#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
chebi:"CHEBI:42977"	uniprotkb:O15118	intact:EBI-2368702	intact:EBI-2368710|uniprotkb:Q9P130|uniprotkb:B4DET3|ensembl:ENSP00000269228	psi-mi:25-hydroxycholestero(display_short)|psi-mi:"CHEBI:42977"(display_long)	psi-mi:npc1_human(display_long)|uniprotkb:NPC1(gene name)|psi-mi:NPC1(display_short)|uniprotkb:Niemann-Pick C1 protein(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Kwon et al. (2009)	pubmed:19563754|imex:IM-20332	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2368748|wwpdb:3GKJ|imex:IM-20332-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_000262.2|dip:DIP-53217N|ensembl:ENSG00000141458(gene)|ensembl:ENST00000269228(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006486"(protein glycosylation)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0007041"(lysosomal transport)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0008206"(bile acid metabolic process)|go:"GO:0010467"(gene expression)|go:"GO:0015248"(sterol transporter activity)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0030301"(cholesterol transport)|go:"GO:0031579"(membrane raft organization)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032367"(intracellular cholesterol transport)|go:"GO:0033344"(cholesterol efflux)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042493"|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0045121"(membrane raft)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071383"(cellular response to steroid hormone stimulus)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0090150"(establishment of protein localization to membrane)|go:"GO:1905103"(integral component of lysosomal membrane)|interpro:IPR000731(Sterol-sensing 5TM box)|interpro:IPR003392(Patched)|interpro:IPR004765(Niemann-Pick C type protein)|interpro:IPR032190|rcsb pdb:3GKH|rcsb pdb:3GKI|rcsb pdb:3GKJ|rcsb pdb:3JD8|rcsb pdb:5F18|rcsb pdb:5F1B|rcsb pdb:5HNS|rcsb pdb:5JNX|rcsb pdb:5KWY|rcsb pdb:5U73|rcsb pdb:5U74|rcsb pdb:6UOX|rcsb pdb:6W5R|rcsb pdb:6W5S|rcsb pdb:6W5T|rcsb pdb:6W5U|rcsb pdb:6W5V|reactome:R-HSA-8964038	-	-	-	3d-resolution:1.6A|3d-r-factors:"R-factor: 17.661%, Free R-factor: 20.295%"|figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/07/23	2014/10/16	-	rogid:3kG4MGzeShC2D5FsPoZZm1lEGlk9606	intact-crc:026059FCF7B40E21	false	-	sufficient binding region:23-252|mutation:70-70|mutation:122-122|mutation:185-185|his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:16113"	uniprotkb:O15118	intact:EBI-2368700	intact:EBI-2368710|uniprotkb:Q9P130|uniprotkb:B4DET3|ensembl:ENSP00000269228	psi-mi:cholesterol(display_short)|psi-mi:"CHEBI:16113"(display_long)	psi-mi:npc1_human(display_long)|uniprotkb:NPC1(gene name)|psi-mi:NPC1(display_short)|uniprotkb:Niemann-Pick C1 protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Kwon et al. (2009)	pubmed:19563754|imex:IM-20332	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2368907|imex:IM-20332-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_000262.2|dip:DIP-53217N|ensembl:ENSG00000141458(gene)|ensembl:ENST00000269228(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006486"(protein glycosylation)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0007041"(lysosomal transport)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0008206"(bile acid metabolic process)|go:"GO:0010467"(gene expression)|go:"GO:0015248"(sterol transporter activity)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0030301"(cholesterol transport)|go:"GO:0031579"(membrane raft organization)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032367"(intracellular cholesterol transport)|go:"GO:0033344"(cholesterol efflux)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042493"|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0045121"(membrane raft)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071383"(cellular response to steroid hormone stimulus)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0090150"(establishment of protein localization to membrane)|go:"GO:1905103"(integral component of lysosomal membrane)|interpro:IPR000731(Sterol-sensing 5TM box)|interpro:IPR003392(Patched)|interpro:IPR004765(Niemann-Pick C type protein)|interpro:IPR032190|rcsb pdb:3GKH|rcsb pdb:3GKI|rcsb pdb:3GKJ|rcsb pdb:3JD8|rcsb pdb:5F18|rcsb pdb:5F1B|rcsb pdb:5HNS|rcsb pdb:5JNX|rcsb pdb:5KWY|rcsb pdb:5U73|rcsb pdb:5U74|rcsb pdb:6UOX|rcsb pdb:6W5R|rcsb pdb:6W5S|rcsb pdb:6W5T|rcsb pdb:6W5U|rcsb pdb:6W5V|reactome:R-HSA-8964038	go:"GO:0015485"(cholesterol binding)	-	-	figure legend:Fig. 5A, Supp. Fig. 5B|comment:Cholesterol is [3H] radio-labelled.|comment:Indicated mutations showed binding that was less than 25% of wild-type.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/07/23	2014/10/16	-	rogid:3kG4MGzeShC2D5FsPoZZm1lEGlk9606	intact-crc:8549B8977DE9003A	false	-	mutation decreasing interaction:202-203|his tag:c-c|flag tag:c-c|mutation decreasing interaction:39-41|mutation decreasing interaction:82-83|mutation decreasing interaction:106-108|mutation decreasing interaction:197-198|mutation decreasing interaction:204-205	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:42977"	uniprotkb:O15118	intact:EBI-2368702	intact:EBI-2368710|uniprotkb:Q9P130|uniprotkb:B4DET3|ensembl:ENSP00000269228	psi-mi:25-hydroxycholestero(display_short)|psi-mi:"CHEBI:42977"(display_long)	psi-mi:npc1_human(display_long)|uniprotkb:NPC1(gene name)|psi-mi:NPC1(display_short)|uniprotkb:Niemann-Pick C1 protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Kwon et al. (2009)	pubmed:19563754|imex:IM-20332	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2368926|imex:IM-20332-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_000262.2|dip:DIP-53217N|ensembl:ENSG00000141458(gene)|ensembl:ENST00000269228(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006486"(protein glycosylation)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0007041"(lysosomal transport)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0008206"(bile acid metabolic process)|go:"GO:0010467"(gene expression)|go:"GO:0015248"(sterol transporter activity)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0030301"(cholesterol transport)|go:"GO:0031579"(membrane raft organization)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032367"(intracellular cholesterol transport)|go:"GO:0033344"(cholesterol efflux)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042493"|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0045121"(membrane raft)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071383"(cellular response to steroid hormone stimulus)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0090150"(establishment of protein localization to membrane)|go:"GO:1905103"(integral component of lysosomal membrane)|interpro:IPR000731(Sterol-sensing 5TM box)|interpro:IPR003392(Patched)|interpro:IPR004765(Niemann-Pick C type protein)|interpro:IPR032190|rcsb pdb:3GKH|rcsb pdb:3GKI|rcsb pdb:3GKJ|rcsb pdb:3JD8|rcsb pdb:5F18|rcsb pdb:5F1B|rcsb pdb:5HNS|rcsb pdb:5JNX|rcsb pdb:5KWY|rcsb pdb:5U73|rcsb pdb:5U74|rcsb pdb:6UOX|rcsb pdb:6W5R|rcsb pdb:6W5S|rcsb pdb:6W5T|rcsb pdb:6W5U|rcsb pdb:6W5V|reactome:R-HSA-8964038	-	-	-	figure legend:Fig. 5A, Supp Fig. 5|comment:Cholesterol is [3H] radio-labelled.|comment:Mutated residues showed binding that was less than 25% of wild-type.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/07/23	2014/10/16	-	rogid:3kG4MGzeShC2D5FsPoZZm1lEGlk9606	intact-crc:FCAF0E934135FB90	false	-	mutation decreasing interaction:26-27|mutation decreasing interaction:82-83|mutation decreasing interaction:101-102|mutation decreasing interaction:106-108|mutation disrupting interaction:144-145|mutation decreasing interaction:146-147|mutation decreasing interaction:202-203|his tag:c-c|mutation decreasing interaction:39-41|mutation decreasing interaction:187-188|mutation decreasing interaction:197-198|mutation decreasing interaction:202-203|mutation decreasing interaction:204-205	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:16113"	uniprotkb:O15118	intact:EBI-2368700	intact:EBI-2368710|uniprotkb:Q9P130|uniprotkb:B4DET3|ensembl:ENSP00000269228	psi-mi:cholesterol(display_short)|psi-mi:"CHEBI:16113"(display_long)	psi-mi:npc1_human(display_long)|uniprotkb:NPC1(gene name)|psi-mi:NPC1(display_short)|uniprotkb:Niemann-Pick C1 protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Kwon et al. (2009)	pubmed:19563754|imex:IM-20332	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2368970|wwpdb:3GKI|imex:IM-20332-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0919"(acceptor)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_000262.2|dip:DIP-53217N|ensembl:ENSG00000141458(gene)|ensembl:ENST00000269228(transcript)|go:"GO:0001618"(virus receptor activity)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006486"(protein glycosylation)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0007041"(lysosomal transport)|go:"GO:0007628"(adult walking behavior)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0008206"(bile acid metabolic process)|go:"GO:0010467"(gene expression)|go:"GO:0015248"(sterol transporter activity)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016242"(negative regulation of macroautophagy)|go:"GO:0030301"(cholesterol transport)|go:"GO:0031579"(membrane raft organization)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032367"(intracellular cholesterol transport)|go:"GO:0033344"(cholesterol efflux)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042493"|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0045121"(membrane raft)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071383"(cellular response to steroid hormone stimulus)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0090150"(establishment of protein localization to membrane)|go:"GO:1905103"(integral component of lysosomal membrane)|interpro:IPR000731(Sterol-sensing 5TM box)|interpro:IPR003392(Patched)|interpro:IPR004765(Niemann-Pick C type protein)|interpro:IPR032190|rcsb pdb:3GKH|rcsb pdb:3GKI|rcsb pdb:3GKJ|rcsb pdb:3JD8|rcsb pdb:5F18|rcsb pdb:5F1B|rcsb pdb:5HNS|rcsb pdb:5JNX|rcsb pdb:5KWY|rcsb pdb:5U73|rcsb pdb:5U74|rcsb pdb:6UOX|rcsb pdb:6W5R|rcsb pdb:6W5S|rcsb pdb:6W5T|rcsb pdb:6W5U|rcsb pdb:6W5V|reactome:R-HSA-8964038	go:"GO:0015485"(cholesterol binding)	-	-	figure legend:Fig. 5D|comment:Cholesterol is [3H] radio-labelled.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/07/23	2014/10/16	-	rogid:3kG4MGzeShC2D5FsPoZZm1lEGlk9606	intact-crc:4B6B1D13BDAA9E71	false	-	sufficient binding region:23-252|mutation decreasing interaction:175-176|his tag:c-c	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:16113"	uniprotkb:P61916	intact:EBI-2368700	intact:EBI-2368946|uniprotkb:Q15668|uniprotkb:Q29413|uniprotkb:B4DQV7|ensembl:ENSP00000451112	psi-mi:cholesterol(display_short)|psi-mi:"CHEBI:16113"(display_long)	psi-mi:npc2_human(display_long)|uniprotkb:NPC2(gene name)|psi-mi:NPC2(display_short)|uniprotkb:Niemann-Pick disease type C2 protein(gene name synonym)|uniprotkb:HE1(gene name synonym)|uniprotkb:Human epididymis-specific protein 1(gene name synonym)|uniprotkb:Epididymal secretory protein E1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Kwon et al. (2009)	pubmed:19563754|imex:IM-20332	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2368970|wwpdb:3GKI|imex:IM-20332-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0918"(donor)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_006423.1|ensembl:ENSG00000119655(gene)|ensembl:ENST00000555619(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005764"(lysosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0009615"(response to virus)|go:"GO:0015485"(cholesterol binding)|go:"GO:0015914"(phospholipid transport)|go:"GO:0015918"(sterol transport)|go:"GO:0019747"(regulation of isoprenoid metabolic process)|go:"GO:0019899"(enzyme binding)|go:"GO:0030301"(cholesterol transport)|go:"GO:0032366"(intracellular sterol transport)|go:"GO:0032367"(intracellular cholesterol transport)|go:"GO:0032934"(sterol binding)|go:"GO:0033344"(cholesterol efflux)|go:"GO:0035578"(azurophil granule lumen)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043202"(lysosomal lumen)|go:"GO:0046836"(glycolipid transport)|go:"GO:0070062"(extracellular exosome)|go:"GO:0120020"(cholesterol transfer activity)|interpro:IPR003172(MD-2-related lipid-recognition)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR033916|interpro:IPR039670|mint:P61916|rcsb pdb:5KWY|rcsb pdb:6W5V|reactome:R-HSA-6798695|reactome:R-HSA-8964038	go:"GO:0015485"(cholesterol binding)	-	-	figure legend:Fig. 5D|comment:Cholesterol is [3H] radio-labelled.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/07/23	2014/10/16	-	rogid:v1WSWKL+SaMlpcVh7Qhespo84Lg9606	intact-crc:4B6B1D13BDAA9E71	false	-	flag tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)