#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q12913 uniprotkb:P35968 intact:EBI-2264500|uniprotkb:Q9UDA9|uniprotkb:Q15255|uniprotkb:Q8NHM2|uniprotkb:Q6P4H4|ensembl:ENSP00000400010 intact:EBI-1005487|intact:EBI-28976571|ensembl:ENSP00000263923|uniprotkb:O60723|uniprotkb:Q14178|uniprotkb:A2RRS0|uniprotkb:B5A925|uniprotkb:C5IFA0 psi-mi:ptprj_human(display_long)|uniprotkb:PTPRJ(gene name)|psi-mi:PTPRJ(display_short)|uniprotkb:DEP1(gene name synonym)|uniprotkb:HPTP eta(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase receptor type J(gene name synonym)|uniprotkb:Density-enhanced phosphatase 1(gene name synonym) psi-mi:vgfr2_human(display_long)|uniprotkb:Kinase insert domain receptor(gene name synonym)|uniprotkb:Protein-tyrosine kinase receptor flk-1(gene name synonym)|uniprotkb:KDR(gene name)|psi-mi:KDR(display_short)|uniprotkb:FLK1(gene name synonym)|uniprotkb:Fetal liver kinase 1(gene name synonym)|uniprotkb:VEGFR2(gene name synonym) psi-mi:"MI:0401"(biochemical) Chabot et al. (2009) pubmed:18936167|mint:MINT-7027110|doi:10.1128/MCB.01374-08 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0203"(dephosphorylation reaction) psi-mi:"MI:0471"(MINT) intact:EBI-8452980|mint:MINT-7027117 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002834.3|refseq:NP_001091973.1|go:"GO:0070097"(delta-catenin binding)|go:"GO:1905451"(positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|interpro:IPR036116|interpro:IPR041201|mint:Q12913|rcsb pdb:2CFV|rcsb pdb:2DLE|rcsb pdb:2NZ6|reactome:R-HSA-202427|reactome:R-HSA-6798695|reactome:R-HSA-6807004|ensembl:ENSG00000149177(gene)|ensembl:ENST00000418331(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0043116"(negative regulation of vascular permeability)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0050918"(positive chemotaxis)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0060242"(contact inhibition)|go:"GO:0070062"(extracellular exosome)|go:"GO:0035579"(specific granule membrane)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010642"(negative regulation of platelet-derived growth factor receptor signaling pathway)|go:"GO:0016791"(phosphatase activity)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0006470"(protein dephosphorylation)|reactome:R-HSA-9706369|mint:MINT-7027122(identity)|uniprotkb:Q12913(Q12913) refseq:NP_002244.1|ensembl:ENSP00000263923|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016477"(cell migration)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019838"(growth factor binding)|go:"GO:0030054"(cell junction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0036324"(vascular endothelial growth factor receptor-2 signaling pathway)|go:"GO:0038033"(positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0038084"(vascular endothelial growth factor signaling pathway)|go:"GO:0038085"(vascular endothelial growth factor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045121"(membrane raft)|go:"GO:0045296"(cadherin binding)|go:"GO:0045446"(endothelial cell differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0050927"(positive regulation of positive chemotaxis)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0051901"(positive regulation of mitochondrial depolarization)|go:"GO:0061042"(vascular wound healing)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0097443"(sorting endosome)|go:"GO:1904881"(cellular response to hydrogen sulfide)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|go:"GO:2001214"(positive regulation of vasculogenesis)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001824(Receptor tyrosine kinase, class III, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009136(Vascular endothelial growth factor receptor 2, VEGFR2)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR036179|interpro:IPR041348|go:"GO:0090050"(positive regulation of cell migration involved in sprouting angiogenesis)|mint:P35968|rcsb pdb:1VR2|rcsb pdb:1Y6A|rcsb pdb:1Y6B|rcsb pdb:1YWN|rcsb pdb:2M59|rcsb pdb:2MET|rcsb pdb:2MEU|rcsb pdb:2OH4|rcsb pdb:2P2H|rcsb pdb:2P2I|rcsb pdb:2QU5|rcsb pdb:2QU6|rcsb pdb:2RL5|rcsb pdb:2X1W|rcsb pdb:2X1X|rcsb pdb:2XIR|rcsb pdb:3B8Q|rcsb pdb:3B8R|rcsb pdb:3BE2|rcsb pdb:3C7Q|rcsb pdb:3CJF|rcsb pdb:3CJG|rcsb pdb:3CP9|rcsb pdb:3CPB|rcsb pdb:3CPC|rcsb pdb:3DTW|rcsb pdb:3EFL|rcsb pdb:3EWH|rcsb pdb:3KVQ|rcsb pdb:3S35|rcsb pdb:3S36|rcsb pdb:3S37|rcsb pdb:3U6J|rcsb pdb:3V2A|rcsb pdb:3V6B|rcsb pdb:3VHE|rcsb pdb:3VHK|rcsb pdb:3VID|rcsb pdb:3VNT|rcsb pdb:3VO3|rcsb pdb:3WZD|rcsb pdb:3WZE|rcsb pdb:4AG8|rcsb pdb:4AGC|rcsb pdb:4AGD|rcsb pdb:4ASD|rcsb pdb:4ASE|rcsb pdb:5EW3|rcsb pdb:5OYJ|rcsb pdb:6GQO|rcsb pdb:6GQP|rcsb pdb:6GQQ|rcsb pdb:6XVJ|rcsb pdb:6XVK|reactome:R-HSA-194306|reactome:R-HSA-195399|reactome:R-HSA-216083|reactome:R-HSA-4420097|reactome:R-HSA-5218921|reactome:R-HSA-9673768|ensembl:ENSG00000128052(gene)|ensembl:ENST00000263923(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0003158"(endothelium development)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005021"(vascular endothelial growth factor-activated receptor activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|dip:DIP-486N|mint:MINT-7027118(identity)|uniprotkb:P35968(P35968) - - - comment:homomint|comment:mint|figure legend:F2; F3|partial coverage:partial coverage|curation depth:rapid curation taxid:-3(unknown)|taxid:-3(Unknown) - 2009/04/10 2014/10/16 rogid:tGsQm2S/SSUjbnV/WwKSb4rPz/49606 rogid:NnrnIZM28U6DGKYiDT9+sh/fi8Y9606 intact-crc:4A3E0313F4C02005|rigid:+3AJ/115usbHZIj9eIPVFieVdPY false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P35968 uniprotkb:Q12913 intact:EBI-1005487|intact:EBI-28976571|ensembl:ENSP00000263923|uniprotkb:O60723|uniprotkb:Q14178|uniprotkb:A2RRS0|uniprotkb:B5A925|uniprotkb:C5IFA0 intact:EBI-2264500|uniprotkb:Q9UDA9|uniprotkb:Q15255|uniprotkb:Q8NHM2|uniprotkb:Q6P4H4|ensembl:ENSP00000400010 psi-mi:vgfr2_human(display_long)|uniprotkb:Kinase insert domain receptor(gene name synonym)|uniprotkb:Protein-tyrosine kinase receptor flk-1(gene name synonym)|uniprotkb:KDR(gene name)|psi-mi:KDR(display_short)|uniprotkb:FLK1(gene name synonym)|uniprotkb:Fetal liver kinase 1(gene name synonym)|uniprotkb:VEGFR2(gene name synonym) psi-mi:ptprj_human(display_long)|uniprotkb:PTPRJ(gene name)|psi-mi:PTPRJ(display_short)|uniprotkb:DEP1(gene name synonym)|uniprotkb:HPTP eta(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase receptor type J(gene name synonym)|uniprotkb:Density-enhanced phosphatase 1(gene name synonym) psi-mi:"MI:0019"(coimmunoprecipitation) Chabot et al. (2009) pubmed:18936167|mint:MINT-7027110|doi:10.1128/MCB.01374-08 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8453006|mint:MINT-7027129 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002244.1|ensembl:ENSP00000263923|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016477"(cell migration)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019838"(growth factor binding)|go:"GO:0030054"(cell junction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0036324"(vascular endothelial growth factor receptor-2 signaling pathway)|go:"GO:0038033"(positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0038084"(vascular endothelial growth factor signaling pathway)|go:"GO:0038085"(vascular endothelial growth factor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045121"(membrane raft)|go:"GO:0045296"(cadherin binding)|go:"GO:0045446"(endothelial cell differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0050927"(positive regulation of positive chemotaxis)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0051901"(positive regulation of mitochondrial depolarization)|go:"GO:0061042"(vascular wound healing)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0097443"(sorting endosome)|go:"GO:1904881"(cellular response to hydrogen sulfide)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|go:"GO:2001214"(positive regulation of vasculogenesis)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001824(Receptor tyrosine kinase, class III, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009136(Vascular endothelial growth factor receptor 2, VEGFR2)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR036179|interpro:IPR041348|go:"GO:0090050"(positive regulation of cell migration involved in sprouting angiogenesis)|mint:P35968|rcsb pdb:1VR2|rcsb pdb:1Y6A|rcsb pdb:1Y6B|rcsb pdb:1YWN|rcsb pdb:2M59|rcsb pdb:2MET|rcsb pdb:2MEU|rcsb pdb:2OH4|rcsb pdb:2P2H|rcsb pdb:2P2I|rcsb pdb:2QU5|rcsb pdb:2QU6|rcsb pdb:2RL5|rcsb pdb:2X1W|rcsb pdb:2X1X|rcsb pdb:2XIR|rcsb pdb:3B8Q|rcsb pdb:3B8R|rcsb pdb:3BE2|rcsb pdb:3C7Q|rcsb pdb:3CJF|rcsb pdb:3CJG|rcsb pdb:3CP9|rcsb pdb:3CPB|rcsb pdb:3CPC|rcsb pdb:3DTW|rcsb pdb:3EFL|rcsb pdb:3EWH|rcsb pdb:3KVQ|rcsb pdb:3S35|rcsb pdb:3S36|rcsb pdb:3S37|rcsb pdb:3U6J|rcsb pdb:3V2A|rcsb pdb:3V6B|rcsb pdb:3VHE|rcsb pdb:3VHK|rcsb pdb:3VID|rcsb pdb:3VNT|rcsb pdb:3VO3|rcsb pdb:3WZD|rcsb pdb:3WZE|rcsb pdb:4AG8|rcsb pdb:4AGC|rcsb pdb:4AGD|rcsb pdb:4ASD|rcsb pdb:4ASE|rcsb pdb:5EW3|rcsb pdb:5OYJ|rcsb pdb:6GQO|rcsb pdb:6GQP|rcsb pdb:6GQQ|rcsb pdb:6XVJ|rcsb pdb:6XVK|reactome:R-HSA-194306|reactome:R-HSA-195399|reactome:R-HSA-216083|reactome:R-HSA-4420097|reactome:R-HSA-5218921|reactome:R-HSA-9673768|ensembl:ENSG00000128052(gene)|ensembl:ENST00000263923(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0003158"(endothelium development)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005021"(vascular endothelial growth factor-activated receptor activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|dip:DIP-486N|mint:MINT-7027134(identity)|uniprotkb:P35968(P35968) refseq:NP_002834.3|refseq:NP_001091973.1|go:"GO:0070097"(delta-catenin binding)|go:"GO:1905451"(positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|interpro:IPR036116|interpro:IPR041201|mint:Q12913|rcsb pdb:2CFV|rcsb pdb:2DLE|rcsb pdb:2NZ6|reactome:R-HSA-202427|reactome:R-HSA-6798695|reactome:R-HSA-6807004|ensembl:ENSG00000149177(gene)|ensembl:ENST00000418331(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0043116"(negative regulation of vascular permeability)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0050918"(positive chemotaxis)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0060242"(contact inhibition)|go:"GO:0070062"(extracellular exosome)|go:"GO:0035579"(specific granule membrane)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010642"(negative regulation of platelet-derived growth factor receptor signaling pathway)|go:"GO:0016791"(phosphatase activity)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0006470"(protein dephosphorylation)|reactome:R-HSA-9706369|mint:MINT-7027130(identity)|uniprotkb:Q12913(Q12913) - - - figure legend:F1|comment:homomint|comment:mint|partial coverage:partial coverage|curation depth:rapid curation taxid:-3(unknown)|taxid:-3(Unknown) - 2009/04/10 2014/10/16 rogid:NnrnIZM28U6DGKYiDT9+sh/fi8Y9606 rogid:tGsQm2S/SSUjbnV/WwKSb4rPz/49606 intact-crc:7722AA85B60A4525|rigid:+3AJ/115usbHZIj9eIPVFieVdPY false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q12913 uniprotkb:P35968 intact:EBI-2264500|uniprotkb:Q9UDA9|uniprotkb:Q15255|uniprotkb:Q8NHM2|uniprotkb:Q6P4H4|ensembl:ENSP00000400010 intact:EBI-1005487|intact:EBI-28976571|ensembl:ENSP00000263923|uniprotkb:O60723|uniprotkb:Q14178|uniprotkb:A2RRS0|uniprotkb:B5A925|uniprotkb:C5IFA0 psi-mi:ptprj_human(display_long)|uniprotkb:PTPRJ(gene name)|psi-mi:PTPRJ(display_short)|uniprotkb:DEP1(gene name synonym)|uniprotkb:HPTP eta(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase receptor type J(gene name synonym)|uniprotkb:Density-enhanced phosphatase 1(gene name synonym) psi-mi:vgfr2_human(display_long)|uniprotkb:Kinase insert domain receptor(gene name synonym)|uniprotkb:Protein-tyrosine kinase receptor flk-1(gene name synonym)|uniprotkb:KDR(gene name)|psi-mi:KDR(display_short)|uniprotkb:FLK1(gene name synonym)|uniprotkb:Fetal liver kinase 1(gene name synonym)|uniprotkb:VEGFR2(gene name synonym) psi-mi:"MI:0434"(phosphatase assay) Chabot et al. (2009) pubmed:18936167|mint:MINT-7027110|doi:10.1128/MCB.01374-08 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0203"(dephosphorylation reaction) psi-mi:"MI:0471"(MINT) intact:EBI-8453050|mint:MINT-7027141 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002834.3|refseq:NP_001091973.1|go:"GO:0070097"(delta-catenin binding)|go:"GO:1905451"(positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|interpro:IPR036116|interpro:IPR041201|mint:Q12913|rcsb pdb:2CFV|rcsb pdb:2DLE|rcsb pdb:2NZ6|reactome:R-HSA-202427|reactome:R-HSA-6798695|reactome:R-HSA-6807004|ensembl:ENSG00000149177(gene)|ensembl:ENST00000418331(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0043116"(negative regulation of vascular permeability)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0050918"(positive chemotaxis)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0060242"(contact inhibition)|go:"GO:0070062"(extracellular exosome)|go:"GO:0035579"(specific granule membrane)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010642"(negative regulation of platelet-derived growth factor receptor signaling pathway)|go:"GO:0016791"(phosphatase activity)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0006470"(protein dephosphorylation)|reactome:R-HSA-9706369|mint:MINT-7027142(identity)|uniprotkb:Q12913(Q12913) refseq:NP_002244.1|ensembl:ENSP00000263923|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016477"(cell migration)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019838"(growth factor binding)|go:"GO:0030054"(cell junction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0036324"(vascular endothelial growth factor receptor-2 signaling pathway)|go:"GO:0038033"(positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0038084"(vascular endothelial growth factor signaling pathway)|go:"GO:0038085"(vascular endothelial growth factor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045121"(membrane raft)|go:"GO:0045296"(cadherin binding)|go:"GO:0045446"(endothelial cell differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0050927"(positive regulation of positive chemotaxis)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0051901"(positive regulation of mitochondrial depolarization)|go:"GO:0061042"(vascular wound healing)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0097443"(sorting endosome)|go:"GO:1904881"(cellular response to hydrogen sulfide)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|go:"GO:2001214"(positive regulation of vasculogenesis)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001824(Receptor tyrosine kinase, class III, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009136(Vascular endothelial growth factor receptor 2, VEGFR2)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR036179|interpro:IPR041348|go:"GO:0090050"(positive regulation of cell migration involved in sprouting angiogenesis)|mint:P35968|rcsb pdb:1VR2|rcsb pdb:1Y6A|rcsb pdb:1Y6B|rcsb pdb:1YWN|rcsb pdb:2M59|rcsb pdb:2MET|rcsb pdb:2MEU|rcsb pdb:2OH4|rcsb pdb:2P2H|rcsb pdb:2P2I|rcsb pdb:2QU5|rcsb pdb:2QU6|rcsb pdb:2RL5|rcsb pdb:2X1W|rcsb pdb:2X1X|rcsb pdb:2XIR|rcsb pdb:3B8Q|rcsb pdb:3B8R|rcsb pdb:3BE2|rcsb pdb:3C7Q|rcsb pdb:3CJF|rcsb pdb:3CJG|rcsb pdb:3CP9|rcsb pdb:3CPB|rcsb pdb:3CPC|rcsb pdb:3DTW|rcsb pdb:3EFL|rcsb pdb:3EWH|rcsb pdb:3KVQ|rcsb pdb:3S35|rcsb pdb:3S36|rcsb pdb:3S37|rcsb pdb:3U6J|rcsb pdb:3V2A|rcsb pdb:3V6B|rcsb pdb:3VHE|rcsb pdb:3VHK|rcsb pdb:3VID|rcsb pdb:3VNT|rcsb pdb:3VO3|rcsb pdb:3WZD|rcsb pdb:3WZE|rcsb pdb:4AG8|rcsb pdb:4AGC|rcsb pdb:4AGD|rcsb pdb:4ASD|rcsb pdb:4ASE|rcsb pdb:5EW3|rcsb pdb:5OYJ|rcsb pdb:6GQO|rcsb pdb:6GQP|rcsb pdb:6GQQ|rcsb pdb:6XVJ|rcsb pdb:6XVK|reactome:R-HSA-194306|reactome:R-HSA-195399|reactome:R-HSA-216083|reactome:R-HSA-4420097|reactome:R-HSA-5218921|reactome:R-HSA-9673768|ensembl:ENSG00000128052(gene)|ensembl:ENST00000263923(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0003158"(endothelium development)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005021"(vascular endothelial growth factor-activated receptor activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|dip:DIP-486N|mint:MINT-7027146(identity)|uniprotkb:P35968(P35968) - - - figure legend:F1|comment:homomint|comment:mint|partial coverage:partial coverage|curation depth:rapid curation taxid:-3(unknown)|taxid:-3(Unknown) - 2009/04/10 2014/10/16 rogid:tGsQm2S/SSUjbnV/WwKSb4rPz/49606 rogid:NnrnIZM28U6DGKYiDT9+sh/fi8Y9606 intact-crc:2EF28AB56DBAB24D|rigid:+3AJ/115usbHZIj9eIPVFieVdPY false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P35968 uniprotkb:Q12913 intact:EBI-1005487|intact:EBI-28976571|ensembl:ENSP00000263923|uniprotkb:O60723|uniprotkb:Q14178|uniprotkb:A2RRS0|uniprotkb:B5A925|uniprotkb:C5IFA0 intact:EBI-2264500|uniprotkb:Q9UDA9|uniprotkb:Q15255|uniprotkb:Q8NHM2|uniprotkb:Q6P4H4|ensembl:ENSP00000400010 psi-mi:vgfr2_human(display_long)|uniprotkb:Kinase insert domain receptor(gene name synonym)|uniprotkb:Protein-tyrosine kinase receptor flk-1(gene name synonym)|uniprotkb:KDR(gene name)|psi-mi:KDR(display_short)|uniprotkb:FLK1(gene name synonym)|uniprotkb:Fetal liver kinase 1(gene name synonym)|uniprotkb:VEGFR2(gene name synonym) psi-mi:ptprj_human(display_long)|uniprotkb:PTPRJ(gene name)|psi-mi:PTPRJ(display_short)|uniprotkb:DEP1(gene name synonym)|uniprotkb:HPTP eta(gene name synonym)|uniprotkb:Protein-tyrosine phosphatase receptor type J(gene name synonym)|uniprotkb:Density-enhanced phosphatase 1(gene name synonym) psi-mi:"MI:0096"(pull down) Chabot et al. (2009) pubmed:18936167|mint:MINT-7027110|doi:10.1128/MCB.01374-08 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8453076|mint:MINT-7027153 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_002244.1|ensembl:ENSP00000263923|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0016477"(cell migration)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019838"(growth factor binding)|go:"GO:0030054"(cell junction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0033674"(positive regulation of kinase activity)|go:"GO:0035162"(embryonic hemopoiesis)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0036324"(vascular endothelial growth factor receptor-2 signaling pathway)|go:"GO:0038033"(positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0038084"(vascular endothelial growth factor signaling pathway)|go:"GO:0038085"(vascular endothelial growth factor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045121"(membrane raft)|go:"GO:0045296"(cadherin binding)|go:"GO:0045446"(endothelial cell differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0050927"(positive regulation of positive chemotaxis)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0051901"(positive regulation of mitochondrial depolarization)|go:"GO:0061042"(vascular wound healing)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0090141"(positive regulation of mitochondrial fission)|go:"GO:0097443"(sorting endosome)|go:"GO:1904881"(cellular response to hydrogen sulfide)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|go:"GO:2001214"(positive regulation of vasculogenesis)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001824(Receptor tyrosine kinase, class III, conserved site)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR009136(Vascular endothelial growth factor receptor 2, VEGFR2)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013151(Immunoglobulin)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR036179|interpro:IPR041348|go:"GO:0090050"(positive regulation of cell migration involved in sprouting angiogenesis)|mint:P35968|rcsb pdb:1VR2|rcsb pdb:1Y6A|rcsb pdb:1Y6B|rcsb pdb:1YWN|rcsb pdb:2M59|rcsb pdb:2MET|rcsb pdb:2MEU|rcsb pdb:2OH4|rcsb pdb:2P2H|rcsb pdb:2P2I|rcsb pdb:2QU5|rcsb pdb:2QU6|rcsb pdb:2RL5|rcsb pdb:2X1W|rcsb pdb:2X1X|rcsb pdb:2XIR|rcsb pdb:3B8Q|rcsb pdb:3B8R|rcsb pdb:3BE2|rcsb pdb:3C7Q|rcsb pdb:3CJF|rcsb pdb:3CJG|rcsb pdb:3CP9|rcsb pdb:3CPB|rcsb pdb:3CPC|rcsb pdb:3DTW|rcsb pdb:3EFL|rcsb pdb:3EWH|rcsb pdb:3KVQ|rcsb pdb:3S35|rcsb pdb:3S36|rcsb pdb:3S37|rcsb pdb:3U6J|rcsb pdb:3V2A|rcsb pdb:3V6B|rcsb pdb:3VHE|rcsb pdb:3VHK|rcsb pdb:3VID|rcsb pdb:3VNT|rcsb pdb:3VO3|rcsb pdb:3WZD|rcsb pdb:3WZE|rcsb pdb:4AG8|rcsb pdb:4AGC|rcsb pdb:4AGD|rcsb pdb:4ASD|rcsb pdb:4ASE|rcsb pdb:5EW3|rcsb pdb:5OYJ|rcsb pdb:6GQO|rcsb pdb:6GQP|rcsb pdb:6GQQ|rcsb pdb:6XVJ|rcsb pdb:6XVK|reactome:R-HSA-194306|reactome:R-HSA-195399|reactome:R-HSA-216083|reactome:R-HSA-4420097|reactome:R-HSA-5218921|reactome:R-HSA-9673768|ensembl:ENSG00000128052(gene)|ensembl:ENST00000263923(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0003158"(endothelium development)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005021"(vascular endothelial growth factor-activated receptor activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|dip:DIP-486N|mint:MINT-7027154(identity)|uniprotkb:P35968(P35968) refseq:NP_002834.3|refseq:NP_001091973.1|go:"GO:0070097"(delta-catenin binding)|go:"GO:1905451"(positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|interpro:IPR036116|interpro:IPR041201|mint:Q12913|rcsb pdb:2CFV|rcsb pdb:2DLE|rcsb pdb:2NZ6|reactome:R-HSA-202427|reactome:R-HSA-6798695|reactome:R-HSA-6807004|ensembl:ENSG00000149177(gene)|ensembl:ENST00000418331(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0043116"(negative regulation of vascular permeability)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0050918"(positive chemotaxis)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0060242"(contact inhibition)|go:"GO:0070062"(extracellular exosome)|go:"GO:0035579"(specific granule membrane)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0010642"(negative regulation of platelet-derived growth factor receptor signaling pathway)|go:"GO:0016791"(phosphatase activity)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0006470"(protein dephosphorylation)|reactome:R-HSA-9706369|mint:MINT-7027158(identity)|uniprotkb:Q12913(Q12913) - - - figure legend:F1|comment:homomint|comment:mint|partial coverage:partial coverage|curation depth:rapid curation taxid:-3(unknown)|taxid:-3(Unknown) - 2009/04/10 2014/10/16 rogid:NnrnIZM28U6DGKYiDT9+sh/fi8Y9606 rogid:tGsQm2S/SSUjbnV/WwKSb4rPz/49606 intact-crc:5AD070260B4D4983|rigid:+3AJ/115usbHZIj9eIPVFieVdPY false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)