#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q8N6T7	uniprotkb:Q04206	intact:EBI-712415|ensembl:ENSP00000337332|uniprotkb:O75291|uniprotkb:Q6IAF5|uniprotkb:Q6PK99|uniprotkb:Q8NCD2|uniprotkb:Q9BSI5|uniprotkb:Q9BWP3|uniprotkb:Q9NRC7|uniprotkb:Q9UQD1|uniprotkb:B2RCD0	intact:EBI-73886|ensembl:ENSP00000384273|uniprotkb:Q6GTV1|uniprotkb:Q6SLK1	psi-mi:sir6_human(display_long)|uniprotkb:SIR2-like protein 6(gene name synonym)|uniprotkb:SIRT6(gene name)|psi-mi:SIRT6(display_short)|uniprotkb:SIR2L6(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 6(gene name synonym)	psi-mi:tf65_human(display_long)|uniprotkb:Nuclear factor NF-kappa-B p65 subunit(gene name synonym)|uniprotkb:RELA(gene name)|psi-mi:RELA(display_short)|uniprotkb:NFKB3(gene name synonym)|uniprotkb:Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kawahara et al. (2009)	imex:IM-12156|pubmed:19135889	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2213537|imex:IM-12156-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000077463(gene)|ensembl:ENST00000337491(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003247"(post-embryonic cardiac muscle cell growth involved in heart morphogenesis)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0003956"("NAD(P)+-protein-arginine ADP-ribosyltransferase activity")|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010569"(regulation of double-strand break repair via homologous recombination)|go:"GO:0017136"(NAD-dependent histone deacetylase activity)|go:"GO:0019213"(deacetylase activity)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0031940"(obsolete positive regulation of chromatin silencing at telomere)|go:"GO:0032206"(positive regulation of telomere maintenance)|go:"GO:0034979"(NAD-dependent protein deacetylase activity)|go:"GO:0046969"("NAD-dependent histone deacetylase activity (H3-K9 specific)")|go:"GO:0070403"(NAD+ binding)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0099115"(chromosome, subtelomeric region)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1901485"(positive regulation of transcription factor catabolic process)|go:"GO:1902732"(positive regulation of chondrocyte proliferation)|go:"GO:1905549"(obsolete positive regulation of subtelomeric heterochromatin assembly)|go:"GO:1905555"(positive regulation of blood vessel branching)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR026590|interpro:IPR029035|rcsb pdb:3K35|rcsb pdb:3PKI|rcsb pdb:3PKJ|rcsb pdb:3ZG6|rcsb pdb:5MF6|rcsb pdb:5MFP|rcsb pdb:5MFZ|rcsb pdb:5MGN|rcsb pdb:5X16|rcsb pdb:5Y2F|rcsb pdb:6HOY|rcsb pdb:6QCD|rcsb pdb:6QCE|rcsb pdb:6QCH|rcsb pdb:6QCJ|rcsb pdb:6XUY|rcsb pdb:6XV1|rcsb pdb:6XV6|rcsb pdb:6XVG|rcsb pdb:6ZU4|rcsb pdb:7CL0|rcsb pdb:7CL1|reactome:R-HSA-1912408|reactome:R-HSA-5693607|refseq:NP_001180214.1|refseq:NP_057623.2|refseq:NP_001307987.1|refseq:NP_001307988.1|refseq:NP_001307989.1|refseq:NP_001307990.1|refseq:NP_001307991.1|refseq:NP_001307992.1|refseq:NP_001307993.1|dip:DIP-47346N	ensembl:ENSG00000173039(gene)|ensembl:ENST00000406246(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|refseq:NP_001138610.1|refseq:NP_068810.3|refseq:NP_001230913.1|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0070301"(cellular response to hydrogen peroxide)|dip:DIP-24238N|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001889"(liver development)|go:"GO:0001942"(hair follicle development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006117"(acetaldehyde metabolic process)|go:"GO:0006325"(chromatin organization)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006954"(inflammatory response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007568"(aging)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010033"(response to organic substance)|go:"GO:0010224"(response to UV-B)|go:"GO:0014040"(positive regulation of Schwann cell differentiation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032495"(response to muramyl dipeptide)|go:"GO:0032570"(response to progesterone)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032868"(response to insulin)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0033234"(negative regulation of protein sumoylation)|go:"GO:0033590"(response to cobalamin)|go:"GO:0034097"(response to cytokine)|go:"GO:0035525"(NF-kappaB p50/p65 complex)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0038061"(NIK/NF-kappaB signaling)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042277"(peptide binding)|go:"GO:0042301"(phosphate ion binding)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042805"(actinin binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043200"(response to amino acid)|go:"GO:0043278"(response to morphine)|go:"GO:0043620"(regulation of DNA-templated transcription in response to stress)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051591"(response to cAMP)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0051607"(defense response to virus)|go:"GO:0070431"(nucleotide-binding oligomerization domain containing 2 signaling pathway)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071224"(cellular response to peptidoglycan)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071354"(cellular response to interleukin-6)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071532"(ankyrin repeat binding)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:0140296"(general transcription initiation factor binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1901222"(regulation of NIK/NF-kappaB signaling)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904385"(cellular response to angiotensin)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:2000630"(positive regulation of miRNA metabolic process)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000451(NF-kappa-B/Rel/dorsal)|interpro:IPR002909(Cell surface receptor IPT/TIG)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR011539(Rel homology)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR030492|interpro:IPR030495|interpro:IPR032397|interpro:IPR033926|interpro:IPR037059|mint:Q04206|rcsb pdb:1NFI|rcsb pdb:2LSP|rcsb pdb:2O61|rcsb pdb:3GUT|rcsb pdb:3QXY|rcsb pdb:3RC0|rcsb pdb:4KV1|rcsb pdb:4KV4|rcsb pdb:5U4K|rcsb pdb:5URN|rcsb pdb:6NV2|rcsb pdb:6QHL|rcsb pdb:6QHM|rcsb pdb:6YOW|rcsb pdb:6YOX|rcsb pdb:6YOY|rcsb pdb:6YP2|rcsb pdb:6YP3|rcsb pdb:6YP8|rcsb pdb:6YPL|rcsb pdb:6YPY|rcsb pdb:6YQ2|rcsb pdb:7BI3|rcsb pdb:7BIQ|rcsb pdb:7BIY|rcsb pdb:7BJF|rcsb pdb:7BJL|rcsb pdb:7BJW|rcsb pdb:7BKH|rcsb pdb:7NJ9|rcsb pdb:7NJB|rcsb pdb:7NK3|rcsb pdb:7NK5|rcsb pdb:7NLA|rcsb pdb:7NLE|rcsb pdb:7NM1|rcsb pdb:7NM3|rcsb pdb:7NM9|rcsb pdb:7NQP|rcsb pdb:7NR7|rcsb pdb:7NSV|rcsb pdb:7NV4|rcsb pdb:7NVI|rcsb pdb:7NWS|rcsb pdb:7NXS|rcsb pdb:7NXT|rcsb pdb:7NXW|rcsb pdb:7NXY|rcsb pdb:7NY4|rcsb pdb:7NYE|rcsb pdb:7NYF|rcsb pdb:7NYG|rcsb pdb:7NZ6|rcsb pdb:7NZG|rcsb pdb:7NZK|rcsb pdb:7NZV|rcsb pdb:7O34|rcsb pdb:7O3A|rcsb pdb:7O3F|rcsb pdb:7O3P|rcsb pdb:7O3Q|rcsb pdb:7O3R|rcsb pdb:7O3S|rcsb pdb:7O57|rcsb pdb:7O59|rcsb pdb:7O5A|rcsb pdb:7O5C|rcsb pdb:7O5D|rcsb pdb:7O5F|rcsb pdb:7O5G|rcsb pdb:7O5O|rcsb pdb:7O5P|rcsb pdb:7O5S|rcsb pdb:7O5U|rcsb pdb:7O5X|rcsb pdb:7O6F|rcsb pdb:7O6G|rcsb pdb:7O6I|rcsb pdb:7O6J|rcsb pdb:7O6K|rcsb pdb:7O6M|rcsb pdb:7O6O|reactome:R-HSA-1169091|reactome:R-HSA-1810476|reactome:R-HSA-193692|reactome:R-HSA-202424|reactome:R-HSA-209560|reactome:R-HSA-2559582|reactome:R-HSA-2871837|reactome:R-HSA-3134963|reactome:R-HSA-3214841|reactome:R-HSA-381340|reactome:R-HSA-445989|reactome:R-HSA-448706|reactome:R-HSA-4755510|reactome:R-HSA-5603029|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5621575|reactome:R-HSA-5660668|reactome:R-HSA-844456|reactome:R-HSA-8853884|reactome:R-HSA-9020702|reactome:R-HSA-933542|reactome:R-HSA-9660826	psi-mi:"MI:0469"(intact)	-	-	figure legend:Figs. 1B, 1, Supp. Fig 1A|agonist:"TNF-alpha (20 ng/ml)"|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2009/01/27	2014/10/16	rogid:r/bhvugj+nCc5ya3cg9qs2VuAJU9606	rogid:w/ClZ7PzdLH1LLxTGrk22KUz8V49606	intact-crc:6C1DC0D9F3E44A58|rigid:fdQ/Li0/RXgArVYol4f8+7kd8pg	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8N6T7	uniprotkb:Q04206	intact:EBI-712415|ensembl:ENSP00000337332|uniprotkb:O75291|uniprotkb:Q6IAF5|uniprotkb:Q6PK99|uniprotkb:Q8NCD2|uniprotkb:Q9BSI5|uniprotkb:Q9BWP3|uniprotkb:Q9NRC7|uniprotkb:Q9UQD1|uniprotkb:B2RCD0	intact:EBI-73886|ensembl:ENSP00000384273|uniprotkb:Q6GTV1|uniprotkb:Q6SLK1	psi-mi:sir6_human(display_long)|uniprotkb:SIR2-like protein 6(gene name synonym)|uniprotkb:SIRT6(gene name)|psi-mi:SIRT6(display_short)|uniprotkb:SIR2L6(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 6(gene name synonym)	psi-mi:tf65_human(display_long)|uniprotkb:Nuclear factor NF-kappa-B p65 subunit(gene name synonym)|uniprotkb:RELA(gene name)|psi-mi:RELA(display_short)|uniprotkb:NFKB3(gene name synonym)|uniprotkb:Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Kawahara et al. (2009)	imex:IM-12156|pubmed:19135889	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2213831|imex:IM-12156-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000077463(gene)|ensembl:ENST00000337491(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003247"(post-embryonic cardiac muscle cell growth involved in heart morphogenesis)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0003956"("NAD(P)+-protein-arginine ADP-ribosyltransferase activity")|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010569"(regulation of double-strand break repair via homologous recombination)|go:"GO:0017136"(NAD-dependent histone deacetylase activity)|go:"GO:0019213"(deacetylase activity)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0031940"(obsolete positive regulation of chromatin silencing at telomere)|go:"GO:0032206"(positive regulation of telomere maintenance)|go:"GO:0034979"(NAD-dependent protein deacetylase activity)|go:"GO:0046969"("NAD-dependent histone deacetylase activity (H3-K9 specific)")|go:"GO:0070403"(NAD+ binding)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0099115"(chromosome, subtelomeric region)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1901485"(positive regulation of transcription factor catabolic process)|go:"GO:1902732"(positive regulation of chondrocyte proliferation)|go:"GO:1905549"(obsolete positive regulation of subtelomeric heterochromatin assembly)|go:"GO:1905555"(positive regulation of blood vessel branching)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR026590|interpro:IPR029035|rcsb pdb:3K35|rcsb pdb:3PKI|rcsb pdb:3PKJ|rcsb pdb:3ZG6|rcsb pdb:5MF6|rcsb pdb:5MFP|rcsb pdb:5MFZ|rcsb pdb:5MGN|rcsb pdb:5X16|rcsb pdb:5Y2F|rcsb pdb:6HOY|rcsb pdb:6QCD|rcsb pdb:6QCE|rcsb pdb:6QCH|rcsb pdb:6QCJ|rcsb pdb:6XUY|rcsb pdb:6XV1|rcsb pdb:6XV6|rcsb pdb:6XVG|rcsb pdb:6ZU4|rcsb pdb:7CL0|rcsb pdb:7CL1|reactome:R-HSA-1912408|reactome:R-HSA-5693607|refseq:NP_001180214.1|refseq:NP_057623.2|refseq:NP_001307987.1|refseq:NP_001307988.1|refseq:NP_001307989.1|refseq:NP_001307990.1|refseq:NP_001307991.1|refseq:NP_001307992.1|refseq:NP_001307993.1|dip:DIP-47346N	ensembl:ENSG00000173039(gene)|ensembl:ENST00000406246(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|refseq:NP_001138610.1|refseq:NP_068810.3|refseq:NP_001230913.1|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0070301"(cellular response to hydrogen peroxide)|dip:DIP-24238N|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001889"(liver development)|go:"GO:0001942"(hair follicle development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006117"(acetaldehyde metabolic process)|go:"GO:0006325"(chromatin organization)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006954"(inflammatory response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007568"(aging)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010033"(response to organic substance)|go:"GO:0010224"(response to UV-B)|go:"GO:0014040"(positive regulation of Schwann cell differentiation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032495"(response to muramyl dipeptide)|go:"GO:0032570"(response to progesterone)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032868"(response to insulin)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0033234"(negative regulation of protein sumoylation)|go:"GO:0033590"(response to cobalamin)|go:"GO:0034097"(response to cytokine)|go:"GO:0035525"(NF-kappaB p50/p65 complex)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0038061"(NIK/NF-kappaB signaling)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042277"(peptide binding)|go:"GO:0042301"(phosphate ion binding)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042805"(actinin binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043200"(response to amino acid)|go:"GO:0043278"(response to morphine)|go:"GO:0043620"(regulation of DNA-templated transcription in response to stress)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051591"(response to cAMP)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0051607"(defense response to virus)|go:"GO:0070431"(nucleotide-binding oligomerization domain containing 2 signaling pathway)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071224"(cellular response to peptidoglycan)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071354"(cellular response to interleukin-6)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071532"(ankyrin repeat binding)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:0140296"(general transcription initiation factor binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1901222"(regulation of NIK/NF-kappaB signaling)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904385"(cellular response to angiotensin)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:2000630"(positive regulation of miRNA metabolic process)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000451(NF-kappa-B/Rel/dorsal)|interpro:IPR002909(Cell surface receptor IPT/TIG)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR011539(Rel homology)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR030492|interpro:IPR030495|interpro:IPR032397|interpro:IPR033926|interpro:IPR037059|mint:Q04206|rcsb pdb:1NFI|rcsb pdb:2LSP|rcsb pdb:2O61|rcsb pdb:3GUT|rcsb pdb:3QXY|rcsb pdb:3RC0|rcsb pdb:4KV1|rcsb pdb:4KV4|rcsb pdb:5U4K|rcsb pdb:5URN|rcsb pdb:6NV2|rcsb pdb:6QHL|rcsb pdb:6QHM|rcsb pdb:6YOW|rcsb pdb:6YOX|rcsb pdb:6YOY|rcsb pdb:6YP2|rcsb pdb:6YP3|rcsb pdb:6YP8|rcsb pdb:6YPL|rcsb pdb:6YPY|rcsb pdb:6YQ2|rcsb pdb:7BI3|rcsb pdb:7BIQ|rcsb pdb:7BIY|rcsb pdb:7BJF|rcsb pdb:7BJL|rcsb pdb:7BJW|rcsb pdb:7BKH|rcsb pdb:7NJ9|rcsb pdb:7NJB|rcsb pdb:7NK3|rcsb pdb:7NK5|rcsb pdb:7NLA|rcsb pdb:7NLE|rcsb pdb:7NM1|rcsb pdb:7NM3|rcsb pdb:7NM9|rcsb pdb:7NQP|rcsb pdb:7NR7|rcsb pdb:7NSV|rcsb pdb:7NV4|rcsb pdb:7NVI|rcsb pdb:7NWS|rcsb pdb:7NXS|rcsb pdb:7NXT|rcsb pdb:7NXW|rcsb pdb:7NXY|rcsb pdb:7NY4|rcsb pdb:7NYE|rcsb pdb:7NYF|rcsb pdb:7NYG|rcsb pdb:7NZ6|rcsb pdb:7NZG|rcsb pdb:7NZK|rcsb pdb:7NZV|rcsb pdb:7O34|rcsb pdb:7O3A|rcsb pdb:7O3F|rcsb pdb:7O3P|rcsb pdb:7O3Q|rcsb pdb:7O3R|rcsb pdb:7O3S|rcsb pdb:7O57|rcsb pdb:7O59|rcsb pdb:7O5A|rcsb pdb:7O5C|rcsb pdb:7O5D|rcsb pdb:7O5F|rcsb pdb:7O5G|rcsb pdb:7O5O|rcsb pdb:7O5P|rcsb pdb:7O5S|rcsb pdb:7O5U|rcsb pdb:7O5X|rcsb pdb:7O6F|rcsb pdb:7O6G|rcsb pdb:7O6I|rcsb pdb:7O6J|rcsb pdb:7O6K|rcsb pdb:7O6M|rcsb pdb:7O6O|reactome:R-HSA-1169091|reactome:R-HSA-1810476|reactome:R-HSA-193692|reactome:R-HSA-202424|reactome:R-HSA-209560|reactome:R-HSA-2559582|reactome:R-HSA-2871837|reactome:R-HSA-3134963|reactome:R-HSA-3214841|reactome:R-HSA-381340|reactome:R-HSA-445989|reactome:R-HSA-448706|reactome:R-HSA-4755510|reactome:R-HSA-5603029|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5621575|reactome:R-HSA-5660668|reactome:R-HSA-844456|reactome:R-HSA-8853884|reactome:R-HSA-9020702|reactome:R-HSA-933542|reactome:R-HSA-9660826	psi-mi:"MI:0469"(intact)	-	-	figure legend:Supp. Fig 1B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2009/01/27	2014/10/16	rogid:r/bhvugj+nCc5ya3cg9qs2VuAJU9606	rogid:w/ClZ7PzdLH1LLxTGrk22KUz8V49606	intact-crc:41A0573BE746DDBC|rigid:fdQ/Li0/RXgArVYol4f8+7kd8pg	false	-	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8N6T7	uniprotkb:Q04206	intact:EBI-712415|ensembl:ENSP00000337332|uniprotkb:O75291|uniprotkb:Q6IAF5|uniprotkb:Q6PK99|uniprotkb:Q8NCD2|uniprotkb:Q9BSI5|uniprotkb:Q9BWP3|uniprotkb:Q9NRC7|uniprotkb:Q9UQD1|uniprotkb:B2RCD0	intact:EBI-73886|ensembl:ENSP00000384273|uniprotkb:Q6GTV1|uniprotkb:Q6SLK1	psi-mi:sir6_human(display_long)|uniprotkb:SIR2-like protein 6(gene name synonym)|uniprotkb:SIRT6(gene name)|psi-mi:SIRT6(display_short)|uniprotkb:SIR2L6(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 6(gene name synonym)	psi-mi:tf65_human(display_long)|uniprotkb:Nuclear factor NF-kappa-B p65 subunit(gene name synonym)|uniprotkb:RELA(gene name)|psi-mi:RELA(display_short)|uniprotkb:NFKB3(gene name synonym)|uniprotkb:Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Kawahara et al. (2009)	imex:IM-12156|pubmed:19135889	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2213822|imex:IM-12156-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000077463(gene)|ensembl:ENST00000337491(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003247"(post-embryonic cardiac muscle cell growth involved in heart morphogenesis)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0003956"("NAD(P)+-protein-arginine ADP-ribosyltransferase activity")|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010569"(regulation of double-strand break repair via homologous recombination)|go:"GO:0017136"(NAD-dependent histone deacetylase activity)|go:"GO:0019213"(deacetylase activity)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0031940"(obsolete positive regulation of chromatin silencing at telomere)|go:"GO:0032206"(positive regulation of telomere maintenance)|go:"GO:0034979"(NAD-dependent protein deacetylase activity)|go:"GO:0046969"("NAD-dependent histone deacetylase activity (H3-K9 specific)")|go:"GO:0070403"(NAD+ binding)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0099115"(chromosome, subtelomeric region)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1901485"(positive regulation of transcription factor catabolic process)|go:"GO:1902732"(positive regulation of chondrocyte proliferation)|go:"GO:1905549"(obsolete positive regulation of subtelomeric heterochromatin assembly)|go:"GO:1905555"(positive regulation of blood vessel branching)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR026590|interpro:IPR029035|rcsb pdb:3K35|rcsb pdb:3PKI|rcsb pdb:3PKJ|rcsb pdb:3ZG6|rcsb pdb:5MF6|rcsb pdb:5MFP|rcsb pdb:5MFZ|rcsb pdb:5MGN|rcsb pdb:5X16|rcsb pdb:5Y2F|rcsb pdb:6HOY|rcsb pdb:6QCD|rcsb pdb:6QCE|rcsb pdb:6QCH|rcsb pdb:6QCJ|rcsb pdb:6XUY|rcsb pdb:6XV1|rcsb pdb:6XV6|rcsb pdb:6XVG|rcsb pdb:6ZU4|rcsb pdb:7CL0|rcsb pdb:7CL1|reactome:R-HSA-1912408|reactome:R-HSA-5693607|refseq:NP_001180214.1|refseq:NP_057623.2|refseq:NP_001307987.1|refseq:NP_001307988.1|refseq:NP_001307989.1|refseq:NP_001307990.1|refseq:NP_001307991.1|refseq:NP_001307992.1|refseq:NP_001307993.1|dip:DIP-47346N	ensembl:ENSG00000173039(gene)|ensembl:ENST00000406246(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|refseq:NP_001138610.1|refseq:NP_068810.3|refseq:NP_001230913.1|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0070301"(cellular response to hydrogen peroxide)|dip:DIP-24238N|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001889"(liver development)|go:"GO:0001942"(hair follicle development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006117"(acetaldehyde metabolic process)|go:"GO:0006325"(chromatin organization)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006954"(inflammatory response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007568"(aging)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010033"(response to organic substance)|go:"GO:0010224"(response to UV-B)|go:"GO:0014040"(positive regulation of Schwann cell differentiation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032495"(response to muramyl dipeptide)|go:"GO:0032570"(response to progesterone)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032868"(response to insulin)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0033234"(negative regulation of protein sumoylation)|go:"GO:0033590"(response to cobalamin)|go:"GO:0034097"(response to cytokine)|go:"GO:0035525"(NF-kappaB p50/p65 complex)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0038061"(NIK/NF-kappaB signaling)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042277"(peptide binding)|go:"GO:0042301"(phosphate ion binding)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042805"(actinin binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043200"(response to amino acid)|go:"GO:0043278"(response to morphine)|go:"GO:0043620"(regulation of DNA-templated transcription in response to stress)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051591"(response to cAMP)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0051607"(defense response to virus)|go:"GO:0070431"(nucleotide-binding oligomerization domain containing 2 signaling pathway)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071224"(cellular response to peptidoglycan)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071354"(cellular response to interleukin-6)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071532"(ankyrin repeat binding)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:0140296"(general transcription initiation factor binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1901222"(regulation of NIK/NF-kappaB signaling)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904385"(cellular response to angiotensin)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:2000630"(positive regulation of miRNA metabolic process)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000451(NF-kappa-B/Rel/dorsal)|interpro:IPR002909(Cell surface receptor IPT/TIG)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR011539(Rel homology)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR030492|interpro:IPR030495|interpro:IPR032397|interpro:IPR033926|interpro:IPR037059|mint:Q04206|rcsb pdb:1NFI|rcsb pdb:2LSP|rcsb pdb:2O61|rcsb pdb:3GUT|rcsb pdb:3QXY|rcsb pdb:3RC0|rcsb pdb:4KV1|rcsb pdb:4KV4|rcsb pdb:5U4K|rcsb pdb:5URN|rcsb pdb:6NV2|rcsb pdb:6QHL|rcsb pdb:6QHM|rcsb pdb:6YOW|rcsb pdb:6YOX|rcsb pdb:6YOY|rcsb pdb:6YP2|rcsb pdb:6YP3|rcsb pdb:6YP8|rcsb pdb:6YPL|rcsb pdb:6YPY|rcsb pdb:6YQ2|rcsb pdb:7BI3|rcsb pdb:7BIQ|rcsb pdb:7BIY|rcsb pdb:7BJF|rcsb pdb:7BJL|rcsb pdb:7BJW|rcsb pdb:7BKH|rcsb pdb:7NJ9|rcsb pdb:7NJB|rcsb pdb:7NK3|rcsb pdb:7NK5|rcsb pdb:7NLA|rcsb pdb:7NLE|rcsb pdb:7NM1|rcsb pdb:7NM3|rcsb pdb:7NM9|rcsb pdb:7NQP|rcsb pdb:7NR7|rcsb pdb:7NSV|rcsb pdb:7NV4|rcsb pdb:7NVI|rcsb pdb:7NWS|rcsb pdb:7NXS|rcsb pdb:7NXT|rcsb pdb:7NXW|rcsb pdb:7NXY|rcsb pdb:7NY4|rcsb pdb:7NYE|rcsb pdb:7NYF|rcsb pdb:7NYG|rcsb pdb:7NZ6|rcsb pdb:7NZG|rcsb pdb:7NZK|rcsb pdb:7NZV|rcsb pdb:7O34|rcsb pdb:7O3A|rcsb pdb:7O3F|rcsb pdb:7O3P|rcsb pdb:7O3Q|rcsb pdb:7O3R|rcsb pdb:7O3S|rcsb pdb:7O57|rcsb pdb:7O59|rcsb pdb:7O5A|rcsb pdb:7O5C|rcsb pdb:7O5D|rcsb pdb:7O5F|rcsb pdb:7O5G|rcsb pdb:7O5O|rcsb pdb:7O5P|rcsb pdb:7O5S|rcsb pdb:7O5U|rcsb pdb:7O5X|rcsb pdb:7O6F|rcsb pdb:7O6G|rcsb pdb:7O6I|rcsb pdb:7O6J|rcsb pdb:7O6K|rcsb pdb:7O6M|rcsb pdb:7O6O|reactome:R-HSA-1169091|reactome:R-HSA-1810476|reactome:R-HSA-193692|reactome:R-HSA-202424|reactome:R-HSA-209560|reactome:R-HSA-2559582|reactome:R-HSA-2871837|reactome:R-HSA-3134963|reactome:R-HSA-3214841|reactome:R-HSA-381340|reactome:R-HSA-445989|reactome:R-HSA-448706|reactome:R-HSA-4755510|reactome:R-HSA-5603029|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5621575|reactome:R-HSA-5660668|reactome:R-HSA-844456|reactome:R-HSA-8853884|reactome:R-HSA-9020702|reactome:R-HSA-933542|reactome:R-HSA-9660826	psi-mi:"MI:0469"(intact)	-	-	figure legend:Fig. 1A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells)	-	2009/01/27	2014/10/16	rogid:r/bhvugj+nCc5ya3cg9qs2VuAJU9606	rogid:w/ClZ7PzdLH1LLxTGrk22KUz8V49606	intact-crc:578AC7414DFBE033|rigid:fdQ/Li0/RXgArVYol4f8+7kd8pg	false	flag tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q8N6T7	uniprotkb:Q04206	intact:EBI-712415|ensembl:ENSP00000337332|uniprotkb:O75291|uniprotkb:Q6IAF5|uniprotkb:Q6PK99|uniprotkb:Q8NCD2|uniprotkb:Q9BSI5|uniprotkb:Q9BWP3|uniprotkb:Q9NRC7|uniprotkb:Q9UQD1|uniprotkb:B2RCD0	intact:EBI-73886|ensembl:ENSP00000384273|uniprotkb:Q6GTV1|uniprotkb:Q6SLK1	psi-mi:sir6_human(display_long)|uniprotkb:SIR2-like protein 6(gene name synonym)|uniprotkb:SIRT6(gene name)|psi-mi:SIRT6(display_short)|uniprotkb:SIR2L6(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 6(gene name synonym)	psi-mi:tf65_human(display_long)|uniprotkb:Nuclear factor NF-kappa-B p65 subunit(gene name synonym)|uniprotkb:RELA(gene name)|psi-mi:RELA(display_short)|uniprotkb:NFKB3(gene name synonym)|uniprotkb:Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3(gene name synonym)	psi-mi:"MI:0096"(pull down)	Kawahara et al. (2009)	imex:IM-12156|pubmed:19135889	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2213843|imex:IM-12156-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSG00000077463(gene)|ensembl:ENST00000337491(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003247"(post-embryonic cardiac muscle cell growth involved in heart morphogenesis)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0003956"("NAD(P)+-protein-arginine ADP-ribosyltransferase activity")|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010569"(regulation of double-strand break repair via homologous recombination)|go:"GO:0017136"(NAD-dependent histone deacetylase activity)|go:"GO:0019213"(deacetylase activity)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0031940"(obsolete positive regulation of chromatin silencing at telomere)|go:"GO:0032206"(positive regulation of telomere maintenance)|go:"GO:0034979"(NAD-dependent protein deacetylase activity)|go:"GO:0046969"("NAD-dependent histone deacetylase activity (H3-K9 specific)")|go:"GO:0070403"(NAD+ binding)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0099115"(chromosome, subtelomeric region)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1901485"(positive regulation of transcription factor catabolic process)|go:"GO:1902732"(positive regulation of chondrocyte proliferation)|go:"GO:1905549"(obsolete positive regulation of subtelomeric heterochromatin assembly)|go:"GO:1905555"(positive regulation of blood vessel branching)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR026590|interpro:IPR029035|rcsb pdb:3K35|rcsb pdb:3PKI|rcsb pdb:3PKJ|rcsb pdb:3ZG6|rcsb pdb:5MF6|rcsb pdb:5MFP|rcsb pdb:5MFZ|rcsb pdb:5MGN|rcsb pdb:5X16|rcsb pdb:5Y2F|rcsb pdb:6HOY|rcsb pdb:6QCD|rcsb pdb:6QCE|rcsb pdb:6QCH|rcsb pdb:6QCJ|rcsb pdb:6XUY|rcsb pdb:6XV1|rcsb pdb:6XV6|rcsb pdb:6XVG|rcsb pdb:6ZU4|rcsb pdb:7CL0|rcsb pdb:7CL1|reactome:R-HSA-1912408|reactome:R-HSA-5693607|refseq:NP_001180214.1|refseq:NP_057623.2|refseq:NP_001307987.1|refseq:NP_001307988.1|refseq:NP_001307989.1|refseq:NP_001307990.1|refseq:NP_001307991.1|refseq:NP_001307992.1|refseq:NP_001307993.1|dip:DIP-47346N	ensembl:ENSG00000173039(gene)|ensembl:ENST00000406246(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|refseq:NP_001138610.1|refseq:NP_068810.3|refseq:NP_001230913.1|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0070301"(cellular response to hydrogen peroxide)|dip:DIP-24238N|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001889"(liver development)|go:"GO:0001942"(hair follicle development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006117"(acetaldehyde metabolic process)|go:"GO:0006325"(chromatin organization)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006954"(inflammatory response)|go:"GO:0006968"(cellular defense response)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007568"(aging)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010033"(response to organic substance)|go:"GO:0010224"(response to UV-B)|go:"GO:0014040"(positive regulation of Schwann cell differentiation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032495"(response to muramyl dipeptide)|go:"GO:0032570"(response to progesterone)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032868"(response to insulin)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0033234"(negative regulation of protein sumoylation)|go:"GO:0033590"(response to cobalamin)|go:"GO:0034097"(response to cytokine)|go:"GO:0035525"(NF-kappaB p50/p65 complex)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0038061"(NIK/NF-kappaB signaling)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042277"(peptide binding)|go:"GO:0042301"(phosphate ion binding)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042805"(actinin binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043200"(response to amino acid)|go:"GO:0043278"(response to morphine)|go:"GO:0043620"(regulation of DNA-templated transcription in response to stress)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051591"(response to cAMP)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0051607"(defense response to virus)|go:"GO:0070431"(nucleotide-binding oligomerization domain containing 2 signaling pathway)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071224"(cellular response to peptidoglycan)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071354"(cellular response to interleukin-6)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071532"(ankyrin repeat binding)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:0140296"(general transcription initiation factor binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1901222"(regulation of NIK/NF-kappaB signaling)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904385"(cellular response to angiotensin)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:2000630"(positive regulation of miRNA metabolic process)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000451(NF-kappa-B/Rel/dorsal)|interpro:IPR002909(Cell surface receptor IPT/TIG)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR011539(Rel homology)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR030492|interpro:IPR030495|interpro:IPR032397|interpro:IPR033926|interpro:IPR037059|mint:Q04206|rcsb pdb:1NFI|rcsb pdb:2LSP|rcsb pdb:2O61|rcsb pdb:3GUT|rcsb pdb:3QXY|rcsb pdb:3RC0|rcsb pdb:4KV1|rcsb pdb:4KV4|rcsb pdb:5U4K|rcsb pdb:5URN|rcsb pdb:6NV2|rcsb pdb:6QHL|rcsb pdb:6QHM|rcsb pdb:6YOW|rcsb pdb:6YOX|rcsb pdb:6YOY|rcsb pdb:6YP2|rcsb pdb:6YP3|rcsb pdb:6YP8|rcsb pdb:6YPL|rcsb pdb:6YPY|rcsb pdb:6YQ2|rcsb pdb:7BI3|rcsb pdb:7BIQ|rcsb pdb:7BIY|rcsb pdb:7BJF|rcsb pdb:7BJL|rcsb pdb:7BJW|rcsb pdb:7BKH|rcsb pdb:7NJ9|rcsb pdb:7NJB|rcsb pdb:7NK3|rcsb pdb:7NK5|rcsb pdb:7NLA|rcsb pdb:7NLE|rcsb pdb:7NM1|rcsb pdb:7NM3|rcsb pdb:7NM9|rcsb pdb:7NQP|rcsb pdb:7NR7|rcsb pdb:7NSV|rcsb pdb:7NV4|rcsb pdb:7NVI|rcsb pdb:7NWS|rcsb pdb:7NXS|rcsb pdb:7NXT|rcsb pdb:7NXW|rcsb pdb:7NXY|rcsb pdb:7NY4|rcsb pdb:7NYE|rcsb pdb:7NYF|rcsb pdb:7NYG|rcsb pdb:7NZ6|rcsb pdb:7NZG|rcsb pdb:7NZK|rcsb pdb:7NZV|rcsb pdb:7O34|rcsb pdb:7O3A|rcsb pdb:7O3F|rcsb pdb:7O3P|rcsb pdb:7O3Q|rcsb pdb:7O3R|rcsb pdb:7O3S|rcsb pdb:7O57|rcsb pdb:7O59|rcsb pdb:7O5A|rcsb pdb:7O5C|rcsb pdb:7O5D|rcsb pdb:7O5F|rcsb pdb:7O5G|rcsb pdb:7O5O|rcsb pdb:7O5P|rcsb pdb:7O5S|rcsb pdb:7O5U|rcsb pdb:7O5X|rcsb pdb:7O6F|rcsb pdb:7O6G|rcsb pdb:7O6I|rcsb pdb:7O6J|rcsb pdb:7O6K|rcsb pdb:7O6M|rcsb pdb:7O6O|reactome:R-HSA-1169091|reactome:R-HSA-1810476|reactome:R-HSA-193692|reactome:R-HSA-202424|reactome:R-HSA-209560|reactome:R-HSA-2559582|reactome:R-HSA-2871837|reactome:R-HSA-3134963|reactome:R-HSA-3214841|reactome:R-HSA-381340|reactome:R-HSA-445989|reactome:R-HSA-448706|reactome:R-HSA-4755510|reactome:R-HSA-5603029|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5621575|reactome:R-HSA-5660668|reactome:R-HSA-844456|reactome:R-HSA-8853884|reactome:R-HSA-9020702|reactome:R-HSA-933542|reactome:R-HSA-9660826	psi-mi:"MI:0469"(intact)	-	-	figure legend:Figs. 1D, 1E|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/01/27	2014/10/16	rogid:r/bhvugj+nCc5ya3cg9qs2VuAJU9606	rogid:w/ClZ7PzdLH1LLxTGrk22KUz8V49606	intact-crc:CE1F4412040C6613|rigid:fdQ/Li0/RXgArVYol4f8+7kd8pg	false	sufficient binding region:?-?|glutathione s tranferase tag:?-?	-	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0113"(western blot)
ensembl:ENSG00000023445	uniprotkb:Q8N6T7	intact:EBI-2213855	intact:EBI-712415|ensembl:ENSP00000337332|uniprotkb:O75291|uniprotkb:Q6IAF5|uniprotkb:Q6PK99|uniprotkb:Q8NCD2|uniprotkb:Q9BSI5|uniprotkb:Q9BWP3|uniprotkb:Q9NRC7|uniprotkb:Q9UQD1|uniprotkb:B2RCD0	psi-mi:birc3_human_gene(display_short)|psi-mi:ENSG00000023445(display_long)	psi-mi:sir6_human(display_long)|uniprotkb:SIR2-like protein 6(gene name synonym)|uniprotkb:SIRT6(gene name)|psi-mi:SIRT6(display_short)|uniprotkb:SIR2L6(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 6(gene name synonym)	psi-mi:"MI:0402"(chromatin immunoprecipitation assay)	Kawahara et al. (2009)	imex:IM-12156|pubmed:19135889	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2213865|imex:IM-12156-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0250"(gene)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000077463(gene)|ensembl:ENST00000337491(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003247"(post-embryonic cardiac muscle cell growth involved in heart morphogenesis)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0003956"("NAD(P)+-protein-arginine ADP-ribosyltransferase activity")|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010569"(regulation of double-strand break repair via homologous recombination)|go:"GO:0017136"(NAD-dependent histone deacetylase activity)|go:"GO:0019213"(deacetylase activity)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0031940"(obsolete positive regulation of chromatin silencing at telomere)|go:"GO:0032206"(positive regulation of telomere maintenance)|go:"GO:0034979"(NAD-dependent protein deacetylase activity)|go:"GO:0046969"("NAD-dependent histone deacetylase activity (H3-K9 specific)")|go:"GO:0070403"(NAD+ binding)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0099115"(chromosome, subtelomeric region)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1901485"(positive regulation of transcription factor catabolic process)|go:"GO:1902732"(positive regulation of chondrocyte proliferation)|go:"GO:1905549"(obsolete positive regulation of subtelomeric heterochromatin assembly)|go:"GO:1905555"(positive regulation of blood vessel branching)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR026590|interpro:IPR029035|rcsb pdb:3K35|rcsb pdb:3PKI|rcsb pdb:3PKJ|rcsb pdb:3ZG6|rcsb pdb:5MF6|rcsb pdb:5MFP|rcsb pdb:5MFZ|rcsb pdb:5MGN|rcsb pdb:5X16|rcsb pdb:5Y2F|rcsb pdb:6HOY|rcsb pdb:6QCD|rcsb pdb:6QCE|rcsb pdb:6QCH|rcsb pdb:6QCJ|rcsb pdb:6XUY|rcsb pdb:6XV1|rcsb pdb:6XV6|rcsb pdb:6XVG|rcsb pdb:6ZU4|rcsb pdb:7CL0|rcsb pdb:7CL1|reactome:R-HSA-1912408|reactome:R-HSA-5693607|refseq:NP_001180214.1|refseq:NP_057623.2|refseq:NP_001307987.1|refseq:NP_001307988.1|refseq:NP_001307989.1|refseq:NP_001307990.1|refseq:NP_001307991.1|refseq:NP_001307992.1|refseq:NP_001307993.1|dip:DIP-47346N	-	-	-	figure legend:Fig. 2A|agonist:"TNF-alpha (20 ng/ml)"|comment:Binding was to the promoter region of the gene|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2009/01/27	2014/10/16	-	rogid:r/bhvugj+nCc5ya3cg9qs2VuAJU9606	intact-crc:95226A31EF69EAAD	false	-	flag tag:?-?	-	-	psi-mi:"MI:0088"(primer specific pcr)	psi-mi:"MI:0088"(primer specific pcr)
ensembl:ENSG00000112096	uniprotkb:Q8N6T7	intact:EBI-6620385	intact:EBI-712415|ensembl:ENSP00000337332|uniprotkb:O75291|uniprotkb:Q6IAF5|uniprotkb:Q6PK99|uniprotkb:Q8NCD2|uniprotkb:Q9BSI5|uniprotkb:Q9BWP3|uniprotkb:Q9NRC7|uniprotkb:Q9UQD1|uniprotkb:B2RCD0	psi-mi:sodm_human_gene(display_short)|psi-mi:ENSG00000112096(display_long)	psi-mi:sir6_human(display_long)|uniprotkb:SIR2-like protein 6(gene name synonym)|uniprotkb:SIRT6(gene name)|psi-mi:SIRT6(display_short)|uniprotkb:SIR2L6(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 6(gene name synonym)	psi-mi:"MI:0402"(chromatin immunoprecipitation assay)	Kawahara et al. (2009)	imex:IM-12156|pubmed:19135889	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2213873|imex:IM-12156-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0250"(gene)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000077463(gene)|ensembl:ENST00000337491(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003247"(post-embryonic cardiac muscle cell growth involved in heart morphogenesis)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0003956"("NAD(P)+-protein-arginine ADP-ribosyltransferase activity")|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010569"(regulation of double-strand break repair via homologous recombination)|go:"GO:0017136"(NAD-dependent histone deacetylase activity)|go:"GO:0019213"(deacetylase activity)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0031940"(obsolete positive regulation of chromatin silencing at telomere)|go:"GO:0032206"(positive regulation of telomere maintenance)|go:"GO:0034979"(NAD-dependent protein deacetylase activity)|go:"GO:0046969"("NAD-dependent histone deacetylase activity (H3-K9 specific)")|go:"GO:0070403"(NAD+ binding)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0099115"(chromosome, subtelomeric region)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1901485"(positive regulation of transcription factor catabolic process)|go:"GO:1902732"(positive regulation of chondrocyte proliferation)|go:"GO:1905549"(obsolete positive regulation of subtelomeric heterochromatin assembly)|go:"GO:1905555"(positive regulation of blood vessel branching)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR026590|interpro:IPR029035|rcsb pdb:3K35|rcsb pdb:3PKI|rcsb pdb:3PKJ|rcsb pdb:3ZG6|rcsb pdb:5MF6|rcsb pdb:5MFP|rcsb pdb:5MFZ|rcsb pdb:5MGN|rcsb pdb:5X16|rcsb pdb:5Y2F|rcsb pdb:6HOY|rcsb pdb:6QCD|rcsb pdb:6QCE|rcsb pdb:6QCH|rcsb pdb:6QCJ|rcsb pdb:6XUY|rcsb pdb:6XV1|rcsb pdb:6XV6|rcsb pdb:6XVG|rcsb pdb:6ZU4|rcsb pdb:7CL0|rcsb pdb:7CL1|reactome:R-HSA-1912408|reactome:R-HSA-5693607|refseq:NP_001180214.1|refseq:NP_057623.2|refseq:NP_001307987.1|refseq:NP_001307988.1|refseq:NP_001307989.1|refseq:NP_001307990.1|refseq:NP_001307991.1|refseq:NP_001307992.1|refseq:NP_001307993.1|dip:DIP-47346N	-	-	-	figure legend:Fig. 2A|agonist:"TNF-alpha (20 ng/ml)"|comment:Binding was to the promoter region of the gene|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2009/01/27	2014/10/16	-	rogid:r/bhvugj+nCc5ya3cg9qs2VuAJU9606	intact-crc:9D257D74C5F168C3	false	-	flag tag:?-?	-	-	psi-mi:"MI:0088"(primer specific pcr)	psi-mi:"MI:0088"(primer specific pcr)
uniprotkb:Q8N6T7	ensembl:ENSG00000023445	intact:EBI-712415|ensembl:ENSP00000337332|uniprotkb:O75291|uniprotkb:Q6IAF5|uniprotkb:Q6PK99|uniprotkb:Q8NCD2|uniprotkb:Q9BSI5|uniprotkb:Q9BWP3|uniprotkb:Q9NRC7|uniprotkb:Q9UQD1|uniprotkb:B2RCD0	intact:EBI-2213855	psi-mi:sir6_human(display_long)|uniprotkb:SIR2-like protein 6(gene name synonym)|uniprotkb:SIRT6(gene name)|psi-mi:SIRT6(display_short)|uniprotkb:SIR2L6(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 6(gene name synonym)	psi-mi:birc3_human_gene(display_short)|psi-mi:ENSG00000023445(display_long)	psi-mi:"MI:0402"(chromatin immunoprecipitation assay)	Kawahara et al. (2009)	imex:IM-12156|pubmed:19135889	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2213883|imex:IM-12156-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0250"(gene)	ensembl:ENSG00000077463(gene)|ensembl:ENST00000337491(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003247"(post-embryonic cardiac muscle cell growth involved in heart morphogenesis)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0003956"("NAD(P)+-protein-arginine ADP-ribosyltransferase activity")|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010569"(regulation of double-strand break repair via homologous recombination)|go:"GO:0017136"(NAD-dependent histone deacetylase activity)|go:"GO:0019213"(deacetylase activity)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0031940"(obsolete positive regulation of chromatin silencing at telomere)|go:"GO:0032206"(positive regulation of telomere maintenance)|go:"GO:0034979"(NAD-dependent protein deacetylase activity)|go:"GO:0046969"("NAD-dependent histone deacetylase activity (H3-K9 specific)")|go:"GO:0070403"(NAD+ binding)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0099115"(chromosome, subtelomeric region)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1901485"(positive regulation of transcription factor catabolic process)|go:"GO:1902732"(positive regulation of chondrocyte proliferation)|go:"GO:1905549"(obsolete positive regulation of subtelomeric heterochromatin assembly)|go:"GO:1905555"(positive regulation of blood vessel branching)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR026590|interpro:IPR029035|rcsb pdb:3K35|rcsb pdb:3PKI|rcsb pdb:3PKJ|rcsb pdb:3ZG6|rcsb pdb:5MF6|rcsb pdb:5MFP|rcsb pdb:5MFZ|rcsb pdb:5MGN|rcsb pdb:5X16|rcsb pdb:5Y2F|rcsb pdb:6HOY|rcsb pdb:6QCD|rcsb pdb:6QCE|rcsb pdb:6QCH|rcsb pdb:6QCJ|rcsb pdb:6XUY|rcsb pdb:6XV1|rcsb pdb:6XV6|rcsb pdb:6XVG|rcsb pdb:6ZU4|rcsb pdb:7CL0|rcsb pdb:7CL1|reactome:R-HSA-1912408|reactome:R-HSA-5693607|refseq:NP_001180214.1|refseq:NP_057623.2|refseq:NP_001307987.1|refseq:NP_001307988.1|refseq:NP_001307989.1|refseq:NP_001307990.1|refseq:NP_001307991.1|refseq:NP_001307992.1|refseq:NP_001307993.1|dip:DIP-47346N	-	-	-	-	figure legend:Figs. 2B, 2D, Supp. Fig. 2|agonist:"TNF-alpha (20 ng/ml)"|comment:Binding was to the promoter region of the gene|comment:RELA is required for recruitment of SIRT6 to the promoters of NF-kappaB target genes.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2009/01/27	2014/10/16	rogid:r/bhvugj+nCc5ya3cg9qs2VuAJU9606	-	intact-crc:9CE0F27A1C0155E6	false	-	-	-	-	psi-mi:"MI:0088"(primer specific pcr)	psi-mi:"MI:0088"(primer specific pcr)
ensembl:ENSG00000112096	uniprotkb:Q8N6T7	intact:EBI-6620385	intact:EBI-712415|ensembl:ENSP00000337332|uniprotkb:O75291|uniprotkb:Q6IAF5|uniprotkb:Q6PK99|uniprotkb:Q8NCD2|uniprotkb:Q9BSI5|uniprotkb:Q9BWP3|uniprotkb:Q9NRC7|uniprotkb:Q9UQD1|uniprotkb:B2RCD0	psi-mi:sodm_human_gene(display_short)|psi-mi:ENSG00000112096(display_long)	psi-mi:sir6_human(display_long)|uniprotkb:SIR2-like protein 6(gene name synonym)|uniprotkb:SIRT6(gene name)|psi-mi:SIRT6(display_short)|uniprotkb:SIR2L6(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 6(gene name synonym)	psi-mi:"MI:0402"(chromatin immunoprecipitation assay)	Kawahara et al. (2009)	imex:IM-12156|pubmed:19135889	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2213891|imex:IM-12156-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0250"(gene)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSG00000077463(gene)|ensembl:ENST00000337491(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003247"(post-embryonic cardiac muscle cell growth involved in heart morphogenesis)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0003956"("NAD(P)+-protein-arginine ADP-ribosyltransferase activity")|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010569"(regulation of double-strand break repair via homologous recombination)|go:"GO:0017136"(NAD-dependent histone deacetylase activity)|go:"GO:0019213"(deacetylase activity)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0031940"(obsolete positive regulation of chromatin silencing at telomere)|go:"GO:0032206"(positive regulation of telomere maintenance)|go:"GO:0034979"(NAD-dependent protein deacetylase activity)|go:"GO:0046969"("NAD-dependent histone deacetylase activity (H3-K9 specific)")|go:"GO:0070403"(NAD+ binding)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0099115"(chromosome, subtelomeric region)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1901485"(positive regulation of transcription factor catabolic process)|go:"GO:1902732"(positive regulation of chondrocyte proliferation)|go:"GO:1905549"(obsolete positive regulation of subtelomeric heterochromatin assembly)|go:"GO:1905555"(positive regulation of blood vessel branching)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR026590|interpro:IPR029035|rcsb pdb:3K35|rcsb pdb:3PKI|rcsb pdb:3PKJ|rcsb pdb:3ZG6|rcsb pdb:5MF6|rcsb pdb:5MFP|rcsb pdb:5MFZ|rcsb pdb:5MGN|rcsb pdb:5X16|rcsb pdb:5Y2F|rcsb pdb:6HOY|rcsb pdb:6QCD|rcsb pdb:6QCE|rcsb pdb:6QCH|rcsb pdb:6QCJ|rcsb pdb:6XUY|rcsb pdb:6XV1|rcsb pdb:6XV6|rcsb pdb:6XVG|rcsb pdb:6ZU4|rcsb pdb:7CL0|rcsb pdb:7CL1|reactome:R-HSA-1912408|reactome:R-HSA-5693607|refseq:NP_001180214.1|refseq:NP_057623.2|refseq:NP_001307987.1|refseq:NP_001307988.1|refseq:NP_001307989.1|refseq:NP_001307990.1|refseq:NP_001307991.1|refseq:NP_001307992.1|refseq:NP_001307993.1|dip:DIP-47346N	-	-	-	figure legend:Figs. 2B, 2D, Supp. Fig. 2|agonist:"TNF-alpha (20 ng/ml)"|comment:Binding was to the promoter region of the gene|comment:RELA is required for recruitment of SIRT6 to the promoters of NF-kappaB target genes.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2009/01/27	2014/10/16	-	rogid:r/bhvugj+nCc5ya3cg9qs2VuAJU9606	intact-crc:1A0205D8208C99ED	false	-	-	-	-	psi-mi:"MI:0088"(primer specific pcr)	psi-mi:"MI:0088"(primer specific pcr)
ensembl:ENSMUSG00000032000	uniprotkb:P59941	intact:EBI-2213900	intact:EBI-2213911|ensembl:ENSMUSP00000048971	psi-mi:birc3_mouse_gene(display_short)|psi-mi:ENSMUSG00000032000(display_long)	psi-mi:sir6_mouse(display_long)|uniprotkb:Sirt6(gene name)|psi-mi:Sirt6(display_short)|uniprotkb:Sir2l6(gene name synonym)|uniprotkb:SIR2-like protein 6(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 6(gene name synonym)	psi-mi:"MI:0402"(chromatin immunoprecipitation assay)	Kawahara et al. (2009)	imex:IM-12156|pubmed:19135889	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2213929|imex:IM-12156-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0250"(gene)	psi-mi:"MI:0326"(protein)	-	refseq:NP_853617.1|ensembl:ENSMUSG00000034748(gene)|ensembl:ENSMUST00000042923(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003247"(post-embryonic cardiac muscle cell growth involved in heart morphogenesis)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003956"("NAD(P)+-protein-arginine ADP-ribosyltransferase activity")|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006284"(base-excision repair)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010569"(regulation of double-strand break repair via homologous recombination)|go:"GO:0017136"(NAD-dependent histone deacetylase activity)|go:"GO:0019213"(deacetylase activity)|go:"GO:0031648"(protein destabilization)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0031940"(obsolete positive regulation of chromatin silencing at telomere)|go:"GO:0032206"(positive regulation of telomere maintenance)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0046969"("NAD-dependent histone deacetylase activity (H3-K9 specific)")|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0070403"(NAD+ binding)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0099115"(chromosome, subtelomeric region)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1901485"(positive regulation of transcription factor catabolic process)|go:"GO:1902732"(positive regulation of chondrocyte proliferation)|go:"GO:1905549"(obsolete positive regulation of subtelomeric heterochromatin assembly)|go:"GO:1905555"(positive regulation of blood vessel branching)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR026590|interpro:IPR029035|reactome:R-MMU-5693607	-	-	-	figure legend:Supp. Fig. 3|comment:Interaction was not observed in Rela -/- cells|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2009/01/27	2014/10/16	-	rogid:aa94tMFcxF2sGVOsaTEmfv5O+xg10090	intact-crc:F4346A1212F30032	false	-	-	-	-	psi-mi:"MI:0088"(primer specific pcr)	psi-mi:"MI:0088"(primer specific pcr)
ensembl:ENSMUSG00000026069	uniprotkb:P59941	intact:EBI-2213902	intact:EBI-2213911|ensembl:ENSMUSP00000048971	psi-mi:il1rl1_mouse_gene(display_short)|psi-mi:ENSMUSG00000026069(display_long)	psi-mi:sir6_mouse(display_long)|uniprotkb:Sirt6(gene name)|psi-mi:Sirt6(display_short)|uniprotkb:Sir2l6(gene name synonym)|uniprotkb:SIR2-like protein 6(gene name synonym)|uniprotkb:Regulatory protein SIR2 homolog 6(gene name synonym)	psi-mi:"MI:0402"(chromatin immunoprecipitation assay)	Kawahara et al. (2009)	imex:IM-12156|pubmed:19135889	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2213935|imex:IM-12156-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0250"(gene)	psi-mi:"MI:0326"(protein)	-	refseq:NP_853617.1|ensembl:ENSMUSG00000034748(gene)|ensembl:ENSMUST00000042923(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003247"(post-embryonic cardiac muscle cell growth involved in heart morphogenesis)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003956"("NAD(P)+-protein-arginine ADP-ribosyltransferase activity")|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006284"(base-excision repair)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010569"(regulation of double-strand break repair via homologous recombination)|go:"GO:0017136"(NAD-dependent histone deacetylase activity)|go:"GO:0019213"(deacetylase activity)|go:"GO:0031648"(protein destabilization)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0031940"(obsolete positive regulation of chromatin silencing at telomere)|go:"GO:0032206"(positive regulation of telomere maintenance)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0046969"("NAD-dependent histone deacetylase activity (H3-K9 specific)")|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0070403"(NAD+ binding)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0099115"(chromosome, subtelomeric region)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1901485"(positive regulation of transcription factor catabolic process)|go:"GO:1902732"(positive regulation of chondrocyte proliferation)|go:"GO:1905549"(obsolete positive regulation of subtelomeric heterochromatin assembly)|go:"GO:1905555"(positive regulation of blood vessel branching)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR003000(NAD-dependent histone deacetylase, silent information regulator Sir2)|interpro:IPR026590|interpro:IPR029035|reactome:R-MMU-5693607	-	-	-	figure legend:Supp. Fig. 3|comment:Interaction was not observed in Rela -/- cells|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-embryonic_fibroblast)|taxid:10090(Mus musculus embryonic fibroblasts)	-	2009/01/27	2014/10/16	-	rogid:aa94tMFcxF2sGVOsaTEmfv5O+xg10090	intact-crc:A5A542DE15931944	false	-	-	-	-	psi-mi:"MI:0088"(primer specific pcr)	psi-mi:"MI:0088"(primer specific pcr)