#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9GZX6	uniprotkb:Q969J5	intact:EBI-8040250|intact:MINT-6693924|ensembl:ENSP00000329384|ensembl:ENSP00000442424	intact:EBI-8591719|ensembl:ENSP00000296980|uniprotkb:Q08AH7|uniprotkb:Q96QR0|uniprotkb:Q6UWM1|intact:MINT-7010488|uniprotkb:Q96A41	psi-mi:il22_human(display_long)|uniprotkb:IL22(gene name)|psi-mi:IL22(display_short)|uniprotkb:ILTIF(gene name synonym)|uniprotkb:UNQ3099/PRO10096(orf name)|uniprotkb:ZCYTO18(gene name synonym)|uniprotkb:IL-10-related T-cell-derived-inducible factor(gene name synonym)|uniprotkb:Cytokine Zcyto18(gene name synonym)	psi-mi:i22r2_human(display_long)|uniprotkb:IL22RA2(gene name)|psi-mi:IL22RA2(display_short)|uniprotkb:Interleukin-22-binding protein(gene name synonym)|uniprotkb:UNQ5793/PRO19598/PRO19822(orf name)|uniprotkb:Cytokine receptor family 2 member 10(gene name synonym)|uniprotkb:Cytokine receptor class-II member 10(gene name synonym)|uniprotkb:Cytokine receptor family type 2, soluble 1(gene name synonym)|uniprotkb:ZcytoR16(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	de et al. (2009)	mint:MINT-7010467|pubmed:19285080|doi:10.1016/j.febslet.2009.03.006|mint:d-09-00171	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8591714|mint:MINT-7010533	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_065386.1|dip:DIP-46035N|ensembl:ENSG00000127318(gene)|ensembl:ENST00000328087(transcript)|ensembl:ENST00000538666(transcript)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006953"(acute-phase response)|go:"GO:0006954"(inflammatory response)|go:"GO:0045518"(interleukin-22 receptor binding)|go:"GO:0051384"(response to glucocorticoid)|interpro:IPR009079(Four-helical cytokine-like, core)|interpro:IPR020423|interpro:IPR020453|mint:Q9GZX6|rcsb pdb:1M4R|rcsb pdb:1YKB|rcsb pdb:3DGC|rcsb pdb:3DLQ|rcsb pdb:3G9V|rcsb pdb:3Q1S|reactome:R-HSA-8854691|mint:MINT-7010535(identity)	ensembl:ENSG00000164485(gene)|ensembl:ENST00000296980(transcript)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0042017"(interleukin-22 binding)|go:"GO:0042018"(interleukin-22 receptor activity)|go:"GO:0042509"(regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0050728"(negative regulation of inflammatory response)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015373(Interferon-alpha/beta receptor, fibronectin type III)|interpro:IPR036116|mint:Q969J5|rcsb pdb:3G9V|reactome:R-HSA-8854691|refseq:NP_443194.1|refseq:NP_851827.1|refseq:NP_851826.1|dip:DIP-46036N|mint:MINT-7010536(identity)	-	function:Cytokine that contributes to the inflammatory response in vivo|comment:mint	function:"Isoform 2 is a receptor for IL22. Binds to IL22, prevents interaction with the functional IL-22R complex and blocks the activity of IL22 (in vitro). May play an important role as an IL22 antagonist in the regulation of inflammatory responses. Isoform 1 may play a role in establishing and maintaining successful pregnancy"|comment:mint	figure legend:F1|comment:homomint|comment:mint	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/03/05	2014/10/16	rogid:yeLvTpHRMJWT0niv9ttASw0PkZU9606	rogid:HoOE3pGPkA/9Pplg8wPXJhgTdGM9606	intact-crc:8197EB53B77040C9|rigid:tW0mXEDHCt6lm4hfOlQNP4KAxFs	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)