#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P70340	uniprotkb:Q62073	intact:EBI-6992047|ensembl:ENSMUSP00000071035|uniprotkb:Q6GT95|uniprotkb:P70442|uniprotkb:Q9CYK6|intact:MINT-99213	intact:EBI-1775345|ensembl:ENSMUSP00000079734	psi-mi:smad1_mouse(display_long)|uniprotkb:Smad1(gene name)|psi-mi:Smad1(display_short)|uniprotkb:Madh1(gene name synonym)|uniprotkb:Madr1(gene name synonym)|uniprotkb:Mothers-against-DPP-related 1(gene name synonym)|uniprotkb:Dwarfin-A(gene name synonym)|uniprotkb:SMAD family member 1(gene name synonym)	psi-mi:m3k7_mouse(display_long)|uniprotkb:Map3k7(gene name)|psi-mi:Map3k7(display_short)|uniprotkb:Tak1(gene name synonym)|uniprotkb:Transforming growth factor-beta-activated kinase 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Shim et al. (2009)	pubmed:19536134|imex:IM-14126|mint:MINT-7296621|doi:10.1038/emboj.2009.162	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7066460|mint:MINT-7296641|imex:IM-14126-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006530809.1|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0017151"(DEAD/H-box RNA helicase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030901"(midbrain development)|go:"GO:0006954"(inflammatory response)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0030902"(hindbrain development)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042493"|go:"GO:0042592"(homeostatic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0051216"(cartilage development)|go:"GO:0060038"(cardiac muscle cell proliferation)|go:"GO:0060348"(bone development)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0007276"(gamete generation)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0070410"(co-SMAD binding)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|mint:P70340|rcsb pdb:3KMP|reactome:R-MMU-201451|reactome:R-MMU-5689880|reactome:R-MMU-8941326|ensembl:ENSMUSG00000031681(gene)|ensembl:ENSMUST00000066091(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0002051"(osteoblast fate commitment)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006468"(protein phosphorylation)|refseq:NP_032565.2|mint:MINT-7296644(identity)	refseq:NP_766276.1|dip:DIP-40666N|ensembl:ENSMUSG00000028284(gene)|ensembl:ENSMUST00000080933(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001525"(angiogenesis)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001841"(neural tube formation)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0007254"(JNK cascade)|go:"GO:0008349"(MAP kinase kinase kinase kinase activity)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019211"(phosphatase activator activity)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043276"(anoikis)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0060348"(bone development)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0140537"(transcription regulator activator activity)|go:"GO:1902443"(negative regulation of ripoptosome assembly involved in necroptotic process)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017421(Mitogen-activated protein kinase kinase kinase 7)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q62073|reactome:R-MMU-168638|reactome:R-MMU-202424|reactome:R-MMU-2871837|reactome:R-MMU-4086398|reactome:R-MMU-445989|reactome:R-MMU-450302|reactome:R-MMU-450321|reactome:R-MMU-5357956|reactome:R-MMU-5607764|reactome:R-MMU-5689880|reactome:R-MMU-9020702|reactome:R-MMU-937042|reactome:R-MMU-937072|reactome:R-MMU-9645460|reactome:R-MMU-975163|mint:MINT-7296643(identity)	-	comment:mint|function:"Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD1 is a receptor-regulated SMAD (R-SMAD) (By similarity). May play a role in the initiation and maintenance of spermatogenesis"	-	comment:homomint|comment:mint|figure legend:5a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/11/05	2014/10/16	rogid:D3Mhh31YZUsykSUfzewNuy8NyrY10090	rogid:2S6IUyXZT5QqsQ4SAIpIJszQuPE10090	intact-crc:B7F53761B81A890B|rigid:EDivat5fTK2gGhKNRtzRhF2TXMM	false	flag tag:?-?(MINT-7296667)	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q9JIW5	uniprotkb:Q62073	intact:EBI-7066560|ensembl:ENSMUSP00000029371|intact:UNK-5549008|uniprotkb:Q8CFF9	intact:EBI-1775345|ensembl:ENSMUSP00000079734	psi-mi:smad9_mouse(display_long)|uniprotkb:Smad9(gene name)|psi-mi:Smad9(display_short)|uniprotkb:Madh8(gene name synonym)|uniprotkb:Madh9(gene name synonym)|uniprotkb:Smad8(gene name synonym)|uniprotkb:SMAD family member 9(gene name synonym)	psi-mi:m3k7_mouse(display_long)|uniprotkb:Map3k7(gene name)|psi-mi:Map3k7(display_short)|uniprotkb:Tak1(gene name synonym)|uniprotkb:Transforming growth factor-beta-activated kinase 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Shim et al. (2009)	pubmed:19536134|imex:IM-14126|mint:MINT-7296621|doi:10.1038/emboj.2009.162	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7066553|mint:MINT-7296695|imex:IM-14126-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006501791.1|ensembl:ENSMUSG00000027796(gene)|ensembl:ENSMUST00000029371(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001880"(Mullerian duct regression)|go:"GO:0005634"(nucleus)|go:"GO:0046872"(metal ion binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0051216"(cartilage development)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0060348"(bone development)|go:"GO:0030154"(cell differentiation)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030901"(midbrain development)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0071407"(cellular response to organic cyclic compound)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|go:"GO:0030902"(hindbrain development)|interpro:IPR036578|mint:Q9JIW5|reactome:R-MMU-201451|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|refseq:NP_062356.3|mint:MINT-7296697(identity)	refseq:NP_766276.1|dip:DIP-40666N|ensembl:ENSMUSG00000028284(gene)|ensembl:ENSMUST00000080933(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001525"(angiogenesis)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001841"(neural tube formation)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0007254"(JNK cascade)|go:"GO:0008349"(MAP kinase kinase kinase kinase activity)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019211"(phosphatase activator activity)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043276"(anoikis)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0060348"(bone development)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0140537"(transcription regulator activator activity)|go:"GO:1902443"(negative regulation of ripoptosome assembly involved in necroptotic process)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017421(Mitogen-activated protein kinase kinase kinase 7)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q62073|reactome:R-MMU-168638|reactome:R-MMU-202424|reactome:R-MMU-2871837|reactome:R-MMU-4086398|reactome:R-MMU-445989|reactome:R-MMU-450302|reactome:R-MMU-450321|reactome:R-MMU-5357956|reactome:R-MMU-5607764|reactome:R-MMU-5689880|reactome:R-MMU-9020702|reactome:R-MMU-937042|reactome:R-MMU-937072|reactome:R-MMU-9645460|reactome:R-MMU-975163|mint:MINT-7296701(identity)	-	comment:mint|function:"Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD9 is a receptor-regulated SMAD (R-SMAD). Has been shown to be activated by activin type I receptor-like kinases (ALK-2, ALK-3, ALK-6) which stimulate heteromerization between SMAD9 and SMAD4. May play a role in osteoblast differentiation and maturation"	-	comment:homomint|comment:mint|figure legend:5a|comment:proteins taxid has not been specified|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/11/05	2014/10/16	rogid:PiYLEGhx/K6hFtpswhqD1DbruD010090	rogid:2S6IUyXZT5QqsQ4SAIpIJszQuPE10090	intact-crc:10ED6B2B427A38C9|rigid:K/bteegt9pYE2qjq1SuZPmO9V0Y	false	flag tag:?-?(MINT-7296698)	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:P97454	uniprotkb:Q62073	intact:EBI-7066475|ensembl:ENSMUSP00000065798|ensembl:ENSMUSP00000105500|ensembl:ENSMUSP00000105502|uniprotkb:P70341|intact:MINT-99279|uniprotkb:Q810K0	intact:EBI-1775345|ensembl:ENSMUSP00000079734	psi-mi:smad5_mouse(display_long)|uniprotkb:Smad5(gene name)|psi-mi:Smad5(display_short)|uniprotkb:Madh5(gene name synonym)|uniprotkb:Msmad5(gene name synonym)|uniprotkb:SMAD family member 5(gene name synonym)|uniprotkb:Dwarfin-C(gene name synonym)	psi-mi:m3k7_mouse(display_long)|uniprotkb:Map3k7(gene name)|psi-mi:Map3k7(display_short)|uniprotkb:Tak1(gene name synonym)|uniprotkb:Transforming growth factor-beta-activated kinase 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Shim et al. (2009)	pubmed:19536134|imex:IM-14126|mint:MINT-7296621|doi:10.1038/emboj.2009.162	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7066523|mint:MINT-7296673|imex:IM-14126-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006517180.1|refseq:XP_006517181.1|ensembl:ENSMUSG00000021540(gene)|ensembl:ENSMUST00000069557(transcript)|ensembl:ENSMUST00000109874(transcript)|ensembl:ENSMUST00000109876(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001880"(Mullerian duct regression)|go:"GO:0002051"(osteoblast fate commitment)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007281"(germ cell development)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0017151"(DEAD/H-box RNA helicase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0051216"(cartilage development)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060348"(bone development)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|mint:P97454|rcsb pdb:5X6G|rcsb pdb:5X6H|rcsb pdb:5X6M|reactome:R-MMU-201451|refseq:NP_001157513.1|refseq:NP_032567.1|refseq:NP_001157514.1|mint:MINT-7296675(identity)	refseq:NP_766276.1|dip:DIP-40666N|ensembl:ENSMUSG00000028284(gene)|ensembl:ENSMUST00000080933(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001525"(angiogenesis)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001841"(neural tube formation)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0007254"(JNK cascade)|go:"GO:0008349"(MAP kinase kinase kinase kinase activity)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019211"(phosphatase activator activity)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043276"(anoikis)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0060348"(bone development)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0140537"(transcription regulator activator activity)|go:"GO:1902443"(negative regulation of ripoptosome assembly involved in necroptotic process)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017421(Mitogen-activated protein kinase kinase kinase 7)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q62073|reactome:R-MMU-168638|reactome:R-MMU-202424|reactome:R-MMU-2871837|reactome:R-MMU-4086398|reactome:R-MMU-445989|reactome:R-MMU-450302|reactome:R-MMU-450321|reactome:R-MMU-5357956|reactome:R-MMU-5607764|reactome:R-MMU-5689880|reactome:R-MMU-9020702|reactome:R-MMU-937042|reactome:R-MMU-937072|reactome:R-MMU-9645460|reactome:R-MMU-975163|mint:MINT-7296679(identity)	-	comment:mint|function:"Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD5 is a receptor-regulated SMAD (R-SMAD) (By similarity). Required for angiogenesis"	-	comment:mint|figure legend:5a|comment:proteins taxid has not been specified|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/11/05	2014/10/16	rogid:9+0xdGWH0UtFQl/ec5ybRhFyHXQ10090	rogid:2S6IUyXZT5QqsQ4SAIpIJszQuPE10090	intact-crc:F9401ACB73B1B241|rigid:ejqPbi2Zgwilu4ChL3k/WZyXj24	false	flag tag:?-?(MINT-7296676)	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:P70340	uniprotkb:Q62073	intact:EBI-6992047|ensembl:ENSMUSP00000071035|uniprotkb:Q6GT95|uniprotkb:P70442|uniprotkb:Q9CYK6|intact:MINT-99213	intact:EBI-1775345|ensembl:ENSMUSP00000079734	psi-mi:smad1_mouse(display_long)|uniprotkb:Smad1(gene name)|psi-mi:Smad1(display_short)|uniprotkb:Madh1(gene name synonym)|uniprotkb:Madr1(gene name synonym)|uniprotkb:Mothers-against-DPP-related 1(gene name synonym)|uniprotkb:Dwarfin-A(gene name synonym)|uniprotkb:SMAD family member 1(gene name synonym)	psi-mi:m3k7_mouse(display_long)|uniprotkb:Map3k7(gene name)|psi-mi:Map3k7(display_short)|uniprotkb:Tak1(gene name synonym)|uniprotkb:Transforming growth factor-beta-activated kinase 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Shim et al. (2009)	pubmed:19536134|imex:IM-14126|mint:MINT-7296621|doi:10.1038/emboj.2009.162	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7066610|mint:MINT-7296722|imex:IM-14126-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006530809.1|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0017151"(DEAD/H-box RNA helicase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030901"(midbrain development)|go:"GO:0006954"(inflammatory response)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0030902"(hindbrain development)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042493"|go:"GO:0042592"(homeostatic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0051216"(cartilage development)|go:"GO:0060038"(cardiac muscle cell proliferation)|go:"GO:0060348"(bone development)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0007276"(gamete generation)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0070410"(co-SMAD binding)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|mint:P70340|rcsb pdb:3KMP|reactome:R-MMU-201451|reactome:R-MMU-5689880|reactome:R-MMU-8941326|ensembl:ENSMUSG00000031681(gene)|ensembl:ENSMUST00000066091(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0002051"(osteoblast fate commitment)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006468"(protein phosphorylation)|refseq:NP_032565.2|mint:MINT-7296724(identity)	refseq:NP_766276.1|dip:DIP-40666N|ensembl:ENSMUSG00000028284(gene)|ensembl:ENSMUST00000080933(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001525"(angiogenesis)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001841"(neural tube formation)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0007254"(JNK cascade)|go:"GO:0008349"(MAP kinase kinase kinase kinase activity)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019211"(phosphatase activator activity)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043276"(anoikis)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0060348"(bone development)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0140537"(transcription regulator activator activity)|go:"GO:1902443"(negative regulation of ripoptosome assembly involved in necroptotic process)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017421(Mitogen-activated protein kinase kinase kinase 7)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q62073|reactome:R-MMU-168638|reactome:R-MMU-202424|reactome:R-MMU-2871837|reactome:R-MMU-4086398|reactome:R-MMU-445989|reactome:R-MMU-450302|reactome:R-MMU-450321|reactome:R-MMU-5357956|reactome:R-MMU-5607764|reactome:R-MMU-5689880|reactome:R-MMU-9020702|reactome:R-MMU-937042|reactome:R-MMU-937072|reactome:R-MMU-9645460|reactome:R-MMU-975163|mint:MINT-7296728(identity)	-	comment:mint|function:"Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD1 is a receptor-regulated SMAD (R-SMAD) (By similarity). May play a role in the initiation and maintenance of spermatogenesis"	-	comment:homomint|comment:mint|figure legend:5a|comment:proteins taxid has not been specified|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/11/05	2014/10/16	rogid:D3Mhh31YZUsykSUfzewNuy8NyrY10090	rogid:2S6IUyXZT5QqsQ4SAIpIJszQuPE10090	intact-crc:894E6B5393566ABE|rigid:EDivat5fTK2gGhKNRtzRhF2TXMM	false	glutathione s tranferase tag:?-?(MINT-7296725)	-	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:P70340	uniprotkb:Q62073	intact:EBI-6992047|ensembl:ENSMUSP00000071035|uniprotkb:Q6GT95|uniprotkb:P70442|uniprotkb:Q9CYK6|intact:MINT-99213	intact:EBI-1775345|ensembl:ENSMUSP00000079734	psi-mi:smad1_mouse(display_long)|uniprotkb:Smad1(gene name)|psi-mi:Smad1(display_short)|uniprotkb:Madh1(gene name synonym)|uniprotkb:Madr1(gene name synonym)|uniprotkb:Mothers-against-DPP-related 1(gene name synonym)|uniprotkb:Dwarfin-A(gene name synonym)|uniprotkb:SMAD family member 1(gene name synonym)	psi-mi:m3k7_mouse(display_long)|uniprotkb:Map3k7(gene name)|psi-mi:Map3k7(display_short)|uniprotkb:Tak1(gene name synonym)|uniprotkb:Transforming growth factor-beta-activated kinase 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Shim et al. (2009)	pubmed:19536134|imex:IM-14126|mint:MINT-7296621|doi:10.1038/emboj.2009.162	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7066635|mint:MINT-7296734|imex:IM-14126-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006530809.1|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0017151"(DEAD/H-box RNA helicase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030901"(midbrain development)|go:"GO:0006954"(inflammatory response)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0030902"(hindbrain development)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042493"|go:"GO:0042592"(homeostatic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0051216"(cartilage development)|go:"GO:0060038"(cardiac muscle cell proliferation)|go:"GO:0060348"(bone development)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0007276"(gamete generation)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0070410"(co-SMAD binding)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|mint:P70340|rcsb pdb:3KMP|reactome:R-MMU-201451|reactome:R-MMU-5689880|reactome:R-MMU-8941326|ensembl:ENSMUSG00000031681(gene)|ensembl:ENSMUST00000066091(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0002051"(osteoblast fate commitment)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006468"(protein phosphorylation)|refseq:NP_032565.2|mint:MINT-7296736(identity)	refseq:NP_766276.1|dip:DIP-40666N|ensembl:ENSMUSG00000028284(gene)|ensembl:ENSMUST00000080933(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001525"(angiogenesis)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001841"(neural tube formation)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0007254"(JNK cascade)|go:"GO:0008349"(MAP kinase kinase kinase kinase activity)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019211"(phosphatase activator activity)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043276"(anoikis)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0060348"(bone development)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0140537"(transcription regulator activator activity)|go:"GO:1902443"(negative regulation of ripoptosome assembly involved in necroptotic process)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017421(Mitogen-activated protein kinase kinase kinase 7)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q62073|reactome:R-MMU-168638|reactome:R-MMU-202424|reactome:R-MMU-2871837|reactome:R-MMU-4086398|reactome:R-MMU-445989|reactome:R-MMU-450302|reactome:R-MMU-450321|reactome:R-MMU-5357956|reactome:R-MMU-5607764|reactome:R-MMU-5689880|reactome:R-MMU-9020702|reactome:R-MMU-937042|reactome:R-MMU-937072|reactome:R-MMU-9645460|reactome:R-MMU-975163|mint:MINT-7296740(identity)	-	comment:mint|function:"Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD1 is a receptor-regulated SMAD (R-SMAD) (By similarity). May play a role in the initiation and maintenance of spermatogenesis"	-	comment:homomint|comment:mint|figure legend:5b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-chondrocytes)|taxid:10090(Mus musculus)	-	2009/11/05	2014/10/16	rogid:D3Mhh31YZUsykSUfzewNuy8NyrY10090	rogid:2S6IUyXZT5QqsQ4SAIpIJszQuPE10090	intact-crc:DDA4F0E24D3E4542|rigid:EDivat5fTK2gGhKNRtzRhF2TXMM	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)