#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:O00238	uniprotkb:P43026	intact:EBI-7527193|uniprotkb:P78366|uniprotkb:B2R953|uniprotkb:B4DSV1|intact:MINT-1340235|ensembl:ENSP00000264568|ensembl:ENSP00000378389|ensembl:ENSP00000421671|ensembl:ENSP00000425444|ensembl:ENSP00000426617|ensembl:ENSP00000500035	intact:EBI-8571476|ensembl:ENSP00000363489|ensembl:ENSP00000363492|uniprotkb:Q96SB1|intact:MINT-7264433|uniprotkb:E1P5Q2	psi-mi:bmr1b_human(display_long)|uniprotkb:BMPR1B(gene name)|psi-mi:BMPR1B(display_short)	psi-mi:gdf5_human(display_long)|uniprotkb:GDF5(gene name)|psi-mi:GDF5(display_short)|uniprotkb:CDMP1(gene name synonym)|uniprotkb:Cartilage-derived morphogenetic protein 1(gene name synonym)|uniprotkb:Radotermin(gene name synonym)|uniprotkb:BMP14(gene name synonym)|uniprotkb:Bone morphogenetic protein 14(gene name synonym)|uniprotkb:Lipopolysaccharide-associated protein 4(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Kotzsch et al. (2009)	mint:MINT-7263386|pubmed:19229295|imex:IM-14029|doi:10.1038/emboj.2009.37	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8571470|mint:MINT-7264457|imex:IM-14029-17	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011530503.1|refseq:NP_001194.1|refseq:NP_001243721.1|refseq:NP_001243722.1|refseq:NP_001243723.1|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0060350"(endochondral bone morphogenesis)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0098821"(BMP receptor activity)|go:"GO:0140537"(transcription regulator activator activity)|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1902731"(negative regulation of chondrocyte proliferation)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:1990712"(HFE-transferrin receptor complex)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003605(TGF beta receptor, GS motif)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:O00238|rcsb pdb:3MDY|reactome:R-HSA-201451|refseq:XP_016864047.1|refseq:XP_016864048.1|refseq:XP_016864049.1|refseq:XP_016864050.1|ensembl:ENSG00000138696(gene)|ensembl:ENST00000264568(transcript)|ensembl:ENST00000394931(transcript)|ensembl:ENST00000509540(transcript)|ensembl:ENST00000512312(transcript)|ensembl:ENST00000515059(transcript)|ensembl:ENST00000672698(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001502"(cartilage condensation)|go:"GO:0001550"(ovarian cumulus expansion)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001654"(eye development)|go:"GO:0002063"(chondrocyte development)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004675"(transmembrane receptor protein serine/threonine kinase activity)|go:"GO:0005025"(transforming growth factor beta receptor activity, type I)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0019211"(phosphatase activator activity)|go:"GO:0030166"(proteoglycan biosynthetic process)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0031290"(retinal ganglion cell axon guidance)|go:"GO:0032332"(positive regulation of chondrocyte differentiation)|go:"GO:0035108"(limb morphogenesis)|go:"GO:0036122"(BMP binding)|go:"GO:0042698"(ovulation cycle)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043235"(receptor complex)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|mint:MINT-7264459(identity)	refseq:NP_001306067.1|ensembl:ENSG00000125965(gene)|ensembl:ENST00000374369(transcript)|ensembl:ENST00000374372(transcript)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008083"(growth factor activity)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0032332"(positive regulation of chondrocyte differentiation)|go:"GO:0035136"(forelimb morphogenesis)|go:"GO:0035137"(hindlimb morphogenesis)|go:"GO:0036122"(BMP binding)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043932"(ossification involved in bone remodeling)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0060390"(regulation of SMAD protein signal transduction)|go:"GO:0060395"(SMAD protein signal transduction)|interpro:IPR001839(Transforming growth factor beta)|interpro:IPR015615(Transforming growth factor-beta-related)|interpro:IPR017948|interpro:IPR029034|mint:P43026|rcsb pdb:1WAQ|rcsb pdb:2BHK|rcsb pdb:3EVS|rcsb pdb:3QB4|rcsb pdb:5HK5|rcsb pdb:6Z3G|rcsb pdb:6Z3H|go:"GO:0060591"(chondroblast differentiation)|go:"GO:2001054"(negative regulation of mesenchymal cell apoptotic process)|interpro:IPR001111("Transforming growth factor beta (TGFb), N-terminal")|rcsb pdb:6Z3J|rcsb pdb:6Z3L|rcsb pdb:6Z3M|reactome:R-HSA-2129379|refseq:NP_000548.2|dip:DIP-5823N|refseq:XP_011527377.1|mint:MINT-7264460(identity)	-	function:"Defects in BMPR1B are a cause of brachydactyly type A2 (BDA2) [MIM:112600]. Brachydactylies (BDs) are a group of inherited malformations characterized by shortening of the digits due to abnormal development of the phalanges and/or the metacarpals. They have been classified on an anatomic and genetic basis into five groups, A to E, including three subgroups (A1 to A3) that usually manifest as autosomal dominant traits. BDA2 was described first in a large Norwegian kindred. BDA2 is caused by mutations in BMPR1B gene and studies demonstrate that these mutations function as dominant negatives in vitro and in vivo"|function:On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMPS/OP-1|comment:mint|function:"Defects in BMPR1B are the cause of acromesomelic chondrodysplasia with genital anomalies [MIM:609441]. Acromesomelic chondrodysplasias are rare hereditary skeletal disorders characterized by short stature, very short limbs, and hand/foot malformations. The severity of limb abnormalities increases from proximal to distal with profoundly affected hands and feet showing brachydactyly and/or rudimentary fingers (knob-like fingers)"	comment:mint	figure legend:F1 T1|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/09/23	2014/10/16	rogid:4R1OzI0j8xrONBb1/IXp8MOsaLc9606	rogid:1+H+MmShXRpzq5qIDid7rv8ApMk9606	intact-crc:FA1C93D36FA5FA61|rigid:ZwwaoOLCVU9mHAMPacKVxMXmW0M	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P43026	uniprotkb:O00238	intact:EBI-8571476|ensembl:ENSP00000363489|ensembl:ENSP00000363492|uniprotkb:Q96SB1|intact:MINT-7264433|uniprotkb:E1P5Q2	intact:EBI-7527193|uniprotkb:P78366|uniprotkb:B2R953|uniprotkb:B4DSV1|intact:MINT-1340235|ensembl:ENSP00000264568|ensembl:ENSP00000378389|ensembl:ENSP00000421671|ensembl:ENSP00000425444|ensembl:ENSP00000426617|ensembl:ENSP00000500035	psi-mi:gdf5_human(display_long)|uniprotkb:GDF5(gene name)|psi-mi:GDF5(display_short)|uniprotkb:CDMP1(gene name synonym)|uniprotkb:Cartilage-derived morphogenetic protein 1(gene name synonym)|uniprotkb:Radotermin(gene name synonym)|uniprotkb:BMP14(gene name synonym)|uniprotkb:Bone morphogenetic protein 14(gene name synonym)|uniprotkb:Lipopolysaccharide-associated protein 4(gene name synonym)	psi-mi:bmr1b_human(display_long)|uniprotkb:BMPR1B(gene name)|psi-mi:BMPR1B(display_short)	psi-mi:"MI:0107"(surface plasmon resonance)	Kotzsch et al. (2009)	mint:MINT-7263386|pubmed:19229295|imex:IM-14029|doi:10.1038/emboj.2009.37	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8571529|mint:MINT-7264470|imex:IM-14029-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001306067.1|ensembl:ENSG00000125965(gene)|ensembl:ENST00000374369(transcript)|ensembl:ENST00000374372(transcript)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008083"(growth factor activity)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0032332"(positive regulation of chondrocyte differentiation)|go:"GO:0035136"(forelimb morphogenesis)|go:"GO:0035137"(hindlimb morphogenesis)|go:"GO:0036122"(BMP binding)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043932"(ossification involved in bone remodeling)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0060390"(regulation of SMAD protein signal transduction)|go:"GO:0060395"(SMAD protein signal transduction)|interpro:IPR001839(Transforming growth factor beta)|interpro:IPR015615(Transforming growth factor-beta-related)|interpro:IPR017948|interpro:IPR029034|mint:P43026|rcsb pdb:1WAQ|rcsb pdb:2BHK|rcsb pdb:3EVS|rcsb pdb:3QB4|rcsb pdb:5HK5|rcsb pdb:6Z3G|rcsb pdb:6Z3H|go:"GO:0060591"(chondroblast differentiation)|go:"GO:2001054"(negative regulation of mesenchymal cell apoptotic process)|interpro:IPR001111("Transforming growth factor beta (TGFb), N-terminal")|rcsb pdb:6Z3J|rcsb pdb:6Z3L|rcsb pdb:6Z3M|reactome:R-HSA-2129379|refseq:NP_000548.2|dip:DIP-5823N|refseq:XP_011527377.1|mint:MINT-7264472(identity)	refseq:XP_011530503.1|refseq:NP_001194.1|refseq:NP_001243721.1|refseq:NP_001243722.1|refseq:NP_001243723.1|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0060350"(endochondral bone morphogenesis)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0098821"(BMP receptor activity)|go:"GO:0140537"(transcription regulator activator activity)|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1902731"(negative regulation of chondrocyte proliferation)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:1990712"(HFE-transferrin receptor complex)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003605(TGF beta receptor, GS motif)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:O00238|rcsb pdb:3MDY|reactome:R-HSA-201451|refseq:XP_016864047.1|refseq:XP_016864048.1|refseq:XP_016864049.1|refseq:XP_016864050.1|ensembl:ENSG00000138696(gene)|ensembl:ENST00000264568(transcript)|ensembl:ENST00000394931(transcript)|ensembl:ENST00000509540(transcript)|ensembl:ENST00000512312(transcript)|ensembl:ENST00000515059(transcript)|ensembl:ENST00000672698(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001502"(cartilage condensation)|go:"GO:0001550"(ovarian cumulus expansion)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001654"(eye development)|go:"GO:0002063"(chondrocyte development)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004675"(transmembrane receptor protein serine/threonine kinase activity)|go:"GO:0005025"(transforming growth factor beta receptor activity, type I)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0019211"(phosphatase activator activity)|go:"GO:0030166"(proteoglycan biosynthetic process)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0031290"(retinal ganglion cell axon guidance)|go:"GO:0032332"(positive regulation of chondrocyte differentiation)|go:"GO:0035108"(limb morphogenesis)|go:"GO:0036122"(BMP binding)|go:"GO:0042698"(ovulation cycle)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043235"(receptor complex)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|mint:MINT-7264474(identity)	-	comment:mint	function:"Defects in BMPR1B are a cause of brachydactyly type A2 (BDA2) [MIM:112600]. Brachydactylies (BDs) are a group of inherited malformations characterized by shortening of the digits due to abnormal development of the phalanges and/or the metacarpals. They have been classified on an anatomic and genetic basis into five groups, A to E, including three subgroups (A1 to A3) that usually manifest as autosomal dominant traits. BDA2 was described first in a large Norwegian kindred. BDA2 is caused by mutations in BMPR1B gene and studies demonstrate that these mutations function as dominant negatives in vitro and in vivo"|function:On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMPS/OP-1|comment:mint|function:"Defects in BMPR1B are the cause of acromesomelic chondrodysplasia with genital anomalies [MIM:609441]. Acromesomelic chondrodysplasias are rare hereditary skeletal disorders characterized by short stature, very short limbs, and hand/foot malformations. The severity of limb abnormalities increases from proximal to distal with profoundly affected hands and feet showing brachydactyly and/or rudimentary fingers (knob-like fingers)"	comment:homomint|comment:mint|figure legend:T3 T2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:1.3x10^-9(molar)	2009/09/23	2014/10/16	rogid:1+H+MmShXRpzq5qIDid7rv8ApMk9606	rogid:4R1OzI0j8xrONBb1/IXp8MOsaLc9606	intact-crc:FC5157F5A95A49A3|rigid:ZwwaoOLCVU9mHAMPacKVxMXmW0M	false	-	mutation disrupting interaction:66-66(MINT-7264558)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P43026	uniprotkb:O00238	intact:EBI-8571476|ensembl:ENSP00000363489|ensembl:ENSP00000363492|uniprotkb:Q96SB1|intact:MINT-7264433|uniprotkb:E1P5Q2	intact:EBI-7527193|uniprotkb:P78366|uniprotkb:B2R953|uniprotkb:B4DSV1|intact:MINT-1340235|ensembl:ENSP00000264568|ensembl:ENSP00000378389|ensembl:ENSP00000421671|ensembl:ENSP00000425444|ensembl:ENSP00000426617|ensembl:ENSP00000500035	psi-mi:gdf5_human(display_long)|uniprotkb:GDF5(gene name)|psi-mi:GDF5(display_short)|uniprotkb:CDMP1(gene name synonym)|uniprotkb:Cartilage-derived morphogenetic protein 1(gene name synonym)|uniprotkb:Radotermin(gene name synonym)|uniprotkb:BMP14(gene name synonym)|uniprotkb:Bone morphogenetic protein 14(gene name synonym)|uniprotkb:Lipopolysaccharide-associated protein 4(gene name synonym)	psi-mi:bmr1b_human(display_long)|uniprotkb:BMPR1B(gene name)|psi-mi:BMPR1B(display_short)	psi-mi:"MI:0107"(surface plasmon resonance)	Kotzsch et al. (2009)	mint:MINT-7263386|pubmed:19229295|imex:IM-14029|doi:10.1038/emboj.2009.37	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8571546|mint:MINT-7264483|imex:IM-14029-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001306067.1|ensembl:ENSG00000125965(gene)|ensembl:ENST00000374369(transcript)|ensembl:ENST00000374372(transcript)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008083"(growth factor activity)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0032332"(positive regulation of chondrocyte differentiation)|go:"GO:0035136"(forelimb morphogenesis)|go:"GO:0035137"(hindlimb morphogenesis)|go:"GO:0036122"(BMP binding)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043932"(ossification involved in bone remodeling)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0060390"(regulation of SMAD protein signal transduction)|go:"GO:0060395"(SMAD protein signal transduction)|interpro:IPR001839(Transforming growth factor beta)|interpro:IPR015615(Transforming growth factor-beta-related)|interpro:IPR017948|interpro:IPR029034|mint:P43026|rcsb pdb:1WAQ|rcsb pdb:2BHK|rcsb pdb:3EVS|rcsb pdb:3QB4|rcsb pdb:5HK5|rcsb pdb:6Z3G|rcsb pdb:6Z3H|go:"GO:0060591"(chondroblast differentiation)|go:"GO:2001054"(negative regulation of mesenchymal cell apoptotic process)|interpro:IPR001111("Transforming growth factor beta (TGFb), N-terminal")|rcsb pdb:6Z3J|rcsb pdb:6Z3L|rcsb pdb:6Z3M|reactome:R-HSA-2129379|refseq:NP_000548.2|dip:DIP-5823N|refseq:XP_011527377.1|mint:MINT-7264488(identity)	refseq:XP_011530503.1|refseq:NP_001194.1|refseq:NP_001243721.1|refseq:NP_001243722.1|refseq:NP_001243723.1|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0060350"(endochondral bone morphogenesis)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0098821"(BMP receptor activity)|go:"GO:0140537"(transcription regulator activator activity)|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1902731"(negative regulation of chondrocyte proliferation)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:1990712"(HFE-transferrin receptor complex)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003605(TGF beta receptor, GS motif)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:O00238|rcsb pdb:3MDY|reactome:R-HSA-201451|refseq:XP_016864047.1|refseq:XP_016864048.1|refseq:XP_016864049.1|refseq:XP_016864050.1|ensembl:ENSG00000138696(gene)|ensembl:ENST00000264568(transcript)|ensembl:ENST00000394931(transcript)|ensembl:ENST00000509540(transcript)|ensembl:ENST00000512312(transcript)|ensembl:ENST00000515059(transcript)|ensembl:ENST00000672698(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001502"(cartilage condensation)|go:"GO:0001550"(ovarian cumulus expansion)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001654"(eye development)|go:"GO:0002063"(chondrocyte development)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004675"(transmembrane receptor protein serine/threonine kinase activity)|go:"GO:0005025"(transforming growth factor beta receptor activity, type I)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0019211"(phosphatase activator activity)|go:"GO:0030166"(proteoglycan biosynthetic process)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0031290"(retinal ganglion cell axon guidance)|go:"GO:0032332"(positive regulation of chondrocyte differentiation)|go:"GO:0035108"(limb morphogenesis)|go:"GO:0036122"(BMP binding)|go:"GO:0042698"(ovulation cycle)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043235"(receptor complex)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|mint:MINT-7264486(identity)	-	comment:mint	function:"Defects in BMPR1B are a cause of brachydactyly type A2 (BDA2) [MIM:112600]. Brachydactylies (BDs) are a group of inherited malformations characterized by shortening of the digits due to abnormal development of the phalanges and/or the metacarpals. They have been classified on an anatomic and genetic basis into five groups, A to E, including three subgroups (A1 to A3) that usually manifest as autosomal dominant traits. BDA2 was described first in a large Norwegian kindred. BDA2 is caused by mutations in BMPR1B gene and studies demonstrate that these mutations function as dominant negatives in vitro and in vivo"|function:On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMPS/OP-1|comment:mint|function:"Defects in BMPR1B are the cause of acromesomelic chondrodysplasia with genital anomalies [MIM:609441]. Acromesomelic chondrodysplasias are rare hereditary skeletal disorders characterized by short stature, very short limbs, and hand/foot malformations. The severity of limb abnormalities increases from proximal to distal with profoundly affected hands and feet showing brachydactyly and/or rudimentary fingers (knob-like fingers)"	figure legend:T3|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:7.0x10^-10(molar)	2009/09/23	2014/10/16	rogid:1+H+MmShXRpzq5qIDid7rv8ApMk9606	rogid:4R1OzI0j8xrONBb1/IXp8MOsaLc9606	intact-crc:AA376175E062CAAB|rigid:ZwwaoOLCVU9mHAMPacKVxMXmW0M	false	mutation increasing interaction:57-57(MINT-7264491)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P43026	uniprotkb:O00238	intact:EBI-8571476|ensembl:ENSP00000363489|ensembl:ENSP00000363492|uniprotkb:Q96SB1|intact:MINT-7264433|uniprotkb:E1P5Q2	intact:EBI-7527193|uniprotkb:P78366|uniprotkb:B2R953|uniprotkb:B4DSV1|intact:MINT-1340235|ensembl:ENSP00000264568|ensembl:ENSP00000378389|ensembl:ENSP00000421671|ensembl:ENSP00000425444|ensembl:ENSP00000426617|ensembl:ENSP00000500035	psi-mi:gdf5_human(display_long)|uniprotkb:GDF5(gene name)|psi-mi:GDF5(display_short)|uniprotkb:CDMP1(gene name synonym)|uniprotkb:Cartilage-derived morphogenetic protein 1(gene name synonym)|uniprotkb:Radotermin(gene name synonym)|uniprotkb:BMP14(gene name synonym)|uniprotkb:Bone morphogenetic protein 14(gene name synonym)|uniprotkb:Lipopolysaccharide-associated protein 4(gene name synonym)	psi-mi:bmr1b_human(display_long)|uniprotkb:BMPR1B(gene name)|psi-mi:BMPR1B(display_short)	psi-mi:"MI:0107"(surface plasmon resonance)	Kotzsch et al. (2009)	mint:MINT-7263386|pubmed:19229295|imex:IM-14029|doi:10.1038/emboj.2009.37	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8571563|mint:MINT-7264510|imex:IM-14029-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001306067.1|ensembl:ENSG00000125965(gene)|ensembl:ENST00000374369(transcript)|ensembl:ENST00000374372(transcript)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008083"(growth factor activity)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0032332"(positive regulation of chondrocyte differentiation)|go:"GO:0035136"(forelimb morphogenesis)|go:"GO:0035137"(hindlimb morphogenesis)|go:"GO:0036122"(BMP binding)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043932"(ossification involved in bone remodeling)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0060390"(regulation of SMAD protein signal transduction)|go:"GO:0060395"(SMAD protein signal transduction)|interpro:IPR001839(Transforming growth factor beta)|interpro:IPR015615(Transforming growth factor-beta-related)|interpro:IPR017948|interpro:IPR029034|mint:P43026|rcsb pdb:1WAQ|rcsb pdb:2BHK|rcsb pdb:3EVS|rcsb pdb:3QB4|rcsb pdb:5HK5|rcsb pdb:6Z3G|rcsb pdb:6Z3H|go:"GO:0060591"(chondroblast differentiation)|go:"GO:2001054"(negative regulation of mesenchymal cell apoptotic process)|interpro:IPR001111("Transforming growth factor beta (TGFb), N-terminal")|rcsb pdb:6Z3J|rcsb pdb:6Z3L|rcsb pdb:6Z3M|reactome:R-HSA-2129379|refseq:NP_000548.2|dip:DIP-5823N|refseq:XP_011527377.1|mint:MINT-7264515(identity)	refseq:XP_011530503.1|refseq:NP_001194.1|refseq:NP_001243721.1|refseq:NP_001243722.1|refseq:NP_001243723.1|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0060350"(endochondral bone morphogenesis)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0098821"(BMP receptor activity)|go:"GO:0140537"(transcription regulator activator activity)|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1902731"(negative regulation of chondrocyte proliferation)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:1990712"(HFE-transferrin receptor complex)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003605(TGF beta receptor, GS motif)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:O00238|rcsb pdb:3MDY|reactome:R-HSA-201451|refseq:XP_016864047.1|refseq:XP_016864048.1|refseq:XP_016864049.1|refseq:XP_016864050.1|ensembl:ENSG00000138696(gene)|ensembl:ENST00000264568(transcript)|ensembl:ENST00000394931(transcript)|ensembl:ENST00000509540(transcript)|ensembl:ENST00000512312(transcript)|ensembl:ENST00000515059(transcript)|ensembl:ENST00000672698(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001502"(cartilage condensation)|go:"GO:0001550"(ovarian cumulus expansion)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001654"(eye development)|go:"GO:0002063"(chondrocyte development)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004675"(transmembrane receptor protein serine/threonine kinase activity)|go:"GO:0005025"(transforming growth factor beta receptor activity, type I)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0019211"(phosphatase activator activity)|go:"GO:0030166"(proteoglycan biosynthetic process)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0031290"(retinal ganglion cell axon guidance)|go:"GO:0032332"(positive regulation of chondrocyte differentiation)|go:"GO:0035108"(limb morphogenesis)|go:"GO:0036122"(BMP binding)|go:"GO:0042698"(ovulation cycle)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043235"(receptor complex)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|mint:MINT-7264513(identity)	-	comment:mint	function:"Defects in BMPR1B are a cause of brachydactyly type A2 (BDA2) [MIM:112600]. Brachydactylies (BDs) are a group of inherited malformations characterized by shortening of the digits due to abnormal development of the phalanges and/or the metacarpals. They have been classified on an anatomic and genetic basis into five groups, A to E, including three subgroups (A1 to A3) that usually manifest as autosomal dominant traits. BDA2 was described first in a large Norwegian kindred. BDA2 is caused by mutations in BMPR1B gene and studies demonstrate that these mutations function as dominant negatives in vitro and in vivo"|function:On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMPS/OP-1|comment:mint|function:"Defects in BMPR1B are the cause of acromesomelic chondrodysplasia with genital anomalies [MIM:609441]. Acromesomelic chondrodysplasias are rare hereditary skeletal disorders characterized by short stature, very short limbs, and hand/foot malformations. The severity of limb abnormalities increases from proximal to distal with profoundly affected hands and feet showing brachydactyly and/or rudimentary fingers (knob-like fingers)"	figure legend:T3|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:4.23x10^-8(molar)	2009/09/23	2014/10/16	rogid:1+H+MmShXRpzq5qIDid7rv8ApMk9606	rogid:4R1OzI0j8xrONBb1/IXp8MOsaLc9606	intact-crc:B4D0067FE357FF97|rigid:ZwwaoOLCVU9mHAMPacKVxMXmW0M	false	mutation decreasing interaction:60-60(MINT-7264516)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O00238	uniprotkb:P43026	intact:EBI-7527193|uniprotkb:P78366|uniprotkb:B2R953|uniprotkb:B4DSV1|intact:MINT-1340235|ensembl:ENSP00000264568|ensembl:ENSP00000378389|ensembl:ENSP00000421671|ensembl:ENSP00000425444|ensembl:ENSP00000426617|ensembl:ENSP00000500035	intact:EBI-8571476|ensembl:ENSP00000363489|ensembl:ENSP00000363492|uniprotkb:Q96SB1|intact:MINT-7264433|uniprotkb:E1P5Q2	psi-mi:bmr1b_human(display_long)|uniprotkb:BMPR1B(gene name)|psi-mi:BMPR1B(display_short)	psi-mi:gdf5_human(display_long)|uniprotkb:GDF5(gene name)|psi-mi:GDF5(display_short)|uniprotkb:CDMP1(gene name synonym)|uniprotkb:Cartilage-derived morphogenetic protein 1(gene name synonym)|uniprotkb:Radotermin(gene name synonym)|uniprotkb:BMP14(gene name synonym)|uniprotkb:Bone morphogenetic protein 14(gene name synonym)|uniprotkb:Lipopolysaccharide-associated protein 4(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Kotzsch et al. (2009)	mint:MINT-7263386|pubmed:19229295|imex:IM-14029|doi:10.1038/emboj.2009.37	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8571588|mint:MINT-7264524|imex:IM-14029-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011530503.1|refseq:NP_001194.1|refseq:NP_001243721.1|refseq:NP_001243722.1|refseq:NP_001243723.1|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0060350"(endochondral bone morphogenesis)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0098821"(BMP receptor activity)|go:"GO:0140537"(transcription regulator activator activity)|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1902731"(negative regulation of chondrocyte proliferation)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:1990712"(HFE-transferrin receptor complex)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003605(TGF beta receptor, GS motif)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:O00238|rcsb pdb:3MDY|reactome:R-HSA-201451|refseq:XP_016864047.1|refseq:XP_016864048.1|refseq:XP_016864049.1|refseq:XP_016864050.1|ensembl:ENSG00000138696(gene)|ensembl:ENST00000264568(transcript)|ensembl:ENST00000394931(transcript)|ensembl:ENST00000509540(transcript)|ensembl:ENST00000512312(transcript)|ensembl:ENST00000515059(transcript)|ensembl:ENST00000672698(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001502"(cartilage condensation)|go:"GO:0001550"(ovarian cumulus expansion)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001654"(eye development)|go:"GO:0002063"(chondrocyte development)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004675"(transmembrane receptor protein serine/threonine kinase activity)|go:"GO:0005025"(transforming growth factor beta receptor activity, type I)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0019211"(phosphatase activator activity)|go:"GO:0030166"(proteoglycan biosynthetic process)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0031290"(retinal ganglion cell axon guidance)|go:"GO:0032332"(positive regulation of chondrocyte differentiation)|go:"GO:0035108"(limb morphogenesis)|go:"GO:0036122"(BMP binding)|go:"GO:0042698"(ovulation cycle)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043235"(receptor complex)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|mint:MINT-7264531(identity)	refseq:NP_001306067.1|ensembl:ENSG00000125965(gene)|ensembl:ENST00000374369(transcript)|ensembl:ENST00000374372(transcript)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008083"(growth factor activity)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0032332"(positive regulation of chondrocyte differentiation)|go:"GO:0035136"(forelimb morphogenesis)|go:"GO:0035137"(hindlimb morphogenesis)|go:"GO:0036122"(BMP binding)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043932"(ossification involved in bone remodeling)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0060390"(regulation of SMAD protein signal transduction)|go:"GO:0060395"(SMAD protein signal transduction)|interpro:IPR001839(Transforming growth factor beta)|interpro:IPR015615(Transforming growth factor-beta-related)|interpro:IPR017948|interpro:IPR029034|mint:P43026|rcsb pdb:1WAQ|rcsb pdb:2BHK|rcsb pdb:3EVS|rcsb pdb:3QB4|rcsb pdb:5HK5|rcsb pdb:6Z3G|rcsb pdb:6Z3H|go:"GO:0060591"(chondroblast differentiation)|go:"GO:2001054"(negative regulation of mesenchymal cell apoptotic process)|interpro:IPR001111("Transforming growth factor beta (TGFb), N-terminal")|rcsb pdb:6Z3J|rcsb pdb:6Z3L|rcsb pdb:6Z3M|reactome:R-HSA-2129379|refseq:NP_000548.2|dip:DIP-5823N|refseq:XP_011527377.1|mint:MINT-7264527(identity)	-	function:"Defects in BMPR1B are a cause of brachydactyly type A2 (BDA2) [MIM:112600]. Brachydactylies (BDs) are a group of inherited malformations characterized by shortening of the digits due to abnormal development of the phalanges and/or the metacarpals. They have been classified on an anatomic and genetic basis into five groups, A to E, including three subgroups (A1 to A3) that usually manifest as autosomal dominant traits. BDA2 was described first in a large Norwegian kindred. BDA2 is caused by mutations in BMPR1B gene and studies demonstrate that these mutations function as dominant negatives in vitro and in vivo"|function:On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMPS/OP-1|comment:mint|function:"Defects in BMPR1B are the cause of acromesomelic chondrodysplasia with genital anomalies [MIM:609441]. Acromesomelic chondrodysplasias are rare hereditary skeletal disorders characterized by short stature, very short limbs, and hand/foot malformations. The severity of limb abnormalities increases from proximal to distal with profoundly affected hands and feet showing brachydactyly and/or rudimentary fingers (knob-like fingers)"	comment:mint	comment:homomint|comment:mint|figure legend:T2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:8.2x10^-9(molar)	2009/09/23	2014/10/16	rogid:4R1OzI0j8xrONBb1/IXp8MOsaLc9606	rogid:1+H+MmShXRpzq5qIDid7rv8ApMk9606	intact-crc:E83D87D7F08CB79B|rigid:ZwwaoOLCVU9mHAMPacKVxMXmW0M	false	mutation decreasing interaction:67-67(MINT-7264536)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O00238	uniprotkb:P12643	intact:EBI-7527193|uniprotkb:P78366|uniprotkb:B2R953|uniprotkb:B4DSV1|intact:MINT-1340235|ensembl:ENSP00000264568|ensembl:ENSP00000378389|ensembl:ENSP00000421671|ensembl:ENSP00000425444|ensembl:ENSP00000426617|ensembl:ENSP00000500035	intact:EBI-1029262|ensembl:ENSP00000368104	psi-mi:bmr1b_human(display_long)|uniprotkb:BMPR1B(gene name)|psi-mi:BMPR1B(display_short)	psi-mi:bmp2_human(display_long)|uniprotkb:BMP2(gene name)|psi-mi:BMP2(display_short)|uniprotkb:BMP2A(gene name synonym)|uniprotkb:Bone morphogenetic protein 2A(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Kotzsch et al. (2009)	mint:MINT-7263386|pubmed:19229295|imex:IM-14029|doi:10.1038/emboj.2009.37	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8571731|mint:MINT-7264562|imex:IM-14029-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011530503.1|refseq:NP_001194.1|refseq:NP_001243721.1|refseq:NP_001243722.1|refseq:NP_001243723.1|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0060350"(endochondral bone morphogenesis)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0098821"(BMP receptor activity)|go:"GO:0140537"(transcription regulator activator activity)|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1902731"(negative regulation of chondrocyte proliferation)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:1990712"(HFE-transferrin receptor complex)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003605(TGF beta receptor, GS motif)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:O00238|rcsb pdb:3MDY|reactome:R-HSA-201451|refseq:XP_016864047.1|refseq:XP_016864048.1|refseq:XP_016864049.1|refseq:XP_016864050.1|ensembl:ENSG00000138696(gene)|ensembl:ENST00000264568(transcript)|ensembl:ENST00000394931(transcript)|ensembl:ENST00000509540(transcript)|ensembl:ENST00000512312(transcript)|ensembl:ENST00000515059(transcript)|ensembl:ENST00000672698(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001502"(cartilage condensation)|go:"GO:0001550"(ovarian cumulus expansion)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001654"(eye development)|go:"GO:0002063"(chondrocyte development)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004675"(transmembrane receptor protein serine/threonine kinase activity)|go:"GO:0005025"(transforming growth factor beta receptor activity, type I)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0019211"(phosphatase activator activity)|go:"GO:0030166"(proteoglycan biosynthetic process)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0031290"(retinal ganglion cell axon guidance)|go:"GO:0032332"(positive regulation of chondrocyte differentiation)|go:"GO:0035108"(limb morphogenesis)|go:"GO:0036122"(BMP binding)|go:"GO:0042698"(ovulation cycle)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043235"(receptor complex)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|mint:MINT-7264565(identity)	refseq:NP_001191.1|ensembl:ENSG00000125845(gene)|ensembl:ENST00000378827(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001501"(skeletal system development)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0003130"(BMP signaling pathway involved in heart induction)|go:"GO:0003176"(aortic valve development)|go:"GO:0003181"(atrioventricular valve morphogenesis)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003210"(cardiac atrium formation)|go:"GO:0003272"(endocardial cushion formation)|go:"GO:0003308"(negative regulation of Wnt signaling pathway involved in heart development)|go:"GO:0003331"(positive regulation of extracellular matrix constituent secretion)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006029"(proteoglycan metabolic process)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007507"(heart development)|go:"GO:0008083"(growth factor activity)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009617"(response to bacterium)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0010894"(negative regulation of steroid biosynthetic process)|go:"GO:0010922"(positive regulation of phosphatase activity)|go:"GO:0019211"(phosphatase activator activity)|go:"GO:0021537"(telencephalon development)|go:"GO:0021978"(telencephalon regionalization)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0030282"(bone mineralization)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031648"(protein destabilization)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032348"(negative regulation of aldosterone biosynthetic process)|go:"GO:0033690"(positive regulation of osteoblast proliferation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:0035051"(cardiocyte differentiation)|go:"GO:1905072"(cardiac jelly development)|go:"GO:0035054"(embryonic heart tube anterior/posterior pattern specification)|go:"GO:0035360"(positive regulation of peroxisome proliferator activated receptor signaling pathway)|go:"GO:1905222"(atrioventricular canal morphogenesis)|go:"GO:0035630"(bone mineralization involved in bone maturation)|go:"GO:0039706"(co-receptor binding)|go:"GO:2000065"(negative regulation of cortisol biosynthetic process)|go:"GO:2000726"(negative regulation of cardiac muscle cell differentiation)|interpro:IPR001111("Transforming growth factor beta (TGFb), N-terminal")|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042482"(positive regulation of odontogenesis)|interpro:IPR001839(Transforming growth factor beta)|interpro:IPR015615(Transforming growth factor-beta-related)|go:"GO:0042487"(regulation of odontogenesis of dentin-containing tooth)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR017948|go:"GO:0043407"(negative regulation of MAP kinase activity)|interpro:IPR029034|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0043569"(negative regulation of insulin-like growth factor receptor signaling pathway)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045778"(positive regulation of ossification)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0048711"(positive regulation of astrocyte differentiation)|go:"GO:0048762"(mesenchymal cell differentiation)|go:"GO:0048839"(inner ear development)|go:"GO:0051042"(negative regulation of calcium-independent cell-cell adhesion)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0055008"(cardiac muscle tissue morphogenesis)|go:"GO:0060039"(pericardium development)|go:"GO:0060128"(corticotropin hormone secreting cell differentiation)|go:"GO:0060129"(thyroid-stimulating hormone-secreting cell differentiation)|go:"GO:0060317"(cardiac epithelial to mesenchymal transition)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0060485"(mesenchyme development)|go:"GO:0060804"(positive regulation of Wnt signaling pathway by BMP signaling pathway)|mint:P12643|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0061312"(BMP signaling pathway involved in heart development)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070700"(BMP receptor binding)|go:"GO:0070724"(BMP receptor complex)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0072138"(mesenchymal cell proliferation involved in ureteric bud development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0140537"(transcription regulator activator activity)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|rcsb pdb:1ES7|rcsb pdb:1REU|rcsb pdb:1REW|rcsb pdb:2GOO|rcsb pdb:2H62|rcsb pdb:2H64|rcsb pdb:2QJ9|rcsb pdb:2QJA|rcsb pdb:2QJB|rcsb pdb:3BK3|rcsb pdb:3BMP|rcsb pdb:4MID|rcsb pdb:4N1D|rcsb pdb:4UHY|rcsb pdb:4UHZ|rcsb pdb:4UI0|rcsb pdb:4UI1|rcsb pdb:4UI2|rcsb pdb:6OMN|reactome:R-HSA-201451|reactome:R-HSA-2129379|reactome:R-HSA-8878166|reactome:R-HSA-8939902|dip:DIP-5792N|mint:MINT-7264569(identity)	-	function:"Defects in BMPR1B are a cause of brachydactyly type A2 (BDA2) [MIM:112600]. Brachydactylies (BDs) are a group of inherited malformations characterized by shortening of the digits due to abnormal development of the phalanges and/or the metacarpals. They have been classified on an anatomic and genetic basis into five groups, A to E, including three subgroups (A1 to A3) that usually manifest as autosomal dominant traits. BDA2 was described first in a large Norwegian kindred. BDA2 is caused by mutations in BMPR1B gene and studies demonstrate that these mutations function as dominant negatives in vitro and in vivo"|function:On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMPS/OP-1|comment:mint|function:"Defects in BMPR1B are the cause of acromesomelic chondrodysplasia with genital anomalies [MIM:609441]. Acromesomelic chondrodysplasias are rare hereditary skeletal disorders characterized by short stature, very short limbs, and hand/foot malformations. The severity of limb abnormalities increases from proximal to distal with profoundly affected hands and feet showing brachydactyly and/or rudimentary fingers (knob-like fingers)"	-	comment:homomint|comment:mint|figure legend:T2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:4.8x10^-9(molar)	2009/09/23	2014/10/16	rogid:4R1OzI0j8xrONBb1/IXp8MOsaLc9606	rogid:XuFrOBMwPSqof5Lwo7v6IyzNWX09606	intact-crc:C9FF070D85F99354|rigid:b2kcBr/GIj6qiIKrroWvHpkDOGo	false	mutation disrupting interaction:66-66(MINT-7264566)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P43026	uniprotkb:O00238	intact:EBI-8571476|ensembl:ENSP00000363489|ensembl:ENSP00000363492|uniprotkb:Q96SB1|intact:MINT-7264433|uniprotkb:E1P5Q2	intact:EBI-7527193|uniprotkb:P78366|uniprotkb:B2R953|uniprotkb:B4DSV1|intact:MINT-1340235|ensembl:ENSP00000264568|ensembl:ENSP00000378389|ensembl:ENSP00000421671|ensembl:ENSP00000425444|ensembl:ENSP00000426617|ensembl:ENSP00000500035	psi-mi:gdf5_human(display_long)|uniprotkb:GDF5(gene name)|psi-mi:GDF5(display_short)|uniprotkb:CDMP1(gene name synonym)|uniprotkb:Cartilage-derived morphogenetic protein 1(gene name synonym)|uniprotkb:Radotermin(gene name synonym)|uniprotkb:BMP14(gene name synonym)|uniprotkb:Bone morphogenetic protein 14(gene name synonym)|uniprotkb:Lipopolysaccharide-associated protein 4(gene name synonym)	psi-mi:bmr1b_human(display_long)|uniprotkb:BMPR1B(gene name)|psi-mi:BMPR1B(display_short)	psi-mi:"MI:0107"(surface plasmon resonance)	Kotzsch et al. (2009)	mint:MINT-7263386|pubmed:19229295|imex:IM-14029|doi:10.1038/emboj.2009.37	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8571663|mint:MINT-7264542|imex:IM-14029-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001306067.1|ensembl:ENSG00000125965(gene)|ensembl:ENST00000374369(transcript)|ensembl:ENST00000374372(transcript)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008083"(growth factor activity)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0032332"(positive regulation of chondrocyte differentiation)|go:"GO:0035136"(forelimb morphogenesis)|go:"GO:0035137"(hindlimb morphogenesis)|go:"GO:0036122"(BMP binding)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043932"(ossification involved in bone remodeling)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0060390"(regulation of SMAD protein signal transduction)|go:"GO:0060395"(SMAD protein signal transduction)|interpro:IPR001839(Transforming growth factor beta)|interpro:IPR015615(Transforming growth factor-beta-related)|interpro:IPR017948|interpro:IPR029034|mint:P43026|rcsb pdb:1WAQ|rcsb pdb:2BHK|rcsb pdb:3EVS|rcsb pdb:3QB4|rcsb pdb:5HK5|rcsb pdb:6Z3G|rcsb pdb:6Z3H|go:"GO:0060591"(chondroblast differentiation)|go:"GO:2001054"(negative regulation of mesenchymal cell apoptotic process)|interpro:IPR001111("Transforming growth factor beta (TGFb), N-terminal")|rcsb pdb:6Z3J|rcsb pdb:6Z3L|rcsb pdb:6Z3M|reactome:R-HSA-2129379|refseq:NP_000548.2|dip:DIP-5823N|refseq:XP_011527377.1|mint:MINT-7264549(identity)	refseq:XP_011530503.1|refseq:NP_001194.1|refseq:NP_001243721.1|refseq:NP_001243722.1|refseq:NP_001243723.1|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0060350"(endochondral bone morphogenesis)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0098821"(BMP receptor activity)|go:"GO:0140537"(transcription regulator activator activity)|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1902731"(negative regulation of chondrocyte proliferation)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:1990712"(HFE-transferrin receptor complex)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003605(TGF beta receptor, GS motif)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:O00238|rcsb pdb:3MDY|reactome:R-HSA-201451|refseq:XP_016864047.1|refseq:XP_016864048.1|refseq:XP_016864049.1|refseq:XP_016864050.1|ensembl:ENSG00000138696(gene)|ensembl:ENST00000264568(transcript)|ensembl:ENST00000394931(transcript)|ensembl:ENST00000509540(transcript)|ensembl:ENST00000512312(transcript)|ensembl:ENST00000515059(transcript)|ensembl:ENST00000672698(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001502"(cartilage condensation)|go:"GO:0001550"(ovarian cumulus expansion)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001654"(eye development)|go:"GO:0002063"(chondrocyte development)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004675"(transmembrane receptor protein serine/threonine kinase activity)|go:"GO:0005025"(transforming growth factor beta receptor activity, type I)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0019211"(phosphatase activator activity)|go:"GO:0030166"(proteoglycan biosynthetic process)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0031290"(retinal ganglion cell axon guidance)|go:"GO:0032332"(positive regulation of chondrocyte differentiation)|go:"GO:0035108"(limb morphogenesis)|go:"GO:0036122"(BMP binding)|go:"GO:0042698"(ovulation cycle)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043235"(receptor complex)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|mint:MINT-7264545(identity)	-	comment:mint	function:"Defects in BMPR1B are a cause of brachydactyly type A2 (BDA2) [MIM:112600]. Brachydactylies (BDs) are a group of inherited malformations characterized by shortening of the digits due to abnormal development of the phalanges and/or the metacarpals. They have been classified on an anatomic and genetic basis into five groups, A to E, including three subgroups (A1 to A3) that usually manifest as autosomal dominant traits. BDA2 was described first in a large Norwegian kindred. BDA2 is caused by mutations in BMPR1B gene and studies demonstrate that these mutations function as dominant negatives in vitro and in vivo"|function:On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMPS/OP-1|comment:mint|function:"Defects in BMPR1B are the cause of acromesomelic chondrodysplasia with genital anomalies [MIM:609441]. Acromesomelic chondrodysplasias are rare hereditary skeletal disorders characterized by short stature, very short limbs, and hand/foot malformations. The severity of limb abnormalities increases from proximal to distal with profoundly affected hands and feet showing brachydactyly and/or rudimentary fingers (knob-like fingers)"	comment:homomint|comment:mint|figure legend:T2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:4.1x10^-9(molar)	2009/09/23	2014/10/16	rogid:1+H+MmShXRpzq5qIDid7rv8ApMk9606	rogid:4R1OzI0j8xrONBb1/IXp8MOsaLc9606	intact-crc:064B4C813CFA8048|rigid:ZwwaoOLCVU9mHAMPacKVxMXmW0M	false	-	mutation decreasing interaction:22-22(MINT-7264546)|mutation decreasing interaction:23-23(MINT-7264553)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O00238	uniprotkb:P12643	intact:EBI-7527193|uniprotkb:P78366|uniprotkb:B2R953|uniprotkb:B4DSV1|intact:MINT-1340235|ensembl:ENSP00000264568|ensembl:ENSP00000378389|ensembl:ENSP00000421671|ensembl:ENSP00000425444|ensembl:ENSP00000426617|ensembl:ENSP00000500035	intact:EBI-1029262|ensembl:ENSP00000368104	psi-mi:bmr1b_human(display_long)|uniprotkb:BMPR1B(gene name)|psi-mi:BMPR1B(display_short)	psi-mi:bmp2_human(display_long)|uniprotkb:BMP2(gene name)|psi-mi:BMP2(display_short)|uniprotkb:BMP2A(gene name synonym)|uniprotkb:Bone morphogenetic protein 2A(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Kotzsch et al. (2009)	mint:MINT-7263386|pubmed:19229295|imex:IM-14029|doi:10.1038/emboj.2009.37	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8571822|mint:MINT-7264587|imex:IM-14029-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011530503.1|refseq:NP_001194.1|refseq:NP_001243721.1|refseq:NP_001243722.1|refseq:NP_001243723.1|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0060350"(endochondral bone morphogenesis)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0098821"(BMP receptor activity)|go:"GO:0140537"(transcription regulator activator activity)|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1902731"(negative regulation of chondrocyte proliferation)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:1990712"(HFE-transferrin receptor complex)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003605(TGF beta receptor, GS motif)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:O00238|rcsb pdb:3MDY|reactome:R-HSA-201451|refseq:XP_016864047.1|refseq:XP_016864048.1|refseq:XP_016864049.1|refseq:XP_016864050.1|ensembl:ENSG00000138696(gene)|ensembl:ENST00000264568(transcript)|ensembl:ENST00000394931(transcript)|ensembl:ENST00000509540(transcript)|ensembl:ENST00000512312(transcript)|ensembl:ENST00000515059(transcript)|ensembl:ENST00000672698(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001502"(cartilage condensation)|go:"GO:0001550"(ovarian cumulus expansion)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001654"(eye development)|go:"GO:0002063"(chondrocyte development)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004675"(transmembrane receptor protein serine/threonine kinase activity)|go:"GO:0005025"(transforming growth factor beta receptor activity, type I)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0019211"(phosphatase activator activity)|go:"GO:0030166"(proteoglycan biosynthetic process)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0031290"(retinal ganglion cell axon guidance)|go:"GO:0032332"(positive regulation of chondrocyte differentiation)|go:"GO:0035108"(limb morphogenesis)|go:"GO:0036122"(BMP binding)|go:"GO:0042698"(ovulation cycle)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043235"(receptor complex)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|mint:MINT-7264590(identity)	refseq:NP_001191.1|ensembl:ENSG00000125845(gene)|ensembl:ENST00000378827(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001501"(skeletal system development)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0003130"(BMP signaling pathway involved in heart induction)|go:"GO:0003176"(aortic valve development)|go:"GO:0003181"(atrioventricular valve morphogenesis)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003210"(cardiac atrium formation)|go:"GO:0003272"(endocardial cushion formation)|go:"GO:0003308"(negative regulation of Wnt signaling pathway involved in heart development)|go:"GO:0003331"(positive regulation of extracellular matrix constituent secretion)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006029"(proteoglycan metabolic process)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007507"(heart development)|go:"GO:0008083"(growth factor activity)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009617"(response to bacterium)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0010894"(negative regulation of steroid biosynthetic process)|go:"GO:0010922"(positive regulation of phosphatase activity)|go:"GO:0019211"(phosphatase activator activity)|go:"GO:0021537"(telencephalon development)|go:"GO:0021978"(telencephalon regionalization)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0030282"(bone mineralization)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031648"(protein destabilization)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032348"(negative regulation of aldosterone biosynthetic process)|go:"GO:0033690"(positive regulation of osteoblast proliferation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:0035051"(cardiocyte differentiation)|go:"GO:1905072"(cardiac jelly development)|go:"GO:0035054"(embryonic heart tube anterior/posterior pattern specification)|go:"GO:0035360"(positive regulation of peroxisome proliferator activated receptor signaling pathway)|go:"GO:1905222"(atrioventricular canal morphogenesis)|go:"GO:0035630"(bone mineralization involved in bone maturation)|go:"GO:0039706"(co-receptor binding)|go:"GO:2000065"(negative regulation of cortisol biosynthetic process)|go:"GO:2000726"(negative regulation of cardiac muscle cell differentiation)|interpro:IPR001111("Transforming growth factor beta (TGFb), N-terminal")|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042482"(positive regulation of odontogenesis)|interpro:IPR001839(Transforming growth factor beta)|interpro:IPR015615(Transforming growth factor-beta-related)|go:"GO:0042487"(regulation of odontogenesis of dentin-containing tooth)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR017948|go:"GO:0043407"(negative regulation of MAP kinase activity)|interpro:IPR029034|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0043569"(negative regulation of insulin-like growth factor receptor signaling pathway)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045778"(positive regulation of ossification)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0048711"(positive regulation of astrocyte differentiation)|go:"GO:0048762"(mesenchymal cell differentiation)|go:"GO:0048839"(inner ear development)|go:"GO:0051042"(negative regulation of calcium-independent cell-cell adhesion)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0055008"(cardiac muscle tissue morphogenesis)|go:"GO:0060039"(pericardium development)|go:"GO:0060128"(corticotropin hormone secreting cell differentiation)|go:"GO:0060129"(thyroid-stimulating hormone-secreting cell differentiation)|go:"GO:0060317"(cardiac epithelial to mesenchymal transition)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0060485"(mesenchyme development)|go:"GO:0060804"(positive regulation of Wnt signaling pathway by BMP signaling pathway)|mint:P12643|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0061312"(BMP signaling pathway involved in heart development)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070700"(BMP receptor binding)|go:"GO:0070724"(BMP receptor complex)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0072138"(mesenchymal cell proliferation involved in ureteric bud development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0140537"(transcription regulator activator activity)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|rcsb pdb:1ES7|rcsb pdb:1REU|rcsb pdb:1REW|rcsb pdb:2GOO|rcsb pdb:2H62|rcsb pdb:2H64|rcsb pdb:2QJ9|rcsb pdb:2QJA|rcsb pdb:2QJB|rcsb pdb:3BK3|rcsb pdb:3BMP|rcsb pdb:4MID|rcsb pdb:4N1D|rcsb pdb:4UHY|rcsb pdb:4UHZ|rcsb pdb:4UI0|rcsb pdb:4UI1|rcsb pdb:4UI2|rcsb pdb:6OMN|reactome:R-HSA-201451|reactome:R-HSA-2129379|reactome:R-HSA-8878166|reactome:R-HSA-8939902|dip:DIP-5792N|mint:MINT-7264594(identity)	-	function:"Defects in BMPR1B are a cause of brachydactyly type A2 (BDA2) [MIM:112600]. Brachydactylies (BDs) are a group of inherited malformations characterized by shortening of the digits due to abnormal development of the phalanges and/or the metacarpals. They have been classified on an anatomic and genetic basis into five groups, A to E, including three subgroups (A1 to A3) that usually manifest as autosomal dominant traits. BDA2 was described first in a large Norwegian kindred. BDA2 is caused by mutations in BMPR1B gene and studies demonstrate that these mutations function as dominant negatives in vitro and in vivo"|function:On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMPS/OP-1|comment:mint|function:"Defects in BMPR1B are the cause of acromesomelic chondrodysplasia with genital anomalies [MIM:609441]. Acromesomelic chondrodysplasias are rare hereditary skeletal disorders characterized by short stature, very short limbs, and hand/foot malformations. The severity of limb abnormalities increases from proximal to distal with profoundly affected hands and feet showing brachydactyly and/or rudimentary fingers (knob-like fingers)"	-	comment:homomint|comment:mint|figure legend:T2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:7.2x10^-9(molar)	2009/09/23	2014/10/16	rogid:4R1OzI0j8xrONBb1/IXp8MOsaLc9606	rogid:XuFrOBMwPSqof5Lwo7v6IyzNWX09606	intact-crc:6FC2FA037384F621|rigid:b2kcBr/GIj6qiIKrroWvHpkDOGo	false	mutation decreasing interaction:22-22(MINT-7264591)|mutation decreasing interaction:23-23(MINT-7264598)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O00238	uniprotkb:P12643	intact:EBI-7527193|uniprotkb:P78366|uniprotkb:B2R953|uniprotkb:B4DSV1|intact:MINT-1340235|ensembl:ENSP00000264568|ensembl:ENSP00000378389|ensembl:ENSP00000421671|ensembl:ENSP00000425444|ensembl:ENSP00000426617|ensembl:ENSP00000500035	intact:EBI-1029262|ensembl:ENSP00000368104	psi-mi:bmr1b_human(display_long)|uniprotkb:BMPR1B(gene name)|psi-mi:BMPR1B(display_short)	psi-mi:bmp2_human(display_long)|uniprotkb:BMP2(gene name)|psi-mi:BMP2(display_short)|uniprotkb:BMP2A(gene name synonym)|uniprotkb:Bone morphogenetic protein 2A(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Kotzsch et al. (2009)	mint:MINT-7263386|pubmed:19229295|imex:IM-14029|doi:10.1038/emboj.2009.37	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8571783|mint:MINT-7264575|imex:IM-14029-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_011530503.1|refseq:NP_001194.1|refseq:NP_001243721.1|refseq:NP_001243722.1|refseq:NP_001243723.1|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0060041"(retina development in camera-type eye)|go:"GO:0060350"(endochondral bone morphogenesis)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0098821"(BMP receptor activity)|go:"GO:0140537"(transcription regulator activator activity)|go:"GO:1902043"(positive regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1902731"(negative regulation of chondrocyte proliferation)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:1990712"(HFE-transferrin receptor complex)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003605(TGF beta receptor, GS motif)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:O00238|rcsb pdb:3MDY|reactome:R-HSA-201451|refseq:XP_016864047.1|refseq:XP_016864048.1|refseq:XP_016864049.1|refseq:XP_016864050.1|ensembl:ENSG00000138696(gene)|ensembl:ENST00000264568(transcript)|ensembl:ENST00000394931(transcript)|ensembl:ENST00000509540(transcript)|ensembl:ENST00000512312(transcript)|ensembl:ENST00000515059(transcript)|ensembl:ENST00000672698(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0001502"(cartilage condensation)|go:"GO:0001550"(ovarian cumulus expansion)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001654"(eye development)|go:"GO:0002063"(chondrocyte development)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004675"(transmembrane receptor protein serine/threonine kinase activity)|go:"GO:0005025"(transforming growth factor beta receptor activity, type I)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0019211"(phosphatase activator activity)|go:"GO:0030166"(proteoglycan biosynthetic process)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0031290"(retinal ganglion cell axon guidance)|go:"GO:0032332"(positive regulation of chondrocyte differentiation)|go:"GO:0035108"(limb morphogenesis)|go:"GO:0036122"(BMP binding)|go:"GO:0042698"(ovulation cycle)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043235"(receptor complex)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|mint:MINT-7264580(identity)	refseq:NP_001191.1|ensembl:ENSG00000125845(gene)|ensembl:ENST00000378827(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001501"(skeletal system development)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0003130"(BMP signaling pathway involved in heart induction)|go:"GO:0003176"(aortic valve development)|go:"GO:0003181"(atrioventricular valve morphogenesis)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003210"(cardiac atrium formation)|go:"GO:0003272"(endocardial cushion formation)|go:"GO:0003308"(negative regulation of Wnt signaling pathway involved in heart development)|go:"GO:0003331"(positive regulation of extracellular matrix constituent secretion)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0006029"(proteoglycan metabolic process)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0007507"(heart development)|go:"GO:0008083"(growth factor activity)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009617"(response to bacterium)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0010894"(negative regulation of steroid biosynthetic process)|go:"GO:0010922"(positive regulation of phosphatase activity)|go:"GO:0019211"(phosphatase activator activity)|go:"GO:0021537"(telencephalon development)|go:"GO:0021978"(telencephalon regionalization)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0030282"(bone mineralization)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031648"(protein destabilization)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032348"(negative regulation of aldosterone biosynthetic process)|go:"GO:0033690"(positive regulation of osteoblast proliferation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:0035051"(cardiocyte differentiation)|go:"GO:1905072"(cardiac jelly development)|go:"GO:0035054"(embryonic heart tube anterior/posterior pattern specification)|go:"GO:0035360"(positive regulation of peroxisome proliferator activated receptor signaling pathway)|go:"GO:1905222"(atrioventricular canal morphogenesis)|go:"GO:0035630"(bone mineralization involved in bone maturation)|go:"GO:0039706"(co-receptor binding)|go:"GO:2000065"(negative regulation of cortisol biosynthetic process)|go:"GO:2000726"(negative regulation of cardiac muscle cell differentiation)|interpro:IPR001111("Transforming growth factor beta (TGFb), N-terminal")|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042482"(positive regulation of odontogenesis)|interpro:IPR001839(Transforming growth factor beta)|interpro:IPR015615(Transforming growth factor-beta-related)|go:"GO:0042487"(regulation of odontogenesis of dentin-containing tooth)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR017948|go:"GO:0043407"(negative regulation of MAP kinase activity)|interpro:IPR029034|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0043569"(negative regulation of insulin-like growth factor receptor signaling pathway)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045778"(positive regulation of ossification)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0048711"(positive regulation of astrocyte differentiation)|go:"GO:0048762"(mesenchymal cell differentiation)|go:"GO:0048839"(inner ear development)|go:"GO:0051042"(negative regulation of calcium-independent cell-cell adhesion)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0055008"(cardiac muscle tissue morphogenesis)|go:"GO:0060039"(pericardium development)|go:"GO:0060128"(corticotropin hormone secreting cell differentiation)|go:"GO:0060129"(thyroid-stimulating hormone-secreting cell differentiation)|go:"GO:0060317"(cardiac epithelial to mesenchymal transition)|go:"GO:0060389"(pathway-restricted SMAD protein phosphorylation)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0060485"(mesenchyme development)|go:"GO:0060804"(positive regulation of Wnt signaling pathway by BMP signaling pathway)|mint:P12643|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0061312"(BMP signaling pathway involved in heart development)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070700"(BMP receptor binding)|go:"GO:0070724"(BMP receptor complex)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0072138"(mesenchymal cell proliferation involved in ureteric bud development)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0140537"(transcription regulator activator activity)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|rcsb pdb:1ES7|rcsb pdb:1REU|rcsb pdb:1REW|rcsb pdb:2GOO|rcsb pdb:2H62|rcsb pdb:2H64|rcsb pdb:2QJ9|rcsb pdb:2QJA|rcsb pdb:2QJB|rcsb pdb:3BK3|rcsb pdb:3BMP|rcsb pdb:4MID|rcsb pdb:4N1D|rcsb pdb:4UHY|rcsb pdb:4UHZ|rcsb pdb:4UI0|rcsb pdb:4UI1|rcsb pdb:4UI2|rcsb pdb:6OMN|reactome:R-HSA-201451|reactome:R-HSA-2129379|reactome:R-HSA-8878166|reactome:R-HSA-8939902|dip:DIP-5792N|mint:MINT-7264578(identity)	-	function:"Defects in BMPR1B are a cause of brachydactyly type A2 (BDA2) [MIM:112600]. Brachydactylies (BDs) are a group of inherited malformations characterized by shortening of the digits due to abnormal development of the phalanges and/or the metacarpals. They have been classified on an anatomic and genetic basis into five groups, A to E, including three subgroups (A1 to A3) that usually manifest as autosomal dominant traits. BDA2 was described first in a large Norwegian kindred. BDA2 is caused by mutations in BMPR1B gene and studies demonstrate that these mutations function as dominant negatives in vitro and in vivo"|function:On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for BMPS/OP-1|comment:mint|function:"Defects in BMPR1B are the cause of acromesomelic chondrodysplasia with genital anomalies [MIM:609441]. Acromesomelic chondrodysplasias are rare hereditary skeletal disorders characterized by short stature, very short limbs, and hand/foot malformations. The severity of limb abnormalities increases from proximal to distal with profoundly affected hands and feet showing brachydactyly and/or rudimentary fingers (knob-like fingers)"	-	comment:homomint|comment:mint|figure legend:T2|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:2.17x10^-8(molar)	2009/09/23	2014/10/16	rogid:4R1OzI0j8xrONBb1/IXp8MOsaLc9606	rogid:XuFrOBMwPSqof5Lwo7v6IyzNWX09606	intact-crc:C5263455154EF041|rigid:b2kcBr/GIj6qiIKrroWvHpkDOGo	false	mutation decreasing interaction:67-67(MINT-7264581)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P43026	uniprotkb:Q13873	intact:EBI-8571476|ensembl:ENSP00000363489|ensembl:ENSP00000363492|uniprotkb:Q96SB1|intact:MINT-7264433|uniprotkb:E1P5Q2	intact:EBI-527196|uniprotkb:Q16569|uniprotkb:Q13161|uniprotkb:Q4ZG08|uniprotkb:Q53SA5|uniprotkb:Q585T8|ensembl:ENSP00000363708	psi-mi:gdf5_human(display_long)|uniprotkb:GDF5(gene name)|psi-mi:GDF5(display_short)|uniprotkb:CDMP1(gene name synonym)|uniprotkb:Cartilage-derived morphogenetic protein 1(gene name synonym)|uniprotkb:Radotermin(gene name synonym)|uniprotkb:BMP14(gene name synonym)|uniprotkb:Bone morphogenetic protein 14(gene name synonym)|uniprotkb:Lipopolysaccharide-associated protein 4(gene name synonym)	psi-mi:bmpr2_human(display_long)|uniprotkb:Bone morphogenetic protein receptor type II(gene name synonym)|uniprotkb:PPH1(gene name synonym)|uniprotkb:BMPR2(gene name)|psi-mi:BMPR2(display_short)	psi-mi:"MI:0107"(surface plasmon resonance)	Kotzsch et al. (2009)	mint:MINT-7263386|pubmed:19229295|imex:IM-14029|doi:10.1038/emboj.2009.37	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8571872|mint:MINT-7264601|imex:IM-14029-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001306067.1|ensembl:ENSG00000125965(gene)|ensembl:ENST00000374369(transcript)|ensembl:ENST00000374372(transcript)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008083"(growth factor activity)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0032332"(positive regulation of chondrocyte differentiation)|go:"GO:0035136"(forelimb morphogenesis)|go:"GO:0035137"(hindlimb morphogenesis)|go:"GO:0036122"(BMP binding)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043932"(ossification involved in bone remodeling)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0060390"(regulation of SMAD protein signal transduction)|go:"GO:0060395"(SMAD protein signal transduction)|interpro:IPR001839(Transforming growth factor beta)|interpro:IPR015615(Transforming growth factor-beta-related)|interpro:IPR017948|interpro:IPR029034|mint:P43026|rcsb pdb:1WAQ|rcsb pdb:2BHK|rcsb pdb:3EVS|rcsb pdb:3QB4|rcsb pdb:5HK5|rcsb pdb:6Z3G|rcsb pdb:6Z3H|go:"GO:0060591"(chondroblast differentiation)|go:"GO:2001054"(negative regulation of mesenchymal cell apoptotic process)|interpro:IPR001111("Transforming growth factor beta (TGFb), N-terminal")|rcsb pdb:6Z3J|rcsb pdb:6Z3L|rcsb pdb:6Z3M|reactome:R-HSA-2129379|refseq:NP_000548.2|dip:DIP-5823N|refseq:XP_011527377.1|mint:MINT-7264604(identity)	dip:DIP-5794N|refseq:NP_001195.2|ensembl:ENSG00000204217(gene)|ensembl:ENST00000374580(transcript)|go:"GO:0001568"(blood vessel development)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001893"(maternal placenta development)|go:"GO:0001935"(endothelial cell proliferation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001946"(lymphangiogenesis)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002063"(chondrocyte development)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003176"(aortic valve development)|go:"GO:0003177"(pulmonary valve development)|go:"GO:0003183"(mitral valve morphogenesis)|go:"GO:0003186"(tricuspid valve morphogenesis)|go:"GO:0003197"(endocardial cushion development)|go:"GO:0003252"(negative regulation of cell proliferation involved in heart valve morphogenesis)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005024"(transforming growth factor beta-activated receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005912"(adherens junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007178"(transmembrane receptor protein serine/threonine kinase signaling pathway)|go:"GO:0007420"(brain development)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0014916"(regulation of lung blood pressure)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016362"(activin receptor activity, type II)|go:"GO:0019211"(phosphatase activator activity)|go:"GO:0019838"(growth factor binding)|go:"GO:0030166"(proteoglycan biosynthetic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0030546"(signaling receptor activator activity)|go:"GO:0036122"(BMP binding)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043235"(receptor complex)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0044214"(spanning component of plasma membrane)|go:"GO:0045296"(cadherin binding)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045778"(positive regulation of ossification)|go:"GO:0045906"(negative regulation of vasoconstriction)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048286"(lung alveolus development)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0048842"(positive regulation of axon extension involved in axon guidance)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0060173"(limb development)|go:"GO:0060350"(endochondral bone morphogenesis)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060413"(atrial septum morphogenesis)|go:"GO:0060836"(lymphatic endothelial cell differentiation)|go:"GO:0060840"(artery development)|go:"GO:0060841"(venous blood vessel development)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0061298"(retina vasculature development in camera-type eye)|go:"GO:0061626"(pharyngeal arch artery morphogenesis)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0014069"(postsynaptic density)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0098821"(BMP receptor activity)|go:"GO:0140537"(transcription regulator activator activity)|go:"GO:1902731"(negative regulation of chondrocyte proliferation)|go:"GO:1905314"(semi-lunar valve development)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000279"(negative regulation of DNA biosynthetic process)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015770(Bone morphogenic protein type II receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q13873|rcsb pdb:2HLQ|rcsb pdb:3G2F|reactome:R-HSA-201451|go:"GO:0071773"(cellular response to BMP stimulus)|mint:MINT-7264608(identity)	-	comment:mint	-	figure legend:T3|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:3.19x10^-8(molar)	2009/09/23	2014/10/16	rogid:1+H+MmShXRpzq5qIDid7rv8ApMk9606	rogid:ZnEZsCvOyBegC07WvkGwXMz6jAw9606	intact-crc:26D02DD7F57A7F61|rigid:wY3QJj4vhrIRg0nSgH6TD4QacBw	false	mutation increasing interaction:60-60(MINT-7264605)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P43026	uniprotkb:Q13873	intact:EBI-8571476|ensembl:ENSP00000363489|ensembl:ENSP00000363492|uniprotkb:Q96SB1|intact:MINT-7264433|uniprotkb:E1P5Q2	intact:EBI-527196|uniprotkb:Q16569|uniprotkb:Q13161|uniprotkb:Q4ZG08|uniprotkb:Q53SA5|uniprotkb:Q585T8|ensembl:ENSP00000363708	psi-mi:gdf5_human(display_long)|uniprotkb:GDF5(gene name)|psi-mi:GDF5(display_short)|uniprotkb:CDMP1(gene name synonym)|uniprotkb:Cartilage-derived morphogenetic protein 1(gene name synonym)|uniprotkb:Radotermin(gene name synonym)|uniprotkb:BMP14(gene name synonym)|uniprotkb:Bone morphogenetic protein 14(gene name synonym)|uniprotkb:Lipopolysaccharide-associated protein 4(gene name synonym)	psi-mi:bmpr2_human(display_long)|uniprotkb:Bone morphogenetic protein receptor type II(gene name synonym)|uniprotkb:PPH1(gene name synonym)|uniprotkb:BMPR2(gene name)|psi-mi:BMPR2(display_short)	psi-mi:"MI:0107"(surface plasmon resonance)	Kotzsch et al. (2009)	mint:MINT-7263386|pubmed:19229295|imex:IM-14029|doi:10.1038/emboj.2009.37	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8571940|mint:MINT-7264614|imex:IM-14029-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001306067.1|ensembl:ENSG00000125965(gene)|ensembl:ENST00000374369(transcript)|ensembl:ENST00000374372(transcript)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008083"(growth factor activity)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0032332"(positive regulation of chondrocyte differentiation)|go:"GO:0035136"(forelimb morphogenesis)|go:"GO:0035137"(hindlimb morphogenesis)|go:"GO:0036122"(BMP binding)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043932"(ossification involved in bone remodeling)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0060390"(regulation of SMAD protein signal transduction)|go:"GO:0060395"(SMAD protein signal transduction)|interpro:IPR001839(Transforming growth factor beta)|interpro:IPR015615(Transforming growth factor-beta-related)|interpro:IPR017948|interpro:IPR029034|mint:P43026|rcsb pdb:1WAQ|rcsb pdb:2BHK|rcsb pdb:3EVS|rcsb pdb:3QB4|rcsb pdb:5HK5|rcsb pdb:6Z3G|rcsb pdb:6Z3H|go:"GO:0060591"(chondroblast differentiation)|go:"GO:2001054"(negative regulation of mesenchymal cell apoptotic process)|interpro:IPR001111("Transforming growth factor beta (TGFb), N-terminal")|rcsb pdb:6Z3J|rcsb pdb:6Z3L|rcsb pdb:6Z3M|reactome:R-HSA-2129379|refseq:NP_000548.2|dip:DIP-5823N|refseq:XP_011527377.1|mint:MINT-7264619(identity)	dip:DIP-5794N|refseq:NP_001195.2|ensembl:ENSG00000204217(gene)|ensembl:ENST00000374580(transcript)|go:"GO:0001568"(blood vessel development)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001893"(maternal placenta development)|go:"GO:0001935"(endothelial cell proliferation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001946"(lymphangiogenesis)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002063"(chondrocyte development)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003176"(aortic valve development)|go:"GO:0003177"(pulmonary valve development)|go:"GO:0003183"(mitral valve morphogenesis)|go:"GO:0003186"(tricuspid valve morphogenesis)|go:"GO:0003197"(endocardial cushion development)|go:"GO:0003252"(negative regulation of cell proliferation involved in heart valve morphogenesis)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005024"(transforming growth factor beta-activated receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005912"(adherens junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007178"(transmembrane receptor protein serine/threonine kinase signaling pathway)|go:"GO:0007420"(brain development)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0014916"(regulation of lung blood pressure)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016362"(activin receptor activity, type II)|go:"GO:0019211"(phosphatase activator activity)|go:"GO:0019838"(growth factor binding)|go:"GO:0030166"(proteoglycan biosynthetic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0030546"(signaling receptor activator activity)|go:"GO:0036122"(BMP binding)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043235"(receptor complex)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0044214"(spanning component of plasma membrane)|go:"GO:0045296"(cadherin binding)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045778"(positive regulation of ossification)|go:"GO:0045906"(negative regulation of vasoconstriction)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048286"(lung alveolus development)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0048842"(positive regulation of axon extension involved in axon guidance)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0060173"(limb development)|go:"GO:0060350"(endochondral bone morphogenesis)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060413"(atrial septum morphogenesis)|go:"GO:0060836"(lymphatic endothelial cell differentiation)|go:"GO:0060840"(artery development)|go:"GO:0060841"(venous blood vessel development)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0061298"(retina vasculature development in camera-type eye)|go:"GO:0061626"(pharyngeal arch artery morphogenesis)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0014069"(postsynaptic density)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0098821"(BMP receptor activity)|go:"GO:0140537"(transcription regulator activator activity)|go:"GO:1902731"(negative regulation of chondrocyte proliferation)|go:"GO:1905314"(semi-lunar valve development)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000279"(negative regulation of DNA biosynthetic process)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015770(Bone morphogenic protein type II receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q13873|rcsb pdb:2HLQ|rcsb pdb:3G2F|reactome:R-HSA-201451|go:"GO:0071773"(cellular response to BMP stimulus)|mint:MINT-7264617(identity)	-	comment:mint	-	figure legend:T3|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:5.59x10^-8(molar)	2009/09/23	2014/10/16	rogid:1+H+MmShXRpzq5qIDid7rv8ApMk9606	rogid:ZnEZsCvOyBegC07WvkGwXMz6jAw9606	intact-crc:DBD0B40EA76ABEB4|rigid:wY3QJj4vhrIRg0nSgH6TD4QacBw	false	mutation increasing interaction:57-57(MINT-7264620)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P43026	uniprotkb:Q13873	intact:EBI-8571476|ensembl:ENSP00000363489|ensembl:ENSP00000363492|uniprotkb:Q96SB1|intact:MINT-7264433|uniprotkb:E1P5Q2	intact:EBI-527196|uniprotkb:Q16569|uniprotkb:Q13161|uniprotkb:Q4ZG08|uniprotkb:Q53SA5|uniprotkb:Q585T8|ensembl:ENSP00000363708	psi-mi:gdf5_human(display_long)|uniprotkb:GDF5(gene name)|psi-mi:GDF5(display_short)|uniprotkb:CDMP1(gene name synonym)|uniprotkb:Cartilage-derived morphogenetic protein 1(gene name synonym)|uniprotkb:Radotermin(gene name synonym)|uniprotkb:BMP14(gene name synonym)|uniprotkb:Bone morphogenetic protein 14(gene name synonym)|uniprotkb:Lipopolysaccharide-associated protein 4(gene name synonym)	psi-mi:bmpr2_human(display_long)|uniprotkb:Bone morphogenetic protein receptor type II(gene name synonym)|uniprotkb:PPH1(gene name synonym)|uniprotkb:BMPR2(gene name)|psi-mi:BMPR2(display_short)	psi-mi:"MI:0107"(surface plasmon resonance)	Kotzsch et al. (2009)	mint:MINT-7263386|pubmed:19229295|imex:IM-14029|doi:10.1038/emboj.2009.37	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8572028|mint:MINT-7264638|imex:IM-14029-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001306067.1|ensembl:ENSG00000125965(gene)|ensembl:ENST00000374369(transcript)|ensembl:ENST00000374372(transcript)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008083"(growth factor activity)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0032332"(positive regulation of chondrocyte differentiation)|go:"GO:0035136"(forelimb morphogenesis)|go:"GO:0035137"(hindlimb morphogenesis)|go:"GO:0036122"(BMP binding)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043932"(ossification involved in bone remodeling)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0060390"(regulation of SMAD protein signal transduction)|go:"GO:0060395"(SMAD protein signal transduction)|interpro:IPR001839(Transforming growth factor beta)|interpro:IPR015615(Transforming growth factor-beta-related)|interpro:IPR017948|interpro:IPR029034|mint:P43026|rcsb pdb:1WAQ|rcsb pdb:2BHK|rcsb pdb:3EVS|rcsb pdb:3QB4|rcsb pdb:5HK5|rcsb pdb:6Z3G|rcsb pdb:6Z3H|go:"GO:0060591"(chondroblast differentiation)|go:"GO:2001054"(negative regulation of mesenchymal cell apoptotic process)|interpro:IPR001111("Transforming growth factor beta (TGFb), N-terminal")|rcsb pdb:6Z3J|rcsb pdb:6Z3L|rcsb pdb:6Z3M|reactome:R-HSA-2129379|refseq:NP_000548.2|dip:DIP-5823N|refseq:XP_011527377.1|mint:MINT-7264643(identity)	dip:DIP-5794N|refseq:NP_001195.2|ensembl:ENSG00000204217(gene)|ensembl:ENST00000374580(transcript)|go:"GO:0001568"(blood vessel development)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001893"(maternal placenta development)|go:"GO:0001935"(endothelial cell proliferation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001946"(lymphangiogenesis)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002063"(chondrocyte development)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003176"(aortic valve development)|go:"GO:0003177"(pulmonary valve development)|go:"GO:0003183"(mitral valve morphogenesis)|go:"GO:0003186"(tricuspid valve morphogenesis)|go:"GO:0003197"(endocardial cushion development)|go:"GO:0003252"(negative regulation of cell proliferation involved in heart valve morphogenesis)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005024"(transforming growth factor beta-activated receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005912"(adherens junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007178"(transmembrane receptor protein serine/threonine kinase signaling pathway)|go:"GO:0007420"(brain development)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0014916"(regulation of lung blood pressure)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016362"(activin receptor activity, type II)|go:"GO:0019211"(phosphatase activator activity)|go:"GO:0019838"(growth factor binding)|go:"GO:0030166"(proteoglycan biosynthetic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0030546"(signaling receptor activator activity)|go:"GO:0036122"(BMP binding)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043235"(receptor complex)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0044214"(spanning component of plasma membrane)|go:"GO:0045296"(cadherin binding)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045778"(positive regulation of ossification)|go:"GO:0045906"(negative regulation of vasoconstriction)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048286"(lung alveolus development)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0048842"(positive regulation of axon extension involved in axon guidance)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0060173"(limb development)|go:"GO:0060350"(endochondral bone morphogenesis)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060413"(atrial septum morphogenesis)|go:"GO:0060836"(lymphatic endothelial cell differentiation)|go:"GO:0060840"(artery development)|go:"GO:0060841"(venous blood vessel development)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0061298"(retina vasculature development in camera-type eye)|go:"GO:0061626"(pharyngeal arch artery morphogenesis)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0014069"(postsynaptic density)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0098821"(BMP receptor activity)|go:"GO:0140537"(transcription regulator activator activity)|go:"GO:1902731"(negative regulation of chondrocyte proliferation)|go:"GO:1905314"(semi-lunar valve development)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000279"(negative regulation of DNA biosynthetic process)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015770(Bone morphogenic protein type II receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q13873|rcsb pdb:2HLQ|rcsb pdb:3G2F|reactome:R-HSA-201451|go:"GO:0071773"(cellular response to BMP stimulus)|mint:MINT-7264641(identity)	-	comment:mint	-	figure legend:T3|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:6.58x10^-8(molar)	2009/09/23	2014/10/16	rogid:1+H+MmShXRpzq5qIDid7rv8ApMk9606	rogid:ZnEZsCvOyBegC07WvkGwXMz6jAw9606	intact-crc:F14DE032C6863FDA|rigid:wY3QJj4vhrIRg0nSgH6TD4QacBw	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P43026	uniprotkb:Q13873	intact:EBI-8571476|ensembl:ENSP00000363489|ensembl:ENSP00000363492|uniprotkb:Q96SB1|intact:MINT-7264433|uniprotkb:E1P5Q2	intact:EBI-527196|uniprotkb:Q16569|uniprotkb:Q13161|uniprotkb:Q4ZG08|uniprotkb:Q53SA5|uniprotkb:Q585T8|ensembl:ENSP00000363708	psi-mi:gdf5_human(display_long)|uniprotkb:GDF5(gene name)|psi-mi:GDF5(display_short)|uniprotkb:CDMP1(gene name synonym)|uniprotkb:Cartilage-derived morphogenetic protein 1(gene name synonym)|uniprotkb:Radotermin(gene name synonym)|uniprotkb:BMP14(gene name synonym)|uniprotkb:Bone morphogenetic protein 14(gene name synonym)|uniprotkb:Lipopolysaccharide-associated protein 4(gene name synonym)	psi-mi:bmpr2_human(display_long)|uniprotkb:Bone morphogenetic protein receptor type II(gene name synonym)|uniprotkb:PPH1(gene name synonym)|uniprotkb:BMPR2(gene name)|psi-mi:BMPR2(display_short)	psi-mi:"MI:0107"(surface plasmon resonance)	Kotzsch et al. (2009)	mint:MINT-7263386|pubmed:19229295|imex:IM-14029|doi:10.1038/emboj.2009.37	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8571998|mint:MINT-7264626|imex:IM-14029-12	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001306067.1|ensembl:ENSG00000125965(gene)|ensembl:ENST00000374369(transcript)|ensembl:ENST00000374372(transcript)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008083"(growth factor activity)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0032332"(positive regulation of chondrocyte differentiation)|go:"GO:0035136"(forelimb morphogenesis)|go:"GO:0035137"(hindlimb morphogenesis)|go:"GO:0036122"(BMP binding)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043932"(ossification involved in bone remodeling)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0060390"(regulation of SMAD protein signal transduction)|go:"GO:0060395"(SMAD protein signal transduction)|interpro:IPR001839(Transforming growth factor beta)|interpro:IPR015615(Transforming growth factor-beta-related)|interpro:IPR017948|interpro:IPR029034|mint:P43026|rcsb pdb:1WAQ|rcsb pdb:2BHK|rcsb pdb:3EVS|rcsb pdb:3QB4|rcsb pdb:5HK5|rcsb pdb:6Z3G|rcsb pdb:6Z3H|go:"GO:0060591"(chondroblast differentiation)|go:"GO:2001054"(negative regulation of mesenchymal cell apoptotic process)|interpro:IPR001111("Transforming growth factor beta (TGFb), N-terminal")|rcsb pdb:6Z3J|rcsb pdb:6Z3L|rcsb pdb:6Z3M|reactome:R-HSA-2129379|refseq:NP_000548.2|dip:DIP-5823N|refseq:XP_011527377.1|mint:MINT-7264629(identity)	dip:DIP-5794N|refseq:NP_001195.2|ensembl:ENSG00000204217(gene)|ensembl:ENST00000374580(transcript)|go:"GO:0001568"(blood vessel development)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001893"(maternal placenta development)|go:"GO:0001935"(endothelial cell proliferation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001946"(lymphangiogenesis)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002063"(chondrocyte development)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003176"(aortic valve development)|go:"GO:0003177"(pulmonary valve development)|go:"GO:0003183"(mitral valve morphogenesis)|go:"GO:0003186"(tricuspid valve morphogenesis)|go:"GO:0003197"(endocardial cushion development)|go:"GO:0003252"(negative regulation of cell proliferation involved in heart valve morphogenesis)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005024"(transforming growth factor beta-activated receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005912"(adherens junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007178"(transmembrane receptor protein serine/threonine kinase signaling pathway)|go:"GO:0007420"(brain development)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0014916"(regulation of lung blood pressure)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016362"(activin receptor activity, type II)|go:"GO:0019211"(phosphatase activator activity)|go:"GO:0019838"(growth factor binding)|go:"GO:0030166"(proteoglycan biosynthetic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0030546"(signaling receptor activator activity)|go:"GO:0036122"(BMP binding)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043235"(receptor complex)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0044214"(spanning component of plasma membrane)|go:"GO:0045296"(cadherin binding)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045778"(positive regulation of ossification)|go:"GO:0045906"(negative regulation of vasoconstriction)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048286"(lung alveolus development)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0048842"(positive regulation of axon extension involved in axon guidance)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0060173"(limb development)|go:"GO:0060350"(endochondral bone morphogenesis)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060413"(atrial septum morphogenesis)|go:"GO:0060836"(lymphatic endothelial cell differentiation)|go:"GO:0060840"(artery development)|go:"GO:0060841"(venous blood vessel development)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0061298"(retina vasculature development in camera-type eye)|go:"GO:0061626"(pharyngeal arch artery morphogenesis)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0014069"(postsynaptic density)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0098821"(BMP receptor activity)|go:"GO:0140537"(transcription regulator activator activity)|go:"GO:1902731"(negative regulation of chondrocyte proliferation)|go:"GO:1905314"(semi-lunar valve development)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000279"(negative regulation of DNA biosynthetic process)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015770(Bone morphogenic protein type II receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q13873|rcsb pdb:2HLQ|rcsb pdb:3G2F|reactome:R-HSA-201451|go:"GO:0071773"(cellular response to BMP stimulus)|mint:MINT-7264633(identity)	-	comment:mint	-	figure legend:T3|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:7.244x10^-8(molar)	2009/09/23	2014/10/16	rogid:1+H+MmShXRpzq5qIDid7rv8ApMk9606	rogid:ZnEZsCvOyBegC07WvkGwXMz6jAw9606	intact-crc:0855DF34FA47DC44|rigid:wY3QJj4vhrIRg0nSgH6TD4QacBw	false	mutation decreasing interaction:57-57(MINT-7264630)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P43026	uniprotkb:P36894	intact:EBI-8571476|ensembl:ENSP00000363489|ensembl:ENSP00000363492|uniprotkb:Q96SB1|intact:MINT-7264433|uniprotkb:E1P5Q2	intact:EBI-1029237|uniprotkb:Q8NEN8|uniprotkb:A8K6U9|ensembl:ENSP00000361107|ensembl:ENSP00000489707|ensembl:ENSP00000490273|ensembl:ENSP00000492290	psi-mi:gdf5_human(display_long)|uniprotkb:GDF5(gene name)|psi-mi:GDF5(display_short)|uniprotkb:CDMP1(gene name synonym)|uniprotkb:Cartilage-derived morphogenetic protein 1(gene name synonym)|uniprotkb:Radotermin(gene name synonym)|uniprotkb:BMP14(gene name synonym)|uniprotkb:Bone morphogenetic protein 14(gene name synonym)|uniprotkb:Lipopolysaccharide-associated protein 4(gene name synonym)	psi-mi:bmr1a_human(display_long)|uniprotkb:ACVRLK3(gene name synonym)|uniprotkb:ALK3(gene name synonym)|uniprotkb:BMPR1A(gene name)|psi-mi:BMPR1A(display_short)|uniprotkb:Serine/threonine-protein kinase receptor R5(gene name synonym)|uniprotkb:Activin receptor-like kinase 3(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Kotzsch et al. (2009)	mint:MINT-7263386|pubmed:19229295|imex:IM-14029|doi:10.1038/emboj.2009.37	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8572102|mint:MINT-7264663|imex:IM-14029-15	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001306067.1|ensembl:ENSG00000125965(gene)|ensembl:ENST00000374369(transcript)|ensembl:ENST00000374372(transcript)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008083"(growth factor activity)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0032332"(positive regulation of chondrocyte differentiation)|go:"GO:0035136"(forelimb morphogenesis)|go:"GO:0035137"(hindlimb morphogenesis)|go:"GO:0036122"(BMP binding)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043932"(ossification involved in bone remodeling)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0060390"(regulation of SMAD protein signal transduction)|go:"GO:0060395"(SMAD protein signal transduction)|interpro:IPR001839(Transforming growth factor beta)|interpro:IPR015615(Transforming growth factor-beta-related)|interpro:IPR017948|interpro:IPR029034|mint:P43026|rcsb pdb:1WAQ|rcsb pdb:2BHK|rcsb pdb:3EVS|rcsb pdb:3QB4|rcsb pdb:5HK5|rcsb pdb:6Z3G|rcsb pdb:6Z3H|go:"GO:0060591"(chondroblast differentiation)|go:"GO:2001054"(negative regulation of mesenchymal cell apoptotic process)|interpro:IPR001111("Transforming growth factor beta (TGFb), N-terminal")|rcsb pdb:6Z3J|rcsb pdb:6Z3L|rcsb pdb:6Z3M|reactome:R-HSA-2129379|refseq:NP_000548.2|dip:DIP-5823N|refseq:XP_011527377.1|mint:MINT-7264668(identity)	refseq:NP_004320.2|ensembl:ENSG00000107779(gene)|ensembl:ENST00000372037(transcript)|ensembl:ENST00000635816(transcript)|ensembl:ENST00000636056(transcript)|ensembl:ENST00000638429(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001756"(somitogenesis)|go:"GO:0001880"(Mullerian duct regression)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0003171"(atrioventricular valve development)|go:"GO:0003183"(mitral valve morphogenesis)|go:"GO:0003186"(tricuspid valve morphogenesis)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003215"(cardiac right ventricle morphogenesis)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003223"(ventricular compact myocardium morphogenesis)|go:"GO:0003272"(endocardial cushion formation)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004675"(transmembrane receptor protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006955"(immune response)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007398"(ectoderm development)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009950"(dorsal/ventral axis specification)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0014032"(neural crest cell development)|go:"GO:0014912"(negative regulation of smooth muscle cell migration)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019211"(phosphatase activator activity)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0021983"(pituitary gland development)|go:"GO:0021998"(neural plate mediolateral regionalization)|go:"GO:0030324"(lung development)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0032915"(positive regulation of transforming growth factor beta2 production)|go:"GO:0035137"(hindlimb morphogenesis)|go:"GO:0035912"(dorsal aorta morphogenesis)|go:"GO:0036122"(BMP binding)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043235"(receptor complex)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0005025"(transforming growth factor beta receptor activity, type I)|go:"GO:0046872"(metal ion binding)|go:"GO:0048352"(paraxial mesoderm structural organization)|go:"GO:0048368"(lateral mesoderm development)|go:"GO:0048378"(regulation of lateral mesodermal cell fate specification)|go:"GO:0048382"(mesendoderm development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048589"(developmental growth)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060043"(regulation of cardiac muscle cell proliferation)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060914"(heart formation)|go:"GO:0060928"(atrioventricular node cell development)|go:"GO:0061312"(BMP signaling pathway involved in heart development)|go:"GO:0061626"(pharyngeal arch artery morphogenesis)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0098821"(BMP receptor activity)|go:"GO:0140537"(transcription regulator activator activity)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904414"(positive regulation of cardiac ventricle development)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1905285"(fibrous ring of heart morphogenesis)|go:"GO:1990712"(HFE-transferrin receptor complex)|go:"GO:2000772"(regulation of cellular senescence)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003605(TGF beta receptor, GS motif)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|go:"GO:0046332"(SMAD binding)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P36894|rcsb pdb:1ES7|rcsb pdb:1REW|rcsb pdb:2GOO|rcsb pdb:2H62|rcsb pdb:2H64|rcsb pdb:2K3G|rcsb pdb:2QJ9|rcsb pdb:2QJA|rcsb pdb:2QJB|rcsb pdb:3NH7|rcsb pdb:3QB4|reactome:R-HSA-201451|refseq:XP_011538405.1|refseq:XP_011538406.1|dip:DIP-5793N|mint:MINT-7264666(identity)	-	comment:mint	-	figure legend:T3|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:4.2x10^-9(molar)	2009/09/23	2014/10/16	rogid:1+H+MmShXRpzq5qIDid7rv8ApMk9606	rogid:FsuuuKYQ90CxQd5LwFjXnuyesYc9606	intact-crc:ACB8670BE87C25C4|rigid:gu6kQO3e+tD0AKELwjO6EpvVuWE	false	mutation increasing interaction:57-57(MINT-7264669)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P43026	uniprotkb:P36894	intact:EBI-8571476|ensembl:ENSP00000363489|ensembl:ENSP00000363492|uniprotkb:Q96SB1|intact:MINT-7264433|uniprotkb:E1P5Q2	intact:EBI-1029237|uniprotkb:Q8NEN8|uniprotkb:A8K6U9|ensembl:ENSP00000361107|ensembl:ENSP00000489707|ensembl:ENSP00000490273|ensembl:ENSP00000492290	psi-mi:gdf5_human(display_long)|uniprotkb:GDF5(gene name)|psi-mi:GDF5(display_short)|uniprotkb:CDMP1(gene name synonym)|uniprotkb:Cartilage-derived morphogenetic protein 1(gene name synonym)|uniprotkb:Radotermin(gene name synonym)|uniprotkb:BMP14(gene name synonym)|uniprotkb:Bone morphogenetic protein 14(gene name synonym)|uniprotkb:Lipopolysaccharide-associated protein 4(gene name synonym)	psi-mi:bmr1a_human(display_long)|uniprotkb:ACVRLK3(gene name synonym)|uniprotkb:ALK3(gene name synonym)|uniprotkb:BMPR1A(gene name)|psi-mi:BMPR1A(display_short)|uniprotkb:Serine/threonine-protein kinase receptor R5(gene name synonym)|uniprotkb:Activin receptor-like kinase 3(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Kotzsch et al. (2009)	mint:MINT-7263386|pubmed:19229295|imex:IM-14029|doi:10.1038/emboj.2009.37	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8572069|mint:MINT-7264650|imex:IM-14029-14	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001306067.1|ensembl:ENSG00000125965(gene)|ensembl:ENST00000374369(transcript)|ensembl:ENST00000374372(transcript)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008083"(growth factor activity)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0032332"(positive regulation of chondrocyte differentiation)|go:"GO:0035136"(forelimb morphogenesis)|go:"GO:0035137"(hindlimb morphogenesis)|go:"GO:0036122"(BMP binding)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043932"(ossification involved in bone remodeling)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0060390"(regulation of SMAD protein signal transduction)|go:"GO:0060395"(SMAD protein signal transduction)|interpro:IPR001839(Transforming growth factor beta)|interpro:IPR015615(Transforming growth factor-beta-related)|interpro:IPR017948|interpro:IPR029034|mint:P43026|rcsb pdb:1WAQ|rcsb pdb:2BHK|rcsb pdb:3EVS|rcsb pdb:3QB4|rcsb pdb:5HK5|rcsb pdb:6Z3G|rcsb pdb:6Z3H|go:"GO:0060591"(chondroblast differentiation)|go:"GO:2001054"(negative regulation of mesenchymal cell apoptotic process)|interpro:IPR001111("Transforming growth factor beta (TGFb), N-terminal")|rcsb pdb:6Z3J|rcsb pdb:6Z3L|rcsb pdb:6Z3M|reactome:R-HSA-2129379|refseq:NP_000548.2|dip:DIP-5823N|refseq:XP_011527377.1|mint:MINT-7264653(identity)	refseq:NP_004320.2|ensembl:ENSG00000107779(gene)|ensembl:ENST00000372037(transcript)|ensembl:ENST00000635816(transcript)|ensembl:ENST00000636056(transcript)|ensembl:ENST00000638429(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001756"(somitogenesis)|go:"GO:0001880"(Mullerian duct regression)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0003171"(atrioventricular valve development)|go:"GO:0003183"(mitral valve morphogenesis)|go:"GO:0003186"(tricuspid valve morphogenesis)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003215"(cardiac right ventricle morphogenesis)|go:"GO:0003222"(ventricular trabecula myocardium morphogenesis)|go:"GO:0003223"(ventricular compact myocardium morphogenesis)|go:"GO:0003272"(endocardial cushion formation)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004675"(transmembrane receptor protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006955"(immune response)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007398"(ectoderm development)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009950"(dorsal/ventral axis specification)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0014032"(neural crest cell development)|go:"GO:0014912"(negative regulation of smooth muscle cell migration)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019211"(phosphatase activator activity)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0021983"(pituitary gland development)|go:"GO:0021998"(neural plate mediolateral regionalization)|go:"GO:0030324"(lung development)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0032915"(positive regulation of transforming growth factor beta2 production)|go:"GO:0035137"(hindlimb morphogenesis)|go:"GO:0035912"(dorsal aorta morphogenesis)|go:"GO:0036122"(BMP binding)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043235"(receptor complex)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0005025"(transforming growth factor beta receptor activity, type I)|go:"GO:0046872"(metal ion binding)|go:"GO:0048352"(paraxial mesoderm structural organization)|go:"GO:0048368"(lateral mesoderm development)|go:"GO:0048378"(regulation of lateral mesodermal cell fate specification)|go:"GO:0048382"(mesendoderm development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048589"(developmental growth)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0060021"(roof of mouth development)|go:"GO:0060043"(regulation of cardiac muscle cell proliferation)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060914"(heart formation)|go:"GO:0060928"(atrioventricular node cell development)|go:"GO:0061312"(BMP signaling pathway involved in heart development)|go:"GO:0061626"(pharyngeal arch artery morphogenesis)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0098821"(BMP receptor activity)|go:"GO:0140537"(transcription regulator activator activity)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904414"(positive regulation of cardiac ventricle development)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1905285"(fibrous ring of heart morphogenesis)|go:"GO:1990712"(HFE-transferrin receptor complex)|go:"GO:2000772"(regulation of cellular senescence)|interpro:IPR000333(Activin type II receptor)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR003605(TGF beta receptor, GS motif)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|go:"GO:0046332"(SMAD binding)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P36894|rcsb pdb:1ES7|rcsb pdb:1REW|rcsb pdb:2GOO|rcsb pdb:2H62|rcsb pdb:2H64|rcsb pdb:2K3G|rcsb pdb:2QJ9|rcsb pdb:2QJA|rcsb pdb:2QJB|rcsb pdb:3NH7|rcsb pdb:3QB4|reactome:R-HSA-201451|refseq:XP_011538405.1|refseq:XP_011538406.1|dip:DIP-5793N|mint:MINT-7264657(identity)	-	comment:mint	-	figure legend:T3|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:1.62x10^-8(molar)	2009/09/23	2014/10/16	rogid:1+H+MmShXRpzq5qIDid7rv8ApMk9606	rogid:FsuuuKYQ90CxQd5LwFjXnuyesYc9606	intact-crc:6115EFF9A4C3E623|rigid:gu6kQO3e+tD0AKELwjO6EpvVuWE	false	mutation disrupting interaction:60-60(MINT-7264654)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)