#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P31327	uniprotkb:Q8K2C6	intact:EBI-536811|uniprotkb:O43774|uniprotkb:Q7Z5I5|uniprotkb:B7Z818|uniprotkb:Q53TL5|uniprotkb:J3KQL0|uniprotkb:Q59HF8|ensembl:ENSP00000233072|ensembl:ENSP00000500537|ensembl:ENSP00000501022|ensembl:ENSP00000501073	intact:EBI-2348809|ensembl:ENSMUSP00000071048|ensembl:ENSMUSP00000152796	psi-mi:cpsm_human(display_long)|uniprotkb:Carbamoyl-phosphate synthetase I(gene name synonym)|uniprotkb:CPS1(gene name)|psi-mi:CPS1(display_short)	psi-mi:sir5_mouse(display_long)|uniprotkb:Sirt5(gene name)|psi-mi:Sirt5(display_short)|uniprotkb:Sir2l5(gene name synonym)|uniprotkb:SIR2-like protein 5(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 5(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Nakagawa et al. (2009)	imex:IM-12184|pubmed:19410549	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2353227|imex:IM-12184-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001116105.1|refseq:NP_001116106.1|refseq:NP_001866.2|refseq:XP_011508943.1|refseq:XP_011508944.1|refseq:XP_011508945.1|refseq:XP_011508946.1|ensembl:ENSG00000021826(gene)|ensembl:ENST00000233072(transcript)|ensembl:ENST00000673510(transcript)|ensembl:ENST00000673630(transcript)|ensembl:ENST00000673711(transcript)|go:"GO:0000050"(urea cycle)|go:"GO:0004087"("carbamoyl-phosphate synthase (ammonia) activity")|go:"GO:0004088"("carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity")|go:"GO:0004175"(endopeptidase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0006207"('de novo' pyrimidine nucleobase biosynthetic process)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006807"(nitrogen compound metabolic process)|go:"GO:0007494"(midgut development)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010043"(response to zinc ion)|go:"GO:0014075"(response to amine)|go:"GO:0016595"(glutamate binding)|go:"GO:0019240"(citrulline biosynthetic process)|go:"GO:0019433"(triglyceride catabolic process)|go:"GO:0032094"(response to food)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0042594"(response to starvation)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0043200"(response to amino acid)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046209"(nitric oxide metabolic process)|go:"GO:0050667"(homocysteine metabolic process)|go:"GO:0055081"(anion homeostasis)|go:"GO:0060416"(response to growth hormone)|go:"GO:0070365"(hepatocyte differentiation)|go:"GO:0070409"(carbamoyl phosphate biosynthetic process)|go:"GO:0071242"(cellular response to ammonium ion)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071377"(cellular response to glucagon stimulus)|go:"GO:0071400"(cellular response to oleic acid)|go:"GO:0071548"(response to dexamethasone)|go:"GO:0072341"(modified amino acid binding)|interpro:IPR002474(Carbamoyl phosphate synthase, small subunit, N-terminal)|interpro:IPR005479(Carbamoyl phosphate synthetase, large subunit, ATP-binding)|interpro:IPR005480(Carbamoyl phosphate synthetase, large subunit, oligomerisation)|interpro:IPR005483(Carbamoyl phosphate synthase, large subunit)|interpro:IPR006274(Carbamoyl phosphate synthase, small subunit)|interpro:IPR006275(Carbamoyl phosphate synthase, large subunit, glutamine-dependent)|interpro:IPR011607(MGS-like)|interpro:IPR011761(ATP-grasp fold)|interpro:IPR013815(ATP-grasp fold, subdomain 1)|interpro:IPR016185(PreATP-grasp-like fold)|interpro:IPR017926|interpro:IPR029062|interpro:IPR035686|interpro:IPR036480|interpro:IPR036897|interpro:IPR036914|mint:P31327|rcsb pdb:2YVQ|rcsb pdb:4UTR|rcsb pdb:4UTV|rcsb pdb:4UTX|rcsb pdb:4UTZ|rcsb pdb:4UU7|rcsb pdb:4UU8|rcsb pdb:4UUA|rcsb pdb:4UUB|rcsb pdb:5DOT|rcsb pdb:5DOU|rcsb pdb:5OJO|rcsb pdb:6UEL|rcsb pdb:6W2J|reactome:R-HSA-70635	refseq:NP_849179.1|ensembl:ENSMUSG00000054021(gene)|ensembl:ENSMUST00000066804(transcript)|ensembl:ENSMUST00000223194(transcript)|go:"GO:0002931"(response to ischemia)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010566"(regulation of ketone biosynthetic process)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0016740"(transferase activity)|go:"GO:0036046"(protein demalonylation)|go:"GO:0036047"(peptidyl-lysine demalonylation)|go:"GO:0036048"(protein desuccinylation)|go:"GO:0036049"(peptidyl-lysine desuccinylation)|go:"GO:0036054"(protein-malonyllysine demalonylase activity)|go:"GO:0036055"(protein-succinyllysine desuccinylase activity)|go:"GO:0061698"(protein deglutarylation)|go:"GO:0070403"(NAD+ binding)|go:"GO:1904229"(regulation of succinate dehydrogenase activity)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR026590|interpro:IPR026591|interpro:IPR027546|interpro:IPR029035|mint:Q8K2C6|reactome:R-MMU-2151201|go:"GO:0061697"(protein-glutaryllysine deglutarylase activity)	go:"GO:0005759"(mitochondrial matrix)	-	-	figure legend:Fig. 2A, 2B, Supp. Fig. 3|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/06/10	2014/10/16	rogid:497s02igPCWuQcU4lVrMpl5SRig9606	rogid:PWG9j7k8N9X9cBJOfVnkLgYzH9E10090	intact-crc:401FF176981E53B5|rigid:wc6QH24mSSjmB3qFBR17RKTyrNI	false	-	flag tag:?-?	-	-	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)	psi-mi:"MI:0032"(de novo protein sequencing by mass spectrometry)
uniprotkb:Q8C196	uniprotkb:Q8K2C6	intact:EBI-2348828|uniprotkb:Q6NX75|uniprotkb:A0JNU4|ensembl:ENSMUSP00000027144	intact:EBI-2348809|ensembl:ENSMUSP00000071048|ensembl:ENSMUSP00000152796	psi-mi:cpsm_mouse(display_long)|uniprotkb:Cps1(gene name)|psi-mi:Cps1(display_short)|uniprotkb:Carbamoyl-phosphate synthetase I(gene name synonym)	psi-mi:sir5_mouse(display_long)|uniprotkb:Sirt5(gene name)|psi-mi:Sirt5(display_short)|uniprotkb:Sir2l5(gene name synonym)|uniprotkb:SIR2-like protein 5(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 5(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Nakagawa et al. (2009)	imex:IM-12184|pubmed:19410549	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2353319|imex:IM-12184-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011236802.1|refseq:NP_001074278.1|ensembl:ENSMUSG00000025991(gene)|ensembl:ENSMUST00000027144(transcript)|go:"GO:0000050"(urea cycle)|go:"GO:0004087"("carbamoyl-phosphate synthase (ammonia) activity")|go:"GO:0004088"("carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity")|go:"GO:0004175"(endopeptidase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006207"('de novo' pyrimidine nucleobase biosynthetic process)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006807"(nitrogen compound metabolic process)|go:"GO:0007494"(midgut development)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010043"(response to zinc ion)|go:"GO:0014075"(response to amine)|go:"GO:0016595"(glutamate binding)|go:"GO:0019433"(triglyceride catabolic process)|go:"GO:0032094"(response to food)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0042594"(response to starvation)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0043200"(response to amino acid)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046209"(nitric oxide metabolic process)|go:"GO:0050667"(homocysteine metabolic process)|go:"GO:0055081"(anion homeostasis)|go:"GO:0060416"(response to growth hormone)|go:"GO:0070365"(hepatocyte differentiation)|go:"GO:0070409"(carbamoyl phosphate biosynthetic process)|go:"GO:0071242"(cellular response to ammonium ion)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071377"(cellular response to glucagon stimulus)|go:"GO:0071400"(cellular response to oleic acid)|go:"GO:0071548"(response to dexamethasone)|go:"GO:0072341"(modified amino acid binding)|interpro:IPR002474(Carbamoyl phosphate synthase, small subunit, N-terminal)|interpro:IPR005479(Carbamoyl phosphate synthetase, large subunit, ATP-binding)|interpro:IPR005480(Carbamoyl phosphate synthetase, large subunit, oligomerisation)|interpro:IPR005483(Carbamoyl phosphate synthase, large subunit)|interpro:IPR006274(Carbamoyl phosphate synthase, small subunit)|interpro:IPR006275(Carbamoyl phosphate synthase, large subunit, glutamine-dependent)|interpro:IPR011607(MGS-like)|interpro:IPR011761(ATP-grasp fold)|interpro:IPR013815(ATP-grasp fold, subdomain 1)|interpro:IPR016185(PreATP-grasp-like fold)|interpro:IPR017926|interpro:IPR029062|interpro:IPR035686|interpro:IPR036480|interpro:IPR036897|interpro:IPR036914|mint:Q8C196|reactome:R-MMU-70635	refseq:NP_849179.1|ensembl:ENSMUSG00000054021(gene)|ensembl:ENSMUST00000066804(transcript)|ensembl:ENSMUST00000223194(transcript)|go:"GO:0002931"(response to ischemia)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010566"(regulation of ketone biosynthetic process)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0016740"(transferase activity)|go:"GO:0036046"(protein demalonylation)|go:"GO:0036047"(peptidyl-lysine demalonylation)|go:"GO:0036048"(protein desuccinylation)|go:"GO:0036049"(peptidyl-lysine desuccinylation)|go:"GO:0036054"(protein-malonyllysine demalonylase activity)|go:"GO:0036055"(protein-succinyllysine desuccinylase activity)|go:"GO:0061698"(protein deglutarylation)|go:"GO:0070403"(NAD+ binding)|go:"GO:1904229"(regulation of succinate dehydrogenase activity)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR026590|interpro:IPR026591|interpro:IPR027546|interpro:IPR029035|mint:Q8K2C6|reactome:R-MMU-2151201|go:"GO:0061697"(protein-glutaryllysine deglutarylase activity)	go:"GO:0005759"(mitochondrial matrix)	-	-	figure legend:Fig. 2C|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/06/10	2014/10/16	rogid:rF6N6MgpvcLpTEy98xLg4/NqUCY10090	rogid:PWG9j7k8N9X9cBJOfVnkLgYzH9E10090	intact-crc:A471528C6E54DCAC|rigid:klMr3i9i+Hs/iP6i7tiYsJOrs9g	false	-	flag tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8K2C6	uniprotkb:Q8C196	intact:EBI-2348809|ensembl:ENSMUSP00000071048|ensembl:ENSMUSP00000152796	intact:EBI-2348828|uniprotkb:Q6NX75|uniprotkb:A0JNU4|ensembl:ENSMUSP00000027144	psi-mi:sir5_mouse(display_long)|uniprotkb:Sirt5(gene name)|psi-mi:Sirt5(display_short)|uniprotkb:Sir2l5(gene name synonym)|uniprotkb:SIR2-like protein 5(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 5(gene name synonym)	psi-mi:cpsm_mouse(display_long)|uniprotkb:Cps1(gene name)|psi-mi:Cps1(display_short)|uniprotkb:Carbamoyl-phosphate synthetase I(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Nakagawa et al. (2009)	imex:IM-12184|pubmed:19410549	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2353334|imex:IM-12184-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_849179.1|ensembl:ENSMUSG00000054021(gene)|ensembl:ENSMUST00000066804(transcript)|ensembl:ENSMUST00000223194(transcript)|go:"GO:0002931"(response to ischemia)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010566"(regulation of ketone biosynthetic process)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0016740"(transferase activity)|go:"GO:0036046"(protein demalonylation)|go:"GO:0036047"(peptidyl-lysine demalonylation)|go:"GO:0036048"(protein desuccinylation)|go:"GO:0036049"(peptidyl-lysine desuccinylation)|go:"GO:0036054"(protein-malonyllysine demalonylase activity)|go:"GO:0036055"(protein-succinyllysine desuccinylase activity)|go:"GO:0061698"(protein deglutarylation)|go:"GO:0070403"(NAD+ binding)|go:"GO:1904229"(regulation of succinate dehydrogenase activity)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR026590|interpro:IPR026591|interpro:IPR027546|interpro:IPR029035|mint:Q8K2C6|reactome:R-MMU-2151201|go:"GO:0061697"(protein-glutaryllysine deglutarylase activity)	refseq:XP_011236802.1|refseq:NP_001074278.1|ensembl:ENSMUSG00000025991(gene)|ensembl:ENSMUST00000027144(transcript)|go:"GO:0000050"(urea cycle)|go:"GO:0004087"("carbamoyl-phosphate synthase (ammonia) activity")|go:"GO:0004088"("carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity")|go:"GO:0004175"(endopeptidase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0006207"('de novo' pyrimidine nucleobase biosynthetic process)|go:"GO:0006541"(glutamine metabolic process)|go:"GO:0006807"(nitrogen compound metabolic process)|go:"GO:0007494"(midgut development)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010043"(response to zinc ion)|go:"GO:0014075"(response to amine)|go:"GO:0016595"(glutamate binding)|go:"GO:0019433"(triglyceride catabolic process)|go:"GO:0032094"(response to food)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042311"(vasodilation)|go:"GO:0042493"|go:"GO:0042594"(response to starvation)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0043200"(response to amino acid)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046209"(nitric oxide metabolic process)|go:"GO:0050667"(homocysteine metabolic process)|go:"GO:0055081"(anion homeostasis)|go:"GO:0060416"(response to growth hormone)|go:"GO:0070365"(hepatocyte differentiation)|go:"GO:0070409"(carbamoyl phosphate biosynthetic process)|go:"GO:0071242"(cellular response to ammonium ion)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071377"(cellular response to glucagon stimulus)|go:"GO:0071400"(cellular response to oleic acid)|go:"GO:0071548"(response to dexamethasone)|go:"GO:0072341"(modified amino acid binding)|interpro:IPR002474(Carbamoyl phosphate synthase, small subunit, N-terminal)|interpro:IPR005479(Carbamoyl phosphate synthetase, large subunit, ATP-binding)|interpro:IPR005480(Carbamoyl phosphate synthetase, large subunit, oligomerisation)|interpro:IPR005483(Carbamoyl phosphate synthase, large subunit)|interpro:IPR006274(Carbamoyl phosphate synthase, small subunit)|interpro:IPR006275(Carbamoyl phosphate synthase, large subunit, glutamine-dependent)|interpro:IPR011607(MGS-like)|interpro:IPR011761(ATP-grasp fold)|interpro:IPR013815(ATP-grasp fold, subdomain 1)|interpro:IPR016185(PreATP-grasp-like fold)|interpro:IPR017926|interpro:IPR029062|interpro:IPR035686|interpro:IPR036480|interpro:IPR036897|interpro:IPR036914|mint:Q8C196|reactome:R-MMU-70635	go:"GO:0005759"(mitochondrial matrix)	-	-	figure legend:Fig. 2D, 2E|comment:Interaction not observed in SIRT5 knockout cells.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-liver)|taxid:10090(Mus musculus)	-	2009/06/10	2014/10/16	rogid:PWG9j7k8N9X9cBJOfVnkLgYzH9E10090	rogid:rF6N6MgpvcLpTEy98xLg4/NqUCY10090	intact-crc:F31036B4CB1703F2|rigid:klMr3i9i+Hs/iP6i7tiYsJOrs9g	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)