#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P70335	uniprotkb:P61588	intact:EBI-989293|uniprotkb:Q8C3G4|uniprotkb:Q8C7H0|ensembl:ENSMUSP00000069549	intact:EBI-6930266|ensembl:ENSMUSP00000017288|uniprotkb:P52199|uniprotkb:Q6ZWS2	psi-mi:rock1_mouse(display_long)|uniprotkb:Rho-associated, coiled-coil-containing protein kinase 1(gene name synonym)|uniprotkb:p160 ROCK-1(gene name synonym)|uniprotkb:Rock1(gene name)|psi-mi:Rock1(display_short)|uniprotkb:Rho-associated, coiled-coil-containing protein kinase I(gene name synonym)	psi-mi:rnd3_mouse(display_long)|uniprotkb:Rnd3(gene name)|psi-mi:Rnd3(display_short)|uniprotkb:Arhe(gene name synonym)|uniprotkb:Rhoe(gene name synonym)|uniprotkb:Rho family GTPase 3(gene name synonym)|uniprotkb:Rnd3(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Komander et al. (2008)	pubmed:18946488|imex:IM-13799|mint:MINT-7293468|doi:10.1038/emboj.2008.226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8454342|mint:MINT-7293476|imex:IM-13799-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007159"(leukocyte cell-cell adhesion)|ensembl:ENSMUSG00000024290(gene)|ensembl:ENSMUST00000067947(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001726"(ruffle)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0003383"(apical constriction)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005814"(centriole)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0072518"(Rho-dependent protein serine/threonine kinase activity)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090521"(glomerular visceral epithelial cell migration)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0110061"(regulation of angiotensin-activated signaling pathway)|go:"GO:0140058"(neuron projection arborization)|go:"GO:1900223"(positive regulation of amyloid-beta clearance)|go:"GO:1900242"(regulation of synaptic vesicle endocytosis)|go:"GO:1901888"(regulation of cell junction assembly)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902992"(negative regulation of amyloid precursor protein catabolic process)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:1905205"(positive regulation of connective tissue replacement)|go:"GO:1990776"(response to angiotensin)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|go:"GO:0071559"(response to transforming growth factor beta)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR015008(Rho Binding)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020684|interpro:IPR037310|mint:P70335|reactome:R-MMU-111465|reactome:R-MMU-3928662|reactome:R-MMU-416482|reactome:R-MMU-416572|reactome:R-MMU-4420097|reactome:R-MMU-5627117|reactome:R-MMU-6798695|reactome:R-MMU-8980692|reactome:R-MMU-9013026|reactome:R-MMU-9013106|reactome:R-MMU-9013407|reactome:R-MMU-9013422|reactome:R-MMU-9696264|interpro:IPR011072(HR1 rho-binding repeat)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019828"(aspartic-type endopeptidase inhibitor activity)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0031175"(neuron projection development)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032059"(bleb)|go:"GO:0032060"(bleb assembly)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032970"(regulation of actin filament-based process)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0042326"(negative regulation of phosphorylation)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045616"(regulation of keratinocyte differentiation)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048598"(embryonic morphogenesis)|go:"GO:0050900"(leukocyte migration)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0051451"(myoblast migration)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0061157"(mRNA destabilization)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|refseq:NP_033097.1|refseq:XP_006525788.1|dip:DIP-35521N|mint:MINT-7293479(identity)	ensembl:ENSMUSG00000017144(gene)|ensembl:ENSMUST00000017288(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0007015"(actin filament organization)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016477"(cell migration)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030865"(cortical cytoskeleton organization)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0042995"(cell projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR041843|mint:P61588|rcsb pdb:1GWN|reactome:R-MMU-9696264|refseq:NP_083086.1|mint:MINT-7293478(identity)	-	-	-	figure legend:T1 F1 F2|comment:homomint|comment:mint|comment:ROCK1 protein taxid has not been specified|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/10/19	2014/10/16	rogid:BIAb7c+Ar8WI6cES/igerUjk1zc10090	rogid:nRE3V8nu01Om6bk+I97m3IubAJg10090	intact-crc:6BFA63BFB8ED5F05|rigid:4JO3olvTN8DRSBoDECHwTfn6++A	false	binding-associated region:1-406(MINT-7293486)	binding-associated region:1-200(MINT-7293490)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P70335	uniprotkb:P61588	intact:EBI-989293|uniprotkb:Q8C3G4|uniprotkb:Q8C7H0|ensembl:ENSMUSP00000069549	intact:EBI-6930266|ensembl:ENSMUSP00000017288|uniprotkb:P52199|uniprotkb:Q6ZWS2	psi-mi:rock1_mouse(display_long)|uniprotkb:Rho-associated, coiled-coil-containing protein kinase 1(gene name synonym)|uniprotkb:p160 ROCK-1(gene name synonym)|uniprotkb:Rock1(gene name)|psi-mi:Rock1(display_short)|uniprotkb:Rho-associated, coiled-coil-containing protein kinase I(gene name synonym)	psi-mi:rnd3_mouse(display_long)|uniprotkb:Rnd3(gene name)|psi-mi:Rnd3(display_short)|uniprotkb:Arhe(gene name synonym)|uniprotkb:Rhoe(gene name synonym)|uniprotkb:Rho family GTPase 3(gene name synonym)|uniprotkb:Rnd3(gene name synonym)	psi-mi:"MI:0096"(pull down)	Komander et al. (2008)	pubmed:18946488|imex:IM-13799|mint:MINT-7293468|doi:10.1038/emboj.2008.226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8454370|mint:MINT-7293497|imex:IM-13799-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007159"(leukocyte cell-cell adhesion)|ensembl:ENSMUSG00000024290(gene)|ensembl:ENSMUST00000067947(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001726"(ruffle)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0003383"(apical constriction)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005814"(centriole)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0072518"(Rho-dependent protein serine/threonine kinase activity)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090521"(glomerular visceral epithelial cell migration)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0110061"(regulation of angiotensin-activated signaling pathway)|go:"GO:0140058"(neuron projection arborization)|go:"GO:1900223"(positive regulation of amyloid-beta clearance)|go:"GO:1900242"(regulation of synaptic vesicle endocytosis)|go:"GO:1901888"(regulation of cell junction assembly)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902992"(negative regulation of amyloid precursor protein catabolic process)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:1905205"(positive regulation of connective tissue replacement)|go:"GO:1990776"(response to angiotensin)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|go:"GO:0071559"(response to transforming growth factor beta)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR015008(Rho Binding)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020684|interpro:IPR037310|mint:P70335|reactome:R-MMU-111465|reactome:R-MMU-3928662|reactome:R-MMU-416482|reactome:R-MMU-416572|reactome:R-MMU-4420097|reactome:R-MMU-5627117|reactome:R-MMU-6798695|reactome:R-MMU-8980692|reactome:R-MMU-9013026|reactome:R-MMU-9013106|reactome:R-MMU-9013407|reactome:R-MMU-9013422|reactome:R-MMU-9696264|interpro:IPR011072(HR1 rho-binding repeat)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019828"(aspartic-type endopeptidase inhibitor activity)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0031175"(neuron projection development)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032059"(bleb)|go:"GO:0032060"(bleb assembly)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032970"(regulation of actin filament-based process)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0042326"(negative regulation of phosphorylation)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045616"(regulation of keratinocyte differentiation)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048598"(embryonic morphogenesis)|go:"GO:0050900"(leukocyte migration)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0051451"(myoblast migration)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0061157"(mRNA destabilization)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|refseq:NP_033097.1|refseq:XP_006525788.1|dip:DIP-35521N|mint:MINT-7293499(identity)	ensembl:ENSMUSG00000017144(gene)|ensembl:ENSMUST00000017288(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0007015"(actin filament organization)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016477"(cell migration)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030865"(cortical cytoskeleton organization)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0042995"(cell projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR041843|mint:P61588|rcsb pdb:1GWN|reactome:R-MMU-9696264|refseq:NP_083086.1|mint:MINT-7293503(identity)	-	-	-	figure legend:F6B|comment:homomint|comment:mint|comment:ROCK1 protein taxid has not been specified|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/10/19	2014/10/16	rogid:BIAb7c+Ar8WI6cES/igerUjk1zc10090	rogid:nRE3V8nu01Om6bk+I97m3IubAJg10090	intact-crc:1F7A4FA5BB0EAA01|rigid:4JO3olvTN8DRSBoDECHwTfn6++A	false	his tag:?-?(MINT-7293514)|binding-associated region:1-406(MINT-7293500)	glutathione s tranferase tag:?-?(MINT-7293511)|mutation disrupting interaction:173-173(MINT-7293517)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0815"(confirmation by molecular weight)
uniprotkb:P61588	uniprotkb:P70335	intact:EBI-6930266|ensembl:ENSMUSP00000017288|uniprotkb:P52199|uniprotkb:Q6ZWS2	intact:EBI-989293|uniprotkb:Q8C3G4|uniprotkb:Q8C7H0|ensembl:ENSMUSP00000069549	psi-mi:rnd3_mouse(display_long)|uniprotkb:Rnd3(gene name)|psi-mi:Rnd3(display_short)|uniprotkb:Arhe(gene name synonym)|uniprotkb:Rhoe(gene name synonym)|uniprotkb:Rho family GTPase 3(gene name synonym)|uniprotkb:Rnd3(gene name synonym)	psi-mi:rock1_mouse(display_long)|uniprotkb:Rho-associated, coiled-coil-containing protein kinase 1(gene name synonym)|uniprotkb:p160 ROCK-1(gene name synonym)|uniprotkb:Rock1(gene name)|psi-mi:Rock1(display_short)|uniprotkb:Rho-associated, coiled-coil-containing protein kinase I(gene name synonym)	psi-mi:"MI:0096"(pull down)	Komander et al. (2008)	pubmed:18946488|imex:IM-13799|mint:MINT-7293468|doi:10.1038/emboj.2008.226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8454414|mint:MINT-7293521|imex:IM-13799-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000017144(gene)|ensembl:ENSMUST00000017288(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0007015"(actin filament organization)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016477"(cell migration)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030865"(cortical cytoskeleton organization)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0042995"(cell projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR041843|mint:P61588|rcsb pdb:1GWN|reactome:R-MMU-9696264|refseq:NP_083086.1|mint:MINT-7293523(identity)	go:"GO:0007159"(leukocyte cell-cell adhesion)|ensembl:ENSMUSG00000024290(gene)|ensembl:ENSMUST00000067947(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001726"(ruffle)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0003383"(apical constriction)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005814"(centriole)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0072518"(Rho-dependent protein serine/threonine kinase activity)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090521"(glomerular visceral epithelial cell migration)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0110061"(regulation of angiotensin-activated signaling pathway)|go:"GO:0140058"(neuron projection arborization)|go:"GO:1900223"(positive regulation of amyloid-beta clearance)|go:"GO:1900242"(regulation of synaptic vesicle endocytosis)|go:"GO:1901888"(regulation of cell junction assembly)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902992"(negative regulation of amyloid precursor protein catabolic process)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:1905205"(positive regulation of connective tissue replacement)|go:"GO:1990776"(response to angiotensin)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|go:"GO:0071559"(response to transforming growth factor beta)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR015008(Rho Binding)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020684|interpro:IPR037310|mint:P70335|reactome:R-MMU-111465|reactome:R-MMU-3928662|reactome:R-MMU-416482|reactome:R-MMU-416572|reactome:R-MMU-4420097|reactome:R-MMU-5627117|reactome:R-MMU-6798695|reactome:R-MMU-8980692|reactome:R-MMU-9013026|reactome:R-MMU-9013106|reactome:R-MMU-9013407|reactome:R-MMU-9013422|reactome:R-MMU-9696264|interpro:IPR011072(HR1 rho-binding repeat)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019828"(aspartic-type endopeptidase inhibitor activity)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0031175"(neuron projection development)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032059"(bleb)|go:"GO:0032060"(bleb assembly)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032970"(regulation of actin filament-based process)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0042326"(negative regulation of phosphorylation)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045616"(regulation of keratinocyte differentiation)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048598"(embryonic morphogenesis)|go:"GO:0050900"(leukocyte migration)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0051451"(myoblast migration)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0061157"(mRNA destabilization)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|refseq:NP_033097.1|refseq:XP_006525788.1|dip:DIP-35521N|mint:MINT-7293529(identity)	-	-	-	figure legend:F6B|comment:homomint|comment:mint|comment:ROCK1 protein taxid has not been specified|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/10/19	2014/10/16	rogid:nRE3V8nu01Om6bk+I97m3IubAJg10090	rogid:BIAb7c+Ar8WI6cES/igerUjk1zc10090	intact-crc:53094E09CA0FD986|rigid:4JO3olvTN8DRSBoDECHwTfn6++A	false	mutation disrupting interaction:192-192(MINT-7293536)|glutathione s tranferase tag:?-?(MINT-7293526)|mutation disrupting interaction:173-173(MINT-7293524)	his tag:?-?(MINT-7293530)|binding-associated region:1-406(MINT-7293532)	-	-	psi-mi:"MI:0815"(confirmation by molecular weight)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P70335	uniprotkb:P61588	intact:EBI-989293|uniprotkb:Q8C3G4|uniprotkb:Q8C7H0|ensembl:ENSMUSP00000069549	intact:EBI-6930266|ensembl:ENSMUSP00000017288|uniprotkb:P52199|uniprotkb:Q6ZWS2	psi-mi:rock1_mouse(display_long)|uniprotkb:Rho-associated, coiled-coil-containing protein kinase 1(gene name synonym)|uniprotkb:p160 ROCK-1(gene name synonym)|uniprotkb:Rock1(gene name)|psi-mi:Rock1(display_short)|uniprotkb:Rho-associated, coiled-coil-containing protein kinase I(gene name synonym)	psi-mi:rnd3_mouse(display_long)|uniprotkb:Rnd3(gene name)|psi-mi:Rnd3(display_short)|uniprotkb:Arhe(gene name synonym)|uniprotkb:Rhoe(gene name synonym)|uniprotkb:Rho family GTPase 3(gene name synonym)|uniprotkb:Rnd3(gene name synonym)	psi-mi:"MI:0096"(pull down)	Komander et al. (2008)	pubmed:18946488|imex:IM-13799|mint:MINT-7293468|doi:10.1038/emboj.2008.226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8454487|mint:MINT-7293558|imex:IM-13799-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007159"(leukocyte cell-cell adhesion)|ensembl:ENSMUSG00000024290(gene)|ensembl:ENSMUST00000067947(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001726"(ruffle)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0003383"(apical constriction)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005814"(centriole)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0072518"(Rho-dependent protein serine/threonine kinase activity)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090521"(glomerular visceral epithelial cell migration)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0110061"(regulation of angiotensin-activated signaling pathway)|go:"GO:0140058"(neuron projection arborization)|go:"GO:1900223"(positive regulation of amyloid-beta clearance)|go:"GO:1900242"(regulation of synaptic vesicle endocytosis)|go:"GO:1901888"(regulation of cell junction assembly)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902992"(negative regulation of amyloid precursor protein catabolic process)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:1905205"(positive regulation of connective tissue replacement)|go:"GO:1990776"(response to angiotensin)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|go:"GO:0071559"(response to transforming growth factor beta)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR015008(Rho Binding)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020684|interpro:IPR037310|mint:P70335|reactome:R-MMU-111465|reactome:R-MMU-3928662|reactome:R-MMU-416482|reactome:R-MMU-416572|reactome:R-MMU-4420097|reactome:R-MMU-5627117|reactome:R-MMU-6798695|reactome:R-MMU-8980692|reactome:R-MMU-9013026|reactome:R-MMU-9013106|reactome:R-MMU-9013407|reactome:R-MMU-9013422|reactome:R-MMU-9696264|interpro:IPR011072(HR1 rho-binding repeat)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019828"(aspartic-type endopeptidase inhibitor activity)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0031175"(neuron projection development)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032059"(bleb)|go:"GO:0032060"(bleb assembly)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032970"(regulation of actin filament-based process)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0042326"(negative regulation of phosphorylation)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045616"(regulation of keratinocyte differentiation)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048598"(embryonic morphogenesis)|go:"GO:0050900"(leukocyte migration)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0051451"(myoblast migration)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0061157"(mRNA destabilization)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|refseq:NP_033097.1|refseq:XP_006525788.1|dip:DIP-35521N|mint:MINT-7293560(identity)	ensembl:ENSMUSG00000017144(gene)|ensembl:ENSMUST00000017288(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0007015"(actin filament organization)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016477"(cell migration)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030865"(cortical cytoskeleton organization)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0042995"(cell projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR041843|mint:P61588|rcsb pdb:1GWN|reactome:R-MMU-9696264|refseq:NP_083086.1|mint:MINT-7293566(identity)	-	-	-	comment:homomint|comment:mint|comment:ROCK1 protein taxid has not been specified|figure legend:F6A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/10/19	2014/10/16	rogid:BIAb7c+Ar8WI6cES/igerUjk1zc10090	rogid:nRE3V8nu01Om6bk+I97m3IubAJg10090	intact-crc:B59060BC196325BC|rigid:4JO3olvTN8DRSBoDECHwTfn6++A	false	myc tag:?-?(MINT-7293563)|binding-associated region:1-420(MINT-7293561)	glutathione s tranferase tag:?-?(MINT-7293569)|mutation disrupting interaction:173-173(MINT-7293571)|mutation disrupting interaction:192-192(MINT-7293567)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)
uniprotkb:P70335	uniprotkb:P61588	intact:EBI-989293|uniprotkb:Q8C3G4|uniprotkb:Q8C7H0|ensembl:ENSMUSP00000069549	intact:EBI-6930266|ensembl:ENSMUSP00000017288|uniprotkb:P52199|uniprotkb:Q6ZWS2	psi-mi:rock1_mouse(display_long)|uniprotkb:Rho-associated, coiled-coil-containing protein kinase 1(gene name synonym)|uniprotkb:p160 ROCK-1(gene name synonym)|uniprotkb:Rock1(gene name)|psi-mi:Rock1(display_short)|uniprotkb:Rho-associated, coiled-coil-containing protein kinase I(gene name synonym)	psi-mi:rnd3_mouse(display_long)|uniprotkb:Rnd3(gene name)|psi-mi:Rnd3(display_short)|uniprotkb:Arhe(gene name synonym)|uniprotkb:Rhoe(gene name synonym)|uniprotkb:Rho family GTPase 3(gene name synonym)|uniprotkb:Rnd3(gene name synonym)	psi-mi:"MI:0096"(pull down)	Komander et al. (2008)	pubmed:18946488|imex:IM-13799|mint:MINT-7293468|doi:10.1038/emboj.2008.226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8454461|mint:MINT-7293540|imex:IM-13799-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007159"(leukocyte cell-cell adhesion)|ensembl:ENSMUSG00000024290(gene)|ensembl:ENSMUST00000067947(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001726"(ruffle)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0003383"(apical constriction)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005814"(centriole)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0072518"(Rho-dependent protein serine/threonine kinase activity)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090521"(glomerular visceral epithelial cell migration)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0110061"(regulation of angiotensin-activated signaling pathway)|go:"GO:0140058"(neuron projection arborization)|go:"GO:1900223"(positive regulation of amyloid-beta clearance)|go:"GO:1900242"(regulation of synaptic vesicle endocytosis)|go:"GO:1901888"(regulation of cell junction assembly)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902992"(negative regulation of amyloid precursor protein catabolic process)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:1905205"(positive regulation of connective tissue replacement)|go:"GO:1990776"(response to angiotensin)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|go:"GO:0071559"(response to transforming growth factor beta)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR015008(Rho Binding)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020684|interpro:IPR037310|mint:P70335|reactome:R-MMU-111465|reactome:R-MMU-3928662|reactome:R-MMU-416482|reactome:R-MMU-416572|reactome:R-MMU-4420097|reactome:R-MMU-5627117|reactome:R-MMU-6798695|reactome:R-MMU-8980692|reactome:R-MMU-9013026|reactome:R-MMU-9013106|reactome:R-MMU-9013407|reactome:R-MMU-9013422|reactome:R-MMU-9696264|interpro:IPR011072(HR1 rho-binding repeat)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019828"(aspartic-type endopeptidase inhibitor activity)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0031175"(neuron projection development)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032059"(bleb)|go:"GO:0032060"(bleb assembly)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032970"(regulation of actin filament-based process)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0042326"(negative regulation of phosphorylation)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045616"(regulation of keratinocyte differentiation)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048598"(embryonic morphogenesis)|go:"GO:0050900"(leukocyte migration)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0051451"(myoblast migration)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0061157"(mRNA destabilization)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|refseq:NP_033097.1|refseq:XP_006525788.1|dip:DIP-35521N|mint:MINT-7293542(identity)	ensembl:ENSMUSG00000017144(gene)|ensembl:ENSMUST00000017288(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0007015"(actin filament organization)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016477"(cell migration)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030865"(cortical cytoskeleton organization)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0042995"(cell projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR041843|mint:P61588|rcsb pdb:1GWN|reactome:R-MMU-9696264|refseq:NP_083086.1|mint:MINT-7293548(identity)	-	-	-	figure legend:F6B|comment:homomint|comment:mint|comment:ROCK1 protein taxid has not been specified|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/10/19	2014/10/16	rogid:BIAb7c+Ar8WI6cES/igerUjk1zc10090	rogid:nRE3V8nu01Om6bk+I97m3IubAJg10090	intact-crc:F5C02202C31ADDAC|rigid:4JO3olvTN8DRSBoDECHwTfn6++A	false	his tag:?-?(MINT-7293545)|binding-associated region:1-406(MINT-7293543)	mutation disrupting interaction:192-192(MINT-7293549)|glutathione s tranferase tag:?-?(MINT-7293551)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0815"(confirmation by molecular weight)
uniprotkb:P61588	uniprotkb:P70335	intact:EBI-6930266|ensembl:ENSMUSP00000017288|uniprotkb:P52199|uniprotkb:Q6ZWS2	intact:EBI-989293|uniprotkb:Q8C3G4|uniprotkb:Q8C7H0|ensembl:ENSMUSP00000069549	psi-mi:rnd3_mouse(display_long)|uniprotkb:Rnd3(gene name)|psi-mi:Rnd3(display_short)|uniprotkb:Arhe(gene name synonym)|uniprotkb:Rhoe(gene name synonym)|uniprotkb:Rho family GTPase 3(gene name synonym)|uniprotkb:Rnd3(gene name synonym)	psi-mi:rock1_mouse(display_long)|uniprotkb:Rho-associated, coiled-coil-containing protein kinase 1(gene name synonym)|uniprotkb:p160 ROCK-1(gene name synonym)|uniprotkb:Rock1(gene name)|psi-mi:Rock1(display_short)|uniprotkb:Rho-associated, coiled-coil-containing protein kinase I(gene name synonym)	psi-mi:"MI:0096"(pull down)	Komander et al. (2008)	pubmed:18946488|imex:IM-13799|mint:MINT-7293468|doi:10.1038/emboj.2008.226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8454560|mint:MINT-7293596|imex:IM-13799-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000017144(gene)|ensembl:ENSMUST00000017288(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0007015"(actin filament organization)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016477"(cell migration)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030865"(cortical cytoskeleton organization)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0042995"(cell projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR041843|mint:P61588|rcsb pdb:1GWN|reactome:R-MMU-9696264|refseq:NP_083086.1|mint:MINT-7293604(identity)	go:"GO:0007159"(leukocyte cell-cell adhesion)|ensembl:ENSMUSG00000024290(gene)|ensembl:ENSMUST00000067947(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001726"(ruffle)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0003383"(apical constriction)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005814"(centriole)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0072518"(Rho-dependent protein serine/threonine kinase activity)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090521"(glomerular visceral epithelial cell migration)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0110061"(regulation of angiotensin-activated signaling pathway)|go:"GO:0140058"(neuron projection arborization)|go:"GO:1900223"(positive regulation of amyloid-beta clearance)|go:"GO:1900242"(regulation of synaptic vesicle endocytosis)|go:"GO:1901888"(regulation of cell junction assembly)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902992"(negative regulation of amyloid precursor protein catabolic process)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:1905205"(positive regulation of connective tissue replacement)|go:"GO:1990776"(response to angiotensin)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|go:"GO:0071559"(response to transforming growth factor beta)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR015008(Rho Binding)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020684|interpro:IPR037310|mint:P70335|reactome:R-MMU-111465|reactome:R-MMU-3928662|reactome:R-MMU-416482|reactome:R-MMU-416572|reactome:R-MMU-4420097|reactome:R-MMU-5627117|reactome:R-MMU-6798695|reactome:R-MMU-8980692|reactome:R-MMU-9013026|reactome:R-MMU-9013106|reactome:R-MMU-9013407|reactome:R-MMU-9013422|reactome:R-MMU-9696264|interpro:IPR011072(HR1 rho-binding repeat)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019828"(aspartic-type endopeptidase inhibitor activity)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0031175"(neuron projection development)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032059"(bleb)|go:"GO:0032060"(bleb assembly)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032970"(regulation of actin filament-based process)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0042326"(negative regulation of phosphorylation)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045616"(regulation of keratinocyte differentiation)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048598"(embryonic morphogenesis)|go:"GO:0050900"(leukocyte migration)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0051451"(myoblast migration)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0061157"(mRNA destabilization)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|refseq:NP_033097.1|refseq:XP_006525788.1|dip:DIP-35521N|mint:MINT-7293598(identity)	-	-	-	comment:homomint|comment:mint|comment:ROCK1 protein taxid has not been specified|figure legend:F6A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/10/19	2014/10/16	rogid:nRE3V8nu01Om6bk+I97m3IubAJg10090	rogid:BIAb7c+Ar8WI6cES/igerUjk1zc10090	intact-crc:3D6E3F2B157AA84A|rigid:4JO3olvTN8DRSBoDECHwTfn6++A	false	glutathione s tranferase tag:?-?(MINT-7293605)|mutation disrupting interaction:192-192(MINT-7293607)	myc tag:?-?(MINT-7293601)|binding-associated region:1-420(MINT-7293599)	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P61588	uniprotkb:P70335	intact:EBI-6930266|ensembl:ENSMUSP00000017288|uniprotkb:P52199|uniprotkb:Q6ZWS2	intact:EBI-989293|uniprotkb:Q8C3G4|uniprotkb:Q8C7H0|ensembl:ENSMUSP00000069549	psi-mi:rnd3_mouse(display_long)|uniprotkb:Rnd3(gene name)|psi-mi:Rnd3(display_short)|uniprotkb:Arhe(gene name synonym)|uniprotkb:Rhoe(gene name synonym)|uniprotkb:Rho family GTPase 3(gene name synonym)|uniprotkb:Rnd3(gene name synonym)	psi-mi:rock1_mouse(display_long)|uniprotkb:Rho-associated, coiled-coil-containing protein kinase 1(gene name synonym)|uniprotkb:p160 ROCK-1(gene name synonym)|uniprotkb:Rock1(gene name)|psi-mi:Rock1(display_short)|uniprotkb:Rho-associated, coiled-coil-containing protein kinase I(gene name synonym)	psi-mi:"MI:0096"(pull down)	Komander et al. (2008)	pubmed:18946488|imex:IM-13799|mint:MINT-7293468|doi:10.1038/emboj.2008.226	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8454517|mint:MINT-7293578|imex:IM-13799-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000017144(gene)|ensembl:ENSMUST00000017288(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0007015"(actin filament organization)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016477"(cell migration)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030865"(cortical cytoskeleton organization)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0042995"(cell projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR041843|mint:P61588|rcsb pdb:1GWN|reactome:R-MMU-9696264|refseq:NP_083086.1|mint:MINT-7293580(identity)	go:"GO:0007159"(leukocyte cell-cell adhesion)|ensembl:ENSMUSG00000024290(gene)|ensembl:ENSMUST00000067947(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001726"(ruffle)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0003383"(apical constriction)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005814"(centriole)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0072518"(Rho-dependent protein serine/threonine kinase activity)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090521"(glomerular visceral epithelial cell migration)|go:"GO:0097746"(blood vessel diameter maintenance)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0110061"(regulation of angiotensin-activated signaling pathway)|go:"GO:0140058"(neuron projection arborization)|go:"GO:1900223"(positive regulation of amyloid-beta clearance)|go:"GO:1900242"(regulation of synaptic vesicle endocytosis)|go:"GO:1901888"(regulation of cell junction assembly)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1902992"(negative regulation of amyloid precursor protein catabolic process)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:1905205"(positive regulation of connective tissue replacement)|go:"GO:1990776"(response to angiotensin)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|go:"GO:0071559"(response to transforming growth factor beta)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR015008(Rho Binding)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020684|interpro:IPR037310|mint:P70335|reactome:R-MMU-111465|reactome:R-MMU-3928662|reactome:R-MMU-416482|reactome:R-MMU-416572|reactome:R-MMU-4420097|reactome:R-MMU-5627117|reactome:R-MMU-6798695|reactome:R-MMU-8980692|reactome:R-MMU-9013026|reactome:R-MMU-9013106|reactome:R-MMU-9013407|reactome:R-MMU-9013422|reactome:R-MMU-9696264|interpro:IPR011072(HR1 rho-binding repeat)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019828"(aspartic-type endopeptidase inhibitor activity)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0031175"(neuron projection development)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032059"(bleb)|go:"GO:0032060"(bleb assembly)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032970"(regulation of actin filament-based process)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0042326"(negative regulation of phosphorylation)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0045616"(regulation of keratinocyte differentiation)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048598"(embryonic morphogenesis)|go:"GO:0050900"(leukocyte migration)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0051451"(myoblast migration)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0061157"(mRNA destabilization)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|refseq:NP_033097.1|refseq:XP_006525788.1|dip:DIP-35521N|mint:MINT-7293588(identity)	-	-	-	comment:homomint|comment:mint|comment:ROCK1 protein taxid has not been specified|figure legend:F6A|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/10/19	2014/10/16	rogid:nRE3V8nu01Om6bk+I97m3IubAJg10090	rogid:BIAb7c+Ar8WI6cES/igerUjk1zc10090	intact-crc:EEF02EFCE357B251|rigid:4JO3olvTN8DRSBoDECHwTfn6++A	false	glutathione s tranferase tag:?-?(MINT-7293583)|mutation disrupting interaction:173-173(MINT-7293581)	myc tag:?-?(MINT-7293589)|binding-associated region:1-420(MINT-7293591)	-	-	psi-mi:"MI:0818"(molecular weight estimation by coomasie staining)	psi-mi:"MI:0705"(anti tag western blot)