#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:Q8K382	uniprotkb:Q62420	intact:EBI-7186684|ensembl:ENSMUSP00000099848|intact:UNK-5974119|uniprotkb:A0MCI0|uniprotkb:A2ALU2	intact:EBI-77971|ensembl:ENSMUSP00000030212|uniprotkb:Q3UTL7|uniprotkb:Q3UY49|uniprotkb:Q8BXS6|uniprotkb:Q8VBV1	psi-mi:den1a_mouse(display_long)|uniprotkb:Connecdenn 1(gene name synonym)|uniprotkb:Dennd1a(gene name)|psi-mi:Dennd1a(display_short)	psi-mi:sh3g2_mouse(display_long)|uniprotkb:Sh3gl2(gene name)|psi-mi:Sh3gl2(display_short)|uniprotkb:Sh3d2a(gene name synonym)|uniprotkb:Endophilin-1(gene name synonym)|uniprotkb:SH3 domain-containing GRB2-like protein 2(gene name synonym)|uniprotkb:SH3 domain protein 2A(gene name synonym)|uniprotkb:Een1(gene name synonym)|uniprotkb:SH3p4(gene name synonym)	psi-mi:"MI:0096"(pull down)	Allaire et al. (2006)	pubmed:17182770|mint:MINT-7213314|doi:10.1523/JNEUROSCI.4608-06.2006	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7186711|mint:MINT-7213323	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000035392(gene)|ensembl:ENSMUST00000102787(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006897"(endocytosis)|go:"GO:0015031"(protein transport)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030425"(dendrite)|go:"GO:0030665"(clathrin-coated vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032266"(phosphatidylinositol-3-phosphate binding)|go:"GO:0032456"(endocytic recycling)|go:"GO:0032483"(regulation of Rab protein signal transduction)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045202"(synapse)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:1901981"(phosphatidylinositol phosphate binding)|interpro:IPR001194(DENN)|interpro:IPR005112(dDENN)|interpro:IPR005113(uDENN)|interpro:IPR037516|interpro:IPR040032|interpro:IPR043153|mint:Q8K382|reactome:R-MMU-8876198|refseq:NP_666234.3|mint:MINT-7213325(identity)	interpro:IPR035824|interpro:IPR036028|mint:Q62420|rcsb pdb:1ZWW|reactome:R-MMU-177504|reactome:R-MMU-182971|reactome:R-MMU-2132295|reactome:R-MMU-432720|reactome:R-MMU-432722|reactome:R-MMU-437239|reactome:R-MMU-6807004|reactome:R-MMU-8856825|reactome:R-MMU-8856828|go:"GO:0008022"(protein C-terminus binding)|ensembl:ENSMUSG00000028488(gene)|ensembl:ENSMUST00000030212(transcript)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002090"(regulation of receptor internalization)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0008289"(lipid binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016191"(synaptic vesicle uncoating)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031175"(neuron projection development)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045202"(synapse)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0060988"(lipid tube assembly)|go:"GO:0097441"(basal dendrite)|go:"GO:0097484"(dendrite extension)|go:"GO:0097749"(membrane tubulation)|go:"GO:0097753"(membrane bending)|go:"GO:0098684"(photoreceptor ribbon synapse)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099050"(vesicle scission)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:1903527"(positive regulation of membrane tubulation)|go:"GO:1905604"(negative regulation of blood-brain barrier permeability)|go:"GO:1990416"(cellular response to brain-derived neurotrophic factor stimulus)|go:"GO:2000369"(regulation of clathrin-dependent endocytosis)|interpro:IPR001452(Src homology-3)|interpro:IPR004148(BAR)|interpro:IPR027267|refseq:NP_062408.2|dip:DIP-30992N|mint:MINT-7213332(identity)	-	comment:mint|comment:homomint	-	comment:homomint|comment:domino|comment:mint|figure legend:4a|partial coverage:partial coverage|curation depth:mimix curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/06/30	2014/10/16	rogid:SKM0mbBr7ZNoAjf6sNvPlKrNI8w10090	rogid:hAkiLVjGXejkjd5pRcuq9wVXrfk10090	intact-crc:AB33FF837B8FD286|rigid:UUDHaD5uDhmQTqXOulQ72rn+dj0	false	binding-associated region:?-?(MINT-7213327)	binding-associated region:290-349(MINT-7213334)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8K382	uniprotkb:Q9Z0R4	intact:EBI-7186684|ensembl:ENSMUSP00000099848|intact:UNK-5974119|uniprotkb:A0MCI0|uniprotkb:A2ALU2	intact:EBI-645386|uniprotkb:Q9R143|uniprotkb:F8VQE5|ensembl:ENSMUSP00000109635	psi-mi:den1a_mouse(display_long)|uniprotkb:Connecdenn 1(gene name synonym)|uniprotkb:Dennd1a(gene name)|psi-mi:Dennd1a(display_short)	psi-mi:itsn1_mouse(display_long)|uniprotkb:EH and SH3 domains protein 1(gene name synonym)|uniprotkb:Itsn1(gene name)|psi-mi:Itsn1(display_short)|uniprotkb:Ese1(gene name synonym)|uniprotkb:Itsn(gene name synonym)	psi-mi:"MI:0096"(pull down)	Allaire et al. (2006)	pubmed:17182770|mint:MINT-7213314|doi:10.1523/JNEUROSCI.4608-06.2006	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7186752|mint:MINT-7213349	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000035392(gene)|ensembl:ENSMUST00000102787(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006897"(endocytosis)|go:"GO:0015031"(protein transport)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030425"(dendrite)|go:"GO:0030665"(clathrin-coated vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032266"(phosphatidylinositol-3-phosphate binding)|go:"GO:0032456"(endocytic recycling)|go:"GO:0032483"(regulation of Rab protein signal transduction)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045202"(synapse)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:1901981"(phosphatidylinositol phosphate binding)|interpro:IPR001194(DENN)|interpro:IPR005112(dDENN)|interpro:IPR005113(uDENN)|interpro:IPR037516|interpro:IPR040032|interpro:IPR043153|mint:Q8K382|reactome:R-MMU-8876198|refseq:NP_666234.3|mint:MINT-7213356(identity)	refseq:NP_001103745.1|refseq:NP_034717.2|ensembl:ENSMUSG00000022957(gene)|ensembl:ENSMUST00000114002(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006887"(exocytosis)|go:"GO:0006897"(endocytosis)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0015031"(protein transport)|go:"GO:0016197"(endosomal transport)|go:"GO:0019209"(kinase activator activity)|go:"GO:0030027"(lamellipodium)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0034613"(cellular protein localization)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044305"(calyx of Held)|go:"GO:0045202"(synapse)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055037"(recycling endosome)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060124"(positive regulation of growth hormone secretion)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0097440"(apical dendrite)|go:"GO:0097708"(intracellular vesicle)|go:"GO:0098833"(presynaptic endocytic zone)|go:"GO:0098871"(postsynaptic actin cytoskeleton)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0150007"(clathrin-dependent synaptic vesicle endocytosis)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2001288"(positive regulation of caveolin-mediated endocytosis)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000261("EPS15 homology (EH)")|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001452(Src homology-3)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR018247|interpro:IPR035892|interpro:IPR035899|interpro:IPR036028|mint:Q9Z0R4|rcsb pdb:3HS8|rcsb pdb:3JV3|reactome:R-MMU-193648|reactome:R-MMU-3928662|reactome:R-MMU-416482|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-9013148|reactome:R-MMU-9013406|reactome:R-MMU-9013408|mint:MINT-7213351(identity)	-	comment:mint|comment:homomint	-	comment:domino|comment:mint|figure legend:4a|partial coverage:partial coverage|curation depth:mimix curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/06/30	2014/10/16	rogid:SKM0mbBr7ZNoAjf6sNvPlKrNI8w10090	rogid:naFu4D6P1S+/t5+VVVeb0De8lEg10090	intact-crc:9B49F107E18B79D8|rigid:vHMcIDB+Q6MyzKvQgo1bIMCkdYM	false	binding-associated region:?-?(MINT-7213357)	binding-associated region:995-1053(MINT-7213352)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8K382	uniprotkb:Q9Z0R4	intact:EBI-7186684|ensembl:ENSMUSP00000099848|intact:UNK-5974119|uniprotkb:A0MCI0|uniprotkb:A2ALU2	intact:EBI-645386|uniprotkb:Q9R143|uniprotkb:F8VQE5|ensembl:ENSMUSP00000109635	psi-mi:den1a_mouse(display_long)|uniprotkb:Connecdenn 1(gene name synonym)|uniprotkb:Dennd1a(gene name)|psi-mi:Dennd1a(display_short)	psi-mi:itsn1_mouse(display_long)|uniprotkb:EH and SH3 domains protein 1(gene name synonym)|uniprotkb:Itsn1(gene name)|psi-mi:Itsn1(display_short)|uniprotkb:Ese1(gene name synonym)|uniprotkb:Itsn(gene name synonym)	psi-mi:"MI:0096"(pull down)	Allaire et al. (2006)	pubmed:17182770|mint:MINT-7213314|doi:10.1523/JNEUROSCI.4608-06.2006	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7186732|mint:MINT-7213336	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000035392(gene)|ensembl:ENSMUST00000102787(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006897"(endocytosis)|go:"GO:0015031"(protein transport)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030425"(dendrite)|go:"GO:0030665"(clathrin-coated vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032266"(phosphatidylinositol-3-phosphate binding)|go:"GO:0032456"(endocytic recycling)|go:"GO:0032483"(regulation of Rab protein signal transduction)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045202"(synapse)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:1901981"(phosphatidylinositol phosphate binding)|interpro:IPR001194(DENN)|interpro:IPR005112(dDENN)|interpro:IPR005113(uDENN)|interpro:IPR037516|interpro:IPR040032|interpro:IPR043153|mint:Q8K382|reactome:R-MMU-8876198|refseq:NP_666234.3|mint:MINT-7213342(identity)	refseq:NP_001103745.1|refseq:NP_034717.2|ensembl:ENSMUSG00000022957(gene)|ensembl:ENSMUST00000114002(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006887"(exocytosis)|go:"GO:0006897"(endocytosis)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0015031"(protein transport)|go:"GO:0016197"(endosomal transport)|go:"GO:0019209"(kinase activator activity)|go:"GO:0030027"(lamellipodium)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0034613"(cellular protein localization)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044305"(calyx of Held)|go:"GO:0045202"(synapse)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055037"(recycling endosome)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060124"(positive regulation of growth hormone secretion)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0097440"(apical dendrite)|go:"GO:0097708"(intracellular vesicle)|go:"GO:0098833"(presynaptic endocytic zone)|go:"GO:0098871"(postsynaptic actin cytoskeleton)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0150007"(clathrin-dependent synaptic vesicle endocytosis)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2001288"(positive regulation of caveolin-mediated endocytosis)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000261("EPS15 homology (EH)")|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001452(Src homology-3)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR018247|interpro:IPR035892|interpro:IPR035899|interpro:IPR036028|mint:Q9Z0R4|rcsb pdb:3HS8|rcsb pdb:3JV3|reactome:R-MMU-193648|reactome:R-MMU-3928662|reactome:R-MMU-416482|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-9013148|reactome:R-MMU-9013406|reactome:R-MMU-9013408|mint:MINT-7213338(identity)	-	comment:mint|comment:homomint	-	comment:domino|comment:mint|figure legend:4a|partial coverage:partial coverage|curation depth:mimix curation	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2009/06/30	2014/10/16	rogid:SKM0mbBr7ZNoAjf6sNvPlKrNI8w10090	rogid:naFu4D6P1S+/t5+VVVeb0De8lEg10090	intact-crc:0161E2EE55022B61|rigid:vHMcIDB+Q6MyzKvQgo1bIMCkdYM	false	binding-associated region:?-?(MINT-7213343)	binding-associated region:738-799(MINT-7213339)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8K382	uniprotkb:Q62420	intact:EBI-7186684|ensembl:ENSMUSP00000099848|intact:UNK-5974119|uniprotkb:A0MCI0|uniprotkb:A2ALU2	intact:EBI-77971|ensembl:ENSMUSP00000030212|uniprotkb:Q3UTL7|uniprotkb:Q3UY49|uniprotkb:Q8BXS6|uniprotkb:Q8VBV1	psi-mi:den1a_mouse(display_long)|uniprotkb:Connecdenn 1(gene name synonym)|uniprotkb:Dennd1a(gene name)|psi-mi:Dennd1a(display_short)	psi-mi:sh3g2_mouse(display_long)|uniprotkb:Sh3gl2(gene name)|psi-mi:Sh3gl2(display_short)|uniprotkb:Sh3d2a(gene name synonym)|uniprotkb:Endophilin-1(gene name synonym)|uniprotkb:SH3 domain-containing GRB2-like protein 2(gene name synonym)|uniprotkb:SH3 domain protein 2A(gene name synonym)|uniprotkb:Een1(gene name synonym)|uniprotkb:SH3p4(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Allaire et al. (2006)	pubmed:17182770|mint:MINT-7213314|doi:10.1523/JNEUROSCI.4608-06.2006	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7186819|mint:MINT-7213370	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000035392(gene)|ensembl:ENSMUST00000102787(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006897"(endocytosis)|go:"GO:0015031"(protein transport)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030425"(dendrite)|go:"GO:0030665"(clathrin-coated vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032266"(phosphatidylinositol-3-phosphate binding)|go:"GO:0032456"(endocytic recycling)|go:"GO:0032483"(regulation of Rab protein signal transduction)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045202"(synapse)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:1901981"(phosphatidylinositol phosphate binding)|interpro:IPR001194(DENN)|interpro:IPR005112(dDENN)|interpro:IPR005113(uDENN)|interpro:IPR037516|interpro:IPR040032|interpro:IPR043153|mint:Q8K382|reactome:R-MMU-8876198|refseq:NP_666234.3|mint:MINT-7213377(identity)	interpro:IPR035824|interpro:IPR036028|mint:Q62420|rcsb pdb:1ZWW|reactome:R-MMU-177504|reactome:R-MMU-182971|reactome:R-MMU-2132295|reactome:R-MMU-432720|reactome:R-MMU-432722|reactome:R-MMU-437239|reactome:R-MMU-6807004|reactome:R-MMU-8856825|reactome:R-MMU-8856828|go:"GO:0008022"(protein C-terminus binding)|ensembl:ENSMUSG00000028488(gene)|ensembl:ENSMUST00000030212(transcript)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0002090"(regulation of receptor internalization)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0008289"(lipid binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016191"(synaptic vesicle uncoating)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031175"(neuron projection development)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045202"(synapse)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0060988"(lipid tube assembly)|go:"GO:0097441"(basal dendrite)|go:"GO:0097484"(dendrite extension)|go:"GO:0097749"(membrane tubulation)|go:"GO:0097753"(membrane bending)|go:"GO:0098684"(photoreceptor ribbon synapse)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099050"(vesicle scission)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:1903527"(positive regulation of membrane tubulation)|go:"GO:1905604"(negative regulation of blood-brain barrier permeability)|go:"GO:1990416"(cellular response to brain-derived neurotrophic factor stimulus)|go:"GO:2000369"(regulation of clathrin-dependent endocytosis)|interpro:IPR001452(Src homology-3)|interpro:IPR004148(BAR)|interpro:IPR027267|refseq:NP_062408.2|dip:DIP-30992N|mint:MINT-7213372(identity)	-	comment:mint|comment:homomint	-	comment:homomint|comment:domino|comment:mint|figure legend:4c|partial coverage:partial coverage|curation depth:mimix curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2009/06/30	2014/10/16	rogid:SKM0mbBr7ZNoAjf6sNvPlKrNI8w10090	rogid:hAkiLVjGXejkjd5pRcuq9wVXrfk10090	intact-crc:E83F18C139FA462A|rigid:UUDHaD5uDhmQTqXOulQ72rn+dj0	false	binding-associated region:?-?(MINT-7213378)	binding-associated region:290-349(MINT-7213373)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)
uniprotkb:Q8K382	uniprotkb:Q9Z0R4	intact:EBI-7186684|ensembl:ENSMUSP00000099848|intact:UNK-5974119|uniprotkb:A0MCI0|uniprotkb:A2ALU2	intact:EBI-645386|uniprotkb:Q9R143|uniprotkb:F8VQE5|ensembl:ENSMUSP00000109635	psi-mi:den1a_mouse(display_long)|uniprotkb:Connecdenn 1(gene name synonym)|uniprotkb:Dennd1a(gene name)|psi-mi:Dennd1a(display_short)	psi-mi:itsn1_mouse(display_long)|uniprotkb:EH and SH3 domains protein 1(gene name synonym)|uniprotkb:Itsn1(gene name)|psi-mi:Itsn1(display_short)|uniprotkb:Ese1(gene name synonym)|uniprotkb:Itsn(gene name synonym)	psi-mi:"MI:0006"(anti bait coimmunoprecipitation)	Allaire et al. (2006)	pubmed:17182770|mint:MINT-7213314|doi:10.1523/JNEUROSCI.4608-06.2006	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0471"(MINT)	intact:EBI-7186840|mint:MINT-7213382	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000035392(gene)|ensembl:ENSMUST00000102787(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006897"(endocytosis)|go:"GO:0015031"(protein transport)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030425"(dendrite)|go:"GO:0030665"(clathrin-coated vesicle membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032266"(phosphatidylinositol-3-phosphate binding)|go:"GO:0032456"(endocytic recycling)|go:"GO:0032483"(regulation of Rab protein signal transduction)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045202"(synapse)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:1901981"(phosphatidylinositol phosphate binding)|interpro:IPR001194(DENN)|interpro:IPR005112(dDENN)|interpro:IPR005113(uDENN)|interpro:IPR037516|interpro:IPR040032|interpro:IPR043153|mint:Q8K382|reactome:R-MMU-8876198|refseq:NP_666234.3|mint:MINT-7213389(identity)	refseq:NP_001103745.1|refseq:NP_034717.2|ensembl:ENSMUSG00000022957(gene)|ensembl:ENSMUST00000114002(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006887"(exocytosis)|go:"GO:0006897"(endocytosis)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0015031"(protein transport)|go:"GO:0016197"(endosomal transport)|go:"GO:0019209"(kinase activator activity)|go:"GO:0030027"(lamellipodium)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0034613"(cellular protein localization)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044305"(calyx of Held)|go:"GO:0045202"(synapse)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0055037"(recycling endosome)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060124"(positive regulation of growth hormone secretion)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0097440"(apical dendrite)|go:"GO:0097708"(intracellular vesicle)|go:"GO:0098833"(presynaptic endocytic zone)|go:"GO:0098871"(postsynaptic actin cytoskeleton)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0150007"(clathrin-dependent synaptic vesicle endocytosis)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:2001288"(positive regulation of caveolin-mediated endocytosis)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000261("EPS15 homology (EH)")|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001452(Src homology-3)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR018247|interpro:IPR035892|interpro:IPR035899|interpro:IPR036028|mint:Q9Z0R4|rcsb pdb:3HS8|rcsb pdb:3JV3|reactome:R-MMU-193648|reactome:R-MMU-3928662|reactome:R-MMU-416482|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-9013148|reactome:R-MMU-9013406|reactome:R-MMU-9013408|mint:MINT-7213384(identity)	-	comment:mint|comment:homomint	-	comment:domino|comment:mint|figure legend:4b|partial coverage:partial coverage|curation depth:mimix curation	taxid:9606(human)|taxid:9606(Homo sapiens)	-	2009/06/30	2014/10/16	rogid:SKM0mbBr7ZNoAjf6sNvPlKrNI8w10090	rogid:naFu4D6P1S+/t5+VVVeb0De8lEg10090	intact-crc:7F0594472CD5F13E|rigid:vHMcIDB+Q6MyzKvQgo1bIMCkdYM	false	binding-associated region:?-?(MINT-7213390)	binding-associated region:738-799(MINT-7213385)	-	-	psi-mi:"MI:0396"(predetermined participant)	psi-mi:"MI:0396"(predetermined participant)