#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:O75150	uniprotkb:Q5VTR2	intact:EBI-744408|uniprotkb:Q6AHZ6|uniprotkb:Q6N005|uniprotkb:Q7L3T6|uniprotkb:Q8N615|uniprotkb:Q96T18|uniprotkb:Q9BSV9|uniprotkb:Q9HC82|ensembl:ENSP00000325677|uniprotkb:A0A024QZG0	intact:EBI-2372238|uniprotkb:Q2TB34|uniprotkb:Q69YL5|uniprotkb:Q6P527|uniprotkb:Q8N3J4|uniprotkb:Q96JD3|uniprotkb:Q9H9Y7|uniprotkb:Q9HA51|uniprotkb:Q9NUR4|uniprotkb:Q9NWQ3|uniprotkb:Q9NX83|uniprotkb:A7MCT5|ensembl:ENSP00000373772	psi-mi:bre1b_human(display_long)|uniprotkb:95 kDa retinoblastoma-associated protein(gene name synonym)|uniprotkb:RING finger protein 40(gene name synonym)|uniprotkb:RNF40(gene name)|psi-mi:RNF40(display_short)|uniprotkb:BRE1B(gene name synonym)|uniprotkb:KIAA0661(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BRE1B(gene name synonym)	psi-mi:bre1a_human(display_long)|uniprotkb:RNF20(gene name)|psi-mi:RNF20(display_short)|uniprotkb:BRE1A(gene name synonym)|uniprotkb:RING finger protein 20(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BRE1A(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kim et al. (2009)	imex:IM-12178|pubmed:19410543	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2410785|imex:IM-12178-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001273501.1|refseq:NP_001193962.1|refseq:NP_001193963.1|refseq:NP_055586.1|go:"GO:1900364"(negative regulation of mRNA polyadenylation)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902916"(positive regulation of protein polyubiquitination)|go:"GO:2001168"(positive regulation of histone H2B ubiquitination)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013956(E3 ubiquitin ligase, BRE1)|interpro:IPR017907|mint:O75150|reactome:R-HSA-8866654|go:"GO:0046872"(metal ion binding)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043679"(axon terminus)|go:"GO:0044877"(protein-containing complex binding)|ensembl:ENSG00000103549(gene)|ensembl:ENST00000324685(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0016020"(membrane)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033503"(HULC complex)	refseq:XP_011517164.1|refseq:NP_062538.5|dip:DIP-53411N|ensembl:ENSG00000155827(gene)|ensembl:ENST00000389120(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002039"(p53 binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0031062"(positive regulation of histone methylation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033503"(HULC complex)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0042393"(histone binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:1900364"(negative regulation of mRNA polyadenylation)|go:"GO:2001168"(positive regulation of histone H2B ubiquitination)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013956(E3 ubiquitin ligase, BRE1)|interpro:IPR017907|mint:Q5VTR2|rcsb pdb:5TRB|reactome:R-HSA-8866654|reactome:R-HSA-9013422	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1A|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/06/01	2018/09/18	rogid:POkQZhEBe4cw3Y9V3YOwJDgvYJ89606	rogid:zscBhEtpu0D69sPn1wXsEGBIiOY9606	intact-crc:D1E65408E8ED882A|rigid:gq5a660ZKl+dvAJFWaW5PB01GdY	false	ha tag:?-?	flag tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O75150	uniprotkb:Q5VTR2	intact:EBI-744408|uniprotkb:Q6AHZ6|uniprotkb:Q6N005|uniprotkb:Q7L3T6|uniprotkb:Q8N615|uniprotkb:Q96T18|uniprotkb:Q9BSV9|uniprotkb:Q9HC82|ensembl:ENSP00000325677|uniprotkb:A0A024QZG0	intact:EBI-2372238|uniprotkb:Q2TB34|uniprotkb:Q69YL5|uniprotkb:Q6P527|uniprotkb:Q8N3J4|uniprotkb:Q96JD3|uniprotkb:Q9H9Y7|uniprotkb:Q9HA51|uniprotkb:Q9NUR4|uniprotkb:Q9NWQ3|uniprotkb:Q9NX83|uniprotkb:A7MCT5|ensembl:ENSP00000373772	psi-mi:bre1b_human(display_long)|uniprotkb:95 kDa retinoblastoma-associated protein(gene name synonym)|uniprotkb:RING finger protein 40(gene name synonym)|uniprotkb:RNF40(gene name)|psi-mi:RNF40(display_short)|uniprotkb:BRE1B(gene name synonym)|uniprotkb:KIAA0661(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BRE1B(gene name synonym)	psi-mi:bre1a_human(display_long)|uniprotkb:RNF20(gene name)|psi-mi:RNF20(display_short)|uniprotkb:BRE1A(gene name synonym)|uniprotkb:RING finger protein 20(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BRE1A(gene name synonym)	psi-mi:"MI:0091"(chromatography technology)	Kim et al. (2009)	imex:IM-12178|pubmed:19410543	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2410795|imex:IM-12178-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001273501.1|refseq:NP_001193962.1|refseq:NP_001193963.1|refseq:NP_055586.1|go:"GO:1900364"(negative regulation of mRNA polyadenylation)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902916"(positive regulation of protein polyubiquitination)|go:"GO:2001168"(positive regulation of histone H2B ubiquitination)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013956(E3 ubiquitin ligase, BRE1)|interpro:IPR017907|mint:O75150|reactome:R-HSA-8866654|go:"GO:0046872"(metal ion binding)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043679"(axon terminus)|go:"GO:0044877"(protein-containing complex binding)|ensembl:ENSG00000103549(gene)|ensembl:ENST00000324685(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0016020"(membrane)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033503"(HULC complex)	refseq:XP_011517164.1|refseq:NP_062538.5|dip:DIP-53411N|ensembl:ENSG00000155827(gene)|ensembl:ENST00000389120(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002039"(p53 binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0031062"(positive regulation of histone methylation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033503"(HULC complex)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0042393"(histone binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:1900364"(negative regulation of mRNA polyadenylation)|go:"GO:2001168"(positive regulation of histone H2B ubiquitination)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013956(E3 ubiquitin ligase, BRE1)|interpro:IPR017907|mint:Q5VTR2|rcsb pdb:5TRB|reactome:R-HSA-8866654|reactome:R-HSA-9013422	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7108(spofr-sf_9)|taxid:7108(Spodoptera frugiperda insect cells)	-	2009/06/01	2018/09/18	rogid:POkQZhEBe4cw3Y9V3YOwJDgvYJ89606	rogid:zscBhEtpu0D69sPn1wXsEGBIiOY9606	intact-crc:5EAA8984831816B1|rigid:gq5a660ZKl+dvAJFWaW5PB01GdY	false	flag tag:?-?	-	1	1	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O75150	uniprotkb:Q5VTR2	intact:EBI-744408|uniprotkb:Q6AHZ6|uniprotkb:Q6N005|uniprotkb:Q7L3T6|uniprotkb:Q8N615|uniprotkb:Q96T18|uniprotkb:Q9BSV9|uniprotkb:Q9HC82|ensembl:ENSP00000325677|uniprotkb:A0A024QZG0	intact:EBI-2372238|uniprotkb:Q2TB34|uniprotkb:Q69YL5|uniprotkb:Q6P527|uniprotkb:Q8N3J4|uniprotkb:Q96JD3|uniprotkb:Q9H9Y7|uniprotkb:Q9HA51|uniprotkb:Q9NUR4|uniprotkb:Q9NWQ3|uniprotkb:Q9NX83|uniprotkb:A7MCT5|ensembl:ENSP00000373772	psi-mi:bre1b_human(display_long)|uniprotkb:95 kDa retinoblastoma-associated protein(gene name synonym)|uniprotkb:RING finger protein 40(gene name synonym)|uniprotkb:RNF40(gene name)|psi-mi:RNF40(display_short)|uniprotkb:BRE1B(gene name synonym)|uniprotkb:KIAA0661(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BRE1B(gene name synonym)	psi-mi:bre1a_human(display_long)|uniprotkb:RNF20(gene name)|psi-mi:RNF20(display_short)|uniprotkb:BRE1A(gene name synonym)|uniprotkb:RING finger protein 20(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BRE1A(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kim et al. (2009)	imex:IM-12178|pubmed:19410543	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2410803|imex:IM-12178-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001273501.1|refseq:NP_001193962.1|refseq:NP_001193963.1|refseq:NP_055586.1|go:"GO:1900364"(negative regulation of mRNA polyadenylation)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902916"(positive regulation of protein polyubiquitination)|go:"GO:2001168"(positive regulation of histone H2B ubiquitination)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013956(E3 ubiquitin ligase, BRE1)|interpro:IPR017907|mint:O75150|reactome:R-HSA-8866654|go:"GO:0046872"(metal ion binding)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043679"(axon terminus)|go:"GO:0044877"(protein-containing complex binding)|ensembl:ENSG00000103549(gene)|ensembl:ENST00000324685(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0016020"(membrane)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033503"(HULC complex)	refseq:XP_011517164.1|refseq:NP_062538.5|dip:DIP-53411N|ensembl:ENSG00000155827(gene)|ensembl:ENST00000389120(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002039"(p53 binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0031062"(positive regulation of histone methylation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033503"(HULC complex)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0042393"(histone binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:1900364"(negative regulation of mRNA polyadenylation)|go:"GO:2001168"(positive regulation of histone H2B ubiquitination)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013956(E3 ubiquitin ligase, BRE1)|interpro:IPR017907|mint:Q5VTR2|rcsb pdb:5TRB|reactome:R-HSA-8866654|reactome:R-HSA-9013422	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1C|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7108(spofr-sf_9)|taxid:7108(Spodoptera frugiperda insect cells)	-	2009/06/01	2018/09/18	rogid:POkQZhEBe4cw3Y9V3YOwJDgvYJ89606	rogid:zscBhEtpu0D69sPn1wXsEGBIiOY9606	intact-crc:FDDD2A376A5C1119|rigid:gq5a660ZKl+dvAJFWaW5PB01GdY	false	-	flag tag:?-?|necessary binding region:1-381	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P49459	uniprotkb:Q5VTR2	intact:EBI-2339348|uniprotkb:A6NMF5|uniprotkb:Q96FX4|uniprotkb:B2R7R9|uniprotkb:Q4TTG1|uniprotkb:D3DWI1|uniprotkb:A6NFE9|uniprotkb:A6NGR2|ensembl:ENSP00000360613	intact:EBI-2372238|uniprotkb:Q2TB34|uniprotkb:Q69YL5|uniprotkb:Q6P527|uniprotkb:Q8N3J4|uniprotkb:Q96JD3|uniprotkb:Q9H9Y7|uniprotkb:Q9HA51|uniprotkb:Q9NUR4|uniprotkb:Q9NWQ3|uniprotkb:Q9NX83|uniprotkb:A7MCT5|ensembl:ENSP00000373772	psi-mi:ube2a_human(display_long)|uniprotkb:UBE2A(gene name)|psi-mi:UBE2A(display_short)|uniprotkb:RAD6A(gene name synonym)|uniprotkb:Ubiquitin-protein ligase A(gene name synonym)|uniprotkb:Ubiquitin carrier protein A(gene name synonym)|uniprotkb:RAD6 homolog A(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme A(gene name synonym)	psi-mi:bre1a_human(display_long)|uniprotkb:RNF20(gene name)|psi-mi:RNF20(display_short)|uniprotkb:BRE1A(gene name synonym)|uniprotkb:RING finger protein 20(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BRE1A(gene name synonym)	psi-mi:"MI:0096"(pull down)	Kim et al. (2009)	imex:IM-12178|pubmed:19410543	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2410813|imex:IM-12178-10	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003327.2|refseq:NP_861427.1|refseq:NP_001269090.1|dip:DIP-24260N|ensembl:ENSG00000077721(gene)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000785"(chromatin)|go:"GO:0001741"(XY body)|go:"GO:0001835"(blastocyst hatching)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009411"(response to UV)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033503"(HULC complex)|go:"GO:0033522"(histone H2A ubiquitination)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0060135"(maternal process involved in female pregnancy)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0070979"(protein K11-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|mint:P49459|rcsb pdb:6CYO|rcsb pdb:6CYR|reactome:R-HSA-8866652|reactome:R-HSA-8866654|reactome:R-HSA-983168|ensembl:ENST00000371558(transcript)	refseq:XP_011517164.1|refseq:NP_062538.5|dip:DIP-53411N|ensembl:ENSG00000155827(gene)|ensembl:ENST00000389120(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002039"(p53 binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0031062"(positive regulation of histone methylation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033503"(HULC complex)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0042393"(histone binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:1900364"(negative regulation of mRNA polyadenylation)|go:"GO:2001168"(positive regulation of histone H2B ubiquitination)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013956(E3 ubiquitin ligase, BRE1)|interpro:IPR017907|mint:Q5VTR2|rcsb pdb:5TRB|reactome:R-HSA-8866654|reactome:R-HSA-9013422	psi-mi:"MI:0469"(intact)	-	-	figure legend:Figs. 3B, 3G and Supp. Fig. 2B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/06/01	2018/09/18	rogid:T6Mzgy6RHO9HoEIG3FmQvsP32vU9606	rogid:zscBhEtpu0D69sPn1wXsEGBIiOY9606	intact-crc:0FD3756414B4BAA4|rigid:O2+XsQ3XDmrw2mKfYtBr1vVc1fw	false	glutathione s tranferase tag:?-?	flag tag:?-?|necessary binding region:1-381	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P49459	uniprotkb:O75150	intact:EBI-2339348|uniprotkb:A6NMF5|uniprotkb:Q96FX4|uniprotkb:B2R7R9|uniprotkb:Q4TTG1|uniprotkb:D3DWI1|uniprotkb:A6NFE9|uniprotkb:A6NGR2|ensembl:ENSP00000360613	intact:EBI-744408|uniprotkb:Q6AHZ6|uniprotkb:Q6N005|uniprotkb:Q7L3T6|uniprotkb:Q8N615|uniprotkb:Q96T18|uniprotkb:Q9BSV9|uniprotkb:Q9HC82|ensembl:ENSP00000325677|uniprotkb:A0A024QZG0	psi-mi:ube2a_human(display_long)|uniprotkb:UBE2A(gene name)|psi-mi:UBE2A(display_short)|uniprotkb:RAD6A(gene name synonym)|uniprotkb:Ubiquitin-protein ligase A(gene name synonym)|uniprotkb:Ubiquitin carrier protein A(gene name synonym)|uniprotkb:RAD6 homolog A(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme A(gene name synonym)	psi-mi:bre1b_human(display_long)|uniprotkb:95 kDa retinoblastoma-associated protein(gene name synonym)|uniprotkb:RING finger protein 40(gene name synonym)|uniprotkb:RNF40(gene name)|psi-mi:RNF40(display_short)|uniprotkb:BRE1B(gene name synonym)|uniprotkb:KIAA0661(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BRE1B(gene name synonym)	psi-mi:"MI:0096"(pull down)	Kim et al. (2009)	imex:IM-12178|pubmed:19410543	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2410813|imex:IM-12178-10	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003327.2|refseq:NP_861427.1|refseq:NP_001269090.1|dip:DIP-24260N|ensembl:ENSG00000077721(gene)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000785"(chromatin)|go:"GO:0001741"(XY body)|go:"GO:0001835"(blastocyst hatching)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009411"(response to UV)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033503"(HULC complex)|go:"GO:0033522"(histone H2A ubiquitination)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0060135"(maternal process involved in female pregnancy)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0070979"(protein K11-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|mint:P49459|rcsb pdb:6CYO|rcsb pdb:6CYR|reactome:R-HSA-8866652|reactome:R-HSA-8866654|reactome:R-HSA-983168|ensembl:ENST00000371558(transcript)	refseq:NP_001273501.1|refseq:NP_001193962.1|refseq:NP_001193963.1|refseq:NP_055586.1|go:"GO:1900364"(negative regulation of mRNA polyadenylation)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902916"(positive regulation of protein polyubiquitination)|go:"GO:2001168"(positive regulation of histone H2B ubiquitination)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013956(E3 ubiquitin ligase, BRE1)|interpro:IPR017907|mint:O75150|reactome:R-HSA-8866654|go:"GO:0046872"(metal ion binding)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043679"(axon terminus)|go:"GO:0044877"(protein-containing complex binding)|ensembl:ENSG00000103549(gene)|ensembl:ENST00000324685(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0016020"(membrane)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033503"(HULC complex)	psi-mi:"MI:0469"(intact)	-	-	figure legend:Figs. 3B, 3G and Supp. Fig. 2B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/06/01	2018/09/18	rogid:T6Mzgy6RHO9HoEIG3FmQvsP32vU9606	rogid:POkQZhEBe4cw3Y9V3YOwJDgvYJ89606	intact-crc:0FD3756414B4BAA4|rigid:O2+XsQ3XDmrw2mKfYtBr1vVc1fw	false	glutathione s tranferase tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P63146	uniprotkb:O75150	intact:EBI-712629|uniprotkb:P23567|uniprotkb:Q4PJ15|ensembl:ENSP00000265339|uniprotkb:Q9D0J6|uniprotkb:B2R503|uniprotkb:D3DQA2	intact:EBI-744408|uniprotkb:Q6AHZ6|uniprotkb:Q6N005|uniprotkb:Q7L3T6|uniprotkb:Q8N615|uniprotkb:Q96T18|uniprotkb:Q9BSV9|uniprotkb:Q9HC82|ensembl:ENSP00000325677|uniprotkb:A0A024QZG0	psi-mi:ube2b_human(display_long)|uniprotkb:Ubiquitin-protein ligase B(gene name synonym)|uniprotkb:Ubiquitin carrier protein B(gene name synonym)|uniprotkb:RAD6 homolog B(gene name synonym)|uniprotkb:Ubiquitin-conjugating enzyme E2-17 kDa(gene name synonym)|uniprotkb:UBE2B(gene name)|psi-mi:UBE2B(display_short)|uniprotkb:RAD6B(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme B(gene name synonym)	psi-mi:bre1b_human(display_long)|uniprotkb:95 kDa retinoblastoma-associated protein(gene name synonym)|uniprotkb:RING finger protein 40(gene name synonym)|uniprotkb:RNF40(gene name)|psi-mi:RNF40(display_short)|uniprotkb:BRE1B(gene name synonym)|uniprotkb:KIAA0661(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BRE1B(gene name synonym)	psi-mi:"MI:0096"(pull down)	Kim et al. (2009)	imex:IM-12178|pubmed:19410543	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2410821|imex:IM-12178-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000119048(gene)|ensembl:ENST00000265339(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000785"(chromatin)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001741"(XY body)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006281"(DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007288"(sperm axoneme assembly)|go:"GO:0009411"(response to UV)|go:"GO:0010845"(positive regulation of reciprocal meiotic recombination)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|interpro:IPR023313|mint:P63146|rcsb pdb:1JAS|rcsb pdb:1NXA|rcsb pdb:2Y4W|rcsb pdb:2YB6|rcsb pdb:2YBF|reactome:R-HSA-110314|reactome:R-HSA-8866652|reactome:R-HSA-8866654|reactome:R-HSA-983168|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033128"(negative regulation of histone phosphorylation)|go:"GO:0033503"(HULC complex)|go:"GO:0033522"(histone H2A ubiquitination)|go:"GO:0042493"|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043951"(negative regulation of cAMP-mediated signaling)|go:"GO:0045141"(meiotic telomere clustering)|go:"GO:0050821"(protein stabilization)|go:"GO:0051026"(chiasma assembly)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070076"(histone lysine demethylation)|go:"GO:0070193"(synaptonemal complex organization)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070829"(obsolete heterochromatin maintenance)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0070979"(protein K11-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|refseq:NP_003328.1|dip:DIP-29832N	refseq:NP_001273501.1|refseq:NP_001193962.1|refseq:NP_001193963.1|refseq:NP_055586.1|go:"GO:1900364"(negative regulation of mRNA polyadenylation)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902916"(positive regulation of protein polyubiquitination)|go:"GO:2001168"(positive regulation of histone H2B ubiquitination)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013956(E3 ubiquitin ligase, BRE1)|interpro:IPR017907|mint:O75150|reactome:R-HSA-8866654|go:"GO:0046872"(metal ion binding)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043679"(axon terminus)|go:"GO:0044877"(protein-containing complex binding)|ensembl:ENSG00000103549(gene)|ensembl:ENST00000324685(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0016020"(membrane)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033503"(HULC complex)	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 3 and Supp. Fig. 2B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/06/01	2018/09/18	rogid:JvcUPH+3qQXicPsIRFnW19NOc3c9606	rogid:POkQZhEBe4cw3Y9V3YOwJDgvYJ89606	intact-crc:100D4FD65CE923DF|rigid:L01qGlecsWuoSitQEy0cYZ7R+mA	false	glutathione s tranferase tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P63146	uniprotkb:Q5VTR2	intact:EBI-712629|uniprotkb:P23567|uniprotkb:Q4PJ15|ensembl:ENSP00000265339|uniprotkb:Q9D0J6|uniprotkb:B2R503|uniprotkb:D3DQA2	intact:EBI-2372238|uniprotkb:Q2TB34|uniprotkb:Q69YL5|uniprotkb:Q6P527|uniprotkb:Q8N3J4|uniprotkb:Q96JD3|uniprotkb:Q9H9Y7|uniprotkb:Q9HA51|uniprotkb:Q9NUR4|uniprotkb:Q9NWQ3|uniprotkb:Q9NX83|uniprotkb:A7MCT5|ensembl:ENSP00000373772	psi-mi:ube2b_human(display_long)|uniprotkb:Ubiquitin-protein ligase B(gene name synonym)|uniprotkb:Ubiquitin carrier protein B(gene name synonym)|uniprotkb:RAD6 homolog B(gene name synonym)|uniprotkb:Ubiquitin-conjugating enzyme E2-17 kDa(gene name synonym)|uniprotkb:UBE2B(gene name)|psi-mi:UBE2B(display_short)|uniprotkb:RAD6B(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme B(gene name synonym)	psi-mi:bre1a_human(display_long)|uniprotkb:RNF20(gene name)|psi-mi:RNF20(display_short)|uniprotkb:BRE1A(gene name synonym)|uniprotkb:RING finger protein 20(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BRE1A(gene name synonym)	psi-mi:"MI:0096"(pull down)	Kim et al. (2009)	imex:IM-12178|pubmed:19410543	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2410821|imex:IM-12178-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000119048(gene)|ensembl:ENST00000265339(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000785"(chromatin)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001741"(XY body)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006281"(DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007288"(sperm axoneme assembly)|go:"GO:0009411"(response to UV)|go:"GO:0010845"(positive regulation of reciprocal meiotic recombination)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|interpro:IPR023313|mint:P63146|rcsb pdb:1JAS|rcsb pdb:1NXA|rcsb pdb:2Y4W|rcsb pdb:2YB6|rcsb pdb:2YBF|reactome:R-HSA-110314|reactome:R-HSA-8866652|reactome:R-HSA-8866654|reactome:R-HSA-983168|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033128"(negative regulation of histone phosphorylation)|go:"GO:0033503"(HULC complex)|go:"GO:0033522"(histone H2A ubiquitination)|go:"GO:0042493"|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043951"(negative regulation of cAMP-mediated signaling)|go:"GO:0045141"(meiotic telomere clustering)|go:"GO:0050821"(protein stabilization)|go:"GO:0051026"(chiasma assembly)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070076"(histone lysine demethylation)|go:"GO:0070193"(synaptonemal complex organization)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070829"(obsolete heterochromatin maintenance)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0070979"(protein K11-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|refseq:NP_003328.1|dip:DIP-29832N	refseq:XP_011517164.1|refseq:NP_062538.5|dip:DIP-53411N|ensembl:ENSG00000155827(gene)|ensembl:ENST00000389120(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002039"(p53 binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0031062"(positive regulation of histone methylation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033503"(HULC complex)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0042393"(histone binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:1900364"(negative regulation of mRNA polyadenylation)|go:"GO:2001168"(positive regulation of histone H2B ubiquitination)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013956(E3 ubiquitin ligase, BRE1)|interpro:IPR017907|mint:Q5VTR2|rcsb pdb:5TRB|reactome:R-HSA-8866654|reactome:R-HSA-9013422	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 3 and Supp. Fig. 2B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/06/01	2018/09/18	rogid:JvcUPH+3qQXicPsIRFnW19NOc3c9606	rogid:zscBhEtpu0D69sPn1wXsEGBIiOY9606	intact-crc:100D4FD65CE923DF|rigid:L01qGlecsWuoSitQEy0cYZ7R+mA	false	glutathione s tranferase tag:?-?	flag tag:?-?|necessary binding region:1-381	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P49459	uniprotkb:O75150	intact:EBI-2339348|uniprotkb:A6NMF5|uniprotkb:Q96FX4|uniprotkb:B2R7R9|uniprotkb:Q4TTG1|uniprotkb:D3DWI1|uniprotkb:A6NFE9|uniprotkb:A6NGR2|ensembl:ENSP00000360613	intact:EBI-744408|uniprotkb:Q6AHZ6|uniprotkb:Q6N005|uniprotkb:Q7L3T6|uniprotkb:Q8N615|uniprotkb:Q96T18|uniprotkb:Q9BSV9|uniprotkb:Q9HC82|ensembl:ENSP00000325677|uniprotkb:A0A024QZG0	psi-mi:ube2a_human(display_long)|uniprotkb:UBE2A(gene name)|psi-mi:UBE2A(display_short)|uniprotkb:RAD6A(gene name synonym)|uniprotkb:Ubiquitin-protein ligase A(gene name synonym)|uniprotkb:Ubiquitin carrier protein A(gene name synonym)|uniprotkb:RAD6 homolog A(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme A(gene name synonym)	psi-mi:bre1b_human(display_long)|uniprotkb:95 kDa retinoblastoma-associated protein(gene name synonym)|uniprotkb:RING finger protein 40(gene name synonym)|uniprotkb:RNF40(gene name)|psi-mi:RNF40(display_short)|uniprotkb:BRE1B(gene name synonym)|uniprotkb:KIAA0661(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BRE1B(gene name synonym)	psi-mi:"MI:0096"(pull down)	Kim et al. (2009)	imex:IM-12178|pubmed:19410543	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2410833|imex:IM-12178-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003327.2|refseq:NP_861427.1|refseq:NP_001269090.1|dip:DIP-24260N|ensembl:ENSG00000077721(gene)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000785"(chromatin)|go:"GO:0001741"(XY body)|go:"GO:0001835"(blastocyst hatching)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009411"(response to UV)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033503"(HULC complex)|go:"GO:0033522"(histone H2A ubiquitination)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0060135"(maternal process involved in female pregnancy)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0070979"(protein K11-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|mint:P49459|rcsb pdb:6CYO|rcsb pdb:6CYR|reactome:R-HSA-8866652|reactome:R-HSA-8866654|reactome:R-HSA-983168|ensembl:ENST00000371558(transcript)	refseq:NP_001273501.1|refseq:NP_001193962.1|refseq:NP_001193963.1|refseq:NP_055586.1|go:"GO:1900364"(negative regulation of mRNA polyadenylation)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902916"(positive regulation of protein polyubiquitination)|go:"GO:2001168"(positive regulation of histone H2B ubiquitination)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013956(E3 ubiquitin ligase, BRE1)|interpro:IPR017907|mint:O75150|reactome:R-HSA-8866654|go:"GO:0046872"(metal ion binding)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043679"(axon terminus)|go:"GO:0044877"(protein-containing complex binding)|ensembl:ENSG00000103549(gene)|ensembl:ENST00000324685(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0016020"(membrane)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033503"(HULC complex)	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supp. Fig. 4|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/06/01	2018/09/18	rogid:T6Mzgy6RHO9HoEIG3FmQvsP32vU9606	rogid:POkQZhEBe4cw3Y9V3YOwJDgvYJ89606	intact-crc:5C203E316C5909BB|rigid:O2+XsQ3XDmrw2mKfYtBr1vVc1fw	false	his tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P49459	uniprotkb:Q5VTR2	intact:EBI-2339348|uniprotkb:A6NMF5|uniprotkb:Q96FX4|uniprotkb:B2R7R9|uniprotkb:Q4TTG1|uniprotkb:D3DWI1|uniprotkb:A6NFE9|uniprotkb:A6NGR2|ensembl:ENSP00000360613	intact:EBI-2372238|uniprotkb:Q2TB34|uniprotkb:Q69YL5|uniprotkb:Q6P527|uniprotkb:Q8N3J4|uniprotkb:Q96JD3|uniprotkb:Q9H9Y7|uniprotkb:Q9HA51|uniprotkb:Q9NUR4|uniprotkb:Q9NWQ3|uniprotkb:Q9NX83|uniprotkb:A7MCT5|ensembl:ENSP00000373772	psi-mi:ube2a_human(display_long)|uniprotkb:UBE2A(gene name)|psi-mi:UBE2A(display_short)|uniprotkb:RAD6A(gene name synonym)|uniprotkb:Ubiquitin-protein ligase A(gene name synonym)|uniprotkb:Ubiquitin carrier protein A(gene name synonym)|uniprotkb:RAD6 homolog A(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme A(gene name synonym)	psi-mi:bre1a_human(display_long)|uniprotkb:RNF20(gene name)|psi-mi:RNF20(display_short)|uniprotkb:BRE1A(gene name synonym)|uniprotkb:RING finger protein 20(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BRE1A(gene name synonym)	psi-mi:"MI:0096"(pull down)	Kim et al. (2009)	imex:IM-12178|pubmed:19410543	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2410833|imex:IM-12178-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003327.2|refseq:NP_861427.1|refseq:NP_001269090.1|dip:DIP-24260N|ensembl:ENSG00000077721(gene)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000785"(chromatin)|go:"GO:0001741"(XY body)|go:"GO:0001835"(blastocyst hatching)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009411"(response to UV)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033503"(HULC complex)|go:"GO:0033522"(histone H2A ubiquitination)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0060135"(maternal process involved in female pregnancy)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0070979"(protein K11-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|mint:P49459|rcsb pdb:6CYO|rcsb pdb:6CYR|reactome:R-HSA-8866652|reactome:R-HSA-8866654|reactome:R-HSA-983168|ensembl:ENST00000371558(transcript)	refseq:XP_011517164.1|refseq:NP_062538.5|dip:DIP-53411N|ensembl:ENSG00000155827(gene)|ensembl:ENST00000389120(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002039"(p53 binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0031062"(positive regulation of histone methylation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033503"(HULC complex)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0042393"(histone binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:1900364"(negative regulation of mRNA polyadenylation)|go:"GO:2001168"(positive regulation of histone H2B ubiquitination)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013956(E3 ubiquitin ligase, BRE1)|interpro:IPR017907|mint:Q5VTR2|rcsb pdb:5TRB|reactome:R-HSA-8866654|reactome:R-HSA-9013422	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supp. Fig. 4|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/06/01	2018/09/18	rogid:T6Mzgy6RHO9HoEIG3FmQvsP32vU9606	rogid:zscBhEtpu0D69sPn1wXsEGBIiOY9606	intact-crc:5C203E316C5909BB|rigid:O2+XsQ3XDmrw2mKfYtBr1vVc1fw	false	his tag:?-?	flag tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P63146	uniprotkb:Q5VTR2	intact:EBI-712629|uniprotkb:P23567|uniprotkb:Q4PJ15|ensembl:ENSP00000265339|uniprotkb:Q9D0J6|uniprotkb:B2R503|uniprotkb:D3DQA2	intact:EBI-2372238|uniprotkb:Q2TB34|uniprotkb:Q69YL5|uniprotkb:Q6P527|uniprotkb:Q8N3J4|uniprotkb:Q96JD3|uniprotkb:Q9H9Y7|uniprotkb:Q9HA51|uniprotkb:Q9NUR4|uniprotkb:Q9NWQ3|uniprotkb:Q9NX83|uniprotkb:A7MCT5|ensembl:ENSP00000373772	psi-mi:ube2b_human(display_long)|uniprotkb:Ubiquitin-protein ligase B(gene name synonym)|uniprotkb:Ubiquitin carrier protein B(gene name synonym)|uniprotkb:RAD6 homolog B(gene name synonym)|uniprotkb:Ubiquitin-conjugating enzyme E2-17 kDa(gene name synonym)|uniprotkb:UBE2B(gene name)|psi-mi:UBE2B(display_short)|uniprotkb:RAD6B(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme B(gene name synonym)	psi-mi:bre1a_human(display_long)|uniprotkb:RNF20(gene name)|psi-mi:RNF20(display_short)|uniprotkb:BRE1A(gene name synonym)|uniprotkb:RING finger protein 20(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BRE1A(gene name synonym)	psi-mi:"MI:0096"(pull down)	Kim et al. (2009)	imex:IM-12178|pubmed:19410543	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2410843|imex:IM-12178-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000119048(gene)|ensembl:ENST00000265339(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000785"(chromatin)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001741"(XY body)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006281"(DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007288"(sperm axoneme assembly)|go:"GO:0009411"(response to UV)|go:"GO:0010845"(positive regulation of reciprocal meiotic recombination)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|interpro:IPR023313|mint:P63146|rcsb pdb:1JAS|rcsb pdb:1NXA|rcsb pdb:2Y4W|rcsb pdb:2YB6|rcsb pdb:2YBF|reactome:R-HSA-110314|reactome:R-HSA-8866652|reactome:R-HSA-8866654|reactome:R-HSA-983168|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033128"(negative regulation of histone phosphorylation)|go:"GO:0033503"(HULC complex)|go:"GO:0033522"(histone H2A ubiquitination)|go:"GO:0042493"|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043951"(negative regulation of cAMP-mediated signaling)|go:"GO:0045141"(meiotic telomere clustering)|go:"GO:0050821"(protein stabilization)|go:"GO:0051026"(chiasma assembly)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070076"(histone lysine demethylation)|go:"GO:0070193"(synaptonemal complex organization)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070829"(obsolete heterochromatin maintenance)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0070979"(protein K11-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|refseq:NP_003328.1|dip:DIP-29832N	refseq:XP_011517164.1|refseq:NP_062538.5|dip:DIP-53411N|ensembl:ENSG00000155827(gene)|ensembl:ENST00000389120(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002039"(p53 binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0031062"(positive regulation of histone methylation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033503"(HULC complex)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0042393"(histone binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:1900364"(negative regulation of mRNA polyadenylation)|go:"GO:2001168"(positive regulation of histone H2B ubiquitination)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013956(E3 ubiquitin ligase, BRE1)|interpro:IPR017907|mint:Q5VTR2|rcsb pdb:5TRB|reactome:R-HSA-8866654|reactome:R-HSA-9013422	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supp. Fig. 3|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/06/01	2018/09/18	rogid:JvcUPH+3qQXicPsIRFnW19NOc3c9606	rogid:zscBhEtpu0D69sPn1wXsEGBIiOY9606	intact-crc:E9B8C7C15359599C|rigid:L01qGlecsWuoSitQEy0cYZ7R+mA	false	his tag:?-?	flag tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P63146	uniprotkb:O75150	intact:EBI-712629|uniprotkb:P23567|uniprotkb:Q4PJ15|ensembl:ENSP00000265339|uniprotkb:Q9D0J6|uniprotkb:B2R503|uniprotkb:D3DQA2	intact:EBI-744408|uniprotkb:Q6AHZ6|uniprotkb:Q6N005|uniprotkb:Q7L3T6|uniprotkb:Q8N615|uniprotkb:Q96T18|uniprotkb:Q9BSV9|uniprotkb:Q9HC82|ensembl:ENSP00000325677|uniprotkb:A0A024QZG0	psi-mi:ube2b_human(display_long)|uniprotkb:Ubiquitin-protein ligase B(gene name synonym)|uniprotkb:Ubiquitin carrier protein B(gene name synonym)|uniprotkb:RAD6 homolog B(gene name synonym)|uniprotkb:Ubiquitin-conjugating enzyme E2-17 kDa(gene name synonym)|uniprotkb:UBE2B(gene name)|psi-mi:UBE2B(display_short)|uniprotkb:RAD6B(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme B(gene name synonym)	psi-mi:bre1b_human(display_long)|uniprotkb:95 kDa retinoblastoma-associated protein(gene name synonym)|uniprotkb:RING finger protein 40(gene name synonym)|uniprotkb:RNF40(gene name)|psi-mi:RNF40(display_short)|uniprotkb:BRE1B(gene name synonym)|uniprotkb:KIAA0661(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BRE1B(gene name synonym)	psi-mi:"MI:0096"(pull down)	Kim et al. (2009)	imex:IM-12178|pubmed:19410543	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2410843|imex:IM-12178-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000119048(gene)|ensembl:ENST00000265339(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000785"(chromatin)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001741"(XY body)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006281"(DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007288"(sperm axoneme assembly)|go:"GO:0009411"(response to UV)|go:"GO:0010845"(positive regulation of reciprocal meiotic recombination)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|interpro:IPR023313|mint:P63146|rcsb pdb:1JAS|rcsb pdb:1NXA|rcsb pdb:2Y4W|rcsb pdb:2YB6|rcsb pdb:2YBF|reactome:R-HSA-110314|reactome:R-HSA-8866652|reactome:R-HSA-8866654|reactome:R-HSA-983168|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033128"(negative regulation of histone phosphorylation)|go:"GO:0033503"(HULC complex)|go:"GO:0033522"(histone H2A ubiquitination)|go:"GO:0042493"|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043951"(negative regulation of cAMP-mediated signaling)|go:"GO:0045141"(meiotic telomere clustering)|go:"GO:0050821"(protein stabilization)|go:"GO:0051026"(chiasma assembly)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070076"(histone lysine demethylation)|go:"GO:0070193"(synaptonemal complex organization)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070829"(obsolete heterochromatin maintenance)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0070979"(protein K11-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|refseq:NP_003328.1|dip:DIP-29832N	refseq:NP_001273501.1|refseq:NP_001193962.1|refseq:NP_001193963.1|refseq:NP_055586.1|go:"GO:1900364"(negative regulation of mRNA polyadenylation)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902916"(positive regulation of protein polyubiquitination)|go:"GO:2001168"(positive regulation of histone H2B ubiquitination)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013956(E3 ubiquitin ligase, BRE1)|interpro:IPR017907|mint:O75150|reactome:R-HSA-8866654|go:"GO:0046872"(metal ion binding)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043679"(axon terminus)|go:"GO:0044877"(protein-containing complex binding)|ensembl:ENSG00000103549(gene)|ensembl:ENST00000324685(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0016020"(membrane)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033503"(HULC complex)	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supp. Fig. 3|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/06/01	2018/09/18	rogid:JvcUPH+3qQXicPsIRFnW19NOc3c9606	rogid:POkQZhEBe4cw3Y9V3YOwJDgvYJ89606	intact-crc:E9B8C7C15359599C|rigid:L01qGlecsWuoSitQEy0cYZ7R+mA	false	his tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P49459	uniprotkb:Q5VTR2	intact:EBI-2339348|uniprotkb:A6NMF5|uniprotkb:Q96FX4|uniprotkb:B2R7R9|uniprotkb:Q4TTG1|uniprotkb:D3DWI1|uniprotkb:A6NFE9|uniprotkb:A6NGR2|ensembl:ENSP00000360613	intact:EBI-2372238|uniprotkb:Q2TB34|uniprotkb:Q69YL5|uniprotkb:Q6P527|uniprotkb:Q8N3J4|uniprotkb:Q96JD3|uniprotkb:Q9H9Y7|uniprotkb:Q9HA51|uniprotkb:Q9NUR4|uniprotkb:Q9NWQ3|uniprotkb:Q9NX83|uniprotkb:A7MCT5|ensembl:ENSP00000373772	psi-mi:ube2a_human(display_long)|uniprotkb:UBE2A(gene name)|psi-mi:UBE2A(display_short)|uniprotkb:RAD6A(gene name synonym)|uniprotkb:Ubiquitin-protein ligase A(gene name synonym)|uniprotkb:Ubiquitin carrier protein A(gene name synonym)|uniprotkb:RAD6 homolog A(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme A(gene name synonym)	psi-mi:bre1a_human(display_long)|uniprotkb:RNF20(gene name)|psi-mi:RNF20(display_short)|uniprotkb:BRE1A(gene name synonym)|uniprotkb:RING finger protein 20(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BRE1A(gene name synonym)	psi-mi:"MI:0096"(pull down)	Kim et al. (2009)	imex:IM-12178|pubmed:19410543	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2411060|imex:IM-12178-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003327.2|refseq:NP_861427.1|refseq:NP_001269090.1|dip:DIP-24260N|ensembl:ENSG00000077721(gene)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000785"(chromatin)|go:"GO:0001741"(XY body)|go:"GO:0001835"(blastocyst hatching)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009411"(response to UV)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033503"(HULC complex)|go:"GO:0033522"(histone H2A ubiquitination)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0060135"(maternal process involved in female pregnancy)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0070979"(protein K11-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|mint:P49459|rcsb pdb:6CYO|rcsb pdb:6CYR|reactome:R-HSA-8866652|reactome:R-HSA-8866654|reactome:R-HSA-983168|ensembl:ENST00000371558(transcript)	refseq:XP_011517164.1|refseq:NP_062538.5|dip:DIP-53411N|ensembl:ENSG00000155827(gene)|ensembl:ENST00000389120(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002039"(p53 binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0031062"(positive regulation of histone methylation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033503"(HULC complex)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0042393"(histone binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:1900364"(negative regulation of mRNA polyadenylation)|go:"GO:2001168"(positive regulation of histone H2B ubiquitination)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013956(E3 ubiquitin ligase, BRE1)|interpro:IPR017907|mint:Q5VTR2|rcsb pdb:5TRB|reactome:R-HSA-8866654|reactome:R-HSA-9013422	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 5B|comment:Interaction with PAF1 complex only occurs in the presence of the BRE1 complex.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/06/01	2018/09/18	rogid:T6Mzgy6RHO9HoEIG3FmQvsP32vU9606	rogid:zscBhEtpu0D69sPn1wXsEGBIiOY9606	intact-crc:F2F5053E5CA7161A|rigid:2Bx6WYJcajBgM55XnEoEwY0hKZs	false	glutathione s tranferase tag:?-?	his tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P49459	uniprotkb:Q92541	intact:EBI-2339348|uniprotkb:A6NMF5|uniprotkb:Q96FX4|uniprotkb:B2R7R9|uniprotkb:Q4TTG1|uniprotkb:D3DWI1|uniprotkb:A6NFE9|uniprotkb:A6NGR2|ensembl:ENSP00000360613	intact:EBI-1055239|uniprotkb:Q96BX6|ensembl:ENSP00000374280	psi-mi:ube2a_human(display_long)|uniprotkb:UBE2A(gene name)|psi-mi:UBE2A(display_short)|uniprotkb:RAD6A(gene name synonym)|uniprotkb:Ubiquitin-protein ligase A(gene name synonym)|uniprotkb:Ubiquitin carrier protein A(gene name synonym)|uniprotkb:RAD6 homolog A(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme A(gene name synonym)	psi-mi:rtf1_human(display_long)|uniprotkb:RTF1(gene name)|psi-mi:RTF1(display_short)|uniprotkb:KIAA0252(gene name synonym)	psi-mi:"MI:0096"(pull down)	Kim et al. (2009)	imex:IM-12178|pubmed:19410543	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2411060|imex:IM-12178-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003327.2|refseq:NP_861427.1|refseq:NP_001269090.1|dip:DIP-24260N|ensembl:ENSG00000077721(gene)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000785"(chromatin)|go:"GO:0001741"(XY body)|go:"GO:0001835"(blastocyst hatching)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009411"(response to UV)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033503"(HULC complex)|go:"GO:0033522"(histone H2A ubiquitination)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0060135"(maternal process involved in female pregnancy)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0070979"(protein K11-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|mint:P49459|rcsb pdb:6CYO|rcsb pdb:6CYR|reactome:R-HSA-8866652|reactome:R-HSA-8866654|reactome:R-HSA-983168|ensembl:ENST00000371558(transcript)	refseq:NP_055953.3|ensembl:ENSG00000137815(gene)|ensembl:ENST00000389629(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001711"(endodermal cell fate commitment)|go:"GO:0001832"(blastocyst growth)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016593"(Cdc73/Paf1 complex)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0080182"(histone H3-K4 trimethylation)|go:"GO:1990269"(RNA polymerase II C-terminal domain phosphoserine binding)|interpro:IPR004343(Plus-3)|interpro:IPR036128|mint:Q92541|rcsb pdb:2BZE|rcsb pdb:2DB9|rcsb pdb:3U1U|rcsb pdb:4L1P|rcsb pdb:4L1U|rcsb pdb:6TED|reactome:R-HSA-112382|reactome:R-HSA-674695|reactome:R-HSA-75955|reactome:R-HSA-8866654	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 5B|comment:Interaction with PAF1 complex only occurs in the presence of the BRE1 complex.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/06/01	2018/09/18	rogid:T6Mzgy6RHO9HoEIG3FmQvsP32vU9606	rogid:uWqJdVWJE0snWuZCdF0OkVWXRuI9606	intact-crc:F2F5053E5CA7161A|rigid:2Bx6WYJcajBgM55XnEoEwY0hKZs	false	glutathione s tranferase tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P49459	uniprotkb:Q8WVC0	intact:EBI-2339348|uniprotkb:A6NMF5|uniprotkb:Q96FX4|uniprotkb:B2R7R9|uniprotkb:Q4TTG1|uniprotkb:D3DWI1|uniprotkb:A6NFE9|uniprotkb:A6NGR2|ensembl:ENSP00000360613	intact:EBI-932432|uniprotkb:Q96N99|ensembl:ENSP00000299601	psi-mi:ube2a_human(display_long)|uniprotkb:UBE2A(gene name)|psi-mi:UBE2A(display_short)|uniprotkb:RAD6A(gene name synonym)|uniprotkb:Ubiquitin-protein ligase A(gene name synonym)|uniprotkb:Ubiquitin carrier protein A(gene name synonym)|uniprotkb:RAD6 homolog A(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme A(gene name synonym)	psi-mi:leo1_human(display_long)|uniprotkb:LEO1(gene name)|psi-mi:LEO1(display_short)|uniprotkb:RDL(gene name synonym)|uniprotkb:Replicative senescence down-regulated leo1-like protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Kim et al. (2009)	imex:IM-12178|pubmed:19410543	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2411060|imex:IM-12178-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003327.2|refseq:NP_861427.1|refseq:NP_001269090.1|dip:DIP-24260N|ensembl:ENSG00000077721(gene)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000785"(chromatin)|go:"GO:0001741"(XY body)|go:"GO:0001835"(blastocyst hatching)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009411"(response to UV)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033503"(HULC complex)|go:"GO:0033522"(histone H2A ubiquitination)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0060135"(maternal process involved in female pregnancy)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0070979"(protein K11-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|mint:P49459|rcsb pdb:6CYO|rcsb pdb:6CYR|reactome:R-HSA-8866652|reactome:R-HSA-8866654|reactome:R-HSA-983168|ensembl:ENST00000371558(transcript)	refseq:NP_001273359.1|refseq:NP_620147.1|dip:DIP-37885N|ensembl:ENSG00000166477(gene)|ensembl:ENST00000299601(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0001711"(endodermal cell fate commitment)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0006378"(mRNA polyadenylation)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016593"(Cdc73/Paf1 complex)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0031442"(positive regulation of mRNA 3'-end processing)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:1990269"(RNA polymerase II C-terminal domain phosphoserine binding)|interpro:IPR007149(Leo1-like protein)|mint:Q8WVC0|rcsb pdb:4M6T|rcsb pdb:6GMH|rcsb pdb:6TED|reactome:R-HSA-112382|reactome:R-HSA-201722|reactome:R-HSA-674695|reactome:R-HSA-75955|reactome:R-HSA-8866654	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 5B|comment:Interaction with PAF1 complex only occurs in the presence of the BRE1 complex.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/06/01	2018/09/18	rogid:T6Mzgy6RHO9HoEIG3FmQvsP32vU9606	rogid:o0aaW4nxzWuPZ8/pMZpa9Qz9oEA9606	intact-crc:F2F5053E5CA7161A|rigid:2Bx6WYJcajBgM55XnEoEwY0hKZs	false	glutathione s tranferase tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P49459	uniprotkb:Q9GZS3	intact:EBI-2339348|uniprotkb:A6NMF5|uniprotkb:Q96FX4|uniprotkb:B2R7R9|uniprotkb:Q4TTG1|uniprotkb:D3DWI1|uniprotkb:A6NFE9|uniprotkb:A6NGR2|ensembl:ENSP00000360613	intact:EBI-358545|uniprotkb:D3DW84|uniprotkb:Q6IA22|uniprotkb:Q7Z4X4|ensembl:ENSP00000267973|ensembl:ENSP00000453801	psi-mi:ube2a_human(display_long)|uniprotkb:UBE2A(gene name)|psi-mi:UBE2A(display_short)|uniprotkb:RAD6A(gene name synonym)|uniprotkb:Ubiquitin-protein ligase A(gene name synonym)|uniprotkb:Ubiquitin carrier protein A(gene name synonym)|uniprotkb:RAD6 homolog A(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme A(gene name synonym)	psi-mi:wdr61_human(display_long)|uniprotkb:WDR61(gene name)|psi-mi:WDR61(display_short)|uniprotkb:Meiotic recombination REC14 protein homolog(gene name synonym)|uniprotkb:SKI8 homolog(gene name synonym)	psi-mi:"MI:0096"(pull down)	Kim et al. (2009)	imex:IM-12178|pubmed:19410543	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2411060|imex:IM-12178-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003327.2|refseq:NP_861427.1|refseq:NP_001269090.1|dip:DIP-24260N|ensembl:ENSG00000077721(gene)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000785"(chromatin)|go:"GO:0001741"(XY body)|go:"GO:0001835"(blastocyst hatching)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009411"(response to UV)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033503"(HULC complex)|go:"GO:0033522"(histone H2A ubiquitination)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0060135"(maternal process involved in female pregnancy)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0070979"(protein K11-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|mint:P49459|rcsb pdb:6CYO|rcsb pdb:6CYR|reactome:R-HSA-8866652|reactome:R-HSA-8866654|reactome:R-HSA-983168|ensembl:ENST00000371558(transcript)	refseq:NP_079510.1|go:"GO:0080182"(histone H3-K4 trimethylation)|go:"GO:2001162"(positive regulation of histone H3-K79 methylation)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|mint:Q9GZS3|rcsb pdb:3OW8|rcsb pdb:6GMH|rcsb pdb:6TED|reactome:R-HSA-112382|reactome:R-HSA-429958|reactome:R-HSA-674695|reactome:R-HSA-75955|ensembl:ENSG00000140395(gene)|ensembl:ENST00000267973(transcript)|ensembl:ENST00000558311(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016593"(Cdc73/Paf1 complex)|go:"GO:0035327"|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0055087"(Ski complex)|reactome:R-HSA-8866654|refseq:XP_011520396.1|refseq:NP_001290176.1|refseq:NP_001290177.1|dip:DIP-36672N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 5B|comment:Interaction with PAF1 complex only occurs in the presence of the BRE1 complex.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/06/01	2018/09/18	rogid:T6Mzgy6RHO9HoEIG3FmQvsP32vU9606	rogid:yVcjv2BXXr3VFSR7OcJ/1u9L6gw9606	intact-crc:F2F5053E5CA7161A|rigid:2Bx6WYJcajBgM55XnEoEwY0hKZs	false	glutathione s tranferase tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P49459	uniprotkb:P28328	intact:EBI-2339348|uniprotkb:A6NMF5|uniprotkb:Q96FX4|uniprotkb:B2R7R9|uniprotkb:Q4TTG1|uniprotkb:D3DWI1|uniprotkb:A6NFE9|uniprotkb:A6NGR2|ensembl:ENSP00000360613	intact:EBI-713978|uniprotkb:Q567S6|ensembl:ENSP00000349543|ensembl:ENSP00000428590|ensembl:ENSP00000428638|uniprotkb:Q9BW41	psi-mi:ube2a_human(display_long)|uniprotkb:UBE2A(gene name)|psi-mi:UBE2A(display_short)|uniprotkb:RAD6A(gene name synonym)|uniprotkb:Ubiquitin-protein ligase A(gene name synonym)|uniprotkb:Ubiquitin carrier protein A(gene name synonym)|uniprotkb:RAD6 homolog A(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme A(gene name synonym)	psi-mi:pex2_human(display_long)|uniprotkb:Peroxin-2(gene name synonym)|uniprotkb:Peroxisomal membrane protein 3(gene name synonym)|uniprotkb:35 kDa peroxisomal membrane protein(gene name synonym)|uniprotkb:RING finger protein 72(gene name synonym)|uniprotkb:PEX2(gene name)|psi-mi:PEX2(display_short)|uniprotkb:PAF1(gene name synonym)|uniprotkb:PXMP3(gene name synonym)|uniprotkb:PMP3(gene name synonym)|uniprotkb:PMP35(gene name synonym)|uniprotkb:RNF72(gene name synonym)|uniprotkb:Peroxisome assembly factor 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Kim et al. (2009)	imex:IM-12178|pubmed:19410543	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2411060|imex:IM-12178-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003327.2|refseq:NP_861427.1|refseq:NP_001269090.1|dip:DIP-24260N|ensembl:ENSG00000077721(gene)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000785"(chromatin)|go:"GO:0001741"(XY body)|go:"GO:0001835"(blastocyst hatching)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009411"(response to UV)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033503"(HULC complex)|go:"GO:0033522"(histone H2A ubiquitination)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0060135"(maternal process involved in female pregnancy)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0070979"(protein K11-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|mint:P49459|rcsb pdb:6CYO|rcsb pdb:6CYR|reactome:R-HSA-8866652|reactome:R-HSA-8866654|reactome:R-HSA-983168|ensembl:ENST00000371558(transcript)	ensembl:ENSG00000164751(gene)|ensembl:ENST00000357039(transcript)|ensembl:ENST00000520103(transcript)|ensembl:ENST00000522527(transcript)|go:"GO:0000038"(very long-chain fatty acid metabolic process)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005779"(integral component of peroxisomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0007031"(peroxisome organization)|go:"GO:0016020"(membrane)|go:"GO:0016558"(protein import into peroxisome matrix)|go:"GO:0016593"(Cdc73/Paf1 complex)|go:"GO:0031648"(protein destabilization)|go:"GO:0046872"(metal ion binding)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR006845(Pex, N-terminal)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR018957|reactome:R-HSA-8866654|reactome:R-HSA-9033241|reactome:R-HSA-9603798|refseq:NP_000309.1|refseq:NP_001073336.1|refseq:NP_001165557.1|refseq:NP_001165558.1	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 5B|comment:Interaction with PAF1 complex only occurs in the presence of the BRE1 complex.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/06/01	2018/09/18	rogid:T6Mzgy6RHO9HoEIG3FmQvsP32vU9606	rogid:jRy3158OBvN/huC4vR4MSyMWuSg9606	intact-crc:F2F5053E5CA7161A|rigid:2Bx6WYJcajBgM55XnEoEwY0hKZs	false	glutathione s tranferase tag:?-?	flag tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P49459	uniprotkb:O75150	intact:EBI-2339348|uniprotkb:A6NMF5|uniprotkb:Q96FX4|uniprotkb:B2R7R9|uniprotkb:Q4TTG1|uniprotkb:D3DWI1|uniprotkb:A6NFE9|uniprotkb:A6NGR2|ensembl:ENSP00000360613	intact:EBI-744408|uniprotkb:Q6AHZ6|uniprotkb:Q6N005|uniprotkb:Q7L3T6|uniprotkb:Q8N615|uniprotkb:Q96T18|uniprotkb:Q9BSV9|uniprotkb:Q9HC82|ensembl:ENSP00000325677|uniprotkb:A0A024QZG0	psi-mi:ube2a_human(display_long)|uniprotkb:UBE2A(gene name)|psi-mi:UBE2A(display_short)|uniprotkb:RAD6A(gene name synonym)|uniprotkb:Ubiquitin-protein ligase A(gene name synonym)|uniprotkb:Ubiquitin carrier protein A(gene name synonym)|uniprotkb:RAD6 homolog A(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme A(gene name synonym)	psi-mi:bre1b_human(display_long)|uniprotkb:95 kDa retinoblastoma-associated protein(gene name synonym)|uniprotkb:RING finger protein 40(gene name synonym)|uniprotkb:RNF40(gene name)|psi-mi:RNF40(display_short)|uniprotkb:BRE1B(gene name synonym)|uniprotkb:KIAA0661(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BRE1B(gene name synonym)	psi-mi:"MI:0096"(pull down)	Kim et al. (2009)	imex:IM-12178|pubmed:19410543	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2411060|imex:IM-12178-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003327.2|refseq:NP_861427.1|refseq:NP_001269090.1|dip:DIP-24260N|ensembl:ENSG00000077721(gene)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000785"(chromatin)|go:"GO:0001741"(XY body)|go:"GO:0001835"(blastocyst hatching)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009411"(response to UV)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033503"(HULC complex)|go:"GO:0033522"(histone H2A ubiquitination)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0060135"(maternal process involved in female pregnancy)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0070979"(protein K11-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|mint:P49459|rcsb pdb:6CYO|rcsb pdb:6CYR|reactome:R-HSA-8866652|reactome:R-HSA-8866654|reactome:R-HSA-983168|ensembl:ENST00000371558(transcript)	refseq:NP_001273501.1|refseq:NP_001193962.1|refseq:NP_001193963.1|refseq:NP_055586.1|go:"GO:1900364"(negative regulation of mRNA polyadenylation)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902916"(positive regulation of protein polyubiquitination)|go:"GO:2001168"(positive regulation of histone H2B ubiquitination)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013956(E3 ubiquitin ligase, BRE1)|interpro:IPR017907|mint:O75150|reactome:R-HSA-8866654|go:"GO:0046872"(metal ion binding)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043679"(axon terminus)|go:"GO:0044877"(protein-containing complex binding)|ensembl:ENSG00000103549(gene)|ensembl:ENST00000324685(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0016020"(membrane)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033503"(HULC complex)	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 5B|comment:Interaction with PAF1 complex only occurs in the presence of the BRE1 complex.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/06/01	2018/09/18	rogid:T6Mzgy6RHO9HoEIG3FmQvsP32vU9606	rogid:POkQZhEBe4cw3Y9V3YOwJDgvYJ89606	intact-crc:F2F5053E5CA7161A|rigid:2Bx6WYJcajBgM55XnEoEwY0hKZs	false	glutathione s tranferase tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P49459	uniprotkb:Q6P1J9	intact:EBI-2339348|uniprotkb:A6NMF5|uniprotkb:Q96FX4|uniprotkb:B2R7R9|uniprotkb:Q4TTG1|uniprotkb:D3DWI1|uniprotkb:A6NFE9|uniprotkb:A6NGR2|ensembl:ENSP00000360613	intact:EBI-930143|uniprotkb:A6NLZ8|uniprotkb:Q6PK51|uniprotkb:Q96A07|uniprotkb:Q9H245|uniprotkb:Q9H5L7|uniprotkb:B2RBR2|ensembl:ENSP00000356405	psi-mi:ube2a_human(display_long)|uniprotkb:UBE2A(gene name)|psi-mi:UBE2A(display_short)|uniprotkb:RAD6A(gene name synonym)|uniprotkb:Ubiquitin-protein ligase A(gene name synonym)|uniprotkb:Ubiquitin carrier protein A(gene name synonym)|uniprotkb:RAD6 homolog A(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme A(gene name synonym)	psi-mi:cdc73_human(display_long)|uniprotkb:CDC73(gene name)|psi-mi:CDC73(display_short)|uniprotkb:C1orf28(gene name synonym)|uniprotkb:HRPT2(gene name synonym)|uniprotkb:Cell division cycle protein 73 homolog(gene name synonym)|uniprotkb:Hyperparathyroidism 2 protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Kim et al. (2009)	imex:IM-12178|pubmed:19410543	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2411060|imex:IM-12178-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003327.2|refseq:NP_861427.1|refseq:NP_001269090.1|dip:DIP-24260N|ensembl:ENSG00000077721(gene)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000785"(chromatin)|go:"GO:0001741"(XY body)|go:"GO:0001835"(blastocyst hatching)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009411"(response to UV)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033503"(HULC complex)|go:"GO:0033522"(histone H2A ubiquitination)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0060135"(maternal process involved in female pregnancy)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0070979"(protein K11-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|mint:P49459|rcsb pdb:6CYO|rcsb pdb:6CYR|reactome:R-HSA-8866652|reactome:R-HSA-8866654|reactome:R-HSA-983168|ensembl:ENST00000371558(transcript)	refseq:NP_078805.3|dip:DIP-37884N|ensembl:ENSG00000134371(gene)|ensembl:ENST00000367435(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001711"(endodermal cell fate commitment)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0006378"(mRNA polyadenylation)|go:"GO:0007049"(cell cycle)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016593"(Cdc73/Paf1 complex)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0031442"(positive regulation of mRNA 3'-end processing)|go:"GO:0031648"(protein destabilization)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0034402"(recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR007852(RNA polymerase II accessory factor, Cdc73)|interpro:IPR031336|interpro:IPR032041|interpro:IPR038103|mint:Q6P1J9|rcsb pdb:5YDE|rcsb pdb:5YDF|rcsb pdb:6TED|reactome:R-HSA-112382|reactome:R-HSA-201722|reactome:R-HSA-5632684|reactome:R-HSA-674695|reactome:R-HSA-75955|reactome:R-HSA-8866654	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 5B|comment:Interaction with PAF1 complex only occurs in the presence of the BRE1 complex.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/06/01	2018/09/18	rogid:T6Mzgy6RHO9HoEIG3FmQvsP32vU9606	rogid:nuJ2kK0petj8iBr17I2BQzxcVmE9606	intact-crc:F2F5053E5CA7161A|rigid:2Bx6WYJcajBgM55XnEoEwY0hKZs	false	glutathione s tranferase tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P49459	uniprotkb:Q6PD62	intact:EBI-2339348|uniprotkb:A6NMF5|uniprotkb:Q96FX4|uniprotkb:B2R7R9|uniprotkb:Q4TTG1|uniprotkb:D3DWI1|uniprotkb:A6NFE9|uniprotkb:A6NGR2|ensembl:ENSP00000360613	intact:EBI-1019583|uniprotkb:Q15015|uniprotkb:D3DQV8|ensembl:ENSP00000355013	psi-mi:ube2a_human(display_long)|uniprotkb:UBE2A(gene name)|psi-mi:UBE2A(display_short)|uniprotkb:RAD6A(gene name synonym)|uniprotkb:Ubiquitin-protein ligase A(gene name synonym)|uniprotkb:Ubiquitin carrier protein A(gene name synonym)|uniprotkb:RAD6 homolog A(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme A(gene name synonym)	psi-mi:ctr9_human(display_long)|uniprotkb:CTR9(gene name)|psi-mi:CTR9(display_short)|uniprotkb:KIAA0155(gene name synonym)|uniprotkb:SH2BP1(gene name synonym)|uniprotkb:SH2 domain-binding protein 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Kim et al. (2009)	imex:IM-12178|pubmed:19410543	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2411060|imex:IM-12178-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003327.2|refseq:NP_861427.1|refseq:NP_001269090.1|dip:DIP-24260N|ensembl:ENSG00000077721(gene)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000785"(chromatin)|go:"GO:0001741"(XY body)|go:"GO:0001835"(blastocyst hatching)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009411"(response to UV)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033503"(HULC complex)|go:"GO:0033522"(histone H2A ubiquitination)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0060135"(maternal process involved in female pregnancy)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0070979"(protein K11-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|mint:P49459|rcsb pdb:6CYO|rcsb pdb:6CYR|reactome:R-HSA-8866652|reactome:R-HSA-8866654|reactome:R-HSA-983168|ensembl:ENST00000371558(transcript)	refseq:NP_055448.1|ensembl:ENSG00000198730(gene)|ensembl:ENST00000361367(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001711"(endodermal cell fate commitment)|go:"GO:0001826"(inner cell mass cell differentiation)|go:"GO:0001829"(trophectodermal cell differentiation)|go:"GO:0001832"(blastocyst growth)|go:"GO:0001835"(blastocyst hatching)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016593"(Cdc73/Paf1 complex)|go:"GO:0016607"(nuclear speck)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0035327"|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0051569"(regulation of histone H3-K4 methylation)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0080182"(histone H3-K4 trimethylation)|go:"GO:1900364"(negative regulation of mRNA polyadenylation)|go:"GO:2000653"(regulation of genetic imprinting)|go:"GO:2001162"(positive regulation of histone H3-K79 methylation)|go:"GO:2001168"(positive regulation of histone H2B ubiquitination)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR031101|mint:Q6PD62|rcsb pdb:5ZYQ|rcsb pdb:6GMH|rcsb pdb:6TED|reactome:R-HSA-112382|reactome:R-HSA-674695|reactome:R-HSA-75955|reactome:R-HSA-8866654|dip:DIP-31693N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 5B|comment:Interaction with PAF1 complex only occurs in the presence of the BRE1 complex.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/06/01	2018/09/18	rogid:T6Mzgy6RHO9HoEIG3FmQvsP32vU9606	rogid:zEFAxq/VxkK8za6qsK0gcU+EU8o9606	intact-crc:F2F5053E5CA7161A|rigid:2Bx6WYJcajBgM55XnEoEwY0hKZs	false	glutathione s tranferase tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P63146	uniprotkb:Q6PD62	intact:EBI-712629|uniprotkb:P23567|uniprotkb:Q4PJ15|ensembl:ENSP00000265339|uniprotkb:Q9D0J6|uniprotkb:B2R503|uniprotkb:D3DQA2	intact:EBI-1019583|uniprotkb:Q15015|uniprotkb:D3DQV8|ensembl:ENSP00000355013	psi-mi:ube2b_human(display_long)|uniprotkb:Ubiquitin-protein ligase B(gene name synonym)|uniprotkb:Ubiquitin carrier protein B(gene name synonym)|uniprotkb:RAD6 homolog B(gene name synonym)|uniprotkb:Ubiquitin-conjugating enzyme E2-17 kDa(gene name synonym)|uniprotkb:UBE2B(gene name)|psi-mi:UBE2B(display_short)|uniprotkb:RAD6B(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme B(gene name synonym)	psi-mi:ctr9_human(display_long)|uniprotkb:CTR9(gene name)|psi-mi:CTR9(display_short)|uniprotkb:KIAA0155(gene name synonym)|uniprotkb:SH2BP1(gene name synonym)|uniprotkb:SH2 domain-binding protein 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Kim et al. (2009)	imex:IM-12178|pubmed:19410543	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2411076|imex:IM-12178-8	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000119048(gene)|ensembl:ENST00000265339(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000785"(chromatin)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001741"(XY body)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006281"(DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007288"(sperm axoneme assembly)|go:"GO:0009411"(response to UV)|go:"GO:0010845"(positive regulation of reciprocal meiotic recombination)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|interpro:IPR023313|mint:P63146|rcsb pdb:1JAS|rcsb pdb:1NXA|rcsb pdb:2Y4W|rcsb pdb:2YB6|rcsb pdb:2YBF|reactome:R-HSA-110314|reactome:R-HSA-8866652|reactome:R-HSA-8866654|reactome:R-HSA-983168|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033128"(negative regulation of histone phosphorylation)|go:"GO:0033503"(HULC complex)|go:"GO:0033522"(histone H2A ubiquitination)|go:"GO:0042493"|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043951"(negative regulation of cAMP-mediated signaling)|go:"GO:0045141"(meiotic telomere clustering)|go:"GO:0050821"(protein stabilization)|go:"GO:0051026"(chiasma assembly)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070076"(histone lysine demethylation)|go:"GO:0070193"(synaptonemal complex organization)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070829"(obsolete heterochromatin maintenance)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0070979"(protein K11-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|refseq:NP_003328.1|dip:DIP-29832N	refseq:NP_055448.1|ensembl:ENSG00000198730(gene)|ensembl:ENST00000361367(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001711"(endodermal cell fate commitment)|go:"GO:0001826"(inner cell mass cell differentiation)|go:"GO:0001829"(trophectodermal cell differentiation)|go:"GO:0001832"(blastocyst growth)|go:"GO:0001835"(blastocyst hatching)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016593"(Cdc73/Paf1 complex)|go:"GO:0016607"(nuclear speck)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0035327"|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0051569"(regulation of histone H3-K4 methylation)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0080182"(histone H3-K4 trimethylation)|go:"GO:1900364"(negative regulation of mRNA polyadenylation)|go:"GO:2000653"(regulation of genetic imprinting)|go:"GO:2001162"(positive regulation of histone H3-K79 methylation)|go:"GO:2001168"(positive regulation of histone H2B ubiquitination)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR031101|mint:Q6PD62|rcsb pdb:5ZYQ|rcsb pdb:6GMH|rcsb pdb:6TED|reactome:R-HSA-112382|reactome:R-HSA-674695|reactome:R-HSA-75955|reactome:R-HSA-8866654|dip:DIP-31693N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 5B|comment:Interaction with PAF1 complex only occurs in the presence of the BRE1 complex.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/06/01	2018/09/18	rogid:JvcUPH+3qQXicPsIRFnW19NOc3c9606	rogid:zEFAxq/VxkK8za6qsK0gcU+EU8o9606	intact-crc:4B2582C2A54033FB|rigid:fH5X3jmiDkF9UAX1kFZsuxY/AE8	false	glutathione s tranferase tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P63146	uniprotkb:P28328	intact:EBI-712629|uniprotkb:P23567|uniprotkb:Q4PJ15|ensembl:ENSP00000265339|uniprotkb:Q9D0J6|uniprotkb:B2R503|uniprotkb:D3DQA2	intact:EBI-713978|uniprotkb:Q567S6|ensembl:ENSP00000349543|ensembl:ENSP00000428590|ensembl:ENSP00000428638|uniprotkb:Q9BW41	psi-mi:ube2b_human(display_long)|uniprotkb:Ubiquitin-protein ligase B(gene name synonym)|uniprotkb:Ubiquitin carrier protein B(gene name synonym)|uniprotkb:RAD6 homolog B(gene name synonym)|uniprotkb:Ubiquitin-conjugating enzyme E2-17 kDa(gene name synonym)|uniprotkb:UBE2B(gene name)|psi-mi:UBE2B(display_short)|uniprotkb:RAD6B(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme B(gene name synonym)	psi-mi:pex2_human(display_long)|uniprotkb:Peroxin-2(gene name synonym)|uniprotkb:Peroxisomal membrane protein 3(gene name synonym)|uniprotkb:35 kDa peroxisomal membrane protein(gene name synonym)|uniprotkb:RING finger protein 72(gene name synonym)|uniprotkb:PEX2(gene name)|psi-mi:PEX2(display_short)|uniprotkb:PAF1(gene name synonym)|uniprotkb:PXMP3(gene name synonym)|uniprotkb:PMP3(gene name synonym)|uniprotkb:PMP35(gene name synonym)|uniprotkb:RNF72(gene name synonym)|uniprotkb:Peroxisome assembly factor 1(gene name synonym)	psi-mi:"MI:0096"(pull down)	Kim et al. (2009)	imex:IM-12178|pubmed:19410543	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2411076|imex:IM-12178-8	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000119048(gene)|ensembl:ENST00000265339(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000785"(chromatin)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001741"(XY body)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006281"(DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007288"(sperm axoneme assembly)|go:"GO:0009411"(response to UV)|go:"GO:0010845"(positive regulation of reciprocal meiotic recombination)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|interpro:IPR023313|mint:P63146|rcsb pdb:1JAS|rcsb pdb:1NXA|rcsb pdb:2Y4W|rcsb pdb:2YB6|rcsb pdb:2YBF|reactome:R-HSA-110314|reactome:R-HSA-8866652|reactome:R-HSA-8866654|reactome:R-HSA-983168|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033128"(negative regulation of histone phosphorylation)|go:"GO:0033503"(HULC complex)|go:"GO:0033522"(histone H2A ubiquitination)|go:"GO:0042493"|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043951"(negative regulation of cAMP-mediated signaling)|go:"GO:0045141"(meiotic telomere clustering)|go:"GO:0050821"(protein stabilization)|go:"GO:0051026"(chiasma assembly)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070076"(histone lysine demethylation)|go:"GO:0070193"(synaptonemal complex organization)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070829"(obsolete heterochromatin maintenance)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0070979"(protein K11-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|refseq:NP_003328.1|dip:DIP-29832N	ensembl:ENSG00000164751(gene)|ensembl:ENST00000357039(transcript)|ensembl:ENST00000520103(transcript)|ensembl:ENST00000522527(transcript)|go:"GO:0000038"(very long-chain fatty acid metabolic process)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005779"(integral component of peroxisomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0007031"(peroxisome organization)|go:"GO:0016020"(membrane)|go:"GO:0016558"(protein import into peroxisome matrix)|go:"GO:0016593"(Cdc73/Paf1 complex)|go:"GO:0031648"(protein destabilization)|go:"GO:0046872"(metal ion binding)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR006845(Pex, N-terminal)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR018957|reactome:R-HSA-8866654|reactome:R-HSA-9033241|reactome:R-HSA-9603798|refseq:NP_000309.1|refseq:NP_001073336.1|refseq:NP_001165557.1|refseq:NP_001165558.1	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 5B|comment:Interaction with PAF1 complex only occurs in the presence of the BRE1 complex.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/06/01	2018/09/18	rogid:JvcUPH+3qQXicPsIRFnW19NOc3c9606	rogid:jRy3158OBvN/huC4vR4MSyMWuSg9606	intact-crc:4B2582C2A54033FB|rigid:fH5X3jmiDkF9UAX1kFZsuxY/AE8	false	glutathione s tranferase tag:?-?	flag tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P63146	uniprotkb:Q9GZS3	intact:EBI-712629|uniprotkb:P23567|uniprotkb:Q4PJ15|ensembl:ENSP00000265339|uniprotkb:Q9D0J6|uniprotkb:B2R503|uniprotkb:D3DQA2	intact:EBI-358545|uniprotkb:D3DW84|uniprotkb:Q6IA22|uniprotkb:Q7Z4X4|ensembl:ENSP00000267973|ensembl:ENSP00000453801	psi-mi:ube2b_human(display_long)|uniprotkb:Ubiquitin-protein ligase B(gene name synonym)|uniprotkb:Ubiquitin carrier protein B(gene name synonym)|uniprotkb:RAD6 homolog B(gene name synonym)|uniprotkb:Ubiquitin-conjugating enzyme E2-17 kDa(gene name synonym)|uniprotkb:UBE2B(gene name)|psi-mi:UBE2B(display_short)|uniprotkb:RAD6B(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme B(gene name synonym)	psi-mi:wdr61_human(display_long)|uniprotkb:WDR61(gene name)|psi-mi:WDR61(display_short)|uniprotkb:Meiotic recombination REC14 protein homolog(gene name synonym)|uniprotkb:SKI8 homolog(gene name synonym)	psi-mi:"MI:0096"(pull down)	Kim et al. (2009)	imex:IM-12178|pubmed:19410543	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2411076|imex:IM-12178-8	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000119048(gene)|ensembl:ENST00000265339(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000785"(chromatin)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001741"(XY body)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006281"(DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007288"(sperm axoneme assembly)|go:"GO:0009411"(response to UV)|go:"GO:0010845"(positive regulation of reciprocal meiotic recombination)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|interpro:IPR023313|mint:P63146|rcsb pdb:1JAS|rcsb pdb:1NXA|rcsb pdb:2Y4W|rcsb pdb:2YB6|rcsb pdb:2YBF|reactome:R-HSA-110314|reactome:R-HSA-8866652|reactome:R-HSA-8866654|reactome:R-HSA-983168|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033128"(negative regulation of histone phosphorylation)|go:"GO:0033503"(HULC complex)|go:"GO:0033522"(histone H2A ubiquitination)|go:"GO:0042493"|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043951"(negative regulation of cAMP-mediated signaling)|go:"GO:0045141"(meiotic telomere clustering)|go:"GO:0050821"(protein stabilization)|go:"GO:0051026"(chiasma assembly)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070076"(histone lysine demethylation)|go:"GO:0070193"(synaptonemal complex organization)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070829"(obsolete heterochromatin maintenance)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0070979"(protein K11-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|refseq:NP_003328.1|dip:DIP-29832N	refseq:NP_079510.1|go:"GO:0080182"(histone H3-K4 trimethylation)|go:"GO:2001162"(positive regulation of histone H3-K79 methylation)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|mint:Q9GZS3|rcsb pdb:3OW8|rcsb pdb:6GMH|rcsb pdb:6TED|reactome:R-HSA-112382|reactome:R-HSA-429958|reactome:R-HSA-674695|reactome:R-HSA-75955|ensembl:ENSG00000140395(gene)|ensembl:ENST00000267973(transcript)|ensembl:ENST00000558311(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016593"(Cdc73/Paf1 complex)|go:"GO:0035327"|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0055087"(Ski complex)|reactome:R-HSA-8866654|refseq:XP_011520396.1|refseq:NP_001290176.1|refseq:NP_001290177.1|dip:DIP-36672N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 5B|comment:Interaction with PAF1 complex only occurs in the presence of the BRE1 complex.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/06/01	2018/09/18	rogid:JvcUPH+3qQXicPsIRFnW19NOc3c9606	rogid:yVcjv2BXXr3VFSR7OcJ/1u9L6gw9606	intact-crc:4B2582C2A54033FB|rigid:fH5X3jmiDkF9UAX1kFZsuxY/AE8	false	glutathione s tranferase tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P63146	uniprotkb:Q6P1J9	intact:EBI-712629|uniprotkb:P23567|uniprotkb:Q4PJ15|ensembl:ENSP00000265339|uniprotkb:Q9D0J6|uniprotkb:B2R503|uniprotkb:D3DQA2	intact:EBI-930143|uniprotkb:A6NLZ8|uniprotkb:Q6PK51|uniprotkb:Q96A07|uniprotkb:Q9H245|uniprotkb:Q9H5L7|uniprotkb:B2RBR2|ensembl:ENSP00000356405	psi-mi:ube2b_human(display_long)|uniprotkb:Ubiquitin-protein ligase B(gene name synonym)|uniprotkb:Ubiquitin carrier protein B(gene name synonym)|uniprotkb:RAD6 homolog B(gene name synonym)|uniprotkb:Ubiquitin-conjugating enzyme E2-17 kDa(gene name synonym)|uniprotkb:UBE2B(gene name)|psi-mi:UBE2B(display_short)|uniprotkb:RAD6B(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme B(gene name synonym)	psi-mi:cdc73_human(display_long)|uniprotkb:CDC73(gene name)|psi-mi:CDC73(display_short)|uniprotkb:C1orf28(gene name synonym)|uniprotkb:HRPT2(gene name synonym)|uniprotkb:Cell division cycle protein 73 homolog(gene name synonym)|uniprotkb:Hyperparathyroidism 2 protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Kim et al. (2009)	imex:IM-12178|pubmed:19410543	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2411076|imex:IM-12178-8	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000119048(gene)|ensembl:ENST00000265339(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000785"(chromatin)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001741"(XY body)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006281"(DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007288"(sperm axoneme assembly)|go:"GO:0009411"(response to UV)|go:"GO:0010845"(positive regulation of reciprocal meiotic recombination)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|interpro:IPR023313|mint:P63146|rcsb pdb:1JAS|rcsb pdb:1NXA|rcsb pdb:2Y4W|rcsb pdb:2YB6|rcsb pdb:2YBF|reactome:R-HSA-110314|reactome:R-HSA-8866652|reactome:R-HSA-8866654|reactome:R-HSA-983168|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033128"(negative regulation of histone phosphorylation)|go:"GO:0033503"(HULC complex)|go:"GO:0033522"(histone H2A ubiquitination)|go:"GO:0042493"|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043951"(negative regulation of cAMP-mediated signaling)|go:"GO:0045141"(meiotic telomere clustering)|go:"GO:0050821"(protein stabilization)|go:"GO:0051026"(chiasma assembly)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070076"(histone lysine demethylation)|go:"GO:0070193"(synaptonemal complex organization)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070829"(obsolete heterochromatin maintenance)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0070979"(protein K11-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|refseq:NP_003328.1|dip:DIP-29832N	refseq:NP_078805.3|dip:DIP-37884N|ensembl:ENSG00000134371(gene)|ensembl:ENST00000367435(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001711"(endodermal cell fate commitment)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0006378"(mRNA polyadenylation)|go:"GO:0007049"(cell cycle)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016593"(Cdc73/Paf1 complex)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0031442"(positive regulation of mRNA 3'-end processing)|go:"GO:0031648"(protein destabilization)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0034402"(recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR007852(RNA polymerase II accessory factor, Cdc73)|interpro:IPR031336|interpro:IPR032041|interpro:IPR038103|mint:Q6P1J9|rcsb pdb:5YDE|rcsb pdb:5YDF|rcsb pdb:6TED|reactome:R-HSA-112382|reactome:R-HSA-201722|reactome:R-HSA-5632684|reactome:R-HSA-674695|reactome:R-HSA-75955|reactome:R-HSA-8866654	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 5B|comment:Interaction with PAF1 complex only occurs in the presence of the BRE1 complex.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/06/01	2018/09/18	rogid:JvcUPH+3qQXicPsIRFnW19NOc3c9606	rogid:nuJ2kK0petj8iBr17I2BQzxcVmE9606	intact-crc:4B2582C2A54033FB|rigid:fH5X3jmiDkF9UAX1kFZsuxY/AE8	false	glutathione s tranferase tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P63146	uniprotkb:Q5VTR2	intact:EBI-712629|uniprotkb:P23567|uniprotkb:Q4PJ15|ensembl:ENSP00000265339|uniprotkb:Q9D0J6|uniprotkb:B2R503|uniprotkb:D3DQA2	intact:EBI-2372238|uniprotkb:Q2TB34|uniprotkb:Q69YL5|uniprotkb:Q6P527|uniprotkb:Q8N3J4|uniprotkb:Q96JD3|uniprotkb:Q9H9Y7|uniprotkb:Q9HA51|uniprotkb:Q9NUR4|uniprotkb:Q9NWQ3|uniprotkb:Q9NX83|uniprotkb:A7MCT5|ensembl:ENSP00000373772	psi-mi:ube2b_human(display_long)|uniprotkb:Ubiquitin-protein ligase B(gene name synonym)|uniprotkb:Ubiquitin carrier protein B(gene name synonym)|uniprotkb:RAD6 homolog B(gene name synonym)|uniprotkb:Ubiquitin-conjugating enzyme E2-17 kDa(gene name synonym)|uniprotkb:UBE2B(gene name)|psi-mi:UBE2B(display_short)|uniprotkb:RAD6B(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme B(gene name synonym)	psi-mi:bre1a_human(display_long)|uniprotkb:RNF20(gene name)|psi-mi:RNF20(display_short)|uniprotkb:BRE1A(gene name synonym)|uniprotkb:RING finger protein 20(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BRE1A(gene name synonym)	psi-mi:"MI:0096"(pull down)	Kim et al. (2009)	imex:IM-12178|pubmed:19410543	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2411076|imex:IM-12178-8	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000119048(gene)|ensembl:ENST00000265339(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000785"(chromatin)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001741"(XY body)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006281"(DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007288"(sperm axoneme assembly)|go:"GO:0009411"(response to UV)|go:"GO:0010845"(positive regulation of reciprocal meiotic recombination)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|interpro:IPR023313|mint:P63146|rcsb pdb:1JAS|rcsb pdb:1NXA|rcsb pdb:2Y4W|rcsb pdb:2YB6|rcsb pdb:2YBF|reactome:R-HSA-110314|reactome:R-HSA-8866652|reactome:R-HSA-8866654|reactome:R-HSA-983168|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033128"(negative regulation of histone phosphorylation)|go:"GO:0033503"(HULC complex)|go:"GO:0033522"(histone H2A ubiquitination)|go:"GO:0042493"|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043951"(negative regulation of cAMP-mediated signaling)|go:"GO:0045141"(meiotic telomere clustering)|go:"GO:0050821"(protein stabilization)|go:"GO:0051026"(chiasma assembly)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070076"(histone lysine demethylation)|go:"GO:0070193"(synaptonemal complex organization)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070829"(obsolete heterochromatin maintenance)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0070979"(protein K11-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|refseq:NP_003328.1|dip:DIP-29832N	refseq:XP_011517164.1|refseq:NP_062538.5|dip:DIP-53411N|ensembl:ENSG00000155827(gene)|ensembl:ENST00000389120(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002039"(p53 binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0031062"(positive regulation of histone methylation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033503"(HULC complex)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0042393"(histone binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:1900364"(negative regulation of mRNA polyadenylation)|go:"GO:2001168"(positive regulation of histone H2B ubiquitination)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013956(E3 ubiquitin ligase, BRE1)|interpro:IPR017907|mint:Q5VTR2|rcsb pdb:5TRB|reactome:R-HSA-8866654|reactome:R-HSA-9013422	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 5B|comment:Interaction with PAF1 complex only occurs in the presence of the BRE1 complex.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/06/01	2018/09/18	rogid:JvcUPH+3qQXicPsIRFnW19NOc3c9606	rogid:zscBhEtpu0D69sPn1wXsEGBIiOY9606	intact-crc:4B2582C2A54033FB|rigid:fH5X3jmiDkF9UAX1kFZsuxY/AE8	false	glutathione s tranferase tag:?-?	his tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P63146	uniprotkb:Q92541	intact:EBI-712629|uniprotkb:P23567|uniprotkb:Q4PJ15|ensembl:ENSP00000265339|uniprotkb:Q9D0J6|uniprotkb:B2R503|uniprotkb:D3DQA2	intact:EBI-1055239|uniprotkb:Q96BX6|ensembl:ENSP00000374280	psi-mi:ube2b_human(display_long)|uniprotkb:Ubiquitin-protein ligase B(gene name synonym)|uniprotkb:Ubiquitin carrier protein B(gene name synonym)|uniprotkb:RAD6 homolog B(gene name synonym)|uniprotkb:Ubiquitin-conjugating enzyme E2-17 kDa(gene name synonym)|uniprotkb:UBE2B(gene name)|psi-mi:UBE2B(display_short)|uniprotkb:RAD6B(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme B(gene name synonym)	psi-mi:rtf1_human(display_long)|uniprotkb:RTF1(gene name)|psi-mi:RTF1(display_short)|uniprotkb:KIAA0252(gene name synonym)	psi-mi:"MI:0096"(pull down)	Kim et al. (2009)	imex:IM-12178|pubmed:19410543	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2411076|imex:IM-12178-8	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000119048(gene)|ensembl:ENST00000265339(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000785"(chromatin)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001741"(XY body)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006281"(DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007288"(sperm axoneme assembly)|go:"GO:0009411"(response to UV)|go:"GO:0010845"(positive regulation of reciprocal meiotic recombination)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|interpro:IPR023313|mint:P63146|rcsb pdb:1JAS|rcsb pdb:1NXA|rcsb pdb:2Y4W|rcsb pdb:2YB6|rcsb pdb:2YBF|reactome:R-HSA-110314|reactome:R-HSA-8866652|reactome:R-HSA-8866654|reactome:R-HSA-983168|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033128"(negative regulation of histone phosphorylation)|go:"GO:0033503"(HULC complex)|go:"GO:0033522"(histone H2A ubiquitination)|go:"GO:0042493"|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043951"(negative regulation of cAMP-mediated signaling)|go:"GO:0045141"(meiotic telomere clustering)|go:"GO:0050821"(protein stabilization)|go:"GO:0051026"(chiasma assembly)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070076"(histone lysine demethylation)|go:"GO:0070193"(synaptonemal complex organization)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070829"(obsolete heterochromatin maintenance)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0070979"(protein K11-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|refseq:NP_003328.1|dip:DIP-29832N	refseq:NP_055953.3|ensembl:ENSG00000137815(gene)|ensembl:ENST00000389629(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001711"(endodermal cell fate commitment)|go:"GO:0001832"(blastocyst growth)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016593"(Cdc73/Paf1 complex)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0080182"(histone H3-K4 trimethylation)|go:"GO:1990269"(RNA polymerase II C-terminal domain phosphoserine binding)|interpro:IPR004343(Plus-3)|interpro:IPR036128|mint:Q92541|rcsb pdb:2BZE|rcsb pdb:2DB9|rcsb pdb:3U1U|rcsb pdb:4L1P|rcsb pdb:4L1U|rcsb pdb:6TED|reactome:R-HSA-112382|reactome:R-HSA-674695|reactome:R-HSA-75955|reactome:R-HSA-8866654	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 5B|comment:Interaction with PAF1 complex only occurs in the presence of the BRE1 complex.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/06/01	2018/09/18	rogid:JvcUPH+3qQXicPsIRFnW19NOc3c9606	rogid:uWqJdVWJE0snWuZCdF0OkVWXRuI9606	intact-crc:4B2582C2A54033FB|rigid:fH5X3jmiDkF9UAX1kFZsuxY/AE8	false	glutathione s tranferase tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P63146	uniprotkb:O75150	intact:EBI-712629|uniprotkb:P23567|uniprotkb:Q4PJ15|ensembl:ENSP00000265339|uniprotkb:Q9D0J6|uniprotkb:B2R503|uniprotkb:D3DQA2	intact:EBI-744408|uniprotkb:Q6AHZ6|uniprotkb:Q6N005|uniprotkb:Q7L3T6|uniprotkb:Q8N615|uniprotkb:Q96T18|uniprotkb:Q9BSV9|uniprotkb:Q9HC82|ensembl:ENSP00000325677|uniprotkb:A0A024QZG0	psi-mi:ube2b_human(display_long)|uniprotkb:Ubiquitin-protein ligase B(gene name synonym)|uniprotkb:Ubiquitin carrier protein B(gene name synonym)|uniprotkb:RAD6 homolog B(gene name synonym)|uniprotkb:Ubiquitin-conjugating enzyme E2-17 kDa(gene name synonym)|uniprotkb:UBE2B(gene name)|psi-mi:UBE2B(display_short)|uniprotkb:RAD6B(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme B(gene name synonym)	psi-mi:bre1b_human(display_long)|uniprotkb:95 kDa retinoblastoma-associated protein(gene name synonym)|uniprotkb:RING finger protein 40(gene name synonym)|uniprotkb:RNF40(gene name)|psi-mi:RNF40(display_short)|uniprotkb:BRE1B(gene name synonym)|uniprotkb:KIAA0661(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BRE1B(gene name synonym)	psi-mi:"MI:0096"(pull down)	Kim et al. (2009)	imex:IM-12178|pubmed:19410543	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2411076|imex:IM-12178-8	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000119048(gene)|ensembl:ENST00000265339(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000785"(chromatin)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001741"(XY body)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006281"(DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007288"(sperm axoneme assembly)|go:"GO:0009411"(response to UV)|go:"GO:0010845"(positive regulation of reciprocal meiotic recombination)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|interpro:IPR023313|mint:P63146|rcsb pdb:1JAS|rcsb pdb:1NXA|rcsb pdb:2Y4W|rcsb pdb:2YB6|rcsb pdb:2YBF|reactome:R-HSA-110314|reactome:R-HSA-8866652|reactome:R-HSA-8866654|reactome:R-HSA-983168|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033128"(negative regulation of histone phosphorylation)|go:"GO:0033503"(HULC complex)|go:"GO:0033522"(histone H2A ubiquitination)|go:"GO:0042493"|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043951"(negative regulation of cAMP-mediated signaling)|go:"GO:0045141"(meiotic telomere clustering)|go:"GO:0050821"(protein stabilization)|go:"GO:0051026"(chiasma assembly)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070076"(histone lysine demethylation)|go:"GO:0070193"(synaptonemal complex organization)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070829"(obsolete heterochromatin maintenance)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0070979"(protein K11-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|refseq:NP_003328.1|dip:DIP-29832N	refseq:NP_001273501.1|refseq:NP_001193962.1|refseq:NP_001193963.1|refseq:NP_055586.1|go:"GO:1900364"(negative regulation of mRNA polyadenylation)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902916"(positive regulation of protein polyubiquitination)|go:"GO:2001168"(positive regulation of histone H2B ubiquitination)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013956(E3 ubiquitin ligase, BRE1)|interpro:IPR017907|mint:O75150|reactome:R-HSA-8866654|go:"GO:0046872"(metal ion binding)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043679"(axon terminus)|go:"GO:0044877"(protein-containing complex binding)|ensembl:ENSG00000103549(gene)|ensembl:ENST00000324685(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0016020"(membrane)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033503"(HULC complex)	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 5B|comment:Interaction with PAF1 complex only occurs in the presence of the BRE1 complex.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/06/01	2018/09/18	rogid:JvcUPH+3qQXicPsIRFnW19NOc3c9606	rogid:POkQZhEBe4cw3Y9V3YOwJDgvYJ89606	intact-crc:4B2582C2A54033FB|rigid:fH5X3jmiDkF9UAX1kFZsuxY/AE8	false	glutathione s tranferase tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P63146	uniprotkb:Q8WVC0	intact:EBI-712629|uniprotkb:P23567|uniprotkb:Q4PJ15|ensembl:ENSP00000265339|uniprotkb:Q9D0J6|uniprotkb:B2R503|uniprotkb:D3DQA2	intact:EBI-932432|uniprotkb:Q96N99|ensembl:ENSP00000299601	psi-mi:ube2b_human(display_long)|uniprotkb:Ubiquitin-protein ligase B(gene name synonym)|uniprotkb:Ubiquitin carrier protein B(gene name synonym)|uniprotkb:RAD6 homolog B(gene name synonym)|uniprotkb:Ubiquitin-conjugating enzyme E2-17 kDa(gene name synonym)|uniprotkb:UBE2B(gene name)|psi-mi:UBE2B(display_short)|uniprotkb:RAD6B(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme B(gene name synonym)	psi-mi:leo1_human(display_long)|uniprotkb:LEO1(gene name)|psi-mi:LEO1(display_short)|uniprotkb:RDL(gene name synonym)|uniprotkb:Replicative senescence down-regulated leo1-like protein(gene name synonym)	psi-mi:"MI:0096"(pull down)	Kim et al. (2009)	imex:IM-12178|pubmed:19410543	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2411076|imex:IM-12178-8	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000119048(gene)|ensembl:ENST00000265339(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000785"(chromatin)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001741"(XY body)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006281"(DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007288"(sperm axoneme assembly)|go:"GO:0009411"(response to UV)|go:"GO:0010845"(positive regulation of reciprocal meiotic recombination)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|interpro:IPR023313|mint:P63146|rcsb pdb:1JAS|rcsb pdb:1NXA|rcsb pdb:2Y4W|rcsb pdb:2YB6|rcsb pdb:2YBF|reactome:R-HSA-110314|reactome:R-HSA-8866652|reactome:R-HSA-8866654|reactome:R-HSA-983168|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033128"(negative regulation of histone phosphorylation)|go:"GO:0033503"(HULC complex)|go:"GO:0033522"(histone H2A ubiquitination)|go:"GO:0042493"|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043951"(negative regulation of cAMP-mediated signaling)|go:"GO:0045141"(meiotic telomere clustering)|go:"GO:0050821"(protein stabilization)|go:"GO:0051026"(chiasma assembly)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070076"(histone lysine demethylation)|go:"GO:0070193"(synaptonemal complex organization)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070829"(obsolete heterochromatin maintenance)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0070979"(protein K11-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|refseq:NP_003328.1|dip:DIP-29832N	refseq:NP_001273359.1|refseq:NP_620147.1|dip:DIP-37885N|ensembl:ENSG00000166477(gene)|ensembl:ENST00000299601(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0001711"(endodermal cell fate commitment)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0006378"(mRNA polyadenylation)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016593"(Cdc73/Paf1 complex)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0031442"(positive regulation of mRNA 3'-end processing)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:1990269"(RNA polymerase II C-terminal domain phosphoserine binding)|interpro:IPR007149(Leo1-like protein)|mint:Q8WVC0|rcsb pdb:4M6T|rcsb pdb:6GMH|rcsb pdb:6TED|reactome:R-HSA-112382|reactome:R-HSA-201722|reactome:R-HSA-674695|reactome:R-HSA-75955|reactome:R-HSA-8866654	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 5B|comment:Interaction with PAF1 complex only occurs in the presence of the BRE1 complex.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/06/01	2018/09/18	rogid:JvcUPH+3qQXicPsIRFnW19NOc3c9606	rogid:o0aaW4nxzWuPZ8/pMZpa9Qz9oEA9606	intact-crc:4B2582C2A54033FB|rigid:fH5X3jmiDkF9UAX1kFZsuxY/AE8	false	glutathione s tranferase tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P04637	uniprotkb:O75150	intact:EBI-366083|uniprotkb:Q15086|uniprotkb:Q15087|uniprotkb:Q15088|uniprotkb:Q16535|uniprotkb:Q16807|uniprotkb:Q16808|uniprotkb:Q16809|uniprotkb:Q16810|uniprotkb:Q16811|uniprotkb:Q16848|uniprotkb:Q86UG1|uniprotkb:Q8J016|uniprotkb:Q99659|uniprotkb:Q9BTM4|uniprotkb:Q9HAQ8|uniprotkb:Q9NP68|uniprotkb:Q9NPJ2|uniprotkb:Q9NZD0|uniprotkb:Q9UBI2|uniprotkb:Q9UQ61|ensembl:ENSP00000269305|ensembl:ENSP00000391478|intact:EBI-28980681|uniprotkb:Q2XN98|uniprotkb:Q3LRW1|uniprotkb:Q3LRW2|uniprotkb:Q3LRW3|uniprotkb:Q3LRW4|uniprotkb:Q3LRW5	intact:EBI-744408|uniprotkb:Q6AHZ6|uniprotkb:Q6N005|uniprotkb:Q7L3T6|uniprotkb:Q8N615|uniprotkb:Q96T18|uniprotkb:Q9BSV9|uniprotkb:Q9HC82|ensembl:ENSP00000325677|uniprotkb:A0A024QZG0	psi-mi:p53_human(display_long)|uniprotkb:TP53(gene name)|psi-mi:TP53(display_short)|uniprotkb:P53(gene name synonym)|uniprotkb:Tumor suppressor p53(gene name synonym)|uniprotkb:Phosphoprotein p53(gene name synonym)|uniprotkb:Antigen NY-CO-13(gene name synonym)	psi-mi:bre1b_human(display_long)|uniprotkb:95 kDa retinoblastoma-associated protein(gene name synonym)|uniprotkb:RING finger protein 40(gene name synonym)|uniprotkb:RNF40(gene name)|psi-mi:RNF40(display_short)|uniprotkb:BRE1B(gene name synonym)|uniprotkb:KIAA0661(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BRE1B(gene name synonym)	psi-mi:"MI:0096"(pull down)	Kim et al. (2009)	imex:IM-12178|pubmed:19410543	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2411186|imex:IM-12178-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001263624.1|refseq:NP_001263625.1|ensembl:ENSG00000141510(gene)|ensembl:ENST00000269305(transcript)|ensembl:ENST00000445888(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0001094"(TFIID-class transcription factor complex binding)|go:"GO:0001216"(DNA-binding transcription activator activity)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001756"(somitogenesis)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0002020"(protease binding)|go:"GO:0002039"(p53 binding)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002309"(T cell proliferation involved in immune response)|go:"GO:0002360"(T cell lineage commitment)|go:"GO:0002326"(B cell lineage commitment)|go:"GO:0031497"(chromatin assembly)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034103"(regulation of tissue remodeling)|go:"GO:0034613"(cellular protein localization)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035033"(histone deacetylase regulator activity)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035690"|go:"GO:0035794"(positive regulation of mitochondrial membrane permeability)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036003"(positive regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0036310"(ATP-dependent DNA/DNA annealing activity)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0002931"(response to ischemia)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006914"(autophagy)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006977"(DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)|go:"GO:0006978"(DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator)|go:"GO:0006983"(ER overload response)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007369"(gastrulation)|go:"GO:0007406"(negative regulation of neuroblast proliferation)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0043504"(mitochondrial DNA repair)|go:"GO:0043516"(regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0043621"(protein self-association)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045899"(positive regulation of RNA polymerase II transcription preinitiation complex assembly)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0048512"(circadian behavior)|go:"GO:0048539"(bone marrow development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051097"(negative regulation of helicase activity)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0062100"(positive regulation of programmed necrotic cell death)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0060411"(cardiac septum morphogenesis)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070245"(positive regulation of thymocyte apoptotic process)|go:"GO:0070266"(necroptotic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0071494"(cellular response to UV-C)|go:"GO:0072331"(signal transduction by p53 class mediator)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0072717"(cellular response to actinomycin D)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0090343"(positive regulation of cell aging)|go:"GO:0090399"(replicative senescence)|go:"GO:0090403"(oxidative stress-induced premature senescence)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0097252"(oligodendrocyte apoptotic process)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0140296"(general transcription initiation factor binding)|go:"GO:1900119"(positive regulation of execution phase of apoptosis)|go:"GO:1901525"(negative regulation of mitophagy)|go:"GO:1902108"(regulation of mitochondrial membrane permeability involved in apoptotic process)|go:"GO:1902253"(regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904024"(negative regulation of glucose catabolic process to lactate via pyruvate)|go:"GO:1905856"(negative regulation of pentose-phosphate shunt)|go:"GO:1990144"(intrinsic apoptotic signaling pathway in response to hypoxia)|go:"GO:1990248"(regulation of transcription from RNA polymerase II promoter in response to DNA damage)|go:"GO:1990440"(positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000269"(regulation of fibroblast apoptotic process)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000772"(regulation of cellular senescence)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002117(p53 tumor antigen)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR010991(p53, tetramerisation)|interpro:IPR011615(p53, DNA-binding)|go:"GO:0007569"(cell aging)|go:"GO:0008104"(protein localization)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008156"(negative regulation of DNA replication)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009299"(mRNA transcription)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009651"(response to salt stress)|go:"GO:0010165"(response to X-ray)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0016032"(viral process)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016605"(PML body)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031065"(positive regulation of histone deacetylation)|interpro:IPR012346(p53 and RUNT-type transcription factor, DNA-binding)|interpro:IPR013872("p53 transactivation domain (TAD)")|interpro:IPR036674|interpro:IPR040926|rcsb pdb:2ATA|rcsb pdb:2B3G|rcsb pdb:2BIM|rcsb pdb:2BIN|rcsb pdb:2BIO|rcsb pdb:2BIP|rcsb pdb:2AHI|rcsb pdb:2BIQ|rcsb pdb:2F1X|rcsb pdb:2FEJ|rcsb pdb:2FOJ|rcsb pdb:2FOO|rcsb pdb:2GS0|rcsb pdb:2H1L|rcsb pdb:2H2D|rcsb pdb:2H2F|rcsb pdb:2H4F|rcsb pdb:2H4H|rcsb pdb:2H4J|rcsb pdb:2H59|rcsb pdb:2J0Z|rcsb pdb:2J10|rcsb pdb:2J11|rcsb pdb:2J1W|rcsb pdb:2J1X|rcsb pdb:2J1Y|rcsb pdb:2J1Z|rcsb pdb:2J20|rcsb pdb:2J21|rcsb pdb:2K8F|rcsb pdb:2L14|rcsb pdb:2LY4|rcsb pdb:2MEJ|rcsb pdb:2MWO|rcsb pdb:2MWP|rcsb pdb:2MWY|rcsb pdb:2MZD|rcsb pdb:2OCJ|rcsb pdb:2PCX|rcsb pdb:1A1U|rcsb pdb:1AIE|rcsb pdb:1C26|rcsb pdb:1DT7|rcsb pdb:1GZH|rcsb pdb:1H26|rcsb pdb:1HS5|rcsb pdb:1JSP|rcsb pdb:1KZY|rcsb pdb:1MA3|rcsb pdb:1OLG|rcsb pdb:1OLH|rcsb pdb:1PES|rcsb pdb:1PET|mint:P04637|rcsb pdb:1SAE|rcsb pdb:1SAF|rcsb pdb:1SAK|rcsb pdb:1SAL|rcsb pdb:1TSR|rcsb pdb:1TUP|rcsb pdb:1UOL|rcsb pdb:1XQH|rcsb pdb:1YC5|rcsb pdb:1YCQ|rcsb pdb:1YCR|rcsb pdb:1YCS|rcsb pdb:2AC0|rcsb pdb:2ADY|refseq:NP_000537.3|refseq:NP_001119584.1|refseq:NP_001119585.1|refseq:NP_001119586.1|refseq:NP_001119587.1|refseq:NP_001119588.1|refseq:NP_001119589.1|rcsb pdb:2RUK|rcsb pdb:2VUK|rcsb pdb:3Q06|rcsb pdb:2WGX|rcsb pdb:2X0U|rcsb pdb:2X0V|rcsb pdb:2X0W|rcsb pdb:2XWR|rcsb pdb:2YBG|rcsb pdb:2YDR|rcsb pdb:2Z5S|rcsb pdb:2Z5T|rcsb pdb:3SAK|rcsb pdb:3D05|rcsb pdb:3D06|rcsb pdb:3D07|rcsb pdb:3D08|rcsb pdb:3D09|rcsb pdb:3D0A|rcsb pdb:3DAB|rcsb pdb:3DAC|rcsb pdb:3IGK|rcsb pdb:3IGL|rcsb pdb:3KMD|rcsb pdb:3TG5|rcsb pdb:3KZ8|rcsb pdb:3LW1|rcsb pdb:3OQ5|rcsb pdb:3PDH|rcsb pdb:3Q01|rcsb pdb:3Q05|rcsb pdb:3TS8|rcsb pdb:3ZME|rcsb pdb:4AGM|rcsb pdb:4AGN|rcsb pdb:4AGO|rcsb pdb:4AGP|rcsb pdb:4AGQ|rcsb pdb:4BUZ|rcsb pdb:4BV2|rcsb pdb:4HFZ|rcsb pdb:4HJE|rcsb pdb:4IBQ|rcsb pdb:4IBS|rcsb pdb:4IBT|rcsb pdb:4IBU|rcsb pdb:4IBV|rcsb pdb:4IBW|rcsb pdb:4IBY|rcsb pdb:4IBZ|rcsb pdb:4IJT|rcsb pdb:4KVP|rcsb pdb:4LO9|rcsb pdb:4LOE|rcsb pdb:4LOF|rcsb pdb:4MZI|rcsb pdb:4MZR|rcsb pdb:4QO1|rcsb pdb:4RP6|rcsb pdb:4RP7|rcsb pdb:4X34|rcsb pdb:4XR8|rcsb pdb:4ZZJ|rcsb pdb:5A7B|rcsb pdb:5AB9|rcsb pdb:5ABA|rcsb pdb:4AGL|rcsb pdb:5AOI|rcsb pdb:5AOJ|rcsb pdb:5AOK|rcsb pdb:5AOL|rcsb pdb:5AOM|rcsb pdb:6XRE|rcsb pdb:7BWN|rcsb pdb:7DHY|rcsb pdb:7DHZ|rcsb pdb:7EL4|reactome:R-HSA-111448|reactome:R-HSA-139915|reactome:R-HSA-1912408|reactome:R-HSA-2559580|reactome:R-HSA-2559584|reactome:R-HSA-2559585|reactome:R-HSA-2559586|reactome:R-HSA-3232118|reactome:R-HSA-349425|reactome:R-HSA-390471|reactome:R-HSA-5620971|reactome:R-HSA-5628897|reactome:R-HSA-5689880|reactome:R-HSA-5689896|reactome:R-HSA-5693565|reactome:R-HSA-6785807|reactome:R-HSA-6796648|reactome:R-HSA-6803204|reactome:R-HSA-6803205|reactome:R-HSA-6803207|reactome:R-HSA-6803211|reactome:R-HSA-6804114|reactome:R-HSA-6804115|reactome:R-HSA-6804116|reactome:R-HSA-6804754|reactome:R-HSA-6804756|reactome:R-HSA-6804757|reactome:R-HSA-6804758|reactome:R-HSA-6804759|reactome:R-HSA-6804760|reactome:R-HSA-6811555|reactome:R-HSA-69473|reactome:R-HSA-69481|reactome:R-HSA-69541|reactome:R-HSA-69895|reactome:R-HSA-8852276|reactome:R-HSA-8853884|reactome:R-HSA-8941855|reactome:R-HSA-8943724|reactome:R-HSA-983231|rcsb pdb:5ECG|rcsb pdb:5G4M|rcsb pdb:5G4N|rcsb pdb:5BUA|rcsb pdb:5G4O|rcsb pdb:5HOU|rcsb pdb:5HP0|rcsb pdb:5HPD|rcsb pdb:5LAP|rcsb pdb:5LGY|rcsb pdb:5MCT|rcsb pdb:5MCU|rcsb pdb:5MCV|rcsb pdb:5MCW|rcsb pdb:5MF7|rcsb pdb:5MG7|rcsb pdb:5MHC|rcsb pdb:5MOC|rcsb pdb:5O1A|rcsb pdb:5O1B|rcsb pdb:5O1C|rcsb pdb:5O1D|rcsb pdb:5O1E|rcsb pdb:5O1F|rcsb pdb:5O1G|rcsb pdb:5O1H|rcsb pdb:5O1I|rcsb pdb:5OL0|rcsb pdb:5UN8|rcsb pdb:5XZC|rcsb pdb:6FF9|rcsb pdb:6FJ5|rcsb pdb:6GGA|rcsb pdb:6GGB|rcsb pdb:6GGC|rcsb pdb:6GGD|rcsb pdb:6GGE|rcsb pdb:6GGF|rcsb pdb:6LHD|rcsb pdb:6R5L|rcsb pdb:6RJZ|rcsb pdb:6RK8|rcsb pdb:6RKI|rcsb pdb:6RKK|rcsb pdb:6RKM|rcsb pdb:6RL3|rcsb pdb:6RL4|rcsb pdb:6RL6|rcsb pdb:6RM5|rcsb pdb:6RM7|rcsb pdb:6RWH|rcsb pdb:6RWI|rcsb pdb:6RWS|rcsb pdb:6RWU|rcsb pdb:6RX2|rcsb pdb:6RZ3|rcsb pdb:6S39|rcsb pdb:6S40|rcsb pdb:6S9Q|rcsb pdb:6SHZ|rcsb pdb:6SI0|rcsb pdb:6SI1|rcsb pdb:6SI2|rcsb pdb:6SI3|rcsb pdb:6SI4|rcsb pdb:6SIN|rcsb pdb:6SIO|rcsb pdb:6SIP|rcsb pdb:6SIQ|rcsb pdb:6SL6|rcsb pdb:6SLV|rcsb pdb:6T58|rcsb pdb:6V4F|rcsb pdb:6V4H|rcsb pdb:6VQO|rcsb pdb:6VR1|rcsb pdb:6VR5|rcsb pdb:6VRM|rcsb pdb:6VRN|rcsb pdb:6W51|rcsb pdb:6S3C|ensembl:ENSP00000269305|ensembl:ENST00000420246|ensembl:ENSP00000391127|ensembl:ENSP00000391478|ensembl:ENST00000455263|ensembl:ENSP00000398846|ensembl:ENST00000504290|ensembl:ENSP00000484409|ensembl:ENST00000504937|ensembl:ENSP00000481179|ensembl:ENST00000510385|ensembl:ENSP00000478499|ensembl:ENST00000610292|ensembl:ENSP00000478219|ensembl:ENST00000610538|ensembl:ENSP00000480868|ensembl:ENST00000619485|ensembl:ENSP00000482537|ensembl:ENST00000620739|ensembl:ENSP00000481638|ensembl:ENST00000622645|ensembl:ENSP00000482222|refseq:NP_001119590.1|refseq:NP_001263626.1|refseq:NP_001263627.1|refseq:NP_001263628.1|refseq:NP_001263689.1|refseq:NP_001263690.1|dip:DIP-368N	refseq:NP_001273501.1|refseq:NP_001193962.1|refseq:NP_001193963.1|refseq:NP_055586.1|go:"GO:1900364"(negative regulation of mRNA polyadenylation)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902916"(positive regulation of protein polyubiquitination)|go:"GO:2001168"(positive regulation of histone H2B ubiquitination)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013956(E3 ubiquitin ligase, BRE1)|interpro:IPR017907|mint:O75150|reactome:R-HSA-8866654|go:"GO:0046872"(metal ion binding)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043679"(axon terminus)|go:"GO:0044877"(protein-containing complex binding)|ensembl:ENSG00000103549(gene)|ensembl:ENST00000324685(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0016020"(membrane)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033503"(HULC complex)	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supp. Fig. 10|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/06/01	2018/09/18	rogid:fGN3kSCGIpi/D6d/X5kaB0Xu8/k9606	rogid:POkQZhEBe4cw3Y9V3YOwJDgvYJ89606	intact-crc:027DD2F1B9FF207D|rigid:ojZPyEd6UtEcgnb40ZuYyaHDR+E	false	glutathione s tranferase tag:?-?|sufficient binding region:300-393	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P04637	uniprotkb:Q5VTR2	intact:EBI-366083|uniprotkb:Q15086|uniprotkb:Q15087|uniprotkb:Q15088|uniprotkb:Q16535|uniprotkb:Q16807|uniprotkb:Q16808|uniprotkb:Q16809|uniprotkb:Q16810|uniprotkb:Q16811|uniprotkb:Q16848|uniprotkb:Q86UG1|uniprotkb:Q8J016|uniprotkb:Q99659|uniprotkb:Q9BTM4|uniprotkb:Q9HAQ8|uniprotkb:Q9NP68|uniprotkb:Q9NPJ2|uniprotkb:Q9NZD0|uniprotkb:Q9UBI2|uniprotkb:Q9UQ61|ensembl:ENSP00000269305|ensembl:ENSP00000391478|intact:EBI-28980681|uniprotkb:Q2XN98|uniprotkb:Q3LRW1|uniprotkb:Q3LRW2|uniprotkb:Q3LRW3|uniprotkb:Q3LRW4|uniprotkb:Q3LRW5	intact:EBI-2372238|uniprotkb:Q2TB34|uniprotkb:Q69YL5|uniprotkb:Q6P527|uniprotkb:Q8N3J4|uniprotkb:Q96JD3|uniprotkb:Q9H9Y7|uniprotkb:Q9HA51|uniprotkb:Q9NUR4|uniprotkb:Q9NWQ3|uniprotkb:Q9NX83|uniprotkb:A7MCT5|ensembl:ENSP00000373772	psi-mi:p53_human(display_long)|uniprotkb:TP53(gene name)|psi-mi:TP53(display_short)|uniprotkb:P53(gene name synonym)|uniprotkb:Tumor suppressor p53(gene name synonym)|uniprotkb:Phosphoprotein p53(gene name synonym)|uniprotkb:Antigen NY-CO-13(gene name synonym)	psi-mi:bre1a_human(display_long)|uniprotkb:RNF20(gene name)|psi-mi:RNF20(display_short)|uniprotkb:BRE1A(gene name synonym)|uniprotkb:RING finger protein 20(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BRE1A(gene name synonym)	psi-mi:"MI:0096"(pull down)	Kim et al. (2009)	imex:IM-12178|pubmed:19410543	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2411186|imex:IM-12178-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001263624.1|refseq:NP_001263625.1|ensembl:ENSG00000141510(gene)|ensembl:ENST00000269305(transcript)|ensembl:ENST00000445888(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0001094"(TFIID-class transcription factor complex binding)|go:"GO:0001216"(DNA-binding transcription activator activity)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001756"(somitogenesis)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0002020"(protease binding)|go:"GO:0002039"(p53 binding)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002309"(T cell proliferation involved in immune response)|go:"GO:0002360"(T cell lineage commitment)|go:"GO:0002326"(B cell lineage commitment)|go:"GO:0031497"(chromatin assembly)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034103"(regulation of tissue remodeling)|go:"GO:0034613"(cellular protein localization)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035033"(histone deacetylase regulator activity)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035690"|go:"GO:0035794"(positive regulation of mitochondrial membrane permeability)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036003"(positive regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0036310"(ATP-dependent DNA/DNA annealing activity)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0002931"(response to ischemia)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006914"(autophagy)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006977"(DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)|go:"GO:0006978"(DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator)|go:"GO:0006983"(ER overload response)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007369"(gastrulation)|go:"GO:0007406"(negative regulation of neuroblast proliferation)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0043504"(mitochondrial DNA repair)|go:"GO:0043516"(regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0043621"(protein self-association)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045899"(positive regulation of RNA polymerase II transcription preinitiation complex assembly)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0048512"(circadian behavior)|go:"GO:0048539"(bone marrow development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051097"(negative regulation of helicase activity)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0062100"(positive regulation of programmed necrotic cell death)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0060411"(cardiac septum morphogenesis)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070245"(positive regulation of thymocyte apoptotic process)|go:"GO:0070266"(necroptotic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0071494"(cellular response to UV-C)|go:"GO:0072331"(signal transduction by p53 class mediator)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0072717"(cellular response to actinomycin D)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0090343"(positive regulation of cell aging)|go:"GO:0090399"(replicative senescence)|go:"GO:0090403"(oxidative stress-induced premature senescence)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0097252"(oligodendrocyte apoptotic process)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0140296"(general transcription initiation factor binding)|go:"GO:1900119"(positive regulation of execution phase of apoptosis)|go:"GO:1901525"(negative regulation of mitophagy)|go:"GO:1902108"(regulation of mitochondrial membrane permeability involved in apoptotic process)|go:"GO:1902253"(regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904024"(negative regulation of glucose catabolic process to lactate via pyruvate)|go:"GO:1905856"(negative regulation of pentose-phosphate shunt)|go:"GO:1990144"(intrinsic apoptotic signaling pathway in response to hypoxia)|go:"GO:1990248"(regulation of transcription from RNA polymerase II promoter in response to DNA damage)|go:"GO:1990440"(positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000269"(regulation of fibroblast apoptotic process)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000772"(regulation of cellular senescence)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002117(p53 tumor antigen)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR010991(p53, tetramerisation)|interpro:IPR011615(p53, DNA-binding)|go:"GO:0007569"(cell aging)|go:"GO:0008104"(protein localization)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008156"(negative regulation of DNA replication)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009299"(mRNA transcription)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009651"(response to salt stress)|go:"GO:0010165"(response to X-ray)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0016032"(viral process)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016605"(PML body)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031065"(positive regulation of histone deacetylation)|interpro:IPR012346(p53 and RUNT-type transcription factor, DNA-binding)|interpro:IPR013872("p53 transactivation domain (TAD)")|interpro:IPR036674|interpro:IPR040926|rcsb pdb:2ATA|rcsb pdb:2B3G|rcsb pdb:2BIM|rcsb pdb:2BIN|rcsb pdb:2BIO|rcsb pdb:2BIP|rcsb pdb:2AHI|rcsb pdb:2BIQ|rcsb pdb:2F1X|rcsb pdb:2FEJ|rcsb pdb:2FOJ|rcsb pdb:2FOO|rcsb pdb:2GS0|rcsb pdb:2H1L|rcsb pdb:2H2D|rcsb pdb:2H2F|rcsb pdb:2H4F|rcsb pdb:2H4H|rcsb pdb:2H4J|rcsb pdb:2H59|rcsb pdb:2J0Z|rcsb pdb:2J10|rcsb pdb:2J11|rcsb pdb:2J1W|rcsb pdb:2J1X|rcsb pdb:2J1Y|rcsb pdb:2J1Z|rcsb pdb:2J20|rcsb pdb:2J21|rcsb pdb:2K8F|rcsb pdb:2L14|rcsb pdb:2LY4|rcsb pdb:2MEJ|rcsb pdb:2MWO|rcsb pdb:2MWP|rcsb pdb:2MWY|rcsb pdb:2MZD|rcsb pdb:2OCJ|rcsb pdb:2PCX|rcsb pdb:1A1U|rcsb pdb:1AIE|rcsb pdb:1C26|rcsb pdb:1DT7|rcsb pdb:1GZH|rcsb pdb:1H26|rcsb pdb:1HS5|rcsb pdb:1JSP|rcsb pdb:1KZY|rcsb pdb:1MA3|rcsb pdb:1OLG|rcsb pdb:1OLH|rcsb pdb:1PES|rcsb pdb:1PET|mint:P04637|rcsb pdb:1SAE|rcsb pdb:1SAF|rcsb pdb:1SAK|rcsb pdb:1SAL|rcsb pdb:1TSR|rcsb pdb:1TUP|rcsb pdb:1UOL|rcsb pdb:1XQH|rcsb pdb:1YC5|rcsb pdb:1YCQ|rcsb pdb:1YCR|rcsb pdb:1YCS|rcsb pdb:2AC0|rcsb pdb:2ADY|refseq:NP_000537.3|refseq:NP_001119584.1|refseq:NP_001119585.1|refseq:NP_001119586.1|refseq:NP_001119587.1|refseq:NP_001119588.1|refseq:NP_001119589.1|rcsb pdb:2RUK|rcsb pdb:2VUK|rcsb pdb:3Q06|rcsb pdb:2WGX|rcsb pdb:2X0U|rcsb pdb:2X0V|rcsb pdb:2X0W|rcsb pdb:2XWR|rcsb pdb:2YBG|rcsb pdb:2YDR|rcsb pdb:2Z5S|rcsb pdb:2Z5T|rcsb pdb:3SAK|rcsb pdb:3D05|rcsb pdb:3D06|rcsb pdb:3D07|rcsb pdb:3D08|rcsb pdb:3D09|rcsb pdb:3D0A|rcsb pdb:3DAB|rcsb pdb:3DAC|rcsb pdb:3IGK|rcsb pdb:3IGL|rcsb pdb:3KMD|rcsb pdb:3TG5|rcsb pdb:3KZ8|rcsb pdb:3LW1|rcsb pdb:3OQ5|rcsb pdb:3PDH|rcsb pdb:3Q01|rcsb pdb:3Q05|rcsb pdb:3TS8|rcsb pdb:3ZME|rcsb pdb:4AGM|rcsb pdb:4AGN|rcsb pdb:4AGO|rcsb pdb:4AGP|rcsb pdb:4AGQ|rcsb pdb:4BUZ|rcsb pdb:4BV2|rcsb pdb:4HFZ|rcsb pdb:4HJE|rcsb pdb:4IBQ|rcsb pdb:4IBS|rcsb pdb:4IBT|rcsb pdb:4IBU|rcsb pdb:4IBV|rcsb pdb:4IBW|rcsb pdb:4IBY|rcsb pdb:4IBZ|rcsb pdb:4IJT|rcsb pdb:4KVP|rcsb pdb:4LO9|rcsb pdb:4LOE|rcsb pdb:4LOF|rcsb pdb:4MZI|rcsb pdb:4MZR|rcsb pdb:4QO1|rcsb pdb:4RP6|rcsb pdb:4RP7|rcsb pdb:4X34|rcsb pdb:4XR8|rcsb pdb:4ZZJ|rcsb pdb:5A7B|rcsb pdb:5AB9|rcsb pdb:5ABA|rcsb pdb:4AGL|rcsb pdb:5AOI|rcsb pdb:5AOJ|rcsb pdb:5AOK|rcsb pdb:5AOL|rcsb pdb:5AOM|rcsb pdb:6XRE|rcsb pdb:7BWN|rcsb pdb:7DHY|rcsb pdb:7DHZ|rcsb pdb:7EL4|reactome:R-HSA-111448|reactome:R-HSA-139915|reactome:R-HSA-1912408|reactome:R-HSA-2559580|reactome:R-HSA-2559584|reactome:R-HSA-2559585|reactome:R-HSA-2559586|reactome:R-HSA-3232118|reactome:R-HSA-349425|reactome:R-HSA-390471|reactome:R-HSA-5620971|reactome:R-HSA-5628897|reactome:R-HSA-5689880|reactome:R-HSA-5689896|reactome:R-HSA-5693565|reactome:R-HSA-6785807|reactome:R-HSA-6796648|reactome:R-HSA-6803204|reactome:R-HSA-6803205|reactome:R-HSA-6803207|reactome:R-HSA-6803211|reactome:R-HSA-6804114|reactome:R-HSA-6804115|reactome:R-HSA-6804116|reactome:R-HSA-6804754|reactome:R-HSA-6804756|reactome:R-HSA-6804757|reactome:R-HSA-6804758|reactome:R-HSA-6804759|reactome:R-HSA-6804760|reactome:R-HSA-6811555|reactome:R-HSA-69473|reactome:R-HSA-69481|reactome:R-HSA-69541|reactome:R-HSA-69895|reactome:R-HSA-8852276|reactome:R-HSA-8853884|reactome:R-HSA-8941855|reactome:R-HSA-8943724|reactome:R-HSA-983231|rcsb pdb:5ECG|rcsb pdb:5G4M|rcsb pdb:5G4N|rcsb pdb:5BUA|rcsb pdb:5G4O|rcsb pdb:5HOU|rcsb pdb:5HP0|rcsb pdb:5HPD|rcsb pdb:5LAP|rcsb pdb:5LGY|rcsb pdb:5MCT|rcsb pdb:5MCU|rcsb pdb:5MCV|rcsb pdb:5MCW|rcsb pdb:5MF7|rcsb pdb:5MG7|rcsb pdb:5MHC|rcsb pdb:5MOC|rcsb pdb:5O1A|rcsb pdb:5O1B|rcsb pdb:5O1C|rcsb pdb:5O1D|rcsb pdb:5O1E|rcsb pdb:5O1F|rcsb pdb:5O1G|rcsb pdb:5O1H|rcsb pdb:5O1I|rcsb pdb:5OL0|rcsb pdb:5UN8|rcsb pdb:5XZC|rcsb pdb:6FF9|rcsb pdb:6FJ5|rcsb pdb:6GGA|rcsb pdb:6GGB|rcsb pdb:6GGC|rcsb pdb:6GGD|rcsb pdb:6GGE|rcsb pdb:6GGF|rcsb pdb:6LHD|rcsb pdb:6R5L|rcsb pdb:6RJZ|rcsb pdb:6RK8|rcsb pdb:6RKI|rcsb pdb:6RKK|rcsb pdb:6RKM|rcsb pdb:6RL3|rcsb pdb:6RL4|rcsb pdb:6RL6|rcsb pdb:6RM5|rcsb pdb:6RM7|rcsb pdb:6RWH|rcsb pdb:6RWI|rcsb pdb:6RWS|rcsb pdb:6RWU|rcsb pdb:6RX2|rcsb pdb:6RZ3|rcsb pdb:6S39|rcsb pdb:6S40|rcsb pdb:6S9Q|rcsb pdb:6SHZ|rcsb pdb:6SI0|rcsb pdb:6SI1|rcsb pdb:6SI2|rcsb pdb:6SI3|rcsb pdb:6SI4|rcsb pdb:6SIN|rcsb pdb:6SIO|rcsb pdb:6SIP|rcsb pdb:6SIQ|rcsb pdb:6SL6|rcsb pdb:6SLV|rcsb pdb:6T58|rcsb pdb:6V4F|rcsb pdb:6V4H|rcsb pdb:6VQO|rcsb pdb:6VR1|rcsb pdb:6VR5|rcsb pdb:6VRM|rcsb pdb:6VRN|rcsb pdb:6W51|rcsb pdb:6S3C|ensembl:ENSP00000269305|ensembl:ENST00000420246|ensembl:ENSP00000391127|ensembl:ENSP00000391478|ensembl:ENST00000455263|ensembl:ENSP00000398846|ensembl:ENST00000504290|ensembl:ENSP00000484409|ensembl:ENST00000504937|ensembl:ENSP00000481179|ensembl:ENST00000510385|ensembl:ENSP00000478499|ensembl:ENST00000610292|ensembl:ENSP00000478219|ensembl:ENST00000610538|ensembl:ENSP00000480868|ensembl:ENST00000619485|ensembl:ENSP00000482537|ensembl:ENST00000620739|ensembl:ENSP00000481638|ensembl:ENST00000622645|ensembl:ENSP00000482222|refseq:NP_001119590.1|refseq:NP_001263626.1|refseq:NP_001263627.1|refseq:NP_001263628.1|refseq:NP_001263689.1|refseq:NP_001263690.1|dip:DIP-368N	refseq:XP_011517164.1|refseq:NP_062538.5|dip:DIP-53411N|ensembl:ENSG00000155827(gene)|ensembl:ENST00000389120(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002039"(p53 binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0031062"(positive regulation of histone methylation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033503"(HULC complex)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0042393"(histone binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:1900364"(negative regulation of mRNA polyadenylation)|go:"GO:2001168"(positive regulation of histone H2B ubiquitination)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013956(E3 ubiquitin ligase, BRE1)|interpro:IPR017907|mint:Q5VTR2|rcsb pdb:5TRB|reactome:R-HSA-8866654|reactome:R-HSA-9013422	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supp. Fig. 10|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/06/01	2018/09/18	rogid:fGN3kSCGIpi/D6d/X5kaB0Xu8/k9606	rogid:zscBhEtpu0D69sPn1wXsEGBIiOY9606	intact-crc:027DD2F1B9FF207D|rigid:ojZPyEd6UtEcgnb40ZuYyaHDR+E	false	glutathione s tranferase tag:?-?|sufficient binding region:300-393	flag tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q5VTR2	uniprotkb:O75150	intact:EBI-2372238|uniprotkb:Q2TB34|uniprotkb:Q69YL5|uniprotkb:Q6P527|uniprotkb:Q8N3J4|uniprotkb:Q96JD3|uniprotkb:Q9H9Y7|uniprotkb:Q9HA51|uniprotkb:Q9NUR4|uniprotkb:Q9NWQ3|uniprotkb:Q9NX83|uniprotkb:A7MCT5|ensembl:ENSP00000373772	intact:EBI-744408|uniprotkb:Q6AHZ6|uniprotkb:Q6N005|uniprotkb:Q7L3T6|uniprotkb:Q8N615|uniprotkb:Q96T18|uniprotkb:Q9BSV9|uniprotkb:Q9HC82|ensembl:ENSP00000325677|uniprotkb:A0A024QZG0	psi-mi:bre1a_human(display_long)|uniprotkb:RNF20(gene name)|psi-mi:RNF20(display_short)|uniprotkb:BRE1A(gene name synonym)|uniprotkb:RING finger protein 20(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BRE1A(gene name synonym)	psi-mi:bre1b_human(display_long)|uniprotkb:95 kDa retinoblastoma-associated protein(gene name synonym)|uniprotkb:RING finger protein 40(gene name synonym)|uniprotkb:RNF40(gene name)|psi-mi:RNF40(display_short)|uniprotkb:BRE1B(gene name synonym)|uniprotkb:KIAA0661(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BRE1B(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kim et al. (2009)	imex:IM-12178|pubmed:19410543	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2410860|imex:IM-12178-14	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011517164.1|refseq:NP_062538.5|dip:DIP-53411N|ensembl:ENSG00000155827(gene)|ensembl:ENST00000389120(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002039"(p53 binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0031062"(positive regulation of histone methylation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033503"(HULC complex)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0042393"(histone binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:1900364"(negative regulation of mRNA polyadenylation)|go:"GO:2001168"(positive regulation of histone H2B ubiquitination)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013956(E3 ubiquitin ligase, BRE1)|interpro:IPR017907|mint:Q5VTR2|rcsb pdb:5TRB|reactome:R-HSA-8866654|reactome:R-HSA-9013422	refseq:NP_001273501.1|refseq:NP_001193962.1|refseq:NP_001193963.1|refseq:NP_055586.1|go:"GO:1900364"(negative regulation of mRNA polyadenylation)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902916"(positive regulation of protein polyubiquitination)|go:"GO:2001168"(positive regulation of histone H2B ubiquitination)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013956(E3 ubiquitin ligase, BRE1)|interpro:IPR017907|mint:O75150|reactome:R-HSA-8866654|go:"GO:0046872"(metal ion binding)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043679"(axon terminus)|go:"GO:0044877"(protein-containing complex binding)|ensembl:ENSG00000103549(gene)|ensembl:ENST00000324685(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0016020"(membrane)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033503"(HULC complex)	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 3C|comment:Western bots also showed Rad6 t be bound to the complex but the antibody did not differentiate between RAD6A and RAD6B.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2009/06/01	2018/09/18	rogid:zscBhEtpu0D69sPn1wXsEGBIiOY9606	rogid:POkQZhEBe4cw3Y9V3YOwJDgvYJ89606	intact-crc:23DC6169DE27D7C7|rigid:gq5a660ZKl+dvAJFWaW5PB01GdY	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q5VTR2	uniprotkb:O75150	intact:EBI-2372238|uniprotkb:Q2TB34|uniprotkb:Q69YL5|uniprotkb:Q6P527|uniprotkb:Q8N3J4|uniprotkb:Q96JD3|uniprotkb:Q9H9Y7|uniprotkb:Q9HA51|uniprotkb:Q9NUR4|uniprotkb:Q9NWQ3|uniprotkb:Q9NX83|uniprotkb:A7MCT5|ensembl:ENSP00000373772	intact:EBI-744408|uniprotkb:Q6AHZ6|uniprotkb:Q6N005|uniprotkb:Q7L3T6|uniprotkb:Q8N615|uniprotkb:Q96T18|uniprotkb:Q9BSV9|uniprotkb:Q9HC82|ensembl:ENSP00000325677|uniprotkb:A0A024QZG0	psi-mi:bre1a_human(display_long)|uniprotkb:RNF20(gene name)|psi-mi:RNF20(display_short)|uniprotkb:BRE1A(gene name synonym)|uniprotkb:RING finger protein 20(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BRE1A(gene name synonym)	psi-mi:bre1b_human(display_long)|uniprotkb:95 kDa retinoblastoma-associated protein(gene name synonym)|uniprotkb:RING finger protein 40(gene name synonym)|uniprotkb:RNF40(gene name)|psi-mi:RNF40(display_short)|uniprotkb:BRE1B(gene name synonym)|uniprotkb:KIAA0661(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BRE1B(gene name synonym)	psi-mi:"MI:0415"(enzymatic study)	Kim et al. (2009)	imex:IM-12178|pubmed:19410543	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2410875|imex:IM-12178-12	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011517164.1|refseq:NP_062538.5|dip:DIP-53411N|ensembl:ENSG00000155827(gene)|ensembl:ENST00000389120(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002039"(p53 binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0031062"(positive regulation of histone methylation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033503"(HULC complex)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0042393"(histone binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:1900364"(negative regulation of mRNA polyadenylation)|go:"GO:2001168"(positive regulation of histone H2B ubiquitination)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013956(E3 ubiquitin ligase, BRE1)|interpro:IPR017907|mint:Q5VTR2|rcsb pdb:5TRB|reactome:R-HSA-8866654|reactome:R-HSA-9013422	refseq:NP_001273501.1|refseq:NP_001193962.1|refseq:NP_001193963.1|refseq:NP_055586.1|go:"GO:1900364"(negative regulation of mRNA polyadenylation)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902916"(positive regulation of protein polyubiquitination)|go:"GO:2001168"(positive regulation of histone H2B ubiquitination)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013956(E3 ubiquitin ligase, BRE1)|interpro:IPR017907|mint:O75150|reactome:R-HSA-8866654|go:"GO:0046872"(metal ion binding)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043679"(axon terminus)|go:"GO:0044877"(protein-containing complex binding)|ensembl:ENSG00000103549(gene)|ensembl:ENST00000324685(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0016020"(membrane)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033503"(HULC complex)	go:"GO:0004842"(ubiquitin-protein transferase activity)	-	-	figure legend:Fig. 3D, Supp. Fig. 5|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/06/01	2018/09/18	rogid:zscBhEtpu0D69sPn1wXsEGBIiOY9606	rogid:POkQZhEBe4cw3Y9V3YOwJDgvYJ89606	intact-crc:4B20D734F0730473|rigid:l6Y/2f3+7jyWkiM4Qs6kjc41S1Y	false	flag tag:?-?	-	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q5VTR2	uniprotkb:P22314	intact:EBI-2372238|uniprotkb:Q2TB34|uniprotkb:Q69YL5|uniprotkb:Q6P527|uniprotkb:Q8N3J4|uniprotkb:Q96JD3|uniprotkb:Q9H9Y7|uniprotkb:Q9HA51|uniprotkb:Q9NUR4|uniprotkb:Q9NWQ3|uniprotkb:Q9NX83|uniprotkb:A7MCT5|ensembl:ENSP00000373772	intact:EBI-709688|uniprotkb:Q96E13|uniprotkb:Q5JRR8|ensembl:ENSP00000338413|ensembl:ENSP00000366568	psi-mi:bre1a_human(display_long)|uniprotkb:RNF20(gene name)|psi-mi:RNF20(display_short)|uniprotkb:BRE1A(gene name synonym)|uniprotkb:RING finger protein 20(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BRE1A(gene name synonym)	psi-mi:uba1_human(display_long)|uniprotkb:Ubiquitin-activating enzyme E1(gene name synonym)|uniprotkb:Protein A1S9(gene name synonym)|uniprotkb:UBA1(gene name)|psi-mi:UBA1(display_short)|uniprotkb:A1S9T(gene name synonym)|uniprotkb:UBE1(gene name synonym)	psi-mi:"MI:0415"(enzymatic study)	Kim et al. (2009)	imex:IM-12178|pubmed:19410543	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2410875|imex:IM-12178-12	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011517164.1|refseq:NP_062538.5|dip:DIP-53411N|ensembl:ENSG00000155827(gene)|ensembl:ENST00000389120(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002039"(p53 binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0031062"(positive regulation of histone methylation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033503"(HULC complex)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0042393"(histone binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:1900364"(negative regulation of mRNA polyadenylation)|go:"GO:2001168"(positive regulation of histone H2B ubiquitination)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013956(E3 ubiquitin ligase, BRE1)|interpro:IPR017907|mint:Q5VTR2|rcsb pdb:5TRB|reactome:R-HSA-8866654|reactome:R-HSA-9013422	refseq:NP_003325.2|refseq:NP_695012.1|refseq:XP_016885269.1|refseq:XP_016885270.1|dip:DIP-33686N|ensembl:ENSG00000130985(gene)|ensembl:ENST00000335972(transcript)|ensembl:ENST00000377351(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004839"(ubiquitin activating enzyme activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000011(Ubiquitin-activating enzyme, E1)|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR018074|interpro:IPR018075|interpro:IPR018965|interpro:IPR019572|interpro:IPR032418|interpro:IPR032420|interpro:IPR033127|interpro:IPR035985|interpro:IPR038252|interpro:IPR042063|interpro:IPR042302|interpro:IPR042449|mint:P22314|rcsb pdb:4P22|rcsb pdb:6DC6|reactome:R-HSA-8866652|reactome:R-HSA-983168	go:"GO:0004842"(ubiquitin-protein transferase activity)	-	-	figure legend:Fig. 3D, Supp. Fig. 5|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/06/01	2018/09/18	rogid:zscBhEtpu0D69sPn1wXsEGBIiOY9606	rogid:q+vEeA0XLST0Zz173bmEt0dNbDE9606	intact-crc:4B20D734F0730473|rigid:l6Y/2f3+7jyWkiM4Qs6kjc41S1Y	false	flag tag:?-?	-	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q5VTR2	uniprotkb:P0CG47	intact:EBI-2372238|uniprotkb:Q2TB34|uniprotkb:Q69YL5|uniprotkb:Q6P527|uniprotkb:Q8N3J4|uniprotkb:Q96JD3|uniprotkb:Q9H9Y7|uniprotkb:Q9HA51|uniprotkb:Q9NUR4|uniprotkb:Q9NWQ3|uniprotkb:Q9NX83|uniprotkb:A7MCT5|ensembl:ENSP00000373772	intact:EBI-413034|uniprotkb:P02248|uniprotkb:P02249|uniprotkb:P02250|uniprotkb:Q29120|uniprotkb:Q6LBL4|uniprotkb:Q6LDU5|uniprotkb:Q8WYN8|uniprotkb:Q91887|uniprotkb:Q91888|uniprotkb:Q9BWD6|uniprotkb:Q9BX98|uniprotkb:Q9UEF2|uniprotkb:Q9UEG1|uniprotkb:Q9UEK8|uniprotkb:Q9UPK7|uniprotkb:P62988|ensembl:ENSP00000304697|ensembl:ENSP00000379178|ensembl:ENSP00000379180|ensembl:ENSP00000478771	psi-mi:bre1a_human(display_long)|uniprotkb:RNF20(gene name)|psi-mi:RNF20(display_short)|uniprotkb:BRE1A(gene name synonym)|uniprotkb:RING finger protein 20(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BRE1A(gene name synonym)	psi-mi:ubb_human(display_long)|uniprotkb:UBB(gene name)|psi-mi:UBB(display_short)	psi-mi:"MI:0415"(enzymatic study)	Kim et al. (2009)	imex:IM-12178|pubmed:19410543	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2410875|imex:IM-12178-12	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011517164.1|refseq:NP_062538.5|dip:DIP-53411N|ensembl:ENSG00000155827(gene)|ensembl:ENST00000389120(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002039"(p53 binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0031062"(positive regulation of histone methylation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033503"(HULC complex)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0042393"(histone binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:1900364"(negative regulation of mRNA polyadenylation)|go:"GO:2001168"(positive regulation of histone H2B ubiquitination)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013956(E3 ubiquitin ligase, BRE1)|interpro:IPR017907|mint:Q5VTR2|rcsb pdb:5TRB|reactome:R-HSA-8866654|reactome:R-HSA-9013422	refseq:NP_061828.1|refseq:NP_001268645.1|refseq:NP_001268646.1|refseq:NP_001268647.1|refseq:NP_001268648.1|refseq:NP_001268649.1|interpro:IPR019954|interpro:IPR019956|interpro:IPR029071|mint:P0CG47|go:"GO:0047497"(mitochondrion transport along microtubule)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0060613"(fat pad development)|rcsb pdb:2KHW|rcsb pdb:2MBB|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070062"(extracellular exosome)|rcsb pdb:2MRO|go:"GO:0072520"(seminiferous tubule development)|go:"GO:0097009"(energy homeostasis)|rcsb pdb:2MSG|go:"GO:1901214"(regulation of neuron death)|rcsb pdb:2N13|rcsb pdb:4UEL|rcsb pdb:4UF6|rcsb pdb:4WHV|rcsb pdb:4WLR|rcsb pdb:4WUR|rcsb pdb:4XOF|rcsb pdb:4ZFR|rcsb pdb:4ZFT|go:"GO:1902255"(positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1902527"(positive regulation of protein monoubiquitination)|rcsb pdb:4ZPZ|rcsb pdb:4ZUX|rcsb pdb:5BNB|rcsb pdb:5CAW|rcsb pdb:5CRA|rcsb pdb:5CVM|rcsb pdb:5CVN|rcsb pdb:5CVO|interpro:IPR000626(Ubiquitin)|rcsb pdb:5D0K|rcsb pdb:5D0M|rcsb pdb:5DFL|rcsb pdb:5DK8|rcsb pdb:5E6J|rcsb pdb:5EDV|rcsb pdb:5EMZ|rcsb pdb:5EYA|rcsb pdb:5GJQ|rcsb pdb:5GO7|rcsb pdb:5GO8|rcsb pdb:5GOB|rcsb pdb:5GOC|rcsb pdb:5GOD|rcsb pdb:5GOG|rcsb pdb:5GOH|rcsb pdb:5GOI|rcsb pdb:5GOJ|rcsb pdb:5GOK|rcsb pdb:5H7S|rcsb pdb:5IBK|rcsb pdb:5IFR|rcsb pdb:5JBY|rcsb pdb:5JG6|rcsb pdb:5JP3|rcsb pdb:5JTJ|rcsb pdb:5JTV|rcsb pdb:5K9P|rcsb pdb:5KGF|rcsb pdb:5KHY|rcsb pdb:5KYC|rcsb pdb:5KYD|rcsb pdb:5KYE|rcsb pdb:5KYF|rcsb pdb:5L8H|rcsb pdb:5L8W|rcsb pdb:5L9T|rcsb pdb:5LN1|rcsb pdb:5LRV|rcsb pdb:5LRW|rcsb pdb:5LRX|rcsb pdb:5M93|rcsb pdb:5MNJ|rcsb pdb:5N2W|rcsb pdb:5N38|rcsb pdb:5NL5|rcsb pdb:5NLJ|rcsb pdb:5NVG|rcsb pdb:5O44|rcsb pdb:5O6T|rcsb pdb:5OHK|rcsb pdb:5OHL|rcsb pdb:5OHN|rcsb pdb:5OHP|rcsb pdb:5TOF|rcsb pdb:5TOG|rcsb pdb:5TUT|rcsb pdb:5TXK|rcsb pdb:5UJL|rcsb pdb:5UJN|rcsb pdb:5ULF|rcsb pdb:5ULH|rcsb pdb:5ULK|rcsb pdb:5V1Y|rcsb pdb:5V1Z|rcsb pdb:5VEY|rcsb pdb:5VF0|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5VZM|rcsb pdb:5VZW|rcsb pdb:5W46|rcsb pdb:5WFI|rcsb pdb:5X3M|rcsb pdb:5X3N|rcsb pdb:5X3O|rcsb pdb:5XBO|rcsb pdb:5XDP|rcsb pdb:5XK4|rcsb pdb:5XK5|rcsb pdb:5XPK|rcsb pdb:5YDR|rcsb pdb:5YIJ|rcsb pdb:5YIK|rcsb pdb:5YMY|rcsb pdb:5YT6|rcsb pdb:5ZBU|rcsb pdb:5ZD0|rcsb pdb:6ASR|rcsb pdb:6BVA|rcsb pdb:6BYH|rcsb pdb:6C16|rcsb pdb:6CP2|rcsb pdb:6DGF|rcsb pdb:6EI1|rcsb pdb:6FDK|rcsb pdb:6FGE|rcsb pdb:6FTX|rcsb pdb:6FX4|rcsb pdb:6FYH|rcsb pdb:6GLC|rcsb pdb:6GZS|rcsb pdb:6H4H|rcsb pdb:6HEI|rcsb pdb:6HEK|rcsb pdb:6IF1|rcsb pdb:6ISU|rcsb pdb:6JB6|rcsb pdb:6JB7|rcsb pdb:6JMA|rcsb pdb:6K4I|rcsb pdb:6K9P|rcsb pdb:6KOW|rcsb pdb:6KOX|rcsb pdb:6LP2|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6N13|rcsb pdb:6NJ9|rcsb pdb:6NJG|rcsb pdb:6O96|rcsb pdb:6OAM|rcsb pdb:6PGV|rcsb pdb:6PZV|rcsb pdb:6QF8|rcsb pdb:6QK9|rcsb pdb:6QML|rcsb pdb:6TBM|rcsb pdb:6UH5|rcsb pdb:6XAA|rcsb pdb:7AY2|rcsb pdb:7BBD|rcsb pdb:7CAP|rcsb pdb:7JMS|rcsb pdb:7LYC|reactome:R-HSA-110312|reactome:R-HSA-110314|reactome:R-HSA-110320|reactome:R-HSA-1169091|reactome:R-HSA-1169408|reactome:R-HSA-1234176|reactome:R-HSA-1236382|reactome:R-HSA-1236974|reactome:R-HSA-1253288|reactome:R-HSA-1295596|reactome:R-HSA-1358803|reactome:R-HSA-162588|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-168928|reactome:R-HSA-174048|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174184|reactome:R-HSA-174490|reactome:R-HSA-175474|reactome:R-HSA-179409|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-182971|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-201681|reactome:R-HSA-202424|reactome:R-HSA-205043|reactome:R-HSA-209543|reactome:R-HSA-209560|reactome:R-HSA-211733|reactome:R-HSA-2122947|reactome:R-HSA-2122948|reactome:R-HSA-2173788|reactome:R-HSA-2173791|reactome:R-HSA-174178|reactome:R-HSA-2173795|reactome:R-HSA-2173796|reactome:R-HSA-2467813|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559585|reactome:R-HSA-2565942|reactome:R-HSA-2644606|reactome:R-HSA-2672351|reactome:R-HSA-2691232|reactome:R-HSA-2871837|reactome:R-HSA-2894862|reactome:R-HSA-2979096|reactome:R-HSA-3134975|reactome:R-HSA-3322077|reactome:R-HSA-349425|reactome:R-HSA-3769402|reactome:R-HSA-3785653|reactome:R-HSA-382556|reactome:R-HSA-400253|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-4641263|reactome:R-HSA-5205685|reactome:R-HSA-532668|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5655862|reactome:R-HSA-5656121|reactome:R-HSA-5656169|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5675221|reactome:R-HSA-5675482|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5684264|reactome:R-HSA-5685942|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689877|reactome:R-HSA-5689880|reactome:R-HSA-5689896|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693607|reactome:R-HSA-5696394|reactome:R-HSA-5696395|reactome:R-HSA-5696397|reactome:R-HSA-5696400|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6783310|reactome:R-HSA-6804756|reactome:R-HSA-6804757|reactome:R-HSA-6804760|reactome:R-HSA-6807004|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69231|reactome:R-HSA-69481|reactome:R-HSA-69541|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8849469|reactome:R-HSA-983168|reactome:R-HSA-8852276|reactome:R-HSA-8941858|reactome:R-HSA-8854050|reactome:R-HSA-8856825|reactome:R-HSA-8948747|reactome:R-HSA-8948751|reactome:R-HSA-8856828|reactome:R-HSA-8951664|reactome:R-HSA-8863795|reactome:R-HSA-8866652|reactome:R-HSA-8866654|reactome:R-HSA-8875360|reactome:R-HSA-8876493|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-901032|reactome:R-HSA-9010553|reactome:R-HSA-9013507|reactome:R-HSA-9013973|reactome:R-HSA-9014325|reactome:R-HSA-9020702|reactome:R-HSA-9033241|reactome:R-HSA-912631|reactome:R-HSA-917729|reactome:R-HSA-917937|reactome:R-HSA-936440|reactome:R-HSA-936964|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-937042|reactome:R-HSA-937072|reactome:R-HSA-9604323|reactome:R-HSA-9613829|reactome:R-HSA-9615710|reactome:R-HSA-9636383|reactome:R-HSA-9637628|reactome:R-HSA-9645460|reactome:R-HSA-9646399|reactome:R-HSA-9648002|reactome:R-HSA-9664873|reactome:R-HSA-9683683|reactome:R-HSA-9694493|reactome:R-HSA-9705462|reactome:R-HSA-9706369|reactome:R-HSA-9706377|reactome:R-HSA-9708530|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-975163|reactome:R-HSA-977225|ensembl:ENSG00000170315(gene)|ensembl:ENST00000302182(transcript)|ensembl:ENST00000395837(transcript)|ensembl:ENST00000395839(transcript)|ensembl:ENST00000614404(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007141"(male meiosis I)|go:"GO:0007144"(female meiosis I)|go:"GO:0008585"(female gonad development)|go:"GO:0010008"(endosome membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019941"(modification-dependent protein catabolic process)|go:"GO:0021888"(hypothalamus gonadotrophin-releasing hormone neuron development)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031386"(protein tag)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031982"(vesicle)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)	go:"GO:0004842"(ubiquitin-protein transferase activity)	-	-	figure legend:Fig. 3D, Supp. Fig. 5|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/06/01	2018/09/18	rogid:zscBhEtpu0D69sPn1wXsEGBIiOY9606	rogid:X2Y1hzv2uGZd9FObQD2Qq3SECRo9606	intact-crc:4B20D734F0730473|rigid:l6Y/2f3+7jyWkiM4Qs6kjc41S1Y	false	flag tag:?-?	32p radiolabel:?-?|his tag:?-?|ha tag:?-?	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q5VTR2	uniprotkb:P49459	intact:EBI-2372238|uniprotkb:Q2TB34|uniprotkb:Q69YL5|uniprotkb:Q6P527|uniprotkb:Q8N3J4|uniprotkb:Q96JD3|uniprotkb:Q9H9Y7|uniprotkb:Q9HA51|uniprotkb:Q9NUR4|uniprotkb:Q9NWQ3|uniprotkb:Q9NX83|uniprotkb:A7MCT5|ensembl:ENSP00000373772	intact:EBI-2339348|uniprotkb:A6NMF5|uniprotkb:Q96FX4|uniprotkb:B2R7R9|uniprotkb:Q4TTG1|uniprotkb:D3DWI1|uniprotkb:A6NFE9|uniprotkb:A6NGR2|ensembl:ENSP00000360613	psi-mi:bre1a_human(display_long)|uniprotkb:RNF20(gene name)|psi-mi:RNF20(display_short)|uniprotkb:BRE1A(gene name synonym)|uniprotkb:RING finger protein 20(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BRE1A(gene name synonym)	psi-mi:ube2a_human(display_long)|uniprotkb:UBE2A(gene name)|psi-mi:UBE2A(display_short)|uniprotkb:RAD6A(gene name synonym)|uniprotkb:Ubiquitin-protein ligase A(gene name synonym)|uniprotkb:Ubiquitin carrier protein A(gene name synonym)|uniprotkb:RAD6 homolog A(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme A(gene name synonym)	psi-mi:"MI:0415"(enzymatic study)	Kim et al. (2009)	imex:IM-12178|pubmed:19410543	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2410875|imex:IM-12178-12	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011517164.1|refseq:NP_062538.5|dip:DIP-53411N|ensembl:ENSG00000155827(gene)|ensembl:ENST00000389120(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002039"(p53 binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0031062"(positive regulation of histone methylation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033503"(HULC complex)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0042393"(histone binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:1900364"(negative regulation of mRNA polyadenylation)|go:"GO:2001168"(positive regulation of histone H2B ubiquitination)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013956(E3 ubiquitin ligase, BRE1)|interpro:IPR017907|mint:Q5VTR2|rcsb pdb:5TRB|reactome:R-HSA-8866654|reactome:R-HSA-9013422	refseq:NP_003327.2|refseq:NP_861427.1|refseq:NP_001269090.1|dip:DIP-24260N|ensembl:ENSG00000077721(gene)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000785"(chromatin)|go:"GO:0001741"(XY body)|go:"GO:0001835"(blastocyst hatching)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009411"(response to UV)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033503"(HULC complex)|go:"GO:0033522"(histone H2A ubiquitination)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0060135"(maternal process involved in female pregnancy)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0070979"(protein K11-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|mint:P49459|rcsb pdb:6CYO|rcsb pdb:6CYR|reactome:R-HSA-8866652|reactome:R-HSA-8866654|reactome:R-HSA-983168|ensembl:ENST00000371558(transcript)	go:"GO:0004842"(ubiquitin-protein transferase activity)	-	-	figure legend:Fig. 3D, Supp. Fig. 5|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/06/01	2018/09/18	rogid:zscBhEtpu0D69sPn1wXsEGBIiOY9606	rogid:T6Mzgy6RHO9HoEIG3FmQvsP32vU9606	intact-crc:4B20D734F0730473|rigid:l6Y/2f3+7jyWkiM4Qs6kjc41S1Y	false	flag tag:?-?	mutation:88-88	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q5VTR2	uniprotkb:O75150	intact:EBI-2372238|uniprotkb:Q2TB34|uniprotkb:Q69YL5|uniprotkb:Q6P527|uniprotkb:Q8N3J4|uniprotkb:Q96JD3|uniprotkb:Q9H9Y7|uniprotkb:Q9HA51|uniprotkb:Q9NUR4|uniprotkb:Q9NWQ3|uniprotkb:Q9NX83|uniprotkb:A7MCT5|ensembl:ENSP00000373772	intact:EBI-744408|uniprotkb:Q6AHZ6|uniprotkb:Q6N005|uniprotkb:Q7L3T6|uniprotkb:Q8N615|uniprotkb:Q96T18|uniprotkb:Q9BSV9|uniprotkb:Q9HC82|ensembl:ENSP00000325677|uniprotkb:A0A024QZG0	psi-mi:bre1a_human(display_long)|uniprotkb:RNF20(gene name)|psi-mi:RNF20(display_short)|uniprotkb:BRE1A(gene name synonym)|uniprotkb:RING finger protein 20(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BRE1A(gene name synonym)	psi-mi:bre1b_human(display_long)|uniprotkb:95 kDa retinoblastoma-associated protein(gene name synonym)|uniprotkb:RING finger protein 40(gene name synonym)|uniprotkb:RNF40(gene name)|psi-mi:RNF40(display_short)|uniprotkb:BRE1B(gene name synonym)|uniprotkb:KIAA0661(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BRE1B(gene name synonym)	psi-mi:"MI:0415"(enzymatic study)	Kim et al. (2009)	imex:IM-12178|pubmed:19410543	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2410894|imex:IM-12178-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011517164.1|refseq:NP_062538.5|dip:DIP-53411N|ensembl:ENSG00000155827(gene)|ensembl:ENST00000389120(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002039"(p53 binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0031062"(positive regulation of histone methylation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033503"(HULC complex)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0042393"(histone binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:1900364"(negative regulation of mRNA polyadenylation)|go:"GO:2001168"(positive regulation of histone H2B ubiquitination)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013956(E3 ubiquitin ligase, BRE1)|interpro:IPR017907|mint:Q5VTR2|rcsb pdb:5TRB|reactome:R-HSA-8866654|reactome:R-HSA-9013422	refseq:NP_001273501.1|refseq:NP_001193962.1|refseq:NP_001193963.1|refseq:NP_055586.1|go:"GO:1900364"(negative regulation of mRNA polyadenylation)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902916"(positive regulation of protein polyubiquitination)|go:"GO:2001168"(positive regulation of histone H2B ubiquitination)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013956(E3 ubiquitin ligase, BRE1)|interpro:IPR017907|mint:O75150|reactome:R-HSA-8866654|go:"GO:0046872"(metal ion binding)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043679"(axon terminus)|go:"GO:0044877"(protein-containing complex binding)|ensembl:ENSG00000103549(gene)|ensembl:ENST00000324685(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0016020"(membrane)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033503"(HULC complex)	go:"GO:0004842"(ubiquitin-protein transferase activity)	-	-	figure legend:Fig. 3D, Supp. Fig. 5|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/06/01	2018/09/18	rogid:zscBhEtpu0D69sPn1wXsEGBIiOY9606	rogid:POkQZhEBe4cw3Y9V3YOwJDgvYJ89606	intact-crc:9E9C17459CC1098A|rigid:A75v6lhTVXu6pu2w0qg7NZuxnRU	false	flag tag:?-?	-	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q5VTR2	uniprotkb:P22314	intact:EBI-2372238|uniprotkb:Q2TB34|uniprotkb:Q69YL5|uniprotkb:Q6P527|uniprotkb:Q8N3J4|uniprotkb:Q96JD3|uniprotkb:Q9H9Y7|uniprotkb:Q9HA51|uniprotkb:Q9NUR4|uniprotkb:Q9NWQ3|uniprotkb:Q9NX83|uniprotkb:A7MCT5|ensembl:ENSP00000373772	intact:EBI-709688|uniprotkb:Q96E13|uniprotkb:Q5JRR8|ensembl:ENSP00000338413|ensembl:ENSP00000366568	psi-mi:bre1a_human(display_long)|uniprotkb:RNF20(gene name)|psi-mi:RNF20(display_short)|uniprotkb:BRE1A(gene name synonym)|uniprotkb:RING finger protein 20(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BRE1A(gene name synonym)	psi-mi:uba1_human(display_long)|uniprotkb:Ubiquitin-activating enzyme E1(gene name synonym)|uniprotkb:Protein A1S9(gene name synonym)|uniprotkb:UBA1(gene name)|psi-mi:UBA1(display_short)|uniprotkb:A1S9T(gene name synonym)|uniprotkb:UBE1(gene name synonym)	psi-mi:"MI:0415"(enzymatic study)	Kim et al. (2009)	imex:IM-12178|pubmed:19410543	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2410894|imex:IM-12178-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011517164.1|refseq:NP_062538.5|dip:DIP-53411N|ensembl:ENSG00000155827(gene)|ensembl:ENST00000389120(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002039"(p53 binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0031062"(positive regulation of histone methylation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033503"(HULC complex)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0042393"(histone binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:1900364"(negative regulation of mRNA polyadenylation)|go:"GO:2001168"(positive regulation of histone H2B ubiquitination)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013956(E3 ubiquitin ligase, BRE1)|interpro:IPR017907|mint:Q5VTR2|rcsb pdb:5TRB|reactome:R-HSA-8866654|reactome:R-HSA-9013422	refseq:NP_003325.2|refseq:NP_695012.1|refseq:XP_016885269.1|refseq:XP_016885270.1|dip:DIP-33686N|ensembl:ENSG00000130985(gene)|ensembl:ENST00000335972(transcript)|ensembl:ENST00000377351(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004839"(ubiquitin activating enzyme activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000011(Ubiquitin-activating enzyme, E1)|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR018074|interpro:IPR018075|interpro:IPR018965|interpro:IPR019572|interpro:IPR032418|interpro:IPR032420|interpro:IPR033127|interpro:IPR035985|interpro:IPR038252|interpro:IPR042063|interpro:IPR042302|interpro:IPR042449|mint:P22314|rcsb pdb:4P22|rcsb pdb:6DC6|reactome:R-HSA-8866652|reactome:R-HSA-983168	go:"GO:0004842"(ubiquitin-protein transferase activity)	-	-	figure legend:Fig. 3D, Supp. Fig. 5|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/06/01	2018/09/18	rogid:zscBhEtpu0D69sPn1wXsEGBIiOY9606	rogid:q+vEeA0XLST0Zz173bmEt0dNbDE9606	intact-crc:9E9C17459CC1098A|rigid:A75v6lhTVXu6pu2w0qg7NZuxnRU	false	flag tag:?-?	-	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q5VTR2	uniprotkb:P0CG47	intact:EBI-2372238|uniprotkb:Q2TB34|uniprotkb:Q69YL5|uniprotkb:Q6P527|uniprotkb:Q8N3J4|uniprotkb:Q96JD3|uniprotkb:Q9H9Y7|uniprotkb:Q9HA51|uniprotkb:Q9NUR4|uniprotkb:Q9NWQ3|uniprotkb:Q9NX83|uniprotkb:A7MCT5|ensembl:ENSP00000373772	intact:EBI-413034|uniprotkb:P02248|uniprotkb:P02249|uniprotkb:P02250|uniprotkb:Q29120|uniprotkb:Q6LBL4|uniprotkb:Q6LDU5|uniprotkb:Q8WYN8|uniprotkb:Q91887|uniprotkb:Q91888|uniprotkb:Q9BWD6|uniprotkb:Q9BX98|uniprotkb:Q9UEF2|uniprotkb:Q9UEG1|uniprotkb:Q9UEK8|uniprotkb:Q9UPK7|uniprotkb:P62988|ensembl:ENSP00000304697|ensembl:ENSP00000379178|ensembl:ENSP00000379180|ensembl:ENSP00000478771	psi-mi:bre1a_human(display_long)|uniprotkb:RNF20(gene name)|psi-mi:RNF20(display_short)|uniprotkb:BRE1A(gene name synonym)|uniprotkb:RING finger protein 20(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BRE1A(gene name synonym)	psi-mi:ubb_human(display_long)|uniprotkb:UBB(gene name)|psi-mi:UBB(display_short)	psi-mi:"MI:0415"(enzymatic study)	Kim et al. (2009)	imex:IM-12178|pubmed:19410543	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2410894|imex:IM-12178-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011517164.1|refseq:NP_062538.5|dip:DIP-53411N|ensembl:ENSG00000155827(gene)|ensembl:ENST00000389120(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002039"(p53 binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0031062"(positive regulation of histone methylation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033503"(HULC complex)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0042393"(histone binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:1900364"(negative regulation of mRNA polyadenylation)|go:"GO:2001168"(positive regulation of histone H2B ubiquitination)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013956(E3 ubiquitin ligase, BRE1)|interpro:IPR017907|mint:Q5VTR2|rcsb pdb:5TRB|reactome:R-HSA-8866654|reactome:R-HSA-9013422	refseq:NP_061828.1|refseq:NP_001268645.1|refseq:NP_001268646.1|refseq:NP_001268647.1|refseq:NP_001268648.1|refseq:NP_001268649.1|interpro:IPR019954|interpro:IPR019956|interpro:IPR029071|mint:P0CG47|go:"GO:0047497"(mitochondrion transport along microtubule)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0060613"(fat pad development)|rcsb pdb:2KHW|rcsb pdb:2MBB|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070062"(extracellular exosome)|rcsb pdb:2MRO|go:"GO:0072520"(seminiferous tubule development)|go:"GO:0097009"(energy homeostasis)|rcsb pdb:2MSG|go:"GO:1901214"(regulation of neuron death)|rcsb pdb:2N13|rcsb pdb:4UEL|rcsb pdb:4UF6|rcsb pdb:4WHV|rcsb pdb:4WLR|rcsb pdb:4WUR|rcsb pdb:4XOF|rcsb pdb:4ZFR|rcsb pdb:4ZFT|go:"GO:1902255"(positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1902527"(positive regulation of protein monoubiquitination)|rcsb pdb:4ZPZ|rcsb pdb:4ZUX|rcsb pdb:5BNB|rcsb pdb:5CAW|rcsb pdb:5CRA|rcsb pdb:5CVM|rcsb pdb:5CVN|rcsb pdb:5CVO|interpro:IPR000626(Ubiquitin)|rcsb pdb:5D0K|rcsb pdb:5D0M|rcsb pdb:5DFL|rcsb pdb:5DK8|rcsb pdb:5E6J|rcsb pdb:5EDV|rcsb pdb:5EMZ|rcsb pdb:5EYA|rcsb pdb:5GJQ|rcsb pdb:5GO7|rcsb pdb:5GO8|rcsb pdb:5GOB|rcsb pdb:5GOC|rcsb pdb:5GOD|rcsb pdb:5GOG|rcsb pdb:5GOH|rcsb pdb:5GOI|rcsb pdb:5GOJ|rcsb pdb:5GOK|rcsb pdb:5H7S|rcsb pdb:5IBK|rcsb pdb:5IFR|rcsb pdb:5JBY|rcsb pdb:5JG6|rcsb pdb:5JP3|rcsb pdb:5JTJ|rcsb pdb:5JTV|rcsb pdb:5K9P|rcsb pdb:5KGF|rcsb pdb:5KHY|rcsb pdb:5KYC|rcsb pdb:5KYD|rcsb pdb:5KYE|rcsb pdb:5KYF|rcsb pdb:5L8H|rcsb pdb:5L8W|rcsb pdb:5L9T|rcsb pdb:5LN1|rcsb pdb:5LRV|rcsb pdb:5LRW|rcsb pdb:5LRX|rcsb pdb:5M93|rcsb pdb:5MNJ|rcsb pdb:5N2W|rcsb pdb:5N38|rcsb pdb:5NL5|rcsb pdb:5NLJ|rcsb pdb:5NVG|rcsb pdb:5O44|rcsb pdb:5O6T|rcsb pdb:5OHK|rcsb pdb:5OHL|rcsb pdb:5OHN|rcsb pdb:5OHP|rcsb pdb:5TOF|rcsb pdb:5TOG|rcsb pdb:5TUT|rcsb pdb:5TXK|rcsb pdb:5UJL|rcsb pdb:5UJN|rcsb pdb:5ULF|rcsb pdb:5ULH|rcsb pdb:5ULK|rcsb pdb:5V1Y|rcsb pdb:5V1Z|rcsb pdb:5VEY|rcsb pdb:5VF0|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5VZM|rcsb pdb:5VZW|rcsb pdb:5W46|rcsb pdb:5WFI|rcsb pdb:5X3M|rcsb pdb:5X3N|rcsb pdb:5X3O|rcsb pdb:5XBO|rcsb pdb:5XDP|rcsb pdb:5XK4|rcsb pdb:5XK5|rcsb pdb:5XPK|rcsb pdb:5YDR|rcsb pdb:5YIJ|rcsb pdb:5YIK|rcsb pdb:5YMY|rcsb pdb:5YT6|rcsb pdb:5ZBU|rcsb pdb:5ZD0|rcsb pdb:6ASR|rcsb pdb:6BVA|rcsb pdb:6BYH|rcsb pdb:6C16|rcsb pdb:6CP2|rcsb pdb:6DGF|rcsb pdb:6EI1|rcsb pdb:6FDK|rcsb pdb:6FGE|rcsb pdb:6FTX|rcsb pdb:6FX4|rcsb pdb:6FYH|rcsb pdb:6GLC|rcsb pdb:6GZS|rcsb pdb:6H4H|rcsb pdb:6HEI|rcsb pdb:6HEK|rcsb pdb:6IF1|rcsb pdb:6ISU|rcsb pdb:6JB6|rcsb pdb:6JB7|rcsb pdb:6JMA|rcsb pdb:6K4I|rcsb pdb:6K9P|rcsb pdb:6KOW|rcsb pdb:6KOX|rcsb pdb:6LP2|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6N13|rcsb pdb:6NJ9|rcsb pdb:6NJG|rcsb pdb:6O96|rcsb pdb:6OAM|rcsb pdb:6PGV|rcsb pdb:6PZV|rcsb pdb:6QF8|rcsb pdb:6QK9|rcsb pdb:6QML|rcsb pdb:6TBM|rcsb pdb:6UH5|rcsb pdb:6XAA|rcsb pdb:7AY2|rcsb pdb:7BBD|rcsb pdb:7CAP|rcsb pdb:7JMS|rcsb pdb:7LYC|reactome:R-HSA-110312|reactome:R-HSA-110314|reactome:R-HSA-110320|reactome:R-HSA-1169091|reactome:R-HSA-1169408|reactome:R-HSA-1234176|reactome:R-HSA-1236382|reactome:R-HSA-1236974|reactome:R-HSA-1253288|reactome:R-HSA-1295596|reactome:R-HSA-1358803|reactome:R-HSA-162588|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-168928|reactome:R-HSA-174048|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174184|reactome:R-HSA-174490|reactome:R-HSA-175474|reactome:R-HSA-179409|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-182971|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-201681|reactome:R-HSA-202424|reactome:R-HSA-205043|reactome:R-HSA-209543|reactome:R-HSA-209560|reactome:R-HSA-211733|reactome:R-HSA-2122947|reactome:R-HSA-2122948|reactome:R-HSA-2173788|reactome:R-HSA-2173791|reactome:R-HSA-174178|reactome:R-HSA-2173795|reactome:R-HSA-2173796|reactome:R-HSA-2467813|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559585|reactome:R-HSA-2565942|reactome:R-HSA-2644606|reactome:R-HSA-2672351|reactome:R-HSA-2691232|reactome:R-HSA-2871837|reactome:R-HSA-2894862|reactome:R-HSA-2979096|reactome:R-HSA-3134975|reactome:R-HSA-3322077|reactome:R-HSA-349425|reactome:R-HSA-3769402|reactome:R-HSA-3785653|reactome:R-HSA-382556|reactome:R-HSA-400253|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-4641263|reactome:R-HSA-5205685|reactome:R-HSA-532668|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5655862|reactome:R-HSA-5656121|reactome:R-HSA-5656169|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5675221|reactome:R-HSA-5675482|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5684264|reactome:R-HSA-5685942|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689877|reactome:R-HSA-5689880|reactome:R-HSA-5689896|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693607|reactome:R-HSA-5696394|reactome:R-HSA-5696395|reactome:R-HSA-5696397|reactome:R-HSA-5696400|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6783310|reactome:R-HSA-6804756|reactome:R-HSA-6804757|reactome:R-HSA-6804760|reactome:R-HSA-6807004|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69231|reactome:R-HSA-69481|reactome:R-HSA-69541|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8849469|reactome:R-HSA-983168|reactome:R-HSA-8852276|reactome:R-HSA-8941858|reactome:R-HSA-8854050|reactome:R-HSA-8856825|reactome:R-HSA-8948747|reactome:R-HSA-8948751|reactome:R-HSA-8856828|reactome:R-HSA-8951664|reactome:R-HSA-8863795|reactome:R-HSA-8866652|reactome:R-HSA-8866654|reactome:R-HSA-8875360|reactome:R-HSA-8876493|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-901032|reactome:R-HSA-9010553|reactome:R-HSA-9013507|reactome:R-HSA-9013973|reactome:R-HSA-9014325|reactome:R-HSA-9020702|reactome:R-HSA-9033241|reactome:R-HSA-912631|reactome:R-HSA-917729|reactome:R-HSA-917937|reactome:R-HSA-936440|reactome:R-HSA-936964|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-937042|reactome:R-HSA-937072|reactome:R-HSA-9604323|reactome:R-HSA-9613829|reactome:R-HSA-9615710|reactome:R-HSA-9636383|reactome:R-HSA-9637628|reactome:R-HSA-9645460|reactome:R-HSA-9646399|reactome:R-HSA-9648002|reactome:R-HSA-9664873|reactome:R-HSA-9683683|reactome:R-HSA-9694493|reactome:R-HSA-9705462|reactome:R-HSA-9706369|reactome:R-HSA-9706377|reactome:R-HSA-9708530|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-975163|reactome:R-HSA-977225|ensembl:ENSG00000170315(gene)|ensembl:ENST00000302182(transcript)|ensembl:ENST00000395837(transcript)|ensembl:ENST00000395839(transcript)|ensembl:ENST00000614404(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007141"(male meiosis I)|go:"GO:0007144"(female meiosis I)|go:"GO:0008585"(female gonad development)|go:"GO:0010008"(endosome membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019941"(modification-dependent protein catabolic process)|go:"GO:0021888"(hypothalamus gonadotrophin-releasing hormone neuron development)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031386"(protein tag)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031982"(vesicle)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)	go:"GO:0004842"(ubiquitin-protein transferase activity)	-	-	figure legend:Fig. 3D, Supp. Fig. 5|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/06/01	2018/09/18	rogid:zscBhEtpu0D69sPn1wXsEGBIiOY9606	rogid:X2Y1hzv2uGZd9FObQD2Qq3SECRo9606	intact-crc:9E9C17459CC1098A|rigid:A75v6lhTVXu6pu2w0qg7NZuxnRU	false	flag tag:?-?	32p radiolabel:?-?|his tag:?-?|ha tag:?-?	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q5VTR2	uniprotkb:P63146	intact:EBI-2372238|uniprotkb:Q2TB34|uniprotkb:Q69YL5|uniprotkb:Q6P527|uniprotkb:Q8N3J4|uniprotkb:Q96JD3|uniprotkb:Q9H9Y7|uniprotkb:Q9HA51|uniprotkb:Q9NUR4|uniprotkb:Q9NWQ3|uniprotkb:Q9NX83|uniprotkb:A7MCT5|ensembl:ENSP00000373772	intact:EBI-712629|uniprotkb:P23567|uniprotkb:Q4PJ15|ensembl:ENSP00000265339|uniprotkb:Q9D0J6|uniprotkb:B2R503|uniprotkb:D3DQA2	psi-mi:bre1a_human(display_long)|uniprotkb:RNF20(gene name)|psi-mi:RNF20(display_short)|uniprotkb:BRE1A(gene name synonym)|uniprotkb:RING finger protein 20(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BRE1A(gene name synonym)	psi-mi:ube2b_human(display_long)|uniprotkb:Ubiquitin-protein ligase B(gene name synonym)|uniprotkb:Ubiquitin carrier protein B(gene name synonym)|uniprotkb:RAD6 homolog B(gene name synonym)|uniprotkb:Ubiquitin-conjugating enzyme E2-17 kDa(gene name synonym)|uniprotkb:UBE2B(gene name)|psi-mi:UBE2B(display_short)|uniprotkb:RAD6B(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme B(gene name synonym)	psi-mi:"MI:0415"(enzymatic study)	Kim et al. (2009)	imex:IM-12178|pubmed:19410543	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2410894|imex:IM-12178-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011517164.1|refseq:NP_062538.5|dip:DIP-53411N|ensembl:ENSG00000155827(gene)|ensembl:ENST00000389120(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002039"(p53 binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0031062"(positive regulation of histone methylation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033503"(HULC complex)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0042393"(histone binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:1900364"(negative regulation of mRNA polyadenylation)|go:"GO:2001168"(positive regulation of histone H2B ubiquitination)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013956(E3 ubiquitin ligase, BRE1)|interpro:IPR017907|mint:Q5VTR2|rcsb pdb:5TRB|reactome:R-HSA-8866654|reactome:R-HSA-9013422	ensembl:ENSG00000119048(gene)|ensembl:ENST00000265339(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000785"(chromatin)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001741"(XY body)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006281"(DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007288"(sperm axoneme assembly)|go:"GO:0009411"(response to UV)|go:"GO:0010845"(positive regulation of reciprocal meiotic recombination)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|interpro:IPR023313|mint:P63146|rcsb pdb:1JAS|rcsb pdb:1NXA|rcsb pdb:2Y4W|rcsb pdb:2YB6|rcsb pdb:2YBF|reactome:R-HSA-110314|reactome:R-HSA-8866652|reactome:R-HSA-8866654|reactome:R-HSA-983168|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033128"(negative regulation of histone phosphorylation)|go:"GO:0033503"(HULC complex)|go:"GO:0033522"(histone H2A ubiquitination)|go:"GO:0042493"|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043951"(negative regulation of cAMP-mediated signaling)|go:"GO:0045141"(meiotic telomere clustering)|go:"GO:0050821"(protein stabilization)|go:"GO:0051026"(chiasma assembly)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070076"(histone lysine demethylation)|go:"GO:0070193"(synaptonemal complex organization)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070829"(obsolete heterochromatin maintenance)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0070979"(protein K11-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|refseq:NP_003328.1|dip:DIP-29832N	go:"GO:0004842"(ubiquitin-protein transferase activity)	-	-	figure legend:Fig. 3D, Supp. Fig. 5|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/06/01	2018/09/18	rogid:zscBhEtpu0D69sPn1wXsEGBIiOY9606	rogid:JvcUPH+3qQXicPsIRFnW19NOc3c9606	intact-crc:9E9C17459CC1098A|rigid:A75v6lhTVXu6pu2w0qg7NZuxnRU	false	flag tag:?-?	mutation:88-88	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:Q5VTR2	uniprotkb:O75150	intact:EBI-2372238|uniprotkb:Q2TB34|uniprotkb:Q69YL5|uniprotkb:Q6P527|uniprotkb:Q8N3J4|uniprotkb:Q96JD3|uniprotkb:Q9H9Y7|uniprotkb:Q9HA51|uniprotkb:Q9NUR4|uniprotkb:Q9NWQ3|uniprotkb:Q9NX83|uniprotkb:A7MCT5|ensembl:ENSP00000373772	intact:EBI-744408|uniprotkb:Q6AHZ6|uniprotkb:Q6N005|uniprotkb:Q7L3T6|uniprotkb:Q8N615|uniprotkb:Q96T18|uniprotkb:Q9BSV9|uniprotkb:Q9HC82|ensembl:ENSP00000325677|uniprotkb:A0A024QZG0	psi-mi:bre1a_human(display_long)|uniprotkb:RNF20(gene name)|psi-mi:RNF20(display_short)|uniprotkb:BRE1A(gene name synonym)|uniprotkb:RING finger protein 20(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BRE1A(gene name synonym)	psi-mi:bre1b_human(display_long)|uniprotkb:95 kDa retinoblastoma-associated protein(gene name synonym)|uniprotkb:RING finger protein 40(gene name synonym)|uniprotkb:RNF40(gene name)|psi-mi:RNF40(display_short)|uniprotkb:BRE1B(gene name synonym)|uniprotkb:KIAA0661(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BRE1B(gene name synonym)	psi-mi:"MI:0415"(enzymatic study)	Kim et al. (2009)	imex:IM-12178|pubmed:19410543	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2410920|imex:IM-12178-16	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011517164.1|refseq:NP_062538.5|dip:DIP-53411N|ensembl:ENSG00000155827(gene)|ensembl:ENST00000389120(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002039"(p53 binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0031062"(positive regulation of histone methylation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033503"(HULC complex)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0042393"(histone binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:1900364"(negative regulation of mRNA polyadenylation)|go:"GO:2001168"(positive regulation of histone H2B ubiquitination)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013956(E3 ubiquitin ligase, BRE1)|interpro:IPR017907|mint:Q5VTR2|rcsb pdb:5TRB|reactome:R-HSA-8866654|reactome:R-HSA-9013422	refseq:NP_001273501.1|refseq:NP_001193962.1|refseq:NP_001193963.1|refseq:NP_055586.1|go:"GO:1900364"(negative regulation of mRNA polyadenylation)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902916"(positive regulation of protein polyubiquitination)|go:"GO:2001168"(positive regulation of histone H2B ubiquitination)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013956(E3 ubiquitin ligase, BRE1)|interpro:IPR017907|mint:O75150|reactome:R-HSA-8866654|go:"GO:0046872"(metal ion binding)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043679"(axon terminus)|go:"GO:0044877"(protein-containing complex binding)|ensembl:ENSG00000103549(gene)|ensembl:ENST00000324685(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0016020"(membrane)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033503"(HULC complex)	go:"GO:0004842"(ubiquitin-protein transferase activity)	-	-	figure legend:Fig. 3D, Supp. Fig. 5|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/06/01	2018/09/18	rogid:zscBhEtpu0D69sPn1wXsEGBIiOY9606	rogid:POkQZhEBe4cw3Y9V3YOwJDgvYJ89606	intact-crc:C6CBF65488D04B5F|rigid:l6Y/2f3+7jyWkiM4Qs6kjc41S1Y	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q5VTR2	uniprotkb:P22314	intact:EBI-2372238|uniprotkb:Q2TB34|uniprotkb:Q69YL5|uniprotkb:Q6P527|uniprotkb:Q8N3J4|uniprotkb:Q96JD3|uniprotkb:Q9H9Y7|uniprotkb:Q9HA51|uniprotkb:Q9NUR4|uniprotkb:Q9NWQ3|uniprotkb:Q9NX83|uniprotkb:A7MCT5|ensembl:ENSP00000373772	intact:EBI-709688|uniprotkb:Q96E13|uniprotkb:Q5JRR8|ensembl:ENSP00000338413|ensembl:ENSP00000366568	psi-mi:bre1a_human(display_long)|uniprotkb:RNF20(gene name)|psi-mi:RNF20(display_short)|uniprotkb:BRE1A(gene name synonym)|uniprotkb:RING finger protein 20(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BRE1A(gene name synonym)	psi-mi:uba1_human(display_long)|uniprotkb:Ubiquitin-activating enzyme E1(gene name synonym)|uniprotkb:Protein A1S9(gene name synonym)|uniprotkb:UBA1(gene name)|psi-mi:UBA1(display_short)|uniprotkb:A1S9T(gene name synonym)|uniprotkb:UBE1(gene name synonym)	psi-mi:"MI:0415"(enzymatic study)	Kim et al. (2009)	imex:IM-12178|pubmed:19410543	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2410920|imex:IM-12178-16	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011517164.1|refseq:NP_062538.5|dip:DIP-53411N|ensembl:ENSG00000155827(gene)|ensembl:ENST00000389120(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002039"(p53 binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0031062"(positive regulation of histone methylation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033503"(HULC complex)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0042393"(histone binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:1900364"(negative regulation of mRNA polyadenylation)|go:"GO:2001168"(positive regulation of histone H2B ubiquitination)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013956(E3 ubiquitin ligase, BRE1)|interpro:IPR017907|mint:Q5VTR2|rcsb pdb:5TRB|reactome:R-HSA-8866654|reactome:R-HSA-9013422	refseq:NP_003325.2|refseq:NP_695012.1|refseq:XP_016885269.1|refseq:XP_016885270.1|dip:DIP-33686N|ensembl:ENSG00000130985(gene)|ensembl:ENST00000335972(transcript)|ensembl:ENST00000377351(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004839"(ubiquitin activating enzyme activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000011(Ubiquitin-activating enzyme, E1)|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR018074|interpro:IPR018075|interpro:IPR018965|interpro:IPR019572|interpro:IPR032418|interpro:IPR032420|interpro:IPR033127|interpro:IPR035985|interpro:IPR038252|interpro:IPR042063|interpro:IPR042302|interpro:IPR042449|mint:P22314|rcsb pdb:4P22|rcsb pdb:6DC6|reactome:R-HSA-8866652|reactome:R-HSA-983168	go:"GO:0004842"(ubiquitin-protein transferase activity)	-	-	figure legend:Fig. 3D, Supp. Fig. 5|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/06/01	2018/09/18	rogid:zscBhEtpu0D69sPn1wXsEGBIiOY9606	rogid:q+vEeA0XLST0Zz173bmEt0dNbDE9606	intact-crc:C6CBF65488D04B5F|rigid:l6Y/2f3+7jyWkiM4Qs6kjc41S1Y	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q5VTR2	uniprotkb:P0CG47	intact:EBI-2372238|uniprotkb:Q2TB34|uniprotkb:Q69YL5|uniprotkb:Q6P527|uniprotkb:Q8N3J4|uniprotkb:Q96JD3|uniprotkb:Q9H9Y7|uniprotkb:Q9HA51|uniprotkb:Q9NUR4|uniprotkb:Q9NWQ3|uniprotkb:Q9NX83|uniprotkb:A7MCT5|ensembl:ENSP00000373772	intact:EBI-413034|uniprotkb:P02248|uniprotkb:P02249|uniprotkb:P02250|uniprotkb:Q29120|uniprotkb:Q6LBL4|uniprotkb:Q6LDU5|uniprotkb:Q8WYN8|uniprotkb:Q91887|uniprotkb:Q91888|uniprotkb:Q9BWD6|uniprotkb:Q9BX98|uniprotkb:Q9UEF2|uniprotkb:Q9UEG1|uniprotkb:Q9UEK8|uniprotkb:Q9UPK7|uniprotkb:P62988|ensembl:ENSP00000304697|ensembl:ENSP00000379178|ensembl:ENSP00000379180|ensembl:ENSP00000478771	psi-mi:bre1a_human(display_long)|uniprotkb:RNF20(gene name)|psi-mi:RNF20(display_short)|uniprotkb:BRE1A(gene name synonym)|uniprotkb:RING finger protein 20(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BRE1A(gene name synonym)	psi-mi:ubb_human(display_long)|uniprotkb:UBB(gene name)|psi-mi:UBB(display_short)	psi-mi:"MI:0415"(enzymatic study)	Kim et al. (2009)	imex:IM-12178|pubmed:19410543	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2410920|imex:IM-12178-16	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011517164.1|refseq:NP_062538.5|dip:DIP-53411N|ensembl:ENSG00000155827(gene)|ensembl:ENST00000389120(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002039"(p53 binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0031062"(positive regulation of histone methylation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033503"(HULC complex)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0042393"(histone binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:1900364"(negative regulation of mRNA polyadenylation)|go:"GO:2001168"(positive regulation of histone H2B ubiquitination)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013956(E3 ubiquitin ligase, BRE1)|interpro:IPR017907|mint:Q5VTR2|rcsb pdb:5TRB|reactome:R-HSA-8866654|reactome:R-HSA-9013422	refseq:NP_061828.1|refseq:NP_001268645.1|refseq:NP_001268646.1|refseq:NP_001268647.1|refseq:NP_001268648.1|refseq:NP_001268649.1|interpro:IPR019954|interpro:IPR019956|interpro:IPR029071|mint:P0CG47|go:"GO:0047497"(mitochondrion transport along microtubule)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0060613"(fat pad development)|rcsb pdb:2KHW|rcsb pdb:2MBB|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070062"(extracellular exosome)|rcsb pdb:2MRO|go:"GO:0072520"(seminiferous tubule development)|go:"GO:0097009"(energy homeostasis)|rcsb pdb:2MSG|go:"GO:1901214"(regulation of neuron death)|rcsb pdb:2N13|rcsb pdb:4UEL|rcsb pdb:4UF6|rcsb pdb:4WHV|rcsb pdb:4WLR|rcsb pdb:4WUR|rcsb pdb:4XOF|rcsb pdb:4ZFR|rcsb pdb:4ZFT|go:"GO:1902255"(positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1902527"(positive regulation of protein monoubiquitination)|rcsb pdb:4ZPZ|rcsb pdb:4ZUX|rcsb pdb:5BNB|rcsb pdb:5CAW|rcsb pdb:5CRA|rcsb pdb:5CVM|rcsb pdb:5CVN|rcsb pdb:5CVO|interpro:IPR000626(Ubiquitin)|rcsb pdb:5D0K|rcsb pdb:5D0M|rcsb pdb:5DFL|rcsb pdb:5DK8|rcsb pdb:5E6J|rcsb pdb:5EDV|rcsb pdb:5EMZ|rcsb pdb:5EYA|rcsb pdb:5GJQ|rcsb pdb:5GO7|rcsb pdb:5GO8|rcsb pdb:5GOB|rcsb pdb:5GOC|rcsb pdb:5GOD|rcsb pdb:5GOG|rcsb pdb:5GOH|rcsb pdb:5GOI|rcsb pdb:5GOJ|rcsb pdb:5GOK|rcsb pdb:5H7S|rcsb pdb:5IBK|rcsb pdb:5IFR|rcsb pdb:5JBY|rcsb pdb:5JG6|rcsb pdb:5JP3|rcsb pdb:5JTJ|rcsb pdb:5JTV|rcsb pdb:5K9P|rcsb pdb:5KGF|rcsb pdb:5KHY|rcsb pdb:5KYC|rcsb pdb:5KYD|rcsb pdb:5KYE|rcsb pdb:5KYF|rcsb pdb:5L8H|rcsb pdb:5L8W|rcsb pdb:5L9T|rcsb pdb:5LN1|rcsb pdb:5LRV|rcsb pdb:5LRW|rcsb pdb:5LRX|rcsb pdb:5M93|rcsb pdb:5MNJ|rcsb pdb:5N2W|rcsb pdb:5N38|rcsb pdb:5NL5|rcsb pdb:5NLJ|rcsb pdb:5NVG|rcsb pdb:5O44|rcsb pdb:5O6T|rcsb pdb:5OHK|rcsb pdb:5OHL|rcsb pdb:5OHN|rcsb pdb:5OHP|rcsb pdb:5TOF|rcsb pdb:5TOG|rcsb pdb:5TUT|rcsb pdb:5TXK|rcsb pdb:5UJL|rcsb pdb:5UJN|rcsb pdb:5ULF|rcsb pdb:5ULH|rcsb pdb:5ULK|rcsb pdb:5V1Y|rcsb pdb:5V1Z|rcsb pdb:5VEY|rcsb pdb:5VF0|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5VZM|rcsb pdb:5VZW|rcsb pdb:5W46|rcsb pdb:5WFI|rcsb pdb:5X3M|rcsb pdb:5X3N|rcsb pdb:5X3O|rcsb pdb:5XBO|rcsb pdb:5XDP|rcsb pdb:5XK4|rcsb pdb:5XK5|rcsb pdb:5XPK|rcsb pdb:5YDR|rcsb pdb:5YIJ|rcsb pdb:5YIK|rcsb pdb:5YMY|rcsb pdb:5YT6|rcsb pdb:5ZBU|rcsb pdb:5ZD0|rcsb pdb:6ASR|rcsb pdb:6BVA|rcsb pdb:6BYH|rcsb pdb:6C16|rcsb pdb:6CP2|rcsb pdb:6DGF|rcsb pdb:6EI1|rcsb pdb:6FDK|rcsb pdb:6FGE|rcsb pdb:6FTX|rcsb pdb:6FX4|rcsb pdb:6FYH|rcsb pdb:6GLC|rcsb pdb:6GZS|rcsb pdb:6H4H|rcsb pdb:6HEI|rcsb pdb:6HEK|rcsb pdb:6IF1|rcsb pdb:6ISU|rcsb pdb:6JB6|rcsb pdb:6JB7|rcsb pdb:6JMA|rcsb pdb:6K4I|rcsb pdb:6K9P|rcsb pdb:6KOW|rcsb pdb:6KOX|rcsb pdb:6LP2|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6N13|rcsb pdb:6NJ9|rcsb pdb:6NJG|rcsb pdb:6O96|rcsb pdb:6OAM|rcsb pdb:6PGV|rcsb pdb:6PZV|rcsb pdb:6QF8|rcsb pdb:6QK9|rcsb pdb:6QML|rcsb pdb:6TBM|rcsb pdb:6UH5|rcsb pdb:6XAA|rcsb pdb:7AY2|rcsb pdb:7BBD|rcsb pdb:7CAP|rcsb pdb:7JMS|rcsb pdb:7LYC|reactome:R-HSA-110312|reactome:R-HSA-110314|reactome:R-HSA-110320|reactome:R-HSA-1169091|reactome:R-HSA-1169408|reactome:R-HSA-1234176|reactome:R-HSA-1236382|reactome:R-HSA-1236974|reactome:R-HSA-1253288|reactome:R-HSA-1295596|reactome:R-HSA-1358803|reactome:R-HSA-162588|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-168928|reactome:R-HSA-174048|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174184|reactome:R-HSA-174490|reactome:R-HSA-175474|reactome:R-HSA-179409|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-182971|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-201681|reactome:R-HSA-202424|reactome:R-HSA-205043|reactome:R-HSA-209543|reactome:R-HSA-209560|reactome:R-HSA-211733|reactome:R-HSA-2122947|reactome:R-HSA-2122948|reactome:R-HSA-2173788|reactome:R-HSA-2173791|reactome:R-HSA-174178|reactome:R-HSA-2173795|reactome:R-HSA-2173796|reactome:R-HSA-2467813|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559585|reactome:R-HSA-2565942|reactome:R-HSA-2644606|reactome:R-HSA-2672351|reactome:R-HSA-2691232|reactome:R-HSA-2871837|reactome:R-HSA-2894862|reactome:R-HSA-2979096|reactome:R-HSA-3134975|reactome:R-HSA-3322077|reactome:R-HSA-349425|reactome:R-HSA-3769402|reactome:R-HSA-3785653|reactome:R-HSA-382556|reactome:R-HSA-400253|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-4641263|reactome:R-HSA-5205685|reactome:R-HSA-532668|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5655862|reactome:R-HSA-5656121|reactome:R-HSA-5656169|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5675221|reactome:R-HSA-5675482|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5684264|reactome:R-HSA-5685942|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689877|reactome:R-HSA-5689880|reactome:R-HSA-5689896|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693607|reactome:R-HSA-5696394|reactome:R-HSA-5696395|reactome:R-HSA-5696397|reactome:R-HSA-5696400|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6783310|reactome:R-HSA-6804756|reactome:R-HSA-6804757|reactome:R-HSA-6804760|reactome:R-HSA-6807004|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69231|reactome:R-HSA-69481|reactome:R-HSA-69541|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8849469|reactome:R-HSA-983168|reactome:R-HSA-8852276|reactome:R-HSA-8941858|reactome:R-HSA-8854050|reactome:R-HSA-8856825|reactome:R-HSA-8948747|reactome:R-HSA-8948751|reactome:R-HSA-8856828|reactome:R-HSA-8951664|reactome:R-HSA-8863795|reactome:R-HSA-8866652|reactome:R-HSA-8866654|reactome:R-HSA-8875360|reactome:R-HSA-8876493|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-901032|reactome:R-HSA-9010553|reactome:R-HSA-9013507|reactome:R-HSA-9013973|reactome:R-HSA-9014325|reactome:R-HSA-9020702|reactome:R-HSA-9033241|reactome:R-HSA-912631|reactome:R-HSA-917729|reactome:R-HSA-917937|reactome:R-HSA-936440|reactome:R-HSA-936964|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-937042|reactome:R-HSA-937072|reactome:R-HSA-9604323|reactome:R-HSA-9613829|reactome:R-HSA-9615710|reactome:R-HSA-9636383|reactome:R-HSA-9637628|reactome:R-HSA-9645460|reactome:R-HSA-9646399|reactome:R-HSA-9648002|reactome:R-HSA-9664873|reactome:R-HSA-9683683|reactome:R-HSA-9694493|reactome:R-HSA-9705462|reactome:R-HSA-9706369|reactome:R-HSA-9706377|reactome:R-HSA-9708530|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-975163|reactome:R-HSA-977225|ensembl:ENSG00000170315(gene)|ensembl:ENST00000302182(transcript)|ensembl:ENST00000395837(transcript)|ensembl:ENST00000395839(transcript)|ensembl:ENST00000614404(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007141"(male meiosis I)|go:"GO:0007144"(female meiosis I)|go:"GO:0008585"(female gonad development)|go:"GO:0010008"(endosome membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019941"(modification-dependent protein catabolic process)|go:"GO:0021888"(hypothalamus gonadotrophin-releasing hormone neuron development)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031386"(protein tag)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031982"(vesicle)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)	go:"GO:0004842"(ubiquitin-protein transferase activity)	-	-	figure legend:Fig. 3D, Supp. Fig. 5|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/06/01	2018/09/18	rogid:zscBhEtpu0D69sPn1wXsEGBIiOY9606	rogid:X2Y1hzv2uGZd9FObQD2Qq3SECRo9606	intact-crc:C6CBF65488D04B5F|rigid:l6Y/2f3+7jyWkiM4Qs6kjc41S1Y	false	flag tag:?-?	his tag:?-?|ha tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q5VTR2	uniprotkb:P49459	intact:EBI-2372238|uniprotkb:Q2TB34|uniprotkb:Q69YL5|uniprotkb:Q6P527|uniprotkb:Q8N3J4|uniprotkb:Q96JD3|uniprotkb:Q9H9Y7|uniprotkb:Q9HA51|uniprotkb:Q9NUR4|uniprotkb:Q9NWQ3|uniprotkb:Q9NX83|uniprotkb:A7MCT5|ensembl:ENSP00000373772	intact:EBI-2339348|uniprotkb:A6NMF5|uniprotkb:Q96FX4|uniprotkb:B2R7R9|uniprotkb:Q4TTG1|uniprotkb:D3DWI1|uniprotkb:A6NFE9|uniprotkb:A6NGR2|ensembl:ENSP00000360613	psi-mi:bre1a_human(display_long)|uniprotkb:RNF20(gene name)|psi-mi:RNF20(display_short)|uniprotkb:BRE1A(gene name synonym)|uniprotkb:RING finger protein 20(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BRE1A(gene name synonym)	psi-mi:ube2a_human(display_long)|uniprotkb:UBE2A(gene name)|psi-mi:UBE2A(display_short)|uniprotkb:RAD6A(gene name synonym)|uniprotkb:Ubiquitin-protein ligase A(gene name synonym)|uniprotkb:Ubiquitin carrier protein A(gene name synonym)|uniprotkb:RAD6 homolog A(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme A(gene name synonym)	psi-mi:"MI:0415"(enzymatic study)	Kim et al. (2009)	imex:IM-12178|pubmed:19410543	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2410920|imex:IM-12178-16	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011517164.1|refseq:NP_062538.5|dip:DIP-53411N|ensembl:ENSG00000155827(gene)|ensembl:ENST00000389120(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002039"(p53 binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0031062"(positive regulation of histone methylation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033503"(HULC complex)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0042393"(histone binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:1900364"(negative regulation of mRNA polyadenylation)|go:"GO:2001168"(positive regulation of histone H2B ubiquitination)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013956(E3 ubiquitin ligase, BRE1)|interpro:IPR017907|mint:Q5VTR2|rcsb pdb:5TRB|reactome:R-HSA-8866654|reactome:R-HSA-9013422	refseq:NP_003327.2|refseq:NP_861427.1|refseq:NP_001269090.1|dip:DIP-24260N|ensembl:ENSG00000077721(gene)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000785"(chromatin)|go:"GO:0001741"(XY body)|go:"GO:0001835"(blastocyst hatching)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009411"(response to UV)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033503"(HULC complex)|go:"GO:0033522"(histone H2A ubiquitination)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0060135"(maternal process involved in female pregnancy)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0070979"(protein K11-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|mint:P49459|rcsb pdb:6CYO|rcsb pdb:6CYR|reactome:R-HSA-8866652|reactome:R-HSA-8866654|reactome:R-HSA-983168|ensembl:ENST00000371558(transcript)	go:"GO:0004842"(ubiquitin-protein transferase activity)	-	-	figure legend:Fig. 3D, Supp. Fig. 5|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/06/01	2018/09/18	rogid:zscBhEtpu0D69sPn1wXsEGBIiOY9606	rogid:T6Mzgy6RHO9HoEIG3FmQvsP32vU9606	intact-crc:C6CBF65488D04B5F|rigid:l6Y/2f3+7jyWkiM4Qs6kjc41S1Y	false	flag tag:?-?	mutation:88-88	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q5VTR2	uniprotkb:O75150	intact:EBI-2372238|uniprotkb:Q2TB34|uniprotkb:Q69YL5|uniprotkb:Q6P527|uniprotkb:Q8N3J4|uniprotkb:Q96JD3|uniprotkb:Q9H9Y7|uniprotkb:Q9HA51|uniprotkb:Q9NUR4|uniprotkb:Q9NWQ3|uniprotkb:Q9NX83|uniprotkb:A7MCT5|ensembl:ENSP00000373772	intact:EBI-744408|uniprotkb:Q6AHZ6|uniprotkb:Q6N005|uniprotkb:Q7L3T6|uniprotkb:Q8N615|uniprotkb:Q96T18|uniprotkb:Q9BSV9|uniprotkb:Q9HC82|ensembl:ENSP00000325677|uniprotkb:A0A024QZG0	psi-mi:bre1a_human(display_long)|uniprotkb:RNF20(gene name)|psi-mi:RNF20(display_short)|uniprotkb:BRE1A(gene name synonym)|uniprotkb:RING finger protein 20(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BRE1A(gene name synonym)	psi-mi:bre1b_human(display_long)|uniprotkb:95 kDa retinoblastoma-associated protein(gene name synonym)|uniprotkb:RING finger protein 40(gene name synonym)|uniprotkb:RNF40(gene name)|psi-mi:RNF40(display_short)|uniprotkb:BRE1B(gene name synonym)|uniprotkb:KIAA0661(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BRE1B(gene name synonym)	psi-mi:"MI:0415"(enzymatic study)	Kim et al. (2009)	imex:IM-12178|pubmed:19410543	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2410937|imex:IM-12178-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011517164.1|refseq:NP_062538.5|dip:DIP-53411N|ensembl:ENSG00000155827(gene)|ensembl:ENST00000389120(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002039"(p53 binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0031062"(positive regulation of histone methylation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033503"(HULC complex)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0042393"(histone binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:1900364"(negative regulation of mRNA polyadenylation)|go:"GO:2001168"(positive regulation of histone H2B ubiquitination)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013956(E3 ubiquitin ligase, BRE1)|interpro:IPR017907|mint:Q5VTR2|rcsb pdb:5TRB|reactome:R-HSA-8866654|reactome:R-HSA-9013422	refseq:NP_001273501.1|refseq:NP_001193962.1|refseq:NP_001193963.1|refseq:NP_055586.1|go:"GO:1900364"(negative regulation of mRNA polyadenylation)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902916"(positive regulation of protein polyubiquitination)|go:"GO:2001168"(positive regulation of histone H2B ubiquitination)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013956(E3 ubiquitin ligase, BRE1)|interpro:IPR017907|mint:O75150|reactome:R-HSA-8866654|go:"GO:0046872"(metal ion binding)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043679"(axon terminus)|go:"GO:0044877"(protein-containing complex binding)|ensembl:ENSG00000103549(gene)|ensembl:ENST00000324685(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0016020"(membrane)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033503"(HULC complex)	go:"GO:0004842"(ubiquitin-protein transferase activity)	-	-	figure legend:Fig. 3D, Supp. Fig. 5|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/06/01	2018/09/18	rogid:zscBhEtpu0D69sPn1wXsEGBIiOY9606	rogid:POkQZhEBe4cw3Y9V3YOwJDgvYJ89606	intact-crc:0B4E111011514048|rigid:A75v6lhTVXu6pu2w0qg7NZuxnRU	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q5VTR2	uniprotkb:P22314	intact:EBI-2372238|uniprotkb:Q2TB34|uniprotkb:Q69YL5|uniprotkb:Q6P527|uniprotkb:Q8N3J4|uniprotkb:Q96JD3|uniprotkb:Q9H9Y7|uniprotkb:Q9HA51|uniprotkb:Q9NUR4|uniprotkb:Q9NWQ3|uniprotkb:Q9NX83|uniprotkb:A7MCT5|ensembl:ENSP00000373772	intact:EBI-709688|uniprotkb:Q96E13|uniprotkb:Q5JRR8|ensembl:ENSP00000338413|ensembl:ENSP00000366568	psi-mi:bre1a_human(display_long)|uniprotkb:RNF20(gene name)|psi-mi:RNF20(display_short)|uniprotkb:BRE1A(gene name synonym)|uniprotkb:RING finger protein 20(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BRE1A(gene name synonym)	psi-mi:uba1_human(display_long)|uniprotkb:Ubiquitin-activating enzyme E1(gene name synonym)|uniprotkb:Protein A1S9(gene name synonym)|uniprotkb:UBA1(gene name)|psi-mi:UBA1(display_short)|uniprotkb:A1S9T(gene name synonym)|uniprotkb:UBE1(gene name synonym)	psi-mi:"MI:0415"(enzymatic study)	Kim et al. (2009)	imex:IM-12178|pubmed:19410543	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2410937|imex:IM-12178-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011517164.1|refseq:NP_062538.5|dip:DIP-53411N|ensembl:ENSG00000155827(gene)|ensembl:ENST00000389120(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002039"(p53 binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0031062"(positive regulation of histone methylation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033503"(HULC complex)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0042393"(histone binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:1900364"(negative regulation of mRNA polyadenylation)|go:"GO:2001168"(positive regulation of histone H2B ubiquitination)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013956(E3 ubiquitin ligase, BRE1)|interpro:IPR017907|mint:Q5VTR2|rcsb pdb:5TRB|reactome:R-HSA-8866654|reactome:R-HSA-9013422	refseq:NP_003325.2|refseq:NP_695012.1|refseq:XP_016885269.1|refseq:XP_016885270.1|dip:DIP-33686N|ensembl:ENSG00000130985(gene)|ensembl:ENST00000335972(transcript)|ensembl:ENST00000377351(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0004839"(ubiquitin activating enzyme activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032446"(protein modification by small protein conjugation)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000011(Ubiquitin-activating enzyme, E1)|interpro:IPR000594(UBA/THIF-type NAD/FAD binding fold)|interpro:IPR018074|interpro:IPR018075|interpro:IPR018965|interpro:IPR019572|interpro:IPR032418|interpro:IPR032420|interpro:IPR033127|interpro:IPR035985|interpro:IPR038252|interpro:IPR042063|interpro:IPR042302|interpro:IPR042449|mint:P22314|rcsb pdb:4P22|rcsb pdb:6DC6|reactome:R-HSA-8866652|reactome:R-HSA-983168	go:"GO:0004842"(ubiquitin-protein transferase activity)	-	-	figure legend:Fig. 3D, Supp. Fig. 5|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/06/01	2018/09/18	rogid:zscBhEtpu0D69sPn1wXsEGBIiOY9606	rogid:q+vEeA0XLST0Zz173bmEt0dNbDE9606	intact-crc:0B4E111011514048|rigid:A75v6lhTVXu6pu2w0qg7NZuxnRU	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q5VTR2	uniprotkb:P0CG47	intact:EBI-2372238|uniprotkb:Q2TB34|uniprotkb:Q69YL5|uniprotkb:Q6P527|uniprotkb:Q8N3J4|uniprotkb:Q96JD3|uniprotkb:Q9H9Y7|uniprotkb:Q9HA51|uniprotkb:Q9NUR4|uniprotkb:Q9NWQ3|uniprotkb:Q9NX83|uniprotkb:A7MCT5|ensembl:ENSP00000373772	intact:EBI-413034|uniprotkb:P02248|uniprotkb:P02249|uniprotkb:P02250|uniprotkb:Q29120|uniprotkb:Q6LBL4|uniprotkb:Q6LDU5|uniprotkb:Q8WYN8|uniprotkb:Q91887|uniprotkb:Q91888|uniprotkb:Q9BWD6|uniprotkb:Q9BX98|uniprotkb:Q9UEF2|uniprotkb:Q9UEG1|uniprotkb:Q9UEK8|uniprotkb:Q9UPK7|uniprotkb:P62988|ensembl:ENSP00000304697|ensembl:ENSP00000379178|ensembl:ENSP00000379180|ensembl:ENSP00000478771	psi-mi:bre1a_human(display_long)|uniprotkb:RNF20(gene name)|psi-mi:RNF20(display_short)|uniprotkb:BRE1A(gene name synonym)|uniprotkb:RING finger protein 20(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BRE1A(gene name synonym)	psi-mi:ubb_human(display_long)|uniprotkb:UBB(gene name)|psi-mi:UBB(display_short)	psi-mi:"MI:0415"(enzymatic study)	Kim et al. (2009)	imex:IM-12178|pubmed:19410543	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2410937|imex:IM-12178-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0684"(ancillary)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011517164.1|refseq:NP_062538.5|dip:DIP-53411N|ensembl:ENSG00000155827(gene)|ensembl:ENST00000389120(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002039"(p53 binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0031062"(positive regulation of histone methylation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033503"(HULC complex)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0042393"(histone binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:1900364"(negative regulation of mRNA polyadenylation)|go:"GO:2001168"(positive regulation of histone H2B ubiquitination)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013956(E3 ubiquitin ligase, BRE1)|interpro:IPR017907|mint:Q5VTR2|rcsb pdb:5TRB|reactome:R-HSA-8866654|reactome:R-HSA-9013422	refseq:NP_061828.1|refseq:NP_001268645.1|refseq:NP_001268646.1|refseq:NP_001268647.1|refseq:NP_001268648.1|refseq:NP_001268649.1|interpro:IPR019954|interpro:IPR019956|interpro:IPR029071|mint:P0CG47|go:"GO:0047497"(mitochondrion transport along microtubule)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0060613"(fat pad development)|rcsb pdb:2KHW|rcsb pdb:2MBB|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:0070062"(extracellular exosome)|rcsb pdb:2MRO|go:"GO:0072520"(seminiferous tubule development)|go:"GO:0097009"(energy homeostasis)|rcsb pdb:2MSG|go:"GO:1901214"(regulation of neuron death)|rcsb pdb:2N13|rcsb pdb:4UEL|rcsb pdb:4UF6|rcsb pdb:4WHV|rcsb pdb:4WLR|rcsb pdb:4WUR|rcsb pdb:4XOF|rcsb pdb:4ZFR|rcsb pdb:4ZFT|go:"GO:1902255"(positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1902527"(positive regulation of protein monoubiquitination)|rcsb pdb:4ZPZ|rcsb pdb:4ZUX|rcsb pdb:5BNB|rcsb pdb:5CAW|rcsb pdb:5CRA|rcsb pdb:5CVM|rcsb pdb:5CVN|rcsb pdb:5CVO|interpro:IPR000626(Ubiquitin)|rcsb pdb:5D0K|rcsb pdb:5D0M|rcsb pdb:5DFL|rcsb pdb:5DK8|rcsb pdb:5E6J|rcsb pdb:5EDV|rcsb pdb:5EMZ|rcsb pdb:5EYA|rcsb pdb:5GJQ|rcsb pdb:5GO7|rcsb pdb:5GO8|rcsb pdb:5GOB|rcsb pdb:5GOC|rcsb pdb:5GOD|rcsb pdb:5GOG|rcsb pdb:5GOH|rcsb pdb:5GOI|rcsb pdb:5GOJ|rcsb pdb:5GOK|rcsb pdb:5H7S|rcsb pdb:5IBK|rcsb pdb:5IFR|rcsb pdb:5JBY|rcsb pdb:5JG6|rcsb pdb:5JP3|rcsb pdb:5JTJ|rcsb pdb:5JTV|rcsb pdb:5K9P|rcsb pdb:5KGF|rcsb pdb:5KHY|rcsb pdb:5KYC|rcsb pdb:5KYD|rcsb pdb:5KYE|rcsb pdb:5KYF|rcsb pdb:5L8H|rcsb pdb:5L8W|rcsb pdb:5L9T|rcsb pdb:5LN1|rcsb pdb:5LRV|rcsb pdb:5LRW|rcsb pdb:5LRX|rcsb pdb:5M93|rcsb pdb:5MNJ|rcsb pdb:5N2W|rcsb pdb:5N38|rcsb pdb:5NL5|rcsb pdb:5NLJ|rcsb pdb:5NVG|rcsb pdb:5O44|rcsb pdb:5O6T|rcsb pdb:5OHK|rcsb pdb:5OHL|rcsb pdb:5OHN|rcsb pdb:5OHP|rcsb pdb:5TOF|rcsb pdb:5TOG|rcsb pdb:5TUT|rcsb pdb:5TXK|rcsb pdb:5UJL|rcsb pdb:5UJN|rcsb pdb:5ULF|rcsb pdb:5ULH|rcsb pdb:5ULK|rcsb pdb:5V1Y|rcsb pdb:5V1Z|rcsb pdb:5VEY|rcsb pdb:5VF0|rcsb pdb:5VNZ|rcsb pdb:5VO0|rcsb pdb:5VZM|rcsb pdb:5VZW|rcsb pdb:5W46|rcsb pdb:5WFI|rcsb pdb:5X3M|rcsb pdb:5X3N|rcsb pdb:5X3O|rcsb pdb:5XBO|rcsb pdb:5XDP|rcsb pdb:5XK4|rcsb pdb:5XK5|rcsb pdb:5XPK|rcsb pdb:5YDR|rcsb pdb:5YIJ|rcsb pdb:5YIK|rcsb pdb:5YMY|rcsb pdb:5YT6|rcsb pdb:5ZBU|rcsb pdb:5ZD0|rcsb pdb:6ASR|rcsb pdb:6BVA|rcsb pdb:6BYH|rcsb pdb:6C16|rcsb pdb:6CP2|rcsb pdb:6DGF|rcsb pdb:6EI1|rcsb pdb:6FDK|rcsb pdb:6FGE|rcsb pdb:6FTX|rcsb pdb:6FX4|rcsb pdb:6FYH|rcsb pdb:6GLC|rcsb pdb:6GZS|rcsb pdb:6H4H|rcsb pdb:6HEI|rcsb pdb:6HEK|rcsb pdb:6IF1|rcsb pdb:6ISU|rcsb pdb:6JB6|rcsb pdb:6JB7|rcsb pdb:6JMA|rcsb pdb:6K4I|rcsb pdb:6K9P|rcsb pdb:6KOW|rcsb pdb:6KOX|rcsb pdb:6LP2|rcsb pdb:6MSB|rcsb pdb:6MSD|rcsb pdb:6MSE|rcsb pdb:6MSG|rcsb pdb:6N13|rcsb pdb:6NJ9|rcsb pdb:6NJG|rcsb pdb:6O96|rcsb pdb:6OAM|rcsb pdb:6PGV|rcsb pdb:6PZV|rcsb pdb:6QF8|rcsb pdb:6QK9|rcsb pdb:6QML|rcsb pdb:6TBM|rcsb pdb:6UH5|rcsb pdb:6XAA|rcsb pdb:7AY2|rcsb pdb:7BBD|rcsb pdb:7CAP|rcsb pdb:7JMS|rcsb pdb:7LYC|reactome:R-HSA-110312|reactome:R-HSA-110314|reactome:R-HSA-110320|reactome:R-HSA-1169091|reactome:R-HSA-1169408|reactome:R-HSA-1234176|reactome:R-HSA-1236382|reactome:R-HSA-1236974|reactome:R-HSA-1253288|reactome:R-HSA-1295596|reactome:R-HSA-1358803|reactome:R-HSA-162588|reactome:R-HSA-168638|reactome:R-HSA-168927|reactome:R-HSA-168928|reactome:R-HSA-174048|reactome:R-HSA-174084|reactome:R-HSA-174113|reactome:R-HSA-174154|reactome:R-HSA-174184|reactome:R-HSA-174490|reactome:R-HSA-175474|reactome:R-HSA-179409|reactome:R-HSA-180534|reactome:R-HSA-180585|reactome:R-HSA-182971|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-201681|reactome:R-HSA-202424|reactome:R-HSA-205043|reactome:R-HSA-209543|reactome:R-HSA-209560|reactome:R-HSA-211733|reactome:R-HSA-2122947|reactome:R-HSA-2122948|reactome:R-HSA-2173788|reactome:R-HSA-2173791|reactome:R-HSA-174178|reactome:R-HSA-2173795|reactome:R-HSA-2173796|reactome:R-HSA-2467813|reactome:R-HSA-2559580|reactome:R-HSA-2559582|reactome:R-HSA-2559585|reactome:R-HSA-2565942|reactome:R-HSA-2644606|reactome:R-HSA-2672351|reactome:R-HSA-2691232|reactome:R-HSA-2871837|reactome:R-HSA-2894862|reactome:R-HSA-2979096|reactome:R-HSA-3134975|reactome:R-HSA-3322077|reactome:R-HSA-349425|reactome:R-HSA-3769402|reactome:R-HSA-3785653|reactome:R-HSA-382556|reactome:R-HSA-400253|reactome:R-HSA-445989|reactome:R-HSA-450302|reactome:R-HSA-450321|reactome:R-HSA-450408|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-4641258|reactome:R-HSA-4641263|reactome:R-HSA-5205685|reactome:R-HSA-532668|reactome:R-HSA-5357905|reactome:R-HSA-5357956|reactome:R-HSA-5358346|reactome:R-HSA-5362768|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5632684|reactome:R-HSA-5654726|reactome:R-HSA-5654727|reactome:R-HSA-5654732|reactome:R-HSA-5654733|reactome:R-HSA-5655862|reactome:R-HSA-5656121|reactome:R-HSA-5656169|reactome:R-HSA-5658442|reactome:R-HSA-5668541|reactome:R-HSA-5675221|reactome:R-HSA-5675482|reactome:R-HSA-5676590|reactome:R-HSA-5678895|reactome:R-HSA-5684264|reactome:R-HSA-5685942|reactome:R-HSA-5687128|reactome:R-HSA-5689603|reactome:R-HSA-5689877|reactome:R-HSA-5689880|reactome:R-HSA-5689896|reactome:R-HSA-5689901|reactome:R-HSA-5693565|reactome:R-HSA-5693607|reactome:R-HSA-5696394|reactome:R-HSA-5696395|reactome:R-HSA-5696397|reactome:R-HSA-5696400|reactome:R-HSA-6781823|reactome:R-HSA-6781827|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6783310|reactome:R-HSA-6804756|reactome:R-HSA-6804757|reactome:R-HSA-6804760|reactome:R-HSA-6807004|reactome:R-HSA-68827|reactome:R-HSA-68949|reactome:R-HSA-69017|reactome:R-HSA-69231|reactome:R-HSA-69481|reactome:R-HSA-69541|reactome:R-HSA-69601|reactome:R-HSA-75815|reactome:R-HSA-8849469|reactome:R-HSA-983168|reactome:R-HSA-8852276|reactome:R-HSA-8941858|reactome:R-HSA-8854050|reactome:R-HSA-8856825|reactome:R-HSA-8948747|reactome:R-HSA-8948751|reactome:R-HSA-8856828|reactome:R-HSA-8951664|reactome:R-HSA-8863795|reactome:R-HSA-8866652|reactome:R-HSA-8866654|reactome:R-HSA-8875360|reactome:R-HSA-8876493|reactome:R-HSA-8932339|reactome:R-HSA-8939236|reactome:R-HSA-8939902|reactome:R-HSA-901032|reactome:R-HSA-9010553|reactome:R-HSA-9013507|reactome:R-HSA-9013973|reactome:R-HSA-9014325|reactome:R-HSA-9020702|reactome:R-HSA-9033241|reactome:R-HSA-912631|reactome:R-HSA-917729|reactome:R-HSA-917937|reactome:R-HSA-936440|reactome:R-HSA-936964|reactome:R-HSA-937039|reactome:R-HSA-937041|reactome:R-HSA-937042|reactome:R-HSA-937072|reactome:R-HSA-9604323|reactome:R-HSA-9613829|reactome:R-HSA-9615710|reactome:R-HSA-9636383|reactome:R-HSA-9637628|reactome:R-HSA-9645460|reactome:R-HSA-9646399|reactome:R-HSA-9648002|reactome:R-HSA-9664873|reactome:R-HSA-9683683|reactome:R-HSA-9694493|reactome:R-HSA-9705462|reactome:R-HSA-9706369|reactome:R-HSA-9706377|reactome:R-HSA-9708530|reactome:R-HSA-975110|reactome:R-HSA-975144|reactome:R-HSA-975163|reactome:R-HSA-977225|ensembl:ENSG00000170315(gene)|ensembl:ENST00000302182(transcript)|ensembl:ENST00000395837(transcript)|ensembl:ENST00000395839(transcript)|ensembl:ENST00000614404(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007141"(male meiosis I)|go:"GO:0007144"(female meiosis I)|go:"GO:0008585"(female gonad development)|go:"GO:0010008"(endosome membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019941"(modification-dependent protein catabolic process)|go:"GO:0021888"(hypothalamus gonadotrophin-releasing hormone neuron development)|go:"GO:0030666"(endocytic vesicle membrane)|go:"GO:0031386"(protein tag)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031982"(vesicle)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)	go:"GO:0004842"(ubiquitin-protein transferase activity)	-	-	figure legend:Fig. 3D, Supp. Fig. 5|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/06/01	2018/09/18	rogid:zscBhEtpu0D69sPn1wXsEGBIiOY9606	rogid:X2Y1hzv2uGZd9FObQD2Qq3SECRo9606	intact-crc:0B4E111011514048|rigid:A75v6lhTVXu6pu2w0qg7NZuxnRU	false	flag tag:?-?	his tag:?-?|ha tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q5VTR2	uniprotkb:P63146	intact:EBI-2372238|uniprotkb:Q2TB34|uniprotkb:Q69YL5|uniprotkb:Q6P527|uniprotkb:Q8N3J4|uniprotkb:Q96JD3|uniprotkb:Q9H9Y7|uniprotkb:Q9HA51|uniprotkb:Q9NUR4|uniprotkb:Q9NWQ3|uniprotkb:Q9NX83|uniprotkb:A7MCT5|ensembl:ENSP00000373772	intact:EBI-712629|uniprotkb:P23567|uniprotkb:Q4PJ15|ensembl:ENSP00000265339|uniprotkb:Q9D0J6|uniprotkb:B2R503|uniprotkb:D3DQA2	psi-mi:bre1a_human(display_long)|uniprotkb:RNF20(gene name)|psi-mi:RNF20(display_short)|uniprotkb:BRE1A(gene name synonym)|uniprotkb:RING finger protein 20(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BRE1A(gene name synonym)	psi-mi:ube2b_human(display_long)|uniprotkb:Ubiquitin-protein ligase B(gene name synonym)|uniprotkb:Ubiquitin carrier protein B(gene name synonym)|uniprotkb:RAD6 homolog B(gene name synonym)|uniprotkb:Ubiquitin-conjugating enzyme E2-17 kDa(gene name synonym)|uniprotkb:UBE2B(gene name)|psi-mi:UBE2B(display_short)|uniprotkb:RAD6B(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme B(gene name synonym)	psi-mi:"MI:0415"(enzymatic study)	Kim et al. (2009)	imex:IM-12178|pubmed:19410543	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0220"(ubiquitination reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2410937|imex:IM-12178-15	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011517164.1|refseq:NP_062538.5|dip:DIP-53411N|ensembl:ENSG00000155827(gene)|ensembl:ENST00000389120(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002039"(p53 binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0031062"(positive regulation of histone methylation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033503"(HULC complex)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0042393"(histone binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:1900364"(negative regulation of mRNA polyadenylation)|go:"GO:2001168"(positive regulation of histone H2B ubiquitination)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013956(E3 ubiquitin ligase, BRE1)|interpro:IPR017907|mint:Q5VTR2|rcsb pdb:5TRB|reactome:R-HSA-8866654|reactome:R-HSA-9013422	ensembl:ENSG00000119048(gene)|ensembl:ENST00000265339(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000785"(chromatin)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001741"(XY body)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006281"(DNA repair)|go:"GO:0006301"(postreplication repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007288"(sperm axoneme assembly)|go:"GO:0009411"(response to UV)|go:"GO:0010845"(positive regulation of reciprocal meiotic recombination)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|interpro:IPR023313|mint:P63146|rcsb pdb:1JAS|rcsb pdb:1NXA|rcsb pdb:2Y4W|rcsb pdb:2YB6|rcsb pdb:2YBF|reactome:R-HSA-110314|reactome:R-HSA-8866652|reactome:R-HSA-8866654|reactome:R-HSA-983168|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033128"(negative regulation of histone phosphorylation)|go:"GO:0033503"(HULC complex)|go:"GO:0033522"(histone H2A ubiquitination)|go:"GO:0042493"|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043951"(negative regulation of cAMP-mediated signaling)|go:"GO:0045141"(meiotic telomere clustering)|go:"GO:0050821"(protein stabilization)|go:"GO:0051026"(chiasma assembly)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|go:"GO:0070076"(histone lysine demethylation)|go:"GO:0070193"(synaptonemal complex organization)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070829"(obsolete heterochromatin maintenance)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0070979"(protein K11-linked ubiquitination)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|refseq:NP_003328.1|dip:DIP-29832N	go:"GO:0004842"(ubiquitin-protein transferase activity)	-	-	figure legend:Fig. 3D, Supp. Fig. 5|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/06/01	2018/09/18	rogid:zscBhEtpu0D69sPn1wXsEGBIiOY9606	rogid:JvcUPH+3qQXicPsIRFnW19NOc3c9606	intact-crc:0B4E111011514048|rigid:A75v6lhTVXu6pu2w0qg7NZuxnRU	false	flag tag:?-?	mutation:88-88	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8N7H5	uniprotkb:Q9GZS3	intact:EBI-2607770|uniprotkb:O75239|uniprotkb:Q9H166|uniprotkb:Q9NUU9|ensembl:ENSP00000221265|uniprotkb:M0QX35	intact:EBI-358545|uniprotkb:D3DW84|uniprotkb:Q6IA22|uniprotkb:Q7Z4X4|ensembl:ENSP00000267973|ensembl:ENSP00000453801	psi-mi:paf1_human(display_long)|uniprotkb:PAF1(gene name)|psi-mi:PAF1(display_short)|uniprotkb:PD2(gene name synonym)|uniprotkb:Pancreatic differentiation protein 2(gene name synonym)	psi-mi:wdr61_human(display_long)|uniprotkb:WDR61(gene name)|psi-mi:WDR61(display_short)|uniprotkb:Meiotic recombination REC14 protein homolog(gene name synonym)|uniprotkb:SKI8 homolog(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kim et al. (2009)	imex:IM-12178|pubmed:19410543	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2410969|imex:IM-12178-18	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_061961.2|ensembl:ENSG00000006712(gene)|ensembl:ENST00000221265(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001711"(endodermal cell fate commitment)|go:"GO:0003682"(chromatin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0006378"(mRNA polyadenylation)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016584"(nucleosome positioning)|go:"GO:0016593"(Cdc73/Paf1 complex)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030054"(cell junction)|go:"GO:0031062"(positive regulation of histone methylation)|go:"GO:0031442"(positive regulation of mRNA 3'-end processing)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0035327"|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|interpro:IPR007133(RNA polymerase II-associated, Paf1)|mint:Q8N7H5|rcsb pdb:4M6T|rcsb pdb:5ZYQ|rcsb pdb:6GMH|rcsb pdb:6TED|reactome:R-HSA-112382|reactome:R-HSA-674695|reactome:R-HSA-75955|reactome:R-HSA-8866654|refseq:NP_001243755.1|dip:DIP-48673N	refseq:NP_079510.1|go:"GO:0080182"(histone H3-K4 trimethylation)|go:"GO:2001162"(positive regulation of histone H3-K79 methylation)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|mint:Q9GZS3|rcsb pdb:3OW8|rcsb pdb:6GMH|rcsb pdb:6TED|reactome:R-HSA-112382|reactome:R-HSA-429958|reactome:R-HSA-674695|reactome:R-HSA-75955|ensembl:ENSG00000140395(gene)|ensembl:ENST00000267973(transcript)|ensembl:ENST00000558311(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016593"(Cdc73/Paf1 complex)|go:"GO:0035327"|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0055087"(Ski complex)|reactome:R-HSA-8866654|refseq:XP_011520396.1|refseq:NP_001290176.1|refseq:NP_001290177.1|dip:DIP-36672N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 5A|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7108(spofr-sf_9)|taxid:7108(Spodoptera frugiperda insect cells)	-	2009/06/01	2014/10/16	rogid:5Bf9gSdxgaufI30DVL8QAyVLqNk9606	rogid:yVcjv2BXXr3VFSR7OcJ/1u9L6gw9606	intact-crc:93FD903C4813C412|rigid:f4KkRbrowg5XEhKcYy118fIBge8	false	flag tag:?-?	-	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:Q8N7H5	uniprotkb:Q8WVC0	intact:EBI-2607770|uniprotkb:O75239|uniprotkb:Q9H166|uniprotkb:Q9NUU9|ensembl:ENSP00000221265|uniprotkb:M0QX35	intact:EBI-932432|uniprotkb:Q96N99|ensembl:ENSP00000299601	psi-mi:paf1_human(display_long)|uniprotkb:PAF1(gene name)|psi-mi:PAF1(display_short)|uniprotkb:PD2(gene name synonym)|uniprotkb:Pancreatic differentiation protein 2(gene name synonym)	psi-mi:leo1_human(display_long)|uniprotkb:LEO1(gene name)|psi-mi:LEO1(display_short)|uniprotkb:RDL(gene name synonym)|uniprotkb:Replicative senescence down-regulated leo1-like protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kim et al. (2009)	imex:IM-12178|pubmed:19410543	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2410969|imex:IM-12178-18	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_061961.2|ensembl:ENSG00000006712(gene)|ensembl:ENST00000221265(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001711"(endodermal cell fate commitment)|go:"GO:0003682"(chromatin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0006378"(mRNA polyadenylation)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016584"(nucleosome positioning)|go:"GO:0016593"(Cdc73/Paf1 complex)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030054"(cell junction)|go:"GO:0031062"(positive regulation of histone methylation)|go:"GO:0031442"(positive regulation of mRNA 3'-end processing)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0035327"|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|interpro:IPR007133(RNA polymerase II-associated, Paf1)|mint:Q8N7H5|rcsb pdb:4M6T|rcsb pdb:5ZYQ|rcsb pdb:6GMH|rcsb pdb:6TED|reactome:R-HSA-112382|reactome:R-HSA-674695|reactome:R-HSA-75955|reactome:R-HSA-8866654|refseq:NP_001243755.1|dip:DIP-48673N	refseq:NP_001273359.1|refseq:NP_620147.1|dip:DIP-37885N|ensembl:ENSG00000166477(gene)|ensembl:ENST00000299601(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0001711"(endodermal cell fate commitment)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0006378"(mRNA polyadenylation)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016593"(Cdc73/Paf1 complex)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0031442"(positive regulation of mRNA 3'-end processing)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:1990269"(RNA polymerase II C-terminal domain phosphoserine binding)|interpro:IPR007149(Leo1-like protein)|mint:Q8WVC0|rcsb pdb:4M6T|rcsb pdb:6GMH|rcsb pdb:6TED|reactome:R-HSA-112382|reactome:R-HSA-201722|reactome:R-HSA-674695|reactome:R-HSA-75955|reactome:R-HSA-8866654	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 5A|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7108(spofr-sf_9)|taxid:7108(Spodoptera frugiperda insect cells)	-	2009/06/01	2014/10/16	rogid:5Bf9gSdxgaufI30DVL8QAyVLqNk9606	rogid:o0aaW4nxzWuPZ8/pMZpa9Qz9oEA9606	intact-crc:93FD903C4813C412|rigid:f4KkRbrowg5XEhKcYy118fIBge8	false	flag tag:?-?	-	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:Q8N7H5	uniprotkb:Q92541	intact:EBI-2607770|uniprotkb:O75239|uniprotkb:Q9H166|uniprotkb:Q9NUU9|ensembl:ENSP00000221265|uniprotkb:M0QX35	intact:EBI-1055239|uniprotkb:Q96BX6|ensembl:ENSP00000374280	psi-mi:paf1_human(display_long)|uniprotkb:PAF1(gene name)|psi-mi:PAF1(display_short)|uniprotkb:PD2(gene name synonym)|uniprotkb:Pancreatic differentiation protein 2(gene name synonym)	psi-mi:rtf1_human(display_long)|uniprotkb:RTF1(gene name)|psi-mi:RTF1(display_short)|uniprotkb:KIAA0252(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kim et al. (2009)	imex:IM-12178|pubmed:19410543	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2410969|imex:IM-12178-18	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_061961.2|ensembl:ENSG00000006712(gene)|ensembl:ENST00000221265(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001711"(endodermal cell fate commitment)|go:"GO:0003682"(chromatin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0006378"(mRNA polyadenylation)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016584"(nucleosome positioning)|go:"GO:0016593"(Cdc73/Paf1 complex)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030054"(cell junction)|go:"GO:0031062"(positive regulation of histone methylation)|go:"GO:0031442"(positive regulation of mRNA 3'-end processing)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0035327"|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|interpro:IPR007133(RNA polymerase II-associated, Paf1)|mint:Q8N7H5|rcsb pdb:4M6T|rcsb pdb:5ZYQ|rcsb pdb:6GMH|rcsb pdb:6TED|reactome:R-HSA-112382|reactome:R-HSA-674695|reactome:R-HSA-75955|reactome:R-HSA-8866654|refseq:NP_001243755.1|dip:DIP-48673N	refseq:NP_055953.3|ensembl:ENSG00000137815(gene)|ensembl:ENST00000389629(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001711"(endodermal cell fate commitment)|go:"GO:0001832"(blastocyst growth)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016593"(Cdc73/Paf1 complex)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0080182"(histone H3-K4 trimethylation)|go:"GO:1990269"(RNA polymerase II C-terminal domain phosphoserine binding)|interpro:IPR004343(Plus-3)|interpro:IPR036128|mint:Q92541|rcsb pdb:2BZE|rcsb pdb:2DB9|rcsb pdb:3U1U|rcsb pdb:4L1P|rcsb pdb:4L1U|rcsb pdb:6TED|reactome:R-HSA-112382|reactome:R-HSA-674695|reactome:R-HSA-75955|reactome:R-HSA-8866654	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 5A|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7108(spofr-sf_9)|taxid:7108(Spodoptera frugiperda insect cells)	-	2009/06/01	2014/10/16	rogid:5Bf9gSdxgaufI30DVL8QAyVLqNk9606	rogid:uWqJdVWJE0snWuZCdF0OkVWXRuI9606	intact-crc:93FD903C4813C412|rigid:f4KkRbrowg5XEhKcYy118fIBge8	false	flag tag:?-?	-	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:Q8N7H5	uniprotkb:Q6P1J9	intact:EBI-2607770|uniprotkb:O75239|uniprotkb:Q9H166|uniprotkb:Q9NUU9|ensembl:ENSP00000221265|uniprotkb:M0QX35	intact:EBI-930143|uniprotkb:A6NLZ8|uniprotkb:Q6PK51|uniprotkb:Q96A07|uniprotkb:Q9H245|uniprotkb:Q9H5L7|uniprotkb:B2RBR2|ensembl:ENSP00000356405	psi-mi:paf1_human(display_long)|uniprotkb:PAF1(gene name)|psi-mi:PAF1(display_short)|uniprotkb:PD2(gene name synonym)|uniprotkb:Pancreatic differentiation protein 2(gene name synonym)	psi-mi:cdc73_human(display_long)|uniprotkb:CDC73(gene name)|psi-mi:CDC73(display_short)|uniprotkb:C1orf28(gene name synonym)|uniprotkb:HRPT2(gene name synonym)|uniprotkb:Cell division cycle protein 73 homolog(gene name synonym)|uniprotkb:Hyperparathyroidism 2 protein(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kim et al. (2009)	imex:IM-12178|pubmed:19410543	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2410969|imex:IM-12178-18	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_061961.2|ensembl:ENSG00000006712(gene)|ensembl:ENST00000221265(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001711"(endodermal cell fate commitment)|go:"GO:0003682"(chromatin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0006378"(mRNA polyadenylation)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016584"(nucleosome positioning)|go:"GO:0016593"(Cdc73/Paf1 complex)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030054"(cell junction)|go:"GO:0031062"(positive regulation of histone methylation)|go:"GO:0031442"(positive regulation of mRNA 3'-end processing)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0035327"|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|interpro:IPR007133(RNA polymerase II-associated, Paf1)|mint:Q8N7H5|rcsb pdb:4M6T|rcsb pdb:5ZYQ|rcsb pdb:6GMH|rcsb pdb:6TED|reactome:R-HSA-112382|reactome:R-HSA-674695|reactome:R-HSA-75955|reactome:R-HSA-8866654|refseq:NP_001243755.1|dip:DIP-48673N	refseq:NP_078805.3|dip:DIP-37884N|ensembl:ENSG00000134371(gene)|ensembl:ENST00000367435(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001711"(endodermal cell fate commitment)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0006378"(mRNA polyadenylation)|go:"GO:0007049"(cell cycle)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016593"(Cdc73/Paf1 complex)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0031442"(positive regulation of mRNA 3'-end processing)|go:"GO:0031648"(protein destabilization)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0034402"(recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR007852(RNA polymerase II accessory factor, Cdc73)|interpro:IPR031336|interpro:IPR032041|interpro:IPR038103|mint:Q6P1J9|rcsb pdb:5YDE|rcsb pdb:5YDF|rcsb pdb:6TED|reactome:R-HSA-112382|reactome:R-HSA-201722|reactome:R-HSA-5632684|reactome:R-HSA-674695|reactome:R-HSA-75955|reactome:R-HSA-8866654	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 5A|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7108(spofr-sf_9)|taxid:7108(Spodoptera frugiperda insect cells)	-	2009/06/01	2014/10/16	rogid:5Bf9gSdxgaufI30DVL8QAyVLqNk9606	rogid:nuJ2kK0petj8iBr17I2BQzxcVmE9606	intact-crc:93FD903C4813C412|rigid:f4KkRbrowg5XEhKcYy118fIBge8	false	flag tag:?-?	-	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:Q8N7H5	uniprotkb:Q6PD62	intact:EBI-2607770|uniprotkb:O75239|uniprotkb:Q9H166|uniprotkb:Q9NUU9|ensembl:ENSP00000221265|uniprotkb:M0QX35	intact:EBI-1019583|uniprotkb:Q15015|uniprotkb:D3DQV8|ensembl:ENSP00000355013	psi-mi:paf1_human(display_long)|uniprotkb:PAF1(gene name)|psi-mi:PAF1(display_short)|uniprotkb:PD2(gene name synonym)|uniprotkb:Pancreatic differentiation protein 2(gene name synonym)	psi-mi:ctr9_human(display_long)|uniprotkb:CTR9(gene name)|psi-mi:CTR9(display_short)|uniprotkb:KIAA0155(gene name synonym)|uniprotkb:SH2BP1(gene name synonym)|uniprotkb:SH2 domain-binding protein 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kim et al. (2009)	imex:IM-12178|pubmed:19410543	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2410969|imex:IM-12178-18	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_061961.2|ensembl:ENSG00000006712(gene)|ensembl:ENST00000221265(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001711"(endodermal cell fate commitment)|go:"GO:0003682"(chromatin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0006378"(mRNA polyadenylation)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016584"(nucleosome positioning)|go:"GO:0016593"(Cdc73/Paf1 complex)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030054"(cell junction)|go:"GO:0031062"(positive regulation of histone methylation)|go:"GO:0031442"(positive regulation of mRNA 3'-end processing)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0035327"|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|interpro:IPR007133(RNA polymerase II-associated, Paf1)|mint:Q8N7H5|rcsb pdb:4M6T|rcsb pdb:5ZYQ|rcsb pdb:6GMH|rcsb pdb:6TED|reactome:R-HSA-112382|reactome:R-HSA-674695|reactome:R-HSA-75955|reactome:R-HSA-8866654|refseq:NP_001243755.1|dip:DIP-48673N	refseq:NP_055448.1|ensembl:ENSG00000198730(gene)|ensembl:ENST00000361367(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001711"(endodermal cell fate commitment)|go:"GO:0001826"(inner cell mass cell differentiation)|go:"GO:0001829"(trophectodermal cell differentiation)|go:"GO:0001832"(blastocyst growth)|go:"GO:0001835"(blastocyst hatching)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016593"(Cdc73/Paf1 complex)|go:"GO:0016607"(nuclear speck)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0035327"|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0051569"(regulation of histone H3-K4 methylation)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0080182"(histone H3-K4 trimethylation)|go:"GO:1900364"(negative regulation of mRNA polyadenylation)|go:"GO:2000653"(regulation of genetic imprinting)|go:"GO:2001162"(positive regulation of histone H3-K79 methylation)|go:"GO:2001168"(positive regulation of histone H2B ubiquitination)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR031101|mint:Q6PD62|rcsb pdb:5ZYQ|rcsb pdb:6GMH|rcsb pdb:6TED|reactome:R-HSA-112382|reactome:R-HSA-674695|reactome:R-HSA-75955|reactome:R-HSA-8866654|dip:DIP-31693N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 5A|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7108(spofr-sf_9)|taxid:7108(Spodoptera frugiperda insect cells)	-	2009/06/01	2014/10/16	rogid:5Bf9gSdxgaufI30DVL8QAyVLqNk9606	rogid:zEFAxq/VxkK8za6qsK0gcU+EU8o9606	intact-crc:93FD903C4813C412|rigid:f4KkRbrowg5XEhKcYy118fIBge8	false	flag tag:?-?	-	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:Q5VTR2	uniprotkb:O75150	intact:EBI-2372238|uniprotkb:Q2TB34|uniprotkb:Q69YL5|uniprotkb:Q6P527|uniprotkb:Q8N3J4|uniprotkb:Q96JD3|uniprotkb:Q9H9Y7|uniprotkb:Q9HA51|uniprotkb:Q9NUR4|uniprotkb:Q9NWQ3|uniprotkb:Q9NX83|uniprotkb:A7MCT5|ensembl:ENSP00000373772	intact:EBI-744408|uniprotkb:Q6AHZ6|uniprotkb:Q6N005|uniprotkb:Q7L3T6|uniprotkb:Q8N615|uniprotkb:Q96T18|uniprotkb:Q9BSV9|uniprotkb:Q9HC82|ensembl:ENSP00000325677|uniprotkb:A0A024QZG0	psi-mi:bre1a_human(display_long)|uniprotkb:RNF20(gene name)|psi-mi:RNF20(display_short)|uniprotkb:BRE1A(gene name synonym)|uniprotkb:RING finger protein 20(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BRE1A(gene name synonym)	psi-mi:bre1b_human(display_long)|uniprotkb:95 kDa retinoblastoma-associated protein(gene name synonym)|uniprotkb:RING finger protein 40(gene name synonym)|uniprotkb:RNF40(gene name)|psi-mi:RNF40(display_short)|uniprotkb:BRE1B(gene name synonym)|uniprotkb:KIAA0661(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BRE1B(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kim et al. (2009)	imex:IM-12178|pubmed:19410543	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2411007|imex:IM-12178-17	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011517164.1|refseq:NP_062538.5|dip:DIP-53411N|ensembl:ENSG00000155827(gene)|ensembl:ENST00000389120(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002039"(p53 binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0031062"(positive regulation of histone methylation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033503"(HULC complex)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0042393"(histone binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:1900364"(negative regulation of mRNA polyadenylation)|go:"GO:2001168"(positive regulation of histone H2B ubiquitination)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013956(E3 ubiquitin ligase, BRE1)|interpro:IPR017907|mint:Q5VTR2|rcsb pdb:5TRB|reactome:R-HSA-8866654|reactome:R-HSA-9013422	refseq:NP_001273501.1|refseq:NP_001193962.1|refseq:NP_001193963.1|refseq:NP_055586.1|go:"GO:1900364"(negative regulation of mRNA polyadenylation)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902916"(positive regulation of protein polyubiquitination)|go:"GO:2001168"(positive regulation of histone H2B ubiquitination)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013956(E3 ubiquitin ligase, BRE1)|interpro:IPR017907|mint:O75150|reactome:R-HSA-8866654|go:"GO:0046872"(metal ion binding)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043679"(axon terminus)|go:"GO:0044877"(protein-containing complex binding)|ensembl:ENSG00000103549(gene)|ensembl:ENST00000324685(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0016020"(membrane)|go:"GO:0017075"(syntaxin-1 binding)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033503"(HULC complex)	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 5B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7108(spofr-sf_9)|taxid:7108(Spodoptera frugiperda insect cells)	-	2009/06/01	2018/09/18	rogid:zscBhEtpu0D69sPn1wXsEGBIiOY9606	rogid:POkQZhEBe4cw3Y9V3YOwJDgvYJ89606	intact-crc:DF29518C22DBCE11|rigid:gq5a660ZKl+dvAJFWaW5PB01GdY	false	his tag:?-?	-	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:P04637	ensembl:ENSG00000124762	intact:EBI-366083|uniprotkb:Q15086|uniprotkb:Q15087|uniprotkb:Q15088|uniprotkb:Q16535|uniprotkb:Q16807|uniprotkb:Q16808|uniprotkb:Q16809|uniprotkb:Q16810|uniprotkb:Q16811|uniprotkb:Q16848|uniprotkb:Q86UG1|uniprotkb:Q8J016|uniprotkb:Q99659|uniprotkb:Q9BTM4|uniprotkb:Q9HAQ8|uniprotkb:Q9NP68|uniprotkb:Q9NPJ2|uniprotkb:Q9NZD0|uniprotkb:Q9UBI2|uniprotkb:Q9UQ61|ensembl:ENSP00000269305|ensembl:ENSP00000391478|intact:EBI-28980681|uniprotkb:Q2XN98|uniprotkb:Q3LRW1|uniprotkb:Q3LRW2|uniprotkb:Q3LRW3|uniprotkb:Q3LRW4|uniprotkb:Q3LRW5	intact:EBI-1550784	psi-mi:p53_human(display_long)|uniprotkb:TP53(gene name)|psi-mi:TP53(display_short)|uniprotkb:P53(gene name synonym)|uniprotkb:Tumor suppressor p53(gene name synonym)|uniprotkb:Phosphoprotein p53(gene name synonym)|uniprotkb:Antigen NY-CO-13(gene name synonym)	psi-mi:cdkn1a_human_gene(display_short)|psi-mi:ENSG00000124762(display_long)	psi-mi:"MI:0402"(chromatin immunoprecipitation assay)	Kim et al. (2009)	imex:IM-12178|pubmed:19410543	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2411141|imex:IM-12178-19	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0250"(gene)	refseq:NP_001263624.1|refseq:NP_001263625.1|ensembl:ENSG00000141510(gene)|ensembl:ENST00000269305(transcript)|ensembl:ENST00000445888(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0001094"(TFIID-class transcription factor complex binding)|go:"GO:0001216"(DNA-binding transcription activator activity)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001756"(somitogenesis)|go:"GO:0001836"(release of cytochrome c from mitochondria)|go:"GO:0002020"(protease binding)|go:"GO:0002039"(p53 binding)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0002309"(T cell proliferation involved in immune response)|go:"GO:0002360"(T cell lineage commitment)|go:"GO:0002326"(B cell lineage commitment)|go:"GO:0031497"(chromatin assembly)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034103"(regulation of tissue remodeling)|go:"GO:0034613"(cellular protein localization)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035033"(histone deacetylase regulator activity)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035690"|go:"GO:0035794"(positive regulation of mitochondrial membrane permeability)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036003"(positive regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0036310"(ATP-dependent DNA/DNA annealing activity)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0002931"(response to ischemia)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005507"(copper ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006914"(autophagy)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006977"(DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)|go:"GO:0006978"(DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator)|go:"GO:0006983"(ER overload response)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007369"(gastrulation)|go:"GO:0007406"(negative regulation of neuroblast proliferation)|go:"GO:0043153"(entrainment of circadian clock by photoperiod)|go:"GO:0043504"(mitochondrial DNA repair)|go:"GO:0043516"(regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0043621"(protein self-association)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045899"(positive regulation of RNA polymerase II transcription preinitiation complex assembly)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0048512"(circadian behavior)|go:"GO:0048539"(bone marrow development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051087"(chaperone binding)|go:"GO:0051097"(negative regulation of helicase activity)|go:"GO:0051262"(protein tetramerization)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0062100"(positive regulation of programmed necrotic cell death)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0060411"(cardiac septum morphogenesis)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070245"(positive regulation of thymocyte apoptotic process)|go:"GO:0070266"(necroptotic process)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0071494"(cellular response to UV-C)|go:"GO:0072331"(signal transduction by p53 class mediator)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0072717"(cellular response to actinomycin D)|go:"GO:0090200"(positive regulation of release of cytochrome c from mitochondria)|go:"GO:0090343"(positive regulation of cell aging)|go:"GO:0090399"(replicative senescence)|go:"GO:0090403"(oxidative stress-induced premature senescence)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0097252"(oligodendrocyte apoptotic process)|go:"GO:0097371"(MDM2/MDM4 family protein binding)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0140296"(general transcription initiation factor binding)|go:"GO:1900119"(positive regulation of execution phase of apoptosis)|go:"GO:1901525"(negative regulation of mitophagy)|go:"GO:1902108"(regulation of mitochondrial membrane permeability involved in apoptotic process)|go:"GO:1902253"(regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903799"(negative regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1904024"(negative regulation of glucose catabolic process to lactate via pyruvate)|go:"GO:1905856"(negative regulation of pentose-phosphate shunt)|go:"GO:1990144"(intrinsic apoptotic signaling pathway in response to hypoxia)|go:"GO:1990248"(regulation of transcription from RNA polymerase II promoter in response to DNA damage)|go:"GO:1990440"(positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:2000269"(regulation of fibroblast apoptotic process)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|go:"GO:2000772"(regulation of cellular senescence)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR002117(p53 tumor antigen)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR010991(p53, tetramerisation)|interpro:IPR011615(p53, DNA-binding)|go:"GO:0007569"(cell aging)|go:"GO:0008104"(protein localization)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008156"(negative regulation of DNA replication)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009299"(mRNA transcription)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009651"(response to salt stress)|go:"GO:0010165"(response to X-ray)|go:"GO:0010332"(response to gamma radiation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0016032"(viral process)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016605"(PML body)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031065"(positive regulation of histone deacetylation)|interpro:IPR012346(p53 and RUNT-type transcription factor, DNA-binding)|interpro:IPR013872("p53 transactivation domain (TAD)")|interpro:IPR036674|interpro:IPR040926|rcsb pdb:2ATA|rcsb pdb:2B3G|rcsb pdb:2BIM|rcsb pdb:2BIN|rcsb pdb:2BIO|rcsb pdb:2BIP|rcsb pdb:2AHI|rcsb pdb:2BIQ|rcsb pdb:2F1X|rcsb pdb:2FEJ|rcsb pdb:2FOJ|rcsb pdb:2FOO|rcsb pdb:2GS0|rcsb pdb:2H1L|rcsb pdb:2H2D|rcsb pdb:2H2F|rcsb pdb:2H4F|rcsb pdb:2H4H|rcsb pdb:2H4J|rcsb pdb:2H59|rcsb pdb:2J0Z|rcsb pdb:2J10|rcsb pdb:2J11|rcsb pdb:2J1W|rcsb pdb:2J1X|rcsb pdb:2J1Y|rcsb pdb:2J1Z|rcsb pdb:2J20|rcsb pdb:2J21|rcsb pdb:2K8F|rcsb pdb:2L14|rcsb pdb:2LY4|rcsb pdb:2MEJ|rcsb pdb:2MWO|rcsb pdb:2MWP|rcsb pdb:2MWY|rcsb pdb:2MZD|rcsb pdb:2OCJ|rcsb pdb:2PCX|rcsb pdb:1A1U|rcsb pdb:1AIE|rcsb pdb:1C26|rcsb pdb:1DT7|rcsb pdb:1GZH|rcsb pdb:1H26|rcsb pdb:1HS5|rcsb pdb:1JSP|rcsb pdb:1KZY|rcsb pdb:1MA3|rcsb pdb:1OLG|rcsb pdb:1OLH|rcsb pdb:1PES|rcsb pdb:1PET|mint:P04637|rcsb pdb:1SAE|rcsb pdb:1SAF|rcsb pdb:1SAK|rcsb pdb:1SAL|rcsb pdb:1TSR|rcsb pdb:1TUP|rcsb pdb:1UOL|rcsb pdb:1XQH|rcsb pdb:1YC5|rcsb pdb:1YCQ|rcsb pdb:1YCR|rcsb pdb:1YCS|rcsb pdb:2AC0|rcsb pdb:2ADY|refseq:NP_000537.3|refseq:NP_001119584.1|refseq:NP_001119585.1|refseq:NP_001119586.1|refseq:NP_001119587.1|refseq:NP_001119588.1|refseq:NP_001119589.1|rcsb pdb:2RUK|rcsb pdb:2VUK|rcsb pdb:3Q06|rcsb pdb:2WGX|rcsb pdb:2X0U|rcsb pdb:2X0V|rcsb pdb:2X0W|rcsb pdb:2XWR|rcsb pdb:2YBG|rcsb pdb:2YDR|rcsb pdb:2Z5S|rcsb pdb:2Z5T|rcsb pdb:3SAK|rcsb pdb:3D05|rcsb pdb:3D06|rcsb pdb:3D07|rcsb pdb:3D08|rcsb pdb:3D09|rcsb pdb:3D0A|rcsb pdb:3DAB|rcsb pdb:3DAC|rcsb pdb:3IGK|rcsb pdb:3IGL|rcsb pdb:3KMD|rcsb pdb:3TG5|rcsb pdb:3KZ8|rcsb pdb:3LW1|rcsb pdb:3OQ5|rcsb pdb:3PDH|rcsb pdb:3Q01|rcsb pdb:3Q05|rcsb pdb:3TS8|rcsb pdb:3ZME|rcsb pdb:4AGM|rcsb pdb:4AGN|rcsb pdb:4AGO|rcsb pdb:4AGP|rcsb pdb:4AGQ|rcsb pdb:4BUZ|rcsb pdb:4BV2|rcsb pdb:4HFZ|rcsb pdb:4HJE|rcsb pdb:4IBQ|rcsb pdb:4IBS|rcsb pdb:4IBT|rcsb pdb:4IBU|rcsb pdb:4IBV|rcsb pdb:4IBW|rcsb pdb:4IBY|rcsb pdb:4IBZ|rcsb pdb:4IJT|rcsb pdb:4KVP|rcsb pdb:4LO9|rcsb pdb:4LOE|rcsb pdb:4LOF|rcsb pdb:4MZI|rcsb pdb:4MZR|rcsb pdb:4QO1|rcsb pdb:4RP6|rcsb pdb:4RP7|rcsb pdb:4X34|rcsb pdb:4XR8|rcsb pdb:4ZZJ|rcsb pdb:5A7B|rcsb pdb:5AB9|rcsb pdb:5ABA|rcsb pdb:4AGL|rcsb pdb:5AOI|rcsb pdb:5AOJ|rcsb pdb:5AOK|rcsb pdb:5AOL|rcsb pdb:5AOM|rcsb pdb:6XRE|rcsb pdb:7BWN|rcsb pdb:7DHY|rcsb pdb:7DHZ|rcsb pdb:7EL4|reactome:R-HSA-111448|reactome:R-HSA-139915|reactome:R-HSA-1912408|reactome:R-HSA-2559580|reactome:R-HSA-2559584|reactome:R-HSA-2559585|reactome:R-HSA-2559586|reactome:R-HSA-3232118|reactome:R-HSA-349425|reactome:R-HSA-390471|reactome:R-HSA-5620971|reactome:R-HSA-5628897|reactome:R-HSA-5689880|reactome:R-HSA-5689896|reactome:R-HSA-5693565|reactome:R-HSA-6785807|reactome:R-HSA-6796648|reactome:R-HSA-6803204|reactome:R-HSA-6803205|reactome:R-HSA-6803207|reactome:R-HSA-6803211|reactome:R-HSA-6804114|reactome:R-HSA-6804115|reactome:R-HSA-6804116|reactome:R-HSA-6804754|reactome:R-HSA-6804756|reactome:R-HSA-6804757|reactome:R-HSA-6804758|reactome:R-HSA-6804759|reactome:R-HSA-6804760|reactome:R-HSA-6811555|reactome:R-HSA-69473|reactome:R-HSA-69481|reactome:R-HSA-69541|reactome:R-HSA-69895|reactome:R-HSA-8852276|reactome:R-HSA-8853884|reactome:R-HSA-8941855|reactome:R-HSA-8943724|reactome:R-HSA-983231|rcsb pdb:5ECG|rcsb pdb:5G4M|rcsb pdb:5G4N|rcsb pdb:5BUA|rcsb pdb:5G4O|rcsb pdb:5HOU|rcsb pdb:5HP0|rcsb pdb:5HPD|rcsb pdb:5LAP|rcsb pdb:5LGY|rcsb pdb:5MCT|rcsb pdb:5MCU|rcsb pdb:5MCV|rcsb pdb:5MCW|rcsb pdb:5MF7|rcsb pdb:5MG7|rcsb pdb:5MHC|rcsb pdb:5MOC|rcsb pdb:5O1A|rcsb pdb:5O1B|rcsb pdb:5O1C|rcsb pdb:5O1D|rcsb pdb:5O1E|rcsb pdb:5O1F|rcsb pdb:5O1G|rcsb pdb:5O1H|rcsb pdb:5O1I|rcsb pdb:5OL0|rcsb pdb:5UN8|rcsb pdb:5XZC|rcsb pdb:6FF9|rcsb pdb:6FJ5|rcsb pdb:6GGA|rcsb pdb:6GGB|rcsb pdb:6GGC|rcsb pdb:6GGD|rcsb pdb:6GGE|rcsb pdb:6GGF|rcsb pdb:6LHD|rcsb pdb:6R5L|rcsb pdb:6RJZ|rcsb pdb:6RK8|rcsb pdb:6RKI|rcsb pdb:6RKK|rcsb pdb:6RKM|rcsb pdb:6RL3|rcsb pdb:6RL4|rcsb pdb:6RL6|rcsb pdb:6RM5|rcsb pdb:6RM7|rcsb pdb:6RWH|rcsb pdb:6RWI|rcsb pdb:6RWS|rcsb pdb:6RWU|rcsb pdb:6RX2|rcsb pdb:6RZ3|rcsb pdb:6S39|rcsb pdb:6S40|rcsb pdb:6S9Q|rcsb pdb:6SHZ|rcsb pdb:6SI0|rcsb pdb:6SI1|rcsb pdb:6SI2|rcsb pdb:6SI3|rcsb pdb:6SI4|rcsb pdb:6SIN|rcsb pdb:6SIO|rcsb pdb:6SIP|rcsb pdb:6SIQ|rcsb pdb:6SL6|rcsb pdb:6SLV|rcsb pdb:6T58|rcsb pdb:6V4F|rcsb pdb:6V4H|rcsb pdb:6VQO|rcsb pdb:6VR1|rcsb pdb:6VR5|rcsb pdb:6VRM|rcsb pdb:6VRN|rcsb pdb:6W51|rcsb pdb:6S3C|ensembl:ENSP00000269305|ensembl:ENST00000420246|ensembl:ENSP00000391127|ensembl:ENSP00000391478|ensembl:ENST00000455263|ensembl:ENSP00000398846|ensembl:ENST00000504290|ensembl:ENSP00000484409|ensembl:ENST00000504937|ensembl:ENSP00000481179|ensembl:ENST00000510385|ensembl:ENSP00000478499|ensembl:ENST00000610292|ensembl:ENSP00000478219|ensembl:ENST00000610538|ensembl:ENSP00000480868|ensembl:ENST00000619485|ensembl:ENSP00000482537|ensembl:ENST00000620739|ensembl:ENSP00000481638|ensembl:ENST00000622645|ensembl:ENSP00000482222|refseq:NP_001119590.1|refseq:NP_001263626.1|refseq:NP_001263627.1|refseq:NP_001263628.1|refseq:NP_001263689.1|refseq:NP_001263690.1|dip:DIP-368N	-	-	-	-	comment:Binds to p53 response element 1 and to a lesser extent element 2. Binding increases over a 12 hour time period following stimultation.|agonist:Doxorubicin|figure legend:Fig. 7C|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hct116)|taxid:9606(Human colon carcinoma HCT116 cells)	-	2009/06/01	2014/10/16	rogid:fGN3kSCGIpi/D6d/X5kaB0Xu8/k9606	-	intact-crc:AEED7422445A8B38	false	-	-	-	-	psi-mi:"MI:0088"(primer specific pcr)	psi-mi:"MI:0088"(primer specific pcr)
uniprotkb:P28328	ensembl:ENSG00000124762	intact:EBI-713978|uniprotkb:Q567S6|ensembl:ENSP00000349543|ensembl:ENSP00000428590|ensembl:ENSP00000428638|uniprotkb:Q9BW41	intact:EBI-1550784	psi-mi:pex2_human(display_long)|uniprotkb:Peroxin-2(gene name synonym)|uniprotkb:Peroxisomal membrane protein 3(gene name synonym)|uniprotkb:35 kDa peroxisomal membrane protein(gene name synonym)|uniprotkb:RING finger protein 72(gene name synonym)|uniprotkb:PEX2(gene name)|psi-mi:PEX2(display_short)|uniprotkb:PAF1(gene name synonym)|uniprotkb:PXMP3(gene name synonym)|uniprotkb:PMP3(gene name synonym)|uniprotkb:PMP35(gene name synonym)|uniprotkb:RNF72(gene name synonym)|uniprotkb:Peroxisome assembly factor 1(gene name synonym)	psi-mi:cdkn1a_human_gene(display_short)|psi-mi:ENSG00000124762(display_long)	psi-mi:"MI:0402"(chromatin immunoprecipitation assay)	Kim et al. (2009)	imex:IM-12178|pubmed:19410543	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2411147|imex:IM-12178-20	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0250"(gene)	ensembl:ENSG00000164751(gene)|ensembl:ENST00000357039(transcript)|ensembl:ENST00000520103(transcript)|ensembl:ENST00000522527(transcript)|go:"GO:0000038"(very long-chain fatty acid metabolic process)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005779"(integral component of peroxisomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0007031"(peroxisome organization)|go:"GO:0016020"(membrane)|go:"GO:0016558"(protein import into peroxisome matrix)|go:"GO:0016593"(Cdc73/Paf1 complex)|go:"GO:0031648"(protein destabilization)|go:"GO:0046872"(metal ion binding)|go:"GO:0048147"(negative regulation of fibroblast proliferation)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR006845(Pex, N-terminal)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR018957|reactome:R-HSA-8866654|reactome:R-HSA-9033241|reactome:R-HSA-9603798|refseq:NP_000309.1|refseq:NP_001073336.1|refseq:NP_001165557.1|refseq:NP_001165558.1	-	-	-	-	comment:Binds to exon 1, intron 1 and intron 3. Binding increases over a 12 hour time period following stimultation.|agonist:Doxorubicin|figure legend:Fig. 7C|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hct116)|taxid:9606(Human colon carcinoma HCT116 cells)	-	2009/06/01	2014/10/16	rogid:jRy3158OBvN/huC4vR4MSyMWuSg9606	-	intact-crc:A694097DEEE91BBA	false	-	-	-	-	psi-mi:"MI:0088"(primer specific pcr)	psi-mi:"MI:0088"(primer specific pcr)
uniprotkb:Q5VTR2	ensembl:ENSG00000124762	intact:EBI-2372238|uniprotkb:Q2TB34|uniprotkb:Q69YL5|uniprotkb:Q6P527|uniprotkb:Q8N3J4|uniprotkb:Q96JD3|uniprotkb:Q9H9Y7|uniprotkb:Q9HA51|uniprotkb:Q9NUR4|uniprotkb:Q9NWQ3|uniprotkb:Q9NX83|uniprotkb:A7MCT5|ensembl:ENSP00000373772	intact:EBI-1550784	psi-mi:bre1a_human(display_long)|uniprotkb:RNF20(gene name)|psi-mi:RNF20(display_short)|uniprotkb:BRE1A(gene name synonym)|uniprotkb:RING finger protein 20(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BRE1A(gene name synonym)	psi-mi:cdkn1a_human_gene(display_short)|psi-mi:ENSG00000124762(display_long)	psi-mi:"MI:0402"(chromatin immunoprecipitation assay)	Kim et al. (2009)	imex:IM-12178|pubmed:19410543	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2411153|imex:IM-12178-21	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0250"(gene)	refseq:XP_011517164.1|refseq:NP_062538.5|dip:DIP-53411N|ensembl:ENSG00000155827(gene)|ensembl:ENST00000389120(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0002039"(p53 binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0031062"(positive regulation of histone methylation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033503"(HULC complex)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0042393"(histone binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:1900364"(negative regulation of mRNA polyadenylation)|go:"GO:2001168"(positive regulation of histone H2B ubiquitination)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013956(E3 ubiquitin ligase, BRE1)|interpro:IPR017907|mint:Q5VTR2|rcsb pdb:5TRB|reactome:R-HSA-8866654|reactome:R-HSA-9013422	-	-	-	-	comment:Binds multiple regions in the CDKN1A gene. Binding increases over a 12 hour time period following stimultation.|agonist:Doxorubicin|figure legend:Fig. 7C|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hct116)|taxid:9606(Human colon carcinoma HCT116 cells)	-	2009/06/01	2014/10/16	rogid:zscBhEtpu0D69sPn1wXsEGBIiOY9606	-	intact-crc:D053ED18D63BF94D	false	-	-	-	-	psi-mi:"MI:0088"(primer specific pcr)	psi-mi:"MI:0088"(primer specific pcr)
uniprotkb:P51965	ensembl:ENSG00000124762	intact:EBI-348546|uniprotkb:B2RBX4|ensembl:ENSP00000303709|uniprotkb:C9J8K2|uniprotkb:K4DI90	intact:EBI-1550784	psi-mi:ub2e1_human(display_long)|uniprotkb:UBE2E1(gene name)|psi-mi:UBE2E1(display_short)|uniprotkb:UBCH6(gene name synonym)|uniprotkb:Ubiquitin-protein ligase E1(gene name synonym)|uniprotkb:Ubiquitin carrier protein E1(gene name synonym)|uniprotkb:UbcH6(gene name synonym)|uniprotkb:"(E3-independent) E2 ubiquitin-conjugating enzyme E1"(gene name synonym)|uniprotkb:E2 ubiquitin-conjugating enzyme E1(gene name synonym)	psi-mi:cdkn1a_human_gene(display_short)|psi-mi:ENSG00000124762(display_long)	psi-mi:"MI:0402"(chromatin immunoprecipitation assay)	Kim et al. (2009)	imex:IM-12178|pubmed:19410543	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2411160|imex:IM-12178-22	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0250"(gene)	refseq:NP_003332.1|refseq:NP_872607.1|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|go:"GO:0070936"(protein K48-linked ubiquitination)|interpro:IPR023313|rcsb pdb:1XR9|rcsb pdb:3BZH|rcsb pdb:4JJQ|rcsb pdb:5LBN|rcsb pdb:6FGA|reactome:R-HSA-1169408|reactome:R-HSA-141430|reactome:R-HSA-174048|reactome:R-HSA-174084|reactome:R-HSA-174154|reactome:R-HSA-174178|reactome:R-HSA-174184|reactome:R-HSA-176407|reactome:R-HSA-176408|reactome:R-HSA-176409|reactome:R-HSA-176412|reactome:R-HSA-179409|reactome:R-HSA-2467813|reactome:R-HSA-2559582|reactome:R-HSA-69017|reactome:R-HSA-8853884|reactome:R-HSA-8866652|reactome:R-HSA-8866654|reactome:R-HSA-9687136|reactome:R-HSA-983168|ensembl:ENST00000306627(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032020"(ISG15-protein conjugation)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0042296"(ISG15 transferase activity)|go:"GO:0061631"(ubiquitin conjugating enzyme activity)|ensembl:ENSG00000170142(gene)|refseq:NP_001189405.1	-	-	-	-	comment:Binds multiple regions in the CDKN1A gene. Binding increases over a 2 hour time period, then decreases.|agonist:Doxorubicin|figure legend:Fig. 7C|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hct116)|taxid:9606(Human colon carcinoma HCT116 cells)	-	2009/06/01	2014/10/16	rogid:pPIqYniSQn5Jh7u5x0Lm2NXppQU9606	-	intact-crc:6767448902B6F188	false	-	-	-	-	psi-mi:"MI:0088"(primer specific pcr)	psi-mi:"MI:0088"(primer specific pcr)
uniprotkb:Q07457	uniprotkb:Q07457	intact:EBI-31563|uniprotkb:D6VRS5|ensemblfungi:YDL074C	intact:EBI-31563|uniprotkb:D6VRS5|ensemblfungi:YDL074C	psi-mi:bre1_yeast(display_long)|uniprotkb:BRE1(gene name)|psi-mi:BRE1(display_short)|uniprotkb:Brefeldin A-sensitivity protein 1(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BRE1(gene name synonym)|uniprotkb:YDL074C(locus name)	psi-mi:bre1_yeast(display_long)|uniprotkb:BRE1(gene name)|psi-mi:BRE1(display_short)|uniprotkb:Brefeldin A-sensitivity protein 1(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BRE1(gene name synonym)|uniprotkb:YDL074C(locus name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kim et al. (2009)	imex:IM-12178|pubmed:19410543	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2411220|imex:IM-12178-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_010209.1|sgd:S000002232|dip:DIP-2999N|mint:Q07457|ensemblfungi:YDL074C(gene)|ensemblfungi:YDL074C_mRNA(transcript)|go:"GO:0000722"(telomere maintenance via recombination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005634"(nucleus)|go:"GO:0006348"|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0030174"(regulation of DNA-dependent DNA replication initiation)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0042138"(meiotic DNA double-strand break formation)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR013956(E3 ubiquitin ligase, BRE1)|rcsb pdb:4R7E	refseq:NP_010209.1|sgd:S000002232|dip:DIP-2999N|mint:Q07457|ensemblfungi:YDL074C(gene)|ensemblfungi:YDL074C_mRNA(transcript)|go:"GO:0000722"(telomere maintenance via recombination)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0005634"(nucleus)|go:"GO:0006348"|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0030174"(regulation of DNA-dependent DNA replication initiation)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0042138"(meiotic DNA double-strand break formation)|go:"GO:0042802"(identical protein binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR013956(E3 ubiquitin ligase, BRE1)|rcsb pdb:4R7E	psi-mi:"MI:0469"(intact)	crc64:FC6B32825970D36F	crc64:FC6B32825970D36F	figure legend:Supp. Fig. 11|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7108(spofr-sf_9)|taxid:7108(Spodoptera frugiperda insect cells)	-	2009/06/01	2014/10/16	rogid:oDMRE2wudyOH91xTQ/+8jKN+0L0559292	rogid:oDMRE2wudyOH91xTQ/+8jKN+0L0559292	intact-crc:20EC208562993CB9|rigid:ekHZLvfswn97XS4SSDsnLu2ibpk	false	glutathione s tranferase tag:?-?	flag tag:?-?	-	-	psi-mi:"MI:0707"(anti tag immunostaining)	psi-mi:"MI:0707"(anti tag immunostaining)