#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:O54861	uniprotkb:Q8K5A9	intact:EBI-915580|uniprotkb:O35389|ensembl:ENSRNOP00000051102	intact:EBI-6985586|ensembl:ENSRNOP00000028416|uniprotkb:Q8K5A8|intact:MINT-7290480|uniprotkb:G3V8U7	psi-mi:sort_rat(display_long)|uniprotkb:Neurotensin receptor 3(gene name synonym)|uniprotkb:Glycoprotein 110(gene name synonym)|uniprotkb:Sort1(gene name)|psi-mi:Sort1(display_short)	psi-mi:nradd_rat(display_long)|uniprotkb:P75-like apoptosis-inducing death domain protein(gene name synonym)|uniprotkb:Plaidd(gene name synonym)|uniprotkb:Neurotrophin receptor homolog-2(gene name synonym)|uniprotkb:Neurotrophin receptor-alike death domain protein(gene name synonym)|uniprotkb:Nrh2(gene name synonym)|uniprotkb:Nradd(gene name)|psi-mi:Nradd(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kim et al. (2009)	pubmed:19407813|imex:IM-15489|mint:MINT-7290452|doi:10.1038/emboj.2009.118	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-6985580|mint:MINT-7290496|imex:IM-15489-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:619999|refseq:NP_113955.1|ensembl:ENSRNOG00000031814(gene)|ensembl:ENSRNOT00000049127(transcript)|go:"GO:0001503"(ossification)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005769"(early endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006622"(protein targeting to lysosome)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006892"(post-Golgi vesicle-mediated transport)|go:"GO:0006895"(Golgi to endosome transport)|go:"GO:0006897"(endocytosis)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010465"(nerve growth factor receptor activity)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0014902"(myotube differentiation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016050"(vesicle organization)|go:"GO:0016492"(G protein-coupled neurotensin receptor activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030379"(neurotensin receptor activity, non-G protein-coupled)|go:"GO:0030425"(dendrite)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032509"(endosome transport via multivesicular body sorting pathway)|go:"GO:0032580"(Golgi cisterna membrane)|go:"GO:0032868"(response to insulin)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0046323"(glucose import)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048227"(plasma membrane to endosome transport)|go:"GO:0048406"(nerve growth factor binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051005"(negative regulation of lipoprotein lipase activity)|go:"GO:0090160"(Golgi to lysosome transport)|go:"GO:1904037"(positive regulation of epithelial cell apoptotic process)|go:"GO:1905394"(retromer complex binding)|interpro:IPR006581(VPS10)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR031777|interpro:IPR031778|mint:O54861|reactome:R-RNO-432722|mint:MINT-7290499(identity)	refseq:XP_006243983.1|ensembl:ENSRNOG00000020936(gene)|ensembl:ENSRNOT00000028416(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005035"(death receptor activity)|go:"GO:0005166"(neurotrophin p75 receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0007420"(brain development)|go:"GO:0009986"(cell surface)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030027"(lamellipodium)|go:"GO:0032589"(neuron projection membrane)|go:"GO:0044298"(cell body membrane)|go:"GO:0048406"(nerve growth factor binding)|interpro:IPR000488(Death)|interpro:IPR011029(DEATH-like)|interpro:IPR041448|mint:Q8K5A9|rgd:708524|refseq:NP_640352.1|mint:MINT-7290500(identity)	-	-	comment:mint	comment:homomint|comment:mint|figure legend:f1b sf3b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-brain)|taxid:10116(Rattus norvegicus brain)	-	2009/10/09	2014/10/16	rogid:3DR0ZaBcQurHYvbpi0KIjQZ665010116	rogid:V/AdtRdnqWylcyCCbJywkD+eRSY10116	intact-crc:4006A703834C3492|rigid:lx6vXDvGacP7WzPS+yIwlK1zMfg	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O54861	uniprotkb:P07174	intact:EBI-915580|uniprotkb:O35389|ensembl:ENSRNOP00000051102	intact:EBI-1038810	psi-mi:sort_rat(display_long)|uniprotkb:Neurotensin receptor 3(gene name synonym)|uniprotkb:Glycoprotein 110(gene name synonym)|uniprotkb:Sort1(gene name)|psi-mi:Sort1(display_short)	psi-mi:tnr16_rat(display_long)|uniprotkb:Ngfr(gene name)|psi-mi:Ngfr(display_short)|uniprotkb:Tnfrsf16(gene name synonym)|uniprotkb:Low-affinity nerve growth factor receptor(gene name synonym)|uniprotkb:Gp80-LNGFR(gene name synonym)|uniprotkb:p75 ICD(gene name synonym)|uniprotkb:Low affinity neurotrophin receptor p75NTR(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kim et al. (2009)	pubmed:19407813|imex:IM-15489|mint:MINT-7290452|doi:10.1038/emboj.2009.118	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-6985580|mint:MINT-7290496|imex:IM-15489-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:619999|refseq:NP_113955.1|ensembl:ENSRNOG00000031814(gene)|ensembl:ENSRNOT00000049127(transcript)|go:"GO:0001503"(ossification)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005769"(early endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006622"(protein targeting to lysosome)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006892"(post-Golgi vesicle-mediated transport)|go:"GO:0006895"(Golgi to endosome transport)|go:"GO:0006897"(endocytosis)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010465"(nerve growth factor receptor activity)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0014902"(myotube differentiation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016050"(vesicle organization)|go:"GO:0016492"(G protein-coupled neurotensin receptor activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030379"(neurotensin receptor activity, non-G protein-coupled)|go:"GO:0030425"(dendrite)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032509"(endosome transport via multivesicular body sorting pathway)|go:"GO:0032580"(Golgi cisterna membrane)|go:"GO:0032868"(response to insulin)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0046323"(glucose import)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048227"(plasma membrane to endosome transport)|go:"GO:0048406"(nerve growth factor binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051005"(negative regulation of lipoprotein lipase activity)|go:"GO:0090160"(Golgi to lysosome transport)|go:"GO:1904037"(positive regulation of epithelial cell apoptotic process)|go:"GO:1905394"(retromer complex binding)|interpro:IPR006581(VPS10)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR031777|interpro:IPR031778|mint:O54861|reactome:R-RNO-432722|mint:MINT-7290499(identity)	rgd:3177|refseq:NP_036742.2|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0005035"(death receptor activity)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0010941"(regulation of cell death)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0007165"(signal transduction)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0016048"(detection of temperature stimulus)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0021675"(nerve development)|go:"GO:0030135"(coated vesicle)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030426"(growth cone)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0007411"(axon guidance)|go:"GO:0007417"(central nervous system development)|go:"GO:0007623"(circadian rhythm)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031643"(positive regulation of myelination)|go:"GO:0032224"(positive regulation of synaptic transmission, cholinergic)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032590"(dendrite membrane)|go:"GO:0032809"(neuronal cell body membrane)|go:"GO:0009611"(response to wounding)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0009986"(cell surface)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0035907"(dorsal aorta development)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0040037"(negative regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0042488"(positive regulation of odontogenesis of dentin-containing tooth)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043121"(neurotrophin binding)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043588"(skin development)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048406"(nerve growth factor binding)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051799"(negative regulation of hair follicle development)|go:"GO:0051902"(negative regulation of mitochondrial depolarization)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0061000"(negative regulation of dendritic spine development)|go:"GO:0070678"(preprotein binding)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903588"(negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|interpro:IPR000488(Death)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR011029(DEATH-like)|interpro:IPR022325|interpro:IPR034046|interpro:IPR041448|rcsb pdb:1NGR|rcsb pdb:1SG1|rcsb pdb:2MIC|rcsb pdb:2MJO|rcsb pdb:3BUK|rcsb pdb:3IJ2|rcsb pdb:4F42|rcsb pdb:4F44|reactome:R-RNO-193634|reactome:R-RNO-193692|reactome:R-RNO-205017|reactome:R-RNO-205025|reactome:R-RNO-205043|reactome:R-RNO-209543|reactome:R-RNO-209560|reactome:R-RNO-209563|go:"GO:0051897"(positive regulation of protein kinase B signaling)|mint:P07174|dip:DIP-5715N|mint:MINT-7290498(identity)	-	-	-	comment:homomint|comment:mint|figure legend:f1b sf3b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-brain)|taxid:10116(Rattus norvegicus brain)	-	2009/10/09	2014/10/16	rogid:3DR0ZaBcQurHYvbpi0KIjQZ665010116	rogid:lscumOKfwxDCsoAs1EZfp6iFwz410116	intact-crc:4006A703834C3492|rigid:lx6vXDvGacP7WzPS+yIwlK1zMfg	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P07174	uniprotkb:Q8K5A9	intact:EBI-1038810	intact:EBI-6985586|ensembl:ENSRNOP00000028416|uniprotkb:Q8K5A8|intact:MINT-7290480|uniprotkb:G3V8U7	psi-mi:tnr16_rat(display_long)|uniprotkb:Ngfr(gene name)|psi-mi:Ngfr(display_short)|uniprotkb:Tnfrsf16(gene name synonym)|uniprotkb:Low-affinity nerve growth factor receptor(gene name synonym)|uniprotkb:Gp80-LNGFR(gene name synonym)|uniprotkb:p75 ICD(gene name synonym)|uniprotkb:Low affinity neurotrophin receptor p75NTR(gene name synonym)	psi-mi:nradd_rat(display_long)|uniprotkb:P75-like apoptosis-inducing death domain protein(gene name synonym)|uniprotkb:Plaidd(gene name synonym)|uniprotkb:Neurotrophin receptor homolog-2(gene name synonym)|uniprotkb:Neurotrophin receptor-alike death domain protein(gene name synonym)|uniprotkb:Nrh2(gene name synonym)|uniprotkb:Nradd(gene name)|psi-mi:Nradd(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kim et al. (2009)	pubmed:19407813|imex:IM-15489|mint:MINT-7290452|doi:10.1038/emboj.2009.118	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-6985624|mint:MINT-7290551|imex:IM-15489-10	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:3177|refseq:NP_036742.2|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0005035"(death receptor activity)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0010941"(regulation of cell death)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0007165"(signal transduction)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0016048"(detection of temperature stimulus)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0021675"(nerve development)|go:"GO:0030135"(coated vesicle)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030426"(growth cone)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0007411"(axon guidance)|go:"GO:0007417"(central nervous system development)|go:"GO:0007623"(circadian rhythm)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031643"(positive regulation of myelination)|go:"GO:0032224"(positive regulation of synaptic transmission, cholinergic)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032590"(dendrite membrane)|go:"GO:0032809"(neuronal cell body membrane)|go:"GO:0009611"(response to wounding)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0009986"(cell surface)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0035907"(dorsal aorta development)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0040037"(negative regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0042488"(positive regulation of odontogenesis of dentin-containing tooth)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043121"(neurotrophin binding)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043588"(skin development)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048406"(nerve growth factor binding)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051799"(negative regulation of hair follicle development)|go:"GO:0051902"(negative regulation of mitochondrial depolarization)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0061000"(negative regulation of dendritic spine development)|go:"GO:0070678"(preprotein binding)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903588"(negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|interpro:IPR000488(Death)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR011029(DEATH-like)|interpro:IPR022325|interpro:IPR034046|interpro:IPR041448|rcsb pdb:1NGR|rcsb pdb:1SG1|rcsb pdb:2MIC|rcsb pdb:2MJO|rcsb pdb:3BUK|rcsb pdb:3IJ2|rcsb pdb:4F42|rcsb pdb:4F44|reactome:R-RNO-193634|reactome:R-RNO-193692|reactome:R-RNO-205017|reactome:R-RNO-205025|reactome:R-RNO-205043|reactome:R-RNO-209543|reactome:R-RNO-209560|reactome:R-RNO-209563|go:"GO:0051897"(positive regulation of protein kinase B signaling)|mint:P07174|dip:DIP-5715N|mint:MINT-7290557(identity)	refseq:XP_006243983.1|ensembl:ENSRNOG00000020936(gene)|ensembl:ENSRNOT00000028416(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005035"(death receptor activity)|go:"GO:0005166"(neurotrophin p75 receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0007420"(brain development)|go:"GO:0009986"(cell surface)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030027"(lamellipodium)|go:"GO:0032589"(neuron projection membrane)|go:"GO:0044298"(cell body membrane)|go:"GO:0048406"(nerve growth factor binding)|interpro:IPR000488(Death)|interpro:IPR011029(DEATH-like)|interpro:IPR041448|mint:Q8K5A9|rgd:708524|refseq:NP_640352.1|mint:MINT-7290553(identity)	-	-	comment:mint	comment:homomint|comment:mint|figure legend:f1b sf3b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-brain)|taxid:10116(Rattus norvegicus brain)	-	2009/10/09	2014/10/16	rogid:lscumOKfwxDCsoAs1EZfp6iFwz410116	rogid:V/AdtRdnqWylcyCCbJywkD+eRSY10116	intact-crc:B53BEE9313F3401A|rigid:lx6vXDvGacP7WzPS+yIwlK1zMfg	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:P07174	uniprotkb:O54861	intact:EBI-1038810	intact:EBI-915580|uniprotkb:O35389|ensembl:ENSRNOP00000051102	psi-mi:tnr16_rat(display_long)|uniprotkb:Ngfr(gene name)|psi-mi:Ngfr(display_short)|uniprotkb:Tnfrsf16(gene name synonym)|uniprotkb:Low-affinity nerve growth factor receptor(gene name synonym)|uniprotkb:Gp80-LNGFR(gene name synonym)|uniprotkb:p75 ICD(gene name synonym)|uniprotkb:Low affinity neurotrophin receptor p75NTR(gene name synonym)	psi-mi:sort_rat(display_long)|uniprotkb:Neurotensin receptor 3(gene name synonym)|uniprotkb:Glycoprotein 110(gene name synonym)|uniprotkb:Sort1(gene name)|psi-mi:Sort1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kim et al. (2009)	pubmed:19407813|imex:IM-15489|mint:MINT-7290452|doi:10.1038/emboj.2009.118	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-6985624|mint:MINT-7290551|imex:IM-15489-10	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:3177|refseq:NP_036742.2|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0005035"(death receptor activity)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0010941"(regulation of cell death)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0007165"(signal transduction)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0016048"(detection of temperature stimulus)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0021675"(nerve development)|go:"GO:0030135"(coated vesicle)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030426"(growth cone)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0007411"(axon guidance)|go:"GO:0007417"(central nervous system development)|go:"GO:0007623"(circadian rhythm)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031643"(positive regulation of myelination)|go:"GO:0032224"(positive regulation of synaptic transmission, cholinergic)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032590"(dendrite membrane)|go:"GO:0032809"(neuronal cell body membrane)|go:"GO:0009611"(response to wounding)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0009986"(cell surface)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0035907"(dorsal aorta development)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0040037"(negative regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0042488"(positive regulation of odontogenesis of dentin-containing tooth)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043121"(neurotrophin binding)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043588"(skin development)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048406"(nerve growth factor binding)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051799"(negative regulation of hair follicle development)|go:"GO:0051902"(negative regulation of mitochondrial depolarization)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0061000"(negative regulation of dendritic spine development)|go:"GO:0070678"(preprotein binding)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1903588"(negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|interpro:IPR000488(Death)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR011029(DEATH-like)|interpro:IPR022325|interpro:IPR034046|interpro:IPR041448|rcsb pdb:1NGR|rcsb pdb:1SG1|rcsb pdb:2MIC|rcsb pdb:2MJO|rcsb pdb:3BUK|rcsb pdb:3IJ2|rcsb pdb:4F42|rcsb pdb:4F44|reactome:R-RNO-193634|reactome:R-RNO-193692|reactome:R-RNO-205017|reactome:R-RNO-205025|reactome:R-RNO-205043|reactome:R-RNO-209543|reactome:R-RNO-209560|reactome:R-RNO-209563|go:"GO:0051897"(positive regulation of protein kinase B signaling)|mint:P07174|dip:DIP-5715N|mint:MINT-7290557(identity)	rgd:619999|refseq:NP_113955.1|ensembl:ENSRNOG00000031814(gene)|ensembl:ENSRNOT00000049127(transcript)|go:"GO:0001503"(ossification)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005769"(early endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006622"(protein targeting to lysosome)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006892"(post-Golgi vesicle-mediated transport)|go:"GO:0006895"(Golgi to endosome transport)|go:"GO:0006897"(endocytosis)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010465"(nerve growth factor receptor activity)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0014902"(myotube differentiation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016050"(vesicle organization)|go:"GO:0016492"(G protein-coupled neurotensin receptor activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030379"(neurotensin receptor activity, non-G protein-coupled)|go:"GO:0030425"(dendrite)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032509"(endosome transport via multivesicular body sorting pathway)|go:"GO:0032580"(Golgi cisterna membrane)|go:"GO:0032868"(response to insulin)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0046323"(glucose import)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048227"(plasma membrane to endosome transport)|go:"GO:0048406"(nerve growth factor binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051005"(negative regulation of lipoprotein lipase activity)|go:"GO:0090160"(Golgi to lysosome transport)|go:"GO:1904037"(positive regulation of epithelial cell apoptotic process)|go:"GO:1905394"(retromer complex binding)|interpro:IPR006581(VPS10)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR031777|interpro:IPR031778|mint:O54861|reactome:R-RNO-432722|mint:MINT-7290555(identity)	-	-	-	comment:homomint|comment:mint|figure legend:f1b sf3b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10116(rat-brain)|taxid:10116(Rattus norvegicus brain)	-	2009/10/09	2014/10/16	rogid:lscumOKfwxDCsoAs1EZfp6iFwz410116	rogid:3DR0ZaBcQurHYvbpi0KIjQZ665010116	intact-crc:B53BEE9313F3401A|rigid:lx6vXDvGacP7WzPS+yIwlK1zMfg	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q6PHU5	uniprotkb:Q9Z0W1	intact:EBI-6985663|ensembl:ENSMUSP00000099692|uniprotkb:Q9QXW6|uniprotkb:A2AEE8|uniprotkb:Q8K043|uniprotkb:Q3UHE2|intact:MINT-4130555	intact:EBI-4411273|uniprotkb:Q8CFT3|ensembl:ENSMUSP00000000122	psi-mi:sort_mouse(display_long)|uniprotkb:Sort1(gene name)|psi-mi:Sort1(display_short)|uniprotkb:Neurotensin receptor 3(gene name synonym)	psi-mi:tnr16_mouse(display_long)|uniprotkb:Ngfr(gene name)|psi-mi:Ngfr(display_short)|uniprotkb:Tnfrsf16(gene name synonym)|uniprotkb:Low affinity neurotrophin receptor p75NTR(gene name synonym)|uniprotkb:Low-affinity nerve growth factor receptor(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Kim et al. (2009)	pubmed:19407813|imex:IM-15489|mint:MINT-7290452|doi:10.1038/emboj.2009.118	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-6985714|mint:MINT-7290589|imex:IM-15489-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000068747(gene)|ensembl:ENSMUST00000102632(transcript)|go:"GO:0001503"(ossification)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005769"(early endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006622"(protein targeting to lysosome)|rcsb pdb:5ZNN|reactome:R-MMU-432722|go:"GO:0006892"(post-Golgi vesicle-mediated transport)|go:"GO:0006895"(Golgi to endosome transport)|go:"GO:0006897"(endocytosis)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010465"(nerve growth factor receptor activity)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0014902"(myotube differentiation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016050"(vesicle organization)|go:"GO:0019899"(enzyme binding)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030379"(neurotensin receptor activity, non-G protein-coupled)|go:"GO:0030425"(dendrite)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032509"(endosome transport via multivesicular body sorting pathway)|go:"GO:0032580"(Golgi cisterna membrane)|go:"GO:0032868"(response to insulin)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0046323"(glucose import)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048227"(plasma membrane to endosome transport)|go:"GO:0048406"(nerve growth factor binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051005"(negative regulation of lipoprotein lipase activity)|go:"GO:0090160"(Golgi to lysosome transport)|go:"GO:1904037"(positive regulation of epithelial cell apoptotic process)|go:"GO:1905394"(retromer complex binding)|interpro:IPR006581(VPS10)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR031777|interpro:IPR031778|mint:Q6PHU5|rcsb pdb:5NMR|rcsb pdb:5NMT|rcsb pdb:5NNI|rcsb pdb:5NNJ|refseq:NP_064356.2|refseq:NP_001258528.1|dip:DIP-46095N|mint:MINT-7290595(identity)	refseq:NP_150086.2|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031643"(positive regulation of myelination)|go:"GO:0032224"(positive regulation of synaptic transmission, cholinergic)|go:"GO:0032590"(dendrite membrane)|go:"GO:0032809"(neuronal cell body membrane)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0035907"(dorsal aorta development)|go:"GO:0040037"(negative regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0042488"(positive regulation of odontogenesis of dentin-containing tooth)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043121"(neurotrophin binding)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043588"(skin development)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048406"(nerve growth factor binding)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051799"(negative regulation of hair follicle development)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051902"(negative regulation of mitochondrial depolarization)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0061000"(negative regulation of dendritic spine development)|go:"GO:0070678"(preprotein binding)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:0031267"(small GTPase binding)|ensembl:ENSMUSG00000000120(gene)|ensembl:ENSMUST00000000122(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0005035"(death receptor activity)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|interpro:IPR000488(Death)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR011029(DEATH-like)|interpro:IPR022325|interpro:IPR034046|interpro:IPR041448|mint:Q9Z0W1|reactome:R-MMU-193634|reactome:R-MMU-193692|reactome:R-MMU-205017|reactome:R-MMU-205025|reactome:R-MMU-205043|reactome:R-MMU-209543|reactome:R-MMU-209560|reactome:R-MMU-209563|go:"GO:1903588"(negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0007411"(axon guidance)|go:"GO:0007417"(central nervous system development)|go:"GO:0007623"(circadian rhythm)|go:"GO:0009611"(response to wounding)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010941"(regulation of cell death)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016048"(detection of temperature stimulus)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0021675"(nerve development)|go:"GO:0030135"(coated vesicle)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030426"(growth cone)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0005739"(mitochondrion)|mint:MINT-7290597(identity)	-	function:"Functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR). Also required for protein transport from the Golgi apparatus to the endosomes. Promotes neuronal apoptosis by mediating endocytosis of the proapoptotic precursor forms of BDNF (proBDNF) and NGFB (proNGFB). Also acts as a receptor for neurotensin. May promote mineralization of the extracellular matrix during osteogenic differentiation by scavenging extracellular LPL. Probably required in adipocytes for the formation of specialized storage vesicles containing the glucose transporter SLC2A4/GLUT4 (GLUT4 storage vesicles, or GSVs). These vesicles provide a stable pool of SLC2A4 and confer increased responsiveness to insulin. May also mediate transport from the endoplasmic reticulum to the Golgi"|comment:mint	-	figure legend:F1A|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-dorsal root ga)|taxid:10090(Mus musculus)	-	2009/10/09	2019/07/08	rogid:YWk1GufR/sfGvpibzo3UOxenP7s10090	rogid:fGGb/QZNuWJkmI1WqYyELFX3Vgs10090	intact-crc:4233B711255E162E|rigid:1kQCjGAieNNdpzQQ7HrVculSOAU	false	-	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:Q8CJ26	uniprotkb:Q6PHU5	intact:EBI-6985725|ensembl:ENSMUSP00000035069|uniprotkb:Q3TVC1|intact:MINT-7290501	intact:EBI-6985663|ensembl:ENSMUSP00000099692|uniprotkb:Q9QXW6|uniprotkb:A2AEE8|uniprotkb:Q8K043|uniprotkb:Q3UHE2|intact:MINT-4130555	psi-mi:nradd_mouse(display_long)|uniprotkb:Neurotrophin receptor homolog-2(gene name synonym)|uniprotkb:Neurotrophin receptor-alike death domain protein(gene name synonym)|uniprotkb:Nradd(gene name)|psi-mi:Nradd(display_short)	psi-mi:sort_mouse(display_long)|uniprotkb:Sort1(gene name)|psi-mi:Sort1(display_short)|uniprotkb:Neurotensin receptor 3(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Kim et al. (2009)	pubmed:19407813|imex:IM-15489|mint:MINT-7290452|doi:10.1038/emboj.2009.118	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-6985761|mint:MINT-7290615|imex:IM-15489-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR000488(Death)|interpro:IPR011029(DEATH-like)|interpro:IPR041448|mint:Q8CJ26|rcsb pdb:2IB1|rcsb pdb:6HJ7|ensembl:ENSMUSG00000032491(gene)|ensembl:ENSMUST00000035069(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005035"(death receptor activity)|go:"GO:0005166"(neurotrophin p75 receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0007420"(brain development)|go:"GO:0009986"(cell surface)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030027"(lamellipodium)|go:"GO:0032589"(neuron projection membrane)|go:"GO:0044298"(cell body membrane)|go:"GO:0048406"(nerve growth factor binding)|refseq:NP_080288.1|mint:MINT-7290617(identity)	ensembl:ENSMUSG00000068747(gene)|ensembl:ENSMUST00000102632(transcript)|go:"GO:0001503"(ossification)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005769"(early endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006622"(protein targeting to lysosome)|rcsb pdb:5ZNN|reactome:R-MMU-432722|go:"GO:0006892"(post-Golgi vesicle-mediated transport)|go:"GO:0006895"(Golgi to endosome transport)|go:"GO:0006897"(endocytosis)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010465"(nerve growth factor receptor activity)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0014902"(myotube differentiation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016050"(vesicle organization)|go:"GO:0019899"(enzyme binding)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030379"(neurotensin receptor activity, non-G protein-coupled)|go:"GO:0030425"(dendrite)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032509"(endosome transport via multivesicular body sorting pathway)|go:"GO:0032580"(Golgi cisterna membrane)|go:"GO:0032868"(response to insulin)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0046323"(glucose import)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048227"(plasma membrane to endosome transport)|go:"GO:0048406"(nerve growth factor binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051005"(negative regulation of lipoprotein lipase activity)|go:"GO:0090160"(Golgi to lysosome transport)|go:"GO:1904037"(positive regulation of epithelial cell apoptotic process)|go:"GO:1905394"(retromer complex binding)|interpro:IPR006581(VPS10)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR031777|interpro:IPR031778|mint:Q6PHU5|rcsb pdb:5NMR|rcsb pdb:5NMT|rcsb pdb:5NNI|rcsb pdb:5NNJ|refseq:NP_064356.2|refseq:NP_001258528.1|dip:DIP-46095N|mint:MINT-7290619(identity)	-	comment:mint	function:"Functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR). Also required for protein transport from the Golgi apparatus to the endosomes. Promotes neuronal apoptosis by mediating endocytosis of the proapoptotic precursor forms of BDNF (proBDNF) and NGFB (proNGFB). Also acts as a receptor for neurotensin. May promote mineralization of the extracellular matrix during osteogenic differentiation by scavenging extracellular LPL. Probably required in adipocytes for the formation of specialized storage vesicles containing the glucose transporter SLC2A4/GLUT4 (GLUT4 storage vesicles, or GSVs). These vesicles provide a stable pool of SLC2A4 and confer increased responsiveness to insulin. May also mediate transport from the endoplasmic reticulum to the Golgi"|comment:mint	figure legend:F1A|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-dorsal root ga)|taxid:10090(Mus musculus)	-	2009/10/09	2014/10/16	rogid:YfQbYaZ3tGUlE9CF3/bvhRMOvF010090	rogid:YWk1GufR/sfGvpibzo3UOxenP7s10090	intact-crc:EF405049A1A700F9|rigid:JLnacajL2UpN/K/jmbIJ7DwcDIA	false	-	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:Q8CJ26	uniprotkb:Q9Z0W1	intact:EBI-6985725|ensembl:ENSMUSP00000035069|uniprotkb:Q3TVC1|intact:MINT-7290501	intact:EBI-4411273|uniprotkb:Q8CFT3|ensembl:ENSMUSP00000000122	psi-mi:nradd_mouse(display_long)|uniprotkb:Neurotrophin receptor homolog-2(gene name synonym)|uniprotkb:Neurotrophin receptor-alike death domain protein(gene name synonym)|uniprotkb:Nradd(gene name)|psi-mi:Nradd(display_short)	psi-mi:tnr16_mouse(display_long)|uniprotkb:Ngfr(gene name)|psi-mi:Ngfr(display_short)|uniprotkb:Tnfrsf16(gene name synonym)|uniprotkb:Low affinity neurotrophin receptor p75NTR(gene name synonym)|uniprotkb:Low-affinity nerve growth factor receptor(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Kim et al. (2009)	pubmed:19407813|imex:IM-15489|mint:MINT-7290452|doi:10.1038/emboj.2009.118	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-6985750|mint:MINT-7290607|imex:IM-15489-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR000488(Death)|interpro:IPR011029(DEATH-like)|interpro:IPR041448|mint:Q8CJ26|rcsb pdb:2IB1|rcsb pdb:6HJ7|ensembl:ENSMUSG00000032491(gene)|ensembl:ENSMUST00000035069(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005035"(death receptor activity)|go:"GO:0005166"(neurotrophin p75 receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0007420"(brain development)|go:"GO:0009986"(cell surface)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030027"(lamellipodium)|go:"GO:0032589"(neuron projection membrane)|go:"GO:0044298"(cell body membrane)|go:"GO:0048406"(nerve growth factor binding)|refseq:NP_080288.1|mint:MINT-7290611(identity)	refseq:NP_150086.2|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031643"(positive regulation of myelination)|go:"GO:0032224"(positive regulation of synaptic transmission, cholinergic)|go:"GO:0032590"(dendrite membrane)|go:"GO:0032809"(neuronal cell body membrane)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0035907"(dorsal aorta development)|go:"GO:0040037"(negative regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0042488"(positive regulation of odontogenesis of dentin-containing tooth)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043121"(neurotrophin binding)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043588"(skin development)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048406"(nerve growth factor binding)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051799"(negative regulation of hair follicle development)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051902"(negative regulation of mitochondrial depolarization)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0061000"(negative regulation of dendritic spine development)|go:"GO:0070678"(preprotein binding)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:0031267"(small GTPase binding)|ensembl:ENSMUSG00000000120(gene)|ensembl:ENSMUST00000000122(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0005035"(death receptor activity)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|interpro:IPR000488(Death)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR011029(DEATH-like)|interpro:IPR022325|interpro:IPR034046|interpro:IPR041448|mint:Q9Z0W1|reactome:R-MMU-193634|reactome:R-MMU-193692|reactome:R-MMU-205017|reactome:R-MMU-205025|reactome:R-MMU-205043|reactome:R-MMU-209543|reactome:R-MMU-209560|reactome:R-MMU-209563|go:"GO:1903588"(negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0007411"(axon guidance)|go:"GO:0007417"(central nervous system development)|go:"GO:0007623"(circadian rhythm)|go:"GO:0009611"(response to wounding)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010941"(regulation of cell death)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016048"(detection of temperature stimulus)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0021675"(nerve development)|go:"GO:0030135"(coated vesicle)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030426"(growth cone)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0005739"(mitochondrion)|mint:MINT-7290609(identity)	-	comment:mint	-	figure legend:F1A|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-dorsal root ga)|taxid:10090(Mus musculus)	-	2009/10/09	2019/07/08	rogid:YfQbYaZ3tGUlE9CF3/bvhRMOvF010090	rogid:fGGb/QZNuWJkmI1WqYyELFX3Vgs10090	intact-crc:9E9203AF4F274BE1|rigid:j5rAoczdnRrpeKZvgDgU31kYMG4	false	-	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:Q9Z0W1	uniprotkb:Q6PHU5	intact:EBI-4411273|uniprotkb:Q8CFT3|ensembl:ENSMUSP00000000122	intact:EBI-6985663|ensembl:ENSMUSP00000099692|uniprotkb:Q9QXW6|uniprotkb:A2AEE8|uniprotkb:Q8K043|uniprotkb:Q3UHE2|intact:MINT-4130555	psi-mi:tnr16_mouse(display_long)|uniprotkb:Ngfr(gene name)|psi-mi:Ngfr(display_short)|uniprotkb:Tnfrsf16(gene name synonym)|uniprotkb:Low affinity neurotrophin receptor p75NTR(gene name synonym)|uniprotkb:Low-affinity nerve growth factor receptor(gene name synonym)	psi-mi:sort_mouse(display_long)|uniprotkb:Sort1(gene name)|psi-mi:Sort1(display_short)|uniprotkb:Neurotensin receptor 3(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kim et al. (2009)	pubmed:19407813|imex:IM-15489|mint:MINT-7290452|doi:10.1038/emboj.2009.118	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-6985846|mint:MINT-7290573|imex:IM-15489-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_150086.2|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031643"(positive regulation of myelination)|go:"GO:0032224"(positive regulation of synaptic transmission, cholinergic)|go:"GO:0032590"(dendrite membrane)|go:"GO:0032809"(neuronal cell body membrane)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0035907"(dorsal aorta development)|go:"GO:0040037"(negative regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0042488"(positive regulation of odontogenesis of dentin-containing tooth)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043121"(neurotrophin binding)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043588"(skin development)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048406"(nerve growth factor binding)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051799"(negative regulation of hair follicle development)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051902"(negative regulation of mitochondrial depolarization)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0061000"(negative regulation of dendritic spine development)|go:"GO:0070678"(preprotein binding)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:0031267"(small GTPase binding)|ensembl:ENSMUSG00000000120(gene)|ensembl:ENSMUST00000000122(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0005035"(death receptor activity)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|interpro:IPR000488(Death)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR011029(DEATH-like)|interpro:IPR022325|interpro:IPR034046|interpro:IPR041448|mint:Q9Z0W1|reactome:R-MMU-193634|reactome:R-MMU-193692|reactome:R-MMU-205017|reactome:R-MMU-205025|reactome:R-MMU-205043|reactome:R-MMU-209543|reactome:R-MMU-209560|reactome:R-MMU-209563|go:"GO:1903588"(negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0007411"(axon guidance)|go:"GO:0007417"(central nervous system development)|go:"GO:0007623"(circadian rhythm)|go:"GO:0009611"(response to wounding)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010941"(regulation of cell death)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016048"(detection of temperature stimulus)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0021675"(nerve development)|go:"GO:0030135"(coated vesicle)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030426"(growth cone)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0005739"(mitochondrion)|mint:MINT-7290575(identity)	ensembl:ENSMUSG00000068747(gene)|ensembl:ENSMUST00000102632(transcript)|go:"GO:0001503"(ossification)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005769"(early endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006622"(protein targeting to lysosome)|rcsb pdb:5ZNN|reactome:R-MMU-432722|go:"GO:0006892"(post-Golgi vesicle-mediated transport)|go:"GO:0006895"(Golgi to endosome transport)|go:"GO:0006897"(endocytosis)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010465"(nerve growth factor receptor activity)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0014902"(myotube differentiation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016050"(vesicle organization)|go:"GO:0019899"(enzyme binding)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030379"(neurotensin receptor activity, non-G protein-coupled)|go:"GO:0030425"(dendrite)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032509"(endosome transport via multivesicular body sorting pathway)|go:"GO:0032580"(Golgi cisterna membrane)|go:"GO:0032868"(response to insulin)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0046323"(glucose import)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048227"(plasma membrane to endosome transport)|go:"GO:0048406"(nerve growth factor binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051005"(negative regulation of lipoprotein lipase activity)|go:"GO:0090160"(Golgi to lysosome transport)|go:"GO:1904037"(positive regulation of epithelial cell apoptotic process)|go:"GO:1905394"(retromer complex binding)|interpro:IPR006581(VPS10)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR031777|interpro:IPR031778|mint:Q6PHU5|rcsb pdb:5NMR|rcsb pdb:5NMT|rcsb pdb:5NNI|rcsb pdb:5NNJ|refseq:NP_064356.2|refseq:NP_001258528.1|dip:DIP-46095N|mint:MINT-7290579(identity)	-	-	function:"Functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR). Also required for protein transport from the Golgi apparatus to the endosomes. Promotes neuronal apoptosis by mediating endocytosis of the proapoptotic precursor forms of BDNF (proBDNF) and NGFB (proNGFB). Also acts as a receptor for neurotensin. May promote mineralization of the extracellular matrix during osteogenic differentiation by scavenging extracellular LPL. Probably required in adipocytes for the formation of specialized storage vesicles containing the glucose transporter SLC2A4/GLUT4 (GLUT4 storage vesicles, or GSVs). These vesicles provide a stable pool of SLC2A4 and confer increased responsiveness to insulin. May also mediate transport from the endoplasmic reticulum to the Golgi"|comment:mint	figure legend:F2B|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2009/10/09	2019/07/08	rogid:fGGb/QZNuWJkmI1WqYyELFX3Vgs10090	rogid:YWk1GufR/sfGvpibzo3UOxenP7s10090	intact-crc:E123AC82C7ED2C1A|rigid:gxmZLZZ0aIBKbWPS7teGXQ3/aZs	false	ha tag:?-?(MINT-7290576)	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9Z0W1	uniprotkb:Q8CJ26	intact:EBI-4411273|uniprotkb:Q8CFT3|ensembl:ENSMUSP00000000122	intact:EBI-6985725|ensembl:ENSMUSP00000035069|uniprotkb:Q3TVC1|intact:MINT-7290501	psi-mi:tnr16_mouse(display_long)|uniprotkb:Ngfr(gene name)|psi-mi:Ngfr(display_short)|uniprotkb:Tnfrsf16(gene name synonym)|uniprotkb:Low affinity neurotrophin receptor p75NTR(gene name synonym)|uniprotkb:Low-affinity nerve growth factor receptor(gene name synonym)	psi-mi:nradd_mouse(display_long)|uniprotkb:Neurotrophin receptor homolog-2(gene name synonym)|uniprotkb:Neurotrophin receptor-alike death domain protein(gene name synonym)|uniprotkb:Nradd(gene name)|psi-mi:Nradd(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kim et al. (2009)	pubmed:19407813|imex:IM-15489|mint:MINT-7290452|doi:10.1038/emboj.2009.118	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-6985846|mint:MINT-7290573|imex:IM-15489-3	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_150086.2|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031643"(positive regulation of myelination)|go:"GO:0032224"(positive regulation of synaptic transmission, cholinergic)|go:"GO:0032590"(dendrite membrane)|go:"GO:0032809"(neuronal cell body membrane)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0035907"(dorsal aorta development)|go:"GO:0040037"(negative regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0042488"(positive regulation of odontogenesis of dentin-containing tooth)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043121"(neurotrophin binding)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043588"(skin development)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048406"(nerve growth factor binding)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051799"(negative regulation of hair follicle development)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051902"(negative regulation of mitochondrial depolarization)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0061000"(negative regulation of dendritic spine development)|go:"GO:0070678"(preprotein binding)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:0031267"(small GTPase binding)|ensembl:ENSMUSG00000000120(gene)|ensembl:ENSMUST00000000122(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0005035"(death receptor activity)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|interpro:IPR000488(Death)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR011029(DEATH-like)|interpro:IPR022325|interpro:IPR034046|interpro:IPR041448|mint:Q9Z0W1|reactome:R-MMU-193634|reactome:R-MMU-193692|reactome:R-MMU-205017|reactome:R-MMU-205025|reactome:R-MMU-205043|reactome:R-MMU-209543|reactome:R-MMU-209560|reactome:R-MMU-209563|go:"GO:1903588"(negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0007411"(axon guidance)|go:"GO:0007417"(central nervous system development)|go:"GO:0007623"(circadian rhythm)|go:"GO:0009611"(response to wounding)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010941"(regulation of cell death)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016048"(detection of temperature stimulus)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0021675"(nerve development)|go:"GO:0030135"(coated vesicle)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030426"(growth cone)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0005739"(mitochondrion)|mint:MINT-7290575(identity)	interpro:IPR000488(Death)|interpro:IPR011029(DEATH-like)|interpro:IPR041448|mint:Q8CJ26|rcsb pdb:2IB1|rcsb pdb:6HJ7|ensembl:ENSMUSG00000032491(gene)|ensembl:ENSMUST00000035069(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005035"(death receptor activity)|go:"GO:0005166"(neurotrophin p75 receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0007420"(brain development)|go:"GO:0009986"(cell surface)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030027"(lamellipodium)|go:"GO:0032589"(neuron projection membrane)|go:"GO:0044298"(cell body membrane)|go:"GO:0048406"(nerve growth factor binding)|refseq:NP_080288.1|mint:MINT-7290581(identity)	-	-	comment:mint	figure legend:F2B|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2009/10/09	2019/07/08	rogid:fGGb/QZNuWJkmI1WqYyELFX3Vgs10090	rogid:YfQbYaZ3tGUlE9CF3/bvhRMOvF010090	intact-crc:E123AC82C7ED2C1A|rigid:gxmZLZZ0aIBKbWPS7teGXQ3/aZs	false	ha tag:?-?(MINT-7290576)	flag tag:?-?(MINT-7290582)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q8CJ26	uniprotkb:Q6PHU5	intact:EBI-6985725|ensembl:ENSMUSP00000035069|uniprotkb:Q3TVC1|intact:MINT-7290501	intact:EBI-6985663|ensembl:ENSMUSP00000099692|uniprotkb:Q9QXW6|uniprotkb:A2AEE8|uniprotkb:Q8K043|uniprotkb:Q3UHE2|intact:MINT-4130555	psi-mi:nradd_mouse(display_long)|uniprotkb:Neurotrophin receptor homolog-2(gene name synonym)|uniprotkb:Neurotrophin receptor-alike death domain protein(gene name synonym)|uniprotkb:Nradd(gene name)|psi-mi:Nradd(display_short)	psi-mi:sort_mouse(display_long)|uniprotkb:Sort1(gene name)|psi-mi:Sort1(display_short)|uniprotkb:Neurotensin receptor 3(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kim et al. (2009)	pubmed:19407813|imex:IM-15489|mint:MINT-7290452|doi:10.1038/emboj.2009.118	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-6985811|mint:MINT-7290517|imex:IM-15489-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR000488(Death)|interpro:IPR011029(DEATH-like)|interpro:IPR041448|mint:Q8CJ26|rcsb pdb:2IB1|rcsb pdb:6HJ7|ensembl:ENSMUSG00000032491(gene)|ensembl:ENSMUST00000035069(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005035"(death receptor activity)|go:"GO:0005166"(neurotrophin p75 receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0007420"(brain development)|go:"GO:0009986"(cell surface)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030027"(lamellipodium)|go:"GO:0032589"(neuron projection membrane)|go:"GO:0044298"(cell body membrane)|go:"GO:0048406"(nerve growth factor binding)|refseq:NP_080288.1|mint:MINT-7290519(identity)	ensembl:ENSMUSG00000068747(gene)|ensembl:ENSMUST00000102632(transcript)|go:"GO:0001503"(ossification)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005769"(early endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006622"(protein targeting to lysosome)|rcsb pdb:5ZNN|reactome:R-MMU-432722|go:"GO:0006892"(post-Golgi vesicle-mediated transport)|go:"GO:0006895"(Golgi to endosome transport)|go:"GO:0006897"(endocytosis)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010465"(nerve growth factor receptor activity)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0014902"(myotube differentiation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016050"(vesicle organization)|go:"GO:0019899"(enzyme binding)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030379"(neurotensin receptor activity, non-G protein-coupled)|go:"GO:0030425"(dendrite)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032509"(endosome transport via multivesicular body sorting pathway)|go:"GO:0032580"(Golgi cisterna membrane)|go:"GO:0032868"(response to insulin)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0046323"(glucose import)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048227"(plasma membrane to endosome transport)|go:"GO:0048406"(nerve growth factor binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051005"(negative regulation of lipoprotein lipase activity)|go:"GO:0090160"(Golgi to lysosome transport)|go:"GO:1904037"(positive regulation of epithelial cell apoptotic process)|go:"GO:1905394"(retromer complex binding)|interpro:IPR006581(VPS10)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR031777|interpro:IPR031778|mint:Q6PHU5|rcsb pdb:5NMR|rcsb pdb:5NMT|rcsb pdb:5NNI|rcsb pdb:5NNJ|refseq:NP_064356.2|refseq:NP_001258528.1|dip:DIP-46095N|mint:MINT-7290520(identity)	-	comment:mint	function:"Functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR). Also required for protein transport from the Golgi apparatus to the endosomes. Promotes neuronal apoptosis by mediating endocytosis of the proapoptotic precursor forms of BDNF (proBDNF) and NGFB (proNGFB). Also acts as a receptor for neurotensin. May promote mineralization of the extracellular matrix during osteogenic differentiation by scavenging extracellular LPL. Probably required in adipocytes for the formation of specialized storage vesicles containing the glucose transporter SLC2A4/GLUT4 (GLUT4 storage vesicles, or GSVs). These vesicles provide a stable pool of SLC2A4 and confer increased responsiveness to insulin. May also mediate transport from the endoplasmic reticulum to the Golgi"|comment:mint	figure legend:F2A|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2009/10/09	2019/07/08	rogid:YfQbYaZ3tGUlE9CF3/bvhRMOvF010090	rogid:YWk1GufR/sfGvpibzo3UOxenP7s10090	intact-crc:214241EBCD79E43A|rigid:gxmZLZZ0aIBKbWPS7teGXQ3/aZs	false	flag tag:?-?(MINT-7290569)	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8CJ26	uniprotkb:Q9Z0W1	intact:EBI-6985725|ensembl:ENSMUSP00000035069|uniprotkb:Q3TVC1|intact:MINT-7290501	intact:EBI-4411273|uniprotkb:Q8CFT3|ensembl:ENSMUSP00000000122	psi-mi:nradd_mouse(display_long)|uniprotkb:Neurotrophin receptor homolog-2(gene name synonym)|uniprotkb:Neurotrophin receptor-alike death domain protein(gene name synonym)|uniprotkb:Nradd(gene name)|psi-mi:Nradd(display_short)	psi-mi:tnr16_mouse(display_long)|uniprotkb:Ngfr(gene name)|psi-mi:Ngfr(display_short)|uniprotkb:Tnfrsf16(gene name synonym)|uniprotkb:Low affinity neurotrophin receptor p75NTR(gene name synonym)|uniprotkb:Low-affinity nerve growth factor receptor(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kim et al. (2009)	pubmed:19407813|imex:IM-15489|mint:MINT-7290452|doi:10.1038/emboj.2009.118	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-6985811|mint:MINT-7290517|imex:IM-15489-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR000488(Death)|interpro:IPR011029(DEATH-like)|interpro:IPR041448|mint:Q8CJ26|rcsb pdb:2IB1|rcsb pdb:6HJ7|ensembl:ENSMUSG00000032491(gene)|ensembl:ENSMUST00000035069(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005035"(death receptor activity)|go:"GO:0005166"(neurotrophin p75 receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0007420"(brain development)|go:"GO:0009986"(cell surface)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030027"(lamellipodium)|go:"GO:0032589"(neuron projection membrane)|go:"GO:0044298"(cell body membrane)|go:"GO:0048406"(nerve growth factor binding)|refseq:NP_080288.1|mint:MINT-7290519(identity)	refseq:NP_150086.2|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031643"(positive regulation of myelination)|go:"GO:0032224"(positive regulation of synaptic transmission, cholinergic)|go:"GO:0032590"(dendrite membrane)|go:"GO:0032809"(neuronal cell body membrane)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0035907"(dorsal aorta development)|go:"GO:0040037"(negative regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0042488"(positive regulation of odontogenesis of dentin-containing tooth)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043121"(neurotrophin binding)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043588"(skin development)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048406"(nerve growth factor binding)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051799"(negative regulation of hair follicle development)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051902"(negative regulation of mitochondrial depolarization)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0061000"(negative regulation of dendritic spine development)|go:"GO:0070678"(preprotein binding)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:0031267"(small GTPase binding)|ensembl:ENSMUSG00000000120(gene)|ensembl:ENSMUST00000000122(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0005035"(death receptor activity)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|interpro:IPR000488(Death)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR011029(DEATH-like)|interpro:IPR022325|interpro:IPR034046|interpro:IPR041448|mint:Q9Z0W1|reactome:R-MMU-193634|reactome:R-MMU-193692|reactome:R-MMU-205017|reactome:R-MMU-205025|reactome:R-MMU-205043|reactome:R-MMU-209543|reactome:R-MMU-209560|reactome:R-MMU-209563|go:"GO:1903588"(negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0007411"(axon guidance)|go:"GO:0007417"(central nervous system development)|go:"GO:0007623"(circadian rhythm)|go:"GO:0009611"(response to wounding)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010941"(regulation of cell death)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016048"(detection of temperature stimulus)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0021675"(nerve development)|go:"GO:0030135"(coated vesicle)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030426"(growth cone)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0005739"(mitochondrion)|mint:MINT-7290521(identity)	-	comment:mint	-	figure legend:F2A|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2009/10/09	2019/07/08	rogid:YfQbYaZ3tGUlE9CF3/bvhRMOvF010090	rogid:fGGb/QZNuWJkmI1WqYyELFX3Vgs10090	intact-crc:214241EBCD79E43A|rigid:gxmZLZZ0aIBKbWPS7teGXQ3/aZs	false	flag tag:?-?(MINT-7290569)	ha tag:?-?(MINT-7290563)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q6PHU5	uniprotkb:Q8CJ26	intact:EBI-6985663|ensembl:ENSMUSP00000099692|uniprotkb:Q9QXW6|uniprotkb:A2AEE8|uniprotkb:Q8K043|uniprotkb:Q3UHE2|intact:MINT-4130555	intact:EBI-6985725|ensembl:ENSMUSP00000035069|uniprotkb:Q3TVC1|intact:MINT-7290501	psi-mi:sort_mouse(display_long)|uniprotkb:Sort1(gene name)|psi-mi:Sort1(display_short)|uniprotkb:Neurotensin receptor 3(gene name synonym)	psi-mi:nradd_mouse(display_long)|uniprotkb:Neurotrophin receptor homolog-2(gene name synonym)|uniprotkb:Neurotrophin receptor-alike death domain protein(gene name synonym)|uniprotkb:Nradd(gene name)|psi-mi:Nradd(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kim et al. (2009)	pubmed:19407813|imex:IM-15489|mint:MINT-7290452|doi:10.1038/emboj.2009.118	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-6985885|mint:MINT-7290654|imex:IM-15489-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000068747(gene)|ensembl:ENSMUST00000102632(transcript)|go:"GO:0001503"(ossification)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005769"(early endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006622"(protein targeting to lysosome)|rcsb pdb:5ZNN|reactome:R-MMU-432722|go:"GO:0006892"(post-Golgi vesicle-mediated transport)|go:"GO:0006895"(Golgi to endosome transport)|go:"GO:0006897"(endocytosis)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010465"(nerve growth factor receptor activity)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0014902"(myotube differentiation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016050"(vesicle organization)|go:"GO:0019899"(enzyme binding)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030379"(neurotensin receptor activity, non-G protein-coupled)|go:"GO:0030425"(dendrite)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032509"(endosome transport via multivesicular body sorting pathway)|go:"GO:0032580"(Golgi cisterna membrane)|go:"GO:0032868"(response to insulin)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0046323"(glucose import)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048227"(plasma membrane to endosome transport)|go:"GO:0048406"(nerve growth factor binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051005"(negative regulation of lipoprotein lipase activity)|go:"GO:0090160"(Golgi to lysosome transport)|go:"GO:1904037"(positive regulation of epithelial cell apoptotic process)|go:"GO:1905394"(retromer complex binding)|interpro:IPR006581(VPS10)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR031777|interpro:IPR031778|mint:Q6PHU5|rcsb pdb:5NMR|rcsb pdb:5NMT|rcsb pdb:5NNI|rcsb pdb:5NNJ|refseq:NP_064356.2|refseq:NP_001258528.1|dip:DIP-46095N|mint:MINT-7290660(identity)	interpro:IPR000488(Death)|interpro:IPR011029(DEATH-like)|interpro:IPR041448|mint:Q8CJ26|rcsb pdb:2IB1|rcsb pdb:6HJ7|ensembl:ENSMUSG00000032491(gene)|ensembl:ENSMUST00000035069(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005035"(death receptor activity)|go:"GO:0005166"(neurotrophin p75 receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0007420"(brain development)|go:"GO:0009986"(cell surface)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030027"(lamellipodium)|go:"GO:0032589"(neuron projection membrane)|go:"GO:0044298"(cell body membrane)|go:"GO:0048406"(nerve growth factor binding)|refseq:NP_080288.1|mint:MINT-7290656(identity)	-	function:"Functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR). Also required for protein transport from the Golgi apparatus to the endosomes. Promotes neuronal apoptosis by mediating endocytosis of the proapoptotic precursor forms of BDNF (proBDNF) and NGFB (proNGFB). Also acts as a receptor for neurotensin. May promote mineralization of the extracellular matrix during osteogenic differentiation by scavenging extracellular LPL. Probably required in adipocytes for the formation of specialized storage vesicles containing the glucose transporter SLC2A4/GLUT4 (GLUT4 storage vesicles, or GSVs). These vesicles provide a stable pool of SLC2A4 and confer increased responsiveness to insulin. May also mediate transport from the endoplasmic reticulum to the Golgi"|comment:mint	comment:mint	figure legend:F3E|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2009/10/09	2014/10/16	rogid:YWk1GufR/sfGvpibzo3UOxenP7s10090	rogid:YfQbYaZ3tGUlE9CF3/bvhRMOvF010090	intact-crc:A1CE12ED47FB409A|rigid:JLnacajL2UpN/K/jmbIJ7DwcDIA	false	mutation disrupting interaction:?-?(MINT-7290666)|myc tag:?-?(MINT-7290664)	flag tag:?-?(MINT-7290657)	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q8CJ26	uniprotkb:Q6PHU5	intact:EBI-6985725|ensembl:ENSMUSP00000035069|uniprotkb:Q3TVC1|intact:MINT-7290501	intact:EBI-6985663|ensembl:ENSMUSP00000099692|uniprotkb:Q9QXW6|uniprotkb:A2AEE8|uniprotkb:Q8K043|uniprotkb:Q3UHE2|intact:MINT-4130555	psi-mi:nradd_mouse(display_long)|uniprotkb:Neurotrophin receptor homolog-2(gene name synonym)|uniprotkb:Neurotrophin receptor-alike death domain protein(gene name synonym)|uniprotkb:Nradd(gene name)|psi-mi:Nradd(display_short)	psi-mi:sort_mouse(display_long)|uniprotkb:Sort1(gene name)|psi-mi:Sort1(display_short)|uniprotkb:Neurotensin receptor 3(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kim et al. (2009)	pubmed:19407813|imex:IM-15489|mint:MINT-7290452|doi:10.1038/emboj.2009.118	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-6985866|mint:MINT-7290636|imex:IM-15489-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR000488(Death)|interpro:IPR011029(DEATH-like)|interpro:IPR041448|mint:Q8CJ26|rcsb pdb:2IB1|rcsb pdb:6HJ7|ensembl:ENSMUSG00000032491(gene)|ensembl:ENSMUST00000035069(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005035"(death receptor activity)|go:"GO:0005166"(neurotrophin p75 receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0007420"(brain development)|go:"GO:0009986"(cell surface)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030027"(lamellipodium)|go:"GO:0032589"(neuron projection membrane)|go:"GO:0044298"(cell body membrane)|go:"GO:0048406"(nerve growth factor binding)|refseq:NP_080288.1|mint:MINT-7290644(identity)	ensembl:ENSMUSG00000068747(gene)|ensembl:ENSMUST00000102632(transcript)|go:"GO:0001503"(ossification)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005769"(early endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006622"(protein targeting to lysosome)|rcsb pdb:5ZNN|reactome:R-MMU-432722|go:"GO:0006892"(post-Golgi vesicle-mediated transport)|go:"GO:0006895"(Golgi to endosome transport)|go:"GO:0006897"(endocytosis)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010465"(nerve growth factor receptor activity)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0014902"(myotube differentiation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016050"(vesicle organization)|go:"GO:0019899"(enzyme binding)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030379"(neurotensin receptor activity, non-G protein-coupled)|go:"GO:0030425"(dendrite)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032509"(endosome transport via multivesicular body sorting pathway)|go:"GO:0032580"(Golgi cisterna membrane)|go:"GO:0032868"(response to insulin)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0046323"(glucose import)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048227"(plasma membrane to endosome transport)|go:"GO:0048406"(nerve growth factor binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051005"(negative regulation of lipoprotein lipase activity)|go:"GO:0090160"(Golgi to lysosome transport)|go:"GO:1904037"(positive regulation of epithelial cell apoptotic process)|go:"GO:1905394"(retromer complex binding)|interpro:IPR006581(VPS10)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR031777|interpro:IPR031778|mint:Q6PHU5|rcsb pdb:5NMR|rcsb pdb:5NMT|rcsb pdb:5NNI|rcsb pdb:5NNJ|refseq:NP_064356.2|refseq:NP_001258528.1|dip:DIP-46095N|mint:MINT-7290642(identity)	-	comment:mint	function:"Functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR). Also required for protein transport from the Golgi apparatus to the endosomes. Promotes neuronal apoptosis by mediating endocytosis of the proapoptotic precursor forms of BDNF (proBDNF) and NGFB (proNGFB). Also acts as a receptor for neurotensin. May promote mineralization of the extracellular matrix during osteogenic differentiation by scavenging extracellular LPL. Probably required in adipocytes for the formation of specialized storage vesicles containing the glucose transporter SLC2A4/GLUT4 (GLUT4 storage vesicles, or GSVs). These vesicles provide a stable pool of SLC2A4 and confer increased responsiveness to insulin. May also mediate transport from the endoplasmic reticulum to the Golgi"|comment:mint	figure legend:F3C|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2009/10/09	2014/10/16	rogid:YfQbYaZ3tGUlE9CF3/bvhRMOvF010090	rogid:YWk1GufR/sfGvpibzo3UOxenP7s10090	intact-crc:623697739C0B9316|rigid:JLnacajL2UpN/K/jmbIJ7DwcDIA	false	mutation disrupting interaction:181-228(MINT-7293612)|flag tag:?-?(MINT-7290645)	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8CJ26	uniprotkb:Q6PHU5	intact:EBI-6985725|ensembl:ENSMUSP00000035069|uniprotkb:Q3TVC1|intact:MINT-7290501	intact:EBI-6985663|ensembl:ENSMUSP00000099692|uniprotkb:Q9QXW6|uniprotkb:A2AEE8|uniprotkb:Q8K043|uniprotkb:Q3UHE2|intact:MINT-4130555	psi-mi:nradd_mouse(display_long)|uniprotkb:Neurotrophin receptor homolog-2(gene name synonym)|uniprotkb:Neurotrophin receptor-alike death domain protein(gene name synonym)|uniprotkb:Nradd(gene name)|psi-mi:Nradd(display_short)	psi-mi:sort_mouse(display_long)|uniprotkb:Sort1(gene name)|psi-mi:Sort1(display_short)|uniprotkb:Neurotensin receptor 3(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Kim et al. (2009)	pubmed:19407813|imex:IM-15489|mint:MINT-7290452|doi:10.1038/emboj.2009.118	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-6985932|mint:MINT-7290623|imex:IM-15489-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR000488(Death)|interpro:IPR011029(DEATH-like)|interpro:IPR041448|mint:Q8CJ26|rcsb pdb:2IB1|rcsb pdb:6HJ7|ensembl:ENSMUSG00000032491(gene)|ensembl:ENSMUST00000035069(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005035"(death receptor activity)|go:"GO:0005166"(neurotrophin p75 receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0007420"(brain development)|go:"GO:0009986"(cell surface)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030027"(lamellipodium)|go:"GO:0032589"(neuron projection membrane)|go:"GO:0044298"(cell body membrane)|go:"GO:0048406"(nerve growth factor binding)|refseq:NP_080288.1|mint:MINT-7290627(identity)	ensembl:ENSMUSG00000068747(gene)|ensembl:ENSMUST00000102632(transcript)|go:"GO:0001503"(ossification)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005769"(early endosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006622"(protein targeting to lysosome)|rcsb pdb:5ZNN|reactome:R-MMU-432722|go:"GO:0006892"(post-Golgi vesicle-mediated transport)|go:"GO:0006895"(Golgi to endosome transport)|go:"GO:0006897"(endocytosis)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0010465"(nerve growth factor receptor activity)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0014902"(myotube differentiation)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016050"(vesicle organization)|go:"GO:0019899"(enzyme binding)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030140"(trans-Golgi network transport vesicle)|go:"GO:0030379"(neurotensin receptor activity, non-G protein-coupled)|go:"GO:0030425"(dendrite)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032509"(endosome transport via multivesicular body sorting pathway)|go:"GO:0032580"(Golgi cisterna membrane)|go:"GO:0032868"(response to insulin)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0046323"(glucose import)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048227"(plasma membrane to endosome transport)|go:"GO:0048406"(nerve growth factor binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051005"(negative regulation of lipoprotein lipase activity)|go:"GO:0090160"(Golgi to lysosome transport)|go:"GO:1904037"(positive regulation of epithelial cell apoptotic process)|go:"GO:1905394"(retromer complex binding)|interpro:IPR006581(VPS10)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR031777|interpro:IPR031778|mint:Q6PHU5|rcsb pdb:5NMR|rcsb pdb:5NMT|rcsb pdb:5NNI|rcsb pdb:5NNJ|refseq:NP_064356.2|refseq:NP_001258528.1|dip:DIP-46095N|mint:MINT-7290625(identity)	go:"GO:0009986"(cell surface)	comment:mint	function:"Functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR). Also required for protein transport from the Golgi apparatus to the endosomes. Promotes neuronal apoptosis by mediating endocytosis of the proapoptotic precursor forms of BDNF (proBDNF) and NGFB (proNGFB). Also acts as a receptor for neurotensin. May promote mineralization of the extracellular matrix during osteogenic differentiation by scavenging extracellular LPL. Probably required in adipocytes for the formation of specialized storage vesicles containing the glucose transporter SLC2A4/GLUT4 (GLUT4 storage vesicles, or GSVs). These vesicles provide a stable pool of SLC2A4 and confer increased responsiveness to insulin. May also mediate transport from the endoplasmic reticulum to the Golgi"|comment:mint	figure legend:F4D|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-ht1080)|taxid:9606(Homo sapiens HT1080 fribrosarcoma cell line)	-	2009/10/09	2014/10/16	rogid:YfQbYaZ3tGUlE9CF3/bvhRMOvF010090	rogid:YWk1GufR/sfGvpibzo3UOxenP7s10090	intact-crc:355B58915E4AB4AF|rigid:JLnacajL2UpN/K/jmbIJ7DwcDIA	false	flag tag:?-?(MINT-7290633)	-	-	-	psi-mi:"MI:0707"(anti tag immunostaining)	psi-mi:"MI:0422"(immunostaining)