#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:A2A5Z6	uniprotkb:Q9Y2G4	intact:EBI-2348309|uniprotkb:A2A5Z7|uniprotkb:Q5IRE6|ensembl:ENSMUSP00000090177|ensembl:ENSMUSP00000129269	intact:EBI-1054868|uniprotkb:Q9NU24|uniprotkb:Q9UFQ9|intact:EBI-1535971|uniprotkb:Q5JUJ4|uniprotkb:Q5JUJ5|uniprotkb:Q8IUQ8|uniprotkb:B3KUC3|ensembl:ENSP00000345767|ensembl:ENSP00000430985	psi-mi:smuf2_mouse(display_long)|uniprotkb:Smurf2(gene name)|psi-mi:Smurf2(display_short)|uniprotkb:SMAD ubiquitination regulatory factor 2(gene name synonym)|uniprotkb:SMAD-specific E3 ubiquitin-protein ligase 2(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase SMURF2(gene name synonym)	psi-mi:ankr6_human(display_long)|uniprotkb:ANKRD6(gene name)|psi-mi:ANKRD6(display_short)|uniprotkb:Diversin(gene name synonym)|uniprotkb:KIAA0957(gene name synonym)	psi-mi:"MI:0729"(luminescence based mammalian interactome mapping)	Narimatsu et al. (2009)	imex:IM-12177|pubmed:19379695	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2348293|imex:IM-12177-29	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079757.2|refseq:XP_006533999.1|ensembl:ENSMUSG00000018363(gene)|ensembl:ENSMUST00000092517(transcript)|ensembl:ENSMUST00000167787(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016607"(nuclear speck)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046332"(SMAD binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|reactome:R-MMU-201451|reactome:R-MMU-2173788|reactome:R-MMU-2173795|reactome:R-MMU-4608870|reactome:R-MMU-4641257|reactome:R-MMU-5632684|reactome:R-MMU-5689880|reactome:R-MMU-8941858|reactome:R-MMU-983168	refseq:XP_011533902.1|refseq:NP_001229738.1|refseq:NP_001229740.1|refseq:NP_001229742.1|refseq:NP_001229743.1|refseq:NP_055757.3|refseq:XP_005248738.1|ensembl:ENSG00000135299(gene)|ensembl:ENST00000339746(transcript)|ensembl:ENST00000522441(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:2000096"(positive regulation of Wnt signaling pathway, planar cell polarity pathway)|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR036770|dip:DIP-39375N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 3A, Supp. Table 4|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2009/05/28	2014/10/16	rogid:a+mJTESi3rlZ5TMmGrZSxYo5FkM10090	rogid:gssh93FR25yJHUEPngWpqX0h0tU9606	intact-crc:B1714BB79E07C179|rigid:maRY8SbfqOrV88YrMDkW01w3+2A	false	mutation:716-716|renilla luciferase protein tag:?-?	flag tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P51141	uniprotkb:A2A5Z6	intact:EBI-1538407|uniprotkb:Q60868|uniprotkb:Q3U2D3|ensembl:ENSMUSP00000030948|ensembl:ENSMUSP00000133137	intact:EBI-2348309|uniprotkb:A2A5Z7|uniprotkb:Q5IRE6|ensembl:ENSMUSP00000090177|ensembl:ENSMUSP00000129269	psi-mi:dvl1_mouse(display_long)|uniprotkb:Dvl1(gene name)|psi-mi:Dvl1(display_short)|uniprotkb:Dvl(gene name synonym)|uniprotkb:DSH homolog 1(gene name synonym)	psi-mi:smuf2_mouse(display_long)|uniprotkb:Smurf2(gene name)|psi-mi:Smurf2(display_short)|uniprotkb:SMAD ubiquitination regulatory factor 2(gene name synonym)|uniprotkb:SMAD-specific E3 ubiquitin-protein ligase 2(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase SMURF2(gene name synonym)	psi-mi:"MI:0729"(luminescence based mammalian interactome mapping)	Narimatsu et al. (2009)	imex:IM-12177|pubmed:19379695	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2348301|imex:IM-12177-25	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_034221.3|refseq:NP_001289271.1|dip:DIP-38263N|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0022007"(convergent extension involved in neural plate elongation)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0035176"(social behavior)|go:"GO:0035372"(protein localization to microtubule)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043113"(receptor clustering)|go:"GO:0043197"(dendritic spine)|go:"GO:0045202"(synapse)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048668"(collateral sprouting)|go:"GO:0048675"(axon extension)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0060029"(convergent extension involved in organogenesis)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0071340"(skeletal muscle acetylcholine-gated channel clustering)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0090179"(planar cell polarity pathway involved in neural tube closure)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099054"(presynapse assembly)|go:"GO:0099173"(postsynapse organization)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1903827"|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|interpro:IPR001158(DIX)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR003351(Dishevelled protein)|interpro:IPR008339(Dishevelled region)|interpro:IPR008340(Dishevelled-1 protein)|interpro:IPR015506(Dishevelled related protein)|interpro:IPR024580|interpro:IPR029071|interpro:IPR036034|interpro:IPR036388|interpro:IPR036390|interpro:IPR038207|rcsb pdb:1FSH|rcsb pdb:1MC7|rcsb pdb:2KAW|rcsb pdb:2MX6|rcsb pdb:3PZ8|reactome:R-MMU-201688|reactome:R-MMU-4086400|reactome:R-MMU-4641258|reactome:R-MMU-4641262|reactome:R-MMU-5663220|ensembl:ENSMUSG00000029071(gene)|ensembl:ENSMUST00000030948(transcript)|ensembl:ENSMUST00000168552(transcript)|go:"GO:0001505"(regulation of neurotransmitter levels)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005109"(frizzled binding)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007409"(axonogenesis)|go:"GO:0007411"(axon guidance)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015630"(microtubule cytoskeleton)	refseq:NP_079757.2|refseq:XP_006533999.1|ensembl:ENSMUSG00000018363(gene)|ensembl:ENSMUST00000092517(transcript)|ensembl:ENSMUST00000167787(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016607"(nuclear speck)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046332"(SMAD binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|reactome:R-MMU-201451|reactome:R-MMU-2173788|reactome:R-MMU-2173795|reactome:R-MMU-4608870|reactome:R-MMU-4641257|reactome:R-MMU-5632684|reactome:R-MMU-5689880|reactome:R-MMU-8941858|reactome:R-MMU-983168	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 3A, Supp. Table 4|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2009/05/28	2014/10/16	rogid:m61iD63WqE333GDlyLU6Mlnq50o10090	rogid:a+mJTESi3rlZ5TMmGrZSxYo5FkM10090	intact-crc:796B049AED12EC49|rigid:Hhef4rYW0HOCfqjlfXGw23TbXaY	false	flag tag:?-?	mutation decreasing interaction:716-716|renilla luciferase protein tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O14641	uniprotkb:A2A5Z6	intact:EBI-740850|ensembl:ENSP00000005340|uniprotkb:Q53XM0|uniprotkb:D3DTN3	intact:EBI-2348309|uniprotkb:A2A5Z7|uniprotkb:Q5IRE6|ensembl:ENSMUSP00000090177|ensembl:ENSMUSP00000129269	psi-mi:dvl2_human(display_long)|uniprotkb:DSH homolog 2(gene name synonym)|uniprotkb:DVL2(gene name)|psi-mi:DVL2(display_short)	psi-mi:smuf2_mouse(display_long)|uniprotkb:Smurf2(gene name)|psi-mi:Smurf2(display_short)|uniprotkb:SMAD ubiquitination regulatory factor 2(gene name synonym)|uniprotkb:SMAD-specific E3 ubiquitin-protein ligase 2(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase SMURF2(gene name synonym)	psi-mi:"MI:0729"(luminescence based mammalian interactome mapping)	Narimatsu et al. (2009)	imex:IM-12177|pubmed:19379695	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2348381|imex:IM-12177-24	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004413.1|ensembl:ENSG00000004975(gene)|ensembl:ENST00000005340(transcript)|go:"GO:0001843"(neural tube closure)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0005109"(frizzled binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007379"(segment specification)|go:"GO:0007507"(heart development)|go:"GO:0016235"(aggresome)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022007"(convergent extension involved in neural plate elongation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035567"(non-canonical Wnt signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0044340"(canonical Wnt signaling pathway involved in regulation of cell proliferation)|go:"GO:0045177"(apical part of cell)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0090179"(planar cell polarity pathway involved in neural tube closure)|go:"GO:0150012"(positive regulation of neuron projection arborization)|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|interpro:IPR001158(DIX)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR003351(Dishevelled protein)|interpro:IPR008339(Dishevelled region)|interpro:IPR008341(Dishevelled-2 region)|interpro:IPR015506(Dishevelled related protein)|interpro:IPR024580|interpro:IPR029071|interpro:IPR036034|interpro:IPR036388|interpro:IPR036390|interpro:IPR038207|mint:O14641|rcsb pdb:2REY|rcsb pdb:3CBX|rcsb pdb:3CBY|rcsb pdb:3CBZ|rcsb pdb:3CC0|rcsb pdb:4WIP|rcsb pdb:5LNP|rcsb pdb:5SUY|rcsb pdb:5SUZ|rcsb pdb:6IW3|rcsb pdb:6JCK|reactome:R-HSA-201681|reactome:R-HSA-201688|reactome:R-HSA-2028269|reactome:R-HSA-4086400|reactome:R-HSA-4608870|reactome:R-HSA-4641258|reactome:R-HSA-4641262|reactome:R-HSA-5099900|reactome:R-HSA-5368598|reactome:R-HSA-5663220|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-9673324|ensembl:ENSP00000005340|dip:DIP-34433N	refseq:NP_079757.2|refseq:XP_006533999.1|ensembl:ENSMUSG00000018363(gene)|ensembl:ENSMUST00000092517(transcript)|ensembl:ENSMUST00000167787(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016607"(nuclear speck)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046332"(SMAD binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|reactome:R-MMU-201451|reactome:R-MMU-2173788|reactome:R-MMU-2173795|reactome:R-MMU-4608870|reactome:R-MMU-4641257|reactome:R-MMU-5632684|reactome:R-MMU-5689880|reactome:R-MMU-8941858|reactome:R-MMU-983168	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 3A, Supp. Fig. 6C, Supp. Table 4|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2009/05/28	2014/10/16	rogid:2Vdc8oRnT4Mz/j+EXQXrL3AszOc9606	rogid:a+mJTESi3rlZ5TMmGrZSxYo5FkM10090	intact-crc:B04916A3617FEDCA|rigid:boP5WYQt/JVGQ11VY95WPG7taM4	false	mutation decreasing interaction:501-501|mutation decreasing interaction:499-499|flag tag:?-?	mutation decreasing interaction:716-716|renilla luciferase protein tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q92997	uniprotkb:A2A5Z6	intact:EBI-739789|uniprotkb:O14642|uniprotkb:Q13531|uniprotkb:Q8N5E9|uniprotkb:Q92607|uniprotkb:D3DNT0|intact:EBI-11081380|uniprotkb:B4E3E5|ensembl:ENSP00000316054	intact:EBI-2348309|uniprotkb:A2A5Z7|uniprotkb:Q5IRE6|ensembl:ENSMUSP00000090177|ensembl:ENSMUSP00000129269	psi-mi:dvl3_human(display_long)|uniprotkb:DVL3(gene name)|psi-mi:DVL3(display_short)|uniprotkb:KIAA0208(gene name synonym)|uniprotkb:DSH homolog 3(gene name synonym)	psi-mi:smuf2_mouse(display_long)|uniprotkb:Smurf2(gene name)|psi-mi:Smurf2(display_short)|uniprotkb:SMAD ubiquitination regulatory factor 2(gene name synonym)|uniprotkb:SMAD-specific E3 ubiquitin-protein ligase 2(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase SMURF2(gene name synonym)	psi-mi:"MI:0729"(luminescence based mammalian interactome mapping)	Narimatsu et al. (2009)	imex:IM-12177|pubmed:19379695	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2348391|imex:IM-12177-19	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004414.3|dip:DIP-34509N|ensembl:ENSG00000161202(gene)|ensembl:ENST00000313143(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005109"(frizzled binding)|go:"GO:0005829"(cytosol)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035567"(non-canonical Wnt signaling pathway)|go:"GO:0038031"(non-canonical Wnt signaling pathway via JNK cascade)|go:"GO:0042493"|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050821"(protein stabilization)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0090179"(planar cell polarity pathway involved in neural tube closure)|go:"GO:0150012"(positive regulation of neuron projection arborization)|go:"GO:1903827"|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|interpro:IPR001158(DIX)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR003351(Dishevelled protein)|interpro:IPR008339(Dishevelled region)|interpro:IPR008342(Dishevelled-3 protein, C-terminal)|interpro:IPR015506(Dishevelled related protein)|interpro:IPR024580|interpro:IPR029071|interpro:IPR036034|interpro:IPR036388|interpro:IPR036390|interpro:IPR038207|mint:Q92997|rcsb pdb:6V7O|rcsb pdb:6ZC6|rcsb pdb:6ZC8|reactome:R-HSA-201681|reactome:R-HSA-201688|reactome:R-HSA-4086400|reactome:R-HSA-4641258|reactome:R-HSA-4641262|reactome:R-HSA-5368598|reactome:R-HSA-5663220|reactome:R-HSA-9673324	refseq:NP_079757.2|refseq:XP_006533999.1|ensembl:ENSMUSG00000018363(gene)|ensembl:ENSMUST00000092517(transcript)|ensembl:ENSMUST00000167787(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016607"(nuclear speck)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046332"(SMAD binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|reactome:R-MMU-201451|reactome:R-MMU-2173788|reactome:R-MMU-2173795|reactome:R-MMU-4608870|reactome:R-MMU-4641257|reactome:R-MMU-5632684|reactome:R-MMU-5689880|reactome:R-MMU-8941858|reactome:R-MMU-983168	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 3A, Supp. Table 4|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2009/05/28	2014/10/16	rogid:yJ3YIp5IhvKTQwa3bK5yTjNyqXk9606	rogid:a+mJTESi3rlZ5TMmGrZSxYo5FkM10090	intact-crc:0BDD7E7F1FD8039D|rigid:nzU3TTdS6AZWyhg6O+WKnYQMcZg	false	flag tag:?-?	mutation decreasing interaction:716-716|renilla luciferase protein tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:A2A5Z6	uniprotkb:Q15717	intact:EBI-2348309|uniprotkb:A2A5Z7|uniprotkb:Q5IRE6|ensembl:ENSMUSP00000090177|ensembl:ENSMUSP00000129269	intact:EBI-374260|uniprotkb:Q9BTT1|ensembl:ENSP00000385269|ensembl:ENSP00000472197|intact:EBI-6190219|uniprotkb:B4DVB8|uniprotkb:Q53XN6	psi-mi:smuf2_mouse(display_long)|uniprotkb:Smurf2(gene name)|psi-mi:Smurf2(display_short)|uniprotkb:SMAD ubiquitination regulatory factor 2(gene name synonym)|uniprotkb:SMAD-specific E3 ubiquitin-protein ligase 2(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase SMURF2(gene name synonym)	psi-mi:elav1_human(display_long)|uniprotkb:ELAVL1(gene name)|psi-mi:ELAVL1(display_short)|uniprotkb:HUR(gene name synonym)|uniprotkb:Hu-antigen R(gene name synonym)	psi-mi:"MI:0729"(luminescence based mammalian interactome mapping)	Narimatsu et al. (2009)	imex:IM-12177|pubmed:19379695	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2348401|imex:IM-12177-18	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079757.2|refseq:XP_006533999.1|ensembl:ENSMUSG00000018363(gene)|ensembl:ENSMUST00000092517(transcript)|ensembl:ENSMUST00000167787(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016607"(nuclear speck)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046332"(SMAD binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|reactome:R-MMU-201451|reactome:R-MMU-2173788|reactome:R-MMU-2173795|reactome:R-MMU-4608870|reactome:R-MMU-4641257|reactome:R-MMU-5632684|reactome:R-MMU-5689880|reactome:R-MMU-8941858|reactome:R-MMU-983168	go:"GO:0006606"(protein import into nucleus)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0016020"(membrane)|go:"GO:0016441"(posttranscriptional gene silencing)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0035198"(miRNA binding)|go:"GO:0035925"(mRNA 3'-UTR AU-rich region binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0060965"(negative regulation of gene silencing by miRNA)|go:"GO:0070935"(3'-UTR-mediated mRNA stabilization)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|ensembl:ENSG00000066044(gene)|ensembl:ENST00000407627(transcript)|ensembl:ENST00000596459(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|refseq:NP_001410.2|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000036"(regulation of stem cell population maintenance)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR002343(Paraneoplastic encephalomyelitis antigen)|interpro:IPR006548(Splicing factor ELAV/HuD)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034775|interpro:IPR034996|interpro:IPR035979|mint:Q15717|rcsb pdb:3HI9|rcsb pdb:4ED5|rcsb pdb:4EGL|rcsb pdb:4FXV|rcsb pdb:5SZW|rcsb pdb:6G2K|rcsb pdb:6GC5|rcsb pdb:6GD1|rcsb pdb:6GD2|rcsb pdb:6GD3|reactome:R-HSA-450520|reactome:R-HSA-72163|dip:DIP-31291N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 3A, Supp. Table 4|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2009/05/28	2014/10/16	rogid:a+mJTESi3rlZ5TMmGrZSxYo5FkM10090	rogid:PciL5KuvP+2aUUv9cv7gWScgbw89606	intact-crc:9BDFB60117847C62|rigid:ray4AnQSkvZqG9PRYY7Kv1OSwfY	false	mutation decreasing interaction:716-716|renilla luciferase protein tag:?-?	flag tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8VE28	uniprotkb:A2A5Z6	intact:EBI-1538490|uniprotkb:Q3TYU5|uniprotkb:Q3UM34|uniprotkb:Q8C4J8|uniprotkb:Q91Y45|uniprotkb:Q9D7U9|ensembl:ENSMUSP00000022051	intact:EBI-2348309|uniprotkb:A2A5Z7|uniprotkb:Q5IRE6|ensembl:ENSMUSP00000090177|ensembl:ENSMUSP00000129269	psi-mi:nkd2_mouse(display_long)|uniprotkb:Nkd2(gene name)|psi-mi:Nkd2(display_short)	psi-mi:smuf2_mouse(display_long)|uniprotkb:Smurf2(gene name)|psi-mi:Smurf2(display_short)|uniprotkb:SMAD ubiquitination regulatory factor 2(gene name synonym)|uniprotkb:SMAD-specific E3 ubiquitin-protein ligase 2(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase SMURF2(gene name synonym)	psi-mi:"MI:0729"(luminescence based mammalian interactome mapping)	Narimatsu et al. (2009)	imex:IM-12177|pubmed:19379695	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2348411|imex:IM-12177-22	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_082462.3|refseq:NP_001334464.1|ensembl:ENSMUSG00000021567(gene)|ensembl:ENSMUST00000022051(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006887"(exocytosis)|go:"GO:0010954"(positive regulation of protein processing)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0019838"(growth factor binding)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032036"(myosin heavy chain binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0048210"(Golgi vesicle fusion to target membrane)|go:"GO:0051117"(ATPase binding)|go:"GO:0070382"(exocytic vesicle)|go:"GO:0071944"(cell periphery)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR040140	refseq:NP_079757.2|refseq:XP_006533999.1|ensembl:ENSMUSG00000018363(gene)|ensembl:ENSMUST00000092517(transcript)|ensembl:ENSMUST00000167787(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016607"(nuclear speck)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046332"(SMAD binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|reactome:R-MMU-201451|reactome:R-MMU-2173788|reactome:R-MMU-2173795|reactome:R-MMU-4608870|reactome:R-MMU-4641257|reactome:R-MMU-5632684|reactome:R-MMU-5689880|reactome:R-MMU-8941858|reactome:R-MMU-983168	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 3A, Supp. Table 4|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2009/05/28	2014/10/16	rogid:YahIfIwWuxWNCTmkeFs9nSf8UWc10090	rogid:a+mJTESi3rlZ5TMmGrZSxYo5FkM10090	intact-crc:6F08D391F2419985|rigid:CJxGexBEMze6agQZ/mrK6YtsUV4	false	flag tag:?-?	mutation decreasing interaction:716-716|renilla luciferase protein tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:A2A5Z6	uniprotkb:O75688	intact:EBI-2348309|uniprotkb:A2A5Z7|uniprotkb:Q5IRE6|ensembl:ENSMUSP00000090177|ensembl:ENSMUSP00000129269	intact:EBI-1047039|uniprotkb:Q9HAY8|uniprotkb:Q461Q2|uniprotkb:Q658R4|ensembl:ENSP00000282412|uniprotkb:Q96ER6|uniprotkb:Q4J6C1|uniprotkb:Q4J6C2	psi-mi:smuf2_mouse(display_long)|uniprotkb:Smurf2(gene name)|psi-mi:Smurf2(display_short)|uniprotkb:SMAD ubiquitination regulatory factor 2(gene name synonym)|uniprotkb:SMAD-specific E3 ubiquitin-protein ligase 2(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase SMURF2(gene name synonym)	psi-mi:ppm1b_human(display_long)|uniprotkb:Protein phosphatase 2C isoform beta(gene name synonym)|uniprotkb:PPM1B(gene name)|psi-mi:PPM1B(display_short)|uniprotkb:PP2CB(gene name synonym)	psi-mi:"MI:0729"(luminescence based mammalian interactome mapping)	Narimatsu et al. (2009)	imex:IM-12177|pubmed:19379695	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2348422|imex:IM-12177-20	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079757.2|refseq:XP_006533999.1|ensembl:ENSMUSG00000018363(gene)|ensembl:ENSMUST00000092517(transcript)|ensembl:ENSMUST00000167787(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016607"(nuclear speck)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046332"(SMAD binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|reactome:R-MMU-201451|reactome:R-MMU-2173788|reactome:R-MMU-2173795|reactome:R-MMU-4608870|reactome:R-MMU-4641257|reactome:R-MMU-5632684|reactome:R-MMU-5689880|reactome:R-MMU-8941858|reactome:R-MMU-983168	refseq:NP_001028729.1|refseq:NP_002697.1|refseq:NP_808907.1|refseq:NP_808908.1|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0050687"(negative regulation of defense response to virus)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|interpro:IPR000222(Protein phosphatase 2C,  manganese/magnesium aspartate binding site)|interpro:IPR001932(Protein phosphatase 2C-related)|interpro:IPR012911(Protein serine/threonine phosphatase 2C, C-terminal)|interpro:IPR036457|interpro:IPR036580|mint:O75688|rcsb pdb:2P8E|reactome:R-HSA-1169408|ensembl:ENSG00000138032(gene)|ensembl:ENST00000282412(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006499"(N-terminal protein myristoylation)|go:"GO:0016020"(membrane)|go:"GO:0030145"(manganese ion binding)|go:"GO:0032688"(negative regulation of interferon-beta production)|go:"GO:0035970"(peptidyl-threonine dephosphorylation)	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 3A, Supp. Table 4|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2009/05/28	2014/10/16	rogid:a+mJTESi3rlZ5TMmGrZSxYo5FkM10090	rogid:cwwfGSSTv9pR/XNLa9UxQ/6hpD89606	intact-crc:2A50E6107CD896C5|rigid:k8vpuBRW0qXnzlG9azjIn58mO1s	false	mutation decreasing interaction:716-716|renilla luciferase protein tag:?-?	flag tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P60484	uniprotkb:A2A5Z6	intact:EBI-696162|uniprotkb:O00633|uniprotkb:O02679|uniprotkb:Q6ICT7|uniprotkb:B2R904|uniprotkb:F2YHV0|ensembl:ENSP00000361021	intact:EBI-2348309|uniprotkb:A2A5Z7|uniprotkb:Q5IRE6|ensembl:ENSMUSP00000090177|ensembl:ENSMUSP00000129269	psi-mi:pten_human(display_long)|uniprotkb:Phosphatase and tensin homolog(gene name synonym)|uniprotkb:Mutated in multiple advanced cancers 1(gene name synonym)|uniprotkb:PTEN(gene name)|psi-mi:PTEN(display_short)|uniprotkb:MMAC1(gene name synonym)|uniprotkb:TEP1(gene name synonym)	psi-mi:smuf2_mouse(display_long)|uniprotkb:Smurf2(gene name)|psi-mi:Smurf2(display_short)|uniprotkb:SMAD ubiquitination regulatory factor 2(gene name synonym)|uniprotkb:SMAD-specific E3 ubiquitin-protein ligase 2(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase SMURF2(gene name synonym)	psi-mi:"MI:0729"(luminescence based mammalian interactome mapping)	Narimatsu et al. (2009)	imex:IM-12177|pubmed:19379695	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2348432|imex:IM-12177-27	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000305.3|refseq:NP_001291646.2|refseq:NP_001291647.1|dip:DIP-35019N|ensembl:ENSG00000171862(gene)|ensembl:ENST00000371953(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002902"(regulation of B cell apoptotic process)|go:"GO:0004438"(phosphatidylinositol-3-phosphatase activity)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007270"(neuron-neuron synaptic transmission)|go:"GO:0007416"(synapse assembly)|go:"GO:0007417"(central nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0007611"(learning or memory)|go:"GO:0007613"(memory)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008289"(lipid binding)|go:"GO:0009749"(response to glucose)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010043"(response to zinc ion)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0010719"(negative regulation of epithelial to mesenchymal transition)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0010997"(anaphase-promoting complex binding)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0014067"(negative regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014823"(response to activity)|go:"GO:0016311"(dephosphorylation)|go:"GO:0016314"(phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016605"(PML body)|go:"GO:0019899"(enzyme binding)|go:"GO:0021542"(dentate gyrus development)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030534"(adult behavior)|go:"GO:0031642"(negative regulation of myelination)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032228"(regulation of synaptic transmission, GABAergic)|go:"GO:0032286"(central nervous system myelin maintenance)|go:"GO:0032355"(response to estradiol)|go:"GO:0032535"(regulation of cellular component size)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033032"(regulation of myeloid cell apoptotic process)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0033198"(response to ATP)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0035176"(social behavior)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035749"(myelin sheath adaxonal region)|go:"GO:0042493"|go:"GO:0042711"(maternal behavior)|go:"GO:0042802"(identical protein binding)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043220"(Schmidt-Lanterman incisure)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046685"(response to arsenic-containing substance)|go:"GO:0046855"(inositol phosphate dephosphorylation)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0048681"(negative regulation of axon regeneration)|go:"GO:0048738"(cardiac muscle tissue development)|go:"GO:0048853"(forebrain morphogenesis)|go:"GO:0048854"(brain morphogenesis)|go:"GO:0048870"(cell motility)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050821"(protein stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051548"(negative regulation of keratinocyte migration)|go:"GO:0051717"(inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity)|go:"GO:0051800"(phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity)|go:"GO:0051895"(negative regulation of focal adhesion assembly)|go:"GO:0051896"(regulation of protein kinase B signaling)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0060024"(rhythmic synaptic transmission)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060074"(synapse maturation)|go:"GO:0060134"(prepulse inhibition)|go:"GO:0060179"(male mating behavior)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060736"(prostate gland growth)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061002"(negative regulation of dendritic spine morphogenesis)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071257"(cellular response to electrical stimulus)|go:"GO:0071361"(cellular response to ethanol)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0090071"(negative regulation of ribosome biogenesis)|go:"GO:0090344"(negative regulation of cell aging)|go:"GO:0090394"(negative regulation of excitatory postsynaptic potential)|go:"GO:0097105"(presynaptic membrane assembly)|go:"GO:0097107"(postsynaptic density assembly)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0106306"|go:"GO:0106307"|go:"GO:1901017"(negative regulation of potassium ion transmembrane transporter activity)|go:"GO:1902807"(negative regulation of cell cycle G1/S phase transition)|go:"GO:1903690"(negative regulation of wound healing, spreading of epidermal cells)|go:"GO:1903984"(positive regulation of TRAIL-activated apoptotic signaling pathway)|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:1990381"(ubiquitin-specific protease binding)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000272"(negative regulation of signaling receptor activity)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000808"(negative regulation of synaptic vesicle clustering)|interpro:IPR000340(Protein-tyrosine phosphatase, dual specificity)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR014020(C2 tensin-type)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR017361(Bifunctional phosphatidylinositol trisphosphate phosphatase/dual-specificity phosphatase PTEN)|interpro:IPR029021|interpro:IPR029023|interpro:IPR035892|mint:P60484|rcsb pdb:1D5R|rcsb pdb:2KYL|rcsb pdb:4O1V|rcsb pdb:5BUG|rcsb pdb:5BZX|rcsb pdb:5BZZ|reactome:R-HSA-1660499|reactome:R-HSA-1855204|reactome:R-HSA-199418|reactome:R-HSA-202424|reactome:R-HSA-5628897|reactome:R-HSA-5674404|reactome:R-HSA-5689880|reactome:R-HSA-5689896|reactome:R-HSA-8943723|reactome:R-HSA-8948747|reactome:R-HSA-8948751|reactome:R-HSA-8986944	refseq:NP_079757.2|refseq:XP_006533999.1|ensembl:ENSMUSG00000018363(gene)|ensembl:ENSMUST00000092517(transcript)|ensembl:ENSMUST00000167787(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016607"(nuclear speck)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046332"(SMAD binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|reactome:R-MMU-201451|reactome:R-MMU-2173788|reactome:R-MMU-2173795|reactome:R-MMU-4608870|reactome:R-MMU-4641257|reactome:R-MMU-5632684|reactome:R-MMU-5689880|reactome:R-MMU-8941858|reactome:R-MMU-983168	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 3A, Supp. Table 4|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2009/05/28	2014/10/16	rogid:/cPQox/hRcR/ED//46U5w4lcsyc9606	rogid:a+mJTESi3rlZ5TMmGrZSxYo5FkM10090	intact-crc:6B8EC88D1E6561DA|rigid:2EurO9EXqxbfFyJ3poew2Ez/bQE	false	flag tag:?-?	renilla luciferase protein tag:?-?|mutation decreasing interaction:716-716	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:A2A5Z6	uniprotkb:P63001	intact:EBI-2348309|uniprotkb:A2A5Z7|uniprotkb:Q5IRE6|ensembl:ENSMUSP00000090177|ensembl:ENSMUSP00000129269	intact:EBI-413646|ensembl:ENSMUSP00000079380|uniprotkb:O95501|uniprotkb:P15154|uniprotkb:Q9BTB4	psi-mi:smuf2_mouse(display_long)|uniprotkb:Smurf2(gene name)|psi-mi:Smurf2(display_short)|uniprotkb:SMAD ubiquitination regulatory factor 2(gene name synonym)|uniprotkb:SMAD-specific E3 ubiquitin-protein ligase 2(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase SMURF2(gene name synonym)	psi-mi:rac1_mouse(display_long)|uniprotkb:Rac1(gene name)|psi-mi:Rac1(display_short)|uniprotkb:p21-Rac1(gene name synonym)	psi-mi:"MI:0729"(luminescence based mammalian interactome mapping)	Narimatsu et al. (2009)	imex:IM-12177|pubmed:19379695	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2348442|imex:IM-12177-21	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079757.2|refseq:XP_006533999.1|ensembl:ENSMUSG00000018363(gene)|ensembl:ENSMUST00000092517(transcript)|ensembl:ENSMUST00000167787(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016607"(nuclear speck)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046332"(SMAD binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|reactome:R-MMU-201451|reactome:R-MMU-2173788|reactome:R-MMU-2173795|reactome:R-MMU-4608870|reactome:R-MMU-4641257|reactome:R-MMU-5632684|reactome:R-MMU-5689880|reactome:R-MMU-8941858|reactome:R-MMU-983168	go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002093"(auditory receptor cell morphogenesis)|go:"GO:0002551"(mast cell chemotaxis)|go:"GO:0003376"(sphingosine-1-phosphate receptor signaling pathway)|go:"GO:0003382"(epithelial cell morphogenesis)|ensembl:ENSMUSG00000001847(gene)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|ensembl:ENSMUST00000080537(transcript)|go:"GO:0005938"(cell cortex)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000242"(pericentriolar material)|go:"GO:0001764"(neuron migration)|go:"GO:0006897"(endocytosis)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006935"(chemotaxis)|go:"GO:0006972"(hyperosmotic response)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007015"(actin filament organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0001891"(phagocytic cup)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008361"(regulation of cell size)|go:"GO:0010591"(regulation of lamellipodium assembly)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010762"(regulation of fibroblast migration)|go:"GO:0010764"(negative regulation of fibroblast migration)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0014041"(regulation of neuron maturation)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0016477"(cell migration)|go:"GO:0007411"(axon guidance)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021799"(cerebral cortex radially oriented cell migration)|go:"GO:0021831"(embryonic olfactory bulb interneuron precursor migration)|go:"GO:0021894"(cerebral cortex GABAergic interneuron development)|go:"GO:0022604"(regulation of cell morphogenesis)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0030865"(cortical cytoskeleton organization)|go:"GO:0030900"(forebrain development)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031529"(ruffle organization)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032707"(negative regulation of interleukin-23 production)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035567"(non-canonical Wnt signaling pathway)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042470"(melanosome)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042995"(cell projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043652"(engulfment of apoptotic cell)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0045428"(regulation of nitric oxide biosynthetic process)|go:"GO:0045453"(bone resorption)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0046425"(regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048532"(anatomical structure arrangement)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0048870"(cell motility)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0051022"(Rho GDP-dissociation inhibitor binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051668"(localization within membrane)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0051932"(synaptic transmission, GABAergic)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0060091"(kinocilium)|go:"GO:0060263"(regulation of respiratory burst)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0048012"(hepatocyte growth factor receptor signaling pathway)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071526"(semaphorin-plexin signaling pathway)|go:"GO:0071542"(dopaminergic neuron differentiation)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0097178"(ruffle assembly)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902622"(regulation of neutrophil migration)|go:"GO:1904948"(midbrain dopaminergic neuron differentiation)|go:"GO:2000386"(positive regulation of ovarian follicle development)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|go:"GO:0061344"(regulation of cell adhesion involved in heart morphogenesis)|interpro:IPR027417|mint:P63001|reactome:R-MMU-114604|reactome:R-MMU-1257604|reactome:R-MMU-1433557|interpro:IPR005225(Small GTP-binding protein)|reactome:R-MMU-193648|reactome:R-MMU-2029482|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-376172|reactome:R-MMU-389359|reactome:R-MMU-3928662|reactome:R-MMU-3928664|reactome:R-MMU-3928665|reactome:R-MMU-399954|reactome:R-MMU-4086400|reactome:R-MMU-416550|reactome:R-MMU-5663213|reactome:R-MMU-418885|reactome:R-MMU-4420097|reactome:R-MMU-5663220|reactome:R-MMU-5668599|reactome:R-MMU-5687128|reactome:R-MMU-6798695|reactome:R-MMU-445144|reactome:R-MMU-6811558|reactome:R-MMU-8849471|reactome:R-MMU-8875555|reactome:R-MMU-9013149|reactome:R-MMU-9032759|reactome:R-MMU-983231|reactome:R-MMU-5218920|reactome:R-MMU-5625740|reactome:R-MMU-5625900|reactome:R-MMU-5625970|reactome:R-MMU-5626467|reactome:R-MMU-5627123|refseq:NP_033033.1|dip:DIP-31545N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 3A, Supp. Table 4|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2009/05/28	2014/10/16	rogid:a+mJTESi3rlZ5TMmGrZSxYo5FkM10090	rogid:8rkYyZSFL5tIfbRNKZgP/UDxD+A10090	intact-crc:E986E96D7344BFDA|rigid:PehkGXA/4A+cotjY9wrJhyWH84A	false	renilla luciferase protein tag:?-?|mutation decreasing interaction:716-716	flag tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P70399	uniprotkb:A2A5Z6	intact:EBI-769130|uniprotkb:Q68FD0|uniprotkb:Q8CI97|uniprotkb:Q91YC9|intact:EBI-11051502|intact:EBI-11516626|uniprotkb:A2AU89|uniprotkb:A2AU91|ensembl:ENSMUSP00000106278	intact:EBI-2348309|uniprotkb:A2A5Z7|uniprotkb:Q5IRE6|ensembl:ENSMUSP00000090177|ensembl:ENSMUSP00000129269	psi-mi:tp53b_mouse(display_long)|uniprotkb:Tp53bp1(gene name)|psi-mi:Tp53bp1(display_short)|uniprotkb:Trp53bp1(gene name synonym)	psi-mi:smuf2_mouse(display_long)|uniprotkb:Smurf2(gene name)|psi-mi:Smurf2(display_short)|uniprotkb:SMAD ubiquitination regulatory factor 2(gene name synonym)|uniprotkb:SMAD-specific E3 ubiquitin-protein ligase 2(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase SMURF2(gene name synonym)	psi-mi:"MI:0729"(luminescence based mammalian interactome mapping)	Narimatsu et al. (2009)	imex:IM-12177|pubmed:19379695	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2348452|imex:IM-12177-23	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001277759.1|refseq:NP_038763.3|dip:DIP-31595N|refseq:XP_011237883.1|ensembl:ENSMUSG00000043909(gene)|ensembl:ENSMUST00000110648(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000776"(kinetochore)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0002039"(p53 binding)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016604"(nuclear body)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0042393"(histone binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045830"(positive regulation of isotype switching)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0061649"(ubiquitin modification-dependent histone binding)|go:"GO:0071481"(cellular response to X-ray)|go:"GO:1990391"(DNA repair complex)|go:"GO:2000042"(negative regulation of double-strand break repair via homologous recombination)|interpro:IPR001357(BRCT)|interpro:IPR002999(Tudor)|interpro:IPR014722(Translation protein SH3-like, subgroup)|interpro:IPR015125(Tumour suppressor p53-binding protein-1 Tudor)|interpro:IPR036420|mint:P70399|rcsb pdb:1SSF|reactome:R-MMU-3232118|reactome:R-MMU-5693565|reactome:R-MMU-5693571|reactome:R-MMU-5693607|reactome:R-MMU-69473	refseq:NP_079757.2|refseq:XP_006533999.1|ensembl:ENSMUSG00000018363(gene)|ensembl:ENSMUST00000092517(transcript)|ensembl:ENSMUST00000167787(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016607"(nuclear speck)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046332"(SMAD binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|reactome:R-MMU-201451|reactome:R-MMU-2173788|reactome:R-MMU-2173795|reactome:R-MMU-4608870|reactome:R-MMU-4641257|reactome:R-MMU-5632684|reactome:R-MMU-5689880|reactome:R-MMU-8941858|reactome:R-MMU-983168	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 3A, Supp. Table 4|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2009/05/28	2017/05/26	rogid:z5tOHbR6ApNZRL9aptim/xRaVo010090	rogid:a+mJTESi3rlZ5TMmGrZSxYo5FkM10090	intact-crc:33AE49B06CB3D751|rigid:aLyaAeolXyOKwXRQdlJIsBruO9k	false	flag tag:?-?	renilla luciferase protein tag:?-?|mutation decreasing interaction:716-716	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O14641	uniprotkb:A2A5Z6	intact:EBI-740850|ensembl:ENSP00000005340|uniprotkb:Q53XM0|uniprotkb:D3DTN3	intact:EBI-2348309|uniprotkb:A2A5Z7|uniprotkb:Q5IRE6|ensembl:ENSMUSP00000090177|ensembl:ENSMUSP00000129269	psi-mi:dvl2_human(display_long)|uniprotkb:DSH homolog 2(gene name synonym)|uniprotkb:DVL2(gene name)|psi-mi:DVL2(display_short)	psi-mi:smuf2_mouse(display_long)|uniprotkb:Smurf2(gene name)|psi-mi:Smurf2(display_short)|uniprotkb:SMAD ubiquitination regulatory factor 2(gene name synonym)|uniprotkb:SMAD-specific E3 ubiquitin-protein ligase 2(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase SMURF2(gene name synonym)	psi-mi:"MI:0729"(luminescence based mammalian interactome mapping)	Narimatsu et al. (2009)	imex:IM-12177|pubmed:19379695	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2348462|imex:IM-12177-28	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004413.1|ensembl:ENSG00000004975(gene)|ensembl:ENST00000005340(transcript)|go:"GO:0001843"(neural tube closure)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0005109"(frizzled binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007379"(segment specification)|go:"GO:0007507"(heart development)|go:"GO:0016235"(aggresome)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022007"(convergent extension involved in neural plate elongation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035567"(non-canonical Wnt signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0044340"(canonical Wnt signaling pathway involved in regulation of cell proliferation)|go:"GO:0045177"(apical part of cell)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0090179"(planar cell polarity pathway involved in neural tube closure)|go:"GO:0150012"(positive regulation of neuron projection arborization)|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|interpro:IPR001158(DIX)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR003351(Dishevelled protein)|interpro:IPR008339(Dishevelled region)|interpro:IPR008341(Dishevelled-2 region)|interpro:IPR015506(Dishevelled related protein)|interpro:IPR024580|interpro:IPR029071|interpro:IPR036034|interpro:IPR036388|interpro:IPR036390|interpro:IPR038207|mint:O14641|rcsb pdb:2REY|rcsb pdb:3CBX|rcsb pdb:3CBY|rcsb pdb:3CBZ|rcsb pdb:3CC0|rcsb pdb:4WIP|rcsb pdb:5LNP|rcsb pdb:5SUY|rcsb pdb:5SUZ|rcsb pdb:6IW3|rcsb pdb:6JCK|reactome:R-HSA-201681|reactome:R-HSA-201688|reactome:R-HSA-2028269|reactome:R-HSA-4086400|reactome:R-HSA-4608870|reactome:R-HSA-4641258|reactome:R-HSA-4641262|reactome:R-HSA-5099900|reactome:R-HSA-5368598|reactome:R-HSA-5663220|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-9673324|ensembl:ENSP00000005340|dip:DIP-34433N	refseq:NP_079757.2|refseq:XP_006533999.1|ensembl:ENSMUSG00000018363(gene)|ensembl:ENSMUST00000092517(transcript)|ensembl:ENSMUST00000167787(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016607"(nuclear speck)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046332"(SMAD binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|reactome:R-MMU-201451|reactome:R-MMU-2173788|reactome:R-MMU-2173795|reactome:R-MMU-4608870|reactome:R-MMU-4641257|reactome:R-MMU-5632684|reactome:R-MMU-5689880|reactome:R-MMU-8941858|reactome:R-MMU-983168	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 3B|comment:Frizzled7 significantly enhanced Smurf2 interaction with Dvl2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2009/05/28	2014/10/16	rogid:2Vdc8oRnT4Mz/j+EXQXrL3AszOc9606	rogid:a+mJTESi3rlZ5TMmGrZSxYo5FkM10090	intact-crc:178C17AACB66AF71|rigid:boP5WYQt/JVGQ11VY95WPG7taM4	false	renilla luciferase protein tag:?-?	mutation decreasing interaction:716-716|flag tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O14641	uniprotkb:Q9CUN6	intact:EBI-740850|ensembl:ENSP00000005340|uniprotkb:Q53XM0|uniprotkb:D3DTN3	intact:EBI-2348474|uniprotkb:Q3U412|uniprotkb:Q8K300|ensembl:ENSMUSP00000082827	psi-mi:dvl2_human(display_long)|uniprotkb:DSH homolog 2(gene name synonym)|uniprotkb:DVL2(gene name)|psi-mi:DVL2(display_short)	psi-mi:smuf1_mouse(display_long)|uniprotkb:Smurf1(gene name)|psi-mi:Smurf1(display_short)|uniprotkb:SMAD ubiquitination regulatory factor 1(gene name synonym)|uniprotkb:SMAD-specific E3 ubiquitin-protein ligase 1(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase SMURF1(gene name synonym)	psi-mi:"MI:0729"(luminescence based mammalian interactome mapping)	Narimatsu et al. (2009)	imex:IM-12177|pubmed:19379695	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2348496|imex:IM-12177-26	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004413.1|ensembl:ENSG00000004975(gene)|ensembl:ENST00000005340(transcript)|go:"GO:0001843"(neural tube closure)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0005109"(frizzled binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007379"(segment specification)|go:"GO:0007507"(heart development)|go:"GO:0016235"(aggresome)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022007"(convergent extension involved in neural plate elongation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035567"(non-canonical Wnt signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0044340"(canonical Wnt signaling pathway involved in regulation of cell proliferation)|go:"GO:0045177"(apical part of cell)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0090179"(planar cell polarity pathway involved in neural tube closure)|go:"GO:0150012"(positive regulation of neuron projection arborization)|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|interpro:IPR001158(DIX)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR003351(Dishevelled protein)|interpro:IPR008339(Dishevelled region)|interpro:IPR008341(Dishevelled-2 region)|interpro:IPR015506(Dishevelled related protein)|interpro:IPR024580|interpro:IPR029071|interpro:IPR036034|interpro:IPR036388|interpro:IPR036390|interpro:IPR038207|mint:O14641|rcsb pdb:2REY|rcsb pdb:3CBX|rcsb pdb:3CBY|rcsb pdb:3CBZ|rcsb pdb:3CC0|rcsb pdb:4WIP|rcsb pdb:5LNP|rcsb pdb:5SUY|rcsb pdb:5SUZ|rcsb pdb:6IW3|rcsb pdb:6JCK|reactome:R-HSA-201681|reactome:R-HSA-201688|reactome:R-HSA-2028269|reactome:R-HSA-4086400|reactome:R-HSA-4608870|reactome:R-HSA-4641258|reactome:R-HSA-4641262|reactome:R-HSA-5099900|reactome:R-HSA-5368598|reactome:R-HSA-5663220|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-9673324|ensembl:ENSP00000005340|dip:DIP-34433N	refseq:NP_001033716.1|refseq:NP_083714.3|ensembl:ENSMUSG00000038780(gene)|ensembl:ENSMUST00000085684(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030154"(cell differentiation)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030424"(axon)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061734"(parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization)|go:"GO:0061736"(engulfment of target by autophagosome)|go:"GO:0061753"(substrate localization to autophagosome)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0071211"(protein targeting to vacuole involved in autophagy)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|mint:Q9CUN6|reactome:R-MMU-201451|reactome:R-MMU-2173791|reactome:R-MMU-4608870|reactome:R-MMU-5632684|reactome:R-MMU-8941858|reactome:R-MMU-983168	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 3B|comment:Frizzled7 significantly enhanced Smurf1 interaction with Dvl2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2009/05/28	2014/10/16	rogid:2Vdc8oRnT4Mz/j+EXQXrL3AszOc9606	rogid:e/0b1gSRRvjn9kLgSmd2PBRU8Eo10090	intact-crc:9D2BB2AEF871FB4B|rigid:rY+gzsUgPnt024+UyquF/phVjWw	false	renilla luciferase protein tag:?-?	flag tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O14641	uniprotkb:Q9Z101	intact:EBI-740850|ensembl:ENSP00000005340|uniprotkb:Q53XM0|uniprotkb:D3DTN3	intact:EBI-81732|uniprotkb:Q5RL03|uniprotkb:Q6P8R2|ensembl:ENSMUSP00000090886	psi-mi:dvl2_human(display_long)|uniprotkb:DSH homolog 2(gene name synonym)|uniprotkb:DVL2(gene name)|psi-mi:DVL2(display_short)	psi-mi:par6a_mouse(display_long)|uniprotkb:Pard6a(gene name)|psi-mi:Pard6a(display_short)|uniprotkb:Par6a(gene name synonym)	psi-mi:"MI:0729"(luminescence based mammalian interactome mapping)	Narimatsu et al. (2009)	imex:IM-12177|pubmed:19379695	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2348993|imex:IM-12177-30	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004413.1|ensembl:ENSG00000004975(gene)|ensembl:ENST00000005340(transcript)|go:"GO:0001843"(neural tube closure)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0005109"(frizzled binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007379"(segment specification)|go:"GO:0007507"(heart development)|go:"GO:0016235"(aggresome)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022007"(convergent extension involved in neural plate elongation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035567"(non-canonical Wnt signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0044340"(canonical Wnt signaling pathway involved in regulation of cell proliferation)|go:"GO:0045177"(apical part of cell)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0090179"(planar cell polarity pathway involved in neural tube closure)|go:"GO:0150012"(positive regulation of neuron projection arborization)|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|interpro:IPR001158(DIX)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR003351(Dishevelled protein)|interpro:IPR008339(Dishevelled region)|interpro:IPR008341(Dishevelled-2 region)|interpro:IPR015506(Dishevelled related protein)|interpro:IPR024580|interpro:IPR029071|interpro:IPR036034|interpro:IPR036388|interpro:IPR036390|interpro:IPR038207|mint:O14641|rcsb pdb:2REY|rcsb pdb:3CBX|rcsb pdb:3CBY|rcsb pdb:3CBZ|rcsb pdb:3CC0|rcsb pdb:4WIP|rcsb pdb:5LNP|rcsb pdb:5SUY|rcsb pdb:5SUZ|rcsb pdb:6IW3|rcsb pdb:6JCK|reactome:R-HSA-201681|reactome:R-HSA-201688|reactome:R-HSA-2028269|reactome:R-HSA-4086400|reactome:R-HSA-4608870|reactome:R-HSA-4641258|reactome:R-HSA-4641262|reactome:R-HSA-5099900|reactome:R-HSA-5368598|reactome:R-HSA-5663220|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-9673324|ensembl:ENSP00000005340|dip:DIP-34433N	refseq:NP_001040900.1|refseq:NP_062669.2|ensembl:ENSMUSG00000005699(gene)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0005938"(cell cortex)|ensembl:ENSMUST00000093195(transcript)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030054"(cell junction)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034451"(centriolar satellite)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045217"(cell-cell junction maintenance)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0051301"(cell division)|go:"GO:0060341"(regulation of cellular localization)|go:"GO:1904781"(positive regulation of protein localization to centrosome)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR034868|interpro:IPR034872|interpro:IPR036034|reactome:R-MMU-2173791|reactome:R-MMU-420029|reactome:R-MMU-4608870|reactome:R-MMU-9013148|reactome:R-MMU-9013149|dip:DIP-32553N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supp. Fig. 7A|caution:Exact coordinates of DOX or PDZ domains not given in text so region required to bind inferred from the UniProtKB entry.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2009/05/28	2014/10/16	rogid:2Vdc8oRnT4Mz/j+EXQXrL3AszOc9606	rogid:gmmbxc9dNybdFr3Tf6e8lN5H/vQ10090	intact-crc:D90F474FE1535613|rigid:gYfeDBQuuDBvl+CwKSz0nOEl7X0	false	flag tag:?-?|necessary binding region:94..94-267..267	renilla luciferase protein tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O14641	uniprotkb:A2A5Z6	intact:EBI-740850|ensembl:ENSP00000005340|uniprotkb:Q53XM0|uniprotkb:D3DTN3	intact:EBI-2348309|uniprotkb:A2A5Z7|uniprotkb:Q5IRE6|ensembl:ENSMUSP00000090177|ensembl:ENSMUSP00000129269	psi-mi:dvl2_human(display_long)|uniprotkb:DSH homolog 2(gene name synonym)|uniprotkb:DVL2(gene name)|psi-mi:DVL2(display_short)	psi-mi:smuf2_mouse(display_long)|uniprotkb:Smurf2(gene name)|psi-mi:Smurf2(display_short)|uniprotkb:SMAD ubiquitination regulatory factor 2(gene name synonym)|uniprotkb:SMAD-specific E3 ubiquitin-protein ligase 2(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase SMURF2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Narimatsu et al. (2009)	imex:IM-12177|pubmed:19379695	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2348512|imex:IM-12177-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004413.1|ensembl:ENSG00000004975(gene)|ensembl:ENST00000005340(transcript)|go:"GO:0001843"(neural tube closure)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0005109"(frizzled binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007379"(segment specification)|go:"GO:0007507"(heart development)|go:"GO:0016235"(aggresome)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022007"(convergent extension involved in neural plate elongation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035567"(non-canonical Wnt signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0044340"(canonical Wnt signaling pathway involved in regulation of cell proliferation)|go:"GO:0045177"(apical part of cell)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0090179"(planar cell polarity pathway involved in neural tube closure)|go:"GO:0150012"(positive regulation of neuron projection arborization)|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|interpro:IPR001158(DIX)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR003351(Dishevelled protein)|interpro:IPR008339(Dishevelled region)|interpro:IPR008341(Dishevelled-2 region)|interpro:IPR015506(Dishevelled related protein)|interpro:IPR024580|interpro:IPR029071|interpro:IPR036034|interpro:IPR036388|interpro:IPR036390|interpro:IPR038207|mint:O14641|rcsb pdb:2REY|rcsb pdb:3CBX|rcsb pdb:3CBY|rcsb pdb:3CBZ|rcsb pdb:3CC0|rcsb pdb:4WIP|rcsb pdb:5LNP|rcsb pdb:5SUY|rcsb pdb:5SUZ|rcsb pdb:6IW3|rcsb pdb:6JCK|reactome:R-HSA-201681|reactome:R-HSA-201688|reactome:R-HSA-2028269|reactome:R-HSA-4086400|reactome:R-HSA-4608870|reactome:R-HSA-4641258|reactome:R-HSA-4641262|reactome:R-HSA-5099900|reactome:R-HSA-5368598|reactome:R-HSA-5663220|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-9673324|ensembl:ENSP00000005340|dip:DIP-34433N	refseq:NP_079757.2|refseq:XP_006533999.1|ensembl:ENSMUSG00000018363(gene)|ensembl:ENSMUST00000092517(transcript)|ensembl:ENSMUST00000167787(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016607"(nuclear speck)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046332"(SMAD binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|reactome:R-MMU-201451|reactome:R-MMU-2173788|reactome:R-MMU-2173795|reactome:R-MMU-4608870|reactome:R-MMU-4641257|reactome:R-MMU-5632684|reactome:R-MMU-5689880|reactome:R-MMU-8941858|reactome:R-MMU-983168	psi-mi:"MI:0469"(intact)	-	-	figure legend:Figs. 3C, 3D, 3E|comment:Smurf2 preferentially associates with phosphorylated Dvl2|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2009/05/28	2014/10/16	rogid:2Vdc8oRnT4Mz/j+EXQXrL3AszOc9606	rogid:a+mJTESi3rlZ5TMmGrZSxYo5FkM10090	intact-crc:D12B961EEF61619B|rigid:boP5WYQt/JVGQ11VY95WPG7taM4	false	flag tag:?-?|mutation decreasing interaction:499-499	mutation:716-716|myc tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:A2A5Z6	uniprotkb:O14641	intact:EBI-2348309|uniprotkb:A2A5Z7|uniprotkb:Q5IRE6|ensembl:ENSMUSP00000090177|ensembl:ENSMUSP00000129269	intact:EBI-740850|ensembl:ENSP00000005340|uniprotkb:Q53XM0|uniprotkb:D3DTN3	psi-mi:smuf2_mouse(display_long)|uniprotkb:Smurf2(gene name)|psi-mi:Smurf2(display_short)|uniprotkb:SMAD ubiquitination regulatory factor 2(gene name synonym)|uniprotkb:SMAD-specific E3 ubiquitin-protein ligase 2(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase SMURF2(gene name synonym)	psi-mi:dvl2_human(display_long)|uniprotkb:DSH homolog 2(gene name synonym)|uniprotkb:DVL2(gene name)|psi-mi:DVL2(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Narimatsu et al. (2009)	imex:IM-12177|pubmed:19379695	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2348536|imex:IM-12177-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079757.2|refseq:XP_006533999.1|ensembl:ENSMUSG00000018363(gene)|ensembl:ENSMUST00000092517(transcript)|ensembl:ENSMUST00000167787(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016607"(nuclear speck)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046332"(SMAD binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|reactome:R-MMU-201451|reactome:R-MMU-2173788|reactome:R-MMU-2173795|reactome:R-MMU-4608870|reactome:R-MMU-4641257|reactome:R-MMU-5632684|reactome:R-MMU-5689880|reactome:R-MMU-8941858|reactome:R-MMU-983168	refseq:NP_004413.1|ensembl:ENSG00000004975(gene)|ensembl:ENST00000005340(transcript)|go:"GO:0001843"(neural tube closure)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0005109"(frizzled binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007379"(segment specification)|go:"GO:0007507"(heart development)|go:"GO:0016235"(aggresome)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022007"(convergent extension involved in neural plate elongation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035567"(non-canonical Wnt signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0044340"(canonical Wnt signaling pathway involved in regulation of cell proliferation)|go:"GO:0045177"(apical part of cell)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0090179"(planar cell polarity pathway involved in neural tube closure)|go:"GO:0150012"(positive regulation of neuron projection arborization)|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|interpro:IPR001158(DIX)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR003351(Dishevelled protein)|interpro:IPR008339(Dishevelled region)|interpro:IPR008341(Dishevelled-2 region)|interpro:IPR015506(Dishevelled related protein)|interpro:IPR024580|interpro:IPR029071|interpro:IPR036034|interpro:IPR036388|interpro:IPR036390|interpro:IPR038207|mint:O14641|rcsb pdb:2REY|rcsb pdb:3CBX|rcsb pdb:3CBY|rcsb pdb:3CBZ|rcsb pdb:3CC0|rcsb pdb:4WIP|rcsb pdb:5LNP|rcsb pdb:5SUY|rcsb pdb:5SUZ|rcsb pdb:6IW3|rcsb pdb:6JCK|reactome:R-HSA-201681|reactome:R-HSA-201688|reactome:R-HSA-2028269|reactome:R-HSA-4086400|reactome:R-HSA-4608870|reactome:R-HSA-4641258|reactome:R-HSA-4641262|reactome:R-HSA-5099900|reactome:R-HSA-5368598|reactome:R-HSA-5663220|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-9673324|ensembl:ENSP00000005340|dip:DIP-34433N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 4A, Supp. Fig. 7B|comment:The Dvl2 mutation prevents Smurf2 interacting with both Dvl2 and Par6|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2009/05/28	2014/10/16	rogid:a+mJTESi3rlZ5TMmGrZSxYo5FkM10090	rogid:2Vdc8oRnT4Mz/j+EXQXrL3AszOc9606	intact-crc:5B2F49AD9E568F64|rigid:GOUhR0RiGDkl9gZ4LszFV4Hs+uw	false	mutation:716-716|myc tag:?-?	flag tag:?-?|mutation decreasing interaction:499-499	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:A2A5Z6	uniprotkb:Q9Z101	intact:EBI-2348309|uniprotkb:A2A5Z7|uniprotkb:Q5IRE6|ensembl:ENSMUSP00000090177|ensembl:ENSMUSP00000129269	intact:EBI-81732|uniprotkb:Q5RL03|uniprotkb:Q6P8R2|ensembl:ENSMUSP00000090886	psi-mi:smuf2_mouse(display_long)|uniprotkb:Smurf2(gene name)|psi-mi:Smurf2(display_short)|uniprotkb:SMAD ubiquitination regulatory factor 2(gene name synonym)|uniprotkb:SMAD-specific E3 ubiquitin-protein ligase 2(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase SMURF2(gene name synonym)	psi-mi:par6a_mouse(display_long)|uniprotkb:Pard6a(gene name)|psi-mi:Pard6a(display_short)|uniprotkb:Par6a(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Narimatsu et al. (2009)	imex:IM-12177|pubmed:19379695	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2348536|imex:IM-12177-13	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079757.2|refseq:XP_006533999.1|ensembl:ENSMUSG00000018363(gene)|ensembl:ENSMUST00000092517(transcript)|ensembl:ENSMUST00000167787(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016607"(nuclear speck)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046332"(SMAD binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|reactome:R-MMU-201451|reactome:R-MMU-2173788|reactome:R-MMU-2173795|reactome:R-MMU-4608870|reactome:R-MMU-4641257|reactome:R-MMU-5632684|reactome:R-MMU-5689880|reactome:R-MMU-8941858|reactome:R-MMU-983168	refseq:NP_001040900.1|refseq:NP_062669.2|ensembl:ENSMUSG00000005699(gene)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0005938"(cell cortex)|ensembl:ENSMUST00000093195(transcript)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030054"(cell junction)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034451"(centriolar satellite)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045217"(cell-cell junction maintenance)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0051301"(cell division)|go:"GO:0060341"(regulation of cellular localization)|go:"GO:1904781"(positive regulation of protein localization to centrosome)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR034868|interpro:IPR034872|interpro:IPR036034|reactome:R-MMU-2173791|reactome:R-MMU-420029|reactome:R-MMU-4608870|reactome:R-MMU-9013148|reactome:R-MMU-9013149|dip:DIP-32553N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 4A, Supp. Fig. 7B|comment:The Dvl2 mutation prevents Smurf2 interacting with both Dvl2 and Par6|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2009/05/28	2014/10/16	rogid:a+mJTESi3rlZ5TMmGrZSxYo5FkM10090	rogid:gmmbxc9dNybdFr3Tf6e8lN5H/vQ10090	intact-crc:5B2F49AD9E568F64|rigid:GOUhR0RiGDkl9gZ4LszFV4Hs+uw	false	mutation:716-716|myc tag:?-?	ha tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O14641	uniprotkb:Q9Z101	intact:EBI-740850|ensembl:ENSP00000005340|uniprotkb:Q53XM0|uniprotkb:D3DTN3	intact:EBI-81732|uniprotkb:Q5RL03|uniprotkb:Q6P8R2|ensembl:ENSMUSP00000090886	psi-mi:dvl2_human(display_long)|uniprotkb:DSH homolog 2(gene name synonym)|uniprotkb:DVL2(gene name)|psi-mi:DVL2(display_short)	psi-mi:par6a_mouse(display_long)|uniprotkb:Pard6a(gene name)|psi-mi:Pard6a(display_short)|uniprotkb:Par6a(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Narimatsu et al. (2009)	imex:IM-12177|pubmed:19379695	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2348553|imex:IM-12177-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004413.1|ensembl:ENSG00000004975(gene)|ensembl:ENST00000005340(transcript)|go:"GO:0001843"(neural tube closure)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0005109"(frizzled binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007379"(segment specification)|go:"GO:0007507"(heart development)|go:"GO:0016235"(aggresome)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022007"(convergent extension involved in neural plate elongation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035567"(non-canonical Wnt signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0044340"(canonical Wnt signaling pathway involved in regulation of cell proliferation)|go:"GO:0045177"(apical part of cell)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0090179"(planar cell polarity pathway involved in neural tube closure)|go:"GO:0150012"(positive regulation of neuron projection arborization)|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|interpro:IPR001158(DIX)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR003351(Dishevelled protein)|interpro:IPR008339(Dishevelled region)|interpro:IPR008341(Dishevelled-2 region)|interpro:IPR015506(Dishevelled related protein)|interpro:IPR024580|interpro:IPR029071|interpro:IPR036034|interpro:IPR036388|interpro:IPR036390|interpro:IPR038207|mint:O14641|rcsb pdb:2REY|rcsb pdb:3CBX|rcsb pdb:3CBY|rcsb pdb:3CBZ|rcsb pdb:3CC0|rcsb pdb:4WIP|rcsb pdb:5LNP|rcsb pdb:5SUY|rcsb pdb:5SUZ|rcsb pdb:6IW3|rcsb pdb:6JCK|reactome:R-HSA-201681|reactome:R-HSA-201688|reactome:R-HSA-2028269|reactome:R-HSA-4086400|reactome:R-HSA-4608870|reactome:R-HSA-4641258|reactome:R-HSA-4641262|reactome:R-HSA-5099900|reactome:R-HSA-5368598|reactome:R-HSA-5663220|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-9673324|ensembl:ENSP00000005340|dip:DIP-34433N	refseq:NP_001040900.1|refseq:NP_062669.2|ensembl:ENSMUSG00000005699(gene)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0005938"(cell cortex)|ensembl:ENSMUST00000093195(transcript)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030054"(cell junction)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034451"(centriolar satellite)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045217"(cell-cell junction maintenance)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0051301"(cell division)|go:"GO:0060341"(regulation of cellular localization)|go:"GO:1904781"(positive regulation of protein localization to centrosome)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR034868|interpro:IPR034872|interpro:IPR036034|reactome:R-MMU-2173791|reactome:R-MMU-420029|reactome:R-MMU-4608870|reactome:R-MMU-9013148|reactome:R-MMU-9013149|dip:DIP-32553N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 4A, Supp. Fig. 7B|comment:The Dvl2 mutation prevents interaction with Smurf2 but not Par6|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2009/05/28	2014/10/16	rogid:2Vdc8oRnT4Mz/j+EXQXrL3AszOc9606	rogid:gmmbxc9dNybdFr3Tf6e8lN5H/vQ10090	intact-crc:567B89C9B4E0E12C|rigid:GOUhR0RiGDkl9gZ4LszFV4Hs+uw	false	flag tag:?-?|mutation decreasing interaction:499-499	ha tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O14641	uniprotkb:A2A5Z6	intact:EBI-740850|ensembl:ENSP00000005340|uniprotkb:Q53XM0|uniprotkb:D3DTN3	intact:EBI-2348309|uniprotkb:A2A5Z7|uniprotkb:Q5IRE6|ensembl:ENSMUSP00000090177|ensembl:ENSMUSP00000129269	psi-mi:dvl2_human(display_long)|uniprotkb:DSH homolog 2(gene name synonym)|uniprotkb:DVL2(gene name)|psi-mi:DVL2(display_short)	psi-mi:smuf2_mouse(display_long)|uniprotkb:Smurf2(gene name)|psi-mi:Smurf2(display_short)|uniprotkb:SMAD ubiquitination regulatory factor 2(gene name synonym)|uniprotkb:SMAD-specific E3 ubiquitin-protein ligase 2(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase SMURF2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Narimatsu et al. (2009)	imex:IM-12177|pubmed:19379695	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2348553|imex:IM-12177-2	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004413.1|ensembl:ENSG00000004975(gene)|ensembl:ENST00000005340(transcript)|go:"GO:0001843"(neural tube closure)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0005109"(frizzled binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007379"(segment specification)|go:"GO:0007507"(heart development)|go:"GO:0016235"(aggresome)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022007"(convergent extension involved in neural plate elongation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035567"(non-canonical Wnt signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0044340"(canonical Wnt signaling pathway involved in regulation of cell proliferation)|go:"GO:0045177"(apical part of cell)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0090179"(planar cell polarity pathway involved in neural tube closure)|go:"GO:0150012"(positive regulation of neuron projection arborization)|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|interpro:IPR001158(DIX)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR003351(Dishevelled protein)|interpro:IPR008339(Dishevelled region)|interpro:IPR008341(Dishevelled-2 region)|interpro:IPR015506(Dishevelled related protein)|interpro:IPR024580|interpro:IPR029071|interpro:IPR036034|interpro:IPR036388|interpro:IPR036390|interpro:IPR038207|mint:O14641|rcsb pdb:2REY|rcsb pdb:3CBX|rcsb pdb:3CBY|rcsb pdb:3CBZ|rcsb pdb:3CC0|rcsb pdb:4WIP|rcsb pdb:5LNP|rcsb pdb:5SUY|rcsb pdb:5SUZ|rcsb pdb:6IW3|rcsb pdb:6JCK|reactome:R-HSA-201681|reactome:R-HSA-201688|reactome:R-HSA-2028269|reactome:R-HSA-4086400|reactome:R-HSA-4608870|reactome:R-HSA-4641258|reactome:R-HSA-4641262|reactome:R-HSA-5099900|reactome:R-HSA-5368598|reactome:R-HSA-5663220|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-9673324|ensembl:ENSP00000005340|dip:DIP-34433N	refseq:NP_079757.2|refseq:XP_006533999.1|ensembl:ENSMUSG00000018363(gene)|ensembl:ENSMUST00000092517(transcript)|ensembl:ENSMUST00000167787(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016607"(nuclear speck)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046332"(SMAD binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|reactome:R-MMU-201451|reactome:R-MMU-2173788|reactome:R-MMU-2173795|reactome:R-MMU-4608870|reactome:R-MMU-4641257|reactome:R-MMU-5632684|reactome:R-MMU-5689880|reactome:R-MMU-8941858|reactome:R-MMU-983168	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 4A, Supp. Fig. 7B|comment:The Dvl2 mutation prevents interaction with Smurf2 but not Par6|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2009/05/28	2014/10/16	rogid:2Vdc8oRnT4Mz/j+EXQXrL3AszOc9606	rogid:a+mJTESi3rlZ5TMmGrZSxYo5FkM10090	intact-crc:567B89C9B4E0E12C|rigid:GOUhR0RiGDkl9gZ4LszFV4Hs+uw	false	flag tag:?-?|mutation decreasing interaction:499-499	mutation:716-716|myc tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O14641	uniprotkb:Q9Z101	intact:EBI-740850|ensembl:ENSP00000005340|uniprotkb:Q53XM0|uniprotkb:D3DTN3	intact:EBI-81732|uniprotkb:Q5RL03|uniprotkb:Q6P8R2|ensembl:ENSMUSP00000090886	psi-mi:dvl2_human(display_long)|uniprotkb:DSH homolog 2(gene name synonym)|uniprotkb:DVL2(gene name)|psi-mi:DVL2(display_short)	psi-mi:par6a_mouse(display_long)|uniprotkb:Pard6a(gene name)|psi-mi:Pard6a(display_short)|uniprotkb:Par6a(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Narimatsu et al. (2009)	imex:IM-12177|pubmed:19379695	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2348570|imex:IM-12177-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004413.1|ensembl:ENSG00000004975(gene)|ensembl:ENST00000005340(transcript)|go:"GO:0001843"(neural tube closure)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0005109"(frizzled binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007379"(segment specification)|go:"GO:0007507"(heart development)|go:"GO:0016235"(aggresome)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022007"(convergent extension involved in neural plate elongation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035567"(non-canonical Wnt signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0044340"(canonical Wnt signaling pathway involved in regulation of cell proliferation)|go:"GO:0045177"(apical part of cell)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0090179"(planar cell polarity pathway involved in neural tube closure)|go:"GO:0150012"(positive regulation of neuron projection arborization)|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|interpro:IPR001158(DIX)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR003351(Dishevelled protein)|interpro:IPR008339(Dishevelled region)|interpro:IPR008341(Dishevelled-2 region)|interpro:IPR015506(Dishevelled related protein)|interpro:IPR024580|interpro:IPR029071|interpro:IPR036034|interpro:IPR036388|interpro:IPR036390|interpro:IPR038207|mint:O14641|rcsb pdb:2REY|rcsb pdb:3CBX|rcsb pdb:3CBY|rcsb pdb:3CBZ|rcsb pdb:3CC0|rcsb pdb:4WIP|rcsb pdb:5LNP|rcsb pdb:5SUY|rcsb pdb:5SUZ|rcsb pdb:6IW3|rcsb pdb:6JCK|reactome:R-HSA-201681|reactome:R-HSA-201688|reactome:R-HSA-2028269|reactome:R-HSA-4086400|reactome:R-HSA-4608870|reactome:R-HSA-4641258|reactome:R-HSA-4641262|reactome:R-HSA-5099900|reactome:R-HSA-5368598|reactome:R-HSA-5663220|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-9673324|ensembl:ENSP00000005340|dip:DIP-34433N	refseq:NP_001040900.1|refseq:NP_062669.2|ensembl:ENSMUSG00000005699(gene)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0005938"(cell cortex)|ensembl:ENSMUST00000093195(transcript)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030054"(cell junction)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034451"(centriolar satellite)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045217"(cell-cell junction maintenance)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0051301"(cell division)|go:"GO:0060341"(regulation of cellular localization)|go:"GO:1904781"(positive regulation of protein localization to centrosome)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR034868|interpro:IPR034872|interpro:IPR036034|reactome:R-MMU-2173791|reactome:R-MMU-420029|reactome:R-MMU-4608870|reactome:R-MMU-9013148|reactome:R-MMU-9013149|dip:DIP-32553N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 4A|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2009/05/28	2014/10/16	rogid:2Vdc8oRnT4Mz/j+EXQXrL3AszOc9606	rogid:gmmbxc9dNybdFr3Tf6e8lN5H/vQ10090	intact-crc:70FE3AB152C9F245|rigid:gYfeDBQuuDBvl+CwKSz0nOEl7X0	false	flag tag:?-?	ha tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9Z101	uniprotkb:O14641	intact:EBI-81732|uniprotkb:Q5RL03|uniprotkb:Q6P8R2|ensembl:ENSMUSP00000090886	intact:EBI-740850|ensembl:ENSP00000005340|uniprotkb:Q53XM0|uniprotkb:D3DTN3	psi-mi:par6a_mouse(display_long)|uniprotkb:Pard6a(gene name)|psi-mi:Pard6a(display_short)|uniprotkb:Par6a(gene name synonym)	psi-mi:dvl2_human(display_long)|uniprotkb:DSH homolog 2(gene name synonym)|uniprotkb:DVL2(gene name)|psi-mi:DVL2(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Narimatsu et al. (2009)	imex:IM-12177|pubmed:19379695	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2348623|imex:IM-12177-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001040900.1|refseq:NP_062669.2|ensembl:ENSMUSG00000005699(gene)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0005938"(cell cortex)|ensembl:ENSMUST00000093195(transcript)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030054"(cell junction)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034451"(centriolar satellite)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045217"(cell-cell junction maintenance)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0051301"(cell division)|go:"GO:0060341"(regulation of cellular localization)|go:"GO:1904781"(positive regulation of protein localization to centrosome)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR034868|interpro:IPR034872|interpro:IPR036034|reactome:R-MMU-2173791|reactome:R-MMU-420029|reactome:R-MMU-4608870|reactome:R-MMU-9013148|reactome:R-MMU-9013149|dip:DIP-32553N	refseq:NP_004413.1|ensembl:ENSG00000004975(gene)|ensembl:ENST00000005340(transcript)|go:"GO:0001843"(neural tube closure)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0005109"(frizzled binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007379"(segment specification)|go:"GO:0007507"(heart development)|go:"GO:0016235"(aggresome)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022007"(convergent extension involved in neural plate elongation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035567"(non-canonical Wnt signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0044340"(canonical Wnt signaling pathway involved in regulation of cell proliferation)|go:"GO:0045177"(apical part of cell)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0090179"(planar cell polarity pathway involved in neural tube closure)|go:"GO:0150012"(positive regulation of neuron projection arborization)|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|interpro:IPR001158(DIX)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR003351(Dishevelled protein)|interpro:IPR008339(Dishevelled region)|interpro:IPR008341(Dishevelled-2 region)|interpro:IPR015506(Dishevelled related protein)|interpro:IPR024580|interpro:IPR029071|interpro:IPR036034|interpro:IPR036388|interpro:IPR036390|interpro:IPR038207|mint:O14641|rcsb pdb:2REY|rcsb pdb:3CBX|rcsb pdb:3CBY|rcsb pdb:3CBZ|rcsb pdb:3CC0|rcsb pdb:4WIP|rcsb pdb:5LNP|rcsb pdb:5SUY|rcsb pdb:5SUZ|rcsb pdb:6IW3|rcsb pdb:6JCK|reactome:R-HSA-201681|reactome:R-HSA-201688|reactome:R-HSA-2028269|reactome:R-HSA-4086400|reactome:R-HSA-4608870|reactome:R-HSA-4641258|reactome:R-HSA-4641262|reactome:R-HSA-5099900|reactome:R-HSA-5368598|reactome:R-HSA-5663220|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-9673324|ensembl:ENSP00000005340|dip:DIP-34433N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 4D|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2009/05/28	2014/10/16	rogid:gmmbxc9dNybdFr3Tf6e8lN5H/vQ10090	rogid:2Vdc8oRnT4Mz/j+EXQXrL3AszOc9606	intact-crc:45129969C15D14DF|rigid:gYfeDBQuuDBvl+CwKSz0nOEl7X0	false	flag tag:?-?|necessary binding region:251-290	t7 tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9Z101	uniprotkb:O14641	intact:EBI-81732|uniprotkb:Q5RL03|uniprotkb:Q6P8R2|ensembl:ENSMUSP00000090886	intact:EBI-740850|ensembl:ENSP00000005340|uniprotkb:Q53XM0|uniprotkb:D3DTN3	psi-mi:par6a_mouse(display_long)|uniprotkb:Pard6a(gene name)|psi-mi:Pard6a(display_short)|uniprotkb:Par6a(gene name synonym)	psi-mi:dvl2_human(display_long)|uniprotkb:DSH homolog 2(gene name synonym)|uniprotkb:DVL2(gene name)|psi-mi:DVL2(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Narimatsu et al. (2009)	imex:IM-12177|pubmed:19379695	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2348639|imex:IM-12177-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001040900.1|refseq:NP_062669.2|ensembl:ENSMUSG00000005699(gene)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0005938"(cell cortex)|ensembl:ENSMUST00000093195(transcript)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030054"(cell junction)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034451"(centriolar satellite)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045217"(cell-cell junction maintenance)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0051301"(cell division)|go:"GO:0060341"(regulation of cellular localization)|go:"GO:1904781"(positive regulation of protein localization to centrosome)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR034868|interpro:IPR034872|interpro:IPR036034|reactome:R-MMU-2173791|reactome:R-MMU-420029|reactome:R-MMU-4608870|reactome:R-MMU-9013148|reactome:R-MMU-9013149|dip:DIP-32553N	refseq:NP_004413.1|ensembl:ENSG00000004975(gene)|ensembl:ENST00000005340(transcript)|go:"GO:0001843"(neural tube closure)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0005109"(frizzled binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007379"(segment specification)|go:"GO:0007507"(heart development)|go:"GO:0016235"(aggresome)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022007"(convergent extension involved in neural plate elongation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035567"(non-canonical Wnt signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0044340"(canonical Wnt signaling pathway involved in regulation of cell proliferation)|go:"GO:0045177"(apical part of cell)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0090179"(planar cell polarity pathway involved in neural tube closure)|go:"GO:0150012"(positive regulation of neuron projection arborization)|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|interpro:IPR001158(DIX)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR003351(Dishevelled protein)|interpro:IPR008339(Dishevelled region)|interpro:IPR008341(Dishevelled-2 region)|interpro:IPR015506(Dishevelled related protein)|interpro:IPR024580|interpro:IPR029071|interpro:IPR036034|interpro:IPR036388|interpro:IPR036390|interpro:IPR038207|mint:O14641|rcsb pdb:2REY|rcsb pdb:3CBX|rcsb pdb:3CBY|rcsb pdb:3CBZ|rcsb pdb:3CC0|rcsb pdb:4WIP|rcsb pdb:5LNP|rcsb pdb:5SUY|rcsb pdb:5SUZ|rcsb pdb:6IW3|rcsb pdb:6JCK|reactome:R-HSA-201681|reactome:R-HSA-201688|reactome:R-HSA-2028269|reactome:R-HSA-4086400|reactome:R-HSA-4608870|reactome:R-HSA-4641258|reactome:R-HSA-4641262|reactome:R-HSA-5099900|reactome:R-HSA-5368598|reactome:R-HSA-5663220|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-9673324|ensembl:ENSP00000005340|dip:DIP-34433N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 4E|comment:Deletion of residues 251-290 of Pard6a prevents binding to both DVL2 and Smurf2.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2009/05/28	2014/10/16	rogid:gmmbxc9dNybdFr3Tf6e8lN5H/vQ10090	rogid:2Vdc8oRnT4Mz/j+EXQXrL3AszOc9606	intact-crc:D8BA31609C0CB6F1|rigid:GOUhR0RiGDkl9gZ4LszFV4Hs+uw	false	flag tag:?-?|necessary binding region:251-290	t7 tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9Z101	uniprotkb:A2A5Z6	intact:EBI-81732|uniprotkb:Q5RL03|uniprotkb:Q6P8R2|ensembl:ENSMUSP00000090886	intact:EBI-2348309|uniprotkb:A2A5Z7|uniprotkb:Q5IRE6|ensembl:ENSMUSP00000090177|ensembl:ENSMUSP00000129269	psi-mi:par6a_mouse(display_long)|uniprotkb:Pard6a(gene name)|psi-mi:Pard6a(display_short)|uniprotkb:Par6a(gene name synonym)	psi-mi:smuf2_mouse(display_long)|uniprotkb:Smurf2(gene name)|psi-mi:Smurf2(display_short)|uniprotkb:SMAD ubiquitination regulatory factor 2(gene name synonym)|uniprotkb:SMAD-specific E3 ubiquitin-protein ligase 2(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase SMURF2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Narimatsu et al. (2009)	imex:IM-12177|pubmed:19379695	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2348639|imex:IM-12177-11	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001040900.1|refseq:NP_062669.2|ensembl:ENSMUSG00000005699(gene)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0005938"(cell cortex)|ensembl:ENSMUST00000093195(transcript)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030054"(cell junction)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034451"(centriolar satellite)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045217"(cell-cell junction maintenance)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0051301"(cell division)|go:"GO:0060341"(regulation of cellular localization)|go:"GO:1904781"(positive regulation of protein localization to centrosome)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR034868|interpro:IPR034872|interpro:IPR036034|reactome:R-MMU-2173791|reactome:R-MMU-420029|reactome:R-MMU-4608870|reactome:R-MMU-9013148|reactome:R-MMU-9013149|dip:DIP-32553N	refseq:NP_079757.2|refseq:XP_006533999.1|ensembl:ENSMUSG00000018363(gene)|ensembl:ENSMUST00000092517(transcript)|ensembl:ENSMUST00000167787(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016607"(nuclear speck)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046332"(SMAD binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|reactome:R-MMU-201451|reactome:R-MMU-2173788|reactome:R-MMU-2173795|reactome:R-MMU-4608870|reactome:R-MMU-4641257|reactome:R-MMU-5632684|reactome:R-MMU-5689880|reactome:R-MMU-8941858|reactome:R-MMU-983168	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 4E|comment:Deletion of residues 251-290 of Pard6a prevents binding to both DVL2 and Smurf2.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2009/05/28	2014/10/16	rogid:gmmbxc9dNybdFr3Tf6e8lN5H/vQ10090	rogid:a+mJTESi3rlZ5TMmGrZSxYo5FkM10090	intact-crc:D8BA31609C0CB6F1|rigid:GOUhR0RiGDkl9gZ4LszFV4Hs+uw	false	flag tag:?-?|necessary binding region:251-290	ha tag:?-?|mutation:716-716	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:A2A5Z6	uniprotkb:Q96MT3	intact:EBI-2348309|uniprotkb:A2A5Z7|uniprotkb:Q5IRE6|ensembl:ENSMUSP00000090177|ensembl:ENSMUSP00000129269	intact:EBI-2348662|uniprotkb:Q14C83|uniprotkb:Q71QF8|uniprotkb:Q96N00|ensembl:ENSP00000345064|ensembl:ENSP00000398947|ensembl:ENSP00000401060|ensembl:ENSP00000448359|ensembl:ENSP00000449819|ensembl:ENSP00000491051|ensembl:ENSP00000491228|ensembl:ENSP00000492332|ensembl:ENSP00000492644|ensembl:ENSP00000492763	psi-mi:smuf2_mouse(display_long)|uniprotkb:Smurf2(gene name)|psi-mi:Smurf2(display_short)|uniprotkb:SMAD ubiquitination regulatory factor 2(gene name synonym)|uniprotkb:SMAD-specific E3 ubiquitin-protein ligase 2(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase SMURF2(gene name synonym)	psi-mi:pric1_human(display_long)|uniprotkb:PRICKLE1(gene name)|psi-mi:PRICKLE1(display_short)|uniprotkb:RILP(gene name synonym)|uniprotkb:REST/NRSF-interacting LIM domain protein 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Narimatsu et al. (2009)	imex:IM-12177|pubmed:19379695	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2348682|imex:IM-12177-14	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079757.2|refseq:XP_006533999.1|ensembl:ENSMUSG00000018363(gene)|ensembl:ENSMUST00000092517(transcript)|ensembl:ENSMUST00000167787(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016607"(nuclear speck)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046332"(SMAD binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|reactome:R-MMU-201451|reactome:R-MMU-2173788|reactome:R-MMU-2173795|reactome:R-MMU-4608870|reactome:R-MMU-4641257|reactome:R-MMU-5632684|reactome:R-MMU-5689880|reactome:R-MMU-8941858|reactome:R-MMU-983168	refseq:XP_011536248.1|refseq:XP_011536249.1|refseq:NP_001138353.1|refseq:NP_001138354.1|refseq:NP_001138355.1|refseq:NP_694571.2|refseq:XP_016874327.1|refseq:XP_016874328.1|refseq:XP_016874329.1|ensembl:ENSG00000139174(gene)|ensembl:ENST00000345127(transcript)|ensembl:ENST00000445766(transcript)|ensembl:ENST00000455697(transcript)|ensembl:ENST00000548696(transcript)|ensembl:ENST00000552240(transcript)|ensembl:ENST00000639566(transcript)|ensembl:ENST00000639589(transcript)|ensembl:ENST00000639958(transcript)|ensembl:ENST00000640055(transcript)|ensembl:ENST00000640132(transcript)|go:"GO:0001843"(neural tube closure)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0008270"(zinc ion binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0035904"(aorta development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0060976"(coronary vasculature development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:2000691"(negative regulation of cardiac muscle cell myoblast differentiation)|interpro:IPR001781(Zinc finger, LIM-type)|interpro:IPR010442(PET)|interpro:IPR033723|interpro:IPR033726|interpro:IPR033727|reactome:R-HSA-4608870	psi-mi:"MI:0469"(intact)	-	-	figure legend:Figs. 5A|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2009/05/28	2014/10/16	rogid:a+mJTESi3rlZ5TMmGrZSxYo5FkM10090	rogid:Ja2xuOriMFG/HYyzg7JuPnFlaOM9606	intact-crc:E72E4F7BDBC9E00B|rigid:6DpG+6m9Pt5oWUODB214yKlYD4o	false	mutation:716-716|myc tag:?-?	flag tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q96MT3	uniprotkb:O14641	intact:EBI-2348662|uniprotkb:Q14C83|uniprotkb:Q71QF8|uniprotkb:Q96N00|ensembl:ENSP00000345064|ensembl:ENSP00000398947|ensembl:ENSP00000401060|ensembl:ENSP00000448359|ensembl:ENSP00000449819|ensembl:ENSP00000491051|ensembl:ENSP00000491228|ensembl:ENSP00000492332|ensembl:ENSP00000492644|ensembl:ENSP00000492763	intact:EBI-740850|ensembl:ENSP00000005340|uniprotkb:Q53XM0|uniprotkb:D3DTN3	psi-mi:pric1_human(display_long)|uniprotkb:PRICKLE1(gene name)|psi-mi:PRICKLE1(display_short)|uniprotkb:RILP(gene name synonym)|uniprotkb:REST/NRSF-interacting LIM domain protein 1(gene name synonym)	psi-mi:dvl2_human(display_long)|uniprotkb:DSH homolog 2(gene name synonym)|uniprotkb:DVL2(gene name)|psi-mi:DVL2(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Narimatsu et al. (2009)	imex:IM-12177|pubmed:19379695	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2348709|imex:IM-12177-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011536248.1|refseq:XP_011536249.1|refseq:NP_001138353.1|refseq:NP_001138354.1|refseq:NP_001138355.1|refseq:NP_694571.2|refseq:XP_016874327.1|refseq:XP_016874328.1|refseq:XP_016874329.1|ensembl:ENSG00000139174(gene)|ensembl:ENST00000345127(transcript)|ensembl:ENST00000445766(transcript)|ensembl:ENST00000455697(transcript)|ensembl:ENST00000548696(transcript)|ensembl:ENST00000552240(transcript)|ensembl:ENST00000639566(transcript)|ensembl:ENST00000639589(transcript)|ensembl:ENST00000639958(transcript)|ensembl:ENST00000640055(transcript)|ensembl:ENST00000640132(transcript)|go:"GO:0001843"(neural tube closure)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0008270"(zinc ion binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0035904"(aorta development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0060976"(coronary vasculature development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:2000691"(negative regulation of cardiac muscle cell myoblast differentiation)|interpro:IPR001781(Zinc finger, LIM-type)|interpro:IPR010442(PET)|interpro:IPR033723|interpro:IPR033726|interpro:IPR033727|reactome:R-HSA-4608870	refseq:NP_004413.1|ensembl:ENSG00000004975(gene)|ensembl:ENST00000005340(transcript)|go:"GO:0001843"(neural tube closure)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0005109"(frizzled binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007379"(segment specification)|go:"GO:0007507"(heart development)|go:"GO:0016235"(aggresome)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022007"(convergent extension involved in neural plate elongation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035567"(non-canonical Wnt signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0044340"(canonical Wnt signaling pathway involved in regulation of cell proliferation)|go:"GO:0045177"(apical part of cell)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0090179"(planar cell polarity pathway involved in neural tube closure)|go:"GO:0150012"(positive regulation of neuron projection arborization)|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|interpro:IPR001158(DIX)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR003351(Dishevelled protein)|interpro:IPR008339(Dishevelled region)|interpro:IPR008341(Dishevelled-2 region)|interpro:IPR015506(Dishevelled related protein)|interpro:IPR024580|interpro:IPR029071|interpro:IPR036034|interpro:IPR036388|interpro:IPR036390|interpro:IPR038207|mint:O14641|rcsb pdb:2REY|rcsb pdb:3CBX|rcsb pdb:3CBY|rcsb pdb:3CBZ|rcsb pdb:3CC0|rcsb pdb:4WIP|rcsb pdb:5LNP|rcsb pdb:5SUY|rcsb pdb:5SUZ|rcsb pdb:6IW3|rcsb pdb:6JCK|reactome:R-HSA-201681|reactome:R-HSA-201688|reactome:R-HSA-2028269|reactome:R-HSA-4086400|reactome:R-HSA-4608870|reactome:R-HSA-4641258|reactome:R-HSA-4641262|reactome:R-HSA-5099900|reactome:R-HSA-5368598|reactome:R-HSA-5663220|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-9673324|ensembl:ENSP00000005340|dip:DIP-34433N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 5B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2009/05/28	2014/10/16	rogid:Ja2xuOriMFG/HYyzg7JuPnFlaOM9606	rogid:2Vdc8oRnT4Mz/j+EXQXrL3AszOc9606	intact-crc:956CEF68F6E9AD83|rigid:kepIua1dOkPNlC8Xz5t5ZKFlLpM	false	green fluorescent protein tag:?-?	flag tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q96MT3	uniprotkb:Q9Z101	intact:EBI-2348662|uniprotkb:Q14C83|uniprotkb:Q71QF8|uniprotkb:Q96N00|ensembl:ENSP00000345064|ensembl:ENSP00000398947|ensembl:ENSP00000401060|ensembl:ENSP00000448359|ensembl:ENSP00000449819|ensembl:ENSP00000491051|ensembl:ENSP00000491228|ensembl:ENSP00000492332|ensembl:ENSP00000492644|ensembl:ENSP00000492763	intact:EBI-81732|uniprotkb:Q5RL03|uniprotkb:Q6P8R2|ensembl:ENSMUSP00000090886	psi-mi:pric1_human(display_long)|uniprotkb:PRICKLE1(gene name)|psi-mi:PRICKLE1(display_short)|uniprotkb:RILP(gene name synonym)|uniprotkb:REST/NRSF-interacting LIM domain protein 1(gene name synonym)	psi-mi:par6a_mouse(display_long)|uniprotkb:Pard6a(gene name)|psi-mi:Pard6a(display_short)|uniprotkb:Par6a(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Narimatsu et al. (2009)	imex:IM-12177|pubmed:19379695	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2348721|imex:IM-12177-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011536248.1|refseq:XP_011536249.1|refseq:NP_001138353.1|refseq:NP_001138354.1|refseq:NP_001138355.1|refseq:NP_694571.2|refseq:XP_016874327.1|refseq:XP_016874328.1|refseq:XP_016874329.1|ensembl:ENSG00000139174(gene)|ensembl:ENST00000345127(transcript)|ensembl:ENST00000445766(transcript)|ensembl:ENST00000455697(transcript)|ensembl:ENST00000548696(transcript)|ensembl:ENST00000552240(transcript)|ensembl:ENST00000639566(transcript)|ensembl:ENST00000639589(transcript)|ensembl:ENST00000639958(transcript)|ensembl:ENST00000640055(transcript)|ensembl:ENST00000640132(transcript)|go:"GO:0001843"(neural tube closure)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0008270"(zinc ion binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0035904"(aorta development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0060976"(coronary vasculature development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:2000691"(negative regulation of cardiac muscle cell myoblast differentiation)|interpro:IPR001781(Zinc finger, LIM-type)|interpro:IPR010442(PET)|interpro:IPR033723|interpro:IPR033726|interpro:IPR033727|reactome:R-HSA-4608870	refseq:NP_001040900.1|refseq:NP_062669.2|ensembl:ENSMUSG00000005699(gene)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0005938"(cell cortex)|ensembl:ENSMUST00000093195(transcript)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030054"(cell junction)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034451"(centriolar satellite)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045217"(cell-cell junction maintenance)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0051301"(cell division)|go:"GO:0060341"(regulation of cellular localization)|go:"GO:1904781"(positive regulation of protein localization to centrosome)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR034868|interpro:IPR034872|interpro:IPR036034|reactome:R-MMU-2173791|reactome:R-MMU-420029|reactome:R-MMU-4608870|reactome:R-MMU-9013148|reactome:R-MMU-9013149|dip:DIP-32553N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 5B, 5C|comment:Levels of PRICKLE1 bound to Par6 were decreased in the presence of wild-type Smurf2, but not the catalytic mutant. Treatment with the proteasome inhibitor, LLnL also blocked Smurf2-mediated reduction in PRICKLE1 protein.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2009/05/28	2014/10/16	rogid:Ja2xuOriMFG/HYyzg7JuPnFlaOM9606	rogid:gmmbxc9dNybdFr3Tf6e8lN5H/vQ10090	intact-crc:3A13B81706140680|rigid:Oe+cOPDaijn0gLUmairqzL6SSx0	false	green fluorescent protein tag:?-?	flag tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O14641	uniprotkb:A2A5Z6	intact:EBI-740850|ensembl:ENSP00000005340|uniprotkb:Q53XM0|uniprotkb:D3DTN3	intact:EBI-2348309|uniprotkb:A2A5Z7|uniprotkb:Q5IRE6|ensembl:ENSMUSP00000090177|ensembl:ENSMUSP00000129269	psi-mi:dvl2_human(display_long)|uniprotkb:DSH homolog 2(gene name synonym)|uniprotkb:DVL2(gene name)|psi-mi:DVL2(display_short)	psi-mi:smuf2_mouse(display_long)|uniprotkb:Smurf2(gene name)|psi-mi:Smurf2(display_short)|uniprotkb:SMAD ubiquitination regulatory factor 2(gene name synonym)|uniprotkb:SMAD-specific E3 ubiquitin-protein ligase 2(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase SMURF2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Narimatsu et al. (2009)	imex:IM-12177|pubmed:19379695	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2348944|imex:IM-12177-12	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004413.1|ensembl:ENSG00000004975(gene)|ensembl:ENST00000005340(transcript)|go:"GO:0001843"(neural tube closure)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0005109"(frizzled binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007379"(segment specification)|go:"GO:0007507"(heart development)|go:"GO:0016235"(aggresome)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022007"(convergent extension involved in neural plate elongation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035567"(non-canonical Wnt signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0044340"(canonical Wnt signaling pathway involved in regulation of cell proliferation)|go:"GO:0045177"(apical part of cell)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0090179"(planar cell polarity pathway involved in neural tube closure)|go:"GO:0150012"(positive regulation of neuron projection arborization)|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|interpro:IPR001158(DIX)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR003351(Dishevelled protein)|interpro:IPR008339(Dishevelled region)|interpro:IPR008341(Dishevelled-2 region)|interpro:IPR015506(Dishevelled related protein)|interpro:IPR024580|interpro:IPR029071|interpro:IPR036034|interpro:IPR036388|interpro:IPR036390|interpro:IPR038207|mint:O14641|rcsb pdb:2REY|rcsb pdb:3CBX|rcsb pdb:3CBY|rcsb pdb:3CBZ|rcsb pdb:3CC0|rcsb pdb:4WIP|rcsb pdb:5LNP|rcsb pdb:5SUY|rcsb pdb:5SUZ|rcsb pdb:6IW3|rcsb pdb:6JCK|reactome:R-HSA-201681|reactome:R-HSA-201688|reactome:R-HSA-2028269|reactome:R-HSA-4086400|reactome:R-HSA-4608870|reactome:R-HSA-4641258|reactome:R-HSA-4641262|reactome:R-HSA-5099900|reactome:R-HSA-5368598|reactome:R-HSA-5663220|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-9673324|ensembl:ENSP00000005340|dip:DIP-34433N	refseq:NP_079757.2|refseq:XP_006533999.1|ensembl:ENSMUSG00000018363(gene)|ensembl:ENSMUST00000092517(transcript)|ensembl:ENSMUST00000167787(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016607"(nuclear speck)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046332"(SMAD binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|reactome:R-MMU-201451|reactome:R-MMU-2173788|reactome:R-MMU-2173795|reactome:R-MMU-4608870|reactome:R-MMU-4641257|reactome:R-MMU-5632684|reactome:R-MMU-5689880|reactome:R-MMU-8941858|reactome:R-MMU-983168	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supp. Fig. 5B|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2009/05/28	2014/10/16	rogid:2Vdc8oRnT4Mz/j+EXQXrL3AszOc9606	rogid:a+mJTESi3rlZ5TMmGrZSxYo5FkM10090	intact-crc:54B1AC1FAFBBFD0D|rigid:boP5WYQt/JVGQ11VY95WPG7taM4	false	flag tag:?-?|necessary binding region:565-568	mutation:716-716|myc tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O14641	uniprotkb:Q9HCE7	intact:EBI-740850|ensembl:ENSP00000005340|uniprotkb:Q53XM0|uniprotkb:D3DTN3	intact:EBI-976466|uniprotkb:O75853|uniprotkb:Q9UJT8|ensembl:ENSP00000354621|ensembl:ENSP00000492201|uniprotkb:B7ZMB6|uniprotkb:B9EGV3|uniprotkb:Q547Q3|uniprotkb:A4D279	psi-mi:dvl2_human(display_long)|uniprotkb:DSH homolog 2(gene name synonym)|uniprotkb:DVL2(gene name)|psi-mi:DVL2(display_short)	psi-mi:smuf1_human(display_long)|uniprotkb:SMAD ubiquitination regulatory factor 1(gene name synonym)|uniprotkb:SMAD-specific E3 ubiquitin-protein ligase 1(gene name synonym)|uniprotkb:SMURF1(gene name)|psi-mi:SMURF1(display_short)|uniprotkb:KIAA1625(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase SMURF1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Narimatsu et al. (2009)	imex:IM-12177|pubmed:19379695	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2348958|imex:IM-12177-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004413.1|ensembl:ENSG00000004975(gene)|ensembl:ENST00000005340(transcript)|go:"GO:0001843"(neural tube closure)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0005109"(frizzled binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007379"(segment specification)|go:"GO:0007507"(heart development)|go:"GO:0016235"(aggresome)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022007"(convergent extension involved in neural plate elongation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035567"(non-canonical Wnt signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0044340"(canonical Wnt signaling pathway involved in regulation of cell proliferation)|go:"GO:0045177"(apical part of cell)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0090179"(planar cell polarity pathway involved in neural tube closure)|go:"GO:0150012"(positive regulation of neuron projection arborization)|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|interpro:IPR001158(DIX)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR003351(Dishevelled protein)|interpro:IPR008339(Dishevelled region)|interpro:IPR008341(Dishevelled-2 region)|interpro:IPR015506(Dishevelled related protein)|interpro:IPR024580|interpro:IPR029071|interpro:IPR036034|interpro:IPR036388|interpro:IPR036390|interpro:IPR038207|mint:O14641|rcsb pdb:2REY|rcsb pdb:3CBX|rcsb pdb:3CBY|rcsb pdb:3CBZ|rcsb pdb:3CC0|rcsb pdb:4WIP|rcsb pdb:5LNP|rcsb pdb:5SUY|rcsb pdb:5SUZ|rcsb pdb:6IW3|rcsb pdb:6JCK|reactome:R-HSA-201681|reactome:R-HSA-201688|reactome:R-HSA-2028269|reactome:R-HSA-4086400|reactome:R-HSA-4608870|reactome:R-HSA-4641258|reactome:R-HSA-4641262|reactome:R-HSA-5099900|reactome:R-HSA-5368598|reactome:R-HSA-5663220|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-9673324|ensembl:ENSP00000005340|dip:DIP-34433N	ensembl:ENSG00000198742(gene)|ensembl:ENSG00000284126(gene)|ensembl:ENST00000361125(transcript)|ensembl:ENST00000638647(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0007398"(ectoderm development)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030154"(cell differentiation)|go:"GO:0030424"(axon)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0048185"(activin binding)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061736"(engulfment of target by autophagosome)|go:"GO:0061753"(substrate localization to autophagosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0071211"(protein targeting to vacuole involved in autophagy)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:1903861"(positive regulation of dendrite extension)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|mint:Q9HCE7|rcsb pdb:2LB0|rcsb pdb:2LB1|rcsb pdb:2LTX|rcsb pdb:3PYC|reactome:R-HSA-201451|reactome:R-HSA-2173788|reactome:R-HSA-2173791|reactome:R-HSA-4608870|reactome:R-HSA-5632684|reactome:R-HSA-8939902|reactome:R-HSA-8941858|reactome:R-HSA-983168|rcsb pdb:2LAZ|refseq:NP_065162.1|refseq:NP_851994.1|refseq:NP_001186776.1|dip:DIP-36709N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supp. Fig. 5A|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2009/05/28	2014/10/16	rogid:2Vdc8oRnT4Mz/j+EXQXrL3AszOc9606	rogid:WFypGZd4qJom//+gDWfxmzjDG6M9606	intact-crc:46F7855CC2C656B2|rigid:guu2uuiL+67vjarUeT0YUjQiU7M	false	flag tag:?-?	myc tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O14641	uniprotkb:A2A5Z6	intact:EBI-740850|ensembl:ENSP00000005340|uniprotkb:Q53XM0|uniprotkb:D3DTN3	intact:EBI-2348309|uniprotkb:A2A5Z7|uniprotkb:Q5IRE6|ensembl:ENSMUSP00000090177|ensembl:ENSMUSP00000129269	psi-mi:dvl2_human(display_long)|uniprotkb:DSH homolog 2(gene name synonym)|uniprotkb:DVL2(gene name)|psi-mi:DVL2(display_short)	psi-mi:smuf2_mouse(display_long)|uniprotkb:Smurf2(gene name)|psi-mi:Smurf2(display_short)|uniprotkb:SMAD ubiquitination regulatory factor 2(gene name synonym)|uniprotkb:SMAD-specific E3 ubiquitin-protein ligase 2(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase SMURF2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Narimatsu et al. (2009)	imex:IM-12177|pubmed:19379695	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2348967|imex:IM-12177-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004413.1|ensembl:ENSG00000004975(gene)|ensembl:ENST00000005340(transcript)|go:"GO:0001843"(neural tube closure)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0005109"(frizzled binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007379"(segment specification)|go:"GO:0007507"(heart development)|go:"GO:0016235"(aggresome)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022007"(convergent extension involved in neural plate elongation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035567"(non-canonical Wnt signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0044340"(canonical Wnt signaling pathway involved in regulation of cell proliferation)|go:"GO:0045177"(apical part of cell)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0090179"(planar cell polarity pathway involved in neural tube closure)|go:"GO:0150012"(positive regulation of neuron projection arborization)|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|interpro:IPR001158(DIX)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR003351(Dishevelled protein)|interpro:IPR008339(Dishevelled region)|interpro:IPR008341(Dishevelled-2 region)|interpro:IPR015506(Dishevelled related protein)|interpro:IPR024580|interpro:IPR029071|interpro:IPR036034|interpro:IPR036388|interpro:IPR036390|interpro:IPR038207|mint:O14641|rcsb pdb:2REY|rcsb pdb:3CBX|rcsb pdb:3CBY|rcsb pdb:3CBZ|rcsb pdb:3CC0|rcsb pdb:4WIP|rcsb pdb:5LNP|rcsb pdb:5SUY|rcsb pdb:5SUZ|rcsb pdb:6IW3|rcsb pdb:6JCK|reactome:R-HSA-201681|reactome:R-HSA-201688|reactome:R-HSA-2028269|reactome:R-HSA-4086400|reactome:R-HSA-4608870|reactome:R-HSA-4641258|reactome:R-HSA-4641262|reactome:R-HSA-5099900|reactome:R-HSA-5368598|reactome:R-HSA-5663220|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-9673324|ensembl:ENSP00000005340|dip:DIP-34433N	refseq:NP_079757.2|refseq:XP_006533999.1|ensembl:ENSMUSG00000018363(gene)|ensembl:ENSMUST00000092517(transcript)|ensembl:ENSMUST00000167787(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016607"(nuclear speck)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046332"(SMAD binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|reactome:R-MMU-201451|reactome:R-MMU-2173788|reactome:R-MMU-2173795|reactome:R-MMU-4608870|reactome:R-MMU-4641257|reactome:R-MMU-5632684|reactome:R-MMU-5689880|reactome:R-MMU-8941858|reactome:R-MMU-983168	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supp. Fig. 5C|caution:Exact coordinates of WW2 domain not given in the text so have been inferred from the UniProt KB entry.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2009/05/28	2014/10/16	rogid:2Vdc8oRnT4Mz/j+EXQXrL3AszOc9606	rogid:a+mJTESi3rlZ5TMmGrZSxYo5FkM10090	intact-crc:2CE5F15C297C36A0|rigid:boP5WYQt/JVGQ11VY95WPG7taM4	false	t7 tag:?-?	mutation:716-716|flag tag:?-?|necessary binding region:251..251-284..284(IPR001202)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:A2A5Z6	uniprotkb:Q7Z3G6	intact:EBI-2348309|uniprotkb:A2A5Z7|uniprotkb:Q5IRE6|ensembl:ENSMUSP00000090177|ensembl:ENSMUSP00000129269	intact:EBI-2349026|uniprotkb:Q0VF44|ensembl:ENSP00000455004|ensembl:ENSP00000492363	psi-mi:smuf2_mouse(display_long)|uniprotkb:Smurf2(gene name)|psi-mi:Smurf2(display_short)|uniprotkb:SMAD ubiquitination regulatory factor 2(gene name synonym)|uniprotkb:SMAD-specific E3 ubiquitin-protein ligase 2(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase SMURF2(gene name synonym)	psi-mi:pric2_human(display_long)|uniprotkb:PRICKLE2(gene name)|psi-mi:PRICKLE2(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Narimatsu et al. (2009)	imex:IM-12177|pubmed:19379695	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2349039|imex:IM-12177-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079757.2|refseq:XP_006533999.1|ensembl:ENSMUSG00000018363(gene)|ensembl:ENSMUST00000092517(transcript)|ensembl:ENSMUST00000167787(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016607"(nuclear speck)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046332"(SMAD binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|reactome:R-MMU-201451|reactome:R-MMU-2173788|reactome:R-MMU-2173795|reactome:R-MMU-4608870|reactome:R-MMU-4641257|reactome:R-MMU-5632684|reactome:R-MMU-5689880|reactome:R-MMU-8941858|reactome:R-MMU-983168	refseq:NP_942559.1|refseq:XP_016861287.1|ensembl:ENSG00000163637(gene)|ensembl:ENST00000564377(transcript)|ensembl:ENST00000638394(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0008270"(zinc ion binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|interpro:IPR001781(Zinc finger, LIM-type)|interpro:IPR010442(PET)|interpro:IPR033723|interpro:IPR033725|interpro:IPR033726|interpro:IPR033727	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supp. Fig. 7D|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2009/05/28	2014/10/16	rogid:a+mJTESi3rlZ5TMmGrZSxYo5FkM10090	rogid:WctEbf5UCkMb2Lz9UZvwWfUPsBM9606	intact-crc:CB716D91409323C5|rigid:V728RSxwcZY0BSHV14GGZRgWmpc	false	myc tag:?-?|mutation:716-716	flag tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9NPB6	uniprotkb:O14641	intact:EBI-81876|ensembl:ENSP00000219255|uniprotkb:O14911|uniprotkb:Q9NPJ7	intact:EBI-740850|ensembl:ENSP00000005340|uniprotkb:Q53XM0|uniprotkb:D3DTN3	psi-mi:par6a_human(display_long)|uniprotkb:PARD6A(gene name)|psi-mi:PARD6A(display_short)|uniprotkb:PAR6A(gene name synonym)|uniprotkb:PAR6C(gene name synonym)|uniprotkb:Tax interaction protein 40(gene name synonym)	psi-mi:dvl2_human(display_long)|uniprotkb:DSH homolog 2(gene name synonym)|uniprotkb:DVL2(gene name)|psi-mi:DVL2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Narimatsu et al. (2009)	imex:IM-12177|pubmed:19379695	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2348586|imex:IM-12177-16	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000102981(gene)|ensembl:ENST00000219255(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0005938"(cell cortex)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016032"(viral process)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0045217"(cell-cell junction maintenance)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0051301"(cell division)|go:"GO:0060341"(regulation of cellular localization)|go:"GO:1904781"(positive regulation of protein localization to centrosome)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR034868|interpro:IPR034872|interpro:IPR036034|mint:Q9NPB6|rcsb pdb:1WMH|reactome:R-HSA-2173791|reactome:R-HSA-420029|reactome:R-HSA-4608870|reactome:R-HSA-9013148|go:"GO:0034451"(centriolar satellite)|reactome:R-HSA-9013149|refseq:NP_001032358.1|refseq:NP_058644.1|dip:DIP-31312N	refseq:NP_004413.1|ensembl:ENSG00000004975(gene)|ensembl:ENST00000005340(transcript)|go:"GO:0001843"(neural tube closure)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0005109"(frizzled binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007379"(segment specification)|go:"GO:0007507"(heart development)|go:"GO:0016235"(aggresome)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022007"(convergent extension involved in neural plate elongation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035567"(non-canonical Wnt signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0044340"(canonical Wnt signaling pathway involved in regulation of cell proliferation)|go:"GO:0045177"(apical part of cell)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0090179"(planar cell polarity pathway involved in neural tube closure)|go:"GO:0150012"(positive regulation of neuron projection arborization)|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|interpro:IPR001158(DIX)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR003351(Dishevelled protein)|interpro:IPR008339(Dishevelled region)|interpro:IPR008341(Dishevelled-2 region)|interpro:IPR015506(Dishevelled related protein)|interpro:IPR024580|interpro:IPR029071|interpro:IPR036034|interpro:IPR036388|interpro:IPR036390|interpro:IPR038207|mint:O14641|rcsb pdb:2REY|rcsb pdb:3CBX|rcsb pdb:3CBY|rcsb pdb:3CBZ|rcsb pdb:3CC0|rcsb pdb:4WIP|rcsb pdb:5LNP|rcsb pdb:5SUY|rcsb pdb:5SUZ|rcsb pdb:6IW3|rcsb pdb:6JCK|reactome:R-HSA-201681|reactome:R-HSA-201688|reactome:R-HSA-2028269|reactome:R-HSA-4086400|reactome:R-HSA-4608870|reactome:R-HSA-4641258|reactome:R-HSA-4641262|reactome:R-HSA-5099900|reactome:R-HSA-5368598|reactome:R-HSA-5663220|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-9673324|ensembl:ENSP00000005340|dip:DIP-34433N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 4B|comment:Par6 interacted with Dvl2 irrespective of the presence or absence of Wnt5A.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mda_mb_231)|taxid:9606(Homo sapiens Caucasian breast adenocarcinoma)	-	2009/05/28	2014/10/16	rogid:QvPdZFaXbWyVMe/qycVjq8xtybY9606	rogid:2Vdc8oRnT4Mz/j+EXQXrL3AszOc9606	intact-crc:0145109827925C3E|rigid:tx/jt0Kal5byC2hDNJ1BfBXVS+Q	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q9NPB6	uniprotkb:Q9HAU4	intact:EBI-81876|ensembl:ENSP00000219255|uniprotkb:O14911|uniprotkb:Q9NPJ7	intact:EBI-396727|uniprotkb:Q52LL1|uniprotkb:Q9H260|ensembl:ENSP00000262435	psi-mi:par6a_human(display_long)|uniprotkb:PARD6A(gene name)|psi-mi:PARD6A(display_short)|uniprotkb:PAR6A(gene name synonym)|uniprotkb:PAR6C(gene name synonym)|uniprotkb:Tax interaction protein 40(gene name synonym)	psi-mi:smuf2_human(display_long)|uniprotkb:SMURF2(gene name)|psi-mi:SMURF2(display_short)|uniprotkb:SMAD ubiquitination regulatory factor 2(gene name synonym)|uniprotkb:SMAD-specific E3 ubiquitin-protein ligase 2(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase SMURF2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Narimatsu et al. (2009)	imex:IM-12177|pubmed:19379695	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2348592|imex:IM-12177-15	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000102981(gene)|ensembl:ENST00000219255(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0005938"(cell cortex)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016032"(viral process)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0045217"(cell-cell junction maintenance)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0051301"(cell division)|go:"GO:0060341"(regulation of cellular localization)|go:"GO:1904781"(positive regulation of protein localization to centrosome)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR034868|interpro:IPR034872|interpro:IPR036034|mint:Q9NPB6|rcsb pdb:1WMH|reactome:R-HSA-2173791|reactome:R-HSA-420029|reactome:R-HSA-4608870|reactome:R-HSA-9013148|go:"GO:0034451"(centriolar satellite)|reactome:R-HSA-9013149|refseq:NP_001032358.1|refseq:NP_058644.1|dip:DIP-31312N	refseq:NP_073576.1|ensembl:ENSG00000108854(gene)|ensembl:ENST00000262435(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016607"(nuclear speck)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046332"(SMAD binding)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|mint:Q9HAU4|rcsb pdb:1ZVD|rcsb pdb:2DJY|rcsb pdb:2JQZ|rcsb pdb:2KXQ|rcsb pdb:2LTZ|rcsb pdb:6FX4|rcsb pdb:7M3Q|reactome:R-HSA-201451|reactome:R-HSA-2173788|reactome:R-HSA-2173795|reactome:R-HSA-4608870|reactome:R-HSA-4641257|reactome:R-HSA-5632684|reactome:R-HSA-5689880|reactome:R-HSA-8941858|reactome:R-HSA-983168|dip:DIP-33061N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 4B|comment:The interaction of endogenous Smurf2 with Par6 required Wnt5A stimulation.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-mda_mb_231)|taxid:9606(Homo sapiens Caucasian breast adenocarcinoma)	-	2009/05/28	2014/10/16	rogid:QvPdZFaXbWyVMe/qycVjq8xtybY9606	rogid:Ch9UvXcmtb2iD8i9DVKGCe77J7k9606	intact-crc:EA5320539B2B5146|rigid:inOIOXJMrtchSUwsfxJScoiPSO0	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:O14641	uniprotkb:Q9Z101	intact:EBI-740850|ensembl:ENSP00000005340|uniprotkb:Q53XM0|uniprotkb:D3DTN3	intact:EBI-81732|uniprotkb:Q5RL03|uniprotkb:Q6P8R2|ensembl:ENSMUSP00000090886	psi-mi:dvl2_human(display_long)|uniprotkb:DSH homolog 2(gene name synonym)|uniprotkb:DVL2(gene name)|psi-mi:DVL2(display_short)	psi-mi:par6a_mouse(display_long)|uniprotkb:Pard6a(gene name)|psi-mi:Pard6a(display_short)|uniprotkb:Par6a(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Narimatsu et al. (2009)	imex:IM-12177|pubmed:19379695	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2348605|imex:IM-12177-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004413.1|ensembl:ENSG00000004975(gene)|ensembl:ENST00000005340(transcript)|go:"GO:0001843"(neural tube closure)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0005109"(frizzled binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007379"(segment specification)|go:"GO:0007507"(heart development)|go:"GO:0016235"(aggresome)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022007"(convergent extension involved in neural plate elongation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035567"(non-canonical Wnt signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0044340"(canonical Wnt signaling pathway involved in regulation of cell proliferation)|go:"GO:0045177"(apical part of cell)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0090179"(planar cell polarity pathway involved in neural tube closure)|go:"GO:0150012"(positive regulation of neuron projection arborization)|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|interpro:IPR001158(DIX)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR003351(Dishevelled protein)|interpro:IPR008339(Dishevelled region)|interpro:IPR008341(Dishevelled-2 region)|interpro:IPR015506(Dishevelled related protein)|interpro:IPR024580|interpro:IPR029071|interpro:IPR036034|interpro:IPR036388|interpro:IPR036390|interpro:IPR038207|mint:O14641|rcsb pdb:2REY|rcsb pdb:3CBX|rcsb pdb:3CBY|rcsb pdb:3CBZ|rcsb pdb:3CC0|rcsb pdb:4WIP|rcsb pdb:5LNP|rcsb pdb:5SUY|rcsb pdb:5SUZ|rcsb pdb:6IW3|rcsb pdb:6JCK|reactome:R-HSA-201681|reactome:R-HSA-201688|reactome:R-HSA-2028269|reactome:R-HSA-4086400|reactome:R-HSA-4608870|reactome:R-HSA-4641258|reactome:R-HSA-4641262|reactome:R-HSA-5099900|reactome:R-HSA-5368598|reactome:R-HSA-5663220|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-9673324|ensembl:ENSP00000005340|dip:DIP-34433N	refseq:NP_001040900.1|refseq:NP_062669.2|ensembl:ENSMUSG00000005699(gene)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0005938"(cell cortex)|ensembl:ENSMUST00000093195(transcript)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030054"(cell junction)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034451"(centriolar satellite)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045217"(cell-cell junction maintenance)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0051301"(cell division)|go:"GO:0060341"(regulation of cellular localization)|go:"GO:1904781"(positive regulation of protein localization to centrosome)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR034868|interpro:IPR034872|interpro:IPR036034|reactome:R-MMU-2173791|reactome:R-MMU-420029|reactome:R-MMU-4608870|reactome:R-MMU-9013148|reactome:R-MMU-9013149|dip:DIP-32553N	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 4C|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2009/05/28	2014/10/16	rogid:2Vdc8oRnT4Mz/j+EXQXrL3AszOc9606	rogid:gmmbxc9dNybdFr3Tf6e8lN5H/vQ10090	intact-crc:E01C4D60CC93B70A|rigid:GOUhR0RiGDkl9gZ4LszFV4Hs+uw	false	flag tag:?-?|mutation decreasing interaction:499-499	ha tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O14641	uniprotkb:A2A5Z6	intact:EBI-740850|ensembl:ENSP00000005340|uniprotkb:Q53XM0|uniprotkb:D3DTN3	intact:EBI-2348309|uniprotkb:A2A5Z7|uniprotkb:Q5IRE6|ensembl:ENSMUSP00000090177|ensembl:ENSMUSP00000129269	psi-mi:dvl2_human(display_long)|uniprotkb:DSH homolog 2(gene name synonym)|uniprotkb:DVL2(gene name)|psi-mi:DVL2(display_short)	psi-mi:smuf2_mouse(display_long)|uniprotkb:Smurf2(gene name)|psi-mi:Smurf2(display_short)|uniprotkb:SMAD ubiquitination regulatory factor 2(gene name synonym)|uniprotkb:SMAD-specific E3 ubiquitin-protein ligase 2(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase SMURF2(gene name synonym)	psi-mi:"MI:0676"(tandem affinity purification)	Narimatsu et al. (2009)	imex:IM-12177|pubmed:19379695	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2348605|imex:IM-12177-17	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_004413.1|ensembl:ENSG00000004975(gene)|ensembl:ENST00000005340(transcript)|go:"GO:0001843"(neural tube closure)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0005109"(frizzled binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007379"(segment specification)|go:"GO:0007507"(heart development)|go:"GO:0016235"(aggresome)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022007"(convergent extension involved in neural plate elongation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035567"(non-canonical Wnt signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0044340"(canonical Wnt signaling pathway involved in regulation of cell proliferation)|go:"GO:0045177"(apical part of cell)|go:"GO:0045334"(clathrin-coated endocytic vesicle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0090179"(planar cell polarity pathway involved in neural tube closure)|go:"GO:0150012"(positive regulation of neuron projection arborization)|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|interpro:IPR001158(DIX)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR003351(Dishevelled protein)|interpro:IPR008339(Dishevelled region)|interpro:IPR008341(Dishevelled-2 region)|interpro:IPR015506(Dishevelled related protein)|interpro:IPR024580|interpro:IPR029071|interpro:IPR036034|interpro:IPR036388|interpro:IPR036390|interpro:IPR038207|mint:O14641|rcsb pdb:2REY|rcsb pdb:3CBX|rcsb pdb:3CBY|rcsb pdb:3CBZ|rcsb pdb:3CC0|rcsb pdb:4WIP|rcsb pdb:5LNP|rcsb pdb:5SUY|rcsb pdb:5SUZ|rcsb pdb:6IW3|rcsb pdb:6JCK|reactome:R-HSA-201681|reactome:R-HSA-201688|reactome:R-HSA-2028269|reactome:R-HSA-4086400|reactome:R-HSA-4608870|reactome:R-HSA-4641258|reactome:R-HSA-4641262|reactome:R-HSA-5099900|reactome:R-HSA-5368598|reactome:R-HSA-5663220|reactome:R-HSA-8856825|reactome:R-HSA-8856828|reactome:R-HSA-9673324|ensembl:ENSP00000005340|dip:DIP-34433N	refseq:NP_079757.2|refseq:XP_006533999.1|ensembl:ENSMUSG00000018363(gene)|ensembl:ENSMUST00000092517(transcript)|ensembl:ENSMUST00000167787(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005160"(transforming growth factor beta receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016607"(nuclear speck)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046332"(SMAD binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000569(HECT)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR024928|interpro:IPR035892|interpro:IPR035983|interpro:IPR036020|reactome:R-MMU-201451|reactome:R-MMU-2173788|reactome:R-MMU-2173795|reactome:R-MMU-4608870|reactome:R-MMU-4641257|reactome:R-MMU-5632684|reactome:R-MMU-5689880|reactome:R-MMU-8941858|reactome:R-MMU-983168	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 4C|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2009/05/28	2014/10/16	rogid:2Vdc8oRnT4Mz/j+EXQXrL3AszOc9606	rogid:a+mJTESi3rlZ5TMmGrZSxYo5FkM10090	intact-crc:E01C4D60CC93B70A|rigid:GOUhR0RiGDkl9gZ4LszFV4Hs+uw	false	flag tag:?-?|mutation decreasing interaction:499-499	mutation:716-716|myc tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9Z101	uniprotkb:O00254	intact:EBI-81732|uniprotkb:Q5RL03|uniprotkb:Q6P8R2|ensembl:ENSMUSP00000090886	intact:EBI-1751853|uniprotkb:Q7Z3W3|uniprotkb:Q52M68|uniprotkb:B2R754|uniprotkb:B4DQ13|ensembl:ENSP00000296641	psi-mi:par6a_mouse(display_long)|uniprotkb:Pard6a(gene name)|psi-mi:Pard6a(display_short)|uniprotkb:Par6a(gene name synonym)	psi-mi:par3_human(display_long)|uniprotkb:F2RL2(gene name)|psi-mi:F2RL2(display_short)|uniprotkb:PAR3(gene name synonym)|uniprotkb:Thrombin receptor-like 2(gene name synonym)|uniprotkb:Coagulation factor II receptor-like 2(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Narimatsu et al. (2009)	imex:IM-12177|pubmed:19379695	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2349013|imex:IM-12177-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001040900.1|refseq:NP_062669.2|ensembl:ENSMUSG00000005699(gene)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0005938"(cell cortex)|ensembl:ENSMUST00000093195(transcript)|go:"GO:0007098"(centrosome cycle)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030054"(cell junction)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034451"(centriolar satellite)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045217"(cell-cell junction maintenance)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0051301"(cell division)|go:"GO:0060341"(regulation of cellular localization)|go:"GO:1904781"(positive regulation of protein localization to centrosome)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR034868|interpro:IPR034872|interpro:IPR036034|reactome:R-MMU-2173791|reactome:R-MMU-420029|reactome:R-MMU-4608870|reactome:R-MMU-9013148|reactome:R-MMU-9013149|dip:DIP-32553N	refseq:NP_004092.1|refseq:NP_001243495.1|dip:DIP-44337N|ensembl:ENSG00000164220(gene)|ensembl:ENST00000296641(transcript)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004930"(G protein-coupled receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007596"(blood coagulation)|go:"GO:0009611"(response to wounding)|go:"GO:0015057"(thrombin-activated receptor activity)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030168"(platelet activation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0051482"(positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR003912(Protease-activated receptor)|interpro:IPR003943(Protease-activated receptor 3)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|mint:O00254|reactome:R-HSA-375276|reactome:R-HSA-416476|reactome:R-HSA-456926	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supp. Fig. 7C|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293t)|taxid:9606(Homo sapiens 293 cells transformed with SV40 large T antigen)	-	2009/05/28	2014/10/16	rogid:gmmbxc9dNybdFr3Tf6e8lN5H/vQ10090	rogid:IaQ9JZBcSATjZ9nsKn3wwnHBICo9606	intact-crc:B940B35FC784EFFC|rigid:lIA93pBbHFYO4UAfw+A7H/P/oxc	false	sufficient binding region:296-346,1-249|flag tag:?-?	flag tag:?-?	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)