#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P32797	uniprotkb:P00546	intact:EBI-4187|uniprotkb:Q07650|uniprotkb:D6VRD4|ensemblfungi:YDL220C	intact:EBI-4253|uniprotkb:D6VQF5|ensemblfungi:YBR160W	psi-mi:cdc13_yeast(display_long)|uniprotkb:CDC13(gene name)|psi-mi:CDC13(display_short)|uniprotkb:YDL220C(locus name)	psi-mi:cdk1_yeast(display_long)|uniprotkb:CDC28(gene name)|psi-mi:CDC28(display_short)|uniprotkb:CDK1(gene name synonym)|uniprotkb:HSL5(gene name synonym)|uniprotkb:SRM5(gene name synonym)|uniprotkb:YBR1211(orf name)|uniprotkb:YBR160W(locus name)|uniprotkb:Cell division control protein 28(gene name synonym)|uniprotkb:Cell division protein kinase 1(gene name synonym)	psi-mi:"MI:0424"(protein kinase assay)	Li et al. (2009)	imex:IM-12155|pubmed:19135888	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0217"(phosphorylation reaction)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2213449|imex:IM-12155-1	-	-	psi-mi:"MI:0502"(enzyme target)	psi-mi:"MI:0501"(enzyme)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_010061.1|sgd:S000002379|dip:DIP-1229N|mint:P32797|ensemblfungi:YDL220C(gene)|ensemblfungi:YDL220C_mRNA(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000783"(nuclear telomere cap complex)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0007049"(cell cycle)|go:"GO:0010521"(telomerase inhibitor activity)|go:"GO:0016233"(telomere capping)|go:"GO:0032210"(regulation of telomere maintenance via telomerase)|go:"GO:0042802"(identical protein binding)|go:"GO:0043047"(single-stranded telomeric DNA binding)|go:"GO:0051301"(cell division)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0061770"(translation elongation factor binding)|go:"GO:0071166"(ribonucleoprotein complex localization)|go:"GO:0098505"(G-rich strand telomeric DNA binding)|go:"GO:1990879"(CST complex)|interpro:IPR011564(Telomere end binding protein)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR028389|interpro:IPR031749|interpro:IPR040650|interpro:IPR041028|rcsb pdb:1KXL|rcsb pdb:1S40|rcsb pdb:3NWS|rcsb pdb:3NWT|rcsb pdb:3OIP|rcsb pdb:3OIQ|rcsb pdb:4HCE	sgd:S000000364|refseq:NP_009718.3|dip:DIP-1039N|mint:P00546|ensemblfungi:YBR160W(gene)|ensemblfungi:YBR160W_mRNA(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0000706"(meiotic DNA double-strand break processing)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000729"(DNA double-strand break processing)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004693"(cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005935"(cellular bud neck)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0006370"(7-methylguanosine mRNA capping)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006892"(post-Golgi vesicle-mediated transport)|go:"GO:0007130"(synaptonemal complex assembly)|go:"GO:0007165"(signal transduction)|go:"GO:0010389"(regulation of G2/M transition of mitotic cell cycle)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010568"(regulation of budding cell apical bud growth)|go:"GO:0010570"(regulation of filamentous growth)|go:"GO:0010571"(positive regulation of nuclear cell cycle DNA replication)|go:"GO:0010696"(positive regulation of mitotic spindle pole body separation)|go:"GO:0010898"(positive regulation of triglyceride catabolic process)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0030332"(cyclin binding)|go:"GO:0032210"(regulation of telomere maintenance via telomerase)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0042393"(histone binding)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0045819"(positive regulation of glycogen catabolic process)|go:"GO:0045875"(negative regulation of sister chromatid cohesion)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045930"(negative regulation of mitotic cell cycle)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051301"(cell division)|go:"GO:0051446"(positive regulation of meiotic cell cycle)|go:"GO:0051447"(negative regulation of meiotic cell cycle)|go:"GO:0060303"(regulation of nucleosome density)|go:"GO:0070816"(phosphorylation of RNA polymerase II C-terminal domain)|go:"GO:0090169"(regulation of spindle assembly)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901319"(positive regulation of trehalose catabolic process)|go:"GO:1902596"(negative regulation of DNA replication origin binding)|go:"GO:1902889"(protein localization to spindle microtubule)|go:"GO:1903500"(negative regulation of mitotic actomyosin contractile ring assembly)|go:"GO:1903827"|go:"GO:1904291"(positive regulation of mitotic DNA damage checkpoint)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|go:"GO:1905634"(regulation of protein localization to chromatin)|go:"GO:1990139"(protein localization to nuclear periphery)|go:"GO:1990758"(mitotic sister chromatid biorientation)|go:"GO:2001033"(negative regulation of double-strand break repair via nonhomologous end joining)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|reactome:R-SCE-68949|reactome:R-SCE-68962|reactome:R-SCE-69017|reactome:R-SCE-69202|reactome:R-SCE-69656	go:"GO:0004672"(protein kinase activity)|go:"GO:0006468"(protein phosphorylation)	crc64:9FE0AD08520A6F8A	crc64:57A7A2B97A90DC6C	figure legend:Figs. 1C, 1D, 1E|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/01/27	2014/10/16	rogid:gEY0/HOYDHm74lrl6CSs1ZGNpkA559292	rogid:gYjsHsmOYQGGIVjiQ/ZH+BB9BCM559292	intact-crc:1BABA912286AA9DB|rigid:S+LKk0vTmQdEmGL1F5A78IwpTC4	false	his tag:?-?|mutation disrupting interaction:711-711,708-708,460-460,336-336,110-110,650-650,308-308|mutation decreasing interaction:308-308|mutation disrupting interaction:308-308,336-336	calmodulin binding peptide plus protein a tag:?-?	-	-	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)	psi-mi:"MI:0821"(molecular weight estimation by autoradiography)
uniprotkb:P17214	uniprotkb:P32797	intact:EBI-6684|uniprotkb:Q05997|uniprotkb:D6VYN3|ensemblfungi:YLR233C	intact:EBI-4187|uniprotkb:Q07650|uniprotkb:D6VRD4|ensemblfungi:YDL220C	psi-mi:est1_yeast(display_long)|uniprotkb:EST1(gene name)|psi-mi:EST1(display_short)|uniprotkb:YLR233C(locus name)|uniprotkb:L8083.15(orf name)|uniprotkb:Ever shorter telomeres protein 1(gene name synonym)	psi-mi:cdc13_yeast(display_long)|uniprotkb:CDC13(gene name)|psi-mi:CDC13(display_short)|uniprotkb:YDL220C(locus name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Li et al. (2009)	imex:IM-12155|pubmed:19135888	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2213484|imex:IM-12155-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_013334.1|sgd:S000004223|reactome:R-SCE-975957|dip:DIP-1306N|ensemblfungi:YLR233C(gene)|ensemblfungi:YLR233C_mRNA(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005697"(telomerase holoenzyme complex)|go:"GO:0005730"(nucleolus)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0032210"(regulation of telomere maintenance via telomerase)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0071919"(G-quadruplex DNA formation)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR018834|interpro:IPR019458	refseq:NP_010061.1|sgd:S000002379|dip:DIP-1229N|mint:P32797|ensemblfungi:YDL220C(gene)|ensemblfungi:YDL220C_mRNA(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000783"(nuclear telomere cap complex)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0007049"(cell cycle)|go:"GO:0010521"(telomerase inhibitor activity)|go:"GO:0016233"(telomere capping)|go:"GO:0032210"(regulation of telomere maintenance via telomerase)|go:"GO:0042802"(identical protein binding)|go:"GO:0043047"(single-stranded telomeric DNA binding)|go:"GO:0051301"(cell division)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0061770"(translation elongation factor binding)|go:"GO:0071166"(ribonucleoprotein complex localization)|go:"GO:0098505"(G-rich strand telomeric DNA binding)|go:"GO:1990879"(CST complex)|interpro:IPR011564(Telomere end binding protein)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR028389|interpro:IPR031749|interpro:IPR040650|interpro:IPR041028|rcsb pdb:1KXL|rcsb pdb:1S40|rcsb pdb:3NWS|rcsb pdb:3NWT|rcsb pdb:3OIP|rcsb pdb:3OIQ|rcsb pdb:4HCE	psi-mi:"MI:0469"(intact)	crc64:9CF552AFDA6BDEDE	crc64:9FE0AD08520A6F8A	comment:Est1 must be over-expressed for this interaction to be observed.|figure legend:Fig. 4B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2009/01/27	2014/10/16	rogid:hu3SMHhlU1yKF9bVHdYQucREmxQ559292	rogid:gEY0/HOYDHm74lrl6CSs1ZGNpkA559292	intact-crc:7F9591D5CA60AC7F|rigid:++fVI3zNEeGxaJypbg9ULkbpDGE	false	myc tag:?-?	ha tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P38960	uniprotkb:P32797	intact:EBI-18427|uniprotkb:D6VS69|ensemblfungi:YDR082W	intact:EBI-4187|uniprotkb:Q07650|uniprotkb:D6VRD4|ensemblfungi:YDL220C	psi-mi:stn1_yeast(display_long)|uniprotkb:STN1(gene name)|psi-mi:STN1(display_short)|uniprotkb:D4456(orf name)|uniprotkb:YD8554.15(orf name)|uniprotkb:YDR082W(locus name)	psi-mi:cdc13_yeast(display_long)|uniprotkb:CDC13(gene name)|psi-mi:CDC13(display_short)|uniprotkb:YDL220C(locus name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Li et al. (2009)	imex:IM-12155|pubmed:19135888	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2213494|imex:IM-12155-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_010367.1|sgd:S000002489|ensemblfungi:YDR082W(gene)|ensemblfungi:YDR082W_mRNA(transcript)|go:"GO:0016233"(telomere capping)|go:"GO:0032211"(negative regulation of telomere maintenance via telomerase)|go:"GO:0043047"(single-stranded telomeric DNA binding)|go:"GO:0061770"(translation elongation factor binding)|go:"GO:1990879"(CST complex)|interpro:IPR018856|interpro:IPR024263|interpro:IPR038240|rcsb pdb:3K10|rcsb pdb:3KEY|dip:DIP-1230N	refseq:NP_010061.1|sgd:S000002379|dip:DIP-1229N|mint:P32797|ensemblfungi:YDL220C(gene)|ensemblfungi:YDL220C_mRNA(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000783"(nuclear telomere cap complex)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0007049"(cell cycle)|go:"GO:0010521"(telomerase inhibitor activity)|go:"GO:0016233"(telomere capping)|go:"GO:0032210"(regulation of telomere maintenance via telomerase)|go:"GO:0042802"(identical protein binding)|go:"GO:0043047"(single-stranded telomeric DNA binding)|go:"GO:0051301"(cell division)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0061770"(translation elongation factor binding)|go:"GO:0071166"(ribonucleoprotein complex localization)|go:"GO:0098505"(G-rich strand telomeric DNA binding)|go:"GO:1990879"(CST complex)|interpro:IPR011564(Telomere end binding protein)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR028389|interpro:IPR031749|interpro:IPR040650|interpro:IPR041028|rcsb pdb:1KXL|rcsb pdb:1S40|rcsb pdb:3NWS|rcsb pdb:3NWT|rcsb pdb:3OIP|rcsb pdb:3OIQ|rcsb pdb:4HCE	psi-mi:"MI:0469"(intact)	crc64:61B691C8D4A2E650	crc64:9FE0AD08520A6F8A	comment:Stn1 must be over-expressed for this interaction to be observed.|figure legend:Fig. 4B|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2009/01/27	2014/10/16	rogid:ARXyD+3sq7/gT0WnA5whhA5eIsA559292	rogid:gEY0/HOYDHm74lrl6CSs1ZGNpkA559292	intact-crc:7BF7FA0CA24F6266|rigid:Nxgp0CSBeiwJxzy1fP7Nl1JvXFA	false	myc tag:?-?	ha tag:?-?	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
intact:EBI-2213511	uniprotkb:P32797	rnacentral:URS0000348061_559292	intact:EBI-4187|uniprotkb:Q07650|uniprotkb:D6VRD4|ensemblfungi:YDL220C	psi-mi:tlc1_yeast_rna(display_short)|psi-mi:EBI-2213511(display_long)	psi-mi:cdc13_yeast(display_long)|uniprotkb:CDC13(gene name)|psi-mi:CDC13(display_short)|uniprotkb:YDL220C(locus name)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Li et al. (2009)	imex:IM-12155|pubmed:19135888	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2213520|imex:IM-12155-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0320"(ribonucleic acid)	psi-mi:"MI:0326"(protein)	sgd:S000006657(see-also)	refseq:NP_010061.1|sgd:S000002379|dip:DIP-1229N|mint:P32797|ensemblfungi:YDL220C(gene)|ensemblfungi:YDL220C_mRNA(transcript)|go:"GO:0000723"(telomere maintenance)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000783"(nuclear telomere cap complex)|go:"GO:0007004"(telomere maintenance via telomerase)|go:"GO:0007049"(cell cycle)|go:"GO:0010521"(telomerase inhibitor activity)|go:"GO:0016233"(telomere capping)|go:"GO:0032210"(regulation of telomere maintenance via telomerase)|go:"GO:0042802"(identical protein binding)|go:"GO:0043047"(single-stranded telomeric DNA binding)|go:"GO:0051301"(cell division)|go:"GO:0051974"(negative regulation of telomerase activity)|go:"GO:0061770"(translation elongation factor binding)|go:"GO:0071166"(ribonucleoprotein complex localization)|go:"GO:0098505"(G-rich strand telomeric DNA binding)|go:"GO:1990879"(CST complex)|interpro:IPR011564(Telomere end binding protein)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|interpro:IPR028389|interpro:IPR031749|interpro:IPR040650|interpro:IPR041028|rcsb pdb:1KXL|rcsb pdb:1S40|rcsb pdb:3NWS|rcsb pdb:3NWT|rcsb pdb:3OIP|rcsb pdb:3OIQ|rcsb pdb:4HCE	-	comment:"TLC1 RNA contains a template sequence that Est2p uses to add irregular repeats of TG(1-3) residues onto a DNA end; RNA template component of telomerase"	crc64:9FE0AD08520A6F8A	figure legend:Fig. 4C, 5B, 6C|comment:Interaction is increased in cells lacking rif1 or rif2 - this effect is decreased by the thr308ala mutation to cdc13. The interaction is also increased in cells expressing Stn1 which has the C terminus necessary for its interaction with Cdc13 deleted, this is not effected by the thr308ala mutation.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2009/01/27	2016/03/18	-	rogid:gEY0/HOYDHm74lrl6CSs1ZGNpkA559292	intact-crc:7DDD8641A655B7E0	false	-	ha tag:?-?|mutation decreasing interaction:308-308	-	-	psi-mi:"MI:0088"(primer specific pcr)	psi-mi:"MI:0088"(primer specific pcr)