#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:B1WCA1 uniprotkb:P61810 intact:EBI-8078743|intact:MINT-7304222|ensembl:ENSRNOP00000005624 intact:EBI-2008489|uniprotkb:Q62938|ensembl:ENSRNOP00000062473 psi-mi:b1wca1_rat(display_long)|uniprotkb:Fzr1(gene name)|psi-mi:Fzr1(display_short)|uniprotkb:Fzr1_predicted(gene name synonym)|uniprotkb:rCG_29304(orf name) psi-mi:cd5r1_rat(display_long)|uniprotkb:Cdk5r1(gene name)|psi-mi:Cdk5r1(display_short)|uniprotkb:Cdk5r(gene name synonym)|uniprotkb:Cyclin-dependent kinase 5 regulatory subunit 1(gene name synonym)|uniprotkb:TPKII regulatory subunit(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Maestre et al. (2008) pubmed:18818692|imex:IM-13583|mint:MINT-7304210|doi:10.1038/emboj.2008.195 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8078736|mint:MINT-7304239|imex:IM-13583-3 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rgd:1308713|refseq:NP_001101544.2|ensembl:ENSRNOG00000004169(gene)|ensembl:ENSRNOT00000005624(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005680"(anaphase-promoting complex)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010997"(anaphase-promoting complex binding)|go:"GO:0031145"(anaphase-promoting complex-dependent catabolic process)|go:"GO:0031965"(nuclear membrane)|go:"GO:0040020"(regulation of meiotic nuclear division)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0051301"(cell division)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0070306"(lens fiber cell differentiation)|go:"GO:0090344"(negative regulation of cell aging)|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|go:"GO:1905786"(positive regulation of anaphase-promoting complex-dependent catabolic process)|go:"GO:1990757"(ubiquitin ligase activator activity)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR024977|interpro:IPR033010|interpro:IPR036322|mint:B1WCA1|reactome:R-RNO-174084|reactome:R-RNO-174178|reactome:R-RNO-176407|reactome:R-RNO-176408|reactome:R-RNO-176417|reactome:R-RNO-2559582|reactome:R-RNO-69017|reactome:R-RNO-69656|reactome:R-RNO-983168|mint:MINT-7304242(identity) rgd:629472|refseq:NP_446343.1|dip:DIP-29352N|ensembl:ENSRNOG00000021685(gene)|ensembl:ENSRNOT00000031746(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0002020"(protease binding)|go:"GO:0003779"(actin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007158"(neuron cell-cell adhesion)|go:"GO:0007213"(G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007420"(brain development)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016533"(protein kinase 5 complex)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0021722"(superior olivary nucleus maturation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021799"(cerebral cortex radially oriented cell migration)|go:"GO:0021819"(layer formation in cerebral cortex)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030517"(negative regulation of axon extension)|go:"GO:0031175"(neuron projection development)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042501"(serine phosphorylation of STAT protein)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043292"(contractile fiber)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045296"(cadherin binding)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048511"(rhythmic process)|go:"GO:0048675"(axon extension)|go:"GO:0051015"(actin filament binding)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0061575"(cyclin-dependent protein serine/threonine kinase activator activity)|go:"GO:0070315"(G1 to G0 transition involved in cell differentiation)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0098693"(regulation of synaptic vesicle cycle)|go:"GO:0098793"(presynapse)|interpro:IPR004944(Cyclin-dependent kinase 5 activator)|interpro:IPR036915|mint:P61810|reactome:R-RNO-399956|reactome:R-RNO-6804756|mint:MINT-7304241(identity) - comment:mint - figure legend:F4D|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:10116(rat-neuron)|taxid:10116(Rattus norvegicus neuronal cell) - 2009/11/24 2014/10/16 rogid:9xA+kWdbAvllhtmfWO522fanHhs10116 rogid:VkEjZ4nsw2rhfNWK5hlbCUlmNw810116 intact-crc:2EA3807BF2D44175|rigid:YSXpn3HgU9xg5xXtLJdHnrLI0vs false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0113"(western blot) uniprotkb:B1WCA1 uniprotkb:P61810 intact:EBI-8078743|intact:MINT-7304222|ensembl:ENSRNOP00000005624 intact:EBI-2008489|uniprotkb:Q62938|ensembl:ENSRNOP00000062473 psi-mi:b1wca1_rat(display_long)|uniprotkb:Fzr1(gene name)|psi-mi:Fzr1(display_short)|uniprotkb:Fzr1_predicted(gene name synonym)|uniprotkb:rCG_29304(orf name) psi-mi:cd5r1_rat(display_long)|uniprotkb:Cdk5r1(gene name)|psi-mi:Cdk5r1(display_short)|uniprotkb:Cdk5r(gene name synonym)|uniprotkb:Cyclin-dependent kinase 5 regulatory subunit 1(gene name synonym)|uniprotkb:TPKII regulatory subunit(gene name synonym) psi-mi:"MI:0424"(protein kinase assay) Maestre et al. (2008) pubmed:18818692|imex:IM-13583|mint:MINT-7304210|doi:10.1038/emboj.2008.195 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0217"(phosphorylation reaction) psi-mi:"MI:0471"(MINT) intact:EBI-8078802|mint:MINT-7304250|imex:IM-13583-1 - - psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rgd:1308713|refseq:NP_001101544.2|ensembl:ENSRNOG00000004169(gene)|ensembl:ENSRNOT00000005624(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005680"(anaphase-promoting complex)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010997"(anaphase-promoting complex binding)|go:"GO:0031145"(anaphase-promoting complex-dependent catabolic process)|go:"GO:0031965"(nuclear membrane)|go:"GO:0040020"(regulation of meiotic nuclear division)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0051301"(cell division)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0070306"(lens fiber cell differentiation)|go:"GO:0090344"(negative regulation of cell aging)|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|go:"GO:1905786"(positive regulation of anaphase-promoting complex-dependent catabolic process)|go:"GO:1990757"(ubiquitin ligase activator activity)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR024977|interpro:IPR033010|interpro:IPR036322|mint:B1WCA1|reactome:R-RNO-174084|reactome:R-RNO-174178|reactome:R-RNO-176407|reactome:R-RNO-176408|reactome:R-RNO-176417|reactome:R-RNO-2559582|reactome:R-RNO-69017|reactome:R-RNO-69656|reactome:R-RNO-983168|mint:MINT-7304252(identity) rgd:629472|refseq:NP_446343.1|dip:DIP-29352N|ensembl:ENSRNOG00000021685(gene)|ensembl:ENSRNOT00000031746(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0002020"(protease binding)|go:"GO:0003779"(actin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007158"(neuron cell-cell adhesion)|go:"GO:0007213"(G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007420"(brain development)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016533"(protein kinase 5 complex)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0021722"(superior olivary nucleus maturation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021799"(cerebral cortex radially oriented cell migration)|go:"GO:0021819"(layer formation in cerebral cortex)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030517"(negative regulation of axon extension)|go:"GO:0031175"(neuron projection development)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042501"(serine phosphorylation of STAT protein)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043292"(contractile fiber)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045296"(cadherin binding)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048511"(rhythmic process)|go:"GO:0048675"(axon extension)|go:"GO:0051015"(actin filament binding)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0061575"(cyclin-dependent protein serine/threonine kinase activator activity)|go:"GO:0070315"(G1 to G0 transition involved in cell differentiation)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0098693"(regulation of synaptic vesicle cycle)|go:"GO:0098793"(presynapse)|interpro:IPR004944(Cyclin-dependent kinase 5 activator)|interpro:IPR036915|mint:P61810|reactome:R-RNO-399956|reactome:R-RNO-6804756|mint:MINT-7304254(identity) - comment:mint - figure legend:F4A|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2009/11/24 2014/10/16 rogid:9xA+kWdbAvllhtmfWO522fanHhs10116 rogid:VkEjZ4nsw2rhfNWK5hlbCUlmNw810116 intact-crc:34E8F20AEF4B6EAF|rigid:YSXpn3HgU9xg5xXtLJdHnrLI0vs false - binding-associated region:1-307(MINT-7304258) - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0396"(predetermined participant) uniprotkb:B1WCA1 uniprotkb:P61810 intact:EBI-8078743|intact:MINT-7304222|ensembl:ENSRNOP00000005624 intact:EBI-2008489|uniprotkb:Q62938|ensembl:ENSRNOP00000062473 psi-mi:b1wca1_rat(display_long)|uniprotkb:Fzr1(gene name)|psi-mi:Fzr1(display_short)|uniprotkb:Fzr1_predicted(gene name synonym)|uniprotkb:rCG_29304(orf name) psi-mi:cd5r1_rat(display_long)|uniprotkb:Cdk5r1(gene name)|psi-mi:Cdk5r1(display_short)|uniprotkb:Cdk5r(gene name synonym)|uniprotkb:Cyclin-dependent kinase 5 regulatory subunit 1(gene name synonym)|uniprotkb:TPKII regulatory subunit(gene name synonym) psi-mi:"MI:0424"(protein kinase assay) Maestre et al. (2008) pubmed:18818692|imex:IM-13583|mint:MINT-7304210|doi:10.1038/emboj.2008.195 taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)") psi-mi:"MI:0217"(phosphorylation reaction) psi-mi:"MI:0471"(MINT) intact:EBI-8078817|mint:MINT-7304262|imex:IM-13583-2 - - psi-mi:"MI:0502"(enzyme target) psi-mi:"MI:0501"(enzyme) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) rgd:1308713|refseq:NP_001101544.2|ensembl:ENSRNOG00000004169(gene)|ensembl:ENSRNOT00000005624(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005680"(anaphase-promoting complex)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010997"(anaphase-promoting complex binding)|go:"GO:0031145"(anaphase-promoting complex-dependent catabolic process)|go:"GO:0031965"(nuclear membrane)|go:"GO:0040020"(regulation of meiotic nuclear division)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0051301"(cell division)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0070306"(lens fiber cell differentiation)|go:"GO:0090344"(negative regulation of cell aging)|go:"GO:1904668"(positive regulation of ubiquitin protein ligase activity)|go:"GO:1905786"(positive regulation of anaphase-promoting complex-dependent catabolic process)|go:"GO:1990757"(ubiquitin ligase activator activity)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR024977|interpro:IPR033010|interpro:IPR036322|mint:B1WCA1|reactome:R-RNO-174084|reactome:R-RNO-174178|reactome:R-RNO-176407|reactome:R-RNO-176408|reactome:R-RNO-176417|reactome:R-RNO-2559582|reactome:R-RNO-69017|reactome:R-RNO-69656|reactome:R-RNO-983168|mint:MINT-7304264(identity) rgd:629472|refseq:NP_446343.1|dip:DIP-29352N|ensembl:ENSRNOG00000021685(gene)|ensembl:ENSRNOT00000031746(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0002020"(protease binding)|go:"GO:0003779"(actin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007158"(neuron cell-cell adhesion)|go:"GO:0007213"(G protein-coupled acetylcholine receptor signaling pathway)|go:"GO:0007411"(axon guidance)|go:"GO:0007413"(axonal fasciculation)|go:"GO:0007420"(brain development)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016533"(protein kinase 5 complex)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0021722"(superior olivary nucleus maturation)|go:"GO:0021766"(hippocampus development)|go:"GO:0021799"(cerebral cortex radially oriented cell migration)|go:"GO:0021819"(layer formation in cerebral cortex)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0030517"(negative regulation of axon extension)|go:"GO:0031175"(neuron projection development)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0035235"(ionotropic glutamate receptor signaling pathway)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0042501"(serine phosphorylation of STAT protein)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043292"(contractile fiber)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045296"(cadherin binding)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048511"(rhythmic process)|go:"GO:0048675"(axon extension)|go:"GO:0051015"(actin filament binding)|go:"GO:0061001"(regulation of dendritic spine morphogenesis)|go:"GO:0061575"(cyclin-dependent protein serine/threonine kinase activator activity)|go:"GO:0070315"(G1 to G0 transition involved in cell differentiation)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0098693"(regulation of synaptic vesicle cycle)|go:"GO:0098793"(presynapse)|interpro:IPR004944(Cyclin-dependent kinase 5 activator)|interpro:IPR036915|mint:P61810|reactome:R-RNO-399956|reactome:R-RNO-6804756|mint:MINT-7304266(identity) - comment:mint - figure legend:F4A|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2009/11/24 2014/10/16 rogid:9xA+kWdbAvllhtmfWO522fanHhs10116 rogid:VkEjZ4nsw2rhfNWK5hlbCUlmNw810116 intact-crc:5AF1424DE03BAFF3|rigid:YSXpn3HgU9xg5xXtLJdHnrLI0vs false - binding-associated region:99-307(MINT-7304267) - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0396"(predetermined participant)