#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:Q92556 uniprotkb:Q14185 intact:EBI-346417|uniprotkb:Q29R79|uniprotkb:Q96PB0|uniprotkb:Q9H0I1|uniprotkb:A4D1X6|uniprotkb:Q6ZTJ0|ensembl:ENSP00000312185|ensembl:ENSP00000394458|ensembl:ENSP00000406952 intact:EBI-446740|uniprotkb:A9Z1Z5|ensembl:ENSP00000280333 psi-mi:elmo1_human(display_long)|uniprotkb:ELMO1(gene name)|psi-mi:ELMO1(display_short)|uniprotkb:KIAA0281(gene name synonym)|uniprotkb:Protein ced-12 homolog(gene name synonym) psi-mi:dock1_human(display_long)|uniprotkb:180 kDa protein downstream of CRK(gene name synonym)|uniprotkb:DOCK1(gene name)|psi-mi:DOCK1(display_short) psi-mi:"MI:0096"(pull down) Komander et al. (2008) pubmed:18768751|mint:MINT-7215881|doi:10.1091/mbc.E08-04-0345 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8064190|mint:MINT-7304529 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_006715868.1|refseq:NP_569709.1|refseq:XP_005249976.1|refseq:NP_001034548.1|refseq:NP_001193409.1|refseq:NP_001193411.1|refseq:NP_055615.8|refseq:XP_011513956.1|refseq:XP_016868327.1|refseq:XP_016868328.1|dip:DIP-31095N|ensembl:ENSG00000155849(gene)|ensembl:ENST00000310758(transcript)|ensembl:ENST00000442504(transcript)|ensembl:ENST00000448602(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006915"(apoptotic process)|go:"GO:0007015"(actin filament organization)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:0048870"(cell motility)|go:"GO:0050790"(regulation of catalytic activity)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR006816(Engulfment and cell motility, ELM)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR024574|interpro:IPR030715|mint:Q92556|rcsb pdb:2RQR|rcsb pdb:2VSZ|rcsb pdb:3A98|rcsb pdb:6JPP|rcsb pdb:6TGB|rcsb pdb:6TGC|reactome:R-HSA-164944|reactome:R-HSA-2029482|reactome:R-HSA-4420097|reactome:R-HSA-8849471|reactome:R-HSA-9664422|mint:MINT-7304531(identity) ensembl:ENSP00000280333|dip:DIP-29391N|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|interpro:IPR001452(Src homology-3)|interpro:IPR010703(Dedicator of cytokinesis)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR026791|interpro:IPR027007|interpro:IPR027357|interpro:IPR032376|interpro:IPR035892|interpro:IPR036028|interpro:IPR042455|interpro:IPR043161|go:"GO:0005654"(nucleoplasm)|ensembl:ENSG00000150760(gene)|ensembl:ENST00000280333(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005096"(GTPase activator activity)|mint:Q14185|rcsb pdb:3L4C|reactome:R-HSA-2029482|reactome:R-HSA-418885|reactome:R-HSA-4420097|reactome:R-HSA-8849471|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013408|reactome:R-HSA-9664422|reactome:R-HSA-983231|interpro:IPR043162|refseq:NP_001371.1|mint:MINT-7304539(identity) - - - figure legend:f1e|comment:homomint|comment:mint|partial coverage:partial coverage|curation depth:mimix curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2009/11/25 2014/10/16 rogid:sW9Vj+Vej/oJb9qQxkbtIipDYXI9606 rogid:SsN4jN+OIbDOnPEthCF7ZdEJrdc9606 intact-crc:FDAEE674DF634E7D|rigid:d/I08nd/sTxyi98YrtfSBbxYoQc false glutathione s tranferase tag:?-?(MINT-7304536) - - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q14185 uniprotkb:Q92556 intact:EBI-446740|uniprotkb:A9Z1Z5|ensembl:ENSP00000280333 intact:EBI-346417|uniprotkb:Q29R79|uniprotkb:Q96PB0|uniprotkb:Q9H0I1|uniprotkb:A4D1X6|uniprotkb:Q6ZTJ0|ensembl:ENSP00000312185|ensembl:ENSP00000394458|ensembl:ENSP00000406952 psi-mi:dock1_human(display_long)|uniprotkb:180 kDa protein downstream of CRK(gene name synonym)|uniprotkb:DOCK1(gene name)|psi-mi:DOCK1(display_short) psi-mi:elmo1_human(display_long)|uniprotkb:ELMO1(gene name)|psi-mi:ELMO1(display_short)|uniprotkb:KIAA0281(gene name synonym)|uniprotkb:Protein ced-12 homolog(gene name synonym) psi-mi:"MI:0096"(pull down) Komander et al. (2008) pubmed:18768751|mint:MINT-7215881|doi:10.1091/mbc.E08-04-0345 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8064169|mint:MINT-7304464 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000280333|dip:DIP-29391N|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|interpro:IPR001452(Src homology-3)|interpro:IPR010703(Dedicator of cytokinesis)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR026791|interpro:IPR027007|interpro:IPR027357|interpro:IPR032376|interpro:IPR035892|interpro:IPR036028|interpro:IPR042455|interpro:IPR043161|go:"GO:0005654"(nucleoplasm)|ensembl:ENSG00000150760(gene)|ensembl:ENST00000280333(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005096"(GTPase activator activity)|mint:Q14185|rcsb pdb:3L4C|reactome:R-HSA-2029482|reactome:R-HSA-418885|reactome:R-HSA-4420097|reactome:R-HSA-8849471|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013408|reactome:R-HSA-9664422|reactome:R-HSA-983231|interpro:IPR043162|refseq:NP_001371.1|mint:MINT-7304466(identity) refseq:XP_006715868.1|refseq:NP_569709.1|refseq:XP_005249976.1|refseq:NP_001034548.1|refseq:NP_001193409.1|refseq:NP_001193411.1|refseq:NP_055615.8|refseq:XP_011513956.1|refseq:XP_016868327.1|refseq:XP_016868328.1|dip:DIP-31095N|ensembl:ENSG00000155849(gene)|ensembl:ENST00000310758(transcript)|ensembl:ENST00000442504(transcript)|ensembl:ENST00000448602(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006915"(apoptotic process)|go:"GO:0007015"(actin filament organization)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:0048870"(cell motility)|go:"GO:0050790"(regulation of catalytic activity)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR006816(Engulfment and cell motility, ELM)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR024574|interpro:IPR030715|mint:Q92556|rcsb pdb:2RQR|rcsb pdb:2VSZ|rcsb pdb:3A98|rcsb pdb:6JPP|rcsb pdb:6TGB|rcsb pdb:6TGC|reactome:R-HSA-164944|reactome:R-HSA-2029482|reactome:R-HSA-4420097|reactome:R-HSA-8849471|reactome:R-HSA-9664422|mint:MINT-7304467(identity) - - - figure legend:f1b|comment:homomint|comment:domino|comment:mint|partial coverage:partial coverage|curation depth:mimix curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2009/11/25 2014/10/16 rogid:SsN4jN+OIbDOnPEthCF7ZdEJrdc9606 rogid:sW9Vj+Vej/oJb9qQxkbtIipDYXI9606 intact-crc:3EF32B9404CE6D6A|rigid:d/I08nd/sTxyi98YrtfSBbxYoQc false - binding-associated region:532-707(IPR001849)|glutathione s tranferase tag:?-?(MINT-7304481) - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q14185 uniprotkb:Q92556 intact:EBI-446740|uniprotkb:A9Z1Z5|ensembl:ENSP00000280333 intact:EBI-346417|uniprotkb:Q29R79|uniprotkb:Q96PB0|uniprotkb:Q9H0I1|uniprotkb:A4D1X6|uniprotkb:Q6ZTJ0|ensembl:ENSP00000312185|ensembl:ENSP00000394458|ensembl:ENSP00000406952 psi-mi:dock1_human(display_long)|uniprotkb:180 kDa protein downstream of CRK(gene name synonym)|uniprotkb:DOCK1(gene name)|psi-mi:DOCK1(display_short) psi-mi:elmo1_human(display_long)|uniprotkb:ELMO1(gene name)|psi-mi:ELMO1(display_short)|uniprotkb:KIAA0281(gene name synonym)|uniprotkb:Protein ced-12 homolog(gene name synonym) psi-mi:"MI:0096"(pull down) Komander et al. (2008) pubmed:18768751|mint:MINT-7215881|doi:10.1091/mbc.E08-04-0345 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8064205|mint:MINT-7304644 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000280333|dip:DIP-29391N|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|interpro:IPR001452(Src homology-3)|interpro:IPR010703(Dedicator of cytokinesis)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR026791|interpro:IPR027007|interpro:IPR027357|interpro:IPR032376|interpro:IPR035892|interpro:IPR036028|interpro:IPR042455|interpro:IPR043161|go:"GO:0005654"(nucleoplasm)|ensembl:ENSG00000150760(gene)|ensembl:ENST00000280333(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005096"(GTPase activator activity)|mint:Q14185|rcsb pdb:3L4C|reactome:R-HSA-2029482|reactome:R-HSA-418885|reactome:R-HSA-4420097|reactome:R-HSA-8849471|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013408|reactome:R-HSA-9664422|reactome:R-HSA-983231|interpro:IPR043162|refseq:NP_001371.1|mint:MINT-7304662(identity) refseq:XP_006715868.1|refseq:NP_569709.1|refseq:XP_005249976.1|refseq:NP_001034548.1|refseq:NP_001193409.1|refseq:NP_001193411.1|refseq:NP_055615.8|refseq:XP_011513956.1|refseq:XP_016868327.1|refseq:XP_016868328.1|dip:DIP-31095N|ensembl:ENSG00000155849(gene)|ensembl:ENST00000310758(transcript)|ensembl:ENST00000442504(transcript)|ensembl:ENST00000448602(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006915"(apoptotic process)|go:"GO:0007015"(actin filament organization)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:0048870"(cell motility)|go:"GO:0050790"(regulation of catalytic activity)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR006816(Engulfment and cell motility, ELM)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR024574|interpro:IPR030715|mint:Q92556|rcsb pdb:2RQR|rcsb pdb:2VSZ|rcsb pdb:3A98|rcsb pdb:6JPP|rcsb pdb:6TGB|rcsb pdb:6TGC|reactome:R-HSA-164944|reactome:R-HSA-2029482|reactome:R-HSA-4420097|reactome:R-HSA-8849471|reactome:R-HSA-9664422|mint:MINT-7304646(identity) - - - figure legend:f4e|comment:homomint|comment:mint|partial coverage:partial coverage|curation depth:mimix curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2009/11/25 2014/10/16 rogid:SsN4jN+OIbDOnPEthCF7ZdEJrdc9606 rogid:sW9Vj+Vej/oJb9qQxkbtIipDYXI9606 intact-crc:D1240F8E722063A2|rigid:d/I08nd/sTxyi98YrtfSBbxYoQc false flag tag:?-?(MINT-7304663) glutathione s tranferase tag:?-?(MINT-7304657)|mutation disrupting interaction:544-544(MINT-7304653)|mutation disrupting interaction:548-548(MINT-7304647)|mutation disrupting interaction:545-545(MINT-7304651)|mutation disrupting interaction:547-547(MINT-7304649)|binding-associated region:534-558(MINT-7304659)|mutation disrupting interaction:536-536(MINT-7304655) - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q92556 uniprotkb:Q14185 intact:EBI-346417|uniprotkb:Q29R79|uniprotkb:Q96PB0|uniprotkb:Q9H0I1|uniprotkb:A4D1X6|uniprotkb:Q6ZTJ0|ensembl:ENSP00000312185|ensembl:ENSP00000394458|ensembl:ENSP00000406952 intact:EBI-446740|uniprotkb:A9Z1Z5|ensembl:ENSP00000280333 psi-mi:elmo1_human(display_long)|uniprotkb:ELMO1(gene name)|psi-mi:ELMO1(display_short)|uniprotkb:KIAA0281(gene name synonym)|uniprotkb:Protein ced-12 homolog(gene name synonym) psi-mi:dock1_human(display_long)|uniprotkb:180 kDa protein downstream of CRK(gene name synonym)|uniprotkb:DOCK1(gene name)|psi-mi:DOCK1(display_short) psi-mi:"MI:0096"(pull down) Komander et al. (2008) pubmed:18768751|mint:MINT-7215881|doi:10.1091/mbc.E08-04-0345 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8064355|mint:MINT-7304751 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_006715868.1|refseq:NP_569709.1|refseq:XP_005249976.1|refseq:NP_001034548.1|refseq:NP_001193409.1|refseq:NP_001193411.1|refseq:NP_055615.8|refseq:XP_011513956.1|refseq:XP_016868327.1|refseq:XP_016868328.1|dip:DIP-31095N|ensembl:ENSG00000155849(gene)|ensembl:ENST00000310758(transcript)|ensembl:ENST00000442504(transcript)|ensembl:ENST00000448602(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006915"(apoptotic process)|go:"GO:0007015"(actin filament organization)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:0048870"(cell motility)|go:"GO:0050790"(regulation of catalytic activity)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR006816(Engulfment and cell motility, ELM)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR024574|interpro:IPR030715|mint:Q92556|rcsb pdb:2RQR|rcsb pdb:2VSZ|rcsb pdb:3A98|rcsb pdb:6JPP|rcsb pdb:6TGB|rcsb pdb:6TGC|reactome:R-HSA-164944|reactome:R-HSA-2029482|reactome:R-HSA-4420097|reactome:R-HSA-8849471|reactome:R-HSA-9664422|mint:MINT-7304762(identity) ensembl:ENSP00000280333|dip:DIP-29391N|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|interpro:IPR001452(Src homology-3)|interpro:IPR010703(Dedicator of cytokinesis)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR026791|interpro:IPR027007|interpro:IPR027357|interpro:IPR032376|interpro:IPR035892|interpro:IPR036028|interpro:IPR042455|interpro:IPR043161|go:"GO:0005654"(nucleoplasm)|ensembl:ENSG00000150760(gene)|ensembl:ENST00000280333(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005096"(GTPase activator activity)|mint:Q14185|rcsb pdb:3L4C|reactome:R-HSA-2029482|reactome:R-HSA-418885|reactome:R-HSA-4420097|reactome:R-HSA-8849471|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013408|reactome:R-HSA-9664422|reactome:R-HSA-983231|interpro:IPR043162|refseq:NP_001371.1|mint:MINT-7304753(identity) - - - comment:homomint|figure legend:f5e|comment:domino|comment:mint|partial coverage:partial coverage|curation depth:mimix curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2009/11/25 2014/10/16 rogid:sW9Vj+Vej/oJb9qQxkbtIipDYXI9606 rogid:SsN4jN+OIbDOnPEthCF7ZdEJrdc9606 intact-crc:A7AC72C64FA5C276|rigid:d/I08nd/sTxyi98YrtfSBbxYoQc false glutathione s tranferase tag:?-?(MINT-7304763) binding-associated region:1-187(MINT-7304756)|flag tag:?-?(MINT-7304759) - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q14185 uniprotkb:Q92556 intact:EBI-446740|uniprotkb:A9Z1Z5|ensembl:ENSP00000280333 intact:EBI-346417|uniprotkb:Q29R79|uniprotkb:Q96PB0|uniprotkb:Q9H0I1|uniprotkb:A4D1X6|uniprotkb:Q6ZTJ0|ensembl:ENSP00000312185|ensembl:ENSP00000394458|ensembl:ENSP00000406952 psi-mi:dock1_human(display_long)|uniprotkb:180 kDa protein downstream of CRK(gene name synonym)|uniprotkb:DOCK1(gene name)|psi-mi:DOCK1(display_short) psi-mi:elmo1_human(display_long)|uniprotkb:ELMO1(gene name)|psi-mi:ELMO1(display_short)|uniprotkb:KIAA0281(gene name synonym)|uniprotkb:Protein ced-12 homolog(gene name synonym) psi-mi:"MI:0096"(pull down) Komander et al. (2008) pubmed:18768751|mint:MINT-7215881|doi:10.1091/mbc.E08-04-0345 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8064328|mint:MINT-7304698 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000280333|dip:DIP-29391N|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|interpro:IPR001452(Src homology-3)|interpro:IPR010703(Dedicator of cytokinesis)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR026791|interpro:IPR027007|interpro:IPR027357|interpro:IPR032376|interpro:IPR035892|interpro:IPR036028|interpro:IPR042455|interpro:IPR043161|go:"GO:0005654"(nucleoplasm)|ensembl:ENSG00000150760(gene)|ensembl:ENST00000280333(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005096"(GTPase activator activity)|mint:Q14185|rcsb pdb:3L4C|reactome:R-HSA-2029482|reactome:R-HSA-418885|reactome:R-HSA-4420097|reactome:R-HSA-8849471|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013408|reactome:R-HSA-9664422|reactome:R-HSA-983231|interpro:IPR043162|refseq:NP_001371.1|mint:MINT-7304708(identity) refseq:XP_006715868.1|refseq:NP_569709.1|refseq:XP_005249976.1|refseq:NP_001034548.1|refseq:NP_001193409.1|refseq:NP_001193411.1|refseq:NP_055615.8|refseq:XP_011513956.1|refseq:XP_016868327.1|refseq:XP_016868328.1|dip:DIP-31095N|ensembl:ENSG00000155849(gene)|ensembl:ENST00000310758(transcript)|ensembl:ENST00000442504(transcript)|ensembl:ENST00000448602(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006915"(apoptotic process)|go:"GO:0007015"(actin filament organization)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:0048870"(cell motility)|go:"GO:0050790"(regulation of catalytic activity)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR006816(Engulfment and cell motility, ELM)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR024574|interpro:IPR030715|mint:Q92556|rcsb pdb:2RQR|rcsb pdb:2VSZ|rcsb pdb:3A98|rcsb pdb:6JPP|rcsb pdb:6TGB|rcsb pdb:6TGC|reactome:R-HSA-164944|reactome:R-HSA-2029482|reactome:R-HSA-4420097|reactome:R-HSA-8849471|reactome:R-HSA-9664422|mint:MINT-7304700(identity) - - - comment:homomint|comment:domino|comment:mint|figure legend:f5c f5d f5g|partial coverage:partial coverage|curation depth:mimix curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2009/11/25 2014/10/16 rogid:SsN4jN+OIbDOnPEthCF7ZdEJrdc9606 rogid:sW9Vj+Vej/oJb9qQxkbtIipDYXI9606 intact-crc:B7081C39A016606F|rigid:d/I08nd/sTxyi98YrtfSBbxYoQc false glutathione s tranferase tag:?-?(MINT-7304712)|mutation decreasing interaction:45-45(MINT-7304717)|binding-associated region:1-200(MINT-7304714) myc tag:?-?(MINT-7304705) - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q92556 uniprotkb:Q14185 intact:EBI-346417|uniprotkb:Q29R79|uniprotkb:Q96PB0|uniprotkb:Q9H0I1|uniprotkb:A4D1X6|uniprotkb:Q6ZTJ0|ensembl:ENSP00000312185|ensembl:ENSP00000394458|ensembl:ENSP00000406952 intact:EBI-446740|uniprotkb:A9Z1Z5|ensembl:ENSP00000280333 psi-mi:elmo1_human(display_long)|uniprotkb:ELMO1(gene name)|psi-mi:ELMO1(display_short)|uniprotkb:KIAA0281(gene name synonym)|uniprotkb:Protein ced-12 homolog(gene name synonym) psi-mi:dock1_human(display_long)|uniprotkb:180 kDa protein downstream of CRK(gene name synonym)|uniprotkb:DOCK1(gene name)|psi-mi:DOCK1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Komander et al. (2008) pubmed:18768751|mint:MINT-7215881|doi:10.1091/mbc.E08-04-0345 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8064390|mint:MINT-7304510 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_006715868.1|refseq:NP_569709.1|refseq:XP_005249976.1|refseq:NP_001034548.1|refseq:NP_001193409.1|refseq:NP_001193411.1|refseq:NP_055615.8|refseq:XP_011513956.1|refseq:XP_016868327.1|refseq:XP_016868328.1|dip:DIP-31095N|ensembl:ENSG00000155849(gene)|ensembl:ENST00000310758(transcript)|ensembl:ENST00000442504(transcript)|ensembl:ENST00000448602(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006915"(apoptotic process)|go:"GO:0007015"(actin filament organization)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:0048870"(cell motility)|go:"GO:0050790"(regulation of catalytic activity)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR006816(Engulfment and cell motility, ELM)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR024574|interpro:IPR030715|mint:Q92556|rcsb pdb:2RQR|rcsb pdb:2VSZ|rcsb pdb:3A98|rcsb pdb:6JPP|rcsb pdb:6TGB|rcsb pdb:6TGC|reactome:R-HSA-164944|reactome:R-HSA-2029482|reactome:R-HSA-4420097|reactome:R-HSA-8849471|reactome:R-HSA-9664422|mint:MINT-7304516(identity) ensembl:ENSP00000280333|dip:DIP-29391N|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|interpro:IPR001452(Src homology-3)|interpro:IPR010703(Dedicator of cytokinesis)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR026791|interpro:IPR027007|interpro:IPR027357|interpro:IPR032376|interpro:IPR035892|interpro:IPR036028|interpro:IPR042455|interpro:IPR043161|go:"GO:0005654"(nucleoplasm)|ensembl:ENSG00000150760(gene)|ensembl:ENST00000280333(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005096"(GTPase activator activity)|mint:Q14185|rcsb pdb:3L4C|reactome:R-HSA-2029482|reactome:R-HSA-418885|reactome:R-HSA-4420097|reactome:R-HSA-8849471|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013408|reactome:R-HSA-9664422|reactome:R-HSA-983231|interpro:IPR043162|refseq:NP_001371.1|mint:MINT-7304512(identity) - - - figure legend:f1d|comment:homomint|comment:mint|partial coverage:partial coverage|curation depth:mimix curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2009/11/25 2014/10/16 rogid:sW9Vj+Vej/oJb9qQxkbtIipDYXI9606 rogid:SsN4jN+OIbDOnPEthCF7ZdEJrdc9606 intact-crc:98BBCFD1BE0ECD48|rigid:d/I08nd/sTxyi98YrtfSBbxYoQc false myc tag:?-?(MINT-7304517) - - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0113"(western blot) uniprotkb:Q14185 uniprotkb:Q92556 intact:EBI-446740|uniprotkb:A9Z1Z5|ensembl:ENSP00000280333 intact:EBI-346417|uniprotkb:Q29R79|uniprotkb:Q96PB0|uniprotkb:Q9H0I1|uniprotkb:A4D1X6|uniprotkb:Q6ZTJ0|ensembl:ENSP00000312185|ensembl:ENSP00000394458|ensembl:ENSP00000406952 psi-mi:dock1_human(display_long)|uniprotkb:180 kDa protein downstream of CRK(gene name synonym)|uniprotkb:DOCK1(gene name)|psi-mi:DOCK1(display_short) psi-mi:elmo1_human(display_long)|uniprotkb:ELMO1(gene name)|psi-mi:ELMO1(display_short)|uniprotkb:KIAA0281(gene name synonym)|uniprotkb:Protein ced-12 homolog(gene name synonym) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Komander et al. (2008) pubmed:18768751|mint:MINT-7215881|doi:10.1091/mbc.E08-04-0345 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8064470|mint:MINT-7304722 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000280333|dip:DIP-29391N|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|interpro:IPR001452(Src homology-3)|interpro:IPR010703(Dedicator of cytokinesis)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR026791|interpro:IPR027007|interpro:IPR027357|interpro:IPR032376|interpro:IPR035892|interpro:IPR036028|interpro:IPR042455|interpro:IPR043161|go:"GO:0005654"(nucleoplasm)|ensembl:ENSG00000150760(gene)|ensembl:ENST00000280333(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005096"(GTPase activator activity)|mint:Q14185|rcsb pdb:3L4C|reactome:R-HSA-2029482|reactome:R-HSA-418885|reactome:R-HSA-4420097|reactome:R-HSA-8849471|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013408|reactome:R-HSA-9664422|reactome:R-HSA-983231|interpro:IPR043162|refseq:NP_001371.1|mint:MINT-7304724(identity) refseq:XP_006715868.1|refseq:NP_569709.1|refseq:XP_005249976.1|refseq:NP_001034548.1|refseq:NP_001193409.1|refseq:NP_001193411.1|refseq:NP_055615.8|refseq:XP_011513956.1|refseq:XP_016868327.1|refseq:XP_016868328.1|dip:DIP-31095N|ensembl:ENSG00000155849(gene)|ensembl:ENST00000310758(transcript)|ensembl:ENST00000442504(transcript)|ensembl:ENST00000448602(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006915"(apoptotic process)|go:"GO:0007015"(actin filament organization)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:0048870"(cell motility)|go:"GO:0050790"(regulation of catalytic activity)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR006816(Engulfment and cell motility, ELM)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR024574|interpro:IPR030715|mint:Q92556|rcsb pdb:2RQR|rcsb pdb:2VSZ|rcsb pdb:3A98|rcsb pdb:6JPP|rcsb pdb:6TGB|rcsb pdb:6TGC|reactome:R-HSA-164944|reactome:R-HSA-2029482|reactome:R-HSA-4420097|reactome:R-HSA-8849471|reactome:R-HSA-9664422|mint:MINT-7304733(identity) - - - figure legend:f5b|comment:homomint|comment:mint|partial coverage:partial coverage|curation depth:mimix curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2009/11/25 2014/10/16 rogid:SsN4jN+OIbDOnPEthCF7ZdEJrdc9606 rogid:sW9Vj+Vej/oJb9qQxkbtIipDYXI9606 intact-crc:16B7A6F9009FC97A|rigid:d/I08nd/sTxyi98YrtfSBbxYoQc false binding-associated region:1-535(MINT-7304727) myc tag:?-?(MINT-7304734) - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q92556 uniprotkb:Q14185 intact:EBI-346417|uniprotkb:Q29R79|uniprotkb:Q96PB0|uniprotkb:Q9H0I1|uniprotkb:A4D1X6|uniprotkb:Q6ZTJ0|ensembl:ENSP00000312185|ensembl:ENSP00000394458|ensembl:ENSP00000406952 intact:EBI-446740|uniprotkb:A9Z1Z5|ensembl:ENSP00000280333 psi-mi:elmo1_human(display_long)|uniprotkb:ELMO1(gene name)|psi-mi:ELMO1(display_short)|uniprotkb:KIAA0281(gene name synonym)|uniprotkb:Protein ced-12 homolog(gene name synonym) psi-mi:dock1_human(display_long)|uniprotkb:180 kDa protein downstream of CRK(gene name synonym)|uniprotkb:DOCK1(gene name)|psi-mi:DOCK1(display_short) psi-mi:"MI:0007"(anti tag coimmunoprecipitation) Komander et al. (2008) pubmed:18768751|mint:MINT-7215881|doi:10.1091/mbc.E08-04-0345 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8064429|mint:MINT-7304545 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) refseq:XP_006715868.1|refseq:NP_569709.1|refseq:XP_005249976.1|refseq:NP_001034548.1|refseq:NP_001193409.1|refseq:NP_001193411.1|refseq:NP_055615.8|refseq:XP_011513956.1|refseq:XP_016868327.1|refseq:XP_016868328.1|dip:DIP-31095N|ensembl:ENSG00000155849(gene)|ensembl:ENST00000310758(transcript)|ensembl:ENST00000442504(transcript)|ensembl:ENST00000448602(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006915"(apoptotic process)|go:"GO:0007015"(actin filament organization)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:0048870"(cell motility)|go:"GO:0050790"(regulation of catalytic activity)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR006816(Engulfment and cell motility, ELM)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR024574|interpro:IPR030715|mint:Q92556|rcsb pdb:2RQR|rcsb pdb:2VSZ|rcsb pdb:3A98|rcsb pdb:6JPP|rcsb pdb:6TGB|rcsb pdb:6TGC|reactome:R-HSA-164944|reactome:R-HSA-2029482|reactome:R-HSA-4420097|reactome:R-HSA-8849471|reactome:R-HSA-9664422|mint:MINT-7304549(identity) ensembl:ENSP00000280333|dip:DIP-29391N|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|interpro:IPR001452(Src homology-3)|interpro:IPR010703(Dedicator of cytokinesis)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR026791|interpro:IPR027007|interpro:IPR027357|interpro:IPR032376|interpro:IPR035892|interpro:IPR036028|interpro:IPR042455|interpro:IPR043161|go:"GO:0005654"(nucleoplasm)|ensembl:ENSG00000150760(gene)|ensembl:ENST00000280333(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005096"(GTPase activator activity)|mint:Q14185|rcsb pdb:3L4C|reactome:R-HSA-2029482|reactome:R-HSA-418885|reactome:R-HSA-4420097|reactome:R-HSA-8849471|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013408|reactome:R-HSA-9664422|reactome:R-HSA-983231|interpro:IPR043162|refseq:NP_001371.1|mint:MINT-7304547(identity) - - - figure legend:f4d|comment:homomint|comment:mint|partial coverage:partial coverage|curation depth:mimix curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2009/11/25 2014/10/16 rogid:sW9Vj+Vej/oJb9qQxkbtIipDYXI9606 rogid:SsN4jN+OIbDOnPEthCF7ZdEJrdc9606 intact-crc:EE8CDDEE7320BD7E|rigid:d/I08nd/sTxyi98YrtfSBbxYoQc false mutation disrupting interaction:544-544(MINT-7304628)|mutation disrupting interaction:545-545(MINT-7304631)|binding-associated region:534-558(MINT-7304623)|mutation disrupting interaction:536-536(MINT-7304625)|mutation disrupting interaction:548-548(MINT-7304637)|mutation disrupting interaction:547-547(MINT-7304634)|myc tag:?-?(MINT-7304550) flag tag:?-?(MINT-7304641) - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q14185 uniprotkb:Q92556 intact:EBI-446740|uniprotkb:A9Z1Z5|ensembl:ENSP00000280333 intact:EBI-346417|uniprotkb:Q29R79|uniprotkb:Q96PB0|uniprotkb:Q9H0I1|uniprotkb:A4D1X6|uniprotkb:Q6ZTJ0|ensembl:ENSP00000312185|ensembl:ENSP00000394458|ensembl:ENSP00000406952 psi-mi:dock1_human(display_long)|uniprotkb:180 kDa protein downstream of CRK(gene name synonym)|uniprotkb:DOCK1(gene name)|psi-mi:DOCK1(display_short) psi-mi:elmo1_human(display_long)|uniprotkb:ELMO1(gene name)|psi-mi:ELMO1(display_short)|uniprotkb:KIAA0281(gene name synonym)|uniprotkb:Protein ced-12 homolog(gene name synonym) psi-mi:"MI:0006"(anti bait coimmunoprecipitation) Komander et al. (2008) pubmed:18768751|mint:MINT-7215881|doi:10.1091/mbc.E08-04-0345 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-8064517|mint:MINT-7304491 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSP00000280333|dip:DIP-29391N|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|interpro:IPR001452(Src homology-3)|interpro:IPR010703(Dedicator of cytokinesis)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR026791|interpro:IPR027007|interpro:IPR027357|interpro:IPR032376|interpro:IPR035892|interpro:IPR036028|interpro:IPR042455|interpro:IPR043161|go:"GO:0005654"(nucleoplasm)|ensembl:ENSG00000150760(gene)|ensembl:ENST00000280333(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005096"(GTPase activator activity)|mint:Q14185|rcsb pdb:3L4C|reactome:R-HSA-2029482|reactome:R-HSA-418885|reactome:R-HSA-4420097|reactome:R-HSA-8849471|reactome:R-HSA-9013149|reactome:R-HSA-9013404|reactome:R-HSA-9013408|reactome:R-HSA-9664422|reactome:R-HSA-983231|interpro:IPR043162|refseq:NP_001371.1|mint:MINT-7304501(identity) refseq:XP_006715868.1|refseq:NP_569709.1|refseq:XP_005249976.1|refseq:NP_001034548.1|refseq:NP_001193409.1|refseq:NP_001193411.1|refseq:NP_055615.8|refseq:XP_011513956.1|refseq:XP_016868327.1|refseq:XP_016868328.1|dip:DIP-31095N|ensembl:ENSG00000155849(gene)|ensembl:ENST00000310758(transcript)|ensembl:ENST00000442504(transcript)|ensembl:ENST00000448602(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006915"(apoptotic process)|go:"GO:0007015"(actin filament organization)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:0048870"(cell motility)|go:"GO:0050790"(regulation of catalytic activity)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR006816(Engulfment and cell motility, ELM)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR024574|interpro:IPR030715|mint:Q92556|rcsb pdb:2RQR|rcsb pdb:2VSZ|rcsb pdb:3A98|rcsb pdb:6JPP|rcsb pdb:6TGB|rcsb pdb:6TGC|reactome:R-HSA-164944|reactome:R-HSA-2029482|reactome:R-HSA-4420097|reactome:R-HSA-8849471|reactome:R-HSA-9664422|mint:MINT-7304493(identity) - - - figure legend:f1c|comment:homomint|comment:domino|comment:mint|partial coverage:partial coverage|curation depth:mimix curation taxid:9606(human-293)|taxid:9606(Homo sapiens transformed primary embryonal kidney cells) - 2009/11/25 2014/10/16 rogid:SsN4jN+OIbDOnPEthCF7ZdEJrdc9606 rogid:sW9Vj+Vej/oJb9qQxkbtIipDYXI9606 intact-crc:33717C67F06A2337|rigid:d/I08nd/sTxyi98YrtfSBbxYoQc false flag tag:?-?(MINT-7304506) binding-associated region:532-707(IPR001849)|green fluorescent protein tag:?-?(MINT-7304498) - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0705"(anti tag western blot)