#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P97377	uniprotkb:P51943	intact:EBI-847048|uniprotkb:O55105|ensembl:ENSMUSP00000026416	intact:EBI-846980|uniprotkb:Q8BRG1|uniprotkb:Q61459|ensembl:ENSMUSP00000029270	psi-mi:cdk2_mouse(display_long)|uniprotkb:Cdk2(gene name)|psi-mi:Cdk2(display_short)|uniprotkb:Cell division protein kinase 2(gene name synonym)|uniprotkb:Cdkn2(gene name synonym)	psi-mi:ccna2_mouse(display_long)|uniprotkb:Ccna2(gene name)|psi-mi:Ccna2(display_short)|uniprotkb:Ccna(gene name synonym)|uniprotkb:Cyca(gene name synonym)|uniprotkb:Cyca2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kalaszczynska et al. (2009)	imex:IM-12205|pubmed:19592082	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2409805|imex:IM-12205-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_058036.1|refseq:NP_904326.1|dip:DIP-24176N|ensembl:ENSMUSG00000025358(gene)|ensembl:ENSMUST00000026416(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000793"(condensed chromosome)|go:"GO:0000805"(X chromosome)|go:"GO:0000806"(Y chromosome)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007099"(centriole replication)|go:"GO:0007165"(signal transduction)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010389"(regulation of G2/M transition of mitotic cell cycle)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0015030"(Cajal body)|go:"GO:0016301"(kinase activity)|go:"GO:0016572"(histone phosphorylation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030332"(cyclin binding)|go:"GO:0032298"(positive regulation of DNA-dependent DNA replication initiation)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051301"(cell division)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0051591"(response to cAMP)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060968"(obsolete regulation of gene silencing)|go:"GO:0097123"(cyclin A1-CDK2 complex)|go:"GO:0097124"(cyclin A2-CDK2 complex)|go:"GO:0097134"(cyclin E1-CDK2 complex)|go:"GO:0097135"(cyclin E2-CDK2 complex)|go:"GO:0097472"(cyclin-dependent protein kinase activity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P97377|reactome:R-MMU-1538133|reactome:R-MMU-171319|reactome:R-MMU-176187|reactome:R-MMU-176408|reactome:R-MMU-187577|reactome:R-MMU-2559582|reactome:R-MMU-2559586|reactome:R-MMU-5693607|reactome:R-MMU-6804116|reactome:R-MMU-6804756|reactome:R-MMU-6804757|reactome:R-MMU-68911|reactome:R-MMU-68949|reactome:R-MMU-68962|reactome:R-MMU-69017|reactome:R-MMU-69200|reactome:R-MMU-69202|reactome:R-MMU-69231|reactome:R-MMU-69273|reactome:R-MMU-69563|reactome:R-MMU-69656|reactome:R-MMU-8849470|reactome:R-MMU-9616222	refseq:XP_017174933.1|refseq:NP_033958.2|dip:DIP-45864N|ensembl:ENSMUSG00000027715(gene)|ensembl:ENSMUST00000029270(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0001939"(female pronucleus)|go:"GO:0001940"(male pronucleus)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0016572"(histone phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0033762"(response to glucagon)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0044772"(mitotic cell cycle phase transition)|go:"GO:0044843"(cell cycle G1/S phase transition)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0051301"(cell division)|go:"GO:0071314"(cellular response to cocaine)|go:"GO:0071373"(cellular response to luteinizing hormone stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0090102"(cochlea development)|go:"GO:0097124"(cyclin A2-CDK2 complex)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|interpro:IPR004367(Cyclin, C-terminal)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR013763(Cyclin-related)|interpro:IPR032447|interpro:IPR036915|interpro:IPR039361|rcsb pdb:3QHR|rcsb pdb:3QHW|rcsb pdb:4I3Z|rcsb pdb:4II5|reactome:R-MMU-1538133|reactome:R-MMU-171319|reactome:R-MMU-174184|reactome:R-MMU-176408|reactome:R-MMU-187577|reactome:R-MMU-2559582|reactome:R-MMU-2559586|reactome:R-MMU-5689880|reactome:R-MMU-5693607|reactome:R-MMU-6804116|reactome:R-MMU-6804756|reactome:R-MMU-6804757|reactome:R-MMU-68911|reactome:R-MMU-68949|reactome:R-MMU-69017|reactome:R-MMU-69273|reactome:R-MMU-69563|reactome:R-MMU-69656	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 7E|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2009/08/10	2014/10/16	rogid:jCcs8BtuHFzuhQ5Ps1+OSaWn64g10090	rogid:sv/Fwt0MyArIyVzTjmw2t++8hE410090	intact-crc:3CEBDA3926EEDFF8|rigid:DkeB0L6yHSRME1WRS2qAtwTOMoI	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P97377	uniprotkb:Q61457	intact:EBI-847048|uniprotkb:O55105|ensembl:ENSMUSP00000026416	intact:EBI-643090|uniprotkb:Q05BA1|uniprotkb:Q05BA6|uniprotkb:Q05BB7|ensembl:ENSMUSP00000103658	psi-mi:cdk2_mouse(display_long)|uniprotkb:Cdk2(gene name)|psi-mi:Cdk2(display_short)|uniprotkb:Cell division protein kinase 2(gene name synonym)|uniprotkb:Cdkn2(gene name synonym)	psi-mi:ccne1_mouse(display_long)|uniprotkb:Ccne1(gene name)|psi-mi:Ccne1(display_short)|uniprotkb:Ccne(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kalaszczynska et al. (2009)	imex:IM-12205|pubmed:19592082	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2409809|imex:IM-12205-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_058036.1|refseq:NP_904326.1|dip:DIP-24176N|ensembl:ENSMUSG00000025358(gene)|ensembl:ENSMUST00000026416(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000793"(condensed chromosome)|go:"GO:0000805"(X chromosome)|go:"GO:0000806"(Y chromosome)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007099"(centriole replication)|go:"GO:0007165"(signal transduction)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010389"(regulation of G2/M transition of mitotic cell cycle)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0015030"(Cajal body)|go:"GO:0016301"(kinase activity)|go:"GO:0016572"(histone phosphorylation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030332"(cyclin binding)|go:"GO:0032298"(positive regulation of DNA-dependent DNA replication initiation)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051301"(cell division)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0051591"(response to cAMP)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060968"(obsolete regulation of gene silencing)|go:"GO:0097123"(cyclin A1-CDK2 complex)|go:"GO:0097124"(cyclin A2-CDK2 complex)|go:"GO:0097134"(cyclin E1-CDK2 complex)|go:"GO:0097135"(cyclin E2-CDK2 complex)|go:"GO:0097472"(cyclin-dependent protein kinase activity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P97377|reactome:R-MMU-1538133|reactome:R-MMU-171319|reactome:R-MMU-176187|reactome:R-MMU-176408|reactome:R-MMU-187577|reactome:R-MMU-2559582|reactome:R-MMU-2559586|reactome:R-MMU-5693607|reactome:R-MMU-6804116|reactome:R-MMU-6804756|reactome:R-MMU-6804757|reactome:R-MMU-68911|reactome:R-MMU-68949|reactome:R-MMU-68962|reactome:R-MMU-69017|reactome:R-MMU-69200|reactome:R-MMU-69202|reactome:R-MMU-69231|reactome:R-MMU-69273|reactome:R-MMU-69563|reactome:R-MMU-69656|reactome:R-MMU-8849470|reactome:R-MMU-9616222	refseq:NP_031659.2|ensembl:ENSMUSG00000002068(gene)|ensembl:ENSMUST00000108023(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0000723"(telomere maintenance)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007129"(homologous chromosome pairing at meiosis)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016301"(kinase activity)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0044772"(mitotic cell cycle phase transition)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0051301"(cell division)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070192"(chromosome organization involved in meiotic cell cycle)|go:"GO:0097134"(cyclin E1-CDK2 complex)|go:"GO:1902462"(positive regulation of mesenchymal stem cell proliferation)|go:"GO:1903827"|interpro:IPR004367(Cyclin, C-terminal)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR013763(Cyclin-related)|interpro:IPR028858|interpro:IPR036915|interpro:IPR039361|mint:Q61457|reactome:R-MMU-1538133|reactome:R-MMU-187577|reactome:R-MMU-2559586|reactome:R-MMU-6804116|reactome:R-MMU-69017|reactome:R-MMU-69200|reactome:R-MMU-69202|reactome:R-MMU-69231|reactome:R-MMU-69563|reactome:R-MMU-8849470|reactome:R-MMU-9706019|dip:DIP-45868N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 7E, 7G|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2009/08/10	2014/10/16	rogid:jCcs8BtuHFzuhQ5Ps1+OSaWn64g10090	rogid:xSi4shI5OjbHkude4aCAmrzr/u410090	intact-crc:67D4BE65F392ACDE|rigid:cVpEuv4L06ozptccs3VmQjw7Rvg	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P11440	uniprotkb:Q61457	intact:EBI-846949|uniprotkb:Q3TI12|uniprotkb:P70337|ensembl:ENSMUSP00000020099|ensembl:ENSMUSP00000113184	intact:EBI-643090|uniprotkb:Q05BA1|uniprotkb:Q05BA6|uniprotkb:Q05BB7|ensembl:ENSMUSP00000103658	psi-mi:cdk1_mouse(display_long)|uniprotkb:p34 protein kinase(gene name synonym)|uniprotkb:Cell division protein kinase 1(gene name synonym)|uniprotkb:Cdk1(gene name)|psi-mi:Cdk1(display_short)|uniprotkb:Cdc2a(gene name synonym)|uniprotkb:Cdc2(gene name synonym)|uniprotkb:Cell division control protein 2 homolog(gene name synonym)|uniprotkb:Cdkn1(gene name synonym)	psi-mi:ccne1_mouse(display_long)|uniprotkb:Ccne1(gene name)|psi-mi:Ccne1(display_short)|uniprotkb:Ccne(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kalaszczynska et al. (2009)	imex:IM-12205|pubmed:19592082	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2409843|imex:IM-12205-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031685.2|dip:DIP-38725N|ensembl:ENSMUSG00000019942(gene)|ensembl:ENSMUST00000020099(transcript)|ensembl:ENSMUST00000119827(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0003682"(chromatin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005876"(spindle microtubule)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0007569"(cell aging)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0016301"(kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030261"(chromosome condensation)|go:"GO:0030332"(cyclin binding)|go:"GO:0030496"(midbody)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0034501"(protein localization to kinetochore)|go:"GO:0035173"(histone kinase activity)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044772"(mitotic cell cycle phase transition)|go:"GO:0045471"(response to ethanol)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0048511"(rhythmic process)|go:"GO:0051301"(cell division)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090166"(Golgi disassembly)|go:"GO:0097125"(cyclin B1-CDK1 complex)|go:"GO:0097472"(cyclin-dependent protein kinase activity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1905448"(positive regulation of mitochondrial ATP synthesis coupled electron transport)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P11440|reactome:R-MMU-110056|reactome:R-MMU-174048|reactome:R-MMU-174184|reactome:R-MMU-176408|reactome:R-MMU-176412|reactome:R-MMU-176417|reactome:R-MMU-2299718|reactome:R-MMU-2500257|reactome:R-MMU-2565942|reactome:R-MMU-2980767|reactome:R-MMU-2995383|reactome:R-MMU-3301854|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-380320|reactome:R-MMU-4419969|reactome:R-MMU-5620912|reactome:R-MMU-5687128|reactome:R-MMU-5689896|reactome:R-MMU-6804114|reactome:R-MMU-6804757|reactome:R-MMU-68875|reactome:R-MMU-69273|reactome:R-MMU-69478|reactome:R-MMU-75035|reactome:R-MMU-8852276|reactome:R-MMU-8854518|reactome:R-MMU-8878166	refseq:NP_031659.2|ensembl:ENSMUSG00000002068(gene)|ensembl:ENSMUST00000108023(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0000723"(telomere maintenance)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007129"(homologous chromosome pairing at meiosis)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016301"(kinase activity)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0044772"(mitotic cell cycle phase transition)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0051301"(cell division)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070192"(chromosome organization involved in meiotic cell cycle)|go:"GO:0097134"(cyclin E1-CDK2 complex)|go:"GO:1902462"(positive regulation of mesenchymal stem cell proliferation)|go:"GO:1903827"|interpro:IPR004367(Cyclin, C-terminal)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR013763(Cyclin-related)|interpro:IPR028858|interpro:IPR036915|interpro:IPR039361|mint:Q61457|reactome:R-MMU-1538133|reactome:R-MMU-187577|reactome:R-MMU-2559586|reactome:R-MMU-6804116|reactome:R-MMU-69017|reactome:R-MMU-69200|reactome:R-MMU-69202|reactome:R-MMU-69231|reactome:R-MMU-69563|reactome:R-MMU-8849470|reactome:R-MMU-9706019|dip:DIP-45868N	psi-mi:"MI:0469"(intact)	-	-	figure legend:7G|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2009/08/10	2014/10/16	rogid:YLS0FzcbPcyxmR3rOh2IJxdPNn010090	rogid:xSi4shI5OjbHkude4aCAmrzr/u410090	intact-crc:805AD7212F21899B|rigid:mgV/XQkr3TI/mXMsoePh2yI93/w	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P51943	uniprotkb:P11440	intact:EBI-846980|uniprotkb:Q8BRG1|uniprotkb:Q61459|ensembl:ENSMUSP00000029270	intact:EBI-846949|uniprotkb:Q3TI12|uniprotkb:P70337|ensembl:ENSMUSP00000020099|ensembl:ENSMUSP00000113184	psi-mi:ccna2_mouse(display_long)|uniprotkb:Ccna2(gene name)|psi-mi:Ccna2(display_short)|uniprotkb:Ccna(gene name synonym)|uniprotkb:Cyca(gene name synonym)|uniprotkb:Cyca2(gene name synonym)	psi-mi:cdk1_mouse(display_long)|uniprotkb:p34 protein kinase(gene name synonym)|uniprotkb:Cell division protein kinase 1(gene name synonym)|uniprotkb:Cdk1(gene name)|psi-mi:Cdk1(display_short)|uniprotkb:Cdc2a(gene name synonym)|uniprotkb:Cdc2(gene name synonym)|uniprotkb:Cell division control protein 2 homolog(gene name synonym)|uniprotkb:Cdkn1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kalaszczynska et al. (2009)	imex:IM-12205|pubmed:19592082	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2409853|imex:IM-12205-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_017174933.1|refseq:NP_033958.2|dip:DIP-45864N|ensembl:ENSMUSG00000027715(gene)|ensembl:ENSMUST00000029270(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0001939"(female pronucleus)|go:"GO:0001940"(male pronucleus)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0016572"(histone phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0033762"(response to glucagon)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0044772"(mitotic cell cycle phase transition)|go:"GO:0044843"(cell cycle G1/S phase transition)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0051301"(cell division)|go:"GO:0071314"(cellular response to cocaine)|go:"GO:0071373"(cellular response to luteinizing hormone stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0090102"(cochlea development)|go:"GO:0097124"(cyclin A2-CDK2 complex)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|interpro:IPR004367(Cyclin, C-terminal)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR013763(Cyclin-related)|interpro:IPR032447|interpro:IPR036915|interpro:IPR039361|rcsb pdb:3QHR|rcsb pdb:3QHW|rcsb pdb:4I3Z|rcsb pdb:4II5|reactome:R-MMU-1538133|reactome:R-MMU-171319|reactome:R-MMU-174184|reactome:R-MMU-176408|reactome:R-MMU-187577|reactome:R-MMU-2559582|reactome:R-MMU-2559586|reactome:R-MMU-5689880|reactome:R-MMU-5693607|reactome:R-MMU-6804116|reactome:R-MMU-6804756|reactome:R-MMU-6804757|reactome:R-MMU-68911|reactome:R-MMU-68949|reactome:R-MMU-69017|reactome:R-MMU-69273|reactome:R-MMU-69563|reactome:R-MMU-69656	refseq:NP_031685.2|dip:DIP-38725N|ensembl:ENSMUSG00000019942(gene)|ensembl:ENSMUST00000020099(transcript)|ensembl:ENSMUST00000119827(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0003682"(chromatin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005876"(spindle microtubule)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0007569"(cell aging)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0016301"(kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030261"(chromosome condensation)|go:"GO:0030332"(cyclin binding)|go:"GO:0030496"(midbody)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0034501"(protein localization to kinetochore)|go:"GO:0035173"(histone kinase activity)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044772"(mitotic cell cycle phase transition)|go:"GO:0045471"(response to ethanol)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0048511"(rhythmic process)|go:"GO:0051301"(cell division)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090166"(Golgi disassembly)|go:"GO:0097125"(cyclin B1-CDK1 complex)|go:"GO:0097472"(cyclin-dependent protein kinase activity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1905448"(positive regulation of mitochondrial ATP synthesis coupled electron transport)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P11440|reactome:R-MMU-110056|reactome:R-MMU-174048|reactome:R-MMU-174184|reactome:R-MMU-176408|reactome:R-MMU-176412|reactome:R-MMU-176417|reactome:R-MMU-2299718|reactome:R-MMU-2500257|reactome:R-MMU-2565942|reactome:R-MMU-2980767|reactome:R-MMU-2995383|reactome:R-MMU-3301854|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-380320|reactome:R-MMU-4419969|reactome:R-MMU-5620912|reactome:R-MMU-5687128|reactome:R-MMU-5689896|reactome:R-MMU-6804114|reactome:R-MMU-6804757|reactome:R-MMU-68875|reactome:R-MMU-69273|reactome:R-MMU-69478|reactome:R-MMU-75035|reactome:R-MMU-8852276|reactome:R-MMU-8854518|reactome:R-MMU-8878166	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 7E|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2009/08/10	2014/10/16	rogid:sv/Fwt0MyArIyVzTjmw2t++8hE410090	rogid:YLS0FzcbPcyxmR3rOh2IJxdPNn010090	intact-crc:07905C9082266FF5|rigid:zwbjP9C2MNFlwuaYTRX/m2rqfrY	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P51943	uniprotkb:P97377	intact:EBI-846980|uniprotkb:Q8BRG1|uniprotkb:Q61459|ensembl:ENSMUSP00000029270	intact:EBI-847048|uniprotkb:O55105|ensembl:ENSMUSP00000026416	psi-mi:ccna2_mouse(display_long)|uniprotkb:Ccna2(gene name)|psi-mi:Ccna2(display_short)|uniprotkb:Ccna(gene name synonym)|uniprotkb:Cyca(gene name synonym)|uniprotkb:Cyca2(gene name synonym)	psi-mi:cdk2_mouse(display_long)|uniprotkb:Cdk2(gene name)|psi-mi:Cdk2(display_short)|uniprotkb:Cell division protein kinase 2(gene name synonym)|uniprotkb:Cdkn2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kalaszczynska et al. (2009)	imex:IM-12205|pubmed:19592082	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2409822|imex:IM-12205-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_017174933.1|refseq:NP_033958.2|dip:DIP-45864N|ensembl:ENSMUSG00000027715(gene)|ensembl:ENSMUST00000029270(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0001939"(female pronucleus)|go:"GO:0001940"(male pronucleus)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0016572"(histone phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0033762"(response to glucagon)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0044772"(mitotic cell cycle phase transition)|go:"GO:0044843"(cell cycle G1/S phase transition)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0051301"(cell division)|go:"GO:0071314"(cellular response to cocaine)|go:"GO:0071373"(cellular response to luteinizing hormone stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0090102"(cochlea development)|go:"GO:0097124"(cyclin A2-CDK2 complex)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|interpro:IPR004367(Cyclin, C-terminal)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR013763(Cyclin-related)|interpro:IPR032447|interpro:IPR036915|interpro:IPR039361|rcsb pdb:3QHR|rcsb pdb:3QHW|rcsb pdb:4I3Z|rcsb pdb:4II5|reactome:R-MMU-1538133|reactome:R-MMU-171319|reactome:R-MMU-174184|reactome:R-MMU-176408|reactome:R-MMU-187577|reactome:R-MMU-2559582|reactome:R-MMU-2559586|reactome:R-MMU-5689880|reactome:R-MMU-5693607|reactome:R-MMU-6804116|reactome:R-MMU-6804756|reactome:R-MMU-6804757|reactome:R-MMU-68911|reactome:R-MMU-68949|reactome:R-MMU-69017|reactome:R-MMU-69273|reactome:R-MMU-69563|reactome:R-MMU-69656	refseq:NP_058036.1|refseq:NP_904326.1|dip:DIP-24176N|ensembl:ENSMUSG00000025358(gene)|ensembl:ENSMUST00000026416(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000793"(condensed chromosome)|go:"GO:0000805"(X chromosome)|go:"GO:0000806"(Y chromosome)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007099"(centriole replication)|go:"GO:0007165"(signal transduction)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010389"(regulation of G2/M transition of mitotic cell cycle)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0015030"(Cajal body)|go:"GO:0016301"(kinase activity)|go:"GO:0016572"(histone phosphorylation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030332"(cyclin binding)|go:"GO:0032298"(positive regulation of DNA-dependent DNA replication initiation)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051301"(cell division)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0051591"(response to cAMP)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060968"(obsolete regulation of gene silencing)|go:"GO:0097123"(cyclin A1-CDK2 complex)|go:"GO:0097124"(cyclin A2-CDK2 complex)|go:"GO:0097134"(cyclin E1-CDK2 complex)|go:"GO:0097135"(cyclin E2-CDK2 complex)|go:"GO:0097472"(cyclin-dependent protein kinase activity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P97377|reactome:R-MMU-1538133|reactome:R-MMU-171319|reactome:R-MMU-176187|reactome:R-MMU-176408|reactome:R-MMU-187577|reactome:R-MMU-2559582|reactome:R-MMU-2559586|reactome:R-MMU-5693607|reactome:R-MMU-6804116|reactome:R-MMU-6804756|reactome:R-MMU-6804757|reactome:R-MMU-68911|reactome:R-MMU-68949|reactome:R-MMU-68962|reactome:R-MMU-69017|reactome:R-MMU-69200|reactome:R-MMU-69202|reactome:R-MMU-69231|reactome:R-MMU-69273|reactome:R-MMU-69563|reactome:R-MMU-69656|reactome:R-MMU-8849470|reactome:R-MMU-9616222	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 7E|caution:"The Cyclin A2 observed in this interaction is described as a shorter (38kDa) form than normally observed but this isoform is not present in UniProtKB."|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-bone-marrow)|taxid:10090(Mouse bone marrow)	-	2009/08/10	2014/10/16	rogid:sv/Fwt0MyArIyVzTjmw2t++8hE410090	rogid:jCcs8BtuHFzuhQ5Ps1+OSaWn64g10090	intact-crc:60870809391C64DD|rigid:DkeB0L6yHSRME1WRS2qAtwTOMoI	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q61457	uniprotkb:P97377	intact:EBI-643090|uniprotkb:Q05BA1|uniprotkb:Q05BA6|uniprotkb:Q05BB7|ensembl:ENSMUSP00000103658	intact:EBI-847048|uniprotkb:O55105|ensembl:ENSMUSP00000026416	psi-mi:ccne1_mouse(display_long)|uniprotkb:Ccne1(gene name)|psi-mi:Ccne1(display_short)|uniprotkb:Ccne(gene name synonym)	psi-mi:cdk2_mouse(display_long)|uniprotkb:Cdk2(gene name)|psi-mi:Cdk2(display_short)|uniprotkb:Cell division protein kinase 2(gene name synonym)|uniprotkb:Cdkn2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kalaszczynska et al. (2009)	imex:IM-12205|pubmed:19592082	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2409834|imex:IM-12205-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031659.2|ensembl:ENSMUSG00000002068(gene)|ensembl:ENSMUST00000108023(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0000723"(telomere maintenance)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007129"(homologous chromosome pairing at meiosis)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016301"(kinase activity)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0044772"(mitotic cell cycle phase transition)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0051301"(cell division)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070192"(chromosome organization involved in meiotic cell cycle)|go:"GO:0097134"(cyclin E1-CDK2 complex)|go:"GO:1902462"(positive regulation of mesenchymal stem cell proliferation)|go:"GO:1903827"|interpro:IPR004367(Cyclin, C-terminal)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR013763(Cyclin-related)|interpro:IPR028858|interpro:IPR036915|interpro:IPR039361|mint:Q61457|reactome:R-MMU-1538133|reactome:R-MMU-187577|reactome:R-MMU-2559586|reactome:R-MMU-6804116|reactome:R-MMU-69017|reactome:R-MMU-69200|reactome:R-MMU-69202|reactome:R-MMU-69231|reactome:R-MMU-69563|reactome:R-MMU-8849470|reactome:R-MMU-9706019|dip:DIP-45868N	refseq:NP_058036.1|refseq:NP_904326.1|dip:DIP-24176N|ensembl:ENSMUSG00000025358(gene)|ensembl:ENSMUST00000026416(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000793"(condensed chromosome)|go:"GO:0000805"(X chromosome)|go:"GO:0000806"(Y chromosome)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007099"(centriole replication)|go:"GO:0007165"(signal transduction)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010389"(regulation of G2/M transition of mitotic cell cycle)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0015030"(Cajal body)|go:"GO:0016301"(kinase activity)|go:"GO:0016572"(histone phosphorylation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030332"(cyclin binding)|go:"GO:0032298"(positive regulation of DNA-dependent DNA replication initiation)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051301"(cell division)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0051591"(response to cAMP)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060968"(obsolete regulation of gene silencing)|go:"GO:0097123"(cyclin A1-CDK2 complex)|go:"GO:0097124"(cyclin A2-CDK2 complex)|go:"GO:0097134"(cyclin E1-CDK2 complex)|go:"GO:0097135"(cyclin E2-CDK2 complex)|go:"GO:0097472"(cyclin-dependent protein kinase activity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P97377|reactome:R-MMU-1538133|reactome:R-MMU-171319|reactome:R-MMU-176187|reactome:R-MMU-176408|reactome:R-MMU-187577|reactome:R-MMU-2559582|reactome:R-MMU-2559586|reactome:R-MMU-5693607|reactome:R-MMU-6804116|reactome:R-MMU-6804756|reactome:R-MMU-6804757|reactome:R-MMU-68911|reactome:R-MMU-68949|reactome:R-MMU-68962|reactome:R-MMU-69017|reactome:R-MMU-69200|reactome:R-MMU-69202|reactome:R-MMU-69231|reactome:R-MMU-69273|reactome:R-MMU-69563|reactome:R-MMU-69656|reactome:R-MMU-8849470|reactome:R-MMU-9616222	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 7E, 7G|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell)	-	2009/08/10	2014/10/16	rogid:xSi4shI5OjbHkude4aCAmrzr/u410090	rogid:jCcs8BtuHFzuhQ5Ps1+OSaWn64g10090	intact-crc:34515BDD439DFAF1|rigid:cVpEuv4L06ozptccs3VmQjw7Rvg	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P51943	uniprotkb:P97377	intact:EBI-846980|uniprotkb:Q8BRG1|uniprotkb:Q61459|ensembl:ENSMUSP00000029270	intact:EBI-847048|uniprotkb:O55105|ensembl:ENSMUSP00000026416	psi-mi:ccna2_mouse(display_long)|uniprotkb:Ccna2(gene name)|psi-mi:Ccna2(display_short)|uniprotkb:Ccna(gene name synonym)|uniprotkb:Cyca(gene name synonym)|uniprotkb:Cyca2(gene name synonym)	psi-mi:cdk2_mouse(display_long)|uniprotkb:Cdk2(gene name)|psi-mi:Cdk2(display_short)|uniprotkb:Cell division protein kinase 2(gene name synonym)|uniprotkb:Cdkn2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kalaszczynska et al. (2009)	imex:IM-12205|pubmed:19592082	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2409839|imex:IM-12205-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_017174933.1|refseq:NP_033958.2|dip:DIP-45864N|ensembl:ENSMUSG00000027715(gene)|ensembl:ENSMUST00000029270(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0001939"(female pronucleus)|go:"GO:0001940"(male pronucleus)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0016572"(histone phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0033762"(response to glucagon)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0044772"(mitotic cell cycle phase transition)|go:"GO:0044843"(cell cycle G1/S phase transition)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0051301"(cell division)|go:"GO:0071314"(cellular response to cocaine)|go:"GO:0071373"(cellular response to luteinizing hormone stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0090102"(cochlea development)|go:"GO:0097124"(cyclin A2-CDK2 complex)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|interpro:IPR004367(Cyclin, C-terminal)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR013763(Cyclin-related)|interpro:IPR032447|interpro:IPR036915|interpro:IPR039361|rcsb pdb:3QHR|rcsb pdb:3QHW|rcsb pdb:4I3Z|rcsb pdb:4II5|reactome:R-MMU-1538133|reactome:R-MMU-171319|reactome:R-MMU-174184|reactome:R-MMU-176408|reactome:R-MMU-187577|reactome:R-MMU-2559582|reactome:R-MMU-2559586|reactome:R-MMU-5689880|reactome:R-MMU-5693607|reactome:R-MMU-6804116|reactome:R-MMU-6804756|reactome:R-MMU-6804757|reactome:R-MMU-68911|reactome:R-MMU-68949|reactome:R-MMU-69017|reactome:R-MMU-69273|reactome:R-MMU-69563|reactome:R-MMU-69656	refseq:NP_058036.1|refseq:NP_904326.1|dip:DIP-24176N|ensembl:ENSMUSG00000025358(gene)|ensembl:ENSMUST00000026416(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000793"(condensed chromosome)|go:"GO:0000805"(X chromosome)|go:"GO:0000806"(Y chromosome)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006813"(potassium ion transport)|go:"GO:0007099"(centriole replication)|go:"GO:0007165"(signal transduction)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010389"(regulation of G2/M transition of mitotic cell cycle)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0015030"(Cajal body)|go:"GO:0016301"(kinase activity)|go:"GO:0016572"(histone phosphorylation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030332"(cyclin binding)|go:"GO:0032298"(positive regulation of DNA-dependent DNA replication initiation)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051301"(cell division)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0051591"(response to cAMP)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0060968"(obsolete regulation of gene silencing)|go:"GO:0097123"(cyclin A1-CDK2 complex)|go:"GO:0097124"(cyclin A2-CDK2 complex)|go:"GO:0097134"(cyclin E1-CDK2 complex)|go:"GO:0097135"(cyclin E2-CDK2 complex)|go:"GO:0097472"(cyclin-dependent protein kinase activity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P97377|reactome:R-MMU-1538133|reactome:R-MMU-171319|reactome:R-MMU-176187|reactome:R-MMU-176408|reactome:R-MMU-187577|reactome:R-MMU-2559582|reactome:R-MMU-2559586|reactome:R-MMU-5693607|reactome:R-MMU-6804116|reactome:R-MMU-6804756|reactome:R-MMU-6804757|reactome:R-MMU-68911|reactome:R-MMU-68949|reactome:R-MMU-68962|reactome:R-MMU-69017|reactome:R-MMU-69200|reactome:R-MMU-69202|reactome:R-MMU-69231|reactome:R-MMU-69273|reactome:R-MMU-69563|reactome:R-MMU-69656|reactome:R-MMU-8849470|reactome:R-MMU-9616222	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 7E|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell)	-	2009/08/10	2014/10/16	rogid:sv/Fwt0MyArIyVzTjmw2t++8hE410090	rogid:jCcs8BtuHFzuhQ5Ps1+OSaWn64g10090	intact-crc:A21F0E272CE0681B|rigid:DkeB0L6yHSRME1WRS2qAtwTOMoI	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P11440	uniprotkb:Q61457	intact:EBI-846949|uniprotkb:Q3TI12|uniprotkb:P70337|ensembl:ENSMUSP00000020099|ensembl:ENSMUSP00000113184	intact:EBI-643090|uniprotkb:Q05BA1|uniprotkb:Q05BA6|uniprotkb:Q05BB7|ensembl:ENSMUSP00000103658	psi-mi:cdk1_mouse(display_long)|uniprotkb:p34 protein kinase(gene name synonym)|uniprotkb:Cell division protein kinase 1(gene name synonym)|uniprotkb:Cdk1(gene name)|psi-mi:Cdk1(display_short)|uniprotkb:Cdc2a(gene name synonym)|uniprotkb:Cdc2(gene name synonym)|uniprotkb:Cell division control protein 2 homolog(gene name synonym)|uniprotkb:Cdkn1(gene name synonym)	psi-mi:ccne1_mouse(display_long)|uniprotkb:Ccne1(gene name)|psi-mi:Ccne1(display_short)|uniprotkb:Ccne(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kalaszczynska et al. (2009)	imex:IM-12205|pubmed:19592082	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2409848|imex:IM-12205-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031685.2|dip:DIP-38725N|ensembl:ENSMUSG00000019942(gene)|ensembl:ENSMUST00000020099(transcript)|ensembl:ENSMUST00000119827(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0003682"(chromatin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005876"(spindle microtubule)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0007569"(cell aging)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0016301"(kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030261"(chromosome condensation)|go:"GO:0030332"(cyclin binding)|go:"GO:0030496"(midbody)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0034501"(protein localization to kinetochore)|go:"GO:0035173"(histone kinase activity)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044772"(mitotic cell cycle phase transition)|go:"GO:0045471"(response to ethanol)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0048511"(rhythmic process)|go:"GO:0051301"(cell division)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090166"(Golgi disassembly)|go:"GO:0097125"(cyclin B1-CDK1 complex)|go:"GO:0097472"(cyclin-dependent protein kinase activity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1905448"(positive regulation of mitochondrial ATP synthesis coupled electron transport)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P11440|reactome:R-MMU-110056|reactome:R-MMU-174048|reactome:R-MMU-174184|reactome:R-MMU-176408|reactome:R-MMU-176412|reactome:R-MMU-176417|reactome:R-MMU-2299718|reactome:R-MMU-2500257|reactome:R-MMU-2565942|reactome:R-MMU-2980767|reactome:R-MMU-2995383|reactome:R-MMU-3301854|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-380320|reactome:R-MMU-4419969|reactome:R-MMU-5620912|reactome:R-MMU-5687128|reactome:R-MMU-5689896|reactome:R-MMU-6804114|reactome:R-MMU-6804757|reactome:R-MMU-68875|reactome:R-MMU-69273|reactome:R-MMU-69478|reactome:R-MMU-75035|reactome:R-MMU-8852276|reactome:R-MMU-8854518|reactome:R-MMU-8878166	refseq:NP_031659.2|ensembl:ENSMUSG00000002068(gene)|ensembl:ENSMUST00000108023(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0000723"(telomere maintenance)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007129"(homologous chromosome pairing at meiosis)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016301"(kinase activity)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0044772"(mitotic cell cycle phase transition)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0051301"(cell division)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070192"(chromosome organization involved in meiotic cell cycle)|go:"GO:0097134"(cyclin E1-CDK2 complex)|go:"GO:1902462"(positive regulation of mesenchymal stem cell proliferation)|go:"GO:1903827"|interpro:IPR004367(Cyclin, C-terminal)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR013763(Cyclin-related)|interpro:IPR028858|interpro:IPR036915|interpro:IPR039361|mint:Q61457|reactome:R-MMU-1538133|reactome:R-MMU-187577|reactome:R-MMU-2559586|reactome:R-MMU-6804116|reactome:R-MMU-69017|reactome:R-MMU-69200|reactome:R-MMU-69202|reactome:R-MMU-69231|reactome:R-MMU-69563|reactome:R-MMU-8849470|reactome:R-MMU-9706019|dip:DIP-45868N	psi-mi:"MI:0469"(intact)	-	-	figure legend:7G|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell)	-	2009/08/10	2014/10/16	rogid:YLS0FzcbPcyxmR3rOh2IJxdPNn010090	rogid:xSi4shI5OjbHkude4aCAmrzr/u410090	intact-crc:AF86F60D7D08CCC1|rigid:mgV/XQkr3TI/mXMsoePh2yI93/w	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P11440	uniprotkb:P51943	intact:EBI-846949|uniprotkb:Q3TI12|uniprotkb:P70337|ensembl:ENSMUSP00000020099|ensembl:ENSMUSP00000113184	intact:EBI-846980|uniprotkb:Q8BRG1|uniprotkb:Q61459|ensembl:ENSMUSP00000029270	psi-mi:cdk1_mouse(display_long)|uniprotkb:p34 protein kinase(gene name synonym)|uniprotkb:Cell division protein kinase 1(gene name synonym)|uniprotkb:Cdk1(gene name)|psi-mi:Cdk1(display_short)|uniprotkb:Cdc2a(gene name synonym)|uniprotkb:Cdc2(gene name synonym)|uniprotkb:Cell division control protein 2 homolog(gene name synonym)|uniprotkb:Cdkn1(gene name synonym)	psi-mi:ccna2_mouse(display_long)|uniprotkb:Ccna2(gene name)|psi-mi:Ccna2(display_short)|uniprotkb:Ccna(gene name synonym)|uniprotkb:Cyca(gene name synonym)|uniprotkb:Cyca2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kalaszczynska et al. (2009)	imex:IM-12205|pubmed:19592082	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2409858|imex:IM-12205-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031685.2|dip:DIP-38725N|ensembl:ENSMUSG00000019942(gene)|ensembl:ENSMUST00000020099(transcript)|ensembl:ENSMUST00000119827(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0003682"(chromatin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005876"(spindle microtubule)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0007569"(cell aging)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0010243"(response to organonitrogen compound)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0016301"(kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030261"(chromosome condensation)|go:"GO:0030332"(cyclin binding)|go:"GO:0030496"(midbody)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0034501"(protein localization to kinetochore)|go:"GO:0035173"(histone kinase activity)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044772"(mitotic cell cycle phase transition)|go:"GO:0045471"(response to ethanol)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0048511"(rhythmic process)|go:"GO:0051301"(cell division)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090166"(Golgi disassembly)|go:"GO:0097125"(cyclin B1-CDK1 complex)|go:"GO:0097472"(cyclin-dependent protein kinase activity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1905448"(positive regulation of mitochondrial ATP synthesis coupled electron transport)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P11440|reactome:R-MMU-110056|reactome:R-MMU-174048|reactome:R-MMU-174184|reactome:R-MMU-176408|reactome:R-MMU-176412|reactome:R-MMU-176417|reactome:R-MMU-2299718|reactome:R-MMU-2500257|reactome:R-MMU-2565942|reactome:R-MMU-2980767|reactome:R-MMU-2995383|reactome:R-MMU-3301854|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-380320|reactome:R-MMU-4419969|reactome:R-MMU-5620912|reactome:R-MMU-5687128|reactome:R-MMU-5689896|reactome:R-MMU-6804114|reactome:R-MMU-6804757|reactome:R-MMU-68875|reactome:R-MMU-69273|reactome:R-MMU-69478|reactome:R-MMU-75035|reactome:R-MMU-8852276|reactome:R-MMU-8854518|reactome:R-MMU-8878166	refseq:XP_017174933.1|refseq:NP_033958.2|dip:DIP-45864N|ensembl:ENSMUSG00000027715(gene)|ensembl:ENSMUST00000029270(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0001939"(female pronucleus)|go:"GO:0001940"(male pronucleus)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0016572"(histone phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0033762"(response to glucagon)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0044772"(mitotic cell cycle phase transition)|go:"GO:0044843"(cell cycle G1/S phase transition)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0051301"(cell division)|go:"GO:0071314"(cellular response to cocaine)|go:"GO:0071373"(cellular response to luteinizing hormone stimulus)|go:"GO:0071392"(cellular response to estradiol stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0090102"(cochlea development)|go:"GO:0097124"(cyclin A2-CDK2 complex)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|interpro:IPR004367(Cyclin, C-terminal)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR013763(Cyclin-related)|interpro:IPR032447|interpro:IPR036915|interpro:IPR039361|rcsb pdb:3QHR|rcsb pdb:3QHW|rcsb pdb:4I3Z|rcsb pdb:4II5|reactome:R-MMU-1538133|reactome:R-MMU-171319|reactome:R-MMU-174184|reactome:R-MMU-176408|reactome:R-MMU-187577|reactome:R-MMU-2559582|reactome:R-MMU-2559586|reactome:R-MMU-5689880|reactome:R-MMU-5693607|reactome:R-MMU-6804116|reactome:R-MMU-6804756|reactome:R-MMU-6804757|reactome:R-MMU-68911|reactome:R-MMU-68949|reactome:R-MMU-69017|reactome:R-MMU-69273|reactome:R-MMU-69563|reactome:R-MMU-69656	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 7E|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_stem cell)|taxid:10090(Mus musculus embryonic stem cell)	-	2009/08/10	2014/10/16	rogid:YLS0FzcbPcyxmR3rOh2IJxdPNn010090	rogid:sv/Fwt0MyArIyVzTjmw2t++8hE410090	intact-crc:97B13DA5579A7F57|rigid:zwbjP9C2MNFlwuaYTRX/m2rqfrY	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)