#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P0C605	uniprotkb:O35607	intact:EBI-6991999|ensembl:ENSMUSP00000067576|intact:MINT-7289393|uniprotkb:Q9Z0Z0|uniprotkb:Q14DK6|intact:UNK-5561184	intact:EBI-527224|ensembl:ENSMUSP00000084701	psi-mi:kgp1_mouse(display_long)|uniprotkb:Prkg1(gene name)|psi-mi:Prkg1(display_short)|uniprotkb:Prkgr1a(gene name synonym)|uniprotkb:Prkg1b(gene name synonym)|uniprotkb:Prkgr1b(gene name synonym)|uniprotkb:cGMP-dependent protein kinase I(gene name synonym)	psi-mi:bmpr2_mouse(display_long)|uniprotkb:Bone morphogenetic protein receptor type II(gene name synonym)|uniprotkb:BRK-3(gene name synonym)|uniprotkb:Bmpr2(gene name)|psi-mi:Bmpr2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Schwappacher et al. (2009)	pubmed:19424179|imex:IM-13879|mint:MINT-7289369|doi:10.1038/emboj.2009.103	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-6991993|mint:MINT-7289427|imex:IM-13879-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006526831.1|ensembl:ENSMUSG00000052920(gene)|ensembl:ENSMUST00000065067(transcript)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0001764"(neuron migration)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004692"(cGMP-dependent protein kinase activity)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0010920"(negative regulation of inositol phosphate biosynthetic process)|go:"GO:0014050"(negative regulation of glutamate secretion)|go:"GO:0014912"(negative regulation of smooth muscle cell migration)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0019934"(cGMP-mediated signaling)|go:"GO:0030553"(cGMP binding)|go:"GO:0030900"(forebrain development)|go:"GO:0042311"(vasodilation)|go:"GO:0042753"(positive regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0045822"(negative regulation of heart contraction)|go:"GO:0045986"(negative regulation of smooth muscle contraction)|go:"GO:0048273"(mitogen-activated protein kinase p38 binding)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0061049"(cell growth involved in cardiac muscle cell development)|go:"GO:0090331"(negative regulation of platelet aggregation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902608"(positive regulation of large conductance calcium-activated potassium channel activity)|go:"GO:1904753"(negative regulation of vascular associated smooth muscle cell migration)|go:"GO:2000224"(regulation of testosterone biosynthetic process)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR002374(cGMP-dependent protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR018488|interpro:IPR018490|interpro:IPR031831|interpro:IPR035014|mint:P0C605|reactome:R-MMU-392517|reactome:R-MMU-418457|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|refseq:NP_001013855.1|refseq:NP_035290.1|dip:DIP-29981N|mint:MINT-7289430(identity)	ensembl:ENSMUSG00000067336(gene)|ensembl:ENSMUST00000087435(transcript)|go:"GO:0001568"(blood vessel development)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001893"(maternal placenta development)|go:"GO:0001935"(endothelial cell proliferation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001946"(lymphangiogenesis)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002063"(chondrocyte development)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003176"(aortic valve development)|go:"GO:0003177"(pulmonary valve development)|go:"GO:0003183"(mitral valve morphogenesis)|go:"GO:0003186"(tricuspid valve morphogenesis)|go:"GO:0003197"(endocardial cushion development)|go:"GO:0003252"(negative regulation of cell proliferation involved in heart valve morphogenesis)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005024"(transforming growth factor beta-activated receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005912"(adherens junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007178"(transmembrane receptor protein serine/threonine kinase signaling pathway)|go:"GO:0007420"(brain development)|go:"GO:0009267"(cellular response to starvation)|refseq:NP_031587.1|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014916"(regulation of lung blood pressure)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019211"(phosphatase activator activity)|go:"GO:0019838"(growth factor binding)|go:"GO:0030166"(proteoglycan biosynthetic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0030546"(signaling receptor activator activity)|go:"GO:0036122"(BMP binding)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043235"(receptor complex)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045296"(cadherin binding)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045778"(positive regulation of ossification)|go:"GO:0045906"(negative regulation of vasoconstriction)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048286"(lung alveolus development)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0048842"(positive regulation of axon extension involved in axon guidance)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0060173"(limb development)|go:"GO:0060350"(endochondral bone morphogenesis)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060413"(atrial septum morphogenesis)|go:"GO:0060836"(lymphatic endothelial cell differentiation)|go:"GO:0060840"(artery development)|go:"GO:0060841"(venous blood vessel development)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0061298"(retina vasculature development in camera-type eye)|go:"GO:0061626"(pharyngeal arch artery morphogenesis)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0098821"(BMP receptor activity)|go:"GO:0140537"(transcription regulator activator activity)|go:"GO:1902731"(negative regulation of chondrocyte proliferation)|go:"GO:1905314"(semi-lunar valve development)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000279"(negative regulation of DNA biosynthetic process)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000333(Activin type II receptor)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015770(Bone morphogenic protein type II receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:O35607|reactome:R-MMU-201451|mint:MINT-7289429(identity)	-	comment:mint	-	figure legend:F1A|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-c2c12)|taxid:10090(Mouse C3H muscle myoblast)	-	2009/10/08	2014/10/16	rogid:P+szNlUos2Nnfev1xiY4J5ztVTQ10090	rogid:4Dbgj6TEhtrX/9jydmufYNfEh1M10090	intact-crc:60906C0FA4EAA2E3|rigid:XpLnjBUjFZc+5bempwU09bp4378	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P0C605	uniprotkb:P70340	intact:EBI-6991999|ensembl:ENSMUSP00000067576|intact:MINT-7289393|uniprotkb:Q9Z0Z0|uniprotkb:Q14DK6|intact:UNK-5561184	intact:EBI-6992047|ensembl:ENSMUSP00000071035|uniprotkb:Q6GT95|uniprotkb:P70442|uniprotkb:Q9CYK6|intact:MINT-99213	psi-mi:kgp1_mouse(display_long)|uniprotkb:Prkg1(gene name)|psi-mi:Prkg1(display_short)|uniprotkb:Prkgr1a(gene name synonym)|uniprotkb:Prkg1b(gene name synonym)|uniprotkb:Prkgr1b(gene name synonym)|uniprotkb:cGMP-dependent protein kinase I(gene name synonym)	psi-mi:smad1_mouse(display_long)|uniprotkb:Smad1(gene name)|psi-mi:Smad1(display_short)|uniprotkb:Madh1(gene name synonym)|uniprotkb:Madr1(gene name synonym)|uniprotkb:Mothers-against-DPP-related 1(gene name synonym)|uniprotkb:Dwarfin-A(gene name synonym)|uniprotkb:SMAD family member 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Schwappacher et al. (2009)	pubmed:19424179|imex:IM-13879|mint:MINT-7289369|doi:10.1038/emboj.2009.103	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-6992107|mint:MINT-7289511|imex:IM-13879-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006526831.1|ensembl:ENSMUSG00000052920(gene)|ensembl:ENSMUST00000065067(transcript)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0001764"(neuron migration)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004692"(cGMP-dependent protein kinase activity)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0010920"(negative regulation of inositol phosphate biosynthetic process)|go:"GO:0014050"(negative regulation of glutamate secretion)|go:"GO:0014912"(negative regulation of smooth muscle cell migration)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0019934"(cGMP-mediated signaling)|go:"GO:0030553"(cGMP binding)|go:"GO:0030900"(forebrain development)|go:"GO:0042311"(vasodilation)|go:"GO:0042753"(positive regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0045822"(negative regulation of heart contraction)|go:"GO:0045986"(negative regulation of smooth muscle contraction)|go:"GO:0048273"(mitogen-activated protein kinase p38 binding)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0061049"(cell growth involved in cardiac muscle cell development)|go:"GO:0090331"(negative regulation of platelet aggregation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902608"(positive regulation of large conductance calcium-activated potassium channel activity)|go:"GO:1904753"(negative regulation of vascular associated smooth muscle cell migration)|go:"GO:2000224"(regulation of testosterone biosynthetic process)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR002374(cGMP-dependent protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR018488|interpro:IPR018490|interpro:IPR031831|interpro:IPR035014|mint:P0C605|reactome:R-MMU-392517|reactome:R-MMU-418457|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|refseq:NP_001013855.1|refseq:NP_035290.1|dip:DIP-29981N|mint:MINT-7289516(identity)	refseq:XP_006530809.1|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0017151"(DEAD/H-box RNA helicase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030901"(midbrain development)|go:"GO:0006954"(inflammatory response)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0030902"(hindbrain development)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042493"|go:"GO:0042592"(homeostatic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0051216"(cartilage development)|go:"GO:0060038"(cardiac muscle cell proliferation)|go:"GO:0060348"(bone development)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0007276"(gamete generation)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0070410"(co-SMAD binding)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|mint:P70340|rcsb pdb:3KMP|reactome:R-MMU-201451|reactome:R-MMU-5689880|reactome:R-MMU-8941326|ensembl:ENSMUSG00000031681(gene)|ensembl:ENSMUST00000066091(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0002051"(osteoblast fate commitment)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006468"(protein phosphorylation)|refseq:NP_032565.2|mint:MINT-7289521(identity)	-	comment:mint	comment:mint|function:"Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD1 is a receptor-regulated SMAD (R-SMAD) (By similarity). May play a role in the initiation and maintenance of spermatogenesis"	figure legend:F6B|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-c2c12)|taxid:10090(Mouse C3H muscle myoblast)	-	2009/10/08	2014/10/16	rogid:P+szNlUos2Nnfev1xiY4J5ztVTQ10090	rogid:D3Mhh31YZUsykSUfzewNuy8NyrY10090	intact-crc:B215A909D40B442F|rigid:FDUDjy2V7/ExhYaUY6cuSMTDz04	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P0C605	uniprotkb:P97471	intact:EBI-6991999|ensembl:ENSMUSP00000067576|intact:MINT-7289393|uniprotkb:Q9Z0Z0|uniprotkb:Q14DK6|intact:UNK-5561184	intact:EBI-5259270|uniprotkb:Q6GTP6|uniprotkb:Q9CW56|ensembl:ENSMUSP00000025393|ensembl:ENSMUSP00000110589	psi-mi:kgp1_mouse(display_long)|uniprotkb:Prkg1(gene name)|psi-mi:Prkg1(display_short)|uniprotkb:Prkgr1a(gene name synonym)|uniprotkb:Prkg1b(gene name synonym)|uniprotkb:Prkgr1b(gene name synonym)|uniprotkb:cGMP-dependent protein kinase I(gene name synonym)	psi-mi:smad4_mouse(display_long)|uniprotkb:Smad4(gene name)|psi-mi:Smad4(display_short)|uniprotkb:Dpc4(gene name synonym)|uniprotkb:Madh4(gene name synonym)|uniprotkb:Deletion target in pancreatic carcinoma 4 homolog(gene name synonym)|uniprotkb:SMAD family member 4(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Schwappacher et al. (2009)	pubmed:19424179|imex:IM-13879|mint:MINT-7289369|doi:10.1038/emboj.2009.103	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-6992107|mint:MINT-7289511|imex:IM-13879-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006526831.1|ensembl:ENSMUSG00000052920(gene)|ensembl:ENSMUST00000065067(transcript)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0001764"(neuron migration)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004692"(cGMP-dependent protein kinase activity)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0010920"(negative regulation of inositol phosphate biosynthetic process)|go:"GO:0014050"(negative regulation of glutamate secretion)|go:"GO:0014912"(negative regulation of smooth muscle cell migration)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0019934"(cGMP-mediated signaling)|go:"GO:0030553"(cGMP binding)|go:"GO:0030900"(forebrain development)|go:"GO:0042311"(vasodilation)|go:"GO:0042753"(positive regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0045822"(negative regulation of heart contraction)|go:"GO:0045986"(negative regulation of smooth muscle contraction)|go:"GO:0048273"(mitogen-activated protein kinase p38 binding)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0061049"(cell growth involved in cardiac muscle cell development)|go:"GO:0090331"(negative regulation of platelet aggregation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902608"(positive regulation of large conductance calcium-activated potassium channel activity)|go:"GO:1904753"(negative regulation of vascular associated smooth muscle cell migration)|go:"GO:2000224"(regulation of testosterone biosynthetic process)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR002374(cGMP-dependent protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR018488|interpro:IPR018490|interpro:IPR031831|interpro:IPR035014|mint:P0C605|reactome:R-MMU-392517|reactome:R-MMU-418457|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|refseq:NP_001013855.1|refseq:NP_035290.1|dip:DIP-29981N|mint:MINT-7289516(identity)	refseq:NP_032566.2|dip:DIP-29718N|ensembl:ENSMUSG00000024515(gene)|ensembl:ENSMUST00000025393(transcript)|ensembl:ENSMUST00000114939(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0001822"(kidney development)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003190"(atrioventricular valve formation)|go:"GO:0003198"(epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:0003220"(left ventricular cardiac muscle tissue morphogenesis)|go:"GO:0003251"(positive regulation of cell proliferation involved in heart valve morphogenesis)|go:"GO:0003279"(cardiac septum development)|go:"GO:0003360"(brainstem development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005518"(collagen binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0007369"(gastrulation)|go:"GO:0007411"(axon guidance)|go:"GO:0007492"(endoderm development)|go:"GO:0007498"(mesoderm development)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008584"(male gonad development)|go:"GO:0008585"(female gonad development)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0014033"(neural crest cell differentiation)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030154"(cell differentiation)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0031005"(filamin binding)|go:"GO:0032444"(activin responsive factor complex)|go:"GO:0032525"(somite rostral/caudal axis specification)|go:"GO:0032909"(regulation of transforming growth factor beta2 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033686"(positive regulation of luteinizing hormone secretion)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036302"(atrioventricular canal development)|go:"GO:0042060"(wound healing)|go:"GO:0042118"(endothelial cell activation)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043199"(sulfate binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0046881"(positive regulation of follicle-stimulating hormone secretion)|go:"GO:0048382"(mesendoderm development)|go:"GO:0048589"(developmental growth)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048729"(tissue morphogenesis)|go:"GO:0048733"(sebaceous gland development)|go:"GO:0048859"(formation of anatomical boundary)|go:"GO:0051098"(regulation of binding)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051797"(regulation of hair follicle development)|go:"GO:0060065"(uterus development)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0060956"(endocardial cell differentiation)|go:"GO:0061040"(female gonad morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0062009"(secondary palate development)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0071141"(SMAD protein complex)|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071559"(response to transforming growth factor beta)|go:"GO:0072133"(metanephric mesenchyme morphogenesis)|go:"GO:0072134"(nephrogenic mesenchyme morphogenesis)|go:"GO:0072520"(seminiferous tubule development)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1905305"(negative regulation of cardiac myofibril assembly)|go:"GO:2000617"(positive regulation of histone H3-K9 acetylation)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|mint:P97471|rcsb pdb:3QSV|reactome:R-MMU-1181150|reactome:R-MMU-1502540|reactome:R-MMU-201451|reactome:R-MMU-2173789|reactome:R-MMU-2173795|reactome:R-MMU-2173796|reactome:R-MMU-5689880|reactome:R-MMU-8941326|reactome:R-MMU-8941855|reactome:R-MMU-9617828|mint:MINT-7289514(identity)	-	comment:mint	-	figure legend:F6B|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-c2c12)|taxid:10090(Mouse C3H muscle myoblast)	-	2009/10/08	2014/10/16	rogid:P+szNlUos2Nnfev1xiY4J5ztVTQ10090	rogid:IJFXHvSWr9ahHMgHAekwlFtH57w10090	intact-crc:B215A909D40B442F|rigid:FDUDjy2V7/ExhYaUY6cuSMTDz04	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P0C605	uniprotkb:Q9ESZ8	intact:EBI-6991999|ensembl:ENSMUSP00000067576|intact:MINT-7289393|uniprotkb:Q9Z0Z0|uniprotkb:Q14DK6|intact:UNK-5561184	intact:EBI-6876774|ensembl:ENSMUSP00000049625|ensembl:ENSMUSP00000133566|uniprotkb:O54700|uniprotkb:O55030|uniprotkb:O55031|uniprotkb:Q8VHD1|uniprotkb:Q8VHD2|uniprotkb:Q8VHD3|uniprotkb:Q8VHD4|uniprotkb:Q9CSB5|uniprotkb:Q9D9K9	psi-mi:kgp1_mouse(display_long)|uniprotkb:Prkg1(gene name)|psi-mi:Prkg1(display_short)|uniprotkb:Prkgr1a(gene name synonym)|uniprotkb:Prkg1b(gene name synonym)|uniprotkb:Prkgr1b(gene name synonym)|uniprotkb:cGMP-dependent protein kinase I(gene name synonym)	psi-mi:gtf2i_mouse(display_long)|uniprotkb:Gtf2i(gene name)|psi-mi:Gtf2i(display_short)|uniprotkb:Bap135(gene name synonym)|uniprotkb:Diws1t(gene name synonym)|uniprotkb:Bruton tyrosine kinase-associated protein 135(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Schwappacher et al. (2009)	pubmed:19424179|imex:IM-13879|mint:MINT-7289369|doi:10.1038/emboj.2009.103	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-6992107|mint:MINT-7289511|imex:IM-13879-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006526831.1|ensembl:ENSMUSG00000052920(gene)|ensembl:ENSMUST00000065067(transcript)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0001764"(neuron migration)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004692"(cGMP-dependent protein kinase activity)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0010920"(negative regulation of inositol phosphate biosynthetic process)|go:"GO:0014050"(negative regulation of glutamate secretion)|go:"GO:0014912"(negative regulation of smooth muscle cell migration)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0019934"(cGMP-mediated signaling)|go:"GO:0030553"(cGMP binding)|go:"GO:0030900"(forebrain development)|go:"GO:0042311"(vasodilation)|go:"GO:0042753"(positive regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0045822"(negative regulation of heart contraction)|go:"GO:0045986"(negative regulation of smooth muscle contraction)|go:"GO:0048273"(mitogen-activated protein kinase p38 binding)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0061049"(cell growth involved in cardiac muscle cell development)|go:"GO:0090331"(negative regulation of platelet aggregation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902608"(positive regulation of large conductance calcium-activated potassium channel activity)|go:"GO:1904753"(negative regulation of vascular associated smooth muscle cell migration)|go:"GO:2000224"(regulation of testosterone biosynthetic process)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR002374(cGMP-dependent protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR018488|interpro:IPR018490|interpro:IPR031831|interpro:IPR035014|mint:P0C605|reactome:R-MMU-392517|reactome:R-MMU-418457|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|refseq:NP_001013855.1|refseq:NP_035290.1|dip:DIP-29981N|mint:MINT-7289516(identity)	refseq:XP_017176169.1|refseq:XP_017176170.1|ensembl:ENSMUSG00000060261(gene)|ensembl:ENSMUST00000059042(transcript)|ensembl:ENSMUST00000174155(transcript)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0100026"(positive regulation of DNA repair by transcription from RNA polymerase II promoter)|interpro:IPR004212(GTF2I-like repeat)|interpro:IPR016659(Transcription factor II-I)|interpro:IPR036647|mint:Q9ESZ8|rcsb pdb:1Q60|refseq:NP_001074215.1|refseq:NP_001074216.1|refseq:NP_001074217.1|refseq:NP_034495.2|mint:MINT-7289522(identity)	-	comment:mint	-	figure legend:F6B|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-c2c12)|taxid:10090(Mouse C3H muscle myoblast)	-	2009/10/08	2014/10/16	rogid:P+szNlUos2Nnfev1xiY4J5ztVTQ10090	rogid:OT63xMPsr6JrPGl2oNXnwQqe2do10090	intact-crc:B215A909D40B442F|rigid:FDUDjy2V7/ExhYaUY6cuSMTDz04	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P97471	uniprotkb:P70340	intact:EBI-5259270|uniprotkb:Q6GTP6|uniprotkb:Q9CW56|ensembl:ENSMUSP00000025393|ensembl:ENSMUSP00000110589	intact:EBI-6992047|ensembl:ENSMUSP00000071035|uniprotkb:Q6GT95|uniprotkb:P70442|uniprotkb:Q9CYK6|intact:MINT-99213	psi-mi:smad4_mouse(display_long)|uniprotkb:Smad4(gene name)|psi-mi:Smad4(display_short)|uniprotkb:Dpc4(gene name synonym)|uniprotkb:Madh4(gene name synonym)|uniprotkb:Deletion target in pancreatic carcinoma 4 homolog(gene name synonym)|uniprotkb:SMAD family member 4(gene name synonym)	psi-mi:smad1_mouse(display_long)|uniprotkb:Smad1(gene name)|psi-mi:Smad1(display_short)|uniprotkb:Madh1(gene name synonym)|uniprotkb:Madr1(gene name synonym)|uniprotkb:Mothers-against-DPP-related 1(gene name synonym)|uniprotkb:Dwarfin-A(gene name synonym)|uniprotkb:SMAD family member 1(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Schwappacher et al. (2009)	pubmed:19424179|imex:IM-13879|mint:MINT-7289369|doi:10.1038/emboj.2009.103	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-6992158|mint:MINT-7289542|imex:IM-13879-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032566.2|dip:DIP-29718N|ensembl:ENSMUSG00000024515(gene)|ensembl:ENSMUST00000025393(transcript)|ensembl:ENSMUST00000114939(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0001822"(kidney development)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003190"(atrioventricular valve formation)|go:"GO:0003198"(epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:0003220"(left ventricular cardiac muscle tissue morphogenesis)|go:"GO:0003251"(positive regulation of cell proliferation involved in heart valve morphogenesis)|go:"GO:0003279"(cardiac septum development)|go:"GO:0003360"(brainstem development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005518"(collagen binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0007369"(gastrulation)|go:"GO:0007411"(axon guidance)|go:"GO:0007492"(endoderm development)|go:"GO:0007498"(mesoderm development)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008584"(male gonad development)|go:"GO:0008585"(female gonad development)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0014033"(neural crest cell differentiation)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030154"(cell differentiation)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0031005"(filamin binding)|go:"GO:0032444"(activin responsive factor complex)|go:"GO:0032525"(somite rostral/caudal axis specification)|go:"GO:0032909"(regulation of transforming growth factor beta2 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033686"(positive regulation of luteinizing hormone secretion)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036302"(atrioventricular canal development)|go:"GO:0042060"(wound healing)|go:"GO:0042118"(endothelial cell activation)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043199"(sulfate binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0046881"(positive regulation of follicle-stimulating hormone secretion)|go:"GO:0048382"(mesendoderm development)|go:"GO:0048589"(developmental growth)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048729"(tissue morphogenesis)|go:"GO:0048733"(sebaceous gland development)|go:"GO:0048859"(formation of anatomical boundary)|go:"GO:0051098"(regulation of binding)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051797"(regulation of hair follicle development)|go:"GO:0060065"(uterus development)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0060956"(endocardial cell differentiation)|go:"GO:0061040"(female gonad morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0062009"(secondary palate development)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0071141"(SMAD protein complex)|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071559"(response to transforming growth factor beta)|go:"GO:0072133"(metanephric mesenchyme morphogenesis)|go:"GO:0072134"(nephrogenic mesenchyme morphogenesis)|go:"GO:0072520"(seminiferous tubule development)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1905305"(negative regulation of cardiac myofibril assembly)|go:"GO:2000617"(positive regulation of histone H3-K9 acetylation)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|mint:P97471|rcsb pdb:3QSV|reactome:R-MMU-1181150|reactome:R-MMU-1502540|reactome:R-MMU-201451|reactome:R-MMU-2173789|reactome:R-MMU-2173795|reactome:R-MMU-2173796|reactome:R-MMU-5689880|reactome:R-MMU-8941326|reactome:R-MMU-8941855|reactome:R-MMU-9617828|mint:MINT-7289544(identity)	refseq:XP_006530809.1|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0017151"(DEAD/H-box RNA helicase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030901"(midbrain development)|go:"GO:0006954"(inflammatory response)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0030902"(hindbrain development)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042493"|go:"GO:0042592"(homeostatic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0051216"(cartilage development)|go:"GO:0060038"(cardiac muscle cell proliferation)|go:"GO:0060348"(bone development)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0007276"(gamete generation)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0070410"(co-SMAD binding)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|mint:P70340|rcsb pdb:3KMP|reactome:R-MMU-201451|reactome:R-MMU-5689880|reactome:R-MMU-8941326|ensembl:ENSMUSG00000031681(gene)|ensembl:ENSMUST00000066091(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0002051"(osteoblast fate commitment)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006468"(protein phosphorylation)|refseq:NP_032565.2|mint:MINT-7289548(identity)	-	-	comment:mint|function:"Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD1 is a receptor-regulated SMAD (R-SMAD) (By similarity). May play a role in the initiation and maintenance of spermatogenesis"	figure legend:F6B|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-c2c12)|taxid:10090(Mouse C3H muscle myoblast)	-	2009/10/08	2014/10/16	rogid:IJFXHvSWr9ahHMgHAekwlFtH57w10090	rogid:D3Mhh31YZUsykSUfzewNuy8NyrY10090	intact-crc:60528B3FB0A7A2AF|rigid:FDUDjy2V7/ExhYaUY6cuSMTDz04	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P97471	uniprotkb:P0C605	intact:EBI-5259270|uniprotkb:Q6GTP6|uniprotkb:Q9CW56|ensembl:ENSMUSP00000025393|ensembl:ENSMUSP00000110589	intact:EBI-6991999|ensembl:ENSMUSP00000067576|intact:MINT-7289393|uniprotkb:Q9Z0Z0|uniprotkb:Q14DK6|intact:UNK-5561184	psi-mi:smad4_mouse(display_long)|uniprotkb:Smad4(gene name)|psi-mi:Smad4(display_short)|uniprotkb:Dpc4(gene name synonym)|uniprotkb:Madh4(gene name synonym)|uniprotkb:Deletion target in pancreatic carcinoma 4 homolog(gene name synonym)|uniprotkb:SMAD family member 4(gene name synonym)	psi-mi:kgp1_mouse(display_long)|uniprotkb:Prkg1(gene name)|psi-mi:Prkg1(display_short)|uniprotkb:Prkgr1a(gene name synonym)|uniprotkb:Prkg1b(gene name synonym)|uniprotkb:Prkgr1b(gene name synonym)|uniprotkb:cGMP-dependent protein kinase I(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Schwappacher et al. (2009)	pubmed:19424179|imex:IM-13879|mint:MINT-7289369|doi:10.1038/emboj.2009.103	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-6992158|mint:MINT-7289542|imex:IM-13879-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032566.2|dip:DIP-29718N|ensembl:ENSMUSG00000024515(gene)|ensembl:ENSMUST00000025393(transcript)|ensembl:ENSMUST00000114939(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0001822"(kidney development)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003190"(atrioventricular valve formation)|go:"GO:0003198"(epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:0003220"(left ventricular cardiac muscle tissue morphogenesis)|go:"GO:0003251"(positive regulation of cell proliferation involved in heart valve morphogenesis)|go:"GO:0003279"(cardiac septum development)|go:"GO:0003360"(brainstem development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005518"(collagen binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0007369"(gastrulation)|go:"GO:0007411"(axon guidance)|go:"GO:0007492"(endoderm development)|go:"GO:0007498"(mesoderm development)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008584"(male gonad development)|go:"GO:0008585"(female gonad development)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0014033"(neural crest cell differentiation)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030154"(cell differentiation)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0031005"(filamin binding)|go:"GO:0032444"(activin responsive factor complex)|go:"GO:0032525"(somite rostral/caudal axis specification)|go:"GO:0032909"(regulation of transforming growth factor beta2 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033686"(positive regulation of luteinizing hormone secretion)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036302"(atrioventricular canal development)|go:"GO:0042060"(wound healing)|go:"GO:0042118"(endothelial cell activation)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043199"(sulfate binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0046881"(positive regulation of follicle-stimulating hormone secretion)|go:"GO:0048382"(mesendoderm development)|go:"GO:0048589"(developmental growth)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048729"(tissue morphogenesis)|go:"GO:0048733"(sebaceous gland development)|go:"GO:0048859"(formation of anatomical boundary)|go:"GO:0051098"(regulation of binding)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051797"(regulation of hair follicle development)|go:"GO:0060065"(uterus development)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0060956"(endocardial cell differentiation)|go:"GO:0061040"(female gonad morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0062009"(secondary palate development)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0071141"(SMAD protein complex)|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071559"(response to transforming growth factor beta)|go:"GO:0072133"(metanephric mesenchyme morphogenesis)|go:"GO:0072134"(nephrogenic mesenchyme morphogenesis)|go:"GO:0072520"(seminiferous tubule development)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1905305"(negative regulation of cardiac myofibril assembly)|go:"GO:2000617"(positive regulation of histone H3-K9 acetylation)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|mint:P97471|rcsb pdb:3QSV|reactome:R-MMU-1181150|reactome:R-MMU-1502540|reactome:R-MMU-201451|reactome:R-MMU-2173789|reactome:R-MMU-2173795|reactome:R-MMU-2173796|reactome:R-MMU-5689880|reactome:R-MMU-8941326|reactome:R-MMU-8941855|reactome:R-MMU-9617828|mint:MINT-7289544(identity)	refseq:XP_006526831.1|ensembl:ENSMUSG00000052920(gene)|ensembl:ENSMUST00000065067(transcript)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0001764"(neuron migration)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004692"(cGMP-dependent protein kinase activity)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0010920"(negative regulation of inositol phosphate biosynthetic process)|go:"GO:0014050"(negative regulation of glutamate secretion)|go:"GO:0014912"(negative regulation of smooth muscle cell migration)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0019934"(cGMP-mediated signaling)|go:"GO:0030553"(cGMP binding)|go:"GO:0030900"(forebrain development)|go:"GO:0042311"(vasodilation)|go:"GO:0042753"(positive regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0045822"(negative regulation of heart contraction)|go:"GO:0045986"(negative regulation of smooth muscle contraction)|go:"GO:0048273"(mitogen-activated protein kinase p38 binding)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0061049"(cell growth involved in cardiac muscle cell development)|go:"GO:0090331"(negative regulation of platelet aggregation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902608"(positive regulation of large conductance calcium-activated potassium channel activity)|go:"GO:1904753"(negative regulation of vascular associated smooth muscle cell migration)|go:"GO:2000224"(regulation of testosterone biosynthetic process)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR002374(cGMP-dependent protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR018488|interpro:IPR018490|interpro:IPR031831|interpro:IPR035014|mint:P0C605|reactome:R-MMU-392517|reactome:R-MMU-418457|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|refseq:NP_001013855.1|refseq:NP_035290.1|dip:DIP-29981N|mint:MINT-7289546(identity)	-	-	comment:mint	figure legend:F6B|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-c2c12)|taxid:10090(Mouse C3H muscle myoblast)	-	2009/10/08	2014/10/16	rogid:IJFXHvSWr9ahHMgHAekwlFtH57w10090	rogid:P+szNlUos2Nnfev1xiY4J5ztVTQ10090	intact-crc:60528B3FB0A7A2AF|rigid:FDUDjy2V7/ExhYaUY6cuSMTDz04	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P97471	uniprotkb:Q9ESZ8	intact:EBI-5259270|uniprotkb:Q6GTP6|uniprotkb:Q9CW56|ensembl:ENSMUSP00000025393|ensembl:ENSMUSP00000110589	intact:EBI-6876774|ensembl:ENSMUSP00000049625|ensembl:ENSMUSP00000133566|uniprotkb:O54700|uniprotkb:O55030|uniprotkb:O55031|uniprotkb:Q8VHD1|uniprotkb:Q8VHD2|uniprotkb:Q8VHD3|uniprotkb:Q8VHD4|uniprotkb:Q9CSB5|uniprotkb:Q9D9K9	psi-mi:smad4_mouse(display_long)|uniprotkb:Smad4(gene name)|psi-mi:Smad4(display_short)|uniprotkb:Dpc4(gene name synonym)|uniprotkb:Madh4(gene name synonym)|uniprotkb:Deletion target in pancreatic carcinoma 4 homolog(gene name synonym)|uniprotkb:SMAD family member 4(gene name synonym)	psi-mi:gtf2i_mouse(display_long)|uniprotkb:Gtf2i(gene name)|psi-mi:Gtf2i(display_short)|uniprotkb:Bap135(gene name synonym)|uniprotkb:Diws1t(gene name synonym)|uniprotkb:Bruton tyrosine kinase-associated protein 135(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Schwappacher et al. (2009)	pubmed:19424179|imex:IM-13879|mint:MINT-7289369|doi:10.1038/emboj.2009.103	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-6992158|mint:MINT-7289542|imex:IM-13879-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032566.2|dip:DIP-29718N|ensembl:ENSMUSG00000024515(gene)|ensembl:ENSMUST00000025393(transcript)|ensembl:ENSMUST00000114939(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0001822"(kidney development)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003190"(atrioventricular valve formation)|go:"GO:0003198"(epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:0003220"(left ventricular cardiac muscle tissue morphogenesis)|go:"GO:0003251"(positive regulation of cell proliferation involved in heart valve morphogenesis)|go:"GO:0003279"(cardiac septum development)|go:"GO:0003360"(brainstem development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005518"(collagen binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0007369"(gastrulation)|go:"GO:0007411"(axon guidance)|go:"GO:0007492"(endoderm development)|go:"GO:0007498"(mesoderm development)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008584"(male gonad development)|go:"GO:0008585"(female gonad development)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0014033"(neural crest cell differentiation)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030154"(cell differentiation)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0031005"(filamin binding)|go:"GO:0032444"(activin responsive factor complex)|go:"GO:0032525"(somite rostral/caudal axis specification)|go:"GO:0032909"(regulation of transforming growth factor beta2 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033686"(positive regulation of luteinizing hormone secretion)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036302"(atrioventricular canal development)|go:"GO:0042060"(wound healing)|go:"GO:0042118"(endothelial cell activation)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043199"(sulfate binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0046881"(positive regulation of follicle-stimulating hormone secretion)|go:"GO:0048382"(mesendoderm development)|go:"GO:0048589"(developmental growth)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048729"(tissue morphogenesis)|go:"GO:0048733"(sebaceous gland development)|go:"GO:0048859"(formation of anatomical boundary)|go:"GO:0051098"(regulation of binding)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051797"(regulation of hair follicle development)|go:"GO:0060065"(uterus development)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0060956"(endocardial cell differentiation)|go:"GO:0061040"(female gonad morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0062009"(secondary palate development)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0071141"(SMAD protein complex)|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071559"(response to transforming growth factor beta)|go:"GO:0072133"(metanephric mesenchyme morphogenesis)|go:"GO:0072134"(nephrogenic mesenchyme morphogenesis)|go:"GO:0072520"(seminiferous tubule development)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1905305"(negative regulation of cardiac myofibril assembly)|go:"GO:2000617"(positive regulation of histone H3-K9 acetylation)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|mint:P97471|rcsb pdb:3QSV|reactome:R-MMU-1181150|reactome:R-MMU-1502540|reactome:R-MMU-201451|reactome:R-MMU-2173789|reactome:R-MMU-2173795|reactome:R-MMU-2173796|reactome:R-MMU-5689880|reactome:R-MMU-8941326|reactome:R-MMU-8941855|reactome:R-MMU-9617828|mint:MINT-7289544(identity)	refseq:XP_017176169.1|refseq:XP_017176170.1|ensembl:ENSMUSG00000060261(gene)|ensembl:ENSMUST00000059042(transcript)|ensembl:ENSMUST00000174155(transcript)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0100026"(positive regulation of DNA repair by transcription from RNA polymerase II promoter)|interpro:IPR004212(GTF2I-like repeat)|interpro:IPR016659(Transcription factor II-I)|interpro:IPR036647|mint:Q9ESZ8|rcsb pdb:1Q60|refseq:NP_001074215.1|refseq:NP_001074216.1|refseq:NP_001074217.1|refseq:NP_034495.2|mint:MINT-7289550(identity)	-	-	-	figure legend:F6B|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-c2c12)|taxid:10090(Mouse C3H muscle myoblast)	-	2009/10/08	2014/10/16	rogid:IJFXHvSWr9ahHMgHAekwlFtH57w10090	rogid:OT63xMPsr6JrPGl2oNXnwQqe2do10090	intact-crc:60528B3FB0A7A2AF|rigid:FDUDjy2V7/ExhYaUY6cuSMTDz04	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P70340	uniprotkb:P0C605	intact:EBI-6992047|ensembl:ENSMUSP00000071035|uniprotkb:Q6GT95|uniprotkb:P70442|uniprotkb:Q9CYK6|intact:MINT-99213	intact:EBI-6991999|ensembl:ENSMUSP00000067576|intact:MINT-7289393|uniprotkb:Q9Z0Z0|uniprotkb:Q14DK6|intact:UNK-5561184	psi-mi:smad1_mouse(display_long)|uniprotkb:Smad1(gene name)|psi-mi:Smad1(display_short)|uniprotkb:Madh1(gene name synonym)|uniprotkb:Madr1(gene name synonym)|uniprotkb:Mothers-against-DPP-related 1(gene name synonym)|uniprotkb:Dwarfin-A(gene name synonym)|uniprotkb:SMAD family member 1(gene name synonym)	psi-mi:kgp1_mouse(display_long)|uniprotkb:Prkg1(gene name)|psi-mi:Prkg1(display_short)|uniprotkb:Prkgr1a(gene name synonym)|uniprotkb:Prkg1b(gene name synonym)|uniprotkb:Prkgr1b(gene name synonym)|uniprotkb:cGMP-dependent protein kinase I(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Schwappacher et al. (2009)	pubmed:19424179|imex:IM-13879|mint:MINT-7289369|doi:10.1038/emboj.2009.103	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-6992140|mint:MINT-7289529|imex:IM-13879-12	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006530809.1|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0017151"(DEAD/H-box RNA helicase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030901"(midbrain development)|go:"GO:0006954"(inflammatory response)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0030902"(hindbrain development)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042493"|go:"GO:0042592"(homeostatic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0051216"(cartilage development)|go:"GO:0060038"(cardiac muscle cell proliferation)|go:"GO:0060348"(bone development)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0007276"(gamete generation)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0070410"(co-SMAD binding)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|mint:P70340|rcsb pdb:3KMP|reactome:R-MMU-201451|reactome:R-MMU-5689880|reactome:R-MMU-8941326|ensembl:ENSMUSG00000031681(gene)|ensembl:ENSMUST00000066091(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0002051"(osteoblast fate commitment)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006468"(protein phosphorylation)|refseq:NP_032565.2|mint:MINT-7289533(identity)	refseq:XP_006526831.1|ensembl:ENSMUSG00000052920(gene)|ensembl:ENSMUST00000065067(transcript)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0001764"(neuron migration)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004692"(cGMP-dependent protein kinase activity)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0010920"(negative regulation of inositol phosphate biosynthetic process)|go:"GO:0014050"(negative regulation of glutamate secretion)|go:"GO:0014912"(negative regulation of smooth muscle cell migration)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0019934"(cGMP-mediated signaling)|go:"GO:0030553"(cGMP binding)|go:"GO:0030900"(forebrain development)|go:"GO:0042311"(vasodilation)|go:"GO:0042753"(positive regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0045822"(negative regulation of heart contraction)|go:"GO:0045986"(negative regulation of smooth muscle contraction)|go:"GO:0048273"(mitogen-activated protein kinase p38 binding)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0061049"(cell growth involved in cardiac muscle cell development)|go:"GO:0090331"(negative regulation of platelet aggregation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902608"(positive regulation of large conductance calcium-activated potassium channel activity)|go:"GO:1904753"(negative regulation of vascular associated smooth muscle cell migration)|go:"GO:2000224"(regulation of testosterone biosynthetic process)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR002374(cGMP-dependent protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR018488|interpro:IPR018490|interpro:IPR031831|interpro:IPR035014|mint:P0C605|reactome:R-MMU-392517|reactome:R-MMU-418457|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|refseq:NP_001013855.1|refseq:NP_035290.1|dip:DIP-29981N|mint:MINT-7289535(identity)	-	comment:mint|function:"Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD1 is a receptor-regulated SMAD (R-SMAD) (By similarity). May play a role in the initiation and maintenance of spermatogenesis"	comment:mint	figure legend:F6B|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-c2c12)|taxid:10090(Mouse C3H muscle myoblast)	-	2009/10/08	2014/10/16	rogid:D3Mhh31YZUsykSUfzewNuy8NyrY10090	rogid:P+szNlUos2Nnfev1xiY4J5ztVTQ10090	intact-crc:8254407107C23ABD|rigid:FDUDjy2V7/ExhYaUY6cuSMTDz04	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P70340	uniprotkb:Q9ESZ8	intact:EBI-6992047|ensembl:ENSMUSP00000071035|uniprotkb:Q6GT95|uniprotkb:P70442|uniprotkb:Q9CYK6|intact:MINT-99213	intact:EBI-6876774|ensembl:ENSMUSP00000049625|ensembl:ENSMUSP00000133566|uniprotkb:O54700|uniprotkb:O55030|uniprotkb:O55031|uniprotkb:Q8VHD1|uniprotkb:Q8VHD2|uniprotkb:Q8VHD3|uniprotkb:Q8VHD4|uniprotkb:Q9CSB5|uniprotkb:Q9D9K9	psi-mi:smad1_mouse(display_long)|uniprotkb:Smad1(gene name)|psi-mi:Smad1(display_short)|uniprotkb:Madh1(gene name synonym)|uniprotkb:Madr1(gene name synonym)|uniprotkb:Mothers-against-DPP-related 1(gene name synonym)|uniprotkb:Dwarfin-A(gene name synonym)|uniprotkb:SMAD family member 1(gene name synonym)	psi-mi:gtf2i_mouse(display_long)|uniprotkb:Gtf2i(gene name)|psi-mi:Gtf2i(display_short)|uniprotkb:Bap135(gene name synonym)|uniprotkb:Diws1t(gene name synonym)|uniprotkb:Bruton tyrosine kinase-associated protein 135(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Schwappacher et al. (2009)	pubmed:19424179|imex:IM-13879|mint:MINT-7289369|doi:10.1038/emboj.2009.103	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-6992140|mint:MINT-7289529|imex:IM-13879-12	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006530809.1|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0017151"(DEAD/H-box RNA helicase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030901"(midbrain development)|go:"GO:0006954"(inflammatory response)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0030902"(hindbrain development)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042493"|go:"GO:0042592"(homeostatic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0051216"(cartilage development)|go:"GO:0060038"(cardiac muscle cell proliferation)|go:"GO:0060348"(bone development)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0007276"(gamete generation)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0070410"(co-SMAD binding)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|mint:P70340|rcsb pdb:3KMP|reactome:R-MMU-201451|reactome:R-MMU-5689880|reactome:R-MMU-8941326|ensembl:ENSMUSG00000031681(gene)|ensembl:ENSMUST00000066091(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0002051"(osteoblast fate commitment)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006468"(protein phosphorylation)|refseq:NP_032565.2|mint:MINT-7289533(identity)	refseq:XP_017176169.1|refseq:XP_017176170.1|ensembl:ENSMUSG00000060261(gene)|ensembl:ENSMUST00000059042(transcript)|ensembl:ENSMUST00000174155(transcript)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0100026"(positive regulation of DNA repair by transcription from RNA polymerase II promoter)|interpro:IPR004212(GTF2I-like repeat)|interpro:IPR016659(Transcription factor II-I)|interpro:IPR036647|mint:Q9ESZ8|rcsb pdb:1Q60|refseq:NP_001074215.1|refseq:NP_001074216.1|refseq:NP_001074217.1|refseq:NP_034495.2|mint:MINT-7289531(identity)	-	comment:mint|function:"Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD1 is a receptor-regulated SMAD (R-SMAD) (By similarity). May play a role in the initiation and maintenance of spermatogenesis"	-	figure legend:F6B|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-c2c12)|taxid:10090(Mouse C3H muscle myoblast)	-	2009/10/08	2014/10/16	rogid:D3Mhh31YZUsykSUfzewNuy8NyrY10090	rogid:OT63xMPsr6JrPGl2oNXnwQqe2do10090	intact-crc:8254407107C23ABD|rigid:FDUDjy2V7/ExhYaUY6cuSMTDz04	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P70340	uniprotkb:P97471	intact:EBI-6992047|ensembl:ENSMUSP00000071035|uniprotkb:Q6GT95|uniprotkb:P70442|uniprotkb:Q9CYK6|intact:MINT-99213	intact:EBI-5259270|uniprotkb:Q6GTP6|uniprotkb:Q9CW56|ensembl:ENSMUSP00000025393|ensembl:ENSMUSP00000110589	psi-mi:smad1_mouse(display_long)|uniprotkb:Smad1(gene name)|psi-mi:Smad1(display_short)|uniprotkb:Madh1(gene name synonym)|uniprotkb:Madr1(gene name synonym)|uniprotkb:Mothers-against-DPP-related 1(gene name synonym)|uniprotkb:Dwarfin-A(gene name synonym)|uniprotkb:SMAD family member 1(gene name synonym)	psi-mi:smad4_mouse(display_long)|uniprotkb:Smad4(gene name)|psi-mi:Smad4(display_short)|uniprotkb:Dpc4(gene name synonym)|uniprotkb:Madh4(gene name synonym)|uniprotkb:Deletion target in pancreatic carcinoma 4 homolog(gene name synonym)|uniprotkb:SMAD family member 4(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Schwappacher et al. (2009)	pubmed:19424179|imex:IM-13879|mint:MINT-7289369|doi:10.1038/emboj.2009.103	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-6992140|mint:MINT-7289529|imex:IM-13879-12	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006530809.1|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0017151"(DEAD/H-box RNA helicase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030901"(midbrain development)|go:"GO:0006954"(inflammatory response)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0030902"(hindbrain development)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042493"|go:"GO:0042592"(homeostatic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0051216"(cartilage development)|go:"GO:0060038"(cardiac muscle cell proliferation)|go:"GO:0060348"(bone development)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0007276"(gamete generation)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0070410"(co-SMAD binding)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|mint:P70340|rcsb pdb:3KMP|reactome:R-MMU-201451|reactome:R-MMU-5689880|reactome:R-MMU-8941326|ensembl:ENSMUSG00000031681(gene)|ensembl:ENSMUST00000066091(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0002051"(osteoblast fate commitment)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006468"(protein phosphorylation)|refseq:NP_032565.2|mint:MINT-7289533(identity)	refseq:NP_032566.2|dip:DIP-29718N|ensembl:ENSMUSG00000024515(gene)|ensembl:ENSMUST00000025393(transcript)|ensembl:ENSMUST00000114939(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0001822"(kidney development)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003190"(atrioventricular valve formation)|go:"GO:0003198"(epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:0003220"(left ventricular cardiac muscle tissue morphogenesis)|go:"GO:0003251"(positive regulation of cell proliferation involved in heart valve morphogenesis)|go:"GO:0003279"(cardiac septum development)|go:"GO:0003360"(brainstem development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005518"(collagen binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0007369"(gastrulation)|go:"GO:0007411"(axon guidance)|go:"GO:0007492"(endoderm development)|go:"GO:0007498"(mesoderm development)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008584"(male gonad development)|go:"GO:0008585"(female gonad development)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0014033"(neural crest cell differentiation)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030154"(cell differentiation)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0031005"(filamin binding)|go:"GO:0032444"(activin responsive factor complex)|go:"GO:0032525"(somite rostral/caudal axis specification)|go:"GO:0032909"(regulation of transforming growth factor beta2 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033686"(positive regulation of luteinizing hormone secretion)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036302"(atrioventricular canal development)|go:"GO:0042060"(wound healing)|go:"GO:0042118"(endothelial cell activation)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043199"(sulfate binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0046881"(positive regulation of follicle-stimulating hormone secretion)|go:"GO:0048382"(mesendoderm development)|go:"GO:0048589"(developmental growth)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048729"(tissue morphogenesis)|go:"GO:0048733"(sebaceous gland development)|go:"GO:0048859"(formation of anatomical boundary)|go:"GO:0051098"(regulation of binding)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051797"(regulation of hair follicle development)|go:"GO:0060065"(uterus development)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0060956"(endocardial cell differentiation)|go:"GO:0061040"(female gonad morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0062009"(secondary palate development)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0071141"(SMAD protein complex)|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071559"(response to transforming growth factor beta)|go:"GO:0072133"(metanephric mesenchyme morphogenesis)|go:"GO:0072134"(nephrogenic mesenchyme morphogenesis)|go:"GO:0072520"(seminiferous tubule development)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1905305"(negative regulation of cardiac myofibril assembly)|go:"GO:2000617"(positive regulation of histone H3-K9 acetylation)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|mint:P97471|rcsb pdb:3QSV|reactome:R-MMU-1181150|reactome:R-MMU-1502540|reactome:R-MMU-201451|reactome:R-MMU-2173789|reactome:R-MMU-2173795|reactome:R-MMU-2173796|reactome:R-MMU-5689880|reactome:R-MMU-8941326|reactome:R-MMU-8941855|reactome:R-MMU-9617828|mint:MINT-7289537(identity)	-	comment:mint|function:"Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD1 is a receptor-regulated SMAD (R-SMAD) (By similarity). May play a role in the initiation and maintenance of spermatogenesis"	-	figure legend:F6B|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-c2c12)|taxid:10090(Mouse C3H muscle myoblast)	-	2009/10/08	2014/10/16	rogid:D3Mhh31YZUsykSUfzewNuy8NyrY10090	rogid:IJFXHvSWr9ahHMgHAekwlFtH57w10090	intact-crc:8254407107C23ABD|rigid:FDUDjy2V7/ExhYaUY6cuSMTDz04	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q13976	uniprotkb:Q13873	intact:EBI-3952014|uniprotkb:Q6P5T7|uniprotkb:E2PU10|uniprotkb:P14619|uniprotkb:Q5JSJ6|ensembl:ENSP00000384200|uniprotkb:A5YM56|uniprotkb:B3KSF3|uniprotkb:Q5JP05	intact:EBI-527196|uniprotkb:Q16569|uniprotkb:Q13161|uniprotkb:Q4ZG08|uniprotkb:Q53SA5|uniprotkb:Q585T8|ensembl:ENSP00000363708	psi-mi:kgp1_human(display_long)|uniprotkb:PRKG1(gene name)|psi-mi:PRKG1(display_short)|uniprotkb:PRKG1B(gene name synonym)|uniprotkb:PRKGR1A(gene name synonym)|uniprotkb:PRKGR1B(gene name synonym)|uniprotkb:cGMP-dependent protein kinase I(gene name synonym)	psi-mi:bmpr2_human(display_long)|uniprotkb:Bone morphogenetic protein receptor type II(gene name synonym)|uniprotkb:PPH1(gene name synonym)|uniprotkb:BMPR2(gene name)|psi-mi:BMPR2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Schwappacher et al. (2009)	pubmed:19424179|imex:IM-13879|mint:MINT-7289369|doi:10.1038/emboj.2009.103	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-6992232|mint:MINT-7289555|imex:IM-13879-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR018488|interpro:IPR018490|interpro:IPR031831|interpro:IPR035014|mint:Q13976|rcsb pdb:1ZXA|rcsb pdb:3NMD|rcsb pdb:3OCP|rcsb pdb:3OD0|rcsb pdb:3OGJ|rcsb pdb:4KU7|rcsb pdb:4KU8|rcsb pdb:4QX5|rcsb pdb:4QXK|rcsb pdb:4R4L|rcsb pdb:4R4M|rcsb pdb:4Z07|rcsb pdb:5J48|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:5JAX|rcsb pdb:5JD7|rcsb pdb:5L0N|rcsb pdb:6BDL|rcsb pdb:6BG2|rcsb pdb:6C0T|reactome:R-HSA-392517|reactome:R-HSA-4086398|reactome:R-HSA-418457|refseq:NP_001091982.1|refseq:NP_006249.1|ensembl:ENST00000401604(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004692"(cGMP-dependent protein kinase activity)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0016358"(dendrite development)|go:"GO:0019934"(cGMP-mediated signaling)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030553"(cGMP binding)|go:"GO:0030900"(forebrain development)|go:"GO:0042802"(identical protein binding)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0090331"(negative regulation of platelet aggregation)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904753"(negative regulation of vascular associated smooth muscle cell migration)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR002374(cGMP-dependent protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR014710(RmlC-like jelly roll fold)|ensembl:ENSG00000185532(gene)|dip:DIP-41118N|dip:DIP-46288N|mint:MINT-7289557(identity)	dip:DIP-5794N|refseq:NP_001195.2|ensembl:ENSG00000204217(gene)|ensembl:ENST00000374580(transcript)|go:"GO:0001568"(blood vessel development)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001893"(maternal placenta development)|go:"GO:0001935"(endothelial cell proliferation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001946"(lymphangiogenesis)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002063"(chondrocyte development)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003176"(aortic valve development)|go:"GO:0003177"(pulmonary valve development)|go:"GO:0003183"(mitral valve morphogenesis)|go:"GO:0003186"(tricuspid valve morphogenesis)|go:"GO:0003197"(endocardial cushion development)|go:"GO:0003252"(negative regulation of cell proliferation involved in heart valve morphogenesis)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005024"(transforming growth factor beta-activated receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005912"(adherens junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007178"(transmembrane receptor protein serine/threonine kinase signaling pathway)|go:"GO:0007420"(brain development)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0014916"(regulation of lung blood pressure)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016362"(activin receptor activity, type II)|go:"GO:0019211"(phosphatase activator activity)|go:"GO:0019838"(growth factor binding)|go:"GO:0030166"(proteoglycan biosynthetic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0030546"(signaling receptor activator activity)|go:"GO:0036122"(BMP binding)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043235"(receptor complex)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0044214"(spanning component of plasma membrane)|go:"GO:0045296"(cadherin binding)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045778"(positive regulation of ossification)|go:"GO:0045906"(negative regulation of vasoconstriction)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048286"(lung alveolus development)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0048842"(positive regulation of axon extension involved in axon guidance)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0060173"(limb development)|go:"GO:0060350"(endochondral bone morphogenesis)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060413"(atrial septum morphogenesis)|go:"GO:0060836"(lymphatic endothelial cell differentiation)|go:"GO:0060840"(artery development)|go:"GO:0060841"(venous blood vessel development)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0061298"(retina vasculature development in camera-type eye)|go:"GO:0061626"(pharyngeal arch artery morphogenesis)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0014069"(postsynaptic density)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0098821"(BMP receptor activity)|go:"GO:0140537"(transcription regulator activator activity)|go:"GO:1902731"(negative regulation of chondrocyte proliferation)|go:"GO:1905314"(semi-lunar valve development)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000279"(negative regulation of DNA biosynthetic process)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015770(Bone morphogenic protein type II receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q13873|rcsb pdb:2HLQ|rcsb pdb:3G2F|reactome:R-HSA-201451|go:"GO:0071773"(cellular response to BMP stimulus)|mint:MINT-7289558(identity)	-	caution:This sequence has been withdrawn from Uniprot.|crc64:51389502A5E5FBD2	-	figure legend:F1B|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2009/10/08	2014/10/16	rogid:FFagskyghjyYPihsoL8JaO0RXgY9606	rogid:ZnEZsCvOyBegC07WvkGwXMz6jAw9606	intact-crc:3B8135D63EA33825|rigid:dtQ2OTTWv+8iUzk63kV6BTqgjBU	false	-	ha tag:?-?(MINT-7289560)	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q13976	uniprotkb:Q13485	intact:EBI-3952014|uniprotkb:Q6P5T7|uniprotkb:E2PU10|uniprotkb:P14619|uniprotkb:Q5JSJ6|ensembl:ENSP00000384200|uniprotkb:A5YM56|uniprotkb:B3KSF3|uniprotkb:Q5JP05	intact:EBI-347263|uniprotkb:A8K405|ensembl:ENSP00000341551|ensembl:ENSP00000381452	psi-mi:kgp1_human(display_long)|uniprotkb:PRKG1(gene name)|psi-mi:PRKG1(display_short)|uniprotkb:PRKG1B(gene name synonym)|uniprotkb:PRKGR1A(gene name synonym)|uniprotkb:PRKGR1B(gene name synonym)|uniprotkb:cGMP-dependent protein kinase I(gene name synonym)	psi-mi:smad4_human(display_long)|uniprotkb:SMAD4(gene name)|psi-mi:SMAD4(display_short)|uniprotkb:DPC4(gene name synonym)|uniprotkb:MADH4(gene name synonym)|uniprotkb:SMAD family member 4(gene name synonym)|uniprotkb:Deletion target in pancreatic carcinoma 4(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Schwappacher et al. (2009)	pubmed:19424179|imex:IM-13879|mint:MINT-7289369|doi:10.1038/emboj.2009.103	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-6992284|mint:MINT-7289576|imex:IM-13879-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR018488|interpro:IPR018490|interpro:IPR031831|interpro:IPR035014|mint:Q13976|rcsb pdb:1ZXA|rcsb pdb:3NMD|rcsb pdb:3OCP|rcsb pdb:3OD0|rcsb pdb:3OGJ|rcsb pdb:4KU7|rcsb pdb:4KU8|rcsb pdb:4QX5|rcsb pdb:4QXK|rcsb pdb:4R4L|rcsb pdb:4R4M|rcsb pdb:4Z07|rcsb pdb:5J48|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:5JAX|rcsb pdb:5JD7|rcsb pdb:5L0N|rcsb pdb:6BDL|rcsb pdb:6BG2|rcsb pdb:6C0T|reactome:R-HSA-392517|reactome:R-HSA-4086398|reactome:R-HSA-418457|refseq:NP_001091982.1|refseq:NP_006249.1|ensembl:ENST00000401604(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004692"(cGMP-dependent protein kinase activity)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0016358"(dendrite development)|go:"GO:0019934"(cGMP-mediated signaling)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030553"(cGMP binding)|go:"GO:0030900"(forebrain development)|go:"GO:0042802"(identical protein binding)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0090331"(negative regulation of platelet aggregation)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904753"(negative regulation of vascular associated smooth muscle cell migration)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR002374(cGMP-dependent protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR014710(RmlC-like jelly roll fold)|ensembl:ENSG00000185532(gene)|dip:DIP-41118N|dip:DIP-46288N|mint:MINT-7289578(identity)	ensembl:ENSG00000141646(gene)|refseq:NP_005350.1|ensembl:ENST00000398417(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0003148"(outflow tract septum morphogenesis)|ensembl:ENST00000342988(transcript)|go:"GO:0003190"(atrioventricular valve formation)|go:"GO:0003198"(epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:0003220"(left ventricular cardiac muscle tissue morphogenesis)|go:"GO:0003251"(positive regulation of cell proliferation involved in heart valve morphogenesis)|go:"GO:0003360"(brainstem development)|go:"GO:0003682"(chromatin binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0007411"(axon guidance)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0014033"(neural crest cell differentiation)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030154"(cell differentiation)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0032444"(activin responsive factor complex)|go:"GO:0032525"(somite rostral/caudal axis specification)|go:"GO:0032909"(regulation of transforming growth factor beta2 production)|go:"GO:0033686"(positive regulation of luteinizing hormone secretion)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036302"(atrioventricular canal development)|go:"GO:0042118"(endothelial cell activation)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043199"(sulfate binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0046881"(positive regulation of follicle-stimulating hormone secretion)|go:"GO:0048382"(mesendoderm development)|go:"GO:0048589"(developmental growth)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048733"(sebaceous gland development)|go:"GO:0048859"(formation of anatomical boundary)|go:"GO:0051098"(regulation of binding)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051797"(regulation of hair follicle development)|go:"GO:0060065"(uterus development)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0060956"(endocardial cell differentiation)|go:"GO:0061040"(female gonad morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0062009"(secondary palate development)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0071141"(SMAD protein complex)|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0071559"(response to transforming growth factor beta)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0072133"(metanephric mesenchyme morphogenesis)|go:"GO:0072134"(nephrogenic mesenchyme morphogenesis)|go:"GO:0072520"(seminiferous tubule development)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1905305"(negative regulation of cardiac myofibril assembly)|go:"GO:0042803"(protein homodimerization activity)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|go:"GO:2000617"(positive regulation of histone H3-K9 acetylation)|mint:Q13485|rcsb pdb:1DD1|rcsb pdb:1G88|rcsb pdb:1MR1|rcsb pdb:1U7F|rcsb pdb:1U7V|rcsb pdb:1YGS|rcsb pdb:5C4V|rcsb pdb:5MEY|rcsb pdb:5MEZ|rcsb pdb:5MF0|rcsb pdb:5UWU|reactome:R-HSA-1181150|reactome:R-HSA-1502540|reactome:R-HSA-201451|reactome:R-HSA-2173789|reactome:R-HSA-2173795|reactome:R-HSA-2173796|reactome:R-HSA-3311021|reactome:R-HSA-3315487|reactome:R-HSA-452723|reactome:R-HSA-5689880|reactome:R-HSA-8941326|reactome:R-HSA-8941855|reactome:R-HSA-8952158|reactome:R-HSA-9615017|reactome:R-HSA-9617828|dip:DIP-31512N|mint:MINT-7289580(identity)	-	caution:This sequence has been withdrawn from Uniprot.|crc64:51389502A5E5FBD2	-	figure legend:F4B|comment:homomint|comment:mint|comment:Interaction increase when BMP-2 is also over-expressed.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2009/10/08	2014/10/16	rogid:FFagskyghjyYPihsoL8JaO0RXgY9606	rogid:mPu190hmySGV54KAtldys/IHuo89606	intact-crc:777E8ACD5D95D849|rigid:LyjDs0Dd6RAkZRXqDwJPQtnrmL8	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P0C605	uniprotkb:O35607	intact:EBI-6991999|ensembl:ENSMUSP00000067576|intact:MINT-7289393|uniprotkb:Q9Z0Z0|uniprotkb:Q14DK6|intact:UNK-5561184	intact:EBI-527224|ensembl:ENSMUSP00000084701	psi-mi:kgp1_mouse(display_long)|uniprotkb:Prkg1(gene name)|psi-mi:Prkg1(display_short)|uniprotkb:Prkgr1a(gene name synonym)|uniprotkb:Prkg1b(gene name synonym)|uniprotkb:Prkgr1b(gene name synonym)|uniprotkb:cGMP-dependent protein kinase I(gene name synonym)	psi-mi:bmpr2_mouse(display_long)|uniprotkb:Bone morphogenetic protein receptor type II(gene name synonym)|uniprotkb:BRK-3(gene name synonym)|uniprotkb:Bmpr2(gene name)|psi-mi:Bmpr2(display_short)	psi-mi:"MI:0096"(pull down)	Schwappacher et al. (2009)	pubmed:19424179|imex:IM-13879|mint:MINT-7289369|doi:10.1038/emboj.2009.103	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-6992306|mint:MINT-7289436|imex:IM-13879-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006526831.1|ensembl:ENSMUSG00000052920(gene)|ensembl:ENSMUST00000065067(transcript)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0001764"(neuron migration)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004692"(cGMP-dependent protein kinase activity)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0010920"(negative regulation of inositol phosphate biosynthetic process)|go:"GO:0014050"(negative regulation of glutamate secretion)|go:"GO:0014912"(negative regulation of smooth muscle cell migration)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0019934"(cGMP-mediated signaling)|go:"GO:0030553"(cGMP binding)|go:"GO:0030900"(forebrain development)|go:"GO:0042311"(vasodilation)|go:"GO:0042753"(positive regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0045822"(negative regulation of heart contraction)|go:"GO:0045986"(negative regulation of smooth muscle contraction)|go:"GO:0048273"(mitogen-activated protein kinase p38 binding)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0061049"(cell growth involved in cardiac muscle cell development)|go:"GO:0090331"(negative regulation of platelet aggregation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902608"(positive regulation of large conductance calcium-activated potassium channel activity)|go:"GO:1904753"(negative regulation of vascular associated smooth muscle cell migration)|go:"GO:2000224"(regulation of testosterone biosynthetic process)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR002374(cGMP-dependent protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR018488|interpro:IPR018490|interpro:IPR031831|interpro:IPR035014|mint:P0C605|reactome:R-MMU-392517|reactome:R-MMU-418457|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|refseq:NP_001013855.1|refseq:NP_035290.1|dip:DIP-29981N|mint:MINT-7289438(identity)	ensembl:ENSMUSG00000067336(gene)|ensembl:ENSMUST00000087435(transcript)|go:"GO:0001568"(blood vessel development)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001893"(maternal placenta development)|go:"GO:0001935"(endothelial cell proliferation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001946"(lymphangiogenesis)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002063"(chondrocyte development)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003176"(aortic valve development)|go:"GO:0003177"(pulmonary valve development)|go:"GO:0003183"(mitral valve morphogenesis)|go:"GO:0003186"(tricuspid valve morphogenesis)|go:"GO:0003197"(endocardial cushion development)|go:"GO:0003252"(negative regulation of cell proliferation involved in heart valve morphogenesis)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005024"(transforming growth factor beta-activated receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005912"(adherens junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007178"(transmembrane receptor protein serine/threonine kinase signaling pathway)|go:"GO:0007420"(brain development)|go:"GO:0009267"(cellular response to starvation)|refseq:NP_031587.1|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014916"(regulation of lung blood pressure)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019211"(phosphatase activator activity)|go:"GO:0019838"(growth factor binding)|go:"GO:0030166"(proteoglycan biosynthetic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0030546"(signaling receptor activator activity)|go:"GO:0036122"(BMP binding)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043235"(receptor complex)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045296"(cadherin binding)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045778"(positive regulation of ossification)|go:"GO:0045906"(negative regulation of vasoconstriction)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048286"(lung alveolus development)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0048842"(positive regulation of axon extension involved in axon guidance)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0060173"(limb development)|go:"GO:0060350"(endochondral bone morphogenesis)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060413"(atrial septum morphogenesis)|go:"GO:0060836"(lymphatic endothelial cell differentiation)|go:"GO:0060840"(artery development)|go:"GO:0060841"(venous blood vessel development)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0061298"(retina vasculature development in camera-type eye)|go:"GO:0061626"(pharyngeal arch artery morphogenesis)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0098821"(BMP receptor activity)|go:"GO:0140537"(transcription regulator activator activity)|go:"GO:1902731"(negative regulation of chondrocyte proliferation)|go:"GO:1905314"(semi-lunar valve development)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000279"(negative regulation of DNA biosynthetic process)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000333(Activin type II receptor)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015770(Bone morphogenic protein type II receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:O35607|reactome:R-MMU-201451|mint:MINT-7289440(identity)	-	comment:mint	-	figure legend:F1C|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/10/08	2014/10/16	rogid:P+szNlUos2Nnfev1xiY4J5ztVTQ10090	rogid:4Dbgj6TEhtrX/9jydmufYNfEh1M10090	intact-crc:44D4B2D0317E0803|rigid:XpLnjBUjFZc+5bempwU09bp4378	false	-	glutathione s tranferase tag:?-?(MINT-7289444)	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P0C605	uniprotkb:O35607	intact:EBI-6991999|ensembl:ENSMUSP00000067576|intact:MINT-7289393|uniprotkb:Q9Z0Z0|uniprotkb:Q14DK6|intact:UNK-5561184	intact:EBI-527224|ensembl:ENSMUSP00000084701	psi-mi:kgp1_mouse(display_long)|uniprotkb:Prkg1(gene name)|psi-mi:Prkg1(display_short)|uniprotkb:Prkgr1a(gene name synonym)|uniprotkb:Prkg1b(gene name synonym)|uniprotkb:Prkgr1b(gene name synonym)|uniprotkb:cGMP-dependent protein kinase I(gene name synonym)	psi-mi:bmpr2_mouse(display_long)|uniprotkb:Bone morphogenetic protein receptor type II(gene name synonym)|uniprotkb:BRK-3(gene name synonym)|uniprotkb:Bmpr2(gene name)|psi-mi:Bmpr2(display_short)	psi-mi:"MI:0096"(pull down)	Schwappacher et al. (2009)	pubmed:19424179|imex:IM-13879|mint:MINT-7289369|doi:10.1038/emboj.2009.103	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-6992321|mint:MINT-7289449|imex:IM-13879-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006526831.1|ensembl:ENSMUSG00000052920(gene)|ensembl:ENSMUST00000065067(transcript)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0001764"(neuron migration)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004692"(cGMP-dependent protein kinase activity)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0010920"(negative regulation of inositol phosphate biosynthetic process)|go:"GO:0014050"(negative regulation of glutamate secretion)|go:"GO:0014912"(negative regulation of smooth muscle cell migration)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0019934"(cGMP-mediated signaling)|go:"GO:0030553"(cGMP binding)|go:"GO:0030900"(forebrain development)|go:"GO:0042311"(vasodilation)|go:"GO:0042753"(positive regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0045822"(negative regulation of heart contraction)|go:"GO:0045986"(negative regulation of smooth muscle contraction)|go:"GO:0048273"(mitogen-activated protein kinase p38 binding)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0061049"(cell growth involved in cardiac muscle cell development)|go:"GO:0090331"(negative regulation of platelet aggregation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902608"(positive regulation of large conductance calcium-activated potassium channel activity)|go:"GO:1904753"(negative regulation of vascular associated smooth muscle cell migration)|go:"GO:2000224"(regulation of testosterone biosynthetic process)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR002374(cGMP-dependent protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR018488|interpro:IPR018490|interpro:IPR031831|interpro:IPR035014|mint:P0C605|reactome:R-MMU-392517|reactome:R-MMU-418457|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|refseq:NP_001013855.1|refseq:NP_035290.1|dip:DIP-29981N|mint:MINT-7289455(identity)	ensembl:ENSMUSG00000067336(gene)|ensembl:ENSMUST00000087435(transcript)|go:"GO:0001568"(blood vessel development)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001893"(maternal placenta development)|go:"GO:0001935"(endothelial cell proliferation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001946"(lymphangiogenesis)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002063"(chondrocyte development)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003176"(aortic valve development)|go:"GO:0003177"(pulmonary valve development)|go:"GO:0003183"(mitral valve morphogenesis)|go:"GO:0003186"(tricuspid valve morphogenesis)|go:"GO:0003197"(endocardial cushion development)|go:"GO:0003252"(negative regulation of cell proliferation involved in heart valve morphogenesis)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005024"(transforming growth factor beta-activated receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005912"(adherens junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007178"(transmembrane receptor protein serine/threonine kinase signaling pathway)|go:"GO:0007420"(brain development)|go:"GO:0009267"(cellular response to starvation)|refseq:NP_031587.1|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014916"(regulation of lung blood pressure)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019211"(phosphatase activator activity)|go:"GO:0019838"(growth factor binding)|go:"GO:0030166"(proteoglycan biosynthetic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0030546"(signaling receptor activator activity)|go:"GO:0036122"(BMP binding)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043235"(receptor complex)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045296"(cadherin binding)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045778"(positive regulation of ossification)|go:"GO:0045906"(negative regulation of vasoconstriction)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048286"(lung alveolus development)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0048842"(positive regulation of axon extension involved in axon guidance)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0060173"(limb development)|go:"GO:0060350"(endochondral bone morphogenesis)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060413"(atrial septum morphogenesis)|go:"GO:0060836"(lymphatic endothelial cell differentiation)|go:"GO:0060840"(artery development)|go:"GO:0060841"(venous blood vessel development)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0061298"(retina vasculature development in camera-type eye)|go:"GO:0061626"(pharyngeal arch artery morphogenesis)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0098821"(BMP receptor activity)|go:"GO:0140537"(transcription regulator activator activity)|go:"GO:1902731"(negative regulation of chondrocyte proliferation)|go:"GO:1905314"(semi-lunar valve development)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000279"(negative regulation of DNA biosynthetic process)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000333(Activin type II receptor)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015770(Bone morphogenic protein type II receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:O35607|reactome:R-MMU-201451|mint:MINT-7289451(identity)	-	comment:mint	-	figure legend:F1D|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/10/08	2014/10/16	rogid:P+szNlUos2Nnfev1xiY4J5ztVTQ10090	rogid:4Dbgj6TEhtrX/9jydmufYNfEh1M10090	intact-crc:4E9A53C109E655A5|rigid:XpLnjBUjFZc+5bempwU09bp4378	false	maltose binding protein tag:?-?(MINT-7289459)	glutathione s tranferase tag:?-?(MINT-7289452)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q13976	uniprotkb:Q13873	intact:EBI-3952014|uniprotkb:Q6P5T7|uniprotkb:E2PU10|uniprotkb:P14619|uniprotkb:Q5JSJ6|ensembl:ENSP00000384200|uniprotkb:A5YM56|uniprotkb:B3KSF3|uniprotkb:Q5JP05	intact:EBI-527196|uniprotkb:Q16569|uniprotkb:Q13161|uniprotkb:Q4ZG08|uniprotkb:Q53SA5|uniprotkb:Q585T8|ensembl:ENSP00000363708	psi-mi:kgp1_human(display_long)|uniprotkb:PRKG1(gene name)|psi-mi:PRKG1(display_short)|uniprotkb:PRKG1B(gene name synonym)|uniprotkb:PRKGR1A(gene name synonym)|uniprotkb:PRKGR1B(gene name synonym)|uniprotkb:cGMP-dependent protein kinase I(gene name synonym)	psi-mi:bmpr2_human(display_long)|uniprotkb:Bone morphogenetic protein receptor type II(gene name synonym)|uniprotkb:PPH1(gene name synonym)|uniprotkb:BMPR2(gene name)|psi-mi:BMPR2(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Schwappacher et al. (2009)	pubmed:19424179|imex:IM-13879|mint:MINT-7289369|doi:10.1038/emboj.2009.103	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-6992363|mint:MINT-7289591|imex:IM-13879-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR018488|interpro:IPR018490|interpro:IPR031831|interpro:IPR035014|mint:Q13976|rcsb pdb:1ZXA|rcsb pdb:3NMD|rcsb pdb:3OCP|rcsb pdb:3OD0|rcsb pdb:3OGJ|rcsb pdb:4KU7|rcsb pdb:4KU8|rcsb pdb:4QX5|rcsb pdb:4QXK|rcsb pdb:4R4L|rcsb pdb:4R4M|rcsb pdb:4Z07|rcsb pdb:5J48|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:5JAX|rcsb pdb:5JD7|rcsb pdb:5L0N|rcsb pdb:6BDL|rcsb pdb:6BG2|rcsb pdb:6C0T|reactome:R-HSA-392517|reactome:R-HSA-4086398|reactome:R-HSA-418457|refseq:NP_001091982.1|refseq:NP_006249.1|ensembl:ENST00000401604(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004692"(cGMP-dependent protein kinase activity)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0016358"(dendrite development)|go:"GO:0019934"(cGMP-mediated signaling)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030553"(cGMP binding)|go:"GO:0030900"(forebrain development)|go:"GO:0042802"(identical protein binding)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0090331"(negative regulation of platelet aggregation)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904753"(negative regulation of vascular associated smooth muscle cell migration)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR002374(cGMP-dependent protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR014710(RmlC-like jelly roll fold)|ensembl:ENSG00000185532(gene)|dip:DIP-41118N|dip:DIP-46288N|mint:MINT-7289597(identity)	dip:DIP-5794N|refseq:NP_001195.2|ensembl:ENSG00000204217(gene)|ensembl:ENST00000374580(transcript)|go:"GO:0001568"(blood vessel development)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001893"(maternal placenta development)|go:"GO:0001935"(endothelial cell proliferation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001946"(lymphangiogenesis)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002063"(chondrocyte development)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003176"(aortic valve development)|go:"GO:0003177"(pulmonary valve development)|go:"GO:0003183"(mitral valve morphogenesis)|go:"GO:0003186"(tricuspid valve morphogenesis)|go:"GO:0003197"(endocardial cushion development)|go:"GO:0003252"(negative regulation of cell proliferation involved in heart valve morphogenesis)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005024"(transforming growth factor beta-activated receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005912"(adherens junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007178"(transmembrane receptor protein serine/threonine kinase signaling pathway)|go:"GO:0007420"(brain development)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0014916"(regulation of lung blood pressure)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016362"(activin receptor activity, type II)|go:"GO:0019211"(phosphatase activator activity)|go:"GO:0019838"(growth factor binding)|go:"GO:0030166"(proteoglycan biosynthetic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0030546"(signaling receptor activator activity)|go:"GO:0036122"(BMP binding)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043235"(receptor complex)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0044214"(spanning component of plasma membrane)|go:"GO:0045296"(cadherin binding)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045778"(positive regulation of ossification)|go:"GO:0045906"(negative regulation of vasoconstriction)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048286"(lung alveolus development)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0048842"(positive regulation of axon extension involved in axon guidance)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0060173"(limb development)|go:"GO:0060350"(endochondral bone morphogenesis)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060413"(atrial septum morphogenesis)|go:"GO:0060836"(lymphatic endothelial cell differentiation)|go:"GO:0060840"(artery development)|go:"GO:0060841"(venous blood vessel development)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0061298"(retina vasculature development in camera-type eye)|go:"GO:0061626"(pharyngeal arch artery morphogenesis)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0014069"(postsynaptic density)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0098821"(BMP receptor activity)|go:"GO:0140537"(transcription regulator activator activity)|go:"GO:1902731"(negative regulation of chondrocyte proliferation)|go:"GO:1905314"(semi-lunar valve development)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000279"(negative regulation of DNA biosynthetic process)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015770(Bone morphogenic protein type II receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q13873|rcsb pdb:2HLQ|rcsb pdb:3G2F|reactome:R-HSA-201451|go:"GO:0071773"(cellular response to BMP stimulus)|mint:MINT-7289593(identity)	-	caution:This sequence has been withdrawn from Uniprot.|crc64:51389502A5E5FBD2	-	figure legend:F3B|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2009/10/08	2014/10/16	rogid:FFagskyghjyYPihsoL8JaO0RXgY9606	rogid:ZnEZsCvOyBegC07WvkGwXMz6jAw9606	intact-crc:7C5481973BB0179F|rigid:dtQ2OTTWv+8iUzk63kV6BTqgjBU	false	-	ha tag:?-?(MINT-7289594)	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P70340	uniprotkb:P0C605	intact:EBI-6992047|ensembl:ENSMUSP00000071035|uniprotkb:Q6GT95|uniprotkb:P70442|uniprotkb:Q9CYK6|intact:MINT-99213	intact:EBI-6991999|ensembl:ENSMUSP00000067576|intact:MINT-7289393|uniprotkb:Q9Z0Z0|uniprotkb:Q14DK6|intact:UNK-5561184	psi-mi:smad1_mouse(display_long)|uniprotkb:Smad1(gene name)|psi-mi:Smad1(display_short)|uniprotkb:Madh1(gene name synonym)|uniprotkb:Madr1(gene name synonym)|uniprotkb:Mothers-against-DPP-related 1(gene name synonym)|uniprotkb:Dwarfin-A(gene name synonym)|uniprotkb:SMAD family member 1(gene name synonym)	psi-mi:kgp1_mouse(display_long)|uniprotkb:Prkg1(gene name)|psi-mi:Prkg1(display_short)|uniprotkb:Prkgr1a(gene name synonym)|uniprotkb:Prkg1b(gene name synonym)|uniprotkb:Prkgr1b(gene name synonym)|uniprotkb:cGMP-dependent protein kinase I(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Schwappacher et al. (2009)	pubmed:19424179|imex:IM-13879|mint:MINT-7289369|doi:10.1038/emboj.2009.103	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-6992387|mint:MINT-7289489|imex:IM-13879-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006530809.1|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009880"(embryonic pattern specification)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0017151"(DEAD/H-box RNA helicase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030901"(midbrain development)|go:"GO:0006954"(inflammatory response)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0030902"(hindbrain development)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042493"|go:"GO:0042592"(homeostatic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0051216"(cartilage development)|go:"GO:0060038"(cardiac muscle cell proliferation)|go:"GO:0060348"(bone development)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0007276"(gamete generation)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0070410"(co-SMAD binding)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|mint:P70340|rcsb pdb:3KMP|reactome:R-MMU-201451|reactome:R-MMU-5689880|reactome:R-MMU-8941326|ensembl:ENSMUSG00000031681(gene)|ensembl:ENSMUST00000066091(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001657"(ureteric bud development)|go:"GO:0001710"(mesodermal cell fate commitment)|go:"GO:0002051"(osteoblast fate commitment)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006468"(protein phosphorylation)|refseq:NP_032565.2|mint:MINT-7289491(identity)	refseq:XP_006526831.1|ensembl:ENSMUSG00000052920(gene)|ensembl:ENSMUST00000065067(transcript)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0001764"(neuron migration)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004692"(cGMP-dependent protein kinase activity)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0010920"(negative regulation of inositol phosphate biosynthetic process)|go:"GO:0014050"(negative regulation of glutamate secretion)|go:"GO:0014912"(negative regulation of smooth muscle cell migration)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0019934"(cGMP-mediated signaling)|go:"GO:0030553"(cGMP binding)|go:"GO:0030900"(forebrain development)|go:"GO:0042311"(vasodilation)|go:"GO:0042753"(positive regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0045822"(negative regulation of heart contraction)|go:"GO:0045986"(negative regulation of smooth muscle contraction)|go:"GO:0048273"(mitogen-activated protein kinase p38 binding)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0061049"(cell growth involved in cardiac muscle cell development)|go:"GO:0090331"(negative regulation of platelet aggregation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902608"(positive regulation of large conductance calcium-activated potassium channel activity)|go:"GO:1904753"(negative regulation of vascular associated smooth muscle cell migration)|go:"GO:2000224"(regulation of testosterone biosynthetic process)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR002374(cGMP-dependent protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR018488|interpro:IPR018490|interpro:IPR031831|interpro:IPR035014|mint:P0C605|reactome:R-MMU-392517|reactome:R-MMU-418457|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|refseq:NP_001013855.1|refseq:NP_035290.1|dip:DIP-29981N|mint:MINT-7289493(identity)	go:"GO:0005634"(nucleus)	comment:mint|function:"Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD1 is a receptor-regulated SMAD (R-SMAD) (By similarity). May play a role in the initiation and maintenance of spermatogenesis"	comment:mint	figure legend:F4C|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-c2c12)|taxid:10090(Mouse C3H muscle myoblast)	-	2009/10/08	2014/10/16	rogid:D3Mhh31YZUsykSUfzewNuy8NyrY10090	rogid:P+szNlUos2Nnfev1xiY4J5ztVTQ10090	intact-crc:894D67085B07AF2B|rigid:EhIg9mvaZ94ezcMsdooWh6AeJpo	false	-	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:P0C605	uniprotkb:P97471	intact:EBI-6991999|ensembl:ENSMUSP00000067576|intact:MINT-7289393|uniprotkb:Q9Z0Z0|uniprotkb:Q14DK6|intact:UNK-5561184	intact:EBI-5259270|uniprotkb:Q6GTP6|uniprotkb:Q9CW56|ensembl:ENSMUSP00000025393|ensembl:ENSMUSP00000110589	psi-mi:kgp1_mouse(display_long)|uniprotkb:Prkg1(gene name)|psi-mi:Prkg1(display_short)|uniprotkb:Prkgr1a(gene name synonym)|uniprotkb:Prkg1b(gene name synonym)|uniprotkb:Prkgr1b(gene name synonym)|uniprotkb:cGMP-dependent protein kinase I(gene name synonym)	psi-mi:smad4_mouse(display_long)|uniprotkb:Smad4(gene name)|psi-mi:Smad4(display_short)|uniprotkb:Dpc4(gene name synonym)|uniprotkb:Madh4(gene name synonym)|uniprotkb:Deletion target in pancreatic carcinoma 4 homolog(gene name synonym)|uniprotkb:SMAD family member 4(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Schwappacher et al. (2009)	pubmed:19424179|imex:IM-13879|mint:MINT-7289369|doi:10.1038/emboj.2009.103	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-6992416|mint:MINT-7289502|imex:IM-13879-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006526831.1|ensembl:ENSMUSG00000052920(gene)|ensembl:ENSMUST00000065067(transcript)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0001764"(neuron migration)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004692"(cGMP-dependent protein kinase activity)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0010920"(negative regulation of inositol phosphate biosynthetic process)|go:"GO:0014050"(negative regulation of glutamate secretion)|go:"GO:0014912"(negative regulation of smooth muscle cell migration)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0019934"(cGMP-mediated signaling)|go:"GO:0030553"(cGMP binding)|go:"GO:0030900"(forebrain development)|go:"GO:0042311"(vasodilation)|go:"GO:0042753"(positive regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0045822"(negative regulation of heart contraction)|go:"GO:0045986"(negative regulation of smooth muscle contraction)|go:"GO:0048273"(mitogen-activated protein kinase p38 binding)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0061049"(cell growth involved in cardiac muscle cell development)|go:"GO:0090331"(negative regulation of platelet aggregation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902608"(positive regulation of large conductance calcium-activated potassium channel activity)|go:"GO:1904753"(negative regulation of vascular associated smooth muscle cell migration)|go:"GO:2000224"(regulation of testosterone biosynthetic process)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR002374(cGMP-dependent protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR018488|interpro:IPR018490|interpro:IPR031831|interpro:IPR035014|mint:P0C605|reactome:R-MMU-392517|reactome:R-MMU-418457|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|refseq:NP_001013855.1|refseq:NP_035290.1|dip:DIP-29981N|mint:MINT-7289507(identity)	refseq:NP_032566.2|dip:DIP-29718N|ensembl:ENSMUSG00000024515(gene)|ensembl:ENSMUST00000025393(transcript)|ensembl:ENSMUST00000114939(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0001822"(kidney development)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003190"(atrioventricular valve formation)|go:"GO:0003198"(epithelial to mesenchymal transition involved in endocardial cushion formation)|go:"GO:0003220"(left ventricular cardiac muscle tissue morphogenesis)|go:"GO:0003251"(positive regulation of cell proliferation involved in heart valve morphogenesis)|go:"GO:0003279"(cardiac septum development)|go:"GO:0003360"(brainstem development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005518"(collagen binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006879"(cellular iron ion homeostasis)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007183"(SMAD protein complex assembly)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0007369"(gastrulation)|go:"GO:0007411"(axon guidance)|go:"GO:0007492"(endoderm development)|go:"GO:0007498"(mesoderm development)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008584"(male gonad development)|go:"GO:0008585"(female gonad development)|go:"GO:0009653"(anatomical structure morphogenesis)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0014033"(neural crest cell differentiation)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030154"(cell differentiation)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0031005"(filamin binding)|go:"GO:0032444"(activin responsive factor complex)|go:"GO:0032525"(somite rostral/caudal axis specification)|go:"GO:0032909"(regulation of transforming growth factor beta2 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033686"(positive regulation of luteinizing hormone secretion)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036302"(atrioventricular canal development)|go:"GO:0042060"(wound healing)|go:"GO:0042118"(endothelial cell activation)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043199"(sulfate binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0046881"(positive regulation of follicle-stimulating hormone secretion)|go:"GO:0048382"(mesendoderm development)|go:"GO:0048589"(developmental growth)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048729"(tissue morphogenesis)|go:"GO:0048733"(sebaceous gland development)|go:"GO:0048859"(formation of anatomical boundary)|go:"GO:0051098"(regulation of binding)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051797"(regulation of hair follicle development)|go:"GO:0060065"(uterus development)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0060956"(endocardial cell differentiation)|go:"GO:0061040"(female gonad morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0062009"(secondary palate development)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0071141"(SMAD protein complex)|go:"GO:0071144"(heteromeric SMAD protein complex)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071559"(response to transforming growth factor beta)|go:"GO:0072133"(metanephric mesenchyme morphogenesis)|go:"GO:0072134"(nephrogenic mesenchyme morphogenesis)|go:"GO:0072520"(seminiferous tubule development)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1905305"(negative regulation of cardiac myofibril assembly)|go:"GO:2000617"(positive regulation of histone H3-K9 acetylation)|interpro:IPR001132(SMAD domain, Dwarfin-type)|interpro:IPR003619(MAD homology 1, Dwarfin-type)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013019(MAD homology, MH1)|interpro:IPR013790(Dwarfin)|interpro:IPR017855(SMAD domain-like)|interpro:IPR036578|mint:P97471|rcsb pdb:3QSV|reactome:R-MMU-1181150|reactome:R-MMU-1502540|reactome:R-MMU-201451|reactome:R-MMU-2173789|reactome:R-MMU-2173795|reactome:R-MMU-2173796|reactome:R-MMU-5689880|reactome:R-MMU-8941326|reactome:R-MMU-8941855|reactome:R-MMU-9617828|mint:MINT-7289505(identity)	go:"GO:0005634"(nucleus)	comment:mint	-	figure legend:F4C|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-c2c12)|taxid:10090(Mouse C3H muscle myoblast)	-	2009/10/08	2014/10/16	rogid:P+szNlUos2Nnfev1xiY4J5ztVTQ10090	rogid:IJFXHvSWr9ahHMgHAekwlFtH57w10090	intact-crc:BC0F1DABF65BF83E|rigid:VXPCLo5nxPgna5eszFUI4i1d6EE	false	-	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:P0C605	uniprotkb:O35607	intact:EBI-6991999|ensembl:ENSMUSP00000067576|intact:MINT-7289393|uniprotkb:Q9Z0Z0|uniprotkb:Q14DK6|intact:UNK-5561184	intact:EBI-527224|ensembl:ENSMUSP00000084701	psi-mi:kgp1_mouse(display_long)|uniprotkb:Prkg1(gene name)|psi-mi:Prkg1(display_short)|uniprotkb:Prkgr1a(gene name synonym)|uniprotkb:Prkg1b(gene name synonym)|uniprotkb:Prkgr1b(gene name synonym)|uniprotkb:cGMP-dependent protein kinase I(gene name synonym)	psi-mi:bmpr2_mouse(display_long)|uniprotkb:Bone morphogenetic protein receptor type II(gene name synonym)|uniprotkb:BRK-3(gene name synonym)|uniprotkb:Bmpr2(gene name)|psi-mi:Bmpr2(display_short)	psi-mi:"MI:0424"(protein kinase assay)	Schwappacher et al. (2009)	pubmed:19424179|imex:IM-13879|mint:MINT-7289369|doi:10.1038/emboj.2009.103	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-6992439|mint:MINT-7289462|imex:IM-13879-1	-	-	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006526831.1|ensembl:ENSMUSG00000052920(gene)|ensembl:ENSMUST00000065067(transcript)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0001764"(neuron migration)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004692"(cGMP-dependent protein kinase activity)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0010920"(negative regulation of inositol phosphate biosynthetic process)|go:"GO:0014050"(negative regulation of glutamate secretion)|go:"GO:0014912"(negative regulation of smooth muscle cell migration)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0019934"(cGMP-mediated signaling)|go:"GO:0030553"(cGMP binding)|go:"GO:0030900"(forebrain development)|go:"GO:0042311"(vasodilation)|go:"GO:0042753"(positive regulation of circadian rhythm)|go:"GO:0042802"(identical protein binding)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0045822"(negative regulation of heart contraction)|go:"GO:0045986"(negative regulation of smooth muscle contraction)|go:"GO:0048273"(mitogen-activated protein kinase p38 binding)|go:"GO:0060087"(relaxation of vascular associated smooth muscle)|go:"GO:0061049"(cell growth involved in cardiac muscle cell development)|go:"GO:0090331"(negative regulation of platelet aggregation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902608"(positive regulation of large conductance calcium-activated potassium channel activity)|go:"GO:1904753"(negative regulation of vascular associated smooth muscle cell migration)|go:"GO:2000224"(regulation of testosterone biosynthetic process)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR002374(cGMP-dependent protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR018488|interpro:IPR018490|interpro:IPR031831|interpro:IPR035014|mint:P0C605|reactome:R-MMU-392517|reactome:R-MMU-418457|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|refseq:NP_001013855.1|refseq:NP_035290.1|dip:DIP-29981N|mint:MINT-7289464(identity)	ensembl:ENSMUSG00000067336(gene)|ensembl:ENSMUST00000087435(transcript)|go:"GO:0001568"(blood vessel development)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001893"(maternal placenta development)|go:"GO:0001935"(endothelial cell proliferation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001946"(lymphangiogenesis)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002063"(chondrocyte development)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003176"(aortic valve development)|go:"GO:0003177"(pulmonary valve development)|go:"GO:0003183"(mitral valve morphogenesis)|go:"GO:0003186"(tricuspid valve morphogenesis)|go:"GO:0003197"(endocardial cushion development)|go:"GO:0003252"(negative regulation of cell proliferation involved in heart valve morphogenesis)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005024"(transforming growth factor beta-activated receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005912"(adherens junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007178"(transmembrane receptor protein serine/threonine kinase signaling pathway)|go:"GO:0007420"(brain development)|go:"GO:0009267"(cellular response to starvation)|refseq:NP_031587.1|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014916"(regulation of lung blood pressure)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019211"(phosphatase activator activity)|go:"GO:0019838"(growth factor binding)|go:"GO:0030166"(proteoglycan biosynthetic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0030546"(signaling receptor activator activity)|go:"GO:0036122"(BMP binding)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043235"(receptor complex)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045296"(cadherin binding)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045778"(positive regulation of ossification)|go:"GO:0045906"(negative regulation of vasoconstriction)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048286"(lung alveolus development)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0048842"(positive regulation of axon extension involved in axon guidance)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0060173"(limb development)|go:"GO:0060350"(endochondral bone morphogenesis)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060413"(atrial septum morphogenesis)|go:"GO:0060836"(lymphatic endothelial cell differentiation)|go:"GO:0060840"(artery development)|go:"GO:0060841"(venous blood vessel development)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0061298"(retina vasculature development in camera-type eye)|go:"GO:0061626"(pharyngeal arch artery morphogenesis)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0098821"(BMP receptor activity)|go:"GO:0140537"(transcription regulator activator activity)|go:"GO:1902731"(negative regulation of chondrocyte proliferation)|go:"GO:1905314"(semi-lunar valve development)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000279"(negative regulation of DNA biosynthetic process)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000333(Activin type II receptor)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015770(Bone morphogenic protein type II receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:O35607|reactome:R-MMU-201451|mint:MINT-7289468(identity)	-	comment:mint	-	figure legend:F2|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/10/08	2014/10/16	rogid:P+szNlUos2Nnfev1xiY4J5ztVTQ10090	rogid:4Dbgj6TEhtrX/9jydmufYNfEh1M10090	intact-crc:EE75E6D464251B3D|rigid:XpLnjBUjFZc+5bempwU09bp4378	false	-	glutathione s tranferase tag:?-?(MINT-7289469)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)