#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q8IZF0	uniprotkb:P20309	intact:EBI-7085333|intact:EBI-28978687|intact:UNK-5480197|uniprotkb:Q6ZMI7|uniprotkb:Q8TAH1|uniprotkb:Q8IZZ1|intact:UNK-5489410|intact:UNK-5519461|uniprotkb:Q6P2S6|intact:UNK-5519520|ensembl:ENSP00000251127	intact:EBI-2687785|uniprotkb:Q0VAJ8|uniprotkb:Q9HB60|uniprotkb:Q4QRI3|uniprotkb:Q5VXY2|ensembl:ENSP00000255380|ensembl:ENSP00000482377|ensembl:ENSP00000502013|ensembl:ENSP00000502349|ensembl:ENSP00000502667	psi-mi:nalcn_human(display_long)|uniprotkb:NALCN(gene name)|psi-mi:NALCN(display_short)|uniprotkb:VGCNL1(gene name synonym)|uniprotkb:Voltage gated channel-like protein 1(gene name synonym)|uniprotkb:CanIon(gene name synonym)	psi-mi:acm3_human(display_long)|uniprotkb:CHRM3(gene name)|psi-mi:CHRM3(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Swayne et al. (2009)	pubmed:19575010|imex:IM-13871|mint:MINT-7255430|doi:10.1038/embor.2009.125	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7085362|mint:MINT-7255436|imex:IM-13871-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000251127|ensembl:ENST00000376200|ensembl:ENSP00000365373|refseq:XP_011519370.1|refseq:NP_443099.1|ensembl:ENSG00000102452(gene)|ensembl:ENST00000251127(transcript)|go:"GO:0005244"(voltage-gated ion channel activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005272"(sodium channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022840"(leak channel activity)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0060075"(regulation of resting membrane potential)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071805"(potassium ion transmembrane transport)|interpro:IPR005821(Ion transport)|interpro:IPR027359|interpro:IPR028823|mint:Q8IZF0|rcsb pdb:6XIW|rcsb pdb:7CM3|reactome:R-HSA-2672351|mint:MINT-7255439(identity)	refseq:XP_011542343.1|refseq:XP_011542345.1|refseq:XP_011542346.1|refseq:XP_011542348.1|refseq:XP_011542349.1|refseq:NP_000731.1|refseq:NP_001334645.1|refseq:XP_005273089.1|ensembl:ENSG00000133019(gene)|ensembl:ENST00000255380(transcript)|ensembl:ENST00000615928(transcript)|ensembl:ENST00000675184(transcript)|ensembl:ENST00000676433(transcript)|go:"GO:0003056"(regulation of vascular associated smooth muscle contraction)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004993"(G protein-coupled serotonin receptor activity)|ensembl:ENST00000676153(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007197"(adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0007213"(G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007399"(nervous system development)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016907"(G protein-coupled acetylcholine receptor activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0032412"(regulation of ion transmembrane transporter activity)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042166"(acetylcholine binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045987"(positive regulation of smooth muscle contraction)|go:"GO:0046541"(saliva secretion)|go:"GO:0095500"(acetylcholine receptor signaling pathway)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000995(Muscarinic acetylcholine receptor)|interpro:IPR001183(Muscarinic acetylcholine receptor M3)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P20309|rcsb pdb:2CSA|reactome:R-HSA-390648|reactome:R-HSA-399997|reactome:R-HSA-416476|refseq:XP_016855641.1|refseq:XP_016855642.1|refseq:XP_016855643.1|refseq:XP_016855644.1|refseq:XP_016855645.1|refseq:XP_016855646.1|refseq:XP_016855647.1|refseq:XP_016855648.1|refseq:XP_016855649.1|refseq:XP_016855650.1|refseq:XP_016855651.1|refseq:XP_016855652.1|dip:DIP-44291N|mint:MINT-7255438(identity)	-	function:Voltage-independent, cation-nonselective channel which is permeable to sodium, potassium and calcium ions. Responsible for the background sodium ion leak current in neurons and controls neuronal excitability|comment:mint	-	figure legend:F4A|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2009/08/06	2014/10/16	rogid:rYZgwadPBpblosBgQscPlJ3m5IM9606	rogid:/arNBsrkXe4KcqIqBw4BEwYZHt49606	intact-crc:ED21ACC0B51F8E58|rigid:55Zf4vJqleVj3palrnQSrSyJkFY	false	ha tag:?-?(MINT-7255445)	flag tag:?-?(MINT-7255441)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q8IZF0	uniprotkb:P20309	intact:EBI-7085333|intact:EBI-28978687|intact:UNK-5480197|uniprotkb:Q6ZMI7|uniprotkb:Q8TAH1|uniprotkb:Q8IZZ1|intact:UNK-5489410|intact:UNK-5519461|uniprotkb:Q6P2S6|intact:UNK-5519520|ensembl:ENSP00000251127	intact:EBI-2687785|uniprotkb:Q0VAJ8|uniprotkb:Q9HB60|uniprotkb:Q4QRI3|uniprotkb:Q5VXY2|ensembl:ENSP00000255380|ensembl:ENSP00000482377|ensembl:ENSP00000502013|ensembl:ENSP00000502349|ensembl:ENSP00000502667	psi-mi:nalcn_human(display_long)|uniprotkb:NALCN(gene name)|psi-mi:NALCN(display_short)|uniprotkb:VGCNL1(gene name synonym)|uniprotkb:Voltage gated channel-like protein 1(gene name synonym)|uniprotkb:CanIon(gene name synonym)	psi-mi:acm3_human(display_long)|uniprotkb:CHRM3(gene name)|psi-mi:CHRM3(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Swayne et al. (2009)	pubmed:19575010|imex:IM-13871|mint:MINT-7255430|doi:10.1038/embor.2009.125	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7085396|mint:MINT-7255449|imex:IM-13871-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000251127|ensembl:ENST00000376200|ensembl:ENSP00000365373|refseq:XP_011519370.1|refseq:NP_443099.1|ensembl:ENSG00000102452(gene)|ensembl:ENST00000251127(transcript)|go:"GO:0005244"(voltage-gated ion channel activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005272"(sodium channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022840"(leak channel activity)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0060075"(regulation of resting membrane potential)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071805"(potassium ion transmembrane transport)|interpro:IPR005821(Ion transport)|interpro:IPR027359|interpro:IPR028823|mint:Q8IZF0|rcsb pdb:6XIW|rcsb pdb:7CM3|reactome:R-HSA-2672351|mint:MINT-7255451(identity)	refseq:XP_011542343.1|refseq:XP_011542345.1|refseq:XP_011542346.1|refseq:XP_011542348.1|refseq:XP_011542349.1|refseq:NP_000731.1|refseq:NP_001334645.1|refseq:XP_005273089.1|ensembl:ENSG00000133019(gene)|ensembl:ENST00000255380(transcript)|ensembl:ENST00000615928(transcript)|ensembl:ENST00000675184(transcript)|ensembl:ENST00000676433(transcript)|go:"GO:0003056"(regulation of vascular associated smooth muscle contraction)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004993"(G protein-coupled serotonin receptor activity)|ensembl:ENST00000676153(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007197"(adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0007213"(G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007399"(nervous system development)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016907"(G protein-coupled acetylcholine receptor activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0032412"(regulation of ion transmembrane transporter activity)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042166"(acetylcholine binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045987"(positive regulation of smooth muscle contraction)|go:"GO:0046541"(saliva secretion)|go:"GO:0095500"(acetylcholine receptor signaling pathway)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000995(Muscarinic acetylcholine receptor)|interpro:IPR001183(Muscarinic acetylcholine receptor M3)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P20309|rcsb pdb:2CSA|reactome:R-HSA-390648|reactome:R-HSA-399997|reactome:R-HSA-416476|refseq:XP_016855641.1|refseq:XP_016855642.1|refseq:XP_016855643.1|refseq:XP_016855644.1|refseq:XP_016855645.1|refseq:XP_016855646.1|refseq:XP_016855647.1|refseq:XP_016855648.1|refseq:XP_016855649.1|refseq:XP_016855650.1|refseq:XP_016855651.1|refseq:XP_016855652.1|dip:DIP-44291N|mint:MINT-7255455(identity)	-	function:Voltage-independent, cation-nonselective channel which is permeable to sodium, potassium and calcium ions. Responsible for the background sodium ion leak current in neurons and controls neuronal excitability|comment:mint	-	figure legend:F4B|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2009/08/06	2014/10/16	rogid:rYZgwadPBpblosBgQscPlJ3m5IM9606	rogid:/arNBsrkXe4KcqIqBw4BEwYZHt49606	intact-crc:7F6A0DFBF902FD4B|rigid:55Zf4vJqleVj3palrnQSrSyJkFY	false	green fluorescent protein tag:?-?(MINT-7255452)	flag tag:?-?(MINT-7255456)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q8IZF0	uniprotkb:P20309	intact:EBI-7085333|intact:EBI-28978687|intact:UNK-5480197|uniprotkb:Q6ZMI7|uniprotkb:Q8TAH1|uniprotkb:Q8IZZ1|intact:UNK-5489410|intact:UNK-5519461|uniprotkb:Q6P2S6|intact:UNK-5519520|ensembl:ENSP00000251127	intact:EBI-2687785|uniprotkb:Q0VAJ8|uniprotkb:Q9HB60|uniprotkb:Q4QRI3|uniprotkb:Q5VXY2|ensembl:ENSP00000255380|ensembl:ENSP00000482377|ensembl:ENSP00000502013|ensembl:ENSP00000502349|ensembl:ENSP00000502667	psi-mi:nalcn_human(display_long)|uniprotkb:NALCN(gene name)|psi-mi:NALCN(display_short)|uniprotkb:VGCNL1(gene name synonym)|uniprotkb:Voltage gated channel-like protein 1(gene name synonym)|uniprotkb:CanIon(gene name synonym)	psi-mi:acm3_human(display_long)|uniprotkb:CHRM3(gene name)|psi-mi:CHRM3(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Swayne et al. (2009)	pubmed:19575010|imex:IM-13871|mint:MINT-7255430|doi:10.1038/embor.2009.125	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7085414|mint:MINT-7255462|imex:IM-13871-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSP00000251127|ensembl:ENST00000376200|ensembl:ENSP00000365373|refseq:XP_011519370.1|refseq:NP_443099.1|ensembl:ENSG00000102452(gene)|ensembl:ENST00000251127(transcript)|go:"GO:0005244"(voltage-gated ion channel activity)|go:"GO:0005261"(cation channel activity)|go:"GO:0005272"(sodium channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0022840"(leak channel activity)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0060075"(regulation of resting membrane potential)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071805"(potassium ion transmembrane transport)|interpro:IPR005821(Ion transport)|interpro:IPR027359|interpro:IPR028823|mint:Q8IZF0|rcsb pdb:6XIW|rcsb pdb:7CM3|reactome:R-HSA-2672351|mint:MINT-7255468(identity)	refseq:XP_011542343.1|refseq:XP_011542345.1|refseq:XP_011542346.1|refseq:XP_011542348.1|refseq:XP_011542349.1|refseq:NP_000731.1|refseq:NP_001334645.1|refseq:XP_005273089.1|ensembl:ENSG00000133019(gene)|ensembl:ENST00000255380(transcript)|ensembl:ENST00000615928(transcript)|ensembl:ENST00000675184(transcript)|ensembl:ENST00000676433(transcript)|go:"GO:0003056"(regulation of vascular associated smooth muscle contraction)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004993"(G protein-coupled serotonin receptor activity)|ensembl:ENST00000676153(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0007197"(adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0007213"(G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007399"(nervous system development)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016907"(G protein-coupled acetylcholine receptor activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0030425"(dendrite)|go:"GO:0030594"(neurotransmitter receptor activity)|go:"GO:0032412"(regulation of ion transmembrane transporter activity)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042166"(acetylcholine binding)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045987"(positive regulation of smooth muscle contraction)|go:"GO:0046541"(saliva secretion)|go:"GO:0095500"(acetylcholine receptor signaling pathway)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR000995(Muscarinic acetylcholine receptor)|interpro:IPR001183(Muscarinic acetylcholine receptor M3)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:P20309|rcsb pdb:2CSA|reactome:R-HSA-390648|reactome:R-HSA-399997|reactome:R-HSA-416476|refseq:XP_016855641.1|refseq:XP_016855642.1|refseq:XP_016855643.1|refseq:XP_016855644.1|refseq:XP_016855645.1|refseq:XP_016855646.1|refseq:XP_016855647.1|refseq:XP_016855648.1|refseq:XP_016855649.1|refseq:XP_016855650.1|refseq:XP_016855651.1|refseq:XP_016855652.1|dip:DIP-44291N|mint:MINT-7255464(identity)	-	function:Voltage-independent, cation-nonselective channel which is permeable to sodium, potassium and calcium ions. Responsible for the background sodium ion leak current in neurons and controls neuronal excitability|comment:mint	-	figure legend:F4C|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2009/08/06	2014/10/16	rogid:rYZgwadPBpblosBgQscPlJ3m5IM9606	rogid:/arNBsrkXe4KcqIqBw4BEwYZHt49606	intact-crc:EB0622AABFF9313D|rigid:55Zf4vJqleVj3palrnQSrSyJkFY	false	ha tag:?-?(MINT-7255469)	green fluorescent protein tag:?-?(MINT-7255465)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)