#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P36412	uniprotkb:Q54IZ7	intact:EBI-8025515|uniprotkb:Q55CC4|intact:MINT-6947977|ensemblprotists:EAL71969	intact:EBI-8025538|intact:MINT-6947817	psi-mi:rb11a_dicdi(display_long)|uniprotkb:rab11A(gene name)|psi-mi:rab11A(display_short)|uniprotkb:rab11(gene name synonym)|uniprotkb:DDB_G0269238(orf name)	psi-mi:q54iz7_dicdi(display_long)|uniprotkb:DDB0187927(orf name)	psi-mi:"MI:0416"(fluorescence microscopy)	Du et al. (2008)	pubmed:18636095|imex:IM-11658|mint:MINT-6947792|doi:10.1038/emboj.2008.131	taxid:44689(dicdi)|taxid:44689("Dictyostelium discoideum (Slime mold)")	taxid:44689(dicdi)|taxid:44689("Dictyostelium discoideum (Slime mold)")	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-8025564|mint:MINT-6947830|imex:IM-11658-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dictybase:DDB_G0269238|ensemblprotists:DDB_G0269238(gene)|ensemblprotists:EAL71969(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0000331"(contractile vacuole)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005768"(endosome)|go:"GO:0005811"(lipid droplet)|go:"GO:0006887"(exocytosis)|go:"GO:0007231"(osmosensory signaling pathway)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0015031"(protein transport)|go:"GO:0031164"(contractile vacuolar membrane)|go:"GO:0032482"(Rab protein signal transduction)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0033298"(contractile vacuole organization)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0055037"(recycling endosome)|go:"GO:0071476"(cellular hypotonic response)|go:"GO:0140220"(pathogen-containing vacuole)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P36412|reactome:R-DDI-8854214|reactome:R-DDI-8873719|refseq:XP_646557.1|mint:MINT-6947832(identity)	dictybase:DDB_G0288405|go:"GO:0005096"(GTPase activator activity)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0016020"(membrane)|go:"GO:0030054"(cell junction)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0090630"(activation of GTPase activity)|interpro:IPR000195(RabGAP/TBC)|interpro:IPR006571(TLDc)|interpro:IPR035969|mint:Q54IZ7|refseq:XP_636733.1|mint:MINT-6947833(identity)	go:"GO:0000331"(contractile vacuole)	function:Required for normal contractile vacuole structure and function. Cells expressing a dominant negative rab11A exhibit a more extensive contractile vacuole network and enlarged contractile vacuole bladders. These cells exhibit a functional defect in osmotic regulation where cells immersed in water become rounded and detach from the surface, and contain swollen contractile vacuoles|comment:mint	comment:mint	figure legend:f5a|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:44689(dicdi)|taxid:44689("Dictyostelium discoideum (Slime mold)")	-	2009/02/12	2014/10/16	rogid:R8B5PiCYJ2oD3rfjrjUtMrwhSfc44689	rogid:kMyjeo67TX8/skQPuvFMqYL+Otg44689	intact-crc:E8DD8E8BCEEEFECB|rigid:A86YoHt5GUFx7tAufCADoWozxBU	false	tag:?-?(MINT-6947840)	green fluorescent protein tag:?-?(MINT-6947836)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q54IZ7	uniprotkb:Q550H6	intact:EBI-8025538|intact:MINT-6947817	intact:EBI-8025639|intact:MINT-6947891|ensemblprotists:EAL69052	psi-mi:q54iz7_dicdi(display_long)|uniprotkb:DDB0187927(orf name)	psi-mi:rb11c_dicdi(display_long)|uniprotkb:rab11C(gene name)|psi-mi:rab11C(display_short)|uniprotkb:DDB_G0277101(orf name)	psi-mi:"MI:0416"(fluorescence microscopy)	Du et al. (2008)	pubmed:18636095|imex:IM-11658|mint:MINT-6947792|doi:10.1038/emboj.2008.131	taxid:44689(dicdi)|taxid:44689("Dictyostelium discoideum (Slime mold)")	taxid:44689(dicdi)|taxid:44689("Dictyostelium discoideum (Slime mold)")	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-8025633|mint:MINT-6947879|imex:IM-11658-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dictybase:DDB_G0288405|go:"GO:0005096"(GTPase activator activity)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0016020"(membrane)|go:"GO:0030054"(cell junction)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0090630"(activation of GTPase activity)|interpro:IPR000195(RabGAP/TBC)|interpro:IPR006571(TLDc)|interpro:IPR035969|mint:Q54IZ7|refseq:XP_636733.1|mint:MINT-6947886(identity)	dictybase:DDB_G0277101|ensemblprotists:DDB_G0277101(gene)|ensemblprotists:EAL69052(transcript)|go:"GO:0000331"(contractile vacuole)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0140220"(pathogen-containing vacuole)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:Q550H6|refseq:XP_642956.1|mint:MINT-6947882(identity)	go:"GO:0000331"(contractile vacuole)	comment:mint	comment:mint	figure legend:f5a|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:44689(dicdi)|taxid:44689("Dictyostelium discoideum (Slime mold)")	-	2009/02/12	2014/10/16	rogid:kMyjeo67TX8/skQPuvFMqYL+Otg44689	rogid:uBDAZbPyHN1AvgYK0X0cZ9OXD0E44689	intact-crc:2C65AC7A856CBA0E|rigid:Oieupeyxv/S6ABfMEh6xweFOywQ	false	green fluorescent protein tag:?-?(MINT-6947887)	tag:?-?(MINT-6947883)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P20790	uniprotkb:Q54IZ7	intact:EBI-8025587|uniprotkb:Q54VH5|intact:MINT-6947856|ensemblprotists:EAL67248	intact:EBI-8025538|intact:MINT-6947817	psi-mi:rab8a_dicdi(display_long)|uniprotkb:rab8A(gene name)|psi-mi:rab8A(display_short)|uniprotkb:sas1(gene name synonym)|uniprotkb:sasA(gene name synonym)|uniprotkb:GTP-binding protein SAS1(gene name synonym)|uniprotkb:DDB_G0280043(orf name)	psi-mi:q54iz7_dicdi(display_long)|uniprotkb:DDB0187927(orf name)	psi-mi:"MI:0416"(fluorescence microscopy)	Du et al. (2008)	pubmed:18636095|imex:IM-11658|mint:MINT-6947792|doi:10.1038/emboj.2008.131	taxid:44689(dicdi)|taxid:44689("Dictyostelium discoideum (Slime mold)")	taxid:44689(dicdi)|taxid:44689("Dictyostelium discoideum (Slime mold)")	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-8025615|mint:MINT-6947844|imex:IM-11658-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dictybase:DDB_G0280043|ensemblprotists:DDB_G0280043(gene)|ensemblprotists:EAL67248(transcript)|go:"GO:0000331"(contractile vacuole)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005811"(lipid droplet)|go:"GO:0005886"(plasma membrane)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0009306"(protein secretion)|go:"GO:0016339"(calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0031157"(regulation of aggregate size involved in sorocarp development)|go:"GO:0031164"(contractile vacuolar membrane)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0033298"(contractile vacuole organization)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0050708"(regulation of protein secretion)|go:"GO:0051600"(regulation of endocytosis by exocyst localization)|go:"GO:0070177"(contractile vacuole discharge)|go:"GO:0140025"(contractile vacuole tethering involved in discharge)|go:"GO:0140220"(pathogen-containing vacuole)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P20790|reactome:R-DDI-210500|reactome:R-DDI-6798695|reactome:R-DDI-8873719|refseq:XP_641380.1|mint:MINT-6947851(identity)	dictybase:DDB_G0288405|go:"GO:0005096"(GTPase activator activity)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0016020"(membrane)|go:"GO:0030054"(cell junction)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0090630"(activation of GTPase activity)|interpro:IPR000195(RabGAP/TBC)|interpro:IPR006571(TLDc)|interpro:IPR035969|mint:Q54IZ7|refseq:XP_636733.1|mint:MINT-6947847(identity)	go:"GO:0000331"(contractile vacuole)	comment:mint|function:Protein transport. Probably involved in vesicular traffic	comment:mint	figure legend:f5a|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:44689(dicdi)|taxid:44689("Dictyostelium discoideum (Slime mold)")	-	2009/02/12	2014/10/16	rogid:OWMnoBErwV6Ckz+wShzJ3JUlg+A44689	rogid:kMyjeo67TX8/skQPuvFMqYL+Otg44689	intact-crc:8441C289AA49E9DB|rigid:wzXet7o7SX0P6nvsjyaX7PPcHp4	false	tag:?-?(MINT-6947852)	green fluorescent protein tag:?-?(MINT-6947848)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O96904	uniprotkb:P36412	intact:EBI-8025675|intact:MINT-6947951|uniprotkb:Q55CU5|ensemblprotists:EAL71915	intact:EBI-8025515|uniprotkb:Q55CC4|intact:MINT-6947977|ensemblprotists:EAL71969	psi-mi:tbc12_dicdi(display_long)|uniprotkb:phgA(gene name)|psi-mi:phgA(display_short)|uniprotkb:DDB_G0269130(orf name)|uniprotkb:TBC1 domain family member 12 homolog(gene name synonym)	psi-mi:rb11a_dicdi(display_long)|uniprotkb:rab11A(gene name)|psi-mi:rab11A(display_short)|uniprotkb:rab11(gene name synonym)|uniprotkb:DDB_G0269238(orf name)	psi-mi:"MI:0416"(fluorescence microscopy)	Du et al. (2008)	pubmed:18636095|imex:IM-11658|mint:MINT-6947792|doi:10.1038/emboj.2008.131	taxid:44689(dicdi)|taxid:44689("Dictyostelium discoideum (Slime mold)")	taxid:44689(dicdi)|taxid:44689("Dictyostelium discoideum (Slime mold)")	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0471"(MINT)	intact:EBI-8025669|mint:MINT-6948028|imex:IM-11658-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dictybase:DDB_G0269130|ensemblprotists:DDB_G0269130(gene)|ensemblprotists:EAL71915(transcript)|go:"GO:0000331"(contractile vacuole)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006971"(hypotonic response)|go:"GO:0031164"(contractile vacuolar membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0033298"(contractile vacuole organization)|go:"GO:0051600"(regulation of endocytosis by exocyst localization)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0140028"(pore formation during contractile vacuole discharge)|interpro:IPR000195(RabGAP/TBC)|interpro:IPR035969|mint:O96904|reactome:R-DDI-8854214|refseq:XP_646386.1|mint:MINT-6948035(identity)	dictybase:DDB_G0269238|ensemblprotists:DDB_G0269238(gene)|ensemblprotists:EAL71969(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0000331"(contractile vacuole)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005768"(endosome)|go:"GO:0005811"(lipid droplet)|go:"GO:0006887"(exocytosis)|go:"GO:0007231"(osmosensory signaling pathway)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0015031"(protein transport)|go:"GO:0031164"(contractile vacuolar membrane)|go:"GO:0032482"(Rab protein signal transduction)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0033298"(contractile vacuole organization)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0055037"(recycling endosome)|go:"GO:0071476"(cellular hypotonic response)|go:"GO:0140220"(pathogen-containing vacuole)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P36412|reactome:R-DDI-8854214|reactome:R-DDI-8873719|refseq:XP_646557.1|mint:MINT-6948031(identity)	go:"GO:0000331"(contractile vacuole)	function:"May act as a GTPase-activating protein for Rab family protein(s) (By similarity). Required for osmotic regulation by the contractile vacuole in hypo-osmotic environments. Essential for periodic fusion of the contractile vacuole with the plasma membrane and consequent expulsion of water from the cell body"|comment:mint	function:Required for normal contractile vacuole structure and function. Cells expressing a dominant negative rab11A exhibit a more extensive contractile vacuole network and enlarged contractile vacuole bladders. These cells exhibit a functional defect in osmotic regulation where cells immersed in water become rounded and detach from the surface, and contain swollen contractile vacuoles|comment:mint	figure legend:f5e|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:44689(dicdi)|taxid:44689("Dictyostelium discoideum (Slime mold)")	-	2009/02/12	2014/10/16	rogid:KCiQrmSbkBCIEbeg6EkbD7Ftebc44689	rogid:R8B5PiCYJ2oD3rfjrjUtMrwhSfc44689	intact-crc:1D96249B1F0FFEEA|rigid:SIvjx4LCwSpDeTno4VWAD+kAW7M	false	green fluorescent protein tag:?-?(MINT-6948036)	tag:?-?(MINT-6948032)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P36410	uniprotkb:O96904	intact:EBI-8025720|intact:MINT-6947926|uniprotkb:Q54U25|ensemblprotists:EAL66754	intact:EBI-8025675|intact:MINT-6947951|uniprotkb:Q55CU5|ensemblprotists:EAL71915	psi-mi:rab14_dicdi(display_long)|uniprotkb:Rab4-like GTPase(gene name synonym)|uniprotkb:rab14(gene name)|psi-mi:rab14(display_short)|uniprotkb:rab4(gene name synonym)|uniprotkb:rabD(gene name synonym)|uniprotkb:DDB_G0281337(orf name)	psi-mi:tbc12_dicdi(display_long)|uniprotkb:phgA(gene name)|psi-mi:phgA(display_short)|uniprotkb:DDB_G0269130(orf name)|uniprotkb:TBC1 domain family member 12 homolog(gene name synonym)	psi-mi:"MI:0096"(pull down)	Du et al. (2008)	pubmed:18636095|imex:IM-11658|mint:MINT-6947792|doi:10.1038/emboj.2008.131	taxid:44689(dicdi)|taxid:44689("Dictyostelium discoideum (Slime mold)")	taxid:44689(dicdi)|taxid:44689("Dictyostelium discoideum (Slime mold)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8025715|mint:MINT-6947912|imex:IM-11658-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dictybase:DDB_G0281337|ensemblprotists:DDB_G0281337(gene)|ensemblprotists:EAL66754(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005769"(early endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006895"(Golgi to endosome transport)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0012505"(endomembrane system)|go:"GO:0031164"(contractile vacuolar membrane)|go:"GO:0032456"(endocytic recycling)|go:"GO:0033298"(contractile vacuole organization)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048548"(regulation of pinocytosis)|go:"GO:0055037"(recycling endosome)|go:"GO:0062160"(spongiome)|go:"GO:0090387"(phagolysosome assembly involved in apoptotic cell clearance)|go:"GO:0140220"(pathogen-containing vacuole)|go:"GO:1905364"(regulation of endosomal vesicle fusion)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR030702|mint:P36410|reactome:R-DDI-6798695|reactome:R-DDI-8873719|reactome:R-DDI-8876198|refseq:XP_640740.1|mint:MINT-6947919(identity)	dictybase:DDB_G0269130|ensemblprotists:DDB_G0269130(gene)|ensemblprotists:EAL71915(transcript)|go:"GO:0000331"(contractile vacuole)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006971"(hypotonic response)|go:"GO:0031164"(contractile vacuolar membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0033298"(contractile vacuole organization)|go:"GO:0051600"(regulation of endocytosis by exocyst localization)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0140028"(pore formation during contractile vacuole discharge)|interpro:IPR000195(RabGAP/TBC)|interpro:IPR035969|mint:O96904|reactome:R-DDI-8854214|refseq:XP_646386.1|mint:MINT-6947915(identity)	-	function:Regulates the fusion of phagosomes and lysosomes|comment:mint	function:"May act as a GTPase-activating protein for Rab family protein(s) (By similarity). Required for osmotic regulation by the contractile vacuole in hypo-osmotic environments. Essential for periodic fusion of the contractile vacuole with the plasma membrane and consequent expulsion of water from the cell body"|comment:mint	figure legend:f5b|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/02/12	2014/10/16	rogid:wdGigLQcd6TiyYCQxs0Xu37/tgU44689	rogid:KCiQrmSbkBCIEbeg6EkbD7Ftebc44689	intact-crc:60914381139A4CB7|rigid:C+gRkmtpO0jZxIBSLrWYSXKX2BQ	false	glutathione s tranferase tag:?-?(MINT-6947920)	v5 tag:?-?(MINT-6947916)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:O96904	uniprotkb:P36412	intact:EBI-8025675|intact:MINT-6947951|uniprotkb:Q55CU5|ensemblprotists:EAL71915	intact:EBI-8025515|uniprotkb:Q55CC4|intact:MINT-6947977|ensemblprotists:EAL71969	psi-mi:tbc12_dicdi(display_long)|uniprotkb:phgA(gene name)|psi-mi:phgA(display_short)|uniprotkb:DDB_G0269130(orf name)|uniprotkb:TBC1 domain family member 12 homolog(gene name synonym)	psi-mi:rb11a_dicdi(display_long)|uniprotkb:rab11A(gene name)|psi-mi:rab11A(display_short)|uniprotkb:rab11(gene name synonym)|uniprotkb:DDB_G0269238(orf name)	psi-mi:"MI:0096"(pull down)	Du et al. (2008)	pubmed:18636095|imex:IM-11658|mint:MINT-6947792|doi:10.1038/emboj.2008.131	taxid:44689(dicdi)|taxid:44689("Dictyostelium discoideum (Slime mold)")	taxid:44689(dicdi)|taxid:44689("Dictyostelium discoideum (Slime mold)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8025775|mint:MINT-6947966|imex:IM-11658-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dictybase:DDB_G0269130|ensemblprotists:DDB_G0269130(gene)|ensemblprotists:EAL71915(transcript)|go:"GO:0000331"(contractile vacuole)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006971"(hypotonic response)|go:"GO:0031164"(contractile vacuolar membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0033298"(contractile vacuole organization)|go:"GO:0051600"(regulation of endocytosis by exocyst localization)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0140028"(pore formation during contractile vacuole discharge)|interpro:IPR000195(RabGAP/TBC)|interpro:IPR035969|mint:O96904|reactome:R-DDI-8854214|refseq:XP_646386.1|mint:MINT-6947968(identity)	dictybase:DDB_G0269238|ensemblprotists:DDB_G0269238(gene)|ensemblprotists:EAL71969(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0000331"(contractile vacuole)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005768"(endosome)|go:"GO:0005811"(lipid droplet)|go:"GO:0006887"(exocytosis)|go:"GO:0007231"(osmosensory signaling pathway)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0015031"(protein transport)|go:"GO:0031164"(contractile vacuolar membrane)|go:"GO:0032482"(Rab protein signal transduction)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0033298"(contractile vacuole organization)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0055037"(recycling endosome)|go:"GO:0071476"(cellular hypotonic response)|go:"GO:0140220"(pathogen-containing vacuole)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P36412|reactome:R-DDI-8854214|reactome:R-DDI-8873719|refseq:XP_646557.1|mint:MINT-6947972(identity)	-	function:"May act as a GTPase-activating protein for Rab family protein(s) (By similarity). Required for osmotic regulation by the contractile vacuole in hypo-osmotic environments. Essential for periodic fusion of the contractile vacuole with the plasma membrane and consequent expulsion of water from the cell body"|comment:mint	function:Required for normal contractile vacuole structure and function. Cells expressing a dominant negative rab11A exhibit a more extensive contractile vacuole network and enlarged contractile vacuole bladders. These cells exhibit a functional defect in osmotic regulation where cells immersed in water become rounded and detach from the surface, and contain swollen contractile vacuoles|comment:mint	figure legend:f5b|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/02/12	2014/10/16	rogid:KCiQrmSbkBCIEbeg6EkbD7Ftebc44689	rogid:R8B5PiCYJ2oD3rfjrjUtMrwhSfc44689	intact-crc:447BF83CC55982F1|rigid:SIvjx4LCwSpDeTno4VWAD+kAW7M	false	v5 tag:?-?(MINT-6947969)	glutathione s tranferase tag:?-?(MINT-6947973)	-	-	psi-mi:"MI:0705"(anti tag western blot)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P20790	uniprotkb:Q54IZ7	intact:EBI-8025587|uniprotkb:Q54VH5|intact:MINT-6947856|ensemblprotists:EAL67248	intact:EBI-8025538|intact:MINT-6947817	psi-mi:rab8a_dicdi(display_long)|uniprotkb:rab8A(gene name)|psi-mi:rab8A(display_short)|uniprotkb:sas1(gene name synonym)|uniprotkb:sasA(gene name synonym)|uniprotkb:GTP-binding protein SAS1(gene name synonym)|uniprotkb:DDB_G0280043(orf name)	psi-mi:q54iz7_dicdi(display_long)|uniprotkb:DDB0187927(orf name)	psi-mi:"MI:0096"(pull down)	Du et al. (2008)	pubmed:18636095|imex:IM-11658|mint:MINT-6947792|doi:10.1038/emboj.2008.131	taxid:44689(dicdi)|taxid:44689("Dictyostelium discoideum (Slime mold)")	taxid:44689(dicdi)|taxid:44689("Dictyostelium discoideum (Slime mold)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8025809|mint:MINT-6948016|imex:IM-11658-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dictybase:DDB_G0280043|ensemblprotists:DDB_G0280043(gene)|ensemblprotists:EAL67248(transcript)|go:"GO:0000331"(contractile vacuole)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005811"(lipid droplet)|go:"GO:0005886"(plasma membrane)|go:"GO:0006904"(vesicle docking involved in exocytosis)|go:"GO:0009306"(protein secretion)|go:"GO:0016339"(calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0031157"(regulation of aggregate size involved in sorocarp development)|go:"GO:0031164"(contractile vacuolar membrane)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0033298"(contractile vacuole organization)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0050708"(regulation of protein secretion)|go:"GO:0051600"(regulation of endocytosis by exocyst localization)|go:"GO:0070177"(contractile vacuole discharge)|go:"GO:0140025"(contractile vacuole tethering involved in discharge)|go:"GO:0140220"(pathogen-containing vacuole)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P20790|reactome:R-DDI-210500|reactome:R-DDI-6798695|reactome:R-DDI-8873719|refseq:XP_641380.1|mint:MINT-6948022(identity)	dictybase:DDB_G0288405|go:"GO:0005096"(GTPase activator activity)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0016020"(membrane)|go:"GO:0030054"(cell junction)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0090630"(activation of GTPase activity)|interpro:IPR000195(RabGAP/TBC)|interpro:IPR006571(TLDc)|interpro:IPR035969|mint:Q54IZ7|refseq:XP_636733.1|mint:MINT-6948018(identity)	-	comment:mint|function:Protein transport. Probably involved in vesicular traffic	comment:mint	figure legend:f5b|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/02/12	2014/10/16	rogid:OWMnoBErwV6Ckz+wShzJ3JUlg+A44689	rogid:kMyjeo67TX8/skQPuvFMqYL+Otg44689	intact-crc:9A039468186E60D5|rigid:wzXet7o7SX0P6nvsjyaX7PPcHp4	false	glutathione s tranferase tag:?-?(MINT-6948023)	v5 tag:?-?(MINT-6948019)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0705"(anti tag western blot)
uniprotkb:P36412	uniprotkb:Q54IZ7	intact:EBI-8025515|uniprotkb:Q55CC4|intact:MINT-6947977|ensemblprotists:EAL71969	intact:EBI-8025538|intact:MINT-6947817	psi-mi:rb11a_dicdi(display_long)|uniprotkb:rab11A(gene name)|psi-mi:rab11A(display_short)|uniprotkb:rab11(gene name synonym)|uniprotkb:DDB_G0269238(orf name)	psi-mi:q54iz7_dicdi(display_long)|uniprotkb:DDB0187927(orf name)	psi-mi:"MI:0096"(pull down)	Du et al. (2008)	pubmed:18636095|imex:IM-11658|mint:MINT-6947792|doi:10.1038/emboj.2008.131	taxid:44689(dicdi)|taxid:44689("Dictyostelium discoideum (Slime mold)")	taxid:44689(dicdi)|taxid:44689("Dictyostelium discoideum (Slime mold)")	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-8025792|mint:MINT-6948000|imex:IM-11658-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dictybase:DDB_G0269238|ensemblprotists:DDB_G0269238(gene)|ensemblprotists:EAL71969(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0000331"(contractile vacuole)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005768"(endosome)|go:"GO:0005811"(lipid droplet)|go:"GO:0006887"(exocytosis)|go:"GO:0007231"(osmosensory signaling pathway)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0015031"(protein transport)|go:"GO:0031164"(contractile vacuolar membrane)|go:"GO:0032482"(Rab protein signal transduction)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0033298"(contractile vacuole organization)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0055037"(recycling endosome)|go:"GO:0071476"(cellular hypotonic response)|go:"GO:0140220"(pathogen-containing vacuole)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P36412|reactome:R-DDI-8854214|reactome:R-DDI-8873719|refseq:XP_646557.1|mint:MINT-6948003(identity)	dictybase:DDB_G0288405|go:"GO:0005096"(GTPase activator activity)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0016020"(membrane)|go:"GO:0030054"(cell junction)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0090630"(activation of GTPase activity)|interpro:IPR000195(RabGAP/TBC)|interpro:IPR006571(TLDc)|interpro:IPR035969|mint:Q54IZ7|refseq:XP_636733.1|mint:MINT-6948007(identity)	-	function:Required for normal contractile vacuole structure and function. Cells expressing a dominant negative rab11A exhibit a more extensive contractile vacuole network and enlarged contractile vacuole bladders. These cells exhibit a functional defect in osmotic regulation where cells immersed in water become rounded and detach from the surface, and contain swollen contractile vacuoles|comment:mint	comment:mint	figure legend:f5b|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/02/12	2014/10/16	rogid:R8B5PiCYJ2oD3rfjrjUtMrwhSfc44689	rogid:kMyjeo67TX8/skQPuvFMqYL+Otg44689	intact-crc:803748263E3531EB|rigid:A86YoHt5GUFx7tAufCADoWozxBU	false	glutathione s tranferase tag:?-?(MINT-6948004)	v5 tag:?-?(MINT-6948008)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0705"(anti tag western blot)