#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q13616	uniprotkb:Q9WTZ1	intact:EBI-359390|uniprotkb:O60719|uniprotkb:Q08AL6|uniprotkb:Q8IYW1|uniprotkb:D3DWG3|ensembl:ENSP00000326804|ensembl:ENSP00000387160|ensembl:ENSP00000473318|ensembl:ENSP00000499255|ensembl:ENSP00000499277|ensembl:ENSP00000499398	intact:EBI-2659373|uniprotkb:Q3UKF8|ensembl:ENSMUSP00000052856	psi-mi:cul1_human(display_long)|uniprotkb:CUL1(gene name)|psi-mi:CUL1(display_short)	psi-mi:rbx2_mouse(display_long)|uniprotkb:RING finger protein 7(gene name synonym)|uniprotkb:Sensitive to apoptosis gene protein(gene name synonym)|uniprotkb:Rbx2(gene name synonym)|uniprotkb:Sag(gene name synonym)|uniprotkb:Rnf7(gene name)|psi-mi:Rnf7(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Yasukawa et al. (2008)	mint:MINT-7277467|pubmed:19037258|imex:IM-13833|doi:10.1038/emboj.2008.249	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8508137|mint:MINT-7277510|imex:IM-13833-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003583.2|rcsb pdb:6WCQ|rcsb pdb:7B5L|rcsb pdb:7B5M|rcsb pdb:7B5N|rcsb pdb:7B5R|rcsb pdb:7B5S|reactome:R-HSA-1169091|reactome:R-HSA-1170546|reactome:R-HSA-174113|reactome:R-HSA-187577|reactome:R-HSA-195253|reactome:R-HSA-202424|reactome:R-HSA-2122947|reactome:R-HSA-2565942|reactome:R-HSA-2644606|reactome:R-HSA-2644607|reactome:R-HSA-2871837|reactome:R-HSA-2894862|reactome:R-HSA-400253|reactome:R-HSA-5607761|reactome:R-HSA-5607764|reactome:R-HSA-5610780|reactome:R-HSA-5610783|reactome:R-HSA-5610785|reactome:R-HSA-5676590|reactome:R-HSA-5684264|reactome:R-HSA-68949|reactome:R-HSA-69231|reactome:R-HSA-8854050|reactome:R-HSA-8939902|reactome:R-HSA-8951664|reactome:R-HSA-9020702|reactome:R-HSA-917937|reactome:R-HSA-9604323|reactome:R-HSA-9708530|reactome:R-HSA-983168|refseq:XP_011514931.1|refseq:XP_011514932.1|refseq:XP_011514933.1|refseq:XP_011514934.1|ensembl:ENSG00000055130(gene)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|ensembl:ENST00000325222(transcript)|ensembl:ENST00000409469(transcript)|ensembl:ENST00000602748(transcript)|ensembl:ENST00000662716(transcript)|ensembl:ENST00000663044(transcript)|ensembl:ENST00000665936(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:1990452"(Parkin-FBXW7-Cul1 ubiquitin ligase complex)|interpro:IPR001373(Cullin, N-terminal region)|interpro:IPR016157(Cullin, conserved site)|interpro:IPR016158(Cullin homology)|interpro:IPR016159(Cullin repeat-like)|interpro:IPR019559|interpro:IPR036317|interpro:IPR036388|interpro:IPR036390|mint:Q13616|rcsb pdb:1LDJ|rcsb pdb:1LDK|rcsb pdb:1U6G|rcsb pdb:3RTR|rcsb pdb:3TDU|rcsb pdb:3TDZ|rcsb pdb:4F52|rcsb pdb:4P5O|rcsb pdb:5V89|rcsb pdb:6TTU|refseq:XP_005250117.1|dip:DIP-17013N|mint:MINT-7277512(identity)	refseq:NP_035409.1|refseq:NP_001298064.1|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021799"(cerebral cortex radially oriented cell migration)|go:"GO:0021942"(radial glia guided migration of Purkinje cell)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031466"(Cul5-RING ubiquitin ligase complex)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045116"(protein neddylation)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061663"(NEDD8 ligase activity)|go:"GO:0097602"(cullin family protein binding)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR024766|mint:Q9WTZ1|rcsb pdb:6V9I|reactome:R-MMU-8951664|reactome:R-MMU-9705462|reactome:R-MMU-983168|go:"GO:0008631"(intrinsic apoptotic signaling pathway in response to oxidative stress)|ensembl:ENSMUSG00000051234(gene)|ensembl:ENSMUST00000057500(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0008270"(zinc ion binding)|mint:MINT-7277513(identity)	-	-	-	figure legend:f2a|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7108(spofr-sf_9)|taxid:7108(Spodoptera frugiperda insect cells)	-	2009/10/05	2014/10/16	rogid:OAZP+ifWW3eEnQKb937ww9s1fMQ9606	rogid:Y/YRLbcyQ60cywUOcMKX+bQ1ayA10090	intact-crc:45A6952DCD6110B3|rigid:n/5alzu7t/jpUFrh+Yv1JGsCQ6U	false	ha tag:?-?(MINT-7277519)	myc tag:?-?(MINT-7277515)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q13617	uniprotkb:Q9WTZ1	intact:EBI-456179|uniprotkb:O00200|uniprotkb:Q5T2B6|uniprotkb:Q9UNF9|uniprotkb:D3DRY6|uniprotkb:B3KT95|uniprotkb:B7Z6K8|uniprotkb:G3V1S2|ensembl:ENSP00000363881|ensembl:ENSP00000363883|ensembl:ENSP00000501215|ensembl:ENSP00000363880	intact:EBI-2659373|uniprotkb:Q3UKF8|ensembl:ENSMUSP00000052856	psi-mi:cul2_human(display_long)|uniprotkb:CUL2(gene name)|psi-mi:CUL2(display_short)	psi-mi:rbx2_mouse(display_long)|uniprotkb:RING finger protein 7(gene name synonym)|uniprotkb:Sensitive to apoptosis gene protein(gene name synonym)|uniprotkb:Rbx2(gene name synonym)|uniprotkb:Sag(gene name synonym)|uniprotkb:Rnf7(gene name)|psi-mi:Rnf7(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Yasukawa et al. (2008)	mint:MINT-7277467|pubmed:19037258|imex:IM-13833|doi:10.1038/emboj.2008.249	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8508155|mint:MINT-7277523|imex:IM-13833-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001185706.1|refseq:NP_001185707.1|refseq:NP_001185708.1|refseq:NP_003582.2|refseq:XP_011518049.1|dip:DIP-31612N|ensembl:ENST00000374748(transcript)|ensembl:ENST00000374749(transcript)|ensembl:ENST00000374751(transcript)|ensembl:ENST00000673636(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0030891"(VCB complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031462"(Cul2-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|interpro:IPR001373(Cullin, N-terminal region)|interpro:IPR016157(Cullin, conserved site)|interpro:IPR016158(Cullin homology)|interpro:IPR016159(Cullin repeat-like)|interpro:IPR019559|interpro:IPR036317|interpro:IPR036388|interpro:IPR036390|mint:Q13617|rcsb pdb:4WQO|rcsb pdb:5N4W|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|rcsb pdb:6R7N|reactome:R-HSA-1234176|reactome:R-HSA-8951664|ensembl:ENSG00000108094(gene)|reactome:R-HSA-983168|reactome:R-HSA-9010553|mint:MINT-7277529(identity)	refseq:NP_035409.1|refseq:NP_001298064.1|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021799"(cerebral cortex radially oriented cell migration)|go:"GO:0021942"(radial glia guided migration of Purkinje cell)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031466"(Cul5-RING ubiquitin ligase complex)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045116"(protein neddylation)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061663"(NEDD8 ligase activity)|go:"GO:0097602"(cullin family protein binding)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR024766|mint:Q9WTZ1|rcsb pdb:6V9I|reactome:R-MMU-8951664|reactome:R-MMU-9705462|reactome:R-MMU-983168|go:"GO:0008631"(intrinsic apoptotic signaling pathway in response to oxidative stress)|ensembl:ENSMUSG00000051234(gene)|ensembl:ENSMUST00000057500(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0008270"(zinc ion binding)|mint:MINT-7277525(identity)	-	-	-	figure legend:f2a|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7108(spofr-sf_9)|taxid:7108(Spodoptera frugiperda insect cells)	-	2009/10/05	2014/10/16	rogid:ffttNV1NYH8UnmbHxf+ygcIG1wE9606	rogid:Y/YRLbcyQ60cywUOcMKX+bQ1ayA10090	intact-crc:417270BE4965FFF3|rigid:bpYGl8wIJvJpNV1JTLOIS2hzXC4	false	ha tag:?-?(MINT-7277530)	myc tag:?-?(MINT-7277526)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q13617	uniprotkb:P62878	intact:EBI-456179|uniprotkb:O00200|uniprotkb:Q5T2B6|uniprotkb:Q9UNF9|uniprotkb:D3DRY6|uniprotkb:B3KT95|uniprotkb:B7Z6K8|uniprotkb:G3V1S2|ensembl:ENSP00000363881|ensembl:ENSP00000363883|ensembl:ENSP00000501215|ensembl:ENSP00000363880	intact:EBI-2507414|ensembl:ENSMUSP00000023036|uniprotkb:Q8N6Z8|uniprotkb:Q9D1S2|uniprotkb:Q9WUK9|uniprotkb:Q9Y254	psi-mi:cul2_human(display_long)|uniprotkb:CUL2(gene name)|psi-mi:CUL2(display_short)	psi-mi:rbx1_mouse(display_long)|uniprotkb:RING finger protein 75(gene name synonym)|uniprotkb:RING-box protein 1(gene name synonym)|uniprotkb:Rbx1(gene name)|psi-mi:Rbx1(display_short)|uniprotkb:E3 ubiquitin-protein transferase RBX1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Yasukawa et al. (2008)	mint:MINT-7277467|pubmed:19037258|imex:IM-13833|doi:10.1038/emboj.2008.249	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8508155|mint:MINT-7277523|imex:IM-13833-4	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001185706.1|refseq:NP_001185707.1|refseq:NP_001185708.1|refseq:NP_003582.2|refseq:XP_011518049.1|dip:DIP-31612N|ensembl:ENST00000374748(transcript)|ensembl:ENST00000374749(transcript)|ensembl:ENST00000374751(transcript)|ensembl:ENST00000673636(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0030891"(VCB complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031462"(Cul2-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|interpro:IPR001373(Cullin, N-terminal region)|interpro:IPR016157(Cullin, conserved site)|interpro:IPR016158(Cullin homology)|interpro:IPR016159(Cullin repeat-like)|interpro:IPR019559|interpro:IPR036317|interpro:IPR036388|interpro:IPR036390|mint:Q13617|rcsb pdb:4WQO|rcsb pdb:5N4W|rcsb pdb:6R6H|rcsb pdb:6R7F|rcsb pdb:6R7H|rcsb pdb:6R7I|rcsb pdb:6R7N|reactome:R-HSA-1234176|reactome:R-HSA-8951664|ensembl:ENSG00000108094(gene)|reactome:R-HSA-983168|reactome:R-HSA-9010553|mint:MINT-7277529(identity)	go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045116"(protein neddylation)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061663"(NEDD8 ligase activity)|go:"GO:0034450"(ubiquitin-ubiquitin ligase activity)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0097602"(cullin family protein binding)|go:"GO:1902499"(positive regulation of protein autoubiquitination)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR024766|mint:P62878|rcsb pdb:4A0C|rcsb pdb:4A0K|rcsb pdb:4A0L|reactome:R-MMU-110314|reactome:R-MMU-1170546|reactome:R-MMU-1234176|reactome:R-MMU-195253|reactome:R-MMU-4641258|reactome:R-MMU-5610780|reactome:R-MMU-5610785|reactome:R-MMU-5632684|reactome:R-MMU-5658442|reactome:R-MMU-5696394|reactome:R-MMU-5696395|reactome:R-MMU-5696400|reactome:R-MMU-6781823|reactome:R-MMU-6782135|reactome:R-MMU-6782210|reactome:R-MMU-68949|reactome:R-MMU-8854050|reactome:R-MMU-8932339|reactome:R-MMU-8939902|reactome:R-MMU-8951664|reactome:R-MMU-9020702|reactome:R-MMU-9708530|reactome:R-MMU-983168|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005680"(anaphase-promoting complex)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0008190"(eukaryotic initiation factor 4E binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030891"(VCB complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031462"(Cul2-RING ubiquitin ligase complex)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|ensembl:ENSMUSG00000022400(gene)|go:"GO:0031464"(Cul4A-RING E3 ubiquitin ligase complex)|ensembl:ENSMUST00000023036(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0031465"(Cul4B-RING E3 ubiquitin ligase complex)|go:"GO:0031466"(Cul5-RING ubiquitin ligase complex)|go:"GO:0031467"(Cul7-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|refseq:NP_062686.1|mint:MINT-7277534(identity)	-	-	-	figure legend:f2a|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7108(spofr-sf_9)|taxid:7108(Spodoptera frugiperda insect cells)	-	2009/10/05	2014/10/16	rogid:ffttNV1NYH8UnmbHxf+ygcIG1wE9606	rogid:pSaSNRZo+QudTPXOLUlksOj3smM10090	intact-crc:417270BE4965FFF3|rigid:bpYGl8wIJvJpNV1JTLOIS2hzXC4	false	ha tag:?-?(MINT-7277530)	myc tag:?-?(MINT-7277537)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q13618	uniprotkb:Q9WTZ1	intact:EBI-456129|uniprotkb:O75415|uniprotkb:Q569L3|uniprotkb:Q9UBI8|uniprotkb:B8ZZC3|uniprotkb:Q9UET7|uniprotkb:A8K536|ensembl:ENSP00000264414	intact:EBI-2659373|uniprotkb:Q3UKF8|ensembl:ENSMUSP00000052856	psi-mi:cul3_human(display_long)|uniprotkb:CUL3(gene name)|psi-mi:CUL3(display_short)|uniprotkb:KIAA0617(gene name synonym)	psi-mi:rbx2_mouse(display_long)|uniprotkb:RING finger protein 7(gene name synonym)|uniprotkb:Sensitive to apoptosis gene protein(gene name synonym)|uniprotkb:Rbx2(gene name synonym)|uniprotkb:Sag(gene name synonym)|uniprotkb:Rnf7(gene name)|psi-mi:Rnf7(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Yasukawa et al. (2008)	mint:MINT-7277467|pubmed:19037258|imex:IM-13833|doi:10.1038/emboj.2008.249	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8508179|mint:MINT-7277541|imex:IM-13833-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003581.1|refseq:NP_001244126.1|refseq:NP_001244127.1|dip:DIP-31611N|ensembl:ENSG00000036257(gene)|ensembl:ENST00000264414(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000922"(spindle pole)|go:"GO:0001831"(trophectodermal cellular morphogenesis)|go:"GO:0005112"(Notch binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005827"(polar microtubule)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007369"(gastrulation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016477"(cell migration)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0017145"(stem cell division)|go:"GO:0030030"(cell projection organization)|go:"GO:0030332"(cyclin binding)|go:"GO:0031145"(anaphase-promoting complex-dependent catabolic process)|go:"GO:0031208"(POZ domain binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0036126"(sperm flagellum)|go:"GO:0040016"(embryonic cleavage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044346"(fibroblast apoptotic process)|go:"GO:0045842"(positive regulation of mitotic metaphase/anaphase transition)|go:"GO:0048208"(COPII vesicle coating)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0071630"(nuclear protein quality control by the ubiquitin-proteasome system)|go:"GO:0072576"(liver morphogenesis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:1901992"(positive regulation of mitotic cell cycle phase transition)|interpro:IPR001373(Cullin, N-terminal region)|interpro:IPR016157(Cullin, conserved site)|interpro:IPR016158(Cullin homology)|interpro:IPR016159(Cullin repeat-like)|interpro:IPR019559|interpro:IPR036317|interpro:IPR036388|interpro:IPR036390|mint:Q13618|rcsb pdb:2MYL|rcsb pdb:2MYM|rcsb pdb:4AP2|rcsb pdb:4APF|rcsb pdb:4EOZ|rcsb pdb:4HXI|rcsb pdb:5NLB|rcsb pdb:6I2M|reactome:R-HSA-4641258|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-8932339|reactome:R-HSA-8951664|reactome:R-HSA-9013418|reactome:R-HSA-9013422|reactome:R-HSA-9706019|reactome:R-HSA-983168|mint:MINT-7277543(identity)	refseq:NP_035409.1|refseq:NP_001298064.1|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021799"(cerebral cortex radially oriented cell migration)|go:"GO:0021942"(radial glia guided migration of Purkinje cell)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031466"(Cul5-RING ubiquitin ligase complex)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045116"(protein neddylation)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061663"(NEDD8 ligase activity)|go:"GO:0097602"(cullin family protein binding)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR024766|mint:Q9WTZ1|rcsb pdb:6V9I|reactome:R-MMU-8951664|reactome:R-MMU-9705462|reactome:R-MMU-983168|go:"GO:0008631"(intrinsic apoptotic signaling pathway in response to oxidative stress)|ensembl:ENSMUSG00000051234(gene)|ensembl:ENSMUST00000057500(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0008270"(zinc ion binding)|mint:MINT-7277551(identity)	-	-	-	figure legend:f2a|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7108(spofr-sf_9)|taxid:7108(Spodoptera frugiperda insect cells)	-	2009/10/05	2014/10/16	rogid:xI/8pHB9nckOW629STOqKba4KzQ9606	rogid:Y/YRLbcyQ60cywUOcMKX+bQ1ayA10090	intact-crc:D4AB135E3B14F447|rigid:WJVntAusQj9Hc6/Os7vtmKUnoVs	false	ha tag:?-?(MINT-7277544)	myc tag:?-?(MINT-7277552)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q13618	uniprotkb:P62878	intact:EBI-456129|uniprotkb:O75415|uniprotkb:Q569L3|uniprotkb:Q9UBI8|uniprotkb:B8ZZC3|uniprotkb:Q9UET7|uniprotkb:A8K536|ensembl:ENSP00000264414	intact:EBI-2507414|ensembl:ENSMUSP00000023036|uniprotkb:Q8N6Z8|uniprotkb:Q9D1S2|uniprotkb:Q9WUK9|uniprotkb:Q9Y254	psi-mi:cul3_human(display_long)|uniprotkb:CUL3(gene name)|psi-mi:CUL3(display_short)|uniprotkb:KIAA0617(gene name synonym)	psi-mi:rbx1_mouse(display_long)|uniprotkb:RING finger protein 75(gene name synonym)|uniprotkb:RING-box protein 1(gene name synonym)|uniprotkb:Rbx1(gene name)|psi-mi:Rbx1(display_short)|uniprotkb:E3 ubiquitin-protein transferase RBX1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Yasukawa et al. (2008)	mint:MINT-7277467|pubmed:19037258|imex:IM-13833|doi:10.1038/emboj.2008.249	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8508179|mint:MINT-7277541|imex:IM-13833-5	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003581.1|refseq:NP_001244126.1|refseq:NP_001244127.1|dip:DIP-31611N|ensembl:ENSG00000036257(gene)|ensembl:ENST00000264414(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000922"(spindle pole)|go:"GO:0001831"(trophectodermal cellular morphogenesis)|go:"GO:0005112"(Notch binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005827"(polar microtubule)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007369"(gastrulation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016477"(cell migration)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0017145"(stem cell division)|go:"GO:0030030"(cell projection organization)|go:"GO:0030332"(cyclin binding)|go:"GO:0031145"(anaphase-promoting complex-dependent catabolic process)|go:"GO:0031208"(POZ domain binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0036126"(sperm flagellum)|go:"GO:0040016"(embryonic cleavage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044346"(fibroblast apoptotic process)|go:"GO:0045842"(positive regulation of mitotic metaphase/anaphase transition)|go:"GO:0048208"(COPII vesicle coating)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0071630"(nuclear protein quality control by the ubiquitin-proteasome system)|go:"GO:0072576"(liver morphogenesis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|go:"GO:1901992"(positive regulation of mitotic cell cycle phase transition)|interpro:IPR001373(Cullin, N-terminal region)|interpro:IPR016157(Cullin, conserved site)|interpro:IPR016158(Cullin homology)|interpro:IPR016159(Cullin repeat-like)|interpro:IPR019559|interpro:IPR036317|interpro:IPR036388|interpro:IPR036390|mint:Q13618|rcsb pdb:2MYL|rcsb pdb:2MYM|rcsb pdb:4AP2|rcsb pdb:4APF|rcsb pdb:4EOZ|rcsb pdb:4HXI|rcsb pdb:5NLB|rcsb pdb:6I2M|reactome:R-HSA-4641258|reactome:R-HSA-5632684|reactome:R-HSA-5658442|reactome:R-HSA-8932339|reactome:R-HSA-8951664|reactome:R-HSA-9013418|reactome:R-HSA-9013422|reactome:R-HSA-9706019|reactome:R-HSA-983168|mint:MINT-7277543(identity)	go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045116"(protein neddylation)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061663"(NEDD8 ligase activity)|go:"GO:0034450"(ubiquitin-ubiquitin ligase activity)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0097602"(cullin family protein binding)|go:"GO:1902499"(positive regulation of protein autoubiquitination)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR024766|mint:P62878|rcsb pdb:4A0C|rcsb pdb:4A0K|rcsb pdb:4A0L|reactome:R-MMU-110314|reactome:R-MMU-1170546|reactome:R-MMU-1234176|reactome:R-MMU-195253|reactome:R-MMU-4641258|reactome:R-MMU-5610780|reactome:R-MMU-5610785|reactome:R-MMU-5632684|reactome:R-MMU-5658442|reactome:R-MMU-5696394|reactome:R-MMU-5696395|reactome:R-MMU-5696400|reactome:R-MMU-6781823|reactome:R-MMU-6782135|reactome:R-MMU-6782210|reactome:R-MMU-68949|reactome:R-MMU-8854050|reactome:R-MMU-8932339|reactome:R-MMU-8939902|reactome:R-MMU-8951664|reactome:R-MMU-9020702|reactome:R-MMU-9708530|reactome:R-MMU-983168|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005680"(anaphase-promoting complex)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0008190"(eukaryotic initiation factor 4E binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030891"(VCB complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031462"(Cul2-RING ubiquitin ligase complex)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|ensembl:ENSMUSG00000022400(gene)|go:"GO:0031464"(Cul4A-RING E3 ubiquitin ligase complex)|ensembl:ENSMUST00000023036(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0031465"(Cul4B-RING E3 ubiquitin ligase complex)|go:"GO:0031466"(Cul5-RING ubiquitin ligase complex)|go:"GO:0031467"(Cul7-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|refseq:NP_062686.1|mint:MINT-7277547(identity)	-	-	-	figure legend:f2a|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7108(spofr-sf_9)|taxid:7108(Spodoptera frugiperda insect cells)	-	2009/10/05	2014/10/16	rogid:xI/8pHB9nckOW629STOqKba4KzQ9606	rogid:pSaSNRZo+QudTPXOLUlksOj3smM10090	intact-crc:D4AB135E3B14F447|rigid:WJVntAusQj9Hc6/Os7vtmKUnoVs	false	ha tag:?-?(MINT-7277544)	myc tag:?-?(MINT-7277548)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q3TCH7	uniprotkb:P62878	intact:EBI-8320699|uniprotkb:Q3THM3|uniprotkb:Q91Z44|intact:MINT-4122171|ensembl:ENSMUSP00000016680	intact:EBI-2507414|ensembl:ENSMUSP00000023036|uniprotkb:Q8N6Z8|uniprotkb:Q9D1S2|uniprotkb:Q9WUK9|uniprotkb:Q9Y254	psi-mi:cul4a_mouse(display_long)|uniprotkb:Cul4a(gene name)|psi-mi:Cul4a(display_short)	psi-mi:rbx1_mouse(display_long)|uniprotkb:RING finger protein 75(gene name synonym)|uniprotkb:RING-box protein 1(gene name synonym)|uniprotkb:Rbx1(gene name)|psi-mi:Rbx1(display_short)|uniprotkb:E3 ubiquitin-protein transferase RBX1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Yasukawa et al. (2008)	mint:MINT-7277467|pubmed:19037258|imex:IM-13833|doi:10.1038/emboj.2008.249	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8508203|mint:MINT-7277557|imex:IM-13833-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_666319.2|ensembl:ENSMUSG00000031446(gene)|ensembl:ENSMUST00000016680(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0006281"(DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030853"(negative regulation of granulocyte differentiation)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031464"(Cul4A-RING E3 ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042254"(ribosome biogenesis)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0048511"(rhythmic process)|go:"GO:0051246"(regulation of protein metabolic process)|go:"GO:0080008"(Cul4-RING E3 ubiquitin ligase complex)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000001"(regulation of DNA damage checkpoint)|go:"GO:2000819"(regulation of nucleotide-excision repair)|interpro:IPR001373(Cullin, N-terminal region)|interpro:IPR016157(Cullin, conserved site)|interpro:IPR016158(Cullin homology)|interpro:IPR016159(Cullin repeat-like)|interpro:IPR019559|interpro:IPR036317|interpro:IPR036388|interpro:IPR036390|mint:Q3TCH7|reactome:R-MMU-110314|reactome:R-MMU-5696394|reactome:R-MMU-5696395|reactome:R-MMU-5696400|reactome:R-MMU-6781823|reactome:R-MMU-6782135|reactome:R-MMU-6782210|reactome:R-MMU-8951664|mint:MINT-7277559(identity)	go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045116"(protein neddylation)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061663"(NEDD8 ligase activity)|go:"GO:0034450"(ubiquitin-ubiquitin ligase activity)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0097602"(cullin family protein binding)|go:"GO:1902499"(positive regulation of protein autoubiquitination)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR024766|mint:P62878|rcsb pdb:4A0C|rcsb pdb:4A0K|rcsb pdb:4A0L|reactome:R-MMU-110314|reactome:R-MMU-1170546|reactome:R-MMU-1234176|reactome:R-MMU-195253|reactome:R-MMU-4641258|reactome:R-MMU-5610780|reactome:R-MMU-5610785|reactome:R-MMU-5632684|reactome:R-MMU-5658442|reactome:R-MMU-5696394|reactome:R-MMU-5696395|reactome:R-MMU-5696400|reactome:R-MMU-6781823|reactome:R-MMU-6782135|reactome:R-MMU-6782210|reactome:R-MMU-68949|reactome:R-MMU-8854050|reactome:R-MMU-8932339|reactome:R-MMU-8939902|reactome:R-MMU-8951664|reactome:R-MMU-9020702|reactome:R-MMU-9708530|reactome:R-MMU-983168|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005680"(anaphase-promoting complex)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0008190"(eukaryotic initiation factor 4E binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030891"(VCB complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031462"(Cul2-RING ubiquitin ligase complex)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|ensembl:ENSMUSG00000022400(gene)|go:"GO:0031464"(Cul4A-RING E3 ubiquitin ligase complex)|ensembl:ENSMUST00000023036(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0031465"(Cul4B-RING E3 ubiquitin ligase complex)|go:"GO:0031466"(Cul5-RING ubiquitin ligase complex)|go:"GO:0031467"(Cul7-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|refseq:NP_062686.1|mint:MINT-7277567(identity)	-	function:"Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. DCX(DET1-COP1) directs ubiquitination of JUN. DCX(DDB2) directs ubiquitination of XPC. In association with RBX1, DDB1 and DDB2 is required for histone H3 and histone H4 ubiquitination in response to ultraviolet and may be important for subsequent DNA repair. DCX(DTL) plays a role in PCNA-dependent polyubiquitination of CDT1 and MDM2-dependent ubiquitiantion of TP53 in response to radiation-induced DNA damage and during DNA replication. In association with DDB1 and SKP2 probably is involved in ubiquitination of CDKN1B/p27kip. Is involved in ubiquitination of HOXA9"|comment:mint	-	figure legend:f2a|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7108(spofr-sf_9)|taxid:7108(Spodoptera frugiperda insect cells)	-	2009/10/05	2014/10/16	rogid:nGMM2MrmponVO+86aankGqgUIVY10090	rogid:pSaSNRZo+QudTPXOLUlksOj3smM10090	intact-crc:0EE17F919179CF67|rigid:zas5b0uHCzQTfe5dPUXiO+L32rg	false	ha tag:?-?(MINT-7277560)	myc tag:?-?(MINT-7277568)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q3TCH7	uniprotkb:Q9WTZ1	intact:EBI-8320699|uniprotkb:Q3THM3|uniprotkb:Q91Z44|intact:MINT-4122171|ensembl:ENSMUSP00000016680	intact:EBI-2659373|uniprotkb:Q3UKF8|ensembl:ENSMUSP00000052856	psi-mi:cul4a_mouse(display_long)|uniprotkb:Cul4a(gene name)|psi-mi:Cul4a(display_short)	psi-mi:rbx2_mouse(display_long)|uniprotkb:RING finger protein 7(gene name synonym)|uniprotkb:Sensitive to apoptosis gene protein(gene name synonym)|uniprotkb:Rbx2(gene name synonym)|uniprotkb:Sag(gene name synonym)|uniprotkb:Rnf7(gene name)|psi-mi:Rnf7(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Yasukawa et al. (2008)	mint:MINT-7277467|pubmed:19037258|imex:IM-13833|doi:10.1038/emboj.2008.249	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8508203|mint:MINT-7277557|imex:IM-13833-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_666319.2|ensembl:ENSMUSG00000031446(gene)|ensembl:ENSMUST00000016680(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0006281"(DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030853"(negative regulation of granulocyte differentiation)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031464"(Cul4A-RING E3 ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042254"(ribosome biogenesis)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0048511"(rhythmic process)|go:"GO:0051246"(regulation of protein metabolic process)|go:"GO:0080008"(Cul4-RING E3 ubiquitin ligase complex)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000001"(regulation of DNA damage checkpoint)|go:"GO:2000819"(regulation of nucleotide-excision repair)|interpro:IPR001373(Cullin, N-terminal region)|interpro:IPR016157(Cullin, conserved site)|interpro:IPR016158(Cullin homology)|interpro:IPR016159(Cullin repeat-like)|interpro:IPR019559|interpro:IPR036317|interpro:IPR036388|interpro:IPR036390|mint:Q3TCH7|reactome:R-MMU-110314|reactome:R-MMU-5696394|reactome:R-MMU-5696395|reactome:R-MMU-5696400|reactome:R-MMU-6781823|reactome:R-MMU-6782135|reactome:R-MMU-6782210|reactome:R-MMU-8951664|mint:MINT-7277559(identity)	refseq:NP_035409.1|refseq:NP_001298064.1|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021799"(cerebral cortex radially oriented cell migration)|go:"GO:0021942"(radial glia guided migration of Purkinje cell)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031466"(Cul5-RING ubiquitin ligase complex)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045116"(protein neddylation)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061663"(NEDD8 ligase activity)|go:"GO:0097602"(cullin family protein binding)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR024766|mint:Q9WTZ1|rcsb pdb:6V9I|reactome:R-MMU-8951664|reactome:R-MMU-9705462|reactome:R-MMU-983168|go:"GO:0008631"(intrinsic apoptotic signaling pathway in response to oxidative stress)|ensembl:ENSMUSG00000051234(gene)|ensembl:ENSMUST00000057500(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0008270"(zinc ion binding)|mint:MINT-7277563(identity)	-	function:"Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. DCX(DET1-COP1) directs ubiquitination of JUN. DCX(DDB2) directs ubiquitination of XPC. In association with RBX1, DDB1 and DDB2 is required for histone H3 and histone H4 ubiquitination in response to ultraviolet and may be important for subsequent DNA repair. DCX(DTL) plays a role in PCNA-dependent polyubiquitination of CDT1 and MDM2-dependent ubiquitiantion of TP53 in response to radiation-induced DNA damage and during DNA replication. In association with DDB1 and SKP2 probably is involved in ubiquitination of CDKN1B/p27kip. Is involved in ubiquitination of HOXA9"|comment:mint	-	figure legend:f2a|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7108(spofr-sf_9)|taxid:7108(Spodoptera frugiperda insect cells)	-	2009/10/05	2014/10/16	rogid:nGMM2MrmponVO+86aankGqgUIVY10090	rogid:Y/YRLbcyQ60cywUOcMKX+bQ1ayA10090	intact-crc:0EE17F919179CF67|rigid:zas5b0uHCzQTfe5dPUXiO+L32rg	false	ha tag:?-?(MINT-7277560)	myc tag:?-?(MINT-7277564)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q3TCH7	uniprotkb:P83941	intact:EBI-8320699|uniprotkb:Q3THM3|uniprotkb:Q91Z44|intact:MINT-4122171|ensembl:ENSMUSP00000016680	intact:EBI-398626|uniprotkb:Q63182|ensembl:ENSRNOP00000067410|ensembl:ENSRNOP00000069739|ensembl:ENSRNOP00000071456	psi-mi:cul4a_mouse(display_long)|uniprotkb:Cul4a(gene name)|psi-mi:Cul4a(display_short)	psi-mi:eloc_rat(display_long)|uniprotkb:Eloc(gene name)|psi-mi:Eloc(display_short)|uniprotkb:Elongin 15 kDa subunit(gene name synonym)|uniprotkb:RNA polymerase II transcription factor SIII subunit C(gene name synonym)|uniprotkb:SIII p15(gene name synonym)|uniprotkb:Stromal membrane-associated protein SMAP1B homolog(gene name synonym)|uniprotkb:Tceb1(gene name synonym)|uniprotkb:Transcription elongation factor B polypeptide 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Yasukawa et al. (2008)	mint:MINT-7277467|pubmed:19037258|imex:IM-13833|doi:10.1038/emboj.2008.249	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8508203|mint:MINT-7277557|imex:IM-13833-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_666319.2|ensembl:ENSMUSG00000031446(gene)|ensembl:ENSMUST00000016680(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0006281"(DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030853"(negative regulation of granulocyte differentiation)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031464"(Cul4A-RING E3 ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042254"(ribosome biogenesis)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0048511"(rhythmic process)|go:"GO:0051246"(regulation of protein metabolic process)|go:"GO:0080008"(Cul4-RING E3 ubiquitin ligase complex)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000001"(regulation of DNA damage checkpoint)|go:"GO:2000819"(regulation of nucleotide-excision repair)|interpro:IPR001373(Cullin, N-terminal region)|interpro:IPR016157(Cullin, conserved site)|interpro:IPR016158(Cullin homology)|interpro:IPR016159(Cullin repeat-like)|interpro:IPR019559|interpro:IPR036317|interpro:IPR036388|interpro:IPR036390|mint:Q3TCH7|reactome:R-MMU-110314|reactome:R-MMU-5696394|reactome:R-MMU-5696395|reactome:R-MMU-5696400|reactome:R-MMU-6781823|reactome:R-MMU-6782135|reactome:R-MMU-6782210|reactome:R-MMU-8951664|mint:MINT-7277559(identity)	rgd:620658|refseq:NP_072115.1|refseq:XP_006237786.1|refseq:NP_001257490.1|refseq:NP_001257491.1|refseq:NP_001257492.1|reactome:R-RNO-674695|reactome:R-RNO-6796648|reactome:R-RNO-75955|reactome:R-RNO-8951664|reactome:R-RNO-9705462|reactome:R-RNO-983168|reactome:R-RNO-1234176|ensembl:ENSRNOG00000031730(gene)|ensembl:ENSRNOT00000050236(transcript)|ensembl:ENSRNOT00000082813(transcript)|ensembl:ENSRNOT00000090313(transcript)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030891"(VCB complex)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0070449"(elongin complex)|interpro:IPR001232(SKP1 component)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR016073(SKP1 component, POZ)|interpro:IPR039948|mint:P83941|reactome:R-RNO-112382|mint:MINT-7277574(identity)	-	function:"Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. DCX(DET1-COP1) directs ubiquitination of JUN. DCX(DDB2) directs ubiquitination of XPC. In association with RBX1, DDB1 and DDB2 is required for histone H3 and histone H4 ubiquitination in response to ultraviolet and may be important for subsequent DNA repair. DCX(DTL) plays a role in PCNA-dependent polyubiquitination of CDT1 and MDM2-dependent ubiquitiantion of TP53 in response to radiation-induced DNA damage and during DNA replication. In association with DDB1 and SKP2 probably is involved in ubiquitination of CDKN1B/p27kip. Is involved in ubiquitination of HOXA9"|comment:mint	-	figure legend:f2a|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7108(spofr-sf_9)|taxid:7108(Spodoptera frugiperda insect cells)	-	2009/10/05	2014/10/16	rogid:nGMM2MrmponVO+86aankGqgUIVY10090	rogid:Ngvkh3YoddZoutF3Vgwdi2b6xz410116	intact-crc:0EE17F919179CF67|rigid:zas5b0uHCzQTfe5dPUXiO+L32rg	false	ha tag:?-?(MINT-7277560)	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q3TCH7	uniprotkb:P62870	intact:EBI-8320699|uniprotkb:Q3THM3|uniprotkb:Q91Z44|intact:MINT-4122171|ensembl:ENSMUSP00000016680	intact:EBI-918620|uniprotkb:Q63529|uniprotkb:Q80W20|ensembl:ENSRNOP00000072621	psi-mi:cul4a_mouse(display_long)|uniprotkb:Cul4a(gene name)|psi-mi:Cul4a(display_short)	psi-mi:elob_rat(display_long)|uniprotkb:Elob(gene name)|psi-mi:Elob(display_short)|uniprotkb:Elongin 18 kDa subunit(gene name synonym)|uniprotkb:RNA polymerase II transcription factor SIII subunit B(gene name synonym)|uniprotkb:SIII p18(gene name synonym)|uniprotkb:Tceb2(gene name synonym)|uniprotkb:Transcription elongation factor B polypeptide 2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Yasukawa et al. (2008)	mint:MINT-7277467|pubmed:19037258|imex:IM-13833|doi:10.1038/emboj.2008.249	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8508203|mint:MINT-7277557|imex:IM-13833-6	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_666319.2|ensembl:ENSMUSG00000031446(gene)|ensembl:ENSMUST00000016680(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0006281"(DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030853"(negative regulation of granulocyte differentiation)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031464"(Cul4A-RING E3 ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042254"(ribosome biogenesis)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0048511"(rhythmic process)|go:"GO:0051246"(regulation of protein metabolic process)|go:"GO:0080008"(Cul4-RING E3 ubiquitin ligase complex)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000001"(regulation of DNA damage checkpoint)|go:"GO:2000819"(regulation of nucleotide-excision repair)|interpro:IPR001373(Cullin, N-terminal region)|interpro:IPR016157(Cullin, conserved site)|interpro:IPR016158(Cullin homology)|interpro:IPR016159(Cullin repeat-like)|interpro:IPR019559|interpro:IPR036317|interpro:IPR036388|interpro:IPR036390|mint:Q3TCH7|reactome:R-MMU-110314|reactome:R-MMU-5696394|reactome:R-MMU-5696395|reactome:R-MMU-5696400|reactome:R-MMU-6781823|reactome:R-MMU-6782135|reactome:R-MMU-6782210|reactome:R-MMU-8951664|mint:MINT-7277559(identity)	rgd:621200|refseq:NP_112391.1|ensembl:ENSRNOG00000004814(gene)|ensembl:ENSRNOT00000087768(transcript)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030891"(VCB complex)|go:"GO:0031462"(Cul2-RING ubiquitin ligase complex)|go:"GO:0031466"(Cul5-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070449"(elongin complex)|interpro:IPR000626(Ubiquitin)|interpro:IPR029071|interpro:IPR039049|mint:P62870|reactome:R-RNO-112382|reactome:R-RNO-1234176|reactome:R-RNO-674695|reactome:R-RNO-6796648|reactome:R-RNO-75955|reactome:R-RNO-8951664|reactome:R-RNO-9705462|reactome:R-RNO-983168|mint:MINT-7277573(identity)	-	function:"Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. DCX(DET1-COP1) directs ubiquitination of JUN. DCX(DDB2) directs ubiquitination of XPC. In association with RBX1, DDB1 and DDB2 is required for histone H3 and histone H4 ubiquitination in response to ultraviolet and may be important for subsequent DNA repair. DCX(DTL) plays a role in PCNA-dependent polyubiquitination of CDT1 and MDM2-dependent ubiquitiantion of TP53 in response to radiation-induced DNA damage and during DNA replication. In association with DDB1 and SKP2 probably is involved in ubiquitination of CDKN1B/p27kip. Is involved in ubiquitination of HOXA9"|comment:mint	-	figure legend:f2a|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7108(spofr-sf_9)|taxid:7108(Spodoptera frugiperda insect cells)	-	2009/10/05	2014/10/16	rogid:nGMM2MrmponVO+86aankGqgUIVY10090	rogid:7W4I9AcvS1GK89dMmBOImMYNgLY10116	intact-crc:0EE17F919179CF67|rigid:zas5b0uHCzQTfe5dPUXiO+L32rg	false	ha tag:?-?(MINT-7277560)	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q63187	uniprotkb:P62870	intact:EBI-8508308|intact:MINT-4598437	intact:EBI-918620|uniprotkb:Q63529|uniprotkb:Q80W20|ensembl:ENSRNOP00000072621	psi-mi:eloa1_rat(display_long)|uniprotkb:Eloa(gene name)|psi-mi:Eloa(display_short)|uniprotkb:Elongin 110 kDa subunit(gene name synonym)|uniprotkb:RNA polymerase II transcription factor SIII subunit A1(gene name synonym)|uniprotkb:SIII p110(gene name synonym)|uniprotkb:Tceb3(gene name synonym)|uniprotkb:Transcription elongation factor B polypeptide 3(gene name synonym)	psi-mi:elob_rat(display_long)|uniprotkb:Elob(gene name)|psi-mi:Elob(display_short)|uniprotkb:Elongin 18 kDa subunit(gene name synonym)|uniprotkb:RNA polymerase II transcription factor SIII subunit B(gene name synonym)|uniprotkb:SIII p18(gene name synonym)|uniprotkb:Tceb2(gene name synonym)|uniprotkb:Transcription elongation factor B polypeptide 2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Yasukawa et al. (2008)	mint:MINT-7277467|pubmed:19037258|imex:IM-13833|doi:10.1038/emboj.2008.249	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8508366|mint:MINT-7277630|imex:IM-13833-8	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:3827|interpro:IPR017923|mint:Q63187|interpro:IPR035441|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0008023"(transcription elongation factor complex)|go:"GO:0070449"(elongin complex)|go:"GO:0090734"(site of DNA damage)|reactome:R-RNO-112382|reactome:R-RNO-674695|reactome:R-RNO-6796648|reactome:R-RNO-75955|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR003617(Transcription elongation factor, TFIIS/CRSP70, N-terminal, sub-type)|interpro:IPR010684(RNA polymerase II transcription factor SIII, subunit A)|mint:MINT-7277632(identity)	rgd:621200|refseq:NP_112391.1|ensembl:ENSRNOG00000004814(gene)|ensembl:ENSRNOT00000087768(transcript)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030891"(VCB complex)|go:"GO:0031462"(Cul2-RING ubiquitin ligase complex)|go:"GO:0031466"(Cul5-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070449"(elongin complex)|interpro:IPR000626(Ubiquitin)|interpro:IPR029071|interpro:IPR039049|mint:P62870|reactome:R-RNO-112382|reactome:R-RNO-1234176|reactome:R-RNO-674695|reactome:R-RNO-6796648|reactome:R-RNO-75955|reactome:R-RNO-8951664|reactome:R-RNO-9705462|reactome:R-RNO-983168|mint:MINT-7277648(identity)	-	comment:mint|function:"SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex)"	-	figure legend:f2a|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7108(spofr-sf_9)|taxid:7108(Spodoptera frugiperda insect cells)	-	2009/10/05	2014/10/16	rogid:5kaSyBAZ8eag2OUs24Sci+iN5+Y10116	rogid:7W4I9AcvS1GK89dMmBOImMYNgLY10116	intact-crc:496874D09E56C00C|rigid:wyaymlOPHBQwXcluaX9370cCi18	false	flag tag:?-?(MINT-7277633)	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q63187	uniprotkb:Q9WTZ1	intact:EBI-8508308|intact:MINT-4598437	intact:EBI-2659373|uniprotkb:Q3UKF8|ensembl:ENSMUSP00000052856	psi-mi:eloa1_rat(display_long)|uniprotkb:Eloa(gene name)|psi-mi:Eloa(display_short)|uniprotkb:Elongin 110 kDa subunit(gene name synonym)|uniprotkb:RNA polymerase II transcription factor SIII subunit A1(gene name synonym)|uniprotkb:SIII p110(gene name synonym)|uniprotkb:Tceb3(gene name synonym)|uniprotkb:Transcription elongation factor B polypeptide 3(gene name synonym)	psi-mi:rbx2_mouse(display_long)|uniprotkb:RING finger protein 7(gene name synonym)|uniprotkb:Sensitive to apoptosis gene protein(gene name synonym)|uniprotkb:Rbx2(gene name synonym)|uniprotkb:Sag(gene name synonym)|uniprotkb:Rnf7(gene name)|psi-mi:Rnf7(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Yasukawa et al. (2008)	mint:MINT-7277467|pubmed:19037258|imex:IM-13833|doi:10.1038/emboj.2008.249	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8508366|mint:MINT-7277630|imex:IM-13833-8	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:3827|interpro:IPR017923|mint:Q63187|interpro:IPR035441|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0008023"(transcription elongation factor complex)|go:"GO:0070449"(elongin complex)|go:"GO:0090734"(site of DNA damage)|reactome:R-RNO-112382|reactome:R-RNO-674695|reactome:R-RNO-6796648|reactome:R-RNO-75955|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR003617(Transcription elongation factor, TFIIS/CRSP70, N-terminal, sub-type)|interpro:IPR010684(RNA polymerase II transcription factor SIII, subunit A)|mint:MINT-7277632(identity)	refseq:NP_035409.1|refseq:NP_001298064.1|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021799"(cerebral cortex radially oriented cell migration)|go:"GO:0021942"(radial glia guided migration of Purkinje cell)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031466"(Cul5-RING ubiquitin ligase complex)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045116"(protein neddylation)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061663"(NEDD8 ligase activity)|go:"GO:0097602"(cullin family protein binding)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR024766|mint:Q9WTZ1|rcsb pdb:6V9I|reactome:R-MMU-8951664|reactome:R-MMU-9705462|reactome:R-MMU-983168|go:"GO:0008631"(intrinsic apoptotic signaling pathway in response to oxidative stress)|ensembl:ENSMUSG00000051234(gene)|ensembl:ENSMUST00000057500(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0008270"(zinc ion binding)|mint:MINT-7277640(identity)	-	comment:mint|function:"SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex)"	-	figure legend:f2a|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7108(spofr-sf_9)|taxid:7108(Spodoptera frugiperda insect cells)	-	2009/10/05	2014/10/16	rogid:5kaSyBAZ8eag2OUs24Sci+iN5+Y10116	rogid:Y/YRLbcyQ60cywUOcMKX+bQ1ayA10090	intact-crc:496874D09E56C00C|rigid:wyaymlOPHBQwXcluaX9370cCi18	false	flag tag:?-?(MINT-7277633)	myc tag:?-?(MINT-7277641)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q63187	uniprotkb:P83941	intact:EBI-8508308|intact:MINT-4598437	intact:EBI-398626|uniprotkb:Q63182|ensembl:ENSRNOP00000067410|ensembl:ENSRNOP00000069739|ensembl:ENSRNOP00000071456	psi-mi:eloa1_rat(display_long)|uniprotkb:Eloa(gene name)|psi-mi:Eloa(display_short)|uniprotkb:Elongin 110 kDa subunit(gene name synonym)|uniprotkb:RNA polymerase II transcription factor SIII subunit A1(gene name synonym)|uniprotkb:SIII p110(gene name synonym)|uniprotkb:Tceb3(gene name synonym)|uniprotkb:Transcription elongation factor B polypeptide 3(gene name synonym)	psi-mi:eloc_rat(display_long)|uniprotkb:Eloc(gene name)|psi-mi:Eloc(display_short)|uniprotkb:Elongin 15 kDa subunit(gene name synonym)|uniprotkb:RNA polymerase II transcription factor SIII subunit C(gene name synonym)|uniprotkb:SIII p15(gene name synonym)|uniprotkb:Stromal membrane-associated protein SMAP1B homolog(gene name synonym)|uniprotkb:Tceb1(gene name synonym)|uniprotkb:Transcription elongation factor B polypeptide 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Yasukawa et al. (2008)	mint:MINT-7277467|pubmed:19037258|imex:IM-13833|doi:10.1038/emboj.2008.249	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8508366|mint:MINT-7277630|imex:IM-13833-8	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:3827|interpro:IPR017923|mint:Q63187|interpro:IPR035441|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0008023"(transcription elongation factor complex)|go:"GO:0070449"(elongin complex)|go:"GO:0090734"(site of DNA damage)|reactome:R-RNO-112382|reactome:R-RNO-674695|reactome:R-RNO-6796648|reactome:R-RNO-75955|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR003617(Transcription elongation factor, TFIIS/CRSP70, N-terminal, sub-type)|interpro:IPR010684(RNA polymerase II transcription factor SIII, subunit A)|mint:MINT-7277632(identity)	rgd:620658|refseq:NP_072115.1|refseq:XP_006237786.1|refseq:NP_001257490.1|refseq:NP_001257491.1|refseq:NP_001257492.1|reactome:R-RNO-674695|reactome:R-RNO-6796648|reactome:R-RNO-75955|reactome:R-RNO-8951664|reactome:R-RNO-9705462|reactome:R-RNO-983168|reactome:R-RNO-1234176|ensembl:ENSRNOG00000031730(gene)|ensembl:ENSRNOT00000050236(transcript)|ensembl:ENSRNOT00000082813(transcript)|ensembl:ENSRNOT00000090313(transcript)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030891"(VCB complex)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0070449"(elongin complex)|interpro:IPR001232(SKP1 component)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR016073(SKP1 component, POZ)|interpro:IPR039948|mint:P83941|reactome:R-RNO-112382|mint:MINT-7277650(identity)	-	comment:mint|function:"SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex)"	-	figure legend:f2a|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7108(spofr-sf_9)|taxid:7108(Spodoptera frugiperda insect cells)	-	2009/10/05	2014/10/16	rogid:5kaSyBAZ8eag2OUs24Sci+iN5+Y10116	rogid:Ngvkh3YoddZoutF3Vgwdi2b6xz410116	intact-crc:496874D09E56C00C|rigid:wyaymlOPHBQwXcluaX9370cCi18	false	flag tag:?-?(MINT-7277633)	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q63187	uniprotkb:Q93034	intact:EBI-8508308|intact:MINT-4598437	intact:EBI-1057139|uniprotkb:O14766|uniprotkb:Q9BZC6|uniprotkb:A8K960|ensembl:ENSP00000376808|ensembl:ENSP00000435376	psi-mi:eloa1_rat(display_long)|uniprotkb:Eloa(gene name)|psi-mi:Eloa(display_short)|uniprotkb:Elongin 110 kDa subunit(gene name synonym)|uniprotkb:RNA polymerase II transcription factor SIII subunit A1(gene name synonym)|uniprotkb:SIII p110(gene name synonym)|uniprotkb:Tceb3(gene name synonym)|uniprotkb:Transcription elongation factor B polypeptide 3(gene name synonym)	psi-mi:cul5_human(display_long)|uniprotkb:CUL5(gene name)|psi-mi:CUL5(display_short)|uniprotkb:VACM1(gene name synonym)|uniprotkb:Vasopressin-activated calcium-mobilizing receptor 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Yasukawa et al. (2008)	mint:MINT-7277467|pubmed:19037258|imex:IM-13833|doi:10.1038/emboj.2008.249	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8508366|mint:MINT-7277630|imex:IM-13833-8	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:3827|interpro:IPR017923|mint:Q63187|interpro:IPR035441|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0008023"(transcription elongation factor complex)|go:"GO:0070449"(elongin complex)|go:"GO:0090734"(site of DNA damage)|reactome:R-RNO-112382|reactome:R-RNO-674695|reactome:R-RNO-6796648|reactome:R-RNO-75955|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR003617(Transcription elongation factor, TFIIS/CRSP70, N-terminal, sub-type)|interpro:IPR010684(RNA polymerase II transcription factor SIII, subunit A)|mint:MINT-7277632(identity)	refseq:NP_003469.2|ensembl:ENSG00000166266(gene)|ensembl:ENST00000393094(transcript)|ensembl:ENST00000531427(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005829"(cytosol)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031466"(Cul5-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0038128"(ERBB2 signaling pathway)|go:"GO:0090734"(site of DNA damage)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|interpro:IPR001373(Cullin, N-terminal region)|interpro:IPR016157(Cullin, conserved site)|interpro:IPR016158(Cullin homology)|interpro:IPR016159(Cullin repeat-like)|interpro:IPR019559|interpro:IPR036317|interpro:IPR036388|interpro:IPR036390|mint:Q93034|rcsb pdb:3DPL|rcsb pdb:3DQV|rcsb pdb:4JGH|rcsb pdb:4N9F|rcsb pdb:6V9I|reactome:R-HSA-180585|reactome:R-HSA-8863795|reactome:R-HSA-8951664|reactome:R-HSA-9705462|reactome:R-HSA-983168|dip:DIP-43696N|mint:MINT-7277636(identity)	-	comment:mint|function:"SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex)"	-	figure legend:f2a|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7108(spofr-sf_9)|taxid:7108(Spodoptera frugiperda insect cells)	-	2009/10/05	2014/10/16	rogid:5kaSyBAZ8eag2OUs24Sci+iN5+Y10116	rogid:rmqOrKvxsALWuSvEcrPXxtNrcpc9606	intact-crc:496874D09E56C00C|rigid:wyaymlOPHBQwXcluaX9370cCi18	false	flag tag:?-?(MINT-7277633)	ha tag:?-?(MINT-7277637)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q63187	uniprotkb:P62878	intact:EBI-8508308|intact:MINT-4598437	intact:EBI-2507414|ensembl:ENSMUSP00000023036|uniprotkb:Q8N6Z8|uniprotkb:Q9D1S2|uniprotkb:Q9WUK9|uniprotkb:Q9Y254	psi-mi:eloa1_rat(display_long)|uniprotkb:Eloa(gene name)|psi-mi:Eloa(display_short)|uniprotkb:Elongin 110 kDa subunit(gene name synonym)|uniprotkb:RNA polymerase II transcription factor SIII subunit A1(gene name synonym)|uniprotkb:SIII p110(gene name synonym)|uniprotkb:Tceb3(gene name synonym)|uniprotkb:Transcription elongation factor B polypeptide 3(gene name synonym)	psi-mi:rbx1_mouse(display_long)|uniprotkb:RING finger protein 75(gene name synonym)|uniprotkb:RING-box protein 1(gene name synonym)|uniprotkb:Rbx1(gene name)|psi-mi:Rbx1(display_short)|uniprotkb:E3 ubiquitin-protein transferase RBX1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Yasukawa et al. (2008)	mint:MINT-7277467|pubmed:19037258|imex:IM-13833|doi:10.1038/emboj.2008.249	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8508366|mint:MINT-7277630|imex:IM-13833-8	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:3827|interpro:IPR017923|mint:Q63187|interpro:IPR035441|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0008023"(transcription elongation factor complex)|go:"GO:0070449"(elongin complex)|go:"GO:0090734"(site of DNA damage)|reactome:R-RNO-112382|reactome:R-RNO-674695|reactome:R-RNO-6796648|reactome:R-RNO-75955|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR003617(Transcription elongation factor, TFIIS/CRSP70, N-terminal, sub-type)|interpro:IPR010684(RNA polymerase II transcription factor SIII, subunit A)|mint:MINT-7277632(identity)	go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045116"(protein neddylation)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061663"(NEDD8 ligase activity)|go:"GO:0034450"(ubiquitin-ubiquitin ligase activity)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0097602"(cullin family protein binding)|go:"GO:1902499"(positive regulation of protein autoubiquitination)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR024766|mint:P62878|rcsb pdb:4A0C|rcsb pdb:4A0K|rcsb pdb:4A0L|reactome:R-MMU-110314|reactome:R-MMU-1170546|reactome:R-MMU-1234176|reactome:R-MMU-195253|reactome:R-MMU-4641258|reactome:R-MMU-5610780|reactome:R-MMU-5610785|reactome:R-MMU-5632684|reactome:R-MMU-5658442|reactome:R-MMU-5696394|reactome:R-MMU-5696395|reactome:R-MMU-5696400|reactome:R-MMU-6781823|reactome:R-MMU-6782135|reactome:R-MMU-6782210|reactome:R-MMU-68949|reactome:R-MMU-8854050|reactome:R-MMU-8932339|reactome:R-MMU-8939902|reactome:R-MMU-8951664|reactome:R-MMU-9020702|reactome:R-MMU-9708530|reactome:R-MMU-983168|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005680"(anaphase-promoting complex)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0008190"(eukaryotic initiation factor 4E binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030891"(VCB complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031462"(Cul2-RING ubiquitin ligase complex)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|ensembl:ENSMUSG00000022400(gene)|go:"GO:0031464"(Cul4A-RING E3 ubiquitin ligase complex)|ensembl:ENSMUST00000023036(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0031465"(Cul4B-RING E3 ubiquitin ligase complex)|go:"GO:0031466"(Cul5-RING ubiquitin ligase complex)|go:"GO:0031467"(Cul7-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|refseq:NP_062686.1|mint:MINT-7277644(identity)	-	comment:mint|function:"SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex)"	-	figure legend:f2a|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7108(spofr-sf_9)|taxid:7108(Spodoptera frugiperda insect cells)	-	2009/10/05	2014/10/16	rogid:5kaSyBAZ8eag2OUs24Sci+iN5+Y10116	rogid:pSaSNRZo+QudTPXOLUlksOj3smM10090	intact-crc:496874D09E56C00C|rigid:wyaymlOPHBQwXcluaX9370cCi18	false	flag tag:?-?(MINT-7277633)	myc tag:?-?(MINT-7277645)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q93034	uniprotkb:Q63187	intact:EBI-1057139|uniprotkb:O14766|uniprotkb:Q9BZC6|uniprotkb:A8K960|ensembl:ENSP00000376808|ensembl:ENSP00000435376	intact:EBI-8508308|intact:MINT-4598437	psi-mi:cul5_human(display_long)|uniprotkb:CUL5(gene name)|psi-mi:CUL5(display_short)|uniprotkb:VACM1(gene name synonym)|uniprotkb:Vasopressin-activated calcium-mobilizing receptor 1(gene name synonym)	psi-mi:eloa1_rat(display_long)|uniprotkb:Eloa(gene name)|psi-mi:Eloa(display_short)|uniprotkb:Elongin 110 kDa subunit(gene name synonym)|uniprotkb:RNA polymerase II transcription factor SIII subunit A1(gene name synonym)|uniprotkb:SIII p110(gene name synonym)|uniprotkb:Tceb3(gene name synonym)|uniprotkb:Transcription elongation factor B polypeptide 3(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Yasukawa et al. (2008)	mint:MINT-7277467|pubmed:19037258|imex:IM-13833|doi:10.1038/emboj.2008.249	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8508330|mint:MINT-7277580|imex:IM-13833-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003469.2|ensembl:ENSG00000166266(gene)|ensembl:ENST00000393094(transcript)|ensembl:ENST00000531427(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005829"(cytosol)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031466"(Cul5-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0038128"(ERBB2 signaling pathway)|go:"GO:0090734"(site of DNA damage)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|interpro:IPR001373(Cullin, N-terminal region)|interpro:IPR016157(Cullin, conserved site)|interpro:IPR016158(Cullin homology)|interpro:IPR016159(Cullin repeat-like)|interpro:IPR019559|interpro:IPR036317|interpro:IPR036388|interpro:IPR036390|mint:Q93034|rcsb pdb:3DPL|rcsb pdb:3DQV|rcsb pdb:4JGH|rcsb pdb:4N9F|rcsb pdb:6V9I|reactome:R-HSA-180585|reactome:R-HSA-8863795|reactome:R-HSA-8951664|reactome:R-HSA-9705462|reactome:R-HSA-983168|dip:DIP-43696N|mint:MINT-7277586(identity)	rgd:3827|interpro:IPR017923|mint:Q63187|interpro:IPR035441|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0008023"(transcription elongation factor complex)|go:"GO:0070449"(elongin complex)|go:"GO:0090734"(site of DNA damage)|reactome:R-RNO-112382|reactome:R-RNO-674695|reactome:R-RNO-6796648|reactome:R-RNO-75955|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR003617(Transcription elongation factor, TFIIS/CRSP70, N-terminal, sub-type)|interpro:IPR010684(RNA polymerase II transcription factor SIII, subunit A)|mint:MINT-7277601(identity)	-	-	comment:mint|function:"SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex)"	comment:homomint|comment:mint|figure legend:f2a f3b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7108(spofr-sf_9)|taxid:7108(Spodoptera frugiperda insect cells)	-	2009/10/05	2014/10/16	rogid:rmqOrKvxsALWuSvEcrPXxtNrcpc9606	rogid:5kaSyBAZ8eag2OUs24Sci+iN5+Y10116	intact-crc:1D28786454C938B3|rigid:wyaymlOPHBQwXcluaX9370cCi18	false	ha tag:?-?(MINT-7277587)	flag tag:?-?(MINT-7277602)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q93034	uniprotkb:P62870	intact:EBI-1057139|uniprotkb:O14766|uniprotkb:Q9BZC6|uniprotkb:A8K960|ensembl:ENSP00000376808|ensembl:ENSP00000435376	intact:EBI-918620|uniprotkb:Q63529|uniprotkb:Q80W20|ensembl:ENSRNOP00000072621	psi-mi:cul5_human(display_long)|uniprotkb:CUL5(gene name)|psi-mi:CUL5(display_short)|uniprotkb:VACM1(gene name synonym)|uniprotkb:Vasopressin-activated calcium-mobilizing receptor 1(gene name synonym)	psi-mi:elob_rat(display_long)|uniprotkb:Elob(gene name)|psi-mi:Elob(display_short)|uniprotkb:Elongin 18 kDa subunit(gene name synonym)|uniprotkb:RNA polymerase II transcription factor SIII subunit B(gene name synonym)|uniprotkb:SIII p18(gene name synonym)|uniprotkb:Tceb2(gene name synonym)|uniprotkb:Transcription elongation factor B polypeptide 2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Yasukawa et al. (2008)	mint:MINT-7277467|pubmed:19037258|imex:IM-13833|doi:10.1038/emboj.2008.249	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8508330|mint:MINT-7277580|imex:IM-13833-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003469.2|ensembl:ENSG00000166266(gene)|ensembl:ENST00000393094(transcript)|ensembl:ENST00000531427(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005829"(cytosol)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031466"(Cul5-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0038128"(ERBB2 signaling pathway)|go:"GO:0090734"(site of DNA damage)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|interpro:IPR001373(Cullin, N-terminal region)|interpro:IPR016157(Cullin, conserved site)|interpro:IPR016158(Cullin homology)|interpro:IPR016159(Cullin repeat-like)|interpro:IPR019559|interpro:IPR036317|interpro:IPR036388|interpro:IPR036390|mint:Q93034|rcsb pdb:3DPL|rcsb pdb:3DQV|rcsb pdb:4JGH|rcsb pdb:4N9F|rcsb pdb:6V9I|reactome:R-HSA-180585|reactome:R-HSA-8863795|reactome:R-HSA-8951664|reactome:R-HSA-9705462|reactome:R-HSA-983168|dip:DIP-43696N|mint:MINT-7277586(identity)	rgd:621200|refseq:NP_112391.1|ensembl:ENSRNOG00000004814(gene)|ensembl:ENSRNOT00000087768(transcript)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030891"(VCB complex)|go:"GO:0031462"(Cul2-RING ubiquitin ligase complex)|go:"GO:0031466"(Cul5-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070449"(elongin complex)|interpro:IPR000626(Ubiquitin)|interpro:IPR029071|interpro:IPR039049|mint:P62870|reactome:R-RNO-112382|reactome:R-RNO-1234176|reactome:R-RNO-674695|reactome:R-RNO-6796648|reactome:R-RNO-75955|reactome:R-RNO-8951664|reactome:R-RNO-9705462|reactome:R-RNO-983168|mint:MINT-7277584(identity)	-	-	-	comment:homomint|comment:mint|figure legend:f2a f3b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7108(spofr-sf_9)|taxid:7108(Spodoptera frugiperda insect cells)	-	2009/10/05	2014/10/16	rogid:rmqOrKvxsALWuSvEcrPXxtNrcpc9606	rogid:7W4I9AcvS1GK89dMmBOImMYNgLY10116	intact-crc:1D28786454C938B3|rigid:wyaymlOPHBQwXcluaX9370cCi18	false	ha tag:?-?(MINT-7277587)	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q93034	uniprotkb:Q9WTZ1	intact:EBI-1057139|uniprotkb:O14766|uniprotkb:Q9BZC6|uniprotkb:A8K960|ensembl:ENSP00000376808|ensembl:ENSP00000435376	intact:EBI-2659373|uniprotkb:Q3UKF8|ensembl:ENSMUSP00000052856	psi-mi:cul5_human(display_long)|uniprotkb:CUL5(gene name)|psi-mi:CUL5(display_short)|uniprotkb:VACM1(gene name synonym)|uniprotkb:Vasopressin-activated calcium-mobilizing receptor 1(gene name synonym)	psi-mi:rbx2_mouse(display_long)|uniprotkb:RING finger protein 7(gene name synonym)|uniprotkb:Sensitive to apoptosis gene protein(gene name synonym)|uniprotkb:Rbx2(gene name synonym)|uniprotkb:Sag(gene name synonym)|uniprotkb:Rnf7(gene name)|psi-mi:Rnf7(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Yasukawa et al. (2008)	mint:MINT-7277467|pubmed:19037258|imex:IM-13833|doi:10.1038/emboj.2008.249	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8508330|mint:MINT-7277580|imex:IM-13833-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003469.2|ensembl:ENSG00000166266(gene)|ensembl:ENST00000393094(transcript)|ensembl:ENST00000531427(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005829"(cytosol)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031466"(Cul5-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0038128"(ERBB2 signaling pathway)|go:"GO:0090734"(site of DNA damage)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|interpro:IPR001373(Cullin, N-terminal region)|interpro:IPR016157(Cullin, conserved site)|interpro:IPR016158(Cullin homology)|interpro:IPR016159(Cullin repeat-like)|interpro:IPR019559|interpro:IPR036317|interpro:IPR036388|interpro:IPR036390|mint:Q93034|rcsb pdb:3DPL|rcsb pdb:3DQV|rcsb pdb:4JGH|rcsb pdb:4N9F|rcsb pdb:6V9I|reactome:R-HSA-180585|reactome:R-HSA-8863795|reactome:R-HSA-8951664|reactome:R-HSA-9705462|reactome:R-HSA-983168|dip:DIP-43696N|mint:MINT-7277586(identity)	refseq:NP_035409.1|refseq:NP_001298064.1|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021799"(cerebral cortex radially oriented cell migration)|go:"GO:0021942"(radial glia guided migration of Purkinje cell)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031466"(Cul5-RING ubiquitin ligase complex)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045116"(protein neddylation)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061663"(NEDD8 ligase activity)|go:"GO:0097602"(cullin family protein binding)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR024766|mint:Q9WTZ1|rcsb pdb:6V9I|reactome:R-MMU-8951664|reactome:R-MMU-9705462|reactome:R-MMU-983168|go:"GO:0008631"(intrinsic apoptotic signaling pathway in response to oxidative stress)|ensembl:ENSMUSG00000051234(gene)|ensembl:ENSMUST00000057500(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0008270"(zinc ion binding)|mint:MINT-7277594(identity)	-	-	-	comment:homomint|comment:mint|figure legend:f2a f3b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7108(spofr-sf_9)|taxid:7108(Spodoptera frugiperda insect cells)	-	2009/10/05	2014/10/16	rogid:rmqOrKvxsALWuSvEcrPXxtNrcpc9606	rogid:Y/YRLbcyQ60cywUOcMKX+bQ1ayA10090	intact-crc:1D28786454C938B3|rigid:wyaymlOPHBQwXcluaX9370cCi18	false	ha tag:?-?(MINT-7277587)	myc tag:?-?(MINT-7277595)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q93034	uniprotkb:P83941	intact:EBI-1057139|uniprotkb:O14766|uniprotkb:Q9BZC6|uniprotkb:A8K960|ensembl:ENSP00000376808|ensembl:ENSP00000435376	intact:EBI-398626|uniprotkb:Q63182|ensembl:ENSRNOP00000067410|ensembl:ENSRNOP00000069739|ensembl:ENSRNOP00000071456	psi-mi:cul5_human(display_long)|uniprotkb:CUL5(gene name)|psi-mi:CUL5(display_short)|uniprotkb:VACM1(gene name synonym)|uniprotkb:Vasopressin-activated calcium-mobilizing receptor 1(gene name synonym)	psi-mi:eloc_rat(display_long)|uniprotkb:Eloc(gene name)|psi-mi:Eloc(display_short)|uniprotkb:Elongin 15 kDa subunit(gene name synonym)|uniprotkb:RNA polymerase II transcription factor SIII subunit C(gene name synonym)|uniprotkb:SIII p15(gene name synonym)|uniprotkb:Stromal membrane-associated protein SMAP1B homolog(gene name synonym)|uniprotkb:Tceb1(gene name synonym)|uniprotkb:Transcription elongation factor B polypeptide 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Yasukawa et al. (2008)	mint:MINT-7277467|pubmed:19037258|imex:IM-13833|doi:10.1038/emboj.2008.249	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8508330|mint:MINT-7277580|imex:IM-13833-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003469.2|ensembl:ENSG00000166266(gene)|ensembl:ENST00000393094(transcript)|ensembl:ENST00000531427(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005829"(cytosol)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031466"(Cul5-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0038128"(ERBB2 signaling pathway)|go:"GO:0090734"(site of DNA damage)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|interpro:IPR001373(Cullin, N-terminal region)|interpro:IPR016157(Cullin, conserved site)|interpro:IPR016158(Cullin homology)|interpro:IPR016159(Cullin repeat-like)|interpro:IPR019559|interpro:IPR036317|interpro:IPR036388|interpro:IPR036390|mint:Q93034|rcsb pdb:3DPL|rcsb pdb:3DQV|rcsb pdb:4JGH|rcsb pdb:4N9F|rcsb pdb:6V9I|reactome:R-HSA-180585|reactome:R-HSA-8863795|reactome:R-HSA-8951664|reactome:R-HSA-9705462|reactome:R-HSA-983168|dip:DIP-43696N|mint:MINT-7277586(identity)	rgd:620658|refseq:NP_072115.1|refseq:XP_006237786.1|refseq:NP_001257490.1|refseq:NP_001257491.1|refseq:NP_001257492.1|reactome:R-RNO-674695|reactome:R-RNO-6796648|reactome:R-RNO-75955|reactome:R-RNO-8951664|reactome:R-RNO-9705462|reactome:R-RNO-983168|reactome:R-RNO-1234176|ensembl:ENSRNOG00000031730(gene)|ensembl:ENSRNOT00000050236(transcript)|ensembl:ENSRNOT00000082813(transcript)|ensembl:ENSRNOT00000090313(transcript)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030891"(VCB complex)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0070449"(elongin complex)|interpro:IPR001232(SKP1 component)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR016073(SKP1 component, POZ)|interpro:IPR039948|mint:P83941|reactome:R-RNO-112382|mint:MINT-7277582(identity)	-	-	-	comment:homomint|comment:mint|figure legend:f2a f3b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7108(spofr-sf_9)|taxid:7108(Spodoptera frugiperda insect cells)	-	2009/10/05	2014/10/16	rogid:rmqOrKvxsALWuSvEcrPXxtNrcpc9606	rogid:Ngvkh3YoddZoutF3Vgwdi2b6xz410116	intact-crc:1D28786454C938B3|rigid:wyaymlOPHBQwXcluaX9370cCi18	false	ha tag:?-?(MINT-7277587)	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q93034	uniprotkb:P62878	intact:EBI-1057139|uniprotkb:O14766|uniprotkb:Q9BZC6|uniprotkb:A8K960|ensembl:ENSP00000376808|ensembl:ENSP00000435376	intact:EBI-2507414|ensembl:ENSMUSP00000023036|uniprotkb:Q8N6Z8|uniprotkb:Q9D1S2|uniprotkb:Q9WUK9|uniprotkb:Q9Y254	psi-mi:cul5_human(display_long)|uniprotkb:CUL5(gene name)|psi-mi:CUL5(display_short)|uniprotkb:VACM1(gene name synonym)|uniprotkb:Vasopressin-activated calcium-mobilizing receptor 1(gene name synonym)	psi-mi:rbx1_mouse(display_long)|uniprotkb:RING finger protein 75(gene name synonym)|uniprotkb:RING-box protein 1(gene name synonym)|uniprotkb:Rbx1(gene name)|psi-mi:Rbx1(display_short)|uniprotkb:E3 ubiquitin-protein transferase RBX1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Yasukawa et al. (2008)	mint:MINT-7277467|pubmed:19037258|imex:IM-13833|doi:10.1038/emboj.2008.249	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8508330|mint:MINT-7277580|imex:IM-13833-7	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003469.2|ensembl:ENSG00000166266(gene)|ensembl:ENST00000393094(transcript)|ensembl:ENST00000531427(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005829"(cytosol)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031466"(Cul5-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0038128"(ERBB2 signaling pathway)|go:"GO:0090734"(site of DNA damage)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|interpro:IPR001373(Cullin, N-terminal region)|interpro:IPR016157(Cullin, conserved site)|interpro:IPR016158(Cullin homology)|interpro:IPR016159(Cullin repeat-like)|interpro:IPR019559|interpro:IPR036317|interpro:IPR036388|interpro:IPR036390|mint:Q93034|rcsb pdb:3DPL|rcsb pdb:3DQV|rcsb pdb:4JGH|rcsb pdb:4N9F|rcsb pdb:6V9I|reactome:R-HSA-180585|reactome:R-HSA-8863795|reactome:R-HSA-8951664|reactome:R-HSA-9705462|reactome:R-HSA-983168|dip:DIP-43696N|mint:MINT-7277586(identity)	go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045116"(protein neddylation)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061663"(NEDD8 ligase activity)|go:"GO:0034450"(ubiquitin-ubiquitin ligase activity)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0097602"(cullin family protein binding)|go:"GO:1902499"(positive regulation of protein autoubiquitination)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR024766|mint:P62878|rcsb pdb:4A0C|rcsb pdb:4A0K|rcsb pdb:4A0L|reactome:R-MMU-110314|reactome:R-MMU-1170546|reactome:R-MMU-1234176|reactome:R-MMU-195253|reactome:R-MMU-4641258|reactome:R-MMU-5610780|reactome:R-MMU-5610785|reactome:R-MMU-5632684|reactome:R-MMU-5658442|reactome:R-MMU-5696394|reactome:R-MMU-5696395|reactome:R-MMU-5696400|reactome:R-MMU-6781823|reactome:R-MMU-6782135|reactome:R-MMU-6782210|reactome:R-MMU-68949|reactome:R-MMU-8854050|reactome:R-MMU-8932339|reactome:R-MMU-8939902|reactome:R-MMU-8951664|reactome:R-MMU-9020702|reactome:R-MMU-9708530|reactome:R-MMU-983168|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005680"(anaphase-promoting complex)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0008190"(eukaryotic initiation factor 4E binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030891"(VCB complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031462"(Cul2-RING ubiquitin ligase complex)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|ensembl:ENSMUSG00000022400(gene)|go:"GO:0031464"(Cul4A-RING E3 ubiquitin ligase complex)|ensembl:ENSMUST00000023036(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0031465"(Cul4B-RING E3 ubiquitin ligase complex)|go:"GO:0031466"(Cul5-RING ubiquitin ligase complex)|go:"GO:0031467"(Cul7-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|refseq:NP_062686.1|mint:MINT-7277590(identity)	-	-	-	comment:homomint|comment:mint|figure legend:f2a f3b|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7108(spofr-sf_9)|taxid:7108(Spodoptera frugiperda insect cells)	-	2009/10/05	2014/10/16	rogid:rmqOrKvxsALWuSvEcrPXxtNrcpc9606	rogid:pSaSNRZo+QudTPXOLUlksOj3smM10090	intact-crc:1D28786454C938B3|rigid:wyaymlOPHBQwXcluaX9370cCi18	false	ha tag:?-?(MINT-7277587)	myc tag:?-?(MINT-7277591)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q63187	uniprotkb:P83941	intact:EBI-8508308|intact:MINT-4598437	intact:EBI-398626|uniprotkb:Q63182|ensembl:ENSRNOP00000067410|ensembl:ENSRNOP00000069739|ensembl:ENSRNOP00000071456	psi-mi:eloa1_rat(display_long)|uniprotkb:Eloa(gene name)|psi-mi:Eloa(display_short)|uniprotkb:Elongin 110 kDa subunit(gene name synonym)|uniprotkb:RNA polymerase II transcription factor SIII subunit A1(gene name synonym)|uniprotkb:SIII p110(gene name synonym)|uniprotkb:Tceb3(gene name synonym)|uniprotkb:Transcription elongation factor B polypeptide 3(gene name synonym)	psi-mi:eloc_rat(display_long)|uniprotkb:Eloc(gene name)|psi-mi:Eloc(display_short)|uniprotkb:Elongin 15 kDa subunit(gene name synonym)|uniprotkb:RNA polymerase II transcription factor SIII subunit C(gene name synonym)|uniprotkb:SIII p15(gene name synonym)|uniprotkb:Stromal membrane-associated protein SMAP1B homolog(gene name synonym)|uniprotkb:Tceb1(gene name synonym)|uniprotkb:Transcription elongation factor B polypeptide 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Yasukawa et al. (2008)	mint:MINT-7277467|pubmed:19037258|imex:IM-13833|doi:10.1038/emboj.2008.249	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8508402|mint:MINT-7277656|imex:IM-13833-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:3827|interpro:IPR017923|mint:Q63187|interpro:IPR035441|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0008023"(transcription elongation factor complex)|go:"GO:0070449"(elongin complex)|go:"GO:0090734"(site of DNA damage)|reactome:R-RNO-112382|reactome:R-RNO-674695|reactome:R-RNO-6796648|reactome:R-RNO-75955|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR003617(Transcription elongation factor, TFIIS/CRSP70, N-terminal, sub-type)|interpro:IPR010684(RNA polymerase II transcription factor SIII, subunit A)|mint:MINT-7277674(identity)	rgd:620658|refseq:NP_072115.1|refseq:XP_006237786.1|refseq:NP_001257490.1|refseq:NP_001257491.1|refseq:NP_001257492.1|reactome:R-RNO-674695|reactome:R-RNO-6796648|reactome:R-RNO-75955|reactome:R-RNO-8951664|reactome:R-RNO-9705462|reactome:R-RNO-983168|reactome:R-RNO-1234176|ensembl:ENSRNOG00000031730(gene)|ensembl:ENSRNOT00000050236(transcript)|ensembl:ENSRNOT00000082813(transcript)|ensembl:ENSRNOT00000090313(transcript)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030891"(VCB complex)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0070449"(elongin complex)|interpro:IPR001232(SKP1 component)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR016073(SKP1 component, POZ)|interpro:IPR039948|mint:P83941|reactome:R-RNO-112382|mint:MINT-7277658(identity)	-	comment:mint|function:"SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex)"	-	figure legend:f3a|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7108(spofr-sf_9)|taxid:7108(Spodoptera frugiperda insect cells)	-	2009/10/05	2014/10/16	rogid:5kaSyBAZ8eag2OUs24Sci+iN5+Y10116	rogid:Ngvkh3YoddZoutF3Vgwdi2b6xz410116	intact-crc:B4E48B3F83586598|rigid:kPIXzx0lHihrr+JdZm/3SpE41OU	false	flag tag:?-?(MINT-7277675)|mutation disrupting interaction:550-550(MINT-7277680)|mutation disrupting interaction:554-554(MINT-7277683)	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q63187	uniprotkb:Q9WTZ1	intact:EBI-8508308|intact:MINT-4598437	intact:EBI-2659373|uniprotkb:Q3UKF8|ensembl:ENSMUSP00000052856	psi-mi:eloa1_rat(display_long)|uniprotkb:Eloa(gene name)|psi-mi:Eloa(display_short)|uniprotkb:Elongin 110 kDa subunit(gene name synonym)|uniprotkb:RNA polymerase II transcription factor SIII subunit A1(gene name synonym)|uniprotkb:SIII p110(gene name synonym)|uniprotkb:Tceb3(gene name synonym)|uniprotkb:Transcription elongation factor B polypeptide 3(gene name synonym)	psi-mi:rbx2_mouse(display_long)|uniprotkb:RING finger protein 7(gene name synonym)|uniprotkb:Sensitive to apoptosis gene protein(gene name synonym)|uniprotkb:Rbx2(gene name synonym)|uniprotkb:Sag(gene name synonym)|uniprotkb:Rnf7(gene name)|psi-mi:Rnf7(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Yasukawa et al. (2008)	mint:MINT-7277467|pubmed:19037258|imex:IM-13833|doi:10.1038/emboj.2008.249	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8508402|mint:MINT-7277656|imex:IM-13833-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:3827|interpro:IPR017923|mint:Q63187|interpro:IPR035441|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0008023"(transcription elongation factor complex)|go:"GO:0070449"(elongin complex)|go:"GO:0090734"(site of DNA damage)|reactome:R-RNO-112382|reactome:R-RNO-674695|reactome:R-RNO-6796648|reactome:R-RNO-75955|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR003617(Transcription elongation factor, TFIIS/CRSP70, N-terminal, sub-type)|interpro:IPR010684(RNA polymerase II transcription factor SIII, subunit A)|mint:MINT-7277674(identity)	refseq:NP_035409.1|refseq:NP_001298064.1|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021799"(cerebral cortex radially oriented cell migration)|go:"GO:0021942"(radial glia guided migration of Purkinje cell)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031466"(Cul5-RING ubiquitin ligase complex)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045116"(protein neddylation)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061663"(NEDD8 ligase activity)|go:"GO:0097602"(cullin family protein binding)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR024766|mint:Q9WTZ1|rcsb pdb:6V9I|reactome:R-MMU-8951664|reactome:R-MMU-9705462|reactome:R-MMU-983168|go:"GO:0008631"(intrinsic apoptotic signaling pathway in response to oxidative stress)|ensembl:ENSMUSG00000051234(gene)|ensembl:ENSMUST00000057500(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0008270"(zinc ion binding)|mint:MINT-7277666(identity)	-	comment:mint|function:"SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex)"	-	figure legend:f3a|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7108(spofr-sf_9)|taxid:7108(Spodoptera frugiperda insect cells)	-	2009/10/05	2014/10/16	rogid:5kaSyBAZ8eag2OUs24Sci+iN5+Y10116	rogid:Y/YRLbcyQ60cywUOcMKX+bQ1ayA10090	intact-crc:B4E48B3F83586598|rigid:kPIXzx0lHihrr+JdZm/3SpE41OU	false	flag tag:?-?(MINT-7277675)|mutation disrupting interaction:550-550(MINT-7277680)|mutation disrupting interaction:554-554(MINT-7277683)	myc tag:?-?(MINT-7277667)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q63187	uniprotkb:P62870	intact:EBI-8508308|intact:MINT-4598437	intact:EBI-918620|uniprotkb:Q63529|uniprotkb:Q80W20|ensembl:ENSRNOP00000072621	psi-mi:eloa1_rat(display_long)|uniprotkb:Eloa(gene name)|psi-mi:Eloa(display_short)|uniprotkb:Elongin 110 kDa subunit(gene name synonym)|uniprotkb:RNA polymerase II transcription factor SIII subunit A1(gene name synonym)|uniprotkb:SIII p110(gene name synonym)|uniprotkb:Tceb3(gene name synonym)|uniprotkb:Transcription elongation factor B polypeptide 3(gene name synonym)	psi-mi:elob_rat(display_long)|uniprotkb:Elob(gene name)|psi-mi:Elob(display_short)|uniprotkb:Elongin 18 kDa subunit(gene name synonym)|uniprotkb:RNA polymerase II transcription factor SIII subunit B(gene name synonym)|uniprotkb:SIII p18(gene name synonym)|uniprotkb:Tceb2(gene name synonym)|uniprotkb:Transcription elongation factor B polypeptide 2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Yasukawa et al. (2008)	mint:MINT-7277467|pubmed:19037258|imex:IM-13833|doi:10.1038/emboj.2008.249	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8508402|mint:MINT-7277656|imex:IM-13833-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:3827|interpro:IPR017923|mint:Q63187|interpro:IPR035441|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0008023"(transcription elongation factor complex)|go:"GO:0070449"(elongin complex)|go:"GO:0090734"(site of DNA damage)|reactome:R-RNO-112382|reactome:R-RNO-674695|reactome:R-RNO-6796648|reactome:R-RNO-75955|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR003617(Transcription elongation factor, TFIIS/CRSP70, N-terminal, sub-type)|interpro:IPR010684(RNA polymerase II transcription factor SIII, subunit A)|mint:MINT-7277674(identity)	rgd:621200|refseq:NP_112391.1|ensembl:ENSRNOG00000004814(gene)|ensembl:ENSRNOT00000087768(transcript)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030891"(VCB complex)|go:"GO:0031462"(Cul2-RING ubiquitin ligase complex)|go:"GO:0031466"(Cul5-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070449"(elongin complex)|interpro:IPR000626(Ubiquitin)|interpro:IPR029071|interpro:IPR039049|mint:P62870|reactome:R-RNO-112382|reactome:R-RNO-1234176|reactome:R-RNO-674695|reactome:R-RNO-6796648|reactome:R-RNO-75955|reactome:R-RNO-8951664|reactome:R-RNO-9705462|reactome:R-RNO-983168|mint:MINT-7277660(identity)	-	comment:mint|function:"SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex)"	-	figure legend:f3a|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7108(spofr-sf_9)|taxid:7108(Spodoptera frugiperda insect cells)	-	2009/10/05	2014/10/16	rogid:5kaSyBAZ8eag2OUs24Sci+iN5+Y10116	rogid:7W4I9AcvS1GK89dMmBOImMYNgLY10116	intact-crc:B4E48B3F83586598|rigid:kPIXzx0lHihrr+JdZm/3SpE41OU	false	flag tag:?-?(MINT-7277675)|mutation disrupting interaction:550-550(MINT-7277680)|mutation disrupting interaction:554-554(MINT-7277683)	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q63187	uniprotkb:Q93034	intact:EBI-8508308|intact:MINT-4598437	intact:EBI-1057139|uniprotkb:O14766|uniprotkb:Q9BZC6|uniprotkb:A8K960|ensembl:ENSP00000376808|ensembl:ENSP00000435376	psi-mi:eloa1_rat(display_long)|uniprotkb:Eloa(gene name)|psi-mi:Eloa(display_short)|uniprotkb:Elongin 110 kDa subunit(gene name synonym)|uniprotkb:RNA polymerase II transcription factor SIII subunit A1(gene name synonym)|uniprotkb:SIII p110(gene name synonym)|uniprotkb:Tceb3(gene name synonym)|uniprotkb:Transcription elongation factor B polypeptide 3(gene name synonym)	psi-mi:cul5_human(display_long)|uniprotkb:CUL5(gene name)|psi-mi:CUL5(display_short)|uniprotkb:VACM1(gene name synonym)|uniprotkb:Vasopressin-activated calcium-mobilizing receptor 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Yasukawa et al. (2008)	mint:MINT-7277467|pubmed:19037258|imex:IM-13833|doi:10.1038/emboj.2008.249	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8508402|mint:MINT-7277656|imex:IM-13833-9	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:3827|interpro:IPR017923|mint:Q63187|interpro:IPR035441|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0008023"(transcription elongation factor complex)|go:"GO:0070449"(elongin complex)|go:"GO:0090734"(site of DNA damage)|reactome:R-RNO-112382|reactome:R-RNO-674695|reactome:R-RNO-6796648|reactome:R-RNO-75955|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR003617(Transcription elongation factor, TFIIS/CRSP70, N-terminal, sub-type)|interpro:IPR010684(RNA polymerase II transcription factor SIII, subunit A)|mint:MINT-7277674(identity)	refseq:NP_003469.2|ensembl:ENSG00000166266(gene)|ensembl:ENST00000393094(transcript)|ensembl:ENST00000531427(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005829"(cytosol)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031466"(Cul5-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0038128"(ERBB2 signaling pathway)|go:"GO:0090734"(site of DNA damage)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|interpro:IPR001373(Cullin, N-terminal region)|interpro:IPR016157(Cullin, conserved site)|interpro:IPR016158(Cullin homology)|interpro:IPR016159(Cullin repeat-like)|interpro:IPR019559|interpro:IPR036317|interpro:IPR036388|interpro:IPR036390|mint:Q93034|rcsb pdb:3DPL|rcsb pdb:3DQV|rcsb pdb:4JGH|rcsb pdb:4N9F|rcsb pdb:6V9I|reactome:R-HSA-180585|reactome:R-HSA-8863795|reactome:R-HSA-8951664|reactome:R-HSA-9705462|reactome:R-HSA-983168|dip:DIP-43696N|mint:MINT-7277670(identity)	-	comment:mint|function:"SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex)"	-	figure legend:f3a|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7108(spofr-sf_9)|taxid:7108(Spodoptera frugiperda insect cells)	-	2009/10/05	2014/10/16	rogid:5kaSyBAZ8eag2OUs24Sci+iN5+Y10116	rogid:rmqOrKvxsALWuSvEcrPXxtNrcpc9606	intact-crc:B4E48B3F83586598|rigid:kPIXzx0lHihrr+JdZm/3SpE41OU	false	flag tag:?-?(MINT-7277675)|mutation disrupting interaction:550-550(MINT-7277680)|mutation disrupting interaction:554-554(MINT-7277683)	ha tag:?-?(MINT-7277671)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q63187	uniprotkb:Q93034	intact:EBI-8508308|intact:MINT-4598437	intact:EBI-1057139|uniprotkb:O14766|uniprotkb:Q9BZC6|uniprotkb:A8K960|ensembl:ENSP00000376808|ensembl:ENSP00000435376	psi-mi:eloa1_rat(display_long)|uniprotkb:Eloa(gene name)|psi-mi:Eloa(display_short)|uniprotkb:Elongin 110 kDa subunit(gene name synonym)|uniprotkb:RNA polymerase II transcription factor SIII subunit A1(gene name synonym)|uniprotkb:SIII p110(gene name synonym)|uniprotkb:Tceb3(gene name synonym)|uniprotkb:Transcription elongation factor B polypeptide 3(gene name synonym)	psi-mi:cul5_human(display_long)|uniprotkb:CUL5(gene name)|psi-mi:CUL5(display_short)|uniprotkb:VACM1(gene name synonym)|uniprotkb:Vasopressin-activated calcium-mobilizing receptor 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Yasukawa et al. (2008)	mint:MINT-7277467|pubmed:19037258|imex:IM-13833|doi:10.1038/emboj.2008.249	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8508440|mint:MINT-7277688|imex:IM-13833-10	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:3827|interpro:IPR017923|mint:Q63187|interpro:IPR035441|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0008023"(transcription elongation factor complex)|go:"GO:0070449"(elongin complex)|go:"GO:0090734"(site of DNA damage)|reactome:R-RNO-112382|reactome:R-RNO-674695|reactome:R-RNO-6796648|reactome:R-RNO-75955|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR003617(Transcription elongation factor, TFIIS/CRSP70, N-terminal, sub-type)|interpro:IPR010684(RNA polymerase II transcription factor SIII, subunit A)|mint:MINT-7277690(identity)	refseq:NP_003469.2|ensembl:ENSG00000166266(gene)|ensembl:ENST00000393094(transcript)|ensembl:ENST00000531427(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005829"(cytosol)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031466"(Cul5-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0038128"(ERBB2 signaling pathway)|go:"GO:0090734"(site of DNA damage)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|interpro:IPR001373(Cullin, N-terminal region)|interpro:IPR016157(Cullin, conserved site)|interpro:IPR016158(Cullin homology)|interpro:IPR016159(Cullin repeat-like)|interpro:IPR019559|interpro:IPR036317|interpro:IPR036388|interpro:IPR036390|mint:Q93034|rcsb pdb:3DPL|rcsb pdb:3DQV|rcsb pdb:4JGH|rcsb pdb:4N9F|rcsb pdb:6V9I|reactome:R-HSA-180585|reactome:R-HSA-8863795|reactome:R-HSA-8951664|reactome:R-HSA-9705462|reactome:R-HSA-983168|dip:DIP-43696N|mint:MINT-7277698(identity)	-	comment:mint|function:"SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex)"	-	figure legend:f3a|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7108(spofr-sf_9)|taxid:7108(Spodoptera frugiperda insect cells)	-	2009/10/05	2014/10/16	rogid:5kaSyBAZ8eag2OUs24Sci+iN5+Y10116	rogid:rmqOrKvxsALWuSvEcrPXxtNrcpc9606	intact-crc:89F20D5DB796AFB5|rigid:kPIXzx0lHihrr+JdZm/3SpE41OU	false	mutation disrupting interaction:549-558(MINT-7277693)|flag tag:?-?(MINT-7277695)|mutation disrupting interaction:554-554(MINT-7277691)	ha tag:?-?(MINT-7277699)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q63187	uniprotkb:P62870	intact:EBI-8508308|intact:MINT-4598437	intact:EBI-918620|uniprotkb:Q63529|uniprotkb:Q80W20|ensembl:ENSRNOP00000072621	psi-mi:eloa1_rat(display_long)|uniprotkb:Eloa(gene name)|psi-mi:Eloa(display_short)|uniprotkb:Elongin 110 kDa subunit(gene name synonym)|uniprotkb:RNA polymerase II transcription factor SIII subunit A1(gene name synonym)|uniprotkb:SIII p110(gene name synonym)|uniprotkb:Tceb3(gene name synonym)|uniprotkb:Transcription elongation factor B polypeptide 3(gene name synonym)	psi-mi:elob_rat(display_long)|uniprotkb:Elob(gene name)|psi-mi:Elob(display_short)|uniprotkb:Elongin 18 kDa subunit(gene name synonym)|uniprotkb:RNA polymerase II transcription factor SIII subunit B(gene name synonym)|uniprotkb:SIII p18(gene name synonym)|uniprotkb:Tceb2(gene name synonym)|uniprotkb:Transcription elongation factor B polypeptide 2(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Yasukawa et al. (2008)	mint:MINT-7277467|pubmed:19037258|imex:IM-13833|doi:10.1038/emboj.2008.249	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8508440|mint:MINT-7277688|imex:IM-13833-10	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:3827|interpro:IPR017923|mint:Q63187|interpro:IPR035441|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0008023"(transcription elongation factor complex)|go:"GO:0070449"(elongin complex)|go:"GO:0090734"(site of DNA damage)|reactome:R-RNO-112382|reactome:R-RNO-674695|reactome:R-RNO-6796648|reactome:R-RNO-75955|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR003617(Transcription elongation factor, TFIIS/CRSP70, N-terminal, sub-type)|interpro:IPR010684(RNA polymerase II transcription factor SIII, subunit A)|mint:MINT-7277690(identity)	rgd:621200|refseq:NP_112391.1|ensembl:ENSRNOG00000004814(gene)|ensembl:ENSRNOT00000087768(transcript)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030891"(VCB complex)|go:"GO:0031462"(Cul2-RING ubiquitin ligase complex)|go:"GO:0031466"(Cul5-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070449"(elongin complex)|interpro:IPR000626(Ubiquitin)|interpro:IPR029071|interpro:IPR039049|mint:P62870|reactome:R-RNO-112382|reactome:R-RNO-1234176|reactome:R-RNO-674695|reactome:R-RNO-6796648|reactome:R-RNO-75955|reactome:R-RNO-8951664|reactome:R-RNO-9705462|reactome:R-RNO-983168|mint:MINT-7277706(identity)	-	comment:mint|function:"SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex)"	-	figure legend:f3a|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7108(spofr-sf_9)|taxid:7108(Spodoptera frugiperda insect cells)	-	2009/10/05	2014/10/16	rogid:5kaSyBAZ8eag2OUs24Sci+iN5+Y10116	rogid:7W4I9AcvS1GK89dMmBOImMYNgLY10116	intact-crc:89F20D5DB796AFB5|rigid:kPIXzx0lHihrr+JdZm/3SpE41OU	false	mutation disrupting interaction:549-558(MINT-7277693)|flag tag:?-?(MINT-7277695)|mutation disrupting interaction:554-554(MINT-7277691)	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q63187	uniprotkb:P83941	intact:EBI-8508308|intact:MINT-4598437	intact:EBI-398626|uniprotkb:Q63182|ensembl:ENSRNOP00000067410|ensembl:ENSRNOP00000069739|ensembl:ENSRNOP00000071456	psi-mi:eloa1_rat(display_long)|uniprotkb:Eloa(gene name)|psi-mi:Eloa(display_short)|uniprotkb:Elongin 110 kDa subunit(gene name synonym)|uniprotkb:RNA polymerase II transcription factor SIII subunit A1(gene name synonym)|uniprotkb:SIII p110(gene name synonym)|uniprotkb:Tceb3(gene name synonym)|uniprotkb:Transcription elongation factor B polypeptide 3(gene name synonym)	psi-mi:eloc_rat(display_long)|uniprotkb:Eloc(gene name)|psi-mi:Eloc(display_short)|uniprotkb:Elongin 15 kDa subunit(gene name synonym)|uniprotkb:RNA polymerase II transcription factor SIII subunit C(gene name synonym)|uniprotkb:SIII p15(gene name synonym)|uniprotkb:Stromal membrane-associated protein SMAP1B homolog(gene name synonym)|uniprotkb:Tceb1(gene name synonym)|uniprotkb:Transcription elongation factor B polypeptide 1(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Yasukawa et al. (2008)	mint:MINT-7277467|pubmed:19037258|imex:IM-13833|doi:10.1038/emboj.2008.249	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8508440|mint:MINT-7277688|imex:IM-13833-10	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:3827|interpro:IPR017923|mint:Q63187|interpro:IPR035441|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0008023"(transcription elongation factor complex)|go:"GO:0070449"(elongin complex)|go:"GO:0090734"(site of DNA damage)|reactome:R-RNO-112382|reactome:R-RNO-674695|reactome:R-RNO-6796648|reactome:R-RNO-75955|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR003617(Transcription elongation factor, TFIIS/CRSP70, N-terminal, sub-type)|interpro:IPR010684(RNA polymerase II transcription factor SIII, subunit A)|mint:MINT-7277690(identity)	rgd:620658|refseq:NP_072115.1|refseq:XP_006237786.1|refseq:NP_001257490.1|refseq:NP_001257491.1|refseq:NP_001257492.1|reactome:R-RNO-674695|reactome:R-RNO-6796648|reactome:R-RNO-75955|reactome:R-RNO-8951664|reactome:R-RNO-9705462|reactome:R-RNO-983168|reactome:R-RNO-1234176|ensembl:ENSRNOG00000031730(gene)|ensembl:ENSRNOT00000050236(transcript)|ensembl:ENSRNOT00000082813(transcript)|ensembl:ENSRNOT00000090313(transcript)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030891"(VCB complex)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0070449"(elongin complex)|interpro:IPR001232(SKP1 component)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR016073(SKP1 component, POZ)|interpro:IPR039948|mint:P83941|reactome:R-RNO-112382|mint:MINT-7277708(identity)	-	comment:mint|function:"SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex)"	-	figure legend:f3a|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7108(spofr-sf_9)|taxid:7108(Spodoptera frugiperda insect cells)	-	2009/10/05	2014/10/16	rogid:5kaSyBAZ8eag2OUs24Sci+iN5+Y10116	rogid:Ngvkh3YoddZoutF3Vgwdi2b6xz410116	intact-crc:89F20D5DB796AFB5|rigid:kPIXzx0lHihrr+JdZm/3SpE41OU	false	mutation disrupting interaction:549-558(MINT-7277693)|flag tag:?-?(MINT-7277695)|mutation disrupting interaction:554-554(MINT-7277691)	-	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0113"(western blot)
uniprotkb:Q63187	uniprotkb:Q9WTZ1	intact:EBI-8508308|intact:MINT-4598437	intact:EBI-2659373|uniprotkb:Q3UKF8|ensembl:ENSMUSP00000052856	psi-mi:eloa1_rat(display_long)|uniprotkb:Eloa(gene name)|psi-mi:Eloa(display_short)|uniprotkb:Elongin 110 kDa subunit(gene name synonym)|uniprotkb:RNA polymerase II transcription factor SIII subunit A1(gene name synonym)|uniprotkb:SIII p110(gene name synonym)|uniprotkb:Tceb3(gene name synonym)|uniprotkb:Transcription elongation factor B polypeptide 3(gene name synonym)	psi-mi:rbx2_mouse(display_long)|uniprotkb:RING finger protein 7(gene name synonym)|uniprotkb:Sensitive to apoptosis gene protein(gene name synonym)|uniprotkb:Rbx2(gene name synonym)|uniprotkb:Sag(gene name synonym)|uniprotkb:Rnf7(gene name)|psi-mi:Rnf7(display_short)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Yasukawa et al. (2008)	mint:MINT-7277467|pubmed:19037258|imex:IM-13833|doi:10.1038/emboj.2008.249	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8508440|mint:MINT-7277688|imex:IM-13833-10	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:3827|interpro:IPR017923|mint:Q63187|interpro:IPR035441|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0008023"(transcription elongation factor complex)|go:"GO:0070449"(elongin complex)|go:"GO:0090734"(site of DNA damage)|reactome:R-RNO-112382|reactome:R-RNO-674695|reactome:R-RNO-6796648|reactome:R-RNO-75955|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR003617(Transcription elongation factor, TFIIS/CRSP70, N-terminal, sub-type)|interpro:IPR010684(RNA polymerase II transcription factor SIII, subunit A)|mint:MINT-7277690(identity)	refseq:NP_035409.1|refseq:NP_001298064.1|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0021799"(cerebral cortex radially oriented cell migration)|go:"GO:0021942"(radial glia guided migration of Purkinje cell)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031466"(Cul5-RING ubiquitin ligase complex)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045116"(protein neddylation)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061663"(NEDD8 ligase activity)|go:"GO:0097602"(cullin family protein binding)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR024766|mint:Q9WTZ1|rcsb pdb:6V9I|reactome:R-MMU-8951664|reactome:R-MMU-9705462|reactome:R-MMU-983168|go:"GO:0008631"(intrinsic apoptotic signaling pathway in response to oxidative stress)|ensembl:ENSMUSG00000051234(gene)|ensembl:ENSMUST00000057500(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0008270"(zinc ion binding)|mint:MINT-7277702(identity)	-	comment:mint|function:"SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex)"	-	figure legend:f3a|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:7108(spofr-sf_9)|taxid:7108(Spodoptera frugiperda insect cells)	-	2009/10/05	2014/10/16	rogid:5kaSyBAZ8eag2OUs24Sci+iN5+Y10116	rogid:Y/YRLbcyQ60cywUOcMKX+bQ1ayA10090	intact-crc:89F20D5DB796AFB5|rigid:kPIXzx0lHihrr+JdZm/3SpE41OU	false	mutation disrupting interaction:549-558(MINT-7277693)|flag tag:?-?(MINT-7277695)|mutation disrupting interaction:554-554(MINT-7277691)	myc tag:?-?(MINT-7277703)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:Q14241	uniprotkb:Q93034	intact:EBI-742350|uniprotkb:Q8IXH1|uniprotkb:B2R7Q8|ensembl:ENSP00000395574|ensembl:ENSP00000484196	intact:EBI-1057139|uniprotkb:O14766|uniprotkb:Q9BZC6|uniprotkb:A8K960|ensembl:ENSP00000376808|ensembl:ENSP00000435376	psi-mi:eloa1_human(display_long)|uniprotkb:ELOA(gene name)|psi-mi:ELOA(display_short)|uniprotkb:Elongin 110 kDa subunit(gene name synonym)|uniprotkb:RNA polymerase II transcription factor SIII subunit A1(gene name synonym)|uniprotkb:SIII p110(gene name synonym)|uniprotkb:TCEB3(gene name synonym)|uniprotkb:Transcription elongation factor B polypeptide 3(gene name synonym)|uniprotkb:MSTP059(orf name)	psi-mi:cul5_human(display_long)|uniprotkb:CUL5(gene name)|psi-mi:CUL5(display_short)|uniprotkb:VACM1(gene name synonym)|uniprotkb:Vasopressin-activated calcium-mobilizing receptor 1(gene name synonym)	psi-mi:"MI:0416"(fluorescence microscopy)	Yasukawa et al. (2008)	mint:MINT-7277467|pubmed:19037258|imex:IM-13833|doi:10.1038/emboj.2008.249	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-8508487|mint:MINT-7277713|imex:IM-13833-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_003189.2|ensembl:ENSG00000011007(gene)|ensembl:ENST00000418390(transcript)|ensembl:ENST00000613537(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0070449"(elongin complex)|go:"GO:0090734"(site of DNA damage)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR003617(Transcription elongation factor, TFIIS/CRSP70, N-terminal, sub-type)|interpro:IPR010684(RNA polymerase II transcription factor SIII, subunit A)|interpro:IPR017923|interpro:IPR035441|mint:Q14241|rcsb pdb:4HFX|reactome:R-HSA-112382|reactome:R-HSA-167152|reactome:R-HSA-167200|reactome:R-HSA-167238|reactome:R-HSA-167243|reactome:R-HSA-167246|reactome:R-HSA-167287|reactome:R-HSA-167290|reactome:R-HSA-674695|reactome:R-HSA-6796648|reactome:R-HSA-75955|mint:MINT-7277731(identity)	refseq:NP_003469.2|ensembl:ENSG00000166266(gene)|ensembl:ENST00000393094(transcript)|ensembl:ENST00000531427(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005829"(cytosol)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019005"(SCF ubiquitin ligase complex)|go:"GO:0031146"(SCF-dependent proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0031466"(Cul5-RING ubiquitin ligase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0038128"(ERBB2 signaling pathway)|go:"GO:0090734"(site of DNA damage)|go:"GO:0097193"(intrinsic apoptotic signaling pathway)|interpro:IPR001373(Cullin, N-terminal region)|interpro:IPR016157(Cullin, conserved site)|interpro:IPR016158(Cullin homology)|interpro:IPR016159(Cullin repeat-like)|interpro:IPR019559|interpro:IPR036317|interpro:IPR036388|interpro:IPR036390|mint:Q93034|rcsb pdb:3DPL|rcsb pdb:3DQV|rcsb pdb:4JGH|rcsb pdb:4N9F|rcsb pdb:6V9I|reactome:R-HSA-180585|reactome:R-HSA-8863795|reactome:R-HSA-8951664|reactome:R-HSA-9705462|reactome:R-HSA-983168|dip:DIP-43696N|mint:MINT-7277727(identity)	go:"GO:0005634"(nucleus)	-	-	figure legend:f4a|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:9606(human-hela)|taxid:9606(Homo sapiens epitheloid cervix carcinoma cells)	-	2009/10/05	2014/10/16	rogid:5gE87SPNXNcx+LQDo1Jwt/t9yfI9606	rogid:rmqOrKvxsALWuSvEcrPXxtNrcpc9606	intact-crc:4FF412F4BD1F8015|rigid:a8xTmoScvf5gDIsk2tEHkxRCTJk	false	-	-	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)
uniprotkb:P08775	uniprotkb:Q8CB77	intact:EBI-2549849|ensembl:ENSMUSP00000050771|uniprotkb:Q5F298	intact:EBI-6094632|uniprotkb:Q3UI38|uniprotkb:Q80VB2|uniprotkb:Q9R0Q5|ensembl:ENSMUSP00000030427	psi-mi:rpb1_mouse(display_long)|uniprotkb:Polr2a(gene name)|psi-mi:Polr2a(display_short)|uniprotkb:Rpii215(gene name synonym)|uniprotkb:Rpo2-1(gene name synonym)|uniprotkb:DNA-directed RNA polymerase II subunit A(gene name synonym)|uniprotkb:DNA-directed RNA polymerase III largest subunit(gene name synonym)	psi-mi:eloa1_mouse(display_long)|uniprotkb:Eloa(gene name)|psi-mi:Eloa(display_short)|uniprotkb:Elongin 110 kDa subunit(gene name synonym)|uniprotkb:RNA polymerase II transcription factor SIII subunit A1(gene name synonym)|uniprotkb:SIII p110(gene name synonym)|uniprotkb:Tceb3(gene name synonym)|uniprotkb:Transcription elongation factor B polypeptide 3(gene name synonym)	psi-mi:"MI:0007"(anti tag coimmunoprecipitation)	Yasukawa et al. (2008)	mint:MINT-7277467|pubmed:19037258|imex:IM-13833|doi:10.1038/emboj.2008.249	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8508510|mint:MINT-7277744|imex:IM-13833-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000005198(gene)|ensembl:ENSMUST00000058470(transcript)|go:"GO:0000791"(euchromatin)|go:"GO:0001046"(core promoter sequence-specific DNA binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003899"(DNA-directed 5'-3' RNA polymerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005665"(RNA polymerase II, core complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006353"(DNA-templated transcription, termination)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0019900"(kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0046872"(metal ion binding)|go:"GO:0071453"(cellular response to oxygen levels)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000684(RNA polymerase II, heptapeptide repeat, eukaryotic)|interpro:IPR000722(RNA polymerase, alpha subunit)|interpro:IPR006592(RNA polymerase, N-terminal)|interpro:IPR007066(RNA polymerase Rpb1, domain 3)|interpro:IPR007073(RNA polymerase Rpb1, domain 7)|interpro:IPR007075(RNA polymerase Rpb1, domain 6)|interpro:IPR007080(RNA polymerase Rpb1, domain 1)|interpro:IPR007081(RNA polymerase Rpb1, domain 5)|interpro:IPR007083(RNA polymerase Rpb1, domain 4)|interpro:IPR038120|interpro:IPR038593|interpro:IPR042102|mint:P08775|reactome:R-MMU-113418|reactome:R-MMU-5578749|reactome:R-MMU-674695|reactome:R-MMU-6781823|reactome:R-MMU-6782135|reactome:R-MMU-6782210|reactome:R-MMU-6796648|reactome:R-MMU-6803529|reactome:R-MMU-6807505|reactome:R-MMU-72086|reactome:R-MMU-72163|reactome:R-MMU-72165|reactome:R-MMU-72203|reactome:R-MMU-73776|reactome:R-MMU-73779|reactome:R-MMU-75953|reactome:R-MMU-75955|reactome:R-MMU-76042|reactome:R-MMU-77075|reactome:R-MMU-9018519|reactome:R-MMU-112382|refseq:NP_001277997.1|dip:DIP-46369N|mint:MINT-7277751(identity)	refseq:NP_038764.2|ensembl:ENSMUSG00000028668(gene)|ensembl:ENSMUST00000030427(transcript)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0008023"(transcription elongation factor complex)|go:"GO:0070449"(elongin complex)|go:"GO:0090734"(site of DNA damage)|interpro:IPR001810(Cyclin-like F-box)|interpro:IPR003617(Transcription elongation factor, TFIIS/CRSP70, N-terminal, sub-type)|interpro:IPR010684(RNA polymerase II transcription factor SIII, subunit A)|interpro:IPR017923|interpro:IPR035441|mint:Q8CB77|reactome:R-MMU-112382|reactome:R-MMU-674695|reactome:R-MMU-6796648|reactome:R-MMU-75955|mint:MINT-7277747(identity)	-	-	-	figure legend:f7|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-cce-es)|taxid:10090(Mus musculus)	-	2009/10/05	2014/10/16	rogid:kUX/HdU6Y2VHAGjySBcOxfS08XA10090	rogid:kQcIpkpxBQd614FnBELoMENjOAw10090	intact-crc:F118B586F88DFD70|rigid:uPL5NiGRn+LsYHxav+NLUjp1+SI	false	-	flag tag:?-?(MINT-7277748)	-	-	psi-mi:"MI:0113"(western blot)	psi-mi:"MI:0396"(predetermined participant)