#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q925Q9	uniprotkb:Q15811-2	intact:EBI-8020091|uniprotkb:Q9JKQ0|uniprotkb:Q9JLU9|uniprotkb:Q925R1|intact:MINT-4611781|uniprotkb:Q925R3|uniprotkb:Q925R0|uniprotkb:Q925R2|uniprotkb:Q9JKQ1	intact:EBI-8052395|intact:MINT-5228062|ensembl:ENSP00000370691	psi-mi:sh3k1_rat(display_long)|uniprotkb:Sh3kbp1(gene name)|psi-mi:Sh3kbp1(display_short)|uniprotkb:Ruk(gene name synonym)|uniprotkb:Seta(gene name synonym)|uniprotkb:SH3-containing, expressed in tumorigenic astrocytes(gene name synonym)|uniprotkb:Regulator of ubiquitous kinase(gene name synonym)	psi-mi:q15811-2(display_long)|uniprotkb:Short(isoform synonym)|uniprotkb:ITSN1(gene name)|psi-mi:ITSN1(display_short)|uniprotkb:ITSN(gene name synonym)|uniprotkb:SH3 domain-containing protein 1A(gene name synonym)|uniprotkb:SH3D1A(gene name synonym)|uniprotkb:SH3P17(gene name synonym)|uniprotkb:ITSN-s(isoform synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Nikolaienko et al. (2009)	pubmed:19166927|mint:MINT-7215312|doi:10.1016/j.cellsig.2009.01.013	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8555189|mint:MINT-7231619	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_017457655.1|refseq:XP_008771422.1|refseq:XP_008771423.1|refseq:XP_008771424.1|refseq:NP_445812.1|rgd:620904|refseq:XP_006256992.1|refseq:XP_006256993.1|mint:Q925Q9|interpro:IPR035770|interpro:IPR035771|interpro:IPR035772|interpro:IPR036028|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006897"(endocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007015"(actin filament organization)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016477"(cell migration)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043005"(neuron projection)|go:"GO:0045202"(synapse)|go:"GO:0050871"(positive regulation of B cell activation)|reactome:R-RNO-182971|interpro:IPR001452(Src homology-3)|reactome:R-RNO-6807004|reactome:R-RNO-8856825|reactome:R-RNO-8856828|reactome:R-RNO-8866376|reactome:R-RNO-983695|interpro:IPR028506|mint:MINT-7231622(identity)	intact:EBI-602041(isoform-parent)|uniprotkb:Q15811-2(isoform-parent)|ensembl:ENSG00000205726(gene)|ensembl:ENST00000381291(transcript)|mint:MINT-7231621(identity)	-	comment:mint|function:"Adapter protein involved in regulating diverse signal transduction pathways. Involved in the regulation of endocytosis and lysosomal degradation of ligand-induced receptor tyrosine kinases, including EGFR and MET/hepatocyte growth factor receptor, through a association with CBL and endophilins. The association with CBL, and thus the receptor internalization, may inhibited by an interaction with PDCD6IP and/or SPRY2. Involved in regulation of ligand-dependent endocytosis of the IgE receptor (By similarity). Attenuates phosphatidylinositol 3-kinase activity by interaction with its regulatory subunit. May be involved in regulation of cell adhesion; promotes the interaction between TTK2B and PDCD6IP. May be involved in the regulation of cellular stress response via the MAPK pathways through its interaction with MAP3K4. Is involved in modulation of tumor necrosis factor mediated apoptosis"	comment:mint	figure legend:f2|comment:homomint|comment:mint|curation depth:mimix curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2009/07/22	2014/10/16	rogid:yLY00TbO3JtvC2I6IjRsWptvGb810116	rogid:bMtKQd70oD+6vDzmxoAwp93SD6w9606	intact-crc:74ED835575D6AC3F|rigid:YDCE34lYRNyI5w3z2iKgsWVud2w	false	tag:?-?(MINT-7231625)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q925Q9	uniprotkb:Q15811-2	intact:EBI-8020091|uniprotkb:Q9JKQ0|uniprotkb:Q9JLU9|uniprotkb:Q925R1|intact:MINT-4611781|uniprotkb:Q925R3|uniprotkb:Q925R0|uniprotkb:Q925R2|uniprotkb:Q9JKQ1	intact:EBI-8052395|intact:MINT-5228062|ensembl:ENSP00000370691	psi-mi:sh3k1_rat(display_long)|uniprotkb:Sh3kbp1(gene name)|psi-mi:Sh3kbp1(display_short)|uniprotkb:Ruk(gene name synonym)|uniprotkb:Seta(gene name synonym)|uniprotkb:SH3-containing, expressed in tumorigenic astrocytes(gene name synonym)|uniprotkb:Regulator of ubiquitous kinase(gene name synonym)	psi-mi:q15811-2(display_long)|uniprotkb:Short(isoform synonym)|uniprotkb:ITSN1(gene name)|psi-mi:ITSN1(display_short)|uniprotkb:ITSN(gene name synonym)|uniprotkb:SH3 domain-containing protein 1A(gene name synonym)|uniprotkb:SH3D1A(gene name synonym)|uniprotkb:SH3P17(gene name synonym)|uniprotkb:ITSN-s(isoform synonym)	psi-mi:"MI:0096"(pull down)	Nikolaienko et al. (2009)	pubmed:19166927|mint:MINT-7215312|doi:10.1016/j.cellsig.2009.01.013	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8555214|mint:MINT-7231631	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_017457655.1|refseq:XP_008771422.1|refseq:XP_008771423.1|refseq:XP_008771424.1|refseq:NP_445812.1|rgd:620904|refseq:XP_006256992.1|refseq:XP_006256993.1|mint:Q925Q9|interpro:IPR035770|interpro:IPR035771|interpro:IPR035772|interpro:IPR036028|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006897"(endocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007015"(actin filament organization)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016477"(cell migration)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043005"(neuron projection)|go:"GO:0045202"(synapse)|go:"GO:0050871"(positive regulation of B cell activation)|reactome:R-RNO-182971|interpro:IPR001452(Src homology-3)|reactome:R-RNO-6807004|reactome:R-RNO-8856825|reactome:R-RNO-8856828|reactome:R-RNO-8866376|reactome:R-RNO-983695|interpro:IPR028506|mint:MINT-7231633(identity)	intact:EBI-602041(isoform-parent)|uniprotkb:Q15811-2(isoform-parent)|ensembl:ENSG00000205726(gene)|ensembl:ENST00000381291(transcript)|mint:MINT-7231637(identity)	-	comment:mint|function:"Adapter protein involved in regulating diverse signal transduction pathways. Involved in the regulation of endocytosis and lysosomal degradation of ligand-induced receptor tyrosine kinases, including EGFR and MET/hepatocyte growth factor receptor, through a association with CBL and endophilins. The association with CBL, and thus the receptor internalization, may inhibited by an interaction with PDCD6IP and/or SPRY2. Involved in regulation of ligand-dependent endocytosis of the IgE receptor (By similarity). Attenuates phosphatidylinositol 3-kinase activity by interaction with its regulatory subunit. May be involved in regulation of cell adhesion; promotes the interaction between TTK2B and PDCD6IP. May be involved in the regulation of cellular stress response via the MAPK pathways through its interaction with MAP3K4. Is involved in modulation of tumor necrosis factor mediated apoptosis"	comment:mint	figure legend:f4a|comment:homomint|comment:mint|curation depth:mimix curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/07/22	2014/10/16	rogid:yLY00TbO3JtvC2I6IjRsWptvGb810116	rogid:bMtKQd70oD+6vDzmxoAwp93SD6w9606	intact-crc:BA6B92D48D94A78D|rigid:YDCE34lYRNyI5w3z2iKgsWVud2w	false	flag tag:?-?(MINT-7231634)	glutathione s tranferase tag:?-?(MINT-7231644)|binding-associated region:728-872(MINT-7231646)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q925Q9	uniprotkb:Q15811-2	intact:EBI-8020091|uniprotkb:Q9JKQ0|uniprotkb:Q9JLU9|uniprotkb:Q925R1|intact:MINT-4611781|uniprotkb:Q925R3|uniprotkb:Q925R0|uniprotkb:Q925R2|uniprotkb:Q9JKQ1	intact:EBI-8052395|intact:MINT-5228062|ensembl:ENSP00000370691	psi-mi:sh3k1_rat(display_long)|uniprotkb:Sh3kbp1(gene name)|psi-mi:Sh3kbp1(display_short)|uniprotkb:Ruk(gene name synonym)|uniprotkb:Seta(gene name synonym)|uniprotkb:SH3-containing, expressed in tumorigenic astrocytes(gene name synonym)|uniprotkb:Regulator of ubiquitous kinase(gene name synonym)	psi-mi:q15811-2(display_long)|uniprotkb:Short(isoform synonym)|uniprotkb:ITSN1(gene name)|psi-mi:ITSN1(display_short)|uniprotkb:ITSN(gene name synonym)|uniprotkb:SH3 domain-containing protein 1A(gene name synonym)|uniprotkb:SH3D1A(gene name synonym)|uniprotkb:SH3P17(gene name synonym)|uniprotkb:ITSN-s(isoform synonym)	psi-mi:"MI:0096"(pull down)	Nikolaienko et al. (2009)	pubmed:19166927|mint:MINT-7215312|doi:10.1016/j.cellsig.2009.01.013	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8555236|mint:MINT-7231651	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_017457655.1|refseq:XP_008771422.1|refseq:XP_008771423.1|refseq:XP_008771424.1|refseq:NP_445812.1|rgd:620904|refseq:XP_006256992.1|refseq:XP_006256993.1|mint:Q925Q9|interpro:IPR035770|interpro:IPR035771|interpro:IPR035772|interpro:IPR036028|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006897"(endocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007015"(actin filament organization)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016477"(cell migration)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043005"(neuron projection)|go:"GO:0045202"(synapse)|go:"GO:0050871"(positive regulation of B cell activation)|reactome:R-RNO-182971|interpro:IPR001452(Src homology-3)|reactome:R-RNO-6807004|reactome:R-RNO-8856825|reactome:R-RNO-8856828|reactome:R-RNO-8866376|reactome:R-RNO-983695|interpro:IPR028506|mint:MINT-7231660(identity)	intact:EBI-602041(isoform-parent)|uniprotkb:Q15811-2(isoform-parent)|ensembl:ENSG00000205726(gene)|ensembl:ENST00000381291(transcript)|mint:MINT-7231653(identity)	-	comment:mint|function:"Adapter protein involved in regulating diverse signal transduction pathways. Involved in the regulation of endocytosis and lysosomal degradation of ligand-induced receptor tyrosine kinases, including EGFR and MET/hepatocyte growth factor receptor, through a association with CBL and endophilins. The association with CBL, and thus the receptor internalization, may inhibited by an interaction with PDCD6IP and/or SPRY2. Involved in regulation of ligand-dependent endocytosis of the IgE receptor (By similarity). Attenuates phosphatidylinositol 3-kinase activity by interaction with its regulatory subunit. May be involved in regulation of cell adhesion; promotes the interaction between TTK2B and PDCD6IP. May be involved in the regulation of cellular stress response via the MAPK pathways through its interaction with MAP3K4. Is involved in modulation of tumor necrosis factor mediated apoptosis"	comment:mint	comment:homomint|comment:mint|figure legend:f4b f5a f5c|curation depth:mimix curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/07/22	2014/10/16	rogid:yLY00TbO3JtvC2I6IjRsWptvGb810116	rogid:bMtKQd70oD+6vDzmxoAwp93SD6w9606	intact-crc:4948171A5CE1638D|rigid:YDCE34lYRNyI5w3z2iKgsWVud2w	false	flag tag:?-?(MINT-7231661)|binding-associated region:328-709(MINT-7231666)	glutathione s tranferase tag:?-?(MINT-7231657)|binding-associated region:728-872,995-1068,?-?(MINT-7231654)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q15811-2	uniprotkb:Q925Q9	intact:EBI-8052395|intact:MINT-5228062|ensembl:ENSP00000370691	intact:EBI-8020091|uniprotkb:Q9JKQ0|uniprotkb:Q9JLU9|uniprotkb:Q925R1|intact:MINT-4611781|uniprotkb:Q925R3|uniprotkb:Q925R0|uniprotkb:Q925R2|uniprotkb:Q9JKQ1	psi-mi:q15811-2(display_long)|uniprotkb:Short(isoform synonym)|uniprotkb:ITSN1(gene name)|psi-mi:ITSN1(display_short)|uniprotkb:ITSN(gene name synonym)|uniprotkb:SH3 domain-containing protein 1A(gene name synonym)|uniprotkb:SH3D1A(gene name synonym)|uniprotkb:SH3P17(gene name synonym)|uniprotkb:ITSN-s(isoform synonym)	psi-mi:sh3k1_rat(display_long)|uniprotkb:Sh3kbp1(gene name)|psi-mi:Sh3kbp1(display_short)|uniprotkb:Ruk(gene name synonym)|uniprotkb:Seta(gene name synonym)|uniprotkb:SH3-containing, expressed in tumorigenic astrocytes(gene name synonym)|uniprotkb:Regulator of ubiquitous kinase(gene name synonym)	psi-mi:"MI:0096"(pull down)	Nikolaienko et al. (2009)	pubmed:19166927|mint:MINT-7215312|doi:10.1016/j.cellsig.2009.01.013	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8555266|mint:MINT-7231673	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-602041(isoform-parent)|uniprotkb:Q15811-2(isoform-parent)|ensembl:ENSG00000205726(gene)|ensembl:ENST00000381291(transcript)|mint:MINT-7231682(identity)	refseq:XP_017457655.1|refseq:XP_008771422.1|refseq:XP_008771423.1|refseq:XP_008771424.1|refseq:NP_445812.1|rgd:620904|refseq:XP_006256992.1|refseq:XP_006256993.1|mint:Q925Q9|interpro:IPR035770|interpro:IPR035771|interpro:IPR035772|interpro:IPR036028|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006897"(endocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007015"(actin filament organization)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016477"(cell migration)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043005"(neuron projection)|go:"GO:0045202"(synapse)|go:"GO:0050871"(positive regulation of B cell activation)|reactome:R-RNO-182971|interpro:IPR001452(Src homology-3)|reactome:R-RNO-6807004|reactome:R-RNO-8856825|reactome:R-RNO-8856828|reactome:R-RNO-8866376|reactome:R-RNO-983695|interpro:IPR028506|mint:MINT-7231675(identity)	-	comment:mint	comment:mint|function:"Adapter protein involved in regulating diverse signal transduction pathways. Involved in the regulation of endocytosis and lysosomal degradation of ligand-induced receptor tyrosine kinases, including EGFR and MET/hepatocyte growth factor receptor, through a association with CBL and endophilins. The association with CBL, and thus the receptor internalization, may inhibited by an interaction with PDCD6IP and/or SPRY2. Involved in regulation of ligand-dependent endocytosis of the IgE receptor (By similarity). Attenuates phosphatidylinositol 3-kinase activity by interaction with its regulatory subunit. May be involved in regulation of cell adhesion; promotes the interaction between TTK2B and PDCD6IP. May be involved in the regulation of cellular stress response via the MAPK pathways through its interaction with MAP3K4. Is involved in modulation of tumor necrosis factor mediated apoptosis"	figure legend:f5b|comment:homomint|comment:mint|curation depth:mimix curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/07/22	2014/10/16	rogid:bMtKQd70oD+6vDzmxoAwp93SD6w9606	rogid:yLY00TbO3JtvC2I6IjRsWptvGb810116	intact-crc:AAF4ABDC6B294592|rigid:YDCE34lYRNyI5w3z2iKgsWVud2w	false	glutathione s tranferase tag:?-?(MINT-7231683)|binding-associated region:728-872(MINT-7231685)	flag tag:?-?(MINT-7231679)|binding-associated region:440-450,462-469(MINT-7231676)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)