#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P61585 uniprotkb:Q5W5U3 intact:EBI-7634751|ensembl:ENSBTAP00000005600|uniprotkb:Q3ZC72|intact:MINT-139651|uniprotkb:Q9UEJ4|uniprotkb:P06749 intact:EBI-7634824|uniprotkb:F1MIQ6|intact:MINT-6825155 psi-mi:rhoa_bovin(display_long)|uniprotkb:RHOA(gene name)|psi-mi:RHOA(display_short)|uniprotkb:ARHA(gene name synonym)|uniprotkb:RHO12(gene name synonym)|uniprotkb:Gb(gene name synonym)|uniprotkb:p21(gene name synonym) psi-mi:q5w5u3_bovin(display_long)|uniprotkb:HK1(gene name)|psi-mi:HK1(display_short) psi-mi:"MI:0019"(coimmunoprecipitation) Fiedler et al. (2008) pubmed:17928627|mint:MINT-6826213|doi:10.1095/biolreprod.107.062943 taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)") taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)") psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-7634819|mint:MINT-6826222 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSBTAG00000004279(gene)|ensembl:ENSBTAT00000005600(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001998"(angiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure)|go:"GO:0002363"(alpha-beta T cell lineage commitment)|go:"GO:0003100"(regulation of systemic arterial blood pressure by endothelin)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007015"(actin filament organization)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010812"(negative regulation of cell-substrate adhesion)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0016477"(cell migration)|go:"GO:0017022"(myosin binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021795"(cerebral cortex cell migration)|go:"GO:0021861"(forebrain radial glial cell differentiation)|go:"GO:0030027"(lamellipodium)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030496"(midbody)|go:"GO:0030521"(androgen receptor signaling pathway)|go:"GO:0030865"(cortical cytoskeleton organization)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0033144"(negative regulation of intracellular steroid hormone receptor signaling pathway)|go:"GO:0033688"(regulation of osteoblast proliferation)|go:"GO:0034329"(cell junction assembly)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035385"(Roundabout signaling pathway)|go:"GO:0036089"(cleavage furrow formation)|go:"GO:0038027"(apolipoprotein A-I-mediated signaling pathway)|go:"GO:0042476"(odontogenesis)|go:"GO:0042995"(cell projection)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0043197"(dendritic spine)|go:"GO:0043296"(apical junction complex)|go:"GO:0043297"(apical junction assembly)|go:"GO:0043366"(beta selection)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0043931"(ossification involved in bone maturation)|go:"GO:0044319"(wound healing, spreading of cells)|go:"GO:0045198"(establishment of epithelial cell apical/basal polarity)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0046638"(positive regulation of alpha-beta T cell differentiation)|go:"GO:0050919"(negative chemotaxis)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0060193"(positive regulation of lipase activity)|go:"GO:0061383"(trabecula morphogenesis)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:0090324"(negative regulation of oxidative phosphorylation)|go:"GO:0097498"(endothelial tube lumen extension)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902766"(skeletal muscle satellite cell migration)|go:"GO:1903427"(negative regulation of reactive oxygen species biosynthetic process)|go:"GO:1903673"(mitotic cleavage furrow formation)|go:"GO:1904695"(positive regulation of vascular associated smooth muscle contraction)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000177"(regulation of neural precursor cell proliferation)|go:"GO:2000406"(positive regulation of T cell migration)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P61585|reactome:R-BTA-114604|reactome:R-BTA-193634|reactome:R-BTA-198203|reactome:R-BTA-392451|reactome:R-BTA-3928662|reactome:R-BTA-3928663|reactome:R-BTA-4086400|reactome:R-BTA-416482|reactome:R-BTA-5625900|reactome:R-BTA-5625970|reactome:R-BTA-5663220|reactome:R-BTA-5666185|reactome:R-BTA-5689896|reactome:R-BTA-6785631|reactome:R-BTA-6798695|reactome:R-BTA-8849471|reactome:R-BTA-8980692|reactome:R-BTA-9013106|go:"GO:0043231"(intracellular membrane-bounded organelle)|refseq:NP_788818.1|mint:MINT-6826247(identity)|uniprotkb:P61585(P61585) go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006096"(glycolytic process)|go:"GO:0008865"(fructokinase activity)|go:"GO:0019318"(hexose metabolic process)|go:"GO:0005536"(glucose binding)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0004340"(glucokinase activity)|go:"GO:0005524"(ATP binding)|refseq:NP_001012686.1|interpro:IPR022672|interpro:IPR001312(Hexokinase)|interpro:IPR019807|interpro:IPR022673|interpro:IPR043129|mint:Q5W5U3|mint:MINT-6826241(identity)|uniprotkb:Q5W5U3(Q5W5U3) - comment:mint|function:Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. May be an activator of PLCE1 comment:mint figure legend:T1|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins taxid:9913(bovine-spermatozoa)|taxid:9913(Bos taurus) - 2009/01/23 2014/10/16 rogid:Yd/tf5PgQoPCemLU4XUUyy0qVAE9913 rogid:DS4i1q1n5uioQX3uyan9glTz60c9913 intact-crc:415F33006D86E9E6|rigid:740KuCZebD1bWnnBxejiyqEwFLI false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0082"(peptide massfingerprinting) uniprotkb:P61585 uniprotkb:P79343 intact:EBI-7634751|ensembl:ENSBTAP00000005600|uniprotkb:Q3ZC72|intact:MINT-139651|uniprotkb:Q9UEJ4|uniprotkb:P06749 intact:EBI-7634680|intact:MINT-6825120 psi-mi:rhoa_bovin(display_long)|uniprotkb:RHOA(gene name)|psi-mi:RHOA(display_short)|uniprotkb:ARHA(gene name synonym)|uniprotkb:RHO12(gene name synonym)|uniprotkb:Gb(gene name synonym)|uniprotkb:p21(gene name synonym) psi-mi:p79343_bovin(display_long)|uniprotkb:bovine proacrosine(gene name)|psi-mi:bovine proacrosine(display_short) psi-mi:"MI:0019"(coimmunoprecipitation) Fiedler et al. (2008) pubmed:17928627|mint:MINT-6826213|doi:10.1095/biolreprod.107.062943 taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)") taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)") psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-7634819|mint:MINT-6826222 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSBTAG00000004279(gene)|ensembl:ENSBTAT00000005600(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001998"(angiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure)|go:"GO:0002363"(alpha-beta T cell lineage commitment)|go:"GO:0003100"(regulation of systemic arterial blood pressure by endothelin)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007015"(actin filament organization)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010812"(negative regulation of cell-substrate adhesion)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0016477"(cell migration)|go:"GO:0017022"(myosin binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021795"(cerebral cortex cell migration)|go:"GO:0021861"(forebrain radial glial cell differentiation)|go:"GO:0030027"(lamellipodium)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030496"(midbody)|go:"GO:0030521"(androgen receptor signaling pathway)|go:"GO:0030865"(cortical cytoskeleton organization)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0033144"(negative regulation of intracellular steroid hormone receptor signaling pathway)|go:"GO:0033688"(regulation of osteoblast proliferation)|go:"GO:0034329"(cell junction assembly)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035385"(Roundabout signaling pathway)|go:"GO:0036089"(cleavage furrow formation)|go:"GO:0038027"(apolipoprotein A-I-mediated signaling pathway)|go:"GO:0042476"(odontogenesis)|go:"GO:0042995"(cell projection)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0043197"(dendritic spine)|go:"GO:0043296"(apical junction complex)|go:"GO:0043297"(apical junction assembly)|go:"GO:0043366"(beta selection)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0043931"(ossification involved in bone maturation)|go:"GO:0044319"(wound healing, spreading of cells)|go:"GO:0045198"(establishment of epithelial cell apical/basal polarity)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0046638"(positive regulation of alpha-beta T cell differentiation)|go:"GO:0050919"(negative chemotaxis)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0060193"(positive regulation of lipase activity)|go:"GO:0061383"(trabecula morphogenesis)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:0090324"(negative regulation of oxidative phosphorylation)|go:"GO:0097498"(endothelial tube lumen extension)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902766"(skeletal muscle satellite cell migration)|go:"GO:1903427"(negative regulation of reactive oxygen species biosynthetic process)|go:"GO:1903673"(mitotic cleavage furrow formation)|go:"GO:1904695"(positive regulation of vascular associated smooth muscle contraction)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000177"(regulation of neural precursor cell proliferation)|go:"GO:2000406"(positive regulation of T cell migration)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P61585|reactome:R-BTA-114604|reactome:R-BTA-193634|reactome:R-BTA-198203|reactome:R-BTA-392451|reactome:R-BTA-3928662|reactome:R-BTA-3928663|reactome:R-BTA-4086400|reactome:R-BTA-416482|reactome:R-BTA-5625900|reactome:R-BTA-5625970|reactome:R-BTA-5663220|reactome:R-BTA-5666185|reactome:R-BTA-5689896|reactome:R-BTA-6785631|reactome:R-BTA-6798695|reactome:R-BTA-8849471|reactome:R-BTA-8980692|reactome:R-BTA-9013106|go:"GO:0043231"(intracellular membrane-bounded organelle)|refseq:NP_788818.1|mint:MINT-6826247(identity)|uniprotkb:P61585(P61585) mint:P79343|interpro:IPR033116|go:"GO:0004040"(amidase activity)|go:"GO:0004252"(serine-type endopeptidase activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005537"(mannose binding)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0007338"(single fertilization)|go:"GO:0007340"(acrosome reaction)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0042806"(fucose binding)|go:"GO:0043159"(acrosomal matrix)|interpro:IPR001314(Peptidase S1A, chymotrypsin)|interpro:IPR001254(Peptidase S1 and S6, chymotrypsin/Hap)|interpro:IPR018114|interpro:IPR012267(Peptidase S1A, acrosin)|interpro:IPR009003(Peptidase, trypsin-like serine and cysteine)|interpro:IPR043504|mint:MINT-6826226(identity)|uniprotkb:P79343(P79343) - comment:mint|function:Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. May be an activator of PLCE1 comment:mint figure legend:T1|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins taxid:9913(bovine-spermatozoa)|taxid:9913(Bos taurus) - 2009/01/23 2014/10/16 rogid:Yd/tf5PgQoPCemLU4XUUyy0qVAE9913 rogid:m1RZH17mYxhZg83SRsI5zAY9ldk9913 intact-crc:415F33006D86E9E6|rigid:740KuCZebD1bWnnBxejiyqEwFLI false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0082"(peptide massfingerprinting) uniprotkb:P61585 uniprotkb:P81948 intact:EBI-7634751|ensembl:ENSBTAP00000005600|uniprotkb:Q3ZC72|intact:MINT-139651|uniprotkb:Q9UEJ4|uniprotkb:P06749 intact:EBI-6943159|ensembl:ENSBTAP00000065307|uniprotkb:Q17QT1|intact:MINT-3387904|uniprotkb:Q5E986 psi-mi:rhoa_bovin(display_long)|uniprotkb:RHOA(gene name)|psi-mi:RHOA(display_short)|uniprotkb:ARHA(gene name synonym)|uniprotkb:RHO12(gene name synonym)|uniprotkb:Gb(gene name synonym)|uniprotkb:p21(gene name synonym) psi-mi:tba4a_bovin(display_long)|uniprotkb:TUBA1(gene name synonym)|uniprotkb:TUBA4A(gene name)|psi-mi:TUBA4A(display_short)|uniprotkb:Tubulin alpha-1 chain(gene name synonym)|uniprotkb:Alpha-tubulin 1(gene name synonym) psi-mi:"MI:0019"(coimmunoprecipitation) Fiedler et al. (2008) pubmed:17928627|mint:MINT-6826213|doi:10.1095/biolreprod.107.062943 taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)") taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)") psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-7634819|mint:MINT-6826222 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSBTAG00000004279(gene)|ensembl:ENSBTAT00000005600(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001998"(angiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure)|go:"GO:0002363"(alpha-beta T cell lineage commitment)|go:"GO:0003100"(regulation of systemic arterial blood pressure by endothelin)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007015"(actin filament organization)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010812"(negative regulation of cell-substrate adhesion)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0016477"(cell migration)|go:"GO:0017022"(myosin binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021795"(cerebral cortex cell migration)|go:"GO:0021861"(forebrain radial glial cell differentiation)|go:"GO:0030027"(lamellipodium)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030496"(midbody)|go:"GO:0030521"(androgen receptor signaling pathway)|go:"GO:0030865"(cortical cytoskeleton organization)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0033144"(negative regulation of intracellular steroid hormone receptor signaling pathway)|go:"GO:0033688"(regulation of osteoblast proliferation)|go:"GO:0034329"(cell junction assembly)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035385"(Roundabout signaling pathway)|go:"GO:0036089"(cleavage furrow formation)|go:"GO:0038027"(apolipoprotein A-I-mediated signaling pathway)|go:"GO:0042476"(odontogenesis)|go:"GO:0042995"(cell projection)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0043197"(dendritic spine)|go:"GO:0043296"(apical junction complex)|go:"GO:0043297"(apical junction assembly)|go:"GO:0043366"(beta selection)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0043931"(ossification involved in bone maturation)|go:"GO:0044319"(wound healing, spreading of cells)|go:"GO:0045198"(establishment of epithelial cell apical/basal polarity)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0046638"(positive regulation of alpha-beta T cell differentiation)|go:"GO:0050919"(negative chemotaxis)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0060193"(positive regulation of lipase activity)|go:"GO:0061383"(trabecula morphogenesis)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:0090324"(negative regulation of oxidative phosphorylation)|go:"GO:0097498"(endothelial tube lumen extension)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902766"(skeletal muscle satellite cell migration)|go:"GO:1903427"(negative regulation of reactive oxygen species biosynthetic process)|go:"GO:1903673"(mitotic cleavage furrow formation)|go:"GO:1904695"(positive regulation of vascular associated smooth muscle contraction)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000177"(regulation of neural precursor cell proliferation)|go:"GO:2000406"(positive regulation of T cell migration)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P61585|reactome:R-BTA-114604|reactome:R-BTA-193634|reactome:R-BTA-198203|reactome:R-BTA-392451|reactome:R-BTA-3928662|reactome:R-BTA-3928663|reactome:R-BTA-4086400|reactome:R-BTA-416482|reactome:R-BTA-5625900|reactome:R-BTA-5625970|reactome:R-BTA-5663220|reactome:R-BTA-5666185|reactome:R-BTA-5689896|reactome:R-BTA-6785631|reactome:R-BTA-6798695|reactome:R-BTA-8849471|reactome:R-BTA-8980692|reactome:R-BTA-9013106|go:"GO:0043231"(intracellular membrane-bounded organelle)|refseq:NP_788818.1|mint:MINT-6826247(identity)|uniprotkb:P61585(P61585) ensembl:ENSBTAG00000030974(gene)|ensembl:ENSBTAT00000085322(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005874"(microtubule)|go:"GO:0019901"(protein kinase binding)|interpro:IPR000217(Tubulin)|interpro:IPR002452(Alpha tubulin)|interpro:IPR003008(Tubulin/FtsZ, GTPase)|interpro:IPR008280(Tubulin/FtsZ, C-terminal)|interpro:IPR017975|interpro:IPR018316|interpro:IPR023123|interpro:IPR036525|interpro:IPR037103|mint:P81948|refseq:NP_001071626.1|mint:MINT-6826223(identity)|uniprotkb:P81948(P81948) - comment:mint|function:Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. May be an activator of PLCE1 comment:mint|function:Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain figure legend:T1|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins taxid:9913(bovine-spermatozoa)|taxid:9913(Bos taurus) - 2009/01/23 2014/10/16 rogid:Yd/tf5PgQoPCemLU4XUUyy0qVAE9913 rogid:6Oj9O8u7E6cLUJ1eT6y5slbk7uQ9913 intact-crc:415F33006D86E9E6|rigid:740KuCZebD1bWnnBxejiyqEwFLI false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0082"(peptide massfingerprinting) uniprotkb:P61585 uniprotkb:Q6B856 intact:EBI-7634751|ensembl:ENSBTAP00000005600|uniprotkb:Q3ZC72|intact:MINT-139651|uniprotkb:Q9UEJ4|uniprotkb:P06749 intact:EBI-7634703|intact:MINT-6604256 psi-mi:rhoa_bovin(display_long)|uniprotkb:RHOA(gene name)|psi-mi:RHOA(display_short)|uniprotkb:ARHA(gene name synonym)|uniprotkb:RHO12(gene name synonym)|uniprotkb:Gb(gene name synonym)|uniprotkb:p21(gene name synonym) psi-mi:tbb2b_bovin(display_long)|uniprotkb:TUBB2B(gene name)|psi-mi:TUBB2B(display_short) psi-mi:"MI:0019"(coimmunoprecipitation) Fiedler et al. (2008) pubmed:17928627|mint:MINT-6826213|doi:10.1095/biolreprod.107.062943 taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)") taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)") psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-7634819|mint:MINT-6826222 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSBTAG00000004279(gene)|ensembl:ENSBTAT00000005600(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001998"(angiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure)|go:"GO:0002363"(alpha-beta T cell lineage commitment)|go:"GO:0003100"(regulation of systemic arterial blood pressure by endothelin)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007015"(actin filament organization)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010812"(negative regulation of cell-substrate adhesion)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0016477"(cell migration)|go:"GO:0017022"(myosin binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021795"(cerebral cortex cell migration)|go:"GO:0021861"(forebrain radial glial cell differentiation)|go:"GO:0030027"(lamellipodium)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030496"(midbody)|go:"GO:0030521"(androgen receptor signaling pathway)|go:"GO:0030865"(cortical cytoskeleton organization)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0033144"(negative regulation of intracellular steroid hormone receptor signaling pathway)|go:"GO:0033688"(regulation of osteoblast proliferation)|go:"GO:0034329"(cell junction assembly)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035385"(Roundabout signaling pathway)|go:"GO:0036089"(cleavage furrow formation)|go:"GO:0038027"(apolipoprotein A-I-mediated signaling pathway)|go:"GO:0042476"(odontogenesis)|go:"GO:0042995"(cell projection)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0043197"(dendritic spine)|go:"GO:0043296"(apical junction complex)|go:"GO:0043297"(apical junction assembly)|go:"GO:0043366"(beta selection)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0043931"(ossification involved in bone maturation)|go:"GO:0044319"(wound healing, spreading of cells)|go:"GO:0045198"(establishment of epithelial cell apical/basal polarity)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0046638"(positive regulation of alpha-beta T cell differentiation)|go:"GO:0050919"(negative chemotaxis)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0060193"(positive regulation of lipase activity)|go:"GO:0061383"(trabecula morphogenesis)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:0090324"(negative regulation of oxidative phosphorylation)|go:"GO:0097498"(endothelial tube lumen extension)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902766"(skeletal muscle satellite cell migration)|go:"GO:1903427"(negative regulation of reactive oxygen species biosynthetic process)|go:"GO:1903673"(mitotic cleavage furrow formation)|go:"GO:1904695"(positive regulation of vascular associated smooth muscle contraction)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000177"(regulation of neural precursor cell proliferation)|go:"GO:2000406"(positive regulation of T cell migration)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P61585|reactome:R-BTA-114604|reactome:R-BTA-193634|reactome:R-BTA-198203|reactome:R-BTA-392451|reactome:R-BTA-3928662|reactome:R-BTA-3928663|reactome:R-BTA-4086400|reactome:R-BTA-416482|reactome:R-BTA-5625900|reactome:R-BTA-5625970|reactome:R-BTA-5663220|reactome:R-BTA-5666185|reactome:R-BTA-5689896|reactome:R-BTA-6785631|reactome:R-BTA-6798695|reactome:R-BTA-8849471|reactome:R-BTA-8980692|reactome:R-BTA-9013106|go:"GO:0043231"(intracellular membrane-bounded organelle)|refseq:NP_788818.1|mint:MINT-6826247(identity)|uniprotkb:P61585(P61585) mint:Q6B856|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005874"(microtubule)|go:"GO:0007017"(microtubule-based process)|go:"GO:0007399"(nervous system development)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:1902669"(positive regulation of axon guidance)|interpro:IPR000217(Tubulin)|interpro:IPR002453(Beta tubulin)|interpro:IPR003008(Tubulin/FtsZ, GTPase)|interpro:IPR008280(Tubulin/FtsZ, C-terminal)|interpro:IPR013838(Beta tubulin, autoregulation binding site)|interpro:IPR017975|interpro:IPR018316|interpro:IPR023123|interpro:IPR036525|interpro:IPR037103|rcsb pdb:1SA0|rcsb pdb:1SA1|rcsb pdb:1TVK|rcsb pdb:1Z2B|rcsb pdb:2P4N|rcsb pdb:2WBE|rcsb pdb:2XRP|rcsb pdb:3DCO|rcsb pdb:3DU7|rcsb pdb:3E22|rcsb pdb:3IZ0|rcsb pdb:3J1T|rcsb pdb:3J1U|rcsb pdb:3J2U|rcsb pdb:4AQV|rcsb pdb:4AQW|rcsb pdb:4ATU|rcsb pdb:4ATX|rcsb pdb:4CK5|rcsb pdb:4CK6|rcsb pdb:4CK7|rcsb pdb:4I4T|rcsb pdb:4I50|rcsb pdb:4I55|rcsb pdb:4IHJ|rcsb pdb:4IIJ|rcsb pdb:4O2A|rcsb pdb:4O2B|rcsb pdb:4O4H|rcsb pdb:4O4I|rcsb pdb:4O4J|rcsb pdb:4O4L|rcsb pdb:4TUY|rcsb pdb:4TV8|rcsb pdb:4TV9|rcsb pdb:4UXO|rcsb pdb:4UXP|rcsb pdb:4UXR|rcsb pdb:4UXS|rcsb pdb:4UXT|rcsb pdb:4UXY|rcsb pdb:4UY0|rcsb pdb:4YJ2|rcsb pdb:4YJ3|rcsb pdb:5EIB|rcsb pdb:5EZY|rcsb pdb:5GON|rcsb pdb:5H74|rcsb pdb:5H7O|rcsb pdb:5HNW|rcsb pdb:5HNX|rcsb pdb:5HNY|rcsb pdb:5HNZ|rcsb pdb:5ITZ|rcsb pdb:5IYZ|rcsb pdb:5J2T|rcsb pdb:5J2U|rcsb pdb:5JH7|rcsb pdb:5JVD|rcsb pdb:5LA6|rcsb pdb:5LOV|rcsb pdb:5LP6|rcsb pdb:5LXS|rcsb pdb:5LXT|rcsb pdb:5LYJ|rcsb pdb:5M50|rcsb pdb:5M54|rcsb pdb:5M5C|rcsb pdb:5M5I|rcsb pdb:5M5L|rcsb pdb:5M5M|rcsb pdb:5M5N|rcsb pdb:5M5O|rcsb pdb:5M7G|rcsb pdb:5M8D|rcsb pdb:5M8G|rcsb pdb:5MF4|rcsb pdb:5ND2|rcsb pdb:5ND3|rcsb pdb:5ND4|rcsb pdb:5ND7|rcsb pdb:5NFZ|rcsb pdb:5NG1|rcsb pdb:5NJH|rcsb pdb:5NM5|rcsb pdb:5NQT|rcsb pdb:5NQU|rcsb pdb:5O7A|rcsb pdb:5OSK|rcsb pdb:5OV7|rcsb pdb:5S4L|rcsb pdb:5S4M|rcsb pdb:5S4N|rcsb pdb:5S4O|rcsb pdb:5S4P|rcsb pdb:5S4Q|rcsb pdb:5S4R|rcsb pdb:5S4S|rcsb pdb:5S4T|rcsb pdb:5S4U|rcsb pdb:5S4V|rcsb pdb:5M7E|rcsb pdb:5S4W|rcsb pdb:5S4X|rcsb pdb:5S4Y|rcsb pdb:5S4Z|rcsb pdb:5S50|rcsb pdb:5S51|rcsb pdb:5S52|rcsb pdb:5S53|rcsb pdb:5S54|rcsb pdb:5S55|rcsb pdb:5S56|rcsb pdb:5S57|rcsb pdb:5S58|rcsb pdb:5S59|rcsb pdb:5S5A|rcsb pdb:5S5B|rcsb pdb:5S5C|rcsb pdb:5S5D|rcsb pdb:5S5E|rcsb pdb:5S5F|rcsb pdb:5S5G|rcsb pdb:5S5H|rcsb pdb:5S5I|rcsb pdb:5S5J|rcsb pdb:5S5K|rcsb pdb:5S5L|rcsb pdb:5S5M|rcsb pdb:5S5N|rcsb pdb:5S5O|rcsb pdb:5S5P|rcsb pdb:5S5Q|rcsb pdb:5S5R|rcsb pdb:5S5S|rcsb pdb:5S5T|rcsb pdb:5S5U|rcsb pdb:5S5V|rcsb pdb:5S5W|rcsb pdb:5S5X|rcsb pdb:5S5Y|rcsb pdb:5S5Z|rcsb pdb:5S60|rcsb pdb:5S61|rcsb pdb:5S62|rcsb pdb:5S63|rcsb pdb:5S64|rcsb pdb:5S65|rcsb pdb:5S66|rcsb pdb:5S67|rcsb pdb:5XAF|rcsb pdb:5XAG|rcsb pdb:5XLT|rcsb pdb:5XLZ|rcsb pdb:5YZ3|rcsb pdb:5Z4P|rcsb pdb:5Z4U|rcsb pdb:5ZXH|rcsb pdb:6AGK|rcsb pdb:6BBN|rcsb pdb:6F7C|rcsb pdb:6EG5|rcsb pdb:6FII|rcsb pdb:6FJF|rcsb pdb:6FJM|rcsb pdb:6FKJ|rcsb pdb:6FKL|rcsb pdb:6GF3|rcsb pdb:6GJ4|rcsb pdb:6GZE|rcsb pdb:6HX8|rcsb pdb:6I5C|rcsb pdb:6JCJ|rcsb pdb:6K9V|rcsb pdb:6KNZ|rcsb pdb:6N47|rcsb pdb:6OJQ|rcsb pdb:6QQN|rcsb pdb:6QTN|rcsb pdb:6REV|rcsb pdb:6RF2|rcsb pdb:6RF8|rcsb pdb:6RFD|rcsb pdb:6S8K|rcsb pdb:6S9E|rcsb pdb:6SES|rcsb pdb:6WVL|rcsb pdb:6WVM|rcsb pdb:6WVR|rcsb pdb:6Y6D|rcsb pdb:6ZWB|rcsb pdb:6ZWC|rcsb pdb:7JFR|refseq:NP_001003900.1|dip:DIP-47524N|mint:MINT-6826235(identity)|uniprotkb:Q6B856(Q6B856) - comment:mint|function:Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. May be an activator of PLCE1 comment:mint|function:Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain figure legend:T1|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins taxid:9913(bovine-spermatozoa)|taxid:9913(Bos taurus) - 2009/01/23 2014/10/16 rogid:Yd/tf5PgQoPCemLU4XUUyy0qVAE9913 rogid:sluQMryNuOvp6xlV558+agiRwvE9913 intact-crc:415F33006D86E9E6|rigid:740KuCZebD1bWnnBxejiyqEwFLI false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0082"(peptide massfingerprinting) uniprotkb:P61585 uniprotkb:Q3ZBY4 intact:EBI-7634751|ensembl:ENSBTAP00000005600|uniprotkb:Q3ZC72|intact:MINT-139651|uniprotkb:Q9UEJ4|uniprotkb:P06749 intact:EBI-7634865|intact:UNK-5917106|uniprotkb:F2Z4H4|uniprotkb:A5D981 psi-mi:rhoa_bovin(display_long)|uniprotkb:RHOA(gene name)|psi-mi:RHOA(display_short)|uniprotkb:ARHA(gene name synonym)|uniprotkb:RHO12(gene name synonym)|uniprotkb:Gb(gene name synonym)|uniprotkb:p21(gene name synonym) psi-mi:q3zby4_bovin(display_long)|uniprotkb:ALDOC(gene name)|psi-mi:ALDOC(display_short) psi-mi:"MI:0019"(coimmunoprecipitation) Fiedler et al. (2008) pubmed:17928627|mint:MINT-6826213|doi:10.1095/biolreprod.107.062943 taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)") taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)") psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-7634819|mint:MINT-6826222 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSBTAG00000004279(gene)|ensembl:ENSBTAT00000005600(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001998"(angiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure)|go:"GO:0002363"(alpha-beta T cell lineage commitment)|go:"GO:0003100"(regulation of systemic arterial blood pressure by endothelin)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007015"(actin filament organization)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010812"(negative regulation of cell-substrate adhesion)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0016477"(cell migration)|go:"GO:0017022"(myosin binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021795"(cerebral cortex cell migration)|go:"GO:0021861"(forebrain radial glial cell differentiation)|go:"GO:0030027"(lamellipodium)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030496"(midbody)|go:"GO:0030521"(androgen receptor signaling pathway)|go:"GO:0030865"(cortical cytoskeleton organization)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0033144"(negative regulation of intracellular steroid hormone receptor signaling pathway)|go:"GO:0033688"(regulation of osteoblast proliferation)|go:"GO:0034329"(cell junction assembly)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035385"(Roundabout signaling pathway)|go:"GO:0036089"(cleavage furrow formation)|go:"GO:0038027"(apolipoprotein A-I-mediated signaling pathway)|go:"GO:0042476"(odontogenesis)|go:"GO:0042995"(cell projection)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0043197"(dendritic spine)|go:"GO:0043296"(apical junction complex)|go:"GO:0043297"(apical junction assembly)|go:"GO:0043366"(beta selection)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0043931"(ossification involved in bone maturation)|go:"GO:0044319"(wound healing, spreading of cells)|go:"GO:0045198"(establishment of epithelial cell apical/basal polarity)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0046638"(positive regulation of alpha-beta T cell differentiation)|go:"GO:0050919"(negative chemotaxis)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0060193"(positive regulation of lipase activity)|go:"GO:0061383"(trabecula morphogenesis)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:0090324"(negative regulation of oxidative phosphorylation)|go:"GO:0097498"(endothelial tube lumen extension)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902766"(skeletal muscle satellite cell migration)|go:"GO:1903427"(negative regulation of reactive oxygen species biosynthetic process)|go:"GO:1903673"(mitotic cleavage furrow formation)|go:"GO:1904695"(positive regulation of vascular associated smooth muscle contraction)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000177"(regulation of neural precursor cell proliferation)|go:"GO:2000406"(positive regulation of T cell migration)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P61585|reactome:R-BTA-114604|reactome:R-BTA-193634|reactome:R-BTA-198203|reactome:R-BTA-392451|reactome:R-BTA-3928662|reactome:R-BTA-3928663|reactome:R-BTA-4086400|reactome:R-BTA-416482|reactome:R-BTA-5625900|reactome:R-BTA-5625970|reactome:R-BTA-5663220|reactome:R-BTA-5666185|reactome:R-BTA-5689896|reactome:R-BTA-6785631|reactome:R-BTA-6798695|reactome:R-BTA-8849471|reactome:R-BTA-8980692|reactome:R-BTA-9013106|go:"GO:0043231"(intracellular membrane-bounded organelle)|refseq:NP_788818.1|mint:MINT-6826247(identity)|uniprotkb:P61585(P61585) interpro:IPR029768|go:"GO:0004332"(fructose-bisphosphate aldolase activity)|go:"GO:0006096"(glycolytic process)|mint:Q3ZBY4|refseq:XP_005220131.1|interpro:IPR000741(Fructose-bisphosphate aldolase, class-I)|interpro:IPR013785(Aldolase-type TIM barrel)|refseq:NP_001091453.1|mint:MINT-6826232(identity)|uniprotkb:Q3ZBY4(Q3ZBY4) - comment:mint|function:Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. May be an activator of PLCE1 comment:mint figure legend:T1|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins taxid:9913(bovine-spermatozoa)|taxid:9913(Bos taurus) - 2009/01/23 2014/10/16 rogid:Yd/tf5PgQoPCemLU4XUUyy0qVAE9913 rogid:HYLlbdzzabOKAehzReKMnwFynGE9913 intact-crc:415F33006D86E9E6|rigid:740KuCZebD1bWnnBxejiyqEwFLI false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0082"(peptide massfingerprinting) uniprotkb:P61585 uniprotkb:Q29438 intact:EBI-7634751|ensembl:ENSBTAP00000005600|uniprotkb:Q3ZC72|intact:MINT-139651|uniprotkb:Q9UEJ4|uniprotkb:P06749 intact:EBI-7634805|intact:MINT-6825142 psi-mi:rhoa_bovin(display_long)|uniprotkb:RHOA(gene name)|psi-mi:RHOA(display_short)|uniprotkb:ARHA(gene name synonym)|uniprotkb:RHO12(gene name synonym)|uniprotkb:Gb(gene name synonym)|uniprotkb:p21(gene name synonym) psi-mi:odfp1_bovin(display_long)|uniprotkb:ODF1(gene name)|psi-mi:ODF1(display_short)|uniprotkb:ODFP(gene name synonym) psi-mi:"MI:0019"(coimmunoprecipitation) Fiedler et al. (2008) pubmed:17928627|mint:MINT-6826213|doi:10.1095/biolreprod.107.062943 taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)") taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)") psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-7634819|mint:MINT-6826222 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSBTAG00000004279(gene)|ensembl:ENSBTAT00000005600(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001998"(angiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure)|go:"GO:0002363"(alpha-beta T cell lineage commitment)|go:"GO:0003100"(regulation of systemic arterial blood pressure by endothelin)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007015"(actin filament organization)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010812"(negative regulation of cell-substrate adhesion)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0016477"(cell migration)|go:"GO:0017022"(myosin binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021795"(cerebral cortex cell migration)|go:"GO:0021861"(forebrain radial glial cell differentiation)|go:"GO:0030027"(lamellipodium)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030496"(midbody)|go:"GO:0030521"(androgen receptor signaling pathway)|go:"GO:0030865"(cortical cytoskeleton organization)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0033144"(negative regulation of intracellular steroid hormone receptor signaling pathway)|go:"GO:0033688"(regulation of osteoblast proliferation)|go:"GO:0034329"(cell junction assembly)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035385"(Roundabout signaling pathway)|go:"GO:0036089"(cleavage furrow formation)|go:"GO:0038027"(apolipoprotein A-I-mediated signaling pathway)|go:"GO:0042476"(odontogenesis)|go:"GO:0042995"(cell projection)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0043197"(dendritic spine)|go:"GO:0043296"(apical junction complex)|go:"GO:0043297"(apical junction assembly)|go:"GO:0043366"(beta selection)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0043931"(ossification involved in bone maturation)|go:"GO:0044319"(wound healing, spreading of cells)|go:"GO:0045198"(establishment of epithelial cell apical/basal polarity)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0046638"(positive regulation of alpha-beta T cell differentiation)|go:"GO:0050919"(negative chemotaxis)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0060193"(positive regulation of lipase activity)|go:"GO:0061383"(trabecula morphogenesis)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:0090324"(negative regulation of oxidative phosphorylation)|go:"GO:0097498"(endothelial tube lumen extension)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902766"(skeletal muscle satellite cell migration)|go:"GO:1903427"(negative regulation of reactive oxygen species biosynthetic process)|go:"GO:1903673"(mitotic cleavage furrow formation)|go:"GO:1904695"(positive regulation of vascular associated smooth muscle contraction)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000177"(regulation of neural precursor cell proliferation)|go:"GO:2000406"(positive regulation of T cell migration)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P61585|reactome:R-BTA-114604|reactome:R-BTA-193634|reactome:R-BTA-198203|reactome:R-BTA-392451|reactome:R-BTA-3928662|reactome:R-BTA-3928663|reactome:R-BTA-4086400|reactome:R-BTA-416482|reactome:R-BTA-5625900|reactome:R-BTA-5625970|reactome:R-BTA-5663220|reactome:R-BTA-5666185|reactome:R-BTA-5689896|reactome:R-BTA-6785631|reactome:R-BTA-6798695|reactome:R-BTA-8849471|reactome:R-BTA-8980692|reactome:R-BTA-9013106|go:"GO:0043231"(intracellular membrane-bounded organelle)|refseq:NP_788818.1|mint:MINT-6826247(identity)|uniprotkb:P61585(P61585) interpro:IPR037389|mint:Q29438|go:"GO:0001520"(outer dense fiber)|go:"GO:0007283"(spermatogenesis)|go:"GO:0030154"(cell differentiation)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR002068(Heat shock protein Hsp20)|interpro:IPR037552|mint:MINT-6826229(identity)|uniprotkb:Q29438(Q29438) - comment:mint|function:Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. May be an activator of PLCE1 function:"Component of the outer dense fibers (ODF) of spermatozoa. ODF are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail and may help to maintain the passive elastic structures and elastic recoil of the sperm tail"|comment:mint figure legend:T1|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins taxid:9913(bovine-spermatozoa)|taxid:9913(Bos taurus) - 2009/01/23 2014/10/16 rogid:Yd/tf5PgQoPCemLU4XUUyy0qVAE9913 rogid:NWThDESVb0SxerygtnuUGqkT8IU9913 intact-crc:415F33006D86E9E6|rigid:740KuCZebD1bWnnBxejiyqEwFLI false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0082"(peptide massfingerprinting) uniprotkb:P61585 uniprotkb:P12820 intact:EBI-7634751|ensembl:ENSBTAP00000005600|uniprotkb:Q3ZC72|intact:MINT-139651|uniprotkb:Q9UEJ4|uniprotkb:P06749 intact:EBI-7634845|intact:UNK-6024844|uniprotkb:Q0GA41 psi-mi:rhoa_bovin(display_long)|uniprotkb:RHOA(gene name)|psi-mi:RHOA(display_short)|uniprotkb:ARHA(gene name synonym)|uniprotkb:RHO12(gene name synonym)|uniprotkb:Gb(gene name synonym)|uniprotkb:p21(gene name synonym) psi-mi:ace_bovin(display_long)|uniprotkb:ACE(gene name)|psi-mi:ACE(display_short)|uniprotkb:DCP1(gene name synonym)|uniprotkb:Dipeptidyl carboxypeptidase I(gene name synonym)|uniprotkb:Kininase II(gene name synonym) psi-mi:"MI:0019"(coimmunoprecipitation) Fiedler et al. (2008) pubmed:17928627|mint:MINT-6826213|doi:10.1095/biolreprod.107.062943 taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)") taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)") psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-7634819|mint:MINT-6826222 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSBTAG00000004279(gene)|ensembl:ENSBTAT00000005600(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001998"(angiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure)|go:"GO:0002363"(alpha-beta T cell lineage commitment)|go:"GO:0003100"(regulation of systemic arterial blood pressure by endothelin)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007015"(actin filament organization)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010812"(negative regulation of cell-substrate adhesion)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0016477"(cell migration)|go:"GO:0017022"(myosin binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021795"(cerebral cortex cell migration)|go:"GO:0021861"(forebrain radial glial cell differentiation)|go:"GO:0030027"(lamellipodium)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030496"(midbody)|go:"GO:0030521"(androgen receptor signaling pathway)|go:"GO:0030865"(cortical cytoskeleton organization)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0033144"(negative regulation of intracellular steroid hormone receptor signaling pathway)|go:"GO:0033688"(regulation of osteoblast proliferation)|go:"GO:0034329"(cell junction assembly)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035385"(Roundabout signaling pathway)|go:"GO:0036089"(cleavage furrow formation)|go:"GO:0038027"(apolipoprotein A-I-mediated signaling pathway)|go:"GO:0042476"(odontogenesis)|go:"GO:0042995"(cell projection)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0043197"(dendritic spine)|go:"GO:0043296"(apical junction complex)|go:"GO:0043297"(apical junction assembly)|go:"GO:0043366"(beta selection)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0043931"(ossification involved in bone maturation)|go:"GO:0044319"(wound healing, spreading of cells)|go:"GO:0045198"(establishment of epithelial cell apical/basal polarity)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0046638"(positive regulation of alpha-beta T cell differentiation)|go:"GO:0050919"(negative chemotaxis)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0060193"(positive regulation of lipase activity)|go:"GO:0061383"(trabecula morphogenesis)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:0090324"(negative regulation of oxidative phosphorylation)|go:"GO:0097498"(endothelial tube lumen extension)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902766"(skeletal muscle satellite cell migration)|go:"GO:1903427"(negative regulation of reactive oxygen species biosynthetic process)|go:"GO:1903673"(mitotic cleavage furrow formation)|go:"GO:1904695"(positive regulation of vascular associated smooth muscle contraction)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000177"(regulation of neural precursor cell proliferation)|go:"GO:2000406"(positive regulation of T cell migration)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P61585|reactome:R-BTA-114604|reactome:R-BTA-193634|reactome:R-BTA-198203|reactome:R-BTA-392451|reactome:R-BTA-3928662|reactome:R-BTA-3928663|reactome:R-BTA-4086400|reactome:R-BTA-416482|reactome:R-BTA-5625900|reactome:R-BTA-5625970|reactome:R-BTA-5663220|reactome:R-BTA-5666185|reactome:R-BTA-5689896|reactome:R-BTA-6785631|reactome:R-BTA-6798695|reactome:R-BTA-8849471|reactome:R-BTA-8980692|reactome:R-BTA-9013106|go:"GO:0043231"(intracellular membrane-bounded organelle)|refseq:NP_788818.1|mint:MINT-6826247(identity)|uniprotkb:P61585(P61585) mint:P12820|go:"GO:0003081"(regulation of systemic arterial blood pressure by renin-angiotensin)|go:"GO:0003084"(positive regulation of systemic arterial blood pressure)|go:"GO:0004180"(carboxypeptidase activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005886"(plasma membrane)|go:"GO:0008237"(metallopeptidase activity)|go:"GO:0008241"(peptidyl-dipeptidase activity)|interpro:IPR001548(Peptidase M2, peptidyl-dipeptidase A)|mint:MINT-6826238(identity)|uniprotkb:P12820(P12820) - comment:mint|function:Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. May be an activator of PLCE1 comment:"fragmentation type: fragment"|comment:mint|function:Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin figure legend:T1|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins taxid:9913(bovine-spermatozoa)|taxid:9913(Bos taurus) - 2009/01/23 2014/10/16 rogid:Yd/tf5PgQoPCemLU4XUUyy0qVAE9913 rogid:h+c1EKVWsZ/oP4Q8/X45xgOFTOI9913 intact-crc:415F33006D86E9E6|rigid:740KuCZebD1bWnnBxejiyqEwFLI false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0082"(peptide massfingerprinting) uniprotkb:P61585 uniprotkb:Q9XS94 intact:EBI-7634751|ensembl:ENSBTAP00000005600|uniprotkb:Q3ZC72|intact:MINT-139651|uniprotkb:Q9UEJ4|uniprotkb:P06749 intact:EBI-7634882|intact:MINT-6825166 psi-mi:rhoa_bovin(display_long)|uniprotkb:RHOA(gene name)|psi-mi:RHOA(display_short)|uniprotkb:ARHA(gene name synonym)|uniprotkb:RHO12(gene name synonym)|uniprotkb:Gb(gene name synonym)|uniprotkb:p21(gene name synonym) psi-mi:q9xs94_bovin(display_long) psi-mi:"MI:0019"(coimmunoprecipitation) Fiedler et al. (2008) pubmed:17928627|mint:MINT-6826213|doi:10.1095/biolreprod.107.062943 taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)") taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)") psi-mi:"MI:0914"(association) psi-mi:"MI:0471"(MINT) intact:EBI-7634819|mint:MINT-6826222 - psi-mi:"MI:1060"(spoke expansion) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSBTAG00000004279(gene)|ensembl:ENSBTAT00000005600(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0001998"(angiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure)|go:"GO:0002363"(alpha-beta T cell lineage commitment)|go:"GO:0003100"(regulation of systemic arterial blood pressure by endothelin)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007015"(actin filament organization)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010812"(negative regulation of cell-substrate adhesion)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0016477"(cell migration)|go:"GO:0017022"(myosin binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021795"(cerebral cortex cell migration)|go:"GO:0021861"(forebrain radial glial cell differentiation)|go:"GO:0030027"(lamellipodium)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030496"(midbody)|go:"GO:0030521"(androgen receptor signaling pathway)|go:"GO:0030865"(cortical cytoskeleton organization)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0033144"(negative regulation of intracellular steroid hormone receptor signaling pathway)|go:"GO:0033688"(regulation of osteoblast proliferation)|go:"GO:0034329"(cell junction assembly)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035385"(Roundabout signaling pathway)|go:"GO:0036089"(cleavage furrow formation)|go:"GO:0038027"(apolipoprotein A-I-mediated signaling pathway)|go:"GO:0042476"(odontogenesis)|go:"GO:0042995"(cell projection)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0043197"(dendritic spine)|go:"GO:0043296"(apical junction complex)|go:"GO:0043297"(apical junction assembly)|go:"GO:0043366"(beta selection)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0043931"(ossification involved in bone maturation)|go:"GO:0044319"(wound healing, spreading of cells)|go:"GO:0045198"(establishment of epithelial cell apical/basal polarity)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0046638"(positive regulation of alpha-beta T cell differentiation)|go:"GO:0050919"(negative chemotaxis)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0060193"(positive regulation of lipase activity)|go:"GO:0061383"(trabecula morphogenesis)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:0090324"(negative regulation of oxidative phosphorylation)|go:"GO:0097498"(endothelial tube lumen extension)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1902766"(skeletal muscle satellite cell migration)|go:"GO:1903427"(negative regulation of reactive oxygen species biosynthetic process)|go:"GO:1903673"(mitotic cleavage furrow formation)|go:"GO:1904695"(positive regulation of vascular associated smooth muscle contraction)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000177"(regulation of neural precursor cell proliferation)|go:"GO:2000406"(positive regulation of T cell migration)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P61585|reactome:R-BTA-114604|reactome:R-BTA-193634|reactome:R-BTA-198203|reactome:R-BTA-392451|reactome:R-BTA-3928662|reactome:R-BTA-3928663|reactome:R-BTA-4086400|reactome:R-BTA-416482|reactome:R-BTA-5625900|reactome:R-BTA-5625970|reactome:R-BTA-5663220|reactome:R-BTA-5666185|reactome:R-BTA-5689896|reactome:R-BTA-6785631|reactome:R-BTA-6798695|reactome:R-BTA-8849471|reactome:R-BTA-8980692|reactome:R-BTA-9013106|go:"GO:0043231"(intracellular membrane-bounded organelle)|refseq:NP_788818.1|mint:MINT-6826247(identity)|uniprotkb:P61585(P61585) mint:Q9XS94|interpro:IPR018459|refseq:NP_776660.1|interpro:IPR018292|interpro:IPR008382(A-kinase anchor 110 kDa)|interpro:IPR020799|mint:MINT-6826244(identity)|uniprotkb:Q9XS94(Q9XS94) - comment:mint|function:Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. May be an activator of PLCE1 comment:mint figure legend:T1|comment:homomint|comment:mint|dataset:Virus - Publications including interactions involving viral proteins taxid:9913(bovine-spermatozoa)|taxid:9913(Bos taurus) - 2009/01/23 2014/10/16 rogid:Yd/tf5PgQoPCemLU4XUUyy0qVAE9913 rogid:REmrjCckKiP+YoXlFxwudlz3qTM9913 intact-crc:415F33006D86E9E6|rigid:740KuCZebD1bWnnBxejiyqEwFLI false - - - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0082"(peptide massfingerprinting) uniprotkb:P00515 uniprotkb:O77797 intact:EBI-7634955|ensembl:ENSBTAP00000018886|intact:MINT-1772188 intact:EBI-7634986|intact:MINT-6825173|uniprotkb:A6QQY3 psi-mi:kap2_bovin(display_long)|uniprotkb:PRKAR2A(gene name)|psi-mi:PRKAR2A(display_short) psi-mi:akap3_bovin(display_long)|uniprotkb:AKAP3(gene name)|psi-mi:AKAP3(display_short)|uniprotkb:AKAP110(gene name synonym)|uniprotkb:Protein kinase A-anchoring protein 3(gene name synonym)|uniprotkb:A-kinase anchor protein 110 kDa(gene name synonym) psi-mi:"MI:0049"(filter binding) Fiedler et al. (2008) pubmed:17928627|mint:MINT-6826213|doi:10.1095/biolreprod.107.062943 taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)") taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)") psi-mi:"MI:0915"(physical association) psi-mi:"MI:0471"(MINT) intact:EBI-7634981|mint:MINT-6826252 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSBTAG00000014205(gene)|ensembl:ENSBTAT00000018886(transcript)|go:"GO:0004862"(cAMP-dependent protein kinase inhibitor activity)|go:"GO:0005813"(centrosome)|go:"GO:0005930"(axoneme)|go:"GO:0005952"(cAMP-dependent protein kinase complex)|go:"GO:0008603"(cAMP-dependent protein kinase regulator activity)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030552"(cAMP binding)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0043949"(regulation of cAMP-mediated signaling)|go:"GO:0044853"(plasma membrane raft)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR003117(cAMP-dependent protein kinase, regulatory subunit, type I/II alpha/beta)|interpro:IPR012198(cAMP-dependent protein kinase regulatory subunit)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|interpro:IPR018490|mint:P00515|rcsb pdb:2APK|rcsb pdb:2BPK|refseq:NP_001178296.1|dip:DIP-546N|mint:MINT-6826253(identity)|uniprotkb:P00515(P00515) mint:O77797|go:"GO:0001669"(acrosomal vesicle)|refseq:NP_001094509.1|interpro:IPR018459|interpro:IPR018292|interpro:IPR008382(A-kinase anchor 110 kDa)|interpro:IPR020799|mint:MINT-6826256(identity)|uniprotkb:O77797(O77797) - comment:mint function:May function as a regulator of both motility- and head-associated functions such as capacitation and the acrosome reaction|comment:mint figure legend:F4|comment:mint|dataset:Virus - Publications including interactions involving viral proteins taxid:-1(in vitro)|taxid:-1(In vitro) - 2009/01/23 2014/10/16 rogid:HWS4DHvRjIRwtMNzivBNsoMsLTc9913 rogid:eo20cg6lWi8yaWAquZt/NtCjQug9913 intact-crc:3F1EDF8BEE49400F|rigid:F5UVPab7tNsHlgjuwLUQd+5oErw false - - - - psi-mi:"MI:0113"(western blot) psi-mi:"MI:0396"(predetermined participant) uniprotkb:O77797 uniprotkb:Q2T9N0 intact:EBI-7634986|intact:MINT-6825173|uniprotkb:A6QQY3 intact:EBI-7635114|intact:MINT-6825197 psi-mi:akap3_bovin(display_long)|uniprotkb:AKAP3(gene name)|psi-mi:AKAP3(display_short)|uniprotkb:AKAP110(gene name synonym)|uniprotkb:Protein kinase A-anchoring protein 3(gene name synonym)|uniprotkb:A-kinase anchor protein 110 kDa(gene name synonym) psi-mi:fscb_bovin(display_long)|uniprotkb:FSCB(gene name)|psi-mi:FSCB(display_short) psi-mi:"MI:0096"(pull down) Fiedler et al. (2008) pubmed:17928627|mint:MINT-6826213|doi:10.1095/biolreprod.107.062943 taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)") taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-7635109|mint:MINT-6826274 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0496"(bait) psi-mi:"MI:0498"(prey) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) mint:O77797|go:"GO:0001669"(acrosomal vesicle)|refseq:NP_001094509.1|interpro:IPR018459|interpro:IPR018292|interpro:IPR008382(A-kinase anchor 110 kDa)|interpro:IPR020799|mint:MINT-6826275(identity)|uniprotkb:O77797(O77797) go:"GO:0005509"(calcium ion binding)|go:"GO:0031514"(motile cilium)|go:"GO:0033234"(negative regulation of protein sumoylation)|mint:Q2T9N0|refseq:NP_001070014.1|interpro:IPR043375|mint:MINT-6826283(identity)|uniprotkb:Q2T9N0(Q2T9N0) - function:May function as a regulator of both motility- and head-associated functions such as capacitation and the acrosome reaction|comment:mint function:May be involved in the later stages of fibrous sheath biogenesis. Binds calcium|comment:mint figure legend:F3B F5|comment:mint|dataset:Virus - Publications including interactions involving viral proteins taxid:-1(in vitro)|taxid:-1(In vitro) - 2009/01/23 2014/10/16 rogid:eo20cg6lWi8yaWAquZt/NtCjQug9913 rogid:rWFXk48gS7lYjO4KNRUATddTNGY9913 intact-crc:2E46757619AD4815|rigid:k20JlbAV3Z56/MqkV/w7poxnnUA false tag:?-?(MINT-6826280)|binding-associated region:1-350(MINT-6826278) glutathione s tranferase tag:?-?(MINT-6826286) - - psi-mi:"MI:0396"(predetermined participant) psi-mi:"MI:0705"(anti tag western blot) uniprotkb:Q3T024 uniprotkb:O77797 intact:EBI-7635058|intact:MINT-6825187 intact:EBI-7634986|intact:MINT-6825173|uniprotkb:A6QQY3 psi-mi:rop1l_bovin(display_long)|uniprotkb:ROPN1L(gene name)|psi-mi:ROPN1L(display_short) psi-mi:akap3_bovin(display_long)|uniprotkb:AKAP3(gene name)|psi-mi:AKAP3(display_short)|uniprotkb:AKAP110(gene name synonym)|uniprotkb:Protein kinase A-anchoring protein 3(gene name synonym)|uniprotkb:A-kinase anchor protein 110 kDa(gene name synonym) psi-mi:"MI:0096"(pull down) Fiedler et al. (2008) pubmed:17928627|mint:MINT-6826213|doi:10.1095/biolreprod.107.062943 taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)") taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-7635069|mint:MINT-6826261 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) mint:Q3T024|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0005737"(cytoplasm)|go:"GO:0030317"(flagellated sperm motility)|go:"GO:0031514"(motile cilium)|go:"GO:0048240"(sperm capacitation)|refseq:NP_001069185.1|mint:MINT-6826269(identity)|uniprotkb:Q3T024(Q3T024) mint:O77797|go:"GO:0001669"(acrosomal vesicle)|refseq:NP_001094509.1|interpro:IPR018459|interpro:IPR018292|interpro:IPR008382(A-kinase anchor 110 kDa)|interpro:IPR020799|mint:MINT-6826262(identity)|uniprotkb:O77797(O77797) - comment:mint function:May function as a regulator of both motility- and head-associated functions such as capacitation and the acrosome reaction|comment:mint figure legend:F3A|comment:mint|dataset:Virus - Publications including interactions involving viral proteins taxid:-1(in vitro)|taxid:-1(In vitro) - 2009/01/23 2014/10/16 rogid:KB7aj7ij+tsAGl1+47ckMP/lQrE9913 rogid:eo20cg6lWi8yaWAquZt/NtCjQug9913 intact-crc:9D1F1A0DAAAF3B80|rigid:pWpjmbqgge00PF5dhDxoBhSHPfQ false glutathione s tranferase tag:?-?(MINT-6826272) tag:?-?(MINT-6826267)|binding-associated region:1-350(MINT-6826265) - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q3T064 uniprotkb:O77797 intact:EBI-7635160|intact:UNK-5913426 intact:EBI-7634986|intact:MINT-6825173|uniprotkb:A6QQY3 psi-mi:rop1_bovin(display_long)|uniprotkb:ROPN1(gene name)|psi-mi:ROPN1(display_short)|uniprotkb:Rhophilin-associated protein 1(gene name synonym) psi-mi:akap3_bovin(display_long)|uniprotkb:AKAP3(gene name)|psi-mi:AKAP3(display_short)|uniprotkb:AKAP110(gene name synonym)|uniprotkb:Protein kinase A-anchoring protein 3(gene name synonym)|uniprotkb:A-kinase anchor protein 110 kDa(gene name synonym) psi-mi:"MI:0096"(pull down) Fiedler et al. (2008) pubmed:17928627|mint:MINT-6826213|doi:10.1095/biolreprod.107.062943 taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)") taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-7635172|mint:MINT-6826288 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0005737"(cytoplasm)|go:"GO:0030317"(flagellated sperm motility)|go:"GO:0031514"(motile cilium)|go:"GO:0044782"(cilium organization)|go:"GO:0048240"(sperm capacitation)|go:"GO:0061512"(protein localization to cilium)|mint:Q3T064|refseq:NP_001069368.1|mint:MINT-6826296(identity)|uniprotkb:Q3T064(Q3T064) mint:O77797|go:"GO:0001669"(acrosomal vesicle)|refseq:NP_001094509.1|interpro:IPR018459|interpro:IPR018292|interpro:IPR008382(A-kinase anchor 110 kDa)|interpro:IPR020799|mint:MINT-6826289(identity)|uniprotkb:O77797(O77797) - comment:mint function:May function as a regulator of both motility- and head-associated functions such as capacitation and the acrosome reaction|comment:mint figure legend:F3C|comment:mint|dataset:Virus - Publications including interactions involving viral proteins taxid:-1(in vitro)|taxid:-1(In vitro) - 2009/01/23 2014/10/16 rogid:U5zZH9GjLdoKcWdPTjPCOX39pMc9913 rogid:eo20cg6lWi8yaWAquZt/NtCjQug9913 intact-crc:524F11FDE7C7AA04|rigid:BME/rScY94RvJMJFzNCpcScpuhI false glutathione s tranferase tag:?-?(MINT-6826299) tag:?-?(MINT-6826294)|binding-associated region:1-350(MINT-6826292) - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0396"(predetermined participant) uniprotkb:Q3SYS3 uniprotkb:O77797 intact:EBI-7635198|intact:MINT-6825208 intact:EBI-7634986|intact:MINT-6825173|uniprotkb:A6QQY3 psi-mi:q3sys3_bovin(display_long)|uniprotkb:SPA17(gene name)|psi-mi:SPA17(display_short)|uniprotkb:Sperm surface protein Sp17(gene name synonym) psi-mi:akap3_bovin(display_long)|uniprotkb:AKAP3(gene name)|psi-mi:AKAP3(display_short)|uniprotkb:AKAP110(gene name synonym)|uniprotkb:Protein kinase A-anchoring protein 3(gene name synonym)|uniprotkb:A-kinase anchor protein 110 kDa(gene name synonym) psi-mi:"MI:0096"(pull down) Fiedler et al. (2008) pubmed:17928627|mint:MINT-6826213|doi:10.1095/biolreprod.107.062943 taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)") taxid:9913(bovin)|taxid:9913("Bos taurus (Bovine)") psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-7635194|mint:MINT-6826301 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0498"(prey) psi-mi:"MI:0496"(bait) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0016020"(membrane)|mint:Q3SYS3|interpro:IPR012105(Sperm surface protein Sp17)|interpro:IPR000048(IQ calmodulin-binding region)|refseq:NP_001069908.1|interpro:IPR003117(cAMP-dependent protein kinase, regulatory subunit, type I/II alpha/beta)|mint:MINT-6826302(identity)|uniprotkb:Q3SYS3(Q3SYS3) mint:O77797|go:"GO:0001669"(acrosomal vesicle)|refseq:NP_001094509.1|interpro:IPR018459|interpro:IPR018292|interpro:IPR008382(A-kinase anchor 110 kDa)|interpro:IPR020799|mint:MINT-6826307(identity)|uniprotkb:O77797(O77797) - comment:mint function:May function as a regulator of both motility- and head-associated functions such as capacitation and the acrosome reaction|comment:mint figure legend:F3D|comment:mint|dataset:Virus - Publications including interactions involving viral proteins taxid:-1(in vitro)|taxid:-1(In vitro) - 2009/01/23 2014/10/16 rogid:WBi1BZTkJUbksGS5wGQlU5o/Qgk9913 rogid:eo20cg6lWi8yaWAquZt/NtCjQug9913 intact-crc:188DC2C6D3FD6B04|rigid:s/tbTiKASlsG+0gdSFCi41BrzLU false glutathione s tranferase tag:?-?(MINT-6826305) tag:?-?(MINT-6826312)|binding-associated region:1-350(MINT-6826310) - - psi-mi:"MI:0705"(anti tag western blot) psi-mi:"MI:0396"(predetermined participant)