#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P70039 uniprotkb:O35625 intact:EBI-8069633|uniprotkb:P79934|intact:MINT-7305229 intact:EBI-2365912 psi-mi:apc_xenla(display_long)|uniprotkb:apc(gene name)|psi-mi:apc(display_short) psi-mi:axin1_mouse(display_long)|uniprotkb:Axin1(gene name)|psi-mi:Axin1(display_short)|uniprotkb:Axin(gene name synonym)|uniprotkb:Fu(gene name synonym)|uniprotkb:Axis inhibition protein 1(gene name synonym)|uniprotkb:Protein Fused(gene name synonym) psi-mi:"MI:0018"(two hybrid) Matsui et al. (2008) pubmed:18786926|mint:MINT-7215866|doi:10.1074/jbc.M800420200 taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)") taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8069672|mint:MINT-7305259 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR032038|interpro:IPR009224(SAMP)|interpro:IPR026818|interpro:IPR000225(Armadillo)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR009234(APC basic)|interpro:IPR009240(APC 15 residue)|refseq:NP_001084351.1|interpro:IPR026831|interpro:IPR009223(APC cysteine-rich)|interpro:IPR009232(EB-1 binding)|interpro:IPR026836|mint:P70039|interpro:IPR036149|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000776"(kinetochore)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016477"(cell migration)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0008017"(microtubule binding)|interpro:IPR041257|mint:MINT-7305261(identity) dip:DIP-42637N|refseq:NP_033863.2|mint:O35625|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002039"(p53 binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006913"(nucleocytoplasmic transport)|go:"GO:0006915"(apoptotic process)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009950"(dorsal/ventral axis specification)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034244"(negative regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0034622"|go:"GO:0036342"(post-anal tail morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046332"(SMAD binding)|go:"GO:0048318"(axial mesoderm development)|go:"GO:0048320"(axial mesoderm formation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051248"(negative regulation of protein metabolic process)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060322"(head development)|go:"GO:0060828"(regulation of canonical Wnt signaling pathway)|go:"GO:0070016"(armadillo repeat domain binding)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0071514"(genomic imprinting)|go:"GO:0071944"(cell periphery)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR001158(DIX)|interpro:IPR014936(Axin beta-catenin binding)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR024066|interpro:IPR029071|interpro:IPR029797|interpro:IPR032101|interpro:IPR036305|interpro:IPR038207|interpro:IPR043581|rcsb pdb:3UTM|reactome:R-MMU-195253|reactome:R-MMU-196299|reactome:R-MMU-201681|reactome:R-MMU-4641257|reactome:R-MMU-4641262|reactome:R-MMU-5689880|mint:MINT-7305262(identity) - comment:mint - comment:domino|comment:mint|figure legend:f2b n f|partial coverage:partial coverage|curation depth:mimix curation taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2009/11/25 2014/10/16 rogid:yLh0z/FKIjP6FESc7rOFIexnbjM8355 rogid:FOkurPV4xIeQZatHupnfK6/4CKA10090 intact-crc:B6D04EFD171E105C|rigid:PUGZaYmO/JtoRaMbgxrTNtBNq04 false binding-associated region:1565-1594(MINT-7305271) - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q7SIG6 uniprotkb:P70039 intact:EBI-8069706|uniprotkb:Q501K1|uniprotkb:Q66JN2|intact:UNK-5493872|ensembl:ENSMUSP00000099098 intact:EBI-8069633|uniprotkb:P79934|intact:MINT-7305229 psi-mi:asap2_mouse(display_long)|uniprotkb:Asap2(gene name)|psi-mi:Asap2(display_short)|uniprotkb:Gm592(gene name synonym)|uniprotkb:Paxillin-associated protein with ARF GAP activity 3(gene name synonym)|uniprotkb:Pyk2 C-terminus-associated protein(gene name synonym)|uniprotkb:Ddef2(gene name synonym)|uniprotkb:Development and differentiation-enhancing factor 2(gene name synonym)|uniprotkb:Gm1523(gene name synonym) psi-mi:apc_xenla(display_long)|uniprotkb:apc(gene name)|psi-mi:apc(display_short) psi-mi:"MI:0018"(two hybrid) Matsui et al. (2008) pubmed:18786926|mint:MINT-7215866|doi:10.1074/jbc.M800420200 taxid:10090(mouse)|taxid:10090(Mus musculus) taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8069742|mint:MINT-7305275 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001128664.1|refseq:NP_001091637.1|refseq:NP_001004364.2|ensembl:ENSMUSG00000052632(gene)|ensembl:ENSMUST00000101562(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0032580"(Golgi cisterna membrane)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0046872"(metal ion binding)|interpro:IPR001164(Arf GTPase activating protein)|interpro:IPR001452(Src homology-3)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002110(Ankyrin)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR020683|interpro:IPR027267|interpro:IPR035677|interpro:IPR036028|interpro:IPR036770|interpro:IPR037278|interpro:IPR037844|interpro:IPR038508|interpro:IPR043593|mint:Q7SIG6|rcsb pdb:1DCQ|mint:MINT-7305277(identity) interpro:IPR032038|interpro:IPR009224(SAMP)|interpro:IPR026818|interpro:IPR000225(Armadillo)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR009234(APC basic)|interpro:IPR009240(APC 15 residue)|refseq:NP_001084351.1|interpro:IPR026831|interpro:IPR009223(APC cysteine-rich)|interpro:IPR009232(EB-1 binding)|interpro:IPR026836|mint:P70039|interpro:IPR036149|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000776"(kinetochore)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016477"(cell migration)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0008017"(microtubule binding)|interpro:IPR041257|mint:MINT-7305279(identity) - comment:mint|function:Activates the small GTPases ARF1, ARF5 and ARF6. Regulates the formation of post-Golgi vesicles and modulates constitutive secretion. Modulates phagocytosis mediated by Fc gamma receptor and ARF6. Modulates PXN recruitment to focal contacts and cell migration comment:mint comment:domino|comment:mint|figure legend:f2b n f|partial coverage:partial coverage|curation depth:mimix curation taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2009/11/25 2014/10/16 rogid:o804o1uwQJ8FAb3qdEE2r7ZfOIg10090 rogid:yLh0z/FKIjP6FESc7rOFIexnbjM8355 intact-crc:7531C7DA7CEFA734|rigid:Zz98kES0bxS/bUlOgGeOwz/dRUo false binding-associated region:?-?(MINT-7305296) binding-associated region:1565-1594(MINT-7305280) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P70039 uniprotkb:Q6ZQ82 intact:EBI-8069633|uniprotkb:P79934|intact:MINT-7305229 intact:EBI-7448026|uniprotkb:E9QLL3|intact:UNK-5489886|ensembl:ENSMUSP00000095200 psi-mi:apc_xenla(display_long)|uniprotkb:apc(gene name)|psi-mi:apc(display_short) psi-mi:rhg26_mouse(display_long)|uniprotkb:Kiaa0621(gene name synonym)|uniprotkb:Rho-type GTPase-activating protein 26(gene name synonym)|uniprotkb:Arhgap26(gene name)|psi-mi:Arhgap26(display_short) psi-mi:"MI:0018"(two hybrid) Matsui et al. (2008) pubmed:18786926|mint:MINT-7215866|doi:10.1074/jbc.M800420200 taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)") taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8069764|mint:MINT-7305320 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR032038|interpro:IPR009224(SAMP)|interpro:IPR026818|interpro:IPR000225(Armadillo)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR009234(APC basic)|interpro:IPR009240(APC 15 residue)|refseq:NP_001084351.1|interpro:IPR026831|interpro:IPR009223(APC cysteine-rich)|interpro:IPR009232(EB-1 binding)|interpro:IPR026836|mint:P70039|interpro:IPR036149|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000776"(kinetochore)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016477"(cell migration)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0008017"(microtubule binding)|interpro:IPR041257|mint:MINT-7305327(identity) refseq:NP_780373.3|ensembl:ENSMUSG00000036452(gene)|ensembl:ENSMUST00000097593(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005925"(focal adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|interpro:IPR000198(RhoGAP)|interpro:IPR001452(Src homology-3)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR027267|interpro:IPR030061|interpro:IPR035481|interpro:IPR035483|interpro:IPR036028|mint:Q6ZQ82|reactome:R-MMU-8980692|reactome:R-MMU-9013026|reactome:R-MMU-9013106|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013405|reactome:R-MMU-9013406|reactome:R-MMU-9013409|reactome:R-MMU-9013423|mint:MINT-7305322(identity) - comment:mint comment:"fragmentation type: fragment"|comment:mint comment:domino|comment:mint|figure legend:f2b n f|partial coverage:partial coverage|curation depth:mimix curation taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2009/11/25 2014/10/16 rogid:yLh0z/FKIjP6FESc7rOFIexnbjM8355 rogid:xw4yoHvZHWEtGCr4nVzZHPmUThY10090 intact-crc:AB98375A653A8C55|rigid:K3if/es8f24t4Ky3bqUJvOvTr8w false binding-associated region:1565-1594(MINT-7305328) binding-associated region:723-781(MINT-7305323) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P70039 uniprotkb:Q9ESK9 intact:EBI-8069633|uniprotkb:P79934|intact:MINT-7305229 intact:EBI-647302|uniprotkb:E9QLQ2|uniprotkb:Q3TXX2|uniprotkb:Q61384|uniprotkb:Q8BRY9|uniprotkb:Q9JK14|ensembl:ENSMUSP00000027040 psi-mi:apc_xenla(display_long)|uniprotkb:apc(gene name)|psi-mi:apc(display_short) psi-mi:rbcc1_mouse(display_long)|uniprotkb:Coiled-coil-forming protein 1(gene name synonym)|uniprotkb:LaXp180(gene name synonym)|uniprotkb:Rb1cc1(gene name)|psi-mi:Rb1cc1(display_short)|uniprotkb:Cc1(gene name synonym)|uniprotkb:Kiaa0203(gene name synonym)|uniprotkb:FAK family kinase-interacting protein of 200 kDa(gene name synonym) psi-mi:"MI:0018"(two hybrid) Matsui et al. (2008) pubmed:18786926|mint:MINT-7215866|doi:10.1074/jbc.M800420200 taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)") taxid:10090(mouse)|taxid:10090(Mus musculus) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8069784|mint:MINT-7305372 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR032038|interpro:IPR009224(SAMP)|interpro:IPR026818|interpro:IPR000225(Armadillo)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR009234(APC basic)|interpro:IPR009240(APC 15 residue)|refseq:NP_001084351.1|interpro:IPR026831|interpro:IPR009223(APC cysteine-rich)|interpro:IPR009232(EB-1 binding)|interpro:IPR026836|mint:P70039|interpro:IPR036149|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000776"(kinetochore)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016477"(cell migration)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0008017"(microtubule binding)|interpro:IPR041257|mint:MINT-7305379(identity) refseq:NP_033956.2|dip:DIP-49679N|ensembl:ENSMUSG00000025907(gene)|ensembl:ENSMUST00000027040(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0001889"(liver development)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0007049"(cell cycle)|go:"GO:0007507"(heart development)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030242"(autophagy of peroxisome)|go:"GO:0031965"(nuclear membrane)|go:"GO:0034045"(phagophore assembly site membrane)|go:"GO:0034727"(piecemeal microautophagy of the nucleus)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061709"(reticulophagy)|go:"GO:0061723"(glycophagy)|go:"GO:1990316"(Atg1/ULK1 kinase complex)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR019460|interpro:IPR040040|mint:Q9ESK9|reactome:R-MMU-1632852|mint:MINT-7305374(identity) - comment:mint - comment:domino|comment:mint|figure legend:f2b n f|partial coverage:partial coverage|curation depth:mimix curation taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae) - 2009/11/25 2014/10/16 rogid:yLh0z/FKIjP6FESc7rOFIexnbjM8355 rogid:DiOKxKS7K4NtKX4DqF9ZtpkcOcc10090 intact-crc:553A68907087D64D|rigid:XtDI3jqXsvrrkgJiETePYvGgCIc false binding-associated region:1565-1594(MINT-7305380) - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P70039 uniprotkb:Q9ULH1 intact:EBI-8069633|uniprotkb:P79934|intact:MINT-7305229 intact:EBI-346622|uniprotkb:B2RNV3|ensembl:ENSP00000429900 psi-mi:apc_xenla(display_long)|uniprotkb:apc(gene name)|psi-mi:apc(display_short) psi-mi:asap1_human(display_long)|uniprotkb:ASAP1(gene name)|psi-mi:ASAP1(display_short)|uniprotkb:DDEF1(gene name synonym)|uniprotkb:KIAA1249(gene name synonym)|uniprotkb:PIP2-dependent ARF1 GAP(gene name synonym)|uniprotkb:ADP-ribosylation factor-directed GTPase-activating protein 1(gene name synonym)|uniprotkb:Development and differentiation-enhancing factor 1(gene name synonym)|uniprotkb:130 kDa phosphatidylinositol 4,5-bisphosphate-dependent ARF1 GTPase-activating protein(gene name synonym)|uniprotkb:PAG2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Matsui et al. (2008) pubmed:18786926|mint:MINT-7215866|doi:10.1074/jbc.M800420200 taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8069830|mint:MINT-7305453 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR032038|interpro:IPR009224(SAMP)|interpro:IPR026818|interpro:IPR000225(Armadillo)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR009234(APC basic)|interpro:IPR009240(APC 15 residue)|refseq:NP_001084351.1|interpro:IPR026831|interpro:IPR009223(APC cysteine-rich)|interpro:IPR009232(EB-1 binding)|interpro:IPR026836|mint:P70039|interpro:IPR036149|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000776"(kinetochore)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016477"(cell migration)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0008017"(microtubule binding)|interpro:IPR041257|mint:MINT-7305455(identity) refseq:XP_006716626.1|refseq:XP_005250982.1|refseq:NP_060952.2|ensembl:ENSP00000429900|refseq:NP_001234925.1|refseq:XP_011515354.1|rcsb pdb:2DA0|rcsb pdb:2ED1|rcsb pdb:2RQT|rcsb pdb:2RQU|reactome:R-HSA-5620916|ensembl:ENSG00000153317(gene)|ensembl:ENST00000518721(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0002102"(podosome)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005829"(cytosol)|go:"GO:0031253"(cell projection membrane)|go:"GO:0043197"(dendritic spine)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045296"(cadherin binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0060271"(cilium assembly)|go:"GO:0061000"(negative regulation of dendritic spine development)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:1903527"(positive regulation of membrane tubulation)|interpro:IPR001164(Arf GTPase activating protein)|interpro:IPR001452(Src homology-3)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002110(Ankyrin)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR020683|interpro:IPR027267|interpro:IPR036028|interpro:IPR036770|interpro:IPR037278|interpro:IPR037844|interpro:IPR037928|interpro:IPR038016|interpro:IPR038508|interpro:IPR043593|mint:Q9ULH1|rcsb pdb:2D1X|mint:MINT-7305456(identity) - comment:mint - figure legend:f2c|comment:mint|comment:xenopus laevis DDEF1 accession number has been inferred to the human one.|partial coverage:partial coverage|curation depth:mimix curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2009/11/25 2014/10/16 rogid:yLh0z/FKIjP6FESc7rOFIexnbjM8355 rogid:SNTUJDKJY1SYZwUBev1peWcNArw9606 intact-crc:EE20C90C58EDBF3C|rigid:PyzuXZ0fS/5StwNzHOcpGsEvAYs false green fluorescent protein tag:?-?(MINT-7305462) tag:?-?(MINT-7305458) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P70039 uniprotkb:Q9YGY0 intact:EBI-8069633|uniprotkb:P79934|intact:MINT-7305229 intact:EBI-1037449 psi-mi:apc_xenla(display_long)|uniprotkb:apc(gene name)|psi-mi:apc(display_short) psi-mi:axin1_xenla(display_long)|uniprotkb:axin1(gene name)|psi-mi:axin1(display_short)|uniprotkb:axn(gene name synonym)|uniprotkb:axin(gene name synonym)|uniprotkb:Axis inhibition protein 1(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Matsui et al. (2008) pubmed:18786926|mint:MINT-7215866|doi:10.1074/jbc.M800420200 taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)") taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8069866|mint:MINT-7305480 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR032038|interpro:IPR009224(SAMP)|interpro:IPR026818|interpro:IPR000225(Armadillo)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR009234(APC basic)|interpro:IPR009240(APC 15 residue)|refseq:NP_001084351.1|interpro:IPR026831|interpro:IPR009223(APC cysteine-rich)|interpro:IPR009232(EB-1 binding)|interpro:IPR026836|mint:P70039|interpro:IPR036149|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000776"(kinetochore)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016477"(cell migration)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0008017"(microtubule binding)|interpro:IPR041257|mint:MINT-7305486(identity) refseq:NP_001081874.1|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:2000054"(negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification)|interpro:IPR001158(DIX)|interpro:IPR014936(Axin beta-catenin binding)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR024066|interpro:IPR029071|interpro:IPR029797|interpro:IPR032101|interpro:IPR036305|interpro:IPR038207|interpro:IPR043581|rcsb pdb:1QZ7|mint:Q9YGY0|dip:DIP-36387N|mint:MINT-7305482(identity) - comment:mint - figure legend:f2c|comment:mint|partial coverage:partial coverage|curation depth:mimix curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2009/11/25 2014/10/16 rogid:yLh0z/FKIjP6FESc7rOFIexnbjM8355 rogid:qPbg91eVSV0hDg534SxILqM0bG08355 intact-crc:4684070755084B9B|rigid:b+EhSuMxi2CP87Npi7vovMOR4sA false green fluorescent protein tag:?-?(MINT-7305487) tag:?-?(MINT-7305483) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P70039 uniprotkb:O43150 intact:EBI-8069633|uniprotkb:P79934|intact:MINT-7305229 intact:EBI-310968|uniprotkb:D6W4Y8|ensembl:ENSP00000281419 psi-mi:apc_xenla(display_long)|uniprotkb:apc(gene name)|psi-mi:apc(display_short) psi-mi:asap2_human(display_long)|uniprotkb:ASAP2(gene name)|psi-mi:ASAP2(display_short)|uniprotkb:KIAA0400(gene name synonym)|uniprotkb:Pyk2 C-terminus-associated protein(gene name synonym)|uniprotkb:Paxillin-associated protein with ARF GAP activity 3(gene name synonym)|uniprotkb:DDEF2(gene name synonym)|uniprotkb:Development and differentiation-enhancing factor 2(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Matsui et al. (2008) pubmed:18786926|mint:MINT-7215866|doi:10.1074/jbc.M800420200 taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8069848|mint:MINT-7305466 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR032038|interpro:IPR009224(SAMP)|interpro:IPR026818|interpro:IPR000225(Armadillo)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR009234(APC basic)|interpro:IPR009240(APC 15 residue)|refseq:NP_001084351.1|interpro:IPR026831|interpro:IPR009223(APC cysteine-rich)|interpro:IPR009232(EB-1 binding)|interpro:IPR026836|mint:P70039|interpro:IPR036149|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000776"(kinetochore)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016477"(cell migration)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0008017"(microtubule binding)|interpro:IPR041257|mint:MINT-7305472(identity) ensembl:ENSP00000281419|ensembl:ENST00000315273|ensembl:ENSP00000316404|refseq:NP_001128663.1|refseq:NP_003878.1|ensembl:ENSG00000151693(gene)|ensembl:ENST00000281419(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0032580"(Golgi cisterna membrane)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0046872"(metal ion binding)|interpro:IPR001164(Arf GTPase activating protein)|interpro:IPR001452(Src homology-3)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002110(Ankyrin)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR020683|interpro:IPR027267|interpro:IPR035677|interpro:IPR036028|interpro:IPR036770|interpro:IPR037278|interpro:IPR037844|interpro:IPR038508|interpro:IPR043593|mint:O43150|mint:MINT-7305468(identity) - comment:mint - figure legend:f2c|comment:mint|comment:xenopus laevis DDEF2 accession number has been inferred to the human one.|partial coverage:partial coverage|curation depth:mimix curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2009/11/25 2014/10/16 rogid:yLh0z/FKIjP6FESc7rOFIexnbjM8355 rogid:Ye0xTNuPq3d3/1y/2mIFYH9ecNs9606 intact-crc:E86F59173A740693|rigid:AuiV4uA3u9L8TNZEP52/+cs+UoA false green fluorescent protein tag:?-?(MINT-7305473) tag:?-?(MINT-7305469) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P70039 uniprotkb:Q9ULH1 intact:EBI-8069633|uniprotkb:P79934|intact:MINT-7305229 intact:EBI-346622|uniprotkb:B2RNV3|ensembl:ENSP00000429900 psi-mi:apc_xenla(display_long)|uniprotkb:apc(gene name)|psi-mi:apc(display_short) psi-mi:asap1_human(display_long)|uniprotkb:ASAP1(gene name)|psi-mi:ASAP1(display_short)|uniprotkb:DDEF1(gene name synonym)|uniprotkb:KIAA1249(gene name synonym)|uniprotkb:PIP2-dependent ARF1 GAP(gene name synonym)|uniprotkb:ADP-ribosylation factor-directed GTPase-activating protein 1(gene name synonym)|uniprotkb:Development and differentiation-enhancing factor 1(gene name synonym)|uniprotkb:130 kDa phosphatidylinositol 4,5-bisphosphate-dependent ARF1 GTPase-activating protein(gene name synonym)|uniprotkb:PAG2(gene name synonym) psi-mi:"MI:0096"(pull down) Matsui et al. (2008) pubmed:18786926|mint:MINT-7215866|doi:10.1074/jbc.M800420200 taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8069895|mint:MINT-7305514 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR032038|interpro:IPR009224(SAMP)|interpro:IPR026818|interpro:IPR000225(Armadillo)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR009234(APC basic)|interpro:IPR009240(APC 15 residue)|refseq:NP_001084351.1|interpro:IPR026831|interpro:IPR009223(APC cysteine-rich)|interpro:IPR009232(EB-1 binding)|interpro:IPR026836|mint:P70039|interpro:IPR036149|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000776"(kinetochore)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016477"(cell migration)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0008017"(microtubule binding)|interpro:IPR041257|mint:MINT-7305520(identity) refseq:XP_006716626.1|refseq:XP_005250982.1|refseq:NP_060952.2|ensembl:ENSP00000429900|refseq:NP_001234925.1|refseq:XP_011515354.1|rcsb pdb:2DA0|rcsb pdb:2ED1|rcsb pdb:2RQT|rcsb pdb:2RQU|reactome:R-HSA-5620916|ensembl:ENSG00000153317(gene)|ensembl:ENST00000518721(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0002102"(podosome)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005829"(cytosol)|go:"GO:0031253"(cell projection membrane)|go:"GO:0043197"(dendritic spine)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045296"(cadherin binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0060271"(cilium assembly)|go:"GO:0061000"(negative regulation of dendritic spine development)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:1903527"(positive regulation of membrane tubulation)|interpro:IPR001164(Arf GTPase activating protein)|interpro:IPR001452(Src homology-3)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002110(Ankyrin)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR020683|interpro:IPR027267|interpro:IPR036028|interpro:IPR036770|interpro:IPR037278|interpro:IPR037844|interpro:IPR037928|interpro:IPR038016|interpro:IPR038508|interpro:IPR043593|mint:Q9ULH1|rcsb pdb:2D1X|mint:MINT-7305516(identity) - comment:mint - figure legend:f3b|comment:domino|comment:mint|comment:xenopus laevis DDEF1 accession number has been inferred to the human one.|partial coverage:partial coverage|curation depth:mimix curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2009/11/25 2014/10/16 rogid:yLh0z/FKIjP6FESc7rOFIexnbjM8355 rogid:SNTUJDKJY1SYZwUBev1peWcNArw9606 intact-crc:15F547550EE2597B|rigid:PyzuXZ0fS/5StwNzHOcpGsEvAYs false flag tag:?-?(MINT-7305521)|binding-associated region:1565-1594(MINT-7305526) binding-associated region:1067-1129(MINT-7305530)|tag:?-?(MINT-7305517) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P70039 uniprotkb:O43150 intact:EBI-8069633|uniprotkb:P79934|intact:MINT-7305229 intact:EBI-310968|uniprotkb:D6W4Y8|ensembl:ENSP00000281419 psi-mi:apc_xenla(display_long)|uniprotkb:apc(gene name)|psi-mi:apc(display_short) psi-mi:asap2_human(display_long)|uniprotkb:ASAP2(gene name)|psi-mi:ASAP2(display_short)|uniprotkb:KIAA0400(gene name synonym)|uniprotkb:Pyk2 C-terminus-associated protein(gene name synonym)|uniprotkb:Paxillin-associated protein with ARF GAP activity 3(gene name synonym)|uniprotkb:DDEF2(gene name synonym)|uniprotkb:Development and differentiation-enhancing factor 2(gene name synonym) psi-mi:"MI:0096"(pull down) Matsui et al. (2008) pubmed:18786926|mint:MINT-7215866|doi:10.1074/jbc.M800420200 taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8069922|mint:MINT-7305534 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR032038|interpro:IPR009224(SAMP)|interpro:IPR026818|interpro:IPR000225(Armadillo)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR009234(APC basic)|interpro:IPR009240(APC 15 residue)|refseq:NP_001084351.1|interpro:IPR026831|interpro:IPR009223(APC cysteine-rich)|interpro:IPR009232(EB-1 binding)|interpro:IPR026836|mint:P70039|interpro:IPR036149|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000776"(kinetochore)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016477"(cell migration)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0008017"(microtubule binding)|interpro:IPR041257|mint:MINT-7305536(identity) ensembl:ENSP00000281419|ensembl:ENST00000315273|ensembl:ENSP00000316404|refseq:NP_001128663.1|refseq:NP_003878.1|ensembl:ENSG00000151693(gene)|ensembl:ENST00000281419(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0032580"(Golgi cisterna membrane)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0046872"(metal ion binding)|interpro:IPR001164(Arf GTPase activating protein)|interpro:IPR001452(Src homology-3)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002110(Ankyrin)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR020683|interpro:IPR027267|interpro:IPR035677|interpro:IPR036028|interpro:IPR036770|interpro:IPR037278|interpro:IPR037844|interpro:IPR038508|interpro:IPR043593|mint:O43150|mint:MINT-7305543(identity) - comment:mint - figure legend:f3b|comment:domino|comment:mint|comment:xenopus laevis DDEF2 accession number has been inferred to the human one.|partial coverage:partial coverage|curation depth:mimix curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2009/11/25 2014/10/16 rogid:yLh0z/FKIjP6FESc7rOFIexnbjM8355 rogid:Ye0xTNuPq3d3/1y/2mIFYH9ecNs9606 intact-crc:48C22BC7D3540540|rigid:AuiV4uA3u9L8TNZEP52/+cs+UoA false flag tag:?-?(MINT-7305537)|binding-associated region:1565-1594(MINT-7305539) tag:?-?(MINT-7305547)|binding-associated region:944-1006(MINT-7305544) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P70039 uniprotkb:Q9YGY0 intact:EBI-8069633|uniprotkb:P79934|intact:MINT-7305229 intact:EBI-1037449 psi-mi:apc_xenla(display_long)|uniprotkb:apc(gene name)|psi-mi:apc(display_short) psi-mi:axin1_xenla(display_long)|uniprotkb:axin1(gene name)|psi-mi:axin1(display_short)|uniprotkb:axn(gene name synonym)|uniprotkb:axin(gene name synonym)|uniprotkb:Axis inhibition protein 1(gene name synonym) psi-mi:"MI:0096"(pull down) Matsui et al. (2008) pubmed:18786926|mint:MINT-7215866|doi:10.1074/jbc.M800420200 taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)") taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8069949|mint:MINT-7305557 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR032038|interpro:IPR009224(SAMP)|interpro:IPR026818|interpro:IPR000225(Armadillo)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR009234(APC basic)|interpro:IPR009240(APC 15 residue)|refseq:NP_001084351.1|interpro:IPR026831|interpro:IPR009223(APC cysteine-rich)|interpro:IPR009232(EB-1 binding)|interpro:IPR026836|mint:P70039|interpro:IPR036149|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000776"(kinetochore)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016477"(cell migration)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0008017"(microtubule binding)|interpro:IPR041257|mint:MINT-7305563(identity) refseq:NP_001081874.1|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:2000054"(negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification)|interpro:IPR001158(DIX)|interpro:IPR014936(Axin beta-catenin binding)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR024066|interpro:IPR029071|interpro:IPR029797|interpro:IPR032101|interpro:IPR036305|interpro:IPR038207|interpro:IPR043581|rcsb pdb:1QZ7|mint:Q9YGY0|dip:DIP-36387N|mint:MINT-7305559(identity) - comment:mint - figure legend:f2c|comment:domino|comment:mint|partial coverage:partial coverage|curation depth:mimix curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2009/11/25 2014/10/16 rogid:yLh0z/FKIjP6FESc7rOFIexnbjM8355 rogid:qPbg91eVSV0hDg534SxILqM0bG08355 intact-crc:67BED32084E39ACF|rigid:b+EhSuMxi2CP87Npi7vovMOR4sA false flag tag:?-?(MINT-7305564)|binding-associated region:1565-1594(MINT-7305573) tag:?-?(MINT-7305560)|binding-associated region:88-211(MINT-7305569) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P70039 uniprotkb:O15169 intact:EBI-8069633|uniprotkb:P79934|intact:MINT-7305229 intact:EBI-710484|uniprotkb:Q4TT26|uniprotkb:Q4TT27|ensembl:ENSP00000262320|uniprotkb:Q86YA7|uniprotkb:Q8WVW6|uniprotkb:Q96S28 psi-mi:apc_xenla(display_long)|uniprotkb:apc(gene name)|psi-mi:apc(display_short) psi-mi:axin1_human(display_long)|uniprotkb:Axis inhibition protein 1(gene name synonym)|uniprotkb:AXIN1(gene name)|psi-mi:AXIN1(display_short)|uniprotkb:AXIN(gene name synonym) psi-mi:"MI:0077"(nuclear magnetic resonance) Matsui et al. (2008) pubmed:18786926|mint:MINT-7215866|doi:10.1074/jbc.M800420200 taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8070005|mint:MINT-7305577 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR032038|interpro:IPR009224(SAMP)|interpro:IPR026818|interpro:IPR000225(Armadillo)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR009234(APC basic)|interpro:IPR009240(APC 15 residue)|refseq:NP_001084351.1|interpro:IPR026831|interpro:IPR009223(APC cysteine-rich)|interpro:IPR009232(EB-1 binding)|interpro:IPR026836|mint:P70039|interpro:IPR036149|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000776"(kinetochore)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016477"(cell migration)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0008017"(microtubule binding)|interpro:IPR041257|mint:MINT-7305579(identity) refseq:NP_003493.1|refseq:NP_851393.1|ensembl:ENSG00000103126(gene)|ensembl:ENST00000262320(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034622"|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046332"(SMAD binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070016"(armadillo repeat domain binding)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0071944"(cell periphery)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR001158(DIX)|interpro:IPR014936(Axin beta-catenin binding)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR024066|interpro:IPR029071|interpro:IPR029797|interpro:IPR032101|interpro:IPR036305|interpro:IPR038207|interpro:IPR043581|mint:O15169|rcsb pdb:1DK8|rcsb pdb:1EMU|rcsb pdb:1O9U|rcsb pdb:3ZDI|rcsb pdb:4B7T|rcsb pdb:4NM0|rcsb pdb:4NM3|rcsb pdb:4NM5|rcsb pdb:4NM7|rcsb pdb:4NU1|rcsb pdb:5WZZ|rcsb pdb:6JCK|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-201681|reactome:R-HSA-4641257|reactome:R-HSA-4641262|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5467337|reactome:R-HSA-5467340|reactome:R-HSA-5467348|reactome:R-HSA-5689880|reactome:R-HSA-8931987|reactome:R-HSA-8939256|reactome:R-HSA-9018519|dip:DIP-34630N|mint:MINT-7305586(identity) - comment:mint - comment:domino|comment:mint|figure legend:f4a f4d|partial coverage:partial coverage|curation depth:mimix curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2009/11/25 2014/10/16 rogid:yLh0z/FKIjP6FESc7rOFIexnbjM8355 rogid:uO+LxY/7ibIZqdd5onbfXqGAZeo9606 intact-crc:ED9201C689FE1F94|rigid:QBnh8YO9Yocw9/MEWGDuB+6ClGQ false binding-associated region:1565-1594(MINT-7305582) binding-associated region:88-211(MINT-7305587) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P70039 uniprotkb:O43150 intact:EBI-8069633|uniprotkb:P79934|intact:MINT-7305229 intact:EBI-310968|uniprotkb:D6W4Y8|ensembl:ENSP00000281419 psi-mi:apc_xenla(display_long)|uniprotkb:apc(gene name)|psi-mi:apc(display_short) psi-mi:asap2_human(display_long)|uniprotkb:ASAP2(gene name)|psi-mi:ASAP2(display_short)|uniprotkb:KIAA0400(gene name synonym)|uniprotkb:Pyk2 C-terminus-associated protein(gene name synonym)|uniprotkb:Paxillin-associated protein with ARF GAP activity 3(gene name synonym)|uniprotkb:DDEF2(gene name synonym)|uniprotkb:Development and differentiation-enhancing factor 2(gene name synonym) psi-mi:"MI:0077"(nuclear magnetic resonance) Matsui et al. (2008) pubmed:18786926|mint:MINT-7215866|doi:10.1074/jbc.M800420200 taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8070045|mint:MINT-7305618 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR032038|interpro:IPR009224(SAMP)|interpro:IPR026818|interpro:IPR000225(Armadillo)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR009234(APC basic)|interpro:IPR009240(APC 15 residue)|refseq:NP_001084351.1|interpro:IPR026831|interpro:IPR009223(APC cysteine-rich)|interpro:IPR009232(EB-1 binding)|interpro:IPR026836|mint:P70039|interpro:IPR036149|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000776"(kinetochore)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016477"(cell migration)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0008017"(microtubule binding)|interpro:IPR041257|mint:MINT-7305625(identity) ensembl:ENSP00000281419|ensembl:ENST00000315273|ensembl:ENSP00000316404|refseq:NP_001128663.1|refseq:NP_003878.1|ensembl:ENSG00000151693(gene)|ensembl:ENST00000281419(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0032580"(Golgi cisterna membrane)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0046872"(metal ion binding)|interpro:IPR001164(Arf GTPase activating protein)|interpro:IPR001452(Src homology-3)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002110(Ankyrin)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR020683|interpro:IPR027267|interpro:IPR035677|interpro:IPR036028|interpro:IPR036770|interpro:IPR037278|interpro:IPR037844|interpro:IPR038508|interpro:IPR043593|mint:O43150|mint:MINT-7305620(identity) - comment:mint - figure legend:f4d|comment:domino|comment:mint|partial coverage:partial coverage|curation depth:mimix curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2009/11/25 2014/10/16 rogid:yLh0z/FKIjP6FESc7rOFIexnbjM8355 rogid:Ye0xTNuPq3d3/1y/2mIFYH9ecNs9606 intact-crc:4552AEE6380CF6F5|rigid:AuiV4uA3u9L8TNZEP52/+cs+UoA false binding-associated region:2031-2048(MINT-7305626) binding-associated region:944-1006(MINT-7305621) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P70039 uniprotkb:Q9ULH1 intact:EBI-8069633|uniprotkb:P79934|intact:MINT-7305229 intact:EBI-346622|uniprotkb:B2RNV3|ensembl:ENSP00000429900 psi-mi:apc_xenla(display_long)|uniprotkb:apc(gene name)|psi-mi:apc(display_short) psi-mi:asap1_human(display_long)|uniprotkb:ASAP1(gene name)|psi-mi:ASAP1(display_short)|uniprotkb:DDEF1(gene name synonym)|uniprotkb:KIAA1249(gene name synonym)|uniprotkb:PIP2-dependent ARF1 GAP(gene name synonym)|uniprotkb:ADP-ribosylation factor-directed GTPase-activating protein 1(gene name synonym)|uniprotkb:Development and differentiation-enhancing factor 1(gene name synonym)|uniprotkb:130 kDa phosphatidylinositol 4,5-bisphosphate-dependent ARF1 GTPase-activating protein(gene name synonym)|uniprotkb:PAG2(gene name synonym) psi-mi:"MI:0077"(nuclear magnetic resonance) Matsui et al. (2008) pubmed:18786926|mint:MINT-7215866|doi:10.1074/jbc.M800420200 taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8070025|mint:MINT-7305602 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR032038|interpro:IPR009224(SAMP)|interpro:IPR026818|interpro:IPR000225(Armadillo)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR009234(APC basic)|interpro:IPR009240(APC 15 residue)|refseq:NP_001084351.1|interpro:IPR026831|interpro:IPR009223(APC cysteine-rich)|interpro:IPR009232(EB-1 binding)|interpro:IPR026836|mint:P70039|interpro:IPR036149|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000776"(kinetochore)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016477"(cell migration)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0008017"(microtubule binding)|interpro:IPR041257|mint:MINT-7305609(identity) refseq:XP_006716626.1|refseq:XP_005250982.1|refseq:NP_060952.2|ensembl:ENSP00000429900|refseq:NP_001234925.1|refseq:XP_011515354.1|rcsb pdb:2DA0|rcsb pdb:2ED1|rcsb pdb:2RQT|rcsb pdb:2RQU|reactome:R-HSA-5620916|ensembl:ENSG00000153317(gene)|ensembl:ENST00000518721(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0002102"(podosome)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005829"(cytosol)|go:"GO:0031253"(cell projection membrane)|go:"GO:0043197"(dendritic spine)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045296"(cadherin binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0060271"(cilium assembly)|go:"GO:0061000"(negative regulation of dendritic spine development)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:1903527"(positive regulation of membrane tubulation)|interpro:IPR001164(Arf GTPase activating protein)|interpro:IPR001452(Src homology-3)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002110(Ankyrin)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR020683|interpro:IPR027267|interpro:IPR036028|interpro:IPR036770|interpro:IPR037278|interpro:IPR037844|interpro:IPR037928|interpro:IPR038016|interpro:IPR038508|interpro:IPR043593|mint:Q9ULH1|rcsb pdb:2D1X|mint:MINT-7305604(identity) - comment:mint - figure legend:f4d|comment:domino|comment:mint|partial coverage:partial coverage|curation depth:mimix curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2009/11/25 2014/10/16 rogid:yLh0z/FKIjP6FESc7rOFIexnbjM8355 rogid:SNTUJDKJY1SYZwUBev1peWcNArw9606 intact-crc:02EC6B776946840A|rigid:PyzuXZ0fS/5StwNzHOcpGsEvAYs false binding-associated region:1718-1738(MINT-7305610) binding-associated region:1067-1129(MINT-7305605) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q9UNA1 uniprotkb:P70039 intact:EBI-1390913|uniprotkb:O75117|uniprotkb:Q9BYS6|uniprotkb:Q9BYS7|uniprotkb:Q9UJ00|uniprotkb:Q5D035|ensembl:ENSP00000274498 intact:EBI-8069633|uniprotkb:P79934|intact:MINT-7305229 psi-mi:rhg26_human(display_long)|uniprotkb:ARHGAP26(gene name)|psi-mi:ARHGAP26(display_short)|uniprotkb:GRAF(gene name synonym)|uniprotkb:KIAA0621(gene name synonym)|uniprotkb:OPHN1L(gene name synonym)|uniprotkb:Rho-type GTPase-activating protein 26(gene name synonym)|uniprotkb:Oligophrenin-1-like protein(gene name synonym)|uniprotkb:GTPase regulator associated with focal adhesion kinase(gene name synonym) psi-mi:apc_xenla(display_long)|uniprotkb:apc(gene name)|psi-mi:apc(display_short) psi-mi:"MI:0077"(nuclear magnetic resonance) Matsui et al. (2008) pubmed:18786926|mint:MINT-7215866|doi:10.1074/jbc.M800420200 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8070065|mint:MINT-7305633 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:NP_001129080.1|refseq:NP_055886.1|ensembl:ENSG00000145819(gene)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005925"(focal adhesion)|go:"GO:0007165"(signal transduction)|ensembl:ENST00000274498(transcript)|go:"GO:0007399"(nervous system development)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0051056"(regulation of small GTPase mediated signal transduction)|interpro:IPR000198(RhoGAP)|interpro:IPR001452(Src homology-3)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR027267|interpro:IPR030061|interpro:IPR035481|interpro:IPR035483|interpro:IPR036028|mint:Q9UNA1|rcsb pdb:1UGV|reactome:R-HSA-8980692|reactome:R-HSA-9013026|reactome:R-HSA-9013106|reactome:R-HSA-9013148|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013405|reactome:R-HSA-9013406|reactome:R-HSA-9013409|reactome:R-HSA-9013423|mint:MINT-7305635(identity) interpro:IPR032038|interpro:IPR009224(SAMP)|interpro:IPR026818|interpro:IPR000225(Armadillo)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR009234(APC basic)|interpro:IPR009240(APC 15 residue)|refseq:NP_001084351.1|interpro:IPR026831|interpro:IPR009223(APC cysteine-rich)|interpro:IPR009232(EB-1 binding)|interpro:IPR026836|mint:P70039|interpro:IPR036149|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000776"(kinetochore)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016477"(cell migration)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0008017"(microtubule binding)|interpro:IPR041257|mint:MINT-7305640(identity) - - comment:mint figure legend:f4d|comment:domino|comment:mint|partial coverage:partial coverage|curation depth:mimix curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2009/11/25 2014/10/16 rogid:+nfOGTFJ2JEYzI7JSjRbNONtQq09606 rogid:yLh0z/FKIjP6FESc7rOFIexnbjM8355 intact-crc:0D9B772897A5DBCF|rigid:iZWt2aIhjxOiPr9lU1WIqOZlmiI false binding-associated region:756-814(MINT-7305636) binding-associated region:1565-1594(MINT-7305641) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P70039 uniprotkb:Q9ULH1 intact:EBI-8069633|uniprotkb:P79934|intact:MINT-7305229 intact:EBI-346622|uniprotkb:B2RNV3|ensembl:ENSP00000429900 psi-mi:apc_xenla(display_long)|uniprotkb:apc(gene name)|psi-mi:apc(display_short) psi-mi:asap1_human(display_long)|uniprotkb:ASAP1(gene name)|psi-mi:ASAP1(display_short)|uniprotkb:DDEF1(gene name synonym)|uniprotkb:KIAA1249(gene name synonym)|uniprotkb:PIP2-dependent ARF1 GAP(gene name synonym)|uniprotkb:ADP-ribosylation factor-directed GTPase-activating protein 1(gene name synonym)|uniprotkb:Development and differentiation-enhancing factor 1(gene name synonym)|uniprotkb:130 kDa phosphatidylinositol 4,5-bisphosphate-dependent ARF1 GTPase-activating protein(gene name synonym)|uniprotkb:PAG2(gene name synonym) psi-mi:"MI:0077"(nuclear magnetic resonance) Matsui et al. (2008) pubmed:18786926|mint:MINT-7215866|doi:10.1074/jbc.M800420200 taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8070105|mint:MINT-7305666 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR032038|interpro:IPR009224(SAMP)|interpro:IPR026818|interpro:IPR000225(Armadillo)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR009234(APC basic)|interpro:IPR009240(APC 15 residue)|refseq:NP_001084351.1|interpro:IPR026831|interpro:IPR009223(APC cysteine-rich)|interpro:IPR009232(EB-1 binding)|interpro:IPR026836|mint:P70039|interpro:IPR036149|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000776"(kinetochore)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016477"(cell migration)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0008017"(microtubule binding)|interpro:IPR041257|mint:MINT-7305673(identity) refseq:XP_006716626.1|refseq:XP_005250982.1|refseq:NP_060952.2|ensembl:ENSP00000429900|refseq:NP_001234925.1|refseq:XP_011515354.1|rcsb pdb:2DA0|rcsb pdb:2ED1|rcsb pdb:2RQT|rcsb pdb:2RQU|reactome:R-HSA-5620916|ensembl:ENSG00000153317(gene)|ensembl:ENST00000518721(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0002102"(podosome)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005829"(cytosol)|go:"GO:0031253"(cell projection membrane)|go:"GO:0043197"(dendritic spine)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045296"(cadherin binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0060271"(cilium assembly)|go:"GO:0061000"(negative regulation of dendritic spine development)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:1903527"(positive regulation of membrane tubulation)|interpro:IPR001164(Arf GTPase activating protein)|interpro:IPR001452(Src homology-3)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002110(Ankyrin)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR020683|interpro:IPR027267|interpro:IPR036028|interpro:IPR036770|interpro:IPR037278|interpro:IPR037844|interpro:IPR037928|interpro:IPR038016|interpro:IPR038508|interpro:IPR043593|mint:Q9ULH1|rcsb pdb:2D1X|mint:MINT-7305668(identity) - comment:mint - comment:domino|comment:mint|figure legend:f4b f4d f5b f5d|partial coverage:partial coverage|curation depth:mimix curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2009/11/25 2014/10/16 rogid:yLh0z/FKIjP6FESc7rOFIexnbjM8355 rogid:SNTUJDKJY1SYZwUBev1peWcNArw9606 intact-crc:C4CC1017708E1B74|rigid:PyzuXZ0fS/5StwNzHOcpGsEvAYs false binding-associated region:1565-1594(MINT-7305674) binding-associated region:1067-1129(MINT-7305669) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P70039 uniprotkb:O15169 intact:EBI-8069633|uniprotkb:P79934|intact:MINT-7305229 intact:EBI-710484|uniprotkb:Q4TT26|uniprotkb:Q4TT27|ensembl:ENSP00000262320|uniprotkb:Q86YA7|uniprotkb:Q8WVW6|uniprotkb:Q96S28 psi-mi:apc_xenla(display_long)|uniprotkb:apc(gene name)|psi-mi:apc(display_short) psi-mi:axin1_human(display_long)|uniprotkb:Axis inhibition protein 1(gene name synonym)|uniprotkb:AXIN1(gene name)|psi-mi:AXIN1(display_short)|uniprotkb:AXIN(gene name synonym) psi-mi:"MI:0077"(nuclear magnetic resonance) Matsui et al. (2008) pubmed:18786926|mint:MINT-7215866|doi:10.1074/jbc.M800420200 taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8070085|mint:MINT-7305647 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR032038|interpro:IPR009224(SAMP)|interpro:IPR026818|interpro:IPR000225(Armadillo)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR009234(APC basic)|interpro:IPR009240(APC 15 residue)|refseq:NP_001084351.1|interpro:IPR026831|interpro:IPR009223(APC cysteine-rich)|interpro:IPR009232(EB-1 binding)|interpro:IPR026836|mint:P70039|interpro:IPR036149|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000776"(kinetochore)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016477"(cell migration)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0008017"(microtubule binding)|interpro:IPR041257|mint:MINT-7305654(identity) refseq:NP_003493.1|refseq:NP_851393.1|ensembl:ENSG00000103126(gene)|ensembl:ENST00000262320(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006915"(apoptotic process)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034622"|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046332"(SMAD binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051443"(positive regulation of ubiquitin-protein transferase activity)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070016"(armadillo repeat domain binding)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0071944"(cell periphery)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|interpro:IPR001158(DIX)|interpro:IPR014936(Axin beta-catenin binding)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR024066|interpro:IPR029071|interpro:IPR029797|interpro:IPR032101|interpro:IPR036305|interpro:IPR038207|interpro:IPR043581|mint:O15169|rcsb pdb:1DK8|rcsb pdb:1EMU|rcsb pdb:1O9U|rcsb pdb:3ZDI|rcsb pdb:4B7T|rcsb pdb:4NM0|rcsb pdb:4NM3|rcsb pdb:4NM5|rcsb pdb:4NM7|rcsb pdb:4NU1|rcsb pdb:5WZZ|rcsb pdb:6JCK|reactome:R-HSA-195253|reactome:R-HSA-196299|reactome:R-HSA-201681|reactome:R-HSA-4641257|reactome:R-HSA-4641262|reactome:R-HSA-5339716|reactome:R-HSA-5358747|reactome:R-HSA-5358749|reactome:R-HSA-5358751|reactome:R-HSA-5358752|reactome:R-HSA-5467337|reactome:R-HSA-5467340|reactome:R-HSA-5467348|reactome:R-HSA-5689880|reactome:R-HSA-8931987|reactome:R-HSA-8939256|reactome:R-HSA-9018519|dip:DIP-34630N|mint:MINT-7305649(identity) - comment:mint - comment:domino|comment:mint|figure legend:f4d|partial coverage:partial coverage|curation depth:mimix curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2009/11/25 2014/10/16 rogid:yLh0z/FKIjP6FESc7rOFIexnbjM8355 rogid:uO+LxY/7ibIZqdd5onbfXqGAZeo9606 intact-crc:69621FD528BC097B|rigid:QBnh8YO9Yocw9/MEWGDuB+6ClGQ false binding-associated region:1718-1738(MINT-7305655) binding-associated region:88-211(MINT-7305650) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P70039 uniprotkb:O43150 intact:EBI-8069633|uniprotkb:P79934|intact:MINT-7305229 intact:EBI-310968|uniprotkb:D6W4Y8|ensembl:ENSP00000281419 psi-mi:apc_xenla(display_long)|uniprotkb:apc(gene name)|psi-mi:apc(display_short) psi-mi:asap2_human(display_long)|uniprotkb:ASAP2(gene name)|psi-mi:ASAP2(display_short)|uniprotkb:KIAA0400(gene name synonym)|uniprotkb:Pyk2 C-terminus-associated protein(gene name synonym)|uniprotkb:Paxillin-associated protein with ARF GAP activity 3(gene name synonym)|uniprotkb:DDEF2(gene name synonym)|uniprotkb:Development and differentiation-enhancing factor 2(gene name synonym) psi-mi:"MI:0077"(nuclear magnetic resonance) Matsui et al. (2008) pubmed:18786926|mint:MINT-7215866|doi:10.1074/jbc.M800420200 taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8070163|mint:MINT-7305697 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR032038|interpro:IPR009224(SAMP)|interpro:IPR026818|interpro:IPR000225(Armadillo)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR009234(APC basic)|interpro:IPR009240(APC 15 residue)|refseq:NP_001084351.1|interpro:IPR026831|interpro:IPR009223(APC cysteine-rich)|interpro:IPR009232(EB-1 binding)|interpro:IPR026836|mint:P70039|interpro:IPR036149|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000776"(kinetochore)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016477"(cell migration)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0008017"(microtubule binding)|interpro:IPR041257|mint:MINT-7305704(identity) ensembl:ENSP00000281419|ensembl:ENST00000315273|ensembl:ENSP00000316404|refseq:NP_001128663.1|refseq:NP_003878.1|ensembl:ENSG00000151693(gene)|ensembl:ENST00000281419(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0032580"(Golgi cisterna membrane)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0046872"(metal ion binding)|interpro:IPR001164(Arf GTPase activating protein)|interpro:IPR001452(Src homology-3)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002110(Ankyrin)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR020683|interpro:IPR027267|interpro:IPR035677|interpro:IPR036028|interpro:IPR036770|interpro:IPR037278|interpro:IPR037844|interpro:IPR038508|interpro:IPR043593|mint:O43150|mint:MINT-7305699(identity) - comment:mint - figure legend:f4d|comment:domino|comment:mint|partial coverage:partial coverage|curation depth:mimix curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2009/11/25 2014/10/16 rogid:yLh0z/FKIjP6FESc7rOFIexnbjM8355 rogid:Ye0xTNuPq3d3/1y/2mIFYH9ecNs9606 intact-crc:7CB50CFF1E743455|rigid:AuiV4uA3u9L8TNZEP52/+cs+UoA false binding-associated region:1718-1738(MINT-7305705) binding-associated region:944-1006(MINT-7305700) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant) uniprotkb:P70039 uniprotkb:Q9ULH1 intact:EBI-8069633|uniprotkb:P79934|intact:MINT-7305229 intact:EBI-346622|uniprotkb:B2RNV3|ensembl:ENSP00000429900 psi-mi:apc_xenla(display_long)|uniprotkb:apc(gene name)|psi-mi:apc(display_short) psi-mi:asap1_human(display_long)|uniprotkb:ASAP1(gene name)|psi-mi:ASAP1(display_short)|uniprotkb:DDEF1(gene name synonym)|uniprotkb:KIAA1249(gene name synonym)|uniprotkb:PIP2-dependent ARF1 GAP(gene name synonym)|uniprotkb:ADP-ribosylation factor-directed GTPase-activating protein 1(gene name synonym)|uniprotkb:Development and differentiation-enhancing factor 1(gene name synonym)|uniprotkb:130 kDa phosphatidylinositol 4,5-bisphosphate-dependent ARF1 GTPase-activating protein(gene name synonym)|uniprotkb:PAG2(gene name synonym) psi-mi:"MI:0077"(nuclear magnetic resonance) Matsui et al. (2008) pubmed:18786926|mint:MINT-7215866|doi:10.1074/jbc.M800420200 taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)") taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8070125|mint:MINT-7305681 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) interpro:IPR032038|interpro:IPR009224(SAMP)|interpro:IPR026818|interpro:IPR000225(Armadillo)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR009234(APC basic)|interpro:IPR009240(APC 15 residue)|refseq:NP_001084351.1|interpro:IPR026831|interpro:IPR009223(APC cysteine-rich)|interpro:IPR009232(EB-1 binding)|interpro:IPR026836|mint:P70039|interpro:IPR036149|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000776"(kinetochore)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007026"(negative regulation of microtubule depolymerization)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016477"(cell migration)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0008017"(microtubule binding)|interpro:IPR041257|mint:MINT-7305683(identity) refseq:XP_006716626.1|refseq:XP_005250982.1|refseq:NP_060952.2|ensembl:ENSP00000429900|refseq:NP_001234925.1|refseq:XP_011515354.1|rcsb pdb:2DA0|rcsb pdb:2ED1|rcsb pdb:2RQT|rcsb pdb:2RQU|reactome:R-HSA-5620916|ensembl:ENSG00000153317(gene)|ensembl:ENST00000518721(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0002102"(podosome)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005829"(cytosol)|go:"GO:0031253"(cell projection membrane)|go:"GO:0043197"(dendritic spine)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045296"(cadherin binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0060271"(cilium assembly)|go:"GO:0061000"(negative regulation of dendritic spine development)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:1903527"(positive regulation of membrane tubulation)|interpro:IPR001164(Arf GTPase activating protein)|interpro:IPR001452(Src homology-3)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002110(Ankyrin)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR020683|interpro:IPR027267|interpro:IPR036028|interpro:IPR036770|interpro:IPR037278|interpro:IPR037844|interpro:IPR037928|interpro:IPR038016|interpro:IPR038508|interpro:IPR043593|mint:Q9ULH1|rcsb pdb:2D1X|mint:MINT-7305688(identity) - comment:mint - figure legend:f4d|comment:domino|comment:mint|partial coverage:partial coverage|curation depth:mimix curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2009/11/25 2014/10/16 rogid:yLh0z/FKIjP6FESc7rOFIexnbjM8355 rogid:SNTUJDKJY1SYZwUBev1peWcNArw9606 intact-crc:3B0BC96E4F3E46AA|rigid:PyzuXZ0fS/5StwNzHOcpGsEvAYs false binding-associated region:2031-2048(MINT-7305684) binding-associated region:1067-1129(MINT-7305689) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0396"(predetermined participant)