#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:O08689	uniprotkb:Q96NZ8	intact:EBI-2366774|ensembl:ENSMUSP00000027269	intact:EBI-2363713|uniprotkb:Q7LDW0|uniprotkb:Q8NBQ1|uniprotkb:Q96S20|ensembl:ENSP00000324763	psi-mi:gdf8_mouse(display_long)|uniprotkb:Mstn(gene name)|psi-mi:Mstn(display_short)|uniprotkb:Gdf8(gene name synonym)|uniprotkb:Myostatin(gene name synonym)	psi-mi:wfkn1_human(display_long)|uniprotkb:WFIKKN1(gene name)|psi-mi:WFIKKN1(display_short)|uniprotkb:GASP2(gene name synonym)|uniprotkb:WFIKKN(gene name synonym)|uniprotkb:Growth and differentiation factor-associated serum protein 2(gene name synonym)|uniprotkb:PSEC0040(orf name)|uniprotkb:C16orf12(gene name synonym)|uniprotkb:WAP, follistatin, immunoglobulin, Kunitz and NTR domain-containing protein(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Kondas et al. (2008)	pubmed:18596030|imex:IM-20327	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2363711|imex:IM-20327-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_034964.1|ensembl:ENSMUSG00000026100(gene)|ensembl:ENSMUST00000027269(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0008083"(growth factor activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009408"(response to heat)|go:"GO:0009629"(response to gravity)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0014732"(skeletal muscle atrophy)|go:"GO:0014741"(negative regulation of muscle hypertrophy)|go:"GO:0014839"(myoblast migration involved in skeletal muscle regeneration)|go:"GO:0014850"(response to muscle activity)|go:"GO:0022602"(ovulation cycle process)|go:"GO:0033574"(response to testosterone)|go:"GO:0033673"(negative regulation of kinase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043627"(response to estrogen)|go:"GO:0045471"(response to ethanol)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0048632"(negative regulation of skeletal muscle tissue growth)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:1902723"(negative regulation of skeletal muscle satellite cell proliferation)|go:"GO:1902725"(negative regulation of satellite cell differentiation)|go:"GO:2000818"(negative regulation of myoblast proliferation)|interpro:IPR001111("Transforming growth factor beta (TGFb), N-terminal")|interpro:IPR001839(Transforming growth factor beta)|interpro:IPR015615(Transforming growth factor-beta-related)|interpro:IPR015616(Growth and differentiation factor 8)|interpro:IPR017948|interpro:IPR029034|rcsb pdb:3HH2|rcsb pdb:3SEK|rcsb pdb:5JI1|go:"GO:0045662"(negative regulation of myoblast differentiation)	refseq:NP_444514.1|ensembl:ENSG00000127578(gene)|ensembl:ENST00000319070(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0008191"(metalloendopeptidase inhibitor activity)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0048019"(receptor antagonist activity)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0055001"(muscle cell development)|go:"GO:0060021"(roof of mouth development)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR002223(Proteinase inhibitor I2, Kunitz metazoa)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008197(Whey acidic protein, 4-disulphide core)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR020901|interpro:IPR033638|interpro:IPR036058|interpro:IPR036179|interpro:IPR036645|interpro:IPR036880|rcsb pdb:2DDI|rcsb pdb:2DDJ	-	-	-	figure legend:Table 1 and 2|caution:Exact FS domain and NTR region of human WFIKKN1 not given in the text so has been inferred from the UniProtKB entry.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/07/13	2014/10/16	rogid:x/AR38nYKdyVtykd0YgBsV2IXL010090	rogid:T8DL/AiecDjKCbVgU31xMrq5pxM9606	intact-crc:EE3CD84B6A50520B|rigid:V5aMnsulaOfeMJcTnPpAASQTDrk	false	-	sufficient binding region:409..409-540(IPR001134)|sufficient binding region:115..115-157..157(IPR002350)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O08689	uniprotkb:Q8TEU8	intact:EBI-2366774|ensembl:ENSMUSP00000027269	intact:EBI-2363745|uniprotkb:Q6UXZ9|ensembl:ENSP00000311184	psi-mi:gdf8_mouse(display_long)|uniprotkb:Mstn(gene name)|psi-mi:Mstn(display_short)|uniprotkb:Gdf8(gene name synonym)|uniprotkb:Myostatin(gene name synonym)	psi-mi:wfkn2_human(display_long)|uniprotkb:WFIKKN2(gene name)|psi-mi:WFIKKN2(display_short)|uniprotkb:GASP1(gene name synonym)|uniprotkb:WFIKKNRP(gene name synonym)|uniprotkb:WFIKKN-related protein(gene name synonym)|uniprotkb:Growth and differentiation factor-associated serum protein 1(gene name synonym)|uniprotkb:UNQ9235/PRO31996(orf name)|uniprotkb:WAP, follistatin, immunoglobulin, Kunitz and NTR domain-containing-related protein(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Kondas et al. (2008)	pubmed:18596030|imex:IM-20327	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2363773|imex:IM-20327-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_034964.1|ensembl:ENSMUSG00000026100(gene)|ensembl:ENSMUST00000027269(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005125"(cytokine activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0008083"(growth factor activity)|go:"GO:0008201"(heparin binding)|go:"GO:0009408"(response to heat)|go:"GO:0009629"(response to gravity)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0014732"(skeletal muscle atrophy)|go:"GO:0014741"(negative regulation of muscle hypertrophy)|go:"GO:0014839"(myoblast migration involved in skeletal muscle regeneration)|go:"GO:0014850"(response to muscle activity)|go:"GO:0022602"(ovulation cycle process)|go:"GO:0033574"(response to testosterone)|go:"GO:0033673"(negative regulation of kinase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043627"(response to estrogen)|go:"GO:0045471"(response to ethanol)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0048632"(negative regulation of skeletal muscle tissue growth)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:1902723"(negative regulation of skeletal muscle satellite cell proliferation)|go:"GO:1902725"(negative regulation of satellite cell differentiation)|go:"GO:2000818"(negative regulation of myoblast proliferation)|interpro:IPR001111("Transforming growth factor beta (TGFb), N-terminal")|interpro:IPR001839(Transforming growth factor beta)|interpro:IPR015615(Transforming growth factor-beta-related)|interpro:IPR015616(Growth and differentiation factor 8)|interpro:IPR017948|interpro:IPR029034|rcsb pdb:3HH2|rcsb pdb:3SEK|rcsb pdb:5JI1|go:"GO:0045662"(negative regulation of myoblast differentiation)	refseq:NP_783165.1|refseq:NP_001317270.1|ensembl:ENSG00000173714(gene)|ensembl:ENST00000311378(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0008191"(metalloendopeptidase inhibitor activity)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0048019"(receptor antagonist activity)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0055001"(muscle cell development)|go:"GO:0060021"(roof of mouth development)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR002223(Proteinase inhibitor I2, Kunitz metazoa)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008197(Whey acidic protein, 4-disulphide core)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR018933|interpro:IPR020901|interpro:IPR033638|interpro:IPR036058|interpro:IPR036179|interpro:IPR036645|interpro:IPR036880	-	-	-	figure legend:Table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/07/13	2014/10/16	rogid:x/AR38nYKdyVtykd0YgBsV2IXL010090	rogid:+VupfnZIxb0KC68euSwEZWwWnIg9606	intact-crc:E89B3606B23E3327|rigid:63Iv/1qxgo8ObabA4PaVjq8fhII	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8TEU8	uniprotkb:O95390	intact:EBI-2363745|uniprotkb:Q6UXZ9|ensembl:ENSP00000311184	intact:EBI-2363776|uniprotkb:Q9UID1|uniprotkb:Q9UID2|ensembl:ENSP00000257868	psi-mi:wfkn2_human(display_long)|uniprotkb:WFIKKN2(gene name)|psi-mi:WFIKKN2(display_short)|uniprotkb:GASP1(gene name synonym)|uniprotkb:WFIKKNRP(gene name synonym)|uniprotkb:WFIKKN-related protein(gene name synonym)|uniprotkb:Growth and differentiation factor-associated serum protein 1(gene name synonym)|uniprotkb:UNQ9235/PRO31996(orf name)|uniprotkb:WAP, follistatin, immunoglobulin, Kunitz and NTR domain-containing-related protein(gene name synonym)	psi-mi:gdf11_human(display_long)|uniprotkb:GDF11(gene name)|psi-mi:GDF11(display_short)|uniprotkb:BMP11(gene name synonym)|uniprotkb:Bone morphogenetic protein 11(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Kondas et al. (2008)	pubmed:18596030|imex:IM-20327	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2363797|imex:IM-20327-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_783165.1|refseq:NP_001317270.1|ensembl:ENSG00000173714(gene)|ensembl:ENST00000311378(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0008191"(metalloendopeptidase inhibitor activity)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0048019"(receptor antagonist activity)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0055001"(muscle cell development)|go:"GO:0060021"(roof of mouth development)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR002223(Proteinase inhibitor I2, Kunitz metazoa)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008197(Whey acidic protein, 4-disulphide core)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR018933|interpro:IPR020901|interpro:IPR033638|interpro:IPR036058|interpro:IPR036179|interpro:IPR036645|interpro:IPR036880	refseq:NP_005802.1|refseq:XP_006719257.1|ensembl:ENSG00000135414(gene)|ensembl:ENST00000257868(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0005125"(cytokine activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005654"(nucleoplasm)|go:"GO:0007399"(nervous system development)|go:"GO:0007498"(mesoderm development)|go:"GO:0008083"(growth factor activity)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0060395"(SMAD protein signal transduction)|interpro:IPR001111("Transforming growth factor beta (TGFb), N-terminal")|interpro:IPR001839(Transforming growth factor beta)|interpro:IPR015615(Transforming growth factor-beta-related)|interpro:IPR017948|interpro:IPR029034|mint:O95390|rcsb pdb:5E4G|rcsb pdb:5JHW|rcsb pdb:5UHM|rcsb pdb:6MAC	-	-	-	figure legend:table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/07/13	2014/10/16	rogid:+VupfnZIxb0KC68euSwEZWwWnIg9606	rogid:0UYBp3hPao/xUd6YGfgn05Pf/w49606	intact-crc:72F348CB91AC218E|rigid:BSr6yEFXHK5EEALXtnLkoZjzpus	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:O95390	uniprotkb:Q96NZ8	intact:EBI-2363776|uniprotkb:Q9UID1|uniprotkb:Q9UID2|ensembl:ENSP00000257868	intact:EBI-2363713|uniprotkb:Q7LDW0|uniprotkb:Q8NBQ1|uniprotkb:Q96S20|ensembl:ENSP00000324763	psi-mi:gdf11_human(display_long)|uniprotkb:GDF11(gene name)|psi-mi:GDF11(display_short)|uniprotkb:BMP11(gene name synonym)|uniprotkb:Bone morphogenetic protein 11(gene name synonym)	psi-mi:wfkn1_human(display_long)|uniprotkb:WFIKKN1(gene name)|psi-mi:WFIKKN1(display_short)|uniprotkb:GASP2(gene name synonym)|uniprotkb:WFIKKN(gene name synonym)|uniprotkb:Growth and differentiation factor-associated serum protein 2(gene name synonym)|uniprotkb:PSEC0040(orf name)|uniprotkb:C16orf12(gene name synonym)|uniprotkb:WAP, follistatin, immunoglobulin, Kunitz and NTR domain-containing protein(gene name synonym)	psi-mi:"MI:0107"(surface plasmon resonance)	Kondas et al. (2008)	pubmed:18596030|imex:IM-20327	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2363823|imex:IM-20327-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_005802.1|refseq:XP_006719257.1|ensembl:ENSG00000135414(gene)|ensembl:ENST00000257868(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0005125"(cytokine activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005654"(nucleoplasm)|go:"GO:0007399"(nervous system development)|go:"GO:0007498"(mesoderm development)|go:"GO:0008083"(growth factor activity)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0060395"(SMAD protein signal transduction)|interpro:IPR001111("Transforming growth factor beta (TGFb), N-terminal")|interpro:IPR001839(Transforming growth factor beta)|interpro:IPR015615(Transforming growth factor-beta-related)|interpro:IPR017948|interpro:IPR029034|mint:O95390|rcsb pdb:5E4G|rcsb pdb:5JHW|rcsb pdb:5UHM|rcsb pdb:6MAC	refseq:NP_444514.1|ensembl:ENSG00000127578(gene)|ensembl:ENST00000319070(transcript)|go:"GO:0001501"(skeletal system development)|go:"GO:0004867"(serine-type endopeptidase inhibitor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0008191"(metalloendopeptidase inhibitor activity)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0048019"(receptor antagonist activity)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0055001"(muscle cell development)|go:"GO:0060021"(roof of mouth development)|interpro:IPR001134(Netrin, C-terminal)|interpro:IPR002223(Proteinase inhibitor I2, Kunitz metazoa)|interpro:IPR002350(Proteinase inhibitor I1, Kazal)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR008197(Whey acidic protein, 4-disulphide core)|interpro:IPR008993(TIMP-like, OB-fold)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR020901|interpro:IPR033638|interpro:IPR036058|interpro:IPR036179|interpro:IPR036645|interpro:IPR036880|rcsb pdb:2DDI|rcsb pdb:2DDJ	-	-	-	figure legend:table 1|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/07/13	2014/10/16	rogid:0UYBp3hPao/xUd6YGfgn05Pf/w49606	rogid:T8DL/AiecDjKCbVgU31xMrq5pxM9606	intact-crc:BD78C93862C3CED0|rigid:E+XyxUtYJ/BSkmOlax3s3ByW01E	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)