#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:O94813	uniprotkb:O94813	intact:EBI-1236865|uniprotkb:O95710|uniprotkb:Q17RU3|uniprotkb:Q9Y5Q7|uniprotkb:B7ZLR5|uniprotkb:A0A0A6YYB8|ensembl:ENSP00000422591	intact:EBI-1236865|uniprotkb:O95710|uniprotkb:Q17RU3|uniprotkb:Q9Y5Q7|uniprotkb:B7ZLR5|uniprotkb:A0A0A6YYB8|ensembl:ENSP00000422591	psi-mi:slit2_human(display_long)|uniprotkb:SLIT2(gene name)|psi-mi:SLIT2(display_short)|uniprotkb:SLIL3(gene name synonym)	psi-mi:slit2_human(display_long)|uniprotkb:SLIT2(gene name)|psi-mi:SLIT2(display_short)|uniprotkb:SLIL3(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Seiradake et al. (2009)	pubmed:19498462|imex:IM-14115|mint:MINT-7218932|doi:10.1038/embor.2009.95	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7037905|mint:MINT-7218946|imex:IM-14115-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001276064.1|refseq:NP_001276065.1|refseq:NP_004778.1|dip:DIP-38198N|go:"GO:0003184"(pulmonary valve morphogenesis)|go:"GO:0005095"(GTPase inhibitor activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0035385"(Roundabout signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007411"(axon guidance)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008201"(heparin binding)|go:"GO:0009986"(cell surface)|go:"GO:0010593"(negative regulation of lamellipodium assembly)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0014912"(negative regulation of smooth muscle cell migration)|go:"GO:0016020"(membrane)|go:"GO:0021836"(chemorepulsion involved in postnatal olfactory bulb interneuron migration)|go:"GO:0021972"(corticospinal neuron axon guidance through spinal cord)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030837"(negative regulation of actin filament polymerization)|go:"GO:0031290"(retinal ganglion cell axon guidance)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043116"(negative regulation of vascular permeability)|go:"GO:0043237"(laminin-1 binding)|go:"GO:0043394"(proteoglycan binding)|go:"GO:0048495"(Roundabout binding)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0048846"(axon extension involved in axon guidance)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050919"(negative chemotaxis)|go:"GO:0050929"(induction of negative chemotaxis)|go:"GO:0051058"(negative regulation of small GTPase mediated signal transduction)|go:"GO:0051414"(response to cortisol)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0061364"(apoptotic process involved in luteolysis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070100"(negative regulation of chemokine-mediated signaling pathway)|go:"GO:0071504"(cellular response to heparin)|go:"GO:0071672"(negative regulation of smooth muscle cell chemotaxis)|go:"GO:0071676"(negative regulation of mononuclear cell migration)|go:"GO:0090024"(negative regulation of neutrophil chemotaxis)|go:"GO:0090027"(negative regulation of monocyte chemotaxis)|go:"GO:0090260"(negative regulation of retinal ganglion cell axon guidance)|go:"GO:0090288"(negative regulation of cellular response to growth factor stimulus)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000372(Leucine-rich repeat, cysteine-rich flanking region, N-terminal)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001791(Laminin G)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR003645(Follistatin-like, N-terminal)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR013032(EGF-like region, conserved site)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR018097|interpro:IPR032675|mint:O94813|rcsb pdb:2V70|rcsb pdb:2V9S|rcsb pdb:2V9T|rcsb pdb:2WFH|reactome:R-HSA-373752|reactome:R-HSA-376176|reactome:R-HSA-428540|reactome:R-HSA-428542|reactome:R-HSA-428543|reactome:R-HSA-428890|reactome:R-HSA-8985586|reactome:R-HSA-9010553|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001611(Leucine-rich repeat)|ensembl:ENSG00000145147(gene)|ensembl:ENST00000504154(transcript)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0002689"(negative regulation of leukocyte chemotaxis)|go:"GO:0003180"(aortic valve morphogenesis)|mint:MINT-7218949(identity)	refseq:NP_001276064.1|refseq:NP_001276065.1|refseq:NP_004778.1|dip:DIP-38198N|go:"GO:0003184"(pulmonary valve morphogenesis)|go:"GO:0005095"(GTPase inhibitor activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0035385"(Roundabout signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007411"(axon guidance)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008201"(heparin binding)|go:"GO:0009986"(cell surface)|go:"GO:0010593"(negative regulation of lamellipodium assembly)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0014912"(negative regulation of smooth muscle cell migration)|go:"GO:0016020"(membrane)|go:"GO:0021836"(chemorepulsion involved in postnatal olfactory bulb interneuron migration)|go:"GO:0021972"(corticospinal neuron axon guidance through spinal cord)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030837"(negative regulation of actin filament polymerization)|go:"GO:0031290"(retinal ganglion cell axon guidance)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043116"(negative regulation of vascular permeability)|go:"GO:0043237"(laminin-1 binding)|go:"GO:0043394"(proteoglycan binding)|go:"GO:0048495"(Roundabout binding)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0048846"(axon extension involved in axon guidance)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050919"(negative chemotaxis)|go:"GO:0050929"(induction of negative chemotaxis)|go:"GO:0051058"(negative regulation of small GTPase mediated signal transduction)|go:"GO:0051414"(response to cortisol)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0061364"(apoptotic process involved in luteolysis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070100"(negative regulation of chemokine-mediated signaling pathway)|go:"GO:0071504"(cellular response to heparin)|go:"GO:0071672"(negative regulation of smooth muscle cell chemotaxis)|go:"GO:0071676"(negative regulation of mononuclear cell migration)|go:"GO:0090024"(negative regulation of neutrophil chemotaxis)|go:"GO:0090027"(negative regulation of monocyte chemotaxis)|go:"GO:0090260"(negative regulation of retinal ganglion cell axon guidance)|go:"GO:0090288"(negative regulation of cellular response to growth factor stimulus)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000372(Leucine-rich repeat, cysteine-rich flanking region, N-terminal)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001791(Laminin G)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR003645(Follistatin-like, N-terminal)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR013032(EGF-like region, conserved site)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR018097|interpro:IPR032675|mint:O94813|rcsb pdb:2V70|rcsb pdb:2V9S|rcsb pdb:2V9T|rcsb pdb:2WFH|reactome:R-HSA-373752|reactome:R-HSA-376176|reactome:R-HSA-428540|reactome:R-HSA-428542|reactome:R-HSA-428543|reactome:R-HSA-428890|reactome:R-HSA-8985586|reactome:R-HSA-9010553|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001611(Leucine-rich repeat)|ensembl:ENSG00000145147(gene)|ensembl:ENST00000504154(transcript)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0002689"(negative regulation of leukocyte chemotaxis)|go:"GO:0003180"(aortic valve morphogenesis)|mint:MINT-7218948(identity)	-	-	-	figure legend:f1a|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/07/13	2014/10/16	rogid:25Wc98dEfv1yROTD5pUtyQ+LWN89606	rogid:25Wc98dEfv1yROTD5pUtyQ+LWN89606	intact-crc:50B9E7A48AF5704D|rigid:KJhsguNGvzPH5/thj5LCU1uEzoM	false	binding-associated region:271-907(MINT-7218951)	binding-associated region:271-907(MINT-7218955)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O94813	uniprotkb:O94813	intact:EBI-1236865|uniprotkb:O95710|uniprotkb:Q17RU3|uniprotkb:Q9Y5Q7|uniprotkb:B7ZLR5|uniprotkb:A0A0A6YYB8|ensembl:ENSP00000422591	intact:EBI-1236865|uniprotkb:O95710|uniprotkb:Q17RU3|uniprotkb:Q9Y5Q7|uniprotkb:B7ZLR5|uniprotkb:A0A0A6YYB8|ensembl:ENSP00000422591	psi-mi:slit2_human(display_long)|uniprotkb:SLIT2(gene name)|psi-mi:SLIT2(display_short)|uniprotkb:SLIL3(gene name synonym)	psi-mi:slit2_human(display_long)|uniprotkb:SLIT2(gene name)|psi-mi:SLIT2(display_short)|uniprotkb:SLIL3(gene name synonym)	psi-mi:"MI:0038"(dynamic light scattering)	Seiradake et al. (2009)	pubmed:19498462|imex:IM-14115|mint:MINT-7218932|doi:10.1038/embor.2009.95	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7037949|mint:MINT-7218959|imex:IM-14115-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001276064.1|refseq:NP_001276065.1|refseq:NP_004778.1|dip:DIP-38198N|go:"GO:0003184"(pulmonary valve morphogenesis)|go:"GO:0005095"(GTPase inhibitor activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0035385"(Roundabout signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007411"(axon guidance)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008201"(heparin binding)|go:"GO:0009986"(cell surface)|go:"GO:0010593"(negative regulation of lamellipodium assembly)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0014912"(negative regulation of smooth muscle cell migration)|go:"GO:0016020"(membrane)|go:"GO:0021836"(chemorepulsion involved in postnatal olfactory bulb interneuron migration)|go:"GO:0021972"(corticospinal neuron axon guidance through spinal cord)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030837"(negative regulation of actin filament polymerization)|go:"GO:0031290"(retinal ganglion cell axon guidance)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043116"(negative regulation of vascular permeability)|go:"GO:0043237"(laminin-1 binding)|go:"GO:0043394"(proteoglycan binding)|go:"GO:0048495"(Roundabout binding)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0048846"(axon extension involved in axon guidance)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050919"(negative chemotaxis)|go:"GO:0050929"(induction of negative chemotaxis)|go:"GO:0051058"(negative regulation of small GTPase mediated signal transduction)|go:"GO:0051414"(response to cortisol)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0061364"(apoptotic process involved in luteolysis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070100"(negative regulation of chemokine-mediated signaling pathway)|go:"GO:0071504"(cellular response to heparin)|go:"GO:0071672"(negative regulation of smooth muscle cell chemotaxis)|go:"GO:0071676"(negative regulation of mononuclear cell migration)|go:"GO:0090024"(negative regulation of neutrophil chemotaxis)|go:"GO:0090027"(negative regulation of monocyte chemotaxis)|go:"GO:0090260"(negative regulation of retinal ganglion cell axon guidance)|go:"GO:0090288"(negative regulation of cellular response to growth factor stimulus)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000372(Leucine-rich repeat, cysteine-rich flanking region, N-terminal)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001791(Laminin G)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR003645(Follistatin-like, N-terminal)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR013032(EGF-like region, conserved site)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR018097|interpro:IPR032675|mint:O94813|rcsb pdb:2V70|rcsb pdb:2V9S|rcsb pdb:2V9T|rcsb pdb:2WFH|reactome:R-HSA-373752|reactome:R-HSA-376176|reactome:R-HSA-428540|reactome:R-HSA-428542|reactome:R-HSA-428543|reactome:R-HSA-428890|reactome:R-HSA-8985586|reactome:R-HSA-9010553|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001611(Leucine-rich repeat)|ensembl:ENSG00000145147(gene)|ensembl:ENST00000504154(transcript)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0002689"(negative regulation of leukocyte chemotaxis)|go:"GO:0003180"(aortic valve morphogenesis)|mint:MINT-7218965(identity)	refseq:NP_001276064.1|refseq:NP_001276065.1|refseq:NP_004778.1|dip:DIP-38198N|go:"GO:0003184"(pulmonary valve morphogenesis)|go:"GO:0005095"(GTPase inhibitor activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0035385"(Roundabout signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007411"(axon guidance)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008201"(heparin binding)|go:"GO:0009986"(cell surface)|go:"GO:0010593"(negative regulation of lamellipodium assembly)|go:"GO:0010596"(negative regulation of endothelial cell migration)|go:"GO:0014912"(negative regulation of smooth muscle cell migration)|go:"GO:0016020"(membrane)|go:"GO:0021836"(chemorepulsion involved in postnatal olfactory bulb interneuron migration)|go:"GO:0021972"(corticospinal neuron axon guidance through spinal cord)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030837"(negative regulation of actin filament polymerization)|go:"GO:0031290"(retinal ganglion cell axon guidance)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043116"(negative regulation of vascular permeability)|go:"GO:0043237"(laminin-1 binding)|go:"GO:0043394"(proteoglycan binding)|go:"GO:0048495"(Roundabout binding)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0048846"(axon extension involved in axon guidance)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0050919"(negative chemotaxis)|go:"GO:0050929"(induction of negative chemotaxis)|go:"GO:0051058"(negative regulation of small GTPase mediated signal transduction)|go:"GO:0051414"(response to cortisol)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0061364"(apoptotic process involved in luteolysis)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070100"(negative regulation of chemokine-mediated signaling pathway)|go:"GO:0071504"(cellular response to heparin)|go:"GO:0071672"(negative regulation of smooth muscle cell chemotaxis)|go:"GO:0071676"(negative regulation of mononuclear cell migration)|go:"GO:0090024"(negative regulation of neutrophil chemotaxis)|go:"GO:0090027"(negative regulation of monocyte chemotaxis)|go:"GO:0090260"(negative regulation of retinal ganglion cell axon guidance)|go:"GO:0090288"(negative regulation of cellular response to growth factor stimulus)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000372(Leucine-rich repeat, cysteine-rich flanking region, N-terminal)|interpro:IPR000483(Cysteine-rich flanking region, C-terminal)|interpro:IPR001791(Laminin G)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR003645(Follistatin-like, N-terminal)|interpro:IPR006207(Cystine knot, C-terminal)|interpro:IPR013032(EGF-like region, conserved site)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR018097|interpro:IPR032675|mint:O94813|rcsb pdb:2V70|rcsb pdb:2V9S|rcsb pdb:2V9T|rcsb pdb:2WFH|reactome:R-HSA-373752|reactome:R-HSA-376176|reactome:R-HSA-428540|reactome:R-HSA-428542|reactome:R-HSA-428543|reactome:R-HSA-428890|reactome:R-HSA-8985586|reactome:R-HSA-9010553|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001611(Leucine-rich repeat)|ensembl:ENSG00000145147(gene)|ensembl:ENST00000504154(transcript)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0002689"(negative regulation of leukocyte chemotaxis)|go:"GO:0003180"(aortic valve morphogenesis)|mint:MINT-7218961(identity)	-	-	-	comment:homomint|comment:mint|figure legend:f1B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/07/13	2014/10/16	rogid:25Wc98dEfv1yROTD5pUtyQ+LWN89606	rogid:25Wc98dEfv1yROTD5pUtyQ+LWN89606	intact-crc:347D432075FC6F84|rigid:KJhsguNGvzPH5/thj5LCU1uEzoM	false	binding-associated region:271-907(MINT-7218966)	binding-associated region:271-907(MINT-7218962)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)