#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P04273	uniprotkb:Q9D074	intact:EBI-986426	intact:EBI-2368450|uniprotkb:Q3U5V9|uniprotkb:Q3UDA1|uniprotkb:Q6ZQ97|uniprotkb:Q8BZM9|ensembl:ENSMUSP00000068314	psi-mi:prio_mesau(display_long)|uniprotkb:PrP27-30(gene name synonym)|uniprotkb:PrP33-35C(gene name synonym)|uniprotkb:PRNP(gene name)|psi-mi:PRNP(display_short)|uniprotkb:PRP(gene name synonym)	psi-mi:mgrn1_mouse(display_long)|uniprotkb:Mgrn1(gene name)|psi-mi:Mgrn1(display_short)|uniprotkb:Kiaa0544(gene name synonym)|uniprotkb:Mahogunin RING finger protein 1(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase MGRN1(gene name synonym)	psi-mi:"MI:0400"(affinity technology)	Chakrabarti et al. (2009)	imex:IM-12197|pubmed:19524515	taxid:10036(mesau)|taxid:10036("Mesocricetus auratus (Golden hamster)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2368444|imex:IM-12197-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005539"(glycosaminoglycan binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007049"(cell cycle)|go:"GO:0007611"(learning or memory)|go:"GO:0008017"(microtubule binding)|go:"GO:0009986"(cell surface)|go:"GO:0016234"(inclusion body)|go:"GO:0019828"(aspartic-type endopeptidase inhibitor activity)|go:"GO:0030425"(dendrite)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0031648"(protein destabilization)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032700"(negative regulation of interleukin-17 production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0035690"|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:1900449"(regulation of glutamate receptor signaling pathway)|go:"GO:1901379"(regulation of potassium ion transmembrane transport)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|rcsb pdb:1B10|rcsb pdb:2KKG|rcsb pdb:2LH8|rcsb pdb:3NVE|rcsb pdb:4YXL|go:"GO:1902938"(regulation of intracellular calcium activated chloride channel activity)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903135"(cupric ion binding)|go:"GO:1903136"(cuprous ion binding)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905664"(regulation of calcium ion import across plasma membrane)|go:"GO:1990535"(neuron projection maintenance)|interpro:IPR000817(Prion protein)|interpro:IPR022416|interpro:IPR025860|interpro:IPR036924|refseq:XP_005068717.1|refseq:XP_012967855.1|dip:DIP-1081N	refseq:XP_017172376.1|refseq:NP_083933.1|refseq:XP_006521895.1|refseq:XP_006521897.1|refseq:NP_001239366.1|ensembl:ENSMUSG00000022517(gene)|ensembl:ENSMUST00000070658(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043951"(negative regulation of cAMP-mediated signaling)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|reactome:R-MMU-983168	psi-mi:"MI:0469"(intact)	-	-	figure legend:Figs. 1C, Supp. Fig. 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-n2a)|taxid:10090(Mouse neuroblastoma cells)	-	2009/07/23	2014/10/16	rogid:Y/37yOYTc1NpikBNqi9Az1BwaAE10036	rogid:wpa50EEoj+2YLk7xUkABnzHy7gA10090	intact-crc:05B4C31DBAC66101|rigid:+aoBSYRETeZnbpnWwhC+pjhYn4I	false	sufficient binding region:40-231|cyan fluorescent protein tag:?-?	red fluorescent protein tag:?-?	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:Q9D074	uniprotkb:P04273	intact:EBI-2368450|uniprotkb:Q3U5V9|uniprotkb:Q3UDA1|uniprotkb:Q6ZQ97|uniprotkb:Q8BZM9|ensembl:ENSMUSP00000068314	intact:EBI-986426	psi-mi:mgrn1_mouse(display_long)|uniprotkb:Mgrn1(gene name)|psi-mi:Mgrn1(display_short)|uniprotkb:Kiaa0544(gene name synonym)|uniprotkb:Mahogunin RING finger protein 1(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase MGRN1(gene name synonym)	psi-mi:prio_mesau(display_long)|uniprotkb:PrP27-30(gene name synonym)|uniprotkb:PrP33-35C(gene name synonym)|uniprotkb:PRNP(gene name)|psi-mi:PRNP(display_short)|uniprotkb:PRP(gene name synonym)	psi-mi:"MI:0400"(affinity technology)	Chakrabarti et al. (2009)	imex:IM-12197|pubmed:19524515	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10036(mesau)|taxid:10036("Mesocricetus auratus (Golden hamster)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2368491|imex:IM-12197-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_017172376.1|refseq:NP_083933.1|refseq:XP_006521895.1|refseq:XP_006521897.1|refseq:NP_001239366.1|ensembl:ENSMUSG00000022517(gene)|ensembl:ENSMUST00000070658(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043951"(negative regulation of cAMP-mediated signaling)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|reactome:R-MMU-983168	go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005539"(glycosaminoglycan binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007049"(cell cycle)|go:"GO:0007611"(learning or memory)|go:"GO:0008017"(microtubule binding)|go:"GO:0009986"(cell surface)|go:"GO:0016234"(inclusion body)|go:"GO:0019828"(aspartic-type endopeptidase inhibitor activity)|go:"GO:0030425"(dendrite)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0031648"(protein destabilization)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032700"(negative regulation of interleukin-17 production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0035690"|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:1900449"(regulation of glutamate receptor signaling pathway)|go:"GO:1901379"(regulation of potassium ion transmembrane transport)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|rcsb pdb:1B10|rcsb pdb:2KKG|rcsb pdb:2LH8|rcsb pdb:3NVE|rcsb pdb:4YXL|go:"GO:1902938"(regulation of intracellular calcium activated chloride channel activity)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903135"(cupric ion binding)|go:"GO:1903136"(cuprous ion binding)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905664"(regulation of calcium ion import across plasma membrane)|go:"GO:1990535"(neuron projection maintenance)|interpro:IPR000817(Prion protein)|interpro:IPR022416|interpro:IPR025860|interpro:IPR036924|refseq:XP_005068717.1|refseq:XP_012967855.1|dip:DIP-1081N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Figs. 1E|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-n2a)|taxid:10090(Mouse neuroblastoma cells)	-	2009/07/23	2014/10/16	rogid:wpa50EEoj+2YLk7xUkABnzHy7gA10090	rogid:Y/37yOYTc1NpikBNqi9Az1BwaAE10036	intact-crc:D42F05190C0C6DB4|rigid:+aoBSYRETeZnbpnWwhC+pjhYn4I	false	red fluorescent protein tag:?-?	sufficient binding region:105-231|cyan fluorescent protein tag:?-?|experimental feature:118-134	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:Q9D074	uniprotkb:P04273	intact:EBI-2368450|uniprotkb:Q3U5V9|uniprotkb:Q3UDA1|uniprotkb:Q6ZQ97|uniprotkb:Q8BZM9|ensembl:ENSMUSP00000068314	intact:EBI-986426	psi-mi:mgrn1_mouse(display_long)|uniprotkb:Mgrn1(gene name)|psi-mi:Mgrn1(display_short)|uniprotkb:Kiaa0544(gene name synonym)|uniprotkb:Mahogunin RING finger protein 1(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase MGRN1(gene name synonym)	psi-mi:prio_mesau(display_long)|uniprotkb:PrP27-30(gene name synonym)|uniprotkb:PrP33-35C(gene name synonym)|uniprotkb:PRNP(gene name)|psi-mi:PRNP(display_short)|uniprotkb:PRP(gene name synonym)	psi-mi:"MI:0400"(affinity technology)	Chakrabarti et al. (2009)	imex:IM-12197|pubmed:19524515	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10036(mesau)|taxid:10036("Mesocricetus auratus (Golden hamster)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2368519|imex:IM-12197-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_017172376.1|refseq:NP_083933.1|refseq:XP_006521895.1|refseq:XP_006521897.1|refseq:NP_001239366.1|ensembl:ENSMUSG00000022517(gene)|ensembl:ENSMUST00000070658(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043951"(negative regulation of cAMP-mediated signaling)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|reactome:R-MMU-983168	go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005539"(glycosaminoglycan binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007049"(cell cycle)|go:"GO:0007611"(learning or memory)|go:"GO:0008017"(microtubule binding)|go:"GO:0009986"(cell surface)|go:"GO:0016234"(inclusion body)|go:"GO:0019828"(aspartic-type endopeptidase inhibitor activity)|go:"GO:0030425"(dendrite)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0031648"(protein destabilization)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032700"(negative regulation of interleukin-17 production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0035690"|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:1900449"(regulation of glutamate receptor signaling pathway)|go:"GO:1901379"(regulation of potassium ion transmembrane transport)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|rcsb pdb:1B10|rcsb pdb:2KKG|rcsb pdb:2LH8|rcsb pdb:3NVE|rcsb pdb:4YXL|go:"GO:1902938"(regulation of intracellular calcium activated chloride channel activity)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903135"(cupric ion binding)|go:"GO:1903136"(cuprous ion binding)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905664"(regulation of calcium ion import across plasma membrane)|go:"GO:1990535"(neuron projection maintenance)|interpro:IPR000817(Prion protein)|interpro:IPR022416|interpro:IPR025860|interpro:IPR036924|refseq:XP_005068717.1|refseq:XP_012967855.1|dip:DIP-1081N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 2A, Supp. Fig 4A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-n2a)|taxid:10090(Mouse neuroblastoma cells)	-	2009/07/23	2014/10/16	rogid:wpa50EEoj+2YLk7xUkABnzHy7gA10090	rogid:Y/37yOYTc1NpikBNqi9Az1BwaAE10036	intact-crc:30F6A7C7FC73F9C4|rigid:+aoBSYRETeZnbpnWwhC+pjhYn4I	false	green fluorescent protein tag:?-?|necessary binding region:199-251	sufficient binding region:40-231	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:P04273	uniprotkb:Q9D074	intact:EBI-986426	intact:EBI-2368450|uniprotkb:Q3U5V9|uniprotkb:Q3UDA1|uniprotkb:Q6ZQ97|uniprotkb:Q8BZM9|ensembl:ENSMUSP00000068314	psi-mi:prio_mesau(display_long)|uniprotkb:PrP27-30(gene name synonym)|uniprotkb:PrP33-35C(gene name synonym)|uniprotkb:PRNP(gene name)|psi-mi:PRNP(display_short)|uniprotkb:PRP(gene name synonym)	psi-mi:mgrn1_mouse(display_long)|uniprotkb:Mgrn1(gene name)|psi-mi:Mgrn1(display_short)|uniprotkb:Kiaa0544(gene name synonym)|uniprotkb:Mahogunin RING finger protein 1(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase MGRN1(gene name synonym)	psi-mi:"MI:0400"(affinity technology)	Chakrabarti et al. (2009)	imex:IM-12197|pubmed:19524515	taxid:10036(mesau)|taxid:10036("Mesocricetus auratus (Golden hamster)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2368530|imex:IM-12197-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005539"(glycosaminoglycan binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007049"(cell cycle)|go:"GO:0007611"(learning or memory)|go:"GO:0008017"(microtubule binding)|go:"GO:0009986"(cell surface)|go:"GO:0016234"(inclusion body)|go:"GO:0019828"(aspartic-type endopeptidase inhibitor activity)|go:"GO:0030425"(dendrite)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0031648"(protein destabilization)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032700"(negative regulation of interleukin-17 production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0035690"|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:1900449"(regulation of glutamate receptor signaling pathway)|go:"GO:1901379"(regulation of potassium ion transmembrane transport)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|rcsb pdb:1B10|rcsb pdb:2KKG|rcsb pdb:2LH8|rcsb pdb:3NVE|rcsb pdb:4YXL|go:"GO:1902938"(regulation of intracellular calcium activated chloride channel activity)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903135"(cupric ion binding)|go:"GO:1903136"(cuprous ion binding)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905664"(regulation of calcium ion import across plasma membrane)|go:"GO:1990535"(neuron projection maintenance)|interpro:IPR000817(Prion protein)|interpro:IPR022416|interpro:IPR025860|interpro:IPR036924|refseq:XP_005068717.1|refseq:XP_012967855.1|dip:DIP-1081N	refseq:XP_017172376.1|refseq:NP_083933.1|refseq:XP_006521895.1|refseq:XP_006521897.1|refseq:NP_001239366.1|ensembl:ENSMUSG00000022517(gene)|ensembl:ENSMUST00000070658(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043951"(negative regulation of cAMP-mediated signaling)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|reactome:R-MMU-983168	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 2A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-n2a)|taxid:10090(Mouse neuroblastoma cells)	-	2009/07/23	2014/10/16	rogid:Y/37yOYTc1NpikBNqi9Az1BwaAE10036	rogid:wpa50EEoj+2YLk7xUkABnzHy7gA10090	intact-crc:90223B18376BF41F|rigid:+aoBSYRETeZnbpnWwhC+pjhYn4I	false	necessary binding region:84-95|green fluorescent protein tag:?-?	red fluorescent protein tag:?-?	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
uniprotkb:P04273	uniprotkb:Q9D074	intact:EBI-986426	intact:EBI-2368450|uniprotkb:Q3U5V9|uniprotkb:Q3UDA1|uniprotkb:Q6ZQ97|uniprotkb:Q8BZM9|ensembl:ENSMUSP00000068314	psi-mi:prio_mesau(display_long)|uniprotkb:PrP27-30(gene name synonym)|uniprotkb:PrP33-35C(gene name synonym)|uniprotkb:PRNP(gene name)|psi-mi:PRNP(display_short)|uniprotkb:PRP(gene name synonym)	psi-mi:mgrn1_mouse(display_long)|uniprotkb:Mgrn1(gene name)|psi-mi:Mgrn1(display_short)|uniprotkb:Kiaa0544(gene name synonym)|uniprotkb:Mahogunin RING finger protein 1(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase MGRN1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Chakrabarti et al. (2009)	imex:IM-12197|pubmed:19524515	taxid:10036(mesau)|taxid:10036("Mesocricetus auratus (Golden hamster)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2368511|imex:IM-12197-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005539"(glycosaminoglycan binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007049"(cell cycle)|go:"GO:0007611"(learning or memory)|go:"GO:0008017"(microtubule binding)|go:"GO:0009986"(cell surface)|go:"GO:0016234"(inclusion body)|go:"GO:0019828"(aspartic-type endopeptidase inhibitor activity)|go:"GO:0030425"(dendrite)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0031648"(protein destabilization)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032700"(negative regulation of interleukin-17 production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0035690"|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:1900449"(regulation of glutamate receptor signaling pathway)|go:"GO:1901379"(regulation of potassium ion transmembrane transport)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|rcsb pdb:1B10|rcsb pdb:2KKG|rcsb pdb:2LH8|rcsb pdb:3NVE|rcsb pdb:4YXL|go:"GO:1902938"(regulation of intracellular calcium activated chloride channel activity)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903135"(cupric ion binding)|go:"GO:1903136"(cuprous ion binding)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905664"(regulation of calcium ion import across plasma membrane)|go:"GO:1990535"(neuron projection maintenance)|interpro:IPR000817(Prion protein)|interpro:IPR022416|interpro:IPR025860|interpro:IPR036924|refseq:XP_005068717.1|refseq:XP_012967855.1|dip:DIP-1081N	refseq:XP_017172376.1|refseq:NP_083933.1|refseq:XP_006521895.1|refseq:XP_006521897.1|refseq:NP_001239366.1|ensembl:ENSMUSG00000022517(gene)|ensembl:ENSMUST00000070658(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043951"(negative regulation of cAMP-mediated signaling)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|reactome:R-MMU-983168	psi-mi:"MI:0469"(intact)	-	-	figure legend:Figs. 1F|comment:Prnp protein in brain lysate has been assumed to be its mature form.|comment:Bait protein immobilized on CnBr activated sepharose. Expression system for production of recombinant Mgrn1 not given.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/07/23	2014/10/16	rogid:Y/37yOYTc1NpikBNqi9Az1BwaAE10036	rogid:wpa50EEoj+2YLk7xUkABnzHy7gA10090	intact-crc:DDE11525FABF6A79|rigid:+aoBSYRETeZnbpnWwhC+pjhYn4I	false	sufficient binding region:23-231	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9D074	uniprotkb:P04273	intact:EBI-2368450|uniprotkb:Q3U5V9|uniprotkb:Q3UDA1|uniprotkb:Q6ZQ97|uniprotkb:Q8BZM9|ensembl:ENSMUSP00000068314	intact:EBI-986426	psi-mi:mgrn1_mouse(display_long)|uniprotkb:Mgrn1(gene name)|psi-mi:Mgrn1(display_short)|uniprotkb:Kiaa0544(gene name synonym)|uniprotkb:Mahogunin RING finger protein 1(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase MGRN1(gene name synonym)	psi-mi:prio_mesau(display_long)|uniprotkb:PrP27-30(gene name synonym)|uniprotkb:PrP33-35C(gene name synonym)|uniprotkb:PRNP(gene name)|psi-mi:PRNP(display_short)|uniprotkb:PRP(gene name synonym)	psi-mi:"MI:0096"(pull down)	Chakrabarti et al. (2009)	imex:IM-12197|pubmed:19524515	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10036(mesau)|taxid:10036("Mesocricetus auratus (Golden hamster)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2368541|imex:IM-12197-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_017172376.1|refseq:NP_083933.1|refseq:XP_006521895.1|refseq:XP_006521897.1|refseq:NP_001239366.1|ensembl:ENSMUSG00000022517(gene)|ensembl:ENSMUST00000070658(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043951"(negative regulation of cAMP-mediated signaling)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|reactome:R-MMU-983168	go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005539"(glycosaminoglycan binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007049"(cell cycle)|go:"GO:0007611"(learning or memory)|go:"GO:0008017"(microtubule binding)|go:"GO:0009986"(cell surface)|go:"GO:0016234"(inclusion body)|go:"GO:0019828"(aspartic-type endopeptidase inhibitor activity)|go:"GO:0030425"(dendrite)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0031648"(protein destabilization)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032700"(negative regulation of interleukin-17 production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0035690"|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:1900449"(regulation of glutamate receptor signaling pathway)|go:"GO:1901379"(regulation of potassium ion transmembrane transport)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|rcsb pdb:1B10|rcsb pdb:2KKG|rcsb pdb:2LH8|rcsb pdb:3NVE|rcsb pdb:4YXL|go:"GO:1902938"(regulation of intracellular calcium activated chloride channel activity)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903135"(cupric ion binding)|go:"GO:1903136"(cuprous ion binding)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905664"(regulation of calcium ion import across plasma membrane)|go:"GO:1990535"(neuron projection maintenance)|interpro:IPR000817(Prion protein)|interpro:IPR022416|interpro:IPR025860|interpro:IPR036924|refseq:XP_005068717.1|refseq:XP_012967855.1|dip:DIP-1081N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Figs. 2B and 2C|comment:"Synthetic peptide containing the required sequence, followed by three glycines and a cysteine (PHGGGWGQGGGC), was coupled to Sulfo-Link beads."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/07/23	2014/10/16	rogid:wpa50EEoj+2YLk7xUkABnzHy7gA10090	rogid:Y/37yOYTc1NpikBNqi9Az1BwaAE10036	intact-crc:D4B4818394B09D29|rigid:+aoBSYRETeZnbpnWwhC+pjhYn4I	false	necessary binding region:1-251|green fluorescent protein tag:?-?	sufficient binding region:76-83	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9D074	uniprotkb:P04273	intact:EBI-2368450|uniprotkb:Q3U5V9|uniprotkb:Q3UDA1|uniprotkb:Q6ZQ97|uniprotkb:Q8BZM9|ensembl:ENSMUSP00000068314	intact:EBI-986426	psi-mi:mgrn1_mouse(display_long)|uniprotkb:Mgrn1(gene name)|psi-mi:Mgrn1(display_short)|uniprotkb:Kiaa0544(gene name synonym)|uniprotkb:Mahogunin RING finger protein 1(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase MGRN1(gene name synonym)	psi-mi:prio_mesau(display_long)|uniprotkb:PrP27-30(gene name synonym)|uniprotkb:PrP33-35C(gene name synonym)|uniprotkb:PRNP(gene name)|psi-mi:PRNP(display_short)|uniprotkb:PRP(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Chakrabarti et al. (2009)	imex:IM-12197|pubmed:19524515	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10036(mesau)|taxid:10036("Mesocricetus auratus (Golden hamster)")	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2368562|imex:IM-12197-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_017172376.1|refseq:NP_083933.1|refseq:XP_006521895.1|refseq:XP_006521897.1|refseq:NP_001239366.1|ensembl:ENSMUSG00000022517(gene)|ensembl:ENSMUST00000070658(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043951"(negative regulation of cAMP-mediated signaling)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|reactome:R-MMU-983168	go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005539"(glycosaminoglycan binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007049"(cell cycle)|go:"GO:0007611"(learning or memory)|go:"GO:0008017"(microtubule binding)|go:"GO:0009986"(cell surface)|go:"GO:0016234"(inclusion body)|go:"GO:0019828"(aspartic-type endopeptidase inhibitor activity)|go:"GO:0030425"(dendrite)|go:"GO:0031225"(anchored component of membrane)|go:"GO:0031648"(protein destabilization)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032700"(negative regulation of interleukin-17 production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0035690"|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043195"(terminal bouton)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0090647"(modulation of age-related behavioral decline)|go:"GO:1900449"(regulation of glutamate receptor signaling pathway)|go:"GO:1901379"(regulation of potassium ion transmembrane transport)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|rcsb pdb:1B10|rcsb pdb:2KKG|rcsb pdb:2LH8|rcsb pdb:3NVE|rcsb pdb:4YXL|go:"GO:1902938"(regulation of intracellular calcium activated chloride channel activity)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903135"(cupric ion binding)|go:"GO:1903136"(cuprous ion binding)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905664"(regulation of calcium ion import across plasma membrane)|go:"GO:1990535"(neuron projection maintenance)|interpro:IPR000817(Prion protein)|interpro:IPR022416|interpro:IPR025860|interpro:IPR036924|refseq:XP_005068717.1|refseq:XP_012967855.1|dip:DIP-1081N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 3A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2009/07/23	2014/10/16	rogid:wpa50EEoj+2YLk7xUkABnzHy7gA10090	rogid:Y/37yOYTc1NpikBNqi9Az1BwaAE10036	intact-crc:FFE8BA522DBF1120|rigid:+aoBSYRETeZnbpnWwhC+pjhYn4I	false	-	sufficient binding region:40-231|green fluorescent protein tag:?-?	-	-	psi-mi:"MI:0866"(tag visualisation)	psi-mi:"MI:0866"(tag visualisation)