#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P26012	uniprotkb:P06756	intact:EBI-2436381|uniprotkb:B4DHD4|uniprotkb:A4D133|ensembl:ENSP00000222573	intact:EBI-298282|ensembl:ENSP00000261023|uniprotkb:A0AV67|uniprotkb:Q53SK4|uniprotkb:Q59EB7|uniprotkb:Q6LD15|uniprotkb:D3DPG8|intact:EBI-10984285|uniprotkb:B0LPF4|uniprotkb:B7Z883|uniprotkb:E7EWZ6|uniprotkb:B7ZLX0	psi-mi:itb8_human(display_long)|uniprotkb:ITGB8(gene name)|psi-mi:ITGB8(display_short)	psi-mi:itav_human(display_long)|uniprotkb:ITGAV(gene name)|psi-mi:ITGAV(display_short)|uniprotkb:VNRA(gene name synonym)|uniprotkb:Vitronectin receptor subunit alpha(gene name synonym)|uniprotkb:MSK8(gene name synonym)|uniprotkb:Vitronectin receptor(gene name synonym)|uniprotkb:VTNR(gene name synonym)	psi-mi:"MI:0019"(coimmunoprecipitation)	Moyle et al. (1991)	pubmed:1918072|imex:IM-20373	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2436404|imex:IM-20373-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_002205.1|refseq:XP_011513698.1|refseq:XP_016867667.1|refseq:XP_016867668.1|refseq:XP_016867669.1|refseq:XP_016867670.1|refseq:XP_016867671.1|refseq:XP_016867672.1|ensembl:ENSG00000105855(gene)|ensembl:ENST00000222573(transcript)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001573"(ganglioside metabolic process)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006955"(immune response)|go:"GO:0007155"(cell adhesion)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008305"(integrin complex)|go:"GO:0009615"(response to virus)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016477"(cell migration)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0034686"(integrin alphav-beta8 complex)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0051216"(cartilage development)|go:"GO:0060022"(hard palate development)|go:"GO:0060674"(placenta blood vessel development)|go:"GO:0061520"(Langerhans cell differentiation)|go:"GO:0070062"(extracellular exosome)|go:"GO:1901388"(regulation of transforming growth factor beta activation)|go:"GO:1990430"(extracellular matrix protein binding)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR002369(Integrin beta subunit, N-terminal)|interpro:IPR013111(EGF, extracellular)|interpro:IPR015442(Integrin beta-8 subunit-like, C-terminal)|interpro:IPR015812(Integrin beta subunit)|interpro:IPR016201(Plexin-like fold)|interpro:IPR032695|interpro:IPR033760|interpro:IPR036465|mint:P26012|rcsb pdb:6DJP|rcsb pdb:6OM1|rcsb pdb:6OM2|rcsb pdb:6UJA|rcsb pdb:6UJB|rcsb pdb:6UJC|reactome:R-HSA-2129379|reactome:R-HSA-216083	ensembl:ENSG00000138448(gene)|ensembl:ENST00000261023(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001618"(virus receptor activity)|go:"GO:0001846"(opsonin binding)|go:"GO:0001968"(fibronectin binding)|go:"GO:0002020"(protease binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008305"(integrin complex)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0009986"(cell surface)|go:"GO:0010745"(negative regulation of macrophage derived foam cell differentiation)|go:"GO:0010888"(negative regulation of lipid storage)|go:"GO:0015026"(coreceptor activity)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:1990430"(extracellular matrix protein binding)|go:"GO:2000536"(negative regulation of entry of bacterium into host cell)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000413(Integrins alpha chain)|interpro:IPR013517(FG-GAP)|interpro:IPR013519(Integrin alpha beta-propellor)|interpro:IPR013649(Integrin alpha-2)|interpro:IPR018184|interpro:IPR028994|interpro:IPR032695|mint:P06756|rcsb pdb:1JV2|rcsb pdb:1L5G|rcsb pdb:1M1X|rcsb pdb:1U8C|rcsb pdb:3IJE|rcsb pdb:4G1E|rcsb pdb:4G1M|rcsb pdb:4MMX|rcsb pdb:4MMY|rcsb pdb:4MMZ|go:"GO:1905598"(negative regulation of low-density lipoprotein receptor activity)|rcsb pdb:4O02|rcsb pdb:4UM8|reactome:R-HSA-210990|reactome:R-HSA-2129379|reactome:R-HSA-216083|reactome:R-HSA-3000157|reactome:R-HSA-3000170|reactome:R-HSA-3000178|reactome:R-HSA-4420097|reactome:R-HSA-445144|reactome:R-HSA-6798695|rcsb pdb:5FFG|rcsb pdb:5FFO|rcsb pdb:5NEM|rcsb pdb:5NER|rcsb pdb:5NET|rcsb pdb:5NEU|rcsb pdb:6AVQ|rcsb pdb:6AVR|rcsb pdb:6AVU|rcsb pdb:6DJP|rcsb pdb:6MK0|rcsb pdb:6MSL|rcsb pdb:6MSU|rcsb pdb:6NAJ|rcsb pdb:6OM1|rcsb pdb:6OM2|rcsb pdb:6UJA|rcsb pdb:6UJB|rcsb pdb:4UM9|rcsb pdb:6UJC|reactome:R-HSA-1236973|reactome:R-HSA-1566948|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0031527"(filopodium membrane)|go:"GO:0031528"(microvillus membrane)|go:"GO:0031589"(cell-substrate adhesion)|go:"GO:0032369"(negative regulation of lipid transport)|go:"GO:0032587"(ruffle membrane)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0033690"(positive regulation of osteoblast proliferation)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0034683"(integrin alphav-beta3 complex)|go:"GO:0034684"(integrin alphav-beta5 complex)|go:"GO:0034685"(integrin alphav-beta6 complex)|go:"GO:0034686"(integrin alphav-beta8 complex)|go:"GO:0035579"(specific granule membrane)|go:"GO:0035866"(alphav-beta3 integrin-PKCalpha complex)|go:"GO:0035867"(alphav-beta3 integrin-IGF-1-IGF1R complex)|go:"GO:0035868"(alphav-beta3 integrin-HMGB1 complex)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0038027"(apolipoprotein A-I-mediated signaling pathway)|go:"GO:0043277"(apoptotic cell clearance)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0046718"(viral entry into host cell)|go:"GO:0046872"(metal ion binding)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0050748"(negative regulation of lipoprotein metabolic process)|go:"GO:0050764"(regulation of phagocytosis)|go:"GO:0050840"(extracellular matrix binding)|go:"GO:0050919"(negative chemotaxis)|go:"GO:0051057"(positive regulation of small GTPase mediated signal transduction)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071604"(transforming growth factor beta production)|go:"GO:0085017"(entry into host cell by a symbiont-containing vacuole)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:1901388"(regulation of transforming growth factor beta activation)|go:"GO:1902533"(positive regulation of intracellular signal transduction)|refseq:NP_001138472.1|refseq:NP_002201.1|refseq:NP_001138471.1|dip:DIP-31785N	-	-	-	figure legend:7|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2009/09/16	2014/10/16	rogid:41trbnfJvGDNNQQic07tyOZywtY9606	rogid:3XbANVuHd/2LJX6zckEV6xx09mY9606	intact-crc:54566DAFD8A793CB|rigid:zp93H/k7upUZTGFwkzYTr0WujFk	false	-	-	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)