibitor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005968"(Rab-protein geranylgeranyltransferase complex)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0007601"(visual perception)|go:"GO:0018344"(protein geranylgeranylation)|go:"GO:0031267"(small GTPase binding)|interpro:IPR001738("Rab escort (choroideraemia) protein")|interpro:IPR018203|interpro:IPR036188|reactome:R-HSA-6803205|reactome:R-HSA-8873719|reactome:R-HSA-8876198|go:"GO:0016192"(vesicle-mediated transport)|refseq:NP_001307888.1|refseq:NP_000381.1|refseq:NP_001138886.1 refseq:NP_005650.2|refseq:NP_001030324.2|dip:DIP-45954N|ensembl:ENSG00000070010(gene)|ensembl:ENST00000263202(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0032480"(negative regulation of type I interferon production)|go:"GO:0034098"(VCP-NPL4-UFD1 AAA ATPase complex)|go:"GO:0036435"(K48-linked polyubiquitin modification-dependent protein binding)|go:"GO:0036501"(UFD1-NPL4 complex)|go:"GO:0039536"(negative regulation of RIG-I signaling pathway)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0071712"(ER-associated misfolded protein catabolic process)|interpro:IPR004854(Ubiquitin fusion degradation protein UFD1)|interpro:IPR042299|mint:Q92890|rcsb pdb:2YUJ|rcsb pdb:5B6C|rcsb pdb:5C1B|reactome:R-HSA-110320|reactome:R-HSA-5689880|go:"GO:0031593"(polyubiquitin modification-dependent protein binding) psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/07/08 rogid:lLHJ/D4ljKMp+kSHMHu9RUTdcps9606 rogid:TD7xj2n1cP5JexKMoVg1JfTQArI9606 intact-crc:02E62AA95A194E51|rigid:OZZTjyWFxESXZbq4Dy5CU5tDT8c false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P24386 uniprotkb:Q96JG8 intact:EBI-2515129|ensembl:ENSP00000350386|uniprotkb:O43732|uniprotkb:A1L4D2 intact:EBI-721864|uniprotkb:Q8WXW4|uniprotkb:Q9BQ84|uniprotkb:Q9BYH3|uniprotkb:Q9BYH4|uniprotkb:A8K093|uniprotkb:Q5HYN6|uniprotkb:Q9BVH1|uniprotkb:Q9H217|ensembl:ENSP00000335385|ensembl:ENSP00000423848|ensembl:ENSP00000507908 psi-mi:rae1_human(display_long)|uniprotkb:CHM(gene name)|psi-mi:CHM(display_short)|uniprotkb:REP1(gene name synonym)|uniprotkb:TCD(gene name synonym)|uniprotkb:Rab escort protein 1(gene name synonym)|uniprotkb:TCD protein(gene name synonym)|uniprotkb:Choroideremia protein(gene name synonym) psi-mi:magd4_human(display_long)|uniprotkb:MAGED4B(gene name)|psi-mi:MAGED4B(display_short)|uniprotkb:MAGED4A(gene name synonym)|uniprotkb:MAGE-D4 antigen(gene name synonym)|uniprotkb:MAGE-E1 antigen(gene name synonym)|uniprotkb:MAGED4(gene name)|psi-mi:MAGED4(display_short)|uniprotkb:KIAA1859(gene name synonym)|uniprotkb:MAGEE1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515120|imex:IM-12079-96 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000188419(gene)|ensembl:ENST00000357749(transcript)|go:"GO:0004663"(Rab geranylgeranyltransferase activity)|go:"GO:0005092"(GDP-dissociation inhibitor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005968"(Rab-protein geranylgeranyltransferase complex)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0007601"(visual perception)|go:"GO:0018344"(protein geranylgeranylation)|go:"GO:0031267"(small GTPase binding)|interpro:IPR001738("Rab escort (choroideraemia) protein")|interpro:IPR018203|interpro:IPR036188|reactome:R-HSA-6803205|reactome:R-HSA-8873719|reactome:R-HSA-8876198|go:"GO:0016192"(vesicle-mediated transport)|refseq:NP_001307888.1|refseq:NP_000381.1|refseq:NP_001138886.1 refseq:NP_001092270.1|refseq:NP_001229291.1|refseq:NP_110428.2|refseq:NP_803879.1|refseq:NP_803881.1|refseq:XP_011529124.1|refseq:NP_001258990.1|refseq:NP_001258991.1|refseq:NP_001258992.1|refseq:XP_006724670.1|refseq:XP_006724671.1|refseq:XP_016885365.1|ensembl:ENSG00000154545(gene)|ensembl:ENSG00000187243(gene)|ensembl:ENST00000335504(transcript)|ensembl:ENST00000471932(transcript)|interpro:IPR002190(MAGE protein)|interpro:IPR030091|interpro:IPR037445|interpro:IPR041898|interpro:IPR041899|ensembl:ENST00000497164(transcript) psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/07/08 rogid:lLHJ/D4ljKMp+kSHMHu9RUTdcps9606 rogid:xmAofBgVdNieZVQMV9ag6Pq++DA9606 intact-crc:02E62AA95A194E51|rigid:OZZTjyWFxESXZbq4Dy5CU5tDT8c false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P24386 uniprotkb:Q9BZL6 intact:EBI-2515129|ensembl:ENSP00000350386|uniprotkb:O43732|uniprotkb:A1L4D2 intact:EBI-1384325|uniprotkb:Q8TB08|uniprotkb:Q9P0T6|uniprotkb:Q9Y3X8|uniprotkb:M0R2R2|uniprotkb:Q8NCK8|uniprotkb:B4DTS2|uniprotkb:M0QZW1|ensembl:ENSP00000291281|ensembl:ENSP00000393978 psi-mi:rae1_human(display_long)|uniprotkb:CHM(gene name)|psi-mi:CHM(display_short)|uniprotkb:REP1(gene name synonym)|uniprotkb:TCD(gene name synonym)|uniprotkb:Rab escort protein 1(gene name synonym)|uniprotkb:TCD protein(gene name synonym)|uniprotkb:Choroideremia protein(gene name synonym) psi-mi:kpcd2_human(display_long)|uniprotkb:PKD2(gene name synonym)|uniprotkb:nPKC-D2(gene name synonym)|uniprotkb:HSPC187(orf name)|uniprotkb:PRKD2(gene name)|psi-mi:PRKD2(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515120|imex:IM-12079-96 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000188419(gene)|ensembl:ENST00000357749(transcript)|go:"GO:0004663"(Rab geranylgeranyltransferase activity)|go:"GO:0005092"(GDP-dissociation inhibitor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005968"(Rab-protein geranylgeranyltransferase complex)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0007601"(visual perception)|go:"GO:0018344"(protein geranylgeranylation)|go:"GO:0031267"(small GTPase binding)|interpro:IPR001738("Rab escort (choroideraemia) protein")|interpro:IPR018203|interpro:IPR036188|reactome:R-HSA-6803205|reactome:R-HSA-8873719|reactome:R-HSA-8876198|go:"GO:0016192"(vesicle-mediated transport)|refseq:NP_001307888.1|refseq:NP_000381.1|refseq:NP_001138886.1 refseq:NP_001073349.1|refseq:NP_001073350.1|refseq:NP_001073351.1|refseq:NP_057541.2|refseq:XP_005258773.2|ensembl:ENSG00000105287(gene)|ensembl:ENST00000291281(transcript)|ensembl:ENST00000433867(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004697"(protein kinase C activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007155"(cell adhesion)|go:"GO:0008219"(cell death)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030148"(sphingolipid biosynthetic process)|go:"GO:0030949"(positive regulation of vascular endothelial growth factor receptor signaling pathway)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032793"(positive regulation of CREB transcription factor activity)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0038033"(positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045743"(positive regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0061154"(endothelial tube morphogenesis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0089700"(protein kinase D signaling)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901727"(positive regulation of histone deacetylase activity)|go:"GO:1902533"(positive regulation of intracellular signal transduction)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|go:"GO:2001028"(positive regulation of endothelial cell chemotaxis)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR015727(Protein kinase C mu-related)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q9BZL6|rcsb pdb:2COA|rcsb pdb:3BGM|rcsb pdb:4NNX|rcsb pdb:4NNY|reactome:R-HSA-1660661|interpro:IPR020454 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/07/08 rogid:lLHJ/D4ljKMp+kSHMHu9RUTdcps9606 rogid:Sy4Lim5BpD4r3h7+1hknKP1o4OQ9606 intact-crc:02E62AA95A194E51|rigid:OZZTjyWFxESXZbq4Dy5CU5tDT8c false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P24386 uniprotkb:Q12874 intact:EBI-2515129|ensembl:ENSP00000350386|uniprotkb:O43732|uniprotkb:A1L4D2 intact:EBI-1051880|uniprotkb:Q15460|uniprotkb:Q5VT87|uniprotkb:D3DPT5|ensembl:ENSP00000362110 psi-mi:rae1_human(display_long)|uniprotkb:CHM(gene name)|psi-mi:CHM(display_short)|uniprotkb:REP1(gene name synonym)|uniprotkb:TCD(gene name synonym)|uniprotkb:Rab escort protein 1(gene name synonym)|uniprotkb:TCD protein(gene name synonym)|uniprotkb:Choroideremia protein(gene name synonym) psi-mi:sf3a3_human(display_long)|uniprotkb:Spliceosome-associated protein 61(gene name synonym)|uniprotkb:SF3a60(gene name synonym)|uniprotkb:SF3A3(gene name)|psi-mi:SF3A3(display_short)|uniprotkb:SAP61(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515120|imex:IM-12079-96 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000188419(gene)|ensembl:ENST00000357749(transcript)|go:"GO:0004663"(Rab geranylgeranyltransferase activity)|go:"GO:0005092"(GDP-dissociation inhibitor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005968"(Rab-protein geranylgeranyltransferase complex)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0007601"(visual perception)|go:"GO:0018344"(protein geranylgeranylation)|go:"GO:0031267"(small GTPase binding)|interpro:IPR001738("Rab escort (choroideraemia) protein")|interpro:IPR018203|interpro:IPR036188|reactome:R-HSA-6803205|reactome:R-HSA-8873719|reactome:R-HSA-8876198|go:"GO:0016192"(vesicle-mediated transport)|refseq:NP_001307888.1|refseq:NP_000381.1|refseq:NP_001138886.1 refseq:NP_006793.1|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005686"(U2 snRNP)|go:"GO:0006397"(mRNA processing)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016607"(nuclear speck)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:1903241"(U2-type prespliceosome assembly)|interpro:IPR000690(Zinc finger, C2H2-type matrin)|interpro:IPR021966|interpro:IPR024598|interpro:IPR031774|interpro:IPR031776|mint:Q12874|rcsb pdb:2DT7|rcsb pdb:5Z56|rcsb pdb:5Z57|rcsb pdb:5Z58|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6FF7|go:"GO:0000389"(mRNA 3'-splice site recognition)|rcsb pdb:6QX9|rcsb pdb:6Y50|rcsb pdb:6Y5Q|rcsb pdb:7ABG|rcsb pdb:7ABH|rcsb pdb:7ABI|reactome:R-HSA-72163|rcsb pdb:6Y53|ensembl:ENSG00000183431(gene)|ensembl:ENST00000373019(transcript)|go:"GO:0000375"(RNA splicing, via transesterification reactions)|dip:DIP-882N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/07/08 rogid:lLHJ/D4ljKMp+kSHMHu9RUTdcps9606 rogid:fNjNguUOXqApr46rOAEpTs2geqY9606 intact-crc:02E62AA95A194E51|rigid:OZZTjyWFxESXZbq4Dy5CU5tDT8c false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P24386 uniprotkb:O75390 intact:EBI-2515129|ensembl:ENSP00000350386|uniprotkb:O43732|uniprotkb:A1L4D2 intact:EBI-487493|ensembl:ENSP00000342056|uniprotkb:Q71UT9|uniprotkb:Q7KZH0|uniprotkb:Q96FZ8|uniprotkb:Q9BWN8 psi-mi:rae1_human(display_long)|uniprotkb:CHM(gene name)|psi-mi:CHM(display_short)|uniprotkb:REP1(gene name synonym)|uniprotkb:TCD(gene name synonym)|uniprotkb:Rab escort protein 1(gene name synonym)|uniprotkb:TCD protein(gene name synonym)|uniprotkb:Choroideremia protein(gene name synonym) psi-mi:cisy_human(display_long)|uniprotkb:CS(gene name)|psi-mi:CS(display_short)|uniprotkb:"Citrate (Si)-synthase"(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515120|imex:IM-12079-96 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000188419(gene)|ensembl:ENST00000357749(transcript)|go:"GO:0004663"(Rab geranylgeranyltransferase activity)|go:"GO:0005092"(GDP-dissociation inhibitor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005968"(Rab-protein geranylgeranyltransferase complex)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0007601"(visual perception)|go:"GO:0018344"(protein geranylgeranylation)|go:"GO:0031267"(small GTPase binding)|interpro:IPR001738("Rab escort (choroideraemia) protein")|interpro:IPR018203|interpro:IPR036188|reactome:R-HSA-6803205|reactome:R-HSA-8873719|reactome:R-HSA-8876198|go:"GO:0016192"(vesicle-mediated transport)|refseq:NP_001307888.1|refseq:NP_000381.1|refseq:NP_001138886.1 go:"GO:0006101"(citrate metabolic process)|refseq:NP_004068.2|ensembl:ENSG00000062485(gene)|go:"GO:0004108"("citrate (Si)-synthase activity")|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0003723"(RNA binding)|ensembl:ENST00000351328(transcript)|rcsb pdb:5UZQ|rcsb pdb:5UZR|reactome:R-HSA-1268020|reactome:R-HSA-71403|go:"GO:0070062"(extracellular exosome)|interpro:IPR002020(Citrate synthase-like)|interpro:IPR010109(Citrate synthase, eukaryotic)|interpro:IPR016142(Citrate synthase-like, large alpha subdomain)|interpro:IPR016143(Citrate synthase-like, small alpha subdomain)|interpro:IPR019810|interpro:IPR036969|rcsb pdb:5UZP psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/07/08 rogid:lLHJ/D4ljKMp+kSHMHu9RUTdcps9606 rogid:XKpnEsGOlGRNIAXMk4tTBH2okzo9606 intact-crc:02E62AA95A194E51|rigid:OZZTjyWFxESXZbq4Dy5CU5tDT8c false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P24386 uniprotkb:Q99627 intact:EBI-2515129|ensembl:ENSP00000350386|uniprotkb:O43732|uniprotkb:A1L4D2 intact:EBI-2510102|ensembl:ENSP00000346340|uniprotkb:A8K1H6|uniprotkb:Q53QS9 psi-mi:rae1_human(display_long)|uniprotkb:CHM(gene name)|psi-mi:CHM(display_short)|uniprotkb:REP1(gene name synonym)|uniprotkb:TCD(gene name synonym)|uniprotkb:Rab escort protein 1(gene name synonym)|uniprotkb:TCD protein(gene name synonym)|uniprotkb:Choroideremia protein(gene name synonym) psi-mi:csn8_human(display_long)|uniprotkb:COPS8(gene name)|psi-mi:COPS8(display_short)|uniprotkb:CSN8(gene name synonym)|uniprotkb:JAB1-containing signalosome subunit 8(gene name synonym)|uniprotkb:COP9 homolog(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515120|imex:IM-12079-96 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000188419(gene)|ensembl:ENST00000357749(transcript)|go:"GO:0004663"(Rab geranylgeranyltransferase activity)|go:"GO:0005092"(GDP-dissociation inhibitor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005968"(Rab-protein geranylgeranyltransferase complex)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0007601"(visual perception)|go:"GO:0018344"(protein geranylgeranylation)|go:"GO:0031267"(small GTPase binding)|interpro:IPR001738("Rab escort (choroideraemia) protein")|interpro:IPR018203|interpro:IPR036188|reactome:R-HSA-6803205|reactome:R-HSA-8873719|reactome:R-HSA-8876198|go:"GO:0016192"(vesicle-mediated transport)|refseq:NP_001307888.1|refseq:NP_000381.1|refseq:NP_001138886.1 ensembl:ENSG00000198612(gene)|ensembl:ENST00000354371(transcript)|go:"GO:0000338"(protein deneddylation)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010387"(COP9 signalosome assembly)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR033205|interpro:IPR033464|mint:Q99627|rcsb pdb:4D10|rcsb pdb:4D18|rcsb pdb:4WSN|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|rcsb pdb:6R7N|reactome:R-HSA-5696394|reactome:R-HSA-6781823|reactome:R-HSA-8856825|reactome:R-HSA-8951664|go:"GO:0006468"(protein phosphorylation)|refseq:NP_006701.1|refseq:NP_937832.1|dip:DIP-42075N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/07/08 rogid:lLHJ/D4ljKMp+kSHMHu9RUTdcps9606 rogid:3L+8IdjEw+ZC5MERztdPAY2ww389606 intact-crc:02E62AA95A194E51|rigid:OZZTjyWFxESXZbq4Dy5CU5tDT8c false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P24386 uniprotkb:Q9Y5S9 intact:EBI-2515129|ensembl:ENSP00000350386|uniprotkb:O43732|uniprotkb:A1L4D2 intact:EBI-447231|uniprotkb:Q6FHD1|uniprotkb:Q6IQ40|uniprotkb:Q9GZX8|uniprotkb:Q9NZI4|uniprotkb:B3KQI9|intact:EBI-28979675|ensembl:ENSP00000463058|ensembl:ENSP00000488265 psi-mi:rae1_human(display_long)|uniprotkb:CHM(gene name)|psi-mi:CHM(display_short)|uniprotkb:REP1(gene name synonym)|uniprotkb:TCD(gene name synonym)|uniprotkb:Rab escort protein 1(gene name synonym)|uniprotkb:TCD protein(gene name synonym)|uniprotkb:Choroideremia protein(gene name synonym) psi-mi:rbm8a_human(display_long)|uniprotkb:HSPC114(orf name)|uniprotkb:MDS014(orf name)|uniprotkb:RNA-binding motif protein 8A(gene name synonym)|uniprotkb:Ribonucleoprotein RBM8A(gene name synonym)|uniprotkb:RNA-binding protein Y14(gene name synonym)|uniprotkb:Binder of OVCA1-1(gene name synonym)|uniprotkb:RBM8A(gene name)|psi-mi:RBM8A(display_short)|uniprotkb:RBM8(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515120|imex:IM-12079-96 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000188419(gene)|ensembl:ENST00000357749(transcript)|go:"GO:0004663"(Rab geranylgeranyltransferase activity)|go:"GO:0005092"(GDP-dissociation inhibitor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005968"(Rab-protein geranylgeranyltransferase complex)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0007601"(visual perception)|go:"GO:0018344"(protein geranylgeranylation)|go:"GO:0031267"(small GTPase binding)|interpro:IPR001738("Rab escort (choroideraemia) protein")|interpro:IPR018203|interpro:IPR036188|reactome:R-HSA-6803205|reactome:R-HSA-8873719|reactome:R-HSA-8876198|go:"GO:0016192"(vesicle-mediated transport)|refseq:NP_001307888.1|refseq:NP_000381.1|refseq:NP_001138886.1 refseq:NP_005096.1|ensembl:ENST00000369307|ensembl:ENSP00000358313|ensembl:ENSP00000463058|ensembl:ENSP00000488265|dip:DIP-33070N|ensembl:ENSG00000265241(gene)|ensembl:ENST00000583313(transcript)|ensembl:ENST00000632555(transcript)|go:"GO:0000184"(nuclear-transcribed mRNA catabolic process, nonsense-mediated decay)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006417"(regulation of translation)|go:"GO:0008380"(RNA splicing)|go:"GO:0016607"(nuclear speck)|go:"GO:0030425"(dendrite)|go:"GO:0035145"(exon-exon junction complex)|go:"GO:0043025"(neuronal cell body)|go:"GO:0051028"(mRNA transport)|go:"GO:0071006"(U2-type catalytic step 1 spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR008111(RNA binding motif protein 8)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR033744|interpro:IPR035979|mint:Q9Y5S9|rcsb pdb:1P27|rcsb pdb:2HYI|rcsb pdb:2J0Q|rcsb pdb:2J0S|rcsb pdb:2XB2|rcsb pdb:3EX7|rcsb pdb:5XJC|rcsb pdb:5YZG|rcsb pdb:6ICZ|rcsb pdb:6QDV|rcsb pdb:7A5P|reactome:R-HSA-159236|reactome:R-HSA-72163|reactome:R-HSA-72187|reactome:R-HSA-73856|reactome:R-HSA-9010553|reactome:R-HSA-975957 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/07/08 rogid:lLHJ/D4ljKMp+kSHMHu9RUTdcps9606 rogid:7WdTcDs4RqjiKDSkHF0fFD8rAb09606 intact-crc:02E62AA95A194E51|rigid:OZZTjyWFxESXZbq4Dy5CU5tDT8c false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P24386 uniprotkb:Q9UDY2 intact:EBI-2515129|ensembl:ENSP00000350386|uniprotkb:O43732|uniprotkb:A1L4D2 intact:EBI-1042602|uniprotkb:Q15883|uniprotkb:Q5VXL0|uniprotkb:Q8N756|uniprotkb:Q8NI14|uniprotkb:Q99839|uniprotkb:Q9UDY0|uniprotkb:Q9UDY1|uniprotkb:A2A3H9|uniprotkb:Q5VXL1|intact:EBI-10989219|ensembl:ENSP00000366453|uniprotkb:B7Z2R8|uniprotkb:B7Z7T6|uniprotkb:F5H301|uniprotkb:F5H886 psi-mi:rae1_human(display_long)|uniprotkb:CHM(gene name)|psi-mi:CHM(display_short)|uniprotkb:REP1(gene name synonym)|uniprotkb:TCD(gene name synonym)|uniprotkb:Rab escort protein 1(gene name synonym)|uniprotkb:TCD protein(gene name synonym)|uniprotkb:Choroideremia protein(gene name synonym) psi-mi:zo2_human(display_long)|uniprotkb:TJP2(gene name)|psi-mi:TJP2(display_short)|uniprotkb:X104(gene name synonym)|uniprotkb:Zonula occludens protein 2(gene name synonym)|uniprotkb:Zona occludens protein 2(gene name synonym)|uniprotkb:Tight junction protein 2(gene name synonym)|uniprotkb:ZO2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515120|imex:IM-12079-96 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000188419(gene)|ensembl:ENST00000357749(transcript)|go:"GO:0004663"(Rab geranylgeranyltransferase activity)|go:"GO:0005092"(GDP-dissociation inhibitor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005968"(Rab-protein geranylgeranyltransferase complex)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0007601"(visual perception)|go:"GO:0018344"(protein geranylgeranylation)|go:"GO:0031267"(small GTPase binding)|interpro:IPR001738("Rab escort (choroideraemia) protein")|interpro:IPR018203|interpro:IPR036188|reactome:R-HSA-6803205|reactome:R-HSA-8873719|reactome:R-HSA-8876198|go:"GO:0016192"(vesicle-mediated transport)|refseq:NP_001307888.1|refseq:NP_000381.1|refseq:NP_001138886.1 refseq:NP_001163886.1|refseq:NP_001163887.1|refseq:NP_004808.2|refseq:XP_011517508.1|refseq:XP_011517509.1|refseq:XP_011517510.1|refseq:XP_011517511.1|ensembl:ENSG00000119139(gene)|ensembl:ENST00000377245(transcript)|go:"GO:0004385"(guanylate kinase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0034109"(homotypic cell-cell adhesion)|go:"GO:0035633"(maintenance of blood-brain barrier)|go:"GO:0044291"(cell-cell contact zone)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0045296"(cadherin binding)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050892"(intestinal absorption)|go:"GO:0090557"(establishment of endothelial intestinal barrier)|go:"GO:0090559"(regulation of membrane permeability)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0150105"(protein localization to cell-cell junction)|go:"GO:1905605"(positive regulation of blood-brain barrier permeability)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR005417(Zona occludens protein)|interpro:IPR005419(Zona occludens protein ZO-2)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR027417|interpro:IPR035598|interpro:IPR036028|interpro:IPR036034|mint:Q9UDY2|rcsb pdb:2OSG|rcsb pdb:3E17|reactome:R-HSA-2028269|reactome:R-HSA-351906|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/07/08 rogid:lLHJ/D4ljKMp+kSHMHu9RUTdcps9606 rogid:iN/EF8QWKtekoj5eON764eKAdpg9606 intact-crc:02E62AA95A194E51|rigid:OZZTjyWFxESXZbq4Dy5CU5tDT8c false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P24386 uniprotkb:Q9Y535 intact:EBI-2515129|ensembl:ENSP00000350386|uniprotkb:O43732|uniprotkb:A1L4D2 intact:EBI-2515065|uniprotkb:Q9BY95|uniprotkb:Q96AE3|uniprotkb:B0QYH9|uniprotkb:Q5M7Y8|ensembl:ENSP00000347345|ensembl:ENSP00000379761|ensembl:ENSP00000385315 psi-mi:rae1_human(display_long)|uniprotkb:CHM(gene name)|psi-mi:CHM(display_short)|uniprotkb:REP1(gene name synonym)|uniprotkb:TCD(gene name synonym)|uniprotkb:Rab escort protein 1(gene name synonym)|uniprotkb:TCD protein(gene name synonym)|uniprotkb:Choroideremia protein(gene name synonym) psi-mi:rpc8_human(display_long)|uniprotkb:POLR3H(gene name)|psi-mi:POLR3H(display_short)|uniprotkb:KIAA1665(gene name synonym)|uniprotkb:DNA-directed RNA polymerase III subunit H(gene name synonym)|uniprotkb:RPC8(gene name synonym)|uniprotkb:RNA polymerase III subunit 22.9 kDa subunit(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515120|imex:IM-12079-96 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000188419(gene)|ensembl:ENST00000357749(transcript)|go:"GO:0004663"(Rab geranylgeranyltransferase activity)|go:"GO:0005092"(GDP-dissociation inhibitor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005968"(Rab-protein geranylgeranyltransferase complex)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0007601"(visual perception)|go:"GO:0018344"(protein geranylgeranylation)|go:"GO:0031267"(small GTPase binding)|interpro:IPR001738("Rab escort (choroideraemia) protein")|interpro:IPR018203|interpro:IPR036188|reactome:R-HSA-6803205|reactome:R-HSA-8873719|reactome:R-HSA-8876198|go:"GO:0016192"(vesicle-mediated transport)|refseq:NP_001307888.1|refseq:NP_000381.1|refseq:NP_001138886.1 refseq:NP_001269813.1|refseq:NP_001269814.1|refseq:NP_001018060.1|refseq:NP_001018062.1|refseq:NP_612211.1|reactome:R-HSA-73980|reactome:R-HSA-749476|reactome:R-HSA-76061|reactome:R-HSA-76066|reactome:R-HSA-76071|ensembl:ENSG00000100413(gene)|ensembl:ENST00000355209(transcript)|ensembl:ENST00000396504(transcript)|ensembl:ENST00000407461(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003899"(DNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005666"(RNA polymerase III complex)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006139"(nucleobase-containing compound metabolic process)|go:"GO:0006383"(transcription by RNA polymerase III)|go:"GO:0006384"(transcription initiation from RNA polymerase III promoter)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045087"(innate immune response)|go:"GO:0051607"(defense response to virus)|interpro:IPR004519(DNA-directed RNA polymerase)|interpro:IPR005576(RNA polymerase Rpb7, N-terminal)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR013238(RNA polymerase III, subunit Rpc25)|interpro:IPR036898|mint:Q9Y535|rcsb pdb:7A6H|rcsb pdb:7AE1|rcsb pdb:7AE3|rcsb pdb:7AEA|rcsb pdb:7AST|rcsb pdb:7D58|rcsb pdb:7D59|rcsb pdb:7DN3|rcsb pdb:7DU2|reactome:R-HSA-1834949|reactome:R-HSA-73780 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/07/08 rogid:lLHJ/D4ljKMp+kSHMHu9RUTdcps9606 rogid:iZrzO9t581Oy9db2/+cpcy7uLL09606 intact-crc:02E62AA95A194E51|rigid:OZZTjyWFxESXZbq4Dy5CU5tDT8c false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P24386 uniprotkb:O94806 intact:EBI-2515129|ensembl:ENSP00000350386|uniprotkb:O43732|uniprotkb:A1L4D2 intact:EBI-1255366|uniprotkb:Q53TR7|uniprotkb:Q8NEL8|uniprotkb:D6W587|ensembl:ENSP00000368356|ensembl:ENSP00000234179 psi-mi:rae1_human(display_long)|uniprotkb:CHM(gene name)|psi-mi:CHM(display_short)|uniprotkb:REP1(gene name synonym)|uniprotkb:TCD(gene name synonym)|uniprotkb:Rab escort protein 1(gene name synonym)|uniprotkb:TCD protein(gene name synonym)|uniprotkb:Choroideremia protein(gene name synonym) psi-mi:kpcd3_human(display_long)|uniprotkb:PRKD3(gene name)|psi-mi:PRKD3(display_short)|uniprotkb:EPK2(gene name synonym)|uniprotkb:PRKCN(gene name synonym)|uniprotkb:Protein kinase C nu type(gene name synonym)|uniprotkb:nPKC-nu(gene name synonym)|uniprotkb:Protein kinase EPK2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515120|imex:IM-12079-96 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000188419(gene)|ensembl:ENST00000357749(transcript)|go:"GO:0004663"(Rab geranylgeranyltransferase activity)|go:"GO:0005092"(GDP-dissociation inhibitor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005968"(Rab-protein geranylgeranyltransferase complex)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0007601"(visual perception)|go:"GO:0018344"(protein geranylgeranylation)|go:"GO:0031267"(small GTPase binding)|interpro:IPR001738("Rab escort (choroideraemia) protein")|interpro:IPR018203|interpro:IPR036188|reactome:R-HSA-6803205|reactome:R-HSA-8873719|reactome:R-HSA-8876198|go:"GO:0016192"(vesicle-mediated transport)|refseq:NP_001307888.1|refseq:NP_000381.1|refseq:NP_001138886.1 refseq:NP_005804.1|refseq:XP_005264294.1|ensembl:ENSG00000115825(gene)|ensembl:ENST00000234179(transcript)|ensembl:ENST00000379066(transcript)|go:"GO:0004697"(protein kinase C activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007205"(protein kinase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0030148"(sphingolipid biosynthetic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0089700"(protein kinase D signaling)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR015727(Protein kinase C mu-related)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020454|rcsb pdb:2D9Z|reactome:R-HSA-1660661 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/07/08 rogid:lLHJ/D4ljKMp+kSHMHu9RUTdcps9606 rogid:UgwsN9a5nJT53K2HrD1E94A5HWc9606 intact-crc:02E62AA95A194E51|rigid:OZZTjyWFxESXZbq4Dy5CU5tDT8c false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P24386 uniprotkb:Q8N1F7 intact:EBI-2515129|ensembl:ENSP00000350386|uniprotkb:O43732|uniprotkb:A1L4D2 intact:EBI-1042703|uniprotkb:Q14705|uniprotkb:B3KPQ8|ensembl:ENSP00000310668 psi-mi:rae1_human(display_long)|uniprotkb:CHM(gene name)|psi-mi:CHM(display_short)|uniprotkb:REP1(gene name synonym)|uniprotkb:TCD(gene name synonym)|uniprotkb:Rab escort protein 1(gene name synonym)|uniprotkb:TCD protein(gene name synonym)|uniprotkb:Choroideremia protein(gene name synonym) psi-mi:nup93_human(display_long)|uniprotkb:NUP93(gene name)|psi-mi:NUP93(display_short)|uniprotkb:KIAA0095(gene name synonym)|uniprotkb:Nucleoporin Nup93(gene name synonym)|uniprotkb:93 kDa nucleoporin(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515120|imex:IM-12079-96 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000188419(gene)|ensembl:ENST00000357749(transcript)|go:"GO:0004663"(Rab geranylgeranyltransferase activity)|go:"GO:0005092"(GDP-dissociation inhibitor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005968"(Rab-protein geranylgeranyltransferase complex)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0007601"(visual perception)|go:"GO:0018344"(protein geranylgeranylation)|go:"GO:0031267"(small GTPase binding)|interpro:IPR001738("Rab escort (choroideraemia) protein")|interpro:IPR018203|interpro:IPR036188|reactome:R-HSA-6803205|reactome:R-HSA-8873719|reactome:R-HSA-8876198|go:"GO:0016192"(vesicle-mediated transport)|refseq:NP_001307888.1|refseq:NP_000381.1|refseq:NP_001138886.1 refseq:NP_055484.3|refseq:NP_001229724.1|refseq:NP_001229725.1|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006998"(nuclear envelope organization)|go:"GO:0016020"(membrane)|go:"GO:0016973"("poly(A)+ mRNA export from nucleus")|go:"GO:0017056"(structural constituent of nuclear pore)|go:"GO:0031965"(nuclear membrane)|go:"GO:0034399"(nuclear periphery)|go:"GO:0051292"(nuclear pore complex assembly)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060395"(SMAD protein signal transduction)|interpro:IPR007231(Nucleoporin interacting component)|mint:Q8N1F7|rcsb pdb:5IJN|rcsb pdb:5IJO|reactome:R-HSA-1169408|reactome:R-HSA-159227|reactome:R-HSA-159230|reactome:R-HSA-159231|reactome:R-HSA-159236|reactome:R-HSA-165054|ensembl:ENSG00000102900(gene)|reactome:R-HSA-168271|ensembl:ENST00000308159(transcript)|go:"GO:0005635"(nuclear envelope)|reactome:R-HSA-168276|go:"GO:0005643"(nuclear pore)|reactome:R-HSA-168325|reactome:R-HSA-168333|reactome:R-HSA-170822|reactome:R-HSA-180746|reactome:R-HSA-180910|reactome:R-HSA-3108214|reactome:R-HSA-3232142|reactome:R-HSA-3301854|reactome:R-HSA-3371453|reactome:R-HSA-191859|reactome:R-HSA-4085377|reactome:R-HSA-4551638|reactome:R-HSA-4570464|reactome:R-HSA-4615885|reactome:R-HSA-5578749|reactome:R-HSA-5619107|reactome:R-HSA-6784531|reactome:R-HSA-9609690|reactome:R-HSA-9610379|reactome:R-HSA-9615933|refseq:XP_005256320.1|dip:DIP-44020N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/07/08 rogid:lLHJ/D4ljKMp+kSHMHu9RUTdcps9606 rogid:pkk5pooUC4yQShpqjiwNLddfy149606 intact-crc:02E62AA95A194E51|rigid:OZZTjyWFxESXZbq4Dy5CU5tDT8c false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P24386 uniprotkb:O14802 intact:EBI-2515129|ensembl:ENSP00000350386|uniprotkb:O43732|uniprotkb:A1L4D2 intact:EBI-2515113|ensembl:ENSP00000361446|uniprotkb:Q8TCW5|uniprotkb:Q8IW34 psi-mi:rae1_human(display_long)|uniprotkb:CHM(gene name)|psi-mi:CHM(display_short)|uniprotkb:REP1(gene name synonym)|uniprotkb:TCD(gene name synonym)|uniprotkb:Rab escort protein 1(gene name synonym)|uniprotkb:TCD protein(gene name synonym)|uniprotkb:Choroideremia protein(gene name synonym) psi-mi:rpc1_human(display_long)|uniprotkb:POLR3A(gene name)|psi-mi:POLR3A(display_short)|uniprotkb:DNA-directed RNA polymerase III subunit A(gene name synonym)|uniprotkb:DNA-directed RNA polymerase III largest subunit(gene name synonym)|uniprotkb:RNA polymerase III 155 kDa subunit(gene name synonym)|uniprotkb:RNA polymerase III subunit C160(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515120|imex:IM-12079-96 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000188419(gene)|ensembl:ENST00000357749(transcript)|go:"GO:0004663"(Rab geranylgeranyltransferase activity)|go:"GO:0005092"(GDP-dissociation inhibitor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005968"(Rab-protein geranylgeranyltransferase complex)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0007601"(visual perception)|go:"GO:0018344"(protein geranylgeranylation)|go:"GO:0031267"(small GTPase binding)|interpro:IPR001738("Rab escort (choroideraemia) protein")|interpro:IPR018203|interpro:IPR036188|reactome:R-HSA-6803205|reactome:R-HSA-8873719|reactome:R-HSA-8876198|go:"GO:0016192"(vesicle-mediated transport)|refseq:NP_001307888.1|refseq:NP_000381.1|refseq:NP_001138886.1 ensembl:ENSG00000148606(gene)|ensembl:ENST00000372371(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003899"(DNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005666"(RNA polymerase III complex)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0016020"(membrane)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0045087"(innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0051607"(defense response to virus)|interpro:IPR000722(RNA polymerase, alpha subunit)|interpro:IPR006592(RNA polymerase, N-terminal)|interpro:IPR007066(RNA polymerase Rpb1, domain 3)|interpro:IPR007080(RNA polymerase Rpb1, domain 1)|interpro:IPR007081(RNA polymerase Rpb1, domain 5)|interpro:IPR007083(RNA polymerase Rpb1, domain 4)|interpro:IPR035697|interpro:IPR035698|interpro:IPR038120|interpro:IPR042102|mint:O14802|rcsb pdb:7A6H|rcsb pdb:7AE3|rcsb pdb:7AEA|rcsb pdb:7AST|rcsb pdb:7D58|rcsb pdb:7D59|rcsb pdb:7DN3|rcsb pdb:7DU2|reactome:R-HSA-1834949|reactome:R-HSA-73780|reactome:R-HSA-73980|reactome:R-HSA-749476|rcsb pdb:7AE1|reactome:R-HSA-76061|reactome:R-HSA-76066|reactome:R-HSA-76071|refseq:NP_008986.2 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/07/08 rogid:lLHJ/D4ljKMp+kSHMHu9RUTdcps9606 rogid:aIkROXC0f3CXTeRzAvW+lyXSmTE9606 intact-crc:02E62AA95A194E51|rigid:OZZTjyWFxESXZbq4Dy5CU5tDT8c false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P24386 uniprotkb:P49643 intact:EBI-2515129|ensembl:ENSP00000350386|uniprotkb:O43732|uniprotkb:A1L4D2 intact:EBI-850004|uniprotkb:Q53FJ8|uniprotkb:Q6P1Q7|uniprotkb:Q8WVL2|uniprotkb:Q9H413|ensembl:ENSP00000484105 psi-mi:rae1_human(display_long)|uniprotkb:CHM(gene name)|psi-mi:CHM(display_short)|uniprotkb:REP1(gene name synonym)|uniprotkb:TCD(gene name synonym)|uniprotkb:Rab escort protein 1(gene name synonym)|uniprotkb:TCD protein(gene name synonym)|uniprotkb:Choroideremia protein(gene name synonym) psi-mi:pri2_human(display_long)|uniprotkb:DNA primase 58 kDa subunit(gene name synonym)|uniprotkb:PRIM2(gene name)|psi-mi:PRIM2(display_short)|uniprotkb:PRIM2A(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515120|imex:IM-12079-96 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000188419(gene)|ensembl:ENST00000357749(transcript)|go:"GO:0004663"(Rab geranylgeranyltransferase activity)|go:"GO:0005092"(GDP-dissociation inhibitor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005968"(Rab-protein geranylgeranyltransferase complex)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0007601"(visual perception)|go:"GO:0018344"(protein geranylgeranylation)|go:"GO:0031267"(small GTPase binding)|interpro:IPR001738("Rab escort (choroideraemia) protein")|interpro:IPR018203|interpro:IPR036188|reactome:R-HSA-6803205|reactome:R-HSA-8873719|reactome:R-HSA-8876198|go:"GO:0016192"(vesicle-mediated transport)|refseq:NP_001307888.1|refseq:NP_000381.1|refseq:NP_001138886.1 refseq:NP_001269416.1|refseq:NP_001269417.1|refseq:NP_000938.2|dip:DIP-36438N|ensembl:ENSG00000146143(gene)|ensembl:ENST00000615550(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005658"("alpha DNA polymerase:primase complex")|go:"GO:0006269"(DNA replication, synthesis of RNA primer)|go:"GO:0046872"(metal ion binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0071667"(DNA/RNA hybrid binding)|interpro:IPR007238(DNA primase, large subunit, eukaryotic/archaeal)|interpro:IPR016558(DNA primase, large subunit, eukaryotic)|mint:P49643|rcsb pdb:3L9Q|rcsb pdb:3Q36|rcsb pdb:4BPU|rcsb pdb:4BPW|rcsb pdb:4BPX|rcsb pdb:4RR2|rcsb pdb:5DQO|rcsb pdb:5EXR|rcsb pdb:5F0Q|rcsb pdb:5F0S|rcsb pdb:5I7M|rcsb pdb:6DHW|reactome:R-HSA-113501|reactome:R-HSA-174411|reactome:R-HSA-174430|reactome:R-HSA-68952|reactome:R-HSA-68962|reactome:R-HSA-69091|reactome:R-HSA-69166|reactome:R-HSA-69183|reactome:R-HSA-9710421 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/07/08 rogid:lLHJ/D4ljKMp+kSHMHu9RUTdcps9606 rogid:WL5i+CvK52C93/3X4a3MFQvD0JQ9606 intact-crc:02E62AA95A194E51|rigid:OZZTjyWFxESXZbq4Dy5CU5tDT8c false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P24386 uniprotkb:P14625 intact:EBI-2515129|ensembl:ENSP00000350386|uniprotkb:O43732|uniprotkb:A1L4D2 intact:EBI-359129|uniprotkb:Q96A97|ensembl:ENSP00000299767 psi-mi:rae1_human(display_long)|uniprotkb:CHM(gene name)|psi-mi:CHM(display_short)|uniprotkb:REP1(gene name synonym)|uniprotkb:TCD(gene name synonym)|uniprotkb:Rab escort protein 1(gene name synonym)|uniprotkb:TCD protein(gene name synonym)|uniprotkb:Choroideremia protein(gene name synonym) psi-mi:enpl_human(display_long)|uniprotkb:HSP90B1(gene name)|psi-mi:HSP90B1(display_short)|uniprotkb:TRA1(gene name synonym)|uniprotkb:Heat shock protein 90 kDa beta member 1(gene name synonym)|uniprotkb:94 kDa glucose-regulated protein(gene name synonym)|uniprotkb:GRP94(gene name synonym)|uniprotkb:gp96 homolog(gene name synonym)|uniprotkb:Tumor rejection antigen 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515120|imex:IM-12079-96 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000188419(gene)|ensembl:ENST00000357749(transcript)|go:"GO:0004663"(Rab geranylgeranyltransferase activity)|go:"GO:0005092"(GDP-dissociation inhibitor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005968"(Rab-protein geranylgeranyltransferase complex)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0007601"(visual perception)|go:"GO:0018344"(protein geranylgeranylation)|go:"GO:0031267"(small GTPase binding)|interpro:IPR001738("Rab escort (choroideraemia) protein")|interpro:IPR018203|interpro:IPR036188|reactome:R-HSA-6803205|reactome:R-HSA-8873719|reactome:R-HSA-8876198|go:"GO:0016192"(vesicle-mediated transport)|refseq:NP_001307888.1|refseq:NP_000381.1|refseq:NP_001138886.1 refseq:NP_003290.1|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050750"(low-density lipoprotein particle receptor binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051208"(sequestering of calcium ion)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071318"(cellular response to ATP)|go:"GO:0071682"(endocytic vesicle lumen)|interpro:IPR001404(Heat shock protein Hsp90)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR019805|interpro:IPR020568|interpro:IPR020575|interpro:IPR036890|interpro:IPR037196|mint:P14625|rcsb pdb:4NH9|reactome:R-HSA-1679131|reactome:R-HSA-3000480|reactome:R-HSA-381183|reactome:R-HSA-381426|reactome:R-HSA-6785807|reactome:R-HSA-8957275|ensembl:ENSG00000166598(gene)|ensembl:ENST00000299767(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0003723"(RNA binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006457"(protein folding)|go:"GO:0015031"(protein transport)|go:"GO:0016020"(membrane)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030496"(midbody)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0031247"(actin rod assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033018"(sarcoplasmic reticulum lumen)|go:"GO:0034663"(endoplasmic reticulum chaperone complex)|go:"GO:0034975"(protein folding in endoplasmic reticulum)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0042470"(melanosome)|dip:DIP-36060N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/07/08 rogid:lLHJ/D4ljKMp+kSHMHu9RUTdcps9606 rogid:m5CdlplqVyMUWYe75aKDuMzztMY9606 intact-crc:02E62AA95A194E51|rigid:OZZTjyWFxESXZbq4Dy5CU5tDT8c false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P24386 uniprotkb:P25325 intact:EBI-2515129|ensembl:ENSP00000350386|uniprotkb:O43732|uniprotkb:A1L4D2 intact:EBI-2515082|ensembl:ENSP00000342333|ensembl:ENSP00000380402|ensembl:ENSP00000383950|ensembl:ENSP00000384812|uniprotkb:O75750|uniprotkb:A8MZ34|uniprotkb:B3KP52|uniprotkb:J3KPV7|uniprotkb:Q6FHN9 psi-mi:rae1_human(display_long)|uniprotkb:CHM(gene name)|psi-mi:CHM(display_short)|uniprotkb:REP1(gene name synonym)|uniprotkb:TCD(gene name synonym)|uniprotkb:Rab escort protein 1(gene name synonym)|uniprotkb:TCD protein(gene name synonym)|uniprotkb:Choroideremia protein(gene name synonym) psi-mi:thtm_human(display_long)|uniprotkb:MPST(gene name)|psi-mi:MPST(display_short)|uniprotkb:TST2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515120|imex:IM-12079-96 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000188419(gene)|ensembl:ENST00000357749(transcript)|go:"GO:0004663"(Rab geranylgeranyltransferase activity)|go:"GO:0005092"(GDP-dissociation inhibitor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005968"(Rab-protein geranylgeranyltransferase complex)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0007601"(visual perception)|go:"GO:0018344"(protein geranylgeranylation)|go:"GO:0031267"(small GTPase binding)|interpro:IPR001738("Rab escort (choroideraemia) protein")|interpro:IPR018203|interpro:IPR036188|reactome:R-HSA-6803205|reactome:R-HSA-8873719|reactome:R-HSA-8876198|go:"GO:0016192"(vesicle-mediated transport)|refseq:NP_001307888.1|refseq:NP_000381.1|refseq:NP_001138886.1 go:"GO:0070062"(extracellular exosome)|go:"GO:0070814"(hydrogen sulfide biosynthetic process)|interpro:IPR001307(Thiosulphate sulphurtransferase, conserved site)|interpro:IPR001763(Rhodanese-like)|interpro:IPR036873|mint:P25325|rcsb pdb:3OLH|rcsb pdb:4JGT|reactome:R-HSA-1614558|ensembl:ENSG00000128309(gene)|ensembl:ENST00000341116(transcript)|ensembl:ENST00000397225(transcript)|ensembl:ENST00000401419(transcript)|ensembl:ENST00000404802(transcript)|go:"GO:0000098"(sulfur amino acid catabolic process)|go:"GO:0001822"(kidney development)|go:"GO:0001889"(liver development)|go:"GO:0004792"(thiosulfate sulfurtransferase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0009440"(cyanate catabolic process)|go:"GO:0009636"(response to toxic substance)|go:"GO:0016784"(3-mercaptopyruvate sulfurtransferase activity)|go:"GO:0019346"(transsulfuration)|go:"GO:0021510"(spinal cord development)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0045202"(synapse)|refseq:NP_001013454.1|refseq:NP_001123989.1|refseq:NP_066949.2|refseq:XP_005261667.1|dip:DIP-613N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/07/08 rogid:lLHJ/D4ljKMp+kSHMHu9RUTdcps9606 rogid:JDsHqxXe71bbWhgF2GcXCOspbpQ9606 intact-crc:02E62AA95A194E51|rigid:OZZTjyWFxESXZbq4Dy5CU5tDT8c false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P24386 uniprotkb:P37198 intact:EBI-2515129|ensembl:ENSP00000350386|uniprotkb:O43732|uniprotkb:A1L4D2 intact:EBI-347978|intact:EBI-28983799|ensembl:ENSP00000305503|ensembl:ENSP00000407331|ensembl:ENSP00000471191|ensembl:ENSP00000473192|uniprotkb:Q6GTM2|uniprotkb:Q503A4|uniprotkb:Q96C43|uniprotkb:Q9NSL1|uniprotkb:B3KWU5 psi-mi:rae1_human(display_long)|uniprotkb:CHM(gene name)|psi-mi:CHM(display_short)|uniprotkb:REP1(gene name synonym)|uniprotkb:TCD(gene name synonym)|uniprotkb:Rab escort protein 1(gene name synonym)|uniprotkb:TCD protein(gene name synonym)|uniprotkb:Choroideremia protein(gene name synonym) psi-mi:nup62_human(display_long)|uniprotkb:NUP62(gene name)|psi-mi:NUP62(display_short)|uniprotkb:62 kDa nucleoporin(gene name synonym)|uniprotkb:Nucleoporin Nup62(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515120|imex:IM-12079-96 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000188419(gene)|ensembl:ENST00000357749(transcript)|go:"GO:0004663"(Rab geranylgeranyltransferase activity)|go:"GO:0005092"(GDP-dissociation inhibitor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005968"(Rab-protein geranylgeranyltransferase complex)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0007601"(visual perception)|go:"GO:0018344"(protein geranylgeranylation)|go:"GO:0031267"(small GTPase binding)|interpro:IPR001738("Rab escort (choroideraemia) protein")|interpro:IPR018203|interpro:IPR036188|reactome:R-HSA-6803205|reactome:R-HSA-8873719|reactome:R-HSA-8876198|go:"GO:0016192"(vesicle-mediated transport)|refseq:NP_001307888.1|refseq:NP_000381.1|refseq:NP_001138886.1 refseq:NP_714941.1|ensembl:ENSG00000213024(gene)|ensembl:ENST00000352066(transcript)|ensembl:ENST00000422090(transcript)|ensembl:ENST00000596217(transcript)|ensembl:ENST00000597029(transcript)|go:"GO:0000922"(spindle pole)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005642"(annulate lamellae)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0006405"(RNA export from nucleus)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007100"(mitotic centrosome separation)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007569"(cell aging)|go:"GO:0008219"(cell death)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009966"(regulation of signal transduction)|go:"GO:0003682"(chromatin binding)|go:"GO:0017056"(structural constituent of nuclear pore)|go:"GO:0019894"(kinesin binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042306"(regulation of protein import into nucleus)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043069"(negative regulation of programmed cell death)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0044613"(nuclear pore central transport channel)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046578"(regulation of Ras protein signal transduction)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0046601"(positive regulation of centriole replication)|go:"GO:0051028"(mRNA transport)|go:"GO:0051425"(PTB domain binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060236"(regulation of mitotic spindle organization)|go:"GO:0072686"(mitotic spindle)|reactome:R-HSA-3371453|reactome:R-HSA-4085377|reactome:R-HSA-4551638|reactome:R-HSA-4570464|reactome:R-HSA-4615885|reactome:R-HSA-5578749|reactome:R-HSA-5619107|reactome:R-HSA-6784531|reactome:R-HSA-9609690|reactome:R-HSA-9610379|reactome:R-HSA-9615933|go:"GO:0090543"(Flemming body)|go:"GO:0098534"(centriole assembly)|go:"GO:1903438"(positive regulation of mitotic cytokinetic process)|go:"GO:1904781"(positive regulation of protein localization to centrosome)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR007758(Nucleoporin, Nsp1-like, C-terminal)|interpro:IPR026010|interpro:IPR033072|mint:P37198|rcsb pdb:2H4D|rcsb pdb:5IJN|rcsb pdb:5IJO|reactome:R-HSA-1169408|reactome:R-HSA-159227|reactome:R-HSA-159230|reactome:R-HSA-159231|reactome:R-HSA-159236|reactome:R-HSA-165054|reactome:R-HSA-168271|reactome:R-HSA-168276|reactome:R-HSA-168325|reactome:R-HSA-168333|reactome:R-HSA-170822|reactome:R-HSA-180746|reactome:R-HSA-180910|reactome:R-HSA-191859|reactome:R-HSA-3108214|reactome:R-HSA-3232142|reactome:R-HSA-3301854|refseq:NP_714940.1|refseq:NP_001180286.1|refseq:NP_036478.2|refseq:NP_057637.2|ensembl:ENSP00000305503|ensembl:ENSP00000407331|ensembl:ENSP00000471191|ensembl:ENSP00000473192|dip:DIP-29749N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/07/08 rogid:lLHJ/D4ljKMp+kSHMHu9RUTdcps9606 rogid:v7mvKvTtVEnLMwcpUZIcdAzge009606 intact-crc:02E62AA95A194E51|rigid:OZZTjyWFxESXZbq4Dy5CU5tDT8c false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P24386 uniprotkb:P46821 intact:EBI-2515129|ensembl:ENSP00000350386|uniprotkb:O43732|uniprotkb:A1L4D2 intact:EBI-764611|uniprotkb:A2BDK5|ensembl:ENSP00000296755 psi-mi:rae1_human(display_long)|uniprotkb:CHM(gene name)|psi-mi:CHM(display_short)|uniprotkb:REP1(gene name synonym)|uniprotkb:TCD(gene name synonym)|uniprotkb:Rab escort protein 1(gene name synonym)|uniprotkb:TCD protein(gene name synonym)|uniprotkb:Choroideremia protein(gene name synonym) psi-mi:map1b_human(display_long)|uniprotkb:MAP1B(gene name)|psi-mi:MAP1B(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515120|imex:IM-12079-96 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000188419(gene)|ensembl:ENST00000357749(transcript)|go:"GO:0004663"(Rab geranylgeranyltransferase activity)|go:"GO:0005092"(GDP-dissociation inhibitor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005968"(Rab-protein geranylgeranyltransferase complex)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0007601"(visual perception)|go:"GO:0018344"(protein geranylgeranylation)|go:"GO:0031267"(small GTPase binding)|interpro:IPR001738("Rab escort (choroideraemia) protein")|interpro:IPR018203|interpro:IPR036188|reactome:R-HSA-6803205|reactome:R-HSA-8873719|reactome:R-HSA-8876198|go:"GO:0016192"(vesicle-mediated transport)|refseq:NP_001307888.1|refseq:NP_000381.1|refseq:NP_001138886.1 refseq:NP_005900.2|dip:DIP-33474N|ensembl:ENSG00000131711(gene)|ensembl:ENST00000296755(transcript)|go:"GO:0001578"(microtubule bundle formation)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0001764"(neuron migration)|go:"GO:0003779"(actin binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0007409"(axonogenesis)|go:"GO:0007416"(synapse assembly)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0008017"(microtubule binding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009743"(response to carbohydrate)|go:"GO:0009987"(cellular process)|go:"GO:0010035"(response to inorganic substance)|go:"GO:0014012"(peripheral nervous system axon regeneration)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016358"(dendrite development)|go:"GO:0021700"(developmental maturation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031114"(regulation of microtubule depolymerization)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0032355"(response to estradiol)|go:"GO:0032387"(negative regulation of intracellular transport)|go:"GO:0033189"(response to vitamin A)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042493"|go:"GO:0043025"(neuronal cell body)|go:"GO:0043196"(varicosity)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0017085"(response to insecticide)|go:"GO:0045202"(synapse)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0047497"(mitochondrion transport along microtubule)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0051915"(induction of synaptic plasticity by chemical substance)|go:"GO:0061162"(establishment of monopolar cell polarity)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0097440"(apical dendrite)|go:"GO:0097441"(basal dendrite)|go:"GO:0097457"(hippocampal mossy fiber)|interpro:IPR000102(Neuraxin/MAP1B repeat)|go:"GO:0044877"(protein-containing complex binding)|interpro:IPR027321|mint:P46821|interpro:IPR026074 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/07/08 rogid:lLHJ/D4ljKMp+kSHMHu9RUTdcps9606 rogid:uSRzrWaYU/dmkItUkCK4zex+/TM9606 intact-crc:02E62AA95A194E51|rigid:OZZTjyWFxESXZbq4Dy5CU5tDT8c false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P24386 uniprotkb:O43290 intact:EBI-2515129|ensembl:ENSP00000350386|uniprotkb:O43732|uniprotkb:A1L4D2 intact:EBI-607761|ensembl:ENSP00000310448|uniprotkb:A6NDN1|uniprotkb:Q53GB5 psi-mi:rae1_human(display_long)|uniprotkb:CHM(gene name)|psi-mi:CHM(display_short)|uniprotkb:REP1(gene name synonym)|uniprotkb:TCD(gene name synonym)|uniprotkb:Rab escort protein 1(gene name synonym)|uniprotkb:TCD protein(gene name synonym)|uniprotkb:Choroideremia protein(gene name synonym) psi-mi:snut1_human(display_long)|uniprotkb:U4/U6.U5 tri-snRNP-associated 110 kDa protein(gene name synonym)|uniprotkb:SART1(gene name)|psi-mi:SART1(display_short)|uniprotkb:SNU66 homolog(gene name synonym)|uniprotkb:Squamous cell carcinoma antigen recognized by T-cells 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515120|imex:IM-12079-96 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000188419(gene)|ensembl:ENST00000357749(transcript)|go:"GO:0004663"(Rab geranylgeranyltransferase activity)|go:"GO:0005092"(GDP-dissociation inhibitor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005968"(Rab-protein geranylgeranyltransferase complex)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0007601"(visual perception)|go:"GO:0018344"(protein geranylgeranylation)|go:"GO:0031267"(small GTPase binding)|interpro:IPR001738("Rab escort (choroideraemia) protein")|interpro:IPR018203|interpro:IPR036188|reactome:R-HSA-6803205|reactome:R-HSA-8873719|reactome:R-HSA-8876198|go:"GO:0016192"(vesicle-mediated transport)|refseq:NP_001307888.1|refseq:NP_000381.1|refseq:NP_001138886.1 ensembl:ENSG00000175467(gene)|ensembl:ENST00000312397(transcript)|go:"GO:0000387"(spliceosomal snRNP assembly)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000481"(maturation of 5S rRNA)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0015030"(Cajal body)|go:"GO:0016607"(nuclear speck)|go:"GO:0045292"(mRNA cis splicing, via spliceosome)|go:"GO:0045585"(positive regulation of cytotoxic T cell differentiation)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|interpro:IPR005011(SART-1 protein)|mint:O43290|rcsb pdb:4PYU|rcsb pdb:5O9Z|rcsb pdb:6AHD|rcsb pdb:6QW6|rcsb pdb:6QX9|reactome:R-HSA-72163|refseq:NP_005137.1|dip:DIP-33360N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/07/08 rogid:lLHJ/D4ljKMp+kSHMHu9RUTdcps9606 rogid:egvWHy7UXW+MkGtGEW984yvRU9k9606 intact-crc:02E62AA95A194E51|rigid:OZZTjyWFxESXZbq4Dy5CU5tDT8c false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P24386 uniprotkb:O15504 intact:EBI-2515129|ensembl:ENSP00000350386|uniprotkb:O43732|uniprotkb:A1L4D2 intact:EBI-2515057|ensembl:ENSP00000258742|uniprotkb:Q49AE7|uniprotkb:Q9BS49|uniprotkb:A4D143|uniprotkb:B4DP42|intact:EBI-13077614 psi-mi:rae1_human(display_long)|uniprotkb:CHM(gene name)|psi-mi:CHM(display_short)|uniprotkb:REP1(gene name synonym)|uniprotkb:TCD(gene name synonym)|uniprotkb:Rab escort protein 1(gene name synonym)|uniprotkb:TCD protein(gene name synonym)|uniprotkb:Choroideremia protein(gene name synonym) psi-mi:nup42_human(display_long)|uniprotkb:NUP42(gene name)|psi-mi:NUP42(display_short)|uniprotkb:CG1(gene name synonym)|uniprotkb:NLP-1(gene name synonym)|uniprotkb:NUP42 homolog(gene name synonym)|uniprotkb:NUPL2(gene name synonym)|uniprotkb:Nucleoporin hCG1(gene name synonym)|uniprotkb:Nucleoporin-42(gene name synonym)|uniprotkb:Nucleoporin-like protein 2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515120|imex:IM-12079-96 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000188419(gene)|ensembl:ENST00000357749(transcript)|go:"GO:0004663"(Rab geranylgeranyltransferase activity)|go:"GO:0005092"(GDP-dissociation inhibitor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005968"(Rab-protein geranylgeranyltransferase complex)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0007601"(visual perception)|go:"GO:0018344"(protein geranylgeranylation)|go:"GO:0031267"(small GTPase binding)|interpro:IPR001738("Rab escort (choroideraemia) protein")|interpro:IPR018203|interpro:IPR036188|reactome:R-HSA-6803205|reactome:R-HSA-8873719|reactome:R-HSA-8876198|go:"GO:0016192"(vesicle-mediated transport)|refseq:NP_001307888.1|refseq:NP_000381.1|refseq:NP_001138886.1 ensembl:ENSG00000136243(gene)|ensembl:ENST00000258742(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005049"(nuclear export signal receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0031965"(nuclear membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0051028"(mRNA transport)|interpro:IPR000571(Zinc finger, CCCH-type)|mint:O15504|rcsb pdb:6B4F|rcsb pdb:6B4I|rcsb pdb:6B4J|reactome:R-HSA-1169408|reactome:R-HSA-159227|reactome:R-HSA-159230|reactome:R-HSA-159231|reactome:R-HSA-159236|reactome:R-HSA-165054|reactome:R-HSA-168271|reactome:R-HSA-168276|reactome:R-HSA-168325|reactome:R-HSA-168333|reactome:R-HSA-170822|reactome:R-HSA-180746|reactome:R-HSA-180910|reactome:R-HSA-191859|reactome:R-HSA-3232142|reactome:R-HSA-3301854|reactome:R-HSA-3371453|reactome:R-HSA-4085377|reactome:R-HSA-4551638|reactome:R-HSA-4570464|reactome:R-HSA-4615885|reactome:R-HSA-5578749|reactome:R-HSA-5619107|reactome:R-HSA-6784531|reactome:R-HSA-9609690|reactome:R-HSA-9610379|reactome:R-HSA-3108214|refseq:NP_031368.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/07/08 rogid:lLHJ/D4ljKMp+kSHMHu9RUTdcps9606 rogid:31NO/6++LYM1UsI/mSVr0bsM1to9606 intact-crc:02E62AA95A194E51|rigid:OZZTjyWFxESXZbq4Dy5CU5tDT8c false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P24386 uniprotkb:P35658 intact:EBI-2515129|ensembl:ENSP00000350386|uniprotkb:O43732|uniprotkb:A1L4D2 intact:EBI-1222270|uniprotkb:A6NFQ0|uniprotkb:Q15010|uniprotkb:Q3KQZ0|uniprotkb:Q5JUP7|uniprotkb:Q75R47|uniprotkb:Q86XD3|intact:EBI-2555216|ensembl:ENSP00000352400 psi-mi:rae1_human(display_long)|uniprotkb:CHM(gene name)|psi-mi:CHM(display_short)|uniprotkb:REP1(gene name synonym)|uniprotkb:TCD(gene name synonym)|uniprotkb:Rab escort protein 1(gene name synonym)|uniprotkb:TCD protein(gene name synonym)|uniprotkb:Choroideremia protein(gene name synonym) psi-mi:nu214_human(display_long)|uniprotkb:NUP214(gene name)|psi-mi:NUP214(display_short)|uniprotkb:CAIN(gene name synonym)|uniprotkb:CAN(gene name synonym)|uniprotkb:KIAA0023(gene name synonym)|uniprotkb:Nucleoporin Nup214(gene name synonym)|uniprotkb:214 kDa nucleoporin(gene name synonym)|uniprotkb:Protein CAN(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515120|imex:IM-12079-96 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000188419(gene)|ensembl:ENST00000357749(transcript)|go:"GO:0004663"(Rab geranylgeranyltransferase activity)|go:"GO:0005092"(GDP-dissociation inhibitor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005968"(Rab-protein geranylgeranyltransferase complex)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0007601"(visual perception)|go:"GO:0018344"(protein geranylgeranylation)|go:"GO:0031267"(small GTPase binding)|interpro:IPR001738("Rab escort (choroideraemia) protein")|interpro:IPR018203|interpro:IPR036188|reactome:R-HSA-6803205|reactome:R-HSA-8873719|reactome:R-HSA-8876198|go:"GO:0016192"(vesicle-mediated transport)|refseq:NP_001307888.1|refseq:NP_000381.1|refseq:NP_001138886.1 ensembl:ENSP00000352400|ensembl:ENST00000411637|ensembl:ENSP00000396576|refseq:NP_005076.3|refseq:NP_001305253.1|refseq:NP_001305254.1|dip:DIP-38367N|rcsb pdb:3FMP|rcsb pdb:5DIS|reactome:R-HSA-1169408|reactome:R-HSA-159227|reactome:R-HSA-159230|reactome:R-HSA-159231|reactome:R-HSA-159236|reactome:R-HSA-165054|reactome:R-HSA-168271|reactome:R-HSA-168276|reactome:R-HSA-168325|reactome:R-HSA-168333|reactome:R-HSA-170822|reactome:R-HSA-180746|reactome:R-HSA-180910|reactome:R-HSA-191859|reactome:R-HSA-3108214|reactome:R-HSA-3232142|reactome:R-HSA-3301854|reactome:R-HSA-3371453|reactome:R-HSA-4085377|reactome:R-HSA-450520|reactome:R-HSA-4551638|reactome:R-HSA-4570464|reactome:R-HSA-4615885|reactome:R-HSA-5578749|reactome:R-HSA-5619107|reactome:R-HSA-6784531|reactome:R-HSA-9609690|reactome:R-HSA-9610379|rcsb pdb:3FMO|ensembl:ENSG00000126883(gene)|ensembl:ENST00000359428(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005049"(nuclear export signal receptor activity)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006405"(RNA export from nucleus)|go:"GO:0006406"(mRNA export from nucleus)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0017056"(structural constituent of nuclear pore)|go:"GO:0046822"(regulation of nucleocytoplasmic transport)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:1990876"(cytoplasmic side of nuclear pore)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR026054|interpro:IPR041553|mint:P35658|rcsb pdb:2OIT|rcsb pdb:3FHC psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/07/08 rogid:lLHJ/D4ljKMp+kSHMHu9RUTdcps9606 rogid:cW7RIiR4uhQgXIaByMiW3niFtTo9606 intact-crc:02E62AA95A194E51|rigid:OZZTjyWFxESXZbq4Dy5CU5tDT8c false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P24386 uniprotkb:Q6PJI9 intact:EBI-2515129|ensembl:ENSP00000350386|uniprotkb:O43732|uniprotkb:A1L4D2 intact:EBI-2515073|intact:EBI-28967178|ensembl:ENSP00000262144|uniprotkb:Q9HA43|uniprotkb:Q96PW5|uniprotkb:B3KRC3|uniprotkb:Q9BSW6|uniprotkb:Q71RE7 psi-mi:rae1_human(display_long)|uniprotkb:CHM(gene name)|psi-mi:CHM(display_short)|uniprotkb:REP1(gene name synonym)|uniprotkb:TCD(gene name synonym)|uniprotkb:Rab escort protein 1(gene name synonym)|uniprotkb:TCD protein(gene name synonym)|uniprotkb:Choroideremia protein(gene name synonym) psi-mi:wdr59_human(display_long)|uniprotkb:WDR59(gene name)|psi-mi:WDR59(display_short)|uniprotkb:KIAA1923(gene name synonym)|uniprotkb:WD repeat-containing protein 59(gene name synonym)|uniprotkb:FP977(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515120|imex:IM-12079-96 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000188419(gene)|ensembl:ENST00000357749(transcript)|go:"GO:0004663"(Rab geranylgeranyltransferase activity)|go:"GO:0005092"(GDP-dissociation inhibitor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005968"(Rab-protein geranylgeranyltransferase complex)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0007601"(visual perception)|go:"GO:0018344"(protein geranylgeranylation)|go:"GO:0031267"(small GTPase binding)|interpro:IPR001738("Rab escort (choroideraemia) protein")|interpro:IPR018203|interpro:IPR036188|reactome:R-HSA-6803205|reactome:R-HSA-8873719|reactome:R-HSA-8876198|go:"GO:0016192"(vesicle-mediated transport)|refseq:NP_001307888.1|refseq:NP_000381.1|refseq:NP_001138886.1 ensembl:ENSP00000262144|ensembl:ENST00000616369|ensembl:ENSP00000482446|ensembl:ENSG00000103091(gene)|ensembl:ENST00000262144(transcript)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0061700"(GATOR2 complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR006575(RWD)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR019775|interpro:IPR036322|interpro:IPR039456|reactome:R-HSA-9639288|mint:Q6PJI9|refseq:NP_001311100.1|refseq:NP_085058.3 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/07/08 rogid:lLHJ/D4ljKMp+kSHMHu9RUTdcps9606 rogid:7yMOhbv8kjVuL8I+Zs+8fLF933k9606 intact-crc:02E62AA95A194E51|rigid:OZZTjyWFxESXZbq4Dy5CU5tDT8c false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P24386 uniprotkb:O75592 intact:EBI-2515129|ensembl:ENSP00000350386|uniprotkb:O43732|uniprotkb:A1L4D2 intact:EBI-1043774|uniprotkb:Q5JSX8|uniprotkb:Q5VZN6|uniprotkb:Q6PIB6|uniprotkb:Q9UQ11|uniprotkb:Q9Y6E4|uniprotkb:A6NJC6|ensembl:ENSP00000444596 psi-mi:rae1_human(display_long)|uniprotkb:CHM(gene name)|psi-mi:CHM(display_short)|uniprotkb:REP1(gene name synonym)|uniprotkb:TCD(gene name synonym)|uniprotkb:Rab escort protein 1(gene name synonym)|uniprotkb:TCD protein(gene name synonym)|uniprotkb:Choroideremia protein(gene name synonym) psi-mi:mycb2_human(display_long)|uniprotkb:MYCBP2(gene name)|psi-mi:MYCBP2(display_short)|uniprotkb:KIAA0916(gene name synonym)|uniprotkb:PAM(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515120|imex:IM-12079-96 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000188419(gene)|ensembl:ENST00000357749(transcript)|go:"GO:0004663"(Rab geranylgeranyltransferase activity)|go:"GO:0005092"(GDP-dissociation inhibitor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005968"(Rab-protein geranylgeranyltransferase complex)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0007601"(visual perception)|go:"GO:0018344"(protein geranylgeranylation)|go:"GO:0031267"(small GTPase binding)|interpro:IPR001738("Rab escort (choroideraemia) protein")|interpro:IPR018203|interpro:IPR036188|reactome:R-HSA-6803205|reactome:R-HSA-8873719|reactome:R-HSA-8876198|go:"GO:0016192"(vesicle-mediated transport)|refseq:NP_001307888.1|refseq:NP_000381.1|refseq:NP_001138886.1 refseq:NP_055872.4|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003646(Bacterial SH3-like region)|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR008979(Galactose-binding like)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR012983(PHR)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017868|interpro:IPR038648|mint:O75592|rcsb pdb:5O6C|rcsb pdb:6T7F|ensembl:ENSG00000005810(gene)|ensembl:ENST00000544440(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|dip:DIP-28142N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/07/08 rogid:lLHJ/D4ljKMp+kSHMHu9RUTdcps9606 rogid:AR3FR/zd48HkVinEfdT17ItGkbU9606 intact-crc:02E62AA95A194E51|rigid:OZZTjyWFxESXZbq4Dy5CU5tDT8c false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P24386 uniprotkb:Q8IWA0 intact:EBI-2515129|ensembl:ENSP00000350386|uniprotkb:O43732|uniprotkb:A1L4D2 intact:EBI-2515097|ensembl:ENSP00000314193|uniprotkb:Q9UIX2|uniprotkb:Q9H9U5|uniprotkb:Q96J10|uniprotkb:Q9H8U8|uniprotkb:Q9H9V8 psi-mi:rae1_human(display_long)|uniprotkb:CHM(gene name)|psi-mi:CHM(display_short)|uniprotkb:REP1(gene name synonym)|uniprotkb:TCD(gene name synonym)|uniprotkb:Rab escort protein 1(gene name synonym)|uniprotkb:TCD protein(gene name synonym)|uniprotkb:Choroideremia protein(gene name synonym) psi-mi:wdr75_human(display_long)|uniprotkb:WDR75(gene name)|psi-mi:WDR75(display_short)|uniprotkb:UTP17(gene name synonym)|uniprotkb:U3 small nucleolar RNA-associated protein 17 homolog(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515120|imex:IM-12079-96 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000188419(gene)|ensembl:ENST00000357749(transcript)|go:"GO:0004663"(Rab geranylgeranyltransferase activity)|go:"GO:0005092"(GDP-dissociation inhibitor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005968"(Rab-protein geranylgeranyltransferase complex)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0007601"(visual perception)|go:"GO:0018344"(protein geranylgeranylation)|go:"GO:0031267"(small GTPase binding)|interpro:IPR001738("Rab escort (choroideraemia) protein")|interpro:IPR018203|interpro:IPR036188|reactome:R-HSA-6803205|reactome:R-HSA-8873719|reactome:R-HSA-8876198|go:"GO:0016192"(vesicle-mediated transport)|refseq:NP_001307888.1|refseq:NP_000381.1|refseq:NP_001138886.1 ensembl:ENSG00000115368(gene)|ensembl:ENST00000314761(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006364"(rRNA processing)|go:"GO:0045943"(positive regulation of transcription by RNA polymerase I)|go:"GO:2000234"(positive regulation of rRNA processing)|interpro:IPR001680(WD40 repeat)|interpro:IPR011047(Quinonprotein alcohol dehydrogenase-like)|interpro:IPR015943(WD40/YVTN repeat-like)|reactome:R-HSA-6790901|reactome:R-HSA-6791226|refseq:NP_115544.1|refseq:NP_001290025.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/07/08 rogid:lLHJ/D4ljKMp+kSHMHu9RUTdcps9606 rogid:qAYPzmryYALOzvea97t1q/NCsVs9606 intact-crc:02E62AA95A194E51|rigid:OZZTjyWFxESXZbq4Dy5CU5tDT8c false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P24386 uniprotkb:Q7L5N1 intact:EBI-2515129|ensembl:ENSP00000350386|uniprotkb:O43732|uniprotkb:A1L4D2 intact:EBI-486838|uniprotkb:O15387|uniprotkb:A4D2A3|ensembl:ENSP00000304102 psi-mi:rae1_human(display_long)|uniprotkb:CHM(gene name)|psi-mi:CHM(display_short)|uniprotkb:REP1(gene name synonym)|uniprotkb:TCD(gene name synonym)|uniprotkb:Rab escort protein 1(gene name synonym)|uniprotkb:TCD protein(gene name synonym)|uniprotkb:Choroideremia protein(gene name synonym) psi-mi:csn6_human(display_long)|uniprotkb:COPS6(gene name)|psi-mi:COPS6(display_short)|uniprotkb:CSN6(gene name synonym)|uniprotkb:HVIP(gene name synonym)|uniprotkb:JAB1-containing signalosome subunit 6(gene name synonym)|uniprotkb:Vpr-interacting protein(gene name synonym)|uniprotkb:MOV34 homolog(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515120|imex:IM-12079-96 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000188419(gene)|ensembl:ENST00000357749(transcript)|go:"GO:0004663"(Rab geranylgeranyltransferase activity)|go:"GO:0005092"(GDP-dissociation inhibitor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005968"(Rab-protein geranylgeranyltransferase complex)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0007601"(visual perception)|go:"GO:0018344"(protein geranylgeranylation)|go:"GO:0031267"(small GTPase binding)|interpro:IPR001738("Rab escort (choroideraemia) protein")|interpro:IPR018203|interpro:IPR036188|reactome:R-HSA-6803205|reactome:R-HSA-8873719|reactome:R-HSA-8876198|go:"GO:0016192"(vesicle-mediated transport)|refseq:NP_001307888.1|refseq:NP_000381.1|refseq:NP_001138886.1 refseq:NP_006824.2|ensembl:ENSG00000168090(gene)|ensembl:ENST00000303904(transcript)|go:"GO:0000338"(protein deneddylation)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070122"(isopeptidase activity)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR033859|interpro:IPR024969|interpro:IPR037518|mint:Q7L5N1|rcsb pdb:4D10|rcsb pdb:4D18|rcsb pdb:4QFT|rcsb pdb:4R14|rcsb pdb:4WSN|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|reactome:R-HSA-5696394|reactome:R-HSA-6781823|reactome:R-HSA-8856825|reactome:R-HSA-8951664|dip:DIP-32655N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/07/08 rogid:lLHJ/D4ljKMp+kSHMHu9RUTdcps9606 rogid:hyuYyAujJCJtbfS2tJ+UgH7jWP89606 intact-crc:02E62AA95A194E51|rigid:OZZTjyWFxESXZbq4Dy5CU5tDT8c false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P24386 uniprotkb:Q15428 intact:EBI-2515129|ensembl:ENSP00000350386|uniprotkb:O43732|uniprotkb:A1L4D2 intact:EBI-2462271|uniprotkb:O75245|uniprotkb:B2RBU1|uniprotkb:D6W605|intact:EBI-28985293|ensembl:ENSP00000221494 psi-mi:rae1_human(display_long)|uniprotkb:CHM(gene name)|psi-mi:CHM(display_short)|uniprotkb:REP1(gene name synonym)|uniprotkb:TCD(gene name synonym)|uniprotkb:Rab escort protein 1(gene name synonym)|uniprotkb:TCD protein(gene name synonym)|uniprotkb:Choroideremia protein(gene name synonym) psi-mi:sf3a2_human(display_long)|uniprotkb:SF3A2(gene name)|psi-mi:SF3A2(display_short)|uniprotkb:SAP62(gene name synonym)|uniprotkb:Spliceosome-associated protein 62(gene name synonym)|uniprotkb:SF3a66(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515120|imex:IM-12079-96 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000188419(gene)|ensembl:ENST00000357749(transcript)|go:"GO:0004663"(Rab geranylgeranyltransferase activity)|go:"GO:0005092"(GDP-dissociation inhibitor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005968"(Rab-protein geranylgeranyltransferase complex)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0007601"(visual perception)|go:"GO:0018344"(protein geranylgeranylation)|go:"GO:0031267"(small GTPase binding)|interpro:IPR001738("Rab escort (choroideraemia) protein")|interpro:IPR018203|interpro:IPR036188|reactome:R-HSA-6803205|reactome:R-HSA-8873719|reactome:R-HSA-8876198|go:"GO:0016192"(vesicle-mediated transport)|refseq:NP_001307888.1|refseq:NP_000381.1|refseq:NP_001138886.1 refseq:NP_009096.2|ensembl:ENSP00000221494|dip:DIP-42521N|ensembl:ENSG00000104897(gene)|ensembl:ENST00000221494(transcript)|go:"GO:0000245"(spliceosomal complex assembly)|go:"GO:0000389"(mRNA 3'-splice site recognition)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005686"(U2 snRNP)|go:"GO:0006397"(mRNA processing)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016607"(nuclear speck)|go:"GO:0071004"(U2-type prespliceosome)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:1903241"(U2-type prespliceosome assembly)|interpro:IPR000690(Zinc finger, C2H2-type matrin)|interpro:IPR003604(Zinc finger, U1-type)|interpro:IPR031781|interpro:IPR036236|mint:Q15428|rcsb pdb:5Z56|rcsb pdb:5Z57|rcsb pdb:5Z58|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6FF4|rcsb pdb:6FF7|rcsb pdb:6QX9|rcsb pdb:6Y53|rcsb pdb:6Y5Q|rcsb pdb:7ABG|rcsb pdb:7ABH|rcsb pdb:7ABI|reactome:R-HSA-72163 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/07/08 rogid:lLHJ/D4ljKMp+kSHMHu9RUTdcps9606 rogid:ME4xzpqT37HjPl/xy683FS1Vns89606 intact-crc:02E62AA95A194E51|rigid:OZZTjyWFxESXZbq4Dy5CU5tDT8c false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P24386 uniprotkb:Q15459 intact:EBI-2515129|ensembl:ENSP00000350386|uniprotkb:O43732|uniprotkb:A1L4D2 intact:EBI-1054743|uniprotkb:E9PAW1|ensembl:ENSP00000215793 psi-mi:rae1_human(display_long)|uniprotkb:CHM(gene name)|psi-mi:CHM(display_short)|uniprotkb:REP1(gene name synonym)|uniprotkb:TCD(gene name synonym)|uniprotkb:Rab escort protein 1(gene name synonym)|uniprotkb:TCD protein(gene name synonym)|uniprotkb:Choroideremia protein(gene name synonym) psi-mi:sf3a1_human(display_long)|uniprotkb:Spliceosome-associated protein 114(gene name synonym)|uniprotkb:SF3a120(gene name synonym)|uniprotkb:SF3A1(gene name)|psi-mi:SF3A1(display_short)|uniprotkb:SAP114(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515120|imex:IM-12079-96 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000188419(gene)|ensembl:ENST00000357749(transcript)|go:"GO:0004663"(Rab geranylgeranyltransferase activity)|go:"GO:0005092"(GDP-dissociation inhibitor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005968"(Rab-protein geranylgeranyltransferase complex)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0007601"(visual perception)|go:"GO:0018344"(protein geranylgeranylation)|go:"GO:0031267"(small GTPase binding)|interpro:IPR001738("Rab escort (choroideraemia) protein")|interpro:IPR018203|interpro:IPR036188|reactome:R-HSA-6803205|reactome:R-HSA-8873719|reactome:R-HSA-8876198|go:"GO:0016192"(vesicle-mediated transport)|refseq:NP_001307888.1|refseq:NP_000381.1|refseq:NP_001138886.1 refseq:NP_005868.1|ensembl:ENSG00000099995(gene)|ensembl:ENST00000215793(transcript)|go:"GO:0000389"(mRNA 3'-splice site recognition)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005684"(U2-type spliceosomal complex)|go:"GO:0005686"(U2 snRNP)|go:"GO:0006397"(mRNA processing)|go:"GO:0016607"(nuclear speck)|rcsb pdb:2DT6|go:"GO:0071004"(U2-type prespliceosome)|rcsb pdb:2DT7|rcsb pdb:5Z56|rcsb pdb:5Z57|rcsb pdb:5Z58|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6FF7|rcsb pdb:6QX9|go:"GO:0071005"(U2-type precatalytic spliceosome)|rcsb pdb:6Y53|rcsb pdb:6Y5Q|rcsb pdb:7ABG|rcsb pdb:7ABI|reactome:R-HSA-72163|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:1903241"(U2-type prespliceosome assembly)|interpro:IPR000061(SWAP/Surp)|interpro:IPR000626(Ubiquitin)|interpro:IPR022030|interpro:IPR029071|interpro:IPR035563|interpro:IPR035967|mint:Q15459|rcsb pdb:1ZKH|dip:DIP-29164N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/07/08 rogid:lLHJ/D4ljKMp+kSHMHu9RUTdcps9606 rogid:YrIs3RwfjUcDsHCJDgTLMnOUJZM9606 intact-crc:02E62AA95A194E51|rigid:OZZTjyWFxESXZbq4Dy5CU5tDT8c false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P24386 uniprotkb:Q9H7D7 intact:EBI-2515129|ensembl:ENSP00000350386|uniprotkb:O43732|uniprotkb:A1L4D2 intact:EBI-1046864|uniprotkb:A0MNN3|uniprotkb:Q4G100|uniprotkb:Q59EC4|uniprotkb:Q5GLZ9|uniprotkb:Q86UY4|uniprotkb:Q9H3C2|ensembl:ENSP00000504428|intact:EBI-1642504 psi-mi:rae1_human(display_long)|uniprotkb:CHM(gene name)|psi-mi:CHM(display_short)|uniprotkb:REP1(gene name synonym)|uniprotkb:TCD(gene name synonym)|uniprotkb:Rab escort protein 1(gene name synonym)|uniprotkb:TCD protein(gene name synonym)|uniprotkb:Choroideremia protein(gene name synonym) psi-mi:wdr26_human(display_long)|uniprotkb:CUL4- and DDB1-associated WDR protein 2(gene name synonym)|uniprotkb:Myocardial ischemic preconditioning up-regulated protein 2(gene name synonym)|uniprotkb:WDR26(gene name)|psi-mi:WDR26(display_short)|uniprotkb:CDW2(gene name synonym)|uniprotkb:MIP2(gene name synonym)|uniprotkb:PRO0852(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515120|imex:IM-12079-96 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000188419(gene)|ensembl:ENST00000357749(transcript)|go:"GO:0004663"(Rab geranylgeranyltransferase activity)|go:"GO:0005092"(GDP-dissociation inhibitor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005968"(Rab-protein geranylgeranyltransferase complex)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0007601"(visual perception)|go:"GO:0018344"(protein geranylgeranylation)|go:"GO:0031267"(small GTPase binding)|interpro:IPR001738("Rab escort (choroideraemia) protein")|interpro:IPR018203|interpro:IPR036188|reactome:R-HSA-6803205|reactome:R-HSA-8873719|reactome:R-HSA-8876198|go:"GO:0016192"(vesicle-mediated transport)|refseq:NP_001307888.1|refseq:NP_000381.1|refseq:NP_001138886.1 go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|interpro:IPR001680(WD40 repeat)|interpro:IPR006594(LisH dimerisation motif)|interpro:IPR006595(CTLH, C-terminal to LisH motif)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR036322|mint:Q9H7D7|ensembl:ENSG00000162923(gene)|ensembl:ENST00000678917(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0005634"(nucleus)|refseq:NP_001108585.2|refseq:NP_079436.4 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/07/08 rogid:lLHJ/D4ljKMp+kSHMHu9RUTdcps9606 rogid:HRA6f68aldUqB1rVa7uM9srSyR49606 intact-crc:02E62AA95A194E51|rigid:OZZTjyWFxESXZbq4Dy5CU5tDT8c false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P24386 uniprotkb:Q9NW08 intact:EBI-2515129|ensembl:ENSP00000350386|uniprotkb:O43732|uniprotkb:A1L4D2 intact:EBI-2515106|uniprotkb:A8K6H0|uniprotkb:Q9NW59|uniprotkb:B3KV73|uniprotkb:F5H1E6|ensembl:ENSP00000228347 psi-mi:rae1_human(display_long)|uniprotkb:CHM(gene name)|psi-mi:CHM(display_short)|uniprotkb:REP1(gene name synonym)|uniprotkb:TCD(gene name synonym)|uniprotkb:Rab escort protein 1(gene name synonym)|uniprotkb:TCD protein(gene name synonym)|uniprotkb:Choroideremia protein(gene name synonym) psi-mi:rpc2_human(display_long)|uniprotkb:POLR3B(gene name)|psi-mi:POLR3B(display_short)|uniprotkb:DNA-directed RNA polymerase III subunit B(gene name synonym)|uniprotkb:DNA-directed RNA polymerase III 127.6 kDa polypeptide(gene name synonym)|uniprotkb:C128(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515120|imex:IM-12079-96 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000188419(gene)|ensembl:ENST00000357749(transcript)|go:"GO:0004663"(Rab geranylgeranyltransferase activity)|go:"GO:0005092"(GDP-dissociation inhibitor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005968"(Rab-protein geranylgeranyltransferase complex)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0007601"(visual perception)|go:"GO:0018344"(protein geranylgeranylation)|go:"GO:0031267"(small GTPase binding)|interpro:IPR001738("Rab escort (choroideraemia) protein")|interpro:IPR018203|interpro:IPR036188|reactome:R-HSA-6803205|reactome:R-HSA-8873719|reactome:R-HSA-8876198|go:"GO:0016192"(vesicle-mediated transport)|refseq:NP_001307888.1|refseq:NP_000381.1|refseq:NP_001138886.1 refseq:NP_060552.4|refseq:NP_001154180.1|ensembl:ENSG00000013503(gene)|ensembl:ENST00000228347(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003899"(DNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005666"(RNA polymerase III complex)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0032549"(ribonucleoside binding)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0045087"(innate immune response)|go:"GO:0045089"(positive regulation of innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0051607"(defense response to virus)|interpro:IPR007120(DNA-directed RNA polymerase, subunit 2, domain 6)|interpro:IPR007121(RNA polymerase, beta subunit, conserved site)|interpro:IPR007641(RNA polymerase Rpb2, domain 7)|interpro:IPR007642(RNA polymerase Rpb2, domain 2)|interpro:IPR007644(RNA polymerase, beta subunit, protrusion)|interpro:IPR007645(RNA polymerase Rpb2, domain 3)|interpro:IPR007646(RNA polymerase Rpb2, domain 4)|interpro:IPR007647(RNA polymerase Rpb2, domain 5)|interpro:IPR014724(RNA polymerase Rpb2, OB-fold)|interpro:IPR015712(DNA-directed RNA polymerase, subunit 2)|interpro:IPR037033|mint:Q9NW08|rcsb pdb:7A6H|rcsb pdb:7AE1|rcsb pdb:7AE3|rcsb pdb:7AEA|rcsb pdb:7AST|rcsb pdb:7D58|rcsb pdb:7D59|rcsb pdb:7DN3|rcsb pdb:7DU2|reactome:R-HSA-1834949|reactome:R-HSA-73780|reactome:R-HSA-73980|reactome:R-HSA-749476|reactome:R-HSA-76061|reactome:R-HSA-76066|reactome:R-HSA-76071 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/07/08 rogid:lLHJ/D4ljKMp+kSHMHu9RUTdcps9606 rogid:wHQRBDeUbMtfpXmUd/LkiE6GNaM9606 intact-crc:02E62AA95A194E51|rigid:OZZTjyWFxESXZbq4Dy5CU5tDT8c false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P24386 uniprotkb:Q9UMR2 intact:EBI-2515129|ensembl:ENSP00000350386|uniprotkb:O43732|uniprotkb:A1L4D2 intact:EBI-719232|uniprotkb:Q6FIB7|uniprotkb:Q6IAE0|uniprotkb:Q9H0U0|uniprotkb:B3KNE9|ensembl:ENSP00000288071|uniprotkb:Q96KE7|uniprotkb:B4DXS6|uniprotkb:E7EMK4 psi-mi:rae1_human(display_long)|uniprotkb:CHM(gene name)|psi-mi:CHM(display_short)|uniprotkb:REP1(gene name synonym)|uniprotkb:TCD(gene name synonym)|uniprotkb:Rab escort protein 1(gene name synonym)|uniprotkb:TCD protein(gene name synonym)|uniprotkb:Choroideremia protein(gene name synonym) psi-mi:dd19b_human(display_long)|uniprotkb:DEAD box protein 19B(gene name synonym)|uniprotkb:DEAD box RNA helicase DEAD5(gene name synonym)|uniprotkb:DDX19B(gene name)|psi-mi:DDX19B(display_short)|uniprotkb:DBP5(gene name synonym)|uniprotkb:DDX19(gene name synonym)|uniprotkb:TDBP(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515120|imex:IM-12079-96 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000188419(gene)|ensembl:ENST00000357749(transcript)|go:"GO:0004663"(Rab geranylgeranyltransferase activity)|go:"GO:0005092"(GDP-dissociation inhibitor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005968"(Rab-protein geranylgeranyltransferase complex)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0007601"(visual perception)|go:"GO:0018344"(protein geranylgeranylation)|go:"GO:0031267"(small GTPase binding)|interpro:IPR001738("Rab escort (choroideraemia) protein")|interpro:IPR018203|interpro:IPR036188|reactome:R-HSA-6803205|reactome:R-HSA-8873719|reactome:R-HSA-8876198|go:"GO:0016192"(vesicle-mediated transport)|refseq:NP_001307888.1|refseq:NP_000381.1|refseq:NP_001138886.1 refseq:NP_001014449.1|refseq:NP_001014451.1|refseq:NP_009173.1|ensembl:ENSG00000157349(gene)|ensembl:ENST00000288071(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0004386"(helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005643"(nuclear pore)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|rcsb pdb:3EWS|rcsb pdb:3FHC|rcsb pdb:3FHT|rcsb pdb:3FMO|rcsb pdb:3FMP|rcsb pdb:3G0H|rcsb pdb:6B4I|rcsb pdb:6B4J|rcsb pdb:6B4K|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006406"(mRNA export from nucleus)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016020"(membrane)|go:"GO:0016973"("poly(A)+ mRNA export from nucleus")|go:"GO:0070062"(extracellular exosome)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|refseq:NP_001244102.1|refseq:NP_001244103.1|refseq:NP_001244101.1|dip:DIP-48486N|refseq:XP_006721190.1|refseq:XP_016878379.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/07/08 rogid:lLHJ/D4ljKMp+kSHMHu9RUTdcps9606 rogid:1UiDyTWXtMNt5s6Dw86KD1xY+0o9606 intact-crc:02E62AA95A194E51|rigid:OZZTjyWFxESXZbq4Dy5CU5tDT8c false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P24386 uniprotkb:Q2TAY7 intact:EBI-2515129|ensembl:ENSP00000350386|uniprotkb:O43732|uniprotkb:A1L4D2 intact:EBI-298027|uniprotkb:Q9BU59|uniprotkb:Q9HA96|uniprotkb:Q9NVD1|ensembl:ENSP00000380336|uniprotkb:B4E3L0 psi-mi:rae1_human(display_long)|uniprotkb:CHM(gene name)|psi-mi:CHM(display_short)|uniprotkb:REP1(gene name synonym)|uniprotkb:TCD(gene name synonym)|uniprotkb:Rab escort protein 1(gene name synonym)|uniprotkb:TCD protein(gene name synonym)|uniprotkb:Choroideremia protein(gene name synonym) psi-mi:smu1_human(display_long)|uniprotkb:Smu-1 suppressor of mec-8 and unc-52 protein homolog(gene name synonym)|uniprotkb:SMU1(gene name)|psi-mi:SMU1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515120|imex:IM-12079-96 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000188419(gene)|ensembl:ENST00000357749(transcript)|go:"GO:0004663"(Rab geranylgeranyltransferase activity)|go:"GO:0005092"(GDP-dissociation inhibitor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005968"(Rab-protein geranylgeranyltransferase complex)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0007601"(visual perception)|go:"GO:0018344"(protein geranylgeranylation)|go:"GO:0031267"(small GTPase binding)|interpro:IPR001738("Rab escort (choroideraemia) protein")|interpro:IPR018203|interpro:IPR036188|reactome:R-HSA-6803205|reactome:R-HSA-8873719|reactome:R-HSA-8876198|go:"GO:0016192"(vesicle-mediated transport)|refseq:NP_001307888.1|refseq:NP_000381.1|refseq:NP_001138886.1 ensembl:ENST00000397149(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0008380"(RNA splicing)|go:"GO:0016607"(nuclear speck)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071011"(precatalytic spliceosome)|interpro:IPR001680(WD40 repeat)|interpro:IPR006594(LisH dimerisation motif)|interpro:IPR006595(CTLH, C-terminal to LisH motif)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|mint:Q2TAY7|rcsb pdb:5O9Z|rcsb pdb:6AHD|rcsb pdb:6Q8F|rcsb pdb:6Q8I|rcsb pdb:6Q8J|ensembl:ENSG00000122692(gene)|refseq:NP_060695.2 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/07/08 rogid:lLHJ/D4ljKMp+kSHMHu9RUTdcps9606 rogid:zbTRfKynNIUSFY8IEqyYWh3JSho9606 intact-crc:02E62AA95A194E51|rigid:OZZTjyWFxESXZbq4Dy5CU5tDT8c false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P24386 uniprotkb:Q99567 intact:EBI-2515129|ensembl:ENSP00000350386|uniprotkb:O43732|uniprotkb:A1L4D2 intact:EBI-726178|uniprotkb:Q9BWE5|uniprotkb:D3DTM2|intact:EBI-28967918|ensembl:ENSP00000458954 psi-mi:rae1_human(display_long)|uniprotkb:CHM(gene name)|psi-mi:CHM(display_short)|uniprotkb:REP1(gene name synonym)|uniprotkb:TCD(gene name synonym)|uniprotkb:Rab escort protein 1(gene name synonym)|uniprotkb:TCD protein(gene name synonym)|uniprotkb:Choroideremia protein(gene name synonym) psi-mi:nup88_human(display_long)|uniprotkb:Nucleoporin Nup88(gene name synonym)|uniprotkb:88 kDa nucleoporin(gene name synonym)|uniprotkb:NUP88(gene name)|psi-mi:NUP88(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515120|imex:IM-12079-96 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000188419(gene)|ensembl:ENST00000357749(transcript)|go:"GO:0004663"(Rab geranylgeranyltransferase activity)|go:"GO:0005092"(GDP-dissociation inhibitor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005968"(Rab-protein geranylgeranyltransferase complex)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0007601"(visual perception)|go:"GO:0018344"(protein geranylgeranylation)|go:"GO:0031267"(small GTPase binding)|interpro:IPR001738("Rab escort (choroideraemia) protein")|interpro:IPR018203|interpro:IPR036188|reactome:R-HSA-6803205|reactome:R-HSA-8873719|reactome:R-HSA-8876198|go:"GO:0016192"(vesicle-mediated transport)|refseq:NP_001307888.1|refseq:NP_000381.1|refseq:NP_001138886.1 ensembl:ENSP00000458954|refseq:NP_002523.2|refseq:NP_001307582.1|ensembl:ENSG00000108559(gene)|ensembl:ENST00000573584(transcript)|go:"GO:0000055"(ribosomal large subunit export from nucleus)|go:"GO:0000056"(ribosomal small subunit export from nucleus)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005215"(transporter activity)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006406"(mRNA export from nucleus)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0017056"(structural constituent of nuclear pore)|interpro:IPR019321|interpro:IPR037700|mint:Q99567|reactome:R-HSA-1169408|reactome:R-HSA-159227|reactome:R-HSA-159230|reactome:R-HSA-159231|reactome:R-HSA-159236|reactome:R-HSA-165054|reactome:R-HSA-168271|reactome:R-HSA-168276|reactome:R-HSA-168325|reactome:R-HSA-168333|reactome:R-HSA-170822|reactome:R-HSA-180746|reactome:R-HSA-180910|reactome:R-HSA-191859|reactome:R-HSA-3108214|reactome:R-HSA-3232142|reactome:R-HSA-3301854|reactome:R-HSA-3371453|reactome:R-HSA-4085377|reactome:R-HSA-4551638|reactome:R-HSA-4570464|reactome:R-HSA-4615885|reactome:R-HSA-5578749|reactome:R-HSA-5619107|reactome:R-HSA-6784531|reactome:R-HSA-9609690|reactome:R-HSA-9610379 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/07/08 rogid:lLHJ/D4ljKMp+kSHMHu9RUTdcps9606 rogid:4e7YTurNWkXUn9zj0JiD2muc94A9606 intact-crc:02E62AA95A194E51|rigid:OZZTjyWFxESXZbq4Dy5CU5tDT8c false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P24386 uniprotkb:Q8N302 intact:EBI-2515129|ensembl:ENSP00000350386|uniprotkb:O43732|uniprotkb:A1L4D2 intact:EBI-747899|ensembl:ENSP00000316109|uniprotkb:O00581|uniprotkb:Q53YS3|uniprotkb:Q9BU84|uniprotkb:Q9NW66|intact:EBI-28984369 psi-mi:rae1_human(display_long)|uniprotkb:CHM(gene name)|psi-mi:CHM(display_short)|uniprotkb:REP1(gene name synonym)|uniprotkb:TCD(gene name synonym)|uniprotkb:Rab escort protein 1(gene name synonym)|uniprotkb:TCD protein(gene name synonym)|uniprotkb:Choroideremia protein(gene name synonym) psi-mi:aggf1_human(display_long)|uniprotkb:Angiogenic factor VG5Q(gene name synonym)|uniprotkb:Vasculogenesis gene on 5q protein(gene name synonym)|uniprotkb:G patch domain-containing protein 7(gene name synonym)|uniprotkb:AGGF1(gene name)|psi-mi:AGGF1(display_short)|uniprotkb:VG5Q(gene name synonym)|uniprotkb:GPATC7(gene name synonym)|uniprotkb:GPATCH7(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515120|imex:IM-12079-96 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000188419(gene)|ensembl:ENST00000357749(transcript)|go:"GO:0004663"(Rab geranylgeranyltransferase activity)|go:"GO:0005092"(GDP-dissociation inhibitor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005968"(Rab-protein geranylgeranyltransferase complex)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0007601"(visual perception)|go:"GO:0018344"(protein geranylgeranylation)|go:"GO:0031267"(small GTPase binding)|interpro:IPR001738("Rab escort (choroideraemia) protein")|interpro:IPR018203|interpro:IPR036188|reactome:R-HSA-6803205|reactome:R-HSA-8873719|reactome:R-HSA-8876198|go:"GO:0016192"(vesicle-mediated transport)|refseq:NP_001307888.1|refseq:NP_000381.1|refseq:NP_001138886.1 ensembl:ENSG00000164252(gene)|ensembl:ENST00000312916(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0007155"(cell adhesion)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048471"(perinuclear region of cytoplasm)|interpro:IPR000253(Forkhead-associated)|interpro:IPR000467(D111/G-patch)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR035624|interpro:IPR041591|refseq:NP_060516.2|mint:Q8N302|reactome:R-HSA-6802952|ensembl:ENST00000506806|ensembl:ENSP00000424733|ensembl:ENSP00000316109 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/07/08 rogid:lLHJ/D4ljKMp+kSHMHu9RUTdcps9606 rogid:5FA3UwL9w6K00rccLnd3fwIs8oo9606 intact-crc:02E62AA95A194E51|rigid:OZZTjyWFxESXZbq4Dy5CU5tDT8c false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P24386 uniprotkb:O95260 intact:EBI-2515129|ensembl:ENSP00000350386|uniprotkb:O43732|uniprotkb:A1L4D2 intact:EBI-1043378|uniprotkb:O95261|uniprotkb:Q8WW04|ensembl:ENSP00000224652|uniprotkb:Q5SQQ3 psi-mi:rae1_human(display_long)|uniprotkb:CHM(gene name)|psi-mi:CHM(display_short)|uniprotkb:REP1(gene name synonym)|uniprotkb:TCD(gene name synonym)|uniprotkb:Rab escort protein 1(gene name synonym)|uniprotkb:TCD protein(gene name synonym)|uniprotkb:Choroideremia protein(gene name synonym) psi-mi:ate1_human(display_long)|uniprotkb:Arginine-tRNA--protein transferase 1(gene name synonym)|uniprotkb:ATE1(gene name)|psi-mi:ATE1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515120|imex:IM-12079-96 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000188419(gene)|ensembl:ENST00000357749(transcript)|go:"GO:0004663"(Rab geranylgeranyltransferase activity)|go:"GO:0005092"(GDP-dissociation inhibitor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005968"(Rab-protein geranylgeranyltransferase complex)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0007601"(visual perception)|go:"GO:0018344"(protein geranylgeranylation)|go:"GO:0031267"(small GTPase binding)|interpro:IPR001738("Rab escort (choroideraemia) protein")|interpro:IPR018203|interpro:IPR036188|reactome:R-HSA-6803205|reactome:R-HSA-8873719|reactome:R-HSA-8876198|go:"GO:0016192"(vesicle-mediated transport)|refseq:NP_001307888.1|refseq:NP_000381.1|refseq:NP_001138886.1 ensembl:ENSG00000107669(gene)|ensembl:ENST00000224652(transcript)|interpro:IPR007471(Arginine-tRNA-protein transferase, N-terminal)|interpro:IPR007472(Arginine-tRNA-protein transferase, C-terminal)|go:"GO:0004057"(arginyltransferase activity)|interpro:IPR016181(Acyl-CoA N-acyltransferase)|interpro:IPR017137(Arginine-tRNA--protein transferase 1, eukaryotic)|go:"GO:0005634"(nucleus)|interpro:IPR030700|mint:O95260|go:"GO:0005737"(cytoplasm)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0016598"(protein arginylation)|refseq:NP_001001976.1|refseq:NP_008972.2|refseq:NP_001275663.1|refseq:NP_001275664.1|refseq:NP_001275665.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/07/08 rogid:lLHJ/D4ljKMp+kSHMHu9RUTdcps9606 rogid:vK21nNxx2fa9ct7O5WG0LqtD9u09606 intact-crc:02E62AA95A194E51|rigid:OZZTjyWFxESXZbq4Dy5CU5tDT8c false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P24386 uniprotkb:Q8IUR7 intact:EBI-2515129|ensembl:ENSP00000350386|uniprotkb:O43732|uniprotkb:A1L4D2 intact:EBI-1049469|uniprotkb:Q6PIL2|uniprotkb:Q96D19|uniprotkb:Q96HZ5|uniprotkb:Q9NV02|uniprotkb:Q9NV94|uniprotkb:Q9Y4R9|uniprotkb:A8K0L2|uniprotkb:D3DNE6|uniprotkb:B7Z441|uniprotkb:B7Z453|uniprotkb:F5GWK4|ensembl:ENSP00000419413 psi-mi:rae1_human(display_long)|uniprotkb:CHM(gene name)|psi-mi:CHM(display_short)|uniprotkb:REP1(gene name synonym)|uniprotkb:TCD(gene name synonym)|uniprotkb:Rab escort protein 1(gene name synonym)|uniprotkb:TCD protein(gene name synonym)|uniprotkb:Choroideremia protein(gene name synonym) psi-mi:armc8_human(display_long)|uniprotkb:ARMC8(gene name)|psi-mi:ARMC8(display_short)|uniprotkb:S863-2(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515120|imex:IM-12079-96 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000188419(gene)|ensembl:ENST00000357749(transcript)|go:"GO:0004663"(Rab geranylgeranyltransferase activity)|go:"GO:0005092"(GDP-dissociation inhibitor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005968"(Rab-protein geranylgeranyltransferase complex)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0007601"(visual perception)|go:"GO:0018344"(protein geranylgeranylation)|go:"GO:0031267"(small GTPase binding)|interpro:IPR001738("Rab escort (choroideraemia) protein")|interpro:IPR018203|interpro:IPR036188|reactome:R-HSA-6803205|reactome:R-HSA-8873719|reactome:R-HSA-8876198|go:"GO:0016192"(vesicle-mediated transport)|refseq:NP_001307888.1|refseq:NP_000381.1|refseq:NP_001138886.1 refseq:NP_054873.2|refseq:NP_056211.2|refseq:NP_998819.1|refseq:XP_011510934.1|refseq:XP_011510935.1|refseq:NP_001253970.1|refseq:NP_001253971.1|refseq:NP_001269271.1|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0034657"(GID complex)|go:"GO:0035580"(specific granule lumen)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:1904724"(tertiary granule lumen)|interpro:IPR000225(Armadillo)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR038739|mint:Q8IUR7|rcsb pdb:7NSC|reactome:R-HSA-6798695|ensembl:ENSG00000114098(gene)|ensembl:ENST00000469044(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0005576"(extracellular region)|refseq:XP_006713627.1|refseq:XP_006713628.1|refseq:XP_006713629.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/07/08 rogid:lLHJ/D4ljKMp+kSHMHu9RUTdcps9606 rogid:9QXdCIwU8zeZ94oQ7JJNDVD2NDk9606 intact-crc:02E62AA95A194E51|rigid:OZZTjyWFxESXZbq4Dy5CU5tDT8c false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P24386 uniprotkb:Q5SRE5 intact:EBI-2515129|ensembl:ENSP00000350386|uniprotkb:O43732|uniprotkb:A1L4D2 intact:EBI-1049404|uniprotkb:Q14675|uniprotkb:Q2TA87|uniprotkb:Q7Z3K8|uniprotkb:Q8IWF1|intact:EBI-2555229|ensembl:ENSP00000361658 psi-mi:rae1_human(display_long)|uniprotkb:CHM(gene name)|psi-mi:CHM(display_short)|uniprotkb:REP1(gene name synonym)|uniprotkb:TCD(gene name synonym)|uniprotkb:Rab escort protein 1(gene name synonym)|uniprotkb:TCD protein(gene name synonym)|uniprotkb:Choroideremia protein(gene name synonym) psi-mi:nu188_human(display_long)|uniprotkb:NUP188(gene name)|psi-mi:NUP188(display_short)|uniprotkb:KIAA0169(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515120|imex:IM-12079-96 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000188419(gene)|ensembl:ENST00000357749(transcript)|go:"GO:0004663"(Rab geranylgeranyltransferase activity)|go:"GO:0005092"(GDP-dissociation inhibitor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005968"(Rab-protein geranylgeranyltransferase complex)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0007601"(visual perception)|go:"GO:0018344"(protein geranylgeranylation)|go:"GO:0031267"(small GTPase binding)|interpro:IPR001738("Rab escort (choroideraemia) protein")|interpro:IPR018203|interpro:IPR036188|reactome:R-HSA-6803205|reactome:R-HSA-8873719|reactome:R-HSA-8876198|go:"GO:0016192"(vesicle-mediated transport)|refseq:NP_001307888.1|refseq:NP_000381.1|refseq:NP_001138886.1 refseq:NP_056169.1|ensembl:ENSG00000095319(gene)|ensembl:ENST00000372577(transcript)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005829"(cytosol)|go:"GO:0006405"(RNA export from nucleus)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0016020"(membrane)|go:"GO:0017056"(structural constituent of nuclear pore)|go:"GO:0044611"(nuclear pore inner ring)|go:"GO:0051028"(mRNA transport)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018864|interpro:IPR044840|mint:Q5SRE5|rcsb pdb:5IJO|reactome:R-HSA-1169408|reactome:R-HSA-159227|reactome:R-HSA-159230|reactome:R-HSA-159231|reactome:R-HSA-159236|reactome:R-HSA-165054|reactome:R-HSA-168271|reactome:R-HSA-168276|reactome:R-HSA-168325|reactome:R-HSA-168333|reactome:R-HSA-170822|reactome:R-HSA-180746|reactome:R-HSA-180910|reactome:R-HSA-191859|reactome:R-HSA-3108214|reactome:R-HSA-3232142|reactome:R-HSA-3301854|reactome:R-HSA-3371453|reactome:R-HSA-4085377|reactome:R-HSA-4551638|reactome:R-HSA-4570464|reactome:R-HSA-4615885|reactome:R-HSA-5578749|reactome:R-HSA-5619107|reactome:R-HSA-6784531|reactome:R-HSA-9609690|reactome:R-HSA-9610379|reactome:R-HSA-9615933 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/07/08 rogid:lLHJ/D4ljKMp+kSHMHu9RUTdcps9606 rogid:eoj+tg9RAVKcVlT9ku1ozXCa3u89606 intact-crc:02E62AA95A194E51|rigid:OZZTjyWFxESXZbq4Dy5CU5tDT8c false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P24386 uniprotkb:P49642 intact:EBI-2515129|ensembl:ENSP00000350386|uniprotkb:O43732|uniprotkb:A1L4D2 intact:EBI-726050|ensembl:ENSP00000350491 psi-mi:rae1_human(display_long)|uniprotkb:CHM(gene name)|psi-mi:CHM(display_short)|uniprotkb:REP1(gene name synonym)|uniprotkb:TCD(gene name synonym)|uniprotkb:Rab escort protein 1(gene name synonym)|uniprotkb:TCD protein(gene name synonym)|uniprotkb:Choroideremia protein(gene name synonym) psi-mi:pri1_human(display_long)|uniprotkb:DNA primase 49 kDa subunit(gene name synonym)|uniprotkb:PRIM1(gene name)|psi-mi:PRIM1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515120|imex:IM-12079-96 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000188419(gene)|ensembl:ENST00000357749(transcript)|go:"GO:0004663"(Rab geranylgeranyltransferase activity)|go:"GO:0005092"(GDP-dissociation inhibitor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005968"(Rab-protein geranylgeranyltransferase complex)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0007601"(visual perception)|go:"GO:0018344"(protein geranylgeranylation)|go:"GO:0031267"(small GTPase binding)|interpro:IPR001738("Rab escort (choroideraemia) protein")|interpro:IPR018203|interpro:IPR036188|reactome:R-HSA-6803205|reactome:R-HSA-8873719|reactome:R-HSA-8876198|go:"GO:0016192"(vesicle-mediated transport)|refseq:NP_001307888.1|refseq:NP_000381.1|refseq:NP_001138886.1 ensembl:ENSG00000198056(gene)|interpro:IPR014052(DNA primase, small subunit, eukaryotic and archaeal)|refseq:NP_000937.1|rcsb pdb:4BPU|rcsb pdb:4BPW|ensembl:ENST00000338193(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0003896"(DNA primase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005658"("alpha DNA polymerase:primase complex")|go:"GO:0006269"(DNA replication, synthesis of RNA primer)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016020"(membrane)|go:"GO:0032553"(ribonucleotide binding)|rcsb pdb:4BPX|rcsb pdb:4LIK|interpro:IPR002755(DNA primase, small subunit)|rcsb pdb:4LIL|rcsb pdb:4MHQ|rcsb pdb:4RR2|rcsb pdb:5EXR|rcsb pdb:6R4S|rcsb pdb:6R4T|rcsb pdb:6R4U|rcsb pdb:6R5D|rcsb pdb:6R5E|rcsb pdb:6RB4|reactome:R-HSA-113501|reactome:R-HSA-174411|reactome:R-HSA-174430|reactome:R-HSA-68952|reactome:R-HSA-68962|reactome:R-HSA-69091|reactome:R-HSA-69166|reactome:R-HSA-69183|reactome:R-HSA-9710421 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/07/08 rogid:lLHJ/D4ljKMp+kSHMHu9RUTdcps9606 rogid:bgNj0hjvHPliBXVfkZmg7v0N/uw9606 intact-crc:02E62AA95A194E51|rigid:OZZTjyWFxESXZbq4Dy5CU5tDT8c false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P24386 uniprotkb:Q9NVU0 intact:EBI-2515129|ensembl:ENSP00000350386|uniprotkb:O43732|uniprotkb:A1L4D2 intact:EBI-2515048|ensembl:ENSP00000299853|ensembl:ENSP00000492514|ensembl:ENSP00000492263|uniprotkb:B4DL24|uniprotkb:Q9H8W8|uniprotkb:Q9H907|uniprotkb:Q9BWF7|uniprotkb:Q9P276|uniprotkb:B4DUP6|uniprotkb:H3BT11 psi-mi:rae1_human(display_long)|uniprotkb:CHM(gene name)|psi-mi:CHM(display_short)|uniprotkb:REP1(gene name synonym)|uniprotkb:TCD(gene name synonym)|uniprotkb:Rab escort protein 1(gene name synonym)|uniprotkb:TCD protein(gene name synonym)|uniprotkb:Choroideremia protein(gene name synonym) psi-mi:rpc5_human(display_long)|uniprotkb:POLR3E(gene name)|psi-mi:POLR3E(display_short)|uniprotkb:KIAA1452(gene name synonym)|uniprotkb:DNA-directed RNA polymerase III 80 kDa polypeptide(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515120|imex:IM-12079-96 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000188419(gene)|ensembl:ENST00000357749(transcript)|go:"GO:0004663"(Rab geranylgeranyltransferase activity)|go:"GO:0005092"(GDP-dissociation inhibitor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005968"(Rab-protein geranylgeranyltransferase complex)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0007601"(visual perception)|go:"GO:0018344"(protein geranylgeranylation)|go:"GO:0031267"(small GTPase binding)|interpro:IPR001738("Rab escort (choroideraemia) protein")|interpro:IPR018203|interpro:IPR036188|reactome:R-HSA-6803205|reactome:R-HSA-8873719|reactome:R-HSA-8876198|go:"GO:0016192"(vesicle-mediated transport)|refseq:NP_001307888.1|refseq:NP_000381.1|refseq:NP_001138886.1 ensembl:ENSG00000058600(gene)|ensembl:ENSG00000284282(gene)|ensembl:ENST00000299853(transcript)|ensembl:ENST00000639550(transcript)|ensembl:ENST00000640588(transcript)|go:"GO:0003899"(DNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005666"(RNA polymerase III complex)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0045087"(innate immune response)|go:"GO:0051607"(defense response to virus)|interpro:IPR006886(Sin-like protein conserved region)|mint:Q9NVU0|rcsb pdb:7A6H|rcsb pdb:7AE1|rcsb pdb:7AE3|rcsb pdb:7AEA|rcsb pdb:7AST|rcsb pdb:7ASU|rcsb pdb:7ASV|rcsb pdb:7D58|rcsb pdb:7D59|rcsb pdb:7DU2|reactome:R-HSA-1834949|reactome:R-HSA-73780|reactome:R-HSA-73980|reactome:R-HSA-749476|reactome:R-HSA-76061|reactome:R-HSA-76066|reactome:R-HSA-76071|rcsb pdb:7DN3|refseq:NP_060589.1|refseq:NP_001244964.1|refseq:NP_001244965.1|refseq:NP_001244962.1|refseq:NP_001244963.1|refseq:XP_006721126.1|refseq:XP_006726676.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/07/08 rogid:lLHJ/D4ljKMp+kSHMHu9RUTdcps9606 rogid:X4MAZK4RTaqr2QmPSRgaSnxD8zY9606 intact-crc:02E62AA95A194E51|rigid:OZZTjyWFxESXZbq4Dy5CU5tDT8c false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P24386 uniprotkb:Q07157 intact:EBI-2515129|ensembl:ENSP00000350386|uniprotkb:O43732|uniprotkb:A1L4D2 intact:EBI-79553|uniprotkb:B4E3K1|ensembl:ENSP00000281537|ensembl:ENSP00000484535|uniprotkb:Q2NKP3|uniprotkb:Q4ZGJ6 psi-mi:rae1_human(display_long)|uniprotkb:CHM(gene name)|psi-mi:CHM(display_short)|uniprotkb:REP1(gene name synonym)|uniprotkb:TCD(gene name synonym)|uniprotkb:Rab escort protein 1(gene name synonym)|uniprotkb:TCD protein(gene name synonym)|uniprotkb:Choroideremia protein(gene name synonym) psi-mi:zo1_human(display_long)|uniprotkb:TJP1(gene name)|psi-mi:TJP1(display_short)|uniprotkb:ZO1(gene name synonym)|uniprotkb:Zonula occludens protein 1(gene name synonym)|uniprotkb:Zona occludens protein 1(gene name synonym)|uniprotkb:Tight junction protein 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515120|imex:IM-12079-96 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000188419(gene)|ensembl:ENST00000357749(transcript)|go:"GO:0004663"(Rab geranylgeranyltransferase activity)|go:"GO:0005092"(GDP-dissociation inhibitor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005968"(Rab-protein geranylgeranyltransferase complex)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0007601"(visual perception)|go:"GO:0018344"(protein geranylgeranylation)|go:"GO:0031267"(small GTPase binding)|interpro:IPR001738("Rab escort (choroideraemia) protein")|interpro:IPR018203|interpro:IPR036188|reactome:R-HSA-6803205|reactome:R-HSA-8873719|reactome:R-HSA-8876198|go:"GO:0016192"(vesicle-mediated transport)|refseq:NP_001307888.1|refseq:NP_000381.1|refseq:NP_001138886.1 ensembl:ENSG00000104067(gene)|ensembl:ENSG00000277401(gene)|ensembl:ENST00000346128(transcript)|go:"GO:0002102"(podosome)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005921"(gap junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0030054"(cell junction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034334"(adherens junction maintenance)|go:"GO:0035633"(maintenance of blood-brain barrier)|go:"GO:0042995"(cell projection)|go:"GO:0043066"(negative regulation of apoptotic process)|ensembl:ENST00000621049(transcript)|go:"GO:0043296"(apical junction complex)|go:"GO:0045177"(apical part of cell)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0045296"(cadherin binding)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0070160"(tight junction)|go:"GO:0071896"(protein localization to adherens junction)|go:"GO:0090557"(establishment of endothelial intestinal barrier)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0150105"(protein localization to cell-cell junction)|go:"GO:1901888"(regulation of cell junction assembly)|go:"GO:1902396"(protein localization to bicellular tight junction)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|go:"GO:1905605"(positive regulation of blood-brain barrier permeability)|go:"GO:2000049"(positive regulation of cell-cell adhesion mediated by cadherin)|go:"GO:2000250"(negative regulation of actin cytoskeleton reorganization)|go:"GO:2000810"(regulation of bicellular tight junction assembly)|interpro:IPR000906(ZU5)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR005417(Zona occludens protein)|interpro:IPR005418(Zona occludens protein ZO-1)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR027417|interpro:IPR036028|interpro:IPR035597|interpro:IPR036034|mint:Q07157|rcsb pdb:2H2B|rcsb pdb:2H2C|rcsb pdb:2H3M|rcsb pdb:2JWE|rcsb pdb:2KXR|rcsb pdb:2KXS|rcsb pdb:2RCZ|rcsb pdb:3CYY|rcsb pdb:3LH5|rcsb pdb:3SHU|rcsb pdb:3SHW|rcsb pdb:3TSV|rcsb pdb:3TSW|rcsb pdb:3TSZ|rcsb pdb:4OEO|rcsb pdb:4OEP|rcsb pdb:4Q2Q|rcsb pdb:4YYX|reactome:R-HSA-191650|reactome:R-HSA-2028269|reactome:R-HSA-351906|reactome:R-HSA-8935964|refseq:NP_003248.3|refseq:NP_783297.2 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/07/08 rogid:lLHJ/D4ljKMp+kSHMHu9RUTdcps9606 rogid:/Yi7U3TcH6kPu4A/bQ5Nj0QeU2w9606 intact-crc:02E62AA95A194E51|rigid:OZZTjyWFxESXZbq4Dy5CU5tDT8c false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P24386 uniprotkb:P52948 intact:EBI-2515129|ensembl:ENSP00000350386|uniprotkb:O43732|uniprotkb:A1L4D2 intact:EBI-295727|uniprotkb:Q8IUT2|uniprotkb:Q8WYB0|uniprotkb:Q96E54|uniprotkb:Q9H3Q4|uniprotkb:Q9NT02|uniprotkb:Q9UF57|uniprotkb:Q9UHX0|uniprotkb:Q9Y6J4|uniprotkb:Q9Y6J5|ensembl:ENSP00000352091 psi-mi:rae1_human(display_long)|uniprotkb:CHM(gene name)|psi-mi:CHM(display_short)|uniprotkb:REP1(gene name synonym)|uniprotkb:TCD(gene name synonym)|uniprotkb:Rab escort protein 1(gene name synonym)|uniprotkb:TCD protein(gene name synonym)|uniprotkb:Choroideremia protein(gene name synonym) psi-mi:nup98_human(display_long)|uniprotkb:NUP98(gene name)|psi-mi:NUP98(display_short)|uniprotkb:ADAR2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515120|imex:IM-12079-96 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000188419(gene)|ensembl:ENST00000357749(transcript)|go:"GO:0004663"(Rab geranylgeranyltransferase activity)|go:"GO:0005092"(GDP-dissociation inhibitor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005968"(Rab-protein geranylgeranyltransferase complex)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0007601"(visual perception)|go:"GO:0018344"(protein geranylgeranylation)|go:"GO:0031267"(small GTPase binding)|interpro:IPR001738("Rab escort (choroideraemia) protein")|interpro:IPR018203|interpro:IPR036188|reactome:R-HSA-6803205|reactome:R-HSA-8873719|reactome:R-HSA-8876198|go:"GO:0016192"(vesicle-mediated transport)|refseq:NP_001307888.1|refseq:NP_000381.1|refseq:NP_001138886.1 refseq:NP_005378.4|refseq:NP_057404.2|refseq:NP_624357.1|refseq:NP_624358.2|ensembl:ENST00000324932|ensembl:ENSP00000316032|ensembl:ENST00000355260|ensembl:ENSP00000347404|ensembl:ENSP00000352091|ensembl:ENST00000397004|ensembl:ENSP00000380199|ensembl:ENST00000397007|ensembl:ENSP00000380202|dip:DIP-32484N|ensembl:ENSG00000110713(gene)|ensembl:ENST00000359171(transcript)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003729"(mRNA binding)|go:"GO:0005215"(transporter activity)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006913"(nucleocytoplasmic transport)|go:"GO:0006999"(nuclear pore organization)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0016604"(nuclear body)|go:"GO:0017056"(structural constituent of nuclear pore)|go:"GO:0031080"(nuclear pore outer ring)|go:"GO:0031965"(nuclear membrane)|go:"GO:0034399"(nuclear periphery)|go:"GO:0042405"(nuclear inclusion body)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044615"(nuclear pore nuclear basket)|go:"GO:0048026"(positive regulation of mRNA splicing, via spliceosome)|go:"GO:0051028"(mRNA transport)|go:"GO:0051292"(nuclear pore complex assembly)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR007230(Peptidase S59, nucleoporin)|interpro:IPR021967|interpro:IPR036903|interpro:IPR037637|interpro:IPR037665|mint:P52948|rcsb pdb:1KO6|rcsb pdb:2Q5X|rcsb pdb:2Q5Y|rcsb pdb:3MMY|rcsb pdb:4OWR|rcsb pdb:5A9Q|rcsb pdb:6BZM|reactome:R-HSA-1169408|reactome:R-HSA-141444|reactome:R-HSA-159227|reactome:R-HSA-159230|reactome:R-HSA-159231|reactome:R-HSA-159236|reactome:R-HSA-165054|reactome:R-HSA-168271|reactome:R-HSA-168276|reactome:R-HSA-168325|reactome:R-HSA-168333|reactome:R-HSA-170822|reactome:R-HSA-180746|reactome:R-HSA-180910|reactome:R-HSA-191859|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-3108214|reactome:R-HSA-3232142|reactome:R-HSA-3301854|reactome:R-HSA-3371453|reactome:R-HSA-4085377|reactome:R-HSA-4551638|reactome:R-HSA-4570464|reactome:R-HSA-4615885|reactome:R-HSA-5578749|reactome:R-HSA-5619107|reactome:R-HSA-5663220|reactome:R-HSA-6784531|reactome:R-HSA-68877|reactome:R-HSA-9609690|reactome:R-HSA-9610379|reactome:R-HSA-9615933|reactome:R-HSA-9648025 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/07/08 rogid:lLHJ/D4ljKMp+kSHMHu9RUTdcps9606 rogid:aW9NaKgLZti0wLEiVQogGukcWdE9606 intact-crc:02E62AA95A194E51|rigid:OZZTjyWFxESXZbq4Dy5CU5tDT8c false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P24386 uniprotkb:Q96EE3 intact:EBI-2515129|ensembl:ENSP00000350386|uniprotkb:O43732|uniprotkb:A1L4D2 intact:EBI-922818|uniprotkb:Q8NFU6|uniprotkb:Q96MH3|uniprotkb:Q9C069|uniprotkb:A8K5B1|ensembl:ENSP00000262124 psi-mi:rae1_human(display_long)|uniprotkb:CHM(gene name)|psi-mi:CHM(display_short)|uniprotkb:REP1(gene name synonym)|uniprotkb:TCD(gene name synonym)|uniprotkb:Rab escort protein 1(gene name synonym)|uniprotkb:TCD protein(gene name synonym)|uniprotkb:Choroideremia protein(gene name synonym) psi-mi:seh1_human(display_long)|uniprotkb:Nup107-160 subcomplex subunit SEH1(gene name synonym)|uniprotkb:SEH1L(gene name)|psi-mi:SEH1L(display_short)|uniprotkb:SEC13L(gene name synonym)|uniprotkb:SEH1(gene name synonym)|uniprotkb:SEC13-like protein(gene name synonym)|uniprotkb:GATOR complex protein SEH1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515120|imex:IM-12079-96 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000188419(gene)|ensembl:ENST00000357749(transcript)|go:"GO:0004663"(Rab geranylgeranyltransferase activity)|go:"GO:0005092"(GDP-dissociation inhibitor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005968"(Rab-protein geranylgeranyltransferase complex)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0007601"(visual perception)|go:"GO:0018344"(protein geranylgeranylation)|go:"GO:0031267"(small GTPase binding)|interpro:IPR001738("Rab escort (choroideraemia) protein")|interpro:IPR018203|interpro:IPR036188|reactome:R-HSA-6803205|reactome:R-HSA-8873719|reactome:R-HSA-8876198|go:"GO:0016192"(vesicle-mediated transport)|refseq:NP_001307888.1|refseq:NP_000381.1|refseq:NP_001138886.1 refseq:NP_001013455.1|refseq:NP_112493.2|ensembl:ENSP00000262124|ensembl:ENST00000399892|ensembl:ENSP00000382779|ensembl:ENSG00000085415(gene)|ensembl:ENST00000262124(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006999"(nuclear pore organization)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0015031"(protein transport)|go:"GO:0031080"(nuclear pore outer ring)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034629"|go:"GO:0035859"(Seh1-associated complex)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051028"(mRNA transport)|go:"GO:0051301"(cell division)|go:"GO:0051315"(attachment of mitotic spindle microtubules to kinetochore)|go:"GO:0061700"(GATOR2 complex)|go:"GO:1904263"(positive regulation of TORC1 signaling)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR020472|interpro:IPR036322|interpro:IPR037363|interpro:IPR037597|mint:Q96EE3|rcsb pdb:5A9Q|reactome:R-HSA-1169408|reactome:R-HSA-141444|reactome:R-HSA-159227|reactome:R-HSA-159230|reactome:R-HSA-159231|reactome:R-HSA-159236|reactome:R-HSA-165054|reactome:R-HSA-168271|reactome:R-HSA-168276|reactome:R-HSA-168325|reactome:R-HSA-168333|reactome:R-HSA-170822|reactome:R-HSA-180746|reactome:R-HSA-180910|reactome:R-HSA-191859|reactome:R-HSA-2467813|reactome:R-HSA-2500257|reactome:R-HSA-3108214|reactome:R-HSA-3232142|reactome:R-HSA-3301854|reactome:R-HSA-3371453|reactome:R-HSA-4085377|reactome:R-HSA-4551638|reactome:R-HSA-4570464|reactome:R-HSA-4615885|reactome:R-HSA-5578749|reactome:R-HSA-5619107|reactome:R-HSA-5663220|reactome:R-HSA-6784531|reactome:R-HSA-68877|reactome:R-HSA-9609690|reactome:R-HSA-9610379|reactome:R-HSA-9615933|reactome:R-HSA-9639288|reactome:R-HSA-9648025 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/07/08 rogid:lLHJ/D4ljKMp+kSHMHu9RUTdcps9606 rogid:I/aUTa3zTawK6QwtkrUkO8B51W49606 intact-crc:02E62AA95A194E51|rigid:OZZTjyWFxESXZbq4Dy5CU5tDT8c false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P24386 uniprotkb:P09884 intact:EBI-2515129|ensembl:ENSP00000350386|uniprotkb:O43732|uniprotkb:A1L4D2 intact:EBI-850026|uniprotkb:Q86UQ7|intact:EBI-28966824|ensembl:ENSP00000368349 psi-mi:rae1_human(display_long)|uniprotkb:CHM(gene name)|psi-mi:CHM(display_short)|uniprotkb:REP1(gene name synonym)|uniprotkb:TCD(gene name synonym)|uniprotkb:Rab escort protein 1(gene name synonym)|uniprotkb:TCD protein(gene name synonym)|uniprotkb:Choroideremia protein(gene name synonym) psi-mi:dpola_human(display_long)|uniprotkb:POLA1(gene name)|psi-mi:POLA1(display_short)|uniprotkb:POLA(gene name synonym)|uniprotkb:DNA polymerase alpha catalytic subunit p180(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515120|imex:IM-12079-96 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000188419(gene)|ensembl:ENST00000357749(transcript)|go:"GO:0004663"(Rab geranylgeranyltransferase activity)|go:"GO:0005092"(GDP-dissociation inhibitor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005968"(Rab-protein geranylgeranyltransferase complex)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0007601"(visual perception)|go:"GO:0018344"(protein geranylgeranylation)|go:"GO:0031267"(small GTPase binding)|interpro:IPR001738("Rab escort (choroideraemia) protein")|interpro:IPR018203|interpro:IPR036188|reactome:R-HSA-6803205|reactome:R-HSA-8873719|reactome:R-HSA-8876198|go:"GO:0016192"(vesicle-mediated transport)|refseq:NP_001307888.1|refseq:NP_000381.1|refseq:NP_001138886.1 ensembl:ENSP00000368349|refseq:NP_058633.2|ensembl:ENSG00000101868(gene)|ensembl:ENST00000379059(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0000731"(DNA synthesis involved in DNA repair)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005658"("alpha DNA polymerase:primase complex")|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006269"(DNA replication, synthesis of RNA primer)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006271"(DNA strand elongation involved in DNA replication)|go:"GO:0006272"(leading strand elongation)|go:"GO:0006273"(lagging strand elongation)|go:"GO:0006281"(DNA repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016363"(nuclear matrix)|go:"GO:0017076"(purine nucleotide binding)|go:"GO:0019103"(pyrimidine nucleotide binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032479"(regulation of type I interferon production)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:1902975"(mitotic DNA replication initiation)|interpro:IPR006133(DNA-directed DNA polymerase, family B, exonuclease)|interpro:IPR006134(DNA-directed DNA polymerase, family B, conserved region)|interpro:IPR006172(DNA-directed DNA polymerase, family B)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR015088(Zinc finger, DNA-directed DNA polymerase, family B, alpha)|interpro:IPR017964|interpro:IPR024647|interpro:IPR036397|interpro:IPR038256|interpro:IPR042087|interpro:IPR043502|mint:P09884|rcsb pdb:1K0P|rcsb pdb:1K18|rcsb pdb:1N5G|rcsb pdb:4Q5V|rcsb pdb:4QCL|rcsb pdb:4Y97|rcsb pdb:5EXR|rcsb pdb:5IUD|rcsb pdb:6AS7|reactome:R-HSA-113501|reactome:R-HSA-174411|reactome:R-HSA-174430|reactome:R-HSA-68952|reactome:R-HSA-68962|reactome:R-HSA-69091|reactome:R-HSA-69166|reactome:R-HSA-69183|reactome:R-HSA-69205|reactome:R-HSA-9710421 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/07/08 rogid:lLHJ/D4ljKMp+kSHMHu9RUTdcps9606 rogid:X/oe9TEoaNUf5UPtWEXunsFtRZg9606 intact-crc:02E62AA95A194E51|rigid:OZZTjyWFxESXZbq4Dy5CU5tDT8c false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P24386 uniprotkb:Q7Z309 intact:EBI-2515129|ensembl:ENSP00000350386|uniprotkb:O43732|uniprotkb:A1L4D2 intact:EBI-2515087|uniprotkb:A8K902|uniprotkb:Q6ZV64|uniprotkb:Q8TB75|uniprotkb:Q6PIM2|uniprotkb:Q6ZVE4|uniprotkb:Q6ZU47|ensembl:ENSP00000359826 psi-mi:rae1_human(display_long)|uniprotkb:CHM(gene name)|psi-mi:CHM(display_short)|uniprotkb:REP1(gene name synonym)|uniprotkb:TCD(gene name synonym)|uniprotkb:Rab escort protein 1(gene name synonym)|uniprotkb:TCD protein(gene name synonym)|uniprotkb:Choroideremia protein(gene name synonym) psi-mi:pbir2_human(display_long)|uniprotkb:PABIR2(gene name)|psi-mi:PABIR2(display_short)|uniprotkb:FAM122B(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515120|imex:IM-12079-96 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000188419(gene)|ensembl:ENST00000357749(transcript)|go:"GO:0004663"(Rab geranylgeranyltransferase activity)|go:"GO:0005092"(GDP-dissociation inhibitor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005968"(Rab-protein geranylgeranyltransferase complex)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0007601"(visual perception)|go:"GO:0018344"(protein geranylgeranylation)|go:"GO:0031267"(small GTPase binding)|interpro:IPR001738("Rab escort (choroideraemia) protein")|interpro:IPR018203|interpro:IPR036188|reactome:R-HSA-6803205|reactome:R-HSA-8873719|reactome:R-HSA-8876198|go:"GO:0016192"(vesicle-mediated transport)|refseq:NP_001307888.1|refseq:NP_000381.1|refseq:NP_001138886.1 refseq:NP_001160071.1|refseq:NP_001160072.1|refseq:NP_001164227.1|refseq:NP_001164228.1|refseq:NP_660327.2|ensembl:ENSG00000156504(gene)|ensembl:ENST00000370790(transcript)|go:"GO:0004865"(protein serine/threonine phosphatase inhibitor activity)|interpro:IPR026716|refseq:XP_011529595.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/07/08 rogid:lLHJ/D4ljKMp+kSHMHu9RUTdcps9606 rogid:o/CcZrpwlteNE7GV7agrsdQRe1c9606 intact-crc:02E62AA95A194E51|rigid:OZZTjyWFxESXZbq4Dy5CU5tDT8c false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P24386 uniprotkb:Q9NXC5 intact:EBI-2515129|ensembl:ENSP00000350386|uniprotkb:O43732|uniprotkb:A1L4D2 intact:EBI-2515122|ensembl:ENSP00000339881|ensembl:ENSP00000384088|uniprotkb:Q7L551|uniprotkb:Q9H092|uniprotkb:O75216|uniprotkb:B2RTV6 psi-mi:rae1_human(display_long)|uniprotkb:CHM(gene name)|psi-mi:CHM(display_short)|uniprotkb:REP1(gene name synonym)|uniprotkb:TCD(gene name synonym)|uniprotkb:Rab escort protein 1(gene name synonym)|uniprotkb:TCD protein(gene name synonym)|uniprotkb:Choroideremia protein(gene name synonym) psi-mi:mio_human(display_long)|uniprotkb:MIOS(gene name)|psi-mi:MIOS(display_short)|uniprotkb:Missing oocyte meiosis regulator homolog(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515120|imex:IM-12079-96 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000188419(gene)|ensembl:ENST00000357749(transcript)|go:"GO:0004663"(Rab geranylgeranyltransferase activity)|go:"GO:0005092"(GDP-dissociation inhibitor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005968"(Rab-protein geranylgeranyltransferase complex)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0007601"(visual perception)|go:"GO:0018344"(protein geranylgeranylation)|go:"GO:0031267"(small GTPase binding)|interpro:IPR001738("Rab escort (choroideraemia) protein")|interpro:IPR018203|interpro:IPR036188|reactome:R-HSA-6803205|reactome:R-HSA-8873719|reactome:R-HSA-8876198|go:"GO:0016192"(vesicle-mediated transport)|refseq:NP_001307888.1|refseq:NP_000381.1|refseq:NP_001138886.1 ensembl:ENSG00000164654(gene)|ensembl:ENST00000340080(transcript)|ensembl:ENST00000405785(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0030054"(cell junction)|go:"GO:0032008"(positive regulation of TOR signaling)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034629"|go:"GO:0061700"(GATOR2 complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR031488|interpro:IPR036322|interpro:IPR037593|reactome:R-HSA-9639288|go:"GO:0005737"(cytoplasm)|refseq:NP_061878.3|refseq:XP_005249837.1|refseq:XP_005249838.1|refseq:XP_005249839.1|refseq:XP_016867850.1|dip:DIP-53801N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/07/08 rogid:lLHJ/D4ljKMp+kSHMHu9RUTdcps9606 rogid:d4qQXzBhVy/sB26TikIOei6QkwM9606 intact-crc:02E62AA95A194E51|rigid:OZZTjyWFxESXZbq4Dy5CU5tDT8c false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q15020 uniprotkb:Q9BQ75 intact:EBI-308619|uniprotkb:Q2M2H0|uniprotkb:Q58F06|uniprotkb:Q8IUS1|uniprotkb:Q96J95|uniprotkb:A8K2E4|uniprotkb:B7ZKM0|ensembl:ENSP00000449386|intact:EBI-11138149 intact:EBI-395649|uniprotkb:A8K5S7|ensembl:ENSP00000410396|uniprotkb:B4DUM1|uniprotkb:E9PHS3|intact:EBI-11119778 psi-mi:sart3_human(display_long)|uniprotkb:KIAA0156(gene name synonym)|uniprotkb:SART3(gene name)|psi-mi:SART3(display_short)|uniprotkb:TIP110(gene name synonym)|uniprotkb:Tat-interacting protein of 110 kDa(gene name synonym)|uniprotkb:p110 nuclear RNA-binding protein(gene name synonym) psi-mi:cms1_human(display_long)|uniprotkb:CMSS1(gene name)|psi-mi:CMSS1(display_short)|uniprotkb:C3orf26(gene name synonym)|uniprotkb:Cms1 ribosomal small subunit homolog(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515232|imex:IM-12079-46 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000075856(gene)|ensembl:ENST00000546815(transcript)|go:"GO:0000244"(spliceosomal tri-snRNP complex assembly)|go:"GO:0000387"(spliceosomal snRNP assembly)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0015030"(Cajal body)|go:"GO:0016607"(nuclear speck)|go:"GO:0017070"(U6 snRNA binding)|go:"GO:0030621"(U4 snRNA binding)|go:"GO:0030624"(U6atac snRNA binding)|go:"GO:0042393"(histone binding)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0061574"(ASAP complex)|go:"GO:0071425"(hematopoietic stem cell proliferation)|go:"GO:1903586"(positive regulation of histone deubiquitination)|go:"GO:1990381"(ubiquitin-specific protease binding)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR003107(RNA-processing protein, HAT helix)|interpro:IPR008669(Lsm interaction)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034217|interpro:IPR034218|interpro:IPR035979|mint:Q15020|rcsb pdb:2DO4|rcsb pdb:5CTQ|rcsb pdb:5CTR|rcsb pdb:5CTT|rcsb pdb:5JJW|rcsb pdb:5JJX|rcsb pdb:5JPZ|refseq:NP_055521.1 refseq:NP_115735.2|refseq:NP_001161396.1|ensembl:ENSG00000184220(gene)|ensembl:ENST00000421999(transcript)|go:"GO:0003723"(RNA binding)|interpro:IPR027417|interpro:IPR032704|mint:Q9BQ75 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:/71mWOMJti/LCvNo2WjCAmIYUCk9606 rogid:y335t6JRY1YTvmgzS1tQJVJGPuI9606 intact-crc:231D2FC54AEE2AF0|rigid:uJBNc5Ck55iWT9bbMHQb6vEoa4I false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q15020 uniprotkb:O43447 intact:EBI-308619|uniprotkb:Q2M2H0|uniprotkb:Q58F06|uniprotkb:Q8IUS1|uniprotkb:Q96J95|uniprotkb:A8K2E4|uniprotkb:B7ZKM0|ensembl:ENSP00000449386|intact:EBI-11138149 intact:EBI-1055615|intact:EBI-6190037|uniprotkb:A6NNE7|ensembl:ENSP00000503384|ensembl:ENSP00000503489|ensembl:ENSP00000503922|ensembl:ENSP00000504108|ensembl:ENSP00000504595|ensembl:ENSP00000361630|ensembl:ENSP00000306614 psi-mi:sart3_human(display_long)|uniprotkb:KIAA0156(gene name synonym)|uniprotkb:SART3(gene name)|psi-mi:SART3(display_short)|uniprotkb:TIP110(gene name synonym)|uniprotkb:Tat-interacting protein of 110 kDa(gene name synonym)|uniprotkb:p110 nuclear RNA-binding protein(gene name synonym) psi-mi:ppih_human(display_long)|uniprotkb:U-snRNP-associated cyclophilin SnuCyp-20(gene name synonym)|uniprotkb:Small nuclear ribonucleoprotein particle-specific cyclophilin H(gene name synonym)|uniprotkb:PPIH(gene name)|psi-mi:PPIH(display_short)|uniprotkb:CYP20(gene name synonym)|uniprotkb:CYPH(gene name synonym)|uniprotkb:Rotamase H(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515232|imex:IM-12079-46 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000075856(gene)|ensembl:ENST00000546815(transcript)|go:"GO:0000244"(spliceosomal tri-snRNP complex assembly)|go:"GO:0000387"(spliceosomal snRNP assembly)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0015030"(Cajal body)|go:"GO:0016607"(nuclear speck)|go:"GO:0017070"(U6 snRNA binding)|go:"GO:0030621"(U4 snRNA binding)|go:"GO:0030624"(U6atac snRNA binding)|go:"GO:0042393"(histone binding)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0061574"(ASAP complex)|go:"GO:0071425"(hematopoietic stem cell proliferation)|go:"GO:1903586"(positive regulation of histone deubiquitination)|go:"GO:1990381"(ubiquitin-specific protease binding)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR003107(RNA-processing protein, HAT helix)|interpro:IPR008669(Lsm interaction)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034217|interpro:IPR034218|interpro:IPR035979|mint:Q15020|rcsb pdb:2DO4|rcsb pdb:5CTQ|rcsb pdb:5CTR|rcsb pdb:5CTT|rcsb pdb:5JJW|rcsb pdb:5JJX|rcsb pdb:5JPZ|refseq:NP_055521.1 refseq:NP_006338.1|refseq:XP_005270419.1|ensembl:ENST00000304979(transcript)|ensembl:ENST00000372550(transcript)|ensembl:ENST00000676675(transcript)|ensembl:ENST00000677900(transcript)|ensembl:ENST00000678038(transcript)|ensembl:ENST00000678333(transcript)|ensembl:ENST00000678803(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006457"(protein folding)|go:"GO:0016018"(cyclosporin A binding)|go:"GO:0016607"(nuclear speck)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071001"(U4/U6 snRNP)|interpro:IPR002130(Peptidyl-prolyl cis-trans isomerase, cyclophilin-type)|interpro:IPR020892|interpro:IPR024936|interpro:IPR029000|mint:O43447|rcsb pdb:1MZW|rcsb pdb:1QOI|rcsb pdb:5O9Z|rcsb pdb:6AHD|reactome:R-HSA-72163|ensembl:ENSG00000171960(gene)|refseq:NP_001317439.1|refseq:XP_016855546.1|refseq:XP_016855547.1|refseq:XP_016855548.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:/71mWOMJti/LCvNo2WjCAmIYUCk9606 rogid:6gE98w/LLmT7FlCBnaBDk+GWvQU9606 intact-crc:231D2FC54AEE2AF0|rigid:uJBNc5Ck55iWT9bbMHQb6vEoa4I false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q15020 uniprotkb:Q6NW34 intact:EBI-308619|uniprotkb:Q2M2H0|uniprotkb:Q58F06|uniprotkb:Q8IUS1|uniprotkb:Q96J95|uniprotkb:A8K2E4|uniprotkb:B7ZKM0|ensembl:ENSP00000449386|intact:EBI-11138149 intact:EBI-2514392|ensembl:ENSP00000320251|uniprotkb:Q9H7U0|uniprotkb:Q9UFM4|uniprotkb:Q68DM6|uniprotkb:D3DN69 psi-mi:sart3_human(display_long)|uniprotkb:KIAA0156(gene name synonym)|uniprotkb:SART3(gene name)|psi-mi:SART3(display_short)|uniprotkb:TIP110(gene name synonym)|uniprotkb:Tat-interacting protein of 110 kDa(gene name synonym)|uniprotkb:p110 nuclear RNA-binding protein(gene name synonym) psi-mi:nepro_human(display_long)|uniprotkb:NEPRO(gene name)|psi-mi:NEPRO(display_short)|uniprotkb:C3orf17(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515232|imex:IM-12079-46 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000075856(gene)|ensembl:ENST00000546815(transcript)|go:"GO:0000244"(spliceosomal tri-snRNP complex assembly)|go:"GO:0000387"(spliceosomal snRNP assembly)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0015030"(Cajal body)|go:"GO:0016607"(nuclear speck)|go:"GO:0017070"(U6 snRNA binding)|go:"GO:0030621"(U4 snRNA binding)|go:"GO:0030624"(U6atac snRNA binding)|go:"GO:0042393"(histone binding)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0061574"(ASAP complex)|go:"GO:0071425"(hematopoietic stem cell proliferation)|go:"GO:1903586"(positive regulation of histone deubiquitination)|go:"GO:1990381"(ubiquitin-specific protease binding)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR003107(RNA-processing protein, HAT helix)|interpro:IPR008669(Lsm interaction)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034217|interpro:IPR034218|interpro:IPR035979|mint:Q15020|rcsb pdb:2DO4|rcsb pdb:5CTQ|rcsb pdb:5CTR|rcsb pdb:5CTT|rcsb pdb:5JJW|rcsb pdb:5JJX|rcsb pdb:5JPZ|refseq:NP_055521.1 refseq:NP_001306038.1|refseq:NP_001306039.1|refseq:NP_001306040.1|refseq:NP_001306041.1|refseq:NP_001306043.1|refseq:NP_001306044.1|ensembl:ENSG00000163608(gene)|ensembl:ENST00000314400(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|interpro:IPR027951|mint:Q6NW34|refseq:NP_056227.2 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:/71mWOMJti/LCvNo2WjCAmIYUCk9606 rogid:br4UAJBanB0yJJzizE1yXlJqtwQ9606 intact-crc:231D2FC54AEE2AF0|rigid:uJBNc5Ck55iWT9bbMHQb6vEoa4I false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q15020 uniprotkb:Q8WWY3 intact:EBI-308619|uniprotkb:Q2M2H0|uniprotkb:Q58F06|uniprotkb:Q8IUS1|uniprotkb:Q96J95|uniprotkb:A8K2E4|uniprotkb:B7ZKM0|ensembl:ENSP00000449386|intact:EBI-11138149 intact:EBI-1567797|uniprotkb:Q8N7F9|uniprotkb:Q9H271|uniprotkb:Q9Y439|uniprotkb:Q17RB4|intact:EBI-10177194|uniprotkb:F1T0A5|uniprotkb:E7ESA8|uniprotkb:F1T0A4|ensembl:ENSP00000324122|ensembl:ENSP00000483929 psi-mi:sart3_human(display_long)|uniprotkb:KIAA0156(gene name synonym)|uniprotkb:SART3(gene name)|psi-mi:SART3(display_short)|uniprotkb:TIP110(gene name synonym)|uniprotkb:Tat-interacting protein of 110 kDa(gene name synonym)|uniprotkb:p110 nuclear RNA-binding protein(gene name synonym) psi-mi:prp31_human(display_long)|uniprotkb:Pre-mRNA-processing factor 31(gene name synonym)|uniprotkb:U4/U6 snRNP 61 kDa protein(gene name synonym)|uniprotkb:Serologically defined breast cancer antigen NY-BR-99(gene name synonym)|uniprotkb:PRPF31(gene name)|psi-mi:PRPF31(display_short)|uniprotkb:PRP31(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515232|imex:IM-12079-46 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000075856(gene)|ensembl:ENST00000546815(transcript)|go:"GO:0000244"(spliceosomal tri-snRNP complex assembly)|go:"GO:0000387"(spliceosomal snRNP assembly)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0015030"(Cajal body)|go:"GO:0016607"(nuclear speck)|go:"GO:0017070"(U6 snRNA binding)|go:"GO:0030621"(U4 snRNA binding)|go:"GO:0030624"(U6atac snRNA binding)|go:"GO:0042393"(histone binding)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0061574"(ASAP complex)|go:"GO:0071425"(hematopoietic stem cell proliferation)|go:"GO:1903586"(positive regulation of histone deubiquitination)|go:"GO:1990381"(ubiquitin-specific protease binding)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR003107(RNA-processing protein, HAT helix)|interpro:IPR008669(Lsm interaction)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034217|interpro:IPR034218|interpro:IPR035979|mint:Q15020|rcsb pdb:2DO4|rcsb pdb:5CTQ|rcsb pdb:5CTR|rcsb pdb:5CTT|rcsb pdb:5JJW|rcsb pdb:5JJX|rcsb pdb:5JPZ|refseq:NP_055521.1 refseq:XP_006723200.1|refseq:NP_056444.3|ensembl:ENSG00000105618(gene)|ensembl:ENSG00000275885(gene)|ensembl:ENST00000321030(transcript)|ensembl:ENST00000613693(transcript)|go:"GO:0000244"(spliceosomal tri-snRNP complex assembly)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005684"(U2-type spliceosomal complex)|go:"GO:0071339"(MLL1 complex)|go:"GO:0097526"(spliceosomal tri-snRNP complex)|go:"GO:0005687"(U4 snRNP)|go:"GO:0005690"(U4atac snRNP)|go:"GO:0015030"(Cajal body)|go:"GO:0016607"(nuclear speck)|interpro:IPR002687(Pre-mRNA processing ribonucleoprotein, binding region)|go:"GO:0030621"(U4 snRNA binding)|go:"GO:0030622"(U4atac snRNA binding)|go:"GO:0042802"(identical protein binding)|interpro:IPR012976(NOSIC)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0070990"(snRNP binding)|interpro:IPR019175|interpro:IPR027105|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071011"(precatalytic spliceosome)|go:"GO:0071166"(ribonucleoprotein complex localization)|interpro:IPR036070|interpro:IPR042239|mint:Q8WWY3|rcsb pdb:2OZB|rcsb pdb:3JCR|rcsb pdb:3SIU|rcsb pdb:3SIV|rcsb pdb:5O9Z|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6QW6|rcsb pdb:6QX9|reactome:R-HSA-72163 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:/71mWOMJti/LCvNo2WjCAmIYUCk9606 rogid:NsXY3tY7Y2EEK8rxoisqlfpzuf89606 intact-crc:231D2FC54AEE2AF0|rigid:uJBNc5Ck55iWT9bbMHQb6vEoa4I false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q15020 uniprotkb:O95777 intact:EBI-308619|uniprotkb:Q2M2H0|uniprotkb:Q58F06|uniprotkb:Q8IUS1|uniprotkb:Q96J95|uniprotkb:A8K2E4|uniprotkb:B7ZKM0|ensembl:ENSP00000449386|intact:EBI-11138149 intact:EBI-347779|ensembl:ENSP00000249299 psi-mi:sart3_human(display_long)|uniprotkb:KIAA0156(gene name synonym)|uniprotkb:SART3(gene name)|psi-mi:SART3(display_short)|uniprotkb:TIP110(gene name synonym)|uniprotkb:Tat-interacting protein of 110 kDa(gene name synonym)|uniprotkb:p110 nuclear RNA-binding protein(gene name synonym) psi-mi:lsm8_human(display_long)|uniprotkb:LSM8(gene name)|psi-mi:LSM8(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515232|imex:IM-12079-46 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000075856(gene)|ensembl:ENST00000546815(transcript)|go:"GO:0000244"(spliceosomal tri-snRNP complex assembly)|go:"GO:0000387"(spliceosomal snRNP assembly)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0015030"(Cajal body)|go:"GO:0016607"(nuclear speck)|go:"GO:0017070"(U6 snRNA binding)|go:"GO:0030621"(U4 snRNA binding)|go:"GO:0030624"(U6atac snRNA binding)|go:"GO:0042393"(histone binding)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0061574"(ASAP complex)|go:"GO:0071425"(hematopoietic stem cell proliferation)|go:"GO:1903586"(positive regulation of histone deubiquitination)|go:"GO:1990381"(ubiquitin-specific protease binding)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR003107(RNA-processing protein, HAT helix)|interpro:IPR008669(Lsm interaction)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034217|interpro:IPR034218|interpro:IPR035979|mint:Q15020|rcsb pdb:2DO4|rcsb pdb:5CTQ|rcsb pdb:5CTR|rcsb pdb:5CTT|rcsb pdb:5JJW|rcsb pdb:5JJX|rcsb pdb:5JPZ|refseq:NP_055521.1 refseq:NP_057284.1|dip:DIP-31195N|ensembl:ENSG00000128534(gene)|ensembl:ENST00000249299(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005688"(U6 snRNP)|go:"GO:0016070"(RNA metabolic process)|go:"GO:0017070"(U6 snRNA binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071011"(precatalytic spliceosome)|go:"GO:0120115"(Lsm2-8 complex)|interpro:IPR001163(Like-Sm ribonucleoprotein, core)|interpro:IPR010920(Like-Sm ribonucleoprotein-related, core)|interpro:IPR034103|interpro:IPR044642|rcsb pdb:3JCR|rcsb pdb:5O9Z|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6QW6|rcsb pdb:6QX9|rcsb pdb:7ABG|reactome:R-HSA-72163 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:/71mWOMJti/LCvNo2WjCAmIYUCk9606 rogid:Kyf8IAEIkbe1s2NnqxqGA1o6BbU9606 intact-crc:231D2FC54AEE2AF0|rigid:uJBNc5Ck55iWT9bbMHQb6vEoa4I false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q15020 uniprotkb:P62312 intact:EBI-308619|uniprotkb:Q2M2H0|uniprotkb:Q58F06|uniprotkb:Q8IUS1|uniprotkb:Q96J95|uniprotkb:A8K2E4|uniprotkb:B7ZKM0|ensembl:ENSP00000449386|intact:EBI-11138149 intact:EBI-373310|uniprotkb:Q9Y4Y8|uniprotkb:Q4W5J5|ensembl:ENSP00000296581|ensembl:ENSP00000420929|ensembl:ENSP00000422392|ensembl:ENSP00000427036|ensembl:ENSP00000497311 psi-mi:sart3_human(display_long)|uniprotkb:KIAA0156(gene name synonym)|uniprotkb:SART3(gene name)|psi-mi:SART3(display_short)|uniprotkb:TIP110(gene name synonym)|uniprotkb:Tat-interacting protein of 110 kDa(gene name synonym)|uniprotkb:p110 nuclear RNA-binding protein(gene name synonym) psi-mi:lsm6_human(display_long)|uniprotkb:LSM6(gene name)|psi-mi:LSM6(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515232|imex:IM-12079-46 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000075856(gene)|ensembl:ENST00000546815(transcript)|go:"GO:0000244"(spliceosomal tri-snRNP complex assembly)|go:"GO:0000387"(spliceosomal snRNP assembly)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0015030"(Cajal body)|go:"GO:0016607"(nuclear speck)|go:"GO:0017070"(U6 snRNA binding)|go:"GO:0030621"(U4 snRNA binding)|go:"GO:0030624"(U6atac snRNA binding)|go:"GO:0042393"(histone binding)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0061574"(ASAP complex)|go:"GO:0071425"(hematopoietic stem cell proliferation)|go:"GO:1903586"(positive regulation of histone deubiquitination)|go:"GO:1990381"(ubiquitin-specific protease binding)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR003107(RNA-processing protein, HAT helix)|interpro:IPR008669(Lsm interaction)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034217|interpro:IPR034218|interpro:IPR035979|mint:Q15020|rcsb pdb:2DO4|rcsb pdb:5CTQ|rcsb pdb:5CTR|rcsb pdb:5CTT|rcsb pdb:5JJW|rcsb pdb:5JJX|rcsb pdb:5JPZ|refseq:NP_055521.1 refseq:NP_009011.1|ensembl:ENSG00000164167(gene)|ensembl:ENST00000296581(transcript)|ensembl:ENST00000502781(transcript)|ensembl:ENST00000504181(transcript)|ensembl:ENST00000515311(transcript)|ensembl:ENST00000649747(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000932"(P-body)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005688"(U6 snRNP)|go:"GO:0005730"(nucleolus)|go:"GO:0005732"("sno(s)RNA-containing ribonucleoprotein complex")|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006402"(mRNA catabolic process)|go:"GO:0008033"(tRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0030490"(maturation of SSU-rRNA)|go:"GO:0030532"(small nuclear ribonucleoprotein complex)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0120115"(Lsm2-8 complex)|interpro:IPR001163(Like-Sm ribonucleoprotein, core)|interpro:IPR010920(Like-Sm ribonucleoprotein-related, core)|interpro:IPR016487(Small nuclear ribonucleoprotein SmF)|mint:P62312|rcsb pdb:3JCR|rcsb pdb:5O9Z|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6QW6|rcsb pdb:6QX9|rcsb pdb:7ABG|reactome:R-HSA-430039|reactome:R-HSA-72163|refseq:XP_016863161.1|refseq:XP_016863162.1|dip:DIP-31128N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:/71mWOMJti/LCvNo2WjCAmIYUCk9606 rogid:knWeW+soIyeLSg0Xbe79er748hE9606 intact-crc:231D2FC54AEE2AF0|rigid:uJBNc5Ck55iWT9bbMHQb6vEoa4I false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q15020 uniprotkb:Q9H7B2 intact:EBI-308619|uniprotkb:Q2M2H0|uniprotkb:Q58F06|uniprotkb:Q8IUS1|uniprotkb:Q96J95|uniprotkb:A8K2E4|uniprotkb:B7ZKM0|ensembl:ENSP00000449386|intact:EBI-11138149 intact:EBI-1051960|uniprotkb:Q8N4A1|uniprotkb:Q5VXN1|ensembl:ENSP00000402338 psi-mi:sart3_human(display_long)|uniprotkb:KIAA0156(gene name synonym)|uniprotkb:SART3(gene name)|psi-mi:SART3(display_short)|uniprotkb:TIP110(gene name synonym)|uniprotkb:Tat-interacting protein of 110 kDa(gene name synonym)|uniprotkb:p110 nuclear RNA-binding protein(gene name synonym) psi-mi:rpf2_human(display_long)|uniprotkb:RPF2(gene name)|psi-mi:RPF2(display_short)|uniprotkb:BXDC1(gene name synonym)|uniprotkb:Ribosome biogenesis protein RPF2 homolog(gene name synonym)|uniprotkb:Brix domain-containing protein 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515232|imex:IM-12079-46 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000075856(gene)|ensembl:ENST00000546815(transcript)|go:"GO:0000244"(spliceosomal tri-snRNP complex assembly)|go:"GO:0000387"(spliceosomal snRNP assembly)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0015030"(Cajal body)|go:"GO:0016607"(nuclear speck)|go:"GO:0017070"(U6 snRNA binding)|go:"GO:0030621"(U4 snRNA binding)|go:"GO:0030624"(U6atac snRNA binding)|go:"GO:0042393"(histone binding)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0061574"(ASAP complex)|go:"GO:0071425"(hematopoietic stem cell proliferation)|go:"GO:1903586"(positive regulation of histone deubiquitination)|go:"GO:1990381"(ubiquitin-specific protease binding)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR003107(RNA-processing protein, HAT helix)|interpro:IPR008669(Lsm interaction)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034217|interpro:IPR034218|interpro:IPR035979|mint:Q15020|rcsb pdb:2DO4|rcsb pdb:5CTQ|rcsb pdb:5CTR|rcsb pdb:5CTT|rcsb pdb:5JJW|rcsb pdb:5JJX|rcsb pdb:5JPZ|refseq:NP_055521.1 refseq:NP_115570.1|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0008097"(5S rRNA binding)|go:"GO:0019843"(rRNA binding)|go:"GO:0042273"(ribosomal large subunit biogenesis)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1902570"(protein localization to nucleolus)|interpro:IPR007109(Brix)|interpro:IPR039770|mint:Q9H7B2|ensembl:ENSG00000197498(gene)|ensembl:ENST00000441448(transcript)|go:"GO:0000027"(ribosomal large subunit assembly)|go:"GO:0000463"("maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)") psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:/71mWOMJti/LCvNo2WjCAmIYUCk9606 rogid:CXU4CHQmcrISLS8GDIwEMGhiaQI9606 intact-crc:231D2FC54AEE2AF0|rigid:uJBNc5Ck55iWT9bbMHQb6vEoa4I false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q15020 uniprotkb:Q14331 intact:EBI-308619|uniprotkb:Q2M2H0|uniprotkb:Q58F06|uniprotkb:Q8IUS1|uniprotkb:Q96J95|uniprotkb:A8K2E4|uniprotkb:B7ZKM0|ensembl:ENSP00000449386|intact:EBI-11138149 intact:EBI-2515248|ensembl:ENSP00000226798|ensembl:ENSP00000483471|ensembl:ENSP00000489690|ensembl:ENSP00000490541|uniprotkb:A8K775 psi-mi:sart3_human(display_long)|uniprotkb:KIAA0156(gene name synonym)|uniprotkb:SART3(gene name)|psi-mi:SART3(display_short)|uniprotkb:TIP110(gene name synonym)|uniprotkb:Tat-interacting protein of 110 kDa(gene name synonym)|uniprotkb:p110 nuclear RNA-binding protein(gene name synonym) psi-mi:frg1_human(display_long)|uniprotkb:FRG1(gene name)|psi-mi:FRG1(display_short)|uniprotkb:FSHD region gene 1 protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515232|imex:IM-12079-46 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000075856(gene)|ensembl:ENST00000546815(transcript)|go:"GO:0000244"(spliceosomal tri-snRNP complex assembly)|go:"GO:0000387"(spliceosomal snRNP assembly)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0015030"(Cajal body)|go:"GO:0016607"(nuclear speck)|go:"GO:0017070"(U6 snRNA binding)|go:"GO:0030621"(U4 snRNA binding)|go:"GO:0030624"(U6atac snRNA binding)|go:"GO:0042393"(histone binding)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0061574"(ASAP complex)|go:"GO:0071425"(hematopoietic stem cell proliferation)|go:"GO:1903586"(positive regulation of histone deubiquitination)|go:"GO:1990381"(ubiquitin-specific protease binding)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR003107(RNA-processing protein, HAT helix)|interpro:IPR008669(Lsm interaction)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034217|interpro:IPR034218|interpro:IPR035979|mint:Q15020|rcsb pdb:2DO4|rcsb pdb:5CTQ|rcsb pdb:5CTR|rcsb pdb:5CTT|rcsb pdb:5JJW|rcsb pdb:5JJX|rcsb pdb:5JPZ|refseq:NP_055521.1 interpro:IPR008999(Actin_cross-linking)|interpro:IPR010414(FRG1-like)|mint:Q14331|rcsb pdb:6ZYM|rcsb pdb:7A5P|go:"GO:0071013"(catalytic step 2 spliceosome)|ensembl:ENSG00000109536(gene)|ensembl:ENSG00000275145(gene)|ensembl:ENSG00000283153(gene)|ensembl:ENSG00000283630(gene)|ensembl:ENST00000226798(transcript)|ensembl:ENST00000620886(transcript)|ensembl:ENST00000636590(transcript)|ensembl:ENST00000637998(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005730"(nucleolus)|go:"GO:0006364"(rRNA processing)|go:"GO:0007517"(muscle organ development)|go:"GO:0015030"(Cajal body)|go:"GO:0030018"(Z disc)|go:"GO:0051015"(actin filament binding)|go:"GO:0055120"(striated muscle dense body)|refseq:NP_004468.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:/71mWOMJti/LCvNo2WjCAmIYUCk9606 rogid:BRCawumXfDpZ6xqljS6j8tgxHzc9606 intact-crc:231D2FC54AEE2AF0|rigid:uJBNc5Ck55iWT9bbMHQb6vEoa4I false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q15020 uniprotkb:Q8N5C6 intact:EBI-308619|uniprotkb:Q2M2H0|uniprotkb:Q58F06|uniprotkb:Q8IUS1|uniprotkb:Q96J95|uniprotkb:A8K2E4|uniprotkb:B7ZKM0|ensembl:ENSP00000449386|intact:EBI-11138149 intact:EBI-2513767|ensembl:ENSP00000263736|uniprotkb:Q53T56|uniprotkb:Q96TA4|uniprotkb:Q9NW11 psi-mi:sart3_human(display_long)|uniprotkb:KIAA0156(gene name synonym)|uniprotkb:SART3(gene name)|psi-mi:SART3(display_short)|uniprotkb:TIP110(gene name synonym)|uniprotkb:Tat-interacting protein of 110 kDa(gene name synonym)|uniprotkb:p110 nuclear RNA-binding protein(gene name synonym) psi-mi:srbd1_human(display_long)|uniprotkb:SRBD1(gene name)|psi-mi:SRBD1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515232|imex:IM-12079-46 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000075856(gene)|ensembl:ENST00000546815(transcript)|go:"GO:0000244"(spliceosomal tri-snRNP complex assembly)|go:"GO:0000387"(spliceosomal snRNP assembly)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0015030"(Cajal body)|go:"GO:0016607"(nuclear speck)|go:"GO:0017070"(U6 snRNA binding)|go:"GO:0030621"(U4 snRNA binding)|go:"GO:0030624"(U6atac snRNA binding)|go:"GO:0042393"(histone binding)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0061574"(ASAP complex)|go:"GO:0071425"(hematopoietic stem cell proliferation)|go:"GO:1903586"(positive regulation of histone deubiquitination)|go:"GO:1990381"(ubiquitin-specific protease binding)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR003107(RNA-processing protein, HAT helix)|interpro:IPR008669(Lsm interaction)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034217|interpro:IPR034218|interpro:IPR035979|mint:Q15020|rcsb pdb:2DO4|rcsb pdb:5CTQ|rcsb pdb:5CTR|rcsb pdb:5CTT|rcsb pdb:5JJW|rcsb pdb:5JJX|rcsb pdb:5JPZ|refseq:NP_055521.1 ensembl:ENSG00000068784(gene)|ensembl:ENST00000263736(transcript)|go:"GO:0003729"(mRNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0006139"(nucleobase-containing compound metabolic process)|go:"GO:0006412"(translation)|interpro:IPR003029(S1, RNA binding)|interpro:IPR006641(Resolvase, RNase H-like fold)|interpro:IPR010994(RuvA domain 2-like)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR018974|interpro:IPR022967|interpro:IPR023319|interpro:IPR023323|interpro:IPR032639|refseq:NP_060549.4|interpro:IPR037027|interpro:IPR041692|interpro:IPR044146 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:/71mWOMJti/LCvNo2WjCAmIYUCk9606 rogid:mTBrjQa9GAzaL0m/VxFydanhbUE9606 intact-crc:231D2FC54AEE2AF0|rigid:uJBNc5Ck55iWT9bbMHQb6vEoa4I false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q15020 uniprotkb:Q9Y4Z0 intact:EBI-308619|uniprotkb:Q2M2H0|uniprotkb:Q58F06|uniprotkb:Q8IUS1|uniprotkb:Q96J95|uniprotkb:A8K2E4|uniprotkb:B7ZKM0|ensembl:ENSP00000449386|intact:EBI-11138149 intact:EBI-372521|ensembl:ENSP00000469468 psi-mi:sart3_human(display_long)|uniprotkb:KIAA0156(gene name synonym)|uniprotkb:SART3(gene name)|psi-mi:SART3(display_short)|uniprotkb:TIP110(gene name synonym)|uniprotkb:Tat-interacting protein of 110 kDa(gene name synonym)|uniprotkb:p110 nuclear RNA-binding protein(gene name synonym) psi-mi:lsm4_human(display_long)|uniprotkb:Glycine-rich protein(gene name synonym)|uniprotkb:LSM4(gene name)|psi-mi:LSM4(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515232|imex:IM-12079-46 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000075856(gene)|ensembl:ENST00000546815(transcript)|go:"GO:0000244"(spliceosomal tri-snRNP complex assembly)|go:"GO:0000387"(spliceosomal snRNP assembly)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0015030"(Cajal body)|go:"GO:0016607"(nuclear speck)|go:"GO:0017070"(U6 snRNA binding)|go:"GO:0030621"(U4 snRNA binding)|go:"GO:0030624"(U6atac snRNA binding)|go:"GO:0042393"(histone binding)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0061574"(ASAP complex)|go:"GO:0071425"(hematopoietic stem cell proliferation)|go:"GO:1903586"(positive regulation of histone deubiquitination)|go:"GO:1990381"(ubiquitin-specific protease binding)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR003107(RNA-processing protein, HAT helix)|interpro:IPR008669(Lsm interaction)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034217|interpro:IPR034218|interpro:IPR035979|mint:Q15020|rcsb pdb:2DO4|rcsb pdb:5CTQ|rcsb pdb:5CTR|rcsb pdb:5CTT|rcsb pdb:5JJW|rcsb pdb:5JJX|rcsb pdb:5JPZ|refseq:NP_055521.1 refseq:NP_036453.1|ensembl:ENSG00000130520(gene)|ensembl:ENST00000593829(transcript)|go:"GO:0000387"(spliceosomal snRNP assembly)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000932"(P-body)|go:"GO:0000956"(nuclear-transcribed mRNA catabolic process)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005688"(U6 snRNP)|go:"GO:0005829"(cytosol)|go:"GO:0008380"(RNA splicing)|go:"GO:0016020"(membrane)|go:"GO:0017070"(U6 snRNA binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033962"(P-body assembly)|go:"GO:0042731"(PH domain binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0043005"(neuron projection)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0097526"(spliceosomal tri-snRNP complex)|go:"GO:0120115"(Lsm2-8 complex)|interpro:IPR001163(Like-Sm ribonucleoprotein, core)|interpro:IPR010920(Like-Sm ribonucleoprotein-related, core)|interpro:IPR027141|interpro:IPR034101|rcsb pdb:3JCR|rcsb pdb:5O9Z|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6QW6|rcsb pdb:6QX9|rcsb pdb:7ABG|reactome:R-HSA-430039|reactome:R-HSA-72163|dip:DIP-31209N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:/71mWOMJti/LCvNo2WjCAmIYUCk9606 rogid:FlaQveuBbixGvfX47pCm26xscT09606 intact-crc:231D2FC54AEE2AF0|rigid:uJBNc5Ck55iWT9bbMHQb6vEoa4I false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q15020 uniprotkb:Q9H6E5 intact:EBI-308619|uniprotkb:Q2M2H0|uniprotkb:Q58F06|uniprotkb:Q8IUS1|uniprotkb:Q96J95|uniprotkb:A8K2E4|uniprotkb:B7ZKM0|ensembl:ENSP00000449386|intact:EBI-11138149 intact:EBI-2511680|ensembl:ENSP00000419607|uniprotkb:Q9H6H7|uniprotkb:Q7L583|uniprotkb:Q2NL65|uniprotkb:A1A527|intact:EBI-2809257|uniprotkb:A8K995 psi-mi:sart3_human(display_long)|uniprotkb:KIAA0156(gene name synonym)|uniprotkb:SART3(gene name)|psi-mi:SART3(display_short)|uniprotkb:TIP110(gene name synonym)|uniprotkb:Tat-interacting protein of 110 kDa(gene name synonym)|uniprotkb:p110 nuclear RNA-binding protein(gene name synonym) psi-mi:stpap_human(display_long)|uniprotkb:TUT1(gene name)|psi-mi:TUT1(display_short)|uniprotkb:RBM21(gene name synonym)|uniprotkb:RNA-binding motif protein 21(gene name synonym)|uniprotkb:U6 snRNA-specific terminal uridylyltransferase 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515232|imex:IM-12079-46 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000075856(gene)|ensembl:ENST00000546815(transcript)|go:"GO:0000244"(spliceosomal tri-snRNP complex assembly)|go:"GO:0000387"(spliceosomal snRNP assembly)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0015030"(Cajal body)|go:"GO:0016607"(nuclear speck)|go:"GO:0017070"(U6 snRNA binding)|go:"GO:0030621"(U4 snRNA binding)|go:"GO:0030624"(U6atac snRNA binding)|go:"GO:0042393"(histone binding)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0061574"(ASAP complex)|go:"GO:0071425"(hematopoietic stem cell proliferation)|go:"GO:1903586"(positive regulation of histone deubiquitination)|go:"GO:1990381"(ubiquitin-specific protease binding)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR003107(RNA-processing protein, HAT helix)|interpro:IPR008669(Lsm interaction)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034217|interpro:IPR034218|interpro:IPR035979|mint:Q15020|rcsb pdb:2DO4|rcsb pdb:5CTQ|rcsb pdb:5CTR|rcsb pdb:5CTT|rcsb pdb:5JJW|rcsb pdb:5JJX|rcsb pdb:5JPZ|refseq:NP_055521.1 rcsb pdb:5WU6|rcsb pdb:5WU5|ensembl:ENSG00000149016(gene)|ensembl:ENST00000476907(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0004652"(polynucleotide adenylyltransferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006378"(mRNA polyadenylation)|go:"GO:0016180"(snRNA processing)|go:"GO:0016607"(nuclear speck)|go:"GO:0016779"(nucleotidyltransferase activity)|go:"GO:0017070"(U6 snRNA binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0031123"(RNA 3'-end processing)|go:"GO:0034477"(U6 snRNA 3'-end processing)|go:"GO:0046872"(metal ion binding)|go:"GO:0050265"(RNA uridylyltransferase activity)|go:"GO:0098789"(pre-mRNA cleavage required for polyadenylation)|go:"GO:1990817"(RNA adenylyltransferase activity)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR002058(PAP/25A-associated)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034388|interpro:IPR035979|interpro:IPR036236|interpro:IPR043519|mint:Q9H6E5|rcsb pdb:2E5G|rcsb pdb:5WU1|rcsb pdb:5WU2|rcsb pdb:5WU3|rcsb pdb:5WU4|go:"GO:0005730"(nucleolus)|refseq:NP_073741.2|dip:DIP-53651N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:/71mWOMJti/LCvNo2WjCAmIYUCk9606 rogid:7Df5H4dyiKBTRo4xiRZGbzGvzbk9606 intact-crc:231D2FC54AEE2AF0|rigid:uJBNc5Ck55iWT9bbMHQb6vEoa4I false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q15020 uniprotkb:Q71F23 intact:EBI-308619|uniprotkb:Q2M2H0|uniprotkb:Q58F06|uniprotkb:Q8IUS1|uniprotkb:Q96J95|uniprotkb:A8K2E4|uniprotkb:B7ZKM0|ensembl:ENSP00000449386|intact:EBI-11138149 intact:EBI-2515234|uniprotkb:Q09GN2|ensembl:ENSP00000281453|uniprotkb:Q32Q71|uniprotkb:A2RRD9|uniprotkb:Q9H5G1 psi-mi:sart3_human(display_long)|uniprotkb:KIAA0156(gene name synonym)|uniprotkb:SART3(gene name)|psi-mi:SART3(display_short)|uniprotkb:TIP110(gene name synonym)|uniprotkb:Tat-interacting protein of 110 kDa(gene name synonym)|uniprotkb:p110 nuclear RNA-binding protein(gene name synonym) psi-mi:cenpu_human(display_long)|uniprotkb:CENPU(gene name)|psi-mi:CENPU(display_short)|uniprotkb:Centromere protein of 50 kDa(gene name synonym)|uniprotkb:ICEN24(gene name synonym)|uniprotkb:Interphase centromere complex protein 24(gene name synonym)|uniprotkb:KLIP1(gene name synonym)|uniprotkb:KSHV latent nuclear antigen-interacting protein 1(gene name synonym)|uniprotkb:MLF1-interacting protein(gene name synonym)|uniprotkb:MLF1IP(gene name synonym)|uniprotkb:PBIP1(gene name synonym)|uniprotkb:Polo-box-interacting protein 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515232|imex:IM-12079-46 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000075856(gene)|ensembl:ENST00000546815(transcript)|go:"GO:0000244"(spliceosomal tri-snRNP complex assembly)|go:"GO:0000387"(spliceosomal snRNP assembly)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0015030"(Cajal body)|go:"GO:0016607"(nuclear speck)|go:"GO:0017070"(U6 snRNA binding)|go:"GO:0030621"(U4 snRNA binding)|go:"GO:0030624"(U6atac snRNA binding)|go:"GO:0042393"(histone binding)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0061574"(ASAP complex)|go:"GO:0071425"(hematopoietic stem cell proliferation)|go:"GO:1903586"(positive regulation of histone deubiquitination)|go:"GO:1990381"(ubiquitin-specific protease binding)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR003107(RNA-processing protein, HAT helix)|interpro:IPR008669(Lsm interaction)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034217|interpro:IPR034218|interpro:IPR035979|mint:Q15020|rcsb pdb:2DO4|rcsb pdb:5CTQ|rcsb pdb:5CTR|rcsb pdb:5CTT|rcsb pdb:5JJW|rcsb pdb:5JJX|rcsb pdb:5JPZ|refseq:NP_055521.1 ensembl:ENSG00000151725(gene)|ensembl:ENST00000281453(transcript)|go:"GO:0000776"(kinetochore)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0034451"(centriolar satellite)|go:"GO:0043009"(chordate embryonic development)|interpro:IPR025214|mint:Q71F23|reactome:R-HSA-141444|reactome:R-HSA-2500257|reactome:R-HSA-5663220|reactome:R-HSA-606279|reactome:R-HSA-68877|reactome:R-HSA-9648025|reactome:R-HSA-2467813|refseq:NP_078905.2|dip:DIP-48539N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:/71mWOMJti/LCvNo2WjCAmIYUCk9606 rogid:9FtaN8LMgqRrTXtmbt5NDbKCyus9606 intact-crc:231D2FC54AEE2AF0|rigid:uJBNc5Ck55iWT9bbMHQb6vEoa4I false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q15020 uniprotkb:Q7L2J0 intact:EBI-308619|uniprotkb:Q2M2H0|uniprotkb:Q58F06|uniprotkb:Q8IUS1|uniprotkb:Q96J95|uniprotkb:A8K2E4|uniprotkb:B7ZKM0|ensembl:ENSP00000449386|intact:EBI-11138149 intact:EBI-2371983|uniprotkb:Q9NPD4|uniprotkb:B3KP86|uniprotkb:D6W5V7|ensembl:ENSP00000308546 psi-mi:sart3_human(display_long)|uniprotkb:KIAA0156(gene name synonym)|uniprotkb:SART3(gene name)|psi-mi:SART3(display_short)|uniprotkb:TIP110(gene name synonym)|uniprotkb:Tat-interacting protein of 110 kDa(gene name synonym)|uniprotkb:p110 nuclear RNA-binding protein(gene name synonym) psi-mi:mepce_human(display_long)|uniprotkb:MEPCE(gene name)|psi-mi:MEPCE(display_short)|uniprotkb:BCDIN3(gene name synonym)|uniprotkb:Bicoid-interacting protein 3 homolog(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515232|imex:IM-12079-46 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000075856(gene)|ensembl:ENST00000546815(transcript)|go:"GO:0000244"(spliceosomal tri-snRNP complex assembly)|go:"GO:0000387"(spliceosomal snRNP assembly)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0015030"(Cajal body)|go:"GO:0016607"(nuclear speck)|go:"GO:0017070"(U6 snRNA binding)|go:"GO:0030621"(U4 snRNA binding)|go:"GO:0030624"(U6atac snRNA binding)|go:"GO:0042393"(histone binding)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0061574"(ASAP complex)|go:"GO:0071425"(hematopoietic stem cell proliferation)|go:"GO:1903586"(positive regulation of histone deubiquitination)|go:"GO:1990381"(ubiquitin-specific protease binding)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR003107(RNA-processing protein, HAT helix)|interpro:IPR008669(Lsm interaction)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034217|interpro:IPR034218|interpro:IPR035979|mint:Q15020|rcsb pdb:2DO4|rcsb pdb:5CTQ|rcsb pdb:5CTR|rcsb pdb:5CTT|rcsb pdb:5JJW|rcsb pdb:5JJX|rcsb pdb:5JPZ|refseq:NP_055521.1 refseq:XP_011514712.1|refseq:NP_001181919.1|refseq:NP_001181920.1|refseq:NP_001181921.1|refseq:NP_062552.2|ensembl:ENSG00000146834(gene)|ensembl:ENST00000310512(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001510"(RNA methylation)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0008171"(O-methyltransferase activity)|go:"GO:0008173"(RNA methyltransferase activity)|go:"GO:0008757"(S-adenosylmethionine-dependent methyltransferase activity)|go:"GO:0016073"(snRNA metabolic process)|go:"GO:0017069"(snRNA binding)|go:"GO:0035562"(negative regulation of chromatin binding)|go:"GO:0040031"(snRNA modification)|go:"GO:0097322"(7SK snRNA binding)|go:"GO:0120259"(7SK snRNP)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1904871"(positive regulation of protein localization to Cajal body)|go:"GO:1905382"(positive regulation of snRNA transcription by RNA polymerase II)|go:"GO:1990276"(RNA 5'-methyltransferase activity)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR010675(Bicoid-interacting 3)|interpro:IPR024160|interpro:IPR025714|interpro:IPR029063|interpro:IPR039772|mint:Q7L2J0|rcsb pdb:5UNA|rcsb pdb:6DCB|rcsb pdb:6DCC psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:/71mWOMJti/LCvNo2WjCAmIYUCk9606 rogid:VGhJoO3FD7nsJPVSBsKuKsPJzEM9606 intact-crc:231D2FC54AEE2AF0|rigid:uJBNc5Ck55iWT9bbMHQb6vEoa4I false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q15020 uniprotkb:Q9H0S4 intact:EBI-308619|uniprotkb:Q2M2H0|uniprotkb:Q58F06|uniprotkb:Q8IUS1|uniprotkb:Q96J95|uniprotkb:A8K2E4|uniprotkb:B7ZKM0|ensembl:ENSP00000449386|intact:EBI-11138149 intact:EBI-2515241|ensembl:ENSP00000350698|uniprotkb:Q96NV8|uniprotkb:B3KXP4|uniprotkb:Q96GM0|uniprotkb:G5E955|uniprotkb:Q9UI98 psi-mi:sart3_human(display_long)|uniprotkb:KIAA0156(gene name synonym)|uniprotkb:SART3(gene name)|psi-mi:SART3(display_short)|uniprotkb:TIP110(gene name synonym)|uniprotkb:Tat-interacting protein of 110 kDa(gene name synonym)|uniprotkb:p110 nuclear RNA-binding protein(gene name synonym) psi-mi:ddx47_human(display_long)|uniprotkb:DDX47(gene name)|psi-mi:DDX47(display_short)|uniprotkb:DEAD box protein 47(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515232|imex:IM-12079-46 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000075856(gene)|ensembl:ENST00000546815(transcript)|go:"GO:0000244"(spliceosomal tri-snRNP complex assembly)|go:"GO:0000387"(spliceosomal snRNP assembly)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0015030"(Cajal body)|go:"GO:0016607"(nuclear speck)|go:"GO:0017070"(U6 snRNA binding)|go:"GO:0030621"(U4 snRNA binding)|go:"GO:0030624"(U6atac snRNA binding)|go:"GO:0042393"(histone binding)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0061574"(ASAP complex)|go:"GO:0071425"(hematopoietic stem cell proliferation)|go:"GO:1903586"(positive regulation of histone deubiquitination)|go:"GO:1990381"(ubiquitin-specific protease binding)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR003107(RNA-processing protein, HAT helix)|interpro:IPR008669(Lsm interaction)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034217|interpro:IPR034218|interpro:IPR035979|mint:Q15020|rcsb pdb:2DO4|rcsb pdb:5CTQ|rcsb pdb:5CTR|rcsb pdb:5CTT|rcsb pdb:5JJW|rcsb pdb:5JJX|rcsb pdb:5JPZ|refseq:NP_055521.1 ensembl:ENSG00000213782(gene)|ensembl:ENST00000358007(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006364"(rRNA processing)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0016020"(membrane)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR000629(RNA helicase, ATP-dependent, DEAD-box, conserved site)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|interpro:IPR044765|mint:Q9H0S4|rcsb pdb:3BER|reactome:R-HSA-6790901|reactome:R-HSA-6791226|interpro:IPR014001(DEAD-like helicase, N-terminal)|refseq:NP_057439.2|refseq:NP_957518.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:/71mWOMJti/LCvNo2WjCAmIYUCk9606 rogid:AhH5kg/8cw6L5385wUw4PR243rY9606 intact-crc:231D2FC54AEE2AF0|rigid:uJBNc5Ck55iWT9bbMHQb6vEoa4I false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q15020 uniprotkb:O43395 intact:EBI-308619|uniprotkb:Q2M2H0|uniprotkb:Q58F06|uniprotkb:Q8IUS1|uniprotkb:Q96J95|uniprotkb:A8K2E4|uniprotkb:B7ZKM0|ensembl:ENSP00000449386|intact:EBI-11138149 intact:EBI-744322|uniprotkb:O43446|uniprotkb:Q5VT54|uniprotkb:B4DSY9|intact:EBI-28983618|ensembl:ENSP00000315379 psi-mi:sart3_human(display_long)|uniprotkb:KIAA0156(gene name synonym)|uniprotkb:SART3(gene name)|psi-mi:SART3(display_short)|uniprotkb:TIP110(gene name synonym)|uniprotkb:Tat-interacting protein of 110 kDa(gene name synonym)|uniprotkb:p110 nuclear RNA-binding protein(gene name synonym) psi-mi:prpf3_human(display_long)|uniprotkb:Pre-mRNA-splicing factor 3(gene name synonym)|uniprotkb:U4/U6 snRNP 90 kDa protein(gene name synonym)|uniprotkb:PRPF3(gene name)|psi-mi:PRPF3(display_short)|uniprotkb:HPRP3(gene name synonym)|uniprotkb:PRP3(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515232|imex:IM-12079-46 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000075856(gene)|ensembl:ENST00000546815(transcript)|go:"GO:0000244"(spliceosomal tri-snRNP complex assembly)|go:"GO:0000387"(spliceosomal snRNP assembly)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0015030"(Cajal body)|go:"GO:0016607"(nuclear speck)|go:"GO:0017070"(U6 snRNA binding)|go:"GO:0030621"(U4 snRNA binding)|go:"GO:0030624"(U6atac snRNA binding)|go:"GO:0042393"(histone binding)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0061574"(ASAP complex)|go:"GO:0071425"(hematopoietic stem cell proliferation)|go:"GO:1903586"(positive regulation of histone deubiquitination)|go:"GO:1990381"(ubiquitin-specific protease binding)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR003107(RNA-processing protein, HAT helix)|interpro:IPR008669(Lsm interaction)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034217|interpro:IPR034218|interpro:IPR035979|mint:Q15020|rcsb pdb:2DO4|rcsb pdb:5CTQ|rcsb pdb:5CTR|rcsb pdb:5CTT|rcsb pdb:5JJW|rcsb pdb:5JJX|rcsb pdb:5JPZ|refseq:NP_055521.1 refseq:NP_004689.1|ensembl:ENSP00000315379|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005829"(cytosol)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0015030"(Cajal body)|go:"GO:0016607"(nuclear speck)|go:"GO:0042802"(identical protein binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0071005"(U2-type precatalytic spliceosome)|interpro:IPR002483(Splicing factor PWI)|interpro:IPR010541(Protein of unknown function DUF1115)|interpro:IPR013881(Pre-mRNA-splicing factor 3)|interpro:IPR027104|interpro:IPR036483|mint:O43395|rcsb pdb:1X4Q|rcsb pdb:3JCR|rcsb pdb:5O9Z|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6QW6|rcsb pdb:6QX9|reactome:R-HSA-72163|ensembl:ENSG00000117360(gene)|ensembl:ENST00000324862(transcript)|go:"GO:0000244"(spliceosomal tri-snRNP complex assembly)|go:"GO:0000375"(RNA splicing, via transesterification reactions)|dip:DIP-34508N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:/71mWOMJti/LCvNo2WjCAmIYUCk9606 rogid:Y2aO1gQjTU8JERVtrLpgbXq7nLU9606 intact-crc:231D2FC54AEE2AF0|rigid:uJBNc5Ck55iWT9bbMHQb6vEoa4I false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q15020 uniprotkb:O43172 intact:EBI-308619|uniprotkb:Q2M2H0|uniprotkb:Q58F06|uniprotkb:Q8IUS1|uniprotkb:Q96J95|uniprotkb:A8K2E4|uniprotkb:B7ZKM0|ensembl:ENSP00000449386|intact:EBI-11138149 intact:EBI-718395|uniprotkb:O43445|uniprotkb:O43864|uniprotkb:Q96DG2|uniprotkb:Q96IK4|uniprotkb:Q5T1M8|ensembl:ENSP00000363315 psi-mi:sart3_human(display_long)|uniprotkb:KIAA0156(gene name synonym)|uniprotkb:SART3(gene name)|psi-mi:SART3(display_short)|uniprotkb:TIP110(gene name synonym)|uniprotkb:Tat-interacting protein of 110 kDa(gene name synonym)|uniprotkb:p110 nuclear RNA-binding protein(gene name synonym) psi-mi:prp4_human(display_long)|uniprotkb:U4/U6 snRNP 60 kDa protein(gene name synonym)|uniprotkb:WD splicing factor Prp4(gene name synonym)|uniprotkb:PRP4 homolog(gene name synonym)|uniprotkb:PRPF4(gene name)|psi-mi:PRPF4(display_short)|uniprotkb:PRP4(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515232|imex:IM-12079-46 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000075856(gene)|ensembl:ENST00000546815(transcript)|go:"GO:0000244"(spliceosomal tri-snRNP complex assembly)|go:"GO:0000387"(spliceosomal snRNP assembly)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0015030"(Cajal body)|go:"GO:0016607"(nuclear speck)|go:"GO:0017070"(U6 snRNA binding)|go:"GO:0030621"(U4 snRNA binding)|go:"GO:0030624"(U6atac snRNA binding)|go:"GO:0042393"(histone binding)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0061574"(ASAP complex)|go:"GO:0071425"(hematopoietic stem cell proliferation)|go:"GO:1903586"(positive regulation of histone deubiquitination)|go:"GO:1990381"(ubiquitin-specific protease binding)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR003107(RNA-processing protein, HAT helix)|interpro:IPR008669(Lsm interaction)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034217|interpro:IPR034218|interpro:IPR035979|mint:Q15020|rcsb pdb:2DO4|rcsb pdb:5CTQ|rcsb pdb:5CTR|rcsb pdb:5CTT|rcsb pdb:5JJW|rcsb pdb:5JJX|rcsb pdb:5JPZ|refseq:NP_055521.1 refseq:NP_004688.2|refseq:NP_001231855.1|ensembl:ENSG00000136875(gene)|ensembl:ENST00000374199(transcript)|go:"GO:0000375"(RNA splicing, via transesterification reactions)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0071001"(U4/U6 snRNP)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0097525"(spliceosomal snRNP complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR014906("Pre-mRNA processing factor 4 (PRP4) like")|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|interpro:IPR015943(WD40/YVTN repeat-like)|go:"GO:0006396"(RNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0015030"(Cajal body)|go:"GO:0016607"(nuclear speck)|go:"GO:0017070"(U6 snRNA binding)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036285|interpro:IPR036322|mint:O43172|rcsb pdb:1MZW|rcsb pdb:3JCR|rcsb pdb:5O9Z|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6QW6|rcsb pdb:6QX9|reactome:R-HSA-72163|go:"GO:0030621"(U4 snRNA binding) psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:/71mWOMJti/LCvNo2WjCAmIYUCk9606 rogid:PPTNuhEFj4D+gTv/ctTTMzGmFA09606 intact-crc:231D2FC54AEE2AF0|rigid:uJBNc5Ck55iWT9bbMHQb6vEoa4I false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q15020 uniprotkb:Q9UK45 intact:EBI-308619|uniprotkb:Q2M2H0|uniprotkb:Q58F06|uniprotkb:Q8IUS1|uniprotkb:Q96J95|uniprotkb:A8K2E4|uniprotkb:B7ZKM0|ensembl:ENSP00000449386|intact:EBI-11138149 intact:EBI-348372|ensembl:ENSP00000252622 psi-mi:sart3_human(display_long)|uniprotkb:KIAA0156(gene name synonym)|uniprotkb:SART3(gene name)|psi-mi:SART3(display_short)|uniprotkb:TIP110(gene name synonym)|uniprotkb:Tat-interacting protein of 110 kDa(gene name synonym)|uniprotkb:p110 nuclear RNA-binding protein(gene name synonym) psi-mi:lsm7_human(display_long)|uniprotkb:LSM7(gene name)|psi-mi:LSM7(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515232|imex:IM-12079-46 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000075856(gene)|ensembl:ENST00000546815(transcript)|go:"GO:0000244"(spliceosomal tri-snRNP complex assembly)|go:"GO:0000387"(spliceosomal snRNP assembly)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0015030"(Cajal body)|go:"GO:0016607"(nuclear speck)|go:"GO:0017070"(U6 snRNA binding)|go:"GO:0030621"(U4 snRNA binding)|go:"GO:0030624"(U6atac snRNA binding)|go:"GO:0042393"(histone binding)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0061574"(ASAP complex)|go:"GO:0071425"(hematopoietic stem cell proliferation)|go:"GO:1903586"(positive regulation of histone deubiquitination)|go:"GO:1990381"(ubiquitin-specific protease binding)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR003107(RNA-processing protein, HAT helix)|interpro:IPR008669(Lsm interaction)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034217|interpro:IPR034218|interpro:IPR035979|mint:Q15020|rcsb pdb:2DO4|rcsb pdb:5CTQ|rcsb pdb:5CTR|rcsb pdb:5CTT|rcsb pdb:5JJW|rcsb pdb:5JJX|rcsb pdb:5JPZ|refseq:NP_055521.1 refseq:NP_057283.1|interpro:IPR017132(U6 snRNA-associated Sm-like protein LSm7)|interpro:IPR044641|rcsb pdb:3JCR|rcsb pdb:5O9Z|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6QW6|rcsb pdb:6QX9|rcsb pdb:7ABG|reactome:R-HSA-430039|reactome:R-HSA-72163|go:"GO:0005689"(U12-type spliceosomal complex)|go:"GO:0005829"(cytosol)|go:"GO:0017070"(U6 snRNA binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0071004"(U2-type prespliceosome)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0097526"(spliceosomal tri-snRNP complex)|go:"GO:0120115"(Lsm2-8 complex)|go:"GO:1990726"(Lsm1-7-Pat1 complex)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR001163(Like-Sm ribonucleoprotein, core)|interpro:IPR010920(Like-Sm ribonucleoprotein-related, core)|ensembl:ENSG00000130332(gene)|ensembl:ENST00000252622(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000956"(nuclear-transcribed mRNA catabolic process)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005688"(U6 snRNP)|dip:DIP-31129N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:/71mWOMJti/LCvNo2WjCAmIYUCk9606 rogid:vT1gI3yzYl37cX++CUGdJowAL909606 intact-crc:231D2FC54AEE2AF0|rigid:uJBNc5Ck55iWT9bbMHQb6vEoa4I false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q15020 uniprotkb:Q9Y333 intact:EBI-308619|uniprotkb:Q2M2H0|uniprotkb:Q58F06|uniprotkb:Q8IUS1|uniprotkb:Q96J95|uniprotkb:A8K2E4|uniprotkb:B7ZKM0|ensembl:ENSP00000449386|intact:EBI-11138149 intact:EBI-347416|uniprotkb:Q6FGG1|ensembl:ENSP00000414006|ensembl:ENSP00000414634|ensembl:ENSP00000406280|ensembl:ENSP00000364813|ensembl:ENSP00000372883|ensembl:ENSP00000403345 psi-mi:sart3_human(display_long)|uniprotkb:KIAA0156(gene name synonym)|uniprotkb:SART3(gene name)|psi-mi:SART3(display_short)|uniprotkb:TIP110(gene name synonym)|uniprotkb:Tat-interacting protein of 110 kDa(gene name synonym)|uniprotkb:p110 nuclear RNA-binding protein(gene name synonym) psi-mi:lsm2_human(display_long)|uniprotkb:LSM2(gene name)|psi-mi:LSM2(display_short)|uniprotkb:C6orf28(gene name synonym)|uniprotkb:G7B(gene name synonym)|uniprotkb:snRNP core Sm-like protein Sm-x5(gene name synonym)|uniprotkb:Small nuclear ribonuclear protein D homolog(gene name synonym)|uniprotkb:Protein G7b(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515232|imex:IM-12079-46 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000075856(gene)|ensembl:ENST00000546815(transcript)|go:"GO:0000244"(spliceosomal tri-snRNP complex assembly)|go:"GO:0000387"(spliceosomal snRNP assembly)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0015030"(Cajal body)|go:"GO:0016607"(nuclear speck)|go:"GO:0017070"(U6 snRNA binding)|go:"GO:0030621"(U4 snRNA binding)|go:"GO:0030624"(U6atac snRNA binding)|go:"GO:0042393"(histone binding)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0061574"(ASAP complex)|go:"GO:0071425"(hematopoietic stem cell proliferation)|go:"GO:1903586"(positive regulation of histone deubiquitination)|go:"GO:1990381"(ubiquitin-specific protease binding)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR003107(RNA-processing protein, HAT helix)|interpro:IPR008669(Lsm interaction)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034217|interpro:IPR034218|interpro:IPR035979|mint:Q15020|rcsb pdb:2DO4|rcsb pdb:5CTQ|rcsb pdb:5CTR|rcsb pdb:5CTT|rcsb pdb:5JJW|rcsb pdb:5JJX|rcsb pdb:5JPZ|refseq:NP_055521.1 refseq:NP_067000.1|ensembl:ENST00000375661(transcript)|ensembl:ENST00000383391(transcript)|ensembl:ENST00000424975(transcript)|ensembl:ENST00000432122(transcript)|ensembl:ENST00000434125(transcript)|ensembl:ENST00000455705(transcript)|go:"GO:0000244"(spliceosomal tri-snRNP complex assembly)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000932"(P-body)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005688"(U6 snRNP)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006402"(mRNA catabolic process)|go:"GO:0017070"(U6 snRNA binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0046540"(U4/U6 x U5 tri-snRNP complex)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071011"(precatalytic spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0120115"(Lsm2-8 complex)|go:"GO:1990726"(Lsm1-7-Pat1 complex)|interpro:IPR001163(Like-Sm ribonucleoprotein, core)|interpro:IPR010920(Like-Sm ribonucleoprotein-related, core)|interpro:IPR016654(U6 snRNA-associated Sm-like protein LSm2)|mint:Q9Y333|rcsb pdb:3JCR|rcsb pdb:5O9Z|rcsb pdb:6AH0|rcsb pdb:6AHD|rcsb pdb:6QW6|rcsb pdb:6QX9|rcsb pdb:7ABG|reactome:R-HSA-430039|reactome:R-HSA-72163|reactome:R-HSA-72165|ensembl:ENSG00000172850(gene)|ensembl:ENSG00000204392(gene)|ensembl:ENSG00000224979(gene)|ensembl:ENSG00000225998(gene)|ensembl:ENSG00000231502(gene)|ensembl:ENSG00000236826(gene)|dip:DIP-31139N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:/71mWOMJti/LCvNo2WjCAmIYUCk9606 rogid:lReyYTJxC/WlYg/ekKaqZiNNdVM9606 intact-crc:231D2FC54AEE2AF0|rigid:uJBNc5Ck55iWT9bbMHQb6vEoa4I false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q15020 uniprotkb:Q9Y3B9 intact:EBI-308619|uniprotkb:Q2M2H0|uniprotkb:Q58F06|uniprotkb:Q8IUS1|uniprotkb:Q96J95|uniprotkb:A8K2E4|uniprotkb:B7ZKM0|ensembl:ENSP00000449386|intact:EBI-11138149 intact:EBI-1055610|intact:EBI-28979625|ensembl:ENSP00000355899 psi-mi:sart3_human(display_long)|uniprotkb:KIAA0156(gene name synonym)|uniprotkb:SART3(gene name)|psi-mi:SART3(display_short)|uniprotkb:TIP110(gene name synonym)|uniprotkb:Tat-interacting protein of 110 kDa(gene name synonym)|uniprotkb:p110 nuclear RNA-binding protein(gene name synonym) psi-mi:rrp15_human(display_long)|uniprotkb:Ribosomal RNA-processing protein 15(gene name synonym)|uniprotkb:RRP15(gene name)|psi-mi:RRP15(display_short)|uniprotkb:KIAA0507(gene name synonym)|uniprotkb:CGI-115(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515232|imex:IM-12079-46 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000075856(gene)|ensembl:ENST00000546815(transcript)|go:"GO:0000244"(spliceosomal tri-snRNP complex assembly)|go:"GO:0000387"(spliceosomal snRNP assembly)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0015030"(Cajal body)|go:"GO:0016607"(nuclear speck)|go:"GO:0017070"(U6 snRNA binding)|go:"GO:0030621"(U4 snRNA binding)|go:"GO:0030624"(U6atac snRNA binding)|go:"GO:0042393"(histone binding)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0061574"(ASAP complex)|go:"GO:0071425"(hematopoietic stem cell proliferation)|go:"GO:1903586"(positive regulation of histone deubiquitination)|go:"GO:1990381"(ubiquitin-specific protease binding)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR003107(RNA-processing protein, HAT helix)|interpro:IPR008669(Lsm interaction)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034217|interpro:IPR034218|interpro:IPR035979|mint:Q15020|rcsb pdb:2DO4|rcsb pdb:5CTQ|rcsb pdb:5CTR|rcsb pdb:5CTT|rcsb pdb:5JJW|rcsb pdb:5JJX|rcsb pdb:5JPZ|refseq:NP_055521.1 ensembl:ENSP00000355899|refseq:NP_057136.2|ensembl:ENSG00000067533(gene)|ensembl:ENST00000366932(transcript)|go:"GO:0000460"(maturation of 5.8S rRNA)|go:"GO:0000470"(maturation of LSU-rRNA)|go:"GO:0030687"(preribosome, large subunit precursor)|interpro:IPR012459(Protein of unknown function DUF1665) psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:/71mWOMJti/LCvNo2WjCAmIYUCk9606 rogid:EJQFG76HKEYeJ6LwFd5zaUmoScw9606 intact-crc:231D2FC54AEE2AF0|rigid:uJBNc5Ck55iWT9bbMHQb6vEoa4I false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UM82 uniprotkb:O14936 intact:EBI-744066|uniprotkb:O94857|uniprotkb:E1P626|ensembl:ENSP00000289431|ensembl:ENSP00000416799 intact:EBI-1215506|uniprotkb:Q5VT18|uniprotkb:Q5VT19|uniprotkb:Q66T42|uniprotkb:A6NES1|uniprotkb:O43215|uniprotkb:Q17RI4|uniprotkb:Q59HA0|uniprotkb:Q5VT16|uniprotkb:Q5VT17|uniprotkb:Q9BYH6|uniprotkb:Q9NYB2|uniprotkb:Q9NYB3|uniprotkb:B7ZKY0|ensembl:ENSP00000367405 psi-mi:spat2_human(display_long)|uniprotkb:SPATA2(gene name)|psi-mi:SPATA2(display_short)|uniprotkb:KIAA0757(gene name synonym)|uniprotkb:PD1(gene name synonym) psi-mi:cskp_human(display_long)|uniprotkb:CASK(gene name)|psi-mi:CASK(display_short)|uniprotkb:LIN2(gene name synonym)|uniprotkb:Calcium/calmodulin-dependent serine protein kinase(gene name synonym)|uniprotkb:Protein lin-2 homolog(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515297|imex:IM-12079-97 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001129245.1|refseq:NP_006029.1|refseq:XP_011527418.1|ensembl:ENSG00000158480(gene)|ensembl:ENST00000289431(transcript)|ensembl:ENST00000422556(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0007283"(spermatogenesis)|go:"GO:0010803"(regulation of tumor necrosis factor-mediated signaling pathway)|refseq:XP_006723957.1|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0060544"(regulation of necroptotic process)|go:"GO:0070266"(necroptotic process)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0072520"(seminiferous tubule development)|go:"GO:1990108"(protein linear deubiquitination)|go:"GO:1990381"(ubiquitin-specific protease binding)|interpro:IPR029744|mint:Q9UM82|rcsb pdb:5LJM|rcsb pdb:5LJN refseq:NP_001119526.1|refseq:NP_001119527.1|refseq:NP_003679.2|dip:DIP-38727N|ensembl:ENSG00000147044(gene)|ensembl:ENST00000378163(transcript)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0004385"(guanylate kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005604"(basement membrane)|go:"GO:0005652"(nuclear lamina)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007155"(cell adhesion)|go:"GO:0010839"(negative regulation of keratinocyte proliferation)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016363"(nuclear matrix)|go:"GO:0031982"(vesicle)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0060170"(ciliary membrane)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0070509"(calcium ion import)|go:"GO:0090280"(positive regulation of calcium ion import)|go:"GO:0090288"(negative regulation of cellular response to growth factor stimulus)|rcsb pdb:3MFT|rcsb pdb:3MFU|rcsb pdb:3TAC|rcsb pdb:6KMH|rcsb pdb:7OAI|rcsb pdb:7OAJ|rcsb pdb:7OAK|rcsb pdb:7OAL|reactome:R-HSA-212676|reactome:R-HSA-3000170|reactome:R-HSA-373753|reactome:R-HSA-6794361|reactome:R-HSA-9609736|reactome:R-HSA-9662360|reactome:R-HSA-9662361|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR004172(L27)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR011009(Protein kinase-like)|interpro:IPR014775(L27, C-terminal)|interpro:IPR020590|interpro:IPR027417|interpro:IPR035473|interpro:IPR036028|interpro:IPR036034|interpro:IPR036892|mint:O14936|rcsb pdb:1KGD|rcsb pdb:1KWA|rcsb pdb:1ZL8|rcsb pdb:3C0G|rcsb pdb:3C0H|rcsb pdb:3C0I|rcsb pdb:3MFR|rcsb pdb:3MFS psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:VwbVhr/GuqylbroxXXcpBpWAXvM9606 rogid:zTaBgQexJON3EVgJq9FHjf+aSCY9606 intact-crc:4005DFB74B0B6633|rigid:Fgovrv4jWmoNOfiu56hccfzhp2Y false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UM82 uniprotkb:Q9NQP4 intact:EBI-744066|uniprotkb:O94857|uniprotkb:E1P626|ensembl:ENSP00000289431|ensembl:ENSP00000416799 intact:EBI-357021|uniprotkb:Q5TD11|uniprotkb:Q92779|ensembl:ENSP00000360473 psi-mi:spat2_human(display_long)|uniprotkb:SPATA2(gene name)|psi-mi:SPATA2(display_short)|uniprotkb:KIAA0757(gene name synonym)|uniprotkb:PD1(gene name synonym) psi-mi:pfd4_human(display_long)|uniprotkb:PFDN4(gene name)|psi-mi:PFDN4(display_short)|uniprotkb:PFD4(gene name synonym)|uniprotkb:Protein C-1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515297|imex:IM-12079-97 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001129245.1|refseq:NP_006029.1|refseq:XP_011527418.1|ensembl:ENSG00000158480(gene)|ensembl:ENST00000289431(transcript)|ensembl:ENST00000422556(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0007283"(spermatogenesis)|go:"GO:0010803"(regulation of tumor necrosis factor-mediated signaling pathway)|refseq:XP_006723957.1|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0060544"(regulation of necroptotic process)|go:"GO:0070266"(necroptotic process)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0072520"(seminiferous tubule development)|go:"GO:1990108"(protein linear deubiquitination)|go:"GO:1990381"(ubiquitin-specific protease binding)|interpro:IPR029744|mint:Q9UM82|rcsb pdb:5LJM|rcsb pdb:5LJN refseq:NP_002614.2|ensembl:ENSG00000101132(gene)|ensembl:ENST00000371419(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0016272"(prefoldin complex)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:1905907"(negative regulation of amyloid fibril formation)|interpro:IPR002777(Prefoldin beta-like)|interpro:IPR009053(Prefoldin)|interpro:IPR016661(Prefoldin, subunit 4)|mint:Q9NQP4|rcsb pdb:6NR8|rcsb pdb:6NR9|rcsb pdb:6NRB|rcsb pdb:6NRC|rcsb pdb:6NRD|reactome:R-HSA-389957 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:VwbVhr/GuqylbroxXXcpBpWAXvM9606 rogid:oXbJiHxqcYHrAWGGgzV81ocGt889606 intact-crc:4005DFB74B0B6633|rigid:Fgovrv4jWmoNOfiu56hccfzhp2Y false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UM82 uniprotkb:P38405 intact:EBI-744066|uniprotkb:O94857|uniprotkb:E1P626|ensembl:ENSP00000289431|ensembl:ENSP00000416799 intact:EBI-2512639|ensembl:ENSP00000269162|ensembl:ENSP00000408489|ensembl:ENSP00000439023|uniprotkb:Q86XU3|uniprotkb:B7ZA26 psi-mi:spat2_human(display_long)|uniprotkb:SPATA2(gene name)|psi-mi:SPATA2(display_short)|uniprotkb:KIAA0757(gene name synonym)|uniprotkb:PD1(gene name synonym) psi-mi:gnal_human(display_long)|uniprotkb:GNAL(gene name)|psi-mi:GNAL(display_short)|uniprotkb:Adenylate cyclase-stimulating G alpha protein, olfactory type(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515297|imex:IM-12079-97 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001129245.1|refseq:NP_006029.1|refseq:XP_011527418.1|ensembl:ENSG00000158480(gene)|ensembl:ENST00000289431(transcript)|ensembl:ENST00000422556(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0007283"(spermatogenesis)|go:"GO:0010803"(regulation of tumor necrosis factor-mediated signaling pathway)|refseq:XP_006723957.1|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0060544"(regulation of necroptotic process)|go:"GO:0070266"(necroptotic process)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0072520"(seminiferous tubule development)|go:"GO:1990108"(protein linear deubiquitination)|go:"GO:1990381"(ubiquitin-specific protease binding)|interpro:IPR029744|mint:Q9UM82|rcsb pdb:5LJM|rcsb pdb:5LJN ensembl:ENSG00000141404(gene)|ensembl:ENST00000269162(transcript)|ensembl:ENST00000423027(transcript)|ensembl:ENST00000535121(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007191"(adenylate cyclase-activating dopamine receptor signaling pathway)|go:"GO:0007606"(sensory perception of chemical stimulus)|go:"GO:0031683"(G-protein beta/gamma-subunit complex binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000367(G-protein alpha subunit, group S)|interpro:IPR001019("Guanine nucleotide binding protein (G-protein), alpha subunit")|interpro:IPR011025(G protein alpha subunit, helical insertion)|interpro:IPR027417|reactome:R-HSA-170660|reactome:R-HSA-170670|reactome:R-HSA-381753|refseq:NP_001135811.1|refseq:NP_892023.1|refseq:NP_001248372.1|refseq:NP_001248373.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:VwbVhr/GuqylbroxXXcpBpWAXvM9606 rogid:IC+CI3TYQdbioxaPBNu/cSGn7TQ9606 intact-crc:4005DFB74B0B6633|rigid:Fgovrv4jWmoNOfiu56hccfzhp2Y false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UM82 uniprotkb:Q9NWV8 intact:EBI-744066|uniprotkb:O94857|uniprotkb:E1P626|ensembl:ENSP00000289431|ensembl:ENSP00000416799 intact:EBI-745725|uniprotkb:Q6FIA0|uniprotkb:Q9P018|uniprotkb:A8MQT0|uniprotkb:B4DRY9|uniprotkb:B4DVR1|ensembl:ENSP00000352408|ensembl:ENSP00000470920|ensembl:ENSP00000471605 psi-mi:spat2_human(display_long)|uniprotkb:SPATA2(gene name)|psi-mi:SPATA2(display_short)|uniprotkb:KIAA0757(gene name synonym)|uniprotkb:PD1(gene name synonym) psi-mi:baba1_human(display_long)|uniprotkb:BABAM1(gene name)|psi-mi:BABAM1(display_short)|uniprotkb:HSPC142(orf name)|uniprotkb:C19orf62(gene name synonym)|uniprotkb:NBA1(gene name synonym)|uniprotkb:Mediator of RAP80 interactions and targeting subunit of 40 kDa(gene name synonym)|uniprotkb:New component of the BRCA1-A complex(gene name synonym)|uniprotkb:MERIT40(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515297|imex:IM-12079-97 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001129245.1|refseq:NP_006029.1|refseq:XP_011527418.1|ensembl:ENSG00000158480(gene)|ensembl:ENST00000289431(transcript)|ensembl:ENST00000422556(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0007283"(spermatogenesis)|go:"GO:0010803"(regulation of tumor necrosis factor-mediated signaling pathway)|refseq:XP_006723957.1|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0060544"(regulation of necroptotic process)|go:"GO:0070266"(necroptotic process)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0072520"(seminiferous tubule development)|go:"GO:1990108"(protein linear deubiquitination)|go:"GO:1990381"(ubiquitin-specific protease binding)|interpro:IPR029744|mint:Q9UM82|rcsb pdb:5LJM|rcsb pdb:5LJN refseq:NP_001028721.1|refseq:NP_054892.2|ensembl:ENSG00000105393(gene)|ensembl:ENST00000359435(transcript)|ensembl:ENST00000598188(transcript)|ensembl:ENST00000601043(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006325"(chromatin organization)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016604"(nuclear body)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0051301"(cell division)|go:"GO:0070531"(BRCA1-A complex)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0070552"(BRISC complex)|interpro:IPR026126|interpro:IPR036465|mint:Q9NWV8|rcsb pdb:6H3C|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473|refseq:NP_001275685.1|refseq:NP_001275686.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:VwbVhr/GuqylbroxXXcpBpWAXvM9606 rogid:o71OvjzuL/7w4247ap7fm6i3pXU9606 intact-crc:4005DFB74B0B6633|rigid:Fgovrv4jWmoNOfiu56hccfzhp2Y false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UM82 uniprotkb:Q9NQC7 intact:EBI-744066|uniprotkb:O94857|uniprotkb:E1P626|ensembl:ENSP00000289431|ensembl:ENSP00000416799 intact:EBI-2117940|uniprotkb:O94934|uniprotkb:Q7L3N6|uniprotkb:Q96EH0|uniprotkb:Q9NZX9|ensembl:ENSP00000308928|ensembl:ENSP00000392025 psi-mi:spat2_human(display_long)|uniprotkb:SPATA2(gene name)|psi-mi:SPATA2(display_short)|uniprotkb:KIAA0757(gene name synonym)|uniprotkb:PD1(gene name synonym) psi-mi:cyld_human(display_long)|uniprotkb:Ubiquitin thioesterase CYLD(gene name synonym)|uniprotkb:CYLD(gene name)|psi-mi:CYLD(display_short)|uniprotkb:CYLD1(gene name synonym)|uniprotkb:KIAA0849(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease CYLD(gene name synonym)|uniprotkb:Deubiquitinating enzyme CYLD(gene name synonym)|uniprotkb:HSPC057(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515297|imex:IM-12079-97 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001129245.1|refseq:NP_006029.1|refseq:XP_011527418.1|ensembl:ENSG00000158480(gene)|ensembl:ENST00000289431(transcript)|ensembl:ENST00000422556(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0007283"(spermatogenesis)|go:"GO:0010803"(regulation of tumor necrosis factor-mediated signaling pathway)|refseq:XP_006723957.1|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0060544"(regulation of necroptotic process)|go:"GO:0070266"(necroptotic process)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0072520"(seminiferous tubule development)|go:"GO:1990108"(protein linear deubiquitination)|go:"GO:1990381"(ubiquitin-specific protease binding)|interpro:IPR029744|mint:Q9UM82|rcsb pdb:5LJM|rcsb pdb:5LJN refseq:NP_001035814.1|refseq:NP_001035877.1|refseq:NP_056062.1|refseq:XP_016878467.1|refseq:XP_016878469.1|go:"GO:0007049"(cell cycle)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010803"(regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0005874"(microtubule)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032480"(negative regulation of type I interferon production)|go:"GO:0036064"(ciliary basal body)|go:"GO:0045087"(innate immune response)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0060544"(regulation of necroptotic process)|go:"GO:0061578"(Lys63-specific deubiquitinase activity)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0070266"(necroptotic process)|go:"GO:0070423"(nucleotide-binding oligomerization domain containing signaling pathway)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097542"(ciliary tip)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1902017"(regulation of cilium assembly)|go:"GO:1903753"(negative regulation of p38MAPK cascade)|go:"GO:1990108"(protein linear deubiquitination)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|go:"GO:2001242"(regulation of intrinsic apoptotic signaling pathway)|interpro:IPR000938(Cytoskeleton-associated protein, CAP-Gly)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR036859|interpro:IPR038765|mint:Q9NQC7|rcsb pdb:1IXD|rcsb pdb:1WHL|rcsb pdb:1WHM|rcsb pdb:2VHF|reactome:R-HSA-168638|reactome:R-HSA-5357786|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5689880|reactome:R-HSA-936440|ensembl:ENSG00000083799(gene)|ensembl:ENST00000311559(transcript)|ensembl:ENST00000427738(transcript)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|refseq:XP_005255869.1|refseq:XP_006721212.1|refseq:XP_011521209.1|refseq:XP_016878466.1|refseq:XP_016878468.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:VwbVhr/GuqylbroxXXcpBpWAXvM9606 rogid:Z01woAwtDVaoNnAthw9tTrBqRao9606 intact-crc:4005DFB74B0B6633|rigid:Fgovrv4jWmoNOfiu56hccfzhp2Y false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UM82 uniprotkb:Q9NUP9 intact:EBI-744066|uniprotkb:O94857|uniprotkb:E1P626|ensembl:ENSP00000289431|ensembl:ENSP00000416799 intact:EBI-1171517|ensembl:ENSP00000278193 psi-mi:spat2_human(display_long)|uniprotkb:SPATA2(gene name)|psi-mi:SPATA2(display_short)|uniprotkb:KIAA0757(gene name synonym)|uniprotkb:PD1(gene name synonym) psi-mi:lin7c_human(display_long)|uniprotkb:Mammalian lin-seven protein 3(gene name synonym)|uniprotkb:Vertebrate lin-7 homolog 3(gene name synonym)|uniprotkb:LIN7C(gene name)|psi-mi:LIN7C(display_short)|uniprotkb:MALS3(gene name synonym)|uniprotkb:VELI3(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515297|imex:IM-12079-97 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001129245.1|refseq:NP_006029.1|refseq:XP_011527418.1|ensembl:ENSG00000158480(gene)|ensembl:ENST00000289431(transcript)|ensembl:ENST00000422556(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0007283"(spermatogenesis)|go:"GO:0010803"(regulation of tumor necrosis factor-mediated signaling pathway)|refseq:XP_006723957.1|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0060544"(regulation of necroptotic process)|go:"GO:0070266"(necroptotic process)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0072520"(seminiferous tubule development)|go:"GO:1990108"(protein linear deubiquitination)|go:"GO:1990381"(ubiquitin-specific protease binding)|interpro:IPR029744|mint:Q9UM82|rcsb pdb:5LJM|rcsb pdb:5LJN refseq:NP_060832.1|ensembl:ENSG00000148943(gene)|ensembl:ENST00000278193(transcript)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006887"(exocytosis)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0015031"(protein transport)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0045199"(maintenance of epithelial cell apical/basal polarity)|go:"GO:0045202"(synapse)|go:"GO:0097016"(L27 domain binding)|go:"GO:0097025"(MPP7-DLG1-LIN7 complex)|go:"GO:0098793"(presynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1903361"(protein localization to basolateral plasma membrane)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR004172(L27)|interpro:IPR014775(L27, C-terminal)|interpro:IPR017365(Lin-7 homologue)|interpro:IPR036034|interpro:IPR036892|mint:Q9NUP9|rcsb pdb:3LRA|reactome:R-HSA-212676|reactome:R-HSA-6794361|reactome:R-HSA-9609736 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:VwbVhr/GuqylbroxXXcpBpWAXvM9606 rogid:F2rasaJ64Olc9qScN79LJRqsUEE9606 intact-crc:4005DFB74B0B6633|rigid:Fgovrv4jWmoNOfiu56hccfzhp2Y false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UM82 uniprotkb:O15212 intact:EBI-744066|uniprotkb:O94857|uniprotkb:E1P626|ensembl:ENSP00000289431|ensembl:ENSP00000416799 intact:EBI-356973|ensembl:ENSP00000363734|ensembl:ENSP00000363735|ensembl:ENSP00000363738|ensembl:ENSP00000372694|ensembl:ENSP00000378563|ensembl:ENSP00000382314|ensembl:ENSP00000382316|ensembl:ENSP00000395462|ensembl:ENSP00000398171|ensembl:ENSP00000400152|ensembl:ENSP00000402212|ensembl:ENSP00000402553|ensembl:ENSP00000403771|ensembl:ENSP00000404773|ensembl:ENSP00000412319|ensembl:ENSP00000415678|ensembl:ENSP00000447540|ensembl:ENSP00000448607|ensembl:ENSP00000448784|ensembl:ENSP00000449925 psi-mi:spat2_human(display_long)|uniprotkb:SPATA2(gene name)|psi-mi:SPATA2(display_short)|uniprotkb:KIAA0757(gene name synonym)|uniprotkb:PD1(gene name synonym) psi-mi:pfd6_human(display_long)|uniprotkb:PFDN6(gene name)|psi-mi:PFDN6(display_short)|uniprotkb:HKE2(gene name synonym)|uniprotkb:PFD6(gene name synonym)|uniprotkb:Protein Ke2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515297|imex:IM-12079-97 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001129245.1|refseq:NP_006029.1|refseq:XP_011527418.1|ensembl:ENSG00000158480(gene)|ensembl:ENST00000289431(transcript)|ensembl:ENST00000422556(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0007283"(spermatogenesis)|go:"GO:0010803"(regulation of tumor necrosis factor-mediated signaling pathway)|refseq:XP_006723957.1|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0060544"(regulation of necroptotic process)|go:"GO:0070266"(necroptotic process)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0072520"(seminiferous tubule development)|go:"GO:1990108"(protein linear deubiquitination)|go:"GO:1990381"(ubiquitin-specific protease binding)|interpro:IPR029744|mint:Q9UM82|rcsb pdb:5LJM|rcsb pdb:5LJN refseq:NP_001172110.1|refseq:NP_055075.1|refseq:NP_001252524.1|refseq:NP_001252525.1|dip:DIP-50304N|ensembl:ENSG00000204220(gene)|ensembl:ENSG00000206283(gene)|ensembl:ENSG00000224782(gene)|ensembl:ENSG00000235692(gene)|ensembl:ENSG00000237335(gene)|ensembl:ENST00000374606(transcript)|ensembl:ENST00000374607(transcript)|ensembl:ENST00000374610(transcript)|ensembl:ENST00000383207(transcript)|ensembl:ENST00000395131(transcript)|ensembl:ENST00000399383(transcript)|ensembl:ENST00000399385(transcript)|ensembl:ENST00000412289(transcript)|ensembl:ENST00000425878(transcript)|ensembl:ENST00000431830(transcript)|ensembl:ENST00000432391(transcript)|ensembl:ENST00000442285(transcript)|ensembl:ENST00000445559(transcript)|ensembl:ENST00000448594(transcript)|ensembl:ENST00000451970(transcript)|ensembl:ENST00000452658(transcript)|ensembl:ENST00000547641(transcript)|ensembl:ENST00000547952(transcript)|ensembl:ENST00000548040(transcript)|ensembl:ENST00000552711(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006457"(protein folding)|go:"GO:0016272"(prefoldin complex)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051131"(chaperone-mediated protein complex assembly)|go:"GO:1905907"(negative regulation of amyloid fibril formation)|interpro:IPR002777(Prefoldin beta-like)|interpro:IPR009053(Prefoldin)|mint:O15212|rcsb pdb:6NR8|rcsb pdb:6NR9|rcsb pdb:6NRB|rcsb pdb:6NRC|rcsb pdb:6NRD|reactome:R-HSA-389957 psi-mi:"MI:0469"(intact) - crc64:8F138EAAE512A312 figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:VwbVhr/GuqylbroxXXcpBpWAXvM9606 rogid:t7Z68vuvmprxLIGDh4JhqCGvX+A9606 intact-crc:4005DFB74B0B6633|rigid:Fgovrv4jWmoNOfiu56hccfzhp2Y false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UM82 uniprotkb:O43805 intact:EBI-744066|uniprotkb:O94857|uniprotkb:E1P626|ensembl:ENSP00000289431|ensembl:ENSP00000416799 intact:EBI-2515299|ensembl:ENSP00000313752|uniprotkb:Q9BVW8|uniprotkb:Q6FG70|uniprotkb:Q5VSG0 psi-mi:spat2_human(display_long)|uniprotkb:SPATA2(gene name)|psi-mi:SPATA2(display_short)|uniprotkb:KIAA0757(gene name synonym)|uniprotkb:PD1(gene name synonym) psi-mi:ssna1_human(display_long)|uniprotkb:SSNA1(gene name)|psi-mi:SSNA1(display_short)|uniprotkb:NA14(gene name synonym)|uniprotkb:Nuclear autoantigen of 14 kDa(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515297|imex:IM-12079-97 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001129245.1|refseq:NP_006029.1|refseq:XP_011527418.1|ensembl:ENSG00000158480(gene)|ensembl:ENST00000289431(transcript)|ensembl:ENST00000422556(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0007283"(spermatogenesis)|go:"GO:0010803"(regulation of tumor necrosis factor-mediated signaling pathway)|refseq:XP_006723957.1|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0060544"(regulation of necroptotic process)|go:"GO:0070266"(necroptotic process)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0072520"(seminiferous tubule development)|go:"GO:1990108"(protein linear deubiquitination)|go:"GO:1990381"(ubiquitin-specific protease binding)|interpro:IPR029744|mint:Q9UM82|rcsb pdb:5LJM|rcsb pdb:5LJN ensembl:ENSG00000176101(gene)|ensembl:ENST00000322310(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042073"(intraciliary transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0060830"(ciliary receptor clustering involved in smoothened signaling pathway)|interpro:IPR033362|mint:O43805|reactome:R-HSA-2565942|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-5620912|reactome:R-HSA-8854518|refseq:NP_003722.2 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:VwbVhr/GuqylbroxXXcpBpWAXvM9606 rogid:W48R8M8go89X1aS1L1AHejuOO+g9606 intact-crc:4005DFB74B0B6633|rigid:Fgovrv4jWmoNOfiu56hccfzhp2Y false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q9UM82 uniprotkb:Q96RL1 intact:EBI-744066|uniprotkb:O94857|uniprotkb:E1P626|ensembl:ENSP00000289431|ensembl:ENSP00000416799 intact:EBI-725300|intact:EBI-1263554|uniprotkb:Q5XKQ1|uniprotkb:Q7Z3W7|uniprotkb:Q8N5B9|uniprotkb:Q9BZR1|uniprotkb:Q9BZR5|uniprotkb:Q9UHX7|uniprotkb:A8MSA1|uniprotkb:B3KMZ1|uniprotkb:B4E3N2|ensembl:ENSP00000366434|ensembl:ENSP00000421926 psi-mi:spat2_human(display_long)|uniprotkb:SPATA2(gene name)|psi-mi:SPATA2(display_short)|uniprotkb:KIAA0757(gene name synonym)|uniprotkb:PD1(gene name synonym) psi-mi:uimc1_human(display_long)|uniprotkb:Retinoid X receptor-interacting protein 110(gene name synonym)|uniprotkb:Receptor-associated protein 80(gene name synonym)|uniprotkb:Ubiquitin interaction motif-containing protein 1(gene name synonym)|uniprotkb:UIMC1(gene name)|psi-mi:UIMC1(display_short)|uniprotkb:RAP80(gene name synonym)|uniprotkb:RXRIP110(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515297|imex:IM-12079-97 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001129245.1|refseq:NP_006029.1|refseq:XP_011527418.1|ensembl:ENSG00000158480(gene)|ensembl:ENST00000289431(transcript)|ensembl:ENST00000422556(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0007283"(spermatogenesis)|go:"GO:0010803"(regulation of tumor necrosis factor-mediated signaling pathway)|refseq:XP_006723957.1|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0060544"(regulation of necroptotic process)|go:"GO:0070266"(necroptotic process)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0072520"(seminiferous tubule development)|go:"GO:1990108"(protein linear deubiquitination)|go:"GO:1990381"(ubiquitin-specific protease binding)|interpro:IPR029744|mint:Q9UM82|rcsb pdb:5LJM|rcsb pdb:5LJN refseq:NP_001186226.1|refseq:NP_001186227.1|refseq:NP_057374.3|refseq:NP_001304890.1|ensembl:ENSG00000087206(gene)|ensembl:ENST00000377227(transcript)|ensembl:ENST00000511320(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006302"(double-strand break repair)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016604"(nuclear body)|go:"GO:0042393"(histone binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0070531"(BRCA1-A complex)|go:"GO:0070537"(histone H2A K63-linked deubiquitination)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR006642(Zinc finger, Rad18-type putative)|interpro:IPR038868|interpro:IPR040714|mint:Q96RL1|rcsb pdb:2MKF|rcsb pdb:2MKG|rcsb pdb:2N9E|rcsb pdb:2RR9|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473|refseq:XP_005265987.1|refseq:XP_005265993.1|refseq:XP_006714934.1|refseq:XP_016865063.1|refseq:XP_016865067.1|refseq:XP_016865068.1|dip:DIP-29936N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:VwbVhr/GuqylbroxXXcpBpWAXvM9606 rogid:j5ho+aD4tkX7bXXlROdiprUX1Mc9606 intact-crc:4005DFB74B0B6633|rigid:Fgovrv4jWmoNOfiu56hccfzhp2Y false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q15170 uniprotkb:Q96T88 intact:EBI-2511314|uniprotkb:Q9UJQ9|intact:EBI-11156070 intact:EBI-1548946|uniprotkb:Q8J022|uniprotkb:Q9H6S6|uniprotkb:Q9P115|uniprotkb:Q9P1U7|uniprotkb:A0JBR2|uniprotkb:A8K024|uniprotkb:B2RBA9|uniprotkb:Q2HIX7|ensembl:ENSP00000478348|ensembl:ENSP00000478601|ensembl:ENSP00000484739|ensembl:ENSP00000485604|ensembl:ENSP00000498698 psi-mi:tcal1_human(display_long)|uniprotkb:TCEAL1(gene name)|psi-mi:TCEAL1(display_short)|uniprotkb:SIIR(gene name synonym)|uniprotkb:Transcription elongation factor S-II protein-like 1(gene name synonym)|uniprotkb:Nuclear phosphoprotein p21/SIIR(gene name synonym) psi-mi:uhrf1_human(display_long)|uniprotkb:UHRF1(gene name)|psi-mi:UHRF1(display_short)|uniprotkb:ICBP90(gene name synonym)|uniprotkb:NP95(gene name synonym)|uniprotkb:RNF106(gene name synonym)|uniprotkb:Ubiquitin-like PHD and RING finger domain-containing protein 1(gene name synonym)|uniprotkb:Ubiquitin-like-containing PHD and RING finger domains protein 1(gene name synonym)|uniprotkb:Inverted CCAAT box-binding protein of 90 kDa(gene name synonym)|uniprotkb:Transcription factor ICBP90(gene name synonym)|uniprotkb:Nuclear zinc finger protein Np95(gene name synonym)|uniprotkb:Nuclear protein 95(gene name synonym)|uniprotkb:RING finger protein 106(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase UHRF1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515366|imex:IM-12079-47 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0050699"(WW domain binding)|interpro:IPR021156|interpro:IPR010370(Transcription elongation factor A, SII-related)|mint:Q15170 refseq:NP_001276979.1|refseq:NP_001276980.1|refseq:NP_001276981.1|refseq:NP_037414.3|refseq:NP_001041666.1|ensembl:ENSG00000276043(gene)|ensembl:ENST00000612630(transcript)|ensembl:ENST00000615884(transcript)|ensembl:ENST00000616255(transcript)|ensembl:ENST00000624301(transcript)|ensembl:ENST00000650932(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000791"(euchromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0006281"(DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007049"(cell cycle)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0010216"(maintenance of DNA methylation)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0031493"(obsolete nucleosomal histone binding)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0035064"(methylated histone binding)|go:"GO:0042393"(histone binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0044729"(hemi-methylated DNA-binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050678"(regulation of epithelial cell proliferation)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:2000373"("positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity")|interpro:IPR000626(Ubiquitin)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR003105(SRA-YDG)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR015947(PUA-like)|interpro:IPR017907|interpro:IPR019787|interpro:IPR021991|interpro:IPR029071|interpro:IPR036987|mint:Q96T88|rcsb pdb:2FAZ|rcsb pdb:2L3R|rcsb pdb:2LGG|rcsb pdb:2LGK|rcsb pdb:2LGL|rcsb pdb:2PB7|rcsb pdb:3ASK|rcsb pdb:3ASL|rcsb pdb:3BI7|rcsb pdb:3CLZ|rcsb pdb:3DB3|rcsb pdb:3DB4|rcsb pdb:3DWH|rcsb pdb:3FL2|rcsb pdb:3SHB|rcsb pdb:3SOU|rcsb pdb:3SOW|rcsb pdb:3SOX|rcsb pdb:3T6R|rcsb pdb:3ZVY|rcsb pdb:3ZVZ|rcsb pdb:4GY5|rcsb pdb:4QQD|rcsb pdb:5C6D|rcsb pdb:5IAY|rcsb pdb:5XPI|rcsb pdb:5YY9|rcsb pdb:5YYA|rcsb pdb:6B9M|rcsb pdb:6IIW|rcsb pdb:6VCS|rcsb pdb:6VED|rcsb pdb:6VYJ|rcsb pdb:6W92|reactome:R-HSA-5334118|interpro:IPR001841(Zinc finger, RING-type) psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2021/11/30 rogid:QGQDFZmacLSo79K+UBfW/ulS32E9606 rogid:AbWLjSoRl82HTcjZlG4DRavDdGc9606 intact-crc:7B25B86D64E67494|rigid:+mewbyRkDjEMqlnIQsPQmgdlEdk false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q15170 uniprotkb:O14737 intact:EBI-2511314|uniprotkb:Q9UJQ9|intact:EBI-11156070 intact:EBI-712290|ensembl:ENSP00000466214|uniprotkb:Q53YC9|uniprotkb:Q6IB70|uniprotkb:B4DE64 psi-mi:tcal1_human(display_long)|uniprotkb:TCEAL1(gene name)|psi-mi:TCEAL1(display_short)|uniprotkb:SIIR(gene name synonym)|uniprotkb:Transcription elongation factor S-II protein-like 1(gene name synonym)|uniprotkb:Nuclear phosphoprotein p21/SIIR(gene name synonym) psi-mi:pdcd5_human(display_long)|uniprotkb:TF-1 cell apoptosis-related protein 19(gene name synonym)|uniprotkb:PDCD5(gene name)|psi-mi:PDCD5(display_short)|uniprotkb:TFAR19(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515366|imex:IM-12079-47 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0050699"(WW domain binding)|interpro:IPR021156|interpro:IPR010370(Transcription elongation factor A, SII-related)|mint:Q15170 go:"GO:0010698"(acetyltransferase activator activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:1903638"(positive regulation of protein insertion into mitochondrial outer membrane)|go:"GO:1903645"(negative regulation of chaperone-mediated protein folding)|mint:O14737|rcsb pdb:1YYB|rcsb pdb:2CRU|rcsb pdb:2K6B|interpro:IPR002836(DNA-binding TFAR19-related protein)|interpro:IPR036883|ensembl:ENSG00000105185(gene)|ensembl:ENST00000590247(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0008201"(heparin binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|refseq:NP_004699.1|refseq:XP_005259449.1|dip:DIP-50602N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2021/11/30 rogid:QGQDFZmacLSo79K+UBfW/ulS32E9606 rogid:K2DZzTWT7H8gGATfyR72aXDu5qc9606 intact-crc:7B25B86D64E67494|rigid:+mewbyRkDjEMqlnIQsPQmgdlEdk false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q15170 uniprotkb:Q9BVW5 intact:EBI-2511314|uniprotkb:Q9UJQ9|intact:EBI-11156070 intact:EBI-2515360|ensembl:ENSP00000261881|uniprotkb:Q9NWZ6|uniprotkb:B2CW64 psi-mi:tcal1_human(display_long)|uniprotkb:TCEAL1(gene name)|psi-mi:TCEAL1(display_short)|uniprotkb:SIIR(gene name synonym)|uniprotkb:Transcription elongation factor S-II protein-like 1(gene name synonym)|uniprotkb:Nuclear phosphoprotein p21/SIIR(gene name synonym) psi-mi:tipin_human(display_long)|uniprotkb:TIPIN(gene name)|psi-mi:TIPIN(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515366|imex:IM-12079-47 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0050699"(WW domain binding)|interpro:IPR021156|interpro:IPR010370(Transcription elongation factor A, SII-related)|mint:Q15170 ensembl:ENSG00000075131(gene)|ensembl:ENST00000261881(transcript)|go:"GO:0000076"(DNA replication checkpoint signaling)|go:"GO:0000785"(chromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009411"(response to UV)|go:"GO:0031298"(replication fork protection complex)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0033262"(regulation of nuclear cell cycle DNA replication)|go:"GO:0043111"(replication fork arrest)|go:"GO:0044770"(cell cycle phase transition)|go:"GO:0048478"(replication fork protection)|go:"GO:0051301"(cell division)|interpro:IPR012923(Replication fork protection component Swi3)|interpro:IPR040038|reactome:R-HSA-5693607|refseq:XP_011520045.1|refseq:NP_060328.2|refseq:XP_005254578.1|refseq:XP_005254579.1|refseq:NP_001276915.1|refseq:XP_006720657.1|refseq:XP_016877879.1|dip:DIP-53658N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2021/11/30 rogid:QGQDFZmacLSo79K+UBfW/ulS32E9606 rogid:vNvUsnDmodQH/QQqJBYYSbjIdKo9606 intact-crc:7B25B86D64E67494|rigid:+mewbyRkDjEMqlnIQsPQmgdlEdk false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q15170 uniprotkb:Q9NZ48 intact:EBI-2511314|uniprotkb:Q9UJQ9|intact:EBI-11156070 intact:EBI-2515357 psi-mi:tcal1_human(display_long)|uniprotkb:TCEAL1(gene name)|psi-mi:TCEAL1(display_short)|uniprotkb:SIIR(gene name synonym)|uniprotkb:Transcription elongation factor S-II protein-like 1(gene name synonym)|uniprotkb:Nuclear phosphoprotein p21/SIIR(gene name synonym) psi-mi:q9nz48_human(display_long) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515366|imex:IM-12079-47 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0050699"(WW domain binding)|interpro:IPR021156|interpro:IPR010370(Transcription elongation factor A, SII-related)|mint:Q15170 go:"GO:0000159"(protein phosphatase type 2A complex)|go:"GO:0019888"(protein phosphatase regulator activity)|interpro:IPR000009(Protein phosphatase 2A, regulatory subunit PR55)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR036322 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2021/11/30 rogid:QGQDFZmacLSo79K+UBfW/ulS32E9606 rogid:btUhiFf3iNXB0afzHNv49Tlg6Fo9606 intact-crc:7B25B86D64E67494|rigid:+mewbyRkDjEMqlnIQsPQmgdlEdk false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q15170 uniprotkb:Q96JP0 intact:EBI-2511314|uniprotkb:Q9UJQ9|intact:EBI-11156070 intact:EBI-2515330|ensembl:ENSP00000274457|uniprotkb:B2RE47|uniprotkb:Q9NPL6|uniprotkb:Q9H704|uniprotkb:Q9NPL9|uniprotkb:Q8N3V8 psi-mi:tcal1_human(display_long)|uniprotkb:TCEAL1(gene name)|psi-mi:TCEAL1(display_short)|uniprotkb:SIIR(gene name synonym)|uniprotkb:Transcription elongation factor S-II protein-like 1(gene name synonym)|uniprotkb:Nuclear phosphoprotein p21/SIIR(gene name synonym) psi-mi:fem1c_human(display_long)|uniprotkb:FEM1C(gene name)|psi-mi:FEM1C(display_short)|uniprotkb:KIAA1785(gene name synonym)|uniprotkb:FEM1-gamma(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515366|imex:IM-12079-47 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0050699"(WW domain binding)|interpro:IPR021156|interpro:IPR010370(Transcription elongation factor A, SII-related)|mint:Q15170 ensembl:ENSG00000145780(gene)|ensembl:ENST00000274457(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0031462"(Cul2-RING ubiquitin ligase complex)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0140627"(ubiquitin-dependent protein catabolic process via the C-end degron rule pathway)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|interpro:IPR002110(Ankyrin)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR020683|interpro:IPR036770|rcsb pdb:6LBG|rcsb pdb:6LBN|rcsb pdb:6LDP|rcsb pdb:6LE6|rcsb pdb:6LEN|rcsb pdb:6LEY|rcsb pdb:6LF0|rcsb pdb:6XKC|rcsb pdb:7JYA|reactome:R-HSA-8951664|refseq:NP_064562.1|refseq:XP_005272092.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2021/11/30 rogid:QGQDFZmacLSo79K+UBfW/ulS32E9606 rogid:5UtDoD5ZL7pYpQNNELcgT+Z9lgU9606 intact-crc:7B25B86D64E67494|rigid:+mewbyRkDjEMqlnIQsPQmgdlEdk false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q15170 uniprotkb:Q96EI5 intact:EBI-2511314|uniprotkb:Q9UJQ9|intact:EBI-11156070 intact:EBI-2511291|ensembl:ENSP00000415564|ensembl:ENSP00000421156|ensembl:ENSP00000424314|ensembl:ENSP00000427494|ensembl:ENSP00000421857|uniprotkb:Q9H2H1|uniprotkb:Q9H775|uniprotkb:Q8WY12 psi-mi:tcal1_human(display_long)|uniprotkb:TCEAL1(gene name)|psi-mi:TCEAL1(display_short)|uniprotkb:SIIR(gene name synonym)|uniprotkb:Transcription elongation factor S-II protein-like 1(gene name synonym)|uniprotkb:Nuclear phosphoprotein p21/SIIR(gene name synonym) psi-mi:tcal4_human(display_long)|uniprotkb:TCEAL4(gene name)|psi-mi:TCEAL4(display_short)|uniprotkb:Transcription elongation factor S-II protein-like 4(gene name synonym)|uniprotkb:NPD017(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515366|imex:IM-12079-47 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0050699"(WW domain binding)|interpro:IPR021156|interpro:IPR010370(Transcription elongation factor A, SII-related)|mint:Q15170 ensembl:ENSG00000133142(gene)|ensembl:ENST00000415568(transcript)|ensembl:ENST00000468024(transcript)|ensembl:ENST00000472484(transcript)|ensembl:ENST00000472745(transcript)|ensembl:ENST00000494801(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0050699"(WW domain binding)|interpro:IPR021156|refseq:NP_001292769.1|refseq:NP_001292770.1|refseq:NP_001292771.1|refseq:NP_001006936.1|refseq:NP_001006938.1|refseq:NP_079139.4|refseq:NP_001287830.1|refseq:XP_016885346.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2021/11/30 rogid:QGQDFZmacLSo79K+UBfW/ulS32E9606 rogid:fR3mlHCl98Bd+Gy3XGTmmev/gRM9606 intact-crc:7B25B86D64E67494|rigid:+mewbyRkDjEMqlnIQsPQmgdlEdk false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q15170 uniprotkb:P51784 intact:EBI-2511314|uniprotkb:Q9UJQ9|intact:EBI-11156070 intact:EBI-306876|intact:EBI-1058416|uniprotkb:Q8IUG6|uniprotkb:Q9BWE1|uniprotkb:B2RTX1|ensembl:ENSP00000218348 psi-mi:tcal1_human(display_long)|uniprotkb:TCEAL1(gene name)|psi-mi:TCEAL1(display_short)|uniprotkb:SIIR(gene name synonym)|uniprotkb:Transcription elongation factor S-II protein-like 1(gene name synonym)|uniprotkb:Nuclear phosphoprotein p21/SIIR(gene name synonym) psi-mi:ubp11_human(display_long)|uniprotkb:USP11(gene name)|psi-mi:USP11(display_short)|uniprotkb:UHX1(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 11(gene name synonym)|uniprotkb:Deubiquitinating enzyme 11(gene name synonym)|uniprotkb:Ubiquitin thioesterase 11(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515366|imex:IM-12079-47 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0050699"(WW domain binding)|interpro:IPR021156|interpro:IPR010370(Transcription elongation factor A, SII-related)|mint:Q15170 ensembl:ENSG00000102226(gene)|ensembl:ENST00000218348(transcript)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR018200|interpro:IPR028135|interpro:IPR028889|interpro:IPR029346|interpro:IPR035927|interpro:IPR038765|mint:P51784|rcsb pdb:4MEL|rcsb pdb:5OK6|reactome:R-HSA-390471|reactome:R-HSA-5689880|refseq:NP_004642.2|refseq:XP_011542290.1|refseq:XP_005272731.1|dip:DIP-27567N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2021/11/30 rogid:QGQDFZmacLSo79K+UBfW/ulS32E9606 rogid:OSJLLFBf1ofw8SC01p2iiIM1oJo9606 intact-crc:7B25B86D64E67494|rigid:+mewbyRkDjEMqlnIQsPQmgdlEdk false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q15170 uniprotkb:P49915 intact:EBI-2511314|uniprotkb:Q9UJQ9|intact:EBI-11156070 intact:EBI-1050289|uniprotkb:A8K639|uniprotkb:B4DXV7|uniprotkb:F8W720|ensembl:ENSP00000419851 psi-mi:tcal1_human(display_long)|uniprotkb:TCEAL1(gene name)|psi-mi:TCEAL1(display_short)|uniprotkb:SIIR(gene name synonym)|uniprotkb:Transcription elongation factor S-II protein-like 1(gene name synonym)|uniprotkb:Nuclear phosphoprotein p21/SIIR(gene name synonym) psi-mi:guaa_human(display_long)|uniprotkb:GMP synthetase(gene name synonym)|uniprotkb:Glutamine amidotransferase(gene name synonym)|uniprotkb:GMPS(gene name)|psi-mi:GMPS(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515366|imex:IM-12079-47 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0050699"(WW domain binding)|interpro:IPR021156|interpro:IPR010370(Transcription elongation factor A, SII-related)|mint:Q15170 refseq:NP_003866.1|ensembl:ENSG00000163655(gene)|ensembl:ENST00000496455(transcript)|go:"GO:0003921"(GMP synthase activity)|go:"GO:0003922"("GMP synthase (glutamine-hydrolyzing) activity")|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006177"(GMP biosynthetic process)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0009113"(purine nucleobase biosynthetic process)|go:"GO:0009168"(purine ribonucleoside monophosphate biosynthetic process)|go:"GO:0016462"(pyrophosphatase activity)|interpro:IPR001674(GMP synthase, C-terminal)|interpro:IPR004739(GMP synthase, N-terminal)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR017926|interpro:IPR022310|interpro:IPR025777|interpro:IPR029062|mint:P49915|rcsb pdb:2VPI|rcsb pdb:2VXO|reactome:R-HSA-73817 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2021/11/30 rogid:QGQDFZmacLSo79K+UBfW/ulS32E9606 rogid:LYs65bPoqjVG/ZxA6v+yJo3HsLI9606 intact-crc:7B25B86D64E67494|rigid:+mewbyRkDjEMqlnIQsPQmgdlEdk false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q15170 uniprotkb:Q9Y4C1 intact:EBI-2511314|uniprotkb:Q9UJQ9|intact:EBI-11156070 intact:EBI-2515339|ensembl:ENSP00000323659|ensembl:ENSP00000386516|ensembl:ENSP00000386660|uniprotkb:Q68UT9|uniprotkb:Q8IY08|uniprotkb:Q68D47|uniprotkb:Q53S72|uniprotkb:Q6N050|uniprotkb:D6W5M3 psi-mi:tcal1_human(display_long)|uniprotkb:TCEAL1(gene name)|psi-mi:TCEAL1(display_short)|uniprotkb:SIIR(gene name synonym)|uniprotkb:Transcription elongation factor S-II protein-like 1(gene name synonym)|uniprotkb:Nuclear phosphoprotein p21/SIIR(gene name synonym) psi-mi:kdm3a_human(display_long)|uniprotkb:KDM3A(gene name)|psi-mi:KDM3A(display_short)|uniprotkb:JHDM2A(gene name synonym)|uniprotkb:JMJD1(gene name synonym)|uniprotkb:JMJD1A(gene name synonym)|uniprotkb:KIAA0742(gene name synonym)|uniprotkb:TSGA(gene name synonym)|uniprotkb:JmjC domain-containing histone demethylation protein 2A(gene name synonym)|uniprotkb:Jumonji domain-containing protein 1A(gene name synonym)|uniprotkb:"[histone H3]-dimethyl-L-lysine(9) demethylase 3A"(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515366|imex:IM-12079-47 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0050699"(WW domain binding)|interpro:IPR021156|interpro:IPR010370(Transcription elongation factor A, SII-related)|mint:Q15170 ensembl:ENSG00000115548(gene)|ensembl:ENST00000312912(transcript)|ensembl:ENST00000409064(transcript)|ensembl:ENST00000409556(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005506"(iron ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0000785"(chromatin)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007290"(spermatid nucleus elongation)|go:"GO:0009755"(hormone-mediated signaling pathway)|go:"GO:0016020"(membrane)|go:"GO:0030521"(androgen receptor signaling pathway)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0032454"(histone H3-methyl-lysine-9 demethylase activity)|go:"GO:0033169"(histone H3-K9 demethylation)|go:"GO:0036123"(histone H3-K9 dimethylation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046293"(formaldehyde biosynthetic process)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0051213"(dioxygenase activity)|go:"GO:0051573"(negative regulation of histone H3-K9 methylation)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:2000036"(regulation of stem cell population maintenance)|go:"GO:2000736"(regulation of stem cell differentiation)|interpro:IPR003347(Transcription factor jumonji/aspartyl beta-hydroxylase)|mint:Q9Y4C1|reactome:R-HSA-3214842|reactome:R-HSA-9029569|refseq:NP_001140160.1|refseq:NP_060903.2|refseq:XP_016859982.1|dip:DIP-53661N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2021/11/30 rogid:QGQDFZmacLSo79K+UBfW/ulS32E9606 rogid:XF6xqiiGohV0b2e/bzVx+J0XH7I9606 intact-crc:7B25B86D64E67494|rigid:+mewbyRkDjEMqlnIQsPQmgdlEdk false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q15170 uniprotkb:Q13617 intact:EBI-2511314|uniprotkb:Q9UJQ9|intact:EBI-11156070 intact:EBI-456179|uniprotkb:O00200|uniprotkb:Q5T2B6|uniprotkb:Q9UNF9|uniprotkb:D3DRY6|uniprotkb:B3KT95|uniprotkb:B7Z6K8|uniprotkb:G3V1S2|ensembl:ENSP00000363881|ensembl:ENSP00000363883|ensembl:ENSP00000501215|ensembl:ENSP00000363880 psi-mi:tcal1_human(display_long)|uniprotkb:TCEAL1(gene name)|psi-mi:TCEAL1(display_short)|uniprotkb:SIIR(gene name synonym)|uniprotkb:Transcription elongation factor S-II protein-like 1(gene name synonym)|uniprotkb:Nuclear phosphoprotein p21/SIIR(gene name synonym) psi-mi:cul2_human(display_long)|uniprotkb:CUL2(gene name)|psi-mi:CUL2(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515366|imex:IM-12079-47 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0050699"(WW domain binding)|interpro:IPR021156|interpro:IPR010370(Transcription elongation factor A, SII-related)|mint:Q15170 refseq:NP_001185706.1|refseq:NP_001185707.1|refseq:NP_001185708.1|refseq:NP_003582.2|refseq:XP_011518049.1|dip:DIP-31612N|ensembl:ENST00000374748(transcript)|ensembl:ENST00000374749(transcript)|ensembl:ENST00000374751(transcript)|ensembl:ENST00000673636(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0030891"(VCB complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031462"(Cul2-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|interpro:IPR001373(Cullin, N-terminal region)|interpro:IPR016157(Cullin, conserved site)|interpro:IPR016158(Cullin homology)|interpro:IPR016159(Cullin repeat-like)|interpro:IPR019559|interpro:IPR036317|interpro:IPR036388|interpro:IPR036390|mint:Q13617|rcsb pdb:4WQO|rcsb pdb:5N4W|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|rcsb pdb:6R7N|reactome:R-HSA-1234176|reactome:R-HSA-8951664|ensembl:ENSG00000108094(gene)|reactome:R-HSA-983168|reactome:R-HSA-9010553 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2021/11/30 rogid:QGQDFZmacLSo79K+UBfW/ulS32E9606 rogid:ffttNV1NYH8UnmbHxf+ygcIG1wE9606 intact-crc:7B25B86D64E67494|rigid:+mewbyRkDjEMqlnIQsPQmgdlEdk false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q15170 uniprotkb:Q9BSK4 intact:EBI-2511314|uniprotkb:Q9UJQ9|intact:EBI-11156070 intact:EBI-2515349|ensembl:ENSP00000269856|uniprotkb:Q9NPW8|uniprotkb:Q9NPN7|uniprotkb:Q711P8|uniprotkb:B2RDI3 psi-mi:tcal1_human(display_long)|uniprotkb:TCEAL1(gene name)|psi-mi:TCEAL1(display_short)|uniprotkb:SIIR(gene name synonym)|uniprotkb:Transcription elongation factor S-II protein-like 1(gene name synonym)|uniprotkb:Nuclear phosphoprotein p21/SIIR(gene name synonym) psi-mi:fem1a_human(display_long)|uniprotkb:FEM1A(gene name)|psi-mi:FEM1A(display_short)|uniprotkb:EPRAP(gene name synonym)|uniprotkb:FEM1-alpha(gene name synonym)|uniprotkb:Prostaglandin E receptor 4-associated protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515366|imex:IM-12079-47 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0050699"(WW domain binding)|interpro:IPR021156|interpro:IPR010370(Transcription elongation factor A, SII-related)|mint:Q15170 ensembl:ENSG00000141965(gene)|ensembl:ENST00000269856(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0031462"(Cul2-RING ubiquitin ligase complex)|go:"GO:0031867"(EP4 subtype prostaglandin E2 receptor binding)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051438"(regulation of ubiquitin-protein transferase activity)|go:"GO:0140627"(ubiquitin-dependent protein catabolic process via the C-end degron rule pathway)|go:"GO:1990756"(ubiquitin ligase-substrate adaptor activity)|interpro:IPR002110(Ankyrin)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR020683|interpro:IPR036770|reactome:R-HSA-8951664|refseq:NP_061178.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2021/11/30 rogid:QGQDFZmacLSo79K+UBfW/ulS32E9606 rogid:z4HmE8rEYWTLn/hLDQEZueK3FJI9606 intact-crc:7B25B86D64E67494|rigid:+mewbyRkDjEMqlnIQsPQmgdlEdk false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q15170 uniprotkb:Q93009 intact:EBI-2511314|uniprotkb:Q9UJQ9|intact:EBI-11156070 intact:EBI-302474|uniprotkb:A6NMY8|intact:EBI-28988230|ensembl:ENSP00000343535|uniprotkb:B7Z815|uniprotkb:H0Y3G8 psi-mi:tcal1_human(display_long)|uniprotkb:TCEAL1(gene name)|psi-mi:TCEAL1(display_short)|uniprotkb:SIIR(gene name synonym)|uniprotkb:Transcription elongation factor S-II protein-like 1(gene name synonym)|uniprotkb:Nuclear phosphoprotein p21/SIIR(gene name synonym) psi-mi:ubp7_human(display_long)|uniprotkb:USP7(gene name)|psi-mi:USP7(display_short)|uniprotkb:HAUSP(gene name synonym)|uniprotkb:Ubiquitin thioesterase 7(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 7(gene name synonym)|uniprotkb:Deubiquitinating enzyme 7(gene name synonym)|uniprotkb:Herpesvirus-associated ubiquitin-specific protease(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515366|imex:IM-12079-47 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0050699"(WW domain binding)|interpro:IPR021156|interpro:IPR010370(Transcription elongation factor A, SII-related)|mint:Q15170 rcsb pdb:4PYZ|rcsb pdb:4WPH|rcsb pdb:4WPI|rcsb pdb:4YOC|rcsb pdb:4YSI|rcsb pdb:4Z96|rcsb pdb:4Z97|rcsb pdb:5C56|rcsb pdb:5C6D|rcsb pdb:5FWI|rcsb pdb:5GG4|rcsb pdb:5J7T|rcsb pdb:5JTJ|rcsb pdb:5JTV|rcsb pdb:5KYB|rcsb pdb:4M5X|rcsb pdb:5KYC|rcsb pdb:5KYD|rcsb pdb:5KYE|rcsb pdb:5KYF|interpro:IPR029346|interpro:IPR038765|mint:Q93009|rcsb pdb:1NB8|rcsb pdb:1NBF|rcsb pdb:1YY6|rcsb pdb:1YZE|rcsb pdb:2F1W|rcsb pdb:2F1X|rcsb pdb:2F1Y|rcsb pdb:2F1Z|rcsb pdb:2FOJ|rcsb pdb:2FOO|rcsb pdb:2FOP|rcsb pdb:2KVR|rcsb pdb:2XXN|rcsb pdb:2YLM|rcsb pdb:3MQR|rcsb pdb:3MQS|rcsb pdb:4JJQ|rcsb pdb:4KG9|rcsb pdb:4M5W|go:"GO:0006283"(transcription-coupled nucleotide-excision repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010216"(maintenance of DNA methylation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035520"(monoubiquitinated protein deubiquitination)|go:"GO:0035616"(histone H2B conserved C-terminal lysine deubiquitination)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0048511"(rhythmic process)|go:"GO:0050821"(protein stabilization)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0101005"(deubiquitinase activity)|go:"GO:1901537"(positive regulation of DNA demethylation)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1904353"(regulation of telomere capping)|go:"GO:1905279"(regulation of retrograde transport, endosome to Golgi)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR018200|interpro:IPR024729|interpro:IPR028889|ensembl:ENSG00000187555(gene)|ensembl:ENST00000344836(transcript)|go:"GO:0002039"(p53 binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0006111"(regulation of gluconeogenesis)|rcsb pdb:5N9R|rcsb pdb:5N9T|rcsb pdb:5NGE|rcsb pdb:5NGF|rcsb pdb:5UQV|rcsb pdb:5UQX|rcsb pdb:5VS6|rcsb pdb:5VSB|rcsb pdb:5VSK|rcsb pdb:5WHC|rcsb pdb:6F5H|rcsb pdb:6M1K|rcsb pdb:6P5L|rcsb pdb:6VN2|rcsb pdb:6VN3|rcsb pdb:6VN4|rcsb pdb:6VN5|rcsb pdb:6VN6|rcsb pdb:7CM2|reactome:R-HSA-5689880|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6804757|reactome:R-HSA-8866652|reactome:R-HSA-8948747|refseq:NP_001273386.1|refseq:NP_003461.2|refseq:NP_001308787.1|ensembl:ENSP00000343535|ensembl:ENST00000381886|ensembl:ENSP00000371310|dip:DIP-29053N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2021/11/30 rogid:QGQDFZmacLSo79K+UBfW/ulS32E9606 rogid:V+PXXBRM2zwlGQaeFiyjaQ9yf+A9606 intact-crc:7B25B86D64E67494|rigid:+mewbyRkDjEMqlnIQsPQmgdlEdk false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q15170 uniprotkb:Q9H3H9 intact:EBI-2511314|uniprotkb:Q9UJQ9|intact:EBI-11156070 intact:EBI-2511339|ensembl:ENSP00000332359|ensembl:ENSP00000361866|uniprotkb:B2R5C7 psi-mi:tcal1_human(display_long)|uniprotkb:TCEAL1(gene name)|psi-mi:TCEAL1(display_short)|uniprotkb:SIIR(gene name synonym)|uniprotkb:Transcription elongation factor S-II protein-like 1(gene name synonym)|uniprotkb:Nuclear phosphoprotein p21/SIIR(gene name synonym) psi-mi:tcal2_human(display_long)|uniprotkb:TCEAL2(gene name)|psi-mi:TCEAL2(display_short)|uniprotkb:Transcription elongation factor S-II protein-like 2(gene name synonym)|uniprotkb:My048(orf name)|uniprotkb:MY0876G0(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515366|imex:IM-12079-47 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0050699"(WW domain binding)|interpro:IPR021156|interpro:IPR010370(Transcription elongation factor A, SII-related)|mint:Q15170 ensembl:ENSG00000184905(gene)|ensembl:ENST00000329035(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0050699"(WW domain binding)|interpro:IPR021156|ensembl:ENST00000372780(transcript)|refseq:NP_525129.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2021/11/30 rogid:QGQDFZmacLSo79K+UBfW/ulS32E9606 rogid:BWeVHwMqsKSxoC6cxyUUSika3Cc9606 intact-crc:7B25B86D64E67494|rigid:+mewbyRkDjEMqlnIQsPQmgdlEdk false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q15170 uniprotkb:Q15369 intact:EBI-2511314|uniprotkb:Q9UJQ9|intact:EBI-11156070 intact:EBI-301231|uniprotkb:Q567Q6|ensembl:ENSP00000284811|ensembl:ENSP00000428074|ensembl:ENSP00000428171|ensembl:ENSP00000428334|ensembl:ENSP00000429596|ensembl:ENSP00000429906|ensembl:ENSP00000478121|uniprotkb:E5RGD9 psi-mi:tcal1_human(display_long)|uniprotkb:TCEAL1(gene name)|psi-mi:TCEAL1(display_short)|uniprotkb:SIIR(gene name synonym)|uniprotkb:Transcription elongation factor S-II protein-like 1(gene name synonym)|uniprotkb:Nuclear phosphoprotein p21/SIIR(gene name synonym) psi-mi:eloc_human(display_long)|uniprotkb:ELOC(gene name)|psi-mi:ELOC(display_short)|uniprotkb:Elongin 15 kDa subunit(gene name synonym)|uniprotkb:RNA polymerase II transcription factor SIII subunit C(gene name synonym)|uniprotkb:SIII p15(gene name synonym)|uniprotkb:TCEB1(gene name synonym)|uniprotkb:Transcription elongation factor B polypeptide 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515366|imex:IM-12079-47 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0050699"(WW domain binding)|interpro:IPR021156|interpro:IPR010370(Transcription elongation factor A, SII-related)|mint:Q15170 refseq:NP_005639.1|refseq:NP_001191786.1|refseq:NP_001191787.1|refseq:NP_001191788.1|refseq:NP_001191789.1|refseq:NP_001191790.1|refseq:NP_001191791.1|refseq:NP_001191792.1|refseq:NP_001191793.1|ensembl:ENSG00000154582(gene)|ensembl:ENST00000284811(transcript)|ensembl:ENST00000518127(transcript)|ensembl:ENST00000519487(transcript)|ensembl:ENST00000520242(transcript)|ensembl:ENST00000522337(transcript)|ensembl:ENST00000523815(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0031462"(Cul2-RING ubiquitin ligase complex)|go:"GO:0070449"(elongin complex)|interpro:IPR001232(SKP1 component)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR016073(SKP1 component, POZ)|interpro:IPR039948|mint:Q15369|rcsb pdb:1LM8|rcsb pdb:1LQB|rcsb pdb:1VCB|rcsb pdb:2C9W|rcsb pdb:2IZV|rcsb pdb:2MA9|rcsb pdb:3DCG|rcsb pdb:3ZKJ|rcsb pdb:3ZNG|rcsb pdb:3ZRC|rcsb pdb:3ZRF|rcsb pdb:3ZTC|rcsb pdb:3ZTD|rcsb pdb:3ZUN|rcsb pdb:4AJY|rcsb pdb:4AWJ|ensembl:ENST00000622804(transcript)|rcsb pdb:4B95|rcsb pdb:4B9K|rcsb pdb:4BKS|rcsb pdb:4BKT|rcsb pdb:4N9F|rcsb pdb:4W9C|rcsb pdb:4W9D|rcsb pdb:4W9E|rcsb pdb:4W9F|rcsb pdb:4W9G|rcsb pdb:4W9H|rcsb pdb:4W9I|rcsb pdb:4W9J|rcsb pdb:4W9K|rcsb pdb:4W9L|rcsb pdb:4WQO|rcsb pdb:5BO4|rcsb pdb:5LLI|rcsb pdb:5N4W|rcsb pdb:5NVV|rcsb pdb:5NVW|rcsb pdb:5NVX|rcsb pdb:5NVY|rcsb pdb:5NVZ|rcsb pdb:5NW0|rcsb pdb:5NW1|rcsb pdb:5NW2|rcsb pdb:5T35|rcsb pdb:6BVB|rcsb pdb:6C5X|rcsb pdb:6FMI|rcsb pdb:6FMJ|rcsb pdb:6FMK|rcsb pdb:6GFX|rcsb pdb:6GFZ|rcsb pdb:6GMN|rcsb pdb:6GMQ|rcsb pdb:6GMR|rcsb pdb:6GMX|rcsb pdb:6HAX|rcsb pdb:6GFY|rcsb pdb:6HAY|rcsb pdb:6HR2|rcsb pdb:6I4X|rcsb pdb:6I5J|rcsb pdb:6I5N|rcsb pdb:6I7R|rcsb pdb:6P59|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7N|rcsb pdb:6SIS|rcsb pdb:6V9H|rcsb pdb:6ZHC|rcsb pdb:7KHH|reactome:R-HSA-112382|reactome:R-HSA-1234176|reactome:R-HSA-167152|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-180585|reactome:R-HSA-674695|reactome:R-HSA-6796648|reactome:R-HSA-75955|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9705462|reactome:R-HSA-983168|reactome:R-HSA-167200|refseq:XP_011515882.1|refseq:XP_011515883.1|dip:DIP-29571N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2021/11/30 rogid:QGQDFZmacLSo79K+UBfW/ulS32E9606 rogid:Ngvkh3YoddZoutF3Vgwdi2b6xz49606 intact-crc:7B25B86D64E67494|rigid:+mewbyRkDjEMqlnIQsPQmgdlEdk false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96EI5 uniprotkb:Q9H3H9 intact:EBI-2511291|ensembl:ENSP00000415564|ensembl:ENSP00000421156|ensembl:ENSP00000424314|ensembl:ENSP00000427494|ensembl:ENSP00000421857|uniprotkb:Q9H2H1|uniprotkb:Q9H775|uniprotkb:Q8WY12 intact:EBI-2511339|ensembl:ENSP00000332359|ensembl:ENSP00000361866|uniprotkb:B2R5C7 psi-mi:tcal4_human(display_long)|uniprotkb:TCEAL4(gene name)|psi-mi:TCEAL4(display_short)|uniprotkb:Transcription elongation factor S-II protein-like 4(gene name synonym)|uniprotkb:NPD017(orf name) psi-mi:tcal2_human(display_long)|uniprotkb:TCEAL2(gene name)|psi-mi:TCEAL2(display_short)|uniprotkb:Transcription elongation factor S-II protein-like 2(gene name synonym)|uniprotkb:My048(orf name)|uniprotkb:MY0876G0(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515402|imex:IM-12079-98 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000133142(gene)|ensembl:ENST00000415568(transcript)|ensembl:ENST00000468024(transcript)|ensembl:ENST00000472484(transcript)|ensembl:ENST00000472745(transcript)|ensembl:ENST00000494801(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0050699"(WW domain binding)|interpro:IPR021156|refseq:NP_001292769.1|refseq:NP_001292770.1|refseq:NP_001292771.1|refseq:NP_001006936.1|refseq:NP_001006938.1|refseq:NP_079139.4|refseq:NP_001287830.1|refseq:XP_016885346.1 ensembl:ENSG00000184905(gene)|ensembl:ENST00000329035(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0050699"(WW domain binding)|interpro:IPR021156|ensembl:ENST00000372780(transcript)|refseq:NP_525129.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:fR3mlHCl98Bd+Gy3XGTmmev/gRM9606 rogid:BWeVHwMqsKSxoC6cxyUUSika3Cc9606 intact-crc:EDB8B424C5B20DAC|rigid:zrDgKTrDMeIDRr5VuSF4jMaKFQQ false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96EI5 uniprotkb:Q93009 intact:EBI-2511291|ensembl:ENSP00000415564|ensembl:ENSP00000421156|ensembl:ENSP00000424314|ensembl:ENSP00000427494|ensembl:ENSP00000421857|uniprotkb:Q9H2H1|uniprotkb:Q9H775|uniprotkb:Q8WY12 intact:EBI-302474|uniprotkb:A6NMY8|intact:EBI-28988230|ensembl:ENSP00000343535|uniprotkb:B7Z815|uniprotkb:H0Y3G8 psi-mi:tcal4_human(display_long)|uniprotkb:TCEAL4(gene name)|psi-mi:TCEAL4(display_short)|uniprotkb:Transcription elongation factor S-II protein-like 4(gene name synonym)|uniprotkb:NPD017(orf name) psi-mi:ubp7_human(display_long)|uniprotkb:USP7(gene name)|psi-mi:USP7(display_short)|uniprotkb:HAUSP(gene name synonym)|uniprotkb:Ubiquitin thioesterase 7(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 7(gene name synonym)|uniprotkb:Deubiquitinating enzyme 7(gene name synonym)|uniprotkb:Herpesvirus-associated ubiquitin-specific protease(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515402|imex:IM-12079-98 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000133142(gene)|ensembl:ENST00000415568(transcript)|ensembl:ENST00000468024(transcript)|ensembl:ENST00000472484(transcript)|ensembl:ENST00000472745(transcript)|ensembl:ENST00000494801(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0050699"(WW domain binding)|interpro:IPR021156|refseq:NP_001292769.1|refseq:NP_001292770.1|refseq:NP_001292771.1|refseq:NP_001006936.1|refseq:NP_001006938.1|refseq:NP_079139.4|refseq:NP_001287830.1|refseq:XP_016885346.1 rcsb pdb:4PYZ|rcsb pdb:4WPH|rcsb pdb:4WPI|rcsb pdb:4YOC|rcsb pdb:4YSI|rcsb pdb:4Z96|rcsb pdb:4Z97|rcsb pdb:5C56|rcsb pdb:5C6D|rcsb pdb:5FWI|rcsb pdb:5GG4|rcsb pdb:5J7T|rcsb pdb:5JTJ|rcsb pdb:5JTV|rcsb pdb:5KYB|rcsb pdb:4M5X|rcsb pdb:5KYC|rcsb pdb:5KYD|rcsb pdb:5KYE|rcsb pdb:5KYF|interpro:IPR029346|interpro:IPR038765|mint:Q93009|rcsb pdb:1NB8|rcsb pdb:1NBF|rcsb pdb:1YY6|rcsb pdb:1YZE|rcsb pdb:2F1W|rcsb pdb:2F1X|rcsb pdb:2F1Y|rcsb pdb:2F1Z|rcsb pdb:2FOJ|rcsb pdb:2FOO|rcsb pdb:2FOP|rcsb pdb:2KVR|rcsb pdb:2XXN|rcsb pdb:2YLM|rcsb pdb:3MQR|rcsb pdb:3MQS|rcsb pdb:4JJQ|rcsb pdb:4KG9|rcsb pdb:4M5W|go:"GO:0006283"(transcription-coupled nucleotide-excision repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010216"(maintenance of DNA methylation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035520"(monoubiquitinated protein deubiquitination)|go:"GO:0035616"(histone H2B conserved C-terminal lysine deubiquitination)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0048511"(rhythmic process)|go:"GO:0050821"(protein stabilization)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0101005"(deubiquitinase activity)|go:"GO:1901537"(positive regulation of DNA demethylation)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1904353"(regulation of telomere capping)|go:"GO:1905279"(regulation of retrograde transport, endosome to Golgi)|go:"GO:1990380"(Lys48-specific deubiquitinase activity)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR018200|interpro:IPR024729|interpro:IPR028889|ensembl:ENSG00000187555(gene)|ensembl:ENST00000344836(transcript)|go:"GO:0002039"(p53 binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0006111"(regulation of gluconeogenesis)|rcsb pdb:5N9R|rcsb pdb:5N9T|rcsb pdb:5NGE|rcsb pdb:5NGF|rcsb pdb:5UQV|rcsb pdb:5UQX|rcsb pdb:5VS6|rcsb pdb:5VSB|rcsb pdb:5VSK|rcsb pdb:5WHC|rcsb pdb:6F5H|rcsb pdb:6M1K|rcsb pdb:6P5L|rcsb pdb:6VN2|rcsb pdb:6VN3|rcsb pdb:6VN4|rcsb pdb:6VN5|rcsb pdb:6VN6|rcsb pdb:7CM2|reactome:R-HSA-5689880|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6804757|reactome:R-HSA-8866652|reactome:R-HSA-8948747|refseq:NP_001273386.1|refseq:NP_003461.2|refseq:NP_001308787.1|ensembl:ENSP00000343535|ensembl:ENST00000381886|ensembl:ENSP00000371310|dip:DIP-29053N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:fR3mlHCl98Bd+Gy3XGTmmev/gRM9606 rogid:V+PXXBRM2zwlGQaeFiyjaQ9yf+A9606 intact-crc:EDB8B424C5B20DAC|rigid:zrDgKTrDMeIDRr5VuSF4jMaKFQQ false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96EI5 uniprotkb:P51784 intact:EBI-2511291|ensembl:ENSP00000415564|ensembl:ENSP00000421156|ensembl:ENSP00000424314|ensembl:ENSP00000427494|ensembl:ENSP00000421857|uniprotkb:Q9H2H1|uniprotkb:Q9H775|uniprotkb:Q8WY12 intact:EBI-306876|intact:EBI-1058416|uniprotkb:Q8IUG6|uniprotkb:Q9BWE1|uniprotkb:B2RTX1|ensembl:ENSP00000218348 psi-mi:tcal4_human(display_long)|uniprotkb:TCEAL4(gene name)|psi-mi:TCEAL4(display_short)|uniprotkb:Transcription elongation factor S-II protein-like 4(gene name synonym)|uniprotkb:NPD017(orf name) psi-mi:ubp11_human(display_long)|uniprotkb:USP11(gene name)|psi-mi:USP11(display_short)|uniprotkb:UHX1(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 11(gene name synonym)|uniprotkb:Deubiquitinating enzyme 11(gene name synonym)|uniprotkb:Ubiquitin thioesterase 11(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515402|imex:IM-12079-98 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000133142(gene)|ensembl:ENST00000415568(transcript)|ensembl:ENST00000468024(transcript)|ensembl:ENST00000472484(transcript)|ensembl:ENST00000472745(transcript)|ensembl:ENST00000494801(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0050699"(WW domain binding)|interpro:IPR021156|refseq:NP_001292769.1|refseq:NP_001292770.1|refseq:NP_001292771.1|refseq:NP_001006936.1|refseq:NP_001006938.1|refseq:NP_079139.4|refseq:NP_001287830.1|refseq:XP_016885346.1 ensembl:ENSG00000102226(gene)|ensembl:ENST00000218348(transcript)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR006615(Ubiquitin carboxyl-terminal hydrolase, N-terminal region 1)|interpro:IPR018200|interpro:IPR028135|interpro:IPR028889|interpro:IPR029346|interpro:IPR035927|interpro:IPR038765|mint:P51784|rcsb pdb:4MEL|rcsb pdb:5OK6|reactome:R-HSA-390471|reactome:R-HSA-5689880|refseq:NP_004642.2|refseq:XP_011542290.1|refseq:XP_005272731.1|dip:DIP-27567N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:fR3mlHCl98Bd+Gy3XGTmmev/gRM9606 rogid:OSJLLFBf1ofw8SC01p2iiIM1oJo9606 intact-crc:EDB8B424C5B20DAC|rigid:zrDgKTrDMeIDRr5VuSF4jMaKFQQ false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96RL1 uniprotkb:P35249 intact:EBI-725300|intact:EBI-1263554|uniprotkb:Q5XKQ1|uniprotkb:Q7Z3W7|uniprotkb:Q8N5B9|uniprotkb:Q9BZR1|uniprotkb:Q9BZR5|uniprotkb:Q9UHX7|uniprotkb:A8MSA1|uniprotkb:B3KMZ1|uniprotkb:B4E3N2|ensembl:ENSP00000366434|ensembl:ENSP00000421926 intact:EBI-476655|uniprotkb:Q6FHX7|ensembl:ENSP00000296273|ensembl:ENSP00000376272|uniprotkb:D3DNV2|uniprotkb:B4DM41 psi-mi:uimc1_human(display_long)|uniprotkb:Retinoid X receptor-interacting protein 110(gene name synonym)|uniprotkb:Receptor-associated protein 80(gene name synonym)|uniprotkb:Ubiquitin interaction motif-containing protein 1(gene name synonym)|uniprotkb:UIMC1(gene name)|psi-mi:UIMC1(display_short)|uniprotkb:RAP80(gene name synonym)|uniprotkb:RXRIP110(gene name synonym) psi-mi:rfc4_human(display_long)|uniprotkb:Activator 1 subunit 4(gene name synonym)|uniprotkb:Replication factor C 37 kDa subunit(gene name synonym)|uniprotkb:Activator 1 37 kDa subunit(gene name synonym)|uniprotkb:RFC4(gene name)|psi-mi:RFC4(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515432|imex:IM-12079-48 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001186226.1|refseq:NP_001186227.1|refseq:NP_057374.3|refseq:NP_001304890.1|ensembl:ENSG00000087206(gene)|ensembl:ENST00000377227(transcript)|ensembl:ENST00000511320(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006302"(double-strand break repair)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016604"(nuclear body)|go:"GO:0042393"(histone binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0070531"(BRCA1-A complex)|go:"GO:0070537"(histone H2A K63-linked deubiquitination)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR006642(Zinc finger, Rad18-type putative)|interpro:IPR038868|interpro:IPR040714|mint:Q96RL1|rcsb pdb:2MKF|rcsb pdb:2MKG|rcsb pdb:2N9E|rcsb pdb:2RR9|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473|refseq:XP_005265987.1|refseq:XP_005265993.1|refseq:XP_006714934.1|refseq:XP_016865063.1|refseq:XP_016865067.1|refseq:XP_016865068.1|dip:DIP-29936N refseq:NP_002907.1|refseq:NP_853551.1|go:"GO:0003677"(DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|ensembl:ENSG00000163918(gene)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005663"(DNA replication factor C complex)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0006271"(DNA strand elongation involved in DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0031390"(Ctf18 RFC-like complex)|go:"GO:0031391"(Elg1 RFC-like complex)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:1900264"(positive regulation of DNA-directed DNA polymerase activity)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR008921(DNA polymerase III clamp loader subunit, C-terminal)|interpro:IPR013748(Replication factor C)|interpro:IPR027417|ensembl:ENST00000296273(transcript)|ensembl:ENST00000392481(transcript)|mint:P35249|rcsb pdb:6VVO|reactome:R-HSA-110312|reactome:R-HSA-110314|reactome:R-HSA-110320|reactome:R-HSA-174411|reactome:R-HSA-5651801|reactome:R-HSA-5655862|reactome:R-HSA-5656121|reactome:R-HSA-5656169|reactome:R-HSA-5685938|reactome:R-HSA-5685942|reactome:R-HSA-5693607|reactome:R-HSA-5693616|reactome:R-HSA-5696397|reactome:R-HSA-5696400|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6804756|reactome:R-HSA-69091|reactome:R-HSA-69473|reactome:R-HSA-176187|dip:DIP-24267N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/10/11 rogid:j5ho+aD4tkX7bXXlROdiprUX1Mc9606 rogid:zn+V998ZRpYIdHmG87ExC6LFc0w9606 intact-crc:9F72FD50BF55E39F|rigid:bV4m56+z4dSFYYaXgpVyRQsWti0 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96RL1 uniprotkb:O14936 intact:EBI-725300|intact:EBI-1263554|uniprotkb:Q5XKQ1|uniprotkb:Q7Z3W7|uniprotkb:Q8N5B9|uniprotkb:Q9BZR1|uniprotkb:Q9BZR5|uniprotkb:Q9UHX7|uniprotkb:A8MSA1|uniprotkb:B3KMZ1|uniprotkb:B4E3N2|ensembl:ENSP00000366434|ensembl:ENSP00000421926 intact:EBI-1215506|uniprotkb:Q5VT18|uniprotkb:Q5VT19|uniprotkb:Q66T42|uniprotkb:A6NES1|uniprotkb:O43215|uniprotkb:Q17RI4|uniprotkb:Q59HA0|uniprotkb:Q5VT16|uniprotkb:Q5VT17|uniprotkb:Q9BYH6|uniprotkb:Q9NYB2|uniprotkb:Q9NYB3|uniprotkb:B7ZKY0|ensembl:ENSP00000367405 psi-mi:uimc1_human(display_long)|uniprotkb:Retinoid X receptor-interacting protein 110(gene name synonym)|uniprotkb:Receptor-associated protein 80(gene name synonym)|uniprotkb:Ubiquitin interaction motif-containing protein 1(gene name synonym)|uniprotkb:UIMC1(gene name)|psi-mi:UIMC1(display_short)|uniprotkb:RAP80(gene name synonym)|uniprotkb:RXRIP110(gene name synonym) psi-mi:cskp_human(display_long)|uniprotkb:CASK(gene name)|psi-mi:CASK(display_short)|uniprotkb:LIN2(gene name synonym)|uniprotkb:Calcium/calmodulin-dependent serine protein kinase(gene name synonym)|uniprotkb:Protein lin-2 homolog(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515432|imex:IM-12079-48 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001186226.1|refseq:NP_001186227.1|refseq:NP_057374.3|refseq:NP_001304890.1|ensembl:ENSG00000087206(gene)|ensembl:ENST00000377227(transcript)|ensembl:ENST00000511320(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006302"(double-strand break repair)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016604"(nuclear body)|go:"GO:0042393"(histone binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0070531"(BRCA1-A complex)|go:"GO:0070537"(histone H2A K63-linked deubiquitination)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR006642(Zinc finger, Rad18-type putative)|interpro:IPR038868|interpro:IPR040714|mint:Q96RL1|rcsb pdb:2MKF|rcsb pdb:2MKG|rcsb pdb:2N9E|rcsb pdb:2RR9|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473|refseq:XP_005265987.1|refseq:XP_005265993.1|refseq:XP_006714934.1|refseq:XP_016865063.1|refseq:XP_016865067.1|refseq:XP_016865068.1|dip:DIP-29936N refseq:NP_001119526.1|refseq:NP_001119527.1|refseq:NP_003679.2|dip:DIP-38727N|ensembl:ENSG00000147044(gene)|ensembl:ENST00000378163(transcript)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0004385"(guanylate kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005604"(basement membrane)|go:"GO:0005652"(nuclear lamina)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007155"(cell adhesion)|go:"GO:0010839"(negative regulation of keratinocyte proliferation)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016363"(nuclear matrix)|go:"GO:0031982"(vesicle)|go:"GO:0042043"(neurexin family protein binding)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0060170"(ciliary membrane)|go:"GO:0061045"(negative regulation of wound healing)|go:"GO:0070509"(calcium ion import)|go:"GO:0090280"(positive regulation of calcium ion import)|go:"GO:0090288"(negative regulation of cellular response to growth factor stimulus)|rcsb pdb:3MFT|rcsb pdb:3MFU|rcsb pdb:3TAC|rcsb pdb:6KMH|rcsb pdb:7OAI|rcsb pdb:7OAJ|rcsb pdb:7OAK|rcsb pdb:7OAL|reactome:R-HSA-212676|reactome:R-HSA-3000170|reactome:R-HSA-373753|reactome:R-HSA-6794361|reactome:R-HSA-9609736|reactome:R-HSA-9662360|reactome:R-HSA-9662361|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001452(Src homology-3)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR004172(L27)|interpro:IPR008144(Guanylate kinase)|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR011009(Protein kinase-like)|interpro:IPR014775(L27, C-terminal)|interpro:IPR020590|interpro:IPR027417|interpro:IPR035473|interpro:IPR036028|interpro:IPR036034|interpro:IPR036892|mint:O14936|rcsb pdb:1KGD|rcsb pdb:1KWA|rcsb pdb:1ZL8|rcsb pdb:3C0G|rcsb pdb:3C0H|rcsb pdb:3C0I|rcsb pdb:3MFR|rcsb pdb:3MFS psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/10/11 rogid:j5ho+aD4tkX7bXXlROdiprUX1Mc9606 rogid:zTaBgQexJON3EVgJq9FHjf+aSCY9606 intact-crc:9F72FD50BF55E39F|rigid:bV4m56+z4dSFYYaXgpVyRQsWti0 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96RL1 uniprotkb:P47756 intact:EBI-725300|intact:EBI-1263554|uniprotkb:Q5XKQ1|uniprotkb:Q7Z3W7|uniprotkb:Q8N5B9|uniprotkb:Q9BZR1|uniprotkb:Q9BZR5|uniprotkb:Q9UHX7|uniprotkb:A8MSA1|uniprotkb:B3KMZ1|uniprotkb:B4E3N2|ensembl:ENSP00000366434|ensembl:ENSP00000421926 intact:EBI-353595|uniprotkb:Q5U0L4|uniprotkb:Q8TB49|uniprotkb:Q9NUC4|uniprotkb:Q32Q68|ensembl:ENSP00000364284|ensembl:ENSP00000501528 psi-mi:uimc1_human(display_long)|uniprotkb:Retinoid X receptor-interacting protein 110(gene name synonym)|uniprotkb:Receptor-associated protein 80(gene name synonym)|uniprotkb:Ubiquitin interaction motif-containing protein 1(gene name synonym)|uniprotkb:UIMC1(gene name)|psi-mi:UIMC1(display_short)|uniprotkb:RAP80(gene name synonym)|uniprotkb:RXRIP110(gene name synonym) psi-mi:capzb_human(display_long)|uniprotkb:CAPZB(gene name)|psi-mi:CAPZB(display_short)|uniprotkb:CapZ beta(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515432|imex:IM-12079-48 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001186226.1|refseq:NP_001186227.1|refseq:NP_057374.3|refseq:NP_001304890.1|ensembl:ENSG00000087206(gene)|ensembl:ENST00000377227(transcript)|ensembl:ENST00000511320(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006302"(double-strand break repair)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016604"(nuclear body)|go:"GO:0042393"(histone binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0070531"(BRCA1-A complex)|go:"GO:0070537"(histone H2A K63-linked deubiquitination)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR006642(Zinc finger, Rad18-type putative)|interpro:IPR038868|interpro:IPR040714|mint:Q96RL1|rcsb pdb:2MKF|rcsb pdb:2MKG|rcsb pdb:2N9E|rcsb pdb:2RR9|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473|refseq:XP_005265987.1|refseq:XP_005265993.1|refseq:XP_006714934.1|refseq:XP_016865063.1|refseq:XP_016865067.1|refseq:XP_016865068.1|dip:DIP-29936N refseq:NP_001193469.1|refseq:NP_004921.1|go:"GO:0045296"(cadherin binding)|go:"GO:0051015"(actin filament binding)|go:"GO:0051016"(barbed-end actin filament capping)|go:"GO:0051490"(negative regulation of filopodium assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071203"(WASH complex)|go:"GO:0097224"(sperm connecting piece)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|interpro:IPR001698(F-actin capping protein, beta subunit)|interpro:IPR019771|interpro:IPR037282|interpro:IPR042276|interpro:IPR043175|mint:P47756|reactome:R-HSA-2132295|reactome:R-HSA-3371497|reactome:R-HSA-6807878|reactome:R-HSA-6811436|reactome:R-HSA-9013405|reactome:R-HSA-9035034|reactome:R-HSA-9662360|reactome:R-HSA-983231|ensembl:ENSG00000077549(gene)|ensembl:ENST00000375142(transcript)|ensembl:ENST00000674432(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005903"(brush border)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0008290"(F-actin capping protein complex)|go:"GO:0010591"(regulation of lamellipodium assembly)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0022604"(regulation of cell morphogenesis)|go:"GO:0030017"(sarcomere)|go:"GO:0030027"(lamellipodium)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030863"(cortical cytoskeleton)|refseq:NP_001269091.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/10/11 rogid:j5ho+aD4tkX7bXXlROdiprUX1Mc9606 rogid:qRXsrB2fLT1DMVIVRWKFYe4Aln49606 intact-crc:9F72FD50BF55E39F|rigid:bV4m56+z4dSFYYaXgpVyRQsWti0 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96RL1 uniprotkb:Q99728 intact:EBI-725300|intact:EBI-1263554|uniprotkb:Q5XKQ1|uniprotkb:Q7Z3W7|uniprotkb:Q8N5B9|uniprotkb:Q9BZR1|uniprotkb:Q9BZR5|uniprotkb:Q9UHX7|uniprotkb:A8MSA1|uniprotkb:B3KMZ1|uniprotkb:B4E3N2|ensembl:ENSP00000366434|ensembl:ENSP00000421926 intact:EBI-473181|ensembl:ENSP00000260947|uniprotkb:O43574|uniprotkb:Q53SS5|uniprotkb:F6MDH7|uniprotkb:F6MDH8|uniprotkb:F6MDH9 psi-mi:uimc1_human(display_long)|uniprotkb:Retinoid X receptor-interacting protein 110(gene name synonym)|uniprotkb:Receptor-associated protein 80(gene name synonym)|uniprotkb:Ubiquitin interaction motif-containing protein 1(gene name synonym)|uniprotkb:UIMC1(gene name)|psi-mi:UIMC1(display_short)|uniprotkb:RAP80(gene name synonym)|uniprotkb:RXRIP110(gene name synonym) psi-mi:bard1_human(display_long)|uniprotkb:BARD1(gene name)|psi-mi:BARD1(display_short)|uniprotkb:RING-type E3 ubiquitin transferase BARD1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515432|imex:IM-12079-48 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001186226.1|refseq:NP_001186227.1|refseq:NP_057374.3|refseq:NP_001304890.1|ensembl:ENSG00000087206(gene)|ensembl:ENST00000377227(transcript)|ensembl:ENST00000511320(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006302"(double-strand break repair)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016604"(nuclear body)|go:"GO:0042393"(histone binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0070531"(BRCA1-A complex)|go:"GO:0070537"(histone H2A K63-linked deubiquitination)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR006642(Zinc finger, Rad18-type putative)|interpro:IPR038868|interpro:IPR040714|mint:Q96RL1|rcsb pdb:2MKF|rcsb pdb:2MKG|rcsb pdb:2N9E|rcsb pdb:2RR9|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473|refseq:XP_005265987.1|refseq:XP_005265993.1|refseq:XP_006714934.1|refseq:XP_016865063.1|refseq:XP_016865067.1|refseq:XP_016865068.1|dip:DIP-29936N ensembl:ENSG00000138376(gene)|ensembl:ENST00000260947(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0001894"(tissue homeostasis)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016607"(nuclear speck)|go:"GO:0019900"(kinase binding)|go:"GO:0031436"(BRCA1-BARD1 complex)|go:"GO:0031441"(negative regulation of mRNA 3'-end processing)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|refseq:NP_001269472.1|go:"GO:0042325"(regulation of phosphorylation)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046826"(negative regulation of protein export from nucleus)|go:"GO:0046872"(metal ion binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070531"(BRCA1-A complex)|go:"GO:0085020"(protein K6-linked ubiquitination)|interpro:IPR001357(BRCT)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002110(Ankyrin)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR020683|interpro:IPR036420|interpro:IPR036770|interpro:IPR039503|mint:Q99728|rcsb pdb:1JM7|rcsb pdb:2NTE|rcsb pdb:2R1Z|rcsb pdb:3C5R|rcsb pdb:3FA2|rcsb pdb:6M14|rcsb pdb:7E8I|rcsb pdb:7JZV|rcsb pdb:7LYC|reactome:R-HSA-5685938|reactome:R-HSA-5685942|reactome:R-HSA-5689603|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693568|reactome:R-HSA-5693571|reactome:R-HSA-5693579|reactome:R-HSA-5693607|reactome:R-HSA-5693616|reactome:R-HSA-6804756|reactome:R-HSA-69473|reactome:R-HSA-9663199|reactome:R-HSA-9699150|reactome:R-HSA-5693554|refseq:NP_000456.2|dip:DIP-5972N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/10/11 rogid:j5ho+aD4tkX7bXXlROdiprUX1Mc9606 rogid:5dT1T3GUceuvwPpiTv5QW/QEDgE9606 intact-crc:9F72FD50BF55E39F|rigid:bV4m56+z4dSFYYaXgpVyRQsWti0 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96RL1 uniprotkb:Q15018 intact:EBI-725300|intact:EBI-1263554|uniprotkb:Q5XKQ1|uniprotkb:Q7Z3W7|uniprotkb:Q8N5B9|uniprotkb:Q9BZR1|uniprotkb:Q9BZR5|uniprotkb:Q9UHX7|uniprotkb:A8MSA1|uniprotkb:B3KMZ1|uniprotkb:B4E3N2|ensembl:ENSP00000366434|ensembl:ENSP00000421926 intact:EBI-1056583|uniprotkb:Q96H11|uniprotkb:B4DKR2|intact:EBI-28981592|ensembl:ENSP00000298492 psi-mi:uimc1_human(display_long)|uniprotkb:Retinoid X receptor-interacting protein 110(gene name synonym)|uniprotkb:Receptor-associated protein 80(gene name synonym)|uniprotkb:Ubiquitin interaction motif-containing protein 1(gene name synonym)|uniprotkb:UIMC1(gene name)|psi-mi:UIMC1(display_short)|uniprotkb:RAP80(gene name synonym)|uniprotkb:RXRIP110(gene name synonym) psi-mi:abrx2_human(display_long)|uniprotkb:ABRAXAS2(gene name)|psi-mi:ABRAXAS2(display_short)|uniprotkb:ABRO1(gene name synonym)|uniprotkb:Abraxas brother protein 1(gene name synonym)|uniprotkb:FAM175B(gene name synonym)|uniprotkb:KIAA0157(gene name synonym)|uniprotkb:Protein FAM175B(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515432|imex:IM-12079-48 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001186226.1|refseq:NP_001186227.1|refseq:NP_057374.3|refseq:NP_001304890.1|ensembl:ENSG00000087206(gene)|ensembl:ENST00000377227(transcript)|ensembl:ENST00000511320(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006302"(double-strand break repair)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016604"(nuclear body)|go:"GO:0042393"(histone binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0070531"(BRCA1-A complex)|go:"GO:0070537"(histone H2A K63-linked deubiquitination)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR006642(Zinc finger, Rad18-type putative)|interpro:IPR038868|interpro:IPR040714|mint:Q96RL1|rcsb pdb:2MKF|rcsb pdb:2MKG|rcsb pdb:2N9E|rcsb pdb:2RR9|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473|refseq:XP_005265987.1|refseq:XP_005265993.1|refseq:XP_006714934.1|refseq:XP_016865063.1|refseq:XP_016865067.1|refseq:XP_016865068.1|dip:DIP-29936N ensembl:ENSP00000298492|refseq:NP_115558.3|ensembl:ENSG00000165660(gene)|ensembl:ENST00000298492(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000922"(spindle pole)|go:"GO:0002931"(response to ischemia)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0007059"(chromosome segregation)|go:"GO:0008017"(microtubule binding)|go:"GO:0008608"(attachment of spindle microtubules to kinetochore)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0051301"(cell division)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0070552"(BRISC complex)|go:"GO:0090307"(mitotic spindle assembly)|interpro:IPR023238|interpro:IPR023240|interpro:IPR037518|mint:Q15018|rcsb pdb:6H3C|rcsb pdb:6R8F|reactome:R-HSA-5689901 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/10/11 rogid:j5ho+aD4tkX7bXXlROdiprUX1Mc9606 rogid:fYZdQpH09qcBBUV1IKV2wsRk4m89606 intact-crc:9F72FD50BF55E39F|rigid:bV4m56+z4dSFYYaXgpVyRQsWti0 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96RL1 uniprotkb:P61201 intact:EBI-725300|intact:EBI-1263554|uniprotkb:Q5XKQ1|uniprotkb:Q7Z3W7|uniprotkb:Q8N5B9|uniprotkb:Q9BZR1|uniprotkb:Q9BZR5|uniprotkb:Q9UHX7|uniprotkb:A8MSA1|uniprotkb:B3KMZ1|uniprotkb:B4E3N2|ensembl:ENSP00000366434|ensembl:ENSP00000421926 intact:EBI-1050386|uniprotkb:O88950|uniprotkb:Q15647|uniprotkb:Q6FGP4|uniprotkb:Q9BY54|uniprotkb:Q9R249|uniprotkb:Q9UNI2|uniprotkb:Q9UNQ5|ensembl:ENSP00000373553 psi-mi:uimc1_human(display_long)|uniprotkb:Retinoid X receptor-interacting protein 110(gene name synonym)|uniprotkb:Receptor-associated protein 80(gene name synonym)|uniprotkb:Ubiquitin interaction motif-containing protein 1(gene name synonym)|uniprotkb:UIMC1(gene name)|psi-mi:UIMC1(display_short)|uniprotkb:RAP80(gene name synonym)|uniprotkb:RXRIP110(gene name synonym) psi-mi:csn2_human(display_long)|uniprotkb:JAB1-containing signalosome subunit 2(gene name synonym)|uniprotkb:Thyroid receptor-interacting protein 15(gene name synonym)|uniprotkb:Alien homolog(gene name synonym)|uniprotkb:COPS2(gene name)|psi-mi:COPS2(display_short)|uniprotkb:CSN2(gene name synonym)|uniprotkb:TRIP15(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515432|imex:IM-12079-48 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001186226.1|refseq:NP_001186227.1|refseq:NP_057374.3|refseq:NP_001304890.1|ensembl:ENSG00000087206(gene)|ensembl:ENST00000377227(transcript)|ensembl:ENST00000511320(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006302"(double-strand break repair)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016604"(nuclear body)|go:"GO:0042393"(histone binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0070531"(BRCA1-A complex)|go:"GO:0070537"(histone H2A K63-linked deubiquitination)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR006642(Zinc finger, Rad18-type putative)|interpro:IPR038868|interpro:IPR040714|mint:Q96RL1|rcsb pdb:2MKF|rcsb pdb:2MKG|rcsb pdb:2N9E|rcsb pdb:2RR9|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473|refseq:XP_005265987.1|refseq:XP_005265993.1|refseq:XP_006714934.1|refseq:XP_016865063.1|refseq:XP_016865067.1|refseq:XP_016865068.1|dip:DIP-29936N refseq:NP_001137359.1|refseq:NP_004227.1|ensembl:ENSG00000166200(gene)|ensembl:ENST00000388901(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000338"(protein deneddylation)|go:"GO:0001833"(inner cell mass cell proliferation)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0030182"(neuron differentiation)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:1903507"(negative regulation of nucleic acid-templated transcription)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR036390|interpro:IPR037750|mint:P61201|rcsb pdb:4D10|rcsb pdb:4D18|rcsb pdb:4WSN|rcsb pdb:6A73|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|rcsb pdb:6R7N|reactome:R-HSA-5696394|reactome:R-HSA-6781823|reactome:R-HSA-8856825|reactome:R-HSA-8951664|reactome:R-HSA-9013422|dip:DIP-42076N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/10/11 rogid:j5ho+aD4tkX7bXXlROdiprUX1Mc9606 rogid:MrlEHktIBvvcQux7Z7kqYJYgbbs9606 intact-crc:9F72FD50BF55E39F|rigid:bV4m56+z4dSFYYaXgpVyRQsWti0 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96RL1 uniprotkb:Q9UL15 intact:EBI-725300|intact:EBI-1263554|uniprotkb:Q5XKQ1|uniprotkb:Q7Z3W7|uniprotkb:Q8N5B9|uniprotkb:Q9BZR1|uniprotkb:Q9BZR5|uniprotkb:Q9UHX7|uniprotkb:A8MSA1|uniprotkb:B3KMZ1|uniprotkb:B4E3N2|ensembl:ENSP00000366434|ensembl:ENSP00000421926 intact:EBI-356517|uniprotkb:O94950|uniprotkb:Q86W59|ensembl:ENSP00000299204|ensembl:ENSP00000391713 psi-mi:uimc1_human(display_long)|uniprotkb:Retinoid X receptor-interacting protein 110(gene name synonym)|uniprotkb:Receptor-associated protein 80(gene name synonym)|uniprotkb:Ubiquitin interaction motif-containing protein 1(gene name synonym)|uniprotkb:UIMC1(gene name)|psi-mi:UIMC1(display_short)|uniprotkb:RAP80(gene name synonym)|uniprotkb:RXRIP110(gene name synonym) psi-mi:bag5_human(display_long)|uniprotkb:BAG5(gene name)|psi-mi:BAG5(display_short)|uniprotkb:KIAA0873(gene name synonym)|uniprotkb:Bcl-2-associated athanogene 5(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515432|imex:IM-12079-48 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001186226.1|refseq:NP_001186227.1|refseq:NP_057374.3|refseq:NP_001304890.1|ensembl:ENSG00000087206(gene)|ensembl:ENST00000377227(transcript)|ensembl:ENST00000511320(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006302"(double-strand break repair)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016604"(nuclear body)|go:"GO:0042393"(histone binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0070531"(BRCA1-A complex)|go:"GO:0070537"(histone H2A K63-linked deubiquitination)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR006642(Zinc finger, Rad18-type putative)|interpro:IPR038868|interpro:IPR040714|mint:Q96RL1|rcsb pdb:2MKF|rcsb pdb:2MKG|rcsb pdb:2N9E|rcsb pdb:2RR9|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473|refseq:XP_005265987.1|refseq:XP_005265993.1|refseq:XP_006714934.1|refseq:XP_016865063.1|refseq:XP_016865067.1|refseq:XP_016865068.1|dip:DIP-29936N refseq:NP_001015048.1|refseq:NP_001015049.1|refseq:NP_004864.1|go:"GO:0051444"(negative regulation of ubiquitin-protein transferase activity)|go:"GO:0061084"(negative regulation of protein refolding)|go:"GO:0070997"(neuron death)|go:"GO:0090083"(regulation of inclusion body assembly)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|interpro:IPR003103(Apoptosis regulator Bcl-2 protein, BAG)|interpro:IPR036533|interpro:IPR039773|mint:Q9UL15|rcsb pdb:2D9D|rcsb pdb:3A8Y|reactome:R-HSA-3371453|go:"GO:0051438"(regulation of ubiquitin-protein transferase activity)|ensembl:ENSG00000166170(gene)|ensembl:ENST00000299204(transcript)|ensembl:ENST00000445922(transcript)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0007030"(Golgi organization)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0016234"(inclusion body)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|dip:DIP-53428N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/10/11 rogid:j5ho+aD4tkX7bXXlROdiprUX1Mc9606 rogid:I5E45kk4QcYF/BEa5qh7IBeBzF09606 intact-crc:9F72FD50BF55E39F|rigid:bV4m56+z4dSFYYaXgpVyRQsWti0 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96RL1 uniprotkb:P08709 intact:EBI-725300|intact:EBI-1263554|uniprotkb:Q5XKQ1|uniprotkb:Q7Z3W7|uniprotkb:Q8N5B9|uniprotkb:Q9BZR1|uniprotkb:Q9BZR5|uniprotkb:Q9UHX7|uniprotkb:A8MSA1|uniprotkb:B3KMZ1|uniprotkb:B4E3N2|ensembl:ENSP00000366434|ensembl:ENSP00000421926 intact:EBI-355972|ensembl:ENSP00000364731|uniprotkb:Q14339|uniprotkb:Q5JVF2|uniprotkb:B0YJC8|uniprotkb:Q5JVF1|uniprotkb:Q9UD52|uniprotkb:Q9UD53|uniprotkb:Q9UD54 psi-mi:uimc1_human(display_long)|uniprotkb:Retinoid X receptor-interacting protein 110(gene name synonym)|uniprotkb:Receptor-associated protein 80(gene name synonym)|uniprotkb:Ubiquitin interaction motif-containing protein 1(gene name synonym)|uniprotkb:UIMC1(gene name)|psi-mi:UIMC1(display_short)|uniprotkb:RAP80(gene name synonym)|uniprotkb:RXRIP110(gene name synonym) psi-mi:fa7_human(display_long)|uniprotkb:F7(gene name)|psi-mi:F7(display_short)|uniprotkb:Serum prothrombin conversion accelerator(gene name synonym)|uniprotkb:Proconvertin(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515432|imex:IM-12079-48 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001186226.1|refseq:NP_001186227.1|refseq:NP_057374.3|refseq:NP_001304890.1|ensembl:ENSG00000087206(gene)|ensembl:ENST00000377227(transcript)|ensembl:ENST00000511320(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006302"(double-strand break repair)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016604"(nuclear body)|go:"GO:0042393"(histone binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0070531"(BRCA1-A complex)|go:"GO:0070537"(histone H2A K63-linked deubiquitination)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR006642(Zinc finger, Rad18-type putative)|interpro:IPR038868|interpro:IPR040714|mint:Q96RL1|rcsb pdb:2MKF|rcsb pdb:2MKG|rcsb pdb:2N9E|rcsb pdb:2RR9|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473|refseq:XP_005265987.1|refseq:XP_005265993.1|refseq:XP_006714934.1|refseq:XP_016865063.1|refseq:XP_016865067.1|refseq:XP_016865068.1|dip:DIP-29936N ensembl:ENSG00000057593(gene)|ensembl:ENST00000375581(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002690"(positive regulation of leukocyte chemotaxis)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0007596"(blood coagulation)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0010037"(response to carbon dioxide)|go:"GO:0010641"(positive regulation of platelet-derived growth factor receptor signaling pathway)|go:"GO:0016485"(protein processing)|go:"GO:0030194"(positive regulation of blood coagulation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031982"(vesicle)|go:"GO:0032355"(response to estradiol)|go:"GO:0032571"(response to vitamin K)|go:"GO:0033595"(response to genistein)|go:"GO:0043627"(response to estrogen)|rcsb pdb:1F7M|rcsb pdb:1FAK|rcsb pdb:1FF7|go:"GO:0050927"(positive regulation of positive chemotaxis)|rcsb pdb:1FFM|rcsb pdb:1J9C|rcsb pdb:1JBU|go:"GO:0051897"(positive regulation of protein kinase B signaling)|rcsb pdb:1KLI|go:"GO:0060416"(response to growth hormone)|go:"GO:0061476"(response to anticoagulant)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070723"(response to cholesterol)|go:"GO:0097068"(response to thyroxine)|go:"GO:1904400"(response to Thyroid stimulating hormone)|go:"GO:1904612"(response to 2,3,7,8-tetrachlorodibenzodioxine)|go:"GO:1905217"(response to astaxanthin)|go:"GO:1905225"(response to thyrotropin-releasing hormone)|go:"GO:1905286"(serine-type peptidase complex)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000294(Vitamin K-dependent carboxylation/gamma-carboxyglutamic region)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR012224(Peptidase S1A, coagulation factor VII/IX/X/C/Z)|interpro:IPR017857(Coagulation factor, subset, Gla region)|interpro:IPR018097|interpro:IPR018114|interpro:IPR033116|interpro:IPR033190|interpro:IPR035972|interpro:IPR043504|rcsb pdb:1BF9|rcsb pdb:1CVW|rcsb pdb:1DAN|rcsb pdb:1DVA|rcsb pdb:1F7E|rcsb pdb:1KLJ|rcsb pdb:1NL8|rcsb pdb:1O5D|rcsb pdb:1QFK|rcsb pdb:1W0Y|rcsb pdb:1W2K|rcsb pdb:1W7X|rcsb pdb:1W8B|rcsb pdb:1WQV|rcsb pdb:1WSS|rcsb pdb:1WTG|rcsb pdb:1WUN|rcsb pdb:1WV7|rcsb pdb:1YGC|rcsb pdb:1Z6J|rcsb pdb:2A2Q|rcsb pdb:2AEI|rcsb pdb:2AER|rcsb pdb:2B7D|rcsb pdb:2B8O|rcsb pdb:2BZ6|rcsb pdb:2C4F|rcsb pdb:2EC9|rcsb pdb:2F9B|rcsb pdb:2FIR|rcsb pdb:2FLB|rcsb pdb:2FLR|rcsb pdb:2PUQ|refseq:NP_000122.1|refseq:NP_062562.1|rcsb pdb:2ZP0|rcsb pdb:2ZWL|rcsb pdb:2ZZU|rcsb pdb:3ELA|rcsb pdb:3TH2|rcsb pdb:3TH3|rcsb pdb:3TH4|rcsb pdb:4IBL|rcsb pdb:4ISH|rcsb pdb:4ISI|rcsb pdb:4JYU|rcsb pdb:4JYV|rcsb pdb:4JZD|rcsb pdb:4JZE|rcsb pdb:4JZF|rcsb pdb:4NA9|rcsb pdb:4NG9|rcsb pdb:4NGA|rcsb pdb:4X8S|rcsb pdb:4X8T|rcsb pdb:4X8U|rcsb pdb:4X8V|rcsb pdb:4YLQ|rcsb pdb:4YT6|rcsb pdb:4YT7|rcsb pdb:4Z6A|rcsb pdb:4ZMA|rcsb pdb:4ZXX|rcsb pdb:4ZXY|rcsb pdb:5I46|rcsb pdb:5L0S|rcsb pdb:5L2Y|rcsb pdb:5L2Z|rcsb pdb:5L30|rcsb pdb:5PA8|rcsb pdb:5PA9|rcsb pdb:5PAA|rcsb pdb:5PAB|rcsb pdb:5PAC|rcsb pdb:5PAE|rcsb pdb:5PAF|rcsb pdb:5PAG|rcsb pdb:5PAI|rcsb pdb:5PAJ|rcsb pdb:5PAK|rcsb pdb:5PAM|rcsb pdb:5PAN|rcsb pdb:5PAO|rcsb pdb:5PAQ|rcsb pdb:5PAR|rcsb pdb:5PAS|rcsb pdb:5PAT|rcsb pdb:5PAU|rcsb pdb:5PAV|rcsb pdb:5PAW|rcsb pdb:5PAX|rcsb pdb:5PAY|rcsb pdb:5PB0|rcsb pdb:5PB1|rcsb pdb:5PB2|rcsb pdb:5PB3|rcsb pdb:5PB4|rcsb pdb:5PB5|rcsb pdb:5PB6|rcsb pdb:5TQE|rcsb pdb:5TQF|rcsb pdb:5TQG|rcsb pdb:5U6J|reactome:R-HSA-1368108|reactome:R-HSA-140834|reactome:R-HSA-159740|reactome:R-HSA-159763|reactome:R-HSA-159782|dip:DIP-6135N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/10/11 rogid:j5ho+aD4tkX7bXXlROdiprUX1Mc9606 rogid:3AajTD0zonhwhwLyNtQ1rIKrgRI9606 intact-crc:9F72FD50BF55E39F|rigid:bV4m56+z4dSFYYaXgpVyRQsWti0 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96RL1 uniprotkb:Q8TAF3 intact:EBI-725300|intact:EBI-1263554|uniprotkb:Q5XKQ1|uniprotkb:Q7Z3W7|uniprotkb:Q8N5B9|uniprotkb:Q9BZR1|uniprotkb:Q9BZR5|uniprotkb:Q9UHX7|uniprotkb:A8MSA1|uniprotkb:B3KMZ1|uniprotkb:B4E3N2|ensembl:ENSP00000366434|ensembl:ENSP00000421926 intact:EBI-1045469|uniprotkb:Q63HJ2|uniprotkb:Q658Y1|uniprotkb:Q8N3Z1|uniprotkb:Q9NSK8|uniprotkb:Q9P279|uniprotkb:B4DM86|uniprotkb:B4DQI2|uniprotkb:B4DY84|ensembl:ENSP00000307491 psi-mi:uimc1_human(display_long)|uniprotkb:Retinoid X receptor-interacting protein 110(gene name synonym)|uniprotkb:Receptor-associated protein 80(gene name synonym)|uniprotkb:Ubiquitin interaction motif-containing protein 1(gene name synonym)|uniprotkb:UIMC1(gene name)|psi-mi:UIMC1(display_short)|uniprotkb:RAP80(gene name synonym)|uniprotkb:RXRIP110(gene name synonym) psi-mi:wdr48_human(display_long)|uniprotkb:WD repeat endosomal protein(gene name synonym)|uniprotkb:p80(gene name synonym)|uniprotkb:WDR48(gene name)|psi-mi:WDR48(display_short)|uniprotkb:KIAA1449(gene name synonym)|uniprotkb:UAF1(gene name synonym)|uniprotkb:USP1-associated factor 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515432|imex:IM-12079-48 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001186226.1|refseq:NP_001186227.1|refseq:NP_057374.3|refseq:NP_001304890.1|ensembl:ENSG00000087206(gene)|ensembl:ENST00000377227(transcript)|ensembl:ENST00000511320(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006302"(double-strand break repair)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016604"(nuclear body)|go:"GO:0042393"(histone binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0070531"(BRCA1-A complex)|go:"GO:0070537"(histone H2A K63-linked deubiquitination)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR006642(Zinc finger, Rad18-type putative)|interpro:IPR038868|interpro:IPR040714|mint:Q96RL1|rcsb pdb:2MKF|rcsb pdb:2MKG|rcsb pdb:2N9E|rcsb pdb:2RR9|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473|refseq:XP_005265987.1|refseq:XP_005265993.1|refseq:XP_006714934.1|refseq:XP_016865063.1|refseq:XP_016865067.1|refseq:XP_016865068.1|dip:DIP-29936N refseq:NP_065890.1|ensembl:ENSG00000114742(gene)|ensembl:ENST00000302313(transcript)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0003677"(DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043588"(skin development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0072520"(seminiferous tubule development)|go:"GO:1902525"(regulation of protein monoubiquitination)|go:"GO:1903003"(positive regulation of protein deubiquitination)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR021772|interpro:IPR036322|mint:Q8TAF3|rcsb pdb:5CVL|rcsb pdb:5CVN|rcsb pdb:5CVO|rcsb pdb:5K1A|rcsb pdb:5K1B|rcsb pdb:5K1C|rcsb pdb:5L8E|rcsb pdb:5L8W|rcsb pdb:6JLQ|rcsb pdb:7AY0|rcsb pdb:7AY1|rcsb pdb:7AY2|reactome:R-HSA-110314|reactome:R-HSA-5689880|reactome:R-HSA-6783310|reactome:R-HSA-9673766|refseq:NP_001290331.1|refseq:NP_001290332.1|refseq:NP_001333156.1|refseq:NP_001333157.1|dip:DIP-50841N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/10/11 rogid:j5ho+aD4tkX7bXXlROdiprUX1Mc9606 rogid:S8ihl3jxEEyMS46AM2ynXSFfCU49606 intact-crc:9F72FD50BF55E39F|rigid:bV4m56+z4dSFYYaXgpVyRQsWti0 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96RL1 uniprotkb:Q13564 intact:EBI-725300|intact:EBI-1263554|uniprotkb:Q5XKQ1|uniprotkb:Q7Z3W7|uniprotkb:Q8N5B9|uniprotkb:Q9BZR1|uniprotkb:Q9BZR5|uniprotkb:Q9UHX7|uniprotkb:A8MSA1|uniprotkb:B3KMZ1|uniprotkb:B4E3N2|ensembl:ENSP00000366434|ensembl:ENSP00000421926 intact:EBI-718631|uniprotkb:A6NFN4|uniprotkb:B2R700|uniprotkb:A6NCK0|uniprotkb:A8MU28|uniprotkb:B3KUP9|ensembl:ENSP00000290810 psi-mi:uimc1_human(display_long)|uniprotkb:Retinoid X receptor-interacting protein 110(gene name synonym)|uniprotkb:Receptor-associated protein 80(gene name synonym)|uniprotkb:Ubiquitin interaction motif-containing protein 1(gene name synonym)|uniprotkb:UIMC1(gene name)|psi-mi:UIMC1(display_short)|uniprotkb:RAP80(gene name synonym)|uniprotkb:RXRIP110(gene name synonym) psi-mi:ula1_human(display_long)|uniprotkb:APPBP1(gene name synonym)|uniprotkb:Amyloid protein-binding protein 1(gene name synonym)|uniprotkb:Amyloid beta precursor protein-binding protein 1, 59 kDa(gene name synonym)|uniprotkb:Proto-oncogene protein 1(gene name synonym)|uniprotkb:NAE1(gene name)|psi-mi:NAE1(display_short)|uniprotkb:HPP1(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515432|imex:IM-12079-48 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001186226.1|refseq:NP_001186227.1|refseq:NP_057374.3|refseq:NP_001304890.1|ensembl:ENSG00000087206(gene)|ensembl:ENST00000377227(transcript)|ensembl:ENST00000511320(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006302"(double-strand break repair)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016604"(nuclear body)|go:"GO:0042393"(histone binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0070531"(BRCA1-A complex)|go:"GO:0070537"(histone H2A K63-linked deubiquitination)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR006642(Zinc finger, Rad18-type putative)|interpro:IPR038868|interpro:IPR040714|mint:Q96RL1|rcsb pdb:2MKF|rcsb pdb:2MKG|rcsb pdb:2N9E|rcsb pdb:2RR9|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473|refseq:XP_005265987.1|refseq:XP_005265993.1|refseq:XP_006714934.1|refseq:XP_016865063.1|refseq:XP_016865067.1|refseq:XP_016865068.1|dip:DIP-29936N refseq:NP_001273429.1|refseq:NP_001018169.1|refseq:NP_001018170.1|refseq:NP_003896.1|refseq:XP_011521724.1|refseq:XP_005256272.1|ensembl:ENSG00000159593(gene)|ensembl:ENST00000290810(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0019781"(NEDD8 activating enzyme activity)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033314"(mitotic DNA replication checkpoint signaling)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0045116"(protein neddylation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051402"(neuron apoptotic process)|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR030667|interpro:IPR035985|mint:Q13564|rcsb pdb:1R4M|rcsb pdb:1R4N|rcsb pdb:1TT5|rcsb pdb:1YOV|rcsb pdb:2NVU|rcsb pdb:3DBH|rcsb pdb:3DBL|rcsb pdb:3DBR|rcsb pdb:3GZN|reactome:R-HSA-8951664 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/10/11 rogid:j5ho+aD4tkX7bXXlROdiprUX1Mc9606 rogid:IPyDtfN10ZJIeQatu2Z/SwskHXk9606 intact-crc:9F72FD50BF55E39F|rigid:bV4m56+z4dSFYYaXgpVyRQsWti0 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96RL1 uniprotkb:P46736 intact:EBI-725300|intact:EBI-1263554|uniprotkb:Q5XKQ1|uniprotkb:Q7Z3W7|uniprotkb:Q8N5B9|uniprotkb:Q9BZR1|uniprotkb:Q9BZR5|uniprotkb:Q9UHX7|uniprotkb:A8MSA1|uniprotkb:B3KMZ1|uniprotkb:B4E3N2|ensembl:ENSP00000366434|ensembl:ENSP00000421926 intact:EBI-750352|uniprotkb:Q16107|uniprotkb:Q9BTZ6|uniprotkb:A6QRF8|uniprotkb:A6QRF9|uniprotkb:A8MUX5|uniprotkb:A8MWH0|uniprotkb:A9Z1Y0|uniprotkb:A9Z1Y5|uniprotkb:B1B062|uniprotkb:B4DQN7|uniprotkb:Q53YX5|ensembl:ENSP00000358474 psi-mi:uimc1_human(display_long)|uniprotkb:Retinoid X receptor-interacting protein 110(gene name synonym)|uniprotkb:Receptor-associated protein 80(gene name synonym)|uniprotkb:Ubiquitin interaction motif-containing protein 1(gene name synonym)|uniprotkb:UIMC1(gene name)|psi-mi:UIMC1(display_short)|uniprotkb:RAP80(gene name synonym)|uniprotkb:RXRIP110(gene name synonym) psi-mi:brcc3_human(display_long)|uniprotkb:BRCC3(gene name)|psi-mi:BRCC3(display_short)|uniprotkb:C6.1A(gene name synonym)|uniprotkb:CXorf53(gene name synonym)|uniprotkb:BRCC36(gene name synonym)|uniprotkb:BRCA1-A complex subunit BRCC36(gene name synonym)|uniprotkb:BRISC complex subunit BRCC36(gene name synonym)|uniprotkb:BRCA1/BRCA2-containing complex subunit 3(gene name synonym)|uniprotkb:BRCA1/BRCA2-containing complex subunit 36(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515432|imex:IM-12079-48 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001186226.1|refseq:NP_001186227.1|refseq:NP_057374.3|refseq:NP_001304890.1|ensembl:ENSG00000087206(gene)|ensembl:ENST00000377227(transcript)|ensembl:ENST00000511320(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006302"(double-strand break repair)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016604"(nuclear body)|go:"GO:0042393"(histone binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0070531"(BRCA1-A complex)|go:"GO:0070537"(histone H2A K63-linked deubiquitination)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR006642(Zinc finger, Rad18-type putative)|interpro:IPR038868|interpro:IPR040714|mint:Q96RL1|rcsb pdb:2MKF|rcsb pdb:2MKG|rcsb pdb:2N9E|rcsb pdb:2RR9|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473|refseq:XP_005265987.1|refseq:XP_005265993.1|refseq:XP_006714934.1|refseq:XP_016865063.1|refseq:XP_016865067.1|refseq:XP_016865068.1|dip:DIP-29936N refseq:NP_001018065.1|refseq:NP_001229569.1|refseq:NP_077308.1|refseq:XP_016885327.1|dip:DIP-48719N|ensembl:ENSG00000185515(gene)|go:"GO:0000152"(nuclear ubiquitin ligase complex)|go:"GO:0000922"(spindle pole)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0010165"(response to X-ray)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0046872"(metal ion binding)|go:"GO:0051301"(cell division)|go:"GO:0061578"(Lys63-specific deubiquitinase activity)|go:"GO:0070122"(isopeptidase activity)|ensembl:ENST00000369462(transcript)|go:"GO:0070531"(BRCA1-A complex)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0070537"(histone H2A K63-linked deubiquitination)|go:"GO:0070552"(BRISC complex)|go:"GO:0000151"(ubiquitin ligase complex)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR033860|interpro:IPR037518|interpro:IPR040749|mint:P46736|rcsb pdb:6H3C|rcsb pdb:6R8F|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473 psi-mi:"MI:0469"(intact) - caution:This sequence has been withdrawn from Uniprot.|crc64:5720358C1A2F7421 figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/10/11 rogid:j5ho+aD4tkX7bXXlROdiprUX1Mc9606 rogid:4YP0TYSnZOZQ4mFEmr07XIx+AVw9606 intact-crc:9F72FD50BF55E39F|rigid:bV4m56+z4dSFYYaXgpVyRQsWti0 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96RL1 uniprotkb:Q9NXR7 intact:EBI-725300|intact:EBI-1263554|uniprotkb:Q5XKQ1|uniprotkb:Q7Z3W7|uniprotkb:Q8N5B9|uniprotkb:Q9BZR1|uniprotkb:Q9BZR5|uniprotkb:Q9UHX7|uniprotkb:A8MSA1|uniprotkb:B3KMZ1|uniprotkb:B4E3N2|ensembl:ENSP00000366434|ensembl:ENSP00000421926 intact:EBI-949389|ensembl:ENSP00000339371|ensembl:ENSP00000368945|uniprotkb:Q13880|uniprotkb:Q96P06|uniprotkb:A8K4X1|uniprotkb:Q4ZFX8|uniprotkb:Q53SD0|uniprotkb:Q969X9|uniprotkb:D6W562|uniprotkb:D6W563 psi-mi:uimc1_human(display_long)|uniprotkb:Retinoid X receptor-interacting protein 110(gene name synonym)|uniprotkb:Receptor-associated protein 80(gene name synonym)|uniprotkb:Ubiquitin interaction motif-containing protein 1(gene name synonym)|uniprotkb:UIMC1(gene name)|psi-mi:UIMC1(display_short)|uniprotkb:RAP80(gene name synonym)|uniprotkb:RXRIP110(gene name synonym) psi-mi:baba2_human(display_long)|uniprotkb:BABAM2(gene name)|psi-mi:BABAM2(display_short)|uniprotkb:BRCA1-A complex subunit BRE(gene name synonym)|uniprotkb:BRCA1/BRCA2-containing complex subunit 45(gene name synonym)|uniprotkb:BRCC45(gene name synonym)|uniprotkb:BRE(gene name synonym)|uniprotkb:Brain and reproductive organ-expressed protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515432|imex:IM-12079-48 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001186226.1|refseq:NP_001186227.1|refseq:NP_057374.3|refseq:NP_001304890.1|ensembl:ENSG00000087206(gene)|ensembl:ENST00000377227(transcript)|ensembl:ENST00000511320(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006302"(double-strand break repair)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016604"(nuclear body)|go:"GO:0042393"(histone binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0070531"(BRCA1-A complex)|go:"GO:0070537"(histone H2A K63-linked deubiquitination)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR006642(Zinc finger, Rad18-type putative)|interpro:IPR038868|interpro:IPR040714|mint:Q96RL1|rcsb pdb:2MKF|rcsb pdb:2MKG|rcsb pdb:2N9E|rcsb pdb:2RR9|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473|refseq:XP_005265987.1|refseq:XP_005265993.1|refseq:XP_006714934.1|refseq:XP_016865063.1|refseq:XP_016865067.1|refseq:XP_016865068.1|dip:DIP-29936N ensembl:ENSG00000158019(gene)|ensembl:ENST00000342045(transcript)|ensembl:ENST00000379624(transcript)|go:"GO:0000152"(nuclear ubiquitin ligase complex)|go:"GO:0000268"(peroxisome targeting sequence binding)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0007165"(signal transduction)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0051301"(cell division)|go:"GO:0070531"(BRCA1-A complex)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0070552"(BRISC complex)|interpro:IPR010358(Brain and reproductive organ-expressed)|rcsb pdb:6H3C|rcsb pdb:6R8F|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473|go:"GO:0006302"(double-strand break repair)|refseq:NP_004890.2|refseq:NP_954661.1|refseq:NP_954662.1|refseq:NP_954663.1|refseq:NP_954664.1|refseq:NP_001248769.1|refseq:NP_001316041.1|refseq:NP_001316042.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/10/11 rogid:j5ho+aD4tkX7bXXlROdiprUX1Mc9606 rogid:ULbrw0O7e5M0Hzho3d05OlUnEGM9606 intact-crc:9F72FD50BF55E39F|rigid:bV4m56+z4dSFYYaXgpVyRQsWti0 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96RL1 uniprotkb:P06493 intact:EBI-725300|intact:EBI-1263554|uniprotkb:Q5XKQ1|uniprotkb:Q7Z3W7|uniprotkb:Q8N5B9|uniprotkb:Q9BZR1|uniprotkb:Q9BZR5|uniprotkb:Q9UHX7|uniprotkb:A8MSA1|uniprotkb:B3KMZ1|uniprotkb:B4E3N2|ensembl:ENSP00000366434|ensembl:ENSP00000421926 intact:EBI-444308|ensembl:ENSP00000378699|uniprotkb:O60764|uniprotkb:C9J497|uniprotkb:A8K7C4 psi-mi:uimc1_human(display_long)|uniprotkb:Retinoid X receptor-interacting protein 110(gene name synonym)|uniprotkb:Receptor-associated protein 80(gene name synonym)|uniprotkb:Ubiquitin interaction motif-containing protein 1(gene name synonym)|uniprotkb:UIMC1(gene name)|psi-mi:UIMC1(display_short)|uniprotkb:RAP80(gene name synonym)|uniprotkb:RXRIP110(gene name synonym) psi-mi:cdk1_human(display_long)|uniprotkb:p34 protein kinase(gene name synonym)|uniprotkb:Cell division protein kinase 1(gene name synonym)|uniprotkb:CDK1(gene name)|psi-mi:CDK1(display_short)|uniprotkb:CDC2(gene name synonym)|uniprotkb:Cell division control protein 2 homolog(gene name synonym)|uniprotkb:CDC28A(gene name synonym)|uniprotkb:CDKN1(gene name synonym)|uniprotkb:P34CDC2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515432|imex:IM-12079-48 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001186226.1|refseq:NP_001186227.1|refseq:NP_057374.3|refseq:NP_001304890.1|ensembl:ENSG00000087206(gene)|ensembl:ENST00000377227(transcript)|ensembl:ENST00000511320(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006302"(double-strand break repair)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016604"(nuclear body)|go:"GO:0042393"(histone binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0070531"(BRCA1-A complex)|go:"GO:0070537"(histone H2A K63-linked deubiquitination)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR006642(Zinc finger, Rad18-type putative)|interpro:IPR038868|interpro:IPR040714|mint:Q96RL1|rcsb pdb:2MKF|rcsb pdb:2MKG|rcsb pdb:2N9E|rcsb pdb:2RR9|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473|refseq:XP_005265987.1|refseq:XP_005265993.1|refseq:XP_006714934.1|refseq:XP_016865063.1|refseq:XP_016865067.1|refseq:XP_016865068.1|dip:DIP-29936N go:"GO:0006281"(DNA repair)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007344"(pronuclear fusion)|go:"GO:0007569"(cell aging)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0014038"(regulation of Schwann cell differentiation)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014075"(response to amine)|go:"GO:0014823"(response to activity)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030261"(chromosome condensation)|go:"GO:0030332"(cyclin binding)|go:"GO:0030496"(midbody)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0034501"(protein localization to kinetochore)|go:"GO:0035173"(histone kinase activity)|go:"GO:0006260"(DNA replication)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0046688"(response to copper ion)|go:"GO:0048511"(rhythmic process)|go:"GO:0048678"(response to axon injury)|go:"GO:0051301"(cell division)|go:"GO:0055015"(ventricular cardiac muscle cell development)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0042493"|go:"GO:0072686"(mitotic spindle)|go:"GO:0090166"(Golgi disassembly)|go:"GO:0097125"(cyclin B1-CDK1 complex)|go:"GO:0097472"(cyclin-dependent protein kinase activity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1905448"(positive regulation of mitochondrial ATP synthesis coupled electron transport)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P06493|rcsb pdb:1LC9|rcsb pdb:4Y72|rcsb pdb:4YC3|rcsb pdb:4YC6|rcsb pdb:5HQ0|rcsb pdb:5LQF|rcsb pdb:6GU2|rcsb pdb:6GU3|rcsb pdb:6GU4|rcsb pdb:6GU6|go:"GO:0042752"(regulation of circadian rhythm)|rcsb pdb:6GU7|rcsb pdb:6TWN|reactome:R-HSA-110056|reactome:R-HSA-113507|reactome:R-HSA-1362300|reactome:R-HSA-162658|reactome:R-HSA-170145|reactome:R-HSA-174048|reactome:R-HSA-174184|reactome:R-HSA-176408|reactome:R-HSA-176412|reactome:R-HSA-176417|reactome:R-HSA-2299718|reactome:R-HSA-2465910|reactome:R-HSA-2500257|reactome:R-HSA-2514853|reactome:R-HSA-2565942|reactome:R-HSA-2980767|reactome:R-HSA-2995383|reactome:R-HSA-3301854|reactome:R-HSA-380259|reactome:R-HSA-380270|reactome:R-HSA-380284|reactome:R-HSA-380320|reactome:R-HSA-4419969|reactome:R-HSA-5620912|reactome:R-HSA-5687128|reactome:R-HSA-5689896|reactome:R-HSA-6804114|reactome:R-HSA-6804757|reactome:R-HSA-68875|reactome:R-HSA-69205|reactome:R-HSA-69273|reactome:R-HSA-69478|reactome:R-HSA-75035|reactome:R-HSA-8852276|reactome:R-HSA-8854518|reactome:R-HSA-8878166|ensembl:ENSG00000170312(gene)|ensembl:ENST00000395284(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001618"(virus receptor activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005876"(spindle microtubule)|refseq:NP_001777.1|refseq:NP_203698.1|refseq:XP_005270360.1|refseq:NP_001307847.1|dip:DIP-35N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/10/11 rogid:j5ho+aD4tkX7bXXlROdiprUX1Mc9606 rogid:8geyXVp0Rpm8sG8I76/XgWsZ4JA9606 intact-crc:9F72FD50BF55E39F|rigid:bV4m56+z4dSFYYaXgpVyRQsWti0 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96RL1 uniprotkb:Q9NUP9 intact:EBI-725300|intact:EBI-1263554|uniprotkb:Q5XKQ1|uniprotkb:Q7Z3W7|uniprotkb:Q8N5B9|uniprotkb:Q9BZR1|uniprotkb:Q9BZR5|uniprotkb:Q9UHX7|uniprotkb:A8MSA1|uniprotkb:B3KMZ1|uniprotkb:B4E3N2|ensembl:ENSP00000366434|ensembl:ENSP00000421926 intact:EBI-1171517|ensembl:ENSP00000278193 psi-mi:uimc1_human(display_long)|uniprotkb:Retinoid X receptor-interacting protein 110(gene name synonym)|uniprotkb:Receptor-associated protein 80(gene name synonym)|uniprotkb:Ubiquitin interaction motif-containing protein 1(gene name synonym)|uniprotkb:UIMC1(gene name)|psi-mi:UIMC1(display_short)|uniprotkb:RAP80(gene name synonym)|uniprotkb:RXRIP110(gene name synonym) psi-mi:lin7c_human(display_long)|uniprotkb:Mammalian lin-seven protein 3(gene name synonym)|uniprotkb:Vertebrate lin-7 homolog 3(gene name synonym)|uniprotkb:LIN7C(gene name)|psi-mi:LIN7C(display_short)|uniprotkb:MALS3(gene name synonym)|uniprotkb:VELI3(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515432|imex:IM-12079-48 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001186226.1|refseq:NP_001186227.1|refseq:NP_057374.3|refseq:NP_001304890.1|ensembl:ENSG00000087206(gene)|ensembl:ENST00000377227(transcript)|ensembl:ENST00000511320(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006302"(double-strand break repair)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016604"(nuclear body)|go:"GO:0042393"(histone binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0070531"(BRCA1-A complex)|go:"GO:0070537"(histone H2A K63-linked deubiquitination)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR006642(Zinc finger, Rad18-type putative)|interpro:IPR038868|interpro:IPR040714|mint:Q96RL1|rcsb pdb:2MKF|rcsb pdb:2MKG|rcsb pdb:2N9E|rcsb pdb:2RR9|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473|refseq:XP_005265987.1|refseq:XP_005265993.1|refseq:XP_006714934.1|refseq:XP_016865063.1|refseq:XP_016865067.1|refseq:XP_016865068.1|dip:DIP-29936N refseq:NP_060832.1|ensembl:ENSG00000148943(gene)|ensembl:ENST00000278193(transcript)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006887"(exocytosis)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0015031"(protein transport)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0045199"(maintenance of epithelial cell apical/basal polarity)|go:"GO:0045202"(synapse)|go:"GO:0097016"(L27 domain binding)|go:"GO:0097025"(MPP7-DLG1-LIN7 complex)|go:"GO:0098793"(presynapse)|go:"GO:0098839"(postsynaptic density membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1903361"(protein localization to basolateral plasma membrane)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR004172(L27)|interpro:IPR014775(L27, C-terminal)|interpro:IPR017365(Lin-7 homologue)|interpro:IPR036034|interpro:IPR036892|mint:Q9NUP9|rcsb pdb:3LRA|reactome:R-HSA-212676|reactome:R-HSA-6794361|reactome:R-HSA-9609736 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/10/11 rogid:j5ho+aD4tkX7bXXlROdiprUX1Mc9606 rogid:F2rasaJ64Olc9qScN79LJRqsUEE9606 intact-crc:9F72FD50BF55E39F|rigid:bV4m56+z4dSFYYaXgpVyRQsWti0 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96RL1 uniprotkb:Q8IYQ7 intact:EBI-725300|intact:EBI-1263554|uniprotkb:Q5XKQ1|uniprotkb:Q7Z3W7|uniprotkb:Q8N5B9|uniprotkb:Q9BZR1|uniprotkb:Q9BZR5|uniprotkb:Q9UHX7|uniprotkb:A8MSA1|uniprotkb:B3KMZ1|uniprotkb:B4E3N2|ensembl:ENSP00000366434|ensembl:ENSP00000421926 intact:EBI-2515422|ensembl:ENSP00000365534|ensembl:ENSP00000434887|uniprotkb:Q5VV21|uniprotkb:B3KWL1|uniprotkb:D3DRV3 psi-mi:uimc1_human(display_long)|uniprotkb:Retinoid X receptor-interacting protein 110(gene name synonym)|uniprotkb:Receptor-associated protein 80(gene name synonym)|uniprotkb:Ubiquitin interaction motif-containing protein 1(gene name synonym)|uniprotkb:UIMC1(gene name)|psi-mi:UIMC1(display_short)|uniprotkb:RAP80(gene name synonym)|uniprotkb:RXRIP110(gene name synonym) psi-mi:thns1_human(display_long)|uniprotkb:THNSL1(gene name)|psi-mi:THNSL1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515432|imex:IM-12079-48 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001186226.1|refseq:NP_001186227.1|refseq:NP_057374.3|refseq:NP_001304890.1|ensembl:ENSG00000087206(gene)|ensembl:ENST00000377227(transcript)|ensembl:ENST00000511320(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006302"(double-strand break repair)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016604"(nuclear body)|go:"GO:0042393"(histone binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0070531"(BRCA1-A complex)|go:"GO:0070537"(histone H2A K63-linked deubiquitination)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR006642(Zinc finger, Rad18-type putative)|interpro:IPR038868|interpro:IPR040714|mint:Q96RL1|rcsb pdb:2MKF|rcsb pdb:2MKG|rcsb pdb:2N9E|rcsb pdb:2RR9|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473|refseq:XP_005265987.1|refseq:XP_005265993.1|refseq:XP_006714934.1|refseq:XP_016865063.1|refseq:XP_016865067.1|refseq:XP_016865068.1|dip:DIP-29936N ensembl:ENSG00000185875(gene)|ensembl:ENST00000376356(transcript)|ensembl:ENST00000524413(transcript)|interpro:IPR000623(Shikimate kinase)|interpro:IPR004450(Threonine synthase)|interpro:IPR027417|interpro:IPR029144|interpro:IPR031322|interpro:IPR036052|interpro:IPR037158|refseq:XP_016872154.1|refseq:NP_079114.3|refseq:XP_005252654.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/10/11 rogid:j5ho+aD4tkX7bXXlROdiprUX1Mc9606 rogid:kAjeYzxUImucaliHBZD7OMlQAjQ9606 intact-crc:9F72FD50BF55E39F|rigid:bV4m56+z4dSFYYaXgpVyRQsWti0 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96RL1 uniprotkb:Q9NWV8 intact:EBI-725300|intact:EBI-1263554|uniprotkb:Q5XKQ1|uniprotkb:Q7Z3W7|uniprotkb:Q8N5B9|uniprotkb:Q9BZR1|uniprotkb:Q9BZR5|uniprotkb:Q9UHX7|uniprotkb:A8MSA1|uniprotkb:B3KMZ1|uniprotkb:B4E3N2|ensembl:ENSP00000366434|ensembl:ENSP00000421926 intact:EBI-745725|uniprotkb:Q6FIA0|uniprotkb:Q9P018|uniprotkb:A8MQT0|uniprotkb:B4DRY9|uniprotkb:B4DVR1|ensembl:ENSP00000352408|ensembl:ENSP00000470920|ensembl:ENSP00000471605 psi-mi:uimc1_human(display_long)|uniprotkb:Retinoid X receptor-interacting protein 110(gene name synonym)|uniprotkb:Receptor-associated protein 80(gene name synonym)|uniprotkb:Ubiquitin interaction motif-containing protein 1(gene name synonym)|uniprotkb:UIMC1(gene name)|psi-mi:UIMC1(display_short)|uniprotkb:RAP80(gene name synonym)|uniprotkb:RXRIP110(gene name synonym) psi-mi:baba1_human(display_long)|uniprotkb:BABAM1(gene name)|psi-mi:BABAM1(display_short)|uniprotkb:HSPC142(orf name)|uniprotkb:C19orf62(gene name synonym)|uniprotkb:NBA1(gene name synonym)|uniprotkb:Mediator of RAP80 interactions and targeting subunit of 40 kDa(gene name synonym)|uniprotkb:New component of the BRCA1-A complex(gene name synonym)|uniprotkb:MERIT40(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515432|imex:IM-12079-48 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001186226.1|refseq:NP_001186227.1|refseq:NP_057374.3|refseq:NP_001304890.1|ensembl:ENSG00000087206(gene)|ensembl:ENST00000377227(transcript)|ensembl:ENST00000511320(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006302"(double-strand break repair)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016604"(nuclear body)|go:"GO:0042393"(histone binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0070531"(BRCA1-A complex)|go:"GO:0070537"(histone H2A K63-linked deubiquitination)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR006642(Zinc finger, Rad18-type putative)|interpro:IPR038868|interpro:IPR040714|mint:Q96RL1|rcsb pdb:2MKF|rcsb pdb:2MKG|rcsb pdb:2N9E|rcsb pdb:2RR9|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473|refseq:XP_005265987.1|refseq:XP_005265993.1|refseq:XP_006714934.1|refseq:XP_016865063.1|refseq:XP_016865067.1|refseq:XP_016865068.1|dip:DIP-29936N refseq:NP_001028721.1|refseq:NP_054892.2|ensembl:ENSG00000105393(gene)|ensembl:ENST00000359435(transcript)|ensembl:ENST00000598188(transcript)|ensembl:ENST00000601043(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006325"(chromatin organization)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016604"(nuclear body)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0051301"(cell division)|go:"GO:0070531"(BRCA1-A complex)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0070552"(BRISC complex)|interpro:IPR026126|interpro:IPR036465|mint:Q9NWV8|rcsb pdb:6H3C|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473|refseq:NP_001275685.1|refseq:NP_001275686.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/10/11 rogid:j5ho+aD4tkX7bXXlROdiprUX1Mc9606 rogid:o71OvjzuL/7w4247ap7fm6i3pXU9606 intact-crc:9F72FD50BF55E39F|rigid:bV4m56+z4dSFYYaXgpVyRQsWti0 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96RL1 uniprotkb:P36957 intact:EBI-725300|intact:EBI-1263554|uniprotkb:Q5XKQ1|uniprotkb:Q7Z3W7|uniprotkb:Q8N5B9|uniprotkb:Q9BZR1|uniprotkb:Q9BZR5|uniprotkb:Q9UHX7|uniprotkb:A8MSA1|uniprotkb:B3KMZ1|uniprotkb:B4E3N2|ensembl:ENSP00000366434|ensembl:ENSP00000421926 intact:EBI-351007|uniprotkb:Q9BQ32|uniprotkb:Q7LDY7|intact:EBI-2511564|uniprotkb:B7Z5W8|uniprotkb:E7ESY5|ensembl:ENSP00000335304 psi-mi:uimc1_human(display_long)|uniprotkb:Retinoid X receptor-interacting protein 110(gene name synonym)|uniprotkb:Receptor-associated protein 80(gene name synonym)|uniprotkb:Ubiquitin interaction motif-containing protein 1(gene name synonym)|uniprotkb:UIMC1(gene name)|psi-mi:UIMC1(display_short)|uniprotkb:RAP80(gene name synonym)|uniprotkb:RXRIP110(gene name synonym) psi-mi:odo2_human(display_long)|uniprotkb:DLST(gene name)|psi-mi:DLST(display_short)|uniprotkb:DLTS(gene name synonym)|uniprotkb:Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex(gene name synonym)|uniprotkb:E2K(gene name synonym)|uniprotkb:2-oxoglutarate dehydrogenase complex component E2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515432|imex:IM-12079-48 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001186226.1|refseq:NP_001186227.1|refseq:NP_057374.3|refseq:NP_001304890.1|ensembl:ENSG00000087206(gene)|ensembl:ENST00000377227(transcript)|ensembl:ENST00000511320(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006302"(double-strand break repair)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016604"(nuclear body)|go:"GO:0042393"(histone binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0070531"(BRCA1-A complex)|go:"GO:0070537"(histone H2A K63-linked deubiquitination)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR006642(Zinc finger, Rad18-type putative)|interpro:IPR038868|interpro:IPR040714|mint:Q96RL1|rcsb pdb:2MKF|rcsb pdb:2MKG|rcsb pdb:2N9E|rcsb pdb:2RR9|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473|refseq:XP_005265987.1|refseq:XP_005265993.1|refseq:XP_006714934.1|refseq:XP_016865063.1|refseq:XP_016865067.1|refseq:XP_016865068.1|dip:DIP-29936N refseq:NP_001924.2|ensembl:ENSG00000119689(gene)|ensembl:ENST00000334220(transcript)|go:"GO:0004149"(dihydrolipoyllysine-residue succinyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006091"(generation of precursor metabolites and energy)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006103"(2-oxoglutarate metabolic process)|go:"GO:0006104"(succinyl-CoA metabolic process)|go:"GO:0016020"(membrane)|go:"GO:0016746"(acyltransferase activity)|go:"GO:0033512"(L-lysine catabolic process to acetyl-CoA via saccharopine)|go:"GO:0034451"(centriolar satellite)|go:"GO:0045252"(oxoglutarate dehydrogenase complex)|go:"GO:0106077"(histone succinylation)|interpro:IPR000089(Biotin/lipoyl attachment)|interpro:IPR001078(Catalytic domain of components of various dehydrogenase complexes)|interpro:IPR003016(2-oxo acid dehydrogenase, lipoyl-binding site)|interpro:IPR006255(Dihydrolipoamide succinyltransferase)|interpro:IPR011053(Single hybrid motif)|interpro:IPR023213|mint:P36957|rcsb pdb:6H05|reactome:R-HSA-389661|reactome:R-HSA-71064|reactome:R-HSA-71403 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/10/11 rogid:j5ho+aD4tkX7bXXlROdiprUX1Mc9606 rogid:lZLUcTHB/dxXBTI/IXnSjyuVmBo9606 intact-crc:9F72FD50BF55E39F|rigid:bV4m56+z4dSFYYaXgpVyRQsWti0 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96RL1 refseq:XP_293026 intact:EBI-725300|intact:EBI-1263554|uniprotkb:Q5XKQ1|uniprotkb:Q7Z3W7|uniprotkb:Q8N5B9|uniprotkb:Q9BZR1|uniprotkb:Q9BZR5|uniprotkb:Q9UHX7|uniprotkb:A8MSA1|uniprotkb:B3KMZ1|uniprotkb:B4E3N2|ensembl:ENSP00000366434|ensembl:ENSP00000421926 intact:EBI-2507556 psi-mi:uimc1_human(display_long)|uniprotkb:Retinoid X receptor-interacting protein 110(gene name synonym)|uniprotkb:Receptor-associated protein 80(gene name synonym)|uniprotkb:Ubiquitin interaction motif-containing protein 1(gene name synonym)|uniprotkb:UIMC1(gene name)|psi-mi:UIMC1(display_short)|uniprotkb:RAP80(gene name synonym)|uniprotkb:RXRIP110(gene name synonym) psi-mi:ipi00260209(display_long) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515432|imex:IM-12079-48 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001186226.1|refseq:NP_001186227.1|refseq:NP_057374.3|refseq:NP_001304890.1|ensembl:ENSG00000087206(gene)|ensembl:ENST00000377227(transcript)|ensembl:ENST00000511320(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006302"(double-strand break repair)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016604"(nuclear body)|go:"GO:0042393"(histone binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0070531"(BRCA1-A complex)|go:"GO:0070537"(histone H2A K63-linked deubiquitination)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR006642(Zinc finger, Rad18-type putative)|interpro:IPR038868|interpro:IPR040714|mint:Q96RL1|rcsb pdb:2MKF|rcsb pdb:2MKG|rcsb pdb:2N9E|rcsb pdb:2RR9|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473|refseq:XP_005265987.1|refseq:XP_005265993.1|refseq:XP_006714934.1|refseq:XP_016865063.1|refseq:XP_016865067.1|refseq:XP_016865068.1|dip:DIP-29936N - psi-mi:"MI:0469"(intact) - no-uniprot-update:An amino acid sequence which is not represented in UniProt figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/10/11 rogid:j5ho+aD4tkX7bXXlROdiprUX1Mc9606 rogid:hWim0nfA/5hb01ecQDGjtHLHh/A9606 intact-crc:9F72FD50BF55E39F|rigid:bV4m56+z4dSFYYaXgpVyRQsWti0 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96RL1 uniprotkb:Q6UWZ7 intact:EBI-725300|intact:EBI-1263554|uniprotkb:Q5XKQ1|uniprotkb:Q7Z3W7|uniprotkb:Q8N5B9|uniprotkb:Q9BZR1|uniprotkb:Q9BZR5|uniprotkb:Q9UHX7|uniprotkb:A8MSA1|uniprotkb:B3KMZ1|uniprotkb:B4E3N2|ensembl:ENSP00000366434|ensembl:ENSP00000421926 intact:EBI-1263451|uniprotkb:Q9H8I1|uniprotkb:Q9H9N4|uniprotkb:A5JJ07|ensembl:ENSP00000369857 psi-mi:uimc1_human(display_long)|uniprotkb:Retinoid X receptor-interacting protein 110(gene name synonym)|uniprotkb:Receptor-associated protein 80(gene name synonym)|uniprotkb:Ubiquitin interaction motif-containing protein 1(gene name synonym)|uniprotkb:UIMC1(gene name)|psi-mi:UIMC1(display_short)|uniprotkb:RAP80(gene name synonym)|uniprotkb:RXRIP110(gene name synonym) psi-mi:abrx1_human(display_long)|uniprotkb:ABRAXAS1(gene name)|psi-mi:ABRAXAS1(display_short)|uniprotkb:ABRA1(gene name synonym)|uniprotkb:CCDC98(gene name synonym)|uniprotkb:Coiled-coil domain-containing protein 98(gene name synonym)|uniprotkb:FAM175A(gene name synonym)|uniprotkb:Protein FAM175A(gene name synonym)|uniprotkb:UNQ496/PRO1013(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515432|imex:IM-12079-48 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001186226.1|refseq:NP_001186227.1|refseq:NP_057374.3|refseq:NP_001304890.1|ensembl:ENSG00000087206(gene)|ensembl:ENST00000377227(transcript)|ensembl:ENST00000511320(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006302"(double-strand break repair)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016604"(nuclear body)|go:"GO:0042393"(histone binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0070531"(BRCA1-A complex)|go:"GO:0070537"(histone H2A K63-linked deubiquitination)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR006642(Zinc finger, Rad18-type putative)|interpro:IPR038868|interpro:IPR040714|mint:Q96RL1|rcsb pdb:2MKF|rcsb pdb:2MKG|rcsb pdb:2N9E|rcsb pdb:2RR9|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473|refseq:XP_005265987.1|refseq:XP_005265993.1|refseq:XP_006714934.1|refseq:XP_016865063.1|refseq:XP_016865067.1|refseq:XP_016865068.1|dip:DIP-29936N dip:DIP-29615N|refseq:NP_620775.2|refseq:NP_001332891.1|ensembl:ENSG00000163322(gene)|ensembl:ENST00000321945(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006325"(chromatin organization)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0008017"(microtubule binding)|go:"GO:0008608"(attachment of spindle microtubules to kinetochore)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016604"(nuclear body)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0070531"(BRCA1-A complex)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0090307"(mitotic spindle assembly)|interpro:IPR023238|interpro:IPR023239|interpro:IPR037518|rcsb pdb:4JLU|rcsb pdb:4U4A|rcsb pdb:4Y18|rcsb pdb:4Y2G|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473 psi-mi:"MI:0469"(intact) - caution:This sequence has been withdrawn from Uniprot. figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/10/11 rogid:j5ho+aD4tkX7bXXlROdiprUX1Mc9606 rogid:ZD7wQnqzfRv9owR8/zdgrMP5W6c9606 intact-crc:9F72FD50BF55E39F|rigid:bV4m56+z4dSFYYaXgpVyRQsWti0 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96RL1 uniprotkb:Q9NZM5 intact:EBI-725300|intact:EBI-1263554|uniprotkb:Q5XKQ1|uniprotkb:Q7Z3W7|uniprotkb:Q8N5B9|uniprotkb:Q9BZR1|uniprotkb:Q9BZR5|uniprotkb:Q9UHX7|uniprotkb:A8MSA1|uniprotkb:B3KMZ1|uniprotkb:B4E3N2|ensembl:ENSP00000366434|ensembl:ENSP00000421926 intact:EBI-720156|uniprotkb:Q9BTC6|uniprotkb:Q9HAX6|uniprotkb:Q9NPP1|uniprotkb:Q9NPR4|uniprotkb:Q9UFI2|ensembl:ENSP00000246802 psi-mi:uimc1_human(display_long)|uniprotkb:Retinoid X receptor-interacting protein 110(gene name synonym)|uniprotkb:Receptor-associated protein 80(gene name synonym)|uniprotkb:Ubiquitin interaction motif-containing protein 1(gene name synonym)|uniprotkb:UIMC1(gene name)|psi-mi:UIMC1(display_short)|uniprotkb:RAP80(gene name synonym)|uniprotkb:RXRIP110(gene name synonym) psi-mi:nop53_human(display_long)|uniprotkb:NOP53(gene name)|psi-mi:NOP53(display_short)|uniprotkb:GLT(gene name synonym)|uniprotkb:GLTSCR2(gene name synonym)|uniprotkb:Glioma tumor suppressor candidate region gene 2 protein(gene name synonym)|uniprotkb:PICT1(gene name synonym)|uniprotkb:Protein interacting with carboxyl terminus 1(gene name synonym)|uniprotkb:p60(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515432|imex:IM-12079-48 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001186226.1|refseq:NP_001186227.1|refseq:NP_057374.3|refseq:NP_001304890.1|ensembl:ENSG00000087206(gene)|ensembl:ENST00000377227(transcript)|ensembl:ENST00000511320(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006302"(double-strand break repair)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016604"(nuclear body)|go:"GO:0042393"(histone binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0070531"(BRCA1-A complex)|go:"GO:0070537"(histone H2A K63-linked deubiquitination)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR006642(Zinc finger, Rad18-type putative)|interpro:IPR038868|interpro:IPR040714|mint:Q96RL1|rcsb pdb:2MKF|rcsb pdb:2MKG|rcsb pdb:2N9E|rcsb pdb:2RR9|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473|refseq:XP_005265987.1|refseq:XP_005265993.1|refseq:XP_006714934.1|refseq:XP_016865063.1|refseq:XP_016865067.1|refseq:XP_016865068.1|dip:DIP-29936N refseq:NP_056525.2|ensembl:ENSG00000105373(gene)|ensembl:ENST00000246802(transcript)|go:"GO:0000027"(ribosomal large subunit assembly)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001650"(fibrillar center)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0002039"(p53 binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006364"(rRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0008097"(5S rRNA binding)|go:"GO:0014067"(negative regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0039535"(regulation of RIG-I signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0003723"(RNA binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1901797"(negative regulation of signal transduction by p53 class mediator)|go:"GO:1901837"(negative regulation of transcription of nucleolar large rRNA by RNA polymerase I)|go:"GO:1902570"(protein localization to nucleolus)|go:"GO:1903006"(positive regulation of protein K63-linked deubiquitination)|go:"GO:1903715"(regulation of aerobic respiration)|go:"GO:1990173"(protein localization to nucleoplasm)|interpro:IPR011687(P60-like)|mint:Q9NZM5|go:"GO:0050821"(protein stabilization) psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/10/11 rogid:j5ho+aD4tkX7bXXlROdiprUX1Mc9606 rogid:64EYf68f9eP9SfPBJhjbxuJcn2g9606 intact-crc:9F72FD50BF55E39F|rigid:bV4m56+z4dSFYYaXgpVyRQsWti0 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96RL1 uniprotkb:Q9NP77 intact:EBI-725300|intact:EBI-1263554|uniprotkb:Q5XKQ1|uniprotkb:Q7Z3W7|uniprotkb:Q8N5B9|uniprotkb:Q9BZR1|uniprotkb:Q9BZR5|uniprotkb:Q9UHX7|uniprotkb:A8MSA1|uniprotkb:B3KMZ1|uniprotkb:B4E3N2|ensembl:ENSP00000366434|ensembl:ENSP00000421926 intact:EBI-2515416|ensembl:ENSP00000291386|uniprotkb:Q9H933|uniprotkb:Q9BZS6 psi-mi:uimc1_human(display_long)|uniprotkb:Retinoid X receptor-interacting protein 110(gene name synonym)|uniprotkb:Receptor-associated protein 80(gene name synonym)|uniprotkb:Ubiquitin interaction motif-containing protein 1(gene name synonym)|uniprotkb:UIMC1(gene name)|psi-mi:UIMC1(display_short)|uniprotkb:RAP80(gene name synonym)|uniprotkb:RXRIP110(gene name synonym) psi-mi:ssu72_human(display_long)|uniprotkb:SSU72(gene name)|psi-mi:SSU72(display_short)|uniprotkb:HSPC182(orf name)|uniprotkb:PNAS-120(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515432|imex:IM-12079-48 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001186226.1|refseq:NP_001186227.1|refseq:NP_057374.3|refseq:NP_001304890.1|ensembl:ENSG00000087206(gene)|ensembl:ENST00000377227(transcript)|ensembl:ENST00000511320(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006302"(double-strand break repair)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016604"(nuclear body)|go:"GO:0042393"(histone binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0070531"(BRCA1-A complex)|go:"GO:0070537"(histone H2A K63-linked deubiquitination)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR006642(Zinc finger, Rad18-type putative)|interpro:IPR038868|interpro:IPR040714|mint:Q96RL1|rcsb pdb:2MKF|rcsb pdb:2MKG|rcsb pdb:2N9E|rcsb pdb:2RR9|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473|refseq:XP_005265987.1|refseq:XP_005265993.1|refseq:XP_006714934.1|refseq:XP_016865063.1|refseq:XP_016865067.1|refseq:XP_016865068.1|dip:DIP-29936N ensembl:ENSG00000160075(gene)|ensembl:ENST00000291386(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005847"(mRNA cleavage and polyadenylation specificity factor complex)|go:"GO:0006369"(termination of RNA polymerase II transcription)|go:"GO:0006378"(mRNA polyadenylation)|go:"GO:0008420"(RNA polymerase II CTD heptapeptide repeat phosphatase activity)|go:"GO:0070940"(dephosphorylation of RNA polymerase II C-terminal domain)|go:"GO:0106306"|go:"GO:0106307"|interpro:IPR006811(Ssu72-like protein)|rcsb pdb:3O2Q|rcsb pdb:3O2S|rcsb pdb:4H3H|rcsb pdb:4H3K|reactome:R-HSA-6807505|refseq:NP_054907.1|dip:DIP-53666N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/10/11 rogid:j5ho+aD4tkX7bXXlROdiprUX1Mc9606 rogid:v/C7oHkhi8bmjogExGZj/QI3TO49606 intact-crc:9F72FD50BF55E39F|rigid:bV4m56+z4dSFYYaXgpVyRQsWti0 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96RL1 uniprotkb:P20248 intact:EBI-725300|intact:EBI-1263554|uniprotkb:Q5XKQ1|uniprotkb:Q7Z3W7|uniprotkb:Q8N5B9|uniprotkb:Q9BZR1|uniprotkb:Q9BZR5|uniprotkb:Q9UHX7|uniprotkb:A8MSA1|uniprotkb:B3KMZ1|uniprotkb:B4E3N2|ensembl:ENSP00000366434|ensembl:ENSP00000421926 intact:EBI-457097|ensembl:ENSP00000274026|uniprotkb:Q2M3U6|uniprotkb:Q4W5P4|uniprotkb:Q6LER8|uniprotkb:A8K7B6 psi-mi:uimc1_human(display_long)|uniprotkb:Retinoid X receptor-interacting protein 110(gene name synonym)|uniprotkb:Receptor-associated protein 80(gene name synonym)|uniprotkb:Ubiquitin interaction motif-containing protein 1(gene name synonym)|uniprotkb:UIMC1(gene name)|psi-mi:UIMC1(display_short)|uniprotkb:RAP80(gene name synonym)|uniprotkb:RXRIP110(gene name synonym) psi-mi:ccna2_human(display_long)|uniprotkb:Cyclin A(gene name synonym)|uniprotkb:CCNA2(gene name)|psi-mi:CCNA2(display_short)|uniprotkb:CCN1(gene name synonym)|uniprotkb:CCNA(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515432|imex:IM-12079-48 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001186226.1|refseq:NP_001186227.1|refseq:NP_057374.3|refseq:NP_001304890.1|ensembl:ENSG00000087206(gene)|ensembl:ENST00000377227(transcript)|ensembl:ENST00000511320(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006302"(double-strand break repair)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016604"(nuclear body)|go:"GO:0042393"(histone binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0070531"(BRCA1-A complex)|go:"GO:0070537"(histone H2A K63-linked deubiquitination)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR006642(Zinc finger, Rad18-type putative)|interpro:IPR038868|interpro:IPR040714|mint:Q96RL1|rcsb pdb:2MKF|rcsb pdb:2MKG|rcsb pdb:2N9E|rcsb pdb:2RR9|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473|refseq:XP_005265987.1|refseq:XP_005265993.1|refseq:XP_006714934.1|refseq:XP_016865063.1|refseq:XP_016865067.1|refseq:XP_016865068.1|dip:DIP-29936N ensembl:ENSG00000145386(gene)|ensembl:ENST00000274026(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0001939"(female pronucleus)|go:"GO:0001940"(male pronucleus)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0016572"(histone phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0033762"(response to glucagon)|refseq:NP_001228.1|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0044772"(mitotic cell cycle phase transition)|go:"GO:0044843"(cell cycle G1/S phase transition)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0051301"(cell division)|go:"GO:0071314"(cellular response to cocaine)|go:"GO:0071373"(cellular response to luteinizing hormone stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0090102"(cochlea development)|go:"GO:0097124"(cyclin A2-CDK2 complex)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|interpro:IPR004367(Cyclin, C-terminal)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR013763(Cyclin-related)|interpro:IPR032447|interpro:IPR036915|interpro:IPR039361|mint:P20248|rcsb pdb:1E9H|rcsb pdb:1FIN|rcsb pdb:1H1P|rcsb pdb:1FVV|rcsb pdb:1GY3|rcsb pdb:1H1Q|rcsb pdb:1H1R|rcsb pdb:1H1S|rcsb pdb:1H24|rcsb pdb:1H25|rcsb pdb:1H26|rcsb pdb:1H27|rcsb pdb:1H28|rcsb pdb:1JST|rcsb pdb:1JSU|rcsb pdb:1OGU|rcsb pdb:1OI9|rcsb pdb:1OIU|rcsb pdb:1OIY|rcsb pdb:1OKV|rcsb pdb:1OKW|rcsb pdb:1OL1|rcsb pdb:1OL2|rcsb pdb:1P5E|rcsb pdb:1PKD|rcsb pdb:1QMZ|rcsb pdb:1URC|rcsb pdb:1VYW|rcsb pdb:2BKZ|rcsb pdb:2BPM|rcsb pdb:2C4G|rcsb pdb:6SG4|rcsb pdb:7ACK|rcsb pdb:7B5L|rcsb pdb:7B5R|rcsb pdb:7LUO|reactome:R-HSA-1362300|reactome:R-HSA-1538133|reactome:R-HSA-170145|reactome:R-HSA-171319|reactome:R-HSA-174184|reactome:R-HSA-176408|reactome:R-HSA-187577|reactome:R-HSA-2559582|reactome:R-HSA-2559586|reactome:R-HSA-5689880|reactome:R-HSA-5693607|reactome:R-HSA-6804116|reactome:R-HSA-6804756|reactome:R-HSA-6804757|rcsb pdb:2C5N|rcsb pdb:2C5O|rcsb pdb:2C5V|rcsb pdb:2C5X|rcsb pdb:2C6T|rcsb pdb:2CCH|rcsb pdb:2CCI|rcsb pdb:2CJM|rcsb pdb:2WIH|rcsb pdb:2I40|rcsb pdb:2IW6|rcsb pdb:2IW8|rcsb pdb:2IW9|rcsb pdb:2UUE|rcsb pdb:2WIP|rcsb pdb:2WMA|rcsb pdb:2WMB|rcsb pdb:2WPA|rcsb pdb:2WXV|rcsb pdb:2X1N|rcsb pdb:3EID|rcsb pdb:3EJ1|rcsb pdb:3EOC|rcsb pdb:3F5X|rcsb pdb:4BCK|rcsb pdb:2UZB|rcsb pdb:2UZD|rcsb pdb:2UZE|rcsb pdb:2UZL|rcsb pdb:2V22|rcsb pdb:2WEV|rcsb pdb:2WFY|rcsb pdb:2WHB|rcsb pdb:4BCM|rcsb pdb:4BCN|rcsb pdb:4BCP|rcsb pdb:4CFM|rcsb pdb:4CFN|rcsb pdb:4CFU|rcsb pdb:4CFV|rcsb pdb:4CFW|rcsb pdb:4CFX|rcsb pdb:4EOI|rcsb pdb:4EOJ|rcsb pdb:4EOK|rcsb pdb:4EOL|rcsb pdb:4EOM|rcsb pdb:4EON|rcsb pdb:4EOO|rcsb pdb:4EOP|rcsb pdb:6Q6H|rcsb pdb:4EOQ|rcsb pdb:4EOR|rcsb pdb:4EOS|rcsb pdb:4FX3|rcsb pdb:5CYI|rcsb pdb:5IF1|rcsb pdb:5LMK|rcsb pdb:5NEV|rcsb pdb:6ATH|rcsb pdb:6RIJ|rcsb pdb:6GVA|rcsb pdb:6P3W|rcsb pdb:6Q6G|reactome:R-HSA-68911|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69273|reactome:R-HSA-69563|reactome:R-HSA-69656|dip:DIP-638N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/10/11 rogid:j5ho+aD4tkX7bXXlROdiprUX1Mc9606 rogid:eAkF93loT7w//7jrIC/Nlpy5iVc9606 intact-crc:9F72FD50BF55E39F|rigid:bV4m56+z4dSFYYaXgpVyRQsWti0 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96RL1 uniprotkb:Q9BS26 intact:EBI-725300|intact:EBI-1263554|uniprotkb:Q5XKQ1|uniprotkb:Q7Z3W7|uniprotkb:Q8N5B9|uniprotkb:Q9BZR1|uniprotkb:Q9BZR5|uniprotkb:Q9UHX7|uniprotkb:A8MSA1|uniprotkb:B3KMZ1|uniprotkb:B4E3N2|ensembl:ENSP00000366434|ensembl:ENSP00000421926 intact:EBI-541644|uniprotkb:O60319|uniprotkb:Q5VWZ7|uniprotkb:Q6UW14|uniprotkb:Q8WX67|intact:EBI-1054855|uniprotkb:Q4VXC1|ensembl:ENSP00000262455 psi-mi:uimc1_human(display_long)|uniprotkb:Retinoid X receptor-interacting protein 110(gene name synonym)|uniprotkb:Receptor-associated protein 80(gene name synonym)|uniprotkb:Ubiquitin interaction motif-containing protein 1(gene name synonym)|uniprotkb:UIMC1(gene name)|psi-mi:UIMC1(display_short)|uniprotkb:RAP80(gene name synonym)|uniprotkb:RXRIP110(gene name synonym) psi-mi:erp44_human(display_long)|uniprotkb:ERP44(gene name)|psi-mi:ERP44(display_short)|uniprotkb:UNQ532/PRO1075(orf name)|uniprotkb:TXNDC4(gene name synonym)|uniprotkb:Thioredoxin domain-containing protein 4(gene name synonym)|uniprotkb:KIAA0573(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515432|imex:IM-12079-48 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001186226.1|refseq:NP_001186227.1|refseq:NP_057374.3|refseq:NP_001304890.1|ensembl:ENSG00000087206(gene)|ensembl:ENST00000377227(transcript)|ensembl:ENST00000511320(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006302"(double-strand break repair)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016604"(nuclear body)|go:"GO:0042393"(histone binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0070531"(BRCA1-A complex)|go:"GO:0070537"(histone H2A K63-linked deubiquitination)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR006642(Zinc finger, Rad18-type putative)|interpro:IPR038868|interpro:IPR040714|mint:Q96RL1|rcsb pdb:2MKF|rcsb pdb:2MKG|rcsb pdb:2N9E|rcsb pdb:2RR9|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473|refseq:XP_005265987.1|refseq:XP_005265993.1|refseq:XP_006714934.1|refseq:XP_016865063.1|refseq:XP_016865067.1|refseq:XP_016865068.1|dip:DIP-29936N ensembl:ENSG00000023318(gene)|ensembl:ENST00000262455(transcript)|go:"GO:0003756"(protein disulfide isomerase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0006457"(protein folding)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0009986"(cell surface)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035580"(specific granule lumen)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0070062"(extracellular exosome)|interpro:IPR013766(Thioredoxin domain)|interpro:IPR036249|interpro:IPR041862|interpro:IPR041870|mint:Q9BS26|rcsb pdb:2R2J|rcsb pdb:5GU6|rcsb pdb:5GU7|rcsb pdb:5HQP|rcsb pdb:5XWM|reactome:R-HSA-6798695|go:"GO:0009100"(glycoprotein metabolic process)|refseq:NP_055866.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/10/11 rogid:j5ho+aD4tkX7bXXlROdiprUX1Mc9606 rogid:TpwaFRifveb03iRPS2pEZve1kLA9606 intact-crc:9F72FD50BF55E39F|rigid:bV4m56+z4dSFYYaXgpVyRQsWti0 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96RL1 uniprotkb:Q99829 intact:EBI-725300|intact:EBI-1263554|uniprotkb:Q5XKQ1|uniprotkb:Q7Z3W7|uniprotkb:Q8N5B9|uniprotkb:Q9BZR1|uniprotkb:Q9BZR5|uniprotkb:Q9UHX7|uniprotkb:A8MSA1|uniprotkb:B3KMZ1|uniprotkb:B4E3N2|ensembl:ENSP00000366434|ensembl:ENSP00000421926 intact:EBI-1642542|uniprotkb:E1P5Q4|uniprotkb:Q6IBL3|uniprotkb:Q9H243|uniprotkb:Q9NTZ7|ensembl:ENSP00000336945|ensembl:ENSP00000380585 psi-mi:uimc1_human(display_long)|uniprotkb:Retinoid X receptor-interacting protein 110(gene name synonym)|uniprotkb:Receptor-associated protein 80(gene name synonym)|uniprotkb:Ubiquitin interaction motif-containing protein 1(gene name synonym)|uniprotkb:UIMC1(gene name)|psi-mi:UIMC1(display_short)|uniprotkb:RAP80(gene name synonym)|uniprotkb:RXRIP110(gene name synonym) psi-mi:cpne1_human(display_long)|uniprotkb:CPNE1(gene name)|psi-mi:CPNE1(display_short)|uniprotkb:CPN1(gene name synonym)|uniprotkb:Copine I(gene name synonym)|uniprotkb:Chromobindin 17(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515432|imex:IM-12079-48 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001186226.1|refseq:NP_001186227.1|refseq:NP_057374.3|refseq:NP_001304890.1|ensembl:ENSG00000087206(gene)|ensembl:ENST00000377227(transcript)|ensembl:ENST00000511320(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006302"(double-strand break repair)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016604"(nuclear body)|go:"GO:0042393"(histone binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0070531"(BRCA1-A complex)|go:"GO:0070537"(histone H2A K63-linked deubiquitination)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR006642(Zinc finger, Rad18-type putative)|interpro:IPR038868|interpro:IPR040714|mint:Q96RL1|rcsb pdb:2MKF|rcsb pdb:2MKG|rcsb pdb:2N9E|rcsb pdb:2RR9|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473|refseq:XP_005265987.1|refseq:XP_005265993.1|refseq:XP_006714934.1|refseq:XP_016865063.1|refseq:XP_016865067.1|refseq:XP_016865068.1|dip:DIP-29936N refseq:NP_003906.2|refseq:NP_690902.1|refseq:NP_690903.1|refseq:NP_690904.1|refseq:NP_690905.1|ensembl:ENSG00000214078(gene)|ensembl:ENST00000352393(transcript)|ensembl:ENST00000397443(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0004175"(endopeptidase activity)|go:"GO:0005215"(transporter activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005544"(calcium-dependent phospholipid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0031965"(nuclear membrane)|go:"GO:0035577"(azurophil granule membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:1990138"(neuron projection extension)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR010734(Copine)|interpro:IPR035892|interpro:IPR036465|interpro:IPR037768|mint:Q99829|reactome:R-HSA-1483206|reactome:R-HSA-6798695 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/10/11 rogid:j5ho+aD4tkX7bXXlROdiprUX1Mc9606 rogid:Mtq9BQZT1fdT+JigvKinqBWAh9w9606 intact-crc:9F72FD50BF55E39F|rigid:bV4m56+z4dSFYYaXgpVyRQsWti0 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96RL1 uniprotkb:P02768 intact:EBI-725300|intact:EBI-1263554|uniprotkb:Q5XKQ1|uniprotkb:Q7Z3W7|uniprotkb:Q8N5B9|uniprotkb:Q9BZR1|uniprotkb:Q9BZR5|uniprotkb:Q9UHX7|uniprotkb:A8MSA1|uniprotkb:B3KMZ1|uniprotkb:B4E3N2|ensembl:ENSP00000366434|ensembl:ENSP00000421926 intact:EBI-714423|ensembl:ENSP00000295897|uniprotkb:Q645G4|uniprotkb:O95574|uniprotkb:P04277|uniprotkb:Q13140|uniprotkb:Q68DN5|uniprotkb:Q6UXK4|uniprotkb:Q86YG0|uniprotkb:Q9P157|uniprotkb:Q9P1I7|uniprotkb:Q9UHS3|uniprotkb:Q9UJZ0|intact:EBI-7301844|intact:MINT-1161169|uniprotkb:E7ESS9|uniprotkb:Q8IUK7 psi-mi:uimc1_human(display_long)|uniprotkb:Retinoid X receptor-interacting protein 110(gene name synonym)|uniprotkb:Receptor-associated protein 80(gene name synonym)|uniprotkb:Ubiquitin interaction motif-containing protein 1(gene name synonym)|uniprotkb:UIMC1(gene name)|psi-mi:UIMC1(display_short)|uniprotkb:RAP80(gene name synonym)|uniprotkb:RXRIP110(gene name synonym) psi-mi:albu_human(display_long)|uniprotkb:GIG42(orf name)|uniprotkb:ALB(gene name)|psi-mi:ALB(display_short)|uniprotkb:PRO0903(orf name)|uniprotkb:PRO1708(orf name)|uniprotkb:PRO2044(orf name)|uniprotkb:PRO2619(orf name)|uniprotkb:PRO2675(orf name)|uniprotkb:UNQ696/PRO1341(orf name)|uniprotkb:GIG20(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515432|imex:IM-12079-48 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001186226.1|refseq:NP_001186227.1|refseq:NP_057374.3|refseq:NP_001304890.1|ensembl:ENSG00000087206(gene)|ensembl:ENST00000377227(transcript)|ensembl:ENST00000511320(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006302"(double-strand break repair)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016604"(nuclear body)|go:"GO:0042393"(histone binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0070531"(BRCA1-A complex)|go:"GO:0070537"(histone H2A K63-linked deubiquitination)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR006642(Zinc finger, Rad18-type putative)|interpro:IPR038868|interpro:IPR040714|mint:Q96RL1|rcsb pdb:2MKF|rcsb pdb:2MKG|rcsb pdb:2N9E|rcsb pdb:2RR9|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473|refseq:XP_005265987.1|refseq:XP_005265993.1|refseq:XP_006714934.1|refseq:XP_016865063.1|refseq:XP_016865067.1|refseq:XP_016865068.1|dip:DIP-29936N ensembl:ENSG00000163631(gene)|ensembl:ENST00000295897(transcript)|go:"GO:0001895"(retina homeostasis)|go:"GO:0003677"(DNA binding)|go:"GO:0005504"(fatty acid binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|rcsb pdb:1E78|go:"GO:0005634"(nucleus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0015643"(toxic substance binding)|go:"GO:0016209"(antioxidant activity)|go:"GO:0030170"(pyridoxal phosphate binding)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043069"(negative regulation of programmed cell death)|go:"GO:0051087"(chaperone binding)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0051659"(maintenance of mitochondrion location)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0140272"(exogenous protein binding)|go:"GO:1903981"(enterobactin binding)|interpro:IPR000264(Serum albumin)|interpro:IPR014760(Serum albumin, N-terminal)|interpro:IPR020857|interpro:IPR020858|interpro:IPR021177|mint:P02768|rcsb pdb:1AO6|rcsb pdb:1BJ5|rcsb pdb:1BKE|rcsb pdb:1BM0|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|rcsb pdb:6XV0|rcsb pdb:6YG9|rcsb pdb:6ZL1|rcsb pdb:7A9C|rcsb pdb:7AAE|rcsb pdb:7AAI|rcsb pdb:7D6J|rcsb pdb:7JWN|reactome:R-HSA-114608|reactome:R-HSA-159418|reactome:R-HSA-189451|reactome:R-HSA-189483|reactome:R-HSA-2168880|reactome:R-HSA-381426|reactome:R-HSA-879518|reactome:R-HSA-8957275|reactome:R-HSA-8964058|reactome:R-HSA-9707564|rcsb pdb:6WUW|rcsb pdb:1E7B|rcsb pdb:1E7C|rcsb pdb:1E7E|rcsb pdb:1E7F|rcsb pdb:1E7G|rcsb pdb:1E7H|rcsb pdb:1E7I|rcsb pdb:1GNI|rcsb pdb:1GNJ|rcsb pdb:1H9Z|rcsb pdb:1HA2|rcsb pdb:1HK1|rcsb pdb:1HK2|rcsb pdb:1HK3|rcsb pdb:1HK4|rcsb pdb:1HK5|rcsb pdb:1N5U|rcsb pdb:1O9X|rcsb pdb:1TF0|rcsb pdb:1UOR|rcsb pdb:1YSX|rcsb pdb:2BX8|rcsb pdb:2BXA|rcsb pdb:2BXB|rcsb pdb:2BXC|rcsb pdb:2BXD|rcsb pdb:1E7A|rcsb pdb:2BXE|rcsb pdb:2BXF|rcsb pdb:2BXG|rcsb pdb:2BXH|rcsb pdb:2BXI|rcsb pdb:2BXK|rcsb pdb:2BXL|rcsb pdb:2BXM|rcsb pdb:2BXN|rcsb pdb:2BXO|rcsb pdb:2BXP|rcsb pdb:2BXQ|rcsb pdb:2ESG|rcsb pdb:2I2Z|rcsb pdb:2I30|rcsb pdb:2N0X|rcsb pdb:2VDB|rcsb pdb:2VUE|rcsb pdb:2VUF|rcsb pdb:2XSI|rcsb pdb:2XVQ|rcsb pdb:2XVU|rcsb pdb:2XVV|rcsb pdb:2XVW|rcsb pdb:2XW0|rcsb pdb:2XW1|rcsb pdb:2YDF|rcsb pdb:3A73|rcsb pdb:3B9L|rcsb pdb:3B9M|rcsb pdb:3CX9|rcsb pdb:3JQZ|rcsb pdb:3JRY|rcsb pdb:3LU6|rcsb pdb:4HGM|rcsb pdb:4IW1|rcsb pdb:4IW2|rcsb pdb:4K2C|rcsb pdb:4K71|rcsb pdb:4L8U|rcsb pdb:4L9K|rcsb pdb:4L9Q|rcsb pdb:4LA0|rcsb pdb:4LB2|rcsb pdb:4LB9|rcsb pdb:4N0F|rcsb pdb:4N0U|rcsb pdb:4S1Y|rcsb pdb:4Z69|rcsb pdb:5FUO|rcsb pdb:5GIX|rcsb pdb:5GIY|rcsb pdb:5ID7|rcsb pdb:5IFO|rcsb pdb:5IJF|rcsb pdb:5UJB|rcsb pdb:5VNW|rcsb pdb:5X52|rcsb pdb:5YB1|rcsb pdb:5YOQ|rcsb pdb:5Z0B|rcsb pdb:6A7P|rcsb pdb:6EZQ|rcsb pdb:6HSC|rcsb pdb:6JE7|rcsb pdb:6L4K|rcsb pdb:6M4R|rcsb pdb:3LU7|rcsb pdb:3LU8|rcsb pdb:3SQJ|rcsb pdb:3TDL|rcsb pdb:3UIV|rcsb pdb:4BKE|rcsb pdb:4E99|rcsb pdb:4EMX|rcsb pdb:4G03|rcsb pdb:4G04|rcsb pdb:4HGK|rcsb pdb:6M58|rcsb pdb:6M5D|rcsb pdb:6M5E|rcsb pdb:6QIO|rcsb pdb:6QIP|rcsb pdb:6R7S|refseq:NP_000468.1|dip:DIP-29902N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/10/11 rogid:j5ho+aD4tkX7bXXlROdiprUX1Mc9606 rogid:kjtn5mBsCZz/NRkcyW5k3ZWeJBU9606 intact-crc:9F72FD50BF55E39F|rigid:bV4m56+z4dSFYYaXgpVyRQsWti0 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96RL1 uniprotkb:O15067 intact:EBI-725300|intact:EBI-1263554|uniprotkb:Q5XKQ1|uniprotkb:Q7Z3W7|uniprotkb:Q8N5B9|uniprotkb:Q9BZR1|uniprotkb:Q9BZR5|uniprotkb:Q9UHX7|uniprotkb:A8MSA1|uniprotkb:B3KMZ1|uniprotkb:B4E3N2|ensembl:ENSP00000366434|ensembl:ENSP00000421926 intact:EBI-1052653|uniprotkb:A6H8V8|ensembl:ENSP00000313490 psi-mi:uimc1_human(display_long)|uniprotkb:Retinoid X receptor-interacting protein 110(gene name synonym)|uniprotkb:Receptor-associated protein 80(gene name synonym)|uniprotkb:Ubiquitin interaction motif-containing protein 1(gene name synonym)|uniprotkb:UIMC1(gene name)|psi-mi:UIMC1(display_short)|uniprotkb:RAP80(gene name synonym)|uniprotkb:RXRIP110(gene name synonym) psi-mi:pur4_human(display_long)|uniprotkb:Formylglycinamide ribotide amidotransferase(gene name synonym)|uniprotkb:PFAS(gene name)|psi-mi:PFAS(display_short)|uniprotkb:KIAA0361(gene name synonym)|uniprotkb:Formylglycinamide ribonucleotide amidotransferase(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515432|imex:IM-12079-48 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001186226.1|refseq:NP_001186227.1|refseq:NP_057374.3|refseq:NP_001304890.1|ensembl:ENSG00000087206(gene)|ensembl:ENST00000377227(transcript)|ensembl:ENST00000511320(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006302"(double-strand break repair)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016604"(nuclear body)|go:"GO:0042393"(histone binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0070531"(BRCA1-A complex)|go:"GO:0070537"(histone H2A K63-linked deubiquitination)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR006642(Zinc finger, Rad18-type putative)|interpro:IPR038868|interpro:IPR040714|mint:Q96RL1|rcsb pdb:2MKF|rcsb pdb:2MKG|rcsb pdb:2N9E|rcsb pdb:2RR9|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473|refseq:XP_005265987.1|refseq:XP_005265993.1|refseq:XP_006714934.1|refseq:XP_016865063.1|refseq:XP_016865067.1|refseq:XP_016865068.1|dip:DIP-29936N refseq:NP_036525.1|ensembl:ENSG00000178921(gene)|ensembl:ENST00000314666(transcript)|go:"GO:0004642"(phosphoribosylformylglycinamidine synthase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006189"('de novo' IMP biosynthetic process)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0009168"(purine ribonucleoside monophosphate biosynthetic process)|go:"GO:0042493"|go:"GO:0046872"(metal ion binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097065"(anterior head development)|interpro:IPR010073(Phosphoribosylformylglycinamidine synthase, eukaryotes and proteobacteria)|interpro:IPR010918(AIR synthase related protein, C-terminal)|interpro:IPR029062|interpro:IPR036604|interpro:IPR036676|interpro:IPR036921|interpro:IPR040707|interpro:IPR041609|mint:O15067|reactome:R-HSA-73817 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/10/11 rogid:j5ho+aD4tkX7bXXlROdiprUX1Mc9606 rogid:e52AyHjHUrLjnoJP+rInkcvfGJk9606 intact-crc:9F72FD50BF55E39F|rigid:bV4m56+z4dSFYYaXgpVyRQsWti0 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96RL1 uniprotkb:Q8IZK2 intact:EBI-725300|intact:EBI-1263554|uniprotkb:Q5XKQ1|uniprotkb:Q7Z3W7|uniprotkb:Q8N5B9|uniprotkb:Q9BZR1|uniprotkb:Q9BZR5|uniprotkb:Q9UHX7|uniprotkb:A8MSA1|uniprotkb:B3KMZ1|uniprotkb:B4E3N2|ensembl:ENSP00000366434|ensembl:ENSP00000421926 intact:EBI-2515428 psi-mi:uimc1_human(display_long)|uniprotkb:Retinoid X receptor-interacting protein 110(gene name synonym)|uniprotkb:Receptor-associated protein 80(gene name synonym)|uniprotkb:Ubiquitin interaction motif-containing protein 1(gene name synonym)|uniprotkb:UIMC1(gene name)|psi-mi:UIMC1(display_short)|uniprotkb:RAP80(gene name synonym)|uniprotkb:RXRIP110(gene name synonym) psi-mi:q8izk2_human(display_long)|uniprotkb:BRCA1(gene name)|psi-mi:BRCA1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515432|imex:IM-12079-48 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001186226.1|refseq:NP_001186227.1|refseq:NP_057374.3|refseq:NP_001304890.1|ensembl:ENSG00000087206(gene)|ensembl:ENST00000377227(transcript)|ensembl:ENST00000511320(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006302"(double-strand break repair)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016604"(nuclear body)|go:"GO:0042393"(histone binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0070531"(BRCA1-A complex)|go:"GO:0070537"(histone H2A K63-linked deubiquitination)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR006642(Zinc finger, Rad18-type putative)|interpro:IPR038868|interpro:IPR040714|mint:Q96RL1|rcsb pdb:2MKF|rcsb pdb:2MKG|rcsb pdb:2N9E|rcsb pdb:2RR9|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473|refseq:XP_005265987.1|refseq:XP_005265993.1|refseq:XP_006714934.1|refseq:XP_016865063.1|refseq:XP_016865067.1|refseq:XP_016865068.1|dip:DIP-29936N - psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/10/11 rogid:j5ho+aD4tkX7bXXlROdiprUX1Mc9606 rogid:Bok4Ow6jvJlCxqNjMHB7SxsvLxg9606 intact-crc:9F72FD50BF55E39F|rigid:bV4m56+z4dSFYYaXgpVyRQsWti0 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96RL1 uniprotkb:Q9C005 intact:EBI-725300|intact:EBI-1263554|uniprotkb:Q5XKQ1|uniprotkb:Q7Z3W7|uniprotkb:Q8N5B9|uniprotkb:Q9BZR1|uniprotkb:Q9BZR5|uniprotkb:Q9UHX7|uniprotkb:A8MSA1|uniprotkb:B3KMZ1|uniprotkb:B4E3N2|ensembl:ENSP00000366434|ensembl:ENSP00000421926 intact:EBI-744973|uniprotkb:D6W578|ensembl:ENSP00000295066|ensembl:ENSP00000345837 psi-mi:uimc1_human(display_long)|uniprotkb:Retinoid X receptor-interacting protein 110(gene name synonym)|uniprotkb:Receptor-associated protein 80(gene name synonym)|uniprotkb:Ubiquitin interaction motif-containing protein 1(gene name synonym)|uniprotkb:UIMC1(gene name)|psi-mi:UIMC1(display_short)|uniprotkb:RAP80(gene name synonym)|uniprotkb:RXRIP110(gene name synonym) psi-mi:dpy30_human(display_long)|uniprotkb:DPY30(gene name)|psi-mi:DPY30(display_short)|uniprotkb:Dpy-30-like protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515432|imex:IM-12079-48 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001186226.1|refseq:NP_001186227.1|refseq:NP_057374.3|refseq:NP_001304890.1|ensembl:ENSG00000087206(gene)|ensembl:ENST00000377227(transcript)|ensembl:ENST00000511320(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006302"(double-strand break repair)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016604"(nuclear body)|go:"GO:0042393"(histone binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0070531"(BRCA1-A complex)|go:"GO:0070537"(histone H2A K63-linked deubiquitination)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR006642(Zinc finger, Rad18-type putative)|interpro:IPR038868|interpro:IPR040714|mint:Q96RL1|rcsb pdb:2MKF|rcsb pdb:2MKG|rcsb pdb:2N9E|rcsb pdb:2RR9|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473|refseq:XP_005265987.1|refseq:XP_005265993.1|refseq:XP_006714934.1|refseq:XP_016865063.1|refseq:XP_016865067.1|refseq:XP_016865068.1|dip:DIP-29936N refseq:NP_115963.1|ensembl:ENSG00000162961(gene)|ensembl:ENST00000295066(transcript)|ensembl:ENST00000342166(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0006348"|go:"GO:0016197"(endosomal transport)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044666"(MLL3/4 complex)|go:"GO:0048188"(Set1C/COMPASS complex)|go:"GO:0051568"(histone H3-K4 methylation)|interpro:IPR007858(Dpy-30)|interpro:IPR037856|mint:Q9C005|rcsb pdb:3G36|rcsb pdb:4RIQ|rcsb pdb:4RT4|rcsb pdb:4RTA|rcsb pdb:6E2H|rcsb pdb:6PWV|reactome:R-HSA-3214841|reactome:R-HSA-8936459|refseq:NP_001308138.1|dip:DIP-34476N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/10/11 rogid:j5ho+aD4tkX7bXXlROdiprUX1Mc9606 rogid:yC9NJhTfEIT+YyfWRSJLGbRsQkc9606 intact-crc:9F72FD50BF55E39F|rigid:bV4m56+z4dSFYYaXgpVyRQsWti0 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96RL1 uniprotkb:O43847 intact:EBI-725300|intact:EBI-1263554|uniprotkb:Q5XKQ1|uniprotkb:Q7Z3W7|uniprotkb:Q8N5B9|uniprotkb:Q9BZR1|uniprotkb:Q9BZR5|uniprotkb:Q9UHX7|uniprotkb:A8MSA1|uniprotkb:B3KMZ1|uniprotkb:B4E3N2|ensembl:ENSP00000366434|ensembl:ENSP00000421926 intact:EBI-2371631|uniprotkb:O15241|uniprotkb:O15242|uniprotkb:Q5VUL0|uniprotkb:Q96HB2|uniprotkb:Q9NU57|uniprotkb:A6NI41|ensembl:ENSP00000262679|intact:EBI-6137671 psi-mi:uimc1_human(display_long)|uniprotkb:Retinoid X receptor-interacting protein 110(gene name synonym)|uniprotkb:Receptor-associated protein 80(gene name synonym)|uniprotkb:Ubiquitin interaction motif-containing protein 1(gene name synonym)|uniprotkb:UIMC1(gene name)|psi-mi:UIMC1(display_short)|uniprotkb:RAP80(gene name synonym)|uniprotkb:RXRIP110(gene name synonym) psi-mi:nrdc_human(display_long)|uniprotkb:NRDC(gene name)|psi-mi:NRDC(display_short)|uniprotkb:N-arginine dibasic convertase(gene name synonym)|uniprotkb:NRD1(gene name synonym)|uniprotkb:Nardilysin convertase(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515432|imex:IM-12079-48 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001186226.1|refseq:NP_001186227.1|refseq:NP_057374.3|refseq:NP_001304890.1|ensembl:ENSG00000087206(gene)|ensembl:ENST00000377227(transcript)|ensembl:ENST00000511320(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006302"(double-strand break repair)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016604"(nuclear body)|go:"GO:0042393"(histone binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0070531"(BRCA1-A complex)|go:"GO:0070537"(histone H2A K63-linked deubiquitination)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR006642(Zinc finger, Rad18-type putative)|interpro:IPR038868|interpro:IPR040714|mint:Q96RL1|rcsb pdb:2MKF|rcsb pdb:2MKG|rcsb pdb:2N9E|rcsb pdb:2RR9|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473|refseq:XP_005265987.1|refseq:XP_005265993.1|refseq:XP_006714934.1|refseq:XP_016865063.1|refseq:XP_016865067.1|refseq:XP_016865068.1|dip:DIP-29936N refseq:NP_001095132.1|refseq:NP_001229290.1|refseq:NP_002516.2|ensembl:ENSG00000078618(gene)|ensembl:ENST00000352171(transcript)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0009986"(cell surface)|go:"GO:0046872"(metal ion binding)|go:"GO:0048408"(epidermal growth factor binding)|go:"GO:0051044"(positive regulation of membrane protein ectodomain proteolysis)|go:"GO:0052548"(regulation of endopeptidase activity)|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|interpro:IPR001431(Peptidase M16, zinc-binding site)|interpro:IPR007863(Peptidase M16, C-terminal)|interpro:IPR011249(Metalloenzyme, LuxS/M16 peptidase-like, metal-binding)|interpro:IPR011765(Peptidase M16, N-terminal)|interpro:IPR032632|mint:O43847 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/10/11 rogid:j5ho+aD4tkX7bXXlROdiprUX1Mc9606 rogid:zvZTk2Q799M8nsREOYmuYPF/x1U9606 intact-crc:9F72FD50BF55E39F|rigid:bV4m56+z4dSFYYaXgpVyRQsWti0 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96RL1 uniprotkb:Q8TBC4 intact:EBI-725300|intact:EBI-1263554|uniprotkb:Q5XKQ1|uniprotkb:Q7Z3W7|uniprotkb:Q8N5B9|uniprotkb:Q9BZR1|uniprotkb:Q9BZR5|uniprotkb:Q9UHX7|uniprotkb:A8MSA1|uniprotkb:B3KMZ1|uniprotkb:B4E3N2|ensembl:ENSP00000366434|ensembl:ENSP00000421926 intact:EBI-717567|uniprotkb:O76088|uniprotkb:Q9NTU3|uniprotkb:A8K027|intact:EBI-2339745|uniprotkb:A6NLB5|ensembl:ENSP00000354340 psi-mi:uimc1_human(display_long)|uniprotkb:Retinoid X receptor-interacting protein 110(gene name synonym)|uniprotkb:Receptor-associated protein 80(gene name synonym)|uniprotkb:Ubiquitin interaction motif-containing protein 1(gene name synonym)|uniprotkb:UIMC1(gene name)|psi-mi:UIMC1(display_short)|uniprotkb:RAP80(gene name synonym)|uniprotkb:RXRIP110(gene name synonym) psi-mi:uba3_human(display_long)|uniprotkb:Ubiquitin-like modifier-activating enzyme 3(gene name synonym)|uniprotkb:NEDD8-activating enzyme E1C(gene name synonym)|uniprotkb:Ubiquitin-activating enzyme E1C(gene name synonym)|uniprotkb:UBA3(gene name)|psi-mi:UBA3(display_short)|uniprotkb:UBE1C(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515432|imex:IM-12079-48 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001186226.1|refseq:NP_001186227.1|refseq:NP_057374.3|refseq:NP_001304890.1|ensembl:ENSG00000087206(gene)|ensembl:ENST00000377227(transcript)|ensembl:ENST00000511320(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006302"(double-strand break repair)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016604"(nuclear body)|go:"GO:0042393"(histone binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0070531"(BRCA1-A complex)|go:"GO:0070537"(histone H2A K63-linked deubiquitination)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR006642(Zinc finger, Rad18-type putative)|interpro:IPR038868|interpro:IPR040714|mint:Q96RL1|rcsb pdb:2MKF|rcsb pdb:2MKG|rcsb pdb:2N9E|rcsb pdb:2RR9|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473|refseq:XP_005265987.1|refseq:XP_005265993.1|refseq:XP_006714934.1|refseq:XP_016865063.1|refseq:XP_016865067.1|refseq:XP_016865068.1|dip:DIP-29936N refseq:NP_003959.3|refseq:NP_937838.1|ensembl:ENSG00000144744(gene)|ensembl:ENST00000361055(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006508"(proteolysis)|go:"GO:0007113"(endomitotic cell cycle)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019781"(NEDD8 activating enzyme activity)|go:"GO:0019788"(NEDD8 transferase activity)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043687"(post-translational protein modification)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045116"(protein neddylation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR014929(E2 binding)|interpro:IPR023318|interpro:IPR030468|interpro:IPR033127|interpro:IPR035985|mint:Q8TBC4|rcsb pdb:1R4M|rcsb pdb:1R4N|rcsb pdb:1TT5|rcsb pdb:1Y8X|rcsb pdb:1YOV|rcsb pdb:2LQ7|rcsb pdb:2NVU|rcsb pdb:3DBH|rcsb pdb:3DBL|rcsb pdb:3DBR|rcsb pdb:3FN1|rcsb pdb:3GZN|rcsb pdb:5JJM|reactome:R-HSA-5607761|reactome:R-HSA-5676590|reactome:R-HSA-8951664|reactome:R-HSA-983168 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/10/11 rogid:j5ho+aD4tkX7bXXlROdiprUX1Mc9606 rogid:6VcauGap9tDJ780/x06s6QgRr8Y9606 intact-crc:9F72FD50BF55E39F|rigid:bV4m56+z4dSFYYaXgpVyRQsWti0 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96RL1 uniprotkb:B5MD87 intact:EBI-725300|intact:EBI-1263554|uniprotkb:Q5XKQ1|uniprotkb:Q7Z3W7|uniprotkb:Q8N5B9|uniprotkb:Q9BZR1|uniprotkb:Q9BZR5|uniprotkb:Q9UHX7|uniprotkb:A8MSA1|uniprotkb:B3KMZ1|uniprotkb:B4E3N2|ensembl:ENSP00000366434|ensembl:ENSP00000421926 intact:EBI-2514447|ensembl:ENSP00000366802|ensembl:ENSP00000487676 psi-mi:uimc1_human(display_long)|uniprotkb:Retinoid X receptor-interacting protein 110(gene name synonym)|uniprotkb:Receptor-associated protein 80(gene name synonym)|uniprotkb:Ubiquitin interaction motif-containing protein 1(gene name synonym)|uniprotkb:UIMC1(gene name)|psi-mi:UIMC1(display_short)|uniprotkb:RAP80(gene name synonym)|uniprotkb:RXRIP110(gene name synonym) psi-mi:b5md87_human(display_long)|uniprotkb:PYCR3(gene name)|psi-mi:PYCR3(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515432|imex:IM-12079-48 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001186226.1|refseq:NP_001186227.1|refseq:NP_057374.3|refseq:NP_001304890.1|ensembl:ENSG00000087206(gene)|ensembl:ENST00000377227(transcript)|ensembl:ENST00000511320(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006302"(double-strand break repair)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016604"(nuclear body)|go:"GO:0042393"(histone binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0070531"(BRCA1-A complex)|go:"GO:0070537"(histone H2A K63-linked deubiquitination)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR006642(Zinc finger, Rad18-type putative)|interpro:IPR038868|interpro:IPR040714|mint:Q96RL1|rcsb pdb:2MKF|rcsb pdb:2MKG|rcsb pdb:2N9E|rcsb pdb:2RR9|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473|refseq:XP_005265987.1|refseq:XP_005265993.1|refseq:XP_006714934.1|refseq:XP_016865063.1|refseq:XP_016865067.1|refseq:XP_016865068.1|dip:DIP-29936N ensembl:ENSG00000104524(gene)|ensembl:ENST00000377579(transcript)|ensembl:ENST00000634183(transcript)|go:"GO:0004735"(pyrroline-5-carboxylate reductase activity)|go:"GO:0055129"(L-proline biosynthetic process)|interpro:IPR000304(Delta 1-pyrroline-5-carboxylate reductase)|interpro:IPR008927(6-phosphogluconate dehydrogenase, C-terminal-like)|interpro:IPR029036|ensembl:ENSG00000276657(gene) psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/10/11 rogid:j5ho+aD4tkX7bXXlROdiprUX1Mc9606 rogid:gFsOHYTyQNZ93BJH1JNXD5bpX609606 intact-crc:9F72FD50BF55E39F|rigid:bV4m56+z4dSFYYaXgpVyRQsWti0 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q96RL1 uniprotkb:P52907 intact:EBI-725300|intact:EBI-1263554|uniprotkb:Q5XKQ1|uniprotkb:Q7Z3W7|uniprotkb:Q8N5B9|uniprotkb:Q9BZR1|uniprotkb:Q9BZR5|uniprotkb:Q9UHX7|uniprotkb:A8MSA1|uniprotkb:B3KMZ1|uniprotkb:B4E3N2|ensembl:ENSP00000366434|ensembl:ENSP00000421926 intact:EBI-355586|uniprotkb:Q53FQ6|uniprotkb:Q6FHD5|ensembl:ENSP00000263168 psi-mi:uimc1_human(display_long)|uniprotkb:Retinoid X receptor-interacting protein 110(gene name synonym)|uniprotkb:Receptor-associated protein 80(gene name synonym)|uniprotkb:Ubiquitin interaction motif-containing protein 1(gene name synonym)|uniprotkb:UIMC1(gene name)|psi-mi:UIMC1(display_short)|uniprotkb:RAP80(gene name synonym)|uniprotkb:RXRIP110(gene name synonym) psi-mi:caza1_human(display_long)|uniprotkb:CAPZA1(gene name)|psi-mi:CAPZA1(display_short)|uniprotkb:CapZ alpha-1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515432|imex:IM-12079-48 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001186226.1|refseq:NP_001186227.1|refseq:NP_057374.3|refseq:NP_001304890.1|ensembl:ENSG00000087206(gene)|ensembl:ENST00000377227(transcript)|ensembl:ENST00000511320(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006302"(double-strand break repair)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0016604"(nuclear body)|go:"GO:0042393"(histone binding)|go:"GO:0045739"(positive regulation of DNA repair)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0070531"(BRCA1-A complex)|go:"GO:0070537"(histone H2A K63-linked deubiquitination)|interpro:IPR003903(Ubiquitin interacting motif)|interpro:IPR006642(Zinc finger, Rad18-type putative)|interpro:IPR038868|interpro:IPR040714|mint:Q96RL1|rcsb pdb:2MKF|rcsb pdb:2MKG|rcsb pdb:2N9E|rcsb pdb:2RR9|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693571|reactome:R-HSA-5693607|reactome:R-HSA-69473|refseq:XP_005265987.1|refseq:XP_005265993.1|refseq:XP_006714934.1|refseq:XP_016865063.1|refseq:XP_016865067.1|refseq:XP_016865068.1|dip:DIP-29936N refseq:NP_006126.1|ensembl:ENSG00000116489(gene)|ensembl:ENST00000263168(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0008290"(F-actin capping protein complex)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0034329"(cell junction assembly)|go:"GO:0045296"(cadherin binding)|go:"GO:0051015"(actin filament binding)|go:"GO:0051016"(barbed-end actin filament capping)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071203"(WASH complex)|interpro:IPR002189(F-actin capping protein, alpha subunit)|interpro:IPR017865|interpro:IPR037282|interpro:IPR042276|interpro:IPR042489|mint:P52907|rcsb pdb:1MQ1|rcsb pdb:1MWN|reactome:R-HSA-2132295|reactome:R-HSA-3371497|reactome:R-HSA-6807878|reactome:R-HSA-6811436|reactome:R-HSA-879415|reactome:R-HSA-8950505|reactome:R-HSA-9662360|reactome:R-HSA-983231 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/10/11 rogid:j5ho+aD4tkX7bXXlROdiprUX1Mc9606 rogid:97S4WPtjgt4MDLoptRhQ2yH8UNE9606 intact-crc:9F72FD50BF55E39F|rigid:bV4m56+z4dSFYYaXgpVyRQsWti0 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8TBZ3 uniprotkb:Q15527 intact:EBI-2511486|ensembl:ENSP00000341037|uniprotkb:Q8WXX2|uniprotkb:Q9UF86|uniprotkb:Q8NCN7|intact:EBI-11109494|uniprotkb:H0YJJ1|uniprotkb:Q86TU2|uniprotkb:B4DN18|uniprotkb:E7EUY8|uniprotkb:F8W9S4|uniprotkb:G3V2F8|uniprotkb:G3V5R0 intact:EBI-723863|uniprotkb:Q96CD1|ensembl:ENSP00000361032|uniprotkb:Q6IBP9 psi-mi:wdr20_human(display_long)|uniprotkb:WDR20(gene name)|psi-mi:WDR20(display_short)|uniprotkb:Protein DMR(gene name synonym) psi-mi:surf2_human(display_long)|uniprotkb:SURF2(gene name)|psi-mi:SURF2(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515515|imex:IM-12079-99 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000140153(gene)|ensembl:ENST00000342702(transcript)|go:"GO:0005654"(nucleoplasm)|interpro:IPR001680(WD40 repeat)|interpro:IPR036322|mint:Q8TBZ3|rcsb pdb:5K19|rcsb pdb:5K1C|rcsb pdb:6JLQ|reactome:R-HSA-5689880|refseq:NP_001229343.1|refseq:NP_001229345.1|refseq:NP_001229346.1|refseq:NP_001229347.1|refseq:NP_653175.2|refseq:NP_851808.1|refseq:NP_851825.1|refseq:NP_001229344.1 go:"GO:0016607"(nuclear speck)|ensembl:ENSG00000148291(gene)|ensembl:ENST00000371964(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|interpro:IPR008833(Surfeit locus 2)|go:"GO:0005886"(plasma membrane)|refseq:NP_001265857.1|refseq:NP_059973.4 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:2MfZps9YU8xQbWazkq2sIqXjHHg9606 rogid:8uekvF0MDPOEQ3uvvKBCjPR4Uhk9606 intact-crc:8EF7A3D1C62AD212|rigid:k+CJH1A1pcvvsGjo5ra4m2pF0Gs false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8TBZ3 uniprotkb:Q16513 intact:EBI-2511486|ensembl:ENSP00000341037|uniprotkb:Q8WXX2|uniprotkb:Q9UF86|uniprotkb:Q8NCN7|intact:EBI-11109494|uniprotkb:H0YJJ1|uniprotkb:Q86TU2|uniprotkb:B4DN18|uniprotkb:E7EUY8|uniprotkb:F8W9S4|uniprotkb:G3V2F8|uniprotkb:G3V5R0 intact:EBI-2511350|uniprotkb:Q9H1W4|uniprotkb:D3DT24|uniprotkb:B4DQ21|uniprotkb:B4DTP5|uniprotkb:B4DVG1|uniprotkb:Q08AF4|ensembl:ENSP00000359552 psi-mi:wdr20_human(display_long)|uniprotkb:WDR20(gene name)|psi-mi:WDR20(display_short)|uniprotkb:Protein DMR(gene name synonym) psi-mi:pkn2_human(display_long)|uniprotkb:PKN2(gene name)|psi-mi:PKN2(display_short)|uniprotkb:PRK2(gene name synonym)|uniprotkb:PRKCL2(gene name synonym)|uniprotkb:Protein kinase C-like 2(gene name synonym)|uniprotkb:Protein-kinase C-related kinase 2(gene name synonym)|uniprotkb:PKN gamma(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515515|imex:IM-12079-99 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000140153(gene)|ensembl:ENST00000342702(transcript)|go:"GO:0005654"(nucleoplasm)|interpro:IPR001680(WD40 repeat)|interpro:IPR036322|mint:Q8TBZ3|rcsb pdb:5K19|rcsb pdb:5K1C|rcsb pdb:6JLQ|reactome:R-HSA-5689880|refseq:NP_001229343.1|refseq:NP_001229345.1|refseq:NP_001229346.1|refseq:NP_001229347.1|refseq:NP_653175.2|refseq:NP_851808.1|refseq:NP_851825.1|refseq:NP_001229344.1 refseq:XP_011540074.1|refseq:NP_006247.1|refseq:NP_001307636.1|refseq:NP_001307637.1|refseq:NP_001307638.1|ensembl:ENSG00000065243(gene)|ensembl:ENST00000370521(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0010631"(epithelial cell migration)|go:"GO:0016301"(kinase activity)|go:"GO:0016604"(nuclear body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030496"(midbody)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032154"(cleavage furrow)|go:"GO:0005654"(nucleoplasm)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043296"(apical junction complex)|go:"GO:0043297"(apical junction assembly)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045296"(cadherin binding)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051301"(cell division)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000145"(regulation of cell motility)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011072(HR1 rho-binding repeat)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR035892|interpro:IPR036274|interpro:IPR037313|interpro:IPR037784|mint:Q16513|rcsb pdb:4CRS|rcsb pdb:4RRV|rcsb pdb:6CCY|rcsb pdb:6GBE|reactome:R-HSA-5625740|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013149|go:"GO:0032467"(positive regulation of cytokinesis) psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:2MfZps9YU8xQbWazkq2sIqXjHHg9606 rogid:KvHDOJ75CgHIGDC+41jGKORm2+w9606 intact-crc:8EF7A3D1C62AD212|rigid:k+CJH1A1pcvvsGjo5ra4m2pF0Gs false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8TBZ3 uniprotkb:O75317 intact:EBI-2511486|ensembl:ENSP00000341037|uniprotkb:Q8WXX2|uniprotkb:Q9UF86|uniprotkb:Q8NCN7|intact:EBI-11109494|uniprotkb:H0YJJ1|uniprotkb:Q86TU2|uniprotkb:B4DN18|uniprotkb:E7EUY8|uniprotkb:F8W9S4|uniprotkb:G3V2F8|uniprotkb:G3V5R0 intact:EBI-2511507|ensembl:ENSP00000282344|uniprotkb:Q8TC49|uniprotkb:Q5VZV3|uniprotkb:A8K0X0 psi-mi:wdr20_human(display_long)|uniprotkb:WDR20(gene name)|psi-mi:WDR20(display_short)|uniprotkb:Protein DMR(gene name synonym) psi-mi:ubp12_human(display_long)|uniprotkb:USP12(gene name)|psi-mi:USP12(display_short)|uniprotkb:UBH1(gene name synonym)|uniprotkb:USP12L1(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 12(gene name synonym)|uniprotkb:Deubiquitinating enzyme 12(gene name synonym)|uniprotkb:Ubiquitin-hydrolyzing enzyme 1(gene name synonym)|uniprotkb:Ubiquitin thioesterase 12(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515515|imex:IM-12079-99 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000140153(gene)|ensembl:ENST00000342702(transcript)|go:"GO:0005654"(nucleoplasm)|interpro:IPR001680(WD40 repeat)|interpro:IPR036322|mint:Q8TBZ3|rcsb pdb:5K19|rcsb pdb:5K1C|rcsb pdb:6JLQ|reactome:R-HSA-5689880|refseq:NP_001229343.1|refseq:NP_001229345.1|refseq:NP_001229346.1|refseq:NP_001229347.1|refseq:NP_653175.2|refseq:NP_851808.1|refseq:NP_851825.1|refseq:NP_001229344.1 ensembl:ENSG00000152484(gene)|ensembl:ENST00000282344(transcript)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0046872"(metal ion binding)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|mint:O75317|rcsb pdb:5K16|rcsb pdb:5K1A|rcsb pdb:5K1B|rcsb pdb:5K1C|rcsb pdb:5L8W|reactome:R-HSA-5689880|refseq:NP_872294.2 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:2MfZps9YU8xQbWazkq2sIqXjHHg9606 rogid:SiueMBicjAsFl2OGlBfQ6tg1cf89606 intact-crc:8EF7A3D1C62AD212|rigid:k+CJH1A1pcvvsGjo5ra4m2pF0Gs false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8TBZ3 uniprotkb:P13942 intact:EBI-2511486|ensembl:ENSP00000341037|uniprotkb:Q8WXX2|uniprotkb:Q9UF86|uniprotkb:Q8NCN7|intact:EBI-11109494|uniprotkb:H0YJJ1|uniprotkb:Q86TU2|uniprotkb:B4DN18|uniprotkb:E7EUY8|uniprotkb:F8W9S4|uniprotkb:G3V2F8|uniprotkb:G3V5R0 intact:EBI-2515504|ensembl:ENSP00000449275|uniprotkb:Q13271|uniprotkb:Q13272|uniprotkb:Q07751|uniprotkb:Q13273|uniprotkb:Q9UIP9|uniprotkb:Q99866|uniprotkb:Q5JP94|uniprotkb:Q5SUI8|uniprotkb:E7ER90|uniprotkb:A6NLX2|uniprotkb:Q7Z6C3 psi-mi:wdr20_human(display_long)|uniprotkb:WDR20(gene name)|psi-mi:WDR20(display_short)|uniprotkb:Protein DMR(gene name synonym) psi-mi:coba2_human(display_long)|uniprotkb:COL11A2(gene name)|psi-mi:COL11A2(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515515|imex:IM-12079-99 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000140153(gene)|ensembl:ENST00000342702(transcript)|go:"GO:0005654"(nucleoplasm)|interpro:IPR001680(WD40 repeat)|interpro:IPR036322|mint:Q8TBZ3|rcsb pdb:5K19|rcsb pdb:5K1C|rcsb pdb:6JLQ|reactome:R-HSA-5689880|refseq:NP_001229343.1|refseq:NP_001229345.1|refseq:NP_001229346.1|refseq:NP_001229347.1|refseq:NP_653175.2|refseq:NP_851808.1|refseq:NP_851825.1|refseq:NP_001229344.1 ensembl:ENSG00000227801(gene)|ensembl:ENST00000549811(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0005201"(extracellular matrix structural constituent)|go:"GO:0005576"(extracellular region)|go:"GO:0005581"(collagen trimer)|go:"GO:0005592"(collagen type XI trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0030020"(extracellular matrix structural constituent conferring tensile strength)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031012"(extracellular matrix)|go:"GO:0046872"(metal ion binding)|go:"GO:0051216"(cartilage development)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060023"(soft palate development)|go:"GO:0062023"(collagen-containing extracellular matrix)|interpro:IPR001791(Laminin G)|interpro:IPR008160(Collagen triple helix repeat)|interpro:IPR000885(Fibrillar collagen, C-terminal)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|mint:P13942|reactome:R-HSA-1442490|reactome:R-HSA-1650814|reactome:R-HSA-2022090|reactome:R-HSA-3000171|reactome:R-HSA-8874081|reactome:R-HSA-8948216|refseq:XP_016865739.1|refseq:NP_542411.2|refseq:NP_001157243.1|refseq:NP_542412.2 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:2MfZps9YU8xQbWazkq2sIqXjHHg9606 rogid:mYDSrTwgNvGKed3A/wGABGAvSRE9606 intact-crc:8EF7A3D1C62AD212|rigid:k+CJH1A1pcvvsGjo5ra4m2pF0Gs false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8TBZ3 uniprotkb:P08559 intact:EBI-2511486|ensembl:ENSP00000341037|uniprotkb:Q8WXX2|uniprotkb:Q9UF86|uniprotkb:Q8NCN7|intact:EBI-11109494|uniprotkb:H0YJJ1|uniprotkb:Q86TU2|uniprotkb:B4DN18|uniprotkb:E7EUY8|uniprotkb:F8W9S4|uniprotkb:G3V2F8|uniprotkb:G3V5R0 intact:EBI-715747|uniprotkb:Q9NP12|uniprotkb:Q9UBJ8|uniprotkb:Q9UBU0|uniprotkb:Q9UNG4|uniprotkb:Q9UNG5|uniprotkb:Q5JPT8|uniprotkb:Q53H41|uniprotkb:B2R5P7|uniprotkb:B7Z3T7|uniprotkb:B7Z3X5|uniprotkb:A5YVE9|ensembl:ENSP00000394382 psi-mi:wdr20_human(display_long)|uniprotkb:WDR20(gene name)|psi-mi:WDR20(display_short)|uniprotkb:Protein DMR(gene name synonym) psi-mi:odpa_human(display_long)|uniprotkb:PDHE1-A type I(gene name synonym)|uniprotkb:PDHA1(gene name)|psi-mi:PDHA1(display_short)|uniprotkb:PHE1A(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515515|imex:IM-12079-99 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000140153(gene)|ensembl:ENST00000342702(transcript)|go:"GO:0005654"(nucleoplasm)|interpro:IPR001680(WD40 repeat)|interpro:IPR036322|mint:Q8TBZ3|rcsb pdb:5K19|rcsb pdb:5K1C|rcsb pdb:6JLQ|reactome:R-HSA-5689880|refseq:NP_001229343.1|refseq:NP_001229345.1|refseq:NP_001229346.1|refseq:NP_001229347.1|refseq:NP_653175.2|refseq:NP_851808.1|refseq:NP_851825.1|refseq:NP_001229344.1 refseq:NP_001166926.1|refseq:NP_001166927.1|refseq:NP_000275.1|refseq:NP_001166925.1|ensembl:ENSG00000131828(gene)|ensembl:ENST00000422285(transcript)|go:"GO:0004739"("pyruvate dehydrogenase (acetyl-transferring) activity")|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006086"(acetyl-CoA biosynthetic process from pyruvate)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0034604"("pyruvate dehydrogenase (NAD+) activity")|go:"GO:0045254"(pyruvate dehydrogenase complex)|go:"GO:0061732"(mitochondrial acetyl-CoA biosynthetic process from pyruvate)|interpro:IPR001017(Dehydrogenase, E1 component)|interpro:IPR017597("Pyruvate dehydrogenase (acetyl-transferring) E1 component, alpha subunit, subgroup y")|interpro:IPR029061|rcsb pdb:1NI4|rcsb pdb:2OZL|rcsb pdb:3EXE|rcsb pdb:3EXF|rcsb pdb:3EXG|rcsb pdb:3EXH|rcsb pdb:3EXI|rcsb pdb:6CER|rcsb pdb:6CFO|reactome:R-HSA-204174|reactome:R-HSA-389661|reactome:R-HSA-5362517|reactome:R-HSA-70268|dip:DIP-37652N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:2MfZps9YU8xQbWazkq2sIqXjHHg9606 rogid:p4PObFZ4cxJW6ICug+jhlgKlEYY9606 intact-crc:8EF7A3D1C62AD212|rigid:k+CJH1A1pcvvsGjo5ra4m2pF0Gs false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8TBZ3 uniprotkb:Q04323 intact:EBI-2511486|ensembl:ENSP00000341037|uniprotkb:Q8WXX2|uniprotkb:Q9UF86|uniprotkb:Q8NCN7|intact:EBI-11109494|uniprotkb:H0YJJ1|uniprotkb:Q86TU2|uniprotkb:B4DN18|uniprotkb:E7EUY8|uniprotkb:F8W9S4|uniprotkb:G3V2F8|uniprotkb:G3V5R0 intact:EBI-1058647|ensembl:ENSP00000303991|uniprotkb:Q9BV93|uniprotkb:Q9BVV5|intact:EBI-1993649 psi-mi:wdr20_human(display_long)|uniprotkb:WDR20(gene name)|psi-mi:WDR20(display_short)|uniprotkb:Protein DMR(gene name synonym) psi-mi:ubxn1_human(display_long)|uniprotkb:UBXN1(gene name)|psi-mi:UBXN1(display_short)|uniprotkb:SAKS1(gene name synonym)|uniprotkb:SAPK substrate protein 1(gene name synonym)|uniprotkb:UBA/UBX 33.3 kDa protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515515|imex:IM-12079-99 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000140153(gene)|ensembl:ENST00000342702(transcript)|go:"GO:0005654"(nucleoplasm)|interpro:IPR001680(WD40 repeat)|interpro:IPR036322|mint:Q8TBZ3|rcsb pdb:5K19|rcsb pdb:5K1C|rcsb pdb:6JLQ|reactome:R-HSA-5689880|refseq:NP_001229343.1|refseq:NP_001229345.1|refseq:NP_001229346.1|refseq:NP_001229347.1|refseq:NP_653175.2|refseq:NP_851808.1|refseq:NP_851825.1|refseq:NP_001229344.1 ensembl:ENSG00000162191(gene)|ensembl:ENST00000301935(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0030425"(dendrite)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034098"(VCP-NPL4-UFD1 AAA ATPase complex)|go:"GO:0036435"(K48-linked polyubiquitin modification-dependent protein binding)|refseq:NP_001273006.1|refseq:NP_001273007.1|refseq:NP_056937.2|go:"GO:0043025"(neuronal cell body)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0051117"(ATPase binding)|go:"GO:0071796"(K6-linked polyubiquitin modification-dependent protein binding)|go:"GO:1903094"(negative regulation of protein K48-linked deubiquitination)|go:"GO:1904293"(negative regulation of ERAD pathway)|go:"GO:1904855"(proteasome regulatory particle binding)|go:"GO:2000157"(negative regulation of ubiquitin-specific protease activity)|interpro:IPR001012(UBX)|interpro:IPR009060(UBA-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR029071|interpro:IPR041923|reactome:R-HSA-532668|reactome:R-HSA-5693565|go:"GO:0043130"(ubiquitin binding)|refseq:XP_005274090.1|refseq:XP_016873363.1|dip:DIP-29467N psi-mi:"MI:0469"(intact) - crc64:E4E0C8BBAC93F2BB figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:2MfZps9YU8xQbWazkq2sIqXjHHg9606 rogid:KdHMRM9FSd6VT6MvJTxzdjARlRw9606 intact-crc:8EF7A3D1C62AD212|rigid:k+CJH1A1pcvvsGjo5ra4m2pF0Gs false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8TBZ3 uniprotkb:O15160 intact:EBI-2511486|ensembl:ENSP00000341037|uniprotkb:Q8WXX2|uniprotkb:Q9UF86|uniprotkb:Q8NCN7|intact:EBI-11109494|uniprotkb:H0YJJ1|uniprotkb:Q86TU2|uniprotkb:B4DN18|uniprotkb:E7EUY8|uniprotkb:F8W9S4|uniprotkb:G3V2F8|uniprotkb:G3V5R0 intact:EBI-1055079|uniprotkb:O75395|uniprotkb:Q5JTE3|ensembl:ENSP00000496044 psi-mi:wdr20_human(display_long)|uniprotkb:WDR20(gene name)|psi-mi:WDR20(display_short)|uniprotkb:Protein DMR(gene name synonym) psi-mi:rpac1_human(display_long)|uniprotkb:DNA-directed RNA polymerases I and III 40 kDa polypeptide(gene name synonym)|uniprotkb:RPC40(gene name synonym)|uniprotkb:AC40(gene name synonym)|uniprotkb:RPA39(gene name synonym)|uniprotkb:POLR1C(gene name)|psi-mi:POLR1C(display_short)|uniprotkb:POLR1E(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515515|imex:IM-12079-99 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000140153(gene)|ensembl:ENST00000342702(transcript)|go:"GO:0005654"(nucleoplasm)|interpro:IPR001680(WD40 repeat)|interpro:IPR036322|mint:Q8TBZ3|rcsb pdb:5K19|rcsb pdb:5K1C|rcsb pdb:6JLQ|reactome:R-HSA-5689880|refseq:NP_001229343.1|refseq:NP_001229345.1|refseq:NP_001229346.1|refseq:NP_001229347.1|refseq:NP_653175.2|refseq:NP_851808.1|refseq:NP_851825.1|refseq:NP_001229344.1 refseq:NP_001305805.1|refseq:NP_976035.1|ensembl:ENSG00000171453(gene)|ensembl:ENST00000642195(transcript)|go:"GO:0001054"(RNA polymerase I activity)|go:"GO:0001056"(RNA polymerase III activity)|go:"GO:0003677"(DNA binding)|go:"GO:0003899"(DNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005666"(RNA polymerase III complex)|go:"GO:0005736"(RNA polymerase I complex)|go:"GO:0005829"(cytosol)|go:"GO:0006360"(transcription by RNA polymerase I)|go:"GO:0046983"(protein dimerization activity)|interpro:IPR001514(DNA-directed RNA polymerase, 30-40 kDa subunit, conserved site)|interpro:IPR011262(DNA-directed RNA polymerase, insert)|interpro:IPR011263(DNA-directed RNA polymerase, RpoA/D/Rpb3-type)|interpro:IPR033901|interpro:IPR036603|interpro:IPR036643|mint:O15160|rcsb pdb:7A6H|rcsb pdb:7AE1|rcsb pdb:7AE3|rcsb pdb:7AEA|rcsb pdb:7AST|rcsb pdb:7D58|rcsb pdb:7D59|rcsb pdb:7DN3|rcsb pdb:7DU2|reactome:R-HSA-1834949|reactome:R-HSA-427413|reactome:R-HSA-5250924|reactome:R-HSA-73762|reactome:R-HSA-73772|reactome:R-HSA-73780|reactome:R-HSA-73863|reactome:R-HSA-73980|reactome:R-HSA-749476|reactome:R-HSA-76061|reactome:R-HSA-76066|reactome:R-HSA-76071|dip:DIP-27587N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:2MfZps9YU8xQbWazkq2sIqXjHHg9606 rogid:xSIuJ9kjLRZ6Vc9EnLdvX/CBJKU9606 intact-crc:8EF7A3D1C62AD212|rigid:k+CJH1A1pcvvsGjo5ra4m2pF0Gs false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8TBZ3 uniprotkb:Q96CV9 intact:EBI-2511486|ensembl:ENSP00000341037|uniprotkb:Q8WXX2|uniprotkb:Q9UF86|uniprotkb:Q8NCN7|intact:EBI-11109494|uniprotkb:H0YJJ1|uniprotkb:Q86TU2|uniprotkb:B4DN18|uniprotkb:E7EUY8|uniprotkb:F8W9S4|uniprotkb:G3V2F8|uniprotkb:G3V5R0 intact:EBI-748974|uniprotkb:Q5T672|uniprotkb:Q5T673|uniprotkb:Q5T674|uniprotkb:Q5T675|uniprotkb:Q7LDL9|uniprotkb:Q8N562|uniprotkb:Q9UET9|uniprotkb:Q9UEV4|uniprotkb:Q9Y218|uniprotkb:B3KP00|uniprotkb:D3DRS4|uniprotkb:D3DRS8|ensembl:ENSP00000263036|ensembl:ENSP00000368021|ensembl:ENSP00000368022|ensembl:ENSP00000368032 psi-mi:wdr20_human(display_long)|uniprotkb:WDR20(gene name)|psi-mi:WDR20(display_short)|uniprotkb:Protein DMR(gene name synonym) psi-mi:optn_human(display_long)|uniprotkb:HYPL(gene name synonym)|uniprotkb:Optic neuropathy-inducing protein(gene name synonym)|uniprotkb:E3-14.7K-interacting protein(gene name synonym)|uniprotkb:FIP-2(gene name synonym)|uniprotkb:Huntingtin-interacting protein L(gene name synonym)|uniprotkb:Huntingtin yeast partner L(gene name synonym)|uniprotkb:NEMO-related protein(gene name synonym)|uniprotkb:Transcription factor IIIA-interacting protein(gene name synonym)|uniprotkb:OPTN(gene name)|psi-mi:OPTN(display_short)|uniprotkb:FIP2(gene name synonym)|uniprotkb:GLC1E(gene name synonym)|uniprotkb:NRP(gene name synonym)|uniprotkb:HIP7(gene name synonym)|uniprotkb:Huntingtin-interacting protein 7(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515515|imex:IM-12079-99 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000140153(gene)|ensembl:ENST00000342702(transcript)|go:"GO:0005654"(nucleoplasm)|interpro:IPR001680(WD40 repeat)|interpro:IPR036322|mint:Q8TBZ3|rcsb pdb:5K19|rcsb pdb:5K1C|rcsb pdb:6JLQ|reactome:R-HSA-5689880|refseq:NP_001229343.1|refseq:NP_001229345.1|refseq:NP_001229346.1|refseq:NP_001229347.1|refseq:NP_653175.2|refseq:NP_851808.1|refseq:NP_851825.1|refseq:NP_001229344.1 refseq:NP_001008212.1|refseq:NP_001008213.1|refseq:NP_001008214.1|refseq:NP_068815.2|ensembl:ENSG00000123240(gene)|ensembl:ENST00000263036(transcript)|ensembl:ENST00000378747(transcript)|ensembl:ENST00000378748(transcript)|ensembl:ENST00000378757(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001920"(negative regulation of receptor recycling)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005776"(autophagosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0007030"(Golgi organization)|go:"GO:0007165"(signal transduction)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008219"(cell death)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031267"(small GTPase binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045087"(innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0034067"(protein localization to Golgi apparatus)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0061734"(parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0090161"(Golgi ribbon formation)|go:"GO:1904417"(positive regulation of xenophagy)|interpro:IPR021063|interpro:IPR032419|interpro:IPR032939|interpro:IPR034735|mint:Q96CV9|rcsb pdb:2LO4|rcsb pdb:2LUE|rcsb pdb:3VTV|rcsb pdb:3VTW|rcsb pdb:5AAZ|rcsb pdb:5B83|rcsb pdb:5EOA|rcsb pdb:5EOF|rcsb pdb:7CZM|reactome:R-HSA-2565942|reactome:R-HSA-8854214|dip:DIP-42001N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:2MfZps9YU8xQbWazkq2sIqXjHHg9606 rogid:jcCTXDx1bJq3K5mgNUD73jeWeBU9606 intact-crc:8EF7A3D1C62AD212|rigid:k+CJH1A1pcvvsGjo5ra4m2pF0Gs false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8TBZ3 uniprotkb:Q969U6 intact:EBI-2511486|ensembl:ENSP00000341037|uniprotkb:Q8WXX2|uniprotkb:Q9UF86|uniprotkb:Q8NCN7|intact:EBI-11109494|uniprotkb:H0YJJ1|uniprotkb:Q86TU2|uniprotkb:B4DN18|uniprotkb:E7EUY8|uniprotkb:F8W9S4|uniprotkb:G3V2F8|uniprotkb:G3V5R0 intact:EBI-741068|ensembl:ENSP00000313034|uniprotkb:Q5SPZ8|uniprotkb:Q5SPZ9|uniprotkb:Q5SQ02|uniprotkb:Q5SQ03|uniprotkb:Q5SQ04|uniprotkb:Q8WY79|uniprotkb:Q96GJ6|uniprotkb:Q9BSU8|uniprotkb:Q9H6A8|uniprotkb:Q9HBQ6|uniprotkb:Q9NSZ3|uniprotkb:B2RDZ6|uniprotkb:Q59ET5|uniprotkb:Q5SQ00 psi-mi:wdr20_human(display_long)|uniprotkb:WDR20(gene name)|psi-mi:WDR20(display_short)|uniprotkb:Protein DMR(gene name synonym) psi-mi:fbxw5_human(display_long)|uniprotkb:F-box and WD-40 domain-containing protein 5(gene name synonym)|uniprotkb:FBXW5(gene name)|psi-mi:FBXW5(display_short)|uniprotkb:FBW5(gene name synonym)|uniprotkb:PP3971(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515515|imex:IM-12079-99 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000140153(gene)|ensembl:ENST00000342702(transcript)|go:"GO:0005654"(nucleoplasm)|interpro:IPR001680(WD40 repeat)|interpro:IPR036322|mint:Q8TBZ3|rcsb pdb:5K19|rcsb pdb:5K1C|rcsb pdb:6JLQ|reactome:R-HSA-5689880|refseq:NP_001229343.1|refseq:NP_001229345.1|refseq:NP_001229346.1|refseq:NP_001229347.1|refseq:NP_653175.2|refseq:NP_851808.1|refseq:NP_851825.1|refseq:NP_001229344.1 ensembl:ENSG00000159069(gene)|ensembl:ENST00000325285(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0010824"(regulation of centrosome duplication)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0080008"(Cul4-RING E3 ubiquitin ligase complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR036047|interpro:IPR036322|interpro:IPR042508|mint:Q969U6|reactome:R-HSA-390471|reactome:R-HSA-8951664|reactome:R-HSA-983168|refseq:NP_061871.1|dip:DIP-37971N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:2MfZps9YU8xQbWazkq2sIqXjHHg9606 rogid:5K7xqxsvQuvEqWljgZXi/I+aWxE9606 intact-crc:8EF7A3D1C62AD212|rigid:k+CJH1A1pcvvsGjo5ra4m2pF0Gs false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8TBZ3 uniprotkb:P31946 intact:EBI-2511486|ensembl:ENSP00000341037|uniprotkb:Q8WXX2|uniprotkb:Q9UF86|uniprotkb:Q8NCN7|intact:EBI-11109494|uniprotkb:H0YJJ1|uniprotkb:Q86TU2|uniprotkb:B4DN18|uniprotkb:E7EUY8|uniprotkb:F8W9S4|uniprotkb:G3V2F8|uniprotkb:G3V5R0 intact:EBI-359815|uniprotkb:A8K9K2|uniprotkb:E1P616|ensembl:ENSP00000300161|ensembl:ENSP00000361930 psi-mi:wdr20_human(display_long)|uniprotkb:WDR20(gene name)|psi-mi:WDR20(display_short)|uniprotkb:Protein DMR(gene name synonym) psi-mi:1433b_human(display_long)|uniprotkb:YWHAB(gene name)|psi-mi:YWHAB(display_short)|uniprotkb:Protein kinase C inhibitor protein 1(gene name synonym)|uniprotkb:Protein 1054(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515515|imex:IM-12079-99 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000140153(gene)|ensembl:ENST00000342702(transcript)|go:"GO:0005654"(nucleoplasm)|interpro:IPR001680(WD40 repeat)|interpro:IPR036322|mint:Q8TBZ3|rcsb pdb:5K19|rcsb pdb:5K1C|rcsb pdb:6JLQ|reactome:R-HSA-5689880|refseq:NP_001229343.1|refseq:NP_001229345.1|refseq:NP_001229346.1|refseq:NP_001229347.1|refseq:NP_653175.2|refseq:NP_851808.1|refseq:NP_851825.1|refseq:NP_001229344.1 refseq:NP_003395.1|refseq:NP_647539.1|go:"GO:0050815"(phosphoserine residue binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051220"(cytoplasmic sequestering of protein)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:P31946|rcsb pdb:2BQ0|rcsb pdb:2C23|rcsb pdb:4DNK|rcsb pdb:5N10|rcsb pdb:6A5Q|rcsb pdb:6BYK|rcsb pdb:6GN0|rcsb pdb:6GN8|rcsb pdb:6GNJ|rcsb pdb:6GNK|rcsb pdb:6GNN|rcsb pdb:6HEP|reactome:R-HSA-111447|reactome:R-HSA-1445148|reactome:R-HSA-165159|reactome:R-HSA-166208|reactome:R-HSA-170968|reactome:R-HSA-170984|reactome:R-HSA-2028269|reactome:R-HSA-392517|reactome:R-HSA-450385|reactome:R-HSA-450513|reactome:R-HSA-5625740|reactome:R-HSA-5628897|reactome:R-HSA-5673000|reactome:R-HSA-5674135|reactome:R-HSA-5675221|reactome:R-HSA-6802946|reactome:R-HSA-6802948|reactome:R-HSA-6802952|reactome:R-HSA-6802955|reactome:R-HSA-75035|reactome:R-HSA-9614399|reactome:R-HSA-9649948|reactome:R-HSA-9656223|reactome:R-HSA-9660537|ensembl:ENSG00000166913(gene)|ensembl:ENST00000353703(transcript)|ensembl:ENST00000372839(transcript)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005774"(vacuolar membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0006605"(protein targeting)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0016020"(membrane)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0035308"(negative regulation of protein dephosphorylation)|go:"GO:0042470"(melanosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|refseq:XP_016883528.1|dip:DIP-743N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:2MfZps9YU8xQbWazkq2sIqXjHHg9606 rogid:rp43CodPzsPadWEPtbnpKFAVIIU9606 intact-crc:8EF7A3D1C62AD212|rigid:k+CJH1A1pcvvsGjo5ra4m2pF0Gs false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8TBZ3 uniprotkb:Q8TAF3 intact:EBI-2511486|ensembl:ENSP00000341037|uniprotkb:Q8WXX2|uniprotkb:Q9UF86|uniprotkb:Q8NCN7|intact:EBI-11109494|uniprotkb:H0YJJ1|uniprotkb:Q86TU2|uniprotkb:B4DN18|uniprotkb:E7EUY8|uniprotkb:F8W9S4|uniprotkb:G3V2F8|uniprotkb:G3V5R0 intact:EBI-1045469|uniprotkb:Q63HJ2|uniprotkb:Q658Y1|uniprotkb:Q8N3Z1|uniprotkb:Q9NSK8|uniprotkb:Q9P279|uniprotkb:B4DM86|uniprotkb:B4DQI2|uniprotkb:B4DY84|ensembl:ENSP00000307491 psi-mi:wdr20_human(display_long)|uniprotkb:WDR20(gene name)|psi-mi:WDR20(display_short)|uniprotkb:Protein DMR(gene name synonym) psi-mi:wdr48_human(display_long)|uniprotkb:WD repeat endosomal protein(gene name synonym)|uniprotkb:p80(gene name synonym)|uniprotkb:WDR48(gene name)|psi-mi:WDR48(display_short)|uniprotkb:KIAA1449(gene name synonym)|uniprotkb:UAF1(gene name synonym)|uniprotkb:USP1-associated factor 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515515|imex:IM-12079-99 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000140153(gene)|ensembl:ENST00000342702(transcript)|go:"GO:0005654"(nucleoplasm)|interpro:IPR001680(WD40 repeat)|interpro:IPR036322|mint:Q8TBZ3|rcsb pdb:5K19|rcsb pdb:5K1C|rcsb pdb:6JLQ|reactome:R-HSA-5689880|refseq:NP_001229343.1|refseq:NP_001229345.1|refseq:NP_001229346.1|refseq:NP_001229347.1|refseq:NP_653175.2|refseq:NP_851808.1|refseq:NP_851825.1|refseq:NP_001229344.1 refseq:NP_065890.1|ensembl:ENSG00000114742(gene)|ensembl:ENST00000302313(transcript)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0003677"(DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043588"(skin development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0072520"(seminiferous tubule development)|go:"GO:1902525"(regulation of protein monoubiquitination)|go:"GO:1903003"(positive regulation of protein deubiquitination)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR021772|interpro:IPR036322|mint:Q8TAF3|rcsb pdb:5CVL|rcsb pdb:5CVN|rcsb pdb:5CVO|rcsb pdb:5K1A|rcsb pdb:5K1B|rcsb pdb:5K1C|rcsb pdb:5L8E|rcsb pdb:5L8W|rcsb pdb:6JLQ|rcsb pdb:7AY0|rcsb pdb:7AY1|rcsb pdb:7AY2|reactome:R-HSA-110314|reactome:R-HSA-5689880|reactome:R-HSA-6783310|reactome:R-HSA-9673766|refseq:NP_001290331.1|refseq:NP_001290332.1|refseq:NP_001333156.1|refseq:NP_001333157.1|dip:DIP-50841N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:2MfZps9YU8xQbWazkq2sIqXjHHg9606 rogid:S8ihl3jxEEyMS46AM2ynXSFfCU49606 intact-crc:8EF7A3D1C62AD212|rigid:k+CJH1A1pcvvsGjo5ra4m2pF0Gs false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8TBZ3 uniprotkb:Q04917 intact:EBI-2511486|ensembl:ENSP00000341037|uniprotkb:Q8WXX2|uniprotkb:Q9UF86|uniprotkb:Q8NCN7|intact:EBI-11109494|uniprotkb:H0YJJ1|uniprotkb:Q86TU2|uniprotkb:B4DN18|uniprotkb:E7EUY8|uniprotkb:F8W9S4|uniprotkb:G3V2F8|uniprotkb:G3V5R0 intact:EBI-306940|ensembl:ENSP00000248975|intact:EBI-11759595 psi-mi:wdr20_human(display_long)|uniprotkb:WDR20(gene name)|psi-mi:WDR20(display_short)|uniprotkb:Protein DMR(gene name synonym) psi-mi:1433f_human(display_long)|uniprotkb:YWHAH(gene name)|psi-mi:YWHAH(display_short)|uniprotkb:YWHA1(gene name synonym)|uniprotkb:Protein AS1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515515|imex:IM-12079-99 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000140153(gene)|ensembl:ENST00000342702(transcript)|go:"GO:0005654"(nucleoplasm)|interpro:IPR001680(WD40 repeat)|interpro:IPR036322|mint:Q8TBZ3|rcsb pdb:5K19|rcsb pdb:5K1C|rcsb pdb:6JLQ|reactome:R-HSA-5689880|refseq:NP_001229343.1|refseq:NP_001229345.1|refseq:NP_001229346.1|refseq:NP_001229347.1|refseq:NP_653175.2|refseq:NP_851808.1|refseq:NP_851825.1|refseq:NP_001229344.1 go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0050774"(negative regulation of dendrite morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0086010"(membrane depolarization during action potential)|go:"GO:2000649"(regulation of sodium ion transmembrane transporter activity)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:Q04917|rcsb pdb:2C63|rcsb pdb:2C74|reactome:R-HSA-111447|reactome:R-HSA-1445148|reactome:R-HSA-5625740|reactome:R-HSA-5628897|reactome:R-HSA-75035|ensembl:ENSG00000128245(gene)|ensembl:ENST00000248975(transcript)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0003779"(actin binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006713"(glucocorticoid catabolic process)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0014704"(intercalated disc)|go:"GO:0017080"(sodium channel regulator activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021762"(substantia nigra development)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042921"(glucocorticoid receptor signaling pathway)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|refseq:NP_003396.1|dip:DIP-27566N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2018/04/06 rogid:2MfZps9YU8xQbWazkq2sIqXjHHg9606 rogid:VhFYPSsW3IRC388FTlmwwN37HnU9606 intact-crc:8EF7A3D1C62AD212|rigid:k+CJH1A1pcvvsGjo5ra4m2pF0Gs false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8TAF3 uniprotkb:P36954 intact:EBI-1045469|uniprotkb:Q63HJ2|uniprotkb:Q658Y1|uniprotkb:Q8N3Z1|uniprotkb:Q9NSK8|uniprotkb:Q9P279|uniprotkb:B4DM86|uniprotkb:B4DQI2|uniprotkb:B4DY84|ensembl:ENSP00000307491 intact:EBI-395202|uniprotkb:Q6NW05|uniprotkb:B2R5J2|ensembl:ENSP00000221859 psi-mi:wdr48_human(display_long)|uniprotkb:WD repeat endosomal protein(gene name synonym)|uniprotkb:p80(gene name synonym)|uniprotkb:WDR48(gene name)|psi-mi:WDR48(display_short)|uniprotkb:KIAA1449(gene name synonym)|uniprotkb:UAF1(gene name synonym)|uniprotkb:USP1-associated factor 1(gene name synonym) psi-mi:rpb9_human(display_long)|uniprotkb:POLR2I(gene name)|psi-mi:POLR2I(display_short)|uniprotkb:DNA-directed RNA polymerase II subunit I(gene name synonym)|uniprotkb:RNA polymerase II 14.5 kDa subunit(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515634|imex:IM-12079-49 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065890.1|ensembl:ENSG00000114742(gene)|ensembl:ENST00000302313(transcript)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0003677"(DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043588"(skin development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0072520"(seminiferous tubule development)|go:"GO:1902525"(regulation of protein monoubiquitination)|go:"GO:1903003"(positive regulation of protein deubiquitination)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR021772|interpro:IPR036322|mint:Q8TAF3|rcsb pdb:5CVL|rcsb pdb:5CVN|rcsb pdb:5CVO|rcsb pdb:5K1A|rcsb pdb:5K1B|rcsb pdb:5K1C|rcsb pdb:5L8E|rcsb pdb:5L8W|rcsb pdb:6JLQ|rcsb pdb:7AY0|rcsb pdb:7AY1|rcsb pdb:7AY2|reactome:R-HSA-110314|reactome:R-HSA-5689880|reactome:R-HSA-6783310|reactome:R-HSA-9673766|refseq:NP_001290331.1|refseq:NP_001290332.1|refseq:NP_001333156.1|refseq:NP_001333157.1|dip:DIP-50841N refseq:NP_006224.1|ensembl:ENSG00000105258(gene)|ensembl:ENST00000221859(transcript)|go:"GO:0001193"(maintenance of transcriptional fidelity during DNA-templated transcription elongation from RNA polymerase II promoter)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0003899"(DNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005665"(RNA polymerase II, core complex)|go:"GO:0005730"(nucleolus)|go:"GO:0006283"(transcription-coupled nucleotide-excision repair)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0006379"(mRNA cleavage)|go:"GO:0008270"(zinc ion binding)|interpro:IPR001222(Zinc finger, TFIIS-type)|interpro:IPR001529(DNA-directed RNA polymerase, M/15 kDa subunit)|interpro:IPR012164(DNA-directed RNA polymerase, subunit C11/M/9)|interpro:IPR019761|interpro:IPR034012|mint:P36954|rcsb pdb:5IY6|rcsb pdb:5IY7|rcsb pdb:5IY8|rcsb pdb:5IY9|rcsb pdb:5IYA|rcsb pdb:5IYB|rcsb pdb:5IYC|rcsb pdb:5IYD|rcsb pdb:6DRD|rcsb pdb:6O9L|rcsb pdb:6XRE|rcsb pdb:7LBM|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167160|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167242|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-168325|reactome:R-HSA-203927|reactome:R-HSA-5578749|reactome:R-HSA-5601884|reactome:R-HSA-5617472|reactome:R-HSA-674695|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6796648|reactome:R-HSA-6803529|reactome:R-HSA-6807505|reactome:R-HSA-72086|reactome:R-HSA-72163|reactome:R-HSA-72165|reactome:R-HSA-72203|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-75953|reactome:R-HSA-75955|reactome:R-HSA-76042|reactome:R-HSA-77075|reactome:R-HSA-8851708|reactome:R-HSA-9018519|reactome:R-HSA-9670095|dip:DIP-32917N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/05/28 rogid:S8ihl3jxEEyMS46AM2ynXSFfCU49606 rogid:YZUW2UDzj1RhCC46iaX1LvYayNA9606 intact-crc:FEA84E4597BF2CAC|rigid:5VpwlpQqzlunHNK7tN6q4Wo+lkI false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8TAF3 uniprotkb:Q8N680 intact:EBI-1045469|uniprotkb:Q63HJ2|uniprotkb:Q658Y1|uniprotkb:Q8N3Z1|uniprotkb:Q9NSK8|uniprotkb:Q9P279|uniprotkb:B4DM86|uniprotkb:B4DQI2|uniprotkb:B4DY84|ensembl:ENSP00000307491 intact:EBI-2515601|ensembl:ENSP00000323183|uniprotkb:A8K7C7|uniprotkb:Q9P245|uniprotkb:Q5SZ81 psi-mi:wdr48_human(display_long)|uniprotkb:WD repeat endosomal protein(gene name synonym)|uniprotkb:p80(gene name synonym)|uniprotkb:WDR48(gene name)|psi-mi:WDR48(display_short)|uniprotkb:KIAA1449(gene name synonym)|uniprotkb:UAF1(gene name synonym)|uniprotkb:USP1-associated factor 1(gene name synonym) psi-mi:zbtb2_human(display_long)|uniprotkb:ZBTB2(gene name)|psi-mi:ZBTB2(display_short)|uniprotkb:KIAA1483(gene name synonym)|uniprotkb:ZNF437(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515634|imex:IM-12079-49 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065890.1|ensembl:ENSG00000114742(gene)|ensembl:ENST00000302313(transcript)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0003677"(DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043588"(skin development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0072520"(seminiferous tubule development)|go:"GO:1902525"(regulation of protein monoubiquitination)|go:"GO:1903003"(positive regulation of protein deubiquitination)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR021772|interpro:IPR036322|mint:Q8TAF3|rcsb pdb:5CVL|rcsb pdb:5CVN|rcsb pdb:5CVO|rcsb pdb:5K1A|rcsb pdb:5K1B|rcsb pdb:5K1C|rcsb pdb:5L8E|rcsb pdb:5L8W|rcsb pdb:6JLQ|rcsb pdb:7AY0|rcsb pdb:7AY1|rcsb pdb:7AY2|reactome:R-HSA-110314|reactome:R-HSA-5689880|reactome:R-HSA-6783310|reactome:R-HSA-9673766|refseq:NP_001290331.1|refseq:NP_001290332.1|refseq:NP_001333156.1|refseq:NP_001333157.1|dip:DIP-50841N ensembl:ENSG00000181472(gene)|ensembl:ENST00000325144(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|interpro:IPR011333(BTB/POZ fold)|refseq:XP_011534306.1|refseq:NP_065912.1|refseq:XP_005267133.1|dip:DIP-53681N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/05/28 rogid:S8ihl3jxEEyMS46AM2ynXSFfCU49606 rogid:J8GO/U3lUReim2GO9Xq7D3dRZBQ9606 intact-crc:FEA84E4597BF2CAC|rigid:5VpwlpQqzlunHNK7tN6q4Wo+lkI false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8TAF3 uniprotkb:O75592 intact:EBI-1045469|uniprotkb:Q63HJ2|uniprotkb:Q658Y1|uniprotkb:Q8N3Z1|uniprotkb:Q9NSK8|uniprotkb:Q9P279|uniprotkb:B4DM86|uniprotkb:B4DQI2|uniprotkb:B4DY84|ensembl:ENSP00000307491 intact:EBI-1043774|uniprotkb:Q5JSX8|uniprotkb:Q5VZN6|uniprotkb:Q6PIB6|uniprotkb:Q9UQ11|uniprotkb:Q9Y6E4|uniprotkb:A6NJC6|ensembl:ENSP00000444596 psi-mi:wdr48_human(display_long)|uniprotkb:WD repeat endosomal protein(gene name synonym)|uniprotkb:p80(gene name synonym)|uniprotkb:WDR48(gene name)|psi-mi:WDR48(display_short)|uniprotkb:KIAA1449(gene name synonym)|uniprotkb:UAF1(gene name synonym)|uniprotkb:USP1-associated factor 1(gene name synonym) psi-mi:mycb2_human(display_long)|uniprotkb:MYCBP2(gene name)|psi-mi:MYCBP2(display_short)|uniprotkb:KIAA0916(gene name synonym)|uniprotkb:PAM(gene name synonym)|uniprotkb:Myc-binding protein 2(gene name synonym)|uniprotkb:Protein associated with Myc(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515634|imex:IM-12079-49 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065890.1|ensembl:ENSG00000114742(gene)|ensembl:ENST00000302313(transcript)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0003677"(DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043588"(skin development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0072520"(seminiferous tubule development)|go:"GO:1902525"(regulation of protein monoubiquitination)|go:"GO:1903003"(positive regulation of protein deubiquitination)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR021772|interpro:IPR036322|mint:Q8TAF3|rcsb pdb:5CVL|rcsb pdb:5CVN|rcsb pdb:5CVO|rcsb pdb:5K1A|rcsb pdb:5K1B|rcsb pdb:5K1C|rcsb pdb:5L8E|rcsb pdb:5L8W|rcsb pdb:6JLQ|rcsb pdb:7AY0|rcsb pdb:7AY1|rcsb pdb:7AY2|reactome:R-HSA-110314|reactome:R-HSA-5689880|reactome:R-HSA-6783310|reactome:R-HSA-9673766|refseq:NP_001290331.1|refseq:NP_001290332.1|refseq:NP_001333156.1|refseq:NP_001333157.1|dip:DIP-50841N refseq:NP_055872.4|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1902667"(regulation of axon guidance)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003646(Bacterial SH3-like region)|interpro:IPR004939(Anaphase-promoting complex, subunit 10)|interpro:IPR008979(Galactose-binding like)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR012983(PHR)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017868|interpro:IPR038648|mint:O75592|rcsb pdb:5O6C|rcsb pdb:6T7F|ensembl:ENSG00000005810(gene)|ensembl:ENST00000544440(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021785"(branchiomotor neuron axon guidance)|go:"GO:0021952"(central nervous system projection neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032880"(regulation of protein localization)|dip:DIP-28142N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/05/28 rogid:S8ihl3jxEEyMS46AM2ynXSFfCU49606 rogid:AR3FR/zd48HkVinEfdT17ItGkbU9606 intact-crc:FEA84E4597BF2CAC|rigid:5VpwlpQqzlunHNK7tN6q4Wo+lkI false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8TAF3 uniprotkb:Q32P28 intact:EBI-1045469|uniprotkb:Q63HJ2|uniprotkb:Q658Y1|uniprotkb:Q8N3Z1|uniprotkb:Q9NSK8|uniprotkb:Q9P279|uniprotkb:B4DM86|uniprotkb:B4DQI2|uniprotkb:B4DY84|ensembl:ENSP00000307491 intact:EBI-396328|uniprotkb:Q96SK8|uniprotkb:Q7KZR4|uniprotkb:Q96BR8|uniprotkb:Q96SL5|uniprotkb:Q96SN3|uniprotkb:Q9H6K3|uniprotkb:Q9HC86|uniprotkb:Q9HC87|intact:EBI-2555416|ensembl:ENSP00000296388 psi-mi:wdr48_human(display_long)|uniprotkb:WD repeat endosomal protein(gene name synonym)|uniprotkb:p80(gene name synonym)|uniprotkb:WDR48(gene name)|psi-mi:WDR48(display_short)|uniprotkb:KIAA1449(gene name synonym)|uniprotkb:UAF1(gene name synonym)|uniprotkb:USP1-associated factor 1(gene name synonym) psi-mi:p3h1_human(display_long)|uniprotkb:P3H1(gene name)|psi-mi:P3H1(display_short)|uniprotkb:GROS1(gene name synonym)|uniprotkb:Growth suppressor 1(gene name synonym)|uniprotkb:LEPRE1(gene name synonym)|uniprotkb:Leucine- and proline-enriched proteoglycan 1(gene name synonym)|uniprotkb:PSEC0109(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515634|imex:IM-12079-49 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065890.1|ensembl:ENSG00000114742(gene)|ensembl:ENST00000302313(transcript)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0003677"(DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043588"(skin development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0072520"(seminiferous tubule development)|go:"GO:1902525"(regulation of protein monoubiquitination)|go:"GO:1903003"(positive regulation of protein deubiquitination)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR021772|interpro:IPR036322|mint:Q8TAF3|rcsb pdb:5CVL|rcsb pdb:5CVN|rcsb pdb:5CVO|rcsb pdb:5K1A|rcsb pdb:5K1B|rcsb pdb:5K1C|rcsb pdb:5L8E|rcsb pdb:5L8W|rcsb pdb:6JLQ|rcsb pdb:7AY0|rcsb pdb:7AY1|rcsb pdb:7AY2|reactome:R-HSA-110314|reactome:R-HSA-5689880|reactome:R-HSA-6783310|reactome:R-HSA-9673766|refseq:NP_001290331.1|refseq:NP_001290332.1|refseq:NP_001333156.1|refseq:NP_001333157.1|dip:DIP-50841N refseq:NP_001139761.1|refseq:NP_001230175.1|refseq:NP_071751.3|ensembl:ENSG00000117385(gene)|ensembl:ENST00000296388(transcript)|go:"GO:0005506"(iron ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0006457"(protein folding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016020"(membrane)|go:"GO:0018126"(protein hydroxylation)|go:"GO:0019797"(procollagen-proline 3-dioxygenase activity)|go:"GO:0031418"(L-ascorbic acid binding)|go:"GO:0032963"(collagen metabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0050708"(regulation of protein secretion)|go:"GO:0050821"(protein stabilization)|go:"GO:0060348"(bone development)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0070062"(extracellular exosome)|go:"GO:1901874"(negative regulation of post-translational protein modification)|interpro:IPR005123("2OG-Fe(II) oxygenase")|interpro:IPR006620(Prolyl 4-hydroxylase, alpha subunit)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR039575|interpro:IPR039837|mint:Q32P28|reactome:R-HSA-1650814 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/05/28 rogid:S8ihl3jxEEyMS46AM2ynXSFfCU49606 rogid:L3euuYyawz69NXv4u6baW/ceVdU9606 intact-crc:FEA84E4597BF2CAC|rigid:5VpwlpQqzlunHNK7tN6q4Wo+lkI false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8TAF3 uniprotkb:Q96HR8 intact:EBI-1045469|uniprotkb:Q63HJ2|uniprotkb:Q658Y1|uniprotkb:Q8N3Z1|uniprotkb:Q9NSK8|uniprotkb:Q9P279|uniprotkb:B4DM86|uniprotkb:B4DQI2|uniprotkb:B4DY84|ensembl:ENSP00000307491 intact:EBI-2515597|ensembl:ENSP00000274054|uniprotkb:D3DP28|uniprotkb:E9PAZ2 psi-mi:wdr48_human(display_long)|uniprotkb:WD repeat endosomal protein(gene name synonym)|uniprotkb:p80(gene name synonym)|uniprotkb:WDR48(gene name)|psi-mi:WDR48(display_short)|uniprotkb:KIAA1449(gene name synonym)|uniprotkb:UAF1(gene name synonym)|uniprotkb:USP1-associated factor 1(gene name synonym) psi-mi:naf1_human(display_long)|uniprotkb:NAF1(gene name)|psi-mi:NAF1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515634|imex:IM-12079-49 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065890.1|ensembl:ENSG00000114742(gene)|ensembl:ENST00000302313(transcript)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0003677"(DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043588"(skin development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0072520"(seminiferous tubule development)|go:"GO:1902525"(regulation of protein monoubiquitination)|go:"GO:1903003"(positive regulation of protein deubiquitination)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR021772|interpro:IPR036322|mint:Q8TAF3|rcsb pdb:5CVL|rcsb pdb:5CVN|rcsb pdb:5CVO|rcsb pdb:5K1A|rcsb pdb:5K1B|rcsb pdb:5K1C|rcsb pdb:5L8E|rcsb pdb:5L8W|rcsb pdb:6JLQ|rcsb pdb:7AY0|rcsb pdb:7AY1|rcsb pdb:7AY2|reactome:R-HSA-110314|reactome:R-HSA-5689880|reactome:R-HSA-6783310|reactome:R-HSA-9673766|refseq:NP_001290331.1|refseq:NP_001290332.1|refseq:NP_001333156.1|refseq:NP_001333157.1|dip:DIP-50841N ensembl:ENSG00000145414(gene)|ensembl:ENST00000274054(transcript)|go:"GO:0000454"(snoRNA guided rRNA pseudouridine synthesis)|go:"GO:0000493"(box H/ACA snoRNP assembly)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005732"("sno(s)RNA-containing ribonucleoprotein complex")|go:"GO:0005737"(cytoplasm)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0042254"(ribosome biogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043489"(RNA stabilization)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0070034"(telomerase RNA binding)|go:"GO:0090669"(telomerase RNA stabilization)|go:"GO:1904358"(positive regulation of telomere maintenance via telomere lengthening)|go:"GO:1904874"(positive regulation of telomerase RNA localization to Cajal body)|go:"GO:1905323"(telomerase holoenzyme complex assembly)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)|interpro:IPR038664|interpro:IPR040309|mint:Q96HR8|rcsb pdb:2EQN|interpro:IPR007504(Gar1 protein RNA-binding region)|refseq:XP_011530712.1|refseq:NP_001122403.1|refseq:NP_612395.2 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/05/28 rogid:S8ihl3jxEEyMS46AM2ynXSFfCU49606 rogid:RN78Bx9nJvfGDvaezT/U4TUf2KY9606 intact-crc:FEA84E4597BF2CAC|rigid:5VpwlpQqzlunHNK7tN6q4Wo+lkI false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8TAF3 uniprotkb:Q7Z309 intact:EBI-1045469|uniprotkb:Q63HJ2|uniprotkb:Q658Y1|uniprotkb:Q8N3Z1|uniprotkb:Q9NSK8|uniprotkb:Q9P279|uniprotkb:B4DM86|uniprotkb:B4DQI2|uniprotkb:B4DY84|ensembl:ENSP00000307491 intact:EBI-2515087|uniprotkb:A8K902|uniprotkb:Q6ZV64|uniprotkb:Q8TB75|uniprotkb:Q6PIM2|uniprotkb:Q6ZVE4|uniprotkb:Q6ZU47|ensembl:ENSP00000359826 psi-mi:wdr48_human(display_long)|uniprotkb:WD repeat endosomal protein(gene name synonym)|uniprotkb:p80(gene name synonym)|uniprotkb:WDR48(gene name)|psi-mi:WDR48(display_short)|uniprotkb:KIAA1449(gene name synonym)|uniprotkb:UAF1(gene name synonym)|uniprotkb:USP1-associated factor 1(gene name synonym) psi-mi:pbir2_human(display_long)|uniprotkb:PABIR2(gene name)|psi-mi:PABIR2(display_short)|uniprotkb:FAM122B(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515634|imex:IM-12079-49 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065890.1|ensembl:ENSG00000114742(gene)|ensembl:ENST00000302313(transcript)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0003677"(DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043588"(skin development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0072520"(seminiferous tubule development)|go:"GO:1902525"(regulation of protein monoubiquitination)|go:"GO:1903003"(positive regulation of protein deubiquitination)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR021772|interpro:IPR036322|mint:Q8TAF3|rcsb pdb:5CVL|rcsb pdb:5CVN|rcsb pdb:5CVO|rcsb pdb:5K1A|rcsb pdb:5K1B|rcsb pdb:5K1C|rcsb pdb:5L8E|rcsb pdb:5L8W|rcsb pdb:6JLQ|rcsb pdb:7AY0|rcsb pdb:7AY1|rcsb pdb:7AY2|reactome:R-HSA-110314|reactome:R-HSA-5689880|reactome:R-HSA-6783310|reactome:R-HSA-9673766|refseq:NP_001290331.1|refseq:NP_001290332.1|refseq:NP_001333156.1|refseq:NP_001333157.1|dip:DIP-50841N refseq:NP_001160071.1|refseq:NP_001160072.1|refseq:NP_001164227.1|refseq:NP_001164228.1|refseq:NP_660327.2|ensembl:ENSG00000156504(gene)|ensembl:ENST00000370790(transcript)|go:"GO:0004865"(protein serine/threonine phosphatase inhibitor activity)|interpro:IPR026716|refseq:XP_011529595.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/05/28 rogid:S8ihl3jxEEyMS46AM2ynXSFfCU49606 rogid:o/CcZrpwlteNE7GV7agrsdQRe1c9606 intact-crc:FEA84E4597BF2CAC|rigid:5VpwlpQqzlunHNK7tN6q4Wo+lkI false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8TAF3 uniprotkb:O00193 intact:EBI-1045469|uniprotkb:Q63HJ2|uniprotkb:Q658Y1|uniprotkb:Q8N3Z1|uniprotkb:Q9NSK8|uniprotkb:Q9P279|uniprotkb:B4DM86|uniprotkb:B4DQI2|uniprotkb:B4DY84|ensembl:ENSP00000307491 intact:EBI-727094|uniprotkb:B2RD28|ensembl:ENSP00000228136 psi-mi:wdr48_human(display_long)|uniprotkb:WD repeat endosomal protein(gene name synonym)|uniprotkb:p80(gene name synonym)|uniprotkb:WDR48(gene name)|psi-mi:WDR48(display_short)|uniprotkb:KIAA1449(gene name synonym)|uniprotkb:UAF1(gene name synonym)|uniprotkb:USP1-associated factor 1(gene name synonym) psi-mi:smap_human(display_long)|uniprotkb:SMAP(gene name)|psi-mi:SMAP(display_short)|uniprotkb:C11orf58(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515634|imex:IM-12079-49 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065890.1|ensembl:ENSG00000114742(gene)|ensembl:ENST00000302313(transcript)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0003677"(DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043588"(skin development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0072520"(seminiferous tubule development)|go:"GO:1902525"(regulation of protein monoubiquitination)|go:"GO:1903003"(positive regulation of protein deubiquitination)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR021772|interpro:IPR036322|mint:Q8TAF3|rcsb pdb:5CVL|rcsb pdb:5CVN|rcsb pdb:5CVO|rcsb pdb:5K1A|rcsb pdb:5K1B|rcsb pdb:5K1C|rcsb pdb:5L8E|rcsb pdb:5L8W|rcsb pdb:6JLQ|rcsb pdb:7AY0|rcsb pdb:7AY1|rcsb pdb:7AY2|reactome:R-HSA-110314|reactome:R-HSA-5689880|reactome:R-HSA-6783310|reactome:R-HSA-9673766|refseq:NP_001290331.1|refseq:NP_001290332.1|refseq:NP_001333156.1|refseq:NP_001333157.1|dip:DIP-50841N refseq:NP_055082.1|ensembl:ENSG00000110696(gene)|ensembl:ENST00000228136(transcript)|interpro:IPR026714|interpro:IPR028124 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/05/28 rogid:S8ihl3jxEEyMS46AM2ynXSFfCU49606 rogid:QS9xLHC7bRYRxDvg37iPVulqwLg9606 intact-crc:FEA84E4597BF2CAC|rigid:5VpwlpQqzlunHNK7tN6q4Wo+lkI false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8TAF3 uniprotkb:Q15831 intact:EBI-1045469|uniprotkb:Q63HJ2|uniprotkb:Q658Y1|uniprotkb:Q8N3Z1|uniprotkb:Q9NSK8|uniprotkb:Q9P279|uniprotkb:B4DM86|uniprotkb:B4DQI2|uniprotkb:B4DY84|ensembl:ENSP00000307491 intact:EBI-306838|ensembl:ENSP00000324856|uniprotkb:E7EW76|uniprotkb:B2RBX7 psi-mi:wdr48_human(display_long)|uniprotkb:WD repeat endosomal protein(gene name synonym)|uniprotkb:p80(gene name synonym)|uniprotkb:WDR48(gene name)|psi-mi:WDR48(display_short)|uniprotkb:KIAA1449(gene name synonym)|uniprotkb:UAF1(gene name synonym)|uniprotkb:USP1-associated factor 1(gene name synonym) psi-mi:stk11_human(display_long)|uniprotkb:STK11(gene name)|psi-mi:STK11(display_short)|uniprotkb:LKB1(gene name synonym)|uniprotkb:PJS(gene name synonym)|uniprotkb:Liver kinase B1(gene name synonym)|uniprotkb:Renal carcinoma antigen NY-REN-19(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515634|imex:IM-12079-49 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065890.1|ensembl:ENSG00000114742(gene)|ensembl:ENST00000302313(transcript)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0003677"(DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043588"(skin development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0072520"(seminiferous tubule development)|go:"GO:1902525"(regulation of protein monoubiquitination)|go:"GO:1903003"(positive regulation of protein deubiquitination)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR021772|interpro:IPR036322|mint:Q8TAF3|rcsb pdb:5CVL|rcsb pdb:5CVN|rcsb pdb:5CVO|rcsb pdb:5K1A|rcsb pdb:5K1B|rcsb pdb:5K1C|rcsb pdb:5L8E|rcsb pdb:5L8W|rcsb pdb:6JLQ|rcsb pdb:7AY0|rcsb pdb:7AY1|rcsb pdb:7AY2|reactome:R-HSA-110314|reactome:R-HSA-5689880|reactome:R-HSA-6783310|reactome:R-HSA-9673766|refseq:NP_001290331.1|refseq:NP_001290332.1|refseq:NP_001333156.1|refseq:NP_001333157.1|dip:DIP-50841N ensembl:ENSG00000118046(gene)|ensembl:ENST00000326873(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001894"(tissue homeostasis)|go:"GO:0001944"(vasculature development)|go:"GO:0002039"(p53 binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006914"(autophagy)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007409"(axonogenesis)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0016020"(membrane)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030275"(LRR domain binding)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043276"(anoikis)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048814"(regulation of dendrite morphogenesis)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0051645"(Golgi localization)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060770"(negative regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071493"(cellular response to UV-B)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0097484"(dendrite extension)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120163"(negative regulation of cold-induced thermogenesis)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901610"(positive regulation of vesicle transport along microtubule)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1904262"(negative regulation of TORC1 signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR039154|rcsb pdb:2WTK|rcsb pdb:4ZDR|rcsb pdb:5WXN|reactome:R-HSA-163680|interpro:IPR000719(Protein kinase, core)|reactome:R-HSA-380972|reactome:R-HSA-6804756|reactome:R-HSA-9614657|refseq:NP_000446.1|refseq:XP_005259675.1|dip:DIP-31317N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/05/28 rogid:S8ihl3jxEEyMS46AM2ynXSFfCU49606 rogid:zBd9tuO3eqwjdeyPXdKKe6sHPHY9606 intact-crc:FEA84E4597BF2CAC|rigid:5VpwlpQqzlunHNK7tN6q4Wo+lkI false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8TAF3 uniprotkb:Q96B01 intact:EBI-1045469|uniprotkb:Q63HJ2|uniprotkb:Q658Y1|uniprotkb:Q8N3Z1|uniprotkb:Q9NSK8|uniprotkb:Q9P279|uniprotkb:B4DM86|uniprotkb:B4DQI2|uniprotkb:B4DY84|ensembl:ENSP00000307491 intact:EBI-1178724|uniprotkb:O43403|uniprotkb:Q7Z779|uniprotkb:A8K7D3|ensembl:ENSP00000228843 psi-mi:wdr48_human(display_long)|uniprotkb:WD repeat endosomal protein(gene name synonym)|uniprotkb:p80(gene name synonym)|uniprotkb:WDR48(gene name)|psi-mi:WDR48(display_short)|uniprotkb:KIAA1449(gene name synonym)|uniprotkb:UAF1(gene name synonym)|uniprotkb:USP1-associated factor 1(gene name synonym) psi-mi:r51a1_human(display_long)|uniprotkb:RAD51-interacting protein(gene name synonym)|uniprotkb:RAD51AP1(gene name)|psi-mi:RAD51AP1(display_short)|uniprotkb:PIR51(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515634|imex:IM-12079-49 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065890.1|ensembl:ENSG00000114742(gene)|ensembl:ENST00000302313(transcript)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0003677"(DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043588"(skin development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0072520"(seminiferous tubule development)|go:"GO:1902525"(regulation of protein monoubiquitination)|go:"GO:1903003"(positive regulation of protein deubiquitination)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR021772|interpro:IPR036322|mint:Q8TAF3|rcsb pdb:5CVL|rcsb pdb:5CVN|rcsb pdb:5CVO|rcsb pdb:5K1A|rcsb pdb:5K1B|rcsb pdb:5K1C|rcsb pdb:5L8E|rcsb pdb:5L8W|rcsb pdb:6JLQ|rcsb pdb:7AY0|rcsb pdb:7AY1|rcsb pdb:7AY2|reactome:R-HSA-110314|reactome:R-HSA-5689880|reactome:R-HSA-6783310|reactome:R-HSA-9673766|refseq:NP_001290331.1|refseq:NP_001290332.1|refseq:NP_001333156.1|refseq:NP_001333157.1|dip:DIP-50841N refseq:NP_001124334.1|refseq:NP_006470.1|ensembl:ENSG00000111247(gene)|ensembl:ENST00000228843(transcript)|go:"GO:0000217"(DNA secondary structure binding)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010569"(regulation of double-strand break repair via homologous recombination)|go:"GO:0010845"(positive regulation of reciprocal meiotic recombination)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0062037"(D-loop DNA binding)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|interpro:IPR026632|interpro:IPR031419|reactome:R-HSA-5685942|reactome:R-HSA-5693554|reactome:R-HSA-5693568|reactome:R-HSA-5693579|dip:DIP-35257N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/05/28 rogid:S8ihl3jxEEyMS46AM2ynXSFfCU49606 rogid:5f/zzkdZZSmaPFxkg52s60rDnqQ9606 intact-crc:FEA84E4597BF2CAC|rigid:5VpwlpQqzlunHNK7tN6q4Wo+lkI false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8TAF3 uniprotkb:B3KSH1 intact:EBI-1045469|uniprotkb:Q63HJ2|uniprotkb:Q658Y1|uniprotkb:Q8N3Z1|uniprotkb:Q9NSK8|uniprotkb:Q9P279|uniprotkb:B4DM86|uniprotkb:B4DQI2|uniprotkb:B4DY84|ensembl:ENSP00000307491 intact:EBI-2510457 psi-mi:wdr48_human(display_long)|uniprotkb:WD repeat endosomal protein(gene name synonym)|uniprotkb:p80(gene name synonym)|uniprotkb:WDR48(gene name)|psi-mi:WDR48(display_short)|uniprotkb:KIAA1449(gene name synonym)|uniprotkb:UAF1(gene name synonym)|uniprotkb:USP1-associated factor 1(gene name synonym) psi-mi:b3ksh1_human(display_long)|uniprotkb:EIF3F(gene name)|psi-mi:EIF3F(display_short)|uniprotkb:EIF3S5(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 5(gene name synonym)|uniprotkb:eIF-3-epsilon(gene name synonym)|uniprotkb:eIF3 p47(gene name synonym)|uniprotkb:hCG_1784554(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515634|imex:IM-12079-49 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065890.1|ensembl:ENSG00000114742(gene)|ensembl:ENST00000302313(transcript)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0003677"(DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043588"(skin development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0072520"(seminiferous tubule development)|go:"GO:1902525"(regulation of protein monoubiquitination)|go:"GO:1903003"(positive regulation of protein deubiquitination)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR021772|interpro:IPR036322|mint:Q8TAF3|rcsb pdb:5CVL|rcsb pdb:5CVN|rcsb pdb:5CVO|rcsb pdb:5K1A|rcsb pdb:5K1B|rcsb pdb:5K1C|rcsb pdb:5L8E|rcsb pdb:5L8W|rcsb pdb:6JLQ|rcsb pdb:7AY0|rcsb pdb:7AY1|rcsb pdb:7AY2|reactome:R-HSA-110314|reactome:R-HSA-5689880|reactome:R-HSA-6783310|reactome:R-HSA-9673766|refseq:NP_001290331.1|refseq:NP_001290332.1|refseq:NP_001333156.1|refseq:NP_001333157.1|dip:DIP-50841N go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0070122"(isopeptidase activity)|interpro:IPR024969|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR027531|interpro:IPR037518 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/05/28 rogid:S8ihl3jxEEyMS46AM2ynXSFfCU49606 rogid:3xYNX/dcd5LtW8Ne+TP0TYHEUqY9606 intact-crc:FEA84E4597BF2CAC|rigid:5VpwlpQqzlunHNK7tN6q4Wo+lkI false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8TAF3 uniprotkb:Q8TBZ3 intact:EBI-1045469|uniprotkb:Q63HJ2|uniprotkb:Q658Y1|uniprotkb:Q8N3Z1|uniprotkb:Q9NSK8|uniprotkb:Q9P279|uniprotkb:B4DM86|uniprotkb:B4DQI2|uniprotkb:B4DY84|ensembl:ENSP00000307491 intact:EBI-2511486|ensembl:ENSP00000341037|uniprotkb:Q8WXX2|uniprotkb:Q9UF86|uniprotkb:Q8NCN7|intact:EBI-11109494|uniprotkb:H0YJJ1|uniprotkb:Q86TU2|uniprotkb:B4DN18|uniprotkb:E7EUY8|uniprotkb:F8W9S4|uniprotkb:G3V2F8|uniprotkb:G3V5R0 psi-mi:wdr48_human(display_long)|uniprotkb:WD repeat endosomal protein(gene name synonym)|uniprotkb:p80(gene name synonym)|uniprotkb:WDR48(gene name)|psi-mi:WDR48(display_short)|uniprotkb:KIAA1449(gene name synonym)|uniprotkb:UAF1(gene name synonym)|uniprotkb:USP1-associated factor 1(gene name synonym) psi-mi:wdr20_human(display_long)|uniprotkb:WDR20(gene name)|psi-mi:WDR20(display_short)|uniprotkb:Protein DMR(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515634|imex:IM-12079-49 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065890.1|ensembl:ENSG00000114742(gene)|ensembl:ENST00000302313(transcript)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0003677"(DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043588"(skin development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0072520"(seminiferous tubule development)|go:"GO:1902525"(regulation of protein monoubiquitination)|go:"GO:1903003"(positive regulation of protein deubiquitination)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR021772|interpro:IPR036322|mint:Q8TAF3|rcsb pdb:5CVL|rcsb pdb:5CVN|rcsb pdb:5CVO|rcsb pdb:5K1A|rcsb pdb:5K1B|rcsb pdb:5K1C|rcsb pdb:5L8E|rcsb pdb:5L8W|rcsb pdb:6JLQ|rcsb pdb:7AY0|rcsb pdb:7AY1|rcsb pdb:7AY2|reactome:R-HSA-110314|reactome:R-HSA-5689880|reactome:R-HSA-6783310|reactome:R-HSA-9673766|refseq:NP_001290331.1|refseq:NP_001290332.1|refseq:NP_001333156.1|refseq:NP_001333157.1|dip:DIP-50841N ensembl:ENSG00000140153(gene)|ensembl:ENST00000342702(transcript)|go:"GO:0005654"(nucleoplasm)|interpro:IPR001680(WD40 repeat)|interpro:IPR036322|mint:Q8TBZ3|rcsb pdb:5K19|rcsb pdb:5K1C|rcsb pdb:6JLQ|reactome:R-HSA-5689880|refseq:NP_001229343.1|refseq:NP_001229345.1|refseq:NP_001229346.1|refseq:NP_001229347.1|refseq:NP_653175.2|refseq:NP_851808.1|refseq:NP_851825.1|refseq:NP_001229344.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/05/28 rogid:S8ihl3jxEEyMS46AM2ynXSFfCU49606 rogid:2MfZps9YU8xQbWazkq2sIqXjHHg9606 intact-crc:FEA84E4597BF2CAC|rigid:5VpwlpQqzlunHNK7tN6q4Wo+lkI false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8TAF3 uniprotkb:P61289 intact:EBI-1045469|uniprotkb:Q63HJ2|uniprotkb:Q658Y1|uniprotkb:Q8N3Z1|uniprotkb:Q9NSK8|uniprotkb:Q9P279|uniprotkb:B4DM86|uniprotkb:B4DQI2|uniprotkb:B4DY84|ensembl:ENSP00000307491 intact:EBI-355546|uniprotkb:O35563|uniprotkb:P97373|uniprotkb:Q12920|uniprotkb:Q13172|uniprotkb:Q9BQD9|uniprotkb:A8K9A3|ensembl:ENSP00000466794 psi-mi:wdr48_human(display_long)|uniprotkb:WD repeat endosomal protein(gene name synonym)|uniprotkb:p80(gene name synonym)|uniprotkb:WDR48(gene name)|psi-mi:WDR48(display_short)|uniprotkb:KIAA1449(gene name synonym)|uniprotkb:UAF1(gene name synonym)|uniprotkb:USP1-associated factor 1(gene name synonym) psi-mi:psme3_human(display_long)|uniprotkb:PSME3(gene name)|psi-mi:PSME3(display_short)|uniprotkb:Proteasome activator 28 subunit gamma(gene name synonym)|uniprotkb:Activator of multicatalytic protease subunit 3(gene name synonym)|uniprotkb:11S regulator complex subunit gamma(gene name synonym)|uniprotkb:Ki nuclear autoantigen(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515634|imex:IM-12079-49 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065890.1|ensembl:ENSG00000114742(gene)|ensembl:ENST00000302313(transcript)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0003677"(DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043588"(skin development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0072520"(seminiferous tubule development)|go:"GO:1902525"(regulation of protein monoubiquitination)|go:"GO:1903003"(positive regulation of protein deubiquitination)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR021772|interpro:IPR036322|mint:Q8TAF3|rcsb pdb:5CVL|rcsb pdb:5CVN|rcsb pdb:5CVO|rcsb pdb:5K1A|rcsb pdb:5K1B|rcsb pdb:5K1C|rcsb pdb:5L8E|rcsb pdb:5L8W|rcsb pdb:6JLQ|rcsb pdb:7AY0|rcsb pdb:7AY1|rcsb pdb:7AY2|reactome:R-HSA-110314|reactome:R-HSA-5689880|reactome:R-HSA-6783310|reactome:R-HSA-9673766|refseq:NP_001290331.1|refseq:NP_001290332.1|refseq:NP_001333156.1|refseq:NP_001333157.1|dip:DIP-50841N refseq:NP_005780.2|refseq:NP_789839.1|ensembl:ENSG00000131467(gene)|ensembl:ENST00000590720(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0002039"(p53 binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0008537"(proteasome activator complex)|go:"GO:0010950"(positive regulation of endopeptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0061133"(endopeptidase activator activity)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR003185(Proteasome activator pa28, REG alpha subunit)|interpro:IPR003186(Proteasome activator pa28, REG beta subunit)|interpro:IPR009077(Proteasome activator pa28, REG alpha/beta subunit)|interpro:IPR036252|interpro:IPR036996|interpro:IPR036997|mint:P61289|reactome:R-HSA-1169091|reactome:R-HSA-1234176|reactome:R-HSA-1236974|reactome:R-HSA-1236978|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-211733|reactome:R-HSA-2467813|reactome:R-HSA-2871837|reactome:R-HSA-349425|reactome:R-HSA-350562|reactome:R-HSA-382556|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689880|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69481|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8852276|reactome:R-HSA-8854050|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-8948751|reactome:R-HSA-8951664|reactome:R-HSA-9010553|reactome:R-HSA-9020702|reactome:R-HSA-9604323|reactome:R-HSA-983168 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/05/28 rogid:S8ihl3jxEEyMS46AM2ynXSFfCU49606 rogid:6EQY2Kj3Juf++m4eBDzPWMgbC2k9606 intact-crc:FEA84E4597BF2CAC|rigid:5VpwlpQqzlunHNK7tN6q4Wo+lkI false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8TAF3 uniprotkb:Q6PI26 intact:EBI-1045469|uniprotkb:Q63HJ2|uniprotkb:Q658Y1|uniprotkb:Q8N3Z1|uniprotkb:Q9NSK8|uniprotkb:Q9P279|uniprotkb:B4DM86|uniprotkb:B4DQI2|uniprotkb:B4DY84|ensembl:ENSP00000307491 intact:EBI-2515568|ensembl:ENSP00000315182|uniprotkb:Q9NVS8|uniprotkb:Q9H7E5|uniprotkb:Q7Z748|uniprotkb:Q6MZJ4|uniprotkb:B4DL05|intact:EBI-11117026 psi-mi:wdr48_human(display_long)|uniprotkb:WD repeat endosomal protein(gene name synonym)|uniprotkb:p80(gene name synonym)|uniprotkb:WDR48(gene name)|psi-mi:WDR48(display_short)|uniprotkb:KIAA1449(gene name synonym)|uniprotkb:UAF1(gene name synonym)|uniprotkb:USP1-associated factor 1(gene name synonym) psi-mi:shq1_human(display_long)|uniprotkb:SHQ1(gene name)|psi-mi:SHQ1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515634|imex:IM-12079-49 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065890.1|ensembl:ENSG00000114742(gene)|ensembl:ENST00000302313(transcript)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0003677"(DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043588"(skin development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0072520"(seminiferous tubule development)|go:"GO:1902525"(regulation of protein monoubiquitination)|go:"GO:1903003"(positive regulation of protein deubiquitination)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR021772|interpro:IPR036322|mint:Q8TAF3|rcsb pdb:5CVL|rcsb pdb:5CVN|rcsb pdb:5CVO|rcsb pdb:5K1A|rcsb pdb:5K1B|rcsb pdb:5K1C|rcsb pdb:5L8E|rcsb pdb:5L8W|rcsb pdb:6JLQ|rcsb pdb:7AY0|rcsb pdb:7AY1|rcsb pdb:7AY2|reactome:R-HSA-110314|reactome:R-HSA-5689880|reactome:R-HSA-6783310|reactome:R-HSA-9673766|refseq:NP_001290331.1|refseq:NP_001290332.1|refseq:NP_001333156.1|refseq:NP_001333157.1|dip:DIP-50841N ensembl:ENSG00000144736(gene)|ensembl:ENST00000325599(transcript)|go:"GO:0000493"(box H/ACA snoRNP assembly)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0022618"(ribonucleoprotein complex assembly)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0051082"(unfolded protein binding)|go:"GO:1904874"(positive regulation of telomerase RNA localization to Cajal body)|go:"GO:2000233"(negative regulation of rRNA processing)|interpro:IPR007009(SHQ1 protein)|interpro:IPR007052(CS domain)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR039742|rcsb pdb:2MNW|rcsb pdb:4PBD|rcsb pdb:4PCK|reactome:R-HSA-171319|refseq:NP_060600.2 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/05/28 rogid:S8ihl3jxEEyMS46AM2ynXSFfCU49606 rogid:3KeAEUXMDvt/j992j14qoCP9onk9606 intact-crc:FEA84E4597BF2CAC|rigid:5VpwlpQqzlunHNK7tN6q4Wo+lkI false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8TAF3 uniprotkb:O94782 intact:EBI-1045469|uniprotkb:Q63HJ2|uniprotkb:Q658Y1|uniprotkb:Q8N3Z1|uniprotkb:Q9NSK8|uniprotkb:Q9P279|uniprotkb:B4DM86|uniprotkb:B4DQI2|uniprotkb:B4DY84|ensembl:ENSP00000307491 intact:EBI-2513396|ensembl:ENSP00000343526|ensembl:ENSP00000360188|uniprotkb:Q9UNJ3|uniprotkb:A0PJ95|uniprotkb:Q9UFR0|uniprotkb:Q59H66|uniprotkb:Q05BX7|uniprotkb:D3DQ57 psi-mi:wdr48_human(display_long)|uniprotkb:WD repeat endosomal protein(gene name synonym)|uniprotkb:p80(gene name synonym)|uniprotkb:WDR48(gene name)|psi-mi:WDR48(display_short)|uniprotkb:KIAA1449(gene name synonym)|uniprotkb:UAF1(gene name synonym)|uniprotkb:USP1-associated factor 1(gene name synonym) psi-mi:ubp1_human(display_long)|uniprotkb:USP1(gene name)|psi-mi:USP1(display_short)|uniprotkb:Ubiquitin-specific-processing protease 1(gene name synonym)|uniprotkb:Deubiquitinating enzyme 1(gene name synonym)|uniprotkb:Ubiquitin thioesterase 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515634|imex:IM-12079-49 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065890.1|ensembl:ENSG00000114742(gene)|ensembl:ENST00000302313(transcript)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0003677"(DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043588"(skin development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0072520"(seminiferous tubule development)|go:"GO:1902525"(regulation of protein monoubiquitination)|go:"GO:1903003"(positive regulation of protein deubiquitination)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR021772|interpro:IPR036322|mint:Q8TAF3|rcsb pdb:5CVL|rcsb pdb:5CVN|rcsb pdb:5CVO|rcsb pdb:5K1A|rcsb pdb:5K1B|rcsb pdb:5K1C|rcsb pdb:5L8E|rcsb pdb:5L8W|rcsb pdb:6JLQ|rcsb pdb:7AY0|rcsb pdb:7AY1|rcsb pdb:7AY2|reactome:R-HSA-110314|reactome:R-HSA-5689880|reactome:R-HSA-6783310|reactome:R-HSA-9673766|refseq:NP_001290331.1|refseq:NP_001290332.1|refseq:NP_001333156.1|refseq:NP_001333157.1|dip:DIP-50841N ensembl:ENSG00000162607(gene)|ensembl:ENST00000339950(transcript)|ensembl:ENST00000371146(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006282"(regulation of DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008233"(peptidase activity)|go:"GO:0009411"(response to UV)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035520"(monoubiquitinated protein deubiquitination)|go:"GO:0042769"(obsolete DNA damage response, detection of DNA damage)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR033815|interpro:IPR038765|mint:O94782|rcsb pdb:6DO5|rcsb pdb:7AY0|rcsb pdb:7AY1|rcsb pdb:7AY2|reactome:R-HSA-110314|reactome:R-HSA-6783310|refseq:NP_001017415.1|refseq:NP_001017416.1|refseq:NP_003359.3|dip:DIP-53609N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/05/28 rogid:S8ihl3jxEEyMS46AM2ynXSFfCU49606 rogid:cSWX5JiI+vqbREjhCJeCGAiiVzE9606 intact-crc:FEA84E4597BF2CAC|rigid:5VpwlpQqzlunHNK7tN6q4Wo+lkI false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8TAF3 uniprotkb:Q9NX24 intact:EBI-1045469|uniprotkb:Q63HJ2|uniprotkb:Q658Y1|uniprotkb:Q8N3Z1|uniprotkb:Q9NSK8|uniprotkb:Q9P279|uniprotkb:B4DM86|uniprotkb:B4DQI2|uniprotkb:B4DY84|ensembl:ENSP00000307491 intact:EBI-1050064|uniprotkb:Q9P095|uniprotkb:A6NKY8|intact:EBI-5774108|ensembl:ENSP00000274606 psi-mi:wdr48_human(display_long)|uniprotkb:WD repeat endosomal protein(gene name synonym)|uniprotkb:p80(gene name synonym)|uniprotkb:WDR48(gene name)|psi-mi:WDR48(display_short)|uniprotkb:KIAA1449(gene name synonym)|uniprotkb:UAF1(gene name synonym)|uniprotkb:USP1-associated factor 1(gene name synonym) psi-mi:nhp2_human(display_long)|uniprotkb:Nucleolar protein family A member 2(gene name synonym)|uniprotkb:snoRNP protein NHP2(gene name synonym)|uniprotkb:NHP2(gene name)|psi-mi:NHP2(display_short)|uniprotkb:NOLA2(gene name synonym)|uniprotkb:HSPC286(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515634|imex:IM-12079-49 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065890.1|ensembl:ENSG00000114742(gene)|ensembl:ENST00000302313(transcript)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0003677"(DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043588"(skin development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0072520"(seminiferous tubule development)|go:"GO:1902525"(regulation of protein monoubiquitination)|go:"GO:1903003"(positive regulation of protein deubiquitination)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR021772|interpro:IPR036322|mint:Q8TAF3|rcsb pdb:5CVL|rcsb pdb:5CVN|rcsb pdb:5CVO|rcsb pdb:5K1A|rcsb pdb:5K1B|rcsb pdb:5K1C|rcsb pdb:5L8E|rcsb pdb:5L8W|rcsb pdb:6JLQ|rcsb pdb:7AY0|rcsb pdb:7AY1|rcsb pdb:7AY2|reactome:R-HSA-110314|reactome:R-HSA-5689880|reactome:R-HSA-6783310|reactome:R-HSA-9673766|refseq:NP_001290331.1|refseq:NP_001290332.1|refseq:NP_001333156.1|refseq:NP_001333157.1|dip:DIP-50841N refseq:NP_060308.1|refseq:NP_001030005.1|ensembl:ENSG00000145912(gene)|ensembl:ENST00000274606(transcript)|go:"GO:0000469"(cleavage involved in rRNA processing)|go:"GO:0000470"(maturation of LSU-rRNA)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0005732"("sno(s)RNA-containing ribonucleoprotein complex")|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0031118"(rRNA pseudouridine synthesis)|go:"GO:0031120"(snRNA pseudouridine synthesis)|go:"GO:0031429"(box H/ACA snoRNP complex)|go:"GO:0034513"(box H/ACA snoRNA binding)|go:"GO:0070034"(telomerase RNA binding)|go:"GO:0072589"(box H/ACA scaRNP complex)|go:"GO:0090661"(box H/ACA telomerase RNP complex)|go:"GO:1904874"(positive regulation of telomerase RNA localization to Cajal body)|interpro:IPR002415(High mobility group-like nuclear protein)|interpro:IPR004038(Ribosomal protein L7Ae/L30e/S12e/Gadd45)|interpro:IPR018492|interpro:IPR029064|mint:Q9NX24|rcsb pdb:7BGB|reactome:R-HSA-171319|reactome:R-HSA-6790901 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/05/28 rogid:S8ihl3jxEEyMS46AM2ynXSFfCU49606 rogid:ZZchZSzrw15BqMfddUMcaxZRF0w9606 intact-crc:FEA84E4597BF2CAC|rigid:5VpwlpQqzlunHNK7tN6q4Wo+lkI false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8TAF3 uniprotkb:P67870 intact:EBI-1045469|uniprotkb:Q63HJ2|uniprotkb:Q658Y1|uniprotkb:Q8N3Z1|uniprotkb:Q9NSK8|uniprotkb:Q9P279|uniprotkb:B4DM86|uniprotkb:B4DQI2|uniprotkb:B4DY84|ensembl:ENSP00000307491 intact:EBI-348169|ensembl:ENSP00000365025|ensembl:ENSP00000365026|ensembl:ENSP00000365042|ensembl:ENSP00000372919|ensembl:ENSP00000372925|ensembl:ENSP00000382980|ensembl:ENSP00000390900|ensembl:ENSP00000391038|ensembl:ENSP00000393756|ensembl:ENSP00000394855|ensembl:ENSP00000395275|ensembl:ENSP00000400188|ensembl:ENSP00000407018|ensembl:ENSP00000407379|ensembl:ENSP00000409510|ensembl:ENSP00000410802|ensembl:ENSP00000411322|ensembl:ENSP00000412520|ensembl:ENSP00000413469|ensembl:ENSP00000415237|ensembl:ENSP00000415303|uniprotkb:P07312|uniprotkb:P13862|uniprotkb:Q4VX47|intact:EBI-3866975|uniprotkb:B0UXA9 psi-mi:wdr48_human(display_long)|uniprotkb:WD repeat endosomal protein(gene name synonym)|uniprotkb:p80(gene name synonym)|uniprotkb:WDR48(gene name)|psi-mi:WDR48(display_short)|uniprotkb:KIAA1449(gene name synonym)|uniprotkb:UAF1(gene name synonym)|uniprotkb:USP1-associated factor 1(gene name synonym) psi-mi:csk2b_human(display_long)|uniprotkb:Phosvitin(gene name synonym)|uniprotkb:Protein G5a(gene name synonym)|uniprotkb:CSNK2B(gene name)|psi-mi:CSNK2B(display_short)|uniprotkb:CK2N(gene name synonym)|uniprotkb:G5A(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515634|imex:IM-12079-49 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065890.1|ensembl:ENSG00000114742(gene)|ensembl:ENST00000302313(transcript)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0003677"(DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043588"(skin development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0072520"(seminiferous tubule development)|go:"GO:1902525"(regulation of protein monoubiquitination)|go:"GO:1903003"(positive regulation of protein deubiquitination)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR021772|interpro:IPR036322|mint:Q8TAF3|rcsb pdb:5CVL|rcsb pdb:5CVN|rcsb pdb:5CVO|rcsb pdb:5K1A|rcsb pdb:5K1B|rcsb pdb:5K1C|rcsb pdb:5L8E|rcsb pdb:5L8W|rcsb pdb:6JLQ|rcsb pdb:7AY0|rcsb pdb:7AY1|rcsb pdb:7AY2|reactome:R-HSA-110314|reactome:R-HSA-5689880|reactome:R-HSA-6783310|reactome:R-HSA-9673766|refseq:NP_001290331.1|refseq:NP_001290332.1|refseq:NP_001333156.1|refseq:NP_001333157.1|dip:DIP-50841N ensembl:ENSG00000204435(gene)|ensembl:ENSG00000230700(gene)|ensembl:ENSG00000206406(gene)|ensembl:ENSG00000232960(gene)|ensembl:ENSG00000224398(gene)|ensembl:ENSG00000224774(gene)|ensembl:ENSG00000228875(gene)|ensembl:ENST00000375882(transcript)|ensembl:ENST00000383427(transcript)|ensembl:ENST00000383433(transcript)|ensembl:ENST00000400110(transcript)|ensembl:ENST00000412802(transcript)|ensembl:ENST00000418230(transcript)|ensembl:ENST00000422567(transcript)|ensembl:ENST00000429633(transcript)|ensembl:ENST00000431476(transcript)|ensembl:ENST00000436169(transcript)|ensembl:ENST00000443673(transcript)|ensembl:ENST00000448596(transcript)|ensembl:ENST00000451917(transcript)|ensembl:ENST00000452985(transcript)|ensembl:ENST00000453234(transcript)|ensembl:ENST00000454382(transcript)|ensembl:ENST00000454511(transcript)|ensembl:ENST00000455161(transcript)|ensembl:ENST00000458330(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0005956"(protein kinase CK2 complex)|go:"GO:0007165"(signal transduction)|ensembl:ENST00000375865(transcript)|ensembl:ENST00000375866(transcript)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016363"(nuclear matrix)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032927"(positive regulation of activin receptor signaling pathway)|go:"GO:0033211"(adiponectin-activated signaling pathway)|go:"GO:0033574"(response to testosterone)|go:"GO:0034622"|go:"GO:0034774"(secretory granule lumen)|go:"GO:0042802"(identical protein binding)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043537"(negative regulation of blood vessel endothelial cell migration)|go:"GO:0046872"(metal ion binding)|go:"GO:0051101"(regulation of DNA binding)|go:"GO:0061154"(endothelial tube morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0080163"(regulation of protein serine/threonine phosphatase activity)|go:"GO:0097421"(liver regeneration)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000704(Casein kinase II, regulatory subunit)|interpro:IPR016149(Casein kinase II, regulatory subunit, alpha-helical)|interpro:IPR035991|mint:P67870|rcsb pdb:1DS5|rcsb pdb:1JWH|go:"GO:0008134"(transcription factor binding)|rcsb pdb:1QF8|rcsb pdb:3EED|rcsb pdb:4DGL|rcsb pdb:4MD7|rcsb pdb:4MD8|rcsb pdb:4MD9|rcsb pdb:4NH1|reactome:R-HSA-1483191|reactome:R-HSA-201688|reactome:R-HSA-2514853|reactome:R-HSA-445144|reactome:R-HSA-6798695|reactome:R-HSA-6804756|reactome:R-HSA-6814122|reactome:R-HSA-8932339|reactome:R-HSA-8934903|reactome:R-HSA-8939243|reactome:R-HSA-8948751|rcsb pdb:6Q38|refseq:NP_001311.3|refseq:NP_001269314.1|dip:DIP-131N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/05/28 rogid:S8ihl3jxEEyMS46AM2ynXSFfCU49606 rogid:ZTHJjCqHg2dE7B+WoSU28VSMuPg9606 intact-crc:FEA84E4597BF2CAC|rigid:5VpwlpQqzlunHNK7tN6q4Wo+lkI false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8TAF3 uniprotkb:Q01105 intact:EBI-1045469|uniprotkb:Q63HJ2|uniprotkb:Q658Y1|uniprotkb:Q8N3Z1|uniprotkb:Q9NSK8|uniprotkb:Q9P279|uniprotkb:B4DM86|uniprotkb:B4DQI2|uniprotkb:B4DY84|ensembl:ENSP00000307491 intact:EBI-1053182|uniprotkb:A5A5H4|uniprotkb:Q15541|uniprotkb:Q5VXV1|uniprotkb:Q6FHZ5|intact:EBI-2559610|uniprotkb:A6NGV1|uniprotkb:B4DUE2|intact:EBI-4290953|uniprotkb:Q5VXV2|ensembl:ENSP00000361777 psi-mi:wdr48_human(display_long)|uniprotkb:WD repeat endosomal protein(gene name synonym)|uniprotkb:p80(gene name synonym)|uniprotkb:WDR48(gene name)|psi-mi:WDR48(display_short)|uniprotkb:KIAA1449(gene name synonym)|uniprotkb:UAF1(gene name synonym)|uniprotkb:USP1-associated factor 1(gene name synonym) psi-mi:set_human(display_long)|uniprotkb:Phosphatase 2A inhibitor I2PP2A(gene name synonym)|uniprotkb:Template-activating factor I(gene name synonym)|uniprotkb:HLA-DR-associated protein II(gene name synonym)|uniprotkb:PHAPII(gene name synonym)|uniprotkb:Inhibitor of granzyme A-activated DNase(gene name synonym)|uniprotkb:SET(gene name)|psi-mi:SET(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515634|imex:IM-12079-49 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065890.1|ensembl:ENSG00000114742(gene)|ensembl:ENST00000302313(transcript)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0003677"(DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043588"(skin development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0072520"(seminiferous tubule development)|go:"GO:1902525"(regulation of protein monoubiquitination)|go:"GO:1903003"(positive regulation of protein deubiquitination)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR021772|interpro:IPR036322|mint:Q8TAF3|rcsb pdb:5CVL|rcsb pdb:5CVN|rcsb pdb:5CVO|rcsb pdb:5K1A|rcsb pdb:5K1B|rcsb pdb:5K1C|rcsb pdb:5L8E|rcsb pdb:5L8W|rcsb pdb:6JLQ|rcsb pdb:7AY0|rcsb pdb:7AY1|rcsb pdb:7AY2|reactome:R-HSA-110314|reactome:R-HSA-5689880|reactome:R-HSA-6783310|reactome:R-HSA-9673766|refseq:NP_001290331.1|refseq:NP_001290332.1|refseq:NP_001333156.1|refseq:NP_001333157.1|dip:DIP-50841N refseq:NP_001116293.1|refseq:NP_003002.2|dip:DIP-33561N|refseq:NP_001234930.1|refseq:NP_001234929.1|ensembl:ENSG00000119335(gene)|ensembl:ENST00000372692(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0004864"(protein phosphatase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0006337"(nucleosome disassembly)|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042393"(histone binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|interpro:IPR002164("Nucleosome assembly protein (NAP)")|interpro:IPR037231|mint:Q01105|rcsb pdb:2E50|rcsb pdb:7MTO|reactome:R-HSA-2299718|reactome:R-HSA-450520|go:"GO:0035067"(negative regulation of histone acetylation) psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/05/28 rogid:S8ihl3jxEEyMS46AM2ynXSFfCU49606 rogid:CBwf28rN/LSY/vhw7jxRHKP8q0k9606 intact-crc:FEA84E4597BF2CAC|rigid:5VpwlpQqzlunHNK7tN6q4Wo+lkI false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8TAF3 uniprotkb:B1AM27 intact:EBI-1045469|uniprotkb:Q63HJ2|uniprotkb:Q658Y1|uniprotkb:Q8N3Z1|uniprotkb:Q9NSK8|uniprotkb:Q9P279|uniprotkb:B4DM86|uniprotkb:B4DQI2|uniprotkb:B4DY84|ensembl:ENSP00000307491 intact:EBI-2515592|ensembl:ENSP00000380006 psi-mi:wdr48_human(display_long)|uniprotkb:WD repeat endosomal protein(gene name synonym)|uniprotkb:p80(gene name synonym)|uniprotkb:WDR48(gene name)|psi-mi:WDR48(display_short)|uniprotkb:KIAA1449(gene name synonym)|uniprotkb:UAF1(gene name synonym)|uniprotkb:USP1-associated factor 1(gene name synonym) psi-mi:b1am27_human(display_long)|uniprotkb:UNC13B(gene name)|psi-mi:UNC13B(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515634|imex:IM-12079-49 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065890.1|ensembl:ENSG00000114742(gene)|ensembl:ENST00000302313(transcript)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0003677"(DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043588"(skin development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0072520"(seminiferous tubule development)|go:"GO:1902525"(regulation of protein monoubiquitination)|go:"GO:1903003"(positive regulation of protein deubiquitination)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR021772|interpro:IPR036322|mint:Q8TAF3|rcsb pdb:5CVL|rcsb pdb:5CVN|rcsb pdb:5CVO|rcsb pdb:5K1A|rcsb pdb:5K1B|rcsb pdb:5K1C|rcsb pdb:5L8E|rcsb pdb:5L8W|rcsb pdb:6JLQ|rcsb pdb:7AY0|rcsb pdb:7AY1|rcsb pdb:7AY2|reactome:R-HSA-110314|reactome:R-HSA-5689880|reactome:R-HSA-6783310|reactome:R-HSA-9673766|refseq:NP_001290331.1|refseq:NP_001290332.1|refseq:NP_001333156.1|refseq:NP_001333157.1|dip:DIP-50841N ensembl:ENSG00000198722(gene)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0006887"(exocytosis)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0019992"(diacylglycerol binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0045202"(synapse)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR010439(Protein of unknown function DUF1041)|interpro:IPR014770(Munc13 homology 1)|interpro:IPR014772(Munc13 homology 2)|interpro:IPR019558|interpro:IPR027080|interpro:IPR035892|interpro:IPR037302|ensembl:ENST00000396787(transcript) psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/05/28 rogid:S8ihl3jxEEyMS46AM2ynXSFfCU49606 rogid:TyxN9qliks7l4/8XNvoB1uby+TA9606 intact-crc:FEA84E4597BF2CAC|rigid:5VpwlpQqzlunHNK7tN6q4Wo+lkI false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8TAF3 uniprotkb:P19784 intact:EBI-1045469|uniprotkb:Q63HJ2|uniprotkb:Q658Y1|uniprotkb:Q8N3Z1|uniprotkb:Q9NSK8|uniprotkb:Q9P279|uniprotkb:B4DM86|uniprotkb:B4DQI2|uniprotkb:B4DY84|ensembl:ENSP00000307491 intact:EBI-347451|ensembl:ENSP00000262506 psi-mi:wdr48_human(display_long)|uniprotkb:WD repeat endosomal protein(gene name synonym)|uniprotkb:p80(gene name synonym)|uniprotkb:WDR48(gene name)|psi-mi:WDR48(display_short)|uniprotkb:KIAA1449(gene name synonym)|uniprotkb:UAF1(gene name synonym)|uniprotkb:USP1-associated factor 1(gene name synonym) psi-mi:csk22_human(display_long)|uniprotkb:CSNK2A2(gene name)|psi-mi:CSNK2A2(display_short)|uniprotkb:CK2A2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515634|imex:IM-12079-49 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065890.1|ensembl:ENSG00000114742(gene)|ensembl:ENST00000302313(transcript)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0003677"(DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043588"(skin development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0072520"(seminiferous tubule development)|go:"GO:1902525"(regulation of protein monoubiquitination)|go:"GO:1903003"(positive regulation of protein deubiquitination)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR021772|interpro:IPR036322|mint:Q8TAF3|rcsb pdb:5CVL|rcsb pdb:5CVN|rcsb pdb:5CVO|rcsb pdb:5K1A|rcsb pdb:5K1B|rcsb pdb:5K1C|rcsb pdb:5L8E|rcsb pdb:5L8W|rcsb pdb:6JLQ|rcsb pdb:7AY0|rcsb pdb:7AY1|rcsb pdb:7AY2|reactome:R-HSA-110314|reactome:R-HSA-5689880|reactome:R-HSA-6783310|reactome:R-HSA-9673766|refseq:NP_001290331.1|refseq:NP_001290332.1|refseq:NP_001333156.1|refseq:NP_001333157.1|dip:DIP-50841N refseq:NP_001887.1|dip:DIP-318N|ensembl:ENSG00000070770(gene)|ensembl:ENST00000262506(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005956"(protein kinase CK2 complex)|go:"GO:0006915"(apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0007283"(spermatogenesis)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0097421"(liver regeneration)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903146"(regulation of autophagy of mitochondrion)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1905818"(regulation of chromosome separation)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P19784|rcsb pdb:3E3B|rcsb pdb:3OFM|rcsb pdb:3U87|rcsb pdb:5M4U|rcsb pdb:5M56|rcsb pdb:5OOI|rcsb pdb:5Y9M|rcsb pdb:5YF9|rcsb pdb:5YWM|rcsb pdb:6HMB|rcsb pdb:6HMC|rcsb pdb:6HMD|rcsb pdb:6HMQ|rcsb pdb:6L20|rcsb pdb:6QY8|rcsb pdb:6QY9|rcsb pdb:6TE2|rcsb pdb:6TEW|rcsb pdb:6TGU|rcsb pdb:7A1B|rcsb pdb:7A1Z|rcsb pdb:7A22|rcsb pdb:7A2H|reactome:R-HSA-1483191|reactome:R-HSA-201688|reactome:R-HSA-2514853|reactome:R-HSA-445144|reactome:R-HSA-6804756|reactome:R-HSA-6814122|reactome:R-HSA-8932339|reactome:R-HSA-8934903|reactome:R-HSA-8939243|reactome:R-HSA-8948751 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/05/28 rogid:S8ihl3jxEEyMS46AM2ynXSFfCU49606 rogid:SIekW2yzNePP9hLKW7OHNFBwNck9606 intact-crc:FEA84E4597BF2CAC|rigid:5VpwlpQqzlunHNK7tN6q4Wo+lkI false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8TAF3 uniprotkb:P49750 intact:EBI-1045469|uniprotkb:Q63HJ2|uniprotkb:Q658Y1|uniprotkb:Q8N3Z1|uniprotkb:Q9NSK8|uniprotkb:Q9P279|uniprotkb:B4DM86|uniprotkb:B4DQI2|uniprotkb:B4DY84|ensembl:ENSP00000307491 intact:EBI-712871|ensembl:ENSP00000324463|uniprotkb:P49752|uniprotkb:Q96I64|uniprotkb:Q9P1V7 psi-mi:wdr48_human(display_long)|uniprotkb:WD repeat endosomal protein(gene name synonym)|uniprotkb:p80(gene name synonym)|uniprotkb:WDR48(gene name)|psi-mi:WDR48(display_short)|uniprotkb:KIAA1449(gene name synonym)|uniprotkb:UAF1(gene name synonym)|uniprotkb:USP1-associated factor 1(gene name synonym) psi-mi:ylpm1_human(display_long)|uniprotkb:Nuclear protein ZAP3(gene name synonym)|uniprotkb:ZAP113(gene name synonym)|uniprotkb:YLPM1(gene name)|psi-mi:YLPM1(display_short)|uniprotkb:C14orf170(gene name synonym)|uniprotkb:ZAP3(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515634|imex:IM-12079-49 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065890.1|ensembl:ENSG00000114742(gene)|ensembl:ENST00000302313(transcript)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0003677"(DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043588"(skin development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0072520"(seminiferous tubule development)|go:"GO:1902525"(regulation of protein monoubiquitination)|go:"GO:1903003"(positive regulation of protein deubiquitination)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR021772|interpro:IPR036322|mint:Q8TAF3|rcsb pdb:5CVL|rcsb pdb:5CVN|rcsb pdb:5CVO|rcsb pdb:5K1A|rcsb pdb:5K1B|rcsb pdb:5K1C|rcsb pdb:5L8E|rcsb pdb:5L8W|rcsb pdb:6JLQ|rcsb pdb:7AY0|rcsb pdb:7AY1|rcsb pdb:7AY2|reactome:R-HSA-110314|reactome:R-HSA-5689880|reactome:R-HSA-6783310|reactome:R-HSA-9673766|refseq:NP_001290331.1|refseq:NP_001290332.1|refseq:NP_001333156.1|refseq:NP_001333157.1|dip:DIP-50841N ensembl:ENSG00000119596(gene)|ensembl:ENST00000325680(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016607"(nuclear speck)|go:"GO:0032204"(regulation of telomere maintenance)|interpro:IPR026314|interpro:IPR027417|refseq:NP_062535.2|ensembl:ENSP00000324463|dip:DIP-53676N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/05/28 rogid:S8ihl3jxEEyMS46AM2ynXSFfCU49606 rogid:3w+7odPC5D2UQYimwmCgTBbvWR49606 intact-crc:FEA84E4597BF2CAC|rigid:5VpwlpQqzlunHNK7tN6q4Wo+lkI false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8TAF3 uniprotkb:O60832 intact:EBI-1045469|uniprotkb:Q63HJ2|uniprotkb:Q658Y1|uniprotkb:Q8N3Z1|uniprotkb:Q9NSK8|uniprotkb:Q9P279|uniprotkb:B4DM86|uniprotkb:B4DQI2|uniprotkb:B4DY84|ensembl:ENSP00000307491 intact:EBI-713091|ensembl:ENSP00000358563|uniprotkb:O43845|uniprotkb:Q96G67|uniprotkb:Q9Y505|uniprotkb:F5BSB3 psi-mi:wdr48_human(display_long)|uniprotkb:WD repeat endosomal protein(gene name synonym)|uniprotkb:p80(gene name synonym)|uniprotkb:WDR48(gene name)|psi-mi:WDR48(display_short)|uniprotkb:KIAA1449(gene name synonym)|uniprotkb:UAF1(gene name synonym)|uniprotkb:USP1-associated factor 1(gene name synonym) psi-mi:dkc1_human(display_long)|uniprotkb:Dyskerin(gene name synonym)|uniprotkb:Nucleolar protein family A member 4(gene name synonym)|uniprotkb:snoRNP protein DKC1(gene name synonym)|uniprotkb:Nopp140-associated protein of 57 kDa(gene name synonym)|uniprotkb:Nucleolar protein NAP57(gene name synonym)|uniprotkb:CBF5 homolog(gene name synonym)|uniprotkb:DKC1(gene name)|psi-mi:DKC1(display_short)|uniprotkb:NOLA4(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515634|imex:IM-12079-49 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065890.1|ensembl:ENSG00000114742(gene)|ensembl:ENST00000302313(transcript)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0003677"(DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043588"(skin development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0072520"(seminiferous tubule development)|go:"GO:1902525"(regulation of protein monoubiquitination)|go:"GO:1903003"(positive regulation of protein deubiquitination)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR021772|interpro:IPR036322|mint:Q8TAF3|rcsb pdb:5CVL|rcsb pdb:5CVN|rcsb pdb:5CVO|rcsb pdb:5K1A|rcsb pdb:5K1B|rcsb pdb:5K1C|rcsb pdb:5L8E|rcsb pdb:5L8W|rcsb pdb:6JLQ|rcsb pdb:7AY0|rcsb pdb:7AY1|rcsb pdb:7AY2|reactome:R-HSA-110314|reactome:R-HSA-5689880|reactome:R-HSA-6783310|reactome:R-HSA-9673766|refseq:NP_001290331.1|refseq:NP_001290332.1|refseq:NP_001333156.1|refseq:NP_001333157.1|dip:DIP-50841N interpro:IPR002501(tRNA pseudouridine synthase B, N-terminal)|interpro:IPR004521(Uncharacterized domain 2)|interpro:IPR004802(Putative rRNA pseudouridine synthase)|interpro:IPR012960(DKCLD)|interpro:IPR015947(PUA-like)|interpro:IPR020103|interpro:IPR032819|interpro:IPR036974|mint:O60832|rcsb pdb:7BGB|reactome:R-HSA-171319|reactome:R-HSA-6790901|interpro:IPR002478(PUA)|ensembl:ENSG00000130826(gene)|ensembl:ENST00000369550(transcript)|go:"GO:0000455"(enzyme-directed rRNA pseudouridine synthesis)|go:"GO:0000495"(box H/ACA RNA 3'-end processing)|go:"GO:0001650"(fibrillar center)|go:"GO:0003720"(telomerase activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006364"(rRNA processing)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0009982"(pseudouridine synthase activity)|go:"GO:0031118"(rRNA pseudouridine synthesis)|go:"GO:0031120"(snRNA pseudouridine synthesis)|go:"GO:0031429"(box H/ACA snoRNP complex)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0034513"(box H/ACA snoRNA binding)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0070034"(telomerase RNA binding)|go:"GO:0072589"(box H/ACA scaRNP complex)|go:"GO:0090661"(box H/ACA telomerase RNP complex)|go:"GO:0090666"(scaRNA localization to Cajal body)|go:"GO:0090669"(telomerase RNA stabilization)|go:"GO:1904851"(positive regulation of establishment of protein localization to telomere)|go:"GO:1904871"(positive regulation of protein localization to Cajal body)|go:"GO:1904872"(regulation of telomerase RNA localization to Cajal body)|go:"GO:1904874"(positive regulation of telomerase RNA localization to Cajal body)|go:"GO:1990481"(mRNA pseudouridine synthesis)|go:"GO:0006396"(RNA processing)|refseq:NP_001354.1|refseq:NP_001135935.1|refseq:NP_001275676.1|dip:DIP-40645N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/05/28 rogid:S8ihl3jxEEyMS46AM2ynXSFfCU49606 rogid:njIdhtX9m37BslwxyAAV/JoRrHo9606 intact-crc:FEA84E4597BF2CAC|rigid:5VpwlpQqzlunHNK7tN6q4Wo+lkI false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8TAF3 uniprotkb:Q9NW82 intact:EBI-1045469|uniprotkb:Q63HJ2|uniprotkb:Q658Y1|uniprotkb:Q8N3Z1|uniprotkb:Q9NSK8|uniprotkb:Q9P279|uniprotkb:B4DM86|uniprotkb:B4DQI2|uniprotkb:B4DY84|ensembl:ENSP00000307491 intact:EBI-2515581|ensembl:ENSP00000265107|uniprotkb:Q9H053 psi-mi:wdr48_human(display_long)|uniprotkb:WD repeat endosomal protein(gene name synonym)|uniprotkb:p80(gene name synonym)|uniprotkb:WDR48(gene name)|psi-mi:WDR48(display_short)|uniprotkb:KIAA1449(gene name synonym)|uniprotkb:UAF1(gene name synonym)|uniprotkb:USP1-associated factor 1(gene name synonym) psi-mi:wdr70_human(display_long)|uniprotkb:WDR70(gene name)|psi-mi:WDR70(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515634|imex:IM-12079-49 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065890.1|ensembl:ENSG00000114742(gene)|ensembl:ENST00000302313(transcript)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0003677"(DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043588"(skin development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0072520"(seminiferous tubule development)|go:"GO:1902525"(regulation of protein monoubiquitination)|go:"GO:1903003"(positive regulation of protein deubiquitination)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR021772|interpro:IPR036322|mint:Q8TAF3|rcsb pdb:5CVL|rcsb pdb:5CVN|rcsb pdb:5CVO|rcsb pdb:5K1A|rcsb pdb:5K1B|rcsb pdb:5K1C|rcsb pdb:5L8E|rcsb pdb:5L8W|rcsb pdb:6JLQ|rcsb pdb:7AY0|rcsb pdb:7AY1|rcsb pdb:7AY2|reactome:R-HSA-110314|reactome:R-HSA-5689880|reactome:R-HSA-6783310|reactome:R-HSA-9673766|refseq:NP_001290331.1|refseq:NP_001290332.1|refseq:NP_001333156.1|refseq:NP_001333157.1|dip:DIP-50841N ensembl:ENSG00000082068(gene)|ensembl:ENST00000265107(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0019899"(enzyme binding)|go:"GO:0035861"(site of double-strand break)|go:"GO:1903775"(regulation of DNA double-strand break processing)|go:"GO:2001173"(regulation of histone H2B conserved C-terminal lysine ubiquitination)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR036322|rcsb pdb:6ZYM|rcsb pdb:7A5P|interpro:IPR001680(WD40 repeat)|refseq:NP_060504.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/05/28 rogid:S8ihl3jxEEyMS46AM2ynXSFfCU49606 rogid:hG9Nbynx50TVtGujhzTLx3dBTKM9606 intact-crc:FEA84E4597BF2CAC|rigid:5VpwlpQqzlunHNK7tN6q4Wo+lkI false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8TAF3 uniprotkb:Q9Y2T2 intact:EBI-1045469|uniprotkb:Q63HJ2|uniprotkb:Q658Y1|uniprotkb:Q8N3Z1|uniprotkb:Q9NSK8|uniprotkb:Q9P279|uniprotkb:B4DM86|uniprotkb:B4DQI2|uniprotkb:B4DY84|ensembl:ENSP00000307491 intact:EBI-2371151|uniprotkb:Q5JQ12|uniprotkb:Q9H5L2|ensembl:ENSP00000347408|ensembl:ENSP00000361831 psi-mi:wdr48_human(display_long)|uniprotkb:WD repeat endosomal protein(gene name synonym)|uniprotkb:p80(gene name synonym)|uniprotkb:WDR48(gene name)|psi-mi:WDR48(display_short)|uniprotkb:KIAA1449(gene name synonym)|uniprotkb:UAF1(gene name synonym)|uniprotkb:USP1-associated factor 1(gene name synonym) psi-mi:ap3m1_human(display_long)|uniprotkb:AP-3 adaptor complex mu3A subunit(gene name synonym)|uniprotkb:Adaptor-related protein complex 3 subunit mu-1(gene name synonym)|uniprotkb:AP3M1(gene name)|psi-mi:AP3M1(display_short)|uniprotkb:Mu-adaptin 3A(gene name synonym)|uniprotkb:Mu3A-adaptin(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515634|imex:IM-12079-49 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065890.1|ensembl:ENSG00000114742(gene)|ensembl:ENST00000302313(transcript)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0003677"(DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043588"(skin development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0072520"(seminiferous tubule development)|go:"GO:1902525"(regulation of protein monoubiquitination)|go:"GO:1903003"(positive regulation of protein deubiquitination)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR021772|interpro:IPR036322|mint:Q8TAF3|rcsb pdb:5CVL|rcsb pdb:5CVN|rcsb pdb:5CVO|rcsb pdb:5K1A|rcsb pdb:5K1B|rcsb pdb:5K1C|rcsb pdb:5L8E|rcsb pdb:5L8W|rcsb pdb:6JLQ|rcsb pdb:7AY0|rcsb pdb:7AY1|rcsb pdb:7AY2|reactome:R-HSA-110314|reactome:R-HSA-5689880|reactome:R-HSA-6783310|reactome:R-HSA-9673766|refseq:NP_001290331.1|refseq:NP_001290332.1|refseq:NP_001333156.1|refseq:NP_001333157.1|dip:DIP-50841N refseq:NP_001307192.1|refseq:NP_001307193.1|refseq:NP_036227.1|refseq:NP_996895.1|ensembl:ENSG00000185009(gene)|ensembl:ENST00000355264(transcript)|ensembl:ENST00000372745(transcript)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006622"(protein targeting to lysosome)|go:"GO:0006897"(endocytosis)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030131"(clathrin adaptor complex)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048490"(anterograde synaptic vesicle transport)|go:"GO:1904115"(axon cytoplasm)|interpro:IPR001392(Clathrin adaptor, mu subunit)|interpro:IPR011012(Longin-like)|interpro:IPR018240|interpro:IPR022775|interpro:IPR028565|interpro:IPR036168|mint:Q9Y2T2|reactome:R-HSA-390471 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/05/28 rogid:S8ihl3jxEEyMS46AM2ynXSFfCU49606 rogid:VsXYkOxEite1RzT1YHCA6/U4gj09606 intact-crc:FEA84E4597BF2CAC|rigid:5VpwlpQqzlunHNK7tN6q4Wo+lkI false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8TAF3 uniprotkb:Q13620 intact:EBI-1045469|uniprotkb:Q63HJ2|uniprotkb:Q658Y1|uniprotkb:Q8N3Z1|uniprotkb:Q9NSK8|uniprotkb:Q9P279|uniprotkb:B4DM86|uniprotkb:B4DQI2|uniprotkb:B4DY84|ensembl:ENSP00000307491 intact:EBI-456067|uniprotkb:Q6PIE4|uniprotkb:Q6UP07|uniprotkb:B3KVX4|uniprotkb:B7Z5K8|uniprotkb:Q7Z673|uniprotkb:Q9BY37|uniprotkb:Q9UEB7|uniprotkb:Q9UED7|uniprotkb:B1APK5|ensembl:ENSP00000505084|ensembl:ENSP00000505176|ensembl:ENSP00000506259 psi-mi:wdr48_human(display_long)|uniprotkb:WD repeat endosomal protein(gene name synonym)|uniprotkb:p80(gene name synonym)|uniprotkb:WDR48(gene name)|psi-mi:WDR48(display_short)|uniprotkb:KIAA1449(gene name synonym)|uniprotkb:UAF1(gene name synonym)|uniprotkb:USP1-associated factor 1(gene name synonym) psi-mi:cul4b_human(display_long)|uniprotkb:CUL4B(gene name)|psi-mi:CUL4B(display_short)|uniprotkb:KIAA0695(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515634|imex:IM-12079-49 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065890.1|ensembl:ENSG00000114742(gene)|ensembl:ENST00000302313(transcript)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0003677"(DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043588"(skin development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0072520"(seminiferous tubule development)|go:"GO:1902525"(regulation of protein monoubiquitination)|go:"GO:1903003"(positive regulation of protein deubiquitination)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR021772|interpro:IPR036322|mint:Q8TAF3|rcsb pdb:5CVL|rcsb pdb:5CVN|rcsb pdb:5CVO|rcsb pdb:5K1A|rcsb pdb:5K1B|rcsb pdb:5K1C|rcsb pdb:5L8E|rcsb pdb:5L8W|rcsb pdb:6JLQ|rcsb pdb:7AY0|rcsb pdb:7AY1|rcsb pdb:7AY2|reactome:R-HSA-110314|reactome:R-HSA-5689880|reactome:R-HSA-6783310|reactome:R-HSA-9673766|refseq:NP_001290331.1|refseq:NP_001290332.1|refseq:NP_001333156.1|refseq:NP_001333157.1|dip:DIP-50841N refseq:NP_001073341.1|refseq:NP_003579.3|ensembl:ENST00000371322|ensembl:ENSP00000360373|ensembl:ENST00000371323|ensembl:ENSP00000360374|ensembl:ENSP00000505084|ensembl:ENSP00000506259|ensembl:ENSP00000505176|refseq:XP_011529702.1|dip:DIP-31609N|ensembl:ENSG00000158290(gene)|ensembl:ENST00000680673(transcript)|ensembl:ENST00000681253(transcript)|ensembl:ENST00000681652(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031175"(neuron projection development)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031465"(Cul4B-RING E3 ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035518"(histone H2A monoubiquitination)|go:"GO:0042254"(ribosome biogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070914"(UV-damage excision repair)|reactome:R-HSA-5696394|reactome:R-HSA-5696395|reactome:R-HSA-5696400|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-8951664|go:"GO:0080008"(Cul4-RING E3 ubiquitin ligase complex)|interpro:IPR001373(Cullin, N-terminal region)|interpro:IPR016157(Cullin, conserved site)|interpro:IPR016158(Cullin homology)|interpro:IPR016159(Cullin repeat-like)|interpro:IPR019559|interpro:IPR033044|interpro:IPR036317|interpro:IPR036388|interpro:IPR036390|mint:Q13620|rcsb pdb:2DO7|rcsb pdb:4A0C|rcsb pdb:4A0L|rcsb pdb:4A64|reactome:R-HSA-110314 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/05/28 rogid:S8ihl3jxEEyMS46AM2ynXSFfCU49606 rogid:D75aMBt3GaBdpBt5Mxsxk7yiRVg9606 intact-crc:FEA84E4597BF2CAC|rigid:5VpwlpQqzlunHNK7tN6q4Wo+lkI false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8TAF3 uniprotkb:Q9UID6 intact:EBI-1045469|uniprotkb:Q63HJ2|uniprotkb:Q658Y1|uniprotkb:Q8N3Z1|uniprotkb:Q9NSK8|uniprotkb:Q9P279|uniprotkb:B4DM86|uniprotkb:B4DQI2|uniprotkb:B4DY84|ensembl:ENSP00000307491 intact:EBI-947476|uniprotkb:A9X3Z9|intact:EBI-3451660|uniprotkb:D3DNR3|ensembl:ENSP00000325634|ensembl:ENSP00000417740|ensembl:ENSP00000418766|ensembl:ENSP00000477626 psi-mi:wdr48_human(display_long)|uniprotkb:WD repeat endosomal protein(gene name synonym)|uniprotkb:p80(gene name synonym)|uniprotkb:WDR48(gene name)|psi-mi:WDR48(display_short)|uniprotkb:KIAA1449(gene name synonym)|uniprotkb:UAF1(gene name synonym)|uniprotkb:USP1-associated factor 1(gene name synonym) psi-mi:zn639_human(display_long)|uniprotkb:ZNF639(gene name)|psi-mi:ZNF639(display_short)|uniprotkb:ZASC1(gene name synonym)|uniprotkb:Zinc finger protein ZASC1(gene name synonym)|uniprotkb:Zinc finger protein ANC_2H01(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515634|imex:IM-12079-49 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065890.1|ensembl:ENSG00000114742(gene)|ensembl:ENST00000302313(transcript)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0003677"(DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043588"(skin development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0072520"(seminiferous tubule development)|go:"GO:1902525"(regulation of protein monoubiquitination)|go:"GO:1903003"(positive regulation of protein deubiquitination)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR021772|interpro:IPR036322|mint:Q8TAF3|rcsb pdb:5CVL|rcsb pdb:5CVN|rcsb pdb:5CVO|rcsb pdb:5K1A|rcsb pdb:5K1B|rcsb pdb:5K1C|rcsb pdb:5L8E|rcsb pdb:5L8W|rcsb pdb:6JLQ|rcsb pdb:7AY0|rcsb pdb:7AY1|rcsb pdb:7AY2|reactome:R-HSA-110314|reactome:R-HSA-5689880|reactome:R-HSA-6783310|reactome:R-HSA-9673766|refseq:NP_001290331.1|refseq:NP_001290332.1|refseq:NP_001333156.1|refseq:NP_001333157.1|dip:DIP-50841N refseq:NP_057415.1|refseq:NP_001290354.1|refseq:NP_001290355.1|refseq:XP_016862039.1|refseq:XP_016862040.1|refseq:XP_016862041.1|refseq:XP_016862042.1|ensembl:ENSG00000121864(gene)|ensembl:ENST00000326361(transcript)|ensembl:ENST00000484866(transcript)|ensembl:ENST00000496856(transcript)|ensembl:ENST00000621687(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0043621"(protein self-association)|go:"GO:0043922"(negative regulation by host of viral transcription)|go:"GO:0043923"(positive regulation by host of viral transcription)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046872"(metal ion binding)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/05/28 rogid:S8ihl3jxEEyMS46AM2ynXSFfCU49606 rogid:hqDnNdTVsE4aB6PRCryUV02vtGg9606 intact-crc:FEA84E4597BF2CAC|rigid:5VpwlpQqzlunHNK7tN6q4Wo+lkI false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8TAF3 uniprotkb:Q13428 intact:EBI-1045469|uniprotkb:Q63HJ2|uniprotkb:Q658Y1|uniprotkb:Q8N3Z1|uniprotkb:Q9NSK8|uniprotkb:Q9P279|uniprotkb:B4DM86|uniprotkb:B4DQI2|uniprotkb:B4DY84|ensembl:ENSP00000307491 intact:EBI-396105|uniprotkb:Q6SC72|uniprotkb:Q7Z5W9|uniprotkb:Q96A52|uniprotkb:Q99408|uniprotkb:Q99860|uniprotkb:A0JLU0|uniprotkb:B4E111|intact:EBI-28974716|ensembl:ENSP00000367028|ensembl:ENSP00000421655 psi-mi:wdr48_human(display_long)|uniprotkb:WD repeat endosomal protein(gene name synonym)|uniprotkb:p80(gene name synonym)|uniprotkb:WDR48(gene name)|psi-mi:WDR48(display_short)|uniprotkb:KIAA1449(gene name synonym)|uniprotkb:UAF1(gene name synonym)|uniprotkb:USP1-associated factor 1(gene name synonym) psi-mi:tcof_human(display_long)|uniprotkb:TCOF1(gene name)|psi-mi:TCOF1(display_short)|uniprotkb:Treacher Collins syndrome protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515634|imex:IM-12079-49 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065890.1|ensembl:ENSG00000114742(gene)|ensembl:ENST00000302313(transcript)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0003677"(DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043588"(skin development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0072520"(seminiferous tubule development)|go:"GO:1902525"(regulation of protein monoubiquitination)|go:"GO:1903003"(positive regulation of protein deubiquitination)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR021772|interpro:IPR036322|mint:Q8TAF3|rcsb pdb:5CVL|rcsb pdb:5CVN|rcsb pdb:5CVO|rcsb pdb:5K1A|rcsb pdb:5K1B|rcsb pdb:5K1C|rcsb pdb:5L8E|rcsb pdb:5L8W|rcsb pdb:6JLQ|rcsb pdb:7AY0|rcsb pdb:7AY1|rcsb pdb:7AY2|reactome:R-HSA-110314|reactome:R-HSA-5689880|reactome:R-HSA-6783310|reactome:R-HSA-9673766|refseq:NP_001290331.1|refseq:NP_001290332.1|refseq:NP_001333156.1|refseq:NP_001333157.1|dip:DIP-50841N refseq:NP_000347.2|refseq:NP_001008657.1|refseq:NP_001128715.1|refseq:NP_001128716.1|refseq:NP_001128717.1|refseq:NP_001182070.1|ensembl:ENST00000323668|ensembl:ENSP00000325223|ensembl:ENSP00000367028|ensembl:ENST00000394269|ensembl:ENSP00000377811|ensembl:ENST00000427724|ensembl:ENSP00000390717|ensembl:ENST00000439160|ensembl:ENSP00000406888|ensembl:ENST00000445265|ensembl:ENSP00000409944|ensembl:ENSP00000421655|ensembl:ENST00000643257|ensembl:ENSP00000493815|refseq:XP_005268562.1|ensembl:ENSG00000070814(gene)|ensembl:ENST00000377797(transcript)|ensembl:ENST00000504761(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001650"(fibrillar center)|go:"GO:0003723"(RNA binding)|go:"GO:0005215"(transporter activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006417"(regulation of translation)|go:"GO:0014029"(neural crest formation)|go:"GO:0014032"(neural crest cell development)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0042790"(nucleolar large rRNA transcription by RNA polymerase I)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0097110"(scaffold protein binding)|interpro:IPR003993(Treacher Collins syndrome, treacle)|interpro:IPR006594(LisH dimerisation motif)|interpro:IPR017859|mint:Q13428|dip:DIP-32953N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/05/28 rogid:S8ihl3jxEEyMS46AM2ynXSFfCU49606 rogid:eRazgHpn5CwQVFH5hRnA/sVp24M9606 intact-crc:FEA84E4597BF2CAC|rigid:5VpwlpQqzlunHNK7tN6q4Wo+lkI false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8TAF3 uniprotkb:Q14137 intact:EBI-1045469|uniprotkb:Q63HJ2|uniprotkb:Q658Y1|uniprotkb:Q8N3Z1|uniprotkb:Q9NSK8|uniprotkb:Q9P279|uniprotkb:B4DM86|uniprotkb:B4DQI2|uniprotkb:B4DY84|ensembl:ENSP00000307491 intact:EBI-1050828|uniprotkb:Q969Z6|uniprotkb:Q96IS8|uniprotkb:Q9BSA7|uniprotkb:Q9BVM0|ensembl:ENSP00000455106|ensembl:ENSP00000495401|uniprotkb:Q96Q25 psi-mi:wdr48_human(display_long)|uniprotkb:WD repeat endosomal protein(gene name synonym)|uniprotkb:p80(gene name synonym)|uniprotkb:WDR48(gene name)|psi-mi:WDR48(display_short)|uniprotkb:KIAA1449(gene name synonym)|uniprotkb:UAF1(gene name synonym)|uniprotkb:USP1-associated factor 1(gene name synonym) psi-mi:bop1_human(display_long)|uniprotkb:Block of proliferation 1 protein(gene name synonym)|uniprotkb:BOP1(gene name)|psi-mi:BOP1(display_short)|uniprotkb:KIAA0124(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515634|imex:IM-12079-49 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065890.1|ensembl:ENSG00000114742(gene)|ensembl:ENST00000302313(transcript)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0003677"(DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043588"(skin development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0072520"(seminiferous tubule development)|go:"GO:1902525"(regulation of protein monoubiquitination)|go:"GO:1903003"(positive regulation of protein deubiquitination)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR021772|interpro:IPR036322|mint:Q8TAF3|rcsb pdb:5CVL|rcsb pdb:5CVN|rcsb pdb:5CVO|rcsb pdb:5K1A|rcsb pdb:5K1B|rcsb pdb:5K1C|rcsb pdb:5L8E|rcsb pdb:5L8W|rcsb pdb:6JLQ|rcsb pdb:7AY0|rcsb pdb:7AY1|rcsb pdb:7AY2|reactome:R-HSA-110314|reactome:R-HSA-5689880|reactome:R-HSA-6783310|reactome:R-HSA-9673766|refseq:NP_001290331.1|refseq:NP_001290332.1|refseq:NP_001333156.1|refseq:NP_001333157.1|dip:DIP-50841N refseq:NP_056016.1|ensembl:ENSG00000261236(gene)|ensembl:ENSG00000285301(gene)|ensembl:ENST00000569669(transcript)|ensembl:ENST00000642409(transcript)|go:"GO:0000027"(ribosomal large subunit assembly)|go:"GO:0000448"("cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0000463"("maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0008283"(cell population proliferation)|go:"GO:0030687"(preribosome, large subunit precursor)|go:"GO:0042254"(ribosome biogenesis)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070545"(PeBoW complex)|go:"GO:1901796"(regulation of signal transduction by p53 class mediator)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR001680(WD40 repeat)|interpro:IPR012953(BOP1, N-terminal)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR028598|interpro:IPR036322|mint:Q14137|reactome:R-HSA-6791226 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/05/28 rogid:S8ihl3jxEEyMS46AM2ynXSFfCU49606 rogid:g2CwsRotXBvjvr+rSZSA0mKrVCY9606 intact-crc:FEA84E4597BF2CAC|rigid:5VpwlpQqzlunHNK7tN6q4Wo+lkI false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8TAF3 uniprotkb:Q14152 intact:EBI-1045469|uniprotkb:Q63HJ2|uniprotkb:Q658Y1|uniprotkb:Q8N3Z1|uniprotkb:Q9NSK8|uniprotkb:Q9P279|uniprotkb:B4DM86|uniprotkb:B4DQI2|uniprotkb:B4DY84|ensembl:ENSP00000307491 intact:EBI-366617|uniprotkb:O00653|uniprotkb:Q15778|uniprotkb:B1AMV5|intact:EBI-28978176|ensembl:ENSP00000358140|ensembl:ENSP00000438178|uniprotkb:B4DYS1|uniprotkb:F5H335 psi-mi:wdr48_human(display_long)|uniprotkb:WD repeat endosomal protein(gene name synonym)|uniprotkb:p80(gene name synonym)|uniprotkb:WDR48(gene name)|psi-mi:WDR48(display_short)|uniprotkb:KIAA1449(gene name synonym)|uniprotkb:UAF1(gene name synonym)|uniprotkb:USP1-associated factor 1(gene name synonym) psi-mi:eif3a_human(display_long)|uniprotkb:EIF3A(gene name)|psi-mi:EIF3A(display_short)|uniprotkb:KIAA0139(gene name synonym)|uniprotkb:EIF3S10(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 10(gene name synonym)|uniprotkb:eIF-3-theta(gene name synonym)|uniprotkb:eIF3 p167(gene name synonym)|uniprotkb:eIF3 p180(gene name synonym)|uniprotkb:eIF3 p185(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515634|imex:IM-12079-49 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065890.1|ensembl:ENSG00000114742(gene)|ensembl:ENST00000302313(transcript)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0003677"(DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043588"(skin development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0072520"(seminiferous tubule development)|go:"GO:1902525"(regulation of protein monoubiquitination)|go:"GO:1903003"(positive regulation of protein deubiquitination)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR021772|interpro:IPR036322|mint:Q8TAF3|rcsb pdb:5CVL|rcsb pdb:5CVN|rcsb pdb:5CVO|rcsb pdb:5K1A|rcsb pdb:5K1B|rcsb pdb:5K1C|rcsb pdb:5L8E|rcsb pdb:5L8W|rcsb pdb:6JLQ|rcsb pdb:7AY0|rcsb pdb:7AY1|rcsb pdb:7AY2|reactome:R-HSA-110314|reactome:R-HSA-5689880|reactome:R-HSA-6783310|reactome:R-HSA-9673766|refseq:NP_001290331.1|refseq:NP_001290332.1|refseq:NP_001333156.1|refseq:NP_001333157.1|dip:DIP-50841N refseq:NP_003741.1|ensembl:ENSP00000358140|ensembl:ENSP00000438178|ensembl:ENSG00000107581(gene)|ensembl:ENST00000369144(transcript)|ensembl:ENST00000541549(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0002188"(translation reinitiation)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0005874"(microtubule)|go:"GO:0006413"(translational initiation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0043614"(multi-eIF complex)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071540"(eukaryotic translation initiation factor 3 complex, eIF3e)|go:"GO:0071541"(eukaryotic translation initiation factor 3 complex, eIF3m)|go:"GO:0075522"(IRES-dependent viral translational initiation)|go:"GO:0075525"(viral translational termination-reinitiation)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR027512|mint:Q14152|rcsb pdb:3J8B|rcsb pdb:3J8C|rcsb pdb:6YBD|rcsb pdb:6YBT|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|dip:DIP-31114N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/05/28 rogid:S8ihl3jxEEyMS46AM2ynXSFfCU49606 rogid:COyPBU7e0SUL3BiZY7NQuUkmxns9606 intact-crc:FEA84E4597BF2CAC|rigid:5VpwlpQqzlunHNK7tN6q4Wo+lkI false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8TAF3 uniprotkb:Q9NPE3 intact:EBI-1045469|uniprotkb:Q63HJ2|uniprotkb:Q658Y1|uniprotkb:Q8N3Z1|uniprotkb:Q9NSK8|uniprotkb:Q9P279|uniprotkb:B4DM86|uniprotkb:B4DQI2|uniprotkb:B4DY84|ensembl:ENSP00000307491 intact:EBI-1642169|ensembl:ENSP00000332198 psi-mi:wdr48_human(display_long)|uniprotkb:WD repeat endosomal protein(gene name synonym)|uniprotkb:p80(gene name synonym)|uniprotkb:WDR48(gene name)|psi-mi:WDR48(display_short)|uniprotkb:KIAA1449(gene name synonym)|uniprotkb:UAF1(gene name synonym)|uniprotkb:USP1-associated factor 1(gene name synonym) psi-mi:nop10_human(display_long)|uniprotkb:NOLA3(gene name synonym)|uniprotkb:NOP10(gene name)|psi-mi:NOP10(display_short)|uniprotkb:Nucleolar protein family A member 3(gene name synonym)|uniprotkb:snoRNP protein NOP10(gene name synonym)|uniprotkb:Nucleolar protein 10(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515634|imex:IM-12079-49 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065890.1|ensembl:ENSG00000114742(gene)|ensembl:ENST00000302313(transcript)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0003677"(DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043588"(skin development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0072520"(seminiferous tubule development)|go:"GO:1902525"(regulation of protein monoubiquitination)|go:"GO:1903003"(positive regulation of protein deubiquitination)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR021772|interpro:IPR036322|mint:Q8TAF3|rcsb pdb:5CVL|rcsb pdb:5CVN|rcsb pdb:5CVO|rcsb pdb:5K1A|rcsb pdb:5K1B|rcsb pdb:5K1C|rcsb pdb:5L8E|rcsb pdb:5L8W|rcsb pdb:6JLQ|rcsb pdb:7AY0|rcsb pdb:7AY1|rcsb pdb:7AY2|reactome:R-HSA-110314|reactome:R-HSA-5689880|reactome:R-HSA-6783310|reactome:R-HSA-9673766|refseq:NP_001290331.1|refseq:NP_001290332.1|refseq:NP_001333156.1|refseq:NP_001333157.1|dip:DIP-50841N refseq:NP_061118.1|dip:DIP-40092N|ensembl:ENSG00000182117(gene)|ensembl:ENST00000328848(transcript)|go:"GO:0000454"(snoRNA guided rRNA pseudouridine synthesis)|go:"GO:0001522"(pseudouridine synthesis)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0005732"("sno(s)RNA-containing ribonucleoprotein complex")|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0016604"(nuclear body)|go:"GO:0031118"(rRNA pseudouridine synthesis)|go:"GO:0031120"(snRNA pseudouridine synthesis)|go:"GO:0031429"(box H/ACA snoRNP complex)|go:"GO:0034513"(box H/ACA snoRNA binding)|go:"GO:0070034"(telomerase RNA binding)|go:"GO:0072589"(box H/ACA scaRNP complex)|go:"GO:0090661"(box H/ACA telomerase RNP complex)|go:"GO:1904874"(positive regulation of telomerase RNA localization to Cajal body)|interpro:IPR007264(Nucleolar RNA-binding protein Nop10p)|interpro:IPR036756|mint:Q9NPE3|rcsb pdb:7BGB|reactome:R-HSA-171319|reactome:R-HSA-6790901 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/05/28 rogid:S8ihl3jxEEyMS46AM2ynXSFfCU49606 rogid:gBAwyGcfJTBMf8Q+fQZ/fDcPEBc9606 intact-crc:FEA84E4597BF2CAC|rigid:5VpwlpQqzlunHNK7tN6q4Wo+lkI false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8TAF3 uniprotkb:O15372 intact:EBI-1045469|uniprotkb:Q63HJ2|uniprotkb:Q658Y1|uniprotkb:Q8N3Z1|uniprotkb:Q9NSK8|uniprotkb:Q9P279|uniprotkb:B4DM86|uniprotkb:B4DQI2|uniprotkb:B4DY84|ensembl:ENSP00000307491 intact:EBI-709735|ensembl:ENSP00000429931 psi-mi:wdr48_human(display_long)|uniprotkb:WD repeat endosomal protein(gene name synonym)|uniprotkb:p80(gene name synonym)|uniprotkb:WDR48(gene name)|psi-mi:WDR48(display_short)|uniprotkb:KIAA1449(gene name synonym)|uniprotkb:UAF1(gene name synonym)|uniprotkb:USP1-associated factor 1(gene name synonym) psi-mi:eif3h_human(display_long)|uniprotkb:EIF3S3(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 3(gene name synonym)|uniprotkb:eIF-3-gamma(gene name synonym)|uniprotkb:eIF3 p40 subunit(gene name synonym)|uniprotkb:EIF3H(gene name)|psi-mi:EIF3H(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515634|imex:IM-12079-49 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065890.1|ensembl:ENSG00000114742(gene)|ensembl:ENST00000302313(transcript)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0003677"(DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043588"(skin development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0072520"(seminiferous tubule development)|go:"GO:1902525"(regulation of protein monoubiquitination)|go:"GO:1903003"(positive regulation of protein deubiquitination)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR021772|interpro:IPR036322|mint:Q8TAF3|rcsb pdb:5CVL|rcsb pdb:5CVN|rcsb pdb:5CVO|rcsb pdb:5K1A|rcsb pdb:5K1B|rcsb pdb:5K1C|rcsb pdb:5L8E|rcsb pdb:5L8W|rcsb pdb:6JLQ|rcsb pdb:7AY0|rcsb pdb:7AY1|rcsb pdb:7AY2|reactome:R-HSA-110314|reactome:R-HSA-5689880|reactome:R-HSA-6783310|reactome:R-HSA-9673766|refseq:NP_001290331.1|refseq:NP_001290332.1|refseq:NP_001333156.1|refseq:NP_001333157.1|dip:DIP-50841N refseq:NP_003747.1|ensembl:ENSG00000147677(gene)|ensembl:ENST00000521861(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0016020"(membrane)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070122"(isopeptidase activity)|go:"GO:0071541"(eukaryotic translation initiation factor 3 complex, eIF3m)|go:"GO:0101005"(deubiquitinase activity)|interpro:IPR000555(Mov34/MPN/PAD-1)|interpro:IPR027524|interpro:IPR037518|mint:O15372|rcsb pdb:3J8B|rcsb pdb:3J8C|rcsb pdb:6YBD|rcsb pdb:6ZMW|rcsb pdb:6ZON|rcsb pdb:6ZP4|rcsb pdb:6ZVJ|rcsb pdb:7A09|reactome:R-HSA-156827|reactome:R-HSA-72649|reactome:R-HSA-72689|reactome:R-HSA-72695|reactome:R-HSA-72702|reactome:R-HSA-72706|dip:DIP-33689N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/05/28 rogid:S8ihl3jxEEyMS46AM2ynXSFfCU49606 rogid:p1S78JRQsXwUzzAJkG02ABVWTNs9606 intact-crc:FEA84E4597BF2CAC|rigid:5VpwlpQqzlunHNK7tN6q4Wo+lkI false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8TAF3 uniprotkb:O95071 intact:EBI-1045469|uniprotkb:Q63HJ2|uniprotkb:Q658Y1|uniprotkb:Q8N3Z1|uniprotkb:Q9NSK8|uniprotkb:Q9P279|uniprotkb:B4DM86|uniprotkb:B4DQI2|uniprotkb:B4DY84|ensembl:ENSP00000307491 intact:EBI-358329|uniprotkb:O94970|uniprotkb:Q9NPL3|ensembl:ENSP00000429084|uniprotkb:B2RP24|intact:EBI-10967451|uniprotkb:J3KMW7 psi-mi:wdr48_human(display_long)|uniprotkb:WD repeat endosomal protein(gene name synonym)|uniprotkb:p80(gene name synonym)|uniprotkb:WDR48(gene name)|psi-mi:WDR48(display_short)|uniprotkb:KIAA1449(gene name synonym)|uniprotkb:UAF1(gene name synonym)|uniprotkb:USP1-associated factor 1(gene name synonym) psi-mi:ubr5_human(display_long)|uniprotkb:UBR5(gene name)|psi-mi:UBR5(display_short)|uniprotkb:HYD(gene name synonym)|uniprotkb:KIAA0896(gene name synonym)|uniprotkb:EDD(gene name synonym)|uniprotkb:EDD1(gene name synonym)|uniprotkb:E3 ubiquitin-protein ligase, HECT domain-containing 1(gene name synonym)|uniprotkb:Hyperplastic discs protein homolog(gene name synonym)|uniprotkb:Progestin-induced protein(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase UBR5(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515634|imex:IM-12079-49 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065890.1|ensembl:ENSG00000114742(gene)|ensembl:ENST00000302313(transcript)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0003677"(DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043588"(skin development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0072520"(seminiferous tubule development)|go:"GO:1902525"(regulation of protein monoubiquitination)|go:"GO:1903003"(positive regulation of protein deubiquitination)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR021772|interpro:IPR036322|mint:Q8TAF3|rcsb pdb:5CVL|rcsb pdb:5CVN|rcsb pdb:5CVO|rcsb pdb:5K1A|rcsb pdb:5K1B|rcsb pdb:5K1C|rcsb pdb:5L8E|rcsb pdb:5L8W|rcsb pdb:6JLQ|rcsb pdb:7AY0|rcsb pdb:7AY1|rcsb pdb:7AY2|reactome:R-HSA-110314|reactome:R-HSA-5689880|reactome:R-HSA-6783310|reactome:R-HSA-9673766|refseq:NP_001290331.1|refseq:NP_001290332.1|refseq:NP_001333156.1|refseq:NP_001333157.1|dip:DIP-50841N refseq:NP_001269802.1|ensembl:ENST00000520539(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034450"(ubiquitin-ubiquitin ligase activity)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050847"(progesterone receptor signaling pathway)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1901315"(negative regulation of histone H2A K63-linked ubiquitination)|ensembl:ENSG00000104517(gene)|go:"GO:2000779"(regulation of double-strand break repair)|go:"GO:2000780"(negative regulation of double-strand break repair)|interpro:IPR000569(HECT)|interpro:IPR002004(Polyadenylate-binding protein/Hyperplastic disc protein)|interpro:IPR003126(Zinc finger, N-recognin)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|interpro:IPR024725|interpro:IPR035983|interpro:IPR036053|mint:O95071|rcsb pdb:1I2T|rcsb pdb:2QHO|refseq:NP_056986.2|rcsb pdb:3PT3|dip:DIP-32930N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/05/28 rogid:S8ihl3jxEEyMS46AM2ynXSFfCU49606 rogid:5yiXAYJbV4iA8d3btwaVfL7vaik9606 intact-crc:FEA84E4597BF2CAC|rigid:5VpwlpQqzlunHNK7tN6q4Wo+lkI false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8TAF3 uniprotkb:Q96HN2 intact:EBI-1045469|uniprotkb:Q63HJ2|uniprotkb:Q658Y1|uniprotkb:Q8N3Z1|uniprotkb:Q9NSK8|uniprotkb:Q9P279|uniprotkb:B4DM86|uniprotkb:B4DQI2|uniprotkb:B4DY84|ensembl:ENSP00000307491 intact:EBI-1056923|uniprotkb:O94917|uniprotkb:B4DIZ5|uniprotkb:D9N155|ensembl:ENSP00000315931 psi-mi:wdr48_human(display_long)|uniprotkb:WD repeat endosomal protein(gene name synonym)|uniprotkb:p80(gene name synonym)|uniprotkb:WDR48(gene name)|psi-mi:WDR48(display_short)|uniprotkb:KIAA1449(gene name synonym)|uniprotkb:UAF1(gene name synonym)|uniprotkb:USP1-associated factor 1(gene name synonym) psi-mi:sahh3_human(display_long)|uniprotkb:AHCYL2(gene name)|psi-mi:AHCYL2(display_short)|uniprotkb:KIAA0828(gene name synonym)|uniprotkb:S-adenosyl-L-homocysteine hydrolase 3(gene name synonym)|uniprotkb:S-adenosylhomocysteine hydrolase-like protein 2(gene name synonym)|uniprotkb:"IP(3)Rs binding protein released with IP(3) 2"(gene name synonym)|uniprotkb:Long-IRBIT(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515634|imex:IM-12079-49 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065890.1|ensembl:ENSG00000114742(gene)|ensembl:ENST00000302313(transcript)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0003677"(DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043588"(skin development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0072520"(seminiferous tubule development)|go:"GO:1902525"(regulation of protein monoubiquitination)|go:"GO:1903003"(positive regulation of protein deubiquitination)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR021772|interpro:IPR036322|mint:Q8TAF3|rcsb pdb:5CVL|rcsb pdb:5CVN|rcsb pdb:5CVO|rcsb pdb:5K1A|rcsb pdb:5K1B|rcsb pdb:5K1C|rcsb pdb:5L8E|rcsb pdb:5L8W|rcsb pdb:6JLQ|rcsb pdb:7AY0|rcsb pdb:7AY1|rcsb pdb:7AY2|reactome:R-HSA-110314|reactome:R-HSA-5689880|reactome:R-HSA-6783310|reactome:R-HSA-9673766|refseq:NP_001290331.1|refseq:NP_001290332.1|refseq:NP_001333156.1|refseq:NP_001333157.1|dip:DIP-50841N refseq:NP_001124192.1|refseq:NP_001124194.2|refseq:NP_001124195.1|refseq:NP_056143.1|ensembl:ENSG00000158467(gene)|ensembl:ENST00000325006(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006730"(one-carbon metabolic process)|go:"GO:0016787"(hydrolase activity)|go:"GO:0033353"(S-adenosylmethionine cycle)|go:"GO:0043005"(neuron projection)|interpro:IPR000043(S-adenosyl-L-homocysteine hydrolase)|interpro:IPR015878(S-adenosyl-L-homocysteine hydrolase, NAD binding)|interpro:IPR020082|interpro:IPR036291|interpro:IPR042172|rcsb pdb:3GVP|reactome:R-HSA-425381 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/05/28 rogid:S8ihl3jxEEyMS46AM2ynXSFfCU49606 rogid:OOrDmlSeGOWqnAhYQcNa4tF5pk09606 intact-crc:FEA84E4597BF2CAC|rigid:5VpwlpQqzlunHNK7tN6q4Wo+lkI false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8TAF3 uniprotkb:P62487 intact:EBI-1045469|uniprotkb:Q63HJ2|uniprotkb:Q658Y1|uniprotkb:Q8N3Z1|uniprotkb:Q9NSK8|uniprotkb:Q9P279|uniprotkb:B4DM86|uniprotkb:B4DQI2|uniprotkb:B4DY84|ensembl:ENSP00000307491 intact:EBI-347928|ensembl:ENSP00000301788|uniprotkb:P52433|uniprotkb:Q2M1Z4|uniprotkb:B2R5C0 psi-mi:wdr48_human(display_long)|uniprotkb:WD repeat endosomal protein(gene name synonym)|uniprotkb:p80(gene name synonym)|uniprotkb:WDR48(gene name)|psi-mi:WDR48(display_short)|uniprotkb:KIAA1449(gene name synonym)|uniprotkb:UAF1(gene name synonym)|uniprotkb:USP1-associated factor 1(gene name synonym) psi-mi:rpb7_human(display_long)|uniprotkb:POLR2G(gene name)|psi-mi:POLR2G(display_short)|uniprotkb:DNA-directed RNA polymerase II subunit G(gene name synonym)|uniprotkb:RPB7(gene name synonym)|uniprotkb:RNA polymerase II 19 kDa subunit(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515634|imex:IM-12079-49 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065890.1|ensembl:ENSG00000114742(gene)|ensembl:ENST00000302313(transcript)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0003677"(DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043588"(skin development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0072520"(seminiferous tubule development)|go:"GO:1902525"(regulation of protein monoubiquitination)|go:"GO:1903003"(positive regulation of protein deubiquitination)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR021772|interpro:IPR036322|mint:Q8TAF3|rcsb pdb:5CVL|rcsb pdb:5CVN|rcsb pdb:5CVO|rcsb pdb:5K1A|rcsb pdb:5K1B|rcsb pdb:5K1C|rcsb pdb:5L8E|rcsb pdb:5L8W|rcsb pdb:6JLQ|rcsb pdb:7AY0|rcsb pdb:7AY1|rcsb pdb:7AY2|reactome:R-HSA-110314|reactome:R-HSA-5689880|reactome:R-HSA-6783310|reactome:R-HSA-9673766|refseq:NP_001290331.1|refseq:NP_001290332.1|refseq:NP_001333156.1|refseq:NP_001333157.1|dip:DIP-50841N ensembl:ENSG00000168002(gene)|ensembl:ENST00000301788(transcript)|go:"GO:0000291"(nuclear-transcribed mRNA catabolic process, exonucleolytic)|go:"GO:0000932"(P-body)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0003899"(DNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005665"(RNA polymerase II, core complex)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0006915"(apoptotic process)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0060213"("positive regulation of nuclear-transcribed mRNA poly(A) tail shortening")|interpro:IPR003029(S1, RNA binding)|interpro:IPR005576(RNA polymerase Rpb7, N-terminal)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR022967|interpro:IPR036898|mint:P62487|rcsb pdb:2C35|rcsb pdb:5IYA|rcsb pdb:5IY6|rcsb pdb:5IYB|rcsb pdb:5IYC|rcsb pdb:5IYD|rcsb pdb:6DRD|rcsb pdb:6O9L|rcsb pdb:6XRE|rcsb pdb:7LBM|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167160|reactome:R-HSA-167161|reactome:R-HSA-167162|reactome:R-HSA-167172|rcsb pdb:5IY7|reactome:R-HSA-167200|reactome:R-HSA-167238|rcsb pdb:5IY8|rcsb pdb:5IY9|reactome:R-HSA-167242|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-168325|reactome:R-HSA-203927|reactome:R-HSA-5578749|reactome:R-HSA-5617472|reactome:R-HSA-674695|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6796648|reactome:R-HSA-6803529|reactome:R-HSA-6807505|reactome:R-HSA-72086|reactome:R-HSA-72163|reactome:R-HSA-72165|reactome:R-HSA-72203|reactome:R-HSA-73776|reactome:R-HSA-73779|reactome:R-HSA-5601884|reactome:R-HSA-75953|reactome:R-HSA-75955|reactome:R-HSA-76042|reactome:R-HSA-77075|reactome:R-HSA-8851708|reactome:R-HSA-9018519|reactome:R-HSA-9670095|refseq:NP_002687.1|dip:DIP-32663N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/05/28 rogid:S8ihl3jxEEyMS46AM2ynXSFfCU49606 rogid:MtnIweuhSqLFov0c40uOiwv8Eas9606 intact-crc:FEA84E4597BF2CAC|rigid:5VpwlpQqzlunHNK7tN6q4Wo+lkI false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8TAF3 uniprotkb:O15013 intact:EBI-1045469|uniprotkb:Q63HJ2|uniprotkb:Q658Y1|uniprotkb:Q8N3Z1|uniprotkb:Q9NSK8|uniprotkb:Q9P279|uniprotkb:B4DM86|uniprotkb:B4DQI2|uniprotkb:B4DY84|ensembl:ENSP00000307491 intact:EBI-2515636|uniprotkb:Q2KHR8|uniprotkb:Q8IY77|uniprotkb:Q68D55|uniprotkb:O14665|uniprotkb:Q8IWD9|ensembl:ENSP00000381571|ensembl:ENSP00000481974 psi-mi:wdr48_human(display_long)|uniprotkb:WD repeat endosomal protein(gene name synonym)|uniprotkb:p80(gene name synonym)|uniprotkb:WDR48(gene name)|psi-mi:WDR48(display_short)|uniprotkb:KIAA1449(gene name synonym)|uniprotkb:UAF1(gene name synonym)|uniprotkb:USP1-associated factor 1(gene name synonym) psi-mi:arhga_human(display_long)|uniprotkb:ARHGEF10(gene name)|psi-mi:ARHGEF10(display_short)|uniprotkb:KIAA0294(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515634|imex:IM-12079-49 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065890.1|ensembl:ENSG00000114742(gene)|ensembl:ENST00000302313(transcript)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0003677"(DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043588"(skin development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0072520"(seminiferous tubule development)|go:"GO:1902525"(regulation of protein monoubiquitination)|go:"GO:1903003"(positive regulation of protein deubiquitination)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR021772|interpro:IPR036322|mint:Q8TAF3|rcsb pdb:5CVL|rcsb pdb:5CVN|rcsb pdb:5CVO|rcsb pdb:5K1A|rcsb pdb:5K1B|rcsb pdb:5K1C|rcsb pdb:5L8E|rcsb pdb:5L8W|rcsb pdb:6JLQ|rcsb pdb:7AY0|rcsb pdb:7AY1|rcsb pdb:7AY2|reactome:R-HSA-110314|reactome:R-HSA-5689880|reactome:R-HSA-6783310|reactome:R-HSA-9673766|refseq:NP_001290331.1|refseq:NP_001290332.1|refseq:NP_001333156.1|refseq:NP_001333157.1|dip:DIP-50841N refseq:NP_001295081.1|refseq:NP_001295082.1|refseq:XP_016869492.1|refseq:NP_055444.2|ensembl:ENSG00000104728(gene)|ensembl:ENSG00000274726(gene)|ensembl:ENST00000398564(transcript)|ensembl:ENST00000610399(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0022011"(myelination in peripheral nervous system)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0051298"(centrosome duplication)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:0090630"(activation of GTPase activity)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR030632|interpro:IPR035899|interpro:IPR036322|interpro:IPR039919|reactome:R-HSA-193648|reactome:R-HSA-416482|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|go:"GO:0019894"(kinesin binding) psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/05/28 rogid:S8ihl3jxEEyMS46AM2ynXSFfCU49606 rogid:ItJsuYi6vx3O1aAzi4Jz1OXS2hI9606 intact-crc:FEA84E4597BF2CAC|rigid:5VpwlpQqzlunHNK7tN6q4Wo+lkI false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8TAF3 uniprotkb:O60346 intact:EBI-1045469|uniprotkb:Q63HJ2|uniprotkb:Q658Y1|uniprotkb:Q8N3Z1|uniprotkb:Q9NSK8|uniprotkb:Q9P279|uniprotkb:B4DM86|uniprotkb:B4DQI2|uniprotkb:B4DY84|ensembl:ENSP00000307491 intact:EBI-2511516|intact:EBI-28974360|ensembl:ENSP00000262719|uniprotkb:Q6PJI6|uniprotkb:Q6P4C4|uniprotkb:A1A4F5|uniprotkb:Q641Q7|uniprotkb:Q86TN6|uniprotkb:Q96FK2|uniprotkb:Q9NUY1 psi-mi:wdr48_human(display_long)|uniprotkb:WD repeat endosomal protein(gene name synonym)|uniprotkb:p80(gene name synonym)|uniprotkb:WDR48(gene name)|psi-mi:WDR48(display_short)|uniprotkb:KIAA1449(gene name synonym)|uniprotkb:UAF1(gene name synonym)|uniprotkb:USP1-associated factor 1(gene name synonym) psi-mi:phlp1_human(display_long)|uniprotkb:PHLPP1(gene name)|psi-mi:PHLPP1(display_short)|uniprotkb:KIAA0606(gene name synonym)|uniprotkb:PHLPP(gene name synonym)|uniprotkb:PLEKHE1(gene name synonym)|uniprotkb:SCOP(gene name synonym)|uniprotkb:Pleckstrin homology domain-containing family E member 1(gene name synonym)|uniprotkb:Suprachiasmatic nucleus circadian oscillatory protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515634|imex:IM-12079-49 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065890.1|ensembl:ENSG00000114742(gene)|ensembl:ENST00000302313(transcript)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0003677"(DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043588"(skin development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0072520"(seminiferous tubule development)|go:"GO:1902525"(regulation of protein monoubiquitination)|go:"GO:1903003"(positive regulation of protein deubiquitination)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR021772|interpro:IPR036322|mint:Q8TAF3|rcsb pdb:5CVL|rcsb pdb:5CVN|rcsb pdb:5CVO|rcsb pdb:5K1A|rcsb pdb:5K1B|rcsb pdb:5K1C|rcsb pdb:5L8E|rcsb pdb:5L8W|rcsb pdb:6JLQ|rcsb pdb:7AY0|rcsb pdb:7AY1|rcsb pdb:7AY2|reactome:R-HSA-110314|reactome:R-HSA-5689880|reactome:R-HSA-6783310|reactome:R-HSA-9673766|refseq:NP_001290331.1|refseq:NP_001290332.1|refseq:NP_001333156.1|refseq:NP_001333157.1|dip:DIP-50841N ensembl:ENSP00000262719|go:"GO:0009649"(entrainment of circadian clock)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046872"(metal ion binding)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1900744"(regulation of p38MAPK cascade)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001932(Protein phosphatase 2C-related)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR032675|interpro:IPR036457|mint:O60346|reactome:R-HSA-199418|ensembl:ENSG00000081913(gene)|ensembl:ENST00000262719(transcript)|go:"GO:0002667"(regulation of T cell anergy)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|refseq:NP_919431.2 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/05/28 rogid:S8ihl3jxEEyMS46AM2ynXSFfCU49606 rogid:hPGjeSVMlJhO3o9YBWoBm9xppfk9606 intact-crc:FEA84E4597BF2CAC|rigid:5VpwlpQqzlunHNK7tN6q4Wo+lkI false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8TAF3 uniprotkb:O43865 intact:EBI-1045469|uniprotkb:Q63HJ2|uniprotkb:Q658Y1|uniprotkb:Q8N3Z1|uniprotkb:Q9NSK8|uniprotkb:Q9P279|uniprotkb:B4DM86|uniprotkb:B4DQI2|uniprotkb:B4DY84|ensembl:ENSP00000307491 intact:EBI-2371423|uniprotkb:Q2TAJ6|uniprotkb:Q502W8|uniprotkb:Q5VSM0|uniprotkb:Q6P171|uniprotkb:Q96PK4|uniprotkb:Q9UG84|uniprotkb:B4E168|ensembl:ENSP00000358814 psi-mi:wdr48_human(display_long)|uniprotkb:WD repeat endosomal protein(gene name synonym)|uniprotkb:p80(gene name synonym)|uniprotkb:WDR48(gene name)|psi-mi:WDR48(display_short)|uniprotkb:KIAA1449(gene name synonym)|uniprotkb:UAF1(gene name synonym)|uniprotkb:USP1-associated factor 1(gene name synonym) psi-mi:sahh2_human(display_long)|uniprotkb:AHCYL1(gene name)|psi-mi:AHCYL1(display_short)|uniprotkb:DCAL(gene name synonym)|uniprotkb:XPVKONA(gene name synonym)|uniprotkb:S-adenosyl-L-homocysteine hydrolase 2(gene name synonym)|uniprotkb:DC-expressed AHCY-like molecule(gene name synonym)|uniprotkb:Putative adenosylhomocysteinase 2(gene name synonym)|uniprotkb:"IP(3)Rs binding protein released with IP(3)"(gene name synonym)|uniprotkb:IRBIT(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515634|imex:IM-12079-49 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065890.1|ensembl:ENSG00000114742(gene)|ensembl:ENST00000302313(transcript)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0003677"(DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043588"(skin development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0072520"(seminiferous tubule development)|go:"GO:1902525"(regulation of protein monoubiquitination)|go:"GO:1903003"(positive regulation of protein deubiquitination)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR021772|interpro:IPR036322|mint:Q8TAF3|rcsb pdb:5CVL|rcsb pdb:5CVN|rcsb pdb:5CVO|rcsb pdb:5K1A|rcsb pdb:5K1B|rcsb pdb:5K1C|rcsb pdb:5L8E|rcsb pdb:5L8W|rcsb pdb:6JLQ|rcsb pdb:7AY0|rcsb pdb:7AY1|rcsb pdb:7AY2|reactome:R-HSA-110314|reactome:R-HSA-5689880|reactome:R-HSA-6783310|reactome:R-HSA-9673766|refseq:NP_001290331.1|refseq:NP_001290332.1|refseq:NP_001333156.1|refseq:NP_001333157.1|dip:DIP-50841N refseq:NP_001229602.1|refseq:NP_001229603.1|refseq:NP_001229604.1|refseq:NP_001229605.1|refseq:NP_006612.2|ensembl:ENSG00000168710(gene)|ensembl:ENST00000369799(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006378"(mRNA polyadenylation)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0006730"(one-carbon metabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0010765"(positive regulation of sodium ion transport)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0031440"(regulation of mRNA 3'-end processing)|go:"GO:0032412"(regulation of ion transmembrane transporter activity)|go:"GO:0033353"(S-adenosylmethionine cycle)|go:"GO:0038166"(angiotensin-activated signaling pathway)|go:"GO:0042045"(epithelial fluid transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0044070"(regulation of anion transport)|go:"GO:0044233"(mitochondria-associated endoplasmic reticulum membrane)|go:"GO:0051592"(response to calcium ion)|go:"GO:0070062"(extracellular exosome)|go:"GO:1990456"(mitochondrion-endoplasmic reticulum membrane tethering)|interpro:IPR000043(S-adenosyl-L-homocysteine hydrolase)|interpro:IPR015878(S-adenosyl-L-homocysteine hydrolase, NAD binding)|interpro:IPR020082|interpro:IPR036291|interpro:IPR042172|mint:O43865|rcsb pdb:3MTG|reactome:R-HSA-112043|reactome:R-HSA-1489509|reactome:R-HSA-2029485|reactome:R-HSA-2871809|reactome:R-HSA-422356|reactome:R-HSA-5218921|reactome:R-HSA-5578775|reactome:R-HSA-5607763|reactome:R-HSA-9664323|reactome:R-HSA-983695 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/05/28 rogid:S8ihl3jxEEyMS46AM2ynXSFfCU49606 rogid:uwZ+P9SdKadoVn01p/b8qHp6egk9606 intact-crc:FEA84E4597BF2CAC|rigid:5VpwlpQqzlunHNK7tN6q4Wo+lkI false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8TAF3 uniprotkb:Q8IZK2 intact:EBI-1045469|uniprotkb:Q63HJ2|uniprotkb:Q658Y1|uniprotkb:Q8N3Z1|uniprotkb:Q9NSK8|uniprotkb:Q9P279|uniprotkb:B4DM86|uniprotkb:B4DQI2|uniprotkb:B4DY84|ensembl:ENSP00000307491 intact:EBI-2515428 psi-mi:wdr48_human(display_long)|uniprotkb:WD repeat endosomal protein(gene name synonym)|uniprotkb:p80(gene name synonym)|uniprotkb:WDR48(gene name)|psi-mi:WDR48(display_short)|uniprotkb:KIAA1449(gene name synonym)|uniprotkb:UAF1(gene name synonym)|uniprotkb:USP1-associated factor 1(gene name synonym) psi-mi:q8izk2_human(display_long)|uniprotkb:BRCA1(gene name)|psi-mi:BRCA1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515634|imex:IM-12079-49 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065890.1|ensembl:ENSG00000114742(gene)|ensembl:ENST00000302313(transcript)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0003677"(DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043588"(skin development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0072520"(seminiferous tubule development)|go:"GO:1902525"(regulation of protein monoubiquitination)|go:"GO:1903003"(positive regulation of protein deubiquitination)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR021772|interpro:IPR036322|mint:Q8TAF3|rcsb pdb:5CVL|rcsb pdb:5CVN|rcsb pdb:5CVO|rcsb pdb:5K1A|rcsb pdb:5K1B|rcsb pdb:5K1C|rcsb pdb:5L8E|rcsb pdb:5L8W|rcsb pdb:6JLQ|rcsb pdb:7AY0|rcsb pdb:7AY1|rcsb pdb:7AY2|reactome:R-HSA-110314|reactome:R-HSA-5689880|reactome:R-HSA-6783310|reactome:R-HSA-9673766|refseq:NP_001290331.1|refseq:NP_001290332.1|refseq:NP_001333156.1|refseq:NP_001333157.1|dip:DIP-50841N - psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/05/28 rogid:S8ihl3jxEEyMS46AM2ynXSFfCU49606 rogid:Bok4Ow6jvJlCxqNjMHB7SxsvLxg9606 intact-crc:FEA84E4597BF2CAC|rigid:5VpwlpQqzlunHNK7tN6q4Wo+lkI false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8TAF3 uniprotkb:Q09019 intact:EBI-1045469|uniprotkb:Q63HJ2|uniprotkb:Q658Y1|uniprotkb:Q8N3Z1|uniprotkb:Q9NSK8|uniprotkb:Q9P279|uniprotkb:B4DM86|uniprotkb:B4DQI2|uniprotkb:B4DY84|ensembl:ENSP00000307491 intact:EBI-724564|ensembl:ENSP00000270223 psi-mi:wdr48_human(display_long)|uniprotkb:WD repeat endosomal protein(gene name synonym)|uniprotkb:p80(gene name synonym)|uniprotkb:WDR48(gene name)|psi-mi:WDR48(display_short)|uniprotkb:KIAA1449(gene name synonym)|uniprotkb:UAF1(gene name synonym)|uniprotkb:USP1-associated factor 1(gene name synonym) psi-mi:dmwd_human(display_long)|uniprotkb:Dystrophia myotonica-containing WD repeat motif protein(gene name synonym)|uniprotkb:Protein DMR-N9(gene name synonym)|uniprotkb:Protein 59(gene name synonym)|uniprotkb:DMWD(gene name)|psi-mi:DMWD(display_short)|uniprotkb:DM9(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515634|imex:IM-12079-49 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065890.1|ensembl:ENSG00000114742(gene)|ensembl:ENST00000302313(transcript)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0003677"(DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043588"(skin development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0072520"(seminiferous tubule development)|go:"GO:1902525"(regulation of protein monoubiquitination)|go:"GO:1903003"(positive regulation of protein deubiquitination)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR021772|interpro:IPR036322|mint:Q8TAF3|rcsb pdb:5CVL|rcsb pdb:5CVN|rcsb pdb:5CVO|rcsb pdb:5K1A|rcsb pdb:5K1B|rcsb pdb:5K1C|rcsb pdb:5L8E|rcsb pdb:5L8W|rcsb pdb:6JLQ|rcsb pdb:7AY0|rcsb pdb:7AY1|rcsb pdb:7AY2|reactome:R-HSA-110314|reactome:R-HSA-5689880|reactome:R-HSA-6783310|reactome:R-HSA-9673766|refseq:NP_001290331.1|refseq:NP_001290332.1|refseq:NP_001333156.1|refseq:NP_001333157.1|dip:DIP-50841N refseq:NP_004934.1|ensembl:ENSG00000185800(gene)|ensembl:ENST00000270223(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0030425"(dendrite)|go:"GO:0043204"(perikaryon)|interpro:IPR001680(WD40 repeat)|interpro:IPR036322|mint:Q09019 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/05/28 rogid:S8ihl3jxEEyMS46AM2ynXSFfCU49606 rogid:76SLwlB1ohLxjwUwpPOR6gT4DP89606 intact-crc:FEA84E4597BF2CAC|rigid:5VpwlpQqzlunHNK7tN6q4Wo+lkI false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8TAF3 uniprotkb:Q13395 intact:EBI-1045469|uniprotkb:Q63HJ2|uniprotkb:Q658Y1|uniprotkb:Q8N3Z1|uniprotkb:Q9NSK8|uniprotkb:Q9P279|uniprotkb:B4DM86|uniprotkb:B4DQI2|uniprotkb:B4DY84|ensembl:ENSP00000307491 intact:EBI-2515586|ensembl:ENSP00000040877|uniprotkb:Q9H581 psi-mi:wdr48_human(display_long)|uniprotkb:WD repeat endosomal protein(gene name synonym)|uniprotkb:p80(gene name synonym)|uniprotkb:WDR48(gene name)|psi-mi:WDR48(display_short)|uniprotkb:KIAA1449(gene name synonym)|uniprotkb:UAF1(gene name synonym)|uniprotkb:USP1-associated factor 1(gene name synonym) psi-mi:tarb1_human(display_long)|uniprotkb:TARBP1(gene name)|psi-mi:TARBP1(display_short)|uniprotkb:TRM3(gene name synonym)|uniprotkb:TRP185(gene name synonym)|uniprotkb:TAR RNA-binding protein 1(gene name synonym)|uniprotkb:TAR RNA-binding protein of 185 kDa(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515634|imex:IM-12079-49 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065890.1|ensembl:ENSG00000114742(gene)|ensembl:ENST00000302313(transcript)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0003677"(DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043588"(skin development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0072520"(seminiferous tubule development)|go:"GO:1902525"(regulation of protein monoubiquitination)|go:"GO:1903003"(positive regulation of protein deubiquitination)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR021772|interpro:IPR036322|mint:Q8TAF3|rcsb pdb:5CVL|rcsb pdb:5CVN|rcsb pdb:5CVO|rcsb pdb:5K1A|rcsb pdb:5K1B|rcsb pdb:5K1C|rcsb pdb:5L8E|rcsb pdb:5L8W|rcsb pdb:6JLQ|rcsb pdb:7AY0|rcsb pdb:7AY1|rcsb pdb:7AY2|reactome:R-HSA-110314|reactome:R-HSA-5689880|reactome:R-HSA-6783310|reactome:R-HSA-9673766|refseq:NP_001290331.1|refseq:NP_001290332.1|refseq:NP_001333156.1|refseq:NP_001333157.1|dip:DIP-50841N ensembl:ENSG00000059588(gene)|ensembl:ENST00000040877(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0016423"("tRNA (guanine) methyltransferase activity")|go:"GO:0030488"(tRNA methylation)|interpro:IPR001537(tRNA/rRNA methyltransferase, SpoU)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR025806|interpro:IPR029026|interpro:IPR029028|interpro:IPR044748|rcsb pdb:2HA8|refseq:NP_005637.3 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/05/28 rogid:S8ihl3jxEEyMS46AM2ynXSFfCU49606 rogid:nTo6BVWftdY8LcSh7gDoWtCURK89606 intact-crc:FEA84E4597BF2CAC|rigid:5VpwlpQqzlunHNK7tN6q4Wo+lkI false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8TAF3 uniprotkb:Q7Z4G4 intact:EBI-1045469|uniprotkb:Q63HJ2|uniprotkb:Q658Y1|uniprotkb:Q8N3Z1|uniprotkb:Q9NSK8|uniprotkb:Q9P279|uniprotkb:B4DM86|uniprotkb:B4DQI2|uniprotkb:B4DY84|ensembl:ENSP00000307491 intact:EBI-2515608|uniprotkb:Q5JY11|uniprotkb:Q6PGQ5|uniprotkb:Q9HC13|uniprotkb:E1P570|ensembl:ENSP00000333934 psi-mi:wdr48_human(display_long)|uniprotkb:WD repeat endosomal protein(gene name synonym)|uniprotkb:p80(gene name synonym)|uniprotkb:WDR48(gene name)|psi-mi:WDR48(display_short)|uniprotkb:KIAA1449(gene name synonym)|uniprotkb:UAF1(gene name synonym)|uniprotkb:USP1-associated factor 1(gene name synonym) psi-mi:trm11_human(display_long)|uniprotkb:TRMT11(gene name)|psi-mi:TRMT11(display_short)|uniprotkb:C6orf75(gene name synonym)|uniprotkb:tRNA guanosine-2'-O-methyltransferase TRM11 homolog(gene name synonym)|uniprotkb:MDS024(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515634|imex:IM-12079-49 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065890.1|ensembl:ENSG00000114742(gene)|ensembl:ENST00000302313(transcript)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0003677"(DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043588"(skin development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0072520"(seminiferous tubule development)|go:"GO:1902525"(regulation of protein monoubiquitination)|go:"GO:1903003"(positive regulation of protein deubiquitination)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR021772|interpro:IPR036322|mint:Q8TAF3|rcsb pdb:5CVL|rcsb pdb:5CVN|rcsb pdb:5CVO|rcsb pdb:5K1A|rcsb pdb:5K1B|rcsb pdb:5K1C|rcsb pdb:5L8E|rcsb pdb:5L8W|rcsb pdb:6JLQ|rcsb pdb:7AY0|rcsb pdb:7AY1|rcsb pdb:7AY2|reactome:R-HSA-110314|reactome:R-HSA-5689880|reactome:R-HSA-6783310|reactome:R-HSA-9673766|refseq:NP_001290331.1|refseq:NP_001290332.1|refseq:NP_001333156.1|refseq:NP_001333157.1|dip:DIP-50841N refseq:NP_001026882.2|ensembl:ENSG00000066651(gene)|ensembl:ENST00000334379(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0004809"("tRNA (guanine-N2-)-methyltransferase activity")|go:"GO:0005737"(cytoplasm)|go:"GO:0008168"(methyltransferase activity)|interpro:IPR000241(Putative RNA methylase)|interpro:IPR002052(N-6 adenine-specific DNA methylase, conserved site)|interpro:IPR016691(tRNA guanosine-2'-O-methyltransferase, TRM11)|interpro:IPR029063|reactome:R-HSA-6782315 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/05/28 rogid:S8ihl3jxEEyMS46AM2ynXSFfCU49606 rogid:BCGxR/3+huZv9IKwcnXvO/PHzlY9606 intact-crc:FEA84E4597BF2CAC|rigid:5VpwlpQqzlunHNK7tN6q4Wo+lkI false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8TAF3 uniprotkb:Q9HCN4 intact:EBI-1045469|uniprotkb:Q63HJ2|uniprotkb:Q658Y1|uniprotkb:Q8N3Z1|uniprotkb:Q9NSK8|uniprotkb:Q9P279|uniprotkb:B4DM86|uniprotkb:B4DQI2|uniprotkb:B4DY84|ensembl:ENSP00000307491 intact:EBI-745137|uniprotkb:O76004|uniprotkb:B4DQJ5|uniprotkb:B4DXU4|uniprotkb:B4DQM4|ensembl:ENSP00000476446|uniprotkb:B5MBZ5 psi-mi:wdr48_human(display_long)|uniprotkb:WD repeat endosomal protein(gene name synonym)|uniprotkb:p80(gene name synonym)|uniprotkb:WDR48(gene name)|psi-mi:WDR48(display_short)|uniprotkb:KIAA1449(gene name synonym)|uniprotkb:UAF1(gene name synonym)|uniprotkb:USP1-associated factor 1(gene name synonym) psi-mi:gpn1_human(display_long)|uniprotkb:XAB1(gene name synonym)|uniprotkb:XPA-binding protein 1(gene name synonym)|uniprotkb:MBD2-interacting protein(gene name synonym)|uniprotkb:GPN1(gene name)|psi-mi:GPN1(display_short)|uniprotkb:MBDIN(gene name synonym)|uniprotkb:HUSSY-23(orf name)|uniprotkb:RNAPII-associated protein 4(gene name synonym)|uniprotkb:RPAP4(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515634|imex:IM-12079-49 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065890.1|ensembl:ENSG00000114742(gene)|ensembl:ENST00000302313(transcript)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0003677"(DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043588"(skin development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0072520"(seminiferous tubule development)|go:"GO:1902525"(regulation of protein monoubiquitination)|go:"GO:1903003"(positive regulation of protein deubiquitination)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR021772|interpro:IPR036322|mint:Q8TAF3|rcsb pdb:5CVL|rcsb pdb:5CVN|rcsb pdb:5CVO|rcsb pdb:5K1A|rcsb pdb:5K1B|rcsb pdb:5K1C|rcsb pdb:5L8E|rcsb pdb:5L8W|rcsb pdb:6JLQ|rcsb pdb:7AY0|rcsb pdb:7AY1|rcsb pdb:7AY2|reactome:R-HSA-110314|reactome:R-HSA-5689880|reactome:R-HSA-6783310|reactome:R-HSA-9673766|refseq:NP_001290331.1|refseq:NP_001290332.1|refseq:NP_001333156.1|refseq:NP_001333157.1|dip:DIP-50841N refseq:NP_001138519.1|refseq:NP_001138520.1|refseq:NP_001138521.1|refseq:NP_009197.2|ensembl:ENSG00000198522(gene)|ensembl:ENST00000610189(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR004130(Protein of unknown function, ATP binding)|interpro:IPR027417|interpro:IPR030230|mint:Q9HCN4 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/05/28 rogid:S8ihl3jxEEyMS46AM2ynXSFfCU49606 rogid:QZOTFh9d1hOcoG1DxAueYEwbOpc9606 intact-crc:FEA84E4597BF2CAC|rigid:5VpwlpQqzlunHNK7tN6q4Wo+lkI false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8TAF3 uniprotkb:P68400 intact:EBI-1045469|uniprotkb:Q63HJ2|uniprotkb:Q658Y1|uniprotkb:Q8N3Z1|uniprotkb:Q9NSK8|uniprotkb:Q9P279|uniprotkb:B4DM86|uniprotkb:B4DQI2|uniprotkb:B4DY84|ensembl:ENSP00000307491 intact:EBI-347804|ensembl:ENSP00000217244|ensembl:ENSP00000383076|ensembl:ENSP00000495248|ensembl:ENSP00000495422|ensembl:ENSP00000495902|ensembl:ENSP00000495912|ensembl:ENSP00000495998|ensembl:ENSP00000496569|uniprotkb:P19138|uniprotkb:P20426|uniprotkb:Q14013|uniprotkb:Q5U065|uniprotkb:D3DVV8|uniprotkb:B4DYS6 psi-mi:wdr48_human(display_long)|uniprotkb:WD repeat endosomal protein(gene name synonym)|uniprotkb:p80(gene name synonym)|uniprotkb:WDR48(gene name)|psi-mi:WDR48(display_short)|uniprotkb:KIAA1449(gene name synonym)|uniprotkb:UAF1(gene name synonym)|uniprotkb:USP1-associated factor 1(gene name synonym) psi-mi:csk21_human(display_long)|uniprotkb:CSNK2A1(gene name)|psi-mi:CSNK2A1(display_short)|uniprotkb:CK2A1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515634|imex:IM-12079-49 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065890.1|ensembl:ENSG00000114742(gene)|ensembl:ENST00000302313(transcript)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0003677"(DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043588"(skin development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0072520"(seminiferous tubule development)|go:"GO:1902525"(regulation of protein monoubiquitination)|go:"GO:1903003"(positive regulation of protein deubiquitination)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR021772|interpro:IPR036322|mint:Q8TAF3|rcsb pdb:5CVL|rcsb pdb:5CVN|rcsb pdb:5CVO|rcsb pdb:5K1A|rcsb pdb:5K1B|rcsb pdb:5K1C|rcsb pdb:5L8E|rcsb pdb:5L8W|rcsb pdb:6JLQ|rcsb pdb:7AY0|rcsb pdb:7AY1|rcsb pdb:7AY2|reactome:R-HSA-110314|reactome:R-HSA-5689880|reactome:R-HSA-6783310|reactome:R-HSA-9673766|refseq:NP_001290331.1|refseq:NP_001290332.1|refseq:NP_001333156.1|refseq:NP_001333157.1|dip:DIP-50841N rcsb pdb:6TLS|rcsb pdb:6TLU|rcsb pdb:6TLV|rcsb pdb:6TLW|rcsb pdb:6YPG|rcsb pdb:6YPH|rcsb pdb:6YPJ|rcsb pdb:6YPK|rcsb pdb:6YPN|rcsb pdb:6YUL|rcsb pdb:6YUM|rcsb pdb:6YZH|rcsb pdb:6Z19|rcsb pdb:6Z83|rcsb pdb:6Z84|rcsb pdb:7A49|rcsb pdb:6TLR|rcsb pdb:7A4B|rcsb pdb:7A4C|rcsb pdb:7B8H|rcsb pdb:3PE2|rcsb pdb:3PE4|rcsb pdb:3Q04|rcsb pdb:3Q9W|rcsb pdb:3Q9X|rcsb pdb:3Q9Y|rcsb pdb:3Q9Z|rcsb pdb:3QA0|rcsb pdb:3R0T|rcsb pdb:3RPS|rcsb pdb:3TAX|rcsb pdb:3U4U|rcsb pdb:3U87|rcsb pdb:3U9C|rcsb pdb:3W8L|rcsb pdb:3WAR|rcsb pdb:3WIK|rcsb pdb:3WIL|rcsb pdb:3WOW|rcsb pdb:3PE1|rcsb pdb:4DGL|rcsb pdb:4FBX|ensembl:ENSG00000101266(gene)|ensembl:ENST00000217244(transcript)|ensembl:ENST00000400217(transcript)|ensembl:ENST00000643660(transcript)|ensembl:ENST00000645623(transcript)|ensembl:ENST00000646305(transcript)|ensembl:ENST00000646561(transcript)|ensembl:ENST00000646814(transcript)|ensembl:ENST00000647348(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005956"(protein kinase CK2 complex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016301"(kinase activity)|go:"GO:0016580"(Sin3 complex)|go:"GO:0016581"(NuRD complex)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|rcsb pdb:4GUB|rcsb pdb:4GYW|rcsb pdb:4GYY|rcsb pdb:4GZ3|rcsb pdb:4IB5|rcsb pdb:4KWP|rcsb pdb:4MD7|rcsb pdb:4MD8|rcsb pdb:4MD9|rcsb pdb:4NH1|rcsb pdb:4RLL|rcsb pdb:4UB7|rcsb pdb:4GRB|rcsb pdb:4UBA|rcsb pdb:5B0X|rcsb pdb:5CLP|rcsb pdb:5CQU|rcsb pdb:5CQW|rcsb pdb:5CS6|rcsb pdb:5CSH|rcsb pdb:5CSP|rcsb pdb:5CSV|rcsb pdb:7BU4|rcsb pdb:7B8I|reactome:R-HSA-1483191|reactome:R-HSA-201688|reactome:R-HSA-2514853|reactome:R-HSA-445144|reactome:R-HSA-6804756|reactome:R-HSA-6814122|reactome:R-HSA-8932339|reactome:R-HSA-8934903|reactome:R-HSA-8939243|reactome:R-HSA-8948751|rcsb pdb:5CTP|rcsb pdb:5CU0|rcsb pdb:5CU2|rcsb pdb:5CU3|rcsb pdb:5CU4|rcsb pdb:5CU6|rcsb pdb:5CVF|rcsb pdb:5CVG|rcsb pdb:5CVH|rcsb pdb:5CX9|rcsb pdb:5H8B|rcsb pdb:5H8E|rcsb pdb:5H8G|rcsb pdb:5HGV|rcsb pdb:5KU8|rcsb pdb:5KWH|rcsb pdb:5M44|rcsb pdb:5M4C|rcsb pdb:5M4F|rcsb pdb:5M4I|rcsb pdb:5MMF|rcsb pdb:5MMR|rcsb pdb:5MO5|rcsb pdb:5MO6|rcsb pdb:5MO7|rcsb pdb:5MO8|rcsb pdb:5MOD|rcsb pdb:5MOE|rcsb pdb:5MOH|rcsb pdb:5MOT|rcsb pdb:5MOV|rcsb pdb:5MOW|rcsb pdb:5MP8|rcsb pdb:5MPJ|rcsb pdb:5N1V|rcsb pdb:5N9K|rcsb pdb:5N9L|rcsb pdb:5N9N|rcsb pdb:5NQC|rcsb pdb:5OMY|rcsb pdb:5ONI|rcsb pdb:5OQU|rcsb pdb:5ORH|rcsb pdb:5ORJ|rcsb pdb:5ORK|rcsb pdb:5CT0|rcsb pdb:5OT6|rcsb pdb:5OTD|rcsb pdb:5OTH|rcsb pdb:5OTI|rcsb pdb:5OTL|rcsb pdb:5OTO|rcsb pdb:5OTP|rcsb pdb:5OTQ|rcsb pdb:5OTR|rcsb pdb:5OTS|rcsb pdb:5OTY|rcsb pdb:5OTZ|rcsb pdb:5OUE|rcsb pdb:5OS7|rcsb pdb:5OUL|rcsb pdb:5OUM|rcsb pdb:5OS8|rcsb pdb:5OUU|rcsb pdb:5OWH|rcsb pdb:5OSL|rcsb pdb:5OWL|rcsb pdb:5OSP|rcsb pdb:5OYF|rcsb pdb:5T1H|rcsb pdb:5VIE|rcsb pdb:5VIF|rcsb pdb:5ZN0|rcsb pdb:5ZN1|rcsb pdb:5OSR|rcsb pdb:5OSU|rcsb pdb:5OSZ|rcsb pdb:5ZN2|rcsb pdb:5OT5|rcsb pdb:5ZN3|rcsb pdb:5ZN4|rcsb pdb:5ZN5|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048511"(rhythmic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1905818"(regulation of chromosome separation)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P68400|rcsb pdb:1JWH|rcsb pdb:1NA7|rcsb pdb:1PJK|rcsb pdb:2PVR|rcsb pdb:2ZJW|rcsb pdb:3AMY|rcsb pdb:3AT2|rcsb pdb:3AT3|rcsb pdb:3AT4|rcsb pdb:3AXW|rcsb pdb:3BQC|rcsb pdb:3C13|rcsb pdb:3FWQ|rcsb pdb:3H30|rcsb pdb:3JUH|rcsb pdb:3MB6|rcsb pdb:3MB7|rcsb pdb:3NGA|rcsb pdb:3NSZ|interpro:IPR011009(Protein kinase-like)|rcsb pdb:3OWJ|rcsb pdb:3OWK|rcsb pdb:3OWL|rcsb pdb:6E37|rcsb pdb:6EHK|rcsb pdb:6EHU|rcsb pdb:6EII|rcsb pdb:6FVF|rcsb pdb:6FVG|rcsb pdb:6GIH|rcsb pdb:6GMD|rcsb pdb:6HBN|rcsb pdb:6HME|rcsb pdb:6HNW|rcsb pdb:6HNY|rcsb pdb:6HOP|rcsb pdb:6HOQ|rcsb pdb:6HOR|rcsb pdb:6HOT|rcsb pdb:6HOU|rcsb pdb:6JWA|rcsb pdb:6L1Z|rcsb pdb:6L21|rcsb pdb:6L22|rcsb pdb:6L23|rcsb pdb:6L24|rcsb pdb:6Q38|rcsb pdb:6Q4Q|rcsb pdb:6QY7|rcsb pdb:6RB1|rcsb pdb:6RCB|rcsb pdb:6RCM|rcsb pdb:6RFE|rcsb pdb:6RFF|rcsb pdb:6SPW|rcsb pdb:6A1C|rcsb pdb:6SPX|rcsb pdb:6TEI|rcsb pdb:6TLL|rcsb pdb:6TLO|rcsb pdb:6TLP|refseq:NP_001886.1|refseq:NP_808227.1|refseq:NP_808228.1|dip:DIP-32682N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/05/28 rogid:S8ihl3jxEEyMS46AM2ynXSFfCU49606 rogid:5PLQNJJpbPzJhA0sqogKhl9umIQ9606 intact-crc:FEA84E4597BF2CAC|rigid:5VpwlpQqzlunHNK7tN6q4Wo+lkI false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8TAF3 uniprotkb:O75164 intact:EBI-1045469|uniprotkb:Q63HJ2|uniprotkb:Q658Y1|uniprotkb:Q8N3Z1|uniprotkb:Q9NSK8|uniprotkb:Q9P279|uniprotkb:B4DM86|uniprotkb:B4DQI2|uniprotkb:B4DY84|ensembl:ENSP00000307491 intact:EBI-936709|uniprotkb:Q5VVB1|ensembl:ENSP00000361473 psi-mi:wdr48_human(display_long)|uniprotkb:WD repeat endosomal protein(gene name synonym)|uniprotkb:p80(gene name synonym)|uniprotkb:WDR48(gene name)|psi-mi:WDR48(display_short)|uniprotkb:KIAA1449(gene name synonym)|uniprotkb:UAF1(gene name synonym)|uniprotkb:USP1-associated factor 1(gene name synonym) psi-mi:kdm4a_human(display_long)|uniprotkb:KDM4A(gene name)|psi-mi:KDM4A(display_short)|uniprotkb:JMJD2(gene name synonym)|uniprotkb:KIAA0677(gene name synonym)|uniprotkb:Jumonji domain-containing protein 2A(gene name synonym)|uniprotkb:JHDM3A(gene name synonym)|uniprotkb:"[histone H3]-trimethyl-L-lysine(36) demethylase 4A"(gene name synonym)|uniprotkb:"[histone H3]-trimethyl-L-lysine(9) demethylase 4A"(gene name synonym)|uniprotkb:JMJD2A(gene name synonym)|uniprotkb:JmjC domain-containing histone demethylation protein 3A(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515634|imex:IM-12079-49 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065890.1|ensembl:ENSG00000114742(gene)|ensembl:ENST00000302313(transcript)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0003677"(DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043588"(skin development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0072520"(seminiferous tubule development)|go:"GO:1902525"(regulation of protein monoubiquitination)|go:"GO:1903003"(positive regulation of protein deubiquitination)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR021772|interpro:IPR036322|mint:Q8TAF3|rcsb pdb:5CVL|rcsb pdb:5CVN|rcsb pdb:5CVO|rcsb pdb:5K1A|rcsb pdb:5K1B|rcsb pdb:5K1C|rcsb pdb:5L8E|rcsb pdb:5L8W|rcsb pdb:6JLQ|rcsb pdb:7AY0|rcsb pdb:7AY1|rcsb pdb:7AY2|reactome:R-HSA-110314|reactome:R-HSA-5689880|reactome:R-HSA-6783310|reactome:R-HSA-9673766|refseq:NP_001290331.1|refseq:NP_001290332.1|refseq:NP_001333156.1|refseq:NP_001333157.1|dip:DIP-50841N refseq:NP_055478.2|refseq:XP_005271411.1|refseq:XP_005271412.1|dip:DIP-29372N|ensembl:ENSG00000066135(gene)|ensembl:ENST00000372396(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014898"(cardiac muscle hypertrophy in response to stress)|go:"GO:0016577"(histone demethylation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0032452"(histone demethylase activity)|go:"GO:0032454"(histone H3-methyl-lysine-9 demethylase activity)|go:"GO:0033169"(histone H3-K9 demethylation)|go:"GO:0035064"(methylated histone binding)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|go:"GO:0051864"(histone H3-methyl-lysine-36 demethylase activity)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070544"(histone H3-K36 demethylation)|go:"GO:1900113"(negative regulation of histone H3-K9 trimethylation)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR002999(Tudor)|interpro:IPR003347(Transcription factor jumonji/aspartyl beta-hydroxylase)|interpro:IPR003349(Transcription factor jumonji, JmjN)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR034732|interpro:IPR040477|mint:O75164|rcsb pdb:2GF7|rcsb pdb:2GFA|rcsb pdb:2GP3|rcsb pdb:2GP5|rcsb pdb:2OQ6|rcsb pdb:2OQ7|rcsb pdb:2OS2|rcsb pdb:2OT7|rcsb pdb:2OX0|rcsb pdb:2P5B|rcsb pdb:2PXJ|rcsb pdb:2Q8C|rcsb pdb:2Q8D|rcsb pdb:2Q8E|rcsb pdb:2QQR|rcsb pdb:2QQS|rcsb pdb:2VD7|rcsb pdb:2WWJ|rcsb pdb:2YBK|rcsb pdb:2YBP|rcsb pdb:2YBS|rcsb pdb:3NJY|rcsb pdb:3PDQ|rcsb pdb:3RVH|rcsb pdb:3U4S|rcsb pdb:4AI9|rcsb pdb:4BIS|rcsb pdb:4GD4|rcsb pdb:4URA|rcsb pdb:4V2V|rcsb pdb:4V2W|rcsb pdb:5A7N|rcsb pdb:5A7O|rcsb pdb:5A7P|rcsb pdb:5A7Q|rcsb pdb:5A7S|rcsb pdb:5A7W|rcsb pdb:5A80|rcsb pdb:5ANQ|rcsb pdb:5D6W|rcsb pdb:5D6X|rcsb pdb:5D6Y|rcsb pdb:5F2S|rcsb pdb:5F2W|rcsb pdb:5F32|rcsb pdb:5F37|rcsb pdb:5F39|rcsb pdb:5F3C|rcsb pdb:5F3E|rcsb pdb:5F3G|rcsb pdb:5F3I|rcsb pdb:5F5I|rcsb pdb:5FPV|rcsb pdb:5FWE|rcsb pdb:5FY8|rcsb pdb:5FYC|rcsb pdb:5FYH|rcsb pdb:5FYI|rcsb pdb:5LY1|rcsb pdb:5LY2|rcsb pdb:5TVR|rcsb pdb:5TVS|rcsb pdb:5VAR|rcsb pdb:5VGI|rcsb pdb:5VMP|rcsb pdb:6CG1|rcsb pdb:6CG2|rcsb pdb:6G5W|rcsb pdb:6G5X|rcsb pdb:6H4O|rcsb pdb:6H4P|rcsb pdb:6H4Q|rcsb pdb:6H4R|rcsb pdb:6H4S|rcsb pdb:6H4T|rcsb pdb:6H4U|rcsb pdb:6H4V|rcsb pdb:6H4W|rcsb pdb:6H4X|rcsb pdb:6H4Y|rcsb pdb:6H8P|rcsb pdb:6HGT|rcsb pdb:7D4A|reactome:R-HSA-3214842|reactome:R-HSA-5693565|reactome:R-HSA-9029569 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/05/28 rogid:S8ihl3jxEEyMS46AM2ynXSFfCU49606 rogid:P8atv/4zKIc7bVg3IZYlw5gVIHY9606 intact-crc:FEA84E4597BF2CAC|rigid:5VpwlpQqzlunHNK7tN6q4Wo+lkI false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8TAF3 uniprotkb:Q86T24 intact:EBI-1045469|uniprotkb:Q63HJ2|uniprotkb:Q658Y1|uniprotkb:Q8N3Z1|uniprotkb:Q9NSK8|uniprotkb:Q9P279|uniprotkb:B4DM86|uniprotkb:B4DQI2|uniprotkb:B4DY84|ensembl:ENSP00000307491 intact:EBI-2515625|ensembl:ENSP00000314153|ensembl:ENSP00000450969|uniprotkb:Q7Z361|uniprotkb:Q8N3P0|uniprotkb:Q8IVP6|uniprotkb:O00319|uniprotkb:B2R5U6 psi-mi:wdr48_human(display_long)|uniprotkb:WD repeat endosomal protein(gene name synonym)|uniprotkb:p80(gene name synonym)|uniprotkb:WDR48(gene name)|psi-mi:WDR48(display_short)|uniprotkb:KIAA1449(gene name synonym)|uniprotkb:UAF1(gene name synonym)|uniprotkb:USP1-associated factor 1(gene name synonym) psi-mi:kaiso_human(display_long)|uniprotkb:ZBTB33(gene name)|psi-mi:ZBTB33(display_short)|uniprotkb:KAISO(gene name synonym)|uniprotkb:ZNF348(gene name synonym)|uniprotkb:Zinc finger and BTB domain-containing protein 33(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515634|imex:IM-12079-49 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065890.1|ensembl:ENSG00000114742(gene)|ensembl:ENST00000302313(transcript)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0003677"(DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043588"(skin development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0072520"(seminiferous tubule development)|go:"GO:1902525"(regulation of protein monoubiquitination)|go:"GO:1903003"(positive regulation of protein deubiquitination)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR021772|interpro:IPR036322|mint:Q8TAF3|rcsb pdb:5CVL|rcsb pdb:5CVN|rcsb pdb:5CVO|rcsb pdb:5K1A|rcsb pdb:5K1B|rcsb pdb:5K1C|rcsb pdb:5L8E|rcsb pdb:5L8W|rcsb pdb:6JLQ|rcsb pdb:7AY0|rcsb pdb:7AY1|rcsb pdb:7AY2|reactome:R-HSA-110314|reactome:R-HSA-5689880|reactome:R-HSA-6783310|reactome:R-HSA-9673766|refseq:NP_001290331.1|refseq:NP_001290332.1|refseq:NP_001333156.1|refseq:NP_001333157.1|dip:DIP-50841N ensembl:ENSG00000177485(gene)|ensembl:ENST00000326624(transcript)|ensembl:ENST00000557385(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008327"(methyl-CpG binding)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|rcsb pdb:2LT7|rcsb pdb:3FKC|rcsb pdb:3M4T|rcsb pdb:3M8V|rcsb pdb:4F6M|rcsb pdb:4F6N|rcsb pdb:5VMU|rcsb pdb:5VMV|rcsb pdb:5VMW|rcsb pdb:5VMX|rcsb pdb:5VMY|rcsb pdb:5VMZ|rcsb pdb:6DF5|rcsb pdb:6DF8|rcsb pdb:6DF9|rcsb pdb:6DFA|rcsb pdb:6DFB|rcsb pdb:6DFC|rcsb pdb:6V8U|refseq:NP_001171671.1|refseq:NP_006768.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/05/28 rogid:S8ihl3jxEEyMS46AM2ynXSFfCU49606 rogid:nD+3FCTCYxUrXZXpBW5Co1V0CHc9606 intact-crc:FEA84E4597BF2CAC|rigid:5VpwlpQqzlunHNK7tN6q4Wo+lkI false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8TAF3 uniprotkb:O60716 intact:EBI-1045469|uniprotkb:Q63HJ2|uniprotkb:Q658Y1|uniprotkb:Q8N3Z1|uniprotkb:Q9NSK8|uniprotkb:Q9P279|uniprotkb:B4DM86|uniprotkb:B4DQI2|uniprotkb:B4DY84|ensembl:ENSP00000307491 intact:EBI-701927|uniprotkb:A8K939|uniprotkb:Q6DHZ7|uniprotkb:O15088|uniprotkb:O60713|uniprotkb:O60714|uniprotkb:O60715|uniprotkb:O60935|uniprotkb:Q6RBX8|uniprotkb:Q9UP71|uniprotkb:Q9UP72|uniprotkb:Q9UP73|ensembl:ENSP00000382004 psi-mi:wdr48_human(display_long)|uniprotkb:WD repeat endosomal protein(gene name synonym)|uniprotkb:p80(gene name synonym)|uniprotkb:WDR48(gene name)|psi-mi:WDR48(display_short)|uniprotkb:KIAA1449(gene name synonym)|uniprotkb:UAF1(gene name synonym)|uniprotkb:USP1-associated factor 1(gene name synonym) psi-mi:ctnd1_human(display_long)|uniprotkb:p120 catenin(gene name synonym)|uniprotkb:Cadherin-associated Src substrate(gene name synonym)|uniprotkb:"p120(cas)"(gene name synonym)|uniprotkb:CTNND1(gene name)|psi-mi:CTNND1(display_short)|uniprotkb:KIAA0384(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515634|imex:IM-12079-49 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065890.1|ensembl:ENSG00000114742(gene)|ensembl:ENST00000302313(transcript)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0003677"(DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043588"(skin development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0072520"(seminiferous tubule development)|go:"GO:1902525"(regulation of protein monoubiquitination)|go:"GO:1903003"(positive regulation of protein deubiquitination)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR021772|interpro:IPR036322|mint:Q8TAF3|rcsb pdb:5CVL|rcsb pdb:5CVN|rcsb pdb:5CVO|rcsb pdb:5K1A|rcsb pdb:5K1B|rcsb pdb:5K1C|rcsb pdb:5L8E|rcsb pdb:5L8W|rcsb pdb:6JLQ|rcsb pdb:7AY0|rcsb pdb:7AY1|rcsb pdb:7AY2|reactome:R-HSA-110314|reactome:R-HSA-5689880|reactome:R-HSA-6783310|reactome:R-HSA-9673766|refseq:NP_001290331.1|refseq:NP_001290332.1|refseq:NP_001333156.1|refseq:NP_001333157.1|dip:DIP-50841N refseq:NP_001078927.1|refseq:NP_001078928.1|refseq:NP_001078929.1|refseq:NP_001078930.1|refseq:NP_001078931.1|refseq:NP_001078932.1|refseq:NP_001078933.1|refseq:NP_001078934.1|refseq:NP_001078935.1|refseq:NP_001078936.1|refseq:NP_001078937.1|refseq:NP_001078938.1|refseq:NP_001193812.1|refseq:NP_001193813.1|refseq:NP_001193814.1|refseq:NP_001193815.1|refseq:NP_001193816.1|refseq:NP_001193817.1|refseq:NP_001193818.1|refseq:NP_001193819.1|refseq:NP_001193820.1|refseq:NP_001322.1|dip:DIP-33850N|ensembl:ENSG00000198561(gene)|ensembl:ENST00000399050(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005915"(zonula adherens)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0007420"(brain development)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016342"(catenin complex)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030426"(growth cone)|go:"GO:0030496"(midbody)|go:"GO:0043197"(dendritic spine)|go:"GO:0044331"(cell-cell adhesion mediated by cadherin)|go:"GO:0045296"(cadherin binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098831"(presynaptic active zone cytoplasmic component)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099072"(regulation of postsynaptic membrane neurotransmitter receptor levels)|go:"GO:0099092"(postsynaptic density, intracellular component)|interpro:IPR000225(Armadillo)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR028435|interpro:IPR028439|mint:O60716|rcsb pdb:3L6X|rcsb pdb:3L6Y|reactome:R-HSA-418990|reactome:R-HSA-5218920|reactome:R-HSA-8876493 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/05/28 rogid:S8ihl3jxEEyMS46AM2ynXSFfCU49606 rogid:HgMvbcDKedE291TIvIOqLFT3srw9606 intact-crc:FEA84E4597BF2CAC|rigid:5VpwlpQqzlunHNK7tN6q4Wo+lkI false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8TAF3 uniprotkb:P11274 intact:EBI-1045469|uniprotkb:Q63HJ2|uniprotkb:Q658Y1|uniprotkb:Q8N3Z1|uniprotkb:Q9NSK8|uniprotkb:Q9P279|uniprotkb:B4DM86|uniprotkb:B4DQI2|uniprotkb:B4DY84|ensembl:ENSP00000307491 intact:EBI-712838|intact:EBI-28971369|ensembl:ENSP00000303507|uniprotkb:P78501|uniprotkb:Q12842|uniprotkb:Q4LE80|uniprotkb:Q6NZI3 psi-mi:wdr48_human(display_long)|uniprotkb:WD repeat endosomal protein(gene name synonym)|uniprotkb:p80(gene name synonym)|uniprotkb:WDR48(gene name)|psi-mi:WDR48(display_short)|uniprotkb:KIAA1449(gene name synonym)|uniprotkb:UAF1(gene name synonym)|uniprotkb:USP1-associated factor 1(gene name synonym) psi-mi:bcr_human(display_long)|uniprotkb:Renal carcinoma antigen NY-REN-26(gene name synonym)|uniprotkb:BCR(gene name)|psi-mi:BCR(display_short)|uniprotkb:BCR1(gene name synonym)|uniprotkb:D22S11(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515634|imex:IM-12079-49 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065890.1|ensembl:ENSG00000114742(gene)|ensembl:ENST00000302313(transcript)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0003677"(DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043588"(skin development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0072520"(seminiferous tubule development)|go:"GO:1902525"(regulation of protein monoubiquitination)|go:"GO:1903003"(positive regulation of protein deubiquitination)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR021772|interpro:IPR036322|mint:Q8TAF3|rcsb pdb:5CVL|rcsb pdb:5CVN|rcsb pdb:5CVO|rcsb pdb:5K1A|rcsb pdb:5K1B|rcsb pdb:5K1C|rcsb pdb:5L8E|rcsb pdb:5L8W|rcsb pdb:6JLQ|rcsb pdb:7AY0|rcsb pdb:7AY1|rcsb pdb:7AY2|reactome:R-HSA-110314|reactome:R-HSA-5689880|reactome:R-HSA-6783310|reactome:R-HSA-9673766|refseq:NP_001290331.1|refseq:NP_001290332.1|refseq:NP_001333156.1|refseq:NP_001333157.1|dip:DIP-50841N ensembl:ENSG00000186716(gene)|ensembl:ENST00000305877(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030424"(axon)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0043197"(dendritic spine)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|go:"GO:0070062"(extracellular exosome)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000198(RhoGAP)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR015123(Bcr-Abl oncoprotein oligomerisation)|interpro:IPR035892|interpro:IPR035899|interpro:IPR036481|interpro:IPR037769|rcsb pdb:1K1F|rcsb pdb:2AIN|rcsb pdb:5N6R|rcsb pdb:5N7E|rcsb pdb:5OC7|reactome:R-HSA-1839117|reactome:R-HSA-5655302|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013423|mint:P11274|ensembl:ENSP00000303507|ensembl:ENST00000359540|ensembl:ENSP00000352535|refseq:NP_004318.3|refseq:NP_067585.2 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/05/28 rogid:S8ihl3jxEEyMS46AM2ynXSFfCU49606 rogid:U2+lPQ5c2dVW2MPLvknA0Bbg4fA9606 intact-crc:FEA84E4597BF2CAC|rigid:5VpwlpQqzlunHNK7tN6q4Wo+lkI false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8TAF3 uniprotkb:P23284 intact:EBI-1045469|uniprotkb:Q63HJ2|uniprotkb:Q658Y1|uniprotkb:Q8N3Z1|uniprotkb:Q9NSK8|uniprotkb:Q9P279|uniprotkb:B4DM86|uniprotkb:B4DQI2|uniprotkb:B4DY84|ensembl:ENSP00000307491 intact:EBI-359252|uniprotkb:Q9BVK5|uniprotkb:A8K534|uniprotkb:Q6IBH5|ensembl:ENSP00000300026 psi-mi:wdr48_human(display_long)|uniprotkb:WD repeat endosomal protein(gene name synonym)|uniprotkb:p80(gene name synonym)|uniprotkb:WDR48(gene name)|psi-mi:WDR48(display_short)|uniprotkb:KIAA1449(gene name synonym)|uniprotkb:UAF1(gene name synonym)|uniprotkb:USP1-associated factor 1(gene name synonym) psi-mi:ppib_human(display_long)|uniprotkb:PPIB(gene name)|psi-mi:PPIB(display_short)|uniprotkb:CYPB(gene name synonym)|uniprotkb:Cyclophilin B(gene name synonym)|uniprotkb:S-cyclophilin(gene name synonym)|uniprotkb:CYP-S1(gene name synonym)|uniprotkb:Rotamase B(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515634|imex:IM-12079-49 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065890.1|ensembl:ENSG00000114742(gene)|ensembl:ENST00000302313(transcript)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0003677"(DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043588"(skin development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0072520"(seminiferous tubule development)|go:"GO:1902525"(regulation of protein monoubiquitination)|go:"GO:1903003"(positive regulation of protein deubiquitination)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR021772|interpro:IPR036322|mint:Q8TAF3|rcsb pdb:5CVL|rcsb pdb:5CVN|rcsb pdb:5CVO|rcsb pdb:5K1A|rcsb pdb:5K1B|rcsb pdb:5K1C|rcsb pdb:5L8E|rcsb pdb:5L8W|rcsb pdb:6JLQ|rcsb pdb:7AY0|rcsb pdb:7AY1|rcsb pdb:7AY2|reactome:R-HSA-110314|reactome:R-HSA-5689880|reactome:R-HSA-6783310|reactome:R-HSA-9673766|refseq:NP_001290331.1|refseq:NP_001290332.1|refseq:NP_001333156.1|refseq:NP_001333157.1|dip:DIP-50841N refseq:NP_000933.1|ensembl:ENSG00000166794(gene)|ensembl:ENST00000300026(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003723"(RNA binding)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005925"(focal adhesion)|go:"GO:0006457"(protein folding)|go:"GO:0016018"(cyclosporin A binding)|go:"GO:0016020"(membrane)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034663"(endoplasmic reticulum chaperone complex)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042470"(melanosome)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044794"(positive regulation by host of viral process)|go:"GO:0044829"(positive regulation by host of viral genome replication)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0060348"(bone development)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070063"(RNA polymerase binding)|interpro:IPR002130(Peptidyl-prolyl cis-trans isomerase, cyclophilin-type)|interpro:IPR020892|interpro:IPR029000|mint:P23284|rcsb pdb:1CYN|rcsb pdb:3ICH|rcsb pdb:3ICI|reactome:R-HSA-1650814 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/05/28 rogid:S8ihl3jxEEyMS46AM2ynXSFfCU49606 rogid:h6nKaPUyEYUctYuu/3XfFhM4y9c9606 intact-crc:FEA84E4597BF2CAC|rigid:5VpwlpQqzlunHNK7tN6q4Wo+lkI false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8TAF3 uniprotkb:O75317 intact:EBI-1045469|uniprotkb:Q63HJ2|uniprotkb:Q658Y1|uniprotkb:Q8N3Z1|uniprotkb:Q9NSK8|uniprotkb:Q9P279|uniprotkb:B4DM86|uniprotkb:B4DQI2|uniprotkb:B4DY84|ensembl:ENSP00000307491 intact:EBI-2511507|ensembl:ENSP00000282344|uniprotkb:Q8TC49|uniprotkb:Q5VZV3|uniprotkb:A8K0X0 psi-mi:wdr48_human(display_long)|uniprotkb:WD repeat endosomal protein(gene name synonym)|uniprotkb:p80(gene name synonym)|uniprotkb:WDR48(gene name)|psi-mi:WDR48(display_short)|uniprotkb:KIAA1449(gene name synonym)|uniprotkb:UAF1(gene name synonym)|uniprotkb:USP1-associated factor 1(gene name synonym) psi-mi:ubp12_human(display_long)|uniprotkb:USP12(gene name)|psi-mi:USP12(display_short)|uniprotkb:UBH1(gene name synonym)|uniprotkb:USP12L1(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 12(gene name synonym)|uniprotkb:Deubiquitinating enzyme 12(gene name synonym)|uniprotkb:Ubiquitin-hydrolyzing enzyme 1(gene name synonym)|uniprotkb:Ubiquitin thioesterase 12(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515634|imex:IM-12079-49 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065890.1|ensembl:ENSG00000114742(gene)|ensembl:ENST00000302313(transcript)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0003677"(DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043588"(skin development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0072520"(seminiferous tubule development)|go:"GO:1902525"(regulation of protein monoubiquitination)|go:"GO:1903003"(positive regulation of protein deubiquitination)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR021772|interpro:IPR036322|mint:Q8TAF3|rcsb pdb:5CVL|rcsb pdb:5CVN|rcsb pdb:5CVO|rcsb pdb:5K1A|rcsb pdb:5K1B|rcsb pdb:5K1C|rcsb pdb:5L8E|rcsb pdb:5L8W|rcsb pdb:6JLQ|rcsb pdb:7AY0|rcsb pdb:7AY1|rcsb pdb:7AY2|reactome:R-HSA-110314|reactome:R-HSA-5689880|reactome:R-HSA-6783310|reactome:R-HSA-9673766|refseq:NP_001290331.1|refseq:NP_001290332.1|refseq:NP_001333156.1|refseq:NP_001333157.1|dip:DIP-50841N ensembl:ENSG00000152484(gene)|ensembl:ENST00000282344(transcript)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0046872"(metal ion binding)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|mint:O75317|rcsb pdb:5K16|rcsb pdb:5K1A|rcsb pdb:5K1B|rcsb pdb:5K1C|rcsb pdb:5L8W|reactome:R-HSA-5689880|refseq:NP_872294.2 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/05/28 rogid:S8ihl3jxEEyMS46AM2ynXSFfCU49606 rogid:SiueMBicjAsFl2OGlBfQ6tg1cf89606 intact-crc:FEA84E4597BF2CAC|rigid:5VpwlpQqzlunHNK7tN6q4Wo+lkI false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8TAF3 uniprotkb:Q96ST2 intact:EBI-1045469|uniprotkb:Q63HJ2|uniprotkb:Q658Y1|uniprotkb:Q8N3Z1|uniprotkb:Q9NSK8|uniprotkb:Q9P279|uniprotkb:B4DM86|uniprotkb:B4DQI2|uniprotkb:B4DY84|ensembl:ENSP00000307491 intact:EBI-2515615|ensembl:ENSP00000295321|uniprotkb:Q2TB65|uniprotkb:Q9NV97|uniprotkb:Q96MI7|uniprotkb:Q9NWH8|uniprotkb:Q6P157|uniprotkb:Q8N3E8 psi-mi:wdr48_human(display_long)|uniprotkb:WD repeat endosomal protein(gene name synonym)|uniprotkb:p80(gene name synonym)|uniprotkb:WDR48(gene name)|psi-mi:WDR48(display_short)|uniprotkb:KIAA1449(gene name synonym)|uniprotkb:UAF1(gene name synonym)|uniprotkb:USP1-associated factor 1(gene name synonym) psi-mi:iws1_human(display_long)|uniprotkb:IWS1(gene name)|psi-mi:IWS1(display_short)|uniprotkb:IWS1L(gene name synonym)|uniprotkb:IWS1-like protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515634|imex:IM-12079-49 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065890.1|ensembl:ENSG00000114742(gene)|ensembl:ENST00000302313(transcript)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0003677"(DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043588"(skin development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0072520"(seminiferous tubule development)|go:"GO:1902525"(regulation of protein monoubiquitination)|go:"GO:1903003"(positive regulation of protein deubiquitination)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR021772|interpro:IPR036322|mint:Q8TAF3|rcsb pdb:5CVL|rcsb pdb:5CVN|rcsb pdb:5CVO|rcsb pdb:5K1A|rcsb pdb:5K1B|rcsb pdb:5K1C|rcsb pdb:5L8E|rcsb pdb:5L8W|rcsb pdb:6JLQ|rcsb pdb:7AY0|rcsb pdb:7AY1|rcsb pdb:7AY2|reactome:R-HSA-110314|reactome:R-HSA-5689880|reactome:R-HSA-6783310|reactome:R-HSA-9673766|refseq:NP_001290331.1|refseq:NP_001290332.1|refseq:NP_001333156.1|refseq:NP_001333157.1|dip:DIP-50841N ensembl:ENSG00000163166(gene)|ensembl:ENST00000295321(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0010793"(regulation of mRNA export from nucleus)|go:"GO:0016973"("poly(A)+ mRNA export from nucleus")|go:"GO:0050684"(regulation of mRNA processing)|go:"GO:0090239"(regulation of histone H4 acetylation)|go:"GO:2001253"(regulation of histone H3-K36 trimethylation)|interpro:IPR017923|interpro:IPR035441|mint:Q96ST2|rcsb pdb:6EMR|reactome:R-HSA-112382|reactome:R-HSA-674695|reactome:R-HSA-75955|refseq:NP_060439.2 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/05/28 rogid:S8ihl3jxEEyMS46AM2ynXSFfCU49606 rogid:G7KjbkwlfWdg2VufnJfRBiS/yUs9606 intact-crc:FEA84E4597BF2CAC|rigid:5VpwlpQqzlunHNK7tN6q4Wo+lkI false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8TAF3 uniprotkb:Q96SB3 intact:EBI-1045469|uniprotkb:Q63HJ2|uniprotkb:Q658Y1|uniprotkb:Q8N3Z1|uniprotkb:Q9NSK8|uniprotkb:Q9P279|uniprotkb:B4DM86|uniprotkb:B4DQI2|uniprotkb:B4DY84|ensembl:ENSP00000307491 intact:EBI-351275|uniprotkb:Q8TCR9|intact:EBI-28984643|ensembl:ENSP00000478767|intact:EBI-4401886|uniprotkb:D3DTX6 psi-mi:wdr48_human(display_long)|uniprotkb:WD repeat endosomal protein(gene name synonym)|uniprotkb:p80(gene name synonym)|uniprotkb:WDR48(gene name)|psi-mi:WDR48(display_short)|uniprotkb:KIAA1449(gene name synonym)|uniprotkb:UAF1(gene name synonym)|uniprotkb:USP1-associated factor 1(gene name synonym) psi-mi:neb2_human(display_long)|uniprotkb:Neurabin-II(gene name synonym)|uniprotkb:Spinophilin(gene name synonym)|uniprotkb:Protein phosphatase 1 regulatory subunit 9B(gene name synonym)|uniprotkb:PPP1R9B(gene name)|psi-mi:PPP1R9B(display_short)|uniprotkb:PPP1R6(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515634|imex:IM-12079-49 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065890.1|ensembl:ENSG00000114742(gene)|ensembl:ENST00000302313(transcript)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0003677"(DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043588"(skin development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0072520"(seminiferous tubule development)|go:"GO:1902525"(regulation of protein monoubiquitination)|go:"GO:1903003"(positive regulation of protein deubiquitination)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR021772|interpro:IPR036322|mint:Q8TAF3|rcsb pdb:5CVL|rcsb pdb:5CVN|rcsb pdb:5CVO|rcsb pdb:5K1A|rcsb pdb:5K1B|rcsb pdb:5K1C|rcsb pdb:5L8E|rcsb pdb:5L8W|rcsb pdb:6JLQ|rcsb pdb:7AY0|rcsb pdb:7AY1|rcsb pdb:7AY2|reactome:R-HSA-110314|reactome:R-HSA-5689880|reactome:R-HSA-6783310|reactome:R-HSA-9673766|refseq:NP_001290331.1|refseq:NP_001290332.1|refseq:NP_001333156.1|refseq:NP_001333157.1|dip:DIP-50841N ensembl:ENSG00000108819(gene)|ensembl:ENST00000612501(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0001560"(regulation of cell growth by extracellular stimulus)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001975"(response to amphetamine)|go:"GO:0003006"(developmental process involved in reproduction)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004864"(protein phosphatase inhibitor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0007015"(actin filament organization)|go:"GO:0007096"(regulation of exit from mitosis)|go:"GO:0007568"(aging)|go:"GO:0007612"(learning)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0008380"(RNA splicing)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016358"(dendrite development)|go:"GO:0016477"(cell migration)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019900"(kinase binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030042"(actin filament depolymerization)|go:"GO:0030175"(filopodium)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031175"(neuron projection development)|go:"GO:0031749"(D2 dopamine receptor binding)|go:"GO:0032515"(negative regulation of phosphoprotein phosphatase activity)|go:"GO:0032587"(ruffle membrane)|go:"GO:0034695"(response to prostaglandin E)|go:"GO:0035094"(response to nicotine)|go:"GO:0035690"|go:"GO:0035902"(response to immobilization stress)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0046847"(filopodium assembly)|go:"GO:0048545"(response to steroid hormone)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051015"(actin filament binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060179"(male mating behavior)|go:"GO:0061458"(reproductive system development)|go:"GO:0071315"(cellular response to morphine)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0097338"(response to clozapine)|go:"GO:1901653"(cellular response to peptide)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903119"(protein localization to actin cytoskeleton)|go:"GO:1904372"(positive regulation of protein localization to actin cortical patch)|go:"GO:1904373"(response to kainic acid)|go:"GO:1904386"(response to L-phenylalanine derivative)|go:"GO:1990778"(protein localization to cell periphery)|go:"GO:1990780"(cytoplasmic side of dendritic spine plasma membrane)|go:"GO:2000474"(regulation of opioid receptor signaling pathway)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR029921|interpro:IPR036034|interpro:IPR040645|interpro:IPR043446|mint:Q96SB3|ensembl:ENSP00000478767|refseq:NP_115984.3 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/05/28 rogid:S8ihl3jxEEyMS46AM2ynXSFfCU49606 rogid:X6fQLpaYhXCqzRlQNEoX67P/HbU9606 intact-crc:FEA84E4597BF2CAC|rigid:5VpwlpQqzlunHNK7tN6q4Wo+lkI false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8TAF3 uniprotkb:Q9UHW5 intact:EBI-1045469|uniprotkb:Q63HJ2|uniprotkb:Q658Y1|uniprotkb:Q8N3Z1|uniprotkb:Q9NSK8|uniprotkb:Q9P279|uniprotkb:B4DM86|uniprotkb:B4DQI2|uniprotkb:B4DY84|ensembl:ENSP00000307491 intact:EBI-395491|uniprotkb:Q53FS3|uniprotkb:Q6UVZ6|uniprotkb:Q7Z3D3|uniprotkb:Q8NEI2|uniprotkb:Q96HK9|uniprotkb:B2RC54|uniprotkb:D4YWV1|ensembl:ENSP00000228827|uniprotkb:F5H759 psi-mi:wdr48_human(display_long)|uniprotkb:WD repeat endosomal protein(gene name synonym)|uniprotkb:p80(gene name synonym)|uniprotkb:WDR48(gene name)|psi-mi:WDR48(display_short)|uniprotkb:KIAA1449(gene name synonym)|uniprotkb:UAF1(gene name synonym)|uniprotkb:USP1-associated factor 1(gene name synonym) psi-mi:gpn3_human(display_long)|uniprotkb:ATPBD1C(gene name synonym)|uniprotkb:ATP-binding domain 1 family member C(gene name synonym)|uniprotkb:GPN3(gene name)|psi-mi:GPN3(display_short)|uniprotkb:AD-009(orf name)|uniprotkb:UNQ1876/PRO4319(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515634|imex:IM-12079-49 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065890.1|ensembl:ENSG00000114742(gene)|ensembl:ENST00000302313(transcript)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0003677"(DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043588"(skin development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0072520"(seminiferous tubule development)|go:"GO:1902525"(regulation of protein monoubiquitination)|go:"GO:1903003"(positive regulation of protein deubiquitination)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR021772|interpro:IPR036322|mint:Q8TAF3|rcsb pdb:5CVL|rcsb pdb:5CVN|rcsb pdb:5CVO|rcsb pdb:5K1A|rcsb pdb:5K1B|rcsb pdb:5K1C|rcsb pdb:5L8E|rcsb pdb:5L8W|rcsb pdb:6JLQ|rcsb pdb:7AY0|rcsb pdb:7AY1|rcsb pdb:7AY2|reactome:R-HSA-110314|reactome:R-HSA-5689880|reactome:R-HSA-6783310|reactome:R-HSA-9673766|refseq:NP_001290331.1|refseq:NP_001290332.1|refseq:NP_001333156.1|refseq:NP_001333157.1|dip:DIP-50841N refseq:NP_001157844.1|refseq:NP_001157845.1|refseq:NP_057385.3|ensembl:ENSG00000111231(gene)|ensembl:ENST00000228827(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0032991"(protein-containing complex)|interpro:IPR004130(Protein of unknown function, ATP binding)|interpro:IPR027417|interpro:IPR030228|mint:Q9UHW5 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/05/28 rogid:S8ihl3jxEEyMS46AM2ynXSFfCU49606 rogid:fKBsnLcvitaM76zQUW+MQXDPxTA9606 intact-crc:FEA84E4597BF2CAC|rigid:5VpwlpQqzlunHNK7tN6q4Wo+lkI false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8TAF3 uniprotkb:O75718 intact:EBI-1045469|uniprotkb:Q63HJ2|uniprotkb:Q658Y1|uniprotkb:Q8N3Z1|uniprotkb:Q9NSK8|uniprotkb:Q9P279|uniprotkb:B4DM86|uniprotkb:B4DQI2|uniprotkb:B4DY84|ensembl:ENSP00000307491 intact:EBI-2515576|ensembl:ENSP00000323696|uniprotkb:B2RBL6 psi-mi:wdr48_human(display_long)|uniprotkb:WD repeat endosomal protein(gene name synonym)|uniprotkb:p80(gene name synonym)|uniprotkb:WDR48(gene name)|psi-mi:WDR48(display_short)|uniprotkb:KIAA1449(gene name synonym)|uniprotkb:UAF1(gene name synonym)|uniprotkb:USP1-associated factor 1(gene name synonym) psi-mi:crtap_human(display_long)|uniprotkb:CRTAP(gene name)|psi-mi:CRTAP(display_short)|uniprotkb:CASP(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515634|imex:IM-12079-49 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065890.1|ensembl:ENSG00000114742(gene)|ensembl:ENST00000302313(transcript)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0003677"(DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043588"(skin development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0072520"(seminiferous tubule development)|go:"GO:1902525"(regulation of protein monoubiquitination)|go:"GO:1903003"(positive regulation of protein deubiquitination)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR021772|interpro:IPR036322|mint:Q8TAF3|rcsb pdb:5CVL|rcsb pdb:5CVN|rcsb pdb:5CVO|rcsb pdb:5K1A|rcsb pdb:5K1B|rcsb pdb:5K1C|rcsb pdb:5L8E|rcsb pdb:5L8W|rcsb pdb:6JLQ|rcsb pdb:7AY0|rcsb pdb:7AY1|rcsb pdb:7AY2|reactome:R-HSA-110314|reactome:R-HSA-5689880|reactome:R-HSA-6783310|reactome:R-HSA-9673766|refseq:NP_001290331.1|refseq:NP_001290332.1|refseq:NP_001333156.1|refseq:NP_001333157.1|dip:DIP-50841N ensembl:ENSG00000170275(gene)|ensembl:ENST00000320954(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0007283"(spermatogenesis)|go:"GO:0018400"(peptidyl-proline hydroxylation to 3-hydroxy-L-proline)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0050821"(protein stabilization)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:1901874"(negative regulation of post-translational protein modification)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR033212|mint:O75718|reactome:R-HSA-1650814|refseq:NP_006362.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/05/28 rogid:S8ihl3jxEEyMS46AM2ynXSFfCU49606 rogid:7rtGL+UxGVyDTmnJagIzXaUziIw9606 intact-crc:FEA84E4597BF2CAC|rigid:5VpwlpQqzlunHNK7tN6q4Wo+lkI false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8TAF3 uniprotkb:P18615 intact:EBI-1045469|uniprotkb:Q63HJ2|uniprotkb:Q658Y1|uniprotkb:Q8N3Z1|uniprotkb:Q9NSK8|uniprotkb:Q9P279|uniprotkb:B4DM86|uniprotkb:B4DQI2|uniprotkb:B4DY84|ensembl:ENSP00000307491 intact:EBI-348444|uniprotkb:B4DUN1|uniprotkb:B4DYX9|ensembl:ENSP00000364578|ensembl:ENSP00000372660|ensembl:ENSP00000372834|ensembl:ENSP00000393005|ensembl:ENSP00000394879|ensembl:ENSP00000403623|uniprotkb:Q5JP74|uniprotkb:Q5JP75|uniprotkb:Q96F56|uniprotkb:Q9NPK2|uniprotkb:A2BE08 psi-mi:wdr48_human(display_long)|uniprotkb:WD repeat endosomal protein(gene name synonym)|uniprotkb:p80(gene name synonym)|uniprotkb:WDR48(gene name)|psi-mi:WDR48(display_short)|uniprotkb:KIAA1449(gene name synonym)|uniprotkb:UAF1(gene name synonym)|uniprotkb:USP1-associated factor 1(gene name synonym) psi-mi:nelfe_human(display_long)|uniprotkb:NELFE(gene name)|psi-mi:NELFE(display_short)|uniprotkb:RD(gene name synonym)|uniprotkb:RDBP(gene name synonym)|uniprotkb:RNA-binding protein RD(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515634|imex:IM-12079-49 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065890.1|ensembl:ENSG00000114742(gene)|ensembl:ENST00000302313(transcript)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0003677"(DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043588"(skin development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0072520"(seminiferous tubule development)|go:"GO:1902525"(regulation of protein monoubiquitination)|go:"GO:1903003"(positive regulation of protein deubiquitination)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR021772|interpro:IPR036322|mint:Q8TAF3|rcsb pdb:5CVL|rcsb pdb:5CVN|rcsb pdb:5CVO|rcsb pdb:5K1A|rcsb pdb:5K1B|rcsb pdb:5K1C|rcsb pdb:5L8E|rcsb pdb:5L8W|rcsb pdb:6JLQ|rcsb pdb:7AY0|rcsb pdb:7AY1|rcsb pdb:7AY2|reactome:R-HSA-110314|reactome:R-HSA-5689880|reactome:R-HSA-6783310|reactome:R-HSA-9673766|refseq:NP_001290331.1|refseq:NP_001290332.1|refseq:NP_001333156.1|refseq:NP_001333157.1|dip:DIP-50841N refseq:NP_002895.3|ensembl:ENSG00000204356(gene)|ensembl:ENSG00000206268(gene)|ensembl:ENSG00000206357(gene)|ensembl:ENSG00000229363(gene)|ensembl:ENSG00000231044(gene)|ensembl:ENSG00000233801(gene)|ensembl:ENST00000375429(transcript)|ensembl:ENST00000383174(transcript)|ensembl:ENST00000383343(transcript)|ensembl:ENST00000429857(transcript)|ensembl:ENST00000448628(transcript)|ensembl:ENST00000457397(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0032021"(NELF complex)|go:"GO:0005634"(nucleus)|go:"GO:0034244"(negative regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:1900364"(negative regulation of mRNA polyadenylation)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR033102|interpro:IPR034637|interpro:IPR035979|mint:P18615|rcsb pdb:1X5P|rcsb pdb:2BZ2|rcsb pdb:2JX2|rcsb pdb:5OOB|rcsb pdb:6GML|reactome:R-HSA-112382|reactome:R-HSA-113418|reactome:R-HSA-167152|reactome:R-HSA-167158|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167242|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-674695|reactome:R-HSA-6796648|reactome:R-HSA-75955|dip:DIP-32669N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/05/28 rogid:S8ihl3jxEEyMS46AM2ynXSFfCU49606 rogid:AaBoPxRk9kFoijQiehOZtEZ+/OI9606 intact-crc:FEA84E4597BF2CAC|rigid:5VpwlpQqzlunHNK7tN6q4Wo+lkI false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8TAF3 uniprotkb:Q14191 intact:EBI-1045469|uniprotkb:Q63HJ2|uniprotkb:Q658Y1|uniprotkb:Q8N3Z1|uniprotkb:Q9NSK8|uniprotkb:Q9P279|uniprotkb:B4DM86|uniprotkb:B4DQI2|uniprotkb:B4DY84|ensembl:ENSP00000307491 intact:EBI-368417|uniprotkb:A1KYY9|ensembl:ENSP00000298139 psi-mi:wdr48_human(display_long)|uniprotkb:WD repeat endosomal protein(gene name synonym)|uniprotkb:p80(gene name synonym)|uniprotkb:WDR48(gene name)|psi-mi:WDR48(display_short)|uniprotkb:KIAA1449(gene name synonym)|uniprotkb:UAF1(gene name synonym)|uniprotkb:USP1-associated factor 1(gene name synonym) psi-mi:wrn_human(display_long)|uniprotkb:WRN(gene name)|psi-mi:WRN(display_short)|uniprotkb:RECQ3(gene name synonym)|uniprotkb:RECQL2(gene name synonym)|uniprotkb:Exonuclease WRN(gene name synonym)|uniprotkb:RecQ protein-like 2(gene name synonym)|uniprotkb:DNA helicase, RecQ-like type 3(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515634|imex:IM-12079-49 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065890.1|ensembl:ENSG00000114742(gene)|ensembl:ENST00000302313(transcript)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0003677"(DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043588"(skin development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0072520"(seminiferous tubule development)|go:"GO:1902525"(regulation of protein monoubiquitination)|go:"GO:1903003"(positive regulation of protein deubiquitination)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR021772|interpro:IPR036322|mint:Q8TAF3|rcsb pdb:5CVL|rcsb pdb:5CVN|rcsb pdb:5CVO|rcsb pdb:5K1A|rcsb pdb:5K1B|rcsb pdb:5K1C|rcsb pdb:5L8E|rcsb pdb:5L8W|rcsb pdb:6JLQ|rcsb pdb:7AY0|rcsb pdb:7AY1|rcsb pdb:7AY2|reactome:R-HSA-110314|reactome:R-HSA-5689880|reactome:R-HSA-6783310|reactome:R-HSA-9673766|refseq:NP_001290331.1|refseq:NP_001290332.1|refseq:NP_001333156.1|refseq:NP_001333157.1|dip:DIP-50841N refseq:NP_000544.2|go:"GO:0061820"(telomeric D-loop disassembly)|go:"GO:0061821"(telomeric D-loop binding)|go:"GO:0061849"(telomeric G-quadruplex DNA binding)|go:"GO:0070337"(3'-flap-structured DNA binding)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0090399"(replicative senescence)|go:"GO:0090656"(t-circle formation)|go:"GO:0098530"(positive regulation of strand invasion)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1902570"(protein localization to nucleolus)|go:"GO:1905773"(8-hydroxy-2'-deoxyguanosine DNA binding)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR002121(Helicase and RNase D C-terminal, HRDC)|interpro:IPR002562(3'-5' exonuclease)|interpro:IPR004589(DNA helicase, ATP-dependent, RecQ type)|interpro:IPR010997(HRDC-like)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR018982|interpro:IPR027417|interpro:IPR029491|interpro:IPR032284|interpro:IPR036388|interpro:IPR036390|interpro:IPR036397|mint:Q14191|rcsb pdb:2AXL|rcsb pdb:2DGZ|rcsb pdb:2E1E|rcsb pdb:2E1F|rcsb pdb:2FBT|rcsb pdb:2FBV|rcsb pdb:2FBX|go:"GO:0061749"(forked DNA-dependent helicase activity)|rcsb pdb:2FBY|rcsb pdb:3AAF|rcsb pdb:6TYV|rcsb pdb:6YHR|reactome:R-HSA-174414|reactome:R-HSA-174437|reactome:R-HSA-3108214|reactome:R-HSA-5685938|reactome:R-HSA-5685942|reactome:R-HSA-5693554|reactome:R-HSA-5693568|reactome:R-HSA-5693579|reactome:R-HSA-5693607|reactome:R-HSA-5693616|reactome:R-HSA-6804756|reactome:R-HSA-69473|rcsb pdb:2FC0|ensembl:ENSG00000165392(gene)|ensembl:ENST00000298139(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000400"(four-way junction DNA binding)|go:"GO:0000403"(Y-form DNA binding)|go:"GO:0000405"(bubble DNA binding)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000731"(DNA synthesis involved in DNA repair)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003677"(DNA binding)|go:"GO:0003678"(DNA helicase activity)|go:"GO:0003682"(chromatin binding)|go:"GO:0004527"(exonuclease activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005694"(chromosome)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007420"(brain development)|go:"GO:0007568"(aging)|go:"GO:0007569"(cell aging)|go:"GO:0008408"(3'-5' exonuclease activity)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009378"(four-way junction helicase activity)|go:"GO:0010225"(response to UV-C)|go:"GO:0010259"(multicellular organism aging)|go:"GO:0016607"(nuclear speck)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031297"(replication fork processing)|go:"GO:0005730"(nucleolus)|go:"GO:0032201"(telomere maintenance via semi-conservative replication)|go:"GO:0032405"(MutLalpha complex binding)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0040009"(regulation of growth rate)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043138"(3'-5' DNA helicase activity)|go:"GO:0005813"(centrosome)|go:"GO:0006259"(DNA metabolic process)|go:"GO:0006260"(DNA replication)|go:"GO:0044806"(G-quadruplex DNA unwinding)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0051345"(positive regulation of hydrolase activity)|go:"GO:0051880"(G-quadruplex DNA binding)|go:"GO:0006281"(DNA repair)|go:"GO:0006284"(base-excision repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006310"(DNA recombination)|dip:DIP-31380N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/05/28 rogid:S8ihl3jxEEyMS46AM2ynXSFfCU49606 rogid:AKmM4xnux0/lA9uEzk7yvug/Wng9606 intact-crc:FEA84E4597BF2CAC|rigid:5VpwlpQqzlunHNK7tN6q4Wo+lkI false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8TAF3 uniprotkb:Q9ULJ8 intact:EBI-1045469|uniprotkb:Q63HJ2|uniprotkb:Q658Y1|uniprotkb:Q8N3Z1|uniprotkb:Q9NSK8|uniprotkb:Q9P279|uniprotkb:B4DM86|uniprotkb:B4DQI2|uniprotkb:B4DY84|ensembl:ENSP00000307491 intact:EBI-2515561|ensembl:ENSP00000344524|ensembl:ENSP00000398870|uniprotkb:O76059|uniprotkb:Q9NXT2|uniprotkb:F8W7J9|uniprotkb:A1L494|uniprotkb:B2RWQ1|uniprotkb:E9PCA0|uniprotkb:E9PCK6|uniprotkb:E9PDX1|intact:EBI-11031420 psi-mi:wdr48_human(display_long)|uniprotkb:WD repeat endosomal protein(gene name synonym)|uniprotkb:p80(gene name synonym)|uniprotkb:WDR48(gene name)|psi-mi:WDR48(display_short)|uniprotkb:KIAA1449(gene name synonym)|uniprotkb:UAF1(gene name synonym)|uniprotkb:USP1-associated factor 1(gene name synonym) psi-mi:neb1_human(display_long)|uniprotkb:PPP1R9A(gene name)|psi-mi:PPP1R9A(display_short)|uniprotkb:KIAA1222(gene name synonym)|uniprotkb:Neurabin-I(gene name synonym)|uniprotkb:Neural tissue-specific F-actin-binding protein I(gene name synonym)|uniprotkb:Protein phosphatase 1 regulatory subunit 9A(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515634|imex:IM-12079-49 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065890.1|ensembl:ENSG00000114742(gene)|ensembl:ENST00000302313(transcript)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0003677"(DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043588"(skin development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0072520"(seminiferous tubule development)|go:"GO:1902525"(regulation of protein monoubiquitination)|go:"GO:1903003"(positive regulation of protein deubiquitination)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR021772|interpro:IPR036322|mint:Q8TAF3|rcsb pdb:5CVL|rcsb pdb:5CVN|rcsb pdb:5CVO|rcsb pdb:5K1A|rcsb pdb:5K1B|rcsb pdb:5K1C|rcsb pdb:5L8E|rcsb pdb:5L8W|rcsb pdb:6JLQ|rcsb pdb:7AY0|rcsb pdb:7AY1|rcsb pdb:7AY2|reactome:R-HSA-110314|reactome:R-HSA-5689880|reactome:R-HSA-6783310|reactome:R-HSA-9673766|refseq:NP_001290331.1|refseq:NP_001290332.1|refseq:NP_001333156.1|refseq:NP_001333157.1|dip:DIP-50841N ensembl:ENSG00000158528(gene)|ensembl:ENST00000340694(transcript)|ensembl:ENST00000433881(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007015"(actin filament organization)|go:"GO:0007568"(aging)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008157"(protein phosphatase 1 binding)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030175"(filopodium)|go:"GO:0030425"(dendrite)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031175"(neuron projection development)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0051015"(actin filament binding)|go:"GO:0051020"(GTPase binding)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0051823"(regulation of synapse structural plasticity)|go:"GO:0051963"(regulation of synapse assembly)|go:"GO:0060079"(excitatory postsynaptic potential)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0097237"(cellular response to toxic substance)|go:"GO:0098871"(postsynaptic actin cytoskeleton)|go:"GO:0098974"(postsynaptic actin cytoskeleton organization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1904049"(negative regulation of spontaneous neurotransmitter secretion)|go:"GO:1990761"(growth cone lamellipodium)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001660(Sterile alpha motif SAM)|go:"GO:0019901"(protein kinase binding)|interpro:IPR029994|interpro:IPR036034|interpro:IPR040645|interpro:IPR043446|mint:Q9ULJ8|rcsb pdb:1WF8|interpro:IPR013761(Sterile alpha motif-type)|refseq:XP_016867892.1|refseq:XP_016867894.1|refseq:XP_016867895.1|refseq:NP_001159632.1|refseq:NP_001159633.1|refseq:NP_001159634.1|refseq:NP_060120.2|refseq:NP_001159635.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/05/28 rogid:S8ihl3jxEEyMS46AM2ynXSFfCU49606 rogid:WoKc99IJ5LLtXFS0vmzxpg8CgHc9606 intact-crc:FEA84E4597BF2CAC|rigid:5VpwlpQqzlunHNK7tN6q4Wo+lkI false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8TAF3 uniprotkb:Q6ZVD8 intact:EBI-1045469|uniprotkb:Q63HJ2|uniprotkb:Q658Y1|uniprotkb:Q8N3Z1|uniprotkb:Q9NSK8|uniprotkb:Q9P279|uniprotkb:B4DM86|uniprotkb:B4DQI2|uniprotkb:B4DY84|ensembl:ENSP00000307491 intact:EBI-2511496|uniprotkb:Q9NV17|uniprotkb:Q9Y2E3|uniprotkb:A1L374|ensembl:ENSP00000457991 psi-mi:wdr48_human(display_long)|uniprotkb:WD repeat endosomal protein(gene name synonym)|uniprotkb:p80(gene name synonym)|uniprotkb:WDR48(gene name)|psi-mi:WDR48(display_short)|uniprotkb:KIAA1449(gene name synonym)|uniprotkb:UAF1(gene name synonym)|uniprotkb:USP1-associated factor 1(gene name synonym) psi-mi:phlp2_human(display_long)|uniprotkb:PHLPP2(gene name)|psi-mi:PHLPP2(display_short)|uniprotkb:KIAA0931(gene name synonym)|uniprotkb:PHLPPL(gene name synonym)|uniprotkb:PH domain leucine-rich repeat-containing protein phosphatase-like(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515634|imex:IM-12079-49 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065890.1|ensembl:ENSG00000114742(gene)|ensembl:ENST00000302313(transcript)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0003677"(DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043588"(skin development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0072520"(seminiferous tubule development)|go:"GO:1902525"(regulation of protein monoubiquitination)|go:"GO:1903003"(positive regulation of protein deubiquitination)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR021772|interpro:IPR036322|mint:Q8TAF3|rcsb pdb:5CVL|rcsb pdb:5CVN|rcsb pdb:5CVO|rcsb pdb:5K1A|rcsb pdb:5K1B|rcsb pdb:5K1C|rcsb pdb:5L8E|rcsb pdb:5L8W|rcsb pdb:6JLQ|rcsb pdb:7AY0|rcsb pdb:7AY1|rcsb pdb:7AY2|reactome:R-HSA-110314|reactome:R-HSA-5689880|reactome:R-HSA-6783310|reactome:R-HSA-9673766|refseq:NP_001290331.1|refseq:NP_001290332.1|refseq:NP_001333156.1|refseq:NP_001333157.1|dip:DIP-50841N refseq:NP_001275932.1|refseq:NP_055835.2|dip:DIP-53556N|ensembl:ENSG00000040199(gene)|ensembl:ENST00000568954(transcript)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0021766"(hippocampus development)|go:"GO:0042622"(photoreceptor outer segment membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045171"(intercellular bridge)|go:"GO:0046872"(metal ion binding)|go:"GO:0072686"(mitotic spindle)|go:"GO:0106306"|go:"GO:0106307"|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR001932(Protein phosphatase 2C-related)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR032675|interpro:IPR036457|reactome:R-HSA-199418 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/05/28 rogid:S8ihl3jxEEyMS46AM2ynXSFfCU49606 rogid:Z6e8RRJ8TleJRWTlecN3DNu1Ums9606 intact-crc:FEA84E4597BF2CAC|rigid:5VpwlpQqzlunHNK7tN6q4Wo+lkI false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8TAF3 uniprotkb:Q7KZ85 intact:EBI-1045469|uniprotkb:Q63HJ2|uniprotkb:Q658Y1|uniprotkb:Q8N3Z1|uniprotkb:Q9NSK8|uniprotkb:Q9P279|uniprotkb:B4DM86|uniprotkb:B4DQI2|uniprotkb:B4DY84|ensembl:ENSP00000307491 intact:EBI-2515547|ensembl:ENSP00000319104|ensembl:ENSP00000338143|uniprotkb:Q96AH3|uniprotkb:Q7KYW9|uniprotkb:Q6GMQ4|uniprotkb:Q8N526|uniprotkb:Q15737|uniprotkb:Q9BTI2|uniprotkb:Q92775|uniprotkb:Q9BTH9|uniprotkb:Q7LDK4|uniprotkb:A7E2B4 psi-mi:wdr48_human(display_long)|uniprotkb:WD repeat endosomal protein(gene name synonym)|uniprotkb:p80(gene name synonym)|uniprotkb:WDR48(gene name)|psi-mi:WDR48(display_short)|uniprotkb:KIAA1449(gene name synonym)|uniprotkb:UAF1(gene name synonym)|uniprotkb:USP1-associated factor 1(gene name synonym) psi-mi:spt6h_human(display_long)|uniprotkb:SUPT6H(gene name)|psi-mi:SUPT6H(display_short)|uniprotkb:KIAA0162(gene name synonym)|uniprotkb:SPT6H(gene name synonym)|uniprotkb:Tat-cotransactivator 2 protein(gene name synonym)|uniprotkb:Histone chaperone suppressor of Ty6(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515634|imex:IM-12079-49 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065890.1|ensembl:ENSG00000114742(gene)|ensembl:ENST00000302313(transcript)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0003677"(DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043588"(skin development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0072520"(seminiferous tubule development)|go:"GO:1902525"(regulation of protein monoubiquitination)|go:"GO:1903003"(positive regulation of protein deubiquitination)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR021772|interpro:IPR036322|mint:Q8TAF3|rcsb pdb:5CVL|rcsb pdb:5CVN|rcsb pdb:5CVO|rcsb pdb:5K1A|rcsb pdb:5K1B|rcsb pdb:5K1C|rcsb pdb:5L8E|rcsb pdb:5L8W|rcsb pdb:6JLQ|rcsb pdb:7AY0|rcsb pdb:7AY1|rcsb pdb:7AY2|reactome:R-HSA-110314|reactome:R-HSA-5689880|reactome:R-HSA-6783310|reactome:R-HSA-9673766|refseq:NP_001290331.1|refseq:NP_001290332.1|refseq:NP_001333156.1|refseq:NP_001333157.1|dip:DIP-50841N go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0006397"(mRNA processing)|go:"GO:0008023"(transcription elongation factor complex)|go:"GO:0008380"(RNA splicing)|go:"GO:0010793"(regulation of mRNA export from nucleus)|go:"GO:0031491"(nucleosome binding)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0034728"(nucleosome organization)|go:"GO:0035327"|go:"GO:0042393"(histone binding)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0045191"(regulation of isotype switching)|go:"GO:0050684"(regulation of mRNA processing)|go:"GO:0051028"(mRNA transport)|go:"GO:0051147"(regulation of muscle cell differentiation)|go:"GO:0061086"(negative regulation of histone H3-K27 methylation)|go:"GO:0070827"(obsolete chromatin maintenance)|interpro:IPR000980(SH2 motif)|interpro:IPR003029(S1, RNA binding)|interpro:IPR006641(Resolvase, RNase H-like fold)|interpro:IPR010994(RuvA domain 2-like)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR017072(Transcription elongation factor Spt6)|interpro:IPR022967|interpro:IPR023319|interpro:IPR028083|interpro:IPR028088|interpro:IPR028231|interpro:IPR032706|interpro:IPR035018|interpro:IPR035019|interpro:IPR035420|interpro:IPR036860|interpro:IPR037027|interpro:IPR041692|interpro:IPR042066|mint:Q7KZ85|rcsb pdb:6GME|rcsb pdb:6GMH|rcsb pdb:6TED|reactome:R-HSA-112382|reactome:R-HSA-674695|reactome:R-HSA-75955|interpro:IPR023323|ensembl:ENSG00000109111(gene)|ensembl:ENST00000314616(transcript)|ensembl:ENST00000347486(transcript)|go:"GO:0001825"(blastocyst formation)|refseq:XP_016880467.1|refseq:XP_016880468.1|refseq:XP_016880469.1|refseq:NP_003161.2|refseq:NP_001307684.1|dip:DIP-42615N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/05/28 rogid:S8ihl3jxEEyMS46AM2ynXSFfCU49606 rogid:G1HKe2xEnti5tcZvbH4uqLOwKNg9606 intact-crc:FEA84E4597BF2CAC|rigid:5VpwlpQqzlunHNK7tN6q4Wo+lkI false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q8TAF3 uniprotkb:P04637 intact:EBI-1045469|uniprotkb:Q63HJ2|uniprotkb:Q658Y1|uniprotkb:Q8N3Z1|uniprotkb:Q9NSK8|uniprotkb:Q9P279|uniprotkb:B4DM86|uniprotkb:B4DQI2|uniprotkb:B4DY84|ensembl:ENSP00000307491 intact:EBI-366083|uniprotkb:Q15086|uniprotkb:Q15087|uniprotkb:Q15088|uniprotkb:Q16535|uniprotkb:Q16807|uniprotkb:Q16808|uniprotkb:Q16809|uniprotkb:Q16810|uniprotkb:Q16811|uniprotkb:Q16848|uniprotkb:Q86UG1|uniprotkb:Q8J016|uniprotkb:Q99659|uniprotkb:Q9BTM4|uniprotkb:Q9HAQ8|uniprotkb:Q9NP68|uniprotkb:Q9NPJ2|uniprotkb:Q9NZD0|uniprotkb:Q9UBI2|uniprotkb:Q9UQ61|ensembl:ENSP00000269305|ensembl:ENSP00000391478|intact:EBI-28980681|uniprotkb:Q2XN98|uniprotkb:Q3LRW1|uniprotkb:Q3LRW2|uniprotkb:Q3LRW3|uniprotkb:Q3LRW4|uniprotkb:Q3LRW5 psi-mi:wdr48_human(display_long)|uniprotkb:WD repeat endosomal protein(gene name synonym)|uniprotkb:p80(gene name synonym)|uniprotkb:WDR48(gene name)|psi-mi:WDR48(display_short)|uniprotkb:KIAA1449(gene name synonym)|uniprotkb:UAF1(gene name synonym)|uniprotkb:USP1-associated factor 1(gene name synonym) psi-mi:p53_human(display_long)|uniprotkb:TP53(gene name)|psi-mi:TP53(display_short)|uniprotkb:P53(gene name synonym)|uniprotkb:Tumor suppressor p53(gene name synonym)|uniprotkb:Phosphoprotein p53(gene name synonym)|uniprotkb:Antigen NY-CO-13(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515634|imex:IM-12079-49 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_065890.1|ensembl:ENSG00000114742(gene)|ensembl:ENST00000302313(transcript)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0003677"(DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043588"(skin development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0072520"(seminiferous tubule development)|go:"GO:1902525"(regulation of protein monoubiquitination)|go:"GO:1903003"(positive regulation of protein deubiquitination)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR021772|interpro:IPR036322|mint:Q8TAF3|rcsb pdb:5CVL|rcsb pdb:5CVN|rcsb pdb:5CVO|rcsb pdb:5K1A|rcsb pdb:5K1B|rcsb pdb:5K1C|rcsb pdb:5L8E|rcsb pdb:5L8W|rcsb pdb:6JLQ|rcsb pdb:7AY0|rcsb pdb:7AY1|rcsb pdb:7AY2|reactome:R-HSA-110314|reactome:R-HSA-5689880|reactome:R-HSA-6783310|reactome:R-HSA-9673766|refseq:NP_001290331.1|refseq:NP_001290332.1|refseq:NP_001333156.1|refseq:NP_001333157.1|dip:DIP-50841N refseq:NP_001263624.1|refseq:NP_001263625.1|ensembl:ENSG00000141510(gene)|ensembl:ENST00000269305(transcript)|ensembl:ENST00000445888(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0001094"(TFIID-class transcription factor complex binding)|go:"GO:0001216"(DNA-binding transcription activator activity)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001756"(somitogenesis)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0002020"(protease binding)|go:"GO:0002039"(p53 binding)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002309"(T cell proliferation involved in immune response)|go:"GO:0002360"(T cell lineage commitment)|go:"GO:0002326"(B cell lineage commitment)|go:"GO:0031497"(chromatin assembly)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034103"(regulation of tissue remodeling)|go:"GO:0034613"(cellular protein localization)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035033"(histone deacetylase regulator activity)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035690"|go:"GO:0035794"(positive regulation of mitochondrial membrane permeability)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036003"(positive regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0036310"(ATP-dependent DNA/DNA annealing activity)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0002931"(response to ischemia)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006914"(autophagy)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006977"(DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)|go:"GO:0006978"(DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator)|go:"GO:0006983"(ER overload response)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007369"(gastrulation)|go:"GO:0007406"(negative regulation of neuroblast proliferation)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0043504"(mitochondrial DNA repair)|go:"GO:0043516"(regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0043621"(protein self-association)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045899"(positive regulation of RNA polymerase II transcription preinitiation complex assembly)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0048512"(circadian behavior)|go:"GO:0048539"(bone marrow development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051097"(negative regulation of helicase activity)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0062100"(positive regulation of programmed necrotic cell death)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0060411"(cardiac septum morphogenesis)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070245"(positive regulation of thymocyte apoptotic process)|go:"GO:0070266"(necroptotic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0071494"(cellular response to UV-C)|go:"GO:0072331"(signal transduction by p53 class mediator)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0072717"(cellular response to actinomycin D)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0090343"(positive regulation of cell aging)|go:"GO:0090399"(replicative senescence)|go:"GO:0090403"(oxidative stress-induced premature senescence)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0097252"(oligodendrocyte apoptotic process)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0140296"(general transcription initiation factor binding)|go:"GO:1900119"(positive regulation of execution phase of apoptosis)|go:"GO:1901525"(negative regulation of mitophagy)|go:"GO:1902108"(regulation of mitochondrial membrane permeability involved in apoptotic process)|go:"GO:1902253"(regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904024"(negative regulation of glucose catabolic process to lactate via pyruvate)|go:"GO:1905856"(negative regulation of pentose-phosphate shunt)|go:"GO:1990144"(intrinsic apoptotic signaling pathway in response to hypoxia)|go:"GO:1990248"(regulation of transcription from RNA polymerase II promoter in response to DNA damage)|go:"GO:1990440"(positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000269"(regulation of fibroblast apoptotic process)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000772"(regulation of cellular senescence)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002117(p53 tumor antigen)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR010991(p53, tetramerisation)|interpro:IPR011615(p53, DNA-binding)|go:"GO:0007569"(cell aging)|go:"GO:0008104"(protein localization)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008156"(negative regulation of DNA replication)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009299"(mRNA transcription)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009651"(response to salt stress)|go:"GO:0010165"(response to X-ray)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0016032"(viral process)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016605"(PML body)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031065"(positive regulation of histone deacetylation)|interpro:IPR012346(p53 and RUNT-type transcription factor, DNA-binding)|interpro:IPR013872("p53 transactivation domain (TAD)")|interpro:IPR036674|interpro:IPR040926|rcsb pdb:2ATA|rcsb pdb:2B3G|rcsb pdb:2BIM|rcsb pdb:2BIN|rcsb pdb:2BIO|rcsb pdb:2BIP|rcsb pdb:2AHI|rcsb pdb:2BIQ|rcsb pdb:2F1X|rcsb pdb:2FEJ|rcsb pdb:2FOJ|rcsb pdb:2FOO|rcsb pdb:2GS0|rcsb pdb:2H1L|rcsb pdb:2H2D|rcsb pdb:2H2F|rcsb pdb:2H4F|rcsb pdb:2H4H|rcsb pdb:2H4J|rcsb pdb:2H59|rcsb pdb:2J0Z|rcsb pdb:2J10|rcsb pdb:2J11|rcsb pdb:2J1W|rcsb pdb:2J1X|rcsb pdb:2J1Y|rcsb pdb:2J1Z|rcsb pdb:2J20|rcsb pdb:2J21|rcsb pdb:2K8F|rcsb pdb:2L14|rcsb pdb:2LY4|rcsb pdb:2MEJ|rcsb pdb:2MWO|rcsb pdb:2MWP|rcsb pdb:2MWY|rcsb pdb:2MZD|rcsb pdb:2OCJ|rcsb pdb:2PCX|rcsb pdb:1A1U|rcsb pdb:1AIE|rcsb pdb:1C26|rcsb pdb:1DT7|rcsb pdb:1GZH|rcsb pdb:1H26|rcsb pdb:1HS5|rcsb pdb:1JSP|rcsb pdb:1KZY|rcsb pdb:1MA3|rcsb pdb:1OLG|rcsb pdb:1OLH|rcsb pdb:1PES|rcsb pdb:1PET|mint:P04637|rcsb pdb:1SAE|rcsb pdb:1SAF|rcsb pdb:1SAK|rcsb pdb:1SAL|rcsb pdb:1TSR|rcsb pdb:1TUP|rcsb pdb:1UOL|rcsb pdb:1XQH|rcsb pdb:1YC5|rcsb pdb:1YCQ|rcsb pdb:1YCR|rcsb pdb:1YCS|rcsb pdb:2AC0|rcsb pdb:2ADY|refseq:NP_000537.3|refseq:NP_001119584.1|refseq:NP_001119585.1|refseq:NP_001119586.1|refseq:NP_001119587.1|refseq:NP_001119588.1|refseq:NP_001119589.1|rcsb pdb:2RUK|rcsb pdb:2VUK|rcsb pdb:3Q06|rcsb pdb:2WGX|rcsb pdb:2X0U|rcsb pdb:2X0V|rcsb pdb:2X0W|rcsb pdb:2XWR|rcsb pdb:2YBG|rcsb pdb:2YDR|rcsb pdb:2Z5S|rcsb pdb:2Z5T|rcsb pdb:3SAK|rcsb pdb:3D05|rcsb pdb:3D06|rcsb pdb:3D07|rcsb pdb:3D08|rcsb pdb:3D09|rcsb pdb:3D0A|rcsb pdb:3DAB|rcsb pdb:3DAC|rcsb pdb:3IGK|rcsb pdb:3IGL|rcsb pdb:3KMD|rcsb pdb:3TG5|rcsb pdb:3KZ8|rcsb pdb:3LW1|rcsb pdb:3OQ5|rcsb pdb:3PDH|rcsb pdb:3Q01|rcsb pdb:3Q05|rcsb pdb:3TS8|rcsb pdb:3ZME|rcsb pdb:4AGM|rcsb pdb:4AGN|rcsb pdb:4AGO|rcsb pdb:4AGP|rcsb pdb:4AGQ|rcsb pdb:4BUZ|rcsb pdb:4BV2|rcsb pdb:4HFZ|rcsb pdb:4HJE|rcsb pdb:4IBQ|rcsb pdb:4IBS|rcsb pdb:4IBT|rcsb pdb:4IBU|rcsb pdb:4IBV|rcsb pdb:4IBW|rcsb pdb:4IBY|rcsb pdb:4IBZ|rcsb pdb:4IJT|rcsb pdb:4KVP|rcsb pdb:4LO9|rcsb pdb:4LOE|rcsb pdb:4LOF|rcsb pdb:4MZI|rcsb pdb:4MZR|rcsb pdb:4QO1|rcsb pdb:4RP6|rcsb pdb:4RP7|rcsb pdb:4X34|rcsb pdb:4XR8|rcsb pdb:4ZZJ|rcsb pdb:5A7B|rcsb pdb:5AB9|rcsb pdb:5ABA|rcsb pdb:4AGL|rcsb pdb:5AOI|rcsb pdb:5AOJ|rcsb pdb:5AOK|rcsb pdb:5AOL|rcsb pdb:5AOM|rcsb pdb:6XRE|rcsb pdb:7BWN|rcsb pdb:7DHY|rcsb pdb:7DHZ|rcsb pdb:7EL4|reactome:R-HSA-111448|reactome:R-HSA-139915|reactome:R-HSA-1912408|reactome:R-HSA-2559580|reactome:R-HSA-2559584|reactome:R-HSA-2559585|reactome:R-HSA-2559586|reactome:R-HSA-3232118|reactome:R-HSA-349425|reactome:R-HSA-390471|reactome:R-HSA-5620971|reactome:R-HSA-5628897|reactome:R-HSA-5689880|reactome:R-HSA-5689896|reactome:R-HSA-5693565|reactome:R-HSA-6785807|reactome:R-HSA-6796648|reactome:R-HSA-6803204|reactome:R-HSA-6803205|reactome:R-HSA-6803207|reactome:R-HSA-6803211|reactome:R-HSA-6804114|reactome:R-HSA-6804115|reactome:R-HSA-6804116|reactome:R-HSA-6804754|reactome:R-HSA-6804756|reactome:R-HSA-6804757|reactome:R-HSA-6804758|reactome:R-HSA-6804759|reactome:R-HSA-6804760|reactome:R-HSA-6811555|reactome:R-HSA-69473|reactome:R-HSA-69481|reactome:R-HSA-69541|reactome:R-HSA-69895|reactome:R-HSA-8852276|reactome:R-HSA-8853884|reactome:R-HSA-8941855|reactome:R-HSA-8943724|reactome:R-HSA-983231|rcsb pdb:5ECG|rcsb pdb:5G4M|rcsb pdb:5G4N|rcsb pdb:5BUA|rcsb pdb:5G4O|rcsb pdb:5HOU|rcsb pdb:5HP0|rcsb pdb:5HPD|rcsb pdb:5LAP|rcsb pdb:5LGY|rcsb pdb:5MCT|rcsb pdb:5MCU|rcsb pdb:5MCV|rcsb pdb:5MCW|rcsb pdb:5MF7|rcsb pdb:5MG7|rcsb pdb:5MHC|rcsb pdb:5MOC|rcsb pdb:5O1A|rcsb pdb:5O1B|rcsb pdb:5O1C|rcsb pdb:5O1D|rcsb pdb:5O1E|rcsb pdb:5O1F|rcsb pdb:5O1G|rcsb pdb:5O1H|rcsb pdb:5O1I|rcsb pdb:5OL0|rcsb pdb:5UN8|rcsb pdb:5XZC|rcsb pdb:6FF9|rcsb pdb:6FJ5|rcsb pdb:6GGA|rcsb pdb:6GGB|rcsb pdb:6GGC|rcsb pdb:6GGD|rcsb pdb:6GGE|rcsb pdb:6GGF|rcsb pdb:6LHD|rcsb pdb:6R5L|rcsb pdb:6RJZ|rcsb pdb:6RK8|rcsb pdb:6RKI|rcsb pdb:6RKK|rcsb pdb:6RKM|rcsb pdb:6RL3|rcsb pdb:6RL4|rcsb pdb:6RL6|rcsb pdb:6RM5|rcsb pdb:6RM7|rcsb pdb:6RWH|rcsb pdb:6RWI|rcsb pdb:6RWS|rcsb pdb:6RWU|rcsb pdb:6RX2|rcsb pdb:6RZ3|rcsb pdb:6S39|rcsb pdb:6S40|rcsb pdb:6S9Q|rcsb pdb:6SHZ|rcsb pdb:6SI0|rcsb pdb:6SI1|rcsb pdb:6SI2|rcsb pdb:6SI3|rcsb pdb:6SI4|rcsb pdb:6SIN|rcsb pdb:6SIO|rcsb pdb:6SIP|rcsb pdb:6SIQ|rcsb pdb:6SL6|rcsb pdb:6SLV|rcsb pdb:6T58|rcsb pdb:6V4F|rcsb pdb:6V4H|rcsb pdb:6VQO|rcsb pdb:6VR1|rcsb pdb:6VR5|rcsb pdb:6VRM|rcsb pdb:6VRN|rcsb pdb:6W51|rcsb pdb:6S3C|ensembl:ENSP00000269305|ensembl:ENST00000420246|ensembl:ENSP00000391127|ensembl:ENSP00000391478|ensembl:ENST00000455263|ensembl:ENSP00000398846|ensembl:ENST00000504290|ensembl:ENSP00000484409|ensembl:ENST00000504937|ensembl:ENSP00000481179|ensembl:ENST00000510385|ensembl:ENSP00000478499|ensembl:ENST00000610292|ensembl:ENSP00000478219|ensembl:ENST00000610538|ensembl:ENSP00000480868|ensembl:ENST00000619485|ensembl:ENSP00000482537|ensembl:ENST00000620739|ensembl:ENSP00000481638|ensembl:ENST00000622645|ensembl:ENSP00000482222|refseq:NP_001119590.1|refseq:NP_001263626.1|refseq:NP_001263627.1|refseq:NP_001263628.1|refseq:NP_001263689.1|refseq:NP_001263690.1|dip:DIP-368N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2019/05/28 rogid:S8ihl3jxEEyMS46AM2ynXSFfCU49606 rogid:fGN3kSCGIpi/D6d/X5kaB0Xu8/k9606 intact-crc:FEA84E4597BF2CAC|rigid:5VpwlpQqzlunHNK7tN6q4Wo+lkI false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q09019 uniprotkb:O75694 intact:EBI-724564|ensembl:ENSP00000270223 intact:EBI-1050769|uniprotkb:Q9UBE9|uniprotkb:Q9UFL5|intact:EBI-28983292|ensembl:ENSP00000231498 psi-mi:dmwd_human(display_long)|uniprotkb:Dystrophia myotonica-containing WD repeat motif protein(gene name synonym)|uniprotkb:Protein DMR-N9(gene name synonym)|uniprotkb:Protein 59(gene name synonym)|uniprotkb:DMWD(gene name)|psi-mi:DMWD(display_short)|uniprotkb:DM9(gene name synonym) psi-mi:nu155_human(display_long)|uniprotkb:Nucleoporin Nup155(gene name synonym)|uniprotkb:155 kDa nucleoporin(gene name synonym)|uniprotkb:KIAA0791(gene name synonym)|uniprotkb:NUP155(gene name)|psi-mi:NUP155(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515767|imex:IM-12079-100 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004934.1|ensembl:ENSG00000185800(gene)|ensembl:ENST00000270223(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0030425"(dendrite)|go:"GO:0043204"(perikaryon)|interpro:IPR001680(WD40 repeat)|interpro:IPR036322|mint:Q09019 refseq:NP_004289.1|refseq:NP_705618.1|ensembl:ENSP00000231498|ensembl:ENST00000381843|ensembl:ENSP00000371265|ensembl:ENSG00000113569(gene)|ensembl:ENST00000231498(transcript)|go:"GO:0000972"(transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005829"(cytosol)|go:"GO:0006405"(RNA export from nucleus)|go:"GO:0006406"(mRNA export from nucleus)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006998"(nuclear envelope organization)|go:"GO:0016020"(membrane)|go:"GO:0017056"(structural constituent of nuclear pore)|go:"GO:0031965"(nuclear membrane)|go:"GO:0036228"(protein localization to nuclear inner membrane)|go:"GO:0044611"(nuclear pore inner ring)|go:"GO:0086014"(atrial cardiac muscle cell action potential)|interpro:IPR004870(Nucleoporin, non-repetitive/WGA-negative)|interpro:IPR007187(Nucleoporin, Nup133-like, C-terminal)|interpro:IPR014908(Nup133, N-terminal)|interpro:IPR042533|interpro:IPR042537|interpro:IPR042538|rcsb pdb:5A9Q|rcsb pdb:5IJN|rcsb pdb:5IJO|reactome:R-HSA-1169408|reactome:R-HSA-159227|reactome:R-HSA-159230|reactome:R-HSA-159231|reactome:R-HSA-159236|reactome:R-HSA-165054|reactome:R-HSA-168271|reactome:R-HSA-168276|reactome:R-HSA-168325|reactome:R-HSA-168333|reactome:R-HSA-170822|reactome:R-HSA-180746|reactome:R-HSA-180910|reactome:R-HSA-191859|reactome:R-HSA-3108214|reactome:R-HSA-3232142|reactome:R-HSA-3301854|reactome:R-HSA-3371453|reactome:R-HSA-4085377|reactome:R-HSA-4551638|reactome:R-HSA-4570464|reactome:R-HSA-4615885|reactome:R-HSA-5578749|reactome:R-HSA-5619107|reactome:R-HSA-6784531|reactome:R-HSA-9609690|reactome:R-HSA-9610379|reactome:R-HSA-9615933 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:76SLwlB1ohLxjwUwpPOR6gT4DP89606 rogid:k6LjWvJdqtT78G4Wu12rJX/2WHo9606 intact-crc:6EEED496ABE106E9|rigid:7x4rJPiAytQVc5YAOqF/Q8i5j90 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q09019 uniprotkb:Q16718 intact:EBI-724564|ensembl:ENSP00000270223 intact:EBI-746417|uniprotkb:Q6IRX7|uniprotkb:Q5H9R2|uniprotkb:B2RD98|ensembl:ENSP00000347988 psi-mi:dmwd_human(display_long)|uniprotkb:Dystrophia myotonica-containing WD repeat motif protein(gene name synonym)|uniprotkb:Protein DMR-N9(gene name synonym)|uniprotkb:Protein 59(gene name synonym)|uniprotkb:DMWD(gene name)|psi-mi:DMWD(display_short)|uniprotkb:DM9(gene name synonym) psi-mi:ndua5_human(display_long)|uniprotkb:Complex I subunit B13(gene name synonym)|uniprotkb:NADH-ubiquinone oxidoreductase 13 kDa-B subunit(gene name synonym)|uniprotkb:Complex I-13kD-B(gene name synonym)|uniprotkb:NDUFA5(gene name)|psi-mi:NDUFA5(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515767|imex:IM-12079-100 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004934.1|ensembl:ENSG00000185800(gene)|ensembl:ENST00000270223(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0030425"(dendrite)|go:"GO:0043204"(perikaryon)|interpro:IPR001680(WD40 repeat)|interpro:IPR036322|mint:Q09019 refseq:NP_004991.1|refseq:NP_001269348.1|refseq:NP_001269350.1|refseq:NP_001269351.1|ensembl:ENSG00000128609(gene)|ensembl:ENST00000355749(transcript)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0022904"(respiratory electron transport chain)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|interpro:IPR006806(ETC complex I subunit)|mint:Q16718|rcsb pdb:5XTB|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198|reactome:R-HSA-9013408|refseq:NP_001269349.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:76SLwlB1ohLxjwUwpPOR6gT4DP89606 rogid:t042+V0dLA6z/X1MQdgkt7ya7qs9606 intact-crc:6EEED496ABE106E9|rigid:7x4rJPiAytQVc5YAOqF/Q8i5j90 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q09019 uniprotkb:P51570 intact:EBI-724564|ensembl:ENSP00000270223 intact:EBI-2269932|uniprotkb:B2RC07|intact:EBI-6190170|uniprotkb:B4E1G6|ensembl:ENSP00000225614|ensembl:ENSP00000465930 psi-mi:dmwd_human(display_long)|uniprotkb:Dystrophia myotonica-containing WD repeat motif protein(gene name synonym)|uniprotkb:Protein DMR-N9(gene name synonym)|uniprotkb:Protein 59(gene name synonym)|uniprotkb:DMWD(gene name)|psi-mi:DMWD(display_short)|uniprotkb:DM9(gene name synonym) psi-mi:galk1_human(display_long)|uniprotkb:GALK1(gene name)|psi-mi:GALK1(display_short)|uniprotkb:GALK(gene name synonym)|uniprotkb:Galactose kinase(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515767|imex:IM-12079-100 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004934.1|ensembl:ENSG00000185800(gene)|ensembl:ENST00000270223(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0030425"(dendrite)|go:"GO:0043204"(perikaryon)|interpro:IPR001680(WD40 repeat)|interpro:IPR036322|mint:Q09019 go:"GO:0019388"(galactose catabolic process)|go:"GO:0019402"(galactitol metabolic process)|go:"GO:0061623"(glycolytic process from galactose)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000705(Galactokinase)|interpro:IPR006203(GHMP kinase, ATP-binding, conserved site)|interpro:IPR006204(GHMP kinase)|interpro:IPR006206(Mevalonate and galactokinase)|interpro:IPR013750(GHMP kinase, C-terminal)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR019539|interpro:IPR019741|interpro:IPR020568|interpro:IPR036554|mint:P51570|ensembl:ENSG00000108479(gene)|ensembl:ENST00000225614(transcript)|ensembl:ENST00000588479(transcript)|go:"GO:0004335"(galactokinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005534"(galactose binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006012"(galactose metabolic process)|go:"GO:0016020"(membrane)|rcsb pdb:1WUU|rcsb pdb:1YH7|rcsb pdb:6GR2|rcsb pdb:6Q3W|rcsb pdb:6Q3X|rcsb pdb:6Q8Z|rcsb pdb:6Q90|rcsb pdb:6Q91|rcsb pdb:6QJE|rcsb pdb:6ZFH|rcsb pdb:6ZGV|rcsb pdb:6ZGW|rcsb pdb:6ZGX|rcsb pdb:6ZGY|rcsb pdb:6ZGZ|reactome:R-HSA-5609976|reactome:R-HSA-70370 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:76SLwlB1ohLxjwUwpPOR6gT4DP89606 rogid:TtFcTQq+nspsst+xInA/huo/ZbU9606 intact-crc:6EEED496ABE106E9|rigid:7x4rJPiAytQVc5YAOqF/Q8i5j90 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q09019 uniprotkb:O60346 intact:EBI-724564|ensembl:ENSP00000270223 intact:EBI-2511516|intact:EBI-28974360|ensembl:ENSP00000262719|uniprotkb:Q6PJI6|uniprotkb:Q6P4C4|uniprotkb:A1A4F5|uniprotkb:Q641Q7|uniprotkb:Q86TN6|uniprotkb:Q96FK2|uniprotkb:Q9NUY1 psi-mi:dmwd_human(display_long)|uniprotkb:Dystrophia myotonica-containing WD repeat motif protein(gene name synonym)|uniprotkb:Protein DMR-N9(gene name synonym)|uniprotkb:Protein 59(gene name synonym)|uniprotkb:DMWD(gene name)|psi-mi:DMWD(display_short)|uniprotkb:DM9(gene name synonym) psi-mi:phlp1_human(display_long)|uniprotkb:PHLPP1(gene name)|psi-mi:PHLPP1(display_short)|uniprotkb:KIAA0606(gene name synonym)|uniprotkb:PHLPP(gene name synonym)|uniprotkb:PLEKHE1(gene name synonym)|uniprotkb:SCOP(gene name synonym)|uniprotkb:Pleckstrin homology domain-containing family E member 1(gene name synonym)|uniprotkb:Suprachiasmatic nucleus circadian oscillatory protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515767|imex:IM-12079-100 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004934.1|ensembl:ENSG00000185800(gene)|ensembl:ENST00000270223(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0030425"(dendrite)|go:"GO:0043204"(perikaryon)|interpro:IPR001680(WD40 repeat)|interpro:IPR036322|mint:Q09019 ensembl:ENSP00000262719|go:"GO:0009649"(entrainment of circadian clock)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046872"(metal ion binding)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1900744"(regulation of p38MAPK cascade)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001932(Protein phosphatase 2C-related)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR032675|interpro:IPR036457|mint:O60346|reactome:R-HSA-199418|ensembl:ENSG00000081913(gene)|ensembl:ENST00000262719(transcript)|go:"GO:0002667"(regulation of T cell anergy)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|refseq:NP_919431.2 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:76SLwlB1ohLxjwUwpPOR6gT4DP89606 rogid:hPGjeSVMlJhO3o9YBWoBm9xppfk9606 intact-crc:6EEED496ABE106E9|rigid:7x4rJPiAytQVc5YAOqF/Q8i5j90 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q09019 uniprotkb:P68871 intact:EBI-724564|ensembl:ENSP00000270223 intact:EBI-715554|ensembl:ENSP00000333994|ensembl:ENSP00000494175|uniprotkb:P02023|uniprotkb:Q13852|uniprotkb:Q14481|uniprotkb:Q14510|uniprotkb:Q45KT0|uniprotkb:Q6FI08|uniprotkb:Q8IZI1|uniprotkb:Q9BX96|uniprotkb:Q9UCP8|uniprotkb:Q9UCP9|uniprotkb:A4GX73|uniprotkb:B2ZUE0|uniprotkb:Q549N7|uniprotkb:Q6R7N2|uniprotkb:Q9UCD6 psi-mi:dmwd_human(display_long)|uniprotkb:Dystrophia myotonica-containing WD repeat motif protein(gene name synonym)|uniprotkb:Protein DMR-N9(gene name synonym)|uniprotkb:Protein 59(gene name synonym)|uniprotkb:DMWD(gene name)|psi-mi:DMWD(display_short)|uniprotkb:DM9(gene name synonym) psi-mi:hbb_human(display_long)|uniprotkb:Hemoglobin beta chain(gene name synonym)|uniprotkb:Beta-globin(gene name synonym)|uniprotkb:HBB(gene name)|psi-mi:HBB(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515767|imex:IM-12079-100 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004934.1|ensembl:ENSG00000185800(gene)|ensembl:ENST00000270223(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0030425"(dendrite)|go:"GO:0043204"(perikaryon)|interpro:IPR001680(WD40 repeat)|interpro:IPR036322|mint:Q09019 ensembl:ENSG00000244734(gene)|ensembl:ENST00000335295(transcript)|ensembl:ENST00000647020(transcript)|refseq:NP_000509.1|rcsb pdb:1XZ4|rcsb pdb:1XZ2|rcsb pdb:1XZ5|rcsb pdb:1XZ7|rcsb pdb:1XZU|rcsb pdb:1XZV|rcsb pdb:1Y09|rcsb pdb:1Y0A|rcsb pdb:1Y0C|rcsb pdb:1Y0D|rcsb pdb:1Y0T|rcsb pdb:1Y0W|rcsb pdb:1Y22|rcsb pdb:1Y2Z|rcsb pdb:1Y31|rcsb pdb:1Y35|rcsb pdb:1Y45|rcsb pdb:1Y46|rcsb pdb:1Y4B|rcsb pdb:1Y4F|rcsb pdb:1Y4G|rcsb pdb:1Y4P|rcsb pdb:1Y4Q|rcsb pdb:1Y4R|rcsb pdb:1Y4V|rcsb pdb:1Y5F|rcsb pdb:1Y5J|rcsb pdb:1Y5K|rcsb pdb:1Y7C|rcsb pdb:1Y7D|rcsb pdb:1Y7G|rcsb pdb:1Y7Z|rcsb pdb:1Y83|rcsb pdb:1Y85|rcsb pdb:1Y8W|rcsb pdb:1YDZ|rcsb pdb:1YE0|rcsb pdb:1YE1|rcsb pdb:1YE2|rcsb pdb:1YEN|rcsb pdb:1YEO|rcsb pdb:1YEQ|rcsb pdb:1YEU|rcsb pdb:1YEV|rcsb pdb:1YFF|rcsb pdb:1YG5|rcsb pdb:1YGD|rcsb pdb:1YGF|rcsb pdb:1YH9|rcsb pdb:1YHE|rcsb pdb:1YHR|rcsb pdb:1YIE|rcsb pdb:1YIH|rcsb pdb:1YVQ|rcsb pdb:1YZI|rcsb pdb:2D5Z|rcsb pdb:2D60|rcsb pdb:2DN1|rcsb pdb:2DN2|rcsb pdb:2DN3|rcsb pdb:2DXM|rcsb pdb:1YVT|rcsb pdb:2H35|rcsb pdb:2HBC|rcsb pdb:2HBD|rcsb pdb:2HBE|rcsb pdb:2HBF|rcsb pdb:2HBS|rcsb pdb:2HCO|rcsb pdb:2HHB|rcsb pdb:2HHD|rcsb pdb:2HHE|rcsb pdb:2M6Z|rcsb pdb:2W6V|rcsb pdb:2W72|rcsb pdb:2YRS|rcsb pdb:3B75|rcsb pdb:3D17|rcsb pdb:3D7O|rcsb pdb:3DUT|rcsb pdb:3HHB|rcsb pdb:3IC0|rcsb pdb:3IC2|rcsb pdb:3HXN|rcsb pdb:3KMF|rcsb pdb:3NL7|rcsb pdb:3NMM|rcsb pdb:3ODQ|rcsb pdb:3ONZ|rcsb pdb:3OO4|rcsb pdb:3OO5|rcsb pdb:3P5Q|rcsb pdb:3QJB|rcsb pdb:3QJC|rcsb pdb:3QJD|rcsb pdb:3QJE|rcsb pdb:3R5I|rcsb pdb:3S65|rcsb pdb:3S66|rcsb pdb:3SZK|go:"GO:0005344"(oxygen carrier activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005829"(cytosol)|go:"GO:0005833"(hemoglobin complex)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0015671"(oxygen transport)|go:"GO:0019825"(oxygen binding)|go:"GO:0020037"(heme binding)|go:"GO:0030185"(nitric oxide transport)|go:"GO:0030492"(hemoglobin binding)|go:"GO:0031721"(hemoglobin alpha binding)|go:"GO:0031838"(haptoglobin-hemoglobin complex)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042744"(hydrogen peroxide catabolic process)|go:"GO:0043177"(organic acid binding)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070293"(renal absorption)|go:"GO:0070527"(platelet aggregation)|go:"GO:0071682"(endocytic vesicle lumen)|go:"GO:0098869"(cellular oxidant detoxification)|go:"GO:1904724"(tertiary granule lumen)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000971(Globin, subset)|interpro:IPR002337(Haemoglobin, beta)|interpro:IPR009050(Globin-like)|interpro:IPR012292(Globin)|mint:P68871|rcsb pdb:1A00|rcsb pdb:1A01|rcsb pdb:1A0U|rcsb pdb:1A0Z|rcsb pdb:1A3N|go:"GO:0072562"(blood microparticle)|rcsb pdb:1A3O|rcsb pdb:1ABW|rcsb pdb:1ABY|rcsb pdb:1AJ9|rcsb pdb:1B86|rcsb pdb:1BAB|rcsb pdb:1BBB|rcsb pdb:1BIJ|rcsb pdb:1BUW|rcsb pdb:1BZ0|rcsb pdb:1BZ1|rcsb pdb:1BZZ|rcsb pdb:1C7B|rcsb pdb:1C7C|rcsb pdb:1C7D|rcsb pdb:1CBL|rcsb pdb:1CBM|rcsb pdb:1CH4|rcsb pdb:1CLS|rcsb pdb:1CMY|rcsb pdb:1COH|rcsb pdb:1DKE|rcsb pdb:1DXT|rcsb pdb:1DXU|rcsb pdb:1DXV|rcsb pdb:1FN3|rcsb pdb:1G9V|rcsb pdb:1GBU|rcsb pdb:1GBV|rcsb pdb:1GLI|rcsb pdb:1GZX|rcsb pdb:1HAB|rcsb pdb:1HAC|rcsb pdb:1HBA|rcsb pdb:1HBB|rcsb pdb:1HBS|rcsb pdb:1HCO|rcsb pdb:1HDB|rcsb pdb:1HGA|rcsb pdb:1HGB|rcsb pdb:1HGC|rcsb pdb:1HHO|rcsb pdb:1IRD|rcsb pdb:1J3Y|rcsb pdb:1J40|rcsb pdb:1J41|rcsb pdb:1J7S|rcsb pdb:1J7W|rcsb pdb:1J7Y|rcsb pdb:1JY7|rcsb pdb:1J3Z|rcsb pdb:1K0Y|rcsb pdb:1K1K|rcsb pdb:1KD2|rcsb pdb:1LFL|rcsb pdb:1LFQ|rcsb pdb:1LFT|rcsb pdb:1LFV|rcsb pdb:1LFY|rcsb pdb:1LFZ|rcsb pdb:1LJW|rcsb pdb:1M9P|rcsb pdb:1MKO|rcsb pdb:1NEJ|rcsb pdb:1NIH|rcsb pdb:1NQP|rcsb pdb:1O1I|rcsb pdb:1O1J|rcsb pdb:1O1K|rcsb pdb:1O1L|rcsb pdb:1O1M|rcsb pdb:1O1N|rcsb pdb:1O1O|rcsb pdb:1O1P|rcsb pdb:1QI8|rcsb pdb:1QSH|rcsb pdb:1QSI|rcsb pdb:1QXD|rcsb pdb:1QXE|rcsb pdb:1R1X|rcsb pdb:1R1Y|rcsb pdb:1RPS|rcsb pdb:1RQ3|rcsb pdb:1RQ4|rcsb pdb:1RQA|rcsb pdb:1RVW|rcsb pdb:1SDK|rcsb pdb:1SDL|rcsb pdb:1THB|rcsb pdb:1UIW|rcsb pdb:1VWT|rcsb pdb:1XXT|rcsb pdb:1XY0|rcsb pdb:1XYE|reactome:R-HSA-1237044|reactome:R-HSA-1247673|reactome:R-HSA-2168880|reactome:R-HSA-6798695|reactome:R-HSA-9613829|reactome:R-HSA-9615710|reactome:R-HSA-9707564|reactome:R-HSA-9707616|reactome:R-HSA-983231|rcsb pdb:7JY3|rcsb pdb:3WCP|rcsb pdb:3WHM|rcsb pdb:4FC3|rcsb pdb:4HHB|rcsb pdb:4IJ2|rcsb pdb:4L7Y|rcsb pdb:4M4A|rcsb pdb:4M4B|rcsb pdb:4MQC|rcsb pdb:4MQG|rcsb pdb:4MQH|rcsb pdb:4MQI|rcsb pdb:4N7N|rcsb pdb:4N7O|rcsb pdb:4N7P|rcsb pdb:4N8T|rcsb pdb:4NI0|rcsb pdb:3W4U|rcsb pdb:4NI1|rcsb pdb:4ROL|rcsb pdb:4WJG|rcsb pdb:4X0L|rcsb pdb:4XS0|rcsb pdb:5E29|rcsb pdb:5E6E|rcsb pdb:5E83|rcsb pdb:5EE4|rcsb pdb:5HU6|rcsb pdb:5HY8|rcsb pdb:5JDO|rcsb pdb:5KDQ|rcsb pdb:5KSI|rcsb pdb:5KSJ|rcsb pdb:5NI1|rcsb pdb:5SW7|rcsb pdb:5U3I|rcsb pdb:5UCU|rcsb pdb:5UFJ|rcsb pdb:5URC|rcsb pdb:5VMM|rcsb pdb:5WOG|rcsb pdb:5WOH|rcsb pdb:5X2R|rcsb pdb:5X2S|rcsb pdb:5X2T|rcsb pdb:5X2U|rcsb pdb:6BB5|rcsb pdb:6BNR|rcsb pdb:6BWP|rcsb pdb:6BWU|rcsb pdb:6DI4|rcsb pdb:6FQF|rcsb pdb:6HAL|rcsb pdb:4ROM|rcsb pdb:6HBW|rcsb pdb:6HK2|rcsb pdb:6KA9|rcsb pdb:6KAE|rcsb pdb:6KAH|rcsb pdb:6KAI|rcsb pdb:6KAO|rcsb pdb:6KAP|rcsb pdb:6KAQ|rcsb pdb:6KAR|rcsb pdb:6KAS|rcsb pdb:6KAT|rcsb pdb:6KAU|rcsb pdb:6KAV|rcsb pdb:6KYE|rcsb pdb:6L5V|rcsb pdb:6L5W|rcsb pdb:6L5X|rcsb pdb:6L5Y|rcsb pdb:6LCW|rcsb pdb:6LCX|rcsb pdb:6NBC|rcsb pdb:6NBD|rcsb pdb:6NQ5|rcsb pdb:6TB2|rcsb pdb:6XD9|rcsb pdb:6XDT|rcsb pdb:6XE7|rcsb pdb:7AET|rcsb pdb:7AEU|rcsb pdb:7AEV|rcsb pdb:7JJQ|rcsb pdb:7JXZ|rcsb pdb:7JY0|rcsb pdb:7JY1|dip:DIP-35526N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:76SLwlB1ohLxjwUwpPOR6gT4DP89606 rogid:Y5tl4dXE3PBfaK/0lROD6QJ4U+c9606 intact-crc:6EEED496ABE106E9|rigid:7x4rJPiAytQVc5YAOqF/Q8i5j90 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q09019 uniprotkb:P62068 intact:EBI-724564|ensembl:ENSP00000270223 intact:EBI-2512753|ensembl:ENSP00000407818|uniprotkb:B7Z675|uniprotkb:Q9H7U4|uniprotkb:B7Z7S3|uniprotkb:B7Z3Y7|uniprotkb:Q80V95|uniprotkb:Q9H9T8|uniprotkb:G8ACC7 psi-mi:dmwd_human(display_long)|uniprotkb:Dystrophia myotonica-containing WD repeat motif protein(gene name synonym)|uniprotkb:Protein DMR-N9(gene name synonym)|uniprotkb:Protein 59(gene name synonym)|uniprotkb:DMWD(gene name)|psi-mi:DMWD(display_short)|uniprotkb:DM9(gene name synonym) psi-mi:ubp46_human(display_long)|uniprotkb:USP46(gene name)|psi-mi:USP46(display_short)|uniprotkb:Ubiquitin-specific-processing protease 46(gene name synonym)|uniprotkb:Deubiquitinating enzyme 46(gene name synonym)|uniprotkb:Ubiquitin thioesterase 46(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515767|imex:IM-12079-100 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004934.1|ensembl:ENSG00000185800(gene)|ensembl:ENST00000270223(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0030425"(dendrite)|go:"GO:0043204"(perikaryon)|interpro:IPR001680(WD40 repeat)|interpro:IPR036322|mint:Q09019 ensembl:ENSG00000109189(gene)|ensembl:ENST00000441222(transcript)|go:"GO:0001662"(behavioral fear response)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008343"(adult feeding behavior)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0032228"(regulation of synaptic transmission, GABAergic)|go:"GO:0046872"(metal ion binding)|go:"GO:0048149"(behavioral response to ethanol)|go:"GO:0060013"(righting reflex)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|mint:P62068|rcsb pdb:5CVM|rcsb pdb:5CVN|rcsb pdb:5CVO|rcsb pdb:5L8H|rcsb pdb:6JLQ|refseq:NP_001273696.1|refseq:NP_001273697.1|refseq:NP_001127695.1|refseq:NP_073743.2|dip:DIP-53590N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:76SLwlB1ohLxjwUwpPOR6gT4DP89606 rogid:MYmLwHkGXhvq+vVvr88amlicCbg9606 intact-crc:6EEED496ABE106E9|rigid:7x4rJPiAytQVc5YAOqF/Q8i5j90 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q09019 uniprotkb:P19623 intact:EBI-724564|ensembl:ENSP00000270223 intact:EBI-1056183|uniprotkb:Q15511|uniprotkb:B1AKP9|ensembl:ENSP00000366156 psi-mi:dmwd_human(display_long)|uniprotkb:Dystrophia myotonica-containing WD repeat motif protein(gene name synonym)|uniprotkb:Protein DMR-N9(gene name synonym)|uniprotkb:Protein 59(gene name synonym)|uniprotkb:DMWD(gene name)|psi-mi:DMWD(display_short)|uniprotkb:DM9(gene name synonym) psi-mi:spee_human(display_long)|uniprotkb:SRM(gene name)|psi-mi:SRM(display_short)|uniprotkb:SPS1(gene name synonym)|uniprotkb:SRML1(gene name synonym)|uniprotkb:Putrescine aminopropyltransferase(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515767|imex:IM-12079-100 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004934.1|ensembl:ENSG00000185800(gene)|ensembl:ENST00000270223(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0030425"(dendrite)|go:"GO:0043204"(perikaryon)|interpro:IPR001680(WD40 repeat)|interpro:IPR036322|mint:Q09019 refseq:NP_003123.2|ensembl:ENSG00000116649(gene)|ensembl:ENST00000376957(transcript)|go:"GO:0004766"(spermidine synthase activity)|go:"GO:0005829"(cytosol)|go:"GO:0006595"(polyamine metabolic process)|go:"GO:0006596"(polyamine biosynthetic process)|go:"GO:0008295"(spermidine biosynthetic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR001045(Spermine synthase)|interpro:IPR029063|interpro:IPR030373|interpro:IPR030374|interpro:IPR030668|interpro:IPR035246|interpro:IPR037163|rcsb pdb:2O05|rcsb pdb:2O06|rcsb pdb:2O07|rcsb pdb:2O0L|rcsb pdb:3RW9|reactome:R-HSA-351202 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:76SLwlB1ohLxjwUwpPOR6gT4DP89606 rogid:VNjR3N2SwRzXIokl23Lis1pV3Pg9606 intact-crc:6EEED496ABE106E9|rigid:7x4rJPiAytQVc5YAOqF/Q8i5j90 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q09019 uniprotkb:P05109 intact:EBI-724564|ensembl:ENSP00000270223 intact:EBI-355281|uniprotkb:Q5SY70|uniprotkb:Q9UC92|uniprotkb:Q9UCJ0|uniprotkb:A8K5L3|uniprotkb:Q9UC84|uniprotkb:Q9UCM6|uniprotkb:D3DV37|ensembl:ENSP00000357721|ensembl:ENSP00000357722 psi-mi:dmwd_human(display_long)|uniprotkb:Dystrophia myotonica-containing WD repeat motif protein(gene name synonym)|uniprotkb:Protein DMR-N9(gene name synonym)|uniprotkb:Protein 59(gene name synonym)|uniprotkb:DMWD(gene name)|psi-mi:DMWD(display_short)|uniprotkb:DM9(gene name synonym) psi-mi:s10a8_human(display_long)|uniprotkb:S100A8(gene name)|psi-mi:S100A8(display_short)|uniprotkb:CAGA(gene name synonym)|uniprotkb:MRP8(gene name synonym)|uniprotkb:CFAG(gene name synonym)|uniprotkb:S100 calcium-binding protein A8(gene name synonym)|uniprotkb:Calgranulin-A(gene name synonym)|uniprotkb:Migration inhibitory factor-related protein 8(gene name synonym)|uniprotkb:Cystic fibrosis antigen(gene name synonym)|uniprotkb:Leukocyte L1 complex light chain(gene name synonym)|uniprotkb:Calprotectin L1L subunit(gene name synonym)|uniprotkb:Urinary stone protein band A(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515767|imex:IM-12079-100 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004934.1|ensembl:ENSG00000185800(gene)|ensembl:ENST00000270223(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0030425"(dendrite)|go:"GO:0043204"(perikaryon)|interpro:IPR001680(WD40 repeat)|interpro:IPR036322|mint:Q09019 refseq:NP_001306126.1|refseq:NP_001306127.1|refseq:NP_001306130.1|refseq:NP_002955.2|go:"GO:0042060"(wound healing)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045087"(innate immune response)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045471"(response to ethanol)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0050544"(arachidonic acid binding)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050786"(RAGE receptor binding)|go:"GO:0050832"(defense response to fungus)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070488"(neutrophil aggregation)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR001751(S100/CaBP-9k-type, calcium binding)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR013787(S100/CaBP-9k-type, calcium binding, subdomain)|interpro:IPR018247|interpro:IPR028474|go:"GO:0035662"(Toll-like receptor 4 binding)|mint:P05109|rcsb pdb:1MR8|rcsb pdb:1XK4|rcsb pdb:4GGF|rcsb pdb:4XJK|rcsb pdb:5HLO|rcsb pdb:5HLV|rcsb pdb:5W1F|rcsb pdb:6DS2|reactome:R-HSA-1236974|reactome:R-HSA-166058|reactome:R-HSA-5602498|reactome:R-HSA-5603041|reactome:R-HSA-5668599|reactome:R-HSA-5686938|reactome:R-HSA-6798695|reactome:R-HSA-6799990|ensembl:ENST00000368732(transcript)|ensembl:ENST00000368733(transcript)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0002526"(acute inflammatory response)|ensembl:ENSG00000143546(gene)|go:"GO:0002544"(chronic inflammatory response)|go:"GO:0002793"(positive regulation of peptide secretion)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0008017"(microtubule binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010043"(response to zinc ion)|go:"GO:0014002"(astrocyte development)|go:"GO:0018119"(peptidyl-cysteine S-nitrosylation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0032119"(sequestering of zinc ion)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0035425"(autocrine signaling)|dip:DIP-1165N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:76SLwlB1ohLxjwUwpPOR6gT4DP89606 rogid:3Okfhj8fxclZ0Uo/Fa1Z89qC8Ec9606 intact-crc:6EEED496ABE106E9|rigid:7x4rJPiAytQVc5YAOqF/Q8i5j90 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q09019 uniprotkb:P21333 intact:EBI-724564|ensembl:ENSP00000270223 intact:EBI-350432|uniprotkb:Q8NF52|intact:EBI-1103234|ensembl:ENSP00000358866|uniprotkb:Q5HY53|uniprotkb:Q5HY55|uniprotkb:E9KL45 psi-mi:dmwd_human(display_long)|uniprotkb:Dystrophia myotonica-containing WD repeat motif protein(gene name synonym)|uniprotkb:Protein DMR-N9(gene name synonym)|uniprotkb:Protein 59(gene name synonym)|uniprotkb:DMWD(gene name)|psi-mi:DMWD(display_short)|uniprotkb:DM9(gene name synonym) psi-mi:flna_human(display_long)|uniprotkb:FLNA(gene name)|psi-mi:FLNA(display_short)|uniprotkb:FLN(gene name synonym)|uniprotkb:FLN1(gene name synonym)|uniprotkb:Alpha-filamin(gene name synonym)|uniprotkb:Filamin-1(gene name synonym)|uniprotkb:Endothelial actin-binding protein(gene name synonym)|uniprotkb:Actin-binding protein 280(gene name synonym)|uniprotkb:Non-muscle filamin(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515767|imex:IM-12079-100 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004934.1|ensembl:ENSG00000185800(gene)|ensembl:ENST00000270223(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0030425"(dendrite)|go:"GO:0043204"(perikaryon)|interpro:IPR001680(WD40 repeat)|interpro:IPR036322|mint:Q09019 go:"GO:0007195"(adenylate cyclase-inhibiting dopamine receptor signaling pathway)|go:"GO:1902396"(protein localization to bicellular tight junction)|refseq:NP_001104026.1|refseq:NP_001447.2|ensembl:ENSG00000196924(gene)|ensembl:ENST00000369850(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003723"(RNA binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048680"(positive regulation of axon regeneration)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051015"(actin filament binding)|go:"GO:0051020"(GTPase binding)|go:"GO:0051220"(cytoplasmic sequestering of protein)|go:"GO:0051764"(actin crosslink formation)|go:"GO:0060271"(cilium assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:0071526"(semaphorin-plexin signaling pathway)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090042"(tubulin deacetylation)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:0097368"(establishment of Sertoli cell barrier)|go:"GO:0097440"(apical dendrite)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1901381"(positive regulation of potassium ion transmembrane transport)|go:"GO:0046332"(SMAD binding)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016479"(negative regulation of transcription by RNA polymerase I)|go:"GO:0019900"(kinase binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0021943"(formation of radial glial scaffolds)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030018"(Z disc)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031523"(Myb complex)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031852"(mu-type opioid receptor binding)|go:"GO:0032233"(positive regulation of actin filament bundle assembly)|go:"GO:0032432"(actin filament bundle)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0034988"(Fc-gamma receptor I complex binding)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043113"(receptor clustering)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043204"(perikaryon)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044319"(wound healing, spreading of cells)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0045296"(cadherin binding)|reactome:R-HSA-114608|reactome:R-HSA-430116|reactome:R-HSA-446353|reactome:R-HSA-5627123|reactome:R-HSA-8983711|rcsb pdb:6EW1|go:"GO:1905031"(regulation of membrane repolarization during cardiac muscle cell action potential)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2001046"(positive regulation of integrin-mediated signaling pathway)|go:"GO:2001224"(positive regulation of neuron migration)|interpro:IPR001298(Filamin/ABP280 repeat)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017868|interpro:IPR036872|interpro:IPR044801|mint:P21333|rcsb pdb:2AAV|rcsb pdb:2BP3|rcsb pdb:2BRQ|rcsb pdb:2J3S|rcsb pdb:2JF1|rcsb pdb:2K3T|rcsb pdb:2K7P|rcsb pdb:2K7Q|rcsb pdb:2MTP|rcsb pdb:2W0P|rcsb pdb:2WFN|rcsb pdb:3CNK|rcsb pdb:3HOC|rcsb pdb:3HOP|rcsb pdb:3HOR|rcsb pdb:3ISW|rcsb pdb:3RGH|rcsb pdb:4M9P|rcsb pdb:4P3W|rcsb pdb:5XR1|rcsb pdb:6D8C|go:"GO:1905000"(regulation of membrane repolarization during atrial cardiac muscle cell action potential)|dip:DIP-1136N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:76SLwlB1ohLxjwUwpPOR6gT4DP89606 rogid:ZxGK5OSMy8cNsyt7Ax2KXb8bn9M9606 intact-crc:6EEED496ABE106E9|rigid:7x4rJPiAytQVc5YAOqF/Q8i5j90 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q09019 uniprotkb:P04792 intact:EBI-724564|ensembl:ENSP00000270223 intact:EBI-352682|uniprotkb:Q6FI47|uniprotkb:Q96C20|uniprotkb:Q96EI7|uniprotkb:Q9UC34|uniprotkb:Q9UC35|uniprotkb:Q9UC36|uniprotkb:Q9UC31|ensembl:ENSP00000248553|uniprotkb:B2R4N8 psi-mi:dmwd_human(display_long)|uniprotkb:Dystrophia myotonica-containing WD repeat motif protein(gene name synonym)|uniprotkb:Protein DMR-N9(gene name synonym)|uniprotkb:Protein 59(gene name synonym)|uniprotkb:DMWD(gene name)|psi-mi:DMWD(display_short)|uniprotkb:DM9(gene name synonym) psi-mi:hspb1_human(display_long)|uniprotkb:HSPB1(gene name)|psi-mi:HSPB1(display_short)|uniprotkb:HSP27(gene name synonym)|uniprotkb:HSP28(gene name synonym)|uniprotkb:Heat shock 27 kDa protein(gene name synonym)|uniprotkb:Stress-responsive protein 27(gene name synonym)|uniprotkb:Estrogen-regulated 24 kDa protein(gene name synonym)|uniprotkb:28 kDa heat shock protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515767|imex:IM-12079-100 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004934.1|ensembl:ENSG00000185800(gene)|ensembl:ENST00000270223(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0030425"(dendrite)|go:"GO:0043204"(perikaryon)|interpro:IPR001680(WD40 repeat)|interpro:IPR036322|mint:Q09019 refseq:NP_001531.1|ensembl:ENSG00000106211(gene)|ensembl:ENST00000248553(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0001895"(retina homeostasis)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0003723"(RNA binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0008426"(protein kinase C inhibitor activity)|go:"GO:0009615"(response to virus)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030018"(Z disc)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0038033"(positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070527"(platelet aggregation)|go:"GO:0099641"(anterograde axonal protein transport)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1904115"(axon cytoplasm)|go:"GO:2001028"(positive regulation of endothelial cell chemotaxis)|interpro:IPR001436(Alpha crystallin/Heat shock protein)|interpro:IPR002068(Heat shock protein Hsp20)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR037876|mint:P04792|rcsb pdb:2N3J|rcsb pdb:3Q9P|rcsb pdb:3Q9Q|rcsb pdb:4MJH|rcsb pdb:6DV5|rcsb pdb:6GJH|reactome:R-HSA-4420097|reactome:R-HSA-450408|reactome:R-HSA-5687128|reactome:R-HSA-9009391|dip:DIP-412N psi-mi:"MI:0469"(intact) - crc64:1B4DC44A6F6606D5 figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:76SLwlB1ohLxjwUwpPOR6gT4DP89606 rogid:vrDXIdzP30aHSDLHOh2D4x54eJY9606 intact-crc:6EEED496ABE106E9|rigid:7x4rJPiAytQVc5YAOqF/Q8i5j90 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q09019 uniprotkb:Q8IZ69 intact:EBI-724564|ensembl:ENSP00000270223 intact:EBI-2515774|uniprotkb:Q9H732|uniprotkb:Q32P57|uniprotkb:Q96ME6|uniprotkb:D3DX25|ensembl:ENSP00000252136|ensembl:ENSP00000385807 psi-mi:dmwd_human(display_long)|uniprotkb:Dystrophia myotonica-containing WD repeat motif protein(gene name synonym)|uniprotkb:Protein DMR-N9(gene name synonym)|uniprotkb:Protein 59(gene name synonym)|uniprotkb:DMWD(gene name)|psi-mi:DMWD(display_short)|uniprotkb:DM9(gene name synonym) psi-mi:trm2a_human(display_long)|uniprotkb:TRMT2A(gene name)|psi-mi:TRMT2A(display_short)|uniprotkb:HTF9C(gene name synonym)|uniprotkb:HpaII tiny fragments locus 9c protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515767|imex:IM-12079-100 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004934.1|ensembl:ENSG00000185800(gene)|ensembl:ENST00000270223(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0030425"(dendrite)|go:"GO:0043204"(perikaryon)|interpro:IPR001680(WD40 repeat)|interpro:IPR036322|mint:Q09019 refseq:NP_073564.3|refseq:NP_892029.2|refseq:NP_001244923.1|ensembl:ENSP00000252136|ensembl:ENSP00000385807|ensembl:ENST00000404751|ensembl:ENSP00000384968|ensembl:ENSG00000099899(gene)|ensembl:ENST00000252136(transcript)|ensembl:ENST00000403707(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0006396"(RNA processing)|go:"GO:0008173"(RNA methyltransferase activity)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR010280("(Uracil-5)-methyltransferase")|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR029063|interpro:IPR034262|interpro:IPR035979|mint:Q8IZ69 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:76SLwlB1ohLxjwUwpPOR6gT4DP89606 rogid:/G2YDfinTNhJ+mPHfHOwSsyHQxE9606 intact-crc:6EEED496ABE106E9|rigid:7x4rJPiAytQVc5YAOqF/Q8i5j90 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q09019 uniprotkb:Q7Z4W1 intact:EBI-724564|ensembl:ENSP00000270223 intact:EBI-1044712|uniprotkb:Q9BTZ3|uniprotkb:Q9UHY9|ensembl:ENSP00000303356 psi-mi:dmwd_human(display_long)|uniprotkb:Dystrophia myotonica-containing WD repeat motif protein(gene name synonym)|uniprotkb:Protein DMR-N9(gene name synonym)|uniprotkb:Protein 59(gene name synonym)|uniprotkb:DMWD(gene name)|psi-mi:DMWD(display_short)|uniprotkb:DM9(gene name synonym) psi-mi:dcxr_human(display_long)|uniprotkb:Carbonyl reductase II(gene name synonym)|uniprotkb:Sperm surface protein P34H(gene name synonym)|uniprotkb:Dicarbonyl/L-xylulose reductase(gene name synonym)|uniprotkb:Kidney dicarbonyl reductase(gene name synonym)|uniprotkb:DCXR(gene name)|psi-mi:DCXR(display_short)|uniprotkb:SDR20C1(gene name synonym)|uniprotkb:Short chain dehydrogenase/reductase family 20C member 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515767|imex:IM-12079-100 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004934.1|ensembl:ENSG00000185800(gene)|ensembl:ENST00000270223(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0030425"(dendrite)|go:"GO:0043204"(perikaryon)|interpro:IPR001680(WD40 repeat)|interpro:IPR036322|mint:Q09019 refseq:NP_001182147.1|refseq:NP_057370.1|ensembl:ENSG00000169738(gene)|ensembl:ENST00000306869(transcript)|go:"GO:0004090"("carbonyl reductase (NADPH) activity")|go:"GO:0005634"(nucleus)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0005903"(brush border)|go:"GO:0005997"(xylulose metabolic process)|go:"GO:0006739"(NADP metabolic process)|go:"GO:0016655"("oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor")|go:"GO:0042732"(D-xylose metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0044105"("L-xylulose reductase (NAD+) activity")|go:"GO:0050038"("L-xylulose reductase (NADP+) activity")|go:"GO:0070062"(extracellular exosome)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR002347(Glucose/ribitol dehydrogenase)|interpro:IPR020904|go:"GO:0006006"(glucose metabolic process)|rcsb pdb:1PR9|rcsb pdb:1WNT|rcsb pdb:3D3W|reactome:R-HSA-5661270|reactome:R-HSA-5662853|interpro:IPR036291 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:76SLwlB1ohLxjwUwpPOR6gT4DP89606 rogid:CaPvjcjdsGXrcl0YtNceGUeTjTk9606 intact-crc:6EEED496ABE106E9|rigid:7x4rJPiAytQVc5YAOqF/Q8i5j90 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q09019 uniprotkb:O15460 intact:EBI-724564|ensembl:ENSP00000270223 intact:EBI-348033|ensembl:ENSP00000166534|ensembl:ENSP00000368398|ensembl:ENSP00000384999|uniprotkb:Q8WWN0|uniprotkb:D3DQ85|uniprotkb:D3DQ86 psi-mi:dmwd_human(display_long)|uniprotkb:Dystrophia myotonica-containing WD repeat motif protein(gene name synonym)|uniprotkb:Protein DMR-N9(gene name synonym)|uniprotkb:Protein 59(gene name synonym)|uniprotkb:DMWD(gene name)|psi-mi:DMWD(display_short)|uniprotkb:DM9(gene name synonym) psi-mi:p4ha2_human(display_long)|uniprotkb:UNQ290/PRO330(orf name)|uniprotkb:P4HA2(gene name)|psi-mi:P4HA2(display_short)|uniprotkb:Procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515767|imex:IM-12079-100 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004934.1|ensembl:ENSG00000185800(gene)|ensembl:ENST00000270223(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0030425"(dendrite)|go:"GO:0043204"(perikaryon)|interpro:IPR001680(WD40 repeat)|interpro:IPR036322|mint:Q09019 ensembl:ENST00000166534(transcript)|ensembl:ENST00000379104(transcript)|ensembl:ENST00000401867(transcript)|go:"GO:0004656"(procollagen-proline 4-dioxygenase activity)|go:"GO:0005506"(iron ion binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005829"(cytosol)|go:"GO:0009055"(electron transfer activity)|go:"GO:0018401"(peptidyl-proline hydroxylation to 4-hydroxy-L-proline)|go:"GO:0031418"(L-ascorbic acid binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR005123("2OG-Fe(II) oxygenase")|interpro:IPR006620(Prolyl 4-hydroxylase, alpha subunit)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013547(Prolyl 4-hydroxylase alpha-subunit, N-terminal)|interpro:IPR019734|mint:O15460|rcsb pdb:6EVL|rcsb pdb:6EVM|rcsb pdb:6EVN|rcsb pdb:6EVO|rcsb pdb:6EVP|reactome:R-HSA-1650814|ensembl:ENSG00000072682(gene)|refseq:NP_001136071.1|refseq:NP_004190.1|refseq:NP_001017973.1|refseq:NP_001017974.1|refseq:NP_001136070.1|refseq:XP_016865500.1|refseq:XP_005272173.1|refseq:XP_005272174.1|refseq:XP_005272175.1|refseq:XP_005272176.1|refseq:XP_005272177.1|refseq:XP_006714791.1|refseq:XP_006714792.1|refseq:XP_006714793.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:76SLwlB1ohLxjwUwpPOR6gT4DP89606 rogid:VppOE5KSA6wKWCFN4mCUJsFHDIA9606 intact-crc:6EEED496ABE106E9|rigid:7x4rJPiAytQVc5YAOqF/Q8i5j90 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q09019 uniprotkb:Q14160 intact:EBI-724564|ensembl:ENSP00000270223 intact:EBI-357345|uniprotkb:Q6P496|uniprotkb:Q7Z5D1|uniprotkb:Q8WWV8|uniprotkb:Q96C69|uniprotkb:Q96GG1|ensembl:ENSP00000322938|ensembl:ENSP00000349486|ensembl:ENSP00000366756 psi-mi:dmwd_human(display_long)|uniprotkb:Dystrophia myotonica-containing WD repeat motif protein(gene name synonym)|uniprotkb:Protein DMR-N9(gene name synonym)|uniprotkb:Protein 59(gene name synonym)|uniprotkb:DMWD(gene name)|psi-mi:DMWD(display_short)|uniprotkb:DM9(gene name synonym) psi-mi:scrib_human(display_long)|uniprotkb:SCRIB(gene name)|psi-mi:SCRIB(display_short)|uniprotkb:CRIB1(gene name synonym)|uniprotkb:KIAA0147(gene name synonym)|uniprotkb:LAP4(gene name synonym)|uniprotkb:SCRB1(gene name synonym)|uniprotkb:VARTUL(gene name synonym)|uniprotkb:Protein LAP4(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515767|imex:IM-12079-100 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004934.1|ensembl:ENSG00000185800(gene)|ensembl:ENST00000270223(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0030425"(dendrite)|go:"GO:0043204"(perikaryon)|interpro:IPR001680(WD40 repeat)|interpro:IPR036322|mint:Q09019 refseq:NP_056171.3|refseq:NP_874365.3|dip:DIP-31259N|ensembl:ENSG00000180900(gene)|ensembl:ENST00000320476(transcript)|ensembl:ENST00000356994(transcript)|ensembl:ENST00000377533(transcript)|go:"GO:0001768"(establishment of T cell polarity)|go:"GO:0001772"(immunological synapse)|go:"GO:0001843"(neural tube closure)|go:"GO:0001921"(positive regulation of receptor recycling)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0008283"(cell population proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016080"(synaptic vesicle targeting)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016477"(cell migration)|go:"GO:0021747"(cochlear nucleus development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030054"(cell junction)|go:"GO:0030683"(mitigation of host immune response by virus)|go:"GO:0030859"(polarized epithelial cell differentiation)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0034750"(Scrib-APC-beta-catenin complex)|go:"GO:0035089"(establishment of apical/basal cell polarity)|go:"GO:0035748"(myelin sheath abaxonal region)|go:"GO:0036342"(post-anal tail morphogenesis)|go:"GO:0039563"(suppression by virus of host JAK-STAT cascade via inhibition of STAT1 activity)|go:"GO:0039564"(suppression by virus of host JAK-STAT cascade via inhibition of STAT2 activity)|go:"GO:0042060"(wound healing)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043113"(receptor clustering)|go:"GO:0043615"(astrocyte cell migration)|go:"GO:0044291"(cell-cell contact zone)|go:"GO:0045197"(establishment or maintenance of epithelial cell apical/basal polarity)|go:"GO:0045296"(cadherin binding)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0050918"(positive chemotaxis)|go:"GO:0060088"(auditory receptor cell stereocilium organization)|go:"GO:0060561"(apoptotic process involved in morphogenesis)|go:"GO:0060603"(mammary gland duct morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071896"(protein localization to adherens junction)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097120"(receptor localization to synapse)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098793"(presynapse)|go:"GO:0098887"(neurotransmitter receptor transport, endosome to postsynaptic membrane)|go:"GO:0098968"(neurotransmitter receptor transport postsynaptic membrane to endosome)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099147"(extrinsic component of postsynaptic density membrane)|go:"GO:0099149"(regulation of postsynaptic neurotransmitter receptor internalization)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR032675|interpro:IPR036034|mint:Q14160|rcsb pdb:1UJU|rcsb pdb:1WHA|rcsb pdb:1X5Q|rcsb pdb:2W4F|rcsb pdb:4WYT|rcsb pdb:4WYU|rcsb pdb:5VWC|rcsb pdb:5VWI|rcsb pdb:5VWK|rcsb pdb:6EEY|rcsb pdb:6ESP|rcsb pdb:6MS1|rcsb pdb:6MTU|rcsb pdb:6MTV|rcsb pdb:6MYE|rcsb pdb:6MYF|rcsb pdb:6XA6|rcsb pdb:6XA7|rcsb pdb:6XA8|rcsb pdb:7JO7|reactome:R-HSA-4608870|reactome:R-HSA-9013148|reactome:R-HSA-9013406|reactome:R-HSA-9013409|reactome:R-HSA-9696264|reactome:R-HSA-9696270 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:76SLwlB1ohLxjwUwpPOR6gT4DP89606 rogid:y4lIQ2NivmndHYd/JXSKvU2jv+w9606 intact-crc:6EEED496ABE106E9|rigid:7x4rJPiAytQVc5YAOqF/Q8i5j90 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q09019 uniprotkb:Q9UET6 intact:EBI-724564|ensembl:ENSP00000270223 intact:EBI-1055987|uniprotkb:O75670|uniprotkb:B2RCJ0|ensembl:ENSP00000326948 psi-mi:dmwd_human(display_long)|uniprotkb:Dystrophia myotonica-containing WD repeat motif protein(gene name synonym)|uniprotkb:Protein DMR-N9(gene name synonym)|uniprotkb:Protein 59(gene name synonym)|uniprotkb:DMWD(gene name)|psi-mi:DMWD(display_short)|uniprotkb:DM9(gene name synonym) psi-mi:trm7_human(display_long)|uniprotkb:FTSJ1(gene name)|psi-mi:FTSJ1(display_short)|uniprotkb:JM23(orf name)|uniprotkb:Protein ftsJ homolog 1(gene name synonym)|uniprotkb:2'-O-ribose RNA methyltransferase TRM7 homolog(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515767|imex:IM-12079-100 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004934.1|ensembl:ENSG00000185800(gene)|ensembl:ENST00000270223(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0030425"(dendrite)|go:"GO:0043204"(perikaryon)|interpro:IPR001680(WD40 repeat)|interpro:IPR036322|mint:Q09019 refseq:NP_036412.1|refseq:NP_803188.1|refseq:NP_001269086.1|refseq:XP_005272652.1|ensembl:ENST00000348411(transcript)|go:"GO:0001510"(RNA methylation)|go:"GO:0002128"(tRNA nucleoside ribose methylation)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006400"(tRNA modification)|go:"GO:0008173"(RNA methyltransferase activity)|go:"GO:0008175"(tRNA methyltransferase activity)|go:"GO:0009020"("tRNA (guanosine-2'-O-)-methyltransferase activity")|go:"GO:0030488"(tRNA methylation)|go:"GO:0052666"("tRNA (cytosine-2'-O-)-methyltransferase activity")|interpro:IPR002877(Ribosomal RNA methyltransferase RrmJ/FtsJ)|interpro:IPR015507(Ribosomal RNA methyltransferase J)|interpro:IPR028590|interpro:IPR029063|mint:Q9UET6|reactome:R-HSA-6782315|ensembl:ENSG00000068438(gene) psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:76SLwlB1ohLxjwUwpPOR6gT4DP89606 rogid:N4L9nsU0Wj3FMVjYALdxpx56aZs9606 intact-crc:6EEED496ABE106E9|rigid:7x4rJPiAytQVc5YAOqF/Q8i5j90 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q09019 uniprotkb:Q16543 intact:EBI-724564|ensembl:ENSP00000270223 intact:EBI-295634|uniprotkb:Q53YA2|ensembl:ENSP00000222005 psi-mi:dmwd_human(display_long)|uniprotkb:Dystrophia myotonica-containing WD repeat motif protein(gene name synonym)|uniprotkb:Protein DMR-N9(gene name synonym)|uniprotkb:Protein 59(gene name synonym)|uniprotkb:DMWD(gene name)|psi-mi:DMWD(display_short)|uniprotkb:DM9(gene name synonym) psi-mi:cdc37_human(display_long)|uniprotkb:CDC37(gene name)|psi-mi:CDC37(display_short)|uniprotkb:Hsp90 chaperone protein kinase-targeting subunit(gene name synonym)|uniprotkb:p50Cdc37(gene name synonym)|uniprotkb:CDC37A(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515767|imex:IM-12079-100 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004934.1|ensembl:ENSG00000185800(gene)|ensembl:ENST00000270223(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0030425"(dendrite)|go:"GO:0043204"(perikaryon)|interpro:IPR001680(WD40 repeat)|interpro:IPR036322|mint:Q09019 refseq:NP_008996.1|dip:DIP-27560N|ensembl:ENSG00000105401(gene)|ensembl:ENST00000222005(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0006605"(protein targeting)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0060334"(regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0060338"(regulation of type I interferon-mediated signaling pathway)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0101031"(chaperone complex)|go:"GO:1990565"(HSP90-CDC37 chaperone complex)|interpro:IPR004918(Cdc37)|interpro:IPR013855(Cdc37, N-terminal)|interpro:IPR013873(Cdc37, C-terminal)|interpro:IPR013874(Cdc37, Hsp90 binding)|interpro:IPR038189|mint:Q16543|rcsb pdb:1US7|rcsb pdb:2K5B|rcsb pdb:2N5X|rcsb pdb:2NCA|rcsb pdb:2W0G|rcsb pdb:5FWK|rcsb pdb:5FWL|rcsb pdb:5FWM|rcsb pdb:5FWP|rcsb pdb:5HPE|reactome:R-HSA-1227986|reactome:R-HSA-1236382|reactome:R-HSA-5637810|reactome:R-HSA-5675482|reactome:R-HSA-8863795|reactome:R-HSA-9013418|reactome:R-HSA-9634285|reactome:R-HSA-9652282|reactome:R-HSA-9664565|reactome:R-HSA-9665233|reactome:R-HSA-9665244|reactome:R-HSA-9665245|reactome:R-HSA-9665246|reactome:R-HSA-9665247|reactome:R-HSA-9665249|reactome:R-HSA-9665250|reactome:R-HSA-9665251|reactome:R-HSA-9665348|reactome:R-HSA-9665686|reactome:R-HSA-9665737 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:76SLwlB1ohLxjwUwpPOR6gT4DP89606 rogid:iajhitd2iEmd17KfpU/nMaKc4049606 intact-crc:6EEED496ABE106E9|rigid:7x4rJPiAytQVc5YAOqF/Q8i5j90 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q09019 uniprotkb:P50213 intact:EBI-724564|ensembl:ENSP00000270223 intact:EBI-355999|uniprotkb:D3DW83|uniprotkb:Q9H3X0|ensembl:ENSP00000299518 psi-mi:dmwd_human(display_long)|uniprotkb:Dystrophia myotonica-containing WD repeat motif protein(gene name synonym)|uniprotkb:Protein DMR-N9(gene name synonym)|uniprotkb:Protein 59(gene name synonym)|uniprotkb:DMWD(gene name)|psi-mi:DMWD(display_short)|uniprotkb:DM9(gene name synonym) psi-mi:idh3a_human(display_long)|uniprotkb:IDH3A(gene name)|psi-mi:IDH3A(display_short)|uniprotkb:Isocitric dehydrogenase subunit alpha(gene name synonym)|uniprotkb:"NAD(+)-specific ICDH subunit alpha"(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515767|imex:IM-12079-100 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004934.1|ensembl:ENSG00000185800(gene)|ensembl:ENST00000270223(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0030425"(dendrite)|go:"GO:0043204"(perikaryon)|interpro:IPR001680(WD40 repeat)|interpro:IPR036322|mint:Q09019 refseq:NP_005521.1|interpro:IPR024084|ensembl:ENSG00000166411(gene)|ensembl:ENST00000299518(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004449"("isocitrate dehydrogenase (NAD+) activity")|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006102"(isocitrate metabolic process)|go:"GO:0051287"(NAD binding)|interpro:IPR004434(Isocitrate dehydrogenase NAD-dependent, mitochondrial)|interpro:IPR019818|mint:P50213|rcsb pdb:5GRE|rcsb pdb:5GRF|rcsb pdb:5GRH|rcsb pdb:5GRI|rcsb pdb:5GRL|rcsb pdb:5YVT|rcsb pdb:6KDE|rcsb pdb:6KDF|rcsb pdb:6KDY|rcsb pdb:6KE3|rcsb pdb:6L57|rcsb pdb:6L59|rcsb pdb:7CE3|reactome:R-HSA-71403 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:76SLwlB1ohLxjwUwpPOR6gT4DP89606 rogid:JvAUAMJ0DcgnIfvy/vlfRyXYzhE9606 intact-crc:6EEED496ABE106E9|rigid:7x4rJPiAytQVc5YAOqF/Q8i5j90 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q09019 uniprotkb:P08709 intact:EBI-724564|ensembl:ENSP00000270223 intact:EBI-355972|ensembl:ENSP00000364731|uniprotkb:Q14339|uniprotkb:Q5JVF2|uniprotkb:B0YJC8|uniprotkb:Q5JVF1|uniprotkb:Q9UD52|uniprotkb:Q9UD53|uniprotkb:Q9UD54 psi-mi:dmwd_human(display_long)|uniprotkb:Dystrophia myotonica-containing WD repeat motif protein(gene name synonym)|uniprotkb:Protein DMR-N9(gene name synonym)|uniprotkb:Protein 59(gene name synonym)|uniprotkb:DMWD(gene name)|psi-mi:DMWD(display_short)|uniprotkb:DM9(gene name synonym) psi-mi:fa7_human(display_long)|uniprotkb:F7(gene name)|psi-mi:F7(display_short)|uniprotkb:Serum prothrombin conversion accelerator(gene name synonym)|uniprotkb:Proconvertin(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515767|imex:IM-12079-100 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004934.1|ensembl:ENSG00000185800(gene)|ensembl:ENST00000270223(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0030425"(dendrite)|go:"GO:0043204"(perikaryon)|interpro:IPR001680(WD40 repeat)|interpro:IPR036322|mint:Q09019 ensembl:ENSG00000057593(gene)|ensembl:ENST00000375581(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002690"(positive regulation of leukocyte chemotaxis)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0007596"(blood coagulation)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0010037"(response to carbon dioxide)|go:"GO:0010641"(positive regulation of platelet-derived growth factor receptor signaling pathway)|go:"GO:0016485"(protein processing)|go:"GO:0030194"(positive regulation of blood coagulation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0031982"(vesicle)|go:"GO:0032355"(response to estradiol)|go:"GO:0032571"(response to vitamin K)|go:"GO:0033595"(response to genistein)|go:"GO:0043627"(response to estrogen)|rcsb pdb:1F7M|rcsb pdb:1FAK|rcsb pdb:1FF7|go:"GO:0050927"(positive regulation of positive chemotaxis)|rcsb pdb:1FFM|rcsb pdb:1J9C|rcsb pdb:1JBU|go:"GO:0051897"(positive regulation of protein kinase B signaling)|rcsb pdb:1KLI|go:"GO:0060416"(response to growth hormone)|go:"GO:0061476"(response to anticoagulant)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070723"(response to cholesterol)|go:"GO:0097068"(response to thyroxine)|go:"GO:1904400"(response to Thyroid stimulating hormone)|go:"GO:1904612"(response to 2,3,7,8-tetrachlorodibenzodioxine)|go:"GO:1905217"(response to astaxanthin)|go:"GO:1905225"(response to thyrotropin-releasing hormone)|go:"GO:1905286"(serine-type peptidase complex)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000294(Vitamin K-dependent carboxylation/gamma-carboxyglutamic region)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR012224(Peptidase S1A, coagulation factor VII/IX/X/C/Z)|interpro:IPR017857(Coagulation factor, subset, Gla region)|interpro:IPR018097|interpro:IPR018114|interpro:IPR033116|interpro:IPR033190|interpro:IPR035972|interpro:IPR043504|rcsb pdb:1BF9|rcsb pdb:1CVW|rcsb pdb:1DAN|rcsb pdb:1DVA|rcsb pdb:1F7E|rcsb pdb:1KLJ|rcsb pdb:1NL8|rcsb pdb:1O5D|rcsb pdb:1QFK|rcsb pdb:1W0Y|rcsb pdb:1W2K|rcsb pdb:1W7X|rcsb pdb:1W8B|rcsb pdb:1WQV|rcsb pdb:1WSS|rcsb pdb:1WTG|rcsb pdb:1WUN|rcsb pdb:1WV7|rcsb pdb:1YGC|rcsb pdb:1Z6J|rcsb pdb:2A2Q|rcsb pdb:2AEI|rcsb pdb:2AER|rcsb pdb:2B7D|rcsb pdb:2B8O|rcsb pdb:2BZ6|rcsb pdb:2C4F|rcsb pdb:2EC9|rcsb pdb:2F9B|rcsb pdb:2FIR|rcsb pdb:2FLB|rcsb pdb:2FLR|rcsb pdb:2PUQ|refseq:NP_000122.1|refseq:NP_062562.1|rcsb pdb:2ZP0|rcsb pdb:2ZWL|rcsb pdb:2ZZU|rcsb pdb:3ELA|rcsb pdb:3TH2|rcsb pdb:3TH3|rcsb pdb:3TH4|rcsb pdb:4IBL|rcsb pdb:4ISH|rcsb pdb:4ISI|rcsb pdb:4JYU|rcsb pdb:4JYV|rcsb pdb:4JZD|rcsb pdb:4JZE|rcsb pdb:4JZF|rcsb pdb:4NA9|rcsb pdb:4NG9|rcsb pdb:4NGA|rcsb pdb:4X8S|rcsb pdb:4X8T|rcsb pdb:4X8U|rcsb pdb:4X8V|rcsb pdb:4YLQ|rcsb pdb:4YT6|rcsb pdb:4YT7|rcsb pdb:4Z6A|rcsb pdb:4ZMA|rcsb pdb:4ZXX|rcsb pdb:4ZXY|rcsb pdb:5I46|rcsb pdb:5L0S|rcsb pdb:5L2Y|rcsb pdb:5L2Z|rcsb pdb:5L30|rcsb pdb:5PA8|rcsb pdb:5PA9|rcsb pdb:5PAA|rcsb pdb:5PAB|rcsb pdb:5PAC|rcsb pdb:5PAE|rcsb pdb:5PAF|rcsb pdb:5PAG|rcsb pdb:5PAI|rcsb pdb:5PAJ|rcsb pdb:5PAK|rcsb pdb:5PAM|rcsb pdb:5PAN|rcsb pdb:5PAO|rcsb pdb:5PAQ|rcsb pdb:5PAR|rcsb pdb:5PAS|rcsb pdb:5PAT|rcsb pdb:5PAU|rcsb pdb:5PAV|rcsb pdb:5PAW|rcsb pdb:5PAX|rcsb pdb:5PAY|rcsb pdb:5PB0|rcsb pdb:5PB1|rcsb pdb:5PB2|rcsb pdb:5PB3|rcsb pdb:5PB4|rcsb pdb:5PB5|rcsb pdb:5PB6|rcsb pdb:5TQE|rcsb pdb:5TQF|rcsb pdb:5TQG|rcsb pdb:5U6J|reactome:R-HSA-1368108|reactome:R-HSA-140834|reactome:R-HSA-159740|reactome:R-HSA-159763|reactome:R-HSA-159782|dip:DIP-6135N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:76SLwlB1ohLxjwUwpPOR6gT4DP89606 rogid:3AajTD0zonhwhwLyNtQ1rIKrgRI9606 intact-crc:6EEED496ABE106E9|rigid:7x4rJPiAytQVc5YAOqF/Q8i5j90 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q09019 uniprotkb:O60346 intact:EBI-724564|ensembl:ENSP00000270223 intact:EBI-2511516|intact:EBI-28974360|ensembl:ENSP00000262719|uniprotkb:Q6PJI6|uniprotkb:Q6P4C4|uniprotkb:A1A4F5|uniprotkb:Q641Q7|uniprotkb:Q86TN6|uniprotkb:Q96FK2|uniprotkb:Q9NUY1 psi-mi:dmwd_human(display_long)|uniprotkb:Dystrophia myotonica-containing WD repeat motif protein(gene name synonym)|uniprotkb:Protein DMR-N9(gene name synonym)|uniprotkb:Protein 59(gene name synonym)|uniprotkb:DMWD(gene name)|psi-mi:DMWD(display_short)|uniprotkb:DM9(gene name synonym) psi-mi:phlp1_human(display_long)|uniprotkb:PHLPP1(gene name)|psi-mi:PHLPP1(display_short)|uniprotkb:KIAA0606(gene name synonym)|uniprotkb:PHLPP(gene name synonym)|uniprotkb:PLEKHE1(gene name synonym)|uniprotkb:SCOP(gene name synonym)|uniprotkb:Pleckstrin homology domain-containing family E member 1(gene name synonym)|uniprotkb:Suprachiasmatic nucleus circadian oscillatory protein(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515767|imex:IM-12079-100 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004934.1|ensembl:ENSG00000185800(gene)|ensembl:ENST00000270223(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0030425"(dendrite)|go:"GO:0043204"(perikaryon)|interpro:IPR001680(WD40 repeat)|interpro:IPR036322|mint:Q09019 ensembl:ENSP00000262719|go:"GO:0009649"(entrainment of circadian clock)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046872"(metal ion binding)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1900744"(regulation of p38MAPK cascade)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001932(Protein phosphatase 2C-related)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR032675|interpro:IPR036457|mint:O60346|reactome:R-HSA-199418|ensembl:ENSG00000081913(gene)|ensembl:ENST00000262719(transcript)|go:"GO:0002667"(regulation of T cell anergy)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|refseq:NP_919431.2 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:76SLwlB1ohLxjwUwpPOR6gT4DP89606 rogid:hPGjeSVMlJhO3o9YBWoBm9xppfk9606 intact-crc:6EEED496ABE106E9|rigid:7x4rJPiAytQVc5YAOqF/Q8i5j90 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q09019 uniprotkb:P26640 intact:EBI-724564|ensembl:ENSP00000270223 intact:EBI-355765|uniprotkb:Q5JQ90|uniprotkb:Q96E77|uniprotkb:Q9UQM2|uniprotkb:B4DZ61|uniprotkb:B0V1N1|ensembl:ENSP00000211402|ensembl:ENSP00000364815|ensembl:ENSP00000401121|ensembl:ENSP00000403359|ensembl:ENSP00000415316 psi-mi:dmwd_human(display_long)|uniprotkb:Dystrophia myotonica-containing WD repeat motif protein(gene name synonym)|uniprotkb:Protein DMR-N9(gene name synonym)|uniprotkb:Protein 59(gene name synonym)|uniprotkb:DMWD(gene name)|psi-mi:DMWD(display_short)|uniprotkb:DM9(gene name synonym) psi-mi:syvc_human(display_long)|uniprotkb:VARS1(gene name)|psi-mi:VARS1(display_short)|uniprotkb:G7A(gene name synonym)|uniprotkb:Protein G7a(gene name synonym)|uniprotkb:VARS(gene name synonym)|uniprotkb:VARS2(gene name synonym)|uniprotkb:Valyl-tRNA synthetase(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515767|imex:IM-12079-100 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004934.1|ensembl:ENSG00000185800(gene)|ensembl:ENST00000270223(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0030425"(dendrite)|go:"GO:0043204"(perikaryon)|interpro:IPR001680(WD40 repeat)|interpro:IPR036322|mint:Q09019 refseq:NP_006286.1|ensembl:ENSG00000096171(gene)|ensembl:ENSG00000204394(gene)|ensembl:ENSG00000224264(gene)|ensembl:ENSG00000226589(gene)|ensembl:ENSG00000231116(gene)|ensembl:ENST00000211402(transcript)|ensembl:ENST00000375663(transcript)|ensembl:ENST00000422694(transcript)|ensembl:ENST00000435657(transcript)|ensembl:ENST00000457796(transcript)|go:"GO:0002161"(aminoacyl-tRNA editing activity)|go:"GO:0004832"(valine-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0006418"(tRNA aminoacylation for protein translation)|go:"GO:0006438"(valyl-tRNA aminoacylation)|interpro:IPR001412(Aminoacyl-tRNA synthetase, class I, conserved site)|interpro:IPR002300(Aminoacyl-tRNA synthetase, class Ia)|interpro:IPR002303(Valyl-tRNA synthetase, class Ia)|interpro:IPR004046(Glutathione S-transferase, C-terminal)|interpro:IPR009008(Valyl/Leucyl/Isoleucyl-tRNA synthetase, class Ia, editing)|interpro:IPR009080(Aminoacyl-tRNA synthetase, class 1a, anticodon-binding)|interpro:IPR010987(Glutathione S-transferase, C-terminal-like)|interpro:IPR013155(Valyl/Leucyl/Isoleucyl-tRNA synthetase, class I, anticodon-binding)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR033705|interpro:IPR036282|interpro:IPR037118|mint:P26640|reactome:R-HSA-379716 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:76SLwlB1ohLxjwUwpPOR6gT4DP89606 rogid:aPfpK0/C2KpCsMOI0sjCreufI509606 intact-crc:6EEED496ABE106E9|rigid:7x4rJPiAytQVc5YAOqF/Q8i5j90 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q09019 uniprotkb:P07858 intact:EBI-724564|ensembl:ENSP00000270223 intact:EBI-715062|uniprotkb:Q503A6|uniprotkb:Q96D87|uniprotkb:B3KRR5|uniprotkb:B3KQR5|ensembl:ENSP00000503300|ensembl:ENSP00000503435|ensembl:ENSP00000503487|ensembl:ENSP00000503513|ensembl:ENSP00000503578|ensembl:ENSP00000503608|ensembl:ENSP00000503652|ensembl:ENSP00000503674|ensembl:ENSP00000503858|ensembl:ENSP00000503909|ensembl:ENSP00000504161|ensembl:ENSP00000504226|ensembl:ENSP00000504336|ensembl:ENSP00000504480|ensembl:ENSP00000504638|ensembl:ENSP00000504659|ensembl:ENSP00000504797|ensembl:ENSP00000503280|ensembl:ENSP00000342070|ensembl:ENSP00000345672|ensembl:ENSP00000431143|ensembl:ENSP00000431518|ensembl:ENSP00000432077|ensembl:ENSP00000432244|ensembl:ENSP00000432408|ensembl:ENSP00000433215|ensembl:ENSP00000433379|ensembl:ENSP00000433929|ensembl:ENSP00000434217|ensembl:ENSP00000434725|ensembl:ENSP00000435074|ensembl:ENSP00000435105|ensembl:ENSP00000435260|ensembl:ENSP00000435886|ensembl:ENSP00000473301|ensembl:ENSP00000502963|ensembl:ENSP00000503006|ensembl:ENSP00000503052|ensembl:ENSP00000503078|ensembl:ENSP00000503174 psi-mi:dmwd_human(display_long)|uniprotkb:Dystrophia myotonica-containing WD repeat motif protein(gene name synonym)|uniprotkb:Protein DMR-N9(gene name synonym)|uniprotkb:Protein 59(gene name synonym)|uniprotkb:DMWD(gene name)|psi-mi:DMWD(display_short)|uniprotkb:DM9(gene name synonym) psi-mi:catb_human(display_long)|uniprotkb:Cathepsin B1(gene name synonym)|uniprotkb:APP secretase(gene name synonym)|uniprotkb:CTSB(gene name)|psi-mi:CTSB(display_short)|uniprotkb:CPSB(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515767|imex:IM-12079-100 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004934.1|ensembl:ENSG00000185800(gene)|ensembl:ENST00000270223(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0030425"(dendrite)|go:"GO:0043204"(perikaryon)|interpro:IPR001680(WD40 repeat)|interpro:IPR036322|mint:Q09019 refseq:NP_001899.1|refseq:NP_680090.1|refseq:NP_680091.1|refseq:NP_680092.1|refseq:NP_680093.1|refseq:XP_011542114.1|refseq:XP_016868586.1|refseq:XP_016868587.1|refseq:XP_016868588.1|refseq:XP_016868589.1|ensembl:ENST00000345125(transcript)|ensembl:ENST00000353047(transcript)|ensembl:ENST00000524654(transcript)|ensembl:ENST00000526481(transcript)|ensembl:ENST00000526645(transcript)|ensembl:ENST00000527215(transcript)|ensembl:ENST00000534382(transcript)|ensembl:ENST00000527243(transcript)|ensembl:ENST00000534510(transcript)|ensembl:ENST00000676691(transcript)|ensembl:ENST00000676755(transcript)|ensembl:ENST00000676825(transcript)|ensembl:ENST00000676843(transcript)|ensembl:ENST00000676952(transcript)|ensembl:ENST00000677082(transcript)|ensembl:ENST00000677366(transcript)|ensembl:ENST00000677415(transcript)|ensembl:ENST00000528965(transcript)|ensembl:ENST00000530296(transcript)|ensembl:ENST00000530640(transcript)|ensembl:ENST00000677418(transcript)|ensembl:ENST00000677544(transcript)|ensembl:ENST00000677650(transcript)|ensembl:ENST00000677671(transcript)|ensembl:ENST00000677819(transcript)|ensembl:ENST00000677873(transcript)|ensembl:ENST00000678092(transcript)|ensembl:ENST00000678145(transcript)|ensembl:ENST00000678242(transcript)|ensembl:ENST00000531089(transcript)|ensembl:ENST00000678357(transcript)|ensembl:ENST00000531502(transcript)|ensembl:ENST00000678615(transcript)|ensembl:ENST00000532392(transcript)|ensembl:ENST00000678929(transcript)|ensembl:ENST00000532656(transcript)|ensembl:ENST00000533455(transcript)|ensembl:ENST00000679051(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005622"(intracellular anatomical structure)|go:"GO:0005764"(lysosome)|go:"GO:0006508"(proteolysis)|go:"GO:0006590"(thyroid hormone generation)|go:"GO:0008233"(peptidase activity)|go:"GO:0008234"(cysteine-type peptidase activity)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030574"(collagen catabolic process)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0036021"(endolysosome lumen)|go:"GO:0042470"(melanosome)|go:"GO:0042981"(regulation of apoptotic process)|ensembl:ENST00000679128(transcript)|go:"GO:0043394"(proteoglycan binding)|ensembl:ENST00000679140(transcript)|go:"GO:0046697"(decidualization)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0005518"(collagen binding)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0097067"(cellular response to thyroid hormone stimulus)|ensembl:ENSG00000164733(gene)|interpro:IPR000169(Peptidase, cysteine peptidase active site)|interpro:IPR000668(Peptidase C1A, papain C-terminal)|interpro:IPR012599(Peptidase C1A, propeptide)|interpro:IPR025660|interpro:IPR025661|interpro:IPR038765|mint:P07858|rcsb pdb:1CSB|rcsb pdb:1GMY|rcsb pdb:1HUC|rcsb pdb:1PBH|rcsb pdb:2IPP|rcsb pdb:2PBH|rcsb pdb:3AI8|rcsb pdb:3CBJ|rcsb pdb:3CBK|rcsb pdb:3K9M|rcsb pdb:3PBH|rcsb pdb:5MBL|rcsb pdb:5MBM|rcsb pdb:6AY2|reactome:R-HSA-1442490|reactome:R-HSA-1679131|reactome:R-HSA-2022090|reactome:R-HSA-2132295|reactome:R-HSA-6798695|go:"GO:1904813"(ficolin-1-rich granule lumen)|refseq:XP_006716307.1|refseq:XP_006716308.1|dip:DIP-42785N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:76SLwlB1ohLxjwUwpPOR6gT4DP89606 rogid:TdxD7Gf4BmlJcfUSULihf9W3sKQ9606 intact-crc:6EEED496ABE106E9|rigid:7x4rJPiAytQVc5YAOqF/Q8i5j90 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q09019 uniprotkb:P55786 intact:EBI-724564|ensembl:ENSP00000270223 intact:EBI-1046129|uniprotkb:Q6P145|uniprotkb:Q9NP16|uniprotkb:Q9UEM2|ensembl:ENSP00000320324|ensembl:ENSP00000503682|uniprotkb:B7Z463 psi-mi:dmwd_human(display_long)|uniprotkb:Dystrophia myotonica-containing WD repeat motif protein(gene name synonym)|uniprotkb:Protein DMR-N9(gene name synonym)|uniprotkb:Protein 59(gene name synonym)|uniprotkb:DMWD(gene name)|psi-mi:DMWD(display_short)|uniprotkb:DM9(gene name synonym) psi-mi:psa_human(display_long)|uniprotkb:NPEPPS(gene name)|psi-mi:NPEPPS(display_short)|uniprotkb:PSA(gene name synonym)|uniprotkb:Cytosol alanyl aminopeptidase(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515767|imex:IM-12079-100 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004934.1|ensembl:ENSG00000185800(gene)|ensembl:ENST00000270223(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0030425"(dendrite)|go:"GO:0043204"(perikaryon)|interpro:IPR001680(WD40 repeat)|interpro:IPR036322|mint:Q09019 refseq:NP_006301.3|ensembl:ENSG00000141279(gene)|ensembl:ENST00000322157(transcript)|ensembl:ENST00000677120(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004177"(aminopeptidase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006508"(proteolysis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0042277"(peptide binding)|go:"GO:0043171"(peptide catabolic process)|go:"GO:0070006"(metalloaminopeptidase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|interpro:IPR001930(Peptidase M1, membrane alanine aminopeptidase)|interpro:IPR014782(Peptidase M1, membrane alanine aminopeptidase, N-terminal)|interpro:IPR024571|interpro:IPR027268|interpro:IPR034016|interpro:IPR042097|reactome:R-HSA-983168|refseq:NP_001317186.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:76SLwlB1ohLxjwUwpPOR6gT4DP89606 rogid:gDl9SPlJhCOhA8uF4OEw+lIPh2M9606 intact-crc:6EEED496ABE106E9|rigid:7x4rJPiAytQVc5YAOqF/Q8i5j90 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q09019 uniprotkb:Q96I99 intact:EBI-724564|ensembl:ENSP00000270223 intact:EBI-2511878|ensembl:ENSP00000307432|uniprotkb:Q8WUQ1|uniprotkb:Q86VX8|uniprotkb:O95195|uniprotkb:Q6NUH7|uniprotkb:C9JVT2 psi-mi:dmwd_human(display_long)|uniprotkb:Dystrophia myotonica-containing WD repeat motif protein(gene name synonym)|uniprotkb:Protein DMR-N9(gene name synonym)|uniprotkb:Protein 59(gene name synonym)|uniprotkb:DMWD(gene name)|psi-mi:DMWD(display_short)|uniprotkb:DM9(gene name synonym) psi-mi:sucb2_human(display_long)|uniprotkb:SUCLG2(gene name)|psi-mi:SUCLG2(display_short)|uniprotkb:GTP-specific succinyl-CoA synthetase subunit beta(gene name synonym)|uniprotkb:Succinyl-CoA synthetase beta-G chain(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515767|imex:IM-12079-100 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004934.1|ensembl:ENSG00000185800(gene)|ensembl:ENST00000270223(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0030425"(dendrite)|go:"GO:0043204"(perikaryon)|interpro:IPR001680(WD40 repeat)|interpro:IPR036322|mint:Q09019 ensembl:ENSG00000172340(gene)|ensembl:ENST00000307227(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004775"("succinate-CoA ligase (ADP-forming) activity")|go:"GO:0004776"("succinate-CoA ligase (GDP-forming) activity")|go:"GO:0005524"(ATP binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005886"(plasma membrane)|go:"GO:0006099"(tricarboxylic acid cycle)|go:"GO:0006104"(succinyl-CoA metabolic process)|go:"GO:0006105"(succinate metabolic process)|go:"GO:0019003"(GDP binding)|go:"GO:0042709"(succinate-CoA ligase complex)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045244"("succinate-CoA ligase complex (GDP-forming)")|interpro:IPR005811(ATP-citrate lyase/succinyl-CoA ligase)|interpro:IPR013650(ATP-grasp fold, succinyl-CoA synthetase-type)|interpro:IPR013815(ATP-grasp fold, subdomain 1)|interpro:IPR005809(Succinyl-CoA synthetase, beta subunit)|interpro:IPR016102(Succinyl-CoA synthetase-like)|interpro:IPR017866|interpro:IPR034722|mint:Q96I99|rcsb pdb:6WCV|reactome:R-HSA-71403|refseq:NP_001171070.1|refseq:NP_003839.2|dip:DIP-53563N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:76SLwlB1ohLxjwUwpPOR6gT4DP89606 rogid:jxrFGuu3hFn2QAYfrPxTKhScM249606 intact-crc:6EEED496ABE106E9|rigid:7x4rJPiAytQVc5YAOqF/Q8i5j90 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q09019 uniprotkb:Q01813 intact:EBI-724564|ensembl:ENSP00000270223 intact:EBI-359022|uniprotkb:B3KS15|uniprotkb:Q5VSR7|uniprotkb:Q5VSR8|ensembl:ENSP00000370517 psi-mi:dmwd_human(display_long)|uniprotkb:Dystrophia myotonica-containing WD repeat motif protein(gene name synonym)|uniprotkb:Protein DMR-N9(gene name synonym)|uniprotkb:Protein 59(gene name synonym)|uniprotkb:DMWD(gene name)|psi-mi:DMWD(display_short)|uniprotkb:DM9(gene name synonym) psi-mi:pfkap_human(display_long)|uniprotkb:PFKP(gene name)|psi-mi:PFKP(display_short)|uniprotkb:PFKF(gene name synonym)|uniprotkb:Phosphohexokinase(gene name synonym)|uniprotkb:Phosphofructo-1-kinase isozyme C(gene name synonym)|uniprotkb:6-phosphofructokinase type C(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515767|imex:IM-12079-100 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004934.1|ensembl:ENSG00000185800(gene)|ensembl:ENST00000270223(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0030425"(dendrite)|go:"GO:0043204"(perikaryon)|interpro:IPR001680(WD40 repeat)|interpro:IPR036322|mint:Q09019 refseq:NP_002618.1|ensembl:ENSG00000067057(gene)|ensembl:ENST00000381125(transcript)|go:"GO:0003872"(6-phosphofructokinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005945"(6-phosphofructokinase complex)|go:"GO:0006002"(fructose 6-phosphate metabolic process)|go:"GO:0016020"(membrane)|go:"GO:0016208"(AMP binding)|go:"GO:0030388"(fructose 1,6-bisphosphate metabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048029"(monosaccharide binding)|go:"GO:0061621"(canonical glycolysis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070095"(fructose-6-phosphate binding)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR000023(Phosphofructokinase)|interpro:IPR009161(6-phosphofructokinase, eukaryotic type)|interpro:IPR015912(Phosphofructokinase, conserved site)|interpro:IPR022953|interpro:IPR035966|interpro:IPR041914|mint:Q01813|rcsb pdb:4RH3|rcsb pdb:4U1R|rcsb pdb:4WL0|rcsb pdb:4XYJ|rcsb pdb:4XYK|rcsb pdb:4XZ2|reactome:R-HSA-70171|refseq:NP_001229268.1|dip:DIP-45850N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:76SLwlB1ohLxjwUwpPOR6gT4DP89606 rogid:GNmWbFrQsTMRdVphWG+3DK3wxaA9606 intact-crc:6EEED496ABE106E9|rigid:7x4rJPiAytQVc5YAOqF/Q8i5j90 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q09019 uniprotkb:P02768 intact:EBI-724564|ensembl:ENSP00000270223 intact:EBI-714423|ensembl:ENSP00000295897|uniprotkb:Q645G4|uniprotkb:O95574|uniprotkb:P04277|uniprotkb:Q13140|uniprotkb:Q68DN5|uniprotkb:Q6UXK4|uniprotkb:Q86YG0|uniprotkb:Q9P157|uniprotkb:Q9P1I7|uniprotkb:Q9UHS3|uniprotkb:Q9UJZ0|intact:EBI-7301844|intact:MINT-1161169|uniprotkb:E7ESS9|uniprotkb:Q8IUK7 psi-mi:dmwd_human(display_long)|uniprotkb:Dystrophia myotonica-containing WD repeat motif protein(gene name synonym)|uniprotkb:Protein DMR-N9(gene name synonym)|uniprotkb:Protein 59(gene name synonym)|uniprotkb:DMWD(gene name)|psi-mi:DMWD(display_short)|uniprotkb:DM9(gene name synonym) psi-mi:albu_human(display_long)|uniprotkb:GIG42(orf name)|uniprotkb:ALB(gene name)|psi-mi:ALB(display_short)|uniprotkb:PRO0903(orf name)|uniprotkb:PRO1708(orf name)|uniprotkb:PRO2044(orf name)|uniprotkb:PRO2619(orf name)|uniprotkb:PRO2675(orf name)|uniprotkb:UNQ696/PRO1341(orf name)|uniprotkb:GIG20(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515767|imex:IM-12079-100 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004934.1|ensembl:ENSG00000185800(gene)|ensembl:ENST00000270223(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0030425"(dendrite)|go:"GO:0043204"(perikaryon)|interpro:IPR001680(WD40 repeat)|interpro:IPR036322|mint:Q09019 ensembl:ENSG00000163631(gene)|ensembl:ENST00000295897(transcript)|go:"GO:0001895"(retina homeostasis)|go:"GO:0003677"(DNA binding)|go:"GO:0005504"(fatty acid binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|rcsb pdb:1E78|go:"GO:0005634"(nucleus)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0015643"(toxic substance binding)|go:"GO:0016209"(antioxidant activity)|go:"GO:0030170"(pyridoxal phosphate binding)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043069"(negative regulation of programmed cell death)|go:"GO:0051087"(chaperone binding)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0051659"(maintenance of mitochondrion location)|go:"GO:0070062"(extracellular exosome)|go:"GO:0072562"(blood microparticle)|go:"GO:0140272"(exogenous protein binding)|go:"GO:1903981"(enterobactin binding)|interpro:IPR000264(Serum albumin)|interpro:IPR014760(Serum albumin, N-terminal)|interpro:IPR020857|interpro:IPR020858|interpro:IPR021177|mint:P02768|rcsb pdb:1AO6|rcsb pdb:1BJ5|rcsb pdb:1BKE|rcsb pdb:1BM0|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|rcsb pdb:6XV0|rcsb pdb:6YG9|rcsb pdb:6ZL1|rcsb pdb:7A9C|rcsb pdb:7AAE|rcsb pdb:7AAI|rcsb pdb:7D6J|rcsb pdb:7JWN|reactome:R-HSA-114608|reactome:R-HSA-159418|reactome:R-HSA-189451|reactome:R-HSA-189483|reactome:R-HSA-2168880|reactome:R-HSA-381426|reactome:R-HSA-879518|reactome:R-HSA-8957275|reactome:R-HSA-8964058|reactome:R-HSA-9707564|rcsb pdb:6WUW|rcsb pdb:1E7B|rcsb pdb:1E7C|rcsb pdb:1E7E|rcsb pdb:1E7F|rcsb pdb:1E7G|rcsb pdb:1E7H|rcsb pdb:1E7I|rcsb pdb:1GNI|rcsb pdb:1GNJ|rcsb pdb:1H9Z|rcsb pdb:1HA2|rcsb pdb:1HK1|rcsb pdb:1HK2|rcsb pdb:1HK3|rcsb pdb:1HK4|rcsb pdb:1HK5|rcsb pdb:1N5U|rcsb pdb:1O9X|rcsb pdb:1TF0|rcsb pdb:1UOR|rcsb pdb:1YSX|rcsb pdb:2BX8|rcsb pdb:2BXA|rcsb pdb:2BXB|rcsb pdb:2BXC|rcsb pdb:2BXD|rcsb pdb:1E7A|rcsb pdb:2BXE|rcsb pdb:2BXF|rcsb pdb:2BXG|rcsb pdb:2BXH|rcsb pdb:2BXI|rcsb pdb:2BXK|rcsb pdb:2BXL|rcsb pdb:2BXM|rcsb pdb:2BXN|rcsb pdb:2BXO|rcsb pdb:2BXP|rcsb pdb:2BXQ|rcsb pdb:2ESG|rcsb pdb:2I2Z|rcsb pdb:2I30|rcsb pdb:2N0X|rcsb pdb:2VDB|rcsb pdb:2VUE|rcsb pdb:2VUF|rcsb pdb:2XSI|rcsb pdb:2XVQ|rcsb pdb:2XVU|rcsb pdb:2XVV|rcsb pdb:2XVW|rcsb pdb:2XW0|rcsb pdb:2XW1|rcsb pdb:2YDF|rcsb pdb:3A73|rcsb pdb:3B9L|rcsb pdb:3B9M|rcsb pdb:3CX9|rcsb pdb:3JQZ|rcsb pdb:3JRY|rcsb pdb:3LU6|rcsb pdb:4HGM|rcsb pdb:4IW1|rcsb pdb:4IW2|rcsb pdb:4K2C|rcsb pdb:4K71|rcsb pdb:4L8U|rcsb pdb:4L9K|rcsb pdb:4L9Q|rcsb pdb:4LA0|rcsb pdb:4LB2|rcsb pdb:4LB9|rcsb pdb:4N0F|rcsb pdb:4N0U|rcsb pdb:4S1Y|rcsb pdb:4Z69|rcsb pdb:5FUO|rcsb pdb:5GIX|rcsb pdb:5GIY|rcsb pdb:5ID7|rcsb pdb:5IFO|rcsb pdb:5IJF|rcsb pdb:5UJB|rcsb pdb:5VNW|rcsb pdb:5X52|rcsb pdb:5YB1|rcsb pdb:5YOQ|rcsb pdb:5Z0B|rcsb pdb:6A7P|rcsb pdb:6EZQ|rcsb pdb:6HSC|rcsb pdb:6JE7|rcsb pdb:6L4K|rcsb pdb:6M4R|rcsb pdb:3LU7|rcsb pdb:3LU8|rcsb pdb:3SQJ|rcsb pdb:3TDL|rcsb pdb:3UIV|rcsb pdb:4BKE|rcsb pdb:4E99|rcsb pdb:4EMX|rcsb pdb:4G03|rcsb pdb:4G04|rcsb pdb:4HGK|rcsb pdb:6M58|rcsb pdb:6M5D|rcsb pdb:6M5E|rcsb pdb:6QIO|rcsb pdb:6QIP|rcsb pdb:6R7S|refseq:NP_000468.1|dip:DIP-29902N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:76SLwlB1ohLxjwUwpPOR6gT4DP89606 rogid:kjtn5mBsCZz/NRkcyW5k3ZWeJBU9606 intact-crc:6EEED496ABE106E9|rigid:7x4rJPiAytQVc5YAOqF/Q8i5j90 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q09019 uniprotkb:Q99598 intact:EBI-724564|ensembl:ENSP00000270223 intact:EBI-742638|intact:EBI-1050136|uniprotkb:B1APC6|refseq:NP_005990|dip:DIP-29463N psi-mi:dmwd_human(display_long)|uniprotkb:Dystrophia myotonica-containing WD repeat motif protein(gene name synonym)|uniprotkb:Protein DMR-N9(gene name synonym)|uniprotkb:Protein 59(gene name synonym)|uniprotkb:DMWD(gene name)|psi-mi:DMWD(display_short)|uniprotkb:DM9(gene name synonym) psi-mi:tsnax_human(display_long)|uniprotkb:Translin-associated factor X(gene name synonym)|uniprotkb:TSNAX(gene name)|psi-mi:TSNAX(display_short)|uniprotkb:TRAX(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515767|imex:IM-12079-100 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004934.1|ensembl:ENSG00000185800(gene)|ensembl:ENST00000270223(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0030425"(dendrite)|go:"GO:0043204"(perikaryon)|interpro:IPR001680(WD40 repeat)|interpro:IPR036322|mint:Q09019 go:"GO:0005634"(nucleus)|go:"GO:0008565"(obsolete protein transporter activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0007275"(multicellular organism development)|go:"GO:0007283"(spermatogenesis)|refseq:NP_005990.1|interpro:IPR002848(Translin)|interpro:IPR016068(Translin, N-terminal)|rcsb pdb:3PJA|rcsb pdb:3QB5|ensembl:ENST00000366639|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0031047"(gene silencing by RNA)|reactome:R-HSA-426486|go:"GO:0030422"(production of siRNA involved in RNA interference)|interpro:IPR036081|go:"GO:0003677"(DNA binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0046872"(metal ion binding)|go:"GO:0005829"(cytosol)|ensembl:ENSG00000116918|ensembl:ENSP00000355599|go:"GO:0005654"(nucleoplasm)|go:"GO:0003723"(RNA binding)|dip:DIP-29463N|mint:MINT-1347706|go:"GO:0044822"|interpro:IPR016069(Translin, C-terminal)|go:"GO:0031687"(A2A adenosine receptor binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0004521"(endoribonuclease activity)|go:"GO:0003697"(single-stranded DNA binding) psi-mi:"MI:0469"(intact) - crc64:D38B0DD96B50C0B9|no-uniprot-update:|caution:"The protein could not be merged with EBI-12908040 because of some conflicts with the protein sequence (features which cannot be shifted)." figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:76SLwlB1ohLxjwUwpPOR6gT4DP89606 rogid:TaNIxjLHGusdq32WbdJ21DG9yBQ9606 intact-crc:6EEED496ABE106E9|rigid:7x4rJPiAytQVc5YAOqF/Q8i5j90 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q09019 uniprotkb:O75317 intact:EBI-724564|ensembl:ENSP00000270223 intact:EBI-2511507|ensembl:ENSP00000282344|uniprotkb:Q8TC49|uniprotkb:Q5VZV3|uniprotkb:A8K0X0 psi-mi:dmwd_human(display_long)|uniprotkb:Dystrophia myotonica-containing WD repeat motif protein(gene name synonym)|uniprotkb:Protein DMR-N9(gene name synonym)|uniprotkb:Protein 59(gene name synonym)|uniprotkb:DMWD(gene name)|psi-mi:DMWD(display_short)|uniprotkb:DM9(gene name synonym) psi-mi:ubp12_human(display_long)|uniprotkb:USP12(gene name)|psi-mi:USP12(display_short)|uniprotkb:UBH1(gene name synonym)|uniprotkb:USP12L1(gene name synonym)|uniprotkb:Ubiquitin-specific-processing protease 12(gene name synonym)|uniprotkb:Deubiquitinating enzyme 12(gene name synonym)|uniprotkb:Ubiquitin-hydrolyzing enzyme 1(gene name synonym)|uniprotkb:Ubiquitin thioesterase 12(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515767|imex:IM-12079-100 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004934.1|ensembl:ENSG00000185800(gene)|ensembl:ENST00000270223(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0030425"(dendrite)|go:"GO:0043204"(perikaryon)|interpro:IPR001680(WD40 repeat)|interpro:IPR036322|mint:Q09019 ensembl:ENSG00000152484(gene)|ensembl:ENST00000282344(transcript)|go:"GO:0004197"(cysteine-type endopeptidase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0046872"(metal ion binding)|interpro:IPR001394(Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2)|interpro:IPR018200|interpro:IPR028889|interpro:IPR038765|mint:O75317|rcsb pdb:5K16|rcsb pdb:5K1A|rcsb pdb:5K1B|rcsb pdb:5K1C|rcsb pdb:5L8W|reactome:R-HSA-5689880|refseq:NP_872294.2 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:76SLwlB1ohLxjwUwpPOR6gT4DP89606 rogid:SiueMBicjAsFl2OGlBfQ6tg1cf89606 intact-crc:6EEED496ABE106E9|rigid:7x4rJPiAytQVc5YAOqF/Q8i5j90 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q09019 uniprotkb:Q04917 intact:EBI-724564|ensembl:ENSP00000270223 intact:EBI-306940|ensembl:ENSP00000248975|intact:EBI-11759595 psi-mi:dmwd_human(display_long)|uniprotkb:Dystrophia myotonica-containing WD repeat motif protein(gene name synonym)|uniprotkb:Protein DMR-N9(gene name synonym)|uniprotkb:Protein 59(gene name synonym)|uniprotkb:DMWD(gene name)|psi-mi:DMWD(display_short)|uniprotkb:DM9(gene name synonym) psi-mi:1433f_human(display_long)|uniprotkb:YWHAH(gene name)|psi-mi:YWHAH(display_short)|uniprotkb:YWHA1(gene name synonym)|uniprotkb:Protein AS1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515767|imex:IM-12079-100 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004934.1|ensembl:ENSG00000185800(gene)|ensembl:ENST00000270223(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0030425"(dendrite)|go:"GO:0043204"(perikaryon)|interpro:IPR001680(WD40 repeat)|interpro:IPR036322|mint:Q09019 go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0050774"(negative regulation of dendrite morphogenesis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0086010"(membrane depolarization during action potential)|go:"GO:2000649"(regulation of sodium ion transmembrane transporter activity)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:Q04917|rcsb pdb:2C63|rcsb pdb:2C74|reactome:R-HSA-111447|reactome:R-HSA-1445148|reactome:R-HSA-5625740|reactome:R-HSA-5628897|reactome:R-HSA-75035|ensembl:ENSG00000128245(gene)|ensembl:ENST00000248975(transcript)|go:"GO:0002028"(regulation of sodium ion transport)|go:"GO:0003779"(actin binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006713"(glucocorticoid catabolic process)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0014704"(intercalated disc)|go:"GO:0017080"(sodium channel regulator activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021762"(substantia nigra development)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0042921"(glucocorticoid receptor signaling pathway)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|refseq:NP_003396.1|dip:DIP-27566N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:76SLwlB1ohLxjwUwpPOR6gT4DP89606 rogid:VhFYPSsW3IRC388FTlmwwN37HnU9606 intact-crc:6EEED496ABE106E9|rigid:7x4rJPiAytQVc5YAOqF/Q8i5j90 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q09019 uniprotkb:Q8TAF3 intact:EBI-724564|ensembl:ENSP00000270223 intact:EBI-1045469|uniprotkb:Q63HJ2|uniprotkb:Q658Y1|uniprotkb:Q8N3Z1|uniprotkb:Q9NSK8|uniprotkb:Q9P279|uniprotkb:B4DM86|uniprotkb:B4DQI2|uniprotkb:B4DY84|ensembl:ENSP00000307491 psi-mi:dmwd_human(display_long)|uniprotkb:Dystrophia myotonica-containing WD repeat motif protein(gene name synonym)|uniprotkb:Protein DMR-N9(gene name synonym)|uniprotkb:Protein 59(gene name synonym)|uniprotkb:DMWD(gene name)|psi-mi:DMWD(display_short)|uniprotkb:DM9(gene name synonym) psi-mi:wdr48_human(display_long)|uniprotkb:WD repeat endosomal protein(gene name synonym)|uniprotkb:p80(gene name synonym)|uniprotkb:WDR48(gene name)|psi-mi:WDR48(display_short)|uniprotkb:KIAA1449(gene name synonym)|uniprotkb:UAF1(gene name synonym)|uniprotkb:USP1-associated factor 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515767|imex:IM-12079-100 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004934.1|ensembl:ENSG00000185800(gene)|ensembl:ENST00000270223(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0030425"(dendrite)|go:"GO:0043204"(perikaryon)|interpro:IPR001680(WD40 repeat)|interpro:IPR036322|mint:Q09019 refseq:NP_065890.1|ensembl:ENSG00000114742(gene)|ensembl:ENST00000302313(transcript)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0003677"(DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043588"(skin development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048705"(skeletal system morphogenesis)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0072520"(seminiferous tubule development)|go:"GO:1902525"(regulation of protein monoubiquitination)|go:"GO:1903003"(positive regulation of protein deubiquitination)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR021772|interpro:IPR036322|mint:Q8TAF3|rcsb pdb:5CVL|rcsb pdb:5CVN|rcsb pdb:5CVO|rcsb pdb:5K1A|rcsb pdb:5K1B|rcsb pdb:5K1C|rcsb pdb:5L8E|rcsb pdb:5L8W|rcsb pdb:6JLQ|rcsb pdb:7AY0|rcsb pdb:7AY1|rcsb pdb:7AY2|reactome:R-HSA-110314|reactome:R-HSA-5689880|reactome:R-HSA-6783310|reactome:R-HSA-9673766|refseq:NP_001290331.1|refseq:NP_001290332.1|refseq:NP_001333156.1|refseq:NP_001333157.1|dip:DIP-50841N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:76SLwlB1ohLxjwUwpPOR6gT4DP89606 rogid:S8ihl3jxEEyMS46AM2ynXSFfCU49606 intact-crc:6EEED496ABE106E9|rigid:7x4rJPiAytQVc5YAOqF/Q8i5j90 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q09019 uniprotkb:O75306 intact:EBI-724564|ensembl:ENSP00000270223 intact:EBI-1224806|uniprotkb:Q5VTW0|uniprotkb:Q969P3|uniprotkb:Q9UEV3|uniprotkb:J3KPM7|uniprotkb:D3DVG7|intact:EBI-11120296|intact:EBI-28971126|ensembl:ENSP00000356972|ensembl:ENSP00000503117|ensembl:ENSP00000503989|ensembl:ENSP00000504199|ensembl:ENSP00000504846 psi-mi:dmwd_human(display_long)|uniprotkb:Dystrophia myotonica-containing WD repeat motif protein(gene name synonym)|uniprotkb:Protein DMR-N9(gene name synonym)|uniprotkb:Protein 59(gene name synonym)|uniprotkb:DMWD(gene name)|psi-mi:DMWD(display_short)|uniprotkb:DM9(gene name synonym) psi-mi:ndus2_human(display_long)|uniprotkb:NDUFS2(gene name)|psi-mi:NDUFS2(display_short)|uniprotkb:NADH-ubiquinone oxidoreductase 49 kDa subunit(gene name synonym)|uniprotkb:Complex I-49kD(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515767|imex:IM-12079-100 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004934.1|ensembl:ENSG00000185800(gene)|ensembl:ENST00000270223(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0030425"(dendrite)|go:"GO:0043204"(perikaryon)|interpro:IPR001680(WD40 repeat)|interpro:IPR036322|mint:Q09019 ensembl:ENSP00000356972|ensembl:ENST00000392179|ensembl:ENSP00000376018|ensembl:ENSP00000503117|ensembl:ENSP00000503989|ensembl:ENST00000677457|ensembl:ENSP00000503294|ensembl:ENST00000677550|ensembl:ENSP00000503353|ensembl:ENSP00000504199|ensembl:ENSP00000504846|ensembl:ENST00000678605|ensembl:ENSP00000503969|ensembl:ENST00000679176|ensembl:ENSP00000504170|refseq:NP_001159631.1|refseq:NP_004541.1|refseq:XP_005245265.1|refseq:XP_016856846.1|ensembl:ENST00000676600(transcript)|ensembl:ENST00000676972(transcript)|ensembl:ENST00000678507(transcript)|ensembl:ENST00000678511(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005747"(mitochondrial respiratory chain complex I)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006120"(mitochondrial electron transport, NADH to ubiquinone)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0008137"("NADH dehydrogenase (ubiquinone) activity")|go:"GO:0009055"(electron transfer activity)|go:"GO:0019826"(oxygen sensor activity)|go:"GO:0022008"(neurogenesis)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032981"(mitochondrial respiratory chain complex I assembly)|go:"GO:0042063"(gliogenesis)|go:"GO:0042775"(mitochondrial ATP synthesis coupled electron transport)|go:"GO:0046872"(metal ion binding)|ensembl:ENST00000367993(transcript)|go:"GO:0048038"(quinone binding)|go:"GO:0051287"(NAD binding)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0061351"(neural precursor cell proliferation)|go:"GO:0071453"(cellular response to oxygen levels)|interpro:IPR001135(NADH-ubiquinone oxidoreductase, chain 49kDa)|interpro:IPR014029(NADH-ubiquinone oxidoreductase, chain 49kDa, conserved site)|interpro:IPR022885|interpro:IPR029014|mint:O75306|rcsb pdb:5XTB|rcsb pdb:5XTC|rcsb pdb:5XTD|rcsb pdb:5XTH|rcsb pdb:5XTI|reactome:R-HSA-611105|reactome:R-HSA-6799198|ensembl:ENSG00000158864(gene) psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:76SLwlB1ohLxjwUwpPOR6gT4DP89606 rogid:ZyGea/CEJ7g/u+3D7SXTtLUAnRY9606 intact-crc:6EEED496ABE106E9|rigid:7x4rJPiAytQVc5YAOqF/Q8i5j90 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q09019 uniprotkb:Q9NP81 intact:EBI-724564|ensembl:ENSP00000270223 intact:EBI-1049768|uniprotkb:A6NHW7|uniprotkb:Q9BVP3|uniprotkb:B4DE10|ensembl:ENSP00000221431|ensembl:ENSP00000489539 psi-mi:dmwd_human(display_long)|uniprotkb:Dystrophia myotonica-containing WD repeat motif protein(gene name synonym)|uniprotkb:Protein DMR-N9(gene name synonym)|uniprotkb:Protein 59(gene name synonym)|uniprotkb:DMWD(gene name)|psi-mi:DMWD(display_short)|uniprotkb:DM9(gene name synonym) psi-mi:sysm_human(display_long)|uniprotkb:"Seryl-tRNA(Ser/Sec) synthetase"(gene name synonym)|uniprotkb:SerRSmt(gene name synonym)|uniprotkb:SARS2(gene name)|psi-mi:SARS2(display_short)|uniprotkb:SARSM(gene name synonym)|uniprotkb:Seryl-tRNA synthetase(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515767|imex:IM-12079-100 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004934.1|ensembl:ENSG00000185800(gene)|ensembl:ENST00000270223(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0030425"(dendrite)|go:"GO:0043204"(perikaryon)|interpro:IPR001680(WD40 repeat)|interpro:IPR036322|mint:Q09019 refseq:NP_001139373.1|refseq:NP_060297.1|interpro:IPR002317(Seryl-tRNA synthetase, class IIa)|interpro:IPR006195(Aminoacyl-tRNA synthetase, class II)|interpro:IPR010978(tRNA-binding arm)|interpro:IPR033729|interpro:IPR042103|mint:Q9NP81|interpro:IPR002314("Aminoacyl-tRNA synthetase, class II (G, H, P and S)")|reactome:R-HSA-379726|ensembl:ENSG00000104835(gene)|ensembl:ENSG00000283104(gene)|ensembl:ENST00000221431(transcript)|ensembl:ENST00000634687(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004828"(serine-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006434"(seryl-tRNA aminoacylation)|go:"GO:0070158"(mitochondrial seryl-tRNA aminoacylation)|go:"GO:0097056"("selenocysteinyl-tRNA(Sec) biosynthetic process") psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:76SLwlB1ohLxjwUwpPOR6gT4DP89606 rogid:xYa2ZQIifKicNHV/6vlcUGaN9q49606 intact-crc:6EEED496ABE106E9|rigid:7x4rJPiAytQVc5YAOqF/Q8i5j90 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q09019 uniprotkb:P47756 intact:EBI-724564|ensembl:ENSP00000270223 intact:EBI-353595|uniprotkb:Q5U0L4|uniprotkb:Q8TB49|uniprotkb:Q9NUC4|uniprotkb:Q32Q68|ensembl:ENSP00000364284|ensembl:ENSP00000501528 psi-mi:dmwd_human(display_long)|uniprotkb:Dystrophia myotonica-containing WD repeat motif protein(gene name synonym)|uniprotkb:Protein DMR-N9(gene name synonym)|uniprotkb:Protein 59(gene name synonym)|uniprotkb:DMWD(gene name)|psi-mi:DMWD(display_short)|uniprotkb:DM9(gene name synonym) psi-mi:capzb_human(display_long)|uniprotkb:CAPZB(gene name)|psi-mi:CAPZB(display_short)|uniprotkb:CapZ beta(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515767|imex:IM-12079-100 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004934.1|ensembl:ENSG00000185800(gene)|ensembl:ENST00000270223(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0030425"(dendrite)|go:"GO:0043204"(perikaryon)|interpro:IPR001680(WD40 repeat)|interpro:IPR036322|mint:Q09019 refseq:NP_001193469.1|refseq:NP_004921.1|go:"GO:0045296"(cadherin binding)|go:"GO:0051015"(actin filament binding)|go:"GO:0051016"(barbed-end actin filament capping)|go:"GO:0051490"(negative regulation of filopodium assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071203"(WASH complex)|go:"GO:0097224"(sperm connecting piece)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|interpro:IPR001698(F-actin capping protein, beta subunit)|interpro:IPR019771|interpro:IPR037282|interpro:IPR042276|interpro:IPR043175|mint:P47756|reactome:R-HSA-2132295|reactome:R-HSA-3371497|reactome:R-HSA-6807878|reactome:R-HSA-6811436|reactome:R-HSA-9013405|reactome:R-HSA-9035034|reactome:R-HSA-9662360|reactome:R-HSA-983231|ensembl:ENSG00000077549(gene)|ensembl:ENST00000375142(transcript)|ensembl:ENST00000674432(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005903"(brush border)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0008290"(F-actin capping protein complex)|go:"GO:0010591"(regulation of lamellipodium assembly)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0022604"(regulation of cell morphogenesis)|go:"GO:0030017"(sarcomere)|go:"GO:0030027"(lamellipodium)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030863"(cortical cytoskeleton)|refseq:NP_001269091.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:76SLwlB1ohLxjwUwpPOR6gT4DP89606 rogid:qRXsrB2fLT1DMVIVRWKFYe4Aln49606 intact-crc:6EEED496ABE106E9|rigid:7x4rJPiAytQVc5YAOqF/Q8i5j90 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q09019 uniprotkb:P04181 intact:EBI-724564|ensembl:ENSP00000270223 intact:EBI-721662|uniprotkb:Q68CS0|uniprotkb:Q16068|uniprotkb:Q16069|uniprotkb:Q9UD03|intact:EBI-1237002|uniprotkb:Q6IAV9|uniprotkb:D3DRF0|ensembl:ENSP00000357838 psi-mi:dmwd_human(display_long)|uniprotkb:Dystrophia myotonica-containing WD repeat motif protein(gene name synonym)|uniprotkb:Protein DMR-N9(gene name synonym)|uniprotkb:Protein 59(gene name synonym)|uniprotkb:DMWD(gene name)|psi-mi:DMWD(display_short)|uniprotkb:DM9(gene name synonym) psi-mi:oat_human(display_long)|uniprotkb:Ornithine--oxo-acid aminotransferase(gene name synonym)|uniprotkb:OAT(gene name)|psi-mi:OAT(display_short)|uniprotkb:Ornithine delta-aminotransferase(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515767|imex:IM-12079-100 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004934.1|ensembl:ENSG00000185800(gene)|ensembl:ENST00000270223(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0030425"(dendrite)|go:"GO:0043204"(perikaryon)|interpro:IPR001680(WD40 repeat)|interpro:IPR036322|mint:Q09019 refseq:NP_000265.1|refseq:NP_001165285.1|refseq:NP_001309894.1|refseq:NP_001309895.1|refseq:NP_001309896.1|refseq:NP_001309897.1|refseq:NP_001309898.1|refseq:NP_001309899.1|refseq:NP_001309900.1|rcsb pdb:6OIA|rcsb pdb:6V8C|rcsb pdb:6V8D|rcsb pdb:7JX9|reactome:R-HSA-8964539|ensembl:ENSG00000065154(gene)|ensembl:ENST00000368845(transcript)|go:"GO:0004587"(ornithine-oxo-acid transaminase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0007601"(visual perception)|go:"GO:0010121"(arginine catabolic process to proline via ornithine)|go:"GO:0019544"(arginine catabolic process to glutamate)|go:"GO:0030170"(pyridoxal phosphate binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0050155"("ornithine(lysine) transaminase activity")|go:"GO:0055129"(L-proline biosynthetic process)|interpro:IPR005814(Aminotransferase class-III)|interpro:IPR010164(Ornithine aminotransferase)|interpro:IPR015421(Pyridoxal phosphate-dependent transferase, major region, subdomain 1)|interpro:IPR015422(Pyridoxal phosphate-dependent transferase, major region, subdomain 2)|interpro:IPR015424(Pyridoxal phosphate-dependent transferase, major region)|rcsb pdb:1GBN|rcsb pdb:1OAT|rcsb pdb:2BYJ|rcsb pdb:2BYL|rcsb pdb:2CAN|rcsb pdb:2OAT|rcsb pdb:5VWO|rcsb pdb:6HX7 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:76SLwlB1ohLxjwUwpPOR6gT4DP89606 rogid:j+e5fOgz5Yv7lLp2NV8Uq+eR6909606 intact-crc:6EEED496ABE106E9|rigid:7x4rJPiAytQVc5YAOqF/Q8i5j90 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:Q09019 uniprotkb:Q99470 intact:EBI-724564|ensembl:ENSP00000270223 intact:EBI-2515769|ensembl:ENSP00000247020|uniprotkb:Q9BQ79 psi-mi:dmwd_human(display_long)|uniprotkb:Dystrophia myotonica-containing WD repeat motif protein(gene name synonym)|uniprotkb:Protein DMR-N9(gene name synonym)|uniprotkb:Protein 59(gene name synonym)|uniprotkb:DMWD(gene name)|psi-mi:DMWD(display_short)|uniprotkb:DM9(gene name synonym) psi-mi:sdf2_human(display_long)|uniprotkb:SDF2(gene name)|psi-mi:SDF2(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515767|imex:IM-12079-100 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_004934.1|ensembl:ENSG00000185800(gene)|ensembl:ENST00000270223(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0030425"(dendrite)|go:"GO:0043204"(perikaryon)|interpro:IPR001680(WD40 repeat)|interpro:IPR036322|mint:Q09019 ensembl:ENSG00000132581(gene)|ensembl:ENST00000247020(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0051085"(chaperone cofactor-dependent protein refolding)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0101031"(chaperone complex)|interpro:IPR016093(MIR motif)|interpro:IPR036300|refseq:NP_008854.2 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:76SLwlB1ohLxjwUwpPOR6gT4DP89606 rogid:j0jeyDbvcmC8s+1awSiR7K/hyxo9606 intact-crc:6EEED496ABE106E9|rigid:7x4rJPiAytQVc5YAOqF/Q8i5j90 false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P11441 uniprotkb:Q7Z6Z7 intact:EBI-356983|uniprotkb:Q5HY80|ensembl:ENSP00000358674 intact:EBI-625934|uniprotkb:O15029|uniprotkb:Q4G2Z2|uniprotkb:Q5H961|uniprotkb:Q6P4D0|uniprotkb:Q8NG67|uniprotkb:Q9BUI0|uniprotkb:Q9HCJ4|uniprotkb:Q9NSL6|uniprotkb:Q9P0A9|ensembl:ENSP00000262854|ensembl:ENSP00000340648 psi-mi:ubl4a_human(display_long)|uniprotkb:UBL4A(gene name)|psi-mi:UBL4A(display_short)|uniprotkb:GDX(gene name synonym)|uniprotkb:DXS254E(gene name synonym)|uniprotkb:UBL4(gene name synonym)|uniprotkb:Ubiquitin-like protein GDX(gene name synonym) psi-mi:huwe1_human(display_long)|uniprotkb:HECT, UBA and WWE domain-containing protein 1(gene name synonym)|uniprotkb:Upstream regulatory element-binding protein 1(gene name synonym)|uniprotkb:Mcl-1 ubiquitin ligase E3(gene name synonym)|uniprotkb:ARF-binding protein 1(gene name synonym)|uniprotkb:Large structure of UREB1(gene name synonym)|uniprotkb:Homologous to E6AP carboxyl terminus homologous protein 9(gene name synonym)|uniprotkb:HUWE1(gene name)|psi-mi:HUWE1(display_short)|uniprotkb:KIAA0312(gene name synonym)|uniprotkb:KIAA1578(gene name synonym)|uniprotkb:HSPC272(orf name)|uniprotkb:HECT-type E3 ubiquitin transferase HUWE1(gene name synonym)|uniprotkb:UREB1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515855|imex:IM-12079-50 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055050.1|ensembl:ENSG00000102178(gene)|ensembl:ENST00000369660(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0016020"(membrane)|go:"GO:0019787"(ubiquitin-like protein transferase activity)|go:"GO:0051087"(chaperone binding)|go:"GO:0071816"(tail-anchored membrane protein insertion into ER membrane)|go:"GO:0071818"(BAT3 complex)|interpro:IPR000626(Ubiquitin)|interpro:IPR019954|interpro:IPR019956|interpro:IPR029071|interpro:IPR041421|interpro:IPR044724|mint:P11441|rcsb pdb:2DZI|rcsb pdb:4WWR|rcsb pdb:4X86|reactome:R-HSA-9609523 ensembl:ENSG00000086758(gene)|ensembl:ENST00000262854(transcript)|ensembl:ENST00000342160(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006284"(base-excision repair)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0007030"(Golgi organization)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016020"(membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0030154"(cell differentiation)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0034774"(secretory granule lumen)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|go:"GO:1903955"(positive regulation of protein targeting to mitochondrion)|go:"GO:1904813"(ficolin-1-rich granule lumen)|interpro:IPR000569(HECT)|interpro:IPR004170(WWE)|interpro:IPR009060(UBA-like)|interpro:IPR010309(E3 ubiquitin ligase, region of unknown function DUF908)|interpro:IPR010314(E3 ubiquitin ligase, region of unknown function DUF913)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR025527|interpro:IPR035983|interpro:IPR037197|interpro:IPR041918|mint:Q7Z6Z7|rcsb pdb:2EKK|rcsb pdb:2MUL|rcsb pdb:3G1N|go:"GO:0061025"(membrane fusion)|rcsb pdb:5C6H|rcsb pdb:5LP8|rcsb pdb:6FYH|rcsb pdb:6MIW|rcsb pdb:6PFL|reactome:R-HSA-6798695|rcsb pdb:3H1D|reactome:R-HSA-983168|refseq:NP_113584.3|refseq:XP_005262022.1|dip:DIP-34362N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:euKOrDRC1mx0s2QVY95010PRaIg9606 rogid:TnIn0mcFc81bJlMkyWTtq3n/uOg9606 intact-crc:27E6D0D5B21DF7F8|rigid:btXzwXs83VnmPgYBYgUyjhq2K+w false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P11441 uniprotkb:O43765 intact:EBI-356983|uniprotkb:Q5HY80|ensembl:ENSP00000358674 intact:EBI-347996|ensembl:ENSP00000221566|ensembl:ENSP00000503397|ensembl:ENSP00000504495|uniprotkb:Q9BTZ9|intact:EBI-1045243|uniprotkb:Q6FIA9|uniprotkb:D6W610 psi-mi:ubl4a_human(display_long)|uniprotkb:UBL4A(gene name)|psi-mi:UBL4A(display_short)|uniprotkb:GDX(gene name synonym)|uniprotkb:DXS254E(gene name synonym)|uniprotkb:UBL4(gene name synonym)|uniprotkb:Ubiquitin-like protein GDX(gene name synonym) psi-mi:sgta_human(display_long)|uniprotkb:SGTA(gene name)|psi-mi:SGTA(display_short)|uniprotkb:SGT(gene name synonym)|uniprotkb:Alpha-SGT(gene name synonym)|uniprotkb:Vpu-binding protein(gene name synonym)|uniprotkb:SGT1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515855|imex:IM-12079-50 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055050.1|ensembl:ENSG00000102178(gene)|ensembl:ENST00000369660(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0016020"(membrane)|go:"GO:0019787"(ubiquitin-like protein transferase activity)|go:"GO:0051087"(chaperone binding)|go:"GO:0071816"(tail-anchored membrane protein insertion into ER membrane)|go:"GO:0071818"(BAT3 complex)|interpro:IPR000626(Ubiquitin)|interpro:IPR019954|interpro:IPR019956|interpro:IPR029071|interpro:IPR041421|interpro:IPR044724|mint:P11441|rcsb pdb:2DZI|rcsb pdb:4WWR|rcsb pdb:4X86|reactome:R-HSA-9609523 rcsb pdb:4CPG|rcsb pdb:4GOD|rcsb pdb:4GOE|rcsb pdb:4GOF|reactome:R-HSA-9609523|rcsb pdb:2VYI|ensembl:ENSG00000104969(gene)|ensembl:ENST00000221566(transcript)|ensembl:ENST00000676943(transcript)|ensembl:ENST00000677149(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006620"(posttranslational protein targeting to endoplasmic reticulum membrane)|go:"GO:0016020"(membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043621"(protein self-association)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0071816"(tail-anchored membrane protein insertion into ER membrane)|go:"GO:0072380"(TRC complex)|go:"GO:0098850"(extrinsic component of synaptic vesicle membrane)|go:"GO:1903070"(negative regulation of ER-associated ubiquitin-dependent protein catabolic process)|go:"GO:1903071"(positive regulation of ER-associated ubiquitin-dependent protein catabolic process)|go:"GO:1903646"(positive regulation of chaperone-mediated protein folding)|go:"GO:1904288"(BAT3 complex binding)|go:"GO:2000059"(negative regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR032374|mint:O43765|refseq:XP_011526480.1|refseq:NP_003012.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:euKOrDRC1mx0s2QVY95010PRaIg9606 rogid:r/Cyj4UJk/cS8QdrbjhTZMPCigI9606 intact-crc:27E6D0D5B21DF7F8|rigid:btXzwXs83VnmPgYBYgUyjhq2K+w false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P11441 uniprotkb:Q6L8Q7 intact:EBI-356983|uniprotkb:Q5HY80|ensembl:ENSP00000358674 intact:EBI-2515865|ensembl:ENSP00000309142|uniprotkb:Q8IYU3|uniprotkb:Q8NDU2|uniprotkb:Q8TE78|uniprotkb:B4DTU8 psi-mi:ubl4a_human(display_long)|uniprotkb:UBL4A(gene name)|psi-mi:UBL4A(display_short)|uniprotkb:GDX(gene name synonym)|uniprotkb:DXS254E(gene name synonym)|uniprotkb:UBL4(gene name synonym)|uniprotkb:Ubiquitin-like protein GDX(gene name synonym) psi-mi:pde12_human(display_long)|uniprotkb:PDE12(gene name)|psi-mi:PDE12(display_short)|uniprotkb:Mitochondrial deadenylase(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515855|imex:IM-12079-50 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055050.1|ensembl:ENSG00000102178(gene)|ensembl:ENST00000369660(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0016020"(membrane)|go:"GO:0019787"(ubiquitin-like protein transferase activity)|go:"GO:0051087"(chaperone binding)|go:"GO:0071816"(tail-anchored membrane protein insertion into ER membrane)|go:"GO:0071818"(BAT3 complex)|interpro:IPR000626(Ubiquitin)|interpro:IPR019954|interpro:IPR019956|interpro:IPR029071|interpro:IPR041421|interpro:IPR044724|mint:P11441|rcsb pdb:2DZI|rcsb pdb:4WWR|rcsb pdb:4X86|reactome:R-HSA-9609523 ensembl:ENST00000311180(transcript)|go:"GO:0000175"(3'-5'-exoribonuclease activity)|go:"GO:0000288"(nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|go:"GO:0000958"(mitochondrial mRNA catabolic process)|go:"GO:0004527"(exonuclease activity)|go:"GO:0004535"("poly(A)-specific ribonuclease activity")|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006397"(mRNA processing)|go:"GO:0034611"(oligoribonucleotidase activity)|go:"GO:0035457"(cellular response to interferon-alpha)|go:"GO:0044528"(regulation of mitochondrial mRNA stability)|go:"GO:0045070"(positive regulation of viral genome replication)|go:"GO:0046872"(metal ion binding)|go:"GO:0051607"(defense response to virus)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071359"(cellular response to dsRNA)|go:"GO:0090305"(nucleic acid phosphodiester bond hydrolysis)|go:"GO:0090324"(negative regulation of oxidative phosphorylation)|go:"GO:0090503"(RNA phosphodiester bond hydrolysis, exonucleolytic)|ensembl:ENSG00000174840(gene)|interpro:IPR036691|mint:Q6L8Q7|rcsb pdb:4Z0V|rcsb pdb:4Z2B|rcsb pdb:4ZKF|reactome:R-HSA-8983711|interpro:IPR005135(Endonuclease/exonuclease/phosphatase)|refseq:NP_808881.3 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:euKOrDRC1mx0s2QVY95010PRaIg9606 rogid:P2ALFhSP4Qnqnd08vmkOcVoXe/I9606 intact-crc:27E6D0D5B21DF7F8|rigid:btXzwXs83VnmPgYBYgUyjhq2K+w false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P11441 uniprotkb:P46379 intact:EBI-356983|uniprotkb:Q5HY80|ensembl:ENSP00000358674 intact:EBI-347552|uniprotkb:A2ADJ7|uniprotkb:A3KQ42|uniprotkb:A3KQ44|uniprotkb:A6NGY6|uniprotkb:A6PWF7|uniprotkb:O95874|uniprotkb:Q5HYL9|uniprotkb:Q5SQ35|uniprotkb:Q5SQ36|uniprotkb:Q5SQ37|uniprotkb:Q5SQ41|uniprotkb:Q5SRP8|uniprotkb:Q5SRP9|uniprotkb:Q5STC1|uniprotkb:Q5STX1|uniprotkb:Q5STX3|uniprotkb:Q96SA6|uniprotkb:Q9BCN4|uniprotkb:B0UX84|uniprotkb:B4DZ12|uniprotkb:B4E3V4|uniprotkb:E7EMZ4|uniprotkb:F8VXY4|ensembl:ENSP00000354368|ensembl:ENSP00000390966|ensembl:ENSP00000397894 psi-mi:ubl4a_human(display_long)|uniprotkb:UBL4A(gene name)|psi-mi:UBL4A(display_short)|uniprotkb:GDX(gene name synonym)|uniprotkb:DXS254E(gene name synonym)|uniprotkb:UBL4(gene name synonym)|uniprotkb:Ubiquitin-like protein GDX(gene name synonym) psi-mi:bag6_human(display_long)|uniprotkb:BAT3(gene name synonym)|uniprotkb:G3(gene name synonym)|uniprotkb:HLA-B-associated transcript 3(gene name synonym)|uniprotkb:Protein G3(gene name synonym)|uniprotkb:BCL2-associated athanogene 6(gene name synonym)|uniprotkb:BAG6(gene name)|psi-mi:BAG6(display_short)|uniprotkb:BAG family molecular chaperone regulator 6(gene name synonym)|uniprotkb:Protein Scythe(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515855|imex:IM-12079-50 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055050.1|ensembl:ENSG00000102178(gene)|ensembl:ENST00000369660(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0016020"(membrane)|go:"GO:0019787"(ubiquitin-like protein transferase activity)|go:"GO:0051087"(chaperone binding)|go:"GO:0071816"(tail-anchored membrane protein insertion into ER membrane)|go:"GO:0071818"(BAT3 complex)|interpro:IPR000626(Ubiquitin)|interpro:IPR019954|interpro:IPR019956|interpro:IPR029071|interpro:IPR041421|interpro:IPR044724|mint:P11441|rcsb pdb:2DZI|rcsb pdb:4WWR|rcsb pdb:4X86|reactome:R-HSA-9609523 dip:DIP-31191N|refseq:NP_001092004.1|refseq:NP_001186627.1|refseq:NP_004630.3|refseq:NP_542433.1|refseq:NP_542434.1|refseq:NP_001186626.1|refseq:XP_016866776.1|ensembl:ENSG00000096155(gene)|ensembl:ENSG00000229524(gene)|ensembl:ENSG00000233348(gene)|ensembl:ENST00000361076(transcript)|ensembl:ENST00000449450(transcript)|ensembl:ENST00000451932(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0002429"(immune response-activating cell surface receptor signaling pathway)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007130"(synaptonemal complex assembly)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0016020"(membrane)|go:"GO:0018393"(internal peptidyl-lysine acetylation)|go:"GO:0030101"(natural killer cell activation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030324"(lung development)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0043022"(ribosome binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0050821"(protein stabilization)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0061857"(endoplasmic reticulum stress-induced pre-emptive quality control)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070628"(proteasome binding)|go:"GO:0071712"(ER-associated misfolded protein catabolic process)|go:"GO:0071816"(tail-anchored membrane protein insertion into ER membrane)|go:"GO:0071818"(BAT3 complex)|go:"GO:1904294"(positive regulation of ERAD pathway)|go:"GO:1904378"(maintenance of unfolded protein involved in ERAD pathway)|go:"GO:1904379"(protein localization to cytosolic proteasome complex involved in ERAD pathway)|go:"GO:1990381"(ubiquitin-specific protease binding)|interpro:IPR000626(Ubiquitin)|interpro:IPR019954|interpro:IPR021925|interpro:IPR029071|mint:P46379|rcsb pdb:1WX9|rcsb pdb:2N9P|rcsb pdb:4DWF|rcsb pdb:4EEW|rcsb pdb:4WWR|rcsb pdb:6AU8|reactome:R-HSA-9609523|rcsb pdb:4X86 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:euKOrDRC1mx0s2QVY95010PRaIg9606 rogid:ghHlLBbS3yeP2mN6AOoHs+CECKU9606 intact-crc:27E6D0D5B21DF7F8|rigid:btXzwXs83VnmPgYBYgUyjhq2K+w false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P11441 uniprotkb:O43681 intact:EBI-356983|uniprotkb:Q5HY80|ensembl:ENSP00000358674 intact:EBI-2515857|ensembl:ENSP00000349887|ensembl:ENSP00000466379|uniprotkb:Q53FC6|uniprotkb:A8K740|uniprotkb:A6NHP8|uniprotkb:Q92849|intact:EBI-2818109 psi-mi:ubl4a_human(display_long)|uniprotkb:UBL4A(gene name)|psi-mi:UBL4A(display_short)|uniprotkb:GDX(gene name synonym)|uniprotkb:DXS254E(gene name synonym)|uniprotkb:UBL4(gene name synonym)|uniprotkb:Ubiquitin-like protein GDX(gene name synonym) psi-mi:get3_human(display_long)|uniprotkb:GET3(gene name)|psi-mi:GET3(display_short)|uniprotkb:ARSA(gene name synonym)|uniprotkb:ASNA1(gene name synonym)|uniprotkb:Arsenical pump-driving ATPase(gene name synonym)|uniprotkb:Arsenite-stimulated ATPase(gene name synonym)|uniprotkb:Guided entry of tail-anchored proteins factor 3, ATPase(gene name synonym)|uniprotkb:TRC40(gene name synonym)|uniprotkb:Transmembrane domain recognition complex 40 kDa ATPase subunit(gene name synonym)|uniprotkb:hARSA-I(gene name synonym)|uniprotkb:hASNA-I(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515855|imex:IM-12079-50 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055050.1|ensembl:ENSG00000102178(gene)|ensembl:ENST00000369660(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0016020"(membrane)|go:"GO:0019787"(ubiquitin-like protein transferase activity)|go:"GO:0051087"(chaperone binding)|go:"GO:0071816"(tail-anchored membrane protein insertion into ER membrane)|go:"GO:0071818"(BAT3 complex)|interpro:IPR000626(Ubiquitin)|interpro:IPR019954|interpro:IPR019956|interpro:IPR029071|interpro:IPR041421|interpro:IPR044724|mint:P11441|rcsb pdb:2DZI|rcsb pdb:4WWR|rcsb pdb:4X86|reactome:R-HSA-9609523 ensembl:ENSG00000198356(gene)|ensembl:ENST00000357332(transcript)|ensembl:ENST00000591090(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006620"(posttranslational protein targeting to endoplasmic reticulum membrane)|go:"GO:0015105"(arsenite transmembrane transporter activity)|go:"GO:0016787"(hydrolase activity)|go:"GO:0043529"(GET complex)|go:"GO:0046872"(metal ion binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071816"(tail-anchored membrane protein insertion into ER membrane)|interpro:IPR016300(Arsenite-transporting ATPase)|interpro:IPR025723|interpro:IPR027417|interpro:IPR027542|mint:O43681|rcsb pdb:6SO5|reactome:R-HSA-9609523|refseq:NP_004308.2 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:euKOrDRC1mx0s2QVY95010PRaIg9606 rogid:j2jKZb3MH8Bd3hnoQhDO6bjbyxI9606 intact-crc:27E6D0D5B21DF7F8|rigid:btXzwXs83VnmPgYBYgUyjhq2K+w false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P11441 uniprotkb:F6VEM6 intact:EBI-356983|uniprotkb:Q5HY80|ensembl:ENSP00000358674 intact:EBI-2515873|ensembl:ENSP00000389355|ensembl:ENSP00000390226|ensembl:ENSP00000402585|ensembl:ENSP00000403277|ensembl:ENSP00000406914|ensembl:ENSP00000411043|ensembl:ENSP00000414702 psi-mi:ubl4a_human(display_long)|uniprotkb:UBL4A(gene name)|psi-mi:UBL4A(display_short)|uniprotkb:GDX(gene name synonym)|uniprotkb:DXS254E(gene name synonym)|uniprotkb:UBL4(gene name synonym)|uniprotkb:Ubiquitin-like protein GDX(gene name synonym) psi-mi:f6vem6_human(display_long)|uniprotkb:BAG6(gene name)|psi-mi:BAG6(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515855|imex:IM-12079-50 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055050.1|ensembl:ENSG00000102178(gene)|ensembl:ENST00000369660(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0016020"(membrane)|go:"GO:0019787"(ubiquitin-like protein transferase activity)|go:"GO:0051087"(chaperone binding)|go:"GO:0071816"(tail-anchored membrane protein insertion into ER membrane)|go:"GO:0071818"(BAT3 complex)|interpro:IPR000626(Ubiquitin)|interpro:IPR019954|interpro:IPR019956|interpro:IPR029071|interpro:IPR041421|interpro:IPR044724|mint:P11441|rcsb pdb:2DZI|rcsb pdb:4WWR|rcsb pdb:4X86|reactome:R-HSA-9609523 ensembl:ENSG00000096155(gene)|ensembl:ENSG00000204463(gene)|ensembl:ENSG00000227761(gene)|ensembl:ENSG00000228760(gene)|ensembl:ENSG00000229524(gene)|ensembl:ENSG00000233348(gene)|ensembl:ENSG00000234651(gene)|ensembl:ENST00000420942(transcript)|ensembl:ENST00000424480(transcript)|ensembl:ENST00000436434(transcript)|ensembl:ENST00000436807(transcript)|ensembl:ENST00000441994(transcript)|ensembl:ENST00000452627(transcript)|ensembl:ENST00000458287(transcript)|interpro:IPR000626(Ubiquitin)|interpro:IPR019954|interpro:IPR029071|uniprotkb:B1B0J4(uniprot-removed-ac) psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:euKOrDRC1mx0s2QVY95010PRaIg9606 rogid:72zceXeVV0wO+du0ylPqF3mAyGE9606 intact-crc:27E6D0D5B21DF7F8|rigid:btXzwXs83VnmPgYBYgUyjhq2K+w false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P11441 uniprotkb:Q92890 intact:EBI-356983|uniprotkb:Q5HY80|ensembl:ENSP00000358674 intact:EBI-1994090|uniprotkb:Q9Y5N0|uniprotkb:A8MW31|ensembl:ENSP00000263202 psi-mi:ubl4a_human(display_long)|uniprotkb:UBL4A(gene name)|psi-mi:UBL4A(display_short)|uniprotkb:GDX(gene name synonym)|uniprotkb:DXS254E(gene name synonym)|uniprotkb:UBL4(gene name synonym)|uniprotkb:Ubiquitin-like protein GDX(gene name synonym) psi-mi:ufd1_human(display_long)|uniprotkb:UFD1(gene name)|psi-mi:UFD1(display_short)|uniprotkb:UFD1L(gene name synonym)|uniprotkb:Ubiquitin fusion degradation protein 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515855|imex:IM-12079-50 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055050.1|ensembl:ENSG00000102178(gene)|ensembl:ENST00000369660(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0016020"(membrane)|go:"GO:0019787"(ubiquitin-like protein transferase activity)|go:"GO:0051087"(chaperone binding)|go:"GO:0071816"(tail-anchored membrane protein insertion into ER membrane)|go:"GO:0071818"(BAT3 complex)|interpro:IPR000626(Ubiquitin)|interpro:IPR019954|interpro:IPR019956|interpro:IPR029071|interpro:IPR041421|interpro:IPR044724|mint:P11441|rcsb pdb:2DZI|rcsb pdb:4WWR|rcsb pdb:4X86|reactome:R-HSA-9609523 refseq:NP_005650.2|refseq:NP_001030324.2|dip:DIP-45954N|ensembl:ENSG00000070010(gene)|ensembl:ENST00000263202(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0032480"(negative regulation of type I interferon production)|go:"GO:0034098"(VCP-NPL4-UFD1 AAA ATPase complex)|go:"GO:0036435"(K48-linked polyubiquitin modification-dependent protein binding)|go:"GO:0036501"(UFD1-NPL4 complex)|go:"GO:0039536"(negative regulation of RIG-I signaling pathway)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0071712"(ER-associated misfolded protein catabolic process)|interpro:IPR004854(Ubiquitin fusion degradation protein UFD1)|interpro:IPR042299|mint:Q92890|rcsb pdb:2YUJ|rcsb pdb:5B6C|rcsb pdb:5C1B|reactome:R-HSA-110320|reactome:R-HSA-5689880|go:"GO:0031593"(polyubiquitin modification-dependent protein binding) psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:euKOrDRC1mx0s2QVY95010PRaIg9606 rogid:TD7xj2n1cP5JexKMoVg1JfTQArI9606 intact-crc:27E6D0D5B21DF7F8|rigid:btXzwXs83VnmPgYBYgUyjhq2K+w false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P11441 uniprotkb:Q96CS3 intact:EBI-356983|uniprotkb:Q5HY80|ensembl:ENSP00000358674 intact:EBI-1055805|uniprotkb:O94963|uniprotkb:Q8IUF2|uniprotkb:Q9BRP2|uniprotkb:Q9BVM7|ensembl:ENSP00000261942 psi-mi:ubl4a_human(display_long)|uniprotkb:UBL4A(gene name)|psi-mi:UBL4A(display_short)|uniprotkb:GDX(gene name synonym)|uniprotkb:DXS254E(gene name synonym)|uniprotkb:UBL4(gene name synonym)|uniprotkb:Ubiquitin-like protein GDX(gene name synonym) psi-mi:faf2_human(display_long)|uniprotkb:Protein ETEA(gene name synonym)|uniprotkb:FAF2(gene name)|psi-mi:FAF2(display_short)|uniprotkb:ETEA(gene name synonym)|uniprotkb:KIAA0887(gene name synonym)|uniprotkb:UBXD8(gene name synonym)|uniprotkb:UBXN3B(gene name synonym)|uniprotkb:UBX domain-containing protein 3B(gene name synonym)|uniprotkb:UBX domain-containing protein 8(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515855|imex:IM-12079-50 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055050.1|ensembl:ENSG00000102178(gene)|ensembl:ENST00000369660(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0016020"(membrane)|go:"GO:0019787"(ubiquitin-like protein transferase activity)|go:"GO:0051087"(chaperone binding)|go:"GO:0071816"(tail-anchored membrane protein insertion into ER membrane)|go:"GO:0071818"(BAT3 complex)|interpro:IPR000626(Ubiquitin)|interpro:IPR019954|interpro:IPR019956|interpro:IPR029071|interpro:IPR041421|interpro:IPR044724|mint:P11441|rcsb pdb:2DZI|rcsb pdb:4WWR|rcsb pdb:4X86|reactome:R-HSA-9609523 refseq:NP_055428.1|ensembl:ENSP00000261942|ensembl:ENST00000261942(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005811"(lipid droplet)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034098"(VCP-NPL4-UFD1 AAA ATPase complex)|go:"GO:0034389"(lipid droplet organization)|go:"GO:0035473"(lipase binding)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0055102"(lipase inhibitor activity)|interpro:IPR001012(UBX)|interpro:IPR006577(UAS)|interpro:IPR009060(UBA-like)|interpro:IPR029071|interpro:IPR036249|mint:Q96CS3|rcsb pdb:2DAM|reactome:R-HSA-6798695|reactome:R-HSA-8980692|ensembl:ENSG00000113194(gene)|dip:DIP-46261N psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:euKOrDRC1mx0s2QVY95010PRaIg9606 rogid:GCm7BqDpwxDW1iABu0cShmWHtZQ9606 intact-crc:27E6D0D5B21DF7F8|rigid:btXzwXs83VnmPgYBYgUyjhq2K+w false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P11441 uniprotkb:Q8TBZ3 intact:EBI-356983|uniprotkb:Q5HY80|ensembl:ENSP00000358674 intact:EBI-2511486|ensembl:ENSP00000341037|uniprotkb:Q8WXX2|uniprotkb:Q9UF86|uniprotkb:Q8NCN7|intact:EBI-11109494|uniprotkb:H0YJJ1|uniprotkb:Q86TU2|uniprotkb:B4DN18|uniprotkb:E7EUY8|uniprotkb:F8W9S4|uniprotkb:G3V2F8|uniprotkb:G3V5R0 psi-mi:ubl4a_human(display_long)|uniprotkb:UBL4A(gene name)|psi-mi:UBL4A(display_short)|uniprotkb:GDX(gene name synonym)|uniprotkb:DXS254E(gene name synonym)|uniprotkb:UBL4(gene name synonym)|uniprotkb:Ubiquitin-like protein GDX(gene name synonym) psi-mi:wdr20_human(display_long)|uniprotkb:WDR20(gene name)|psi-mi:WDR20(display_short)|uniprotkb:Protein DMR(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515855|imex:IM-12079-50 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055050.1|ensembl:ENSG00000102178(gene)|ensembl:ENST00000369660(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0016020"(membrane)|go:"GO:0019787"(ubiquitin-like protein transferase activity)|go:"GO:0051087"(chaperone binding)|go:"GO:0071816"(tail-anchored membrane protein insertion into ER membrane)|go:"GO:0071818"(BAT3 complex)|interpro:IPR000626(Ubiquitin)|interpro:IPR019954|interpro:IPR019956|interpro:IPR029071|interpro:IPR041421|interpro:IPR044724|mint:P11441|rcsb pdb:2DZI|rcsb pdb:4WWR|rcsb pdb:4X86|reactome:R-HSA-9609523 ensembl:ENSG00000140153(gene)|ensembl:ENST00000342702(transcript)|go:"GO:0005654"(nucleoplasm)|interpro:IPR001680(WD40 repeat)|interpro:IPR036322|mint:Q8TBZ3|rcsb pdb:5K19|rcsb pdb:5K1C|rcsb pdb:6JLQ|reactome:R-HSA-5689880|refseq:NP_001229343.1|refseq:NP_001229345.1|refseq:NP_001229346.1|refseq:NP_001229347.1|refseq:NP_653175.2|refseq:NP_851808.1|refseq:NP_851825.1|refseq:NP_001229344.1 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:euKOrDRC1mx0s2QVY95010PRaIg9606 rogid:2MfZps9YU8xQbWazkq2sIqXjHHg9606 intact-crc:27E6D0D5B21DF7F8|rigid:btXzwXs83VnmPgYBYgUyjhq2K+w false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P11441 uniprotkb:Q8TAT6 intact:EBI-356983|uniprotkb:Q5HY80|ensembl:ENSP00000358674 intact:EBI-1994109|uniprotkb:Q8N3J1|uniprotkb:Q9H8V2|uniprotkb:Q9H964|uniprotkb:Q9NWR5|uniprotkb:Q9P229|ensembl:ENSP00000331487 psi-mi:ubl4a_human(display_long)|uniprotkb:UBL4A(gene name)|psi-mi:UBL4A(display_short)|uniprotkb:GDX(gene name synonym)|uniprotkb:DXS254E(gene name synonym)|uniprotkb:UBL4(gene name synonym)|uniprotkb:Ubiquitin-like protein GDX(gene name synonym) psi-mi:npl4_human(display_long)|uniprotkb:NPLOC4(gene name)|psi-mi:NPLOC4(display_short)|uniprotkb:KIAA1499(gene name synonym)|uniprotkb:NPL4(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515855|imex:IM-12079-50 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055050.1|ensembl:ENSG00000102178(gene)|ensembl:ENST00000369660(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0016020"(membrane)|go:"GO:0019787"(ubiquitin-like protein transferase activity)|go:"GO:0051087"(chaperone binding)|go:"GO:0071816"(tail-anchored membrane protein insertion into ER membrane)|go:"GO:0071818"(BAT3 complex)|interpro:IPR000626(Ubiquitin)|interpro:IPR019954|interpro:IPR019956|interpro:IPR029071|interpro:IPR041421|interpro:IPR044724|mint:P11441|rcsb pdb:2DZI|rcsb pdb:4WWR|rcsb pdb:4X86|reactome:R-HSA-9609523 refseq:XP_011523281.1|refseq:NP_060391.2|dip:DIP-44059N|ensembl:ENSG00000182446(gene)|ensembl:ENST00000331134(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007030"(Golgi organization)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032480"(negative regulation of type I interferon production)|go:"GO:0034098"(VCP-NPL4-UFD1 AAA ATPase complex)|go:"GO:0036501"(UFD1-NPL4 complex)|go:"GO:0039536"(negative regulation of RIG-I signaling pathway)|go:"GO:0042175"(nuclear outer membrane-endoplasmic reticulum membrane network)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR007716(NPL4, zinc-binding putative)|interpro:IPR007717(NPL4)|interpro:IPR016563(Polyubiquitin-tagged protein recognition complex, Npl4 component)|interpro:IPR024682|interpro:IPR029071|interpro:IPR036443|interpro:IPR037518|mint:Q8TAT6|reactome:R-HSA-110320 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:euKOrDRC1mx0s2QVY95010PRaIg9606 rogid:GXRNmG7yqEf5aFMo7yPDih93yfk9606 intact-crc:27E6D0D5B21DF7F8|rigid:btXzwXs83VnmPgYBYgUyjhq2K+w false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification) uniprotkb:P11441 uniprotkb:Q7L5D6 intact:EBI-356983|uniprotkb:Q5HY80|ensembl:ENSP00000358674 intact:EBI-711823|uniprotkb:A4D2Q1|uniprotkb:B3KNC7|uniprotkb:Q9UFC9|uniprotkb:Q9Y309|ensembl:ENSP00000265857 psi-mi:ubl4a_human(display_long)|uniprotkb:UBL4A(gene name)|psi-mi:UBL4A(display_short)|uniprotkb:GDX(gene name synonym)|uniprotkb:DXS254E(gene name synonym)|uniprotkb:UBL4(gene name synonym)|uniprotkb:Ubiquitin-like protein GDX(gene name synonym) psi-mi:get4_human(display_long)|uniprotkb:CEE(gene name synonym)|uniprotkb:Conserved edge-expressed protein(gene name synonym)|uniprotkb:GET4(gene name)|psi-mi:GET4(display_short)|uniprotkb:CGI-20(orf name)|uniprotkb:C7orf20(gene name synonym)|uniprotkb:TRC35(gene name synonym)|uniprotkb:Transmembrane domain recognition complex 35 kDa subunit(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Sowa et al. (2009) imex:IM-12079|pubmed:19615732 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2515855|imex:IM-12079-50 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_055050.1|ensembl:ENSG00000102178(gene)|ensembl:ENST00000369660(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0016020"(membrane)|go:"GO:0019787"(ubiquitin-like protein transferase activity)|go:"GO:0051087"(chaperone binding)|go:"GO:0071816"(tail-anchored membrane protein insertion into ER membrane)|go:"GO:0071818"(BAT3 complex)|interpro:IPR000626(Ubiquitin)|interpro:IPR019954|interpro:IPR019956|interpro:IPR029071|interpro:IPR041421|interpro:IPR044724|mint:P11441|rcsb pdb:2DZI|rcsb pdb:4WWR|rcsb pdb:4X86|reactome:R-HSA-9609523 ensembl:ENSG00000239857(gene)|ensembl:ENST00000265857(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0045048"(protein insertion into ER membrane)|go:"GO:0051087"(chaperone binding)|go:"GO:0051220"(cytoplasmic sequestering of protein)|go:"GO:0071816"(tail-anchored membrane protein insertion into ER membrane)|go:"GO:0071818"(BAT3 complex)|go:"GO:1904378"(maintenance of unfolded protein involved in ERAD pathway)|interpro:IPR007317(Protein of unknown function DUF410)|interpro:IPR011990(Tetratricopeptide-like helical)|mint:Q7L5D6|rcsb pdb:6AU8|reactome:R-HSA-9609523|refseq:NP_057033.2 psi-mi:"MI:0469"(intact) - - figure legend:submitted by author|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen) - 2009/12/18 2014/10/16 rogid:euKOrDRC1mx0s2QVY95010PRaIg9606 rogid:WbZJTGrC2/fB4iOFLJYn9MIWZFA9606 intact-crc:27E6D0D5B21DF7F8|rigid:btXzwXs83VnmPgYBYgUyjhq2K+w false ha tag:n-n|flag tag:n-n - - - psi-mi:"MI:0102"(sequence tag identification) psi-mi:"MI:0102"(sequence tag identification)