#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q7YTZ1	uniprotkb:Q9VN41	intact:EBI-870194|uniprotkb:B7Z0D2|ensemblmetazoa:FBpp0288968	intact:EBI-186581|uniprotkb:Q058Y9|ensemblmetazoa:FBpp0290511	psi-mi:q7ytz1_drome(display_long)|uniprotkb:mus312(gene name)|psi-mi:mus312(display_short)|uniprotkb:mus312-RD(gene name synonym)|uniprotkb:Dmel_CG8601(orf name)|uniprotkb:Dmel\CG8601(gene name synonym)|uniprotkb:MUS312(gene name synonym)|uniprotkb:"mus(3)312"(gene name synonym)|uniprotkb:CG8601(orf name)	psi-mi:slx1_drome(display_long)|uniprotkb:CG18271(orf name)|uniprotkb:slx1(gene name)|psi-mi:slx1(display_short)	psi-mi:"MI:0018"(two hybrid)	Fekairi et al. (2009)	imex:IM-12201|pubmed:19596236	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	taxid:7227(drome)|taxid:7227("Drosophila melanogaster (Fruit fly)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2407906|imex:IM-12201-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	flybase:FBgn0002909|refseq:NP_001137902.1|ensemblmetazoa:FBgn0002909(gene)|ensemblmetazoa:FBtr0299690(transcript)	refseq:NP_649484.3|flybase:FBgn0037263|ensemblmetazoa:FBgn0037263(gene)|ensemblmetazoa:FBtr0301296(transcript)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0004520"(endodeoxyribonuclease activity)|go:"GO:0008821"(crossover junction endodeoxyribonuclease activity)|go:"GO:0017108"(5'-flap endonuclease activity)|go:"GO:0033557"(Slx1-Slx4 complex)|go:"GO:0046872"(metal ion binding)|interpro:IPR000305(Excinuclease ABC, C subunit, N-terminal)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR026850|interpro:IPR027520|interpro:IPR035901|reactome:R-DME-5693568	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2009/08/04	2014/10/16	rogid:Px5fSPN5YzmK2jGCbs90ytOYOZQ7227	rogid:uL5oV5TWys5torll6MvTqyZC1r07227	intact-crc:F64683E1B4FD6287|rigid:Xky5JCuC+NjZ149nJRYZS3rvVmc	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8IY92	uniprotkb:Q9BQ83	intact:EBI-2370740|uniprotkb:Q69YT8|uniprotkb:Q8TF15|uniprotkb:Q96JP1|intact:EBI-2560942|ensembl:ENSP00000294008	intact:EBI-2370858|uniprotkb:Q6NTG6|uniprotkb:B7ZME1|ensembl:ENSP00000251303|ensembl:ENSP00000328940	psi-mi:slx4_human(display_long)|uniprotkb:SLX4(gene name)|psi-mi:SLX4(display_short)|uniprotkb:BTB/POZ domain-containing protein 12(gene name synonym)|uniprotkb:BTBD12(gene name synonym)|uniprotkb:KIAA1784(gene name synonym)|uniprotkb:KIAA1987(gene name synonym)	psi-mi:slx1_human(display_long)|uniprotkb:GIYD1(gene name synonym)|uniprotkb:GIYD2(gene name synonym)|uniprotkb:SLX1(gene name synonym)|uniprotkb:GIY-YIG domain-containing protein 1(gene name synonym)|uniprotkb:SLX1A(gene name)|psi-mi:SLX1A(display_short)|uniprotkb:SLX1B(gene name)|psi-mi:SLX1B(display_short)	psi-mi:"MI:0018"(two hybrid)	Fekairi et al. (2009)	imex:IM-12201|pubmed:19596236	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2407951|imex:IM-12201-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_115820.2|ensembl:ENSG00000188827(gene)|ensembl:ENST00000294008(transcript)|go:"GO:0000706"(meiotic DNA double-strand break processing)|go:"GO:0000712"(resolution of meiotic recombination intermediates)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003677"(DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0010792"(DNA double-strand break processing involved in repair via single-strand annealing)|go:"GO:0019899"(enzyme binding)|go:"GO:0030054"(cell junction)|go:"GO:0033557"(Slx1-Slx4 complex)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0046872"(metal ion binding)|go:"GO:0061820"(telomeric D-loop disassembly)|go:"GO:0072429"(response to intra-S DNA damage checkpoint signaling)|go:"GO:0090656"(t-circle formation)|go:"GO:1904357"(negative regulation of telomere maintenance via telomere lengthening)|go:"GO:1904431"(positive regulation of t-circle formation)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006642(Zinc finger, Rad18-type putative)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR018574|rcsb pdb:4M7C|rcsb pdb:4UYI|rcsb pdb:4ZOU|rcsb pdb:7BU5|reactome:R-HSA-5693568|reactome:R-HSA-6783310	refseq:NP_001014999.1|refseq:NP_001015000.1|refseq:NP_076949.1|refseq:NP_835145.1|ensembl:ENSG00000132207(gene)|ensembl:ENSG00000181625(gene)|ensembl:ENST00000251303(transcript)|ensembl:ENST00000330181(transcript)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0008821"(crossover junction endodeoxyribonuclease activity)|go:"GO:0010792"(DNA double-strand break processing involved in repair via single-strand annealing)|go:"GO:0010833"(telomere maintenance via telomere lengthening)|go:"GO:0017108"(5'-flap endonuclease activity)|go:"GO:0033557"(Slx1-Slx4 complex)|go:"GO:0046872"(metal ion binding)|go:"GO:0061820"(telomeric D-loop disassembly)|go:"GO:0090656"(t-circle formation)|go:"GO:1904357"(negative regulation of telomere maintenance via telomere lengthening)|go:"GO:1904431"(positive regulation of t-circle formation)|interpro:IPR000305(Excinuclease ABC, C subunit, N-terminal)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR027520|interpro:IPR035901|reactome:R-HSA-5693568|reactome:R-HSA-6783310	psi-mi:"MI:0469"(intact)	-	-	figure legend:Figs. 2A, 2B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2009/08/04	2014/10/16	rogid:NuJHCWXHD3dfQNmsNz/LVD0UHsQ9606	rogid:HOCvski3UnUW86f0rfOUf8fTQ8c9606	intact-crc:0E1D5237A1C2EB60|rigid:hOZuSPz4cE3VihVBCQuxn8bTJWM	false	sufficient binding region:1664-1834	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8IY92	uniprotkb:Q92889	intact:EBI-2370740|uniprotkb:Q69YT8|uniprotkb:Q8TF15|uniprotkb:Q96JP1|intact:EBI-2560942|ensembl:ENSP00000294008	intact:EBI-2370770|uniprotkb:O00140|uniprotkb:Q8TD83|uniprotkb:A5PKV6|uniprotkb:A8K111|ensembl:ENSP00000310520	psi-mi:slx4_human(display_long)|uniprotkb:SLX4(gene name)|psi-mi:SLX4(display_short)|uniprotkb:BTB/POZ domain-containing protein 12(gene name synonym)|uniprotkb:BTBD12(gene name synonym)|uniprotkb:KIAA1784(gene name synonym)|uniprotkb:KIAA1987(gene name synonym)	psi-mi:xpf_human(display_long)|uniprotkb:ERCC4(gene name)|psi-mi:ERCC4(display_short)|uniprotkb:ERCC11(gene name synonym)|uniprotkb:XPF(gene name synonym)|uniprotkb:DNA excision repair protein ERCC-4(gene name synonym)|uniprotkb:DNA repair protein complementing XP-F cells(gene name synonym)|uniprotkb:Xeroderma pigmentosum group F-complementing protein(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Fekairi et al. (2009)	imex:IM-12201|pubmed:19596236	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2408021|imex:IM-12201-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_115820.2|ensembl:ENSG00000188827(gene)|ensembl:ENST00000294008(transcript)|go:"GO:0000706"(meiotic DNA double-strand break processing)|go:"GO:0000712"(resolution of meiotic recombination intermediates)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003677"(DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0010792"(DNA double-strand break processing involved in repair via single-strand annealing)|go:"GO:0019899"(enzyme binding)|go:"GO:0030054"(cell junction)|go:"GO:0033557"(Slx1-Slx4 complex)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0046872"(metal ion binding)|go:"GO:0061820"(telomeric D-loop disassembly)|go:"GO:0072429"(response to intra-S DNA damage checkpoint signaling)|go:"GO:0090656"(t-circle formation)|go:"GO:1904357"(negative regulation of telomere maintenance via telomere lengthening)|go:"GO:1904431"(positive regulation of t-circle formation)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006642(Zinc finger, Rad18-type putative)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR018574|rcsb pdb:4M7C|rcsb pdb:4UYI|rcsb pdb:4ZOU|rcsb pdb:7BU5|reactome:R-HSA-5693568|reactome:R-HSA-6783310	refseq:NP_005227.1|dip:DIP-42006N|ensembl:ENSG00000175595(gene)|ensembl:ENST00000311895(transcript)|go:"GO:0000014"(single-stranded DNA endodeoxyribonuclease activity)|go:"GO:0000109"(nucleotide-excision repair complex)|go:"GO:0000110"(nucleotide-excision repair factor 1 complex)|go:"GO:0000712"(resolution of meiotic recombination intermediates)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001094"(TFIID-class transcription factor complex binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0004520"(endodeoxyribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006295"(nucleotide-excision repair, DNA incision, 3'-to lesion)|go:"GO:0006296"(nucleotide-excision repair, DNA incision, 5'-to lesion)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009411"(response to UV)|go:"GO:0009650"(UV protection)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0032205"(negative regulation of telomere maintenance)|go:"GO:0033683"(nucleotide-excision repair, DNA incision)|go:"GO:0034644"(cellular response to UV)|go:"GO:0042802"(identical protein binding)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0061819"(telomeric DNA-containing double minutes formation)|go:"GO:0070522"(ERCC4-ERCC1 complex)|go:"GO:1901255"(nucleotide-excision repair involved in interstrand cross-link repair)|go:"GO:1904357"(negative regulation of telomere maintenance via telomere lengthening)|go:"GO:1905765"(negative regulation of protection from non-homologous end joining at telomere)|go:"GO:1905768"(negative regulation of double-stranded telomeric DNA binding)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR006166(DNA repair nuclease, XPF-type/Helicase)|interpro:IPR006167(DNA repair protein)|interpro:IPR010994(RuvA domain 2-like)|interpro:IPR011335(Restriction endonuclease, type II-like, core)|mint:Q92889|rcsb pdb:1Z00|rcsb pdb:2A1J|rcsb pdb:2AQ0|rcsb pdb:2KN7|rcsb pdb:2MUT|rcsb pdb:6SXA|rcsb pdb:6SXB|reactome:R-HSA-5685938|reactome:R-HSA-5696395|reactome:R-HSA-5696400|reactome:R-HSA-6782135|reactome:R-HSA-6783310	psi-mi:"MI:0469"(intact)	-	-	figure legend:Figs. 2D, 2E|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2009/08/04	2014/10/16	rogid:NuJHCWXHD3dfQNmsNz/LVD0UHsQ9606	rogid:A42t082dZNQH72TF3QRa+Msuoms9606	intact-crc:408D515C568589DE|rigid:NVLCAegsfsACIG0hl/2n/lYDFOI	false	sufficient binding region:1-684	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q9BQ83	uniprotkb:Q92889	intact:EBI-2370858|uniprotkb:Q6NTG6|uniprotkb:B7ZME1|ensembl:ENSP00000251303|ensembl:ENSP00000328940	intact:EBI-2370770|uniprotkb:O00140|uniprotkb:Q8TD83|uniprotkb:A5PKV6|uniprotkb:A8K111|ensembl:ENSP00000310520	psi-mi:slx1_human(display_long)|uniprotkb:GIYD1(gene name synonym)|uniprotkb:GIYD2(gene name synonym)|uniprotkb:SLX1(gene name synonym)|uniprotkb:GIY-YIG domain-containing protein 1(gene name synonym)|uniprotkb:SLX1A(gene name)|psi-mi:SLX1A(display_short)|uniprotkb:SLX1B(gene name)|psi-mi:SLX1B(display_short)	psi-mi:xpf_human(display_long)|uniprotkb:ERCC4(gene name)|psi-mi:ERCC4(display_short)|uniprotkb:ERCC11(gene name synonym)|uniprotkb:XPF(gene name synonym)|uniprotkb:DNA excision repair protein ERCC-4(gene name synonym)|uniprotkb:DNA repair protein complementing XP-F cells(gene name synonym)|uniprotkb:Xeroderma pigmentosum group F-complementing protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Fekairi et al. (2009)	imex:IM-12201|pubmed:19596236	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2408002|imex:IM-12201-8	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001014999.1|refseq:NP_001015000.1|refseq:NP_076949.1|refseq:NP_835145.1|ensembl:ENSG00000132207(gene)|ensembl:ENSG00000181625(gene)|ensembl:ENST00000251303(transcript)|ensembl:ENST00000330181(transcript)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0008821"(crossover junction endodeoxyribonuclease activity)|go:"GO:0010792"(DNA double-strand break processing involved in repair via single-strand annealing)|go:"GO:0010833"(telomere maintenance via telomere lengthening)|go:"GO:0017108"(5'-flap endonuclease activity)|go:"GO:0033557"(Slx1-Slx4 complex)|go:"GO:0046872"(metal ion binding)|go:"GO:0061820"(telomeric D-loop disassembly)|go:"GO:0090656"(t-circle formation)|go:"GO:1904357"(negative regulation of telomere maintenance via telomere lengthening)|go:"GO:1904431"(positive regulation of t-circle formation)|interpro:IPR000305(Excinuclease ABC, C subunit, N-terminal)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR027520|interpro:IPR035901|reactome:R-HSA-5693568|reactome:R-HSA-6783310	refseq:NP_005227.1|dip:DIP-42006N|ensembl:ENSG00000175595(gene)|ensembl:ENST00000311895(transcript)|go:"GO:0000014"(single-stranded DNA endodeoxyribonuclease activity)|go:"GO:0000109"(nucleotide-excision repair complex)|go:"GO:0000110"(nucleotide-excision repair factor 1 complex)|go:"GO:0000712"(resolution of meiotic recombination intermediates)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001094"(TFIID-class transcription factor complex binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0004520"(endodeoxyribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006295"(nucleotide-excision repair, DNA incision, 3'-to lesion)|go:"GO:0006296"(nucleotide-excision repair, DNA incision, 5'-to lesion)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009411"(response to UV)|go:"GO:0009650"(UV protection)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0032205"(negative regulation of telomere maintenance)|go:"GO:0033683"(nucleotide-excision repair, DNA incision)|go:"GO:0034644"(cellular response to UV)|go:"GO:0042802"(identical protein binding)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0061819"(telomeric DNA-containing double minutes formation)|go:"GO:0070522"(ERCC4-ERCC1 complex)|go:"GO:1901255"(nucleotide-excision repair involved in interstrand cross-link repair)|go:"GO:1904357"(negative regulation of telomere maintenance via telomere lengthening)|go:"GO:1905765"(negative regulation of protection from non-homologous end joining at telomere)|go:"GO:1905768"(negative regulation of double-stranded telomeric DNA binding)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR006166(DNA repair nuclease, XPF-type/Helicase)|interpro:IPR006167(DNA repair protein)|interpro:IPR010994(RuvA domain 2-like)|interpro:IPR011335(Restriction endonuclease, type II-like, core)|mint:Q92889|rcsb pdb:1Z00|rcsb pdb:2A1J|rcsb pdb:2AQ0|rcsb pdb:2KN7|rcsb pdb:2MUT|rcsb pdb:6SXA|rcsb pdb:6SXB|reactome:R-HSA-5685938|reactome:R-HSA-5696395|reactome:R-HSA-5696400|reactome:R-HSA-6782135|reactome:R-HSA-6783310	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 2C, Supp. Fig. 4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2009/08/04	2014/10/16	rogid:HOCvski3UnUW86f0rfOUf8fTQ8c9606	rogid:A42t082dZNQH72TF3QRa+Msuoms9606	intact-crc:6D362685DFFDB821|rigid:Lne3s97Wqa+hl74hnpTLPRNK+9Y	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9BQ83	uniprotkb:Q8IY92	intact:EBI-2370858|uniprotkb:Q6NTG6|uniprotkb:B7ZME1|ensembl:ENSP00000251303|ensembl:ENSP00000328940	intact:EBI-2370740|uniprotkb:Q69YT8|uniprotkb:Q8TF15|uniprotkb:Q96JP1|intact:EBI-2560942|ensembl:ENSP00000294008	psi-mi:slx1_human(display_long)|uniprotkb:GIYD1(gene name synonym)|uniprotkb:GIYD2(gene name synonym)|uniprotkb:SLX1(gene name synonym)|uniprotkb:GIY-YIG domain-containing protein 1(gene name synonym)|uniprotkb:SLX1A(gene name)|psi-mi:SLX1A(display_short)|uniprotkb:SLX1B(gene name)|psi-mi:SLX1B(display_short)	psi-mi:slx4_human(display_long)|uniprotkb:SLX4(gene name)|psi-mi:SLX4(display_short)|uniprotkb:BTB/POZ domain-containing protein 12(gene name synonym)|uniprotkb:BTBD12(gene name synonym)|uniprotkb:KIAA1784(gene name synonym)|uniprotkb:KIAA1987(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Fekairi et al. (2009)	imex:IM-12201|pubmed:19596236	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2408002|imex:IM-12201-8	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001014999.1|refseq:NP_001015000.1|refseq:NP_076949.1|refseq:NP_835145.1|ensembl:ENSG00000132207(gene)|ensembl:ENSG00000181625(gene)|ensembl:ENST00000251303(transcript)|ensembl:ENST00000330181(transcript)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0008821"(crossover junction endodeoxyribonuclease activity)|go:"GO:0010792"(DNA double-strand break processing involved in repair via single-strand annealing)|go:"GO:0010833"(telomere maintenance via telomere lengthening)|go:"GO:0017108"(5'-flap endonuclease activity)|go:"GO:0033557"(Slx1-Slx4 complex)|go:"GO:0046872"(metal ion binding)|go:"GO:0061820"(telomeric D-loop disassembly)|go:"GO:0090656"(t-circle formation)|go:"GO:1904357"(negative regulation of telomere maintenance via telomere lengthening)|go:"GO:1904431"(positive regulation of t-circle formation)|interpro:IPR000305(Excinuclease ABC, C subunit, N-terminal)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR027520|interpro:IPR035901|reactome:R-HSA-5693568|reactome:R-HSA-6783310	refseq:NP_115820.2|ensembl:ENSG00000188827(gene)|ensembl:ENST00000294008(transcript)|go:"GO:0000706"(meiotic DNA double-strand break processing)|go:"GO:0000712"(resolution of meiotic recombination intermediates)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003677"(DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0010792"(DNA double-strand break processing involved in repair via single-strand annealing)|go:"GO:0019899"(enzyme binding)|go:"GO:0030054"(cell junction)|go:"GO:0033557"(Slx1-Slx4 complex)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0046872"(metal ion binding)|go:"GO:0061820"(telomeric D-loop disassembly)|go:"GO:0072429"(response to intra-S DNA damage checkpoint signaling)|go:"GO:0090656"(t-circle formation)|go:"GO:1904357"(negative regulation of telomere maintenance via telomere lengthening)|go:"GO:1904431"(positive regulation of t-circle formation)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006642(Zinc finger, Rad18-type putative)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR018574|rcsb pdb:4M7C|rcsb pdb:4UYI|rcsb pdb:4ZOU|rcsb pdb:7BU5|reactome:R-HSA-5693568|reactome:R-HSA-6783310	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 2C, Supp. Fig. 4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2009/08/04	2014/10/16	rogid:HOCvski3UnUW86f0rfOUf8fTQ8c9606	rogid:NuJHCWXHD3dfQNmsNz/LVD0UHsQ9606	intact-crc:6D362685DFFDB821|rigid:Lne3s97Wqa+hl74hnpTLPRNK+9Y	false	flag tag:?-?	sufficient binding region:684-1834|green fluorescent protein tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9BQ83	uniprotkb:Q96NY9	intact:EBI-2370858|uniprotkb:Q6NTG6|uniprotkb:B7ZME1|ensembl:ENSP00000251303|ensembl:ENSP00000328940	intact:EBI-2370806|uniprotkb:Q9H7D9|ensembl:ENSP00000307853	psi-mi:slx1_human(display_long)|uniprotkb:GIYD1(gene name synonym)|uniprotkb:GIYD2(gene name synonym)|uniprotkb:SLX1(gene name synonym)|uniprotkb:GIY-YIG domain-containing protein 1(gene name synonym)|uniprotkb:SLX1A(gene name)|psi-mi:SLX1A(display_short)|uniprotkb:SLX1B(gene name)|psi-mi:SLX1B(display_short)	psi-mi:mus81_human(display_long)|uniprotkb:MUS81(gene name)|psi-mi:MUS81(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Fekairi et al. (2009)	imex:IM-12201|pubmed:19596236	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2408044|imex:IM-12201-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001014999.1|refseq:NP_001015000.1|refseq:NP_076949.1|refseq:NP_835145.1|ensembl:ENSG00000132207(gene)|ensembl:ENSG00000181625(gene)|ensembl:ENST00000251303(transcript)|ensembl:ENST00000330181(transcript)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0008821"(crossover junction endodeoxyribonuclease activity)|go:"GO:0010792"(DNA double-strand break processing involved in repair via single-strand annealing)|go:"GO:0010833"(telomere maintenance via telomere lengthening)|go:"GO:0017108"(5'-flap endonuclease activity)|go:"GO:0033557"(Slx1-Slx4 complex)|go:"GO:0046872"(metal ion binding)|go:"GO:0061820"(telomeric D-loop disassembly)|go:"GO:0090656"(t-circle formation)|go:"GO:1904357"(negative regulation of telomere maintenance via telomere lengthening)|go:"GO:1904431"(positive regulation of t-circle formation)|interpro:IPR000305(Excinuclease ABC, C subunit, N-terminal)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR027520|interpro:IPR035901|reactome:R-HSA-5693568|reactome:R-HSA-6783310	refseq:XP_011543572.1|refseq:NP_079404.3|dip:DIP-48630N|ensembl:ENSG00000172732(gene)|ensembl:ENST00000308110(transcript)|go:"GO:0000712"(resolution of meiotic recombination intermediates)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0000737"(DNA catabolic process, endonucleolytic)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006281"(DNA repair)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0033687"(osteoblast proliferation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048257"(3'-flap endonuclease activity)|go:"GO:0048476"(Holliday junction resolvase complex)|go:"GO:0072429"(response to intra-S DNA damage checkpoint signaling)|interpro:IPR006166(DNA repair nuclease, XPF-type/Helicase)|interpro:IPR011335(Restriction endonuclease, type II-like, core)|interpro:IPR027421|interpro:IPR036388|interpro:IPR042530|rcsb pdb:2MC3|rcsb pdb:2ZIX|rcsb pdb:4P0P|rcsb pdb:4P0Q|rcsb pdb:4P0R|rcsb pdb:4P0S|rcsb pdb:6VWB|reactome:R-HSA-5693568|reactome:R-HSA-6783310	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 6B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2009/08/04	2014/10/16	rogid:HOCvski3UnUW86f0rfOUf8fTQ8c9606	rogid:FKXIIwLeq3tNM8rOASbXwGFW7PQ9606	intact-crc:16D44B7D24BBB88B|rigid:J3+98kZ14arGSPZEU/6OAAgIqik	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9BQ83	uniprotkb:Q8IY92	intact:EBI-2370858|uniprotkb:Q6NTG6|uniprotkb:B7ZME1|ensembl:ENSP00000251303|ensembl:ENSP00000328940	intact:EBI-2370740|uniprotkb:Q69YT8|uniprotkb:Q8TF15|uniprotkb:Q96JP1|intact:EBI-2560942|ensembl:ENSP00000294008	psi-mi:slx1_human(display_long)|uniprotkb:GIYD1(gene name synonym)|uniprotkb:GIYD2(gene name synonym)|uniprotkb:SLX1(gene name synonym)|uniprotkb:GIY-YIG domain-containing protein 1(gene name synonym)|uniprotkb:SLX1A(gene name)|psi-mi:SLX1A(display_short)|uniprotkb:SLX1B(gene name)|psi-mi:SLX1B(display_short)	psi-mi:slx4_human(display_long)|uniprotkb:SLX4(gene name)|psi-mi:SLX4(display_short)|uniprotkb:BTB/POZ domain-containing protein 12(gene name synonym)|uniprotkb:BTBD12(gene name synonym)|uniprotkb:KIAA1784(gene name synonym)|uniprotkb:KIAA1987(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Fekairi et al. (2009)	imex:IM-12201|pubmed:19596236	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2408044|imex:IM-12201-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001014999.1|refseq:NP_001015000.1|refseq:NP_076949.1|refseq:NP_835145.1|ensembl:ENSG00000132207(gene)|ensembl:ENSG00000181625(gene)|ensembl:ENST00000251303(transcript)|ensembl:ENST00000330181(transcript)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0008821"(crossover junction endodeoxyribonuclease activity)|go:"GO:0010792"(DNA double-strand break processing involved in repair via single-strand annealing)|go:"GO:0010833"(telomere maintenance via telomere lengthening)|go:"GO:0017108"(5'-flap endonuclease activity)|go:"GO:0033557"(Slx1-Slx4 complex)|go:"GO:0046872"(metal ion binding)|go:"GO:0061820"(telomeric D-loop disassembly)|go:"GO:0090656"(t-circle formation)|go:"GO:1904357"(negative regulation of telomere maintenance via telomere lengthening)|go:"GO:1904431"(positive regulation of t-circle formation)|interpro:IPR000305(Excinuclease ABC, C subunit, N-terminal)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR027520|interpro:IPR035901|reactome:R-HSA-5693568|reactome:R-HSA-6783310	refseq:NP_115820.2|ensembl:ENSG00000188827(gene)|ensembl:ENST00000294008(transcript)|go:"GO:0000706"(meiotic DNA double-strand break processing)|go:"GO:0000712"(resolution of meiotic recombination intermediates)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003677"(DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0010792"(DNA double-strand break processing involved in repair via single-strand annealing)|go:"GO:0019899"(enzyme binding)|go:"GO:0030054"(cell junction)|go:"GO:0033557"(Slx1-Slx4 complex)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0046872"(metal ion binding)|go:"GO:0061820"(telomeric D-loop disassembly)|go:"GO:0072429"(response to intra-S DNA damage checkpoint signaling)|go:"GO:0090656"(t-circle formation)|go:"GO:1904357"(negative regulation of telomere maintenance via telomere lengthening)|go:"GO:1904431"(positive regulation of t-circle formation)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006642(Zinc finger, Rad18-type putative)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR018574|rcsb pdb:4M7C|rcsb pdb:4UYI|rcsb pdb:4ZOU|rcsb pdb:7BU5|reactome:R-HSA-5693568|reactome:R-HSA-6783310	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 6B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2009/08/04	2014/10/16	rogid:HOCvski3UnUW86f0rfOUf8fTQ8c9606	rogid:NuJHCWXHD3dfQNmsNz/LVD0UHsQ9606	intact-crc:16D44B7D24BBB88B|rigid:J3+98kZ14arGSPZEU/6OAAgIqik	false	flag tag:?-?	green fluorescent protein tag:?-?|necessary binding region:1462-1664	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8IY92	uniprotkb:Q92889	intact:EBI-2370740|uniprotkb:Q69YT8|uniprotkb:Q8TF15|uniprotkb:Q96JP1|intact:EBI-2560942|ensembl:ENSP00000294008	intact:EBI-2370770|uniprotkb:O00140|uniprotkb:Q8TD83|uniprotkb:A5PKV6|uniprotkb:A8K111|ensembl:ENSP00000310520	psi-mi:slx4_human(display_long)|uniprotkb:SLX4(gene name)|psi-mi:SLX4(display_short)|uniprotkb:BTB/POZ domain-containing protein 12(gene name synonym)|uniprotkb:BTBD12(gene name synonym)|uniprotkb:KIAA1784(gene name synonym)|uniprotkb:KIAA1987(gene name synonym)	psi-mi:xpf_human(display_long)|uniprotkb:ERCC4(gene name)|psi-mi:ERCC4(display_short)|uniprotkb:ERCC11(gene name synonym)|uniprotkb:XPF(gene name synonym)|uniprotkb:DNA excision repair protein ERCC-4(gene name synonym)|uniprotkb:DNA repair protein complementing XP-F cells(gene name synonym)|uniprotkb:Xeroderma pigmentosum group F-complementing protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Fekairi et al. (2009)	imex:IM-12201|pubmed:19596236	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2408090|imex:IM-12201-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_115820.2|ensembl:ENSG00000188827(gene)|ensembl:ENST00000294008(transcript)|go:"GO:0000706"(meiotic DNA double-strand break processing)|go:"GO:0000712"(resolution of meiotic recombination intermediates)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003677"(DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0010792"(DNA double-strand break processing involved in repair via single-strand annealing)|go:"GO:0019899"(enzyme binding)|go:"GO:0030054"(cell junction)|go:"GO:0033557"(Slx1-Slx4 complex)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0046872"(metal ion binding)|go:"GO:0061820"(telomeric D-loop disassembly)|go:"GO:0072429"(response to intra-S DNA damage checkpoint signaling)|go:"GO:0090656"(t-circle formation)|go:"GO:1904357"(negative regulation of telomere maintenance via telomere lengthening)|go:"GO:1904431"(positive regulation of t-circle formation)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006642(Zinc finger, Rad18-type putative)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR018574|rcsb pdb:4M7C|rcsb pdb:4UYI|rcsb pdb:4ZOU|rcsb pdb:7BU5|reactome:R-HSA-5693568|reactome:R-HSA-6783310	refseq:NP_005227.1|dip:DIP-42006N|ensembl:ENSG00000175595(gene)|ensembl:ENST00000311895(transcript)|go:"GO:0000014"(single-stranded DNA endodeoxyribonuclease activity)|go:"GO:0000109"(nucleotide-excision repair complex)|go:"GO:0000110"(nucleotide-excision repair factor 1 complex)|go:"GO:0000712"(resolution of meiotic recombination intermediates)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001094"(TFIID-class transcription factor complex binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0004520"(endodeoxyribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006295"(nucleotide-excision repair, DNA incision, 3'-to lesion)|go:"GO:0006296"(nucleotide-excision repair, DNA incision, 5'-to lesion)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009411"(response to UV)|go:"GO:0009650"(UV protection)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0032205"(negative regulation of telomere maintenance)|go:"GO:0033683"(nucleotide-excision repair, DNA incision)|go:"GO:0034644"(cellular response to UV)|go:"GO:0042802"(identical protein binding)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0061819"(telomeric DNA-containing double minutes formation)|go:"GO:0070522"(ERCC4-ERCC1 complex)|go:"GO:1901255"(nucleotide-excision repair involved in interstrand cross-link repair)|go:"GO:1904357"(negative regulation of telomere maintenance via telomere lengthening)|go:"GO:1905765"(negative regulation of protection from non-homologous end joining at telomere)|go:"GO:1905768"(negative regulation of double-stranded telomeric DNA binding)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR006166(DNA repair nuclease, XPF-type/Helicase)|interpro:IPR006167(DNA repair protein)|interpro:IPR010994(RuvA domain 2-like)|interpro:IPR011335(Restriction endonuclease, type II-like, core)|mint:Q92889|rcsb pdb:1Z00|rcsb pdb:2A1J|rcsb pdb:2AQ0|rcsb pdb:2KN7|rcsb pdb:2MUT|rcsb pdb:6SXA|rcsb pdb:6SXB|reactome:R-HSA-5685938|reactome:R-HSA-5696395|reactome:R-HSA-5696400|reactome:R-HSA-6782135|reactome:R-HSA-6783310	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supp. Figs. 3 and 16|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2009/08/04	2014/10/16	rogid:NuJHCWXHD3dfQNmsNz/LVD0UHsQ9606	rogid:A42t082dZNQH72TF3QRa+Msuoms9606	intact-crc:910EE5A3294FF5F8|rigid:H7npLt6dyU4j7X7Apevv2tMZTnQ	false	necessary binding region:1-683|flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8IY92	uniprotkb:P07992	intact:EBI-2370740|uniprotkb:Q69YT8|uniprotkb:Q8TF15|uniprotkb:Q96JP1|intact:EBI-2560942|ensembl:ENSP00000294008	intact:EBI-750962|ensembl:ENSP00000300853|ensembl:ENSP00000468035|uniprotkb:B2RC01|uniprotkb:B3KRR0|uniprotkb:Q7Z7F5|uniprotkb:Q96S40	psi-mi:slx4_human(display_long)|uniprotkb:SLX4(gene name)|psi-mi:SLX4(display_short)|uniprotkb:BTB/POZ domain-containing protein 12(gene name synonym)|uniprotkb:BTBD12(gene name synonym)|uniprotkb:KIAA1784(gene name synonym)|uniprotkb:KIAA1987(gene name synonym)	psi-mi:ercc1_human(display_long)|uniprotkb:ERCC1(gene name)|psi-mi:ERCC1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Fekairi et al. (2009)	imex:IM-12201|pubmed:19596236	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2408090|imex:IM-12201-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_115820.2|ensembl:ENSG00000188827(gene)|ensembl:ENST00000294008(transcript)|go:"GO:0000706"(meiotic DNA double-strand break processing)|go:"GO:0000712"(resolution of meiotic recombination intermediates)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003677"(DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0010792"(DNA double-strand break processing involved in repair via single-strand annealing)|go:"GO:0019899"(enzyme binding)|go:"GO:0030054"(cell junction)|go:"GO:0033557"(Slx1-Slx4 complex)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0046872"(metal ion binding)|go:"GO:0061820"(telomeric D-loop disassembly)|go:"GO:0072429"(response to intra-S DNA damage checkpoint signaling)|go:"GO:0090656"(t-circle formation)|go:"GO:1904357"(negative regulation of telomere maintenance via telomere lengthening)|go:"GO:1904431"(positive regulation of t-circle formation)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006642(Zinc finger, Rad18-type putative)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR018574|rcsb pdb:4M7C|rcsb pdb:4UYI|rcsb pdb:4ZOU|rcsb pdb:7BU5|reactome:R-HSA-5693568|reactome:R-HSA-6783310	refseq:NP_001974.1|ensembl:ENSG00000012061(gene)|ensembl:ENST00000300853(transcript)|ensembl:ENST00000589165(transcript)|go:"GO:0000109"(nucleotide-excision repair complex)|go:"GO:0000110"(nucleotide-excision repair factor 1 complex)|go:"GO:0000710"(meiotic mismatch repair)|go:"GO:0000720"(pyrimidine dimer repair by nucleotide-excision repair)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001094"(TFIID-class transcription factor complex binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006295"(nucleotide-excision repair, DNA incision, 3'-to lesion)|go:"GO:0006296"(nucleotide-excision repair, DNA incision, 5'-to lesion)|refseq:XP_011524912.1|refseq:NP_001159521.1|refseq:NP_973730.1|refseq:XP_005258691.1|refseq:XP_005258692.1|refseq:XP_005258693.1|refseq:XP_016881948.1|refseq:XP_016881949.1|refseq:XP_016881950.1|refseq:XP_016881951.1|refseq:XP_016881952.1|refseq:XP_016881953.1|refseq:XP_016881954.1|refseq:XP_016881955.1|dip:DIP-24235N|reactome:R-HSA-6783310|reactome:R-HSA-6782135|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006310"(DNA recombination)|go:"GO:0006312"(mitotic recombination)|go:"GO:0006949"(syncytium formation)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007584"(response to nutrient)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008584"(male gonad development)|go:"GO:0009650"(UV protection)|go:"GO:0009744"(response to sucrose)|go:"GO:0010165"(response to X-ray)|go:"GO:0010259"(multicellular organism aging)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032205"(negative regulation of telomere maintenance)|go:"GO:0035166"(post-embryonic hemopoiesis)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035902"(response to immobilization stress)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0045190"(isotype switching)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0048477"(oogenesis)|go:"GO:0048568"(embryonic organ development)|go:"GO:0060261"(positive regulation of transcription initiation from RNA polymerase II promoter)|go:"GO:0061819"(telomeric DNA-containing double minutes formation)|go:"GO:0070522"(ERCC4-ERCC1 complex)|go:"GO:0070914"(UV-damage excision repair)|go:"GO:0090399"(replicative senescence)|go:"GO:0090656"(t-circle formation)|go:"GO:1904431"(positive regulation of t-circle formation)|go:"GO:1905765"(negative regulation of protection from non-homologous end joining at telomere)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR004579(DNA repair protein rad10)|interpro:IPR010994(RuvA domain 2-like)|interpro:IPR011335(Restriction endonuclease, type II-like, core)|rcsb pdb:1Z00|rcsb pdb:2A1I|rcsb pdb:2A1J|rcsb pdb:2JNW|rcsb pdb:2JPD|rcsb pdb:2MUT|rcsb pdb:6SXA|rcsb pdb:6SXB|reactome:R-HSA-5685938|reactome:R-HSA-5696395|reactome:R-HSA-5696400	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supp. Figs. 3 and 16|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2009/08/04	2014/10/16	rogid:NuJHCWXHD3dfQNmsNz/LVD0UHsQ9606	rogid:wgacfBH+F2NRhpzRsTChE4zSPho9606	intact-crc:910EE5A3294FF5F8|rigid:H7npLt6dyU4j7X7Apevv2tMZTnQ	false	necessary binding region:1-683|flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q15554	uniprotkb:Q8IY92	intact:EBI-706637|ensembl:ENSP00000254942|intact:EBI-706651	intact:EBI-2370740|uniprotkb:Q69YT8|uniprotkb:Q8TF15|uniprotkb:Q96JP1|intact:EBI-2560942|ensembl:ENSP00000294008	psi-mi:terf2_human(display_long)|uniprotkb:TTAGGG repeat-binding factor 2(gene name synonym)|uniprotkb:Telomeric DNA-binding protein(gene name synonym)|uniprotkb:TERF2(gene name)|psi-mi:TERF2(display_short)|uniprotkb:TRF2(gene name synonym)|uniprotkb:TRBF2(gene name synonym)	psi-mi:slx4_human(display_long)|uniprotkb:SLX4(gene name)|psi-mi:SLX4(display_short)|uniprotkb:BTB/POZ domain-containing protein 12(gene name synonym)|uniprotkb:BTBD12(gene name synonym)|uniprotkb:KIAA1784(gene name synonym)|uniprotkb:KIAA1987(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Fekairi et al. (2009)	imex:IM-12201|pubmed:19596236	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2408102|imex:IM-12201-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0032206"(positive regulation of telomere maintenance)|go:"GO:0032208"(negative regulation of telomere maintenance via recombination)|go:"GO:0032210"(regulation of telomere maintenance via telomerase)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0032214"(negative regulation of telomere maintenance via semi-conservative replication)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0061820"(telomeric D-loop disassembly)|go:"GO:0070187"(shelterin complex)|go:"GO:0070198"(protein localization to chromosome, telomeric region)|go:"GO:0090398"(cellular senescence)|go:"GO:0098505"(G-rich strand telomeric DNA binding)|go:"GO:0099087"(anterograde axonal transport of messenger ribonucleoprotein complex)|go:"GO:1903770"(negative regulation of beta-galactosidase activity)|go:"GO:1903824"(negative regulation of telomere single strand break repair)|go:"GO:1904115"(axon cytoplasm)|go:"GO:0032205"(negative regulation of telomere maintenance)|reactome:R-HSA-110330|reactome:R-HSA-110331|reactome:R-HSA-1221632|reactome:R-HSA-171306|reactome:R-HSA-171319|reactome:R-HSA-174411|reactome:R-HSA-174414|reactome:R-HSA-174417|reactome:R-HSA-174430|reactome:R-HSA-174437|reactome:R-HSA-2559586|reactome:R-HSA-9670095|ensembl:ENSG00000132604(gene)|ensembl:ENST00000254942(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000783"(nuclear telomere cap complex)|go:"GO:0001673"(male germ cell nucleus)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003691"(double-stranded telomeric DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006278"(RNA-dependent DNA biosynthetic process)|go:"GO:0007049"(cell cycle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016233"(telomere capping)|go:"GO:0016604"(nuclear body)|go:"GO:0019899"(enzyme binding)|go:"GO:0031627"(telomeric loop formation)|go:"GO:0031848"(protection from non-homologous end joining at telomere)|go:"GO:0032204"(regulation of telomere maintenance)|go:"GO:1904357"(negative regulation of telomere maintenance via telomere lengthening)|go:"GO:1904430"(negative regulation of t-circle formation)|go:"GO:1905778"(negative regulation of exonuclease activity)|go:"GO:1905839"(negative regulation of telomeric D-loop disassembly)|go:"GO:2000773"(negative regulation of cellular senescence)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR009057(Homeodomain-like)|interpro:IPR013867(Telomere repeat binding factor, dimerisation)|interpro:IPR017357(Telomeric repeat-binding factor 1, Pin2)|interpro:IPR017930|interpro:IPR030657|interpro:IPR031902|interpro:IPR036507|mint:Q15554|rcsb pdb:1H6P|rcsb pdb:1VF9|rcsb pdb:1VFC|rcsb pdb:1W0U|rcsb pdb:1XG1|rcsb pdb:3BU8|rcsb pdb:3BUA|rcsb pdb:3K6G|rcsb pdb:3SJM|rcsb pdb:4M7C|rcsb pdb:4RQI|rcsb pdb:5WQD|rcsb pdb:5XYF|rcsb pdb:6J67|rcsb pdb:7C5D|reactome:R-HSA-110328|reactome:R-HSA-110329|go:"GO:1904354"(negative regulation of telomere capping)|refseq:NP_005643.2|dip:DIP-34052N	refseq:NP_115820.2|ensembl:ENSG00000188827(gene)|ensembl:ENST00000294008(transcript)|go:"GO:0000706"(meiotic DNA double-strand break processing)|go:"GO:0000712"(resolution of meiotic recombination intermediates)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003677"(DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0010792"(DNA double-strand break processing involved in repair via single-strand annealing)|go:"GO:0019899"(enzyme binding)|go:"GO:0030054"(cell junction)|go:"GO:0033557"(Slx1-Slx4 complex)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0046872"(metal ion binding)|go:"GO:0061820"(telomeric D-loop disassembly)|go:"GO:0072429"(response to intra-S DNA damage checkpoint signaling)|go:"GO:0090656"(t-circle formation)|go:"GO:1904357"(negative regulation of telomere maintenance via telomere lengthening)|go:"GO:1904431"(positive regulation of t-circle formation)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006642(Zinc finger, Rad18-type putative)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR018574|rcsb pdb:4M7C|rcsb pdb:4UYI|rcsb pdb:4ZOU|rcsb pdb:7BU5|reactome:R-HSA-5693568|reactome:R-HSA-6783310	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supp. Figs. 3 and 16|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2009/08/04	2014/10/16	rogid:MzPf3uCpzJzkIKvgaP0Xro7xnHo9606	rogid:NuJHCWXHD3dfQNmsNz/LVD0UHsQ9606	intact-crc:27CC535287D2B12F|rigid:RHV3kjbUV+XZSuUSTs9Ar27H3NM	false	-	flag tag:?-?|sufficient binding region:684-1834	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8IY92	uniprotkb:P07992	intact:EBI-2370740|uniprotkb:Q69YT8|uniprotkb:Q8TF15|uniprotkb:Q96JP1|intact:EBI-2560942|ensembl:ENSP00000294008	intact:EBI-750962|ensembl:ENSP00000300853|ensembl:ENSP00000468035|uniprotkb:B2RC01|uniprotkb:B3KRR0|uniprotkb:Q7Z7F5|uniprotkb:Q96S40	psi-mi:slx4_human(display_long)|uniprotkb:SLX4(gene name)|psi-mi:SLX4(display_short)|uniprotkb:BTB/POZ domain-containing protein 12(gene name synonym)|uniprotkb:BTBD12(gene name synonym)|uniprotkb:KIAA1784(gene name synonym)|uniprotkb:KIAA1987(gene name synonym)	psi-mi:ercc1_human(display_long)|uniprotkb:ERCC1(gene name)|psi-mi:ERCC1(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Fekairi et al. (2009)	imex:IM-12201|pubmed:19596236	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2408111|imex:IM-12201-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_115820.2|ensembl:ENSG00000188827(gene)|ensembl:ENST00000294008(transcript)|go:"GO:0000706"(meiotic DNA double-strand break processing)|go:"GO:0000712"(resolution of meiotic recombination intermediates)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003677"(DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0010792"(DNA double-strand break processing involved in repair via single-strand annealing)|go:"GO:0019899"(enzyme binding)|go:"GO:0030054"(cell junction)|go:"GO:0033557"(Slx1-Slx4 complex)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0046872"(metal ion binding)|go:"GO:0061820"(telomeric D-loop disassembly)|go:"GO:0072429"(response to intra-S DNA damage checkpoint signaling)|go:"GO:0090656"(t-circle formation)|go:"GO:1904357"(negative regulation of telomere maintenance via telomere lengthening)|go:"GO:1904431"(positive regulation of t-circle formation)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006642(Zinc finger, Rad18-type putative)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR018574|rcsb pdb:4M7C|rcsb pdb:4UYI|rcsb pdb:4ZOU|rcsb pdb:7BU5|reactome:R-HSA-5693568|reactome:R-HSA-6783310	refseq:NP_001974.1|ensembl:ENSG00000012061(gene)|ensembl:ENST00000300853(transcript)|ensembl:ENST00000589165(transcript)|go:"GO:0000109"(nucleotide-excision repair complex)|go:"GO:0000110"(nucleotide-excision repair factor 1 complex)|go:"GO:0000710"(meiotic mismatch repair)|go:"GO:0000720"(pyrimidine dimer repair by nucleotide-excision repair)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001094"(TFIID-class transcription factor complex binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006295"(nucleotide-excision repair, DNA incision, 3'-to lesion)|go:"GO:0006296"(nucleotide-excision repair, DNA incision, 5'-to lesion)|refseq:XP_011524912.1|refseq:NP_001159521.1|refseq:NP_973730.1|refseq:XP_005258691.1|refseq:XP_005258692.1|refseq:XP_005258693.1|refseq:XP_016881948.1|refseq:XP_016881949.1|refseq:XP_016881950.1|refseq:XP_016881951.1|refseq:XP_016881952.1|refseq:XP_016881953.1|refseq:XP_016881954.1|refseq:XP_016881955.1|dip:DIP-24235N|reactome:R-HSA-6783310|reactome:R-HSA-6782135|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006310"(DNA recombination)|go:"GO:0006312"(mitotic recombination)|go:"GO:0006949"(syncytium formation)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007584"(response to nutrient)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008584"(male gonad development)|go:"GO:0009650"(UV protection)|go:"GO:0009744"(response to sucrose)|go:"GO:0010165"(response to X-ray)|go:"GO:0010259"(multicellular organism aging)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032205"(negative regulation of telomere maintenance)|go:"GO:0035166"(post-embryonic hemopoiesis)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035902"(response to immobilization stress)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0045190"(isotype switching)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0048477"(oogenesis)|go:"GO:0048568"(embryonic organ development)|go:"GO:0060261"(positive regulation of transcription initiation from RNA polymerase II promoter)|go:"GO:0061819"(telomeric DNA-containing double minutes formation)|go:"GO:0070522"(ERCC4-ERCC1 complex)|go:"GO:0070914"(UV-damage excision repair)|go:"GO:0090399"(replicative senescence)|go:"GO:0090656"(t-circle formation)|go:"GO:1904431"(positive regulation of t-circle formation)|go:"GO:1905765"(negative regulation of protection from non-homologous end joining at telomere)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR004579(DNA repair protein rad10)|interpro:IPR010994(RuvA domain 2-like)|interpro:IPR011335(Restriction endonuclease, type II-like, core)|rcsb pdb:1Z00|rcsb pdb:2A1I|rcsb pdb:2A1J|rcsb pdb:2JNW|rcsb pdb:2JPD|rcsb pdb:2MUT|rcsb pdb:6SXA|rcsb pdb:6SXB|reactome:R-HSA-5685938|reactome:R-HSA-5696395|reactome:R-HSA-5696400	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supp. Figs. 3 and 16|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2009/08/04	2014/10/16	rogid:NuJHCWXHD3dfQNmsNz/LVD0UHsQ9606	rogid:wgacfBH+F2NRhpzRsTChE4zSPho9606	intact-crc:CCC08DAD79C8A745|rigid:6IGIQQMroTscZyGOQL/YScuCjog	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8IY92	uniprotkb:Q92889	intact:EBI-2370740|uniprotkb:Q69YT8|uniprotkb:Q8TF15|uniprotkb:Q96JP1|intact:EBI-2560942|ensembl:ENSP00000294008	intact:EBI-2370770|uniprotkb:O00140|uniprotkb:Q8TD83|uniprotkb:A5PKV6|uniprotkb:A8K111|ensembl:ENSP00000310520	psi-mi:slx4_human(display_long)|uniprotkb:SLX4(gene name)|psi-mi:SLX4(display_short)|uniprotkb:BTB/POZ domain-containing protein 12(gene name synonym)|uniprotkb:BTBD12(gene name synonym)|uniprotkb:KIAA1784(gene name synonym)|uniprotkb:KIAA1987(gene name synonym)	psi-mi:xpf_human(display_long)|uniprotkb:ERCC4(gene name)|psi-mi:ERCC4(display_short)|uniprotkb:ERCC11(gene name synonym)|uniprotkb:XPF(gene name synonym)|uniprotkb:DNA excision repair protein ERCC-4(gene name synonym)|uniprotkb:DNA repair protein complementing XP-F cells(gene name synonym)|uniprotkb:Xeroderma pigmentosum group F-complementing protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Fekairi et al. (2009)	imex:IM-12201|pubmed:19596236	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2408111|imex:IM-12201-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_115820.2|ensembl:ENSG00000188827(gene)|ensembl:ENST00000294008(transcript)|go:"GO:0000706"(meiotic DNA double-strand break processing)|go:"GO:0000712"(resolution of meiotic recombination intermediates)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003677"(DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0010792"(DNA double-strand break processing involved in repair via single-strand annealing)|go:"GO:0019899"(enzyme binding)|go:"GO:0030054"(cell junction)|go:"GO:0033557"(Slx1-Slx4 complex)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0046872"(metal ion binding)|go:"GO:0061820"(telomeric D-loop disassembly)|go:"GO:0072429"(response to intra-S DNA damage checkpoint signaling)|go:"GO:0090656"(t-circle formation)|go:"GO:1904357"(negative regulation of telomere maintenance via telomere lengthening)|go:"GO:1904431"(positive regulation of t-circle formation)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006642(Zinc finger, Rad18-type putative)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR018574|rcsb pdb:4M7C|rcsb pdb:4UYI|rcsb pdb:4ZOU|rcsb pdb:7BU5|reactome:R-HSA-5693568|reactome:R-HSA-6783310	refseq:NP_005227.1|dip:DIP-42006N|ensembl:ENSG00000175595(gene)|ensembl:ENST00000311895(transcript)|go:"GO:0000014"(single-stranded DNA endodeoxyribonuclease activity)|go:"GO:0000109"(nucleotide-excision repair complex)|go:"GO:0000110"(nucleotide-excision repair factor 1 complex)|go:"GO:0000712"(resolution of meiotic recombination intermediates)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001094"(TFIID-class transcription factor complex binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0004520"(endodeoxyribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006295"(nucleotide-excision repair, DNA incision, 3'-to lesion)|go:"GO:0006296"(nucleotide-excision repair, DNA incision, 5'-to lesion)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009411"(response to UV)|go:"GO:0009650"(UV protection)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0032205"(negative regulation of telomere maintenance)|go:"GO:0033683"(nucleotide-excision repair, DNA incision)|go:"GO:0034644"(cellular response to UV)|go:"GO:0042802"(identical protein binding)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0061819"(telomeric DNA-containing double minutes formation)|go:"GO:0070522"(ERCC4-ERCC1 complex)|go:"GO:1901255"(nucleotide-excision repair involved in interstrand cross-link repair)|go:"GO:1904357"(negative regulation of telomere maintenance via telomere lengthening)|go:"GO:1905765"(negative regulation of protection from non-homologous end joining at telomere)|go:"GO:1905768"(negative regulation of double-stranded telomeric DNA binding)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR006166(DNA repair nuclease, XPF-type/Helicase)|interpro:IPR006167(DNA repair protein)|interpro:IPR010994(RuvA domain 2-like)|interpro:IPR011335(Restriction endonuclease, type II-like, core)|mint:Q92889|rcsb pdb:1Z00|rcsb pdb:2A1J|rcsb pdb:2AQ0|rcsb pdb:2KN7|rcsb pdb:2MUT|rcsb pdb:6SXA|rcsb pdb:6SXB|reactome:R-HSA-5685938|reactome:R-HSA-5696395|reactome:R-HSA-5696400|reactome:R-HSA-6782135|reactome:R-HSA-6783310	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supp. Figs. 3 and 16|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2009/08/04	2014/10/16	rogid:NuJHCWXHD3dfQNmsNz/LVD0UHsQ9606	rogid:A42t082dZNQH72TF3QRa+Msuoms9606	intact-crc:CCC08DAD79C8A745|rigid:6IGIQQMroTscZyGOQL/YScuCjog	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8IY92	uniprotkb:Q15554	intact:EBI-2370740|uniprotkb:Q69YT8|uniprotkb:Q8TF15|uniprotkb:Q96JP1|intact:EBI-2560942|ensembl:ENSP00000294008	intact:EBI-706637|ensembl:ENSP00000254942|intact:EBI-706651	psi-mi:slx4_human(display_long)|uniprotkb:SLX4(gene name)|psi-mi:SLX4(display_short)|uniprotkb:BTB/POZ domain-containing protein 12(gene name synonym)|uniprotkb:BTBD12(gene name synonym)|uniprotkb:KIAA1784(gene name synonym)|uniprotkb:KIAA1987(gene name synonym)	psi-mi:terf2_human(display_long)|uniprotkb:TTAGGG repeat-binding factor 2(gene name synonym)|uniprotkb:Telomeric DNA-binding protein(gene name synonym)|uniprotkb:TERF2(gene name)|psi-mi:TERF2(display_short)|uniprotkb:TRF2(gene name synonym)|uniprotkb:TRBF2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Fekairi et al. (2009)	imex:IM-12201|pubmed:19596236	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2408111|imex:IM-12201-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_115820.2|ensembl:ENSG00000188827(gene)|ensembl:ENST00000294008(transcript)|go:"GO:0000706"(meiotic DNA double-strand break processing)|go:"GO:0000712"(resolution of meiotic recombination intermediates)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003677"(DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0010792"(DNA double-strand break processing involved in repair via single-strand annealing)|go:"GO:0019899"(enzyme binding)|go:"GO:0030054"(cell junction)|go:"GO:0033557"(Slx1-Slx4 complex)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0046872"(metal ion binding)|go:"GO:0061820"(telomeric D-loop disassembly)|go:"GO:0072429"(response to intra-S DNA damage checkpoint signaling)|go:"GO:0090656"(t-circle formation)|go:"GO:1904357"(negative regulation of telomere maintenance via telomere lengthening)|go:"GO:1904431"(positive regulation of t-circle formation)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006642(Zinc finger, Rad18-type putative)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR018574|rcsb pdb:4M7C|rcsb pdb:4UYI|rcsb pdb:4ZOU|rcsb pdb:7BU5|reactome:R-HSA-5693568|reactome:R-HSA-6783310	go:"GO:0032206"(positive regulation of telomere maintenance)|go:"GO:0032208"(negative regulation of telomere maintenance via recombination)|go:"GO:0032210"(regulation of telomere maintenance via telomerase)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0032214"(negative regulation of telomere maintenance via semi-conservative replication)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0061820"(telomeric D-loop disassembly)|go:"GO:0070187"(shelterin complex)|go:"GO:0070198"(protein localization to chromosome, telomeric region)|go:"GO:0090398"(cellular senescence)|go:"GO:0098505"(G-rich strand telomeric DNA binding)|go:"GO:0099087"(anterograde axonal transport of messenger ribonucleoprotein complex)|go:"GO:1903770"(negative regulation of beta-galactosidase activity)|go:"GO:1903824"(negative regulation of telomere single strand break repair)|go:"GO:1904115"(axon cytoplasm)|go:"GO:0032205"(negative regulation of telomere maintenance)|reactome:R-HSA-110330|reactome:R-HSA-110331|reactome:R-HSA-1221632|reactome:R-HSA-171306|reactome:R-HSA-171319|reactome:R-HSA-174411|reactome:R-HSA-174414|reactome:R-HSA-174417|reactome:R-HSA-174430|reactome:R-HSA-174437|reactome:R-HSA-2559586|reactome:R-HSA-9670095|ensembl:ENSG00000132604(gene)|ensembl:ENST00000254942(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000783"(nuclear telomere cap complex)|go:"GO:0001673"(male germ cell nucleus)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003691"(double-stranded telomeric DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006278"(RNA-dependent DNA biosynthetic process)|go:"GO:0007049"(cell cycle)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016233"(telomere capping)|go:"GO:0016604"(nuclear body)|go:"GO:0019899"(enzyme binding)|go:"GO:0031627"(telomeric loop formation)|go:"GO:0031848"(protection from non-homologous end joining at telomere)|go:"GO:0032204"(regulation of telomere maintenance)|go:"GO:1904357"(negative regulation of telomere maintenance via telomere lengthening)|go:"GO:1904430"(negative regulation of t-circle formation)|go:"GO:1905778"(negative regulation of exonuclease activity)|go:"GO:1905839"(negative regulation of telomeric D-loop disassembly)|go:"GO:2000773"(negative regulation of cellular senescence)|interpro:IPR001005(SANT, DNA-binding)|interpro:IPR009057(Homeodomain-like)|interpro:IPR013867(Telomere repeat binding factor, dimerisation)|interpro:IPR017357(Telomeric repeat-binding factor 1, Pin2)|interpro:IPR017930|interpro:IPR030657|interpro:IPR031902|interpro:IPR036507|mint:Q15554|rcsb pdb:1H6P|rcsb pdb:1VF9|rcsb pdb:1VFC|rcsb pdb:1W0U|rcsb pdb:1XG1|rcsb pdb:3BU8|rcsb pdb:3BUA|rcsb pdb:3K6G|rcsb pdb:3SJM|rcsb pdb:4M7C|rcsb pdb:4RQI|rcsb pdb:5WQD|rcsb pdb:5XYF|rcsb pdb:6J67|rcsb pdb:7C5D|reactome:R-HSA-110328|reactome:R-HSA-110329|go:"GO:1904354"(negative regulation of telomere capping)|refseq:NP_005643.2|dip:DIP-34052N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supp. Figs. 3 and 16|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2009/08/04	2014/10/16	rogid:NuJHCWXHD3dfQNmsNz/LVD0UHsQ9606	rogid:MzPf3uCpzJzkIKvgaP0Xro7xnHo9606	intact-crc:CCC08DAD79C8A745|rigid:6IGIQQMroTscZyGOQL/YScuCjog	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9BQ83	uniprotkb:Q8IY92	intact:EBI-2370858|uniprotkb:Q6NTG6|uniprotkb:B7ZME1|ensembl:ENSP00000251303|ensembl:ENSP00000328940	intact:EBI-2370740|uniprotkb:Q69YT8|uniprotkb:Q8TF15|uniprotkb:Q96JP1|intact:EBI-2560942|ensembl:ENSP00000294008	psi-mi:slx1_human(display_long)|uniprotkb:GIYD1(gene name synonym)|uniprotkb:GIYD2(gene name synonym)|uniprotkb:SLX1(gene name synonym)|uniprotkb:GIY-YIG domain-containing protein 1(gene name synonym)|uniprotkb:SLX1A(gene name)|psi-mi:SLX1A(display_short)|uniprotkb:SLX1B(gene name)|psi-mi:SLX1B(display_short)	psi-mi:slx4_human(display_long)|uniprotkb:SLX4(gene name)|psi-mi:SLX4(display_short)|uniprotkb:BTB/POZ domain-containing protein 12(gene name synonym)|uniprotkb:BTBD12(gene name synonym)|uniprotkb:KIAA1784(gene name synonym)|uniprotkb:KIAA1987(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Fekairi et al. (2009)	imex:IM-12201|pubmed:19596236	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2407989|imex:IM-12201-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001014999.1|refseq:NP_001015000.1|refseq:NP_076949.1|refseq:NP_835145.1|ensembl:ENSG00000132207(gene)|ensembl:ENSG00000181625(gene)|ensembl:ENST00000251303(transcript)|ensembl:ENST00000330181(transcript)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0008821"(crossover junction endodeoxyribonuclease activity)|go:"GO:0010792"(DNA double-strand break processing involved in repair via single-strand annealing)|go:"GO:0010833"(telomere maintenance via telomere lengthening)|go:"GO:0017108"(5'-flap endonuclease activity)|go:"GO:0033557"(Slx1-Slx4 complex)|go:"GO:0046872"(metal ion binding)|go:"GO:0061820"(telomeric D-loop disassembly)|go:"GO:0090656"(t-circle formation)|go:"GO:1904357"(negative regulation of telomere maintenance via telomere lengthening)|go:"GO:1904431"(positive regulation of t-circle formation)|interpro:IPR000305(Excinuclease ABC, C subunit, N-terminal)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR027520|interpro:IPR035901|reactome:R-HSA-5693568|reactome:R-HSA-6783310	refseq:NP_115820.2|ensembl:ENSG00000188827(gene)|ensembl:ENST00000294008(transcript)|go:"GO:0000706"(meiotic DNA double-strand break processing)|go:"GO:0000712"(resolution of meiotic recombination intermediates)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003677"(DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0010792"(DNA double-strand break processing involved in repair via single-strand annealing)|go:"GO:0019899"(enzyme binding)|go:"GO:0030054"(cell junction)|go:"GO:0033557"(Slx1-Slx4 complex)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0046872"(metal ion binding)|go:"GO:0061820"(telomeric D-loop disassembly)|go:"GO:0072429"(response to intra-S DNA damage checkpoint signaling)|go:"GO:0090656"(t-circle formation)|go:"GO:1904357"(negative regulation of telomere maintenance via telomere lengthening)|go:"GO:1904431"(positive regulation of t-circle formation)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006642(Zinc finger, Rad18-type putative)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR018574|rcsb pdb:4M7C|rcsb pdb:4UYI|rcsb pdb:4ZOU|rcsb pdb:7BU5|reactome:R-HSA-5693568|reactome:R-HSA-6783310	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 2C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2009/08/04	2014/10/16	rogid:HOCvski3UnUW86f0rfOUf8fTQ8c9606	rogid:NuJHCWXHD3dfQNmsNz/LVD0UHsQ9606	intact-crc:6AC9642E43182E9F|rigid:hOZuSPz4cE3VihVBCQuxn8bTJWM	false	flag tag:?-?	sufficient binding region:684-1834|green fluorescent protein tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q8IY92	uniprotkb:Q96NY9	intact:EBI-2370740|uniprotkb:Q69YT8|uniprotkb:Q8TF15|uniprotkb:Q96JP1|intact:EBI-2560942|ensembl:ENSP00000294008	intact:EBI-2370806|uniprotkb:Q9H7D9|ensembl:ENSP00000307853	psi-mi:slx4_human(display_long)|uniprotkb:SLX4(gene name)|psi-mi:SLX4(display_short)|uniprotkb:BTB/POZ domain-containing protein 12(gene name synonym)|uniprotkb:BTBD12(gene name synonym)|uniprotkb:KIAA1784(gene name synonym)|uniprotkb:KIAA1987(gene name synonym)	psi-mi:mus81_human(display_long)|uniprotkb:MUS81(gene name)|psi-mi:MUS81(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Fekairi et al. (2009)	imex:IM-12201|pubmed:19596236	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2408065|imex:IM-12201-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_115820.2|ensembl:ENSG00000188827(gene)|ensembl:ENST00000294008(transcript)|go:"GO:0000706"(meiotic DNA double-strand break processing)|go:"GO:0000712"(resolution of meiotic recombination intermediates)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003677"(DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0010792"(DNA double-strand break processing involved in repair via single-strand annealing)|go:"GO:0019899"(enzyme binding)|go:"GO:0030054"(cell junction)|go:"GO:0033557"(Slx1-Slx4 complex)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0046872"(metal ion binding)|go:"GO:0061820"(telomeric D-loop disassembly)|go:"GO:0072429"(response to intra-S DNA damage checkpoint signaling)|go:"GO:0090656"(t-circle formation)|go:"GO:1904357"(negative regulation of telomere maintenance via telomere lengthening)|go:"GO:1904431"(positive regulation of t-circle formation)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006642(Zinc finger, Rad18-type putative)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR018574|rcsb pdb:4M7C|rcsb pdb:4UYI|rcsb pdb:4ZOU|rcsb pdb:7BU5|reactome:R-HSA-5693568|reactome:R-HSA-6783310	refseq:XP_011543572.1|refseq:NP_079404.3|dip:DIP-48630N|ensembl:ENSG00000172732(gene)|ensembl:ENST00000308110(transcript)|go:"GO:0000712"(resolution of meiotic recombination intermediates)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0000737"(DNA catabolic process, endonucleolytic)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006281"(DNA repair)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0033687"(osteoblast proliferation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048257"(3'-flap endonuclease activity)|go:"GO:0048476"(Holliday junction resolvase complex)|go:"GO:0072429"(response to intra-S DNA damage checkpoint signaling)|interpro:IPR006166(DNA repair nuclease, XPF-type/Helicase)|interpro:IPR011335(Restriction endonuclease, type II-like, core)|interpro:IPR027421|interpro:IPR036388|interpro:IPR042530|rcsb pdb:2MC3|rcsb pdb:2ZIX|rcsb pdb:4P0P|rcsb pdb:4P0Q|rcsb pdb:4P0R|rcsb pdb:4P0S|rcsb pdb:6VWB|reactome:R-HSA-5693568|reactome:R-HSA-6783310	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 6C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2009/08/04	2014/10/16	rogid:NuJHCWXHD3dfQNmsNz/LVD0UHsQ9606	rogid:FKXIIwLeq3tNM8rOASbXwGFW7PQ9606	intact-crc:D277F15092175CB3|rigid:ePgDQntKU0Y/Q6KGxojnNZ1Nvvk	false	flag tag:?-?	ha tag:?-?|necessary binding region:1-86(IPR010996)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q96AY2	uniprotkb:Q8IY92	intact:EBI-2370825|uniprotkb:Q96N62|ensembl:ENSP00000339897|intact:EBI-28987747	intact:EBI-2370740|uniprotkb:Q69YT8|uniprotkb:Q8TF15|uniprotkb:Q96JP1|intact:EBI-2560942|ensembl:ENSP00000294008	psi-mi:eme1_human(display_long)|uniprotkb:EME1(gene name)|psi-mi:EME1(display_short)|uniprotkb:MMS4(gene name synonym)|uniprotkb:MMS4 homolog(gene name synonym)	psi-mi:slx4_human(display_long)|uniprotkb:SLX4(gene name)|psi-mi:SLX4(display_short)|uniprotkb:BTB/POZ domain-containing protein 12(gene name synonym)|uniprotkb:BTBD12(gene name synonym)|uniprotkb:KIAA1784(gene name synonym)|uniprotkb:KIAA1987(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Fekairi et al. (2009)	imex:IM-12201|pubmed:19596236	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2408079|imex:IM-12201-12	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001159603.1|refseq:NP_689676.2|ensembl:ENSP00000339897|ensembl:ENST00000393271|ensembl:ENSP00000376952|ensembl:ENST00000511648|ensembl:ENSP00000421700|ensembl:ENSG00000154920(gene)|ensembl:ENST00000338165(transcript)|go:"GO:0000712"(resolution of meiotic recombination intermediates)|go:"GO:0000792"(heterochromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006302"(double-strand break repair)|go:"GO:0031297"(replication fork processing)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0046872"(metal ion binding)|go:"GO:0048476"(Holliday junction resolvase complex)|go:"GO:0072429"(response to intra-S DNA damage checkpoint signaling)|interpro:IPR006166(DNA repair nuclease, XPF-type/Helicase)|interpro:IPR033310|interpro:IPR042530|interpro:IPR043086|rcsb pdb:2ZIU|rcsb pdb:2ZIV|rcsb pdb:2ZIW|rcsb pdb:2ZIX|rcsb pdb:4P0P|rcsb pdb:4P0Q|rcsb pdb:4P0R|rcsb pdb:4P0S|reactome:R-HSA-5693568|reactome:R-HSA-6783310|dip:DIP-48629N	refseq:NP_115820.2|ensembl:ENSG00000188827(gene)|ensembl:ENST00000294008(transcript)|go:"GO:0000706"(meiotic DNA double-strand break processing)|go:"GO:0000712"(resolution of meiotic recombination intermediates)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003677"(DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0010792"(DNA double-strand break processing involved in repair via single-strand annealing)|go:"GO:0019899"(enzyme binding)|go:"GO:0030054"(cell junction)|go:"GO:0033557"(Slx1-Slx4 complex)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0046872"(metal ion binding)|go:"GO:0061820"(telomeric D-loop disassembly)|go:"GO:0072429"(response to intra-S DNA damage checkpoint signaling)|go:"GO:0090656"(t-circle formation)|go:"GO:1904357"(negative regulation of telomere maintenance via telomere lengthening)|go:"GO:1904431"(positive regulation of t-circle formation)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006642(Zinc finger, Rad18-type putative)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR018574|rcsb pdb:4M7C|rcsb pdb:4UYI|rcsb pdb:4ZOU|rcsb pdb:7BU5|reactome:R-HSA-5693568|reactome:R-HSA-6783310	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 6D|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2009/08/04	2014/10/16	rogid:Fu8EiQUq5GaYSyW5hev133CQJe09606	rogid:NuJHCWXHD3dfQNmsNz/LVD0UHsQ9606	intact-crc:410B97686833662B|rigid:wh1l8spHztbhRgUITpLIXzA/adA	false	necessary binding region:454-558|flag tag:?-?	green fluorescent protein tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q96AY2	uniprotkb:Q96NY9	intact:EBI-2370825|uniprotkb:Q96N62|ensembl:ENSP00000339897|intact:EBI-28987747	intact:EBI-2370806|uniprotkb:Q9H7D9|ensembl:ENSP00000307853	psi-mi:eme1_human(display_long)|uniprotkb:EME1(gene name)|psi-mi:EME1(display_short)|uniprotkb:MMS4(gene name synonym)|uniprotkb:MMS4 homolog(gene name synonym)	psi-mi:mus81_human(display_long)|uniprotkb:MUS81(gene name)|psi-mi:MUS81(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Fekairi et al. (2009)	imex:IM-12201|pubmed:19596236	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2408035|imex:IM-12201-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001159603.1|refseq:NP_689676.2|ensembl:ENSP00000339897|ensembl:ENST00000393271|ensembl:ENSP00000376952|ensembl:ENST00000511648|ensembl:ENSP00000421700|ensembl:ENSG00000154920(gene)|ensembl:ENST00000338165(transcript)|go:"GO:0000712"(resolution of meiotic recombination intermediates)|go:"GO:0000792"(heterochromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006302"(double-strand break repair)|go:"GO:0031297"(replication fork processing)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0046872"(metal ion binding)|go:"GO:0048476"(Holliday junction resolvase complex)|go:"GO:0072429"(response to intra-S DNA damage checkpoint signaling)|interpro:IPR006166(DNA repair nuclease, XPF-type/Helicase)|interpro:IPR033310|interpro:IPR042530|interpro:IPR043086|rcsb pdb:2ZIU|rcsb pdb:2ZIV|rcsb pdb:2ZIW|rcsb pdb:2ZIX|rcsb pdb:4P0P|rcsb pdb:4P0Q|rcsb pdb:4P0R|rcsb pdb:4P0S|reactome:R-HSA-5693568|reactome:R-HSA-6783310|dip:DIP-48629N	refseq:XP_011543572.1|refseq:NP_079404.3|dip:DIP-48630N|ensembl:ENSG00000172732(gene)|ensembl:ENST00000308110(transcript)|go:"GO:0000712"(resolution of meiotic recombination intermediates)|go:"GO:0000727"(double-strand break repair via break-induced replication)|go:"GO:0000737"(DNA catabolic process, endonucleolytic)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006281"(DNA repair)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0033687"(osteoblast proliferation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048257"(3'-flap endonuclease activity)|go:"GO:0048476"(Holliday junction resolvase complex)|go:"GO:0072429"(response to intra-S DNA damage checkpoint signaling)|interpro:IPR006166(DNA repair nuclease, XPF-type/Helicase)|interpro:IPR011335(Restriction endonuclease, type II-like, core)|interpro:IPR027421|interpro:IPR036388|interpro:IPR042530|rcsb pdb:2MC3|rcsb pdb:2ZIX|rcsb pdb:4P0P|rcsb pdb:4P0Q|rcsb pdb:4P0R|rcsb pdb:4P0S|rcsb pdb:6VWB|reactome:R-HSA-5693568|reactome:R-HSA-6783310	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 6A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2009/08/04	2014/10/16	rogid:Fu8EiQUq5GaYSyW5hev133CQJe09606	rogid:FKXIIwLeq3tNM8rOASbXwGFW7PQ9606	intact-crc:EAA8CE02CA00E3C2|rigid:BNDNmQ25TcEND9fNQCTo3Vo1Q7s	false	flag tag:?-?	-	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:Q96AY2	uniprotkb:Q8IY92	intact:EBI-2370825|uniprotkb:Q96N62|ensembl:ENSP00000339897|intact:EBI-28987747	intact:EBI-2370740|uniprotkb:Q69YT8|uniprotkb:Q8TF15|uniprotkb:Q96JP1|intact:EBI-2560942|ensembl:ENSP00000294008	psi-mi:eme1_human(display_long)|uniprotkb:EME1(gene name)|psi-mi:EME1(display_short)|uniprotkb:MMS4(gene name synonym)|uniprotkb:MMS4 homolog(gene name synonym)	psi-mi:slx4_human(display_long)|uniprotkb:SLX4(gene name)|psi-mi:SLX4(display_short)|uniprotkb:BTB/POZ domain-containing protein 12(gene name synonym)|uniprotkb:BTBD12(gene name synonym)|uniprotkb:KIAA1784(gene name synonym)|uniprotkb:KIAA1987(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Fekairi et al. (2009)	imex:IM-12201|pubmed:19596236	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2408035|imex:IM-12201-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001159603.1|refseq:NP_689676.2|ensembl:ENSP00000339897|ensembl:ENST00000393271|ensembl:ENSP00000376952|ensembl:ENST00000511648|ensembl:ENSP00000421700|ensembl:ENSG00000154920(gene)|ensembl:ENST00000338165(transcript)|go:"GO:0000712"(resolution of meiotic recombination intermediates)|go:"GO:0000792"(heterochromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0004519"(endonuclease activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006302"(double-strand break repair)|go:"GO:0031297"(replication fork processing)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0046872"(metal ion binding)|go:"GO:0048476"(Holliday junction resolvase complex)|go:"GO:0072429"(response to intra-S DNA damage checkpoint signaling)|interpro:IPR006166(DNA repair nuclease, XPF-type/Helicase)|interpro:IPR033310|interpro:IPR042530|interpro:IPR043086|rcsb pdb:2ZIU|rcsb pdb:2ZIV|rcsb pdb:2ZIW|rcsb pdb:2ZIX|rcsb pdb:4P0P|rcsb pdb:4P0Q|rcsb pdb:4P0R|rcsb pdb:4P0S|reactome:R-HSA-5693568|reactome:R-HSA-6783310|dip:DIP-48629N	refseq:NP_115820.2|ensembl:ENSG00000188827(gene)|ensembl:ENST00000294008(transcript)|go:"GO:0000706"(meiotic DNA double-strand break processing)|go:"GO:0000712"(resolution of meiotic recombination intermediates)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003677"(DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0010792"(DNA double-strand break processing involved in repair via single-strand annealing)|go:"GO:0019899"(enzyme binding)|go:"GO:0030054"(cell junction)|go:"GO:0033557"(Slx1-Slx4 complex)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0046872"(metal ion binding)|go:"GO:0061820"(telomeric D-loop disassembly)|go:"GO:0072429"(response to intra-S DNA damage checkpoint signaling)|go:"GO:0090656"(t-circle formation)|go:"GO:1904357"(negative regulation of telomere maintenance via telomere lengthening)|go:"GO:1904431"(positive regulation of t-circle formation)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006642(Zinc finger, Rad18-type putative)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR018574|rcsb pdb:4M7C|rcsb pdb:4UYI|rcsb pdb:4ZOU|rcsb pdb:7BU5|reactome:R-HSA-5693568|reactome:R-HSA-6783310	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 6A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2009/08/04	2014/10/16	rogid:Fu8EiQUq5GaYSyW5hev133CQJe09606	rogid:NuJHCWXHD3dfQNmsNz/LVD0UHsQ9606	intact-crc:EAA8CE02CA00E3C2|rigid:BNDNmQ25TcEND9fNQCTo3Vo1Q7s	false	flag tag:?-?	-	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:Q8IY92	uniprotkb:Q9BQ83	intact:EBI-2370740|uniprotkb:Q69YT8|uniprotkb:Q8TF15|uniprotkb:Q96JP1|intact:EBI-2560942|ensembl:ENSP00000294008	intact:EBI-2370858|uniprotkb:Q6NTG6|uniprotkb:B7ZME1|ensembl:ENSP00000251303|ensembl:ENSP00000328940	psi-mi:slx4_human(display_long)|uniprotkb:SLX4(gene name)|psi-mi:SLX4(display_short)|uniprotkb:BTB/POZ domain-containing protein 12(gene name synonym)|uniprotkb:BTBD12(gene name synonym)|uniprotkb:KIAA1784(gene name synonym)|uniprotkb:KIAA1987(gene name synonym)	psi-mi:slx1_human(display_long)|uniprotkb:GIYD1(gene name synonym)|uniprotkb:GIYD2(gene name synonym)|uniprotkb:SLX1(gene name synonym)|uniprotkb:GIY-YIG domain-containing protein 1(gene name synonym)|uniprotkb:SLX1A(gene name)|psi-mi:SLX1A(display_short)|uniprotkb:SLX1B(gene name)|psi-mi:SLX1B(display_short)	psi-mi:"MI:0663"(confocal microscopy)	Fekairi et al. (2009)	imex:IM-12201|pubmed:19596236	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2408131|imex:IM-12201-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_115820.2|ensembl:ENSG00000188827(gene)|ensembl:ENST00000294008(transcript)|go:"GO:0000706"(meiotic DNA double-strand break processing)|go:"GO:0000712"(resolution of meiotic recombination intermediates)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003677"(DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0008047"(enzyme activator activity)|go:"GO:0010792"(DNA double-strand break processing involved in repair via single-strand annealing)|go:"GO:0019899"(enzyme binding)|go:"GO:0030054"(cell junction)|go:"GO:0033557"(Slx1-Slx4 complex)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0046872"(metal ion binding)|go:"GO:0061820"(telomeric D-loop disassembly)|go:"GO:0072429"(response to intra-S DNA damage checkpoint signaling)|go:"GO:0090656"(t-circle formation)|go:"GO:1904357"(negative regulation of telomere maintenance via telomere lengthening)|go:"GO:1904431"(positive regulation of t-circle formation)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006642(Zinc finger, Rad18-type putative)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR018574|rcsb pdb:4M7C|rcsb pdb:4UYI|rcsb pdb:4ZOU|rcsb pdb:7BU5|reactome:R-HSA-5693568|reactome:R-HSA-6783310	refseq:NP_001014999.1|refseq:NP_001015000.1|refseq:NP_076949.1|refseq:NP_835145.1|ensembl:ENSG00000132207(gene)|ensembl:ENSG00000181625(gene)|ensembl:ENST00000251303(transcript)|ensembl:ENST00000330181(transcript)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0008821"(crossover junction endodeoxyribonuclease activity)|go:"GO:0010792"(DNA double-strand break processing involved in repair via single-strand annealing)|go:"GO:0010833"(telomere maintenance via telomere lengthening)|go:"GO:0017108"(5'-flap endonuclease activity)|go:"GO:0033557"(Slx1-Slx4 complex)|go:"GO:0046872"(metal ion binding)|go:"GO:0061820"(telomeric D-loop disassembly)|go:"GO:0090656"(t-circle formation)|go:"GO:1904357"(negative regulation of telomere maintenance via telomere lengthening)|go:"GO:1904431"(positive regulation of t-circle formation)|interpro:IPR000305(Excinuclease ABC, C subunit, N-terminal)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR027520|interpro:IPR035901|reactome:R-HSA-5693568|reactome:R-HSA-6783310	go:"GO:0005634"(nucleus)	-	-	figure legend:Supp. Fig. 2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mrc5)|taxid:9606(Human foetal lung fibroblast-like cell line)	-	2009/08/04	2014/10/16	rogid:NuJHCWXHD3dfQNmsNz/LVD0UHsQ9606	rogid:HOCvski3UnUW86f0rfOUf8fTQ8c9606	intact-crc:BBFE3B6E39E70176|rigid:hOZuSPz4cE3VihVBCQuxn8bTJWM	false	green fluorescent protein tag:?-?	flag tag:?-?	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)