#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:A4GZ26	uniprotkb:Q8BKX1	intact:EBI-8526464|intact:MINT-7232686|ensembl:ENSMUSP00000127249	intact:EBI-771498|uniprotkb:Q91V97|uniprotkb:Q923V9|uniprotkb:Q923W0|ensembl:ENSMUSP00000026436	psi-mi:a4gz26_mouse(display_long)|uniprotkb:Iqsec2(gene name)|psi-mi:Iqsec2(display_short)|uniprotkb:IQArfGEF(gene name synonym)	psi-mi:baip2_mouse(display_long)|uniprotkb:Insulin receptor tyrosine kinase 53 kDa substrate(gene name synonym)|uniprotkb:Insulin receptor substrate protein of 53 kDa(gene name synonym)|uniprotkb:Baiap2(gene name)|psi-mi:Baiap2(display_short)	psi-mi:"MI:0018"(two hybrid)	Sanda et al. (2009)	mint:MINT-7215336|pubmed:19083995|doi:10.1016/j.brainres.2008.11.061	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8526458|mint:MINT-7232700	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001108136.1|ensembl:ENSMUSG00000041115(gene)|ensembl:ENSMUST00000168786(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0032012"(regulation of ARF protein signal transduction)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR000904(SEC7-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR023394|interpro:IPR033742|interpro:IPR035999|mint:A4GZ26|mint:MINT-7232702(identity)	refseq:NP_001032843.1|refseq:NP_001032844.2|refseq:NP_570932.2|ensembl:ENSMUSG00000025372(gene)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0001726"(ruffle)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0007009"(plasma membrane organization)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0007420"(brain development)|go:"GO:0008093"(cytoskeletal anchor activity)|ensembl:ENSMUST00000026436(transcript)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009617"(response to bacterium)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016358"(dendrite development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030141"(secretory granule)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030175"(filopodium)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0051764"(actin crosslink formation)|go:"GO:0060076"(excitatory synapse)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0061845"(neuron projection branch point)|go:"GO:0061846"(dendritic spine cytoplasm)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099564"(modification of synaptic structure, modulating synaptic transmission)|go:"GO:1905232"(cellular response to L-glutamate)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|interpro:IPR001452(Src homology-3)|interpro:IPR013606("IRSp53/MIM homology domain (IMD)")|interpro:IPR027267|interpro:IPR027681|interpro:IPR030128|interpro:IPR035594|interpro:IPR036028|mint:Q8BKX1|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013423|dip:DIP-32392N|mint:MINT-7232703(identity)	-	comment:mint	-	figure legend:f1a|comment:homomint|comment:mint|partial coverage:partial coverage|curation depth:mimix curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2009/07/24	2014/10/16	rogid:Q5seAZYl6EgyG0cl/AMiAXLZUc810090	rogid:wJuf0b5jAqz/124eflke8AE+Ue410090	intact-crc:EF0C70618B8C99A7|rigid:6bwMcV9NxSTRV2PB9g/vz/vcm6U	false	binding-associated region:1198-1479(MINT-7232710)	binding-associated region:37-522(MINT-7232706)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:A4GZ26	uniprotkb:Q8BKX1	intact:EBI-8526464|intact:MINT-7232686|ensembl:ENSMUSP00000127249	intact:EBI-771498|uniprotkb:Q91V97|uniprotkb:Q923V9|uniprotkb:Q923W0|ensembl:ENSMUSP00000026436	psi-mi:a4gz26_mouse(display_long)|uniprotkb:Iqsec2(gene name)|psi-mi:Iqsec2(display_short)|uniprotkb:IQArfGEF(gene name synonym)	psi-mi:baip2_mouse(display_long)|uniprotkb:Insulin receptor tyrosine kinase 53 kDa substrate(gene name synonym)|uniprotkb:Insulin receptor substrate protein of 53 kDa(gene name synonym)|uniprotkb:Baiap2(gene name)|psi-mi:Baiap2(display_short)	psi-mi:"MI:0018"(two hybrid)	Sanda et al. (2009)	mint:MINT-7215336|pubmed:19083995|doi:10.1016/j.brainres.2008.11.061	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8526495|mint:MINT-7232812	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001108136.1|ensembl:ENSMUSG00000041115(gene)|ensembl:ENSMUST00000168786(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0032012"(regulation of ARF protein signal transduction)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR000904(SEC7-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR023394|interpro:IPR033742|interpro:IPR035999|mint:A4GZ26|mint:MINT-7232814(identity)	refseq:NP_001032843.1|refseq:NP_001032844.2|refseq:NP_570932.2|ensembl:ENSMUSG00000025372(gene)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0001726"(ruffle)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0007009"(plasma membrane organization)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0007420"(brain development)|go:"GO:0008093"(cytoskeletal anchor activity)|ensembl:ENSMUST00000026436(transcript)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009617"(response to bacterium)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016358"(dendrite development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030141"(secretory granule)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030175"(filopodium)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0051764"(actin crosslink formation)|go:"GO:0060076"(excitatory synapse)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0061845"(neuron projection branch point)|go:"GO:0061846"(dendritic spine cytoplasm)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099564"(modification of synaptic structure, modulating synaptic transmission)|go:"GO:1905232"(cellular response to L-glutamate)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|interpro:IPR001452(Src homology-3)|interpro:IPR013606("IRSp53/MIM homology domain (IMD)")|interpro:IPR027267|interpro:IPR027681|interpro:IPR030128|interpro:IPR035594|interpro:IPR036028|mint:Q8BKX1|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013423|dip:DIP-32392N|mint:MINT-7232821(identity)	-	comment:mint	-	figure legend:f3b|comment:homomint|comment:mint|partial coverage:partial coverage|curation depth:mimix curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2009/07/24	2014/10/16	rogid:Q5seAZYl6EgyG0cl/AMiAXLZUc810090	rogid:wJuf0b5jAqz/124eflke8AE+Ue410090	intact-crc:9ACC18A7E10B8012|rigid:6bwMcV9NxSTRV2PB9g/vz/vcm6U	false	mutation disrupting interaction:1433-1433(MINT-7232844)|mutation disrupting interaction:1434-1434(MINT-7232846)|binding-associated region:1424-1434(MINT-7232817)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:A4GZ26	uniprotkb:Q8BKX1	intact:EBI-8526464|intact:MINT-7232686|ensembl:ENSMUSP00000127249	intact:EBI-771498|uniprotkb:Q91V97|uniprotkb:Q923V9|uniprotkb:Q923W0|ensembl:ENSMUSP00000026436	psi-mi:a4gz26_mouse(display_long)|uniprotkb:Iqsec2(gene name)|psi-mi:Iqsec2(display_short)|uniprotkb:IQArfGEF(gene name synonym)	psi-mi:baip2_mouse(display_long)|uniprotkb:Insulin receptor tyrosine kinase 53 kDa substrate(gene name synonym)|uniprotkb:Insulin receptor substrate protein of 53 kDa(gene name synonym)|uniprotkb:Baiap2(gene name)|psi-mi:Baiap2(display_short)	psi-mi:"MI:0096"(pull down)	Sanda et al. (2009)	mint:MINT-7215336|pubmed:19083995|doi:10.1016/j.brainres.2008.11.061	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8526552|mint:MINT-7232771	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001108136.1|ensembl:ENSMUSG00000041115(gene)|ensembl:ENSMUST00000168786(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0032012"(regulation of ARF protein signal transduction)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR000904(SEC7-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR023394|interpro:IPR033742|interpro:IPR035999|mint:A4GZ26|mint:MINT-7232773(identity)	refseq:NP_001032843.1|refseq:NP_001032844.2|refseq:NP_570932.2|ensembl:ENSMUSG00000025372(gene)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0001726"(ruffle)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0007009"(plasma membrane organization)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0007420"(brain development)|go:"GO:0008093"(cytoskeletal anchor activity)|ensembl:ENSMUST00000026436(transcript)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009617"(response to bacterium)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016358"(dendrite development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030141"(secretory granule)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030175"(filopodium)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0051764"(actin crosslink formation)|go:"GO:0060076"(excitatory synapse)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0061845"(neuron projection branch point)|go:"GO:0061846"(dendritic spine cytoplasm)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099564"(modification of synaptic structure, modulating synaptic transmission)|go:"GO:1905232"(cellular response to L-glutamate)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|interpro:IPR001452(Src homology-3)|interpro:IPR013606("IRSp53/MIM homology domain (IMD)")|interpro:IPR027267|interpro:IPR027681|interpro:IPR030128|interpro:IPR035594|interpro:IPR036028|mint:Q8BKX1|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013423|dip:DIP-32392N|mint:MINT-7232775(identity)	-	comment:mint	-	figure legend:f2b|comment:homomint|comment:mint|partial coverage:partial coverage|curation depth:mimix curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/07/24	2014/10/16	rogid:Q5seAZYl6EgyG0cl/AMiAXLZUc810090	rogid:wJuf0b5jAqz/124eflke8AE+Ue410090	intact-crc:FF91CD3F76FBA60A|rigid:6bwMcV9NxSTRV2PB9g/vz/vcm6U	false	binding-associated region:1198-1479(MINT-7232782)|glutathione s tranferase tag:?-?(MINT-7232780)	green fluorescent protein tag:?-?(MINT-7232786)|binding-associated region:372-442(MINT-7232788)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:A4GZ26	uniprotkb:Q8BKX1	intact:EBI-8526464|intact:MINT-7232686|ensembl:ENSMUSP00000127249	intact:EBI-771498|uniprotkb:Q91V97|uniprotkb:Q923V9|uniprotkb:Q923W0|ensembl:ENSMUSP00000026436	psi-mi:a4gz26_mouse(display_long)|uniprotkb:Iqsec2(gene name)|psi-mi:Iqsec2(display_short)|uniprotkb:IQArfGEF(gene name synonym)	psi-mi:baip2_mouse(display_long)|uniprotkb:Insulin receptor tyrosine kinase 53 kDa substrate(gene name synonym)|uniprotkb:Insulin receptor substrate protein of 53 kDa(gene name synonym)|uniprotkb:Baiap2(gene name)|psi-mi:Baiap2(display_short)	psi-mi:"MI:0096"(pull down)	Sanda et al. (2009)	mint:MINT-7215336|pubmed:19083995|doi:10.1016/j.brainres.2008.11.061	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8526531|mint:MINT-7232713	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001108136.1|ensembl:ENSMUSG00000041115(gene)|ensembl:ENSMUST00000168786(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0032012"(regulation of ARF protein signal transduction)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR000904(SEC7-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR023394|interpro:IPR033742|interpro:IPR035999|mint:A4GZ26|mint:MINT-7232719(identity)	refseq:NP_001032843.1|refseq:NP_001032844.2|refseq:NP_570932.2|ensembl:ENSMUSG00000025372(gene)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0001726"(ruffle)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0007009"(plasma membrane organization)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0007420"(brain development)|go:"GO:0008093"(cytoskeletal anchor activity)|ensembl:ENSMUST00000026436(transcript)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009617"(response to bacterium)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016358"(dendrite development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030141"(secretory granule)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030175"(filopodium)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0051764"(actin crosslink formation)|go:"GO:0060076"(excitatory synapse)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0061845"(neuron projection branch point)|go:"GO:0061846"(dendritic spine cytoplasm)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099564"(modification of synaptic structure, modulating synaptic transmission)|go:"GO:1905232"(cellular response to L-glutamate)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|interpro:IPR001452(Src homology-3)|interpro:IPR013606("IRSp53/MIM homology domain (IMD)")|interpro:IPR027267|interpro:IPR027681|interpro:IPR030128|interpro:IPR035594|interpro:IPR036028|mint:Q8BKX1|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013423|dip:DIP-32392N|mint:MINT-7232715(identity)	-	comment:mint	-	figure legend:f1b|comment:homomint|comment:mint|partial coverage:partial coverage|curation depth:mimix curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/07/24	2014/10/16	rogid:Q5seAZYl6EgyG0cl/AMiAXLZUc810090	rogid:wJuf0b5jAqz/124eflke8AE+Ue410090	intact-crc:78D676F2B0584FC7|rigid:6bwMcV9NxSTRV2PB9g/vz/vcm6U	false	binding-associated region:1198-1479(MINT-7232720)|glutathione s tranferase tag:?-?(MINT-7232728)	myc tag:?-?(MINT-7232731)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:A4GZ26	uniprotkb:Q8BKX1	intact:EBI-8526464|intact:MINT-7232686|ensembl:ENSMUSP00000127249	intact:EBI-771498|uniprotkb:Q91V97|uniprotkb:Q923V9|uniprotkb:Q923W0|ensembl:ENSMUSP00000026436	psi-mi:a4gz26_mouse(display_long)|uniprotkb:Iqsec2(gene name)|psi-mi:Iqsec2(display_short)|uniprotkb:IQArfGEF(gene name synonym)	psi-mi:baip2_mouse(display_long)|uniprotkb:Insulin receptor tyrosine kinase 53 kDa substrate(gene name synonym)|uniprotkb:Insulin receptor substrate protein of 53 kDa(gene name synonym)|uniprotkb:Baiap2(gene name)|psi-mi:Baiap2(display_short)	psi-mi:"MI:0096"(pull down)	Sanda et al. (2009)	mint:MINT-7215336|pubmed:19083995|doi:10.1016/j.brainres.2008.11.061	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8526578|mint:MINT-7232792	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001108136.1|ensembl:ENSMUSG00000041115(gene)|ensembl:ENSMUST00000168786(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0032012"(regulation of ARF protein signal transduction)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR000904(SEC7-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR023394|interpro:IPR033742|interpro:IPR035999|mint:A4GZ26|mint:MINT-7232801(identity)	refseq:NP_001032843.1|refseq:NP_001032844.2|refseq:NP_570932.2|ensembl:ENSMUSG00000025372(gene)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0001726"(ruffle)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0007009"(plasma membrane organization)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0007420"(brain development)|go:"GO:0008093"(cytoskeletal anchor activity)|ensembl:ENSMUST00000026436(transcript)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009617"(response to bacterium)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016358"(dendrite development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030141"(secretory granule)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030175"(filopodium)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0051764"(actin crosslink formation)|go:"GO:0060076"(excitatory synapse)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0061845"(neuron projection branch point)|go:"GO:0061846"(dendritic spine cytoplasm)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099564"(modification of synaptic structure, modulating synaptic transmission)|go:"GO:1905232"(cellular response to L-glutamate)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|interpro:IPR001452(Src homology-3)|interpro:IPR013606("IRSp53/MIM homology domain (IMD)")|interpro:IPR027267|interpro:IPR027681|interpro:IPR030128|interpro:IPR035594|interpro:IPR036028|mint:Q8BKX1|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013423|dip:DIP-32392N|mint:MINT-7232794(identity)	-	comment:mint	-	figure legend:f3b|comment:homomint|comment:mint|partial coverage:partial coverage|curation depth:mimix curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/07/24	2014/10/16	rogid:Q5seAZYl6EgyG0cl/AMiAXLZUc810090	rogid:wJuf0b5jAqz/124eflke8AE+Ue410090	intact-crc:FEE75BB59FD4BDE2|rigid:6bwMcV9NxSTRV2PB9g/vz/vcm6U	false	mutation disrupting interaction:1433-1433(MINT-7232837)|binding-associated region:1424-1434(MINT-7232802)|mutation disrupting interaction:1434-1434(MINT-7232840)|glutathione s tranferase tag:?-?(MINT-7232805)	green fluorescent protein tag:?-?(MINT-7232798)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:A4GZ26	uniprotkb:Q8BKX1	intact:EBI-8526464|intact:MINT-7232686|ensembl:ENSMUSP00000127249	intact:EBI-771498|uniprotkb:Q91V97|uniprotkb:Q923V9|uniprotkb:Q923W0|ensembl:ENSMUSP00000026436	psi-mi:a4gz26_mouse(display_long)|uniprotkb:Iqsec2(gene name)|psi-mi:Iqsec2(display_short)|uniprotkb:IQArfGEF(gene name synonym)	psi-mi:baip2_mouse(display_long)|uniprotkb:Insulin receptor tyrosine kinase 53 kDa substrate(gene name synonym)|uniprotkb:Insulin receptor substrate protein of 53 kDa(gene name synonym)|uniprotkb:Baiap2(gene name)|psi-mi:Baiap2(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Sanda et al. (2009)	mint:MINT-7215336|pubmed:19083995|doi:10.1016/j.brainres.2008.11.061	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8526620|mint:MINT-7232735	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001108136.1|ensembl:ENSMUSG00000041115(gene)|ensembl:ENSMUST00000168786(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0032012"(regulation of ARF protein signal transduction)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR000904(SEC7-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR023394|interpro:IPR033742|interpro:IPR035999|mint:A4GZ26|mint:MINT-7232737(identity)	refseq:NP_001032843.1|refseq:NP_001032844.2|refseq:NP_570932.2|ensembl:ENSMUSG00000025372(gene)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0001726"(ruffle)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0007009"(plasma membrane organization)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0007420"(brain development)|go:"GO:0008093"(cytoskeletal anchor activity)|ensembl:ENSMUST00000026436(transcript)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009617"(response to bacterium)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016358"(dendrite development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030141"(secretory granule)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030175"(filopodium)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0051764"(actin crosslink formation)|go:"GO:0060076"(excitatory synapse)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0061845"(neuron projection branch point)|go:"GO:0061846"(dendritic spine cytoplasm)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099564"(modification of synaptic structure, modulating synaptic transmission)|go:"GO:1905232"(cellular response to L-glutamate)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|interpro:IPR001452(Src homology-3)|interpro:IPR013606("IRSp53/MIM homology domain (IMD)")|interpro:IPR027267|interpro:IPR027681|interpro:IPR030128|interpro:IPR035594|interpro:IPR036028|mint:Q8BKX1|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013423|dip:DIP-32392N|mint:MINT-7232743(identity)	-	comment:mint	-	figure legend:f1c|comment:homomint|comment:mint|partial coverage:partial coverage|curation depth:mimix curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2009/07/24	2014/10/16	rogid:Q5seAZYl6EgyG0cl/AMiAXLZUc810090	rogid:wJuf0b5jAqz/124eflke8AE+Ue410090	intact-crc:5BEDFEC700DBE522|rigid:6bwMcV9NxSTRV2PB9g/vz/vcm6U	false	flag tag:?-?(MINT-7232738)	myc tag:?-?(MINT-7232744)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:A4GZ26	uniprotkb:Q8BKX1	intact:EBI-8526464|intact:MINT-7232686|ensembl:ENSMUSP00000127249	intact:EBI-771498|uniprotkb:Q91V97|uniprotkb:Q923V9|uniprotkb:Q923W0|ensembl:ENSMUSP00000026436	psi-mi:a4gz26_mouse(display_long)|uniprotkb:Iqsec2(gene name)|psi-mi:Iqsec2(display_short)|uniprotkb:IQArfGEF(gene name synonym)	psi-mi:baip2_mouse(display_long)|uniprotkb:Insulin receptor tyrosine kinase 53 kDa substrate(gene name synonym)|uniprotkb:Insulin receptor substrate protein of 53 kDa(gene name synonym)|uniprotkb:Baiap2(gene name)|psi-mi:Baiap2(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Sanda et al. (2009)	mint:MINT-7215336|pubmed:19083995|doi:10.1016/j.brainres.2008.11.061	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8526650|mint:MINT-7232754	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001108136.1|ensembl:ENSMUSG00000041115(gene)|ensembl:ENSMUST00000168786(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0032012"(regulation of ARF protein signal transduction)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR000904(SEC7-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR023394|interpro:IPR033742|interpro:IPR035999|mint:A4GZ26|mint:MINT-7232760(identity)	refseq:NP_001032843.1|refseq:NP_001032844.2|refseq:NP_570932.2|ensembl:ENSMUSG00000025372(gene)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0001726"(ruffle)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0007009"(plasma membrane organization)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0007420"(brain development)|go:"GO:0008093"(cytoskeletal anchor activity)|ensembl:ENSMUST00000026436(transcript)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009617"(response to bacterium)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016358"(dendrite development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030141"(secretory granule)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030175"(filopodium)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0035418"(protein localization to synapse)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)|go:"GO:0044306"(neuron projection terminus)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0051764"(actin crosslink formation)|go:"GO:0060076"(excitatory synapse)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0061845"(neuron projection branch point)|go:"GO:0061846"(dendritic spine cytoplasm)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099564"(modification of synaptic structure, modulating synaptic transmission)|go:"GO:1905232"(cellular response to L-glutamate)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|interpro:IPR001452(Src homology-3)|interpro:IPR013606("IRSp53/MIM homology domain (IMD)")|interpro:IPR027267|interpro:IPR027681|interpro:IPR030128|interpro:IPR035594|interpro:IPR036028|mint:Q8BKX1|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013423|dip:DIP-32392N|mint:MINT-7232756(identity)	-	comment:mint	-	figure legend:f1d|comment:homomint|comment:mint|partial coverage:partial coverage|curation depth:mimix curation	taxid:10090(mouse)|taxid:10090(Mus musculus)	-	2009/07/24	2014/10/16	rogid:Q5seAZYl6EgyG0cl/AMiAXLZUc810090	rogid:wJuf0b5jAqz/124eflke8AE+Ue410090	intact-crc:4BC5847BDA4EBB33|rigid:6bwMcV9NxSTRV2PB9g/vz/vcm6U	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)