#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q8TE68	uniprotkb:P07766	intact:EBI-7487998|uniprotkb:Q9GZQ2|uniprotkb:Q9NXH0|intact:MINT-4829629|uniprotkb:Q9BSQ2|uniprotkb:Q8NC10|uniprotkb:Q96BB7|uniprotkb:Q71RE2|ensembl:ENSP00000201647	intact:EBI-1211297|uniprotkb:A8K997|intact:EBI-28973315|ensembl:ENSP00000354566	psi-mi:es8l1_human(display_long)|uniprotkb:EPS8L1(gene name)|psi-mi:EPS8L1(display_short)|uniprotkb:DRC3(gene name synonym)|uniprotkb:EPS8R1(gene name synonym)|uniprotkb:PP10566(orf name)|uniprotkb:Epidermal growth factor receptor pathway substrate 8-related protein 1(gene name synonym)	psi-mi:cd3e_human(display_long)|uniprotkb:CD3E(gene name)|psi-mi:CD3E(display_short)|uniprotkb:T3E(gene name synonym)|uniprotkb:T-cell surface antigen T3/Leu-4 epsilon chain(gene name synonym)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Aitio et al. (2008)	pubmed:18644376|mint:MINT-7215950|doi:10.1016/j.jmb.2008.07.008	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8027813|mint:MINT-7218473	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_573441.2|refseq:NP_060199.3|ensembl:ENSG00000131037(gene)|ensembl:ENST00000201647(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0042608"(T cell receptor binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:1900029"(positive regulation of ruffle assembly)|interpro:IPR001452(Src homology-3)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013625(Tensin phosphotyrosine-binding domain)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR033928|interpro:IPR035462|interpro:IPR036028|interpro:IPR039801|interpro:IPR041418|mint:Q8TE68|rcsb pdb:2K2M|rcsb pdb:2ROL|mint:MINT-7218476(identity)	refseq:NP_000724.1|ensembl:ENSP00000354566|ensembl:ENSG00000198851(gene)|ensembl:ENST00000361763(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002669"(positive regulation of T cell anergy)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007584"(response to nutrient)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0031295"(T cell costimulation)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0033634"(positive regulation of cell-cell adhesion mediated by integrin)|go:"GO:0042101"(T cell receptor complex)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042105"(alpha-beta T cell receptor complex)|go:"GO:0042110"(T cell activation)|go:"GO:0042608"(T cell receptor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0044297"(cell body)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0046641"(positive regulation of alpha-beta T cell proliferation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0097190"(apoptotic signaling pathway)|interpro:IPR003110(Phosphorylated immunoreceptor signaling ITAM)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015484(CD3 gamma and delta chain)|interpro:IPR036179|mint:P07766|rcsb pdb:1A81|rcsb pdb:1SY6|rcsb pdb:1XIW|rcsb pdb:2ROL|rcsb pdb:5QU2|rcsb pdb:6JXR|reactome:R-HSA-198933|reactome:R-HSA-202424|reactome:R-HSA-202427|reactome:R-HSA-202430|reactome:R-HSA-202433|reactome:R-HSA-389948|mint:MINT-7218475(identity)	-	comment:mint|function:Stimulates guanine exchange activity of SOS1. May play a role in membrane ruffling and remodeling of the actin cytoskeleton	-	comment:homomint|comment:domino|comment:mint|figure legend:t1 f2  f4 f6|curation depth:mimix curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/07/13	2014/10/16	rogid:+6FNaPhLMckwu8jRsJiBKKWYYOI9606	rogid:9BgUsAHGr15di4bpGeW9UjdzWlE9606	intact-crc:70612B375E7288E1|rigid:5HGMHf6qePTcHPSuV+rkjIOvST4	false	binding-associated region:478-537(MINT-7218480)	binding-associated region:181-191(MINT-7218485)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8TE68	uniprotkb:P07766	intact:EBI-7487998|uniprotkb:Q9GZQ2|uniprotkb:Q9NXH0|intact:MINT-4829629|uniprotkb:Q9BSQ2|uniprotkb:Q8NC10|uniprotkb:Q96BB7|uniprotkb:Q71RE2|ensembl:ENSP00000201647	intact:EBI-1211297|uniprotkb:A8K997|intact:EBI-28973315|ensembl:ENSP00000354566	psi-mi:es8l1_human(display_long)|uniprotkb:EPS8L1(gene name)|psi-mi:EPS8L1(display_short)|uniprotkb:DRC3(gene name synonym)|uniprotkb:EPS8R1(gene name synonym)|uniprotkb:PP10566(orf name)|uniprotkb:Epidermal growth factor receptor pathway substrate 8-related protein 1(gene name synonym)	psi-mi:cd3e_human(display_long)|uniprotkb:CD3E(gene name)|psi-mi:CD3E(display_short)|uniprotkb:T3E(gene name synonym)|uniprotkb:T-cell surface antigen T3/Leu-4 epsilon chain(gene name synonym)	psi-mi:"MI:0065"(isothermal titration calorimetry)	Aitio et al. (2008)	pubmed:18644376|mint:MINT-7215950|doi:10.1016/j.jmb.2008.07.008	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-8027862|mint:MINT-7218489	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_573441.2|refseq:NP_060199.3|ensembl:ENSG00000131037(gene)|ensembl:ENST00000201647(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0042608"(T cell receptor binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:1900029"(positive regulation of ruffle assembly)|interpro:IPR001452(Src homology-3)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR013625(Tensin phosphotyrosine-binding domain)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR033928|interpro:IPR035462|interpro:IPR036028|interpro:IPR039801|interpro:IPR041418|mint:Q8TE68|rcsb pdb:2K2M|rcsb pdb:2ROL|mint:MINT-7218491(identity)	refseq:NP_000724.1|ensembl:ENSP00000354566|ensembl:ENSG00000198851(gene)|ensembl:ENST00000361763(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002669"(positive regulation of T cell anergy)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007584"(response to nutrient)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016358"(dendrite development)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0031295"(T cell costimulation)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0033634"(positive regulation of cell-cell adhesion mediated by integrin)|go:"GO:0042101"(T cell receptor complex)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042105"(alpha-beta T cell receptor complex)|go:"GO:0042110"(T cell activation)|go:"GO:0042608"(T cell receptor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0044297"(cell body)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0046641"(positive regulation of alpha-beta T cell proliferation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0097190"(apoptotic signaling pathway)|interpro:IPR003110(Phosphorylated immunoreceptor signaling ITAM)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015484(CD3 gamma and delta chain)|interpro:IPR036179|mint:P07766|rcsb pdb:1A81|rcsb pdb:1SY6|rcsb pdb:1XIW|rcsb pdb:2ROL|rcsb pdb:5QU2|rcsb pdb:6JXR|reactome:R-HSA-198933|reactome:R-HSA-202424|reactome:R-HSA-202427|reactome:R-HSA-202430|reactome:R-HSA-202433|reactome:R-HSA-389948|mint:MINT-7218496(identity)	-	comment:mint|function:Stimulates guanine exchange activity of SOS1. May play a role in membrane ruffling and remodeling of the actin cytoskeleton	-	figure legend:f3|comment:homomint|comment:domino|comment:mint|curation depth:mimix curation	taxid:-1(in vitro)|taxid:-1(In vitro)	kd:24.0x10^-6(molar)	2009/07/13	2014/10/16	rogid:+6FNaPhLMckwu8jRsJiBKKWYYOI9606	rogid:9BgUsAHGr15di4bpGeW9UjdzWlE9606	intact-crc:1B8ED05BEF5B6C0C|rigid:5HGMHf6qePTcHPSuV+rkjIOvST4	false	binding-associated region:478-537(MINT-7218492)	binding-associated region:181-191(MINT-7218497)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)