#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q9SHC8	uniprotkb:Q9LZM1	intact:EBI-2292633|ensemblplants:AT2G45140.1	intact:EBI-2292648|ensemblplants:AT5G02100.1	psi-mi:vap12_arath(display_long)|uniprotkb:PVA12(gene name)|psi-mi:PVA12(display_short)|uniprotkb:VAP12(gene name synonym)|uniprotkb:Plant VAP homolog 12(gene name synonym)|uniprotkb:VAMP-associated protein 1-2(gene name synonym)|uniprotkb:T14P1.5(orf name)|uniprotkb:At2g45140(locus name)	psi-mi:orp3a_arath(display_long)|uniprotkb:UNE18(gene name synonym)|uniprotkb:OSBP-related protein 3A(gene name synonym)|uniprotkb:Protein UNFERTILIZED EMBRYO SAC 18(gene name synonym)|uniprotkb:T7H20.150(orf name)|uniprotkb:ORP3A(gene name)|psi-mi:ORP3A(display_short)|uniprotkb:At5g02100(locus name)	psi-mi:"MI:0096"(pull down)	Saravanan et al. (2009)	pubmed:19207211|imex:IM-19586	taxid:3702(arath)|taxid:3702("Arabidopsis thaliana (Mouse-ear cress)")	taxid:3702(arath)|taxid:3702("Arabidopsis thaliana (Mouse-ear cress)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2292644|imex:IM-19586-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR013783(Immunoglobulin-like fold)|refseq:NP_182039.1|interpro:IPR000535(Major sperm protein)|interpro:IPR008962(PapD-like)|interpro:IPR016763(Vesicle-associated membrane protein)|ensemblplants:AT2G45140(gene)|ensemblplants:AT2G45140.1(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006605"(protein targeting)|go:"GO:0016021"(integral component of membrane)|go:"GO:0061817"(endoplasmic reticulum-plasma membrane tethering)|go:"GO:0090158"(endoplasmic reticulum membrane organization)	refseq:NP_195830.1|interpro:IPR000648(Oxysterol-binding protein)|interpro:IPR018494|interpro:IPR037239|ensemblplants:AT5G02100(gene)|ensemblplants:AT5G02100.1(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0009567"(double fertilization forming a zygote and endosperm)|go:"GO:0015248"(sterol transporter activity)|go:"GO:0016020"(membrane)|go:"GO:0032934"(sterol binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)	-	-	-	figure legend:Figure 2b|caution:"The authors state that the \"cytosolic domain\" of PVA12 protein was used in the GST tagged construct. However the co-ordiantes of the protein region are not provided.  The UniProt record does not clearly define this region. Therefore this information could not be annotated in the entry."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/03/20	2014/10/16	rogid:hL85ZL2kg43A5dV9A/JkLGbhgtQ3702	rogid:soIZ7mZyykOXWs2PXif8Zq2U+WE3702	intact-crc:B935A18596890270|rigid:kaHcZlqLFRHvtSA+kffoDr5wS44	false	glutathione s tranferase tag:?-?	cyan fluorescent protein tag:c-c	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9LZM1	uniprotkb:Q9SHC8	intact:EBI-2292648|ensemblplants:AT5G02100.1	intact:EBI-2292633|ensemblplants:AT2G45140.1	psi-mi:orp3a_arath(display_long)|uniprotkb:UNE18(gene name synonym)|uniprotkb:OSBP-related protein 3A(gene name synonym)|uniprotkb:Protein UNFERTILIZED EMBRYO SAC 18(gene name synonym)|uniprotkb:T7H20.150(orf name)|uniprotkb:ORP3A(gene name)|psi-mi:ORP3A(display_short)|uniprotkb:At5g02100(locus name)	psi-mi:vap12_arath(display_long)|uniprotkb:PVA12(gene name)|psi-mi:PVA12(display_short)|uniprotkb:VAP12(gene name synonym)|uniprotkb:Plant VAP homolog 12(gene name synonym)|uniprotkb:VAMP-associated protein 1-2(gene name synonym)|uniprotkb:T14P1.5(orf name)|uniprotkb:At2g45140(locus name)	psi-mi:"MI:0096"(pull down)	Saravanan et al. (2009)	pubmed:19207211|imex:IM-19586	taxid:3702(arath)|taxid:3702("Arabidopsis thaliana (Mouse-ear cress)")	taxid:3702(arath)|taxid:3702("Arabidopsis thaliana (Mouse-ear cress)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2292682|imex:IM-19586-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_195830.1|interpro:IPR000648(Oxysterol-binding protein)|interpro:IPR018494|interpro:IPR037239|ensemblplants:AT5G02100(gene)|ensemblplants:AT5G02100.1(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0009567"(double fertilization forming a zygote and endosperm)|go:"GO:0015248"(sterol transporter activity)|go:"GO:0016020"(membrane)|go:"GO:0032934"(sterol binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)	interpro:IPR013783(Immunoglobulin-like fold)|refseq:NP_182039.1|interpro:IPR000535(Major sperm protein)|interpro:IPR008962(PapD-like)|interpro:IPR016763(Vesicle-associated membrane protein)|ensemblplants:AT2G45140(gene)|ensemblplants:AT2G45140.1(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006605"(protein targeting)|go:"GO:0016021"(integral component of membrane)|go:"GO:0061817"(endoplasmic reticulum-plasma membrane tethering)|go:"GO:0090158"(endoplasmic reticulum membrane organization)	-	-	-	figure legend:Figure 4|caution:"The authors state that the \"cytosolic domain\" of PVA12 protein was used in the GST tagged construct. However the co-ordiantes of the protein region are not provided.  The UniProt record does not clearly define this region. Therefore this information could not be annotated in the entry."|comment:"The authors conclude \"our results indicate that disruption of the PVA12-ORP3a398AAGGTG403 interaction is specific to the mutations of the WFDE region, rather than resulting from secondary effects of the mutations on protein folding\"."|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/03/20	2014/10/16	rogid:soIZ7mZyykOXWs2PXif8Zq2U+WE3702	rogid:hL85ZL2kg43A5dV9A/JkLGbhgtQ3702	intact-crc:CEF5D54313CBCDBC|rigid:kaHcZlqLFRHvtSA+kffoDr5wS44	false	his tag:?-?|mutation disrupting interaction:401-401,403-403,398-398,399-399,400-400	glutathione s tranferase tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q9SHC8	uniprotkb:Q9LZM1	intact:EBI-2292633|ensemblplants:AT2G45140.1	intact:EBI-2292648|ensemblplants:AT5G02100.1	psi-mi:vap12_arath(display_long)|uniprotkb:PVA12(gene name)|psi-mi:PVA12(display_short)|uniprotkb:VAP12(gene name synonym)|uniprotkb:Plant VAP homolog 12(gene name synonym)|uniprotkb:VAMP-associated protein 1-2(gene name synonym)|uniprotkb:T14P1.5(orf name)|uniprotkb:At2g45140(locus name)	psi-mi:orp3a_arath(display_long)|uniprotkb:UNE18(gene name synonym)|uniprotkb:OSBP-related protein 3A(gene name synonym)|uniprotkb:Protein UNFERTILIZED EMBRYO SAC 18(gene name synonym)|uniprotkb:T7H20.150(orf name)|uniprotkb:ORP3A(gene name)|psi-mi:ORP3A(display_short)|uniprotkb:At5g02100(locus name)	psi-mi:"MI:0809"(bimolecular fluorescence complementation)	Saravanan et al. (2009)	pubmed:19207211|imex:IM-19586	taxid:3702(arath)|taxid:3702("Arabidopsis thaliana (Mouse-ear cress)")	taxid:3702(arath)|taxid:3702("Arabidopsis thaliana (Mouse-ear cress)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2292670|imex:IM-19586-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR013783(Immunoglobulin-like fold)|refseq:NP_182039.1|interpro:IPR000535(Major sperm protein)|interpro:IPR008962(PapD-like)|interpro:IPR016763(Vesicle-associated membrane protein)|ensemblplants:AT2G45140(gene)|ensemblplants:AT2G45140.1(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006605"(protein targeting)|go:"GO:0016021"(integral component of membrane)|go:"GO:0061817"(endoplasmic reticulum-plasma membrane tethering)|go:"GO:0090158"(endoplasmic reticulum membrane organization)	refseq:NP_195830.1|interpro:IPR000648(Oxysterol-binding protein)|interpro:IPR018494|interpro:IPR037239|ensemblplants:AT5G02100(gene)|ensemblplants:AT5G02100.1(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0009567"(double fertilization forming a zygote and endosperm)|go:"GO:0015248"(sterol transporter activity)|go:"GO:0016020"(membrane)|go:"GO:0032934"(sterol binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)	go:"GO:0005783"(endoplasmic reticulum)	-	-	figure legend:Figure 3|comment:The authors state that the proteins interacted within the endoplasmic reticulum.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4097(tobac-leaf)|taxid:4097("Nicotiana tabacum (tobacco) leaf")	-	2009/03/20	2014/10/16	rogid:hL85ZL2kg43A5dV9A/JkLGbhgtQ3702	rogid:soIZ7mZyykOXWs2PXif8Zq2U+WE3702	intact-crc:499BAA4454AEE288|rigid:kaHcZlqLFRHvtSA+kffoDr5wS44	false	yellow fluorescent protein tag:n-n	yellow fluorescent protein tag:c-c|mutation disrupting interaction:401-401,403-403,398-398,399-399,400-400	-	-	psi-mi:"MI:0867"(tag visualisation by fluorescence)	psi-mi:"MI:0867"(tag visualisation by fluorescence)
intact:EBI-2460668	uniprotkb:Q9LZM1	-	intact:EBI-2292648|ensemblplants:AT5G02100.1	psi-mi:sitosterol(display_short)|psi-mi:EBI-2460668(display_long)	psi-mi:orp3a_arath(display_long)|uniprotkb:UNE18(gene name synonym)|uniprotkb:OSBP-related protein 3A(gene name synonym)|uniprotkb:Protein UNFERTILIZED EMBRYO SAC 18(gene name synonym)|uniprotkb:T7H20.150(orf name)|uniprotkb:ORP3A(gene name)|psi-mi:ORP3A(display_short)|uniprotkb:At5g02100(locus name)	psi-mi:"MI:0001"(interaction detection method)	Saravanan et al. (2009)	pubmed:19207211|imex:IM-19586	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:3702(arath)|taxid:3702("Arabidopsis thaliana (Mouse-ear cress)")	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2460670|imex:IM-19586-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	chebi:"CHEBI:27693"(sitosterol)	refseq:NP_195830.1|interpro:IPR000648(Oxysterol-binding protein)|interpro:IPR018494|interpro:IPR037239|ensemblplants:AT5G02100(gene)|ensemblplants:AT5G02100.1(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0009567"(double fertilization forming a zygote and endosperm)|go:"GO:0015248"(sterol transporter activity)|go:"GO:0016020"(membrane)|go:"GO:0032934"(sterol binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)	-	-	-	figure legend:Figure 7a|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/03/20	2014/10/16	-	rogid:soIZ7mZyykOXWs2PXif8Zq2U+WE3702	intact-crc:DFB4F8249A5DE1A8	false	-	his tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
intact:EBI-2460668	uniprotkb:Q9LZM1	-	intact:EBI-2292648|ensemblplants:AT5G02100.1	psi-mi:sitosterol(display_short)|psi-mi:EBI-2460668(display_long)	psi-mi:orp3a_arath(display_long)|uniprotkb:UNE18(gene name synonym)|uniprotkb:OSBP-related protein 3A(gene name synonym)|uniprotkb:Protein UNFERTILIZED EMBRYO SAC 18(gene name synonym)|uniprotkb:T7H20.150(orf name)|uniprotkb:ORP3A(gene name)|psi-mi:ORP3A(display_short)|uniprotkb:At5g02100(locus name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Saravanan et al. (2009)	pubmed:19207211|imex:IM-19586	taxid:-2(chemical synthesis)|taxid:-2("Chemical synthesis (Chemical synthesis)")	taxid:3702(arath)|taxid:3702("Arabidopsis thaliana (Mouse-ear cress)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2460687|imex:IM-19586-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0328"(small molecule)	psi-mi:"MI:0326"(protein)	chebi:"CHEBI:27693"(sitosterol)	refseq:NP_195830.1|interpro:IPR000648(Oxysterol-binding protein)|interpro:IPR018494|interpro:IPR037239|ensemblplants:AT5G02100(gene)|ensemblplants:AT5G02100.1(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0009567"(double fertilization forming a zygote and endosperm)|go:"GO:0015248"(sterol transporter activity)|go:"GO:0016020"(membrane)|go:"GO:0032934"(sterol binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)	-	-	-	figure legend:Figure 7b Figure 7c|comment:Sitosterol was labelled with tritium isotope.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/03/20	2014/10/16	-	rogid:soIZ7mZyykOXWs2PXif8Zq2U+WE3702	intact-crc:9B0AFD6E4A6BED12	false	-	his tag:?-?	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)