#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P15927	uniprotkb:P04489	intact:EBI-621404|ensembl:ENSP00000363021|uniprotkb:Q52II0|uniprotkb:Q5TEI9|uniprotkb:Q5TEJ5	intact:EBI-6398911	psi-mi:rfa2_human(display_long)|uniprotkb:RPA34(gene name synonym)|uniprotkb:Replication protein A 34 kDa subunit(gene name synonym)|uniprotkb:Replication factor A protein 2(gene name synonym)|uniprotkb:RPA2(gene name)|psi-mi:RPA2(display_short)|uniprotkb:REPA2(gene name synonym)|uniprotkb:RPA32(gene name synonym)	psi-mi:e411_ade05(display_long)	psi-mi:"MI:0416"(fluorescence microscopy)	Carson et al. (2009)	pubmed:19197236|imex:IM-13865|mint:MINT-7114538|doi:10.1038/emboj.2009.15	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:28285(ade05)|taxid:28285("Human adenovirus C serotype 5 (HAdV-5)")	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-8561880|mint:MINT-7114674|imex:IM-13865-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:1L1O|rcsb pdb:1QUQ|rcsb pdb:1Z1D|rcsb pdb:2PI2|rcsb pdb:2PQA|rcsb pdb:2Z6K|rcsb pdb:3KDF|rcsb pdb:4MQV|rcsb pdb:4OU0|reactome:R-HSA-110312|reactome:R-HSA-110314|reactome:R-HSA-110320|reactome:R-HSA-174437|reactome:R-HSA-176187|reactome:R-HSA-3371453|reactome:R-HSA-3371511|reactome:R-HSA-5358565|reactome:R-HSA-5358606|reactome:R-HSA-5651801|reactome:R-HSA-5655862|reactome:R-HSA-5656121|reactome:R-HSA-5656169|reactome:R-HSA-5685938|reactome:R-HSA-5685942|reactome:R-HSA-5693607|reactome:R-HSA-5693616|reactome:R-HSA-5696395|reactome:R-HSA-5696397|reactome:R-HSA-5696400|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6783310|reactome:R-HSA-6804756|reactome:R-HSA-68962|reactome:R-HSA-69166|reactome:R-HSA-69473|reactome:R-HSA-912446|rcsb pdb:1DPU|ensembl:ENSG00000117748(gene)|ensembl:ENST00000373912(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005662"(DNA replication factor A complex)|go:"GO:0006260"(DNA replication)|go:"GO:0006284"(base-excision repair)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006298"(mismatch repair)|go:"GO:0010569"(regulation of double-strand break repair via homologous recombination)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0019899"(enzyme binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034502"(protein localization to chromosome)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0098505"(G-rich strand telomeric DNA binding)|go:"GO:2000001"(regulation of DNA damage checkpoint)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR014646(Replication protein A, subunit RPA32)|interpro:IPR014892(Replication protein A C terminal)|interpro:IPR036388|interpro:IPR036390|interpro:IPR040260|mint:P15927|refseq:NP_001273005.1|refseq:NP_002937.1|refseq:NP_001284487.1|dip:DIP-24187N|mint:MINT-7114677(identity)	go:"GO:0042802"(identical protein binding)|interpro:IPR009699(Mastadenovirus E4 ORF3)|interpro:IPR038368|rcsb pdb:4DJB|mint:P04489|refseq:AP_000230.1|dip:DIP-571N|mint:MINT-7114676(identity)	go:"GO:0019034"(viral replication complex)	-	-	figure legend:f3a|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2009/05/26	2014/10/16	rogid:+Ute8Lq5hnN0sLAQNWZb0cAbcTI9606	rogid:QrVWoDINatBHpKYrEh2vSgBLB4c28285	intact-crc:D0C54E2CD51E1C39|rigid:k0W1ATClXNvIxmd0uf75omun5po	false	-	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:P15927	uniprotkb:P03265	intact:EBI-621404|ensembl:ENSP00000363021|uniprotkb:Q52II0|uniprotkb:Q5TEI9|uniprotkb:Q5TEJ5	intact:EBI-7322567|intact:MINT-216016	psi-mi:rfa2_human(display_long)|uniprotkb:RPA34(gene name synonym)|uniprotkb:Replication protein A 34 kDa subunit(gene name synonym)|uniprotkb:Replication factor A protein 2(gene name synonym)|uniprotkb:RPA2(gene name)|psi-mi:RPA2(display_short)|uniprotkb:REPA2(gene name synonym)|uniprotkb:RPA32(gene name synonym)	psi-mi:dnb2_ade05(display_long)|uniprotkb:DBP(gene name)|psi-mi:DBP(display_short)|uniprotkb:Early 2A protein(gene name synonym)|uniprotkb:Early E2A DNA-binding protein(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Carson et al. (2009)	pubmed:19197236|imex:IM-13865|mint:MINT-7114538|doi:10.1038/emboj.2009.15	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:28285(ade05)|taxid:28285("Human adenovirus C serotype 5 (HAdV-5)")	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-8561946|mint:MINT-7114844|imex:IM-13865-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rcsb pdb:1L1O|rcsb pdb:1QUQ|rcsb pdb:1Z1D|rcsb pdb:2PI2|rcsb pdb:2PQA|rcsb pdb:2Z6K|rcsb pdb:3KDF|rcsb pdb:4MQV|rcsb pdb:4OU0|reactome:R-HSA-110312|reactome:R-HSA-110314|reactome:R-HSA-110320|reactome:R-HSA-174437|reactome:R-HSA-176187|reactome:R-HSA-3371453|reactome:R-HSA-3371511|reactome:R-HSA-5358565|reactome:R-HSA-5358606|reactome:R-HSA-5651801|reactome:R-HSA-5655862|reactome:R-HSA-5656121|reactome:R-HSA-5656169|reactome:R-HSA-5685938|reactome:R-HSA-5685942|reactome:R-HSA-5693607|reactome:R-HSA-5693616|reactome:R-HSA-5696395|reactome:R-HSA-5696397|reactome:R-HSA-5696400|reactome:R-HSA-6782135|reactome:R-HSA-6782210|reactome:R-HSA-6783310|reactome:R-HSA-6804756|reactome:R-HSA-68962|reactome:R-HSA-69166|reactome:R-HSA-69473|reactome:R-HSA-912446|rcsb pdb:1DPU|ensembl:ENSG00000117748(gene)|ensembl:ENST00000373912(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005662"(DNA replication factor A complex)|go:"GO:0006260"(DNA replication)|go:"GO:0006284"(base-excision repair)|go:"GO:0006289"(nucleotide-excision repair)|go:"GO:0006298"(mismatch repair)|go:"GO:0010569"(regulation of double-strand break repair via homologous recombination)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0019899"(enzyme binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0031571"(mitotic G1 DNA damage checkpoint signaling)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034502"(protein localization to chromosome)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0098505"(G-rich strand telomeric DNA binding)|go:"GO:2000001"(regulation of DNA damage checkpoint)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR014646(Replication protein A, subunit RPA32)|interpro:IPR014892(Replication protein A C terminal)|interpro:IPR036388|interpro:IPR036390|interpro:IPR040260|mint:P15927|refseq:NP_001273005.1|refseq:NP_002937.1|refseq:NP_001284487.1|dip:DIP-24187N|mint:MINT-7114847(identity)	mint:P03265|refseq:AP_000213.1|go:"GO:0003677"(DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0008270"(zinc ion binding)|go:"GO:0019028"(viral capsid)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0039687"(viral DNA strand displacement replication)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0045740"(positive regulation of DNA replication)|rcsb pdb:1ADU|rcsb pdb:1ADV|rcsb pdb:1ANV|rcsb pdb:2WAZ|rcsb pdb:2WB0|interpro:IPR003176(Viral DNA-binding protein)|interpro:IPR005376(Early E2A, DNA and zinc binding)|interpro:IPR036362|interpro:IPR036367|interpro:IPR036368|interpro:IPR037540|mint:MINT-7114849(identity)	go:"GO:0019034"(viral replication complex)	-	function:Binds cooperatively single-stranded DNA in a sequence-independent manner. Involved in DNA-replication, regulation of mRNA formation, and host-range specificity. Zinc is required for DNA binding|comment:mint	figure legend:f3|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2009/05/26	2014/10/16	rogid:+Ute8Lq5hnN0sLAQNWZb0cAbcTI9606	rogid:mhqOeQsoyUQ1xu2MGWfHN8d758o28285	intact-crc:8C822FE8982575D5|rigid:kimvVShOG4VfD2G2w+7SG0uP3eI	false	-	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:P03265	uniprotkb:Q8WXE1	intact:EBI-7322567|intact:MINT-216016	intact:EBI-747353|uniprotkb:Q8NHQ2|uniprotkb:Q8WUG7|uniprotkb:Q96CL3|uniprotkb:Q9HA30|uniprotkb:A8K6A3|uniprotkb:A8K714|uniprotkb:B2RCE7|uniprotkb:Q69YK9|uniprotkb:B4DU92|uniprotkb:B5MEB7|ensembl:ENSP00000323099	psi-mi:dnb2_ade05(display_long)|uniprotkb:DBP(gene name)|psi-mi:DBP(display_short)|uniprotkb:Early 2A protein(gene name synonym)|uniprotkb:Early E2A DNA-binding protein(gene name synonym)	psi-mi:atrip_human(display_long)|uniprotkb:ATM and Rad3-related-interacting protein(gene name synonym)|uniprotkb:ATRIP(gene name)|psi-mi:ATRIP(display_short)|uniprotkb:AGS1(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Carson et al. (2009)	pubmed:19197236|imex:IM-13865|mint:MINT-7114538|doi:10.1038/emboj.2009.15	taxid:28285(ade05)|taxid:28285("Human adenovirus C serotype 5 (HAdV-5)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-8562002|mint:MINT-7115004|imex:IM-13865-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	mint:P03265|refseq:AP_000213.1|go:"GO:0003677"(DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0008270"(zinc ion binding)|go:"GO:0019028"(viral capsid)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0039687"(viral DNA strand displacement replication)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0045740"(positive regulation of DNA replication)|rcsb pdb:1ADU|rcsb pdb:1ADV|rcsb pdb:1ANV|rcsb pdb:2WAZ|rcsb pdb:2WB0|interpro:IPR003176(Viral DNA-binding protein)|interpro:IPR005376(Early E2A, DNA and zinc binding)|interpro:IPR036362|interpro:IPR036367|interpro:IPR036368|interpro:IPR037540|mint:MINT-7115009(identity)	refseq:NP_115542.2|refseq:NP_569055.1|dip:DIP-46495N|refseq:NP_001257951.1|refseq:NP_001257952.1|ensembl:ENSG00000164053(gene)|ensembl:ENST00000320211(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|interpro:IPR033349|mint:Q8WXE1|rcsb pdb:4IGK|rcsb pdb:4NB3|rcsb pdb:5YZ0|reactome:R-HSA-176187|reactome:R-HSA-5685938|reactome:R-HSA-5693607|reactome:R-HSA-5693616|reactome:R-HSA-6783310|reactome:R-HSA-6804756|reactome:R-HSA-69473|mint:MINT-7115007(identity)	go:"GO:0019034"(viral replication complex)	function:Binds cooperatively single-stranded DNA in a sequence-independent manner. Involved in DNA-replication, regulation of mRNA formation, and host-range specificity. Zinc is required for DNA binding|comment:mint	-	figure legend:f3|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2009/05/26	2014/10/16	rogid:mhqOeQsoyUQ1xu2MGWfHN8d758o28285	rogid:VVllxHySIT6EGlT6SQhPePAXbsI9606	intact-crc:D798B89EF0EC9178|rigid:F3Tpq8azA7/tI6XwKqRkCpCe+qU	false	-	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:P03265	uniprotkb:Q92547	intact:EBI-7322567|intact:MINT-216016	intact:EBI-308302|uniprotkb:Q7LGC1|uniprotkb:Q9UEB9|uniprotkb:B7Z7W8|ensembl:ENSP00000260810	psi-mi:dnb2_ade05(display_long)|uniprotkb:DBP(gene name)|psi-mi:DBP(display_short)|uniprotkb:Early 2A protein(gene name synonym)|uniprotkb:Early E2A DNA-binding protein(gene name synonym)	psi-mi:topb1_human(display_long)|uniprotkb:KIAA0259(gene name synonym)|uniprotkb:TOPBP1(gene name)|psi-mi:TOPBP1(display_short)|uniprotkb:DNA topoisomerase II-binding protein 1(gene name synonym)|uniprotkb:DNA topoisomerase II-beta-binding protein 1(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Carson et al. (2009)	pubmed:19197236|imex:IM-13865|mint:MINT-7114538|doi:10.1038/emboj.2009.15	taxid:28285(ade05)|taxid:28285("Human adenovirus C serotype 5 (HAdV-5)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-8561974|mint:MINT-7114957|imex:IM-13865-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	mint:P03265|refseq:AP_000213.1|go:"GO:0003677"(DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0008270"(zinc ion binding)|go:"GO:0019028"(viral capsid)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0039687"(viral DNA strand displacement replication)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0045740"(positive regulation of DNA replication)|rcsb pdb:1ADU|rcsb pdb:1ADV|rcsb pdb:1ANV|rcsb pdb:2WAZ|rcsb pdb:2WB0|interpro:IPR003176(Viral DNA-binding protein)|interpro:IPR005376(Early E2A, DNA and zinc binding)|interpro:IPR036362|interpro:IPR036367|interpro:IPR036368|interpro:IPR037540|mint:MINT-7114960(identity)	refseq:NP_008958.2|ensembl:ENSG00000163781(gene)|ensembl:ENST00000260810(transcript)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0000922"(spindle pole)|go:"GO:0001673"(male germ cell nucleus)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005886"(plasma membrane)|go:"GO:0006259"(DNA metabolic process)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0033314"(mitotic DNA replication checkpoint signaling)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR001357(BRCT)|interpro:IPR035960|interpro:IPR036420|interpro:IPR044737|mint:Q92547|rcsb pdb:1WF6|rcsb pdb:2XNH|rcsb pdb:2XNK|rcsb pdb:3AL2|rcsb pdb:3AL3|rcsb pdb:3JVE|rcsb pdb:3OLC|rcsb pdb:3PD7|rcsb pdb:3UEN|rcsb pdb:3UEO|rcsb pdb:6RML|rcsb pdb:6RMM|rcsb pdb:7CMZ|reactome:R-HSA-5685938|reactome:R-HSA-5693607|reactome:R-HSA-5693616|reactome:R-HSA-6804756|reactome:R-HSA-69473|refseq:XP_016861125.1|dip:DIP-24263N|mint:MINT-7114962(identity)	go:"GO:0019034"(viral replication complex)	function:Binds cooperatively single-stranded DNA in a sequence-independent manner. Involved in DNA-replication, regulation of mRNA formation, and host-range specificity. Zinc is required for DNA binding|comment:mint	-	figure legend:f3|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2009/05/26	2014/10/16	rogid:mhqOeQsoyUQ1xu2MGWfHN8d758o28285	rogid:QlPHW0dd/u8bQgAUNVnsjcsO+Bk9606	intact-crc:0BC4FB63E2A422A9|rigid:+Z0EwWB6QYMpTdpQ1PG2WaRtaDQ	false	-	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:Q92878	uniprotkb:P49959	intact:EBI-495494|uniprotkb:O43254|uniprotkb:Q6GMT7|uniprotkb:Q6P5X3|uniprotkb:Q9UP86|uniprotkb:B9EGF5|ensembl:ENSP00000368100	intact:EBI-396513|uniprotkb:O43475|uniprotkb:B3KTC7|ensembl:ENSP00000325863	psi-mi:rad50_human(display_long)|uniprotkb:RAD50(gene name)|psi-mi:RAD50(display_short)	psi-mi:mre11_human(display_long)|uniprotkb:MRE11(gene name)|psi-mi:MRE11(display_short)|uniprotkb:Double-strand break repair protein MRE11A(gene name synonym)|uniprotkb:HNGS1(gene name synonym)|uniprotkb:MRE11A(gene name synonym)|uniprotkb:Meiotic recombination 11 homolog 1(gene name synonym)|uniprotkb:Meiotic recombination 11 homolog A(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Carson et al. (2009)	pubmed:19197236|imex:IM-13865|mint:MINT-7114538|doi:10.1038/emboj.2009.15	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-8562030|mint:MINT-7231003|imex:IM-13865-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005723.2|dip:DIP-33606N|ensembl:ENSG00000113522(gene)|ensembl:ENST00000378823(transcript)|go:"GO:0000019"(regulation of mitotic recombination)|go:"GO:0000722"(telomere maintenance via recombination)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0003677"(DNA binding)|go:"GO:0003691"(double-stranded telomeric DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0016020"(membrane)|go:"GO:0016787"(hydrolase activity)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030870"(Mre11 complex)|go:"GO:0031860"(telomeric 3' overhang formation)|go:"GO:0031954"(positive regulation of protein autophosphorylation)|go:"GO:0032206"(positive regulation of telomere maintenance)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042802"(identical protein binding)|go:"GO:0043047"(single-stranded telomeric DNA binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051880"(G-quadruplex DNA binding)|go:"GO:0070192"(chromosome organization involved in meiotic cell cycle)|go:"GO:0090305"(nucleic acid phosphodiester bond hydrolysis)|go:"GO:1904354"(negative regulation of telomere capping)|interpro:IPR013134(Zinc hook, Rad50)|interpro:IPR027417|interpro:IPR038729|mint:Q92878|rcsb pdb:5GOX|reactome:R-HSA-2559586|reactome:R-HSA-5685938|reactome:R-HSA-5685939|reactome:R-HSA-5685942|reactome:R-HSA-5693548|reactome:R-HSA-5693554|reactome:R-HSA-5693565|reactome:R-HSA-5693568|reactome:R-HSA-5693571|reactome:R-HSA-5693579|reactome:R-HSA-5693607|reactome:R-HSA-5693616|reactome:R-HSA-6804756|reactome:R-HSA-69473|reactome:R-HSA-912446|interpro:IPR004584(Recombination/repair protein Rad50)|mint:MINT-7231008(identity)	refseq:NP_005581.2|refseq:NP_005582.1|refseq:XP_011541139.1|refseq:XP_016873261.1|dip:DIP-33238N|ensembl:ENSG00000020922(gene)|ensembl:ENST00000323929(transcript)|go:"GO:0000014"(single-stranded DNA endodeoxyribonuclease activity)|go:"GO:0000019"(regulation of mitotic recombination)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0004518"(nuclease activity)|go:"GO:0004520"(endodeoxyribonuclease activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006310"(DNA recombination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0007062"(sister chromatid cohesion)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0007129"(homologous chromosome pairing at meiosis)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008296"(3'-5'-exodeoxyribonuclease activity)|go:"GO:0008408"(3'-5' exonuclease activity)|go:"GO:0008409"(5'-3' exonuclease activity)|go:"GO:0016605"(PML body)|go:"GO:0030145"(manganese ion binding)|go:"GO:0030870"(Mre11 complex)|go:"GO:0031573"(mitotic intra-S DNA damage checkpoint signaling)|go:"GO:0031860"(telomeric 3' overhang formation)|go:"GO:0031954"(positive regulation of protein autophosphorylation)|go:"GO:0032206"(positive regulation of telomere maintenance)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042138"(meiotic DNA double-strand break formation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045296"(cadherin binding)|go:"GO:0097552"(mitochondrial double-strand break repair via homologous recombination)|go:"GO:0110025"(DNA strand resection involved in replication fork processing)|interpro:IPR003701(DNA repair exonuclease)|interpro:IPR004843(Metallophosphoesterase)|interpro:IPR007281(Mre11, DNA-binding)|interpro:IPR029052|interpro:IPR038487|interpro:IPR041796|mint:P49959|rcsb pdb:3T1I|reactome:R-HSA-1834949|reactome:R-HSA-2559586|reactome:R-HSA-3270619|reactome:R-HSA-5685938|reactome:R-HSA-5685939|reactome:R-HSA-5685942|reactome:R-HSA-5693548|reactome:R-HSA-5693554|reactome:R-HSA-5693565|reactome:R-HSA-5693568|reactome:R-HSA-5693571|reactome:R-HSA-5693579|reactome:R-HSA-5693607|reactome:R-HSA-5693616|reactome:R-HSA-6804756|reactome:R-HSA-69473|reactome:R-HSA-912446|mint:MINT-7231006(identity)	-	-	-	figure legend:f6a|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2009/05/26	2014/10/16	rogid:yZsT5GcpA9HeFMoK4Jb1HYhrdKQ9606	rogid:fgwgA0BcNZ9phGBaOSYjkldDgeI9606	intact-crc:7AC2FAB1034459EA|rigid:+2H6IosKMi/mNU8lKGmr8CIvy8s	false	-	yellow fluorescent protein tag:?-?(MINT-7231014)	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:P03265	uniprotkb:Q13535	intact:EBI-7322567|intact:MINT-216016	intact:EBI-968983|ensembl:ENSP00000343741|uniprotkb:Q7KYL3|uniprotkb:Q93051|uniprotkb:Q9BXK4|uniprotkb:Q59HB2	psi-mi:dnb2_ade05(display_long)|uniprotkb:DBP(gene name)|psi-mi:DBP(display_short)|uniprotkb:Early 2A protein(gene name synonym)|uniprotkb:Early E2A DNA-binding protein(gene name synonym)	psi-mi:atr_human(display_long)|uniprotkb:ATR(gene name)|psi-mi:ATR(display_short)|uniprotkb:FRP1(gene name synonym)|uniprotkb:Ataxia telangiectasia and Rad3-related protein(gene name synonym)|uniprotkb:FRAP-related protein 1(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Carson et al. (2009)	pubmed:19197236|imex:IM-13865|mint:MINT-7114538|doi:10.1038/emboj.2009.15	taxid:28285(ade05)|taxid:28285("Human adenovirus C serotype 5 (HAdV-5)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-8562016|mint:MINT-7115097|imex:IM-13865-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	mint:P03265|refseq:AP_000213.1|go:"GO:0003677"(DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0008270"(zinc ion binding)|go:"GO:0019028"(viral capsid)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0039687"(viral DNA strand displacement replication)|go:"GO:0039693"(viral DNA genome replication)|go:"GO:0042025"(host cell nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0045740"(positive regulation of DNA replication)|rcsb pdb:1ADU|rcsb pdb:1ADV|rcsb pdb:1ANV|rcsb pdb:2WAZ|rcsb pdb:2WB0|interpro:IPR003176(Viral DNA-binding protein)|interpro:IPR005376(Early E2A, DNA and zinc binding)|interpro:IPR036362|interpro:IPR036367|interpro:IPR036368|interpro:IPR037540|mint:MINT-7115102(identity)	ensembl:ENSG00000175054(gene)|ensembl:ENST00000350721(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000723"(telomere maintenance)|go:"GO:0003677"(DNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006260"(DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007275"(multicellular organism development)|go:"GO:0008156"(negative regulation of DNA replication)|go:"GO:0016605"(PML body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0031297"(replication fork processing)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032405"(MutLalpha complex binding)|go:"GO:0032407"(MutSalpha complex binding)|go:"GO:0034644"(cellular response to UV)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0042493"|go:"GO:0043517"(positive regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0070198"(protein localization to chromosome, telomeric region)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0090399"(replicative senescence)|go:"GO:0097694"(establishment of RNA localization to telomere)|go:"GO:0097695"(establishment of protein-containing complex localization to telomere)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900034"(regulation of cellular response to heat)|go:"GO:1904884"(positive regulation of telomerase catalytic core complex assembly)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR003151(PIK-related kinase, FAT)|interpro:IPR003152(PIK-related kinase, FATC)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR012993(UME)|interpro:IPR014009(PIK-related kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR021133|interpro:IPR036940|mint:Q13535|rcsb pdb:5YZ0|reactome:R-HSA-1221632|reactome:R-HSA-176187|reactome:R-HSA-3371453|reactome:R-HSA-5685938|reactome:R-HSA-5693607|reactome:R-HSA-5693616|reactome:R-HSA-6783310|reactome:R-HSA-6796648|reactome:R-HSA-6804756|reactome:R-HSA-69473|refseq:NP_001175.2|refseq:XP_016862132.1|dip:DIP-35308N|mint:MINT-7115100(identity)	go:"GO:0019034"(viral replication complex)	function:Binds cooperatively single-stranded DNA in a sequence-independent manner. Involved in DNA-replication, regulation of mRNA formation, and host-range specificity. Zinc is required for DNA binding|comment:mint	-	figure legend:f3|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2009/05/26	2014/10/16	rogid:mhqOeQsoyUQ1xu2MGWfHN8d758o28285	rogid:ZYzDNmnxcK+RJN42KfgQZlxGACU9606	intact-crc:ADF46F621D2698DB|rigid:EVsEAmCEmClZYPS1YsyLeq3WOCY	false	-	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:Q92878	uniprotkb:O60934	intact:EBI-495494|uniprotkb:O43254|uniprotkb:Q6GMT7|uniprotkb:Q6P5X3|uniprotkb:Q9UP86|uniprotkb:B9EGF5|ensembl:ENSP00000368100	intact:EBI-494844|uniprotkb:O60672|uniprotkb:Q32NF7|uniprotkb:Q53FM6|uniprotkb:Q63HR6|uniprotkb:Q7LDM2|uniprotkb:B2R626|uniprotkb:B2RNC5|ensembl:ENSP00000265433	psi-mi:rad50_human(display_long)|uniprotkb:RAD50(gene name)|psi-mi:RAD50(display_short)	psi-mi:nbn_human(display_long)|uniprotkb:Nijmegen breakage syndrome protein 1(gene name synonym)|uniprotkb:Cell cycle regulatory protein p95(gene name synonym)|uniprotkb:NBN(gene name)|psi-mi:NBN(display_short)|uniprotkb:NBS1(gene name synonym)|uniprotkb:NBS(gene name synonym)|uniprotkb:P95(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Carson et al. (2009)	pubmed:19197236|imex:IM-13865|mint:MINT-7114538|doi:10.1038/emboj.2009.15	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-8562045|mint:MINT-7231018|imex:IM-13865-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005723.2|dip:DIP-33606N|ensembl:ENSG00000113522(gene)|ensembl:ENST00000378823(transcript)|go:"GO:0000019"(regulation of mitotic recombination)|go:"GO:0000722"(telomere maintenance via recombination)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0003677"(DNA binding)|go:"GO:0003691"(double-stranded telomeric DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006310"(DNA recombination)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0007131"(reciprocal meiotic recombination)|go:"GO:0016020"(membrane)|go:"GO:0016787"(hydrolase activity)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030870"(Mre11 complex)|go:"GO:0031860"(telomeric 3' overhang formation)|go:"GO:0031954"(positive regulation of protein autophosphorylation)|go:"GO:0032206"(positive regulation of telomere maintenance)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042802"(identical protein binding)|go:"GO:0043047"(single-stranded telomeric DNA binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051880"(G-quadruplex DNA binding)|go:"GO:0070192"(chromosome organization involved in meiotic cell cycle)|go:"GO:0090305"(nucleic acid phosphodiester bond hydrolysis)|go:"GO:1904354"(negative regulation of telomere capping)|interpro:IPR013134(Zinc hook, Rad50)|interpro:IPR027417|interpro:IPR038729|mint:Q92878|rcsb pdb:5GOX|reactome:R-HSA-2559586|reactome:R-HSA-5685938|reactome:R-HSA-5685939|reactome:R-HSA-5685942|reactome:R-HSA-5693548|reactome:R-HSA-5693554|reactome:R-HSA-5693565|reactome:R-HSA-5693568|reactome:R-HSA-5693571|reactome:R-HSA-5693579|reactome:R-HSA-5693607|reactome:R-HSA-5693616|reactome:R-HSA-6804756|reactome:R-HSA-69473|reactome:R-HSA-912446|interpro:IPR004584(Recombination/repair protein Rad50)|mint:MINT-7231021(identity)	refseq:NP_002476.2|refseq:NP_001019859.1|refseq:XP_011515347.1|dip:DIP-33605N|ensembl:ENSG00000104320(gene)|ensembl:ENST00000265433(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0001832"(blastocyst growth)|go:"GO:0003684"(damaged DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005657"(replication fork)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006302"(double-strand break repair)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016605"(PML body)|go:"GO:0030174"(regulation of DNA-dependent DNA replication initiation)|go:"GO:0030330"(DNA damage response, signal transduction by p53 class mediator)|go:"GO:0030870"(Mre11 complex)|go:"GO:0031860"(telomeric 3' overhang formation)|go:"GO:0031954"(positive regulation of protein autophosphorylation)|go:"GO:0032206"(positive regulation of telomere maintenance)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042405"(nuclear inclusion body)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0045190"(isotype switching)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0090656"(t-circle formation)|go:"GO:0090737"(telomere maintenance via telomere trimming)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1904354"(negative regulation of telomere capping)|interpro:IPR000253(Forkhead-associated)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR013908(DNA  repair Nbs1, C-terminal)|interpro:IPR016592(Nibrin)|interpro:IPR032429|interpro:IPR036420|interpro:IPR040227|interpro:IPR043014|mint:O60934|rcsb pdb:5WQD|reactome:R-HSA-2559586|reactome:R-HSA-5685938|reactome:R-HSA-5685939|reactome:R-HSA-5685942|reactome:R-HSA-5693548|reactome:R-HSA-5693554|reactome:R-HSA-5693565|reactome:R-HSA-5693568|reactome:R-HSA-5693571|reactome:R-HSA-6804756|reactome:R-HSA-69473|reactome:R-HSA-912446|reactome:R-HSA-5693579|reactome:R-HSA-5693607|reactome:R-HSA-5693616|mint:MINT-7231023(identity)	-	-	-	figure legend:f6a|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2009/05/26	2014/10/16	rogid:yZsT5GcpA9HeFMoK4Jb1HYhrdKQ9606	rogid:CTx61/3iHRb2kWfb5u/CSye5A2k9606	intact-crc:5E21584240745F21|rigid:JqZ/85kGNJE79wcLNVg5YrUi84E	false	-	yellow fluorescent protein tag:?-?(MINT-7231024)	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)