#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P05062	uniprotkb:P55014	intact:EBI-1045507|uniprotkb:Q5T7D6|uniprotkb:Q13741|uniprotkb:Q13742|ensembl:ENSP00000497731|ensembl:ENSP00000497767|ensembl:ENSP00000497990	intact:EBI-2506299|uniprotkb:O35938|uniprotkb:Q91W55|uniprotkb:Q9Z1E0	psi-mi:aldob_human(display_long)|uniprotkb:ALDOB(gene name)|psi-mi:ALDOB(display_short)|uniprotkb:ALDB(gene name synonym)|uniprotkb:Liver-type aldolase(gene name synonym)	psi-mi:s12a1_mouse(display_long)|uniprotkb:Slc12a1(gene name)|psi-mi:Slc12a1(display_short)|uniprotkb:Nkcc2(gene name synonym)|uniprotkb:"Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2"(gene name synonym)|uniprotkb:BSC1(gene name synonym)|uniprotkb:Kidney-specific Na-K-Cl symporter(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Benziane et al. (2007)	pubmed:17848580|imex:IM-20407	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2506351|imex:IM-20407-1	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000026.2|ensembl:ENST00000647789(transcript)|ensembl:ENST00000648064(transcript)|ensembl:ENST00000648758(transcript)|go:"GO:0004332"(fructose-bisphosphate aldolase activity)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0006000"(fructose metabolic process)|go:"GO:0006096"(glycolytic process)|go:"GO:0006116"(NADH oxidation)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0030388"(fructose 1,6-bisphosphate metabolic process)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0034451"(centriolar satellite)|go:"GO:0042802"(identical protein binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0061609"(fructose-1-phosphate aldolase activity)|go:"GO:0070061"(fructose binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070072"(vacuolar proton-transporting V-type ATPase complex assembly)|interpro:IPR000741(Fructose-bisphosphate aldolase, class-I)|interpro:IPR013785(Aldolase-type TIM barrel)|interpro:IPR029768|rcsb pdb:1QO5|rcsb pdb:1XDL|rcsb pdb:1XDM|reactome:R-HSA-5657560|reactome:R-HSA-70171|reactome:R-HSA-70263|reactome:R-HSA-70350|ensembl:ENSG00000136872(gene)	go:"GO:0006884"(cell volume homeostasis)|go:"GO:0007588"(excretion)|go:"GO:0008511"("sodium:potassium:chloride symporter activity")|go:"GO:0009986"(cell surface)|go:"GO:0015379"("potassium:chloride symporter activity")|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0032978"(protein insertion into membrane from inner side)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0048878"(chemical homeostasis)|go:"GO:0055064"(chloride ion homeostasis)|go:"GO:0055075"(potassium ion homeostasis)|go:"GO:0055078"(sodium ion homeostasis)|go:"GO:0070062"(extracellular exosome)|go:"GO:1902476"(chloride transmembrane transport)|go:"GO:1990573"(potassium ion import across plasma membrane)|reactome:R-MMU-426117|go:"GO:0001822"(kidney development)|go:"GO:0005886"(plasma membrane)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006814"(sodium ion transport)|go:"GO:0006821"(chloride transport)|refseq:NP_001073158.1|refseq:NP_899197.2|interpro:IPR004841(Amino acid permease-associated region)|interpro:IPR013612(Amino acid permease N-terminal)|interpro:IPR002443(Na-K-Cl co-transporter)|interpro:IPR002445(Na-K-Cl co-transporter 2)|interpro:IPR004842(Na-K-Cl cotransporter superfamily)|interpro:IPR018491|mint:P55014	-	-	-	figure legend:Fig. 3C.|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2009/12/03	2014/10/16	rogid:Bio5Ywd/bEDrDUsJ3DsO1IEhE3M9606	rogid:v2s/Y9bQ9vzadNOF1SLuw94Qylo10090	intact-crc:37F3D93AB6C0F796|rigid:ltFYpUTzpMObM3KMxxjoCXoWOOE	false	sufficient binding region:190-364(IPR000741)	sufficient binding region:661-768(IPR004842)	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P05062	uniprotkb:P55014	intact:EBI-1045507|uniprotkb:Q5T7D6|uniprotkb:Q13741|uniprotkb:Q13742|ensembl:ENSP00000497731|ensembl:ENSP00000497767|ensembl:ENSP00000497990	intact:EBI-2506299|uniprotkb:O35938|uniprotkb:Q91W55|uniprotkb:Q9Z1E0	psi-mi:aldob_human(display_long)|uniprotkb:ALDOB(gene name)|psi-mi:ALDOB(display_short)|uniprotkb:ALDB(gene name synonym)|uniprotkb:Liver-type aldolase(gene name synonym)	psi-mi:s12a1_mouse(display_long)|uniprotkb:Slc12a1(gene name)|psi-mi:Slc12a1(display_short)|uniprotkb:Nkcc2(gene name synonym)|uniprotkb:"Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2"(gene name synonym)|uniprotkb:BSC1(gene name synonym)|uniprotkb:Kidney-specific Na-K-Cl symporter(gene name synonym)	psi-mi:"MI:0663"(confocal microscopy)	Benziane et al. (2007)	pubmed:17848580|imex:IM-20407	taxid:9606(human)|taxid:9606(Homo sapiens)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0403"(colocalization)	psi-mi:"MI:0469"(IntAct)	intact:EBI-2506521|imex:IM-20407-2	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_000026.2|ensembl:ENST00000647789(transcript)|ensembl:ENST00000648064(transcript)|ensembl:ENST00000648758(transcript)|go:"GO:0004332"(fructose-bisphosphate aldolase activity)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0006000"(fructose metabolic process)|go:"GO:0006096"(glycolytic process)|go:"GO:0006116"(NADH oxidation)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0030388"(fructose 1,6-bisphosphate metabolic process)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0034451"(centriolar satellite)|go:"GO:0042802"(identical protein binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0061609"(fructose-1-phosphate aldolase activity)|go:"GO:0070061"(fructose binding)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070072"(vacuolar proton-transporting V-type ATPase complex assembly)|interpro:IPR000741(Fructose-bisphosphate aldolase, class-I)|interpro:IPR013785(Aldolase-type TIM barrel)|interpro:IPR029768|rcsb pdb:1QO5|rcsb pdb:1XDL|rcsb pdb:1XDM|reactome:R-HSA-5657560|reactome:R-HSA-70171|reactome:R-HSA-70263|reactome:R-HSA-70350|ensembl:ENSG00000136872(gene)	go:"GO:0006884"(cell volume homeostasis)|go:"GO:0007588"(excretion)|go:"GO:0008511"("sodium:potassium:chloride symporter activity")|go:"GO:0009986"(cell surface)|go:"GO:0015379"("potassium:chloride symporter activity")|go:"GO:0016021"(integral component of membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0032978"(protein insertion into membrane from inner side)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0035725"(sodium ion transmembrane transport)|go:"GO:0048878"(chemical homeostasis)|go:"GO:0055064"(chloride ion homeostasis)|go:"GO:0055075"(potassium ion homeostasis)|go:"GO:0055078"(sodium ion homeostasis)|go:"GO:0070062"(extracellular exosome)|go:"GO:1902476"(chloride transmembrane transport)|go:"GO:1990573"(potassium ion import across plasma membrane)|reactome:R-MMU-426117|go:"GO:0001822"(kidney development)|go:"GO:0005886"(plasma membrane)|go:"GO:0006813"(potassium ion transport)|go:"GO:0006814"(sodium ion transport)|go:"GO:0006821"(chloride transport)|refseq:NP_001073158.1|refseq:NP_899197.2|interpro:IPR004841(Amino acid permease-associated region)|interpro:IPR013612(Amino acid permease N-terminal)|interpro:IPR002443(Na-K-Cl co-transporter)|interpro:IPR002445(Na-K-Cl co-transporter 2)|interpro:IPR004842(Na-K-Cl cotransporter superfamily)|interpro:IPR018491|mint:P55014	-	-	-	figure legend:Fig. 7|full coverage:Only protein-protein interactions|curation depth:imex curation	taxid:10090(mouse-mktal)|taxid:10090(Mouse thick ascending limb cell line)	-	2009/12/03	2014/10/16	rogid:Bio5Ywd/bEDrDUsJ3DsO1IEhE3M9606	rogid:v2s/Y9bQ9vzadNOF1SLuw94Qylo10090	intact-crc:328E1E4ABF540DBD|rigid:ltFYpUTzpMObM3KMxxjoCXoWOOE	false	v5 tag:?-?	enhanced green fluorescent protein tag:?-?	-	-	psi-mi:"MI:0422"(immunostaining)	psi-mi:"MI:0422"(immunostaining)