#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P61372	uniprotkb:P50481	intact:EBI-7988215|uniprotkb:P47894|uniprotkb:Q812D8|uniprotkb:P20663|intact:MINT-4594016|ensembl:ENSMUSP00000044879	intact:EBI-7988290|uniprotkb:Q61801|uniprotkb:Q61800|intact:MINT-7009840|ensembl:ENSMUSP00000056822|uniprotkb:A2ALD9	psi-mi:isl1_mouse(display_long)|uniprotkb:Isl1(gene name)|psi-mi:Isl1(display_short)	psi-mi:lhx3_mouse(display_long)|uniprotkb:Lhx3(gene name)|psi-mi:Lhx3(display_short)|uniprotkb:Lim-3(gene name synonym)|uniprotkb:Lim3(gene name synonym)|uniprotkb:Plim(gene name synonym)|uniprotkb:Homeobox protein LIM-3(gene name synonym)|uniprotkb:Homeobox protein P-LIM(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Bhati et al. (2008)	pubmed:18583962|imex:IM-11672|mint:MINT-7009832|doi:10.1038/emboj.2008.123	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7988284|mint:MINT-7009915|imex:IM-11672-10	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067434.3|refseq:XP_006517596.1|ensembl:ENSMUSG00000042258(gene)|ensembl:ENSMUST00000036060(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0048935"(peripheral nervous system neuron development)|go:"GO:0048936"(peripheral nervous system neuron axonogenesis)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0060037"(pharyngeal system development)|go:"GO:0060379"(cardiac muscle cell myoblast differentiation)|go:"GO:0060384"(innervation)|go:"GO:0060413"(atrial septum morphogenesis)|go:"GO:0060913"(cardiac cell fate determination)|go:"GO:0060931"(sinoatrial node cell development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071385"(cellular response to glucocorticoid stimulus)|go:"GO:0071657"(positive regulation of granulocyte colony-stimulating factor production)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1901258"(positive regulation of macrophage colony-stimulating factor production)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR001356(Homeobox)|interpro:IPR001781(Zinc finger, LIM-type)|interpro:IPR009057(Homeodomain-like)|go:"GO:0048880"(sensory system development)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001755"(neural crest cell migration)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003139"(secondary heart field specification)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003215"(cardiac right ventricle morphogenesis)|go:"GO:0003266"(regulation of secondary heart field cardioblast proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0007409"(axonogenesis)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0021520"(spinal cord motor neuron cell fate specification)|go:"GO:0021522"(spinal cord motor neuron differentiation)|go:"GO:0021524"(visceral motor neuron differentiation)|go:"GO:0021559"(trigeminal nerve development)|go:"GO:0021983"(pituitary gland development)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0031016"(pancreas development)|go:"GO:0031103"(axon regeneration)|go:"GO:0031290"(retinal ganglion cell axon guidance)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0032725"(positive regulation of granulocyte macrophage colony-stimulating factor production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032730"(positive regulation of interleukin-1 alpha production)|go:"GO:0007507"(heart development)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0033147"(negative regulation of intracellular estrogen receptor signaling pathway)|mint:P61372|rcsb pdb:2RGT|rcsb pdb:4JCJ|interpro:IPR017970|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048665"(neuron fate specification)|go:"GO:0048762"(mesenchymal cell differentiation)|mint:MINT-7009917(identity)	refseq:NP_001034742.1|refseq:NP_034841.2|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048839"(inner ear development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|interpro:IPR001356(Homeobox)|interpro:IPR001781(Zinc finger, LIM-type)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:P50481|rcsb pdb:2JTN|rcsb pdb:2RGT|ensembl:ENSMUSG00000026934(gene)|ensembl:ENSMUST00000054099(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001890"(placenta development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0021520"(spinal cord motor neuron cell fate specification)|go:"GO:0021521"(ventral spinal cord interneuron specification)|go:"GO:0021526"(medial motor column neuron differentiation)|go:"GO:0021527"(spinal cord association neuron differentiation)|go:"GO:0021983"(pituitary gland development)|go:"GO:0030154"(cell differentiation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030324"(lung development)|mint:MINT-7009921(identity)	-	function:Binds to one of the cis-acting domain of the insulin gene enhancer|comment:mint	function:Binds to and activates the promoter of the alpha-glycoprotein gene, and synergistically enhances transcription from the prolactin promoter in cooperation with Pit-1|comment:mint	figure legend:F1D|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2009/03/03	2014/10/16	rogid:1eir7wLzkoqlwl4AfQuBtjjiyd010090	rogid:8RmeAhxVDKESx4KdOUTVjo3YThE10090	intact-crc:4463BB127D311D50|rigid:9Qx1kTIXB2PNLGoQ/JePSUvPNA8	false	binding-associated region:133-349(MINT-7009918)|tag:?-?(MINT-7009931)	tag:?-?(MINT-7009928)|binding-associated region:28-153(MINT-7009922)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P50481	uniprotkb:P70662	intact:EBI-7988290|uniprotkb:Q61801|uniprotkb:Q61800|intact:MINT-7009840|ensembl:ENSMUSP00000056822|uniprotkb:A2ALD9	intact:EBI-6272082|ensembl:ENSMUSP00000118546|ensembl:ENSMUSP00000139562|uniprotkb:O55204|uniprotkb:Q1EQX2|uniprotkb:Q71V68	psi-mi:lhx3_mouse(display_long)|uniprotkb:Lhx3(gene name)|psi-mi:Lhx3(display_short)|uniprotkb:Lim-3(gene name synonym)|uniprotkb:Lim3(gene name synonym)|uniprotkb:Plim(gene name synonym)|uniprotkb:Homeobox protein LIM-3(gene name synonym)|uniprotkb:Homeobox protein P-LIM(gene name synonym)	psi-mi:ldb1_mouse(display_long)|uniprotkb:Ldb1(gene name)|psi-mi:Ldb1(display_short)|uniprotkb:Nli(gene name synonym)|uniprotkb:Carboxyl-terminal LIM domain-binding protein 2(gene name synonym)|uniprotkb:LIM domain-binding factor CLIM2(gene name synonym)|uniprotkb:Nuclear LIM interactor(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Bhati et al. (2008)	pubmed:18583962|imex:IM-11672|mint:MINT-7009832|doi:10.1038/emboj.2008.123	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7988439|mint:MINT-7010472|imex:IM-11672-3	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001034742.1|refseq:NP_034841.2|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048839"(inner ear development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|interpro:IPR001356(Homeobox)|interpro:IPR001781(Zinc finger, LIM-type)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:P50481|rcsb pdb:2JTN|rcsb pdb:2RGT|ensembl:ENSMUSG00000026934(gene)|ensembl:ENSMUST00000054099(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001890"(placenta development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0021520"(spinal cord motor neuron cell fate specification)|go:"GO:0021521"(ventral spinal cord interneuron specification)|go:"GO:0021526"(medial motor column neuron differentiation)|go:"GO:0021527"(spinal cord association neuron differentiation)|go:"GO:0021983"(pituitary gland development)|go:"GO:0030154"(cell differentiation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030324"(lung development)|mint:MINT-7010474(identity)	ensembl:ENSMUSG00000025223(gene)|ensembl:ENSMUST00000156585(transcript)|ensembl:ENSMUST00000185355(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000972"(transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0001942"(hair follicle development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007399"(nervous system development)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0010669"(epithelial structure maintenance)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0021702"(cerebellar Purkinje cell differentiation)|go:"GO:0022607"(cellular component assembly)|go:"GO:0030154"(cell differentiation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030274"(LIM domain binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0031252"(cell leading edge)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034243"(regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043549"(regulation of kinase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0043973"(histone H3-K4 acetylation)|go:"GO:0045647"(negative regulation of erythrocyte differentiation)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046985"(positive regulation of hemoglobin biosynthetic process)|go:"GO:0048382"(mesendoderm development)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0060319"(primitive erythrocyte differentiation)|go:"GO:0060322"(head development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|rcsb pdb:4JCJ|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|rcsb pdb:6PTL|reactome:R-MMU-8939236|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1990907"(beta-catenin-TCF complex)|interpro:IPR029005|interpro:IPR030167|interpro:IPR041363|mint:P70662|rcsb pdb:1J2O|rcsb pdb:1M3V|rcsb pdb:1RUT|rcsb pdb:2JTN|rcsb pdb:2L6Y|rcsb pdb:2L6Z|rcsb pdb:2LXD|refseq:XP_011245459.1|refseq:NP_001106879.1|refseq:NP_034827.1|dip:DIP-42842N|mint:MINT-7010481(identity)	-	function:Binds to and activates the promoter of the alpha-glycoprotein gene, and synergistically enhances transcription from the prolactin promoter in cooperation with Pit-1|comment:mint	-	figure legend:T3|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2009/03/03	2014/10/16	rogid:8RmeAhxVDKESx4KdOUTVjo3YThE10090	rogid:TWjht9b9thCYJCr+CPgcUWJ4GN810090	intact-crc:3A867E4FF292AD3A|rigid:jsLOVPLArowWZRn4LWufDyWw0Bo	false	binding-associated region:28-153(MINT-7010477)|tag:?-?(MINT-7010475)	mutation disrupting interaction:339-339(MINT-7010544)|binding-associated region:336-366(MINT-7010484)|tag:?-?(MINT-7010482)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P50481	uniprotkb:P70662	intact:EBI-7988290|uniprotkb:Q61801|uniprotkb:Q61800|intact:MINT-7009840|ensembl:ENSMUSP00000056822|uniprotkb:A2ALD9	intact:EBI-6272082|ensembl:ENSMUSP00000118546|ensembl:ENSMUSP00000139562|uniprotkb:O55204|uniprotkb:Q1EQX2|uniprotkb:Q71V68	psi-mi:lhx3_mouse(display_long)|uniprotkb:Lhx3(gene name)|psi-mi:Lhx3(display_short)|uniprotkb:Lim-3(gene name synonym)|uniprotkb:Lim3(gene name synonym)|uniprotkb:Plim(gene name synonym)|uniprotkb:Homeobox protein LIM-3(gene name synonym)|uniprotkb:Homeobox protein P-LIM(gene name synonym)	psi-mi:ldb1_mouse(display_long)|uniprotkb:Ldb1(gene name)|psi-mi:Ldb1(display_short)|uniprotkb:Nli(gene name synonym)|uniprotkb:Carboxyl-terminal LIM domain-binding protein 2(gene name synonym)|uniprotkb:LIM domain-binding factor CLIM2(gene name synonym)|uniprotkb:Nuclear LIM interactor(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Bhati et al. (2008)	pubmed:18583962|imex:IM-11672|mint:MINT-7009832|doi:10.1038/emboj.2008.123	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7988470|mint:MINT-7010548|imex:IM-11672-4	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001034742.1|refseq:NP_034841.2|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048839"(inner ear development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|interpro:IPR001356(Homeobox)|interpro:IPR001781(Zinc finger, LIM-type)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:P50481|rcsb pdb:2JTN|rcsb pdb:2RGT|ensembl:ENSMUSG00000026934(gene)|ensembl:ENSMUST00000054099(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001890"(placenta development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0021520"(spinal cord motor neuron cell fate specification)|go:"GO:0021521"(ventral spinal cord interneuron specification)|go:"GO:0021526"(medial motor column neuron differentiation)|go:"GO:0021527"(spinal cord association neuron differentiation)|go:"GO:0021983"(pituitary gland development)|go:"GO:0030154"(cell differentiation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030324"(lung development)|mint:MINT-7010558(identity)	ensembl:ENSMUSG00000025223(gene)|ensembl:ENSMUST00000156585(transcript)|ensembl:ENSMUST00000185355(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000972"(transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0001942"(hair follicle development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007399"(nervous system development)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0010669"(epithelial structure maintenance)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0021702"(cerebellar Purkinje cell differentiation)|go:"GO:0022607"(cellular component assembly)|go:"GO:0030154"(cell differentiation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030274"(LIM domain binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0031252"(cell leading edge)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034243"(regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043549"(regulation of kinase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0043973"(histone H3-K4 acetylation)|go:"GO:0045647"(negative regulation of erythrocyte differentiation)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046985"(positive regulation of hemoglobin biosynthetic process)|go:"GO:0048382"(mesendoderm development)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0060319"(primitive erythrocyte differentiation)|go:"GO:0060322"(head development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|rcsb pdb:4JCJ|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|rcsb pdb:6PTL|reactome:R-MMU-8939236|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1990907"(beta-catenin-TCF complex)|interpro:IPR029005|interpro:IPR030167|interpro:IPR041363|mint:P70662|rcsb pdb:1J2O|rcsb pdb:1M3V|rcsb pdb:1RUT|rcsb pdb:2JTN|rcsb pdb:2L6Y|rcsb pdb:2L6Z|rcsb pdb:2LXD|refseq:XP_011245459.1|refseq:NP_001106879.1|refseq:NP_034827.1|dip:DIP-42842N|mint:MINT-7010550(identity)	-	function:Binds to and activates the promoter of the alpha-glycoprotein gene, and synergistically enhances transcription from the prolactin promoter in cooperation with Pit-1|comment:mint	-	figure legend:T3|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2009/03/03	2014/10/16	rogid:8RmeAhxVDKESx4KdOUTVjo3YThE10090	rogid:TWjht9b9thCYJCr+CPgcUWJ4GN810090	intact-crc:1A91C8F790D55C37|rigid:jsLOVPLArowWZRn4LWufDyWw0Bo	false	binding-associated region:28-153(MINT-7010559)|tag:?-?(MINT-7010562)	binding-associated region:336-366(MINT-7010553)|mutation disrupting interaction:358-358(MINT-7010567)|tag:?-?(MINT-7010555)|mutation disrupting interaction:338-338(MINT-7010551)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P50481	uniprotkb:P70662	intact:EBI-7988290|uniprotkb:Q61801|uniprotkb:Q61800|intact:MINT-7009840|ensembl:ENSMUSP00000056822|uniprotkb:A2ALD9	intact:EBI-6272082|ensembl:ENSMUSP00000118546|ensembl:ENSMUSP00000139562|uniprotkb:O55204|uniprotkb:Q1EQX2|uniprotkb:Q71V68	psi-mi:lhx3_mouse(display_long)|uniprotkb:Lhx3(gene name)|psi-mi:Lhx3(display_short)|uniprotkb:Lim-3(gene name synonym)|uniprotkb:Lim3(gene name synonym)|uniprotkb:Plim(gene name synonym)|uniprotkb:Homeobox protein LIM-3(gene name synonym)|uniprotkb:Homeobox protein P-LIM(gene name synonym)	psi-mi:ldb1_mouse(display_long)|uniprotkb:Ldb1(gene name)|psi-mi:Ldb1(display_short)|uniprotkb:Nli(gene name synonym)|uniprotkb:Carboxyl-terminal LIM domain-binding protein 2(gene name synonym)|uniprotkb:LIM domain-binding factor CLIM2(gene name synonym)|uniprotkb:Nuclear LIM interactor(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Bhati et al. (2008)	pubmed:18583962|imex:IM-11672|mint:MINT-7009832|doi:10.1038/emboj.2008.123	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7988506|mint:MINT-7010574|imex:IM-11672-5	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001034742.1|refseq:NP_034841.2|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048839"(inner ear development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|interpro:IPR001356(Homeobox)|interpro:IPR001781(Zinc finger, LIM-type)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:P50481|rcsb pdb:2JTN|rcsb pdb:2RGT|ensembl:ENSMUSG00000026934(gene)|ensembl:ENSMUST00000054099(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001890"(placenta development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0021520"(spinal cord motor neuron cell fate specification)|go:"GO:0021521"(ventral spinal cord interneuron specification)|go:"GO:0021526"(medial motor column neuron differentiation)|go:"GO:0021527"(spinal cord association neuron differentiation)|go:"GO:0021983"(pituitary gland development)|go:"GO:0030154"(cell differentiation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030324"(lung development)|mint:MINT-7010576(identity)	ensembl:ENSMUSG00000025223(gene)|ensembl:ENSMUST00000156585(transcript)|ensembl:ENSMUST00000185355(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000972"(transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0001942"(hair follicle development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007399"(nervous system development)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0010669"(epithelial structure maintenance)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0021702"(cerebellar Purkinje cell differentiation)|go:"GO:0022607"(cellular component assembly)|go:"GO:0030154"(cell differentiation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030274"(LIM domain binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0031252"(cell leading edge)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034243"(regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043549"(regulation of kinase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0043973"(histone H3-K4 acetylation)|go:"GO:0045647"(negative regulation of erythrocyte differentiation)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046985"(positive regulation of hemoglobin biosynthetic process)|go:"GO:0048382"(mesendoderm development)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0060319"(primitive erythrocyte differentiation)|go:"GO:0060322"(head development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|rcsb pdb:4JCJ|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|rcsb pdb:6PTL|reactome:R-MMU-8939236|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1990907"(beta-catenin-TCF complex)|interpro:IPR029005|interpro:IPR030167|interpro:IPR041363|mint:P70662|rcsb pdb:1J2O|rcsb pdb:1M3V|rcsb pdb:1RUT|rcsb pdb:2JTN|rcsb pdb:2L6Y|rcsb pdb:2L6Z|rcsb pdb:2LXD|refseq:XP_011245459.1|refseq:NP_001106879.1|refseq:NP_034827.1|dip:DIP-42842N|mint:MINT-7010583(identity)	-	function:Binds to and activates the promoter of the alpha-glycoprotein gene, and synergistically enhances transcription from the prolactin promoter in cooperation with Pit-1|comment:mint	-	figure legend:T3|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2009/03/03	2014/10/16	rogid:8RmeAhxVDKESx4KdOUTVjo3YThE10090	rogid:TWjht9b9thCYJCr+CPgcUWJ4GN810090	intact-crc:3D8EBE5909649A3D|rigid:jsLOVPLArowWZRn4LWufDyWw0Bo	false	tag:?-?(MINT-7010577)|binding-associated region:28-153(MINT-7010579)	mutation disrupting interaction:358-358(MINT-7010584)|binding-associated region:336-366(MINT-7010588)|mutation disrupting interaction:344-344(MINT-7010590)|tag:?-?(MINT-7010586)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P50481	uniprotkb:P70662	intact:EBI-7988290|uniprotkb:Q61801|uniprotkb:Q61800|intact:MINT-7009840|ensembl:ENSMUSP00000056822|uniprotkb:A2ALD9	intact:EBI-6272082|ensembl:ENSMUSP00000118546|ensembl:ENSMUSP00000139562|uniprotkb:O55204|uniprotkb:Q1EQX2|uniprotkb:Q71V68	psi-mi:lhx3_mouse(display_long)|uniprotkb:Lhx3(gene name)|psi-mi:Lhx3(display_short)|uniprotkb:Lim-3(gene name synonym)|uniprotkb:Lim3(gene name synonym)|uniprotkb:Plim(gene name synonym)|uniprotkb:Homeobox protein LIM-3(gene name synonym)|uniprotkb:Homeobox protein P-LIM(gene name synonym)	psi-mi:ldb1_mouse(display_long)|uniprotkb:Ldb1(gene name)|psi-mi:Ldb1(display_short)|uniprotkb:Nli(gene name synonym)|uniprotkb:Carboxyl-terminal LIM domain-binding protein 2(gene name synonym)|uniprotkb:LIM domain-binding factor CLIM2(gene name synonym)|uniprotkb:Nuclear LIM interactor(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Bhati et al. (2008)	pubmed:18583962|imex:IM-11672|mint:MINT-7009832|doi:10.1038/emboj.2008.123	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7988574|mint:MINT-7010596|imex:IM-11672-6	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001034742.1|refseq:NP_034841.2|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048839"(inner ear development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|interpro:IPR001356(Homeobox)|interpro:IPR001781(Zinc finger, LIM-type)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:P50481|rcsb pdb:2JTN|rcsb pdb:2RGT|ensembl:ENSMUSG00000026934(gene)|ensembl:ENSMUST00000054099(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001890"(placenta development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0021520"(spinal cord motor neuron cell fate specification)|go:"GO:0021521"(ventral spinal cord interneuron specification)|go:"GO:0021526"(medial motor column neuron differentiation)|go:"GO:0021527"(spinal cord association neuron differentiation)|go:"GO:0021983"(pituitary gland development)|go:"GO:0030154"(cell differentiation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030324"(lung development)|mint:MINT-7010608(identity)	ensembl:ENSMUSG00000025223(gene)|ensembl:ENSMUST00000156585(transcript)|ensembl:ENSMUST00000185355(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000972"(transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0001942"(hair follicle development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007399"(nervous system development)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0010669"(epithelial structure maintenance)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0021702"(cerebellar Purkinje cell differentiation)|go:"GO:0022607"(cellular component assembly)|go:"GO:0030154"(cell differentiation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030274"(LIM domain binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0031252"(cell leading edge)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034243"(regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043549"(regulation of kinase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0043973"(histone H3-K4 acetylation)|go:"GO:0045647"(negative regulation of erythrocyte differentiation)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046985"(positive regulation of hemoglobin biosynthetic process)|go:"GO:0048382"(mesendoderm development)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0060319"(primitive erythrocyte differentiation)|go:"GO:0060322"(head development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|rcsb pdb:4JCJ|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|rcsb pdb:6PTL|reactome:R-MMU-8939236|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1990907"(beta-catenin-TCF complex)|interpro:IPR029005|interpro:IPR030167|interpro:IPR041363|mint:P70662|rcsb pdb:1J2O|rcsb pdb:1M3V|rcsb pdb:1RUT|rcsb pdb:2JTN|rcsb pdb:2L6Y|rcsb pdb:2L6Z|rcsb pdb:2LXD|refseq:XP_011245459.1|refseq:NP_001106879.1|refseq:NP_034827.1|dip:DIP-42842N|mint:MINT-7010598(identity)	-	function:Binds to and activates the promoter of the alpha-glycoprotein gene, and synergistically enhances transcription from the prolactin promoter in cooperation with Pit-1|comment:mint	-	figure legend:T3|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2009/03/03	2014/10/16	rogid:8RmeAhxVDKESx4KdOUTVjo3YThE10090	rogid:TWjht9b9thCYJCr+CPgcUWJ4GN810090	intact-crc:B024060649AF3EC9|rigid:jsLOVPLArowWZRn4LWufDyWw0Bo	false	tag:?-?(MINT-7010612)|binding-associated region:28-153(MINT-7010609)	mutation disrupting interaction:345-345(MINT-7010599)|mutation disrupting interaction:358-358(MINT-7010605)|binding-associated region:336-366(MINT-7010601)|tag:?-?(MINT-7010603)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P61372	uniprotkb:P70662	intact:EBI-7988215|uniprotkb:P47894|uniprotkb:Q812D8|uniprotkb:P20663|intact:MINT-4594016|ensembl:ENSMUSP00000044879	intact:EBI-6272082|ensembl:ENSMUSP00000118546|ensembl:ENSMUSP00000139562|uniprotkb:O55204|uniprotkb:Q1EQX2|uniprotkb:Q71V68	psi-mi:isl1_mouse(display_long)|uniprotkb:Isl1(gene name)|psi-mi:Isl1(display_short)	psi-mi:ldb1_mouse(display_long)|uniprotkb:Ldb1(gene name)|psi-mi:Ldb1(display_short)|uniprotkb:Nli(gene name synonym)|uniprotkb:Carboxyl-terminal LIM domain-binding protein 2(gene name synonym)|uniprotkb:LIM domain-binding factor CLIM2(gene name synonym)|uniprotkb:Nuclear LIM interactor(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Bhati et al. (2008)	pubmed:18583962|imex:IM-11672|mint:MINT-7009832|doi:10.1038/emboj.2008.123	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7988628|mint:MINT-7010618|imex:IM-11672-7	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067434.3|refseq:XP_006517596.1|ensembl:ENSMUSG00000042258(gene)|ensembl:ENSMUST00000036060(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0048935"(peripheral nervous system neuron development)|go:"GO:0048936"(peripheral nervous system neuron axonogenesis)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0060037"(pharyngeal system development)|go:"GO:0060379"(cardiac muscle cell myoblast differentiation)|go:"GO:0060384"(innervation)|go:"GO:0060413"(atrial septum morphogenesis)|go:"GO:0060913"(cardiac cell fate determination)|go:"GO:0060931"(sinoatrial node cell development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071385"(cellular response to glucocorticoid stimulus)|go:"GO:0071657"(positive regulation of granulocyte colony-stimulating factor production)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1901258"(positive regulation of macrophage colony-stimulating factor production)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR001356(Homeobox)|interpro:IPR001781(Zinc finger, LIM-type)|interpro:IPR009057(Homeodomain-like)|go:"GO:0048880"(sensory system development)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001755"(neural crest cell migration)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003139"(secondary heart field specification)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003215"(cardiac right ventricle morphogenesis)|go:"GO:0003266"(regulation of secondary heart field cardioblast proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0007409"(axonogenesis)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0021520"(spinal cord motor neuron cell fate specification)|go:"GO:0021522"(spinal cord motor neuron differentiation)|go:"GO:0021524"(visceral motor neuron differentiation)|go:"GO:0021559"(trigeminal nerve development)|go:"GO:0021983"(pituitary gland development)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0031016"(pancreas development)|go:"GO:0031103"(axon regeneration)|go:"GO:0031290"(retinal ganglion cell axon guidance)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0032725"(positive regulation of granulocyte macrophage colony-stimulating factor production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032730"(positive regulation of interleukin-1 alpha production)|go:"GO:0007507"(heart development)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0033147"(negative regulation of intracellular estrogen receptor signaling pathway)|mint:P61372|rcsb pdb:2RGT|rcsb pdb:4JCJ|interpro:IPR017970|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048665"(neuron fate specification)|go:"GO:0048762"(mesenchymal cell differentiation)|mint:MINT-7010628(identity)	ensembl:ENSMUSG00000025223(gene)|ensembl:ENSMUST00000156585(transcript)|ensembl:ENSMUST00000185355(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000972"(transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0001942"(hair follicle development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007399"(nervous system development)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0010669"(epithelial structure maintenance)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0021702"(cerebellar Purkinje cell differentiation)|go:"GO:0022607"(cellular component assembly)|go:"GO:0030154"(cell differentiation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030274"(LIM domain binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0031252"(cell leading edge)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034243"(regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043549"(regulation of kinase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0043973"(histone H3-K4 acetylation)|go:"GO:0045647"(negative regulation of erythrocyte differentiation)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046985"(positive regulation of hemoglobin biosynthetic process)|go:"GO:0048382"(mesendoderm development)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0060319"(primitive erythrocyte differentiation)|go:"GO:0060322"(head development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|rcsb pdb:4JCJ|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|rcsb pdb:6PTL|reactome:R-MMU-8939236|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1990907"(beta-catenin-TCF complex)|interpro:IPR029005|interpro:IPR030167|interpro:IPR041363|mint:P70662|rcsb pdb:1J2O|rcsb pdb:1M3V|rcsb pdb:1RUT|rcsb pdb:2JTN|rcsb pdb:2L6Y|rcsb pdb:2L6Z|rcsb pdb:2LXD|refseq:XP_011245459.1|refseq:NP_001106879.1|refseq:NP_034827.1|dip:DIP-42842N|mint:MINT-7010620(identity)	-	function:Binds to one of the cis-acting domain of the insulin gene enhancer|comment:mint	-	figure legend:T3|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2009/03/03	2014/10/16	rogid:1eir7wLzkoqlwl4AfQuBtjjiyd010090	rogid:TWjht9b9thCYJCr+CPgcUWJ4GN810090	intact-crc:D4173034799CB73F|rigid:kZeTgLVQhus2lDAe9lG4B43RHTY	false	binding-associated region:17-70(MINT-7010629)|tag:?-?(MINT-7010632)	binding-associated region:336-366(MINT-7010623)|tag:?-?(MINT-7010625)|mutation disrupting interaction:359-359(MINT-7010621)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P61372	uniprotkb:P70662	intact:EBI-7988215|uniprotkb:P47894|uniprotkb:Q812D8|uniprotkb:P20663|intact:MINT-4594016|ensembl:ENSMUSP00000044879	intact:EBI-6272082|ensembl:ENSMUSP00000118546|ensembl:ENSMUSP00000139562|uniprotkb:O55204|uniprotkb:Q1EQX2|uniprotkb:Q71V68	psi-mi:isl1_mouse(display_long)|uniprotkb:Isl1(gene name)|psi-mi:Isl1(display_short)	psi-mi:ldb1_mouse(display_long)|uniprotkb:Ldb1(gene name)|psi-mi:Ldb1(display_short)|uniprotkb:Nli(gene name synonym)|uniprotkb:Carboxyl-terminal LIM domain-binding protein 2(gene name synonym)|uniprotkb:LIM domain-binding factor CLIM2(gene name synonym)|uniprotkb:Nuclear LIM interactor(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Bhati et al. (2008)	pubmed:18583962|imex:IM-11672|mint:MINT-7009832|doi:10.1038/emboj.2008.123	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7988659|mint:MINT-7010640|imex:IM-11672-8	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067434.3|refseq:XP_006517596.1|ensembl:ENSMUSG00000042258(gene)|ensembl:ENSMUST00000036060(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0048935"(peripheral nervous system neuron development)|go:"GO:0048936"(peripheral nervous system neuron axonogenesis)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0060037"(pharyngeal system development)|go:"GO:0060379"(cardiac muscle cell myoblast differentiation)|go:"GO:0060384"(innervation)|go:"GO:0060413"(atrial septum morphogenesis)|go:"GO:0060913"(cardiac cell fate determination)|go:"GO:0060931"(sinoatrial node cell development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071385"(cellular response to glucocorticoid stimulus)|go:"GO:0071657"(positive regulation of granulocyte colony-stimulating factor production)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1901258"(positive regulation of macrophage colony-stimulating factor production)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR001356(Homeobox)|interpro:IPR001781(Zinc finger, LIM-type)|interpro:IPR009057(Homeodomain-like)|go:"GO:0048880"(sensory system development)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001755"(neural crest cell migration)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003139"(secondary heart field specification)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003215"(cardiac right ventricle morphogenesis)|go:"GO:0003266"(regulation of secondary heart field cardioblast proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0007409"(axonogenesis)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0021520"(spinal cord motor neuron cell fate specification)|go:"GO:0021522"(spinal cord motor neuron differentiation)|go:"GO:0021524"(visceral motor neuron differentiation)|go:"GO:0021559"(trigeminal nerve development)|go:"GO:0021983"(pituitary gland development)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0031016"(pancreas development)|go:"GO:0031103"(axon regeneration)|go:"GO:0031290"(retinal ganglion cell axon guidance)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0032725"(positive regulation of granulocyte macrophage colony-stimulating factor production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032730"(positive regulation of interleukin-1 alpha production)|go:"GO:0007507"(heart development)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0033147"(negative regulation of intracellular estrogen receptor signaling pathway)|mint:P61372|rcsb pdb:2RGT|rcsb pdb:4JCJ|interpro:IPR017970|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048665"(neuron fate specification)|go:"GO:0048762"(mesenchymal cell differentiation)|mint:MINT-7010642(identity)	ensembl:ENSMUSG00000025223(gene)|ensembl:ENSMUST00000156585(transcript)|ensembl:ENSMUST00000185355(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000972"(transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0001942"(hair follicle development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007399"(nervous system development)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0010669"(epithelial structure maintenance)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0021702"(cerebellar Purkinje cell differentiation)|go:"GO:0022607"(cellular component assembly)|go:"GO:0030154"(cell differentiation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030274"(LIM domain binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0031252"(cell leading edge)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034243"(regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043549"(regulation of kinase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0043973"(histone H3-K4 acetylation)|go:"GO:0045647"(negative regulation of erythrocyte differentiation)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046985"(positive regulation of hemoglobin biosynthetic process)|go:"GO:0048382"(mesendoderm development)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0060319"(primitive erythrocyte differentiation)|go:"GO:0060322"(head development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|rcsb pdb:4JCJ|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|rcsb pdb:6PTL|reactome:R-MMU-8939236|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1990907"(beta-catenin-TCF complex)|interpro:IPR029005|interpro:IPR030167|interpro:IPR041363|mint:P70662|rcsb pdb:1J2O|rcsb pdb:1M3V|rcsb pdb:1RUT|rcsb pdb:2JTN|rcsb pdb:2L6Y|rcsb pdb:2L6Z|rcsb pdb:2LXD|refseq:XP_011245459.1|refseq:NP_001106879.1|refseq:NP_034827.1|dip:DIP-42842N|mint:MINT-7010649(identity)	-	function:Binds to one of the cis-acting domain of the insulin gene enhancer|comment:mint	-	figure legend:T3|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2009/03/03	2014/10/16	rogid:1eir7wLzkoqlwl4AfQuBtjjiyd010090	rogid:TWjht9b9thCYJCr+CPgcUWJ4GN810090	intact-crc:2BD445451E89624A|rigid:kZeTgLVQhus2lDAe9lG4B43RHTY	false	binding-associated region:17-70(MINT-7010645)|tag:?-?(MINT-7010643)	mutation disrupting interaction:356-358(MINT-7010654)|tag:?-?(MINT-7010650)|binding-associated region:336-366(MINT-7010652)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P50481	uniprotkb:P61372	intact:EBI-7988290|uniprotkb:Q61801|uniprotkb:Q61800|intact:MINT-7009840|ensembl:ENSMUSP00000056822|uniprotkb:A2ALD9	intact:EBI-7988215|uniprotkb:P47894|uniprotkb:Q812D8|uniprotkb:P20663|intact:MINT-4594016|ensembl:ENSMUSP00000044879	psi-mi:lhx3_mouse(display_long)|uniprotkb:Lhx3(gene name)|psi-mi:Lhx3(display_short)|uniprotkb:Lim-3(gene name synonym)|uniprotkb:Lim3(gene name synonym)|uniprotkb:Plim(gene name synonym)|uniprotkb:Homeobox protein LIM-3(gene name synonym)|uniprotkb:Homeobox protein P-LIM(gene name synonym)	psi-mi:isl1_mouse(display_long)|uniprotkb:Isl1(gene name)|psi-mi:Isl1(display_short)	psi-mi:"MI:0018"(two hybrid)	Bhati et al. (2008)	pubmed:18583962|imex:IM-11672|mint:MINT-7009832|doi:10.1038/emboj.2008.123	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7988721|mint:MINT-7010684|imex:IM-11672-11	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001034742.1|refseq:NP_034841.2|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048839"(inner ear development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|interpro:IPR001356(Homeobox)|interpro:IPR001781(Zinc finger, LIM-type)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:P50481|rcsb pdb:2JTN|rcsb pdb:2RGT|ensembl:ENSMUSG00000026934(gene)|ensembl:ENSMUST00000054099(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001890"(placenta development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0021520"(spinal cord motor neuron cell fate specification)|go:"GO:0021521"(ventral spinal cord interneuron specification)|go:"GO:0021526"(medial motor column neuron differentiation)|go:"GO:0021527"(spinal cord association neuron differentiation)|go:"GO:0021983"(pituitary gland development)|go:"GO:0030154"(cell differentiation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030324"(lung development)|mint:MINT-7010686(identity)	refseq:NP_067434.3|refseq:XP_006517596.1|ensembl:ENSMUSG00000042258(gene)|ensembl:ENSMUST00000036060(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0048935"(peripheral nervous system neuron development)|go:"GO:0048936"(peripheral nervous system neuron axonogenesis)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0060037"(pharyngeal system development)|go:"GO:0060379"(cardiac muscle cell myoblast differentiation)|go:"GO:0060384"(innervation)|go:"GO:0060413"(atrial septum morphogenesis)|go:"GO:0060913"(cardiac cell fate determination)|go:"GO:0060931"(sinoatrial node cell development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071385"(cellular response to glucocorticoid stimulus)|go:"GO:0071657"(positive regulation of granulocyte colony-stimulating factor production)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1901258"(positive regulation of macrophage colony-stimulating factor production)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR001356(Homeobox)|interpro:IPR001781(Zinc finger, LIM-type)|interpro:IPR009057(Homeodomain-like)|go:"GO:0048880"(sensory system development)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001755"(neural crest cell migration)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003139"(secondary heart field specification)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003215"(cardiac right ventricle morphogenesis)|go:"GO:0003266"(regulation of secondary heart field cardioblast proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0007409"(axonogenesis)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0021520"(spinal cord motor neuron cell fate specification)|go:"GO:0021522"(spinal cord motor neuron differentiation)|go:"GO:0021524"(visceral motor neuron differentiation)|go:"GO:0021559"(trigeminal nerve development)|go:"GO:0021983"(pituitary gland development)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0031016"(pancreas development)|go:"GO:0031103"(axon regeneration)|go:"GO:0031290"(retinal ganglion cell axon guidance)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0032725"(positive regulation of granulocyte macrophage colony-stimulating factor production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032730"(positive regulation of interleukin-1 alpha production)|go:"GO:0007507"(heart development)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0033147"(negative regulation of intracellular estrogen receptor signaling pathway)|mint:P61372|rcsb pdb:2RGT|rcsb pdb:4JCJ|interpro:IPR017970|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048665"(neuron fate specification)|go:"GO:0048762"(mesenchymal cell differentiation)|mint:MINT-7010693(identity)	-	function:Binds to and activates the promoter of the alpha-glycoprotein gene, and synergistically enhances transcription from the prolactin promoter in cooperation with Pit-1|comment:mint	function:Binds to one of the cis-acting domain of the insulin gene enhancer|comment:mint	figure legend:T3|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2009/03/03	2014/10/16	rogid:8RmeAhxVDKESx4KdOUTVjo3YThE10090	rogid:1eir7wLzkoqlwl4AfQuBtjjiyd010090	intact-crc:087F493A629B970C|rigid:9Qx1kTIXB2PNLGoQ/JePSUvPNA8	false	binding-associated region:28-153(MINT-7010689)|tag:?-?(MINT-7010687)	mutation disrupting interaction:265-265(MINT-7010702)|binding-associated region:262-292(MINT-7010696)|tag:?-?(MINT-7010694)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P61372	uniprotkb:P70662	intact:EBI-7988215|uniprotkb:P47894|uniprotkb:Q812D8|uniprotkb:P20663|intact:MINT-4594016|ensembl:ENSMUSP00000044879	intact:EBI-6272082|ensembl:ENSMUSP00000118546|ensembl:ENSMUSP00000139562|uniprotkb:O55204|uniprotkb:Q1EQX2|uniprotkb:Q71V68	psi-mi:isl1_mouse(display_long)|uniprotkb:Isl1(gene name)|psi-mi:Isl1(display_short)	psi-mi:ldb1_mouse(display_long)|uniprotkb:Ldb1(gene name)|psi-mi:Ldb1(display_short)|uniprotkb:Nli(gene name synonym)|uniprotkb:Carboxyl-terminal LIM domain-binding protein 2(gene name synonym)|uniprotkb:LIM domain-binding factor CLIM2(gene name synonym)|uniprotkb:Nuclear LIM interactor(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Bhati et al. (2008)	pubmed:18583962|imex:IM-11672|mint:MINT-7009832|doi:10.1038/emboj.2008.123	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7988690|mint:MINT-7010660|imex:IM-11672-9	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067434.3|refseq:XP_006517596.1|ensembl:ENSMUSG00000042258(gene)|ensembl:ENSMUST00000036060(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0048935"(peripheral nervous system neuron development)|go:"GO:0048936"(peripheral nervous system neuron axonogenesis)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0060037"(pharyngeal system development)|go:"GO:0060379"(cardiac muscle cell myoblast differentiation)|go:"GO:0060384"(innervation)|go:"GO:0060413"(atrial septum morphogenesis)|go:"GO:0060913"(cardiac cell fate determination)|go:"GO:0060931"(sinoatrial node cell development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071385"(cellular response to glucocorticoid stimulus)|go:"GO:0071657"(positive regulation of granulocyte colony-stimulating factor production)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1901258"(positive regulation of macrophage colony-stimulating factor production)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR001356(Homeobox)|interpro:IPR001781(Zinc finger, LIM-type)|interpro:IPR009057(Homeodomain-like)|go:"GO:0048880"(sensory system development)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001755"(neural crest cell migration)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003139"(secondary heart field specification)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003215"(cardiac right ventricle morphogenesis)|go:"GO:0003266"(regulation of secondary heart field cardioblast proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0007409"(axonogenesis)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0021520"(spinal cord motor neuron cell fate specification)|go:"GO:0021522"(spinal cord motor neuron differentiation)|go:"GO:0021524"(visceral motor neuron differentiation)|go:"GO:0021559"(trigeminal nerve development)|go:"GO:0021983"(pituitary gland development)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0031016"(pancreas development)|go:"GO:0031103"(axon regeneration)|go:"GO:0031290"(retinal ganglion cell axon guidance)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0032725"(positive regulation of granulocyte macrophage colony-stimulating factor production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032730"(positive regulation of interleukin-1 alpha production)|go:"GO:0007507"(heart development)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0033147"(negative regulation of intracellular estrogen receptor signaling pathway)|mint:P61372|rcsb pdb:2RGT|rcsb pdb:4JCJ|interpro:IPR017970|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048665"(neuron fate specification)|go:"GO:0048762"(mesenchymal cell differentiation)|mint:MINT-7010670(identity)	ensembl:ENSMUSG00000025223(gene)|ensembl:ENSMUST00000156585(transcript)|ensembl:ENSMUST00000185355(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000972"(transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0001942"(hair follicle development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007399"(nervous system development)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0010669"(epithelial structure maintenance)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0021702"(cerebellar Purkinje cell differentiation)|go:"GO:0022607"(cellular component assembly)|go:"GO:0030154"(cell differentiation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030274"(LIM domain binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0031252"(cell leading edge)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034243"(regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043549"(regulation of kinase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0043973"(histone H3-K4 acetylation)|go:"GO:0045647"(negative regulation of erythrocyte differentiation)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046985"(positive regulation of hemoglobin biosynthetic process)|go:"GO:0048382"(mesendoderm development)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0060319"(primitive erythrocyte differentiation)|go:"GO:0060322"(head development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|rcsb pdb:4JCJ|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|rcsb pdb:6PTL|reactome:R-MMU-8939236|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1990907"(beta-catenin-TCF complex)|interpro:IPR029005|interpro:IPR030167|interpro:IPR041363|mint:P70662|rcsb pdb:1J2O|rcsb pdb:1M3V|rcsb pdb:1RUT|rcsb pdb:2JTN|rcsb pdb:2L6Y|rcsb pdb:2L6Z|rcsb pdb:2LXD|refseq:XP_011245459.1|refseq:NP_001106879.1|refseq:NP_034827.1|dip:DIP-42842N|mint:MINT-7010662(identity)	-	function:Binds to one of the cis-acting domain of the insulin gene enhancer|comment:mint	-	figure legend:T3|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2009/03/03	2014/10/16	rogid:1eir7wLzkoqlwl4AfQuBtjjiyd010090	rogid:TWjht9b9thCYJCr+CPgcUWJ4GN810090	intact-crc:E8F8A2E8645CFAEB|rigid:kZeTgLVQhus2lDAe9lG4B43RHTY	false	binding-associated region:17-70(MINT-7010671)|tag:?-?(MINT-7010674)	mutation decreasing interaction:359-361(MINT-7010663)|binding-associated region:336-366(MINT-7010665)|tag:?-?(MINT-7010667)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P61372	uniprotkb:P50481	intact:EBI-7988215|uniprotkb:P47894|uniprotkb:Q812D8|uniprotkb:P20663|intact:MINT-4594016|ensembl:ENSMUSP00000044879	intact:EBI-7988290|uniprotkb:Q61801|uniprotkb:Q61800|intact:MINT-7009840|ensembl:ENSMUSP00000056822|uniprotkb:A2ALD9	psi-mi:isl1_mouse(display_long)|uniprotkb:Isl1(gene name)|psi-mi:Isl1(display_short)	psi-mi:lhx3_mouse(display_long)|uniprotkb:Lhx3(gene name)|psi-mi:Lhx3(display_short)|uniprotkb:Lim-3(gene name synonym)|uniprotkb:Lim3(gene name synonym)|uniprotkb:Plim(gene name synonym)|uniprotkb:Homeobox protein LIM-3(gene name synonym)|uniprotkb:Homeobox protein P-LIM(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Bhati et al. (2008)	pubmed:18583962|imex:IM-11672|mint:MINT-7009832|doi:10.1038/emboj.2008.123	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7988753|mint:MINT-7010709|imex:IM-11672-12	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067434.3|refseq:XP_006517596.1|ensembl:ENSMUSG00000042258(gene)|ensembl:ENSMUST00000036060(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0048935"(peripheral nervous system neuron development)|go:"GO:0048936"(peripheral nervous system neuron axonogenesis)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0060037"(pharyngeal system development)|go:"GO:0060379"(cardiac muscle cell myoblast differentiation)|go:"GO:0060384"(innervation)|go:"GO:0060413"(atrial septum morphogenesis)|go:"GO:0060913"(cardiac cell fate determination)|go:"GO:0060931"(sinoatrial node cell development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071385"(cellular response to glucocorticoid stimulus)|go:"GO:0071657"(positive regulation of granulocyte colony-stimulating factor production)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1901258"(positive regulation of macrophage colony-stimulating factor production)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR001356(Homeobox)|interpro:IPR001781(Zinc finger, LIM-type)|interpro:IPR009057(Homeodomain-like)|go:"GO:0048880"(sensory system development)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001755"(neural crest cell migration)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003139"(secondary heart field specification)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003215"(cardiac right ventricle morphogenesis)|go:"GO:0003266"(regulation of secondary heart field cardioblast proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0007409"(axonogenesis)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0021520"(spinal cord motor neuron cell fate specification)|go:"GO:0021522"(spinal cord motor neuron differentiation)|go:"GO:0021524"(visceral motor neuron differentiation)|go:"GO:0021559"(trigeminal nerve development)|go:"GO:0021983"(pituitary gland development)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0031016"(pancreas development)|go:"GO:0031103"(axon regeneration)|go:"GO:0031290"(retinal ganglion cell axon guidance)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0032725"(positive regulation of granulocyte macrophage colony-stimulating factor production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032730"(positive regulation of interleukin-1 alpha production)|go:"GO:0007507"(heart development)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0033147"(negative regulation of intracellular estrogen receptor signaling pathway)|mint:P61372|rcsb pdb:2RGT|rcsb pdb:4JCJ|interpro:IPR017970|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048665"(neuron fate specification)|go:"GO:0048762"(mesenchymal cell differentiation)|mint:MINT-7010711(identity)	refseq:NP_001034742.1|refseq:NP_034841.2|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048839"(inner ear development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|interpro:IPR001356(Homeobox)|interpro:IPR001781(Zinc finger, LIM-type)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:P50481|rcsb pdb:2JTN|rcsb pdb:2RGT|ensembl:ENSMUSG00000026934(gene)|ensembl:ENSMUST00000054099(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001890"(placenta development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0021520"(spinal cord motor neuron cell fate specification)|go:"GO:0021521"(ventral spinal cord interneuron specification)|go:"GO:0021526"(medial motor column neuron differentiation)|go:"GO:0021527"(spinal cord association neuron differentiation)|go:"GO:0021983"(pituitary gland development)|go:"GO:0030154"(cell differentiation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030324"(lung development)|mint:MINT-7010719(identity)	-	function:Binds to one of the cis-acting domain of the insulin gene enhancer|comment:mint	function:Binds to and activates the promoter of the alpha-glycoprotein gene, and synergistically enhances transcription from the prolactin promoter in cooperation with Pit-1|comment:mint	figure legend:T3|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2009/03/03	2014/10/16	rogid:1eir7wLzkoqlwl4AfQuBtjjiyd010090	rogid:8RmeAhxVDKESx4KdOUTVjo3YThE10090	intact-crc:4E1CD2D834F35B4A|rigid:9Qx1kTIXB2PNLGoQ/JePSUvPNA8	false	mutation disrupting interaction:267-267(MINT-7010751)|binding-associated region:262-292(MINT-7010714)|mutation disrupting interaction:265-265(MINT-7010712)|tag:?-?(MINT-7010716)|mutation disrupting interaction:266-266(MINT-7010748)	binding-associated region:28-153(MINT-7010720)|tag:?-?(MINT-7010723)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P61372	uniprotkb:P50481	intact:EBI-7988215|uniprotkb:P47894|uniprotkb:Q812D8|uniprotkb:P20663|intact:MINT-4594016|ensembl:ENSMUSP00000044879	intact:EBI-7988290|uniprotkb:Q61801|uniprotkb:Q61800|intact:MINT-7009840|ensembl:ENSMUSP00000056822|uniprotkb:A2ALD9	psi-mi:isl1_mouse(display_long)|uniprotkb:Isl1(gene name)|psi-mi:Isl1(display_short)	psi-mi:lhx3_mouse(display_long)|uniprotkb:Lhx3(gene name)|psi-mi:Lhx3(display_short)|uniprotkb:Lim-3(gene name synonym)|uniprotkb:Lim3(gene name synonym)|uniprotkb:Plim(gene name synonym)|uniprotkb:Homeobox protein LIM-3(gene name synonym)|uniprotkb:Homeobox protein P-LIM(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Bhati et al. (2008)	pubmed:18583962|imex:IM-11672|mint:MINT-7009832|doi:10.1038/emboj.2008.123	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7988849|mint:MINT-7010729|imex:IM-11672-13	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067434.3|refseq:XP_006517596.1|ensembl:ENSMUSG00000042258(gene)|ensembl:ENSMUST00000036060(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0048935"(peripheral nervous system neuron development)|go:"GO:0048936"(peripheral nervous system neuron axonogenesis)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0060037"(pharyngeal system development)|go:"GO:0060379"(cardiac muscle cell myoblast differentiation)|go:"GO:0060384"(innervation)|go:"GO:0060413"(atrial septum morphogenesis)|go:"GO:0060913"(cardiac cell fate determination)|go:"GO:0060931"(sinoatrial node cell development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071385"(cellular response to glucocorticoid stimulus)|go:"GO:0071657"(positive regulation of granulocyte colony-stimulating factor production)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1901258"(positive regulation of macrophage colony-stimulating factor production)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR001356(Homeobox)|interpro:IPR001781(Zinc finger, LIM-type)|interpro:IPR009057(Homeodomain-like)|go:"GO:0048880"(sensory system development)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001755"(neural crest cell migration)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003139"(secondary heart field specification)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003215"(cardiac right ventricle morphogenesis)|go:"GO:0003266"(regulation of secondary heart field cardioblast proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0007409"(axonogenesis)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0021520"(spinal cord motor neuron cell fate specification)|go:"GO:0021522"(spinal cord motor neuron differentiation)|go:"GO:0021524"(visceral motor neuron differentiation)|go:"GO:0021559"(trigeminal nerve development)|go:"GO:0021983"(pituitary gland development)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0031016"(pancreas development)|go:"GO:0031103"(axon regeneration)|go:"GO:0031290"(retinal ganglion cell axon guidance)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0032725"(positive regulation of granulocyte macrophage colony-stimulating factor production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032730"(positive regulation of interleukin-1 alpha production)|go:"GO:0007507"(heart development)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0033147"(negative regulation of intracellular estrogen receptor signaling pathway)|mint:P61372|rcsb pdb:2RGT|rcsb pdb:4JCJ|interpro:IPR017970|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048665"(neuron fate specification)|go:"GO:0048762"(mesenchymal cell differentiation)|mint:MINT-7010738(identity)	refseq:NP_001034742.1|refseq:NP_034841.2|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048839"(inner ear development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|interpro:IPR001356(Homeobox)|interpro:IPR001781(Zinc finger, LIM-type)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:P50481|rcsb pdb:2JTN|rcsb pdb:2RGT|ensembl:ENSMUSG00000026934(gene)|ensembl:ENSMUST00000054099(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001890"(placenta development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0021520"(spinal cord motor neuron cell fate specification)|go:"GO:0021521"(ventral spinal cord interneuron specification)|go:"GO:0021526"(medial motor column neuron differentiation)|go:"GO:0021527"(spinal cord association neuron differentiation)|go:"GO:0021983"(pituitary gland development)|go:"GO:0030154"(cell differentiation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030324"(lung development)|mint:MINT-7010731(identity)	-	function:Binds to one of the cis-acting domain of the insulin gene enhancer|comment:mint	function:Binds to and activates the promoter of the alpha-glycoprotein gene, and synergistically enhances transcription from the prolactin promoter in cooperation with Pit-1|comment:mint	figure legend:T3|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2009/03/03	2014/10/16	rogid:1eir7wLzkoqlwl4AfQuBtjjiyd010090	rogid:8RmeAhxVDKESx4KdOUTVjo3YThE10090	intact-crc:7E96F46D97D61018|rigid:9Qx1kTIXB2PNLGoQ/JePSUvPNA8	false	binding-associated region:262-292(MINT-7010741)|tag:?-?(MINT-7010739)|mutation disrupting interaction:267-267(MINT-7010743)	binding-associated region:28-153(MINT-7010734)|tag:?-?(MINT-7010732)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P61372	uniprotkb:P50481	intact:EBI-7988215|uniprotkb:P47894|uniprotkb:Q812D8|uniprotkb:P20663|intact:MINT-4594016|ensembl:ENSMUSP00000044879	intact:EBI-7988290|uniprotkb:Q61801|uniprotkb:Q61800|intact:MINT-7009840|ensembl:ENSMUSP00000056822|uniprotkb:A2ALD9	psi-mi:isl1_mouse(display_long)|uniprotkb:Isl1(gene name)|psi-mi:Isl1(display_short)	psi-mi:lhx3_mouse(display_long)|uniprotkb:Lhx3(gene name)|psi-mi:Lhx3(display_short)|uniprotkb:Lim-3(gene name synonym)|uniprotkb:Lim3(gene name synonym)|uniprotkb:Plim(gene name synonym)|uniprotkb:Homeobox protein LIM-3(gene name synonym)|uniprotkb:Homeobox protein P-LIM(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Bhati et al. (2008)	pubmed:18583962|imex:IM-11672|mint:MINT-7009832|doi:10.1038/emboj.2008.123	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7988928|mint:MINT-7010755|imex:IM-11672-14	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067434.3|refseq:XP_006517596.1|ensembl:ENSMUSG00000042258(gene)|ensembl:ENSMUST00000036060(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0048935"(peripheral nervous system neuron development)|go:"GO:0048936"(peripheral nervous system neuron axonogenesis)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0060037"(pharyngeal system development)|go:"GO:0060379"(cardiac muscle cell myoblast differentiation)|go:"GO:0060384"(innervation)|go:"GO:0060413"(atrial septum morphogenesis)|go:"GO:0060913"(cardiac cell fate determination)|go:"GO:0060931"(sinoatrial node cell development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071385"(cellular response to glucocorticoid stimulus)|go:"GO:0071657"(positive regulation of granulocyte colony-stimulating factor production)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1901258"(positive regulation of macrophage colony-stimulating factor production)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR001356(Homeobox)|interpro:IPR001781(Zinc finger, LIM-type)|interpro:IPR009057(Homeodomain-like)|go:"GO:0048880"(sensory system development)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001755"(neural crest cell migration)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003139"(secondary heart field specification)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003215"(cardiac right ventricle morphogenesis)|go:"GO:0003266"(regulation of secondary heart field cardioblast proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0007409"(axonogenesis)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0021520"(spinal cord motor neuron cell fate specification)|go:"GO:0021522"(spinal cord motor neuron differentiation)|go:"GO:0021524"(visceral motor neuron differentiation)|go:"GO:0021559"(trigeminal nerve development)|go:"GO:0021983"(pituitary gland development)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0031016"(pancreas development)|go:"GO:0031103"(axon regeneration)|go:"GO:0031290"(retinal ganglion cell axon guidance)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0032725"(positive regulation of granulocyte macrophage colony-stimulating factor production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032730"(positive regulation of interleukin-1 alpha production)|go:"GO:0007507"(heart development)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0033147"(negative regulation of intracellular estrogen receptor signaling pathway)|mint:P61372|rcsb pdb:2RGT|rcsb pdb:4JCJ|interpro:IPR017970|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048665"(neuron fate specification)|go:"GO:0048762"(mesenchymal cell differentiation)|mint:MINT-7010764(identity)	refseq:NP_001034742.1|refseq:NP_034841.2|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048839"(inner ear development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|interpro:IPR001356(Homeobox)|interpro:IPR001781(Zinc finger, LIM-type)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:P50481|rcsb pdb:2JTN|rcsb pdb:2RGT|ensembl:ENSMUSG00000026934(gene)|ensembl:ENSMUST00000054099(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001890"(placenta development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0021520"(spinal cord motor neuron cell fate specification)|go:"GO:0021521"(ventral spinal cord interneuron specification)|go:"GO:0021526"(medial motor column neuron differentiation)|go:"GO:0021527"(spinal cord association neuron differentiation)|go:"GO:0021983"(pituitary gland development)|go:"GO:0030154"(cell differentiation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030324"(lung development)|mint:MINT-7010757(identity)	-	function:Binds to one of the cis-acting domain of the insulin gene enhancer|comment:mint	function:Binds to and activates the promoter of the alpha-glycoprotein gene, and synergistically enhances transcription from the prolactin promoter in cooperation with Pit-1|comment:mint	figure legend:T3|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2009/03/03	2014/10/16	rogid:1eir7wLzkoqlwl4AfQuBtjjiyd010090	rogid:8RmeAhxVDKESx4KdOUTVjo3YThE10090	intact-crc:38BDD84CB33BD19E|rigid:9Qx1kTIXB2PNLGoQ/JePSUvPNA8	false	mutation disrupting interaction:266-266(MINT-7010767)|binding-associated region:262-292(MINT-7010773)|tag:?-?(MINT-7010771)|mutation disrupting interaction:265-265(MINT-7010769)|mutation disrupting interaction:267-267(MINT-7010765)	tag:?-?(MINT-7010758)|binding-associated region:28-153(MINT-7010760)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P50481	uniprotkb:P61372	intact:EBI-7988290|uniprotkb:Q61801|uniprotkb:Q61800|intact:MINT-7009840|ensembl:ENSMUSP00000056822|uniprotkb:A2ALD9	intact:EBI-7988215|uniprotkb:P47894|uniprotkb:Q812D8|uniprotkb:P20663|intact:MINT-4594016|ensembl:ENSMUSP00000044879	psi-mi:lhx3_mouse(display_long)|uniprotkb:Lhx3(gene name)|psi-mi:Lhx3(display_short)|uniprotkb:Lim-3(gene name synonym)|uniprotkb:Lim3(gene name synonym)|uniprotkb:Plim(gene name synonym)|uniprotkb:Homeobox protein LIM-3(gene name synonym)|uniprotkb:Homeobox protein P-LIM(gene name synonym)	psi-mi:isl1_mouse(display_long)|uniprotkb:Isl1(gene name)|psi-mi:Isl1(display_short)	psi-mi:"MI:0018"(two hybrid)	Bhati et al. (2008)	pubmed:18583962|imex:IM-11672|mint:MINT-7009832|doi:10.1038/emboj.2008.123	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7989088|mint:MINT-7010823|imex:IM-11672-17	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001034742.1|refseq:NP_034841.2|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048839"(inner ear development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|interpro:IPR001356(Homeobox)|interpro:IPR001781(Zinc finger, LIM-type)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:P50481|rcsb pdb:2JTN|rcsb pdb:2RGT|ensembl:ENSMUSG00000026934(gene)|ensembl:ENSMUST00000054099(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001890"(placenta development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0021520"(spinal cord motor neuron cell fate specification)|go:"GO:0021521"(ventral spinal cord interneuron specification)|go:"GO:0021526"(medial motor column neuron differentiation)|go:"GO:0021527"(spinal cord association neuron differentiation)|go:"GO:0021983"(pituitary gland development)|go:"GO:0030154"(cell differentiation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030324"(lung development)|mint:MINT-7010825(identity)	refseq:NP_067434.3|refseq:XP_006517596.1|ensembl:ENSMUSG00000042258(gene)|ensembl:ENSMUST00000036060(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0048935"(peripheral nervous system neuron development)|go:"GO:0048936"(peripheral nervous system neuron axonogenesis)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0060037"(pharyngeal system development)|go:"GO:0060379"(cardiac muscle cell myoblast differentiation)|go:"GO:0060384"(innervation)|go:"GO:0060413"(atrial septum morphogenesis)|go:"GO:0060913"(cardiac cell fate determination)|go:"GO:0060931"(sinoatrial node cell development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071385"(cellular response to glucocorticoid stimulus)|go:"GO:0071657"(positive regulation of granulocyte colony-stimulating factor production)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1901258"(positive regulation of macrophage colony-stimulating factor production)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR001356(Homeobox)|interpro:IPR001781(Zinc finger, LIM-type)|interpro:IPR009057(Homeodomain-like)|go:"GO:0048880"(sensory system development)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001755"(neural crest cell migration)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003139"(secondary heart field specification)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003215"(cardiac right ventricle morphogenesis)|go:"GO:0003266"(regulation of secondary heart field cardioblast proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0007409"(axonogenesis)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0021520"(spinal cord motor neuron cell fate specification)|go:"GO:0021522"(spinal cord motor neuron differentiation)|go:"GO:0021524"(visceral motor neuron differentiation)|go:"GO:0021559"(trigeminal nerve development)|go:"GO:0021983"(pituitary gland development)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0031016"(pancreas development)|go:"GO:0031103"(axon regeneration)|go:"GO:0031290"(retinal ganglion cell axon guidance)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0032725"(positive regulation of granulocyte macrophage colony-stimulating factor production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032730"(positive regulation of interleukin-1 alpha production)|go:"GO:0007507"(heart development)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0033147"(negative regulation of intracellular estrogen receptor signaling pathway)|mint:P61372|rcsb pdb:2RGT|rcsb pdb:4JCJ|interpro:IPR017970|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048665"(neuron fate specification)|go:"GO:0048762"(mesenchymal cell differentiation)|mint:MINT-7010832(identity)	-	function:Binds to and activates the promoter of the alpha-glycoprotein gene, and synergistically enhances transcription from the prolactin promoter in cooperation with Pit-1|comment:mint	function:Binds to one of the cis-acting domain of the insulin gene enhancer|comment:mint	figure legend:T3|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:559292(yeast)|taxid:559292(Saccharomyces cerevisiae)	-	2009/03/03	2014/10/16	rogid:8RmeAhxVDKESx4KdOUTVjo3YThE10090	rogid:1eir7wLzkoqlwl4AfQuBtjjiyd010090	intact-crc:6478A369ADA4D2C5|rigid:9Qx1kTIXB2PNLGoQ/JePSUvPNA8	false	tag:?-?(MINT-7010826)|binding-associated region:28-153(MINT-7010828)	binding-associated region:262-292(MINT-7010835)|tag:?-?(MINT-7010833)|mutation disrupting interaction:265-265(MINT-7010837)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P50481	uniprotkb:P61372	intact:EBI-7988290|uniprotkb:Q61801|uniprotkb:Q61800|intact:MINT-7009840|ensembl:ENSMUSP00000056822|uniprotkb:A2ALD9	intact:EBI-7988215|uniprotkb:P47894|uniprotkb:Q812D8|uniprotkb:P20663|intact:MINT-4594016|ensembl:ENSMUSP00000044879	psi-mi:lhx3_mouse(display_long)|uniprotkb:Lhx3(gene name)|psi-mi:Lhx3(display_short)|uniprotkb:Lim-3(gene name synonym)|uniprotkb:Lim3(gene name synonym)|uniprotkb:Plim(gene name synonym)|uniprotkb:Homeobox protein LIM-3(gene name synonym)|uniprotkb:Homeobox protein P-LIM(gene name synonym)	psi-mi:isl1_mouse(display_long)|uniprotkb:Isl1(gene name)|psi-mi:Isl1(display_short)	psi-mi:"MI:0114"(x-ray crystallography)	Bhati et al. (2008)	pubmed:18583962|imex:IM-11672|mint:MINT-7009832|doi:10.1038/emboj.2008.123	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7989129|mint:MINT-7009875|imex:IM-11672-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001034742.1|refseq:NP_034841.2|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048839"(inner ear development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|interpro:IPR001356(Homeobox)|interpro:IPR001781(Zinc finger, LIM-type)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:P50481|rcsb pdb:2JTN|rcsb pdb:2RGT|ensembl:ENSMUSG00000026934(gene)|ensembl:ENSMUST00000054099(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001890"(placenta development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0021520"(spinal cord motor neuron cell fate specification)|go:"GO:0021521"(ventral spinal cord interneuron specification)|go:"GO:0021526"(medial motor column neuron differentiation)|go:"GO:0021527"(spinal cord association neuron differentiation)|go:"GO:0021983"(pituitary gland development)|go:"GO:0030154"(cell differentiation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030324"(lung development)|mint:MINT-7009877(identity)	refseq:NP_067434.3|refseq:XP_006517596.1|ensembl:ENSMUSG00000042258(gene)|ensembl:ENSMUST00000036060(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0048935"(peripheral nervous system neuron development)|go:"GO:0048936"(peripheral nervous system neuron axonogenesis)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0060037"(pharyngeal system development)|go:"GO:0060379"(cardiac muscle cell myoblast differentiation)|go:"GO:0060384"(innervation)|go:"GO:0060413"(atrial septum morphogenesis)|go:"GO:0060913"(cardiac cell fate determination)|go:"GO:0060931"(sinoatrial node cell development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071385"(cellular response to glucocorticoid stimulus)|go:"GO:0071657"(positive regulation of granulocyte colony-stimulating factor production)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1901258"(positive regulation of macrophage colony-stimulating factor production)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR001356(Homeobox)|interpro:IPR001781(Zinc finger, LIM-type)|interpro:IPR009057(Homeodomain-like)|go:"GO:0048880"(sensory system development)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001755"(neural crest cell migration)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003139"(secondary heart field specification)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003215"(cardiac right ventricle morphogenesis)|go:"GO:0003266"(regulation of secondary heart field cardioblast proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0007409"(axonogenesis)|go:"GO:0010575"(positive regulation of vascular endothelial growth factor production)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0021520"(spinal cord motor neuron cell fate specification)|go:"GO:0021522"(spinal cord motor neuron differentiation)|go:"GO:0021524"(visceral motor neuron differentiation)|go:"GO:0021559"(trigeminal nerve development)|go:"GO:0021983"(pituitary gland development)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0031016"(pancreas development)|go:"GO:0031103"(axon regeneration)|go:"GO:0031290"(retinal ganglion cell axon guidance)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0032725"(positive regulation of granulocyte macrophage colony-stimulating factor production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032730"(positive regulation of interleukin-1 alpha production)|go:"GO:0007507"(heart development)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0033147"(negative regulation of intracellular estrogen receptor signaling pathway)|mint:P61372|rcsb pdb:2RGT|rcsb pdb:4JCJ|interpro:IPR017970|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048663"(neuron fate commitment)|go:"GO:0048665"(neuron fate specification)|go:"GO:0048762"(mesenchymal cell differentiation)|mint:MINT-7009878(identity)	-	function:Binds to and activates the promoter of the alpha-glycoprotein gene, and synergistically enhances transcription from the prolactin promoter in cooperation with Pit-1|comment:mint	function:Binds to one of the cis-acting domain of the insulin gene enhancer|comment:mint	figure legend:t2|comment:homomint|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/03/03	2014/10/16	rogid:8RmeAhxVDKESx4KdOUTVjo3YThE10090	rogid:1eir7wLzkoqlwl4AfQuBtjjiyd010090	intact-crc:6B7AA2DCD6061AFA|rigid:9Qx1kTIXB2PNLGoQ/JePSUvPNA8	false	binding-associated region:28-153(MINT-7009899)	binding-associated region:262-291(MINT-7009895)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P50481	uniprotkb:P70662	intact:EBI-7988290|uniprotkb:Q61801|uniprotkb:Q61800|intact:MINT-7009840|ensembl:ENSMUSP00000056822|uniprotkb:A2ALD9	intact:EBI-6272082|ensembl:ENSMUSP00000118546|ensembl:ENSMUSP00000139562|uniprotkb:O55204|uniprotkb:Q1EQX2|uniprotkb:Q71V68	psi-mi:lhx3_mouse(display_long)|uniprotkb:Lhx3(gene name)|psi-mi:Lhx3(display_short)|uniprotkb:Lim-3(gene name synonym)|uniprotkb:Lim3(gene name synonym)|uniprotkb:Plim(gene name synonym)|uniprotkb:Homeobox protein LIM-3(gene name synonym)|uniprotkb:Homeobox protein P-LIM(gene name synonym)	psi-mi:ldb1_mouse(display_long)|uniprotkb:Ldb1(gene name)|psi-mi:Ldb1(display_short)|uniprotkb:Nli(gene name synonym)|uniprotkb:Carboxyl-terminal LIM domain-binding protein 2(gene name synonym)|uniprotkb:LIM domain-binding factor CLIM2(gene name synonym)|uniprotkb:Nuclear LIM interactor(gene name synonym)	psi-mi:"MI:0077"(nuclear magnetic resonance)	Bhati et al. (2008)	pubmed:18583962|imex:IM-11672|mint:MINT-7009832|doi:10.1038/emboj.2008.123	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7989159|mint:MINT-7009879|imex:IM-11672-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0497"(neutral component)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001034742.1|refseq:NP_034841.2|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048839"(inner ear development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|interpro:IPR001356(Homeobox)|interpro:IPR001781(Zinc finger, LIM-type)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|mint:P50481|rcsb pdb:2JTN|rcsb pdb:2RGT|ensembl:ENSMUSG00000026934(gene)|ensembl:ENSMUST00000054099(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001890"(placenta development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0021520"(spinal cord motor neuron cell fate specification)|go:"GO:0021521"(ventral spinal cord interneuron specification)|go:"GO:0021526"(medial motor column neuron differentiation)|go:"GO:0021527"(spinal cord association neuron differentiation)|go:"GO:0021983"(pituitary gland development)|go:"GO:0030154"(cell differentiation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030324"(lung development)|mint:MINT-7009881(identity)	ensembl:ENSMUSG00000025223(gene)|ensembl:ENSMUST00000156585(transcript)|ensembl:ENSMUST00000185355(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000972"(transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0001942"(hair follicle development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0007399"(nervous system development)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0010669"(epithelial structure maintenance)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0021549"(cerebellum development)|go:"GO:0021702"(cerebellar Purkinje cell differentiation)|go:"GO:0022607"(cellular component assembly)|go:"GO:0030154"(cell differentiation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030274"(LIM domain binding)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0031252"(cell leading edge)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034243"(regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043549"(regulation of kinase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0043973"(histone H3-K4 acetylation)|go:"GO:0045647"(negative regulation of erythrocyte differentiation)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046985"(positive regulation of hemoglobin biosynthetic process)|go:"GO:0048382"(mesendoderm development)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0060319"(primitive erythrocyte differentiation)|go:"GO:0060322"(head development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|rcsb pdb:4JCJ|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|rcsb pdb:6PTL|reactome:R-MMU-8939236|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1990907"(beta-catenin-TCF complex)|interpro:IPR029005|interpro:IPR030167|interpro:IPR041363|mint:P70662|rcsb pdb:1J2O|rcsb pdb:1M3V|rcsb pdb:1RUT|rcsb pdb:2JTN|rcsb pdb:2L6Y|rcsb pdb:2L6Z|rcsb pdb:2LXD|refseq:XP_011245459.1|refseq:NP_001106879.1|refseq:NP_034827.1|dip:DIP-42842N|mint:MINT-7009882(identity)	-	function:Binds to and activates the promoter of the alpha-glycoprotein gene, and synergistically enhances transcription from the prolactin promoter in cooperation with Pit-1|comment:mint	-	figure legend:F2|comment:mint|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/03/03	2014/10/16	rogid:8RmeAhxVDKESx4KdOUTVjo3YThE10090	rogid:TWjht9b9thCYJCr+CPgcUWJ4GN810090	intact-crc:A0E76DAD5641C4D2|rigid:jsLOVPLArowWZRn4LWufDyWw0Bo	false	binding-associated region:28-153(MINT-7009910)	binding-associated region:295-340(MINT-7009906)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)