#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
chebi:"CHEBI:16761"	intact:EBI-2353423	intact:EBI-1188073	-	psi-mi:adp(display_short)|psi-mi:"CHEBI:16761"(display_long)	psi-mi:ctggcctata(display_short)|psi-mi:EBI-2353423(display_long)	psi-mi:"MI:0114"(x-ray crystallography)	Simonetta et al. (2009)	imex:IM-12185|pubmed:19450514	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2353415|wwpdb:3GLF|imex:IM-12185-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0319"(deoxyribonucleic acid)	-	-	-	-	-	3d-resolution:3.4A|3d-r-factors:"R-factor: 22.34%, Free R-factor: 26.04%"|figure legend:Supp. Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/06/11	2014/10/16	-	crc64:369722C1AEBEB878	intact-crc:CEC51F61A78D06B3	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:16761"	uniprotkb:P06710	intact:EBI-1188073	intact:EBI-549140|uniprotkb:Q2MBV7|uniprotkb:Q47721|uniprotkb:A0A385XJC4|ensemblbacteria:AAC73572|ensemblbacteria:AYC08179|ensemblbacteria:BAE76249	psi-mi:adp(display_short)|psi-mi:"CHEBI:16761"(display_long)	psi-mi:dpo3x_ecoli(display_long)|uniprotkb:dnaX(gene name)|psi-mi:dnaX(display_short)|uniprotkb:dnaZ(gene name synonym)|uniprotkb:dnaZX(gene name synonym)|uniprotkb:b0470(locus name)|uniprotkb:JW0459(locus name)|uniprotkb:DNA polymerase III subunit gamma(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Simonetta et al. (2009)	imex:IM-12185|pubmed:19450514	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2353415|wwpdb:3GLF|imex:IM-12185-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_415003.1|refseq:WP_000122013.1|dip:DIP-9464N|ensemblbacteria:AAC73572(transcript)|ensemblbacteria:AYC08179(transcript)|ensemblbacteria:b0470(gene)|ensemblbacteria:BAE76249(gene)|ensemblbacteria:BAE76249(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006260"(DNA replication)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0009360"(DNA polymerase III complex)|go:"GO:0017111"(nucleoside-triphosphatase activity)|go:"GO:0030337"(DNA polymerase processivity factor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043846"(DNA polymerase III, clamp loader complex)|interpro:IPR001270(Chaperonin clpA/B)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR008921(DNA polymerase III clamp loader subunit, C-terminal)|interpro:IPR012763(DNA polymerase III, subunits gamma and tau)|interpro:IPR021029|interpro:IPR022001|interpro:IPR022754|interpro:IPR027417|interpro:IPR038249|rcsb pdb:1JR3|rcsb pdb:1NJF|rcsb pdb:1NJG|rcsb pdb:1XXH|rcsb pdb:1XXI|rcsb pdb:2AYA|rcsb pdb:3GLF|rcsb pdb:3GLG|rcsb pdb:3GLH|rcsb pdb:3GLI|rcsb pdb:5FKU|rcsb pdb:5FKV	-	-	-	3d-resolution:3.4A|3d-r-factors:"R-factor: 22.34%, Free R-factor: 26.04%"|figure legend:Supp. Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/06/11	2014/10/16	-	rogid:I70gmzAJoBvK53kEZUaKOv/zshg83333	intact-crc:CEC51F61A78D06B3	false	-	his tag:n-n|sufficient binding region:1-395	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:16761"	uniprotkb:P28630	intact:EBI-1188073	intact:EBI-549153|ensemblbacteria:AAC73741|ensemblbacteria:BAA35287	psi-mi:adp(display_short)|psi-mi:"CHEBI:16761"(display_long)	psi-mi:hola_ecoli(display_long)|uniprotkb:b0640(locus name)|uniprotkb:holA(gene name)|psi-mi:holA(display_short)|uniprotkb:JW0635(locus name)	psi-mi:"MI:0114"(x-ray crystallography)	Simonetta et al. (2009)	imex:IM-12185|pubmed:19450514	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2353415|wwpdb:3GLF|imex:IM-12185-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_415173.1|refseq:WP_000620535.1|dip:DIP-9931N|rcsb pdb:3GLG|rcsb pdb:3GLH|rcsb pdb:3GLI|ensemblbacteria:AAC73741(transcript)|ensemblbacteria:b0640(gene)|ensemblbacteria:BAA35287(gene)|ensemblbacteria:BAA35287(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0009360"(DNA polymerase III complex)|interpro:IPR005790(DNA polymerase III, delta subunit)|interpro:IPR008921(DNA polymerase III clamp loader subunit, C-terminal)|interpro:IPR010372(DNA polymerase III, delta)|interpro:IPR027417|interpro:IPR032780|rcsb pdb:1JQJ|rcsb pdb:1JQL|rcsb pdb:1JR3|rcsb pdb:1XXH|rcsb pdb:1XXI|rcsb pdb:3GLF	-	-	crc64:87239A678FE16BE2	3d-resolution:3.4A|3d-r-factors:"R-factor: 22.34%, Free R-factor: 26.04%"|figure legend:Supp. Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/06/11	2014/10/16	-	rogid:xMcC78PZeDNSqwRnRtbA31N1xMg83333	intact-crc:CEC51F61A78D06B3	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:16761"	uniprotkb:P28631	intact:EBI-1188073	intact:EBI-549161|ensemblbacteria:BAA35906|ensemblbacteria:AAC74183	psi-mi:adp(display_short)|psi-mi:"CHEBI:16761"(display_long)	psi-mi:holb_ecoli(display_long)|uniprotkb:holB(gene name)|psi-mi:holB(display_short)|uniprotkb:b1099(locus name)|uniprotkb:JW1085(locus name)	psi-mi:"MI:0114"(x-ray crystallography)	Simonetta et al. (2009)	imex:IM-12185|pubmed:19450514	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2353415|wwpdb:3GLF|imex:IM-12185-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_415617.1|refseq:WP_001267956.1|dip:DIP-9932N|ensemblbacteria:BAA35906(gene)|ensemblbacteria:BAA35906(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0008408"(3'-5' exonuclease activity)|go:"GO:0009360"(DNA polymerase III complex)|interpro:IPR004622(DNA polymerase III, delta prime subunit)|interpro:IPR008921(DNA polymerase III clamp loader subunit, C-terminal)|interpro:IPR015199(DNA polymerase III, delta subunit, C-terminal)|interpro:IPR027417|rcsb pdb:1A5T|rcsb pdb:1JR3|rcsb pdb:1XXH|ensemblbacteria:AAC74183(transcript)|ensemblbacteria:b1099(gene)|rcsb pdb:1XXI|rcsb pdb:3GLF|rcsb pdb:3GLH|rcsb pdb:3GLI|rcsb pdb:3GLG	-	-	-	3d-resolution:3.4A|3d-r-factors:"R-factor: 22.34%, Free R-factor: 26.04%"|figure legend:Supp. Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/06/11	2014/10/16	-	rogid:Wd7zI2kwfKLoHTrbfM9l98atQuw83333	intact-crc:CEC51F61A78D06B3	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:16761"	chebi:"CHEBI:30498"	intact:EBI-1188073	intact:EBI-2120453	psi-mi:adp(display_short)|psi-mi:"CHEBI:16761"(display_long)	psi-mi:"trifluoroberyllate(1-)"(display_short)|psi-mi:"CHEBI:30498"(display_long)	psi-mi:"MI:0114"(x-ray crystallography)	Simonetta et al. (2009)	imex:IM-12185|pubmed:19450514	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2353415|wwpdb:3GLF|imex:IM-12185-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0328"(small molecule)	-	-	-	-	comment:a widely used substitute for the γ-phosphate of ATP	3d-resolution:3.4A|3d-r-factors:"R-factor: 22.34%, Free R-factor: 26.04%"|figure legend:Supp. Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/06/11	2014/10/16	-	-	intact-crc:CEC51F61A78D06B3	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:16761"	intact:EBI-2353421	intact:EBI-1188073	-	psi-mi:adp(display_short)|psi-mi:"CHEBI:16761"(display_long)	psi-mi:ttttttataggccag(display_short)|psi-mi:EBI-2353421(display_long)	psi-mi:"MI:0114"(x-ray crystallography)	Simonetta et al. (2009)	imex:IM-12185|pubmed:19450514	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2353415|wwpdb:3GLF|imex:IM-12185-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0319"(deoxyribonucleic acid)	-	-	-	-	-	3d-resolution:3.4A|3d-r-factors:"R-factor: 22.34%, Free R-factor: 26.04%"|figure legend:Supp. Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/06/11	2014/10/16	-	crc64:8C389AFAFC3C39C5	intact-crc:CEC51F61A78D06B3	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:16761"	intact:EBI-2353423	intact:EBI-1188073	-	psi-mi:adp(display_short)|psi-mi:"CHEBI:16761"(display_long)	psi-mi:ctggcctata(display_short)|psi-mi:EBI-2353423(display_long)	psi-mi:"MI:0114"(x-ray crystallography)	Simonetta et al. (2009)	imex:IM-12185|pubmed:19450514	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2353435|wwpdb:3GLG|imex:IM-12185-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0319"(deoxyribonucleic acid)	-	-	-	-	-	3d-resolution:3.25A|3d-r-factors:"R-factor: 22.6%, Free R-factor: 26.3%"|comment:The Thr157Ala mutation of P06710 prevents ATP hydrolysis.|figure legend:Supp. Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/06/11	2014/10/16	-	crc64:369722C1AEBEB878	intact-crc:DA959723E746952E	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:16761"	uniprotkb:P06710	intact:EBI-1188073	intact:EBI-549140|uniprotkb:Q2MBV7|uniprotkb:Q47721|uniprotkb:A0A385XJC4|ensemblbacteria:AAC73572|ensemblbacteria:AYC08179|ensemblbacteria:BAE76249	psi-mi:adp(display_short)|psi-mi:"CHEBI:16761"(display_long)	psi-mi:dpo3x_ecoli(display_long)|uniprotkb:dnaX(gene name)|psi-mi:dnaX(display_short)|uniprotkb:dnaZ(gene name synonym)|uniprotkb:dnaZX(gene name synonym)|uniprotkb:b0470(locus name)|uniprotkb:JW0459(locus name)|uniprotkb:DNA polymerase III subunit gamma(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Simonetta et al. (2009)	imex:IM-12185|pubmed:19450514	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2353435|wwpdb:3GLG|imex:IM-12185-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_415003.1|refseq:WP_000122013.1|dip:DIP-9464N|ensemblbacteria:AAC73572(transcript)|ensemblbacteria:AYC08179(transcript)|ensemblbacteria:b0470(gene)|ensemblbacteria:BAE76249(gene)|ensemblbacteria:BAE76249(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006260"(DNA replication)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0009360"(DNA polymerase III complex)|go:"GO:0017111"(nucleoside-triphosphatase activity)|go:"GO:0030337"(DNA polymerase processivity factor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043846"(DNA polymerase III, clamp loader complex)|interpro:IPR001270(Chaperonin clpA/B)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR008921(DNA polymerase III clamp loader subunit, C-terminal)|interpro:IPR012763(DNA polymerase III, subunits gamma and tau)|interpro:IPR021029|interpro:IPR022001|interpro:IPR022754|interpro:IPR027417|interpro:IPR038249|rcsb pdb:1JR3|rcsb pdb:1NJF|rcsb pdb:1NJG|rcsb pdb:1XXH|rcsb pdb:1XXI|rcsb pdb:2AYA|rcsb pdb:3GLF|rcsb pdb:3GLG|rcsb pdb:3GLH|rcsb pdb:3GLI|rcsb pdb:5FKU|rcsb pdb:5FKV	-	-	-	3d-resolution:3.25A|3d-r-factors:"R-factor: 22.6%, Free R-factor: 26.3%"|comment:The Thr157Ala mutation of P06710 prevents ATP hydrolysis.|figure legend:Supp. Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/06/11	2014/10/16	-	rogid:I70gmzAJoBvK53kEZUaKOv/zshg83333	intact-crc:DA959723E746952E	false	-	his tag:n-n|sufficient binding region:1-395|mutation:157-157	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:16761"	uniprotkb:P28630	intact:EBI-1188073	intact:EBI-549153|ensemblbacteria:AAC73741|ensemblbacteria:BAA35287	psi-mi:adp(display_short)|psi-mi:"CHEBI:16761"(display_long)	psi-mi:hola_ecoli(display_long)|uniprotkb:b0640(locus name)|uniprotkb:holA(gene name)|psi-mi:holA(display_short)|uniprotkb:JW0635(locus name)	psi-mi:"MI:0114"(x-ray crystallography)	Simonetta et al. (2009)	imex:IM-12185|pubmed:19450514	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2353435|wwpdb:3GLG|imex:IM-12185-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_415173.1|refseq:WP_000620535.1|dip:DIP-9931N|rcsb pdb:3GLG|rcsb pdb:3GLH|rcsb pdb:3GLI|ensemblbacteria:AAC73741(transcript)|ensemblbacteria:b0640(gene)|ensemblbacteria:BAA35287(gene)|ensemblbacteria:BAA35287(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0009360"(DNA polymerase III complex)|interpro:IPR005790(DNA polymerase III, delta subunit)|interpro:IPR008921(DNA polymerase III clamp loader subunit, C-terminal)|interpro:IPR010372(DNA polymerase III, delta)|interpro:IPR027417|interpro:IPR032780|rcsb pdb:1JQJ|rcsb pdb:1JQL|rcsb pdb:1JR3|rcsb pdb:1XXH|rcsb pdb:1XXI|rcsb pdb:3GLF	-	-	crc64:87239A678FE16BE2	3d-resolution:3.25A|3d-r-factors:"R-factor: 22.6%, Free R-factor: 26.3%"|comment:The Thr157Ala mutation of P06710 prevents ATP hydrolysis.|figure legend:Supp. Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/06/11	2014/10/16	-	rogid:xMcC78PZeDNSqwRnRtbA31N1xMg83333	intact-crc:DA959723E746952E	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:16761"	uniprotkb:P28631	intact:EBI-1188073	intact:EBI-549161|ensemblbacteria:BAA35906|ensemblbacteria:AAC74183	psi-mi:adp(display_short)|psi-mi:"CHEBI:16761"(display_long)	psi-mi:holb_ecoli(display_long)|uniprotkb:holB(gene name)|psi-mi:holB(display_short)|uniprotkb:b1099(locus name)|uniprotkb:JW1085(locus name)	psi-mi:"MI:0114"(x-ray crystallography)	Simonetta et al. (2009)	imex:IM-12185|pubmed:19450514	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2353435|wwpdb:3GLG|imex:IM-12185-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_415617.1|refseq:WP_001267956.1|dip:DIP-9932N|ensemblbacteria:BAA35906(gene)|ensemblbacteria:BAA35906(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0008408"(3'-5' exonuclease activity)|go:"GO:0009360"(DNA polymerase III complex)|interpro:IPR004622(DNA polymerase III, delta prime subunit)|interpro:IPR008921(DNA polymerase III clamp loader subunit, C-terminal)|interpro:IPR015199(DNA polymerase III, delta subunit, C-terminal)|interpro:IPR027417|rcsb pdb:1A5T|rcsb pdb:1JR3|rcsb pdb:1XXH|ensemblbacteria:AAC74183(transcript)|ensemblbacteria:b1099(gene)|rcsb pdb:1XXI|rcsb pdb:3GLF|rcsb pdb:3GLH|rcsb pdb:3GLI|rcsb pdb:3GLG	-	-	-	3d-resolution:3.25A|3d-r-factors:"R-factor: 22.6%, Free R-factor: 26.3%"|comment:The Thr157Ala mutation of P06710 prevents ATP hydrolysis.|figure legend:Supp. Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/06/11	2014/10/16	-	rogid:Wd7zI2kwfKLoHTrbfM9l98atQuw83333	intact-crc:DA959723E746952E	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:16761"	chebi:"CHEBI:30498"	intact:EBI-1188073	intact:EBI-2120453	psi-mi:adp(display_short)|psi-mi:"CHEBI:16761"(display_long)	psi-mi:"trifluoroberyllate(1-)"(display_short)|psi-mi:"CHEBI:30498"(display_long)	psi-mi:"MI:0114"(x-ray crystallography)	Simonetta et al. (2009)	imex:IM-12185|pubmed:19450514	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2353435|wwpdb:3GLG|imex:IM-12185-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0328"(small molecule)	-	-	-	-	comment:a widely used substitute for the γ-phosphate of ATP	3d-resolution:3.25A|3d-r-factors:"R-factor: 22.6%, Free R-factor: 26.3%"|comment:The Thr157Ala mutation of P06710 prevents ATP hydrolysis.|figure legend:Supp. Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/06/11	2014/10/16	-	-	intact-crc:DA959723E746952E	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:16761"	intact:EBI-2353421	intact:EBI-1188073	-	psi-mi:adp(display_short)|psi-mi:"CHEBI:16761"(display_long)	psi-mi:ttttttataggccag(display_short)|psi-mi:EBI-2353421(display_long)	psi-mi:"MI:0114"(x-ray crystallography)	Simonetta et al. (2009)	imex:IM-12185|pubmed:19450514	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2353435|wwpdb:3GLG|imex:IM-12185-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0319"(deoxyribonucleic acid)	-	-	-	-	-	3d-resolution:3.25A|3d-r-factors:"R-factor: 22.6%, Free R-factor: 26.3%"|comment:The Thr157Ala mutation of P06710 prevents ATP hydrolysis.|figure legend:Supp. Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/06/11	2014/10/16	-	crc64:8C389AFAFC3C39C5	intact-crc:DA959723E746952E	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06710	uniprotkb:P28630	intact:EBI-549140|uniprotkb:Q2MBV7|uniprotkb:Q47721|uniprotkb:A0A385XJC4|ensemblbacteria:AAC73572|ensemblbacteria:AYC08179|ensemblbacteria:BAE76249	intact:EBI-549153|ensemblbacteria:AAC73741|ensemblbacteria:BAA35287	psi-mi:dpo3x_ecoli(display_long)|uniprotkb:dnaX(gene name)|psi-mi:dnaX(display_short)|uniprotkb:dnaZ(gene name synonym)|uniprotkb:dnaZX(gene name synonym)|uniprotkb:b0470(locus name)|uniprotkb:JW0459(locus name)|uniprotkb:DNA polymerase III subunit gamma(gene name synonym)	psi-mi:hola_ecoli(display_long)|uniprotkb:b0640(locus name)|uniprotkb:holA(gene name)|psi-mi:holA(display_short)|uniprotkb:JW0635(locus name)	psi-mi:"MI:0114"(x-ray crystallography)	Simonetta et al. (2009)	imex:IM-12185|pubmed:19450514	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2353545|wwpdb:3GLH|imex:IM-12185-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_415003.1|refseq:WP_000122013.1|dip:DIP-9464N|ensemblbacteria:AAC73572(transcript)|ensemblbacteria:AYC08179(transcript)|ensemblbacteria:b0470(gene)|ensemblbacteria:BAE76249(gene)|ensemblbacteria:BAE76249(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006260"(DNA replication)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0009360"(DNA polymerase III complex)|go:"GO:0017111"(nucleoside-triphosphatase activity)|go:"GO:0030337"(DNA polymerase processivity factor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043846"(DNA polymerase III, clamp loader complex)|interpro:IPR001270(Chaperonin clpA/B)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR008921(DNA polymerase III clamp loader subunit, C-terminal)|interpro:IPR012763(DNA polymerase III, subunits gamma and tau)|interpro:IPR021029|interpro:IPR022001|interpro:IPR022754|interpro:IPR027417|interpro:IPR038249|rcsb pdb:1JR3|rcsb pdb:1NJF|rcsb pdb:1NJG|rcsb pdb:1XXH|rcsb pdb:1XXI|rcsb pdb:2AYA|rcsb pdb:3GLF|rcsb pdb:3GLG|rcsb pdb:3GLH|rcsb pdb:3GLI|rcsb pdb:5FKU|rcsb pdb:5FKV	refseq:NP_415173.1|refseq:WP_000620535.1|dip:DIP-9931N|rcsb pdb:3GLG|rcsb pdb:3GLH|rcsb pdb:3GLI|ensemblbacteria:AAC73741(transcript)|ensemblbacteria:b0640(gene)|ensemblbacteria:BAA35287(gene)|ensemblbacteria:BAA35287(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0009360"(DNA polymerase III complex)|interpro:IPR005790(DNA polymerase III, delta subunit)|interpro:IPR008921(DNA polymerase III clamp loader subunit, C-terminal)|interpro:IPR010372(DNA polymerase III, delta)|interpro:IPR027417|interpro:IPR032780|rcsb pdb:1JQJ|rcsb pdb:1JQL|rcsb pdb:1JR3|rcsb pdb:1XXH|rcsb pdb:1XXI|rcsb pdb:3GLF	-	-	crc64:87239A678FE16BE2	3d-resolution:3.9A|3d-r-factors:"R-factor: 35.93%, Free R-factor: 36.14%"|figure legend:Supp. Table 6|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/06/11	2014/10/16	rogid:I70gmzAJoBvK53kEZUaKOv/zshg83333	rogid:xMcC78PZeDNSqwRnRtbA31N1xMg83333	intact-crc:5C9966A38496DB4A|rigid:BKqB83gB/pa0PCKfIZ5XWvKGr84	false	his tag:n-n|sufficient binding region:1-376	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06710	uniprotkb:P28631	intact:EBI-549140|uniprotkb:Q2MBV7|uniprotkb:Q47721|uniprotkb:A0A385XJC4|ensemblbacteria:AAC73572|ensemblbacteria:AYC08179|ensemblbacteria:BAE76249	intact:EBI-549161|ensemblbacteria:BAA35906|ensemblbacteria:AAC74183	psi-mi:dpo3x_ecoli(display_long)|uniprotkb:dnaX(gene name)|psi-mi:dnaX(display_short)|uniprotkb:dnaZ(gene name synonym)|uniprotkb:dnaZX(gene name synonym)|uniprotkb:b0470(locus name)|uniprotkb:JW0459(locus name)|uniprotkb:DNA polymerase III subunit gamma(gene name synonym)	psi-mi:holb_ecoli(display_long)|uniprotkb:holB(gene name)|psi-mi:holB(display_short)|uniprotkb:b1099(locus name)|uniprotkb:JW1085(locus name)	psi-mi:"MI:0114"(x-ray crystallography)	Simonetta et al. (2009)	imex:IM-12185|pubmed:19450514	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2353545|wwpdb:3GLH|imex:IM-12185-1	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_415003.1|refseq:WP_000122013.1|dip:DIP-9464N|ensemblbacteria:AAC73572(transcript)|ensemblbacteria:AYC08179(transcript)|ensemblbacteria:b0470(gene)|ensemblbacteria:BAE76249(gene)|ensemblbacteria:BAE76249(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006260"(DNA replication)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0009360"(DNA polymerase III complex)|go:"GO:0017111"(nucleoside-triphosphatase activity)|go:"GO:0030337"(DNA polymerase processivity factor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043846"(DNA polymerase III, clamp loader complex)|interpro:IPR001270(Chaperonin clpA/B)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR008921(DNA polymerase III clamp loader subunit, C-terminal)|interpro:IPR012763(DNA polymerase III, subunits gamma and tau)|interpro:IPR021029|interpro:IPR022001|interpro:IPR022754|interpro:IPR027417|interpro:IPR038249|rcsb pdb:1JR3|rcsb pdb:1NJF|rcsb pdb:1NJG|rcsb pdb:1XXH|rcsb pdb:1XXI|rcsb pdb:2AYA|rcsb pdb:3GLF|rcsb pdb:3GLG|rcsb pdb:3GLH|rcsb pdb:3GLI|rcsb pdb:5FKU|rcsb pdb:5FKV	refseq:NP_415617.1|refseq:WP_001267956.1|dip:DIP-9932N|ensemblbacteria:BAA35906(gene)|ensemblbacteria:BAA35906(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0008408"(3'-5' exonuclease activity)|go:"GO:0009360"(DNA polymerase III complex)|interpro:IPR004622(DNA polymerase III, delta prime subunit)|interpro:IPR008921(DNA polymerase III clamp loader subunit, C-terminal)|interpro:IPR015199(DNA polymerase III, delta subunit, C-terminal)|interpro:IPR027417|rcsb pdb:1A5T|rcsb pdb:1JR3|rcsb pdb:1XXH|ensemblbacteria:AAC74183(transcript)|ensemblbacteria:b1099(gene)|rcsb pdb:1XXI|rcsb pdb:3GLF|rcsb pdb:3GLH|rcsb pdb:3GLI|rcsb pdb:3GLG	-	-	-	3d-resolution:3.9A|3d-r-factors:"R-factor: 35.93%, Free R-factor: 36.14%"|figure legend:Supp. Table 6|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/06/11	2014/10/16	rogid:I70gmzAJoBvK53kEZUaKOv/zshg83333	rogid:Wd7zI2kwfKLoHTrbfM9l98atQuw83333	intact-crc:5C9966A38496DB4A|rigid:BKqB83gB/pa0PCKfIZ5XWvKGr84	false	his tag:n-n|sufficient binding region:1-376	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:16761"	intact:EBI-2353423	intact:EBI-1188073	-	psi-mi:adp(display_short)|psi-mi:"CHEBI:16761"(display_long)	psi-mi:ctggcctata(display_short)|psi-mi:EBI-2353423(display_long)	psi-mi:"MI:0114"(x-ray crystallography)	Simonetta et al. (2009)	imex:IM-12185|pubmed:19450514	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2353566|wwpdb:3GLI|imex:IM-12185-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0319"(deoxyribonucleic acid)	-	-	-	-	-	3d-resolution:3.5A|3d-r-factors:"R-factor: 22.34%, Free R-factor: 25.73%"|figure legend:Supp. Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/06/11	2014/10/16	-	crc64:369722C1AEBEB878	intact-crc:7672DA0EDBE8EBB1	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:16761"	uniprotkb:P06710	intact:EBI-1188073	intact:EBI-549140|uniprotkb:Q2MBV7|uniprotkb:Q47721|uniprotkb:A0A385XJC4|ensemblbacteria:AAC73572|ensemblbacteria:AYC08179|ensemblbacteria:BAE76249	psi-mi:adp(display_short)|psi-mi:"CHEBI:16761"(display_long)	psi-mi:dpo3x_ecoli(display_long)|uniprotkb:dnaX(gene name)|psi-mi:dnaX(display_short)|uniprotkb:dnaZ(gene name synonym)|uniprotkb:dnaZX(gene name synonym)|uniprotkb:b0470(locus name)|uniprotkb:JW0459(locus name)|uniprotkb:DNA polymerase III subunit gamma(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Simonetta et al. (2009)	imex:IM-12185|pubmed:19450514	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2353566|wwpdb:3GLI|imex:IM-12185-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_415003.1|refseq:WP_000122013.1|dip:DIP-9464N|ensemblbacteria:AAC73572(transcript)|ensemblbacteria:AYC08179(transcript)|ensemblbacteria:b0470(gene)|ensemblbacteria:BAE76249(gene)|ensemblbacteria:BAE76249(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006260"(DNA replication)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0009360"(DNA polymerase III complex)|go:"GO:0017111"(nucleoside-triphosphatase activity)|go:"GO:0030337"(DNA polymerase processivity factor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043846"(DNA polymerase III, clamp loader complex)|interpro:IPR001270(Chaperonin clpA/B)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR008921(DNA polymerase III clamp loader subunit, C-terminal)|interpro:IPR012763(DNA polymerase III, subunits gamma and tau)|interpro:IPR021029|interpro:IPR022001|interpro:IPR022754|interpro:IPR027417|interpro:IPR038249|rcsb pdb:1JR3|rcsb pdb:1NJF|rcsb pdb:1NJG|rcsb pdb:1XXH|rcsb pdb:1XXI|rcsb pdb:2AYA|rcsb pdb:3GLF|rcsb pdb:3GLG|rcsb pdb:3GLH|rcsb pdb:3GLI|rcsb pdb:5FKU|rcsb pdb:5FKV	-	-	-	3d-resolution:3.5A|3d-r-factors:"R-factor: 22.34%, Free R-factor: 25.73%"|figure legend:Supp. Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/06/11	2014/10/16	-	rogid:I70gmzAJoBvK53kEZUaKOv/zshg83333	intact-crc:7672DA0EDBE8EBB1	false	-	his tag:n-n|sufficient binding region:1-395	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:16761"	uniprotkb:P28630	intact:EBI-1188073	intact:EBI-549153|ensemblbacteria:AAC73741|ensemblbacteria:BAA35287	psi-mi:adp(display_short)|psi-mi:"CHEBI:16761"(display_long)	psi-mi:hola_ecoli(display_long)|uniprotkb:b0640(locus name)|uniprotkb:holA(gene name)|psi-mi:holA(display_short)|uniprotkb:JW0635(locus name)	psi-mi:"MI:0114"(x-ray crystallography)	Simonetta et al. (2009)	imex:IM-12185|pubmed:19450514	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2353566|wwpdb:3GLI|imex:IM-12185-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_415173.1|refseq:WP_000620535.1|dip:DIP-9931N|rcsb pdb:3GLG|rcsb pdb:3GLH|rcsb pdb:3GLI|ensemblbacteria:AAC73741(transcript)|ensemblbacteria:b0640(gene)|ensemblbacteria:BAA35287(gene)|ensemblbacteria:BAA35287(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0009360"(DNA polymerase III complex)|interpro:IPR005790(DNA polymerase III, delta subunit)|interpro:IPR008921(DNA polymerase III clamp loader subunit, C-terminal)|interpro:IPR010372(DNA polymerase III, delta)|interpro:IPR027417|interpro:IPR032780|rcsb pdb:1JQJ|rcsb pdb:1JQL|rcsb pdb:1JR3|rcsb pdb:1XXH|rcsb pdb:1XXI|rcsb pdb:3GLF	-	-	crc64:87239A678FE16BE2	3d-resolution:3.5A|3d-r-factors:"R-factor: 22.34%, Free R-factor: 25.73%"|figure legend:Supp. Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/06/11	2014/10/16	-	rogid:xMcC78PZeDNSqwRnRtbA31N1xMg83333	intact-crc:7672DA0EDBE8EBB1	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:16761"	uniprotkb:P28631	intact:EBI-1188073	intact:EBI-549161|ensemblbacteria:BAA35906|ensemblbacteria:AAC74183	psi-mi:adp(display_short)|psi-mi:"CHEBI:16761"(display_long)	psi-mi:holb_ecoli(display_long)|uniprotkb:holB(gene name)|psi-mi:holB(display_short)|uniprotkb:b1099(locus name)|uniprotkb:JW1085(locus name)	psi-mi:"MI:0114"(x-ray crystallography)	Simonetta et al. (2009)	imex:IM-12185|pubmed:19450514	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2353566|wwpdb:3GLI|imex:IM-12185-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_415617.1|refseq:WP_001267956.1|dip:DIP-9932N|ensemblbacteria:BAA35906(gene)|ensemblbacteria:BAA35906(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0008408"(3'-5' exonuclease activity)|go:"GO:0009360"(DNA polymerase III complex)|interpro:IPR004622(DNA polymerase III, delta prime subunit)|interpro:IPR008921(DNA polymerase III clamp loader subunit, C-terminal)|interpro:IPR015199(DNA polymerase III, delta subunit, C-terminal)|interpro:IPR027417|rcsb pdb:1A5T|rcsb pdb:1JR3|rcsb pdb:1XXH|ensemblbacteria:AAC74183(transcript)|ensemblbacteria:b1099(gene)|rcsb pdb:1XXI|rcsb pdb:3GLF|rcsb pdb:3GLH|rcsb pdb:3GLI|rcsb pdb:3GLG	-	-	-	3d-resolution:3.5A|3d-r-factors:"R-factor: 22.34%, Free R-factor: 25.73%"|figure legend:Supp. Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/06/11	2014/10/16	-	rogid:Wd7zI2kwfKLoHTrbfM9l98atQuw83333	intact-crc:7672DA0EDBE8EBB1	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:16761"	uniprotkb:P28632	intact:EBI-1188073	intact:EBI-549176|uniprotkb:Q2M5U6|ensemblbacteria:AAC77325|ensemblbacteria:BAE78360	psi-mi:adp(display_short)|psi-mi:"CHEBI:16761"(display_long)	psi-mi:hold_ecoli(display_long)|uniprotkb:holD(gene name)|psi-mi:holD(display_short)|uniprotkb:b4372(locus name)|uniprotkb:JW4334(locus name)	psi-mi:"MI:0114"(x-ray crystallography)	Simonetta et al. (2009)	imex:IM-12185|pubmed:19450514	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2353566|wwpdb:3GLI|imex:IM-12185-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	-	refseq:NP_418789.1|refseq:WP_000204012.1|dip:DIP-9934N|ensemblbacteria:AAC77325(transcript)|ensemblbacteria:b4372(gene)|ensemblbacteria:BAE78360(gene)|ensemblbacteria:BAE78360(transcript)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0006260"(DNA replication)|go:"GO:0008408"(3'-5' exonuclease activity)|go:"GO:0009314"(response to radiation)|interpro:IPR004615(DNA polymerase III, psi subunit)|interpro:IPR018382|interpro:IPR036654|rcsb pdb:1EM8|rcsb pdb:3GLI|rcsb pdb:3SXU	-	-	-	3d-resolution:3.5A|3d-r-factors:"R-factor: 22.34%, Free R-factor: 25.73%"|figure legend:Supp. Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/06/11	2014/10/16	-	rogid:w1FQAOKGyqkQNCRGnGeAoy5Odbk83333	intact-crc:7672DA0EDBE8EBB1	false	-	sufficient binding region:2-28	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:16761"	chebi:"CHEBI:30498"	intact:EBI-1188073	intact:EBI-2120453	psi-mi:adp(display_short)|psi-mi:"CHEBI:16761"(display_long)	psi-mi:"trifluoroberyllate(1-)"(display_short)|psi-mi:"CHEBI:30498"(display_long)	psi-mi:"MI:0114"(x-ray crystallography)	Simonetta et al. (2009)	imex:IM-12185|pubmed:19450514	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2353566|wwpdb:3GLI|imex:IM-12185-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0328"(small molecule)	-	-	-	-	comment:a widely used substitute for the γ-phosphate of ATP	3d-resolution:3.5A|3d-r-factors:"R-factor: 22.34%, Free R-factor: 25.73%"|figure legend:Supp. Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/06/11	2014/10/16	-	-	intact-crc:7672DA0EDBE8EBB1	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
chebi:"CHEBI:16761"	intact:EBI-2353421	intact:EBI-1188073	-	psi-mi:adp(display_short)|psi-mi:"CHEBI:16761"(display_long)	psi-mi:ttttttataggccag(display_short)|psi-mi:EBI-2353421(display_long)	psi-mi:"MI:0114"(x-ray crystallography)	Simonetta et al. (2009)	imex:IM-12185|pubmed:19450514	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2353566|wwpdb:3GLI|imex:IM-12185-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0319"(deoxyribonucleic acid)	-	-	-	-	-	3d-resolution:3.5A|3d-r-factors:"R-factor: 22.34%, Free R-factor: 25.73%"|figure legend:Supp. Table 4|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/06/11	2014/10/16	-	crc64:8C389AFAFC3C39C5	intact-crc:7672DA0EDBE8EBB1	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06710	intact:EBI-2353791	intact:EBI-549140|uniprotkb:Q2MBV7|uniprotkb:Q47721|uniprotkb:A0A385XJC4|ensemblbacteria:AAC73572|ensemblbacteria:AYC08179|ensemblbacteria:BAE76249	-	psi-mi:dpo3x_ecoli(display_long)|uniprotkb:dnaX(gene name)|psi-mi:dnaX(display_short)|uniprotkb:dnaZ(gene name synonym)|uniprotkb:dnaZX(gene name synonym)|uniprotkb:b0470(locus name)|uniprotkb:JW0459(locus name)|uniprotkb:DNA polymerase III subunit gamma(gene name synonym)	psi-mi:gggacgcacgcggcattcaa(display_short)|psi-mi:EBI-2353791(display_long)	psi-mi:"MI:0053"(fluorescence polarization spectroscopy)	Simonetta et al. (2009)	imex:IM-12185|pubmed:19450514	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2353743|imex:IM-12185-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0319"(deoxyribonucleic acid)	refseq:NP_415003.1|refseq:WP_000122013.1|dip:DIP-9464N|ensemblbacteria:AAC73572(transcript)|ensemblbacteria:AYC08179(transcript)|ensemblbacteria:b0470(gene)|ensemblbacteria:BAE76249(gene)|ensemblbacteria:BAE76249(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006260"(DNA replication)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0009360"(DNA polymerase III complex)|go:"GO:0017111"(nucleoside-triphosphatase activity)|go:"GO:0030337"(DNA polymerase processivity factor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043846"(DNA polymerase III, clamp loader complex)|interpro:IPR001270(Chaperonin clpA/B)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR008921(DNA polymerase III clamp loader subunit, C-terminal)|interpro:IPR012763(DNA polymerase III, subunits gamma and tau)|interpro:IPR021029|interpro:IPR022001|interpro:IPR022754|interpro:IPR027417|interpro:IPR038249|rcsb pdb:1JR3|rcsb pdb:1NJF|rcsb pdb:1NJG|rcsb pdb:1XXH|rcsb pdb:1XXI|rcsb pdb:2AYA|rcsb pdb:3GLF|rcsb pdb:3GLG|rcsb pdb:3GLH|rcsb pdb:3GLI|rcsb pdb:5FKU|rcsb pdb:5FKV	-	-	-	-	figure legend:Figs. 4B, 6B|kinetics:"KD for DNA binding = 1.8E-7M. Mutation of Lys 313 and Arg 248, which interact with the phosphate group of the nucleotide at the -1 position, increases the value of KD to 6.1 E-6M and 1.3 E-6M for the mutants, respectively. Mutation of Arg 252, which interacts with the phosphate group of the nucleotide at the -2 position in the overhang, had a smaller effect (KD = 7.6E-7M)."|kinetic_conditions:pH=7.5, Temp=25C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/06/11	2014/10/16	rogid:I70gmzAJoBvK53kEZUaKOv/zshg83333	crc64:B7ABD258A1E51976	intact-crc:3D8929A4DB4D013A	false	sufficient binding region:1-373	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06710	uniprotkb:P28630	intact:EBI-549140|uniprotkb:Q2MBV7|uniprotkb:Q47721|uniprotkb:A0A385XJC4|ensemblbacteria:AAC73572|ensemblbacteria:AYC08179|ensemblbacteria:BAE76249	intact:EBI-549153|ensemblbacteria:AAC73741|ensemblbacteria:BAA35287	psi-mi:dpo3x_ecoli(display_long)|uniprotkb:dnaX(gene name)|psi-mi:dnaX(display_short)|uniprotkb:dnaZ(gene name synonym)|uniprotkb:dnaZX(gene name synonym)|uniprotkb:b0470(locus name)|uniprotkb:JW0459(locus name)|uniprotkb:DNA polymerase III subunit gamma(gene name synonym)	psi-mi:hola_ecoli(display_long)|uniprotkb:b0640(locus name)|uniprotkb:holA(gene name)|psi-mi:holA(display_short)|uniprotkb:JW0635(locus name)	psi-mi:"MI:0053"(fluorescence polarization spectroscopy)	Simonetta et al. (2009)	imex:IM-12185|pubmed:19450514	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2353743|imex:IM-12185-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_415003.1|refseq:WP_000122013.1|dip:DIP-9464N|ensemblbacteria:AAC73572(transcript)|ensemblbacteria:AYC08179(transcript)|ensemblbacteria:b0470(gene)|ensemblbacteria:BAE76249(gene)|ensemblbacteria:BAE76249(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006260"(DNA replication)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0009360"(DNA polymerase III complex)|go:"GO:0017111"(nucleoside-triphosphatase activity)|go:"GO:0030337"(DNA polymerase processivity factor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043846"(DNA polymerase III, clamp loader complex)|interpro:IPR001270(Chaperonin clpA/B)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR008921(DNA polymerase III clamp loader subunit, C-terminal)|interpro:IPR012763(DNA polymerase III, subunits gamma and tau)|interpro:IPR021029|interpro:IPR022001|interpro:IPR022754|interpro:IPR027417|interpro:IPR038249|rcsb pdb:1JR3|rcsb pdb:1NJF|rcsb pdb:1NJG|rcsb pdb:1XXH|rcsb pdb:1XXI|rcsb pdb:2AYA|rcsb pdb:3GLF|rcsb pdb:3GLG|rcsb pdb:3GLH|rcsb pdb:3GLI|rcsb pdb:5FKU|rcsb pdb:5FKV	refseq:NP_415173.1|refseq:WP_000620535.1|dip:DIP-9931N|rcsb pdb:3GLG|rcsb pdb:3GLH|rcsb pdb:3GLI|ensemblbacteria:AAC73741(transcript)|ensemblbacteria:b0640(gene)|ensemblbacteria:BAA35287(gene)|ensemblbacteria:BAA35287(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0009360"(DNA polymerase III complex)|interpro:IPR005790(DNA polymerase III, delta subunit)|interpro:IPR008921(DNA polymerase III clamp loader subunit, C-terminal)|interpro:IPR010372(DNA polymerase III, delta)|interpro:IPR027417|interpro:IPR032780|rcsb pdb:1JQJ|rcsb pdb:1JQL|rcsb pdb:1JR3|rcsb pdb:1XXH|rcsb pdb:1XXI|rcsb pdb:3GLF	-	-	crc64:87239A678FE16BE2	figure legend:Figs. 4B, 6B|kinetics:"KD for DNA binding = 1.8E-7M. Mutation of Lys 313 and Arg 248, which interact with the phosphate group of the nucleotide at the -1 position, increases the value of KD to 6.1 E-6M and 1.3 E-6M for the mutants, respectively. Mutation of Arg 252, which interacts with the phosphate group of the nucleotide at the -2 position in the overhang, had a smaller effect (KD = 7.6E-7M)."|kinetic_conditions:pH=7.5, Temp=25C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/06/11	2014/10/16	rogid:I70gmzAJoBvK53kEZUaKOv/zshg83333	rogid:xMcC78PZeDNSqwRnRtbA31N1xMg83333	intact-crc:3D8929A4DB4D013A	false	sufficient binding region:1-373	mutation decreasing interaction strength:252-252|mutation decreasing interaction strength:248-248|mutation decreasing interaction strength:313-313	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06710	uniprotkb:P28631	intact:EBI-549140|uniprotkb:Q2MBV7|uniprotkb:Q47721|uniprotkb:A0A385XJC4|ensemblbacteria:AAC73572|ensemblbacteria:AYC08179|ensemblbacteria:BAE76249	intact:EBI-549161|ensemblbacteria:BAA35906|ensemblbacteria:AAC74183	psi-mi:dpo3x_ecoli(display_long)|uniprotkb:dnaX(gene name)|psi-mi:dnaX(display_short)|uniprotkb:dnaZ(gene name synonym)|uniprotkb:dnaZX(gene name synonym)|uniprotkb:b0470(locus name)|uniprotkb:JW0459(locus name)|uniprotkb:DNA polymerase III subunit gamma(gene name synonym)	psi-mi:holb_ecoli(display_long)|uniprotkb:holB(gene name)|psi-mi:holB(display_short)|uniprotkb:b1099(locus name)|uniprotkb:JW1085(locus name)	psi-mi:"MI:0053"(fluorescence polarization spectroscopy)	Simonetta et al. (2009)	imex:IM-12185|pubmed:19450514	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2353743|imex:IM-12185-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_415003.1|refseq:WP_000122013.1|dip:DIP-9464N|ensemblbacteria:AAC73572(transcript)|ensemblbacteria:AYC08179(transcript)|ensemblbacteria:b0470(gene)|ensemblbacteria:BAE76249(gene)|ensemblbacteria:BAE76249(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006260"(DNA replication)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0009360"(DNA polymerase III complex)|go:"GO:0017111"(nucleoside-triphosphatase activity)|go:"GO:0030337"(DNA polymerase processivity factor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043846"(DNA polymerase III, clamp loader complex)|interpro:IPR001270(Chaperonin clpA/B)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR008921(DNA polymerase III clamp loader subunit, C-terminal)|interpro:IPR012763(DNA polymerase III, subunits gamma and tau)|interpro:IPR021029|interpro:IPR022001|interpro:IPR022754|interpro:IPR027417|interpro:IPR038249|rcsb pdb:1JR3|rcsb pdb:1NJF|rcsb pdb:1NJG|rcsb pdb:1XXH|rcsb pdb:1XXI|rcsb pdb:2AYA|rcsb pdb:3GLF|rcsb pdb:3GLG|rcsb pdb:3GLH|rcsb pdb:3GLI|rcsb pdb:5FKU|rcsb pdb:5FKV	refseq:NP_415617.1|refseq:WP_001267956.1|dip:DIP-9932N|ensemblbacteria:BAA35906(gene)|ensemblbacteria:BAA35906(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0008408"(3'-5' exonuclease activity)|go:"GO:0009360"(DNA polymerase III complex)|interpro:IPR004622(DNA polymerase III, delta prime subunit)|interpro:IPR008921(DNA polymerase III clamp loader subunit, C-terminal)|interpro:IPR015199(DNA polymerase III, delta subunit, C-terminal)|interpro:IPR027417|rcsb pdb:1A5T|rcsb pdb:1JR3|rcsb pdb:1XXH|ensemblbacteria:AAC74183(transcript)|ensemblbacteria:b1099(gene)|rcsb pdb:1XXI|rcsb pdb:3GLF|rcsb pdb:3GLH|rcsb pdb:3GLI|rcsb pdb:3GLG	-	-	-	figure legend:Figs. 4B, 6B|kinetics:"KD for DNA binding = 1.8E-7M. Mutation of Lys 313 and Arg 248, which interact with the phosphate group of the nucleotide at the -1 position, increases the value of KD to 6.1 E-6M and 1.3 E-6M for the mutants, respectively. Mutation of Arg 252, which interacts with the phosphate group of the nucleotide at the -2 position in the overhang, had a smaller effect (KD = 7.6E-7M)."|kinetic_conditions:pH=7.5, Temp=25C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/06/11	2014/10/16	rogid:I70gmzAJoBvK53kEZUaKOv/zshg83333	rogid:Wd7zI2kwfKLoHTrbfM9l98atQuw83333	intact-crc:3D8929A4DB4D013A	false	sufficient binding region:1-373	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06710	intact:EBI-2353751	intact:EBI-549140|uniprotkb:Q2MBV7|uniprotkb:Q47721|uniprotkb:A0A385XJC4|ensemblbacteria:AAC73572|ensemblbacteria:AYC08179|ensemblbacteria:BAE76249	-	psi-mi:dpo3x_ecoli(display_long)|uniprotkb:dnaX(gene name)|psi-mi:dnaX(display_short)|uniprotkb:dnaZ(gene name synonym)|uniprotkb:dnaZX(gene name synonym)|uniprotkb:b0470(locus name)|uniprotkb:JW0459(locus name)|uniprotkb:DNA polymerase III subunit gamma(gene name synonym)	psi-mi:ttgtgggtagataaatacag(display_short)|psi-mi:EBI-2353751(display_long)	psi-mi:"MI:0053"(fluorescence polarization spectroscopy)	Simonetta et al. (2009)	imex:IM-12185|pubmed:19450514	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2353743|imex:IM-12185-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0319"(deoxyribonucleic acid)	refseq:NP_415003.1|refseq:WP_000122013.1|dip:DIP-9464N|ensemblbacteria:AAC73572(transcript)|ensemblbacteria:AYC08179(transcript)|ensemblbacteria:b0470(gene)|ensemblbacteria:BAE76249(gene)|ensemblbacteria:BAE76249(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006260"(DNA replication)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0009360"(DNA polymerase III complex)|go:"GO:0017111"(nucleoside-triphosphatase activity)|go:"GO:0030337"(DNA polymerase processivity factor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043846"(DNA polymerase III, clamp loader complex)|interpro:IPR001270(Chaperonin clpA/B)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR008921(DNA polymerase III clamp loader subunit, C-terminal)|interpro:IPR012763(DNA polymerase III, subunits gamma and tau)|interpro:IPR021029|interpro:IPR022001|interpro:IPR022754|interpro:IPR027417|interpro:IPR038249|rcsb pdb:1JR3|rcsb pdb:1NJF|rcsb pdb:1NJG|rcsb pdb:1XXH|rcsb pdb:1XXI|rcsb pdb:2AYA|rcsb pdb:3GLF|rcsb pdb:3GLG|rcsb pdb:3GLH|rcsb pdb:3GLI|rcsb pdb:5FKU|rcsb pdb:5FKV	-	-	-	-	figure legend:Figs. 4B, 6B|kinetics:"KD for DNA binding = 1.8E-7M. Mutation of Lys 313 and Arg 248, which interact with the phosphate group of the nucleotide at the -1 position, increases the value of KD to 6.1 E-6M and 1.3 E-6M for the mutants, respectively. Mutation of Arg 252, which interacts with the phosphate group of the nucleotide at the -2 position in the overhang, had a smaller effect (KD = 7.6E-7M)."|kinetic_conditions:pH=7.5, Temp=25C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/06/11	2014/10/16	rogid:I70gmzAJoBvK53kEZUaKOv/zshg83333	crc64:865E0C94317E01E1	intact-crc:3D8929A4DB4D013A	false	sufficient binding region:1-373	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06710	intact:EBI-2353791	intact:EBI-549140|uniprotkb:Q2MBV7|uniprotkb:Q47721|uniprotkb:A0A385XJC4|ensemblbacteria:AAC73572|ensemblbacteria:AYC08179|ensemblbacteria:BAE76249	-	psi-mi:dpo3x_ecoli(display_long)|uniprotkb:dnaX(gene name)|psi-mi:dnaX(display_short)|uniprotkb:dnaZ(gene name synonym)|uniprotkb:dnaZX(gene name synonym)|uniprotkb:b0470(locus name)|uniprotkb:JW0459(locus name)|uniprotkb:DNA polymerase III subunit gamma(gene name synonym)	psi-mi:gggacgcacgcggcattcaa(display_short)|psi-mi:EBI-2353791(display_long)	psi-mi:"MI:0053"(fluorescence polarization spectroscopy)	Simonetta et al. (2009)	imex:IM-12185|pubmed:19450514	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2353794|imex:IM-12185-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0319"(deoxyribonucleic acid)	refseq:NP_415003.1|refseq:WP_000122013.1|dip:DIP-9464N|ensemblbacteria:AAC73572(transcript)|ensemblbacteria:AYC08179(transcript)|ensemblbacteria:b0470(gene)|ensemblbacteria:BAE76249(gene)|ensemblbacteria:BAE76249(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006260"(DNA replication)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0009360"(DNA polymerase III complex)|go:"GO:0017111"(nucleoside-triphosphatase activity)|go:"GO:0030337"(DNA polymerase processivity factor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043846"(DNA polymerase III, clamp loader complex)|interpro:IPR001270(Chaperonin clpA/B)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR008921(DNA polymerase III clamp loader subunit, C-terminal)|interpro:IPR012763(DNA polymerase III, subunits gamma and tau)|interpro:IPR021029|interpro:IPR022001|interpro:IPR022754|interpro:IPR027417|interpro:IPR038249|rcsb pdb:1JR3|rcsb pdb:1NJF|rcsb pdb:1NJG|rcsb pdb:1XXH|rcsb pdb:1XXI|rcsb pdb:2AYA|rcsb pdb:3GLF|rcsb pdb:3GLG|rcsb pdb:3GLH|rcsb pdb:3GLI|rcsb pdb:5FKU|rcsb pdb:5FKV	-	-	-	-	figure legend:Figs. 6B|kinetics:The values of the KD of DNA binding are 3.8E-7M and 1.8 E-5M in the presence and absence of Psi peptide, respectively.|kinetic_conditions:pH=7.5, Temp=25C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/06/11	2014/10/16	rogid:I70gmzAJoBvK53kEZUaKOv/zshg83333	crc64:B7ABD258A1E51976	intact-crc:444854EDB2F5A1EA	false	sufficient binding region:1-373	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06710	uniprotkb:P28630	intact:EBI-549140|uniprotkb:Q2MBV7|uniprotkb:Q47721|uniprotkb:A0A385XJC4|ensemblbacteria:AAC73572|ensemblbacteria:AYC08179|ensemblbacteria:BAE76249	intact:EBI-549153|ensemblbacteria:AAC73741|ensemblbacteria:BAA35287	psi-mi:dpo3x_ecoli(display_long)|uniprotkb:dnaX(gene name)|psi-mi:dnaX(display_short)|uniprotkb:dnaZ(gene name synonym)|uniprotkb:dnaZX(gene name synonym)|uniprotkb:b0470(locus name)|uniprotkb:JW0459(locus name)|uniprotkb:DNA polymerase III subunit gamma(gene name synonym)	psi-mi:hola_ecoli(display_long)|uniprotkb:b0640(locus name)|uniprotkb:holA(gene name)|psi-mi:holA(display_short)|uniprotkb:JW0635(locus name)	psi-mi:"MI:0053"(fluorescence polarization spectroscopy)	Simonetta et al. (2009)	imex:IM-12185|pubmed:19450514	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2353794|imex:IM-12185-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_415003.1|refseq:WP_000122013.1|dip:DIP-9464N|ensemblbacteria:AAC73572(transcript)|ensemblbacteria:AYC08179(transcript)|ensemblbacteria:b0470(gene)|ensemblbacteria:BAE76249(gene)|ensemblbacteria:BAE76249(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006260"(DNA replication)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0009360"(DNA polymerase III complex)|go:"GO:0017111"(nucleoside-triphosphatase activity)|go:"GO:0030337"(DNA polymerase processivity factor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043846"(DNA polymerase III, clamp loader complex)|interpro:IPR001270(Chaperonin clpA/B)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR008921(DNA polymerase III clamp loader subunit, C-terminal)|interpro:IPR012763(DNA polymerase III, subunits gamma and tau)|interpro:IPR021029|interpro:IPR022001|interpro:IPR022754|interpro:IPR027417|interpro:IPR038249|rcsb pdb:1JR3|rcsb pdb:1NJF|rcsb pdb:1NJG|rcsb pdb:1XXH|rcsb pdb:1XXI|rcsb pdb:2AYA|rcsb pdb:3GLF|rcsb pdb:3GLG|rcsb pdb:3GLH|rcsb pdb:3GLI|rcsb pdb:5FKU|rcsb pdb:5FKV	refseq:NP_415173.1|refseq:WP_000620535.1|dip:DIP-9931N|rcsb pdb:3GLG|rcsb pdb:3GLH|rcsb pdb:3GLI|ensemblbacteria:AAC73741(transcript)|ensemblbacteria:b0640(gene)|ensemblbacteria:BAA35287(gene)|ensemblbacteria:BAA35287(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0009360"(DNA polymerase III complex)|interpro:IPR005790(DNA polymerase III, delta subunit)|interpro:IPR008921(DNA polymerase III clamp loader subunit, C-terminal)|interpro:IPR010372(DNA polymerase III, delta)|interpro:IPR027417|interpro:IPR032780|rcsb pdb:1JQJ|rcsb pdb:1JQL|rcsb pdb:1JR3|rcsb pdb:1XXH|rcsb pdb:1XXI|rcsb pdb:3GLF	-	-	crc64:87239A678FE16BE2	figure legend:Figs. 6B|kinetics:The values of the KD of DNA binding are 3.8E-7M and 1.8 E-5M in the presence and absence of Psi peptide, respectively.|kinetic_conditions:pH=7.5, Temp=25C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/06/11	2014/10/16	rogid:I70gmzAJoBvK53kEZUaKOv/zshg83333	rogid:xMcC78PZeDNSqwRnRtbA31N1xMg83333	intact-crc:444854EDB2F5A1EA	false	sufficient binding region:1-373	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06710	uniprotkb:P28631	intact:EBI-549140|uniprotkb:Q2MBV7|uniprotkb:Q47721|uniprotkb:A0A385XJC4|ensemblbacteria:AAC73572|ensemblbacteria:AYC08179|ensemblbacteria:BAE76249	intact:EBI-549161|ensemblbacteria:BAA35906|ensemblbacteria:AAC74183	psi-mi:dpo3x_ecoli(display_long)|uniprotkb:dnaX(gene name)|psi-mi:dnaX(display_short)|uniprotkb:dnaZ(gene name synonym)|uniprotkb:dnaZX(gene name synonym)|uniprotkb:b0470(locus name)|uniprotkb:JW0459(locus name)|uniprotkb:DNA polymerase III subunit gamma(gene name synonym)	psi-mi:holb_ecoli(display_long)|uniprotkb:holB(gene name)|psi-mi:holB(display_short)|uniprotkb:b1099(locus name)|uniprotkb:JW1085(locus name)	psi-mi:"MI:0053"(fluorescence polarization spectroscopy)	Simonetta et al. (2009)	imex:IM-12185|pubmed:19450514	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2353794|imex:IM-12185-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_415003.1|refseq:WP_000122013.1|dip:DIP-9464N|ensemblbacteria:AAC73572(transcript)|ensemblbacteria:AYC08179(transcript)|ensemblbacteria:b0470(gene)|ensemblbacteria:BAE76249(gene)|ensemblbacteria:BAE76249(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006260"(DNA replication)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0009360"(DNA polymerase III complex)|go:"GO:0017111"(nucleoside-triphosphatase activity)|go:"GO:0030337"(DNA polymerase processivity factor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043846"(DNA polymerase III, clamp loader complex)|interpro:IPR001270(Chaperonin clpA/B)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR008921(DNA polymerase III clamp loader subunit, C-terminal)|interpro:IPR012763(DNA polymerase III, subunits gamma and tau)|interpro:IPR021029|interpro:IPR022001|interpro:IPR022754|interpro:IPR027417|interpro:IPR038249|rcsb pdb:1JR3|rcsb pdb:1NJF|rcsb pdb:1NJG|rcsb pdb:1XXH|rcsb pdb:1XXI|rcsb pdb:2AYA|rcsb pdb:3GLF|rcsb pdb:3GLG|rcsb pdb:3GLH|rcsb pdb:3GLI|rcsb pdb:5FKU|rcsb pdb:5FKV	refseq:NP_415617.1|refseq:WP_001267956.1|dip:DIP-9932N|ensemblbacteria:BAA35906(gene)|ensemblbacteria:BAA35906(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0008408"(3'-5' exonuclease activity)|go:"GO:0009360"(DNA polymerase III complex)|interpro:IPR004622(DNA polymerase III, delta prime subunit)|interpro:IPR008921(DNA polymerase III clamp loader subunit, C-terminal)|interpro:IPR015199(DNA polymerase III, delta subunit, C-terminal)|interpro:IPR027417|rcsb pdb:1A5T|rcsb pdb:1JR3|rcsb pdb:1XXH|ensemblbacteria:AAC74183(transcript)|ensemblbacteria:b1099(gene)|rcsb pdb:1XXI|rcsb pdb:3GLF|rcsb pdb:3GLH|rcsb pdb:3GLI|rcsb pdb:3GLG	-	-	-	figure legend:Figs. 6B|kinetics:The values of the KD of DNA binding are 3.8E-7M and 1.8 E-5M in the presence and absence of Psi peptide, respectively.|kinetic_conditions:pH=7.5, Temp=25C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/06/11	2014/10/16	rogid:I70gmzAJoBvK53kEZUaKOv/zshg83333	rogid:Wd7zI2kwfKLoHTrbfM9l98atQuw83333	intact-crc:444854EDB2F5A1EA	false	sufficient binding region:1-373	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06710	uniprotkb:P28632	intact:EBI-549140|uniprotkb:Q2MBV7|uniprotkb:Q47721|uniprotkb:A0A385XJC4|ensemblbacteria:AAC73572|ensemblbacteria:AYC08179|ensemblbacteria:BAE76249	intact:EBI-549176|uniprotkb:Q2M5U6|ensemblbacteria:AAC77325|ensemblbacteria:BAE78360	psi-mi:dpo3x_ecoli(display_long)|uniprotkb:dnaX(gene name)|psi-mi:dnaX(display_short)|uniprotkb:dnaZ(gene name synonym)|uniprotkb:dnaZX(gene name synonym)|uniprotkb:b0470(locus name)|uniprotkb:JW0459(locus name)|uniprotkb:DNA polymerase III subunit gamma(gene name synonym)	psi-mi:hold_ecoli(display_long)|uniprotkb:holD(gene name)|psi-mi:holD(display_short)|uniprotkb:b4372(locus name)|uniprotkb:JW4334(locus name)	psi-mi:"MI:0053"(fluorescence polarization spectroscopy)	Simonetta et al. (2009)	imex:IM-12185|pubmed:19450514	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2353794|imex:IM-12185-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_415003.1|refseq:WP_000122013.1|dip:DIP-9464N|ensemblbacteria:AAC73572(transcript)|ensemblbacteria:AYC08179(transcript)|ensemblbacteria:b0470(gene)|ensemblbacteria:BAE76249(gene)|ensemblbacteria:BAE76249(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006260"(DNA replication)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0009360"(DNA polymerase III complex)|go:"GO:0017111"(nucleoside-triphosphatase activity)|go:"GO:0030337"(DNA polymerase processivity factor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043846"(DNA polymerase III, clamp loader complex)|interpro:IPR001270(Chaperonin clpA/B)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR008921(DNA polymerase III clamp loader subunit, C-terminal)|interpro:IPR012763(DNA polymerase III, subunits gamma and tau)|interpro:IPR021029|interpro:IPR022001|interpro:IPR022754|interpro:IPR027417|interpro:IPR038249|rcsb pdb:1JR3|rcsb pdb:1NJF|rcsb pdb:1NJG|rcsb pdb:1XXH|rcsb pdb:1XXI|rcsb pdb:2AYA|rcsb pdb:3GLF|rcsb pdb:3GLG|rcsb pdb:3GLH|rcsb pdb:3GLI|rcsb pdb:5FKU|rcsb pdb:5FKV	refseq:NP_418789.1|refseq:WP_000204012.1|dip:DIP-9934N|ensemblbacteria:AAC77325(transcript)|ensemblbacteria:b4372(gene)|ensemblbacteria:BAE78360(gene)|ensemblbacteria:BAE78360(transcript)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0006260"(DNA replication)|go:"GO:0008408"(3'-5' exonuclease activity)|go:"GO:0009314"(response to radiation)|interpro:IPR004615(DNA polymerase III, psi subunit)|interpro:IPR018382|interpro:IPR036654|rcsb pdb:1EM8|rcsb pdb:3GLI|rcsb pdb:3SXU	-	-	-	figure legend:Figs. 6B|kinetics:The values of the KD of DNA binding are 3.8E-7M and 1.8 E-5M in the presence and absence of Psi peptide, respectively.|kinetic_conditions:pH=7.5, Temp=25C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/06/11	2014/10/16	rogid:I70gmzAJoBvK53kEZUaKOv/zshg83333	rogid:w1FQAOKGyqkQNCRGnGeAoy5Odbk83333	intact-crc:444854EDB2F5A1EA	false	sufficient binding region:1-373	sufficient binding region:2-28	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06710	intact:EBI-2353751	intact:EBI-549140|uniprotkb:Q2MBV7|uniprotkb:Q47721|uniprotkb:A0A385XJC4|ensemblbacteria:AAC73572|ensemblbacteria:AYC08179|ensemblbacteria:BAE76249	-	psi-mi:dpo3x_ecoli(display_long)|uniprotkb:dnaX(gene name)|psi-mi:dnaX(display_short)|uniprotkb:dnaZ(gene name synonym)|uniprotkb:dnaZX(gene name synonym)|uniprotkb:b0470(locus name)|uniprotkb:JW0459(locus name)|uniprotkb:DNA polymerase III subunit gamma(gene name synonym)	psi-mi:ttgtgggtagataaatacag(display_short)|psi-mi:EBI-2353751(display_long)	psi-mi:"MI:0053"(fluorescence polarization spectroscopy)	Simonetta et al. (2009)	imex:IM-12185|pubmed:19450514	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2353794|imex:IM-12185-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0319"(deoxyribonucleic acid)	refseq:NP_415003.1|refseq:WP_000122013.1|dip:DIP-9464N|ensemblbacteria:AAC73572(transcript)|ensemblbacteria:AYC08179(transcript)|ensemblbacteria:b0470(gene)|ensemblbacteria:BAE76249(gene)|ensemblbacteria:BAE76249(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006260"(DNA replication)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0009360"(DNA polymerase III complex)|go:"GO:0017111"(nucleoside-triphosphatase activity)|go:"GO:0030337"(DNA polymerase processivity factor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043846"(DNA polymerase III, clamp loader complex)|interpro:IPR001270(Chaperonin clpA/B)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR008921(DNA polymerase III clamp loader subunit, C-terminal)|interpro:IPR012763(DNA polymerase III, subunits gamma and tau)|interpro:IPR021029|interpro:IPR022001|interpro:IPR022754|interpro:IPR027417|interpro:IPR038249|rcsb pdb:1JR3|rcsb pdb:1NJF|rcsb pdb:1NJG|rcsb pdb:1XXH|rcsb pdb:1XXI|rcsb pdb:2AYA|rcsb pdb:3GLF|rcsb pdb:3GLG|rcsb pdb:3GLH|rcsb pdb:3GLI|rcsb pdb:5FKU|rcsb pdb:5FKV	-	-	-	-	figure legend:Figs. 6B|kinetics:The values of the KD of DNA binding are 3.8E-7M and 1.8 E-5M in the presence and absence of Psi peptide, respectively.|kinetic_conditions:pH=7.5, Temp=25C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/06/11	2014/10/16	rogid:I70gmzAJoBvK53kEZUaKOv/zshg83333	crc64:865E0C94317E01E1	intact-crc:444854EDB2F5A1EA	false	sufficient binding region:1-373	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06710	uniprotkb:P28630	intact:EBI-549140|uniprotkb:Q2MBV7|uniprotkb:Q47721|uniprotkb:A0A385XJC4|ensemblbacteria:AAC73572|ensemblbacteria:AYC08179|ensemblbacteria:BAE76249	intact:EBI-549153|ensemblbacteria:AAC73741|ensemblbacteria:BAA35287	psi-mi:dpo3x_ecoli(display_long)|uniprotkb:dnaX(gene name)|psi-mi:dnaX(display_short)|uniprotkb:dnaZ(gene name synonym)|uniprotkb:dnaZX(gene name synonym)|uniprotkb:b0470(locus name)|uniprotkb:JW0459(locus name)|uniprotkb:DNA polymerase III subunit gamma(gene name synonym)	psi-mi:hola_ecoli(display_long)|uniprotkb:b0640(locus name)|uniprotkb:holA(gene name)|psi-mi:holA(display_short)|uniprotkb:JW0635(locus name)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Simonetta et al. (2009)	imex:IM-12185|pubmed:19450514	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2353769|imex:IM-12185-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_415003.1|refseq:WP_000122013.1|dip:DIP-9464N|ensemblbacteria:AAC73572(transcript)|ensemblbacteria:AYC08179(transcript)|ensemblbacteria:b0470(gene)|ensemblbacteria:BAE76249(gene)|ensemblbacteria:BAE76249(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006260"(DNA replication)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0009360"(DNA polymerase III complex)|go:"GO:0017111"(nucleoside-triphosphatase activity)|go:"GO:0030337"(DNA polymerase processivity factor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043846"(DNA polymerase III, clamp loader complex)|interpro:IPR001270(Chaperonin clpA/B)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR008921(DNA polymerase III clamp loader subunit, C-terminal)|interpro:IPR012763(DNA polymerase III, subunits gamma and tau)|interpro:IPR021029|interpro:IPR022001|interpro:IPR022754|interpro:IPR027417|interpro:IPR038249|rcsb pdb:1JR3|rcsb pdb:1NJF|rcsb pdb:1NJG|rcsb pdb:1XXH|rcsb pdb:1XXI|rcsb pdb:2AYA|rcsb pdb:3GLF|rcsb pdb:3GLG|rcsb pdb:3GLH|rcsb pdb:3GLI|rcsb pdb:5FKU|rcsb pdb:5FKV	refseq:NP_415173.1|refseq:WP_000620535.1|dip:DIP-9931N|rcsb pdb:3GLG|rcsb pdb:3GLH|rcsb pdb:3GLI|ensemblbacteria:AAC73741(transcript)|ensemblbacteria:b0640(gene)|ensemblbacteria:BAA35287(gene)|ensemblbacteria:BAA35287(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0009360"(DNA polymerase III complex)|interpro:IPR005790(DNA polymerase III, delta subunit)|interpro:IPR008921(DNA polymerase III clamp loader subunit, C-terminal)|interpro:IPR010372(DNA polymerase III, delta)|interpro:IPR027417|interpro:IPR032780|rcsb pdb:1JQJ|rcsb pdb:1JQL|rcsb pdb:1JR3|rcsb pdb:1XXH|rcsb pdb:1XXI|rcsb pdb:3GLF	psi-mi:"MI:0469"(intact)	-	crc64:87239A678FE16BE2	figure legend:Fig. 6A|comment:"Stoichiometry of binding of clamp loader complex to holD peptide is 1:1"|kinetics:"Kd=7E-9M (clamp loader binding to holD peptide)."|kinetics:pH=7.5, Temp=25C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/06/11	2014/10/16	rogid:I70gmzAJoBvK53kEZUaKOv/zshg83333	rogid:xMcC78PZeDNSqwRnRtbA31N1xMg83333	intact-crc:C617B08501EF7F83|rigid:DaNZ0fQ/o9CVijNMPfhum9+CnMg	false	his tag:n-n|sufficient binding region:1-373	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06710	uniprotkb:P28631	intact:EBI-549140|uniprotkb:Q2MBV7|uniprotkb:Q47721|uniprotkb:A0A385XJC4|ensemblbacteria:AAC73572|ensemblbacteria:AYC08179|ensemblbacteria:BAE76249	intact:EBI-549161|ensemblbacteria:BAA35906|ensemblbacteria:AAC74183	psi-mi:dpo3x_ecoli(display_long)|uniprotkb:dnaX(gene name)|psi-mi:dnaX(display_short)|uniprotkb:dnaZ(gene name synonym)|uniprotkb:dnaZX(gene name synonym)|uniprotkb:b0470(locus name)|uniprotkb:JW0459(locus name)|uniprotkb:DNA polymerase III subunit gamma(gene name synonym)	psi-mi:holb_ecoli(display_long)|uniprotkb:holB(gene name)|psi-mi:holB(display_short)|uniprotkb:b1099(locus name)|uniprotkb:JW1085(locus name)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Simonetta et al. (2009)	imex:IM-12185|pubmed:19450514	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2353769|imex:IM-12185-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_415003.1|refseq:WP_000122013.1|dip:DIP-9464N|ensemblbacteria:AAC73572(transcript)|ensemblbacteria:AYC08179(transcript)|ensemblbacteria:b0470(gene)|ensemblbacteria:BAE76249(gene)|ensemblbacteria:BAE76249(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006260"(DNA replication)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0009360"(DNA polymerase III complex)|go:"GO:0017111"(nucleoside-triphosphatase activity)|go:"GO:0030337"(DNA polymerase processivity factor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043846"(DNA polymerase III, clamp loader complex)|interpro:IPR001270(Chaperonin clpA/B)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR008921(DNA polymerase III clamp loader subunit, C-terminal)|interpro:IPR012763(DNA polymerase III, subunits gamma and tau)|interpro:IPR021029|interpro:IPR022001|interpro:IPR022754|interpro:IPR027417|interpro:IPR038249|rcsb pdb:1JR3|rcsb pdb:1NJF|rcsb pdb:1NJG|rcsb pdb:1XXH|rcsb pdb:1XXI|rcsb pdb:2AYA|rcsb pdb:3GLF|rcsb pdb:3GLG|rcsb pdb:3GLH|rcsb pdb:3GLI|rcsb pdb:5FKU|rcsb pdb:5FKV	refseq:NP_415617.1|refseq:WP_001267956.1|dip:DIP-9932N|ensemblbacteria:BAA35906(gene)|ensemblbacteria:BAA35906(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0008408"(3'-5' exonuclease activity)|go:"GO:0009360"(DNA polymerase III complex)|interpro:IPR004622(DNA polymerase III, delta prime subunit)|interpro:IPR008921(DNA polymerase III clamp loader subunit, C-terminal)|interpro:IPR015199(DNA polymerase III, delta subunit, C-terminal)|interpro:IPR027417|rcsb pdb:1A5T|rcsb pdb:1JR3|rcsb pdb:1XXH|ensemblbacteria:AAC74183(transcript)|ensemblbacteria:b1099(gene)|rcsb pdb:1XXI|rcsb pdb:3GLF|rcsb pdb:3GLH|rcsb pdb:3GLI|rcsb pdb:3GLG	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 6A|comment:"Stoichiometry of binding of clamp loader complex to holD peptide is 1:1"|kinetics:"Kd=7E-9M (clamp loader binding to holD peptide)."|kinetics:pH=7.5, Temp=25C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/06/11	2014/10/16	rogid:I70gmzAJoBvK53kEZUaKOv/zshg83333	rogid:Wd7zI2kwfKLoHTrbfM9l98atQuw83333	intact-crc:C617B08501EF7F83|rigid:DaNZ0fQ/o9CVijNMPfhum9+CnMg	false	his tag:n-n|sufficient binding region:1-373	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P06710	uniprotkb:P28632	intact:EBI-549140|uniprotkb:Q2MBV7|uniprotkb:Q47721|uniprotkb:A0A385XJC4|ensemblbacteria:AAC73572|ensemblbacteria:AYC08179|ensemblbacteria:BAE76249	intact:EBI-549176|uniprotkb:Q2M5U6|ensemblbacteria:AAC77325|ensemblbacteria:BAE78360	psi-mi:dpo3x_ecoli(display_long)|uniprotkb:dnaX(gene name)|psi-mi:dnaX(display_short)|uniprotkb:dnaZ(gene name synonym)|uniprotkb:dnaZX(gene name synonym)|uniprotkb:b0470(locus name)|uniprotkb:JW0459(locus name)|uniprotkb:DNA polymerase III subunit gamma(gene name synonym)	psi-mi:hold_ecoli(display_long)|uniprotkb:holD(gene name)|psi-mi:holD(display_short)|uniprotkb:b4372(locus name)|uniprotkb:JW4334(locus name)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Simonetta et al. (2009)	imex:IM-12185|pubmed:19450514	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	taxid:83333(ecoli)|taxid:83333("Escherichia coli (strain K12)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2353769|imex:IM-12185-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_415003.1|refseq:WP_000122013.1|dip:DIP-9464N|ensemblbacteria:AAC73572(transcript)|ensemblbacteria:AYC08179(transcript)|ensemblbacteria:b0470(gene)|ensemblbacteria:BAE76249(gene)|ensemblbacteria:BAE76249(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0006260"(DNA replication)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0009360"(DNA polymerase III complex)|go:"GO:0017111"(nucleoside-triphosphatase activity)|go:"GO:0030337"(DNA polymerase processivity factor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043846"(DNA polymerase III, clamp loader complex)|interpro:IPR001270(Chaperonin clpA/B)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR008921(DNA polymerase III clamp loader subunit, C-terminal)|interpro:IPR012763(DNA polymerase III, subunits gamma and tau)|interpro:IPR021029|interpro:IPR022001|interpro:IPR022754|interpro:IPR027417|interpro:IPR038249|rcsb pdb:1JR3|rcsb pdb:1NJF|rcsb pdb:1NJG|rcsb pdb:1XXH|rcsb pdb:1XXI|rcsb pdb:2AYA|rcsb pdb:3GLF|rcsb pdb:3GLG|rcsb pdb:3GLH|rcsb pdb:3GLI|rcsb pdb:5FKU|rcsb pdb:5FKV	refseq:NP_418789.1|refseq:WP_000204012.1|dip:DIP-9934N|ensemblbacteria:AAC77325(transcript)|ensemblbacteria:b4372(gene)|ensemblbacteria:BAE78360(gene)|ensemblbacteria:BAE78360(transcript)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0006260"(DNA replication)|go:"GO:0008408"(3'-5' exonuclease activity)|go:"GO:0009314"(response to radiation)|interpro:IPR004615(DNA polymerase III, psi subunit)|interpro:IPR018382|interpro:IPR036654|rcsb pdb:1EM8|rcsb pdb:3GLI|rcsb pdb:3SXU	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 6A|comment:"Stoichiometry of binding of clamp loader complex to holD peptide is 1:1"|kinetics:"Kd=7E-9M (clamp loader binding to holD peptide)."|kinetics:pH=7.5, Temp=25C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/06/11	2014/10/16	rogid:I70gmzAJoBvK53kEZUaKOv/zshg83333	rogid:w1FQAOKGyqkQNCRGnGeAoy5Odbk83333	intact-crc:C617B08501EF7F83|rigid:DaNZ0fQ/o9CVijNMPfhum9+CnMg	false	his tag:n-n|sufficient binding region:1-373	sufficient binding region:2-28|mutation decreasing interaction:17-17	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)