#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q17941 uniprotkb:O18178 intact:EBI-1770718|uniprotkb:Q17942|uniprotkb:Q8MQE0|ensemblmetazoa:C12D8.10a.1|ensemblmetazoa:C12D8.10a.2 intact:EBI-2298122|ensemblmetazoa:W08G11.4.1 psi-mi:akt1_caeel(display_long)|uniprotkb:akt-1(gene name)|psi-mi:akt-1(display_short)|uniprotkb:C12D8.10(orf name)|uniprotkb:Protein kinase B akt-1(gene name synonym) psi-mi:2a51_caeel(display_long)|uniprotkb:pptr-1(gene name)|psi-mi:pptr-1(display_short)|uniprotkb:Serine/threonine-protein phosphatase 2A 56kDa regulatory subunit pptr-1(gene name synonym)|uniprotkb:Serine/threonine-protein phosphatase 2A regulatory subunit B' pptr-1(gene name synonym)|uniprotkb:W08G11.4(orf name) psi-mi:"MI:0416"(fluorescence microscopy) Padmanabhan et al. (2009) imex:IM-12074|pubmed:19249087 taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0469"(IntAct) intact:EBI-2298132|imex:IM-12074-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001023645.1|refseq:NP_001023646.1|refseq:NP_001023647.1|wormbase:C12D8.10a|wormbase:C12D8.10b|wormbase:C12D8.10c|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017892|interpro:IPR001849(Pleckstrin-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR039026|mint:Q17941|ensemblmetazoa:C12D8.10a.1(transcript)|ensemblmetazoa:C12D8.10a.2(transcript)|ensemblmetazoa:WBGene00000102(gene)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006935"(chemotaxis)|go:"GO:0007635"(chemosensory behavior)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008582"(regulation of synaptic assembly at neuromuscular junction)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902074"(response to salt)|reactome:R-CEL-1257604|reactome:R-CEL-1474151|reactome:R-CEL-165158|reactome:R-CEL-165159|reactome:R-CEL-198323|reactome:R-CEL-198693|reactome:R-CEL-199418|reactome:R-CEL-203615|reactome:R-CEL-211163|reactome:R-CEL-389357|reactome:R-CEL-389513|reactome:R-CEL-392451|reactome:R-CEL-450385|reactome:R-CEL-450604|reactome:R-CEL-5218920|reactome:R-CEL-6811558|reactome:R-CEL-69202|reactome:R-CEL-69656|reactome:R-CEL-8849469|reactome:R-CEL-8876198|reactome:R-CEL-8948751|reactome:R-CEL-9009391|reactome:R-CEL-9604323|reactome:R-CEL-9607240|reactome:R-CEL-9614399|reactome:R-CEL-9634638 interpro:IPR011989(Armadillo-like helical)|wormbase:W08G11.4|interpro:IPR016024(Armadillo-type fold)|interpro:IPR002554(Protein phosphatase 2A, regulatory B subunit, B56)|refseq:NP_507133.4|reactome:R-CEL-195253|reactome:R-CEL-5673000|reactome:R-CEL-5675221|reactome:R-CEL-196299|reactome:R-CEL-389513|reactome:R-CEL-6811558|ensemblmetazoa:W08G11.4.1(transcript)|ensemblmetazoa:WBGene00012348(gene)|go:"GO:0000159"(protein phosphatase type 2A complex)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009408"(response to heat)|go:"GO:0010883"(regulation of lipid storage)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031952"(regulation of protein autophosphorylation)|go:"GO:0040024"(dauer larval development)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1903863"(P granule assembly) psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) - 2009/04/01 2014/10/16 rogid:Lbru/j15mbtFfQv0kZ3xFS+32Hs6239 rogid:eaIHZiW9csy2x2ns4z9TWcFvh7E6239 intact-crc:C0009F8202C05C27|rigid:S/P4xDS50QARidrx2T4OQq851q4 false green fluorescent protein tag:?-? red fluorescent protein tag:?-?|flag tag:?-? - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:Q9XTG7 uniprotkb:O18178 intact:EBI-320656|uniprotkb:O77145|ensemblmetazoa:F28H6.1a.1 intact:EBI-2298122|ensemblmetazoa:W08G11.4.1 psi-mi:akt2_caeel(display_long)|uniprotkb:akt-2(gene name)|psi-mi:akt-2(display_short)|uniprotkb:Protein kinase B akt-2(gene name synonym)|uniprotkb:F28H6.1(orf name) psi-mi:2a51_caeel(display_long)|uniprotkb:pptr-1(gene name)|psi-mi:pptr-1(display_short)|uniprotkb:Serine/threonine-protein phosphatase 2A 56kDa regulatory subunit pptr-1(gene name synonym)|uniprotkb:Serine/threonine-protein phosphatase 2A regulatory subunit B' pptr-1(gene name synonym)|uniprotkb:W08G11.4(orf name) psi-mi:"MI:0416"(fluorescence microscopy) Padmanabhan et al. (2009) imex:IM-12074|pubmed:19249087 taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) psi-mi:"MI:0403"(colocalization) psi-mi:"MI:0469"(IntAct) intact:EBI-2298146|imex:IM-12074-2 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_510357.3|wormbase:F28H6.1a|wormbase:F28H6.1b|reactome:R-CEL-392451|refseq:NP_001024612.1|ensemblmetazoa:F28H6.1a.1(transcript)|ensemblmetazoa:WBGene00000103(gene)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008582"(regulation of synaptic assembly at neuromuscular junction)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0046872"(metal ion binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR039026|go:"GO:0045087"(innate immune response)|reactome:R-CEL-165158|reactome:R-CEL-1257604|reactome:R-CEL-198323|reactome:R-CEL-198693|reactome:R-CEL-199418|reactome:R-CEL-389357|reactome:R-CEL-5218920|dip:DIP-26368N|reactome:R-CEL-9634638|reactome:R-CEL-211163|reactome:R-CEL-69202|reactome:R-CEL-69656|reactome:R-CEL-8876198|reactome:R-CEL-8948751|reactome:R-CEL-9614399|reactome:R-CEL-1474151|reactome:R-CEL-165159|reactome:R-CEL-203615|reactome:R-CEL-389513|reactome:R-CEL-450385|reactome:R-CEL-450604|reactome:R-CEL-6811558|reactome:R-CEL-8849469|reactome:R-CEL-9009391|reactome:R-CEL-9604323|reactome:R-CEL-9607240 interpro:IPR011989(Armadillo-like helical)|wormbase:W08G11.4|interpro:IPR016024(Armadillo-type fold)|interpro:IPR002554(Protein phosphatase 2A, regulatory B subunit, B56)|refseq:NP_507133.4|reactome:R-CEL-195253|reactome:R-CEL-5673000|reactome:R-CEL-5675221|reactome:R-CEL-196299|reactome:R-CEL-389513|reactome:R-CEL-6811558|ensemblmetazoa:W08G11.4.1(transcript)|ensemblmetazoa:WBGene00012348(gene)|go:"GO:0000159"(protein phosphatase type 2A complex)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009408"(response to heat)|go:"GO:0010883"(regulation of lipid storage)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031952"(regulation of protein autophosphorylation)|go:"GO:0040024"(dauer larval development)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1903863"(P granule assembly) psi-mi:"MI:0469"(intact) - - figure legend:Fig. 3B|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) - 2009/04/01 2014/10/16 rogid:Y8D47LHcNyTK3JpkYGj9/UCRYKs6239 rogid:eaIHZiW9csy2x2ns4z9TWcFvh7E6239 intact-crc:0E3177DE512E326D|rigid:FzJguCPvgKgXTvgZPUqWRQcAIKg false green fluorescent protein tag:?-? flag tag:?-?|red fluorescent protein tag:?-? - - psi-mi:"MI:0867"(tag visualisation by fluorescence) psi-mi:"MI:0867"(tag visualisation by fluorescence) uniprotkb:Q17941 uniprotkb:O18178 intact:EBI-1770718|uniprotkb:Q17942|uniprotkb:Q8MQE0|ensemblmetazoa:C12D8.10a.1|ensemblmetazoa:C12D8.10a.2 intact:EBI-2298122|ensemblmetazoa:W08G11.4.1 psi-mi:akt1_caeel(display_long)|uniprotkb:akt-1(gene name)|psi-mi:akt-1(display_short)|uniprotkb:C12D8.10(orf name)|uniprotkb:Protein kinase B akt-1(gene name synonym) psi-mi:2a51_caeel(display_long)|uniprotkb:pptr-1(gene name)|psi-mi:pptr-1(display_short)|uniprotkb:Serine/threonine-protein phosphatase 2A 56kDa regulatory subunit pptr-1(gene name synonym)|uniprotkb:Serine/threonine-protein phosphatase 2A regulatory subunit B' pptr-1(gene name synonym)|uniprotkb:W08G11.4(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Padmanabhan et al. (2009) imex:IM-12074|pubmed:19249087 taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2298198|imex:IM-12074-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001023645.1|refseq:NP_001023646.1|refseq:NP_001023647.1|wormbase:C12D8.10a|wormbase:C12D8.10b|wormbase:C12D8.10c|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017892|interpro:IPR001849(Pleckstrin-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR039026|mint:Q17941|ensemblmetazoa:C12D8.10a.1(transcript)|ensemblmetazoa:C12D8.10a.2(transcript)|ensemblmetazoa:WBGene00000102(gene)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006935"(chemotaxis)|go:"GO:0007635"(chemosensory behavior)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008582"(regulation of synaptic assembly at neuromuscular junction)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902074"(response to salt)|reactome:R-CEL-1257604|reactome:R-CEL-1474151|reactome:R-CEL-165158|reactome:R-CEL-165159|reactome:R-CEL-198323|reactome:R-CEL-198693|reactome:R-CEL-199418|reactome:R-CEL-203615|reactome:R-CEL-211163|reactome:R-CEL-389357|reactome:R-CEL-389513|reactome:R-CEL-392451|reactome:R-CEL-450385|reactome:R-CEL-450604|reactome:R-CEL-5218920|reactome:R-CEL-6811558|reactome:R-CEL-69202|reactome:R-CEL-69656|reactome:R-CEL-8849469|reactome:R-CEL-8876198|reactome:R-CEL-8948751|reactome:R-CEL-9009391|reactome:R-CEL-9604323|reactome:R-CEL-9607240|reactome:R-CEL-9614399|reactome:R-CEL-9634638 interpro:IPR011989(Armadillo-like helical)|wormbase:W08G11.4|interpro:IPR016024(Armadillo-type fold)|interpro:IPR002554(Protein phosphatase 2A, regulatory B subunit, B56)|refseq:NP_507133.4|reactome:R-CEL-195253|reactome:R-CEL-5673000|reactome:R-CEL-5675221|reactome:R-CEL-196299|reactome:R-CEL-389513|reactome:R-CEL-6811558|ensemblmetazoa:W08G11.4.1(transcript)|ensemblmetazoa:WBGene00012348(gene)|go:"GO:0000159"(protein phosphatase type 2A complex)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009408"(response to heat)|go:"GO:0010883"(regulation of lipid storage)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031952"(regulation of protein autophosphorylation)|go:"GO:0040024"(dauer larval development)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1903863"(P granule assembly) psi-mi:"MI:0469"(intact) - - comment:PPTR-1 directly interacts with AKT-1 in C. elegans.|figure legend:Fig. 4A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) - 2009/04/01 2014/10/16 rogid:Lbru/j15mbtFfQv0kZ3xFS+32Hs6239 rogid:eaIHZiW9csy2x2ns4z9TWcFvh7E6239 intact-crc:54D108B756C99452|rigid:S/P4xDS50QARidrx2T4OQq851q4 false green fluorescent protein tag:?-? flag tag:?-?|red fluorescent protein tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q17941 uniprotkb:O18178 intact:EBI-1770718|uniprotkb:Q17942|uniprotkb:Q8MQE0|ensemblmetazoa:C12D8.10a.1|ensemblmetazoa:C12D8.10a.2 intact:EBI-2298122|ensemblmetazoa:W08G11.4.1 psi-mi:akt1_caeel(display_long)|uniprotkb:akt-1(gene name)|psi-mi:akt-1(display_short)|uniprotkb:C12D8.10(orf name)|uniprotkb:Protein kinase B akt-1(gene name synonym) psi-mi:2a51_caeel(display_long)|uniprotkb:pptr-1(gene name)|psi-mi:pptr-1(display_short)|uniprotkb:Serine/threonine-protein phosphatase 2A 56kDa regulatory subunit pptr-1(gene name synonym)|uniprotkb:Serine/threonine-protein phosphatase 2A regulatory subunit B' pptr-1(gene name synonym)|uniprotkb:W08G11.4(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Padmanabhan et al. (2009) imex:IM-12074|pubmed:19249087 taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2298217|imex:IM-12074-4 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001023645.1|refseq:NP_001023646.1|refseq:NP_001023647.1|wormbase:C12D8.10a|wormbase:C12D8.10b|wormbase:C12D8.10c|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017892|interpro:IPR001849(Pleckstrin-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR039026|mint:Q17941|ensemblmetazoa:C12D8.10a.1(transcript)|ensemblmetazoa:C12D8.10a.2(transcript)|ensemblmetazoa:WBGene00000102(gene)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006935"(chemotaxis)|go:"GO:0007635"(chemosensory behavior)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0008582"(regulation of synaptic assembly at neuromuscular junction)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045087"(innate immune response)|go:"GO:0046872"(metal ion binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1902074"(response to salt)|reactome:R-CEL-1257604|reactome:R-CEL-1474151|reactome:R-CEL-165158|reactome:R-CEL-165159|reactome:R-CEL-198323|reactome:R-CEL-198693|reactome:R-CEL-199418|reactome:R-CEL-203615|reactome:R-CEL-211163|reactome:R-CEL-389357|reactome:R-CEL-389513|reactome:R-CEL-392451|reactome:R-CEL-450385|reactome:R-CEL-450604|reactome:R-CEL-5218920|reactome:R-CEL-6811558|reactome:R-CEL-69202|reactome:R-CEL-69656|reactome:R-CEL-8849469|reactome:R-CEL-8876198|reactome:R-CEL-8948751|reactome:R-CEL-9009391|reactome:R-CEL-9604323|reactome:R-CEL-9607240|reactome:R-CEL-9614399|reactome:R-CEL-9634638 interpro:IPR011989(Armadillo-like helical)|wormbase:W08G11.4|interpro:IPR016024(Armadillo-type fold)|interpro:IPR002554(Protein phosphatase 2A, regulatory B subunit, B56)|refseq:NP_507133.4|reactome:R-CEL-195253|reactome:R-CEL-5673000|reactome:R-CEL-5675221|reactome:R-CEL-196299|reactome:R-CEL-389513|reactome:R-CEL-6811558|ensemblmetazoa:W08G11.4.1(transcript)|ensemblmetazoa:WBGene00012348(gene)|go:"GO:0000159"(protein phosphatase type 2A complex)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009408"(response to heat)|go:"GO:0010883"(regulation of lipid storage)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031952"(regulation of protein autophosphorylation)|go:"GO:0040024"(dauer larval development)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1903863"(P granule assembly) psi-mi:"MI:0469"(intact) - - figure legend:Fig. 4A, Supp. Fig. 3|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) - 2009/04/01 2014/10/16 rogid:Lbru/j15mbtFfQv0kZ3xFS+32Hs6239 rogid:eaIHZiW9csy2x2ns4z9TWcFvh7E6239 intact-crc:AD48621137B9F94B|rigid:S/P4xDS50QARidrx2T4OQq851q4 false green fluorescent protein tag:?-? red fluorescent protein tag:?-?|flag tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q2PJ68 uniprotkb:O18178 intact:EBI-1770776|uniprotkb:Q2PJ69|ensemblmetazoa:W10G6.2b.1 intact:EBI-2298122|ensemblmetazoa:W08G11.4.1 psi-mi:sgk1_caeel(display_long)|uniprotkb:Serum/glucocorticoid-regulated kinase 1(gene name synonym)|uniprotkb:sgk-1(gene name)|psi-mi:sgk-1(display_short)|uniprotkb:W10G6.2(orf name)|uniprotkb:Serum- and glucocorticoid-inducible kinase homolog(gene name synonym) psi-mi:2a51_caeel(display_long)|uniprotkb:pptr-1(gene name)|psi-mi:pptr-1(display_short)|uniprotkb:Serine/threonine-protein phosphatase 2A 56kDa regulatory subunit pptr-1(gene name synonym)|uniprotkb:Serine/threonine-protein phosphatase 2A regulatory subunit B' pptr-1(gene name synonym)|uniprotkb:W08G11.4(orf name) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Padmanabhan et al. (2009) imex:IM-12074|pubmed:19249087 taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0469"(IntAct) intact:EBI-2298229|imex:IM-12074-5 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) reactome:R-CEL-6804757|refseq:NP_001041298.1|refseq:NP_001041299.1|wormbase:W10G6.2a|wormbase:W10G6.2b|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|reactome:R-CEL-2672351|reactome:R-CEL-9031628|ensemblmetazoa:W10G6.2b.1(transcript)|ensemblmetazoa:WBGene00004789(gene)|go:"GO:0002119"(nematode larval development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0044255"(cellular lipid metabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0048382"(mesendoderm development)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903188"(positive regulation of vitellogenesis)|go:"GO:1904508"(regulation of protein localization to basolateral plasma membrane) interpro:IPR011989(Armadillo-like helical)|wormbase:W08G11.4|interpro:IPR016024(Armadillo-type fold)|interpro:IPR002554(Protein phosphatase 2A, regulatory B subunit, B56)|refseq:NP_507133.4|reactome:R-CEL-195253|reactome:R-CEL-5673000|reactome:R-CEL-5675221|reactome:R-CEL-196299|reactome:R-CEL-389513|reactome:R-CEL-6811558|ensemblmetazoa:W08G11.4.1(transcript)|ensemblmetazoa:WBGene00012348(gene)|go:"GO:0000159"(protein phosphatase type 2A complex)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007165"(signal transduction)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009408"(response to heat)|go:"GO:0010883"(regulation of lipid storage)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031952"(regulation of protein autophosphorylation)|go:"GO:0040024"(dauer larval development)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:1903863"(P granule assembly) psi-mi:"MI:0469"(intact) - - figure legend:Supp. Fig. 3|caution:This interaction was not confirmed by either genetic or colocalisation data.|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:6239(caeel)|taxid:6239(Caenorhabditis elegans) - 2009/04/01 2014/10/16 rogid:ngczdO33Sry0fNHG63cFjKsegn46239 rogid:eaIHZiW9csy2x2ns4z9TWcFvh7E6239 intact-crc:B0413DBCFCAB4143|rigid:viW8tYTV9//LsKPdTC+Y+sVHwio false green fluorescent protein tag:?-? red fluorescent protein tag:?-?|flag tag:?-? - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot)