#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P87379	uniprotkb:A5LHG3	intact:EBI-7610718|intact:MINT-7303561|uniprotkb:Q9PU11|uniprotkb:Q6GME6	intact:EBI-7610740|intact:MINT-7303533	psi-mi:grb2a_xenla(display_long)|uniprotkb:Adapter protein GRB2-A(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2-A(gene name synonym)|uniprotkb:grb2-a(gene name)|psi-mi:grb2-a(display_short)	psi-mi:a5lhg3_xenla(display_long)|uniprotkb:XPLCG1a(gene name)|psi-mi:XPLCG1a(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Browaeys-Poly et al. (2007)	pubmed:17869481|mint:MINT-7216093|doi:10.1016/j.cellsig.2007.08.002	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7610712|mint:MINT-7303590	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	mint:P87379|refseq:XP_018089703.1|refseq:XP_018089704.1|interpro:IPR001452(Src homology-3)|refseq:NP_001084357.1|interpro:IPR000980(SH2 motif)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0007143"(female meiotic nuclear division)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0043560"(insulin receptor substrate binding)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:MINT-7303593(identity)	interpro:IPR028380|mint:A5LHG3|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR018247|interpro:IPR001452(Src homology-3)|interpro:IPR011992(EF-Hand type)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR017946|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001711(Phospholipase C, phosphatidylinositol-specific, Y domain)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR016279(Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma)|interpro:IPR000909(Phospholipase C, phosphatidylinositol-specific , X region)|interpro:IPR001192("Phospholipase C, phosphoinositol-specific, C-terminal (PLC)")|interpro:IPR000980(SH2 motif)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0009395"(phospholipid catabolic process)|go:"GO:0035556"(intracellular signal transduction)|interpro:IPR035023|interpro:IPR035024|interpro:IPR035724|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|mint:MINT-7303592(identity)	-	comment:mint	comment:mint	comment:mint|comment:we have inferred SOS1 accession number to the human accession number although the protein has been detected in xenopus laevis cells.|figure legend:f5 f6|partial coverage:partial coverage|curation depth:mimix curation	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	-	2009/11/23	2014/10/16	rogid:S3V0tJ/t3X4GIQUOvsvve429aWo8355	rogid:9IYMTESk0oFajIUrPngTjjgOfkY8355	intact-crc:0527507B550FE9F0|rigid:P0y86yPZWBpEwsjda4ahgsa7Gkg	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P87379	uniprotkb:Q07889	intact:EBI-7610718|intact:MINT-7303561|uniprotkb:Q9PU11|uniprotkb:Q6GME6	intact:EBI-297487|intact:EBI-28968641|uniprotkb:A8K2G3|ensembl:ENSP00000384675|uniprotkb:B4DXG2	psi-mi:grb2a_xenla(display_long)|uniprotkb:Adapter protein GRB2-A(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2-A(gene name synonym)|uniprotkb:grb2-a(gene name)|psi-mi:grb2-a(display_short)	psi-mi:sos1_human(display_long)|uniprotkb:SOS1(gene name)|psi-mi:SOS1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Browaeys-Poly et al. (2007)	pubmed:17869481|mint:MINT-7216093|doi:10.1016/j.cellsig.2007.08.002	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7610712|mint:MINT-7303590	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	mint:P87379|refseq:XP_018089703.1|refseq:XP_018089704.1|interpro:IPR001452(Src homology-3)|refseq:NP_001084357.1|interpro:IPR000980(SH2 motif)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0007143"(female meiotic nuclear division)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0043560"(insulin receptor substrate binding)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:MINT-7303593(identity)	refseq:NP_005624.2|ensembl:ENSP00000384675|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5673001|reactome:R-HSA-74749|reactome:R-HSA-74751|reactome:R-HSA-8851805|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-8983432|reactome:R-HSA-9013149|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9028731|reactome:R-HSA-9034864|reactome:R-HSA-912526|reactome:R-HSA-9607240|reactome:R-HSA-9634285|reactome:R-HSA-9664565|reactome:R-HSA-9665348|ensembl:ENSG00000115904(gene)|ensembl:ENST00000402219(transcript)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001942"(hair follicle development)|go:"GO:0003209"(cardiac atrium morphogenesis)|go:"GO:0003344"(pericardium morphogenesis)|go:"GO:0003677"(DNA binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007296"(vitellogenesis)|go:"GO:0007411"(axon guidance)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0033081"(regulation of T cell differentiation in thymus)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0042129"(regulation of T cell proliferation)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0050900"(leukocyte migration)|go:"GO:0051057"(positive regulation of small GTPase mediated signal transduction)|go:"GO:0060021"(roof of mouth development)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0061384"(heart trabecula morphogenesis)|go:"GO:1904693"(midbrain morphogenesis)|go:"GO:2000973"(regulation of pro-B cell differentiation)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000651(Guanine nucleotide exchange factor for Ras-like GTPases, N-terminal)|interpro:IPR001849(Pleckstrin-like)|go:"GO:0005737"(cytoplasm)|interpro:IPR001895(Guanine-nucleotide dissociation stimulator CDC25)|interpro:IPR007125(Histone core)|interpro:IPR008937(Ras guanine nucleotide exchange factor)|interpro:IPR009072(Histone-fold)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR019804|interpro:IPR023578|interpro:IPR035899|interpro:IPR036964|mint:Q07889|rcsb pdb:1AWE|rcsb pdb:1BKD|rcsb pdb:1DBH|rcsb pdb:1NVU|rcsb pdb:1NVV|rcsb pdb:1NVW|rcsb pdb:1NVX|rcsb pdb:1Q9C|rcsb pdb:1XD2|rcsb pdb:1XD4|rcsb pdb:1XDV|rcsb pdb:2II0|rcsb pdb:3KSY|rcsb pdb:4NYI|rcsb pdb:4NYJ|rcsb pdb:4NYM|rcsb pdb:4URU|rcsb pdb:4URV|rcsb pdb:4URW|rcsb pdb:4URX|rcsb pdb:4URY|rcsb pdb:4URZ|rcsb pdb:4US0|rcsb pdb:4US1|rcsb pdb:4US2|rcsb pdb:5OVD|rcsb pdb:5OVE|rcsb pdb:5OVF|rcsb pdb:5OVG|rcsb pdb:5OVH|rcsb pdb:5OVI|rcsb pdb:5WFO|rcsb pdb:5WFP|rcsb pdb:5WFQ|rcsb pdb:5WFR|rcsb pdb:6BVI|rcsb pdb:6BVJ|rcsb pdb:6BVK|rcsb pdb:6BVL|rcsb pdb:6BVM|rcsb pdb:6CUO|rcsb pdb:6CUP|rcsb pdb:6CUR|rcsb pdb:6D55|rcsb pdb:6D56|rcsb pdb:6D59|rcsb pdb:6D5E|rcsb pdb:6D5G|rcsb pdb:6D5H|rcsb pdb:6D5J|rcsb pdb:6D5L|rcsb pdb:6D5M|rcsb pdb:6D5V|rcsb pdb:6D5W|rcsb pdb:6EPL|rcsb pdb:6EPM|rcsb pdb:6EPN|rcsb pdb:6EPO|rcsb pdb:6EPP|rcsb pdb:6F08|rcsb pdb:6SCM|rcsb pdb:6SFR|rcsb pdb:6V94|rcsb pdb:6V9F|rcsb pdb:6V9J|rcsb pdb:6V9L|rcsb pdb:6V9M|rcsb pdb:6V9N|rcsb pdb:6V9O|rcsb pdb:6Y44|rcsb pdb:7AVI|rcsb pdb:7AVL|rcsb pdb:7AVS|rcsb pdb:7AVT|rcsb pdb:7AVU|reactome:R-HSA-9665686|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9703465|reactome:R-HSA-9703648|reactome:R-HSA-983695|rcsb pdb:7AVV|rcsb pdb:7KFZ|reactome:R-HSA-112412|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-167044|reactome:R-HSA-179812|reactome:R-HSA-180336|reactome:R-HSA-186763|reactome:R-HSA-193648|reactome:R-HSA-1963640|reactome:R-HSA-210993|reactome:R-HSA-2179392|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-354194|reactome:R-HSA-375165|reactome:R-HSA-416482|reactome:R-HSA-428540|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654693|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5655253|dip:DIP-31802N|mint:MINT-7303594(identity)	-	comment:mint	-	comment:mint|comment:we have inferred SOS1 accession number to the human accession number although the protein has been detected in xenopus laevis cells.|figure legend:f5 f6|partial coverage:partial coverage|curation depth:mimix curation	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	-	2009/11/23	2014/10/16	rogid:S3V0tJ/t3X4GIQUOvsvve429aWo8355	rogid:SPXIrLMDF+XVcqKxBFgWsRGCFw89606	intact-crc:0527507B550FE9F0|rigid:P0y86yPZWBpEwsjda4ahgsa7Gkg	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P87379	uniprotkb:A5LHG3	intact:EBI-7610718|intact:MINT-7303561|uniprotkb:Q9PU11|uniprotkb:Q6GME6	intact:EBI-7610740|intact:MINT-7303533	psi-mi:grb2a_xenla(display_long)|uniprotkb:Adapter protein GRB2-A(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2-A(gene name synonym)|uniprotkb:grb2-a(gene name)|psi-mi:grb2-a(display_short)	psi-mi:a5lhg3_xenla(display_long)|uniprotkb:XPLCG1a(gene name)|psi-mi:XPLCG1a(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Browaeys-Poly et al. (2007)	pubmed:17869481|mint:MINT-7216093|doi:10.1016/j.cellsig.2007.08.002	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7610796|mint:MINT-7303607	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	mint:P87379|refseq:XP_018089703.1|refseq:XP_018089704.1|interpro:IPR001452(Src homology-3)|refseq:NP_001084357.1|interpro:IPR000980(SH2 motif)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0007143"(female meiotic nuclear division)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0043560"(insulin receptor substrate binding)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:MINT-7303611(identity)	interpro:IPR028380|mint:A5LHG3|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR018247|interpro:IPR001452(Src homology-3)|interpro:IPR011992(EF-Hand type)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR017946|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001711(Phospholipase C, phosphatidylinositol-specific, Y domain)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR016279(Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma)|interpro:IPR000909(Phospholipase C, phosphatidylinositol-specific , X region)|interpro:IPR001192("Phospholipase C, phosphoinositol-specific, C-terminal (PLC)")|interpro:IPR000980(SH2 motif)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0009395"(phospholipid catabolic process)|go:"GO:0035556"(intracellular signal transduction)|interpro:IPR035023|interpro:IPR035024|interpro:IPR035724|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|mint:MINT-7303613(identity)	-	comment:mint	comment:mint	comment:domino|comment:mint|comment:we have inferred SOS1 accession number to the human accession number although the protein has been detected in xenopus laevis cells.|figure legend:f7 f8|partial coverage:partial coverage|curation depth:mimix curation	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	-	2009/11/23	2014/10/16	rogid:S3V0tJ/t3X4GIQUOvsvve429aWo8355	rogid:9IYMTESk0oFajIUrPngTjjgOfkY8355	intact-crc:B6B2EB084ACB8142|rigid:P0y86yPZWBpEwsjda4ahgsa7Gkg	false	binding-associated region:168-227(MINT-7303622)	binding-associated region:?-?(MINT-7303618)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P87379	uniprotkb:Q07889	intact:EBI-7610718|intact:MINT-7303561|uniprotkb:Q9PU11|uniprotkb:Q6GME6	intact:EBI-297487|intact:EBI-28968641|uniprotkb:A8K2G3|ensembl:ENSP00000384675|uniprotkb:B4DXG2	psi-mi:grb2a_xenla(display_long)|uniprotkb:Adapter protein GRB2-A(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2-A(gene name synonym)|uniprotkb:grb2-a(gene name)|psi-mi:grb2-a(display_short)	psi-mi:sos1_human(display_long)|uniprotkb:SOS1(gene name)|psi-mi:SOS1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Browaeys-Poly et al. (2007)	pubmed:17869481|mint:MINT-7216093|doi:10.1016/j.cellsig.2007.08.002	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7610796|mint:MINT-7303607	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	mint:P87379|refseq:XP_018089703.1|refseq:XP_018089704.1|interpro:IPR001452(Src homology-3)|refseq:NP_001084357.1|interpro:IPR000980(SH2 motif)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0007143"(female meiotic nuclear division)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0043560"(insulin receptor substrate binding)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:MINT-7303611(identity)	refseq:NP_005624.2|ensembl:ENSP00000384675|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5673001|reactome:R-HSA-74749|reactome:R-HSA-74751|reactome:R-HSA-8851805|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-8983432|reactome:R-HSA-9013149|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9028731|reactome:R-HSA-9034864|reactome:R-HSA-912526|reactome:R-HSA-9607240|reactome:R-HSA-9634285|reactome:R-HSA-9664565|reactome:R-HSA-9665348|ensembl:ENSG00000115904(gene)|ensembl:ENST00000402219(transcript)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001942"(hair follicle development)|go:"GO:0003209"(cardiac atrium morphogenesis)|go:"GO:0003344"(pericardium morphogenesis)|go:"GO:0003677"(DNA binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007296"(vitellogenesis)|go:"GO:0007411"(axon guidance)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0033081"(regulation of T cell differentiation in thymus)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0042129"(regulation of T cell proliferation)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0050900"(leukocyte migration)|go:"GO:0051057"(positive regulation of small GTPase mediated signal transduction)|go:"GO:0060021"(roof of mouth development)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0061384"(heart trabecula morphogenesis)|go:"GO:1904693"(midbrain morphogenesis)|go:"GO:2000973"(regulation of pro-B cell differentiation)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000651(Guanine nucleotide exchange factor for Ras-like GTPases, N-terminal)|interpro:IPR001849(Pleckstrin-like)|go:"GO:0005737"(cytoplasm)|interpro:IPR001895(Guanine-nucleotide dissociation stimulator CDC25)|interpro:IPR007125(Histone core)|interpro:IPR008937(Ras guanine nucleotide exchange factor)|interpro:IPR009072(Histone-fold)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR019804|interpro:IPR023578|interpro:IPR035899|interpro:IPR036964|mint:Q07889|rcsb pdb:1AWE|rcsb pdb:1BKD|rcsb pdb:1DBH|rcsb pdb:1NVU|rcsb pdb:1NVV|rcsb pdb:1NVW|rcsb pdb:1NVX|rcsb pdb:1Q9C|rcsb pdb:1XD2|rcsb pdb:1XD4|rcsb pdb:1XDV|rcsb pdb:2II0|rcsb pdb:3KSY|rcsb pdb:4NYI|rcsb pdb:4NYJ|rcsb pdb:4NYM|rcsb pdb:4URU|rcsb pdb:4URV|rcsb pdb:4URW|rcsb pdb:4URX|rcsb pdb:4URY|rcsb pdb:4URZ|rcsb pdb:4US0|rcsb pdb:4US1|rcsb pdb:4US2|rcsb pdb:5OVD|rcsb pdb:5OVE|rcsb pdb:5OVF|rcsb pdb:5OVG|rcsb pdb:5OVH|rcsb pdb:5OVI|rcsb pdb:5WFO|rcsb pdb:5WFP|rcsb pdb:5WFQ|rcsb pdb:5WFR|rcsb pdb:6BVI|rcsb pdb:6BVJ|rcsb pdb:6BVK|rcsb pdb:6BVL|rcsb pdb:6BVM|rcsb pdb:6CUO|rcsb pdb:6CUP|rcsb pdb:6CUR|rcsb pdb:6D55|rcsb pdb:6D56|rcsb pdb:6D59|rcsb pdb:6D5E|rcsb pdb:6D5G|rcsb pdb:6D5H|rcsb pdb:6D5J|rcsb pdb:6D5L|rcsb pdb:6D5M|rcsb pdb:6D5V|rcsb pdb:6D5W|rcsb pdb:6EPL|rcsb pdb:6EPM|rcsb pdb:6EPN|rcsb pdb:6EPO|rcsb pdb:6EPP|rcsb pdb:6F08|rcsb pdb:6SCM|rcsb pdb:6SFR|rcsb pdb:6V94|rcsb pdb:6V9F|rcsb pdb:6V9J|rcsb pdb:6V9L|rcsb pdb:6V9M|rcsb pdb:6V9N|rcsb pdb:6V9O|rcsb pdb:6Y44|rcsb pdb:7AVI|rcsb pdb:7AVL|rcsb pdb:7AVS|rcsb pdb:7AVT|rcsb pdb:7AVU|reactome:R-HSA-9665686|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9703465|reactome:R-HSA-9703648|reactome:R-HSA-983695|rcsb pdb:7AVV|rcsb pdb:7KFZ|reactome:R-HSA-112412|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-167044|reactome:R-HSA-179812|reactome:R-HSA-180336|reactome:R-HSA-186763|reactome:R-HSA-193648|reactome:R-HSA-1963640|reactome:R-HSA-210993|reactome:R-HSA-2179392|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-354194|reactome:R-HSA-375165|reactome:R-HSA-416482|reactome:R-HSA-428540|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654693|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5655253|dip:DIP-31802N|mint:MINT-7303609(identity)	-	comment:mint	-	comment:domino|comment:mint|comment:we have inferred SOS1 accession number to the human accession number although the protein has been detected in xenopus laevis cells.|figure legend:f7 f8|partial coverage:partial coverage|curation depth:mimix curation	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	-	2009/11/23	2014/10/16	rogid:S3V0tJ/t3X4GIQUOvsvve429aWo8355	rogid:SPXIrLMDF+XVcqKxBFgWsRGCFw89606	intact-crc:B6B2EB084ACB8142|rigid:P0y86yPZWBpEwsjda4ahgsa7Gkg	false	binding-associated region:168-227(MINT-7303622)	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P87379	uniprotkb:A5LHG3	intact:EBI-7610718|intact:MINT-7303561|uniprotkb:Q9PU11|uniprotkb:Q6GME6	intact:EBI-7610740|intact:MINT-7303533	psi-mi:grb2a_xenla(display_long)|uniprotkb:Adapter protein GRB2-A(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2-A(gene name synonym)|uniprotkb:grb2-a(gene name)|psi-mi:grb2-a(display_short)	psi-mi:a5lhg3_xenla(display_long)|uniprotkb:XPLCG1a(gene name)|psi-mi:XPLCG1a(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Browaeys-Poly et al. (2007)	pubmed:17869481|mint:MINT-7216093|doi:10.1016/j.cellsig.2007.08.002	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7610840|mint:MINT-7303644	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	mint:P87379|refseq:XP_018089703.1|refseq:XP_018089704.1|interpro:IPR001452(Src homology-3)|refseq:NP_001084357.1|interpro:IPR000980(SH2 motif)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0007143"(female meiotic nuclear division)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0043560"(insulin receptor substrate binding)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:MINT-7303648(identity)	interpro:IPR028380|mint:A5LHG3|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR018247|interpro:IPR001452(Src homology-3)|interpro:IPR011992(EF-Hand type)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR017946|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001711(Phospholipase C, phosphatidylinositol-specific, Y domain)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR016279(Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma)|interpro:IPR000909(Phospholipase C, phosphatidylinositol-specific , X region)|interpro:IPR001192("Phospholipase C, phosphoinositol-specific, C-terminal (PLC)")|interpro:IPR000980(SH2 motif)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0009395"(phospholipid catabolic process)|go:"GO:0035556"(intracellular signal transduction)|interpro:IPR035023|interpro:IPR035024|interpro:IPR035724|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|mint:MINT-7303650(identity)	-	comment:mint	comment:mint	figure legend:f9|comment:domino|comment:mint|comment:we have inferred SOS1 accession number to the human accession number although the protein has been detected in xenopus laevis cells.|partial coverage:partial coverage|curation depth:mimix curation	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	-	2009/11/23	2014/10/16	rogid:S3V0tJ/t3X4GIQUOvsvve429aWo8355	rogid:9IYMTESk0oFajIUrPngTjjgOfkY8355	intact-crc:E4FCA976EE288D86|rigid:P0y86yPZWBpEwsjda4ahgsa7Gkg	false	-	binding-associated region:791-851(IPR000980)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P87379	uniprotkb:Q07889	intact:EBI-7610718|intact:MINT-7303561|uniprotkb:Q9PU11|uniprotkb:Q6GME6	intact:EBI-297487|intact:EBI-28968641|uniprotkb:A8K2G3|ensembl:ENSP00000384675|uniprotkb:B4DXG2	psi-mi:grb2a_xenla(display_long)|uniprotkb:Adapter protein GRB2-A(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2-A(gene name synonym)|uniprotkb:grb2-a(gene name)|psi-mi:grb2-a(display_short)	psi-mi:sos1_human(display_long)|uniprotkb:SOS1(gene name)|psi-mi:SOS1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Browaeys-Poly et al. (2007)	pubmed:17869481|mint:MINT-7216093|doi:10.1016/j.cellsig.2007.08.002	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7610840|mint:MINT-7303644	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	mint:P87379|refseq:XP_018089703.1|refseq:XP_018089704.1|interpro:IPR001452(Src homology-3)|refseq:NP_001084357.1|interpro:IPR000980(SH2 motif)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0007143"(female meiotic nuclear division)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0043560"(insulin receptor substrate binding)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:MINT-7303648(identity)	refseq:NP_005624.2|ensembl:ENSP00000384675|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5673001|reactome:R-HSA-74749|reactome:R-HSA-74751|reactome:R-HSA-8851805|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-8983432|reactome:R-HSA-9013149|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9028731|reactome:R-HSA-9034864|reactome:R-HSA-912526|reactome:R-HSA-9607240|reactome:R-HSA-9634285|reactome:R-HSA-9664565|reactome:R-HSA-9665348|ensembl:ENSG00000115904(gene)|ensembl:ENST00000402219(transcript)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001942"(hair follicle development)|go:"GO:0003209"(cardiac atrium morphogenesis)|go:"GO:0003344"(pericardium morphogenesis)|go:"GO:0003677"(DNA binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007296"(vitellogenesis)|go:"GO:0007411"(axon guidance)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0033081"(regulation of T cell differentiation in thymus)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0042129"(regulation of T cell proliferation)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0050900"(leukocyte migration)|go:"GO:0051057"(positive regulation of small GTPase mediated signal transduction)|go:"GO:0060021"(roof of mouth development)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0061384"(heart trabecula morphogenesis)|go:"GO:1904693"(midbrain morphogenesis)|go:"GO:2000973"(regulation of pro-B cell differentiation)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000651(Guanine nucleotide exchange factor for Ras-like GTPases, N-terminal)|interpro:IPR001849(Pleckstrin-like)|go:"GO:0005737"(cytoplasm)|interpro:IPR001895(Guanine-nucleotide dissociation stimulator CDC25)|interpro:IPR007125(Histone core)|interpro:IPR008937(Ras guanine nucleotide exchange factor)|interpro:IPR009072(Histone-fold)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR019804|interpro:IPR023578|interpro:IPR035899|interpro:IPR036964|mint:Q07889|rcsb pdb:1AWE|rcsb pdb:1BKD|rcsb pdb:1DBH|rcsb pdb:1NVU|rcsb pdb:1NVV|rcsb pdb:1NVW|rcsb pdb:1NVX|rcsb pdb:1Q9C|rcsb pdb:1XD2|rcsb pdb:1XD4|rcsb pdb:1XDV|rcsb pdb:2II0|rcsb pdb:3KSY|rcsb pdb:4NYI|rcsb pdb:4NYJ|rcsb pdb:4NYM|rcsb pdb:4URU|rcsb pdb:4URV|rcsb pdb:4URW|rcsb pdb:4URX|rcsb pdb:4URY|rcsb pdb:4URZ|rcsb pdb:4US0|rcsb pdb:4US1|rcsb pdb:4US2|rcsb pdb:5OVD|rcsb pdb:5OVE|rcsb pdb:5OVF|rcsb pdb:5OVG|rcsb pdb:5OVH|rcsb pdb:5OVI|rcsb pdb:5WFO|rcsb pdb:5WFP|rcsb pdb:5WFQ|rcsb pdb:5WFR|rcsb pdb:6BVI|rcsb pdb:6BVJ|rcsb pdb:6BVK|rcsb pdb:6BVL|rcsb pdb:6BVM|rcsb pdb:6CUO|rcsb pdb:6CUP|rcsb pdb:6CUR|rcsb pdb:6D55|rcsb pdb:6D56|rcsb pdb:6D59|rcsb pdb:6D5E|rcsb pdb:6D5G|rcsb pdb:6D5H|rcsb pdb:6D5J|rcsb pdb:6D5L|rcsb pdb:6D5M|rcsb pdb:6D5V|rcsb pdb:6D5W|rcsb pdb:6EPL|rcsb pdb:6EPM|rcsb pdb:6EPN|rcsb pdb:6EPO|rcsb pdb:6EPP|rcsb pdb:6F08|rcsb pdb:6SCM|rcsb pdb:6SFR|rcsb pdb:6V94|rcsb pdb:6V9F|rcsb pdb:6V9J|rcsb pdb:6V9L|rcsb pdb:6V9M|rcsb pdb:6V9N|rcsb pdb:6V9O|rcsb pdb:6Y44|rcsb pdb:7AVI|rcsb pdb:7AVL|rcsb pdb:7AVS|rcsb pdb:7AVT|rcsb pdb:7AVU|reactome:R-HSA-9665686|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9703465|reactome:R-HSA-9703648|reactome:R-HSA-983695|rcsb pdb:7AVV|rcsb pdb:7KFZ|reactome:R-HSA-112412|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-167044|reactome:R-HSA-179812|reactome:R-HSA-180336|reactome:R-HSA-186763|reactome:R-HSA-193648|reactome:R-HSA-1963640|reactome:R-HSA-210993|reactome:R-HSA-2179392|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-354194|reactome:R-HSA-375165|reactome:R-HSA-416482|reactome:R-HSA-428540|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654693|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5655253|dip:DIP-31802N|mint:MINT-7303646(identity)	-	comment:mint	-	figure legend:f9|comment:domino|comment:mint|comment:we have inferred SOS1 accession number to the human accession number although the protein has been detected in xenopus laevis cells.|partial coverage:partial coverage|curation depth:mimix curation	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	-	2009/11/23	2014/10/16	rogid:S3V0tJ/t3X4GIQUOvsvve429aWo8355	rogid:SPXIrLMDF+XVcqKxBFgWsRGCFw89606	intact-crc:E4FCA976EE288D86|rigid:P0y86yPZWBpEwsjda4ahgsa7Gkg	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P87379	uniprotkb:A5LHG3	intact:EBI-7610718|intact:MINT-7303561|uniprotkb:Q9PU11|uniprotkb:Q6GME6	intact:EBI-7610740|intact:MINT-7303533	psi-mi:grb2a_xenla(display_long)|uniprotkb:Adapter protein GRB2-A(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2-A(gene name synonym)|uniprotkb:grb2-a(gene name)|psi-mi:grb2-a(display_short)	psi-mi:a5lhg3_xenla(display_long)|uniprotkb:XPLCG1a(gene name)|psi-mi:XPLCG1a(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Browaeys-Poly et al. (2007)	pubmed:17869481|mint:MINT-7216093|doi:10.1016/j.cellsig.2007.08.002	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7610820|mint:MINT-7303626	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	mint:P87379|refseq:XP_018089703.1|refseq:XP_018089704.1|interpro:IPR001452(Src homology-3)|refseq:NP_001084357.1|interpro:IPR000980(SH2 motif)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0007143"(female meiotic nuclear division)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0043560"(insulin receptor substrate binding)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:MINT-7303633(identity)	interpro:IPR028380|mint:A5LHG3|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR018247|interpro:IPR001452(Src homology-3)|interpro:IPR011992(EF-Hand type)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR017946|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001711(Phospholipase C, phosphatidylinositol-specific, Y domain)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR016279(Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma)|interpro:IPR000909(Phospholipase C, phosphatidylinositol-specific , X region)|interpro:IPR001192("Phospholipase C, phosphoinositol-specific, C-terminal (PLC)")|interpro:IPR000980(SH2 motif)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0009395"(phospholipid catabolic process)|go:"GO:0035556"(intracellular signal transduction)|interpro:IPR035023|interpro:IPR035024|interpro:IPR035724|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|mint:MINT-7303628(identity)	-	comment:mint	comment:mint	figure legend:f9|comment:domino|comment:mint|comment:we have inferred SOS1 accession number to the human accession number although the protein has been detected in xenopus laevis cells.|partial coverage:partial coverage|curation depth:mimix curation	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	-	2009/11/23	2014/10/16	rogid:S3V0tJ/t3X4GIQUOvsvve429aWo8355	rogid:9IYMTESk0oFajIUrPngTjjgOfkY8355	intact-crc:A28718B2FC8E517E|rigid:P0y86yPZWBpEwsjda4ahgsa7Gkg	false	-	binding-associated region:550-756(MINT-7303629)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:P87379	uniprotkb:Q07889	intact:EBI-7610718|intact:MINT-7303561|uniprotkb:Q9PU11|uniprotkb:Q6GME6	intact:EBI-297487|intact:EBI-28968641|uniprotkb:A8K2G3|ensembl:ENSP00000384675|uniprotkb:B4DXG2	psi-mi:grb2a_xenla(display_long)|uniprotkb:Adapter protein GRB2-A(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2-A(gene name synonym)|uniprotkb:grb2-a(gene name)|psi-mi:grb2-a(display_short)	psi-mi:sos1_human(display_long)|uniprotkb:SOS1(gene name)|psi-mi:SOS1(display_short)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Browaeys-Poly et al. (2007)	pubmed:17869481|mint:MINT-7216093|doi:10.1016/j.cellsig.2007.08.002	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0914"(association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7610820|mint:MINT-7303626	-	psi-mi:"MI:1060"(spoke expansion)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	mint:P87379|refseq:XP_018089703.1|refseq:XP_018089704.1|interpro:IPR001452(Src homology-3)|refseq:NP_001084357.1|interpro:IPR000980(SH2 motif)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0007143"(female meiotic nuclear division)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0043560"(insulin receptor substrate binding)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:MINT-7303633(identity)	refseq:NP_005624.2|ensembl:ENSP00000384675|reactome:R-HSA-5655291|reactome:R-HSA-5655302|reactome:R-HSA-5673001|reactome:R-HSA-74749|reactome:R-HSA-74751|reactome:R-HSA-8851805|reactome:R-HSA-8853334|reactome:R-HSA-8853338|reactome:R-HSA-8853659|reactome:R-HSA-8983432|reactome:R-HSA-9013149|reactome:R-HSA-9026519|reactome:R-HSA-9027284|reactome:R-HSA-9028731|reactome:R-HSA-9034864|reactome:R-HSA-912526|reactome:R-HSA-9607240|reactome:R-HSA-9634285|reactome:R-HSA-9664565|reactome:R-HSA-9665348|ensembl:ENSG00000115904(gene)|ensembl:ENST00000402219(transcript)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001942"(hair follicle development)|go:"GO:0003209"(cardiac atrium morphogenesis)|go:"GO:0003344"(pericardium morphogenesis)|go:"GO:0003677"(DNA binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007296"(vitellogenesis)|go:"GO:0007411"(axon guidance)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0033081"(regulation of T cell differentiation in thymus)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0038095"(Fc-epsilon receptor signaling pathway)|go:"GO:0042129"(regulation of T cell proliferation)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0050900"(leukocyte migration)|go:"GO:0051057"(positive regulation of small GTPase mediated signal transduction)|go:"GO:0060021"(roof of mouth development)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0061384"(heart trabecula morphogenesis)|go:"GO:1904693"(midbrain morphogenesis)|go:"GO:2000973"(regulation of pro-B cell differentiation)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000651(Guanine nucleotide exchange factor for Ras-like GTPases, N-terminal)|interpro:IPR001849(Pleckstrin-like)|go:"GO:0005737"(cytoplasm)|interpro:IPR001895(Guanine-nucleotide dissociation stimulator CDC25)|interpro:IPR007125(Histone core)|interpro:IPR008937(Ras guanine nucleotide exchange factor)|interpro:IPR009072(Histone-fold)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR019804|interpro:IPR023578|interpro:IPR035899|interpro:IPR036964|mint:Q07889|rcsb pdb:1AWE|rcsb pdb:1BKD|rcsb pdb:1DBH|rcsb pdb:1NVU|rcsb pdb:1NVV|rcsb pdb:1NVW|rcsb pdb:1NVX|rcsb pdb:1Q9C|rcsb pdb:1XD2|rcsb pdb:1XD4|rcsb pdb:1XDV|rcsb pdb:2II0|rcsb pdb:3KSY|rcsb pdb:4NYI|rcsb pdb:4NYJ|rcsb pdb:4NYM|rcsb pdb:4URU|rcsb pdb:4URV|rcsb pdb:4URW|rcsb pdb:4URX|rcsb pdb:4URY|rcsb pdb:4URZ|rcsb pdb:4US0|rcsb pdb:4US1|rcsb pdb:4US2|rcsb pdb:5OVD|rcsb pdb:5OVE|rcsb pdb:5OVF|rcsb pdb:5OVG|rcsb pdb:5OVH|rcsb pdb:5OVI|rcsb pdb:5WFO|rcsb pdb:5WFP|rcsb pdb:5WFQ|rcsb pdb:5WFR|rcsb pdb:6BVI|rcsb pdb:6BVJ|rcsb pdb:6BVK|rcsb pdb:6BVL|rcsb pdb:6BVM|rcsb pdb:6CUO|rcsb pdb:6CUP|rcsb pdb:6CUR|rcsb pdb:6D55|rcsb pdb:6D56|rcsb pdb:6D59|rcsb pdb:6D5E|rcsb pdb:6D5G|rcsb pdb:6D5H|rcsb pdb:6D5J|rcsb pdb:6D5L|rcsb pdb:6D5M|rcsb pdb:6D5V|rcsb pdb:6D5W|rcsb pdb:6EPL|rcsb pdb:6EPM|rcsb pdb:6EPN|rcsb pdb:6EPO|rcsb pdb:6EPP|rcsb pdb:6F08|rcsb pdb:6SCM|rcsb pdb:6SFR|rcsb pdb:6V94|rcsb pdb:6V9F|rcsb pdb:6V9J|rcsb pdb:6V9L|rcsb pdb:6V9M|rcsb pdb:6V9N|rcsb pdb:6V9O|rcsb pdb:6Y44|rcsb pdb:7AVI|rcsb pdb:7AVL|rcsb pdb:7AVS|rcsb pdb:7AVT|rcsb pdb:7AVU|reactome:R-HSA-9665686|reactome:R-HSA-9670439|reactome:R-HSA-9673767|reactome:R-HSA-9673770|reactome:R-HSA-9703465|reactome:R-HSA-9703648|reactome:R-HSA-983695|rcsb pdb:7AVV|rcsb pdb:7KFZ|reactome:R-HSA-112412|reactome:R-HSA-1236382|reactome:R-HSA-1250196|reactome:R-HSA-1250347|reactome:R-HSA-1433557|reactome:R-HSA-1433559|reactome:R-HSA-167044|reactome:R-HSA-179812|reactome:R-HSA-180336|reactome:R-HSA-186763|reactome:R-HSA-193648|reactome:R-HSA-1963640|reactome:R-HSA-210993|reactome:R-HSA-2179392|reactome:R-HSA-2424491|reactome:R-HSA-2428933|reactome:R-HSA-2730905|reactome:R-HSA-2871796|reactome:R-HSA-2871809|reactome:R-HSA-354194|reactome:R-HSA-375165|reactome:R-HSA-416482|reactome:R-HSA-428540|reactome:R-HSA-5637810|reactome:R-HSA-5654688|reactome:R-HSA-5654693|reactome:R-HSA-5654699|reactome:R-HSA-5654700|reactome:R-HSA-5654704|reactome:R-HSA-5654706|reactome:R-HSA-5654712|reactome:R-HSA-5654719|reactome:R-HSA-5655253|dip:DIP-31802N|mint:MINT-7303638(identity)	-	comment:mint	-	figure legend:f9|comment:domino|comment:mint|comment:we have inferred SOS1 accession number to the human accession number although the protein has been detected in xenopus laevis cells.|partial coverage:partial coverage|curation depth:mimix curation	taxid:8355(xenla)|taxid:8355("Xenopus laevis (African clawed frog)")	-	2009/11/23	2014/10/16	rogid:S3V0tJ/t3X4GIQUOvsvve429aWo8355	rogid:SPXIrLMDF+XVcqKxBFgWsRGCFw89606	intact-crc:A28718B2FC8E517E|rigid:P0y86yPZWBpEwsjda4ahgsa7Gkg	false	-	-	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)